Plasminogen Activator Inhibitor 1: Molecular Aspects and Clinical Importance.
Plasminogen activator inhibitor-1 (PAI-1) is the major physiologic inhibitor of plasminogen activation in plasma and in the blood vessel wall. PAI-1 exhibits distinctive structural and functional properties that have been extensively studied over the past decade. Aside from the physiological role of PAI-1, there is accumulating evidence that increased production of PAI-1 may contribute to the development of ischemic cardiovascular disease. Efforts are now underway to develop and test specific inhibitors of PAI-1.
Vaughan
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Cardiology Division, Vanderbilt University Medical Center, Medical Research Bldg. II, Rm. 315, Nashville, TN 37232-6300.