title: Gross type-matched study of clinicopathologic features of advanced gastric carcinoma with replication error.
abstract: Sporadic gastric carcinomas with replication error (RER) have been described and have distinct clinicopathological features, such as: older age group, predominant antral location, elevated gross type, near-diploidy, expanding pattern (Ming's classification), intestinal type, low desmoplastic response, and less frequent lymph node metastasis. Previous study revealed that replication error-positive (RER+) advanced gastric carcinomas (AGC) had a preponderance of Borrmann type 2. Regardless of RER status, AGC of Borrmann type 2 usually exhibit expanding pattern (Ming's classification), intestinal type, and low desmoplastic reaction. Therefore, to better characterize the clinicopathological features of RER+ gastric carcinomas, gross type-matched analysis would be necessary. We analyzed 53 cases of Borrmann type 2 AGC for RER status using polymerase chain reaction analysis of eight microsatellite loci and compared the clinicopathological features between RER+ and RER-negative (RER-) tumors. Sixteen (30.2%) out of 53 cases were RER+ phenotype which had a significant association with female sex, older age, expanding pattern, small and uniform nuclei, and low DNA index (P < 0.05). However, RER status was not significantly associated with histological differentiation, histological type (Lauren's classification), desmoplastic response, intratumoral lymphoid infiltration, and tumor location. Most of the previously known clinicopathological features of RER+ AGC were related to Borrmann type 2, except for female sex, older age, expanding pattern, and low DNA index.
authors.affiliation: Department of Diagnostic Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. ghkang@www.amc.seoul.kr
authors.forename: G H
authors.initials: GH
authors.lastname: Kang
authors.forename: B H
authors.initials: BH
authors.lastname: Kim
authors.forename: T J
authors.initials: TJ
authors.lastname: Lee
authors.forename: Y H
authors.initials: YH
authors.lastname: Shim
authors.forename: G
authors.initials: G
authors.lastname: Gong
authors.forename: J Y
authors.initials: JY
authors.lastname: Ro
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000145:classification / Q000235:genetics / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000145:classification / Q000235:genetics / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D004261:DNA Replication / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D011003:Ploidies; D013274:Stomach Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*
chemical_list: D004273:DNA, Neoplasm