Thyrotropin releasing hormone stimulation of GABA-gated but not basal chloride ion influx in rat cerebellum.
Potential interaction between gamma-amino butyric acid (GABA) and thyrotropin-releasing hormone (TRH) in eliciting a variety of central nervous system (CNS)-related biologic activities is well known; however, the mechanism underlying this interaction is not clearly defined. To gain further insight into this interaction, we examined the effects of TRH and two of its central nervous system selective analogs, DN 1417 and TA 0910, on basal and GABA-mediated chloride ion influx into rat cerebellar neurosynaptosomes. The results of these studies show that TRH may facilitate GABA action by augmenting chloride ion influx and hyperpolarization of cerebellar neurons.
Imamura
M
M
Department of Medicine, Louisiana State University Medical Center, New Orleans, LA 70112, USA.
Yamada
M
M
Mori
M
M
Prasad
C
C
D000818:Animals; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D015640:Ion Channel Gating / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013574:Synaptosomes / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D002712:Chlorides; C065049:TA 0910; D005680:gamma-Aminobutyric Acid; D013973:Thyrotropin-Releasing Hormone; C029762:DN 1417