Review of factors susceptible of influencing post-mortem carbohydrate-deficient transferrin.
Seric carbohydrate-deficient transferrin (CDT) is a biochemical marker of chronic alcohol abuse. Assessment of the influence of factors likely to modify CDT concentration is necessary to justify its use in the analysis of post-mortem blood samples. Hemolysis, site of collection and storage were tested. Hemolysed samples showed decreased CDT concentration. Statistical analysis of CDT concentration in cardiac blood versus femoral blood revealed no significant differences. Storage for fifteen days at +4 degrees C or +20 degrees C did not affect CDT concentration but repeated freezing and thawing resulted in decreased levels of CDT.
Simonnet
C
C
Laboratoire Ruffié, Tourny, Bordeaux, France. simonnet@proxilab.com
Dumestre-Toulet
V
V
Kintz
P
P
Gromb
S
S
D000437:Alcoholism / Q000097:blood*; D001793:Blood Preservation; D005554:Forensic Medicine; D005615:Freezing; D006461:Hemolysis; D006801:Humans; D011180:Postmortem Changes; D015203:Reproducibility of Results; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism
D014168:Transferrin; C056759:carbohydrate-deficient transferrin