Estrogen and progesterone receptor-negative T11 vertebral hemangioma presenting as a postpartum compression fracture: case report and management.
OBJECTIVE
Pregnancy-related vertebral hemangioma compressive myelopathy is a rare occurrence that tends to arise in the upper thoracic and lower cervical spine, peaks during the third trimester, and remits after parturition. Whether corticosteroid receptors play a role in the pathogenesis of these lesions is unknown. Most of these lesions have been managed with posterior decompression.


METHODS
A 29-year-old woman presented with acute-onset lower-extremity weakness and sensory loss immediately after parturition.


METHODS
We used a retropleural approach for anterior decompression and fusion, followed by radiation therapy. Immunohistochemical analysis of estrogen and progesterone receptor expression was performed.


CONCLUSIONS
We report an unusual case of lower thoracic postpartum vertebral hemangioma compressive myelopathy caused by a parturition-related compression fracture. Results of tests for corticosteroid receptors were negative, which implicated a hemodynamic rather than hormonal cause for disease progression.
Schwartz
T H
TH
Department of Neurological Surgery, The Neurological Institute of New York, New York Presbyterian Medical Center, 10032, USA.
Hibshoosh
H
H
Riedel
C J
CJ
D000328:Adult; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology*; D006391:Hemangioma / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D011644:Puerperal Disorders / Q000209:etiology*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013117:Spinal Cord Compression / Q000209:etiology*; D016103:Spinal Fractures / Q000209:etiology*; D013125:Spinal Neoplasms / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis*; D013904:Thoracic Vertebrae
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone