title: [Proton-activated K+-channels of frog taste receptor cells].
abstract: It is conventionally accepted that sour transduction does not require a receptor mechanism and is based on a direct interaction of acid stimuli with apical ion channels. At the same time, it has been shown that a number of neuronal cells express H(+)-gated cation channels. We studied the effect of acid stimuli on ion currents recorded from frog Rana temporaria taste receptor cells and found that a substantial subpopulation of them exhibited K+ currents activated by extracellular protons. To our knowledge, this is the first demonstration of H(+)-gated K+ channels in cells of any type including taste receptor cells. These channels are presumably involved in sour transduction and/or contribute to intercellular communications between discoid cells.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Bobkov
authors.forename: A A
authors.initials: AA
authors.lastname: Grishin
authors.forename: O A
authors.initials: OA
authors.lastname: Rogachevskaia
authors.forename: S S
authors.initials: SS
authors.lastname: Kolesnikov
mesh_terms: D000818:Animals; D002450:Cell Communication; D015640:Ion Channel Gating; D017136:Ion Transport; D010812:Physical Stimulation; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000378:metabolism*; D011522:Protons; D011896:Rana temporaria; D015398:Signal Transduction; D013650:Taste Buds / Q000378:metabolism*
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels; D011522:Protons