Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.
Biggadike
K
K
Medicinal Chemistry, Enzyme Pharmacology, Biomet Doscovery and Potein Science Units, Glaxo Wellcome Research and Development, Medicines Research Centre, Hertsfordshire, UK. kb0903@ggr.co.uk
Angell
R M
RM
Burgess
C M
CM
Farrell
R M
RM
Hancock
A P
AP
Harker
A J
AJ
Irving
W R
WR
Ioannou
C
C
Procopiou
P A
PA
Shaw
R E
RE
Solanke
Y E
YE
Singh
O M
OM
Snowden
M A
MA
Stubbs
R J
RJ
Walton
S
S
Weston
H E
HE
D043303:Aryldialkylphosphatase; D002254:Carbonates / Q000097:blood / Q000737:chemistry*; D004950:Esterases / Q000097:blood*; D005938:Glucocorticoids / Q000097:blood / Q000737:chemistry*; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D007783:Lactones / Q000097:blood / Q000737:chemistry*; D008168:Lung / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013347:Subcellular Fractions / Q000378:metabolism
D002254:Carbonates; D005938:Glucocorticoids; D007783:Lactones; D011355:Prodrugs; D004950:Esterases; D043303:Aryldialkylphosphatase