title: [Topological similarity of antagonist binding sites in biogenic amine receptors].
abstract: The influence of physical and chemical properties of some sites of transmembrane receptor domains on the receptors ability to interact with nonspecific antagonists was investigated mathematically. The properties of sites located in 3rd and 7th transmembrane domains are most likely to explain pharmacological characteristics of the receptors. The possibility of receptor blocking by nonspecific antagonists not by competing with agonists but by influencing the receptor conformation is discussed.
authors.affiliation: Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences, Kyiv, Ukraine.
authors.forename: G N
authors.initials: GN
authors.lastname: Batrak
authors.forename: S E
authors.initials: SE
authors.lastname: Mogilevich
authors.forename: A I
authors.initials: AI
authors.lastname: Luĭk
authors.forename: V V
authors.initials: VV
authors.lastname: Prokopenko
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D051381:Rats; D017982:Receptors, Biogenic Amine / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D017982:Receptors, Biogenic Amine