title: Establishment of the germ cell lineage in mammals.
abstract: The germ cell lineage in mice becomes lineage-restricted about 7.2 days postcoitum. Its progenitors have migrated from the proximal region of the epiblast. Cells from the distal region of the epiblast will also give rise to germ cells, if they are transplanted to the proximal region at the appropriate time. Cells in this region are subject to a predisposing signal from the adjacent extra-embryonic ectoderm. It appears that this and other signals determine the emergence of germ cells: unlike in some other organisms, this event is not predetermined.
authors.affiliation: Wellcome/Cancer Research Campaign Institute, Cambridge, United Kingdom. a.mclarenwelc.cam.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: McLaren
mesh_terms: D000818:Animals; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D002460:Cell Line; D002468:Cell Physiological Phenomena; D003584:Cytological Techniques; D005854:Germ Cells / Q000166:cytology* / Q000502:physiology; D049673:History, 20th Century; D008322:Mammals / Q000502:physiology; D010827:Physiology / Q000266:history
chemical_list: C525810:Bmp4 protein, mouse; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins