title: Usefulness of the response of flow velocity in the left anterior descending coronary artery to the cold pressor test for evaluating endothelium-dependent vascular relaxation in the coronary microvasculature by transesophageal echocardiography in subjects with angiographically normal coronary arteries.
abstract: Measurement of flow velocity in the left anterior descending coronary artery by transesophageal echocardiography in subjects without risk factors for coronary artery disease (group 1) and in subjects with normal coronary arteries but conditions associated with endothelial dysfunction (group 2) revealed that there was a significantly impaired coronary flow velocity response to the cold pressor test in group 2 subjects. Thus, transesophageal echocardiography provides a minimally invasive tool for the functional assessment of endothelium and can be valuable in evaluating endothelial dysfunction and recovery in a variety of disease states.
authors.affiliation: Division of Cardiology, Los Angeles County-University of Southern California Medical Center, University of Southern California School of Medicine, 90033, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Chandraratna
authors.forename: A R
authors.initials: AR
authors.lastname: Nimalasuriya
authors.forename: K D
authors.initials: KD
authors.lastname: Vlachonassios
authors.forename: S J
authors.initials: SJ
authors.lastname: Mathews
authors.forename: W
authors.initials: W
authors.lastname: Kedes
authors.forename: O S
authors.initials: OS
authors.lastname: Marwah
authors.forename: M
authors.initials: M
authors.lastname: Saad
mesh_terms: D000241:Adenosine / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000187:drug effects; D003080:Cold Temperature; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000175:diagnosis; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D018618:Echocardiography, Doppler, Color; D017548:Echocardiography, Transesophageal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014665:Vasodilator Agents; D000241:Adenosine