Influence of foscarnet on HIV-associated Kaposi's sarcoma derived cell lines.
Recent reports showed a positive therapeutic effect of foscarnet on Kaposi's sarcoma (KS) in HIV-positive patients. We investigated the therapeutic effect of foscarnet on KS-derived cell lines. Three KS spindle cell cultures of HIV-positive patients as well three fibroblast cell cultures of HIV-positive as HIV-negative patients were established. The influence of different foscarnet concentrations (50, 100, 200, 400, 600, 1000 microg/ml) on these cell lines were analysed. There was no significant change in fibroblast cell numbers suggesting that there is neither a proliferative nor an antiproliferative effect of foscarnet on these cell lines. Furthermore, incubation of the three KS-derived cell lines of HIV-positive patients with different foscarnet concentrations did not change KS-cell number significantly.
Willers
C P
CP
Ruhr-University Bochum, St. Josef-Hospital, Gudrunstr. 56, D-44791 Bochum, Germany.
Reimann
G
G
Mertins
L
L
Brockmeyer
N H
NH
D000998:Antiviral Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D017245:Foscarnet / Q000494:pharmacology*; D015658:HIV Infections / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
D000998:Antiviral Agents; D017245:Foscarnet