Preliminary studies of analgesic and anti-inflammatory properties of Opuntia dillenii aqueous extract.
Opuntia dillenii (Ker-Gawl) Haw is a cactus that belongs to the family Opuntiae. Lyophilized aqueous extract of the fruits of the plant, used in Canarian traditional medicine for gastrointestinal and bronchial troubles, was evaluated for analgesic and anti-inflammatory properties in rats and mice. The Opuntia dillenii extract (100-400 mg/kg, i.p.) inhibited, in a dose-related manner, carrageenan-induced paw edema in rats. A dose-dependent action was obtained against chemical (writhing test) and thermic (hot plate test) stimuli, respectively, with doses of 50 and 100 mg/kg.
Loro
J F
JF
Department of Pharmacology, Faculty of Health Sciences, University of Las Palmas, Las Palmas de Gran Canaria, Spain.
del Rio
I
I
Pérez-Santana
L
L
D019342:Acetic Acid / Q000009:adverse effects / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002351:Carrageenan / Q000037:antagonists & inhibitors / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013030:Spain
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid