title: A mammalian H+ channel generated through alternative splicing of the NADPH oxidase homolog NOH-1.
abstract: Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).
authors.affiliation: Biology of Aging Laboratory, Department of Geriatrics, Geneva University Hospitals, Geneva Medical School, CH-1211 Geneva 4, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Bánfi
authors.forename: A
authors.initials: A
authors.lastname: Maturana
authors.forename: S
authors.initials: S
authors.lastname: Jaconi
authors.forename: S
authors.initials: S
authors.lastname: Arnaudeau
authors.forename: T
authors.initials: T
authors.lastname: Laforge
authors.forename: B
authors.initials: B
authors.lastname: Sinha
authors.forename: E
authors.initials: E
authors.lastname: Ligeti
authors.forename: N
authors.initials: N
authors.lastname: Demaurex
authors.forename: K H
authors.initials: KH
authors.lastname: Krause
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D002460:Cell Line; D003600:Cytosol / Q000378:metabolism; D004553:Electric Conductivity; D004579:Electron Transport; D020224:Expressed Sequence Tags; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D000074624:NADPH Oxidase 1; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000737:chemistry / Q000235:genetics*; D018408:Patch-Clamp Techniques; D011522:Protons; D014162:Transfection; D014407:Tumor Cells, Cultured; D015032:Zinc / Q000494:pharmacology
chemical_list: D007473:Ion Channels; D008562:Membrane Glycoproteins; D011522:Protons; D006859:Hydrogen; C056558:CYBB protein, human; D000074624:NADPH Oxidase 1; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; C402799:NOX1 protein, human; D015032:Zinc