Organ preservation for the treatment of contralateral testicular seminoma.
OBJECTIVE
Local excision of germ cell tumor in the remaining testicle followed by a modest dose of irradiation is an alternative to orchiectomy. This organ sparing technique provides superior quality of life and reduces the need for lifelong hormone replacement.


METHODS
We treated two patients with contralateral seminomas with organ preservation. Both patients received postoperative irradiation to the remaining testicle to a dose of 20 Gy in 10 fractions and 19.8 Gy in 11 fractions.


RESULTS
Both patients are alive with no evidence of disease more than 3 years since the completion of their treatments. They both have reduced but preserved androgen production and retained their virility. They both are azospermic.


CONCLUSIONS
We conclude that organ preservation for the treatment of contralateral testicular seminoma is a superior alternative to orchiectomy of the remaining testicle. It preserves male hormone production with equal survival outcome expectations.
Kazem
I
I
Department of Radiation Oncology, Penn State Geisinger Medical Center, Danville 17822, USA.
Danella
J F
JF
D000328:Adult; D006801:Humans; D008297:Male; D009919:Orchiectomy; D018239:Seminoma / Q000532:radiotherapy* / Q000601:surgery; D013736:Testicular Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D013737:Testis / Q000528:radiation effects