Activation of moesin and adducin by Rho-kinase downstream of Rho.
The Rho GTPase (Rho) is a member of the Rho family, which belongs to the Ras superfamily of GTP-binding proteins. Like other GTP-binding proteins, Rho exists in two conformational states, an inactive GDP-bound form and an active GTP-bound form. Active Rho interacts with specific effectors to regulate the actin cytoskeleton and to mediate a variety of biological functions in cells. Rho-associated kinase (Rho-kinase) is the most studied Rho-effector, and studies of its biochemical and cell biological functions have provided us with useful information for understanding the molecular mechanisms of the actions of Rho. This review aims to summarize the roles of Rho and Rho-kinase in the regulation of the cytoskeletons.
Fukata
Y
Y
Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan.
Oshiro
N
N
Kaibuchi
K
K
D002148:Calmodulin-Binding Proteins / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D054460:rho-Associated Kinases; D000099291:Adducins
D002148:Calmodulin-Binding Proteins; D019204:GTP-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008840:Microfilament Proteins; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases; D000099291:Adducins; C071058:moesin