Minimally differentiated acute myeloid leukemia (AML-M0) with extensive erythrophagocytosis and del(20)(q11) chromosome abnormality.
We describe an 84-year-old woman who presented severe pancytopenia and 36.6% of blasts accompanied with erythrophagocytosis in the bone marrow. According to cytochemical and immunological findings, a diagnosis of minimally differentiated acute myeloid leukemia (AML-M0) was established. Cytogenetic analysis revealed del(20)(q11) which were previously reported for one case each of ALL and MDS associated with cytophagocytosis by blasts, leading us to speculate a disease entity. Interestingly, a high expression of mRNA of TNF-alpha was detected by RT-PCR on the bone marrow mononuclear cells.
Mori
H
H
Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Japan.
Tawara
M
M
Yoshida
Y
Y
Kuriyama
K
K
Sugahara
K
K
Kamihira
S
S
Tomonaga
M
M
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics* / Q000648:ultrastructure; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D004912:Erythrocytes; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D010587:Phagocytosis / Q000235:genetics; D010641:Phenotype
D016207:Cytokines; D009363:Neoplasm Proteins