title: Ethylene glycol intoxication: pathophysiology, diagnosis, and emergency management.
abstract: Acute ethylene glycol intoxication is a medical emergency that, if not diagnosed correctly and treated aggressively, will lead to serious neurologic, cardiopulmonary, and renal dysfunction, and may result in death. Ethylene glycol toxicity is characterized by severe metabolic acidosis with high anion and osmolal gaps, and calcium oxalate crystals in the urine. Early recognition of ethylene glycol intoxication and rapid, aggressive use of large amounts of sodium bicarbonate, ethanol infusion, and hemodialysis may improve survival.
authors.affiliation: Vanderbilt Dialysis Clinic, Nashville, TN, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Egbert
authors.forename: K
authors.initials: K
authors.lastname: Abraham
mesh_terms: D000138:Acidosis / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D000208:Acute Disease; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D003937:Diagnosis, Differential; D016529:Emergency Nursing / Q000379:methods; D004638:Emergency Treatment / Q000379:methods* / Q000451:nursing*; D019855:Ethylene Glycol / Q000506:poisoning*; D006801:Humans; D011041:Poisoning / Q000150:complications / Q000175:diagnosis / Q000628:therapy
chemical_list: D019855:Ethylene Glycol