[Resistance of Mycobacterium tuberculosis in Ferrol, Spain. Associated factors].
OBJECTIVE
To know the frequency of resistances of Mycobacterium tuberculosis and the associated factors.


METHODS
Prospective study of the sensitivity of Mycobacterium tuberculosis by means of the method of the proportions of Canetti in the Hospital Arquitecto Marcide-Profesor Novoa Santos (Ferrol, Spain) among 1991 and 1998. A descriptive and multiple regression analyses were performed.


RESULTS
Were studied 355 strains. Primary resistance: Isoniazid 1.1%, Streptomycin 1.1%. Secondary resistance: Isoniazid 11.6%, in the 5.2% existed multidrug-resistance. The risk factors for drug-resistant tuberculosis were previous treatment (odds ratio [OR] = 10.9; 95% CI, 2.9-39.4) and age higher than 40 years (OR = 3.9; 95% CI, 1.1-14.5).


CONCLUSIONS
A low frequency of resistance was observed. The factors associated with the resistances were previous treatment and age.
García Rodríguez
J F
JF
Servicio de Medicina Interna, Universidad de Santiago de Compostela.
Mariño Callejo
A
A
Lorenzo García
M V
MV
Rodríguez Mayo
M
M
Domínguez Gómez
D
D
Sesma Sánchez
P
P
D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000150:complications*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology*
D000995:Antitubercular Agents