title: Latanoprost 0.005% and anterior segment uveitis.
abstract: OBJECTIVE
  To evaluate the association of latanoprost with anterior chamber uveitis in glaucoma patients.
  
  
  METHODS
  We retrospectively reviewed 527 charts in latanoprost treated patients with: no prior uveitis (Group 1); prior uveitis but were inactive at the time of the study (Group 2); and active uveitis (Group 3).
  
  
  RESULTS
  In Group 1 five (1.0%) of 505 patients developed uveitis after beginning latanoprost. The uveitis was trace to 1+ cell in severity and delayed in onset 99.8+/-73.9 days In Group 2 three of 13 (23.1%) patients developed delayed uveitis (trace to 1+ cell). In Group 3 zero of nine (0%) patients had worsened inflammation and the intraocular pressure remained unchanged (22.8+/-7.8 mmHg to 22.0+/-7.3 mmHg) after beginning latanoprost (p=0.38).
  
  
  CONCLUSIONS
  In patients without a prior history a mild delayed uveitis with latanoprost treatment may develop rarely. In patients with a uveitis history, a mild delayed exacerbation potentially may occur and the intraocular pressure may not be decreased in active uveitis.
authors.affiliation: Lehmann Eye Center, Nacogdoches, Texas, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Smith
authors.forename: C A
authors.initials: CA
authors.lastname: Pruitt
authors.forename: C S
authors.initials: CS
authors.lastname: Sine
authors.forename: A C
authors.initials: AC
authors.lastname: Hudgins
authors.forename: W C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D015994:Incidence; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D009798:Ocular Hypertension / Q000188:drug therapy; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D013781:Texas / Q000453:epidemiology; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology
chemical_list: D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost