title: Age-related decline in DHEAS is not related to cognitive impairment in aged monkeys.
abstract: To determine whether endogenous DHEAS level is related to cognitive performance in the rhesus monkey, we tested 9 young and 14 old monkeys on the acquisition and the 120 s delay condition of the delayed non-matching to sample and on the spatial delayed recognition span test. A single summary measure of cognitive ability, the cognitive performance index (CPI), was derived from these three tests. As expected, the mean level of DHEAS as well as the CPI declined with age. DHEAS level, however, was not significantly correlated with CPI, after controlling for the relationship of age to these two variables. Further, impaired and unimpaired aged monkeys did not differ in DHEAS level. These findings suggest that DHEAS is not independently associated with age-related cognitive decline in the rhesus monkey.
authors.affiliation: Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Herndon
authors.forename: A
authors.initials: A
authors.lastname: Lacreuse
authors.forename: E
authors.initials: E
authors.lastname: Ladinsky
authors.forename: R J
authors.initials: RJ
authors.lastname: Killiany
authors.forename: D L
authors.initials: DL
authors.lastname: Rosene
authors.forename: M B
authors.initials: MB
authors.lastname: Moss
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D003071:Cognition / Q000502:physiology*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D008253:Macaca mulatta / Q000097:blood* / Q000502:physiology* / Q000523:psychology; D008297:Male; D009483:Neuropsychological Tests; D013223:Statistics as Topic
chemical_list: D019314:Dehydroepiandrosterone Sulfate