title: Evaluation of the optimal driving mode during left ventricular assist with pulsatile catheter pump in calves.
abstract: The pulsatile catheter (PUCA) pump, a left ventricular assist device, was tested during acute experiments in calves using asynchronous and ECG-synchronous assist modes. The aim of the study is to compare ECG-synchronous and asynchronous assist and to find the optimal driving mode for the PUCA pump with respect to left ventricular myocardial oxygen consumption (LV MVO2), pump flow, and coronary flow. LV MVO2 decreased significantly during the asynchronous (from 7.77 to 6.46 ml/min/100 g) as well as during the ECG-synchronous mode (from 8.88 to 7.84 ml/min/100 g). The pump flow was highest during the ECG-synchronous assist (2.94 L/min), followed by the asynchronous assist (2.79 L/min). The peak coronary flow depended strongly on pump ejection timing and showed the best flow patterns during the ECG-synchronous assist. We concluded that for PUCA pump support both asynchronous and ECG-synchronous assists significantly reduce LV MVO2 and that the pump flow generated is enough to maintain the systemic circulation. However, we find the ECG-synchronous mode preferable because this mode optimizes coronary flow patterns at the same time.
authors.affiliation: Division of Artificial Organs, Institute for BMSA, University of Groningen, The Netherlands.
authors.forename: D
authors.initials: D
authors.lastname: Mihaylov
authors.forename: G J
authors.initials: GJ
authors.lastname: Verkerke
authors.forename: P K
authors.initials: PK
authors.lastname: Blanksma
authors.forename: J
authors.initials: J
authors.lastname: Elstrodt
authors.forename: E D
authors.initials: ED
authors.lastname: De Jong
authors.forename: G
authors.initials: G
authors.lastname: Rakhorst
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006328:Cardiac Catheterization / Q000295:instrumentation; D002302:Cardiac Output / Q000502:physiology; D002417:Cattle; D003326:Coronary Circulation / Q000502:physiology; D004569:Electroencephalography; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D006339:Heart Rate / Q000502:physiology; D006352:Heart Ventricles / Q000378:metabolism; D006353:Heart-Assist Devices; D006801:Humans; D008567:Membranes, Artificial; D010101:Oxygen Consumption / Q000502:physiology; D011673:Pulsatile Flow; D016277:Ventricular Function, Left
chemical_list: D008567:Membranes, Artificial