Angiotropic large B-cell lymphoma with clinical features resembling subacute combined degeneration of the cord.
Angiotropic large cell lymphoma is a rare neoplastic disorder associated with a high mortality. The hallmark of the disease is lymphoid proliferation confined to the intravascular compartment without local tissue or vessel wall infiltration [1]. This feature is so striking that the disease was originally thought to arise from endothelial tissue and early cases were described as malignant angioendotheliomatosis. However, application of immunohistochemical methods for detection of lymphoid markers such as the CD45 and CD20 cell surface markers has confirmed its lymphoid origin, usually of B-cell lineage [2]. Clinical manifestations of the disease are protean and are due to multifocal medium and small vessel occlusion by tumour cells [3]. Characteristic sites of involvement are skin and central nervous system and although an ante-mortem diagnosis can be made from a biopsy specimen, it is often unsuspected [4]. We present a case of angiotropic large B-cell lymphoma in a 74-year-old man who presented with urinary symptoms and had a neurological picture resembling subacute combined degeneration of the cord.
Waring
W S
WS
Clinical Pharmacology Unit, University of Edinburgh, Western General Hospital, UK.
Wharton
S B
SB
Grant
R
R
McIntyre
M
M
D000368:Aged; D002490:Central Nervous System / Q000098:blood supply; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000209:etiology; D013120:Spinal Cord Neoplasms / Q000175:diagnosis*; D016055:Urinary Retention / Q000209:etiology