[The comparative activity of cefepime and other current antibiotics against microorganisms isolated from patients in pediatric intensive therapy units].
Comparative activity of cefepime, ceftazidime, ceftriaxone, ciprofloxacin, imipenem and piperacillin/tazobactam against isolates from patients of pediatric intensive care units within October-December 1998 was studied. The isolates were identified with the Walkaway-40 System. The antibiotic susceptibility was evaluated by the E-test on the Mueller-Hinton II agar. The data were interpreted in accordance with the NCCLS. The number of the isolates totaled 100. Among them not more than 10 to 12 strains belonged to the same species. 92 per cent of the isolates was susceptible to cefepime and 70 to 75 per cent of the isolates were susceptible to the third generation cephalosporins. Piperacillin/tazobactam proved to be highly susceptible, the number of the isolates resistant and moderately resistant to it being 6 and 1 per cent respectively. The results showed that cefepime was intermediate between the third generation cephalosporins and carbapenems.
Kurchavov
V A
VA
Laboratory of Microbiology, N. F. Filatov Municipal Pediatric Clinical Hospital No. 13, Moscow.
Beloborodova
N V
NV
Biriukov
A V
AV
Vostrikova
T Iu
TIu
Rogatina
E L
EL
Krutskikh
E N
EN
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D002648:Child; D003428:Cross Infection / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008826:Microbial Sensitivity Tests / Q000295:instrumentation / Q000706:statistics & numerical data
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D000077723:Cefepime