Delta opioid binding selectivity of 3-ether analogs of naltrindole.
Masking of the 3-phenol of naltrindole as a range of ethers caused a decrease in binding affinity at all three opiate receptors (mu, kappa, delta), however for the methyl ether, the reduction in affinity at both mu and kappa was greater than at delta, thereby increasing delta binding selectivity.
Coop
A
A
Laboratory of Medicinal Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, MD 20892, USA.
Pinto
J
J
Wang
L
L
McCullough
K
K
Rothman
R B
RB
Dersch
C
C
Jacobson
A E
AE
Rice
K C
KC
D009271:Naltrexone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D009292:Narcotic Antagonists / Q000737:chemistry / Q000378:metabolism*; D011485:Protein Binding; D017465:Receptors, Opioid, delta / Q000378:metabolism*
D009292:Narcotic Antagonists; D017465:Receptors, Opioid, delta; D009271:Naltrexone; C055382:naltrindole