title: The preparation of amino-substituted biaryl libraries: the application of solid-supported reagents to streamline solution-phase synthesis.
abstract: A small library of isomeric benzylamino biaryls was generated in a semi-automated fashion using a solution-phase strategy employing a solid-supported, readily filterable base to facilitate electrophilic substitution followed in sequence by a metal-catalyzed cross-coupling reaction.
authors.affiliation: Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario, Canada, M3J 1P3.
authors.forename: M G
authors.initials: MG
authors.lastname: Organ
authors.forename: C E
authors.initials: CE
authors.lastname: Dixon
mesh_terms: D001331:Automation / Q000379:methods; D001596:Benzylamines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D019992:Databases as Topic; D015195:Drug Design; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008670:Metals; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D001596:Benzylamines; D006841:Hydrocarbons, Aromatic; D007202:Indicators and Reagents; D008670:Metals