title: Relation of basic and clinical research on foetal and neonatal thyroid pathology to neonatal thyroid screening.
abstract: In this short review the importance is emphasized of basic and clinical research in regard to the interpretation of screening results. This review covers foetal thyroid physiology during the first 48 h of life, the importance of thyroid hormones for normal brain development, the definition of a critical period which might explain intellectual abnormalities in 10-15% of detected hypothyroid children and the importance of autoimmunity in the aetiology and diagnosis of transient congenital hypothyroidism.
authors.affiliation: Research Unit in Human Genetics, Research Center, CHUQ, Ste-Foy, Quebec, Canada. jean.h.dussault@crchul.ulaval.ca
authors.forename: J H
authors.initials: JH
authors.lastname: Dussault
mesh_terms: D000818:Animals; D015551:Autoimmunity; D002170:Canada; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000503:physiopathology*; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology; D015997:Neonatal Screening; D011247:Pregnancy; D051381:Rats; D012107:Research Design; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*
chemical_list: D013963:Thyroid Hormones