Application of low-intensity ultraviolet irradiation to the treatment for pharmacological vasoconstriction via a percutaneous transluminal approach.
We applied low-power ultraviolet (UV) laser irradiation via a thin flexible optical fiber to an in vivo model of vasospasm using an intravascular transluminal approach. The surgically exposed left femoral arteries of a rabbit were constricted by norepinephrine. A quartz fiber of 400 microm in diameter was introduced into the artery via the right common carotid artery through a 2.5F catheter. The femoral artery lumen was then irradiated with a helium-cadmium laser (wavelength 325 nm, output power 8 mW) through the fiber for 30 s. The UV irradiation increased the mean luminal diameter by 85% in comparison to the precontracted state, while the increase was only 45% in a sham operation. A histopathologic examination revealed no thermal damage and an intact internal elastic lamina. These results suggest that intravascular transluminal irradiation with a low-power UV laser may thus have potentially clinical applications to reverse acute arterial vasospasm.
Nakai
K
K
Department of Medical Engineering, National Defense Medical College, Saitama, Japan.
Morimoto
Y
Y
Arai
T
T
Ito
H
H
Kominami
M
M
Matsuo
H
H
Kikuchi
M
M
D000792:Angiography; D000818:Animals; D004730:Endothelium, Vascular / Q000473:pathology; D005263:Femoral Artery / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects*; D053685:Laser Therapy; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D009336:Necrosis; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D014467:Ultraviolet Therapy; D014652:Vascular Diseases / Q000139:chemically induced / Q000503:physiopathology / Q000532:radiotherapy*; D014661:Vasoconstriction / Q000528:radiation effects*
D009638:Norepinephrine