title: [Neonatal staphylococcal epidermolysis due to maternal-fetal transmission].
abstract: BACKGROUND
  The staphylococcal scalded skin syndrome (SSSS) is due to exfoliative toxins A or B excreted by some strains of Staphylococcus aureus. This syndrome is exceptional in the first hours of life. We report a case of SSSS due to materno-fetal infection.
  
  
  METHODS
  At 31 weeks of pregnancy a 40-year-old mother was febrile (39 degrees C) and a premature rupture of the amniotic sac occurred the following day. SSSS was diagnosed at 6 hours of life in the newborn, a 1760 g female. Staphylococcus aureus grew on the blood and vaginal bacterial cultures of the mother, as well as, from cultures of skin, nose, throat, and umbilical catheter in the newborn. The strains of Staphylococcus aureus isolated in the mother and the child had identical characteristic antibiotype and genotype by Random-PCR. The genes for both exfoliations A and B were present. Epidermization was rapidly obtained and no septicemia or septic complication was noted.
  
  
  CONCLUSIONS
  Staphylococcus aureus is usually responsible for nosocomial infections which occur in the early newborn period. In most cases, the infection is transmitted by a carrier who manipulates the child (family, visitors, nurse or medical staff). In our case, onset of SSSS early after birth suggested a perinatal transmission, due to lower genital tract infection in the mother. The presence of SSSS in the child and not in the mother may be explained by a massive perinatal infection and low elimination of the toxin in the newborn resulting in higher concentrations of exfoliative toxins in the blood.
authors.affiliation: Unité de Dermatologie Pédiatrique, Hôpital Pellegrin-Enfants, Bordeaux.
authors.forename: C
authors.initials: C
authors.lastname: Léauté-Labrèze
authors.forename: J
authors.initials: J
authors.lastname: Sarlangue
authors.forename: L
authors.initials: L
authors.lastname: Pedespan
authors.forename: H P
authors.initials: HP
authors.lastname: Doermann
authors.forename: A
authors.initials: A
authors.lastname: Taïeb
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000382:microbiology; D002406:Catheterization, Peripheral; D005083:Exfoliatins / Q000032:analysis / Q000235:genetics; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009666:Nose / Q000382:microbiology; D010614:Pharynx / Q000382:microbiology; D011247:Pregnancy; D012703:Serotyping; D013206:Staphylococcal Scalded Skin Syndrome / Q000635:transmission*; D013211:Staphylococcus aureus / Q000145:classification / Q000235:genetics; D014470:Umbilical Cord; D014621:Vagina / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D005083:Exfoliatins