title: Efficacy of moxidectin against sarcoptic mange and effects on milk yield of ewes and growth of lambs.
abstract: Forty-eight dairy ewes and 45 lambs naturally infested with sarcoptic mange, were divided into three equal groups and treated with moxidectin 1% inj. sol. at a dose rate of 0.2 mg moxidectin kg(-1) bodyweight once or twice ten days apart. During the study, the skin lesions were scored and the number of mites recovered in facial skin scrapings from the animals were recorded. Moxidectin was found to be effective against ovine sarcoptic mange, when given twice; the percentage reduction of mites was 100% (p < 0.0001) and the skin lesions disappeared completely (p = 0.0001). In sheep treated once only, the percentage reduction of mites varied from 75% to 92%. Treated ewes produced up to 22.4% more milk than the infested ones (p = 0.0001). Treated lambs had up to 15% greater final weight and up to 23.7% more growth than infested controls (p = 0.0001). It is concluded that two injections of moxidectin 1% inj. sol. at a dose rate of 0.2 mg kg(-1) bodyweight, given ten days apart, were effective against ovine sarcoptic mange. Furthermore, it is considered that sarcoptic mange adversely affects the production of the infested animals.
authors.affiliation: Veterinary Faculty, University of Thessaly, Karditsa, Greece. gcf@vet.uth.gr
authors.forename: G C
authors.initials: GC
authors.lastname: Fthenakis
authors.forename: E
authors.initials: E
authors.lastname: Papadopoulos
authors.forename: C
authors.initials: C
authors.lastname: Himonas
authors.forename: L
authors.initials: L
authors.lastname: Leontides
authors.forename: S
authors.initials: S
authors.lastname: Kritas
authors.forename: J
authors.initials: J
authors.lastname: Papatsas
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight; D005260:Female; D007267:Injections / Q000662:veterinary; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007774:Lactation; D018942:Macrolides; D008892:Milk / Q000378:metabolism; D012520:Sarcoptes scabiei / Q000254:growth & development*; D012532:Scabies / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012867:Skin / Q000469:parasitology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin