[Molecular and cellular mechanisms of the adaptive response in eukaryotes].
The mechanisms of adaptive response (AR) which consisted of the increasing of cell and organism resistance to large doses of genotoxic and toxic agents formed after the preliminary influencing of its agents in small doses were discussed. The examples of factors leading to AR (irradiation, radiomimetics, alkylators, H2O2, and hyperthermy) as well as the conditions of its manifestation (in vivo and in vitro, acute and chronic adapting influences) were produced. The AR mechanisms bases on the molecular and cellular levels are the stimulation of protecting system (the synthesis of protecting proteins and antioxidant system activation), the intensification of DNA repair, effect on neurohumoral signal messengers and changes of proliferative activity. On organism level the nonspecific stress-reaction components were added (AKTG and steroid hormones synthesis). It was concluded that no there was no single mechanism of AR to all type of damaging agents. Evidently of that causes of its phenomenon have the complex character. The relatively narrow limits of AR (variability for the cells of different individuals, slight AR in children's cells and full absence of embryo cells) require careful use an AR conformities as the indicator for the professional and referring works.
Koterov
A N
AN
Russian Industrial Center, Institute of Biophysics, Moscow.
Nikol'skiĭ
A V
AV
D000222:Adaptation, Physiological; D000818:Animals; D006801:Humans; D018384:Oxidative Stress