Aerosol therapy for asthma.
Inhaled drugs play an important role in asthma management. The correct use of an appropriate delivery device is necessary to achieve the desired therapeutic effects of the drug. Currently, chlorofluorocarbon-propelled metered-dose inhalers, with or without spacers, are the most popular aerosol delivery devices. With the planned phase out of the chlorofluorocarbon metered-dose inhalers, the use of other delivery devices is being emphasized. To achieve optimal therapeutic effects, the drug and the delivery device should be considered a "couple". Aerosol delivery devices should provide an adequate "drug dose to the lung", be cost effective, simple to operate, minimize oropharyngeal deposition and systemic side effects, and match the patient's requirements. A new generation of aerosol delivery devices, incorporating the latest advances in aerosol technology, is likely to fulfill many of the goals mentioned above.
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Division of Pulmonary and Critical Care Medicine, Stritch School of Medicine, Loyola University of Chicago, IL, USA.
D000280:Administration, Inhalation; D000336:Aerosols; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D017402:Chlorofluorocarbons; D003362:Cost-Benefit Analysis; D016503:Drug Delivery Systems; D004867:Equipment Design; D006801:Humans; D008168:Lung / Q000187:drug effects; D009330:Nebulizers and Vaporizers / Q000191:economics
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D017402:Chlorofluorocarbons