title: Longterm treatment of psoriasis using fumaric acid preparations can be associated with severe proximal tubular damage.
abstract: Fumaric acid preparations are used as longterm and effective treatment of psoriasis. Apart from gastrointestinal, dermatological and hematological side-effects, transient renal damage was observed during treatment with fumaric acid. The case of a 38 year old woman who was treated with fumaric acid (420 mg bid) for 5 years before she complained of fatigue and weakness. According to clinical laboratory she had developed severe proximal tubular damage. Hypophosphatemia, glycosuria and proteinuria persisted although medication was stopped immediately.
authors.affiliation: General Hospital Fulda, Medical Department, Pacelliallee 4, 36043 Fulda, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Raschka
authors.forename: H J
authors.initials: HJ
authors.lastname: Koch
mesh_terms: D000328:Adult; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis*; D005260:Female; D005650:Fumarates / Q000009:adverse effects* / Q000627:therapeutic use; D006029:Glycosuria / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D017674:Hypophosphatemia / Q000139:chemically induced / Q000175:diagnosis; D011507:Proteinuria / Q000139:chemically induced / Q000175:diagnosis; D011565:Psoriasis / Q000188:drug therapy*; D013995:Time
chemical_list: D005650:Fumarates; C032005:fumaric acid