The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.
Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.
Cane
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Department of Chemistry, Brown University, Providence, RI 02912-9108, USA. David_Cane@brown.edu
Walsh
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D020134:Catalytic Domain; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D010442:Peptide Chain Initiation, Translational; D010443:Peptide Chain Termination, Translational; D010453:Peptide Synthases / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D012270:Ribosomes
D009097:Multienzyme Complexes; D010453:Peptide Synthases