Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms.
OBJECTIVE
In order to easily assess individual differences in response to alcohol, the Self-Rating of the Effects of Alcohol (SRE) form was recently developed and its psychometric properties tested in primarily white subjects. This study aimed to further evaluate the SRE in a population known to have genetically mediated variability in response to alcohol and risk for alcoholism, Asian Americans with ALDH2 polymorphisms.


METHODS
Men and women of Chinese, Japanese or Korean heritage between the ages of 21 and 26 years (N = 156) completed the SRE and a blood sample was drawn for genotyping at the ALDH2 locus.


RESULTS
SRE results were available from 137 (78 female) subjects. With the effects of gender, body weight, frequency of recent drinking and quantity of recent drinking controlled, ALDH2 genotype still accounted for a significant amount of variability in SRE score in this Asian-American sample. Evaluation of SRE scores 4.5 or higher indicated that a low response to alcohol was associated with ALDH2*1/2*1 genotype, male gender and Korean heritage, all factors associated with increased risk for alcoholism.


CONCLUSIONS
These results provide additional support for the SRE as a valid instrument for assessing individual variability in response to alcohol and as a useful measure for identifying individuals at relatively increased or decreased risk for alcoholism based on level of reaction to alcohol.
Wall
T L
TL
Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, 92161, USA.
Johnson
M L
ML
Horn
S M
SM
Carr
L G
LG
Smith
T L
TL
Schuckit
M A
MA
D000328:Adult; D000428:Alcohol Drinking / Q000208:ethnology / Q000235:genetics* / Q000523:psychology; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D001213:Asian / Q000235:genetics* / Q000523:psychology; D001835:Body Weight; D002681:China / Q000208:ethnology; D005260:Female; D005838:Genotype; D006801:Humans; D007564:Japan / Q000208:ethnology; D007723:Korea / Q000208:ethnology; D008297:Male; D015999:Multivariate Analysis; D011594:Psychometrics; D015203:Reproducibility of Results; D012737:Sex Factors
C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial