Synthesis and sorting of proteoglycans.
Proteoglycans are widely expressed in animal cells. Interactions between negatively charged glycosaminoglycan chains and molecules such as growth factors are essential for differentiation of cells during development and maintenance of tissue organisation. We propose that glycosaminoglycan chains play a role in targeting of proteoglycans to their proper cellular or extracellular location. The variability seen in glycosaminoglycan chain structure from cell type to cell type, which is acquired by use of particular Ser-Gly sites in the protein core, might therefore be important for post-synthesis sorting. This links regulation of glycosaminoglycan synthesis to the post-Golgi fate of proteoglycans.
Prydz
K
K
Department of Biochemistry and Institute for Nutrition Research, University of Oslo, Norway. kristian.prydz@biokjemi.uio.no.
Dalen
K T
KT
D000595:Amino Acid Sequence; D000818:Animals; D002240:Carbohydrate Sequence; D016764:Cell Polarity; D002809:Chondroitin Sulfates / Q000096:biosynthesis; D003871:Dermatan Sulfate / Q000096:biosynthesis; D004847:Epithelial Cells / Q000378:metabolism; D006025:Glycosaminoglycans / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006493:Heparin / Q000096:biosynthesis; D006497:Heparan Sulfate / Q000096:biosynthesis; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000737:chemistry; D011509:Proteoglycans / Q000096:biosynthesis* / Q000737:chemistry / Q000378:metabolism
D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006493:Heparin; D006497:Heparan Sulfate; D009844:Oligosaccharides; D011509:Proteoglycans