title: Hypoxia, ischemic stroke, and memory deficits: prospects for therapy.
abstract: Oxygenation of cells and tissues in mammals according to metabolic needs is always a life-or-death necessity. Over the last decade, life scientists have gained an impressive understanding of cellular and molecular mechanisms in hypoxic-ischemic injury and memory deficits, survival, and death. Functional recovery from hypoxia-ischemia depends on how the individual responds to the insult, and whether appropriate responses are initiated and maintained. Unraveling the biochemical and molecular mechanisms and responses of hypoxia-ischemia is likely to dramatically shape and improve medical practice in the treatments of hypoxia-ischemia and memory deficits.
authors.affiliation: Laboratory of Adaptive Systems, National Institute of Neurological Disorders and Stroke/NIH, Bethesda, MD 20892, USA. mksun@codon.nih.gov
authors.forename: M K
authors.initials: MK
authors.lastname: Sun
mesh_terms: D000818:Animals; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D020521:Stroke / Q000150:complications / Q000378:metabolism / Q000473:pathology / Q000628:therapy*