title: Possible role of Schistosoma mansoni infection in male hypogonadism.
abstract: Schistosomiasis has been suggested to decrease the reproductive potential or castrate both invertebrate and vertebrate hosts. Furthermore, schistosomiasis may cause anatomic anomalies of the reproductive organs responsible for permanent or reversible infertility. To specify the effect of schistosomiasis on gonadal functions, production of testosterone (TS), leutinizing hormone (LH) and estradiol (E2) in Egyptian men infected with schistosomiasis were studied. All participants were tested for the following parameters: Clinical examination and diagnostic, semen, haematological and liver function tests and blood level of IL-2. The mean TS levels were at the lowest limit of normal range for liver cirrhotic patients. Mean E2 levels were increased in all patients, but patients with liver cirrhosis-related schistosomiasis had higher E2 levels. Linear regression analysis showed that the sex hormone levels correlated best with the patient's liver function parameters. The present data suggest that a sex hormone imbalance plays a role in patients with liver cirrhosis due to the inhibitory effects of schistosomiasis on gonadal functions.
authors.affiliation: Department of Zoology, Faculty of Science, Cairo University, Egypt.
authors.forename: A H
authors.initials: AH
authors.lastname: Saad
authors.forename: A
authors.initials: A
authors.lastname: Abdelbaky
authors.forename: A M
authors.initials: AM
authors.lastname: Osman
authors.forename: K F
authors.initials: KF
authors.lastname: Abdallah
authors.forename: D
authors.initials: D
authors.lastname: Salem
mesh_terms: D000818:Animals; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000209:etiology* / Q000473:pathology; D008297:Male; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000150:complications* / Q000469:parasitology
chemical_list: D012739:Gonadal Steroid Hormones