title: Pineal malignant rhabdoid tumor with chondroid formation in an adult.
abstract: A pineal tumour in a 27-year-old male is presented with the characteristic histological features of a pineal malignant rhabdoid tumor (MRT) with chondroid formation. Occasionally, tumor cells contained a single well-demarcated hyaline globular inclusion within the cytoplasm adjacent to the nucleus. The stroma of these tumors tends to be densely hyalinized and become chondroid. Immunohistochemical staining was positive for vimentin, epithelial membrane antigen, chromogranin A, synaptophysin, neuron-specific enolase, S-100 protein, and muscle actin. Despite surgery and radiochemotherapy, the tumor recurred in the pineal region and metastasized to the lower lobe of right lung. The patient died 2 years after the initial diagnosis. This is the second published case of central nervous system-MRT appearing in an adult. The clinical and pathological features of pineal MRT in this patient are presented.
authors.affiliation: Department of Pathology, Kurume University School of Medicine, Kurume, Japan. sagitaoy@med.kurume-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: I
authors.initials: I
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Morimatsu
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Shigemori
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D020219:Chondrogenesis; D003131:Combined Modality Therapy; D003399:Craniotomy; D017809:Fatal Outcome; D006801:Humans; D007124:Immunoenzyme Techniques; D008175:Lung Neoplasms / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008297:Male; D015376:Nimustine / Q000627:therapeutic use; D010871:Pinealoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D013902:Radiography, Thoracic; D018714:Radiotherapy, Adjuvant; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D015376:Nimustine