Glucose regulates pancreatic preprosomatostatin I expression.
Rainbow trout were used as a model system to evaluate the role of glucose in regulating the expression of preprosomatostatin I. Glucose increased pancreatic levels of preprosomatostatin I mRNA in vivo, in concert with elevated plasma somatostatin levels, and in vitro. Glucose-stimulated expression of preprosomatostatin I mRNA required the uptake, phosphorylation, and subsequent metabolism of the sugar in pancreatic islets. These results suggest that glucose modulates both the production and release of somatostatin.
Melroe
G T
GT
Department of Zoology and Regulatory Biosciences Center, North Dakota State University, Fargo, ND 58105, USA.
Ehrman
M M
MM
Kittilson
J D
JD
Sheridan
M A
MA
D000818:Animals; D005786:Gene Expression Regulation / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology*; D017686:Oncorhynchus mykiss; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D013004:Somatostatin / Q000235:genetics*
D011498:Protein Precursors; D012333:RNA, Messenger; D013004:Somatostatin; D005947:Glucose