The factor V Leiden mutation is not a common cause of pregnancy-induced hypertension in Japan.
Recent studies in Caucasian populations have shown an association of the Leiden mutation in factor V with preeclampsia (PE). It consists of a substitution of a G (G1691) with an A (A1691) at nucleotide position 1691 in exon 10, resulting in arginine instead of glutamine at residue 506 at the factor V cleavage site for activated protein C (APC); it contributes to the resistance to APC. The purpose of this study was to determine whether the Leiden mutation is associated with pregnancy-induced hypertension (PIH), including PE, in Japanese women. We examined the genotypes of factor V of 71 Japanese patients with PIH and 109 controls. None of the 180 Japanese women carried the factor V Leiden mutation. To date, the factor V Leiden mutation is rare and not a common cause of PIH in Japan. The results may suggest that there is a significant ethnic difference in the role of the Leiden mutation in compounding the risk factors in the pathogenesis of PIH between Japanese and Caucasian populations.
Kobashi
G
G
Department of Public Health, Hokkaido University School of Medicine, Sapporo, Japan.
Yamada
H
H
Asano
T
T
Nagano
S
S
Hata
A
A
Kishi
R
R
Kondo
K
K
Fujimoto
S
S
D020016:Activated Protein C Resistance; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005192:Family Health; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D017354:Point Mutation; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics*; D011247:Pregnancy; D012189:Retrospective Studies
C095381:factor V Leiden; D005165:Factor V