title: Exiting an RNA world.
abstract: The RNA world hypothesis gains support from the in vitro evolution of a bifunctional ribozyme that can recognize an activated glutaminyl ester and subsequently aminoacylate a tRNA molecule.
authors.forename: P
authors.initials: P
authors.lastname: Schimmel
authors.forename: S O
authors.initials: SO
authors.lastname: Kelley
mesh_terms: D000215:Acylation; D000596:Amino Acids / Q000378:metabolism; D000604:Amino Acyl-tRNA Synthetases / Q000378:metabolism; D002384:Catalysis; D019143:Evolution, Molecular; D005815:Genetic Code / Q000235:genetics; D016337:RNA, Catalytic / Q000235:genetics / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism*; D013379:Substrate Specificity
chemical_list: D000596:Amino Acids; D016337:RNA, Catalytic; D012346:RNA, Transfer, Amino Acyl; D012343:RNA, Transfer; D000604:Amino Acyl-tRNA Synthetases