A portrait of the Bcl-2 protein family: life, death, and the whole picture.
The Bcl-2 family of proteins are important regulators of cell death. They are comprised of two opposing factions, the proapoptotic versus the antiapoptotic members. Both are required for normal development and cellular homeostasis of the immune system and other tissues. However, in certain circumstances they may participate in the development of disease.
Pellegrini
M
M
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Strasser
A
A
D000818:Animals; D017209:Apoptosis; D015551:Autoimmunity; D006801:Humans; D007239:Infections / Q000473:pathology; D009369:Neoplasms / Q000473:pathology; D019636:Neurodegenerative Diseases / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*
D019253:Proto-Oncogene Proteins c-bcl-2