title: Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting.
abstract: A modular system for high-output solid-phase combinatorial synthesis has been designed and developed. The system employs three technological innovations to achieve its high efficiency and reliability: (1) application of microreactors as the reaction units in solid-phase synthesis; (2) use of radiofrequency tagging as the non-chemical tracking method; and (3) development of the directed sorting technology for split & pool synthesis. The system has been successfully applied in the synthesis of compound libraries of several hundred to several thousand compounds in multi-milligrams per compound quantity by many organizations.
authors.affiliation: IRORI, a Discovery Partners International Company, 9640 Towne Centre Drive, San Diego, California 92121, USA.
authors.forename: X Y
authors.initials: XY
authors.lastname: Xiao
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Zhuang
authors.forename: B
authors.initials: B
authors.lastname: Ewing
authors.forename: K
authors.initials: K
authors.lastname: Karunaratne
authors.forename: J
authors.initials: J
authors.lastname: Lillig
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
mesh_terms: D002625:Chemistry, Organic / Q000295:instrumentation* / Q000379:methods; D019992:Databases as Topic; D015195:Drug Design; D007202:Indicators and Reagents; D009930:Organic Chemicals / Q000138:chemical synthesis*; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000138:chemical synthesis; D011846:Radio Waves; D012116:Resins, Plant
chemical_list: D007202:Indicators and Reagents; D009930:Organic Chemicals; D012116:Resins, Plant; D017239:Paclitaxel