Leishmania donovani invasion of the blood in a child with dermal leishmaniasis.
Cutaneous leishmaniasis is highly endemic in eastern Mediterranean countries. The causative organisms are Leishmania tropica or Leishmania major but, further west, variants of Leishmania infantum frequently cause cutaneous leishmaniasis. We report a young girl from Beirut with an acute cutaneous leishmaniasis in whom the causative organism was cultured from both the skin lesion and the blood in the absence of any signs or symptoms typical of systemic involvement. The parasite was found to have a zymodeme typical of organisms belonging to the L. donovani complex. With the negative past history and in the absence of anti-Leishmania antibodies in her serum, post-kala-azar dermal leishmaniasis is an unlikely possibility, especially in view of the rarity of the complication in this part of the world. The infection was probably acquired during a recent visit to Aleppo, where cutaneous leishmaniasis is hyperendemic as similar cases have not been reported in Beirut. This case indicates the need to consider L. infantum strains in addition to L. tropica in cutaneous disease in Aleppo. This case also demonstrates that L. infantum can spread by the haematogenous route, even in a child without evidence of the immunosuppression, which usually predisposes to such spread.
Nuwayri-Salti
N
N
Department of Human Morphology, Faculty of Medicine, American University of Beirut, Lebanon. racha@layla.aub.edu.lb
Salman
S
S
Shahin
N M
NM
Malak
J
J
D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D018314:Leishmania infantum / Q000302:isolation & purification*; D016773:Leishmaniasis, Cutaneous / Q000469:parasitology*; D018512:Parasitemia / Q000469:parasitology*; D012867:Skin / Q000469:parasitology