Molecular recognition events involved in the activation of the growth hormone receptor by growth hormone.
Binding of growth hormone (GH) to its receptor (GHR) is a well-studied example of molecular recognition between a cytokine and its receptor. Extensive mutagenesis studies and several crystal structures have defined the key interactive amino acid residues that are involved in binding and subsequent receptor dimerization. This review encompasses each of the three molecular recognition events involved in GHR activation, namely binding of GH to its two receptors and the interactions that occur between these receptors. Particular attention is given to species and ligand specificity of hormone binding and to the molecular recognition events involved in receptor activation, including the possibility that a conformational change in the receptor is required.
Behncken
S N
SN
Department of Physiology and Pharmacology and Centre for Molecular and Cellular Biology, University of Queensland, St Lucia 4072, Australia.
Waters
M J
MJ
D000818:Animals; D001665:Binding Sites; D019281:Dimerization; D004921:Erythropoietin / Q000378:metabolism / Q000494:pharmacology; D013006:Growth Hormone / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D019382:Human Growth Hormone / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D011323:Primates / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017467:Receptors, Erythropoietin / Q000737:chemistry / Q000378:metabolism; D011981:Receptors, Prolactin / Q000378:metabolism; D011986:Receptors, Somatotropin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D015032:Zinc / Q000378:metabolism
D008024:Ligands; D017467:Receptors, Erythropoietin; D011981:Receptors, Prolactin; D011986:Receptors, Somatotropin; D004921:Erythropoietin; D019382:Human Growth Hormone; D011388:Prolactin; D013006:Growth Hormone; D015032:Zinc