title: [Penile lichen sclerosus: follow-up study].
abstract: BACKGROUND
  The aim of this work was to study the long-term course of patients with penile lichen sclerosus and atrophicus.
  
  
  METHODS
  We reviewed the files of 16 patients followed at our university center from 1982 to 1997 for pathologically proven penile lichen sclerosus and atrophicus. Age at disease onset, duration of the disease course, presence of a triggering factor, initial localization, signs and symptoms, treatment given and its efficacy were recorded.
  
  
  RESULTS
  Mean age at diagnosis was 52 years. Inaugural prepuce localizations were observed in 6 cases, involving the distal part of the penis and the glan in 3 cases. Concomitant involvement of the glan and the balanopreputial groove were seen in 6 cases. The localization was limited to the glan in one case. Six patients underwent posthectomy and one had dorsal plasty of the prepuce. The 9 other patients were treated medically with topical corticosteroids and/or androgens. One patient had died prior to evaluation. Among the 9 patients given medical treatment, lichen sclerosus persisted in 7, one developed a squamous cell carcinoma of the penis and one was cured. Among the 6 cases of surgical treatment, 5 were cured and 1 had persistent lesions. Considering the initial localization, long-term course showed that 7 of the 8 patients with a prepuce localization (alone or in association with glan involvement) were cured while the 7 patients with a lesion of the balanopreputial groove (alone or in association with glan involvement) or a lesion of the glan alone still had lichen sclerosus and atrophicus. The non parametric Fischer test showed that the chances of cure were better for preputial localizations than for balanopreputial localizations (p = 0.001) and that surgical treatment was more effective than medical treatment.
  
  
  CONCLUSIONS
  This study of a small number of patients highlighted two points: prepuce localizations of lichen sclerosus and atrophicus cure better than balanopreputial localizations, and that medical treatment is partially effective in balanopreputial localizations. One patient developed squamous cell carcinoma of the penis. As the level of the cancer risk remains unknown, it would be important to provide the most effective treatment in all cases of penis lichen sclerosus and atrophicus.
authors.affiliation: Service de Dermatologie, CHU Dupuytren, 87042 Limoges Cedex, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Bouyssou-Gauthier
authors.forename: S
authors.initials: S
authors.lastname: Boulinguez
authors.forename: J P
authors.initials: JP
authors.lastname: Dumas
authors.forename: C
authors.initials: C
authors.lastname: Bedane
authors.forename: J M
authors.initials: JM
authors.lastname: Bonnetblanc
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000628:therapy*; D012189:Retrospective Studies