Phytate (IP6) is a powerful agent for preventing calcifications in biological fluids: usefulness in renal lithiasis treatment.
The extraordinary capacity of phytate (myo-inositol hexaphosphate), a substance present in blood, urine, interstitial and intracellular fluids, to inhibit crystallization of calcium salts (oxalate and phosphate) is discussed. Its role in preventing calcium renal stone formation is specifically presented and discussed. "In vitro" and "in vivo" experiments, as well as clinical studies clearly demonstrated that phytate plays an important role as a crystallization inhibitor of calcium salts in biological fluids and becomes a clear alternative in the treatment of calcium oxalate renal lithiasis.
Grases
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Laboratory of Investigation into Renal Lithiasis, Faculty of Sciences, University of Illes Balears, Palma de Mallorca, Spain.
Costa-Bauzá
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D000818:Animals; D002114:Calcinosis / Q000517:prevention & control*; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy*; D010833:Phytic Acid / Q000494:pharmacology* / Q000627:therapeutic use
D010833:Phytic Acid