title: Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans.
abstract: The clustered prnB, prnC, and prnD genes are repressed by the simultaneous presence of glucose and ammonium. A derepressed mutation inactivating a CreA-binding site acts in cis only on the permease gene (prnB) while derepression of prnD and prnC is largely the result of reversal of inducer exclusion.
authors.affiliation: Institut de Génétique et Microbiologie, Université Paris-Sud, UMR CNRS C8621, 91405 Orsay Cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Cubero
authors.forename: D
authors.initials: D
authors.lastname: Gómez
authors.forename: C
authors.initials: C
authors.lastname: Scazzocchio
mesh_terms: D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D001233:Aspergillus nidulans / Q000235:genetics* / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005810:Multigene Family; D009154:Mutation; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics / Q000378:metabolism; D011392:Proline / Q000235:genetics* / Q000378:metabolism*; D011394:Proline Oxidase / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C079728:AreA protein, Aspergillus nidulans; D005656:Fungal Proteins; D014157:Transcription Factors; D011392:Proline; D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011394:Proline Oxidase