Cytogenetic abnormalities in multiple myeloma.
There is an increasing understanding that chromosomal abnormalities play a major role in the pathogenesis of multiple myeloma. Furthermore, they seem to predict the clinical outcome of patients according to the specific abnormalities detected. It is likely that in the future, knowledge of the cytogenetic composition will be an integral part of the evaluation of myeloma patients.
Fonseca
R
R
Department of Hematology, Mayo Clinic, Rochester, Minnesota, USA. fonseca.rafael@mayo.edu
Coignet
L J
LJ
Dewald
G W
GW
D002869:Chromosome Aberrations; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009101:Multiple Myeloma / Q000235:genetics*; D011379:Prognosis