title: Non-invasive assessment of renal artery stenosis: current concepts and future directions in magnetic resonance angiography.
abstract: Magnetic resonance angiography is undergoing rapid development as a non-invasive technique to reliably assess renal artery stenosis. Invasive X-ray angiography is currently the gold standard imaging technique and gives excellent spatial resolution. However, its disadvantages include a necessary exposure to radiation and the need for iodinated contrast media. While magnetic resonance angiography does not have these disadvantages, its spatial resolution is inherently lower. On the other hand, magnetic resonance angiography enables true three-dimensional imaging. The use of rapid imaging techniques allows multiple image acquisition within one breath-hold thereby permitting the visualization of distinct vascular phases. The limitation in spatial resolution can be overcome readily by combining morphologic imaging with functional information on the hemodynamic relevance. This can be achieved by means of magnetic resonance phase contrast flow measurements. The use of such a combined approach enables the grading of vascular stenosis based on the combination of morphology and functional information. Magnetic resonance angiography is already able to demonstrate a clinical utility equivalent to that of invasive procedures, indicating that it is likely to become a premier method for the diagnosis and follow up of renovascular disease.
authors.affiliation: Forschungsschwerpunkt Radiologische Diagnostik und Therapie, Deutsches Krebsforschungszentrum (dkfz), Heidelberg, Germany. M.Knopp@dkfz-heidelberg.de
authors.forename: M V
authors.initials: MV
authors.lastname: Knopp
authors.forename: F
authors.initials: F
authors.lastname: Floemer
authors.forename: S O
authors.initials: SO
authors.lastname: Schoenberg
authors.forename: H
authors.initials: H
authors.lastname: von Tengg-Kobligk
authors.forename: M
authors.initials: M
authors.lastname: Bock
authors.forename: G
authors.initials: G
authors.lastname: van Kaick
mesh_terms: D015901:Angiography, Digital Subtraction; D001783:Blood Flow Velocity; D003287:Contrast Media / Q000008:administration & dosage; D005544:Forecasting; D005682:Gadolinium / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D018810:Magnetic Resonance Angiography / Q000379:methods* / Q000639:trends; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000473:pathology*; D012078:Renal Artery Obstruction / Q000175:diagnosis* / Q000503:physiopathology; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005682:Gadolinium