Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract: part V.
Effect of Azadirachta indica leaf extract on serotonin inhibition in glucose mediated insulin release in rat pancreas was studied in vitro to elucidate the possible mechanism of antihyperglycemic effect of A. indica leaf extract. A. indica leaf extract blocks significantly (P < 0.05) the inhibitory effect of serotonin on insulin secretion mediated by glucose.
Chattopadhyay
R R
RR
Biometry Research Unit, Indian Statistical Institute, Calcutta.
D000818:Animals; D005947:Glucose / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology
D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D012702:Serotonin Antagonists; D005947:Glucose