title: Necrobiosis lipoidica: a case with prominent cholesterol clefting and transepithelial elimination.
abstract: Transepithelial elimination of degenerated collagen through the hair follicle in necrobiosis lipoidica is rare, clinically manifesting as comedo-like plugs. Also unusual in necrobiosis lipoidica is the finding of cholesterol cleft formation. We report a case of necrobiosis lipoidica with transepithelial elimination of cholesterol crystals through hair follicles. This has been described in necrobiotic xanthogranuloma, demonstrating some overlap in the histopathologic findings in both necrobiotic granulomas. Additional criteria should be used to establish the diagnosis.
authors.affiliation: Service of Dermatology, Hospital Provincial, Pontevedra, Spain.
authors.forename: C
authors.initials: C
authors.lastname: De la Torre
authors.forename: A
authors.initials: A
authors.lastname: Losada
authors.forename: M J
authors.initials: MJ
authors.lastname: Cruces
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D009335:Necrobiosis Lipoidica / Q000378:metabolism / Q000473:pathology*; D012867:Skin / Q000378:metabolism / Q000473:pathology*
chemical_list: D002784:Cholesterol