Sequence evidence for an altered genetic code in the Neospora caninum plastid.
The plastid DNA of Neospora caninum encodes a homologue of the rpoB gene, which is believed to encode a subunit of a bacterial or chloroplast-like RNA polymerase. The predicted protein product of the N. caninum rpoB gene has three in-frame UGA codons which appear to encode tryptophan residues rather than act as stop codons. Based on the nucleotide sequence of a portion of the ssrRNA gene of the N. caninum plastid, a model for suppression of UGA termination in this plastid is presented.
Lang-Unnasch
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Department of Medicine, University of Alabama at Birmingham, 35294-2170, USA. nlang-unnasch@geomed.dom.uab.edu
Aiello
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D000595:Amino Acid Sequence; D000818:Animals; D003062:Codon; D016054:DNA, Protozoan / Q000235:genetics*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000235:genetics*; D017125:Genes, Protozoan; D020459:Genes, rRNA / Q000235:genetics*; D008969:Molecular Sequence Data; D018688:Neospora / Q000201:enzymology / Q000235:genetics*; D009690:Nucleic Acid Conformation; D010963:Plasmodium falciparum / Q000235:genetics; D018087:Plastids / Q000235:genetics*; D017422:Sequence Analysis, DNA
D003062:Codon; D016054:DNA, Protozoan; D012321:DNA-Directed RNA Polymerases; C105078:RNA polymerase beta subunit