title: Nephrogenic diabetes insipidus in a dog with intestinal leiomyosarcoma.
abstract: Nephrogenic diabetes insipidus was diagnosed in a dog with an intestinal leiomyosarcoma. The diagnosis of nephrogenic diabetes insipidus was made on the basis of results of serum biochemical tests, urinalyses, and a water-deprivation test, along with a lack of response to exogenous administration of vasopressin following the water-deprivation test. The temporal association between resection of the intestinal mass and resolution of clinical signs of diabetes insipidus (i.e., polyuria and polydipsia) and between recurrence of clinical signs and detection of metastatic disease suggests that there may have been a causal relationship, and nephrogenic diabetes insipidus may have developed as a paraneoplastic syndrome in this dog.
authors.affiliation: Animal Medical Center, New York, NY 10021, USA.
authors.forename: M
authors.initials: M
authors.lastname: Cohen
authors.forename: G S
authors.initials: GS
authors.lastname: Post
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003894:Deamino Arginine Vasopressin / Q000627:therapeutic use; D018500:Diabetes Insipidus, Nephrogenic / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D007414:Intestinal Neoplasms / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D007890:Leiomyosarcoma / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D011860:Radiography, Abdominal / Q000662:veterinary; D012076:Renal Agents / Q000627:therapeutic use; D013046:Specific Gravity / Q000187:drug effects; D014463:Ultrasonography / Q000662:veterinary
chemical_list: D000970:Antineoplastic Agents; D012076:Renal Agents; D004317:Doxorubicin; D003894:Deamino Arginine Vasopressin