Lack of benefit of intravenous immune globulin in a murine model of group A streptococcal necrotizing fasciitis.
Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P<.05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P=.02), penicillin/clindamycin (P=.009), clindamycin/IVIG (P=.04), or all agents combined (P=.02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.
Patel
R
R
Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA. patel.robin@mayo.edu
Rouse
M S
MS
Florez
M V
MV
Piper
K E
KE
Cockerill
F R
FR
Wilson
W R
WR
Steckelberg
J M
JM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D019115:Fasciitis, Necrotizing / Q000188:drug therapy*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000627:therapeutic use*; D013297:Streptococcus pyogenes / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D016756:Immunoglobulins, Intravenous; D010406:Penicillins; D002981:Clindamycin