Tokaramide A, a new cathepsin B inhibitor from the marine sponge Theonella aff. mirabilis.
A new cathepsin B inhibitor, tokaramide A (1) has been isolated from the marine sponge Theonella aff. mirabilis. Its structure was determined by spectroscopic and chemical methods. Tokaramide A inhibits cathepsin B with an IC50 value of 29.0 ng/mL.
Fusetani
N
N
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Fujita
M
M
Nakao
Y
Y
Matsunaga
S
S
Van Soest
R W
RW
D000818:Animals; D002401:Cathepsin B / Q000037:antagonists & inhibitors*; D002851:Chromatography, High Pressure Liquid; D015853:Cysteine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism
D015853:Cysteine Proteinase Inhibitors; D009842:Oligopeptides; C403246:tokaramide A; D002401:Cathepsin B