[Cord blood insulin level in relation to metabolic control of maternal diabetes, duration of pregnancy and neonatal birth weight].
The aim of the study was to examine whether an association between cord blood insulin level (Ic) and maternal glycemic control, duration of pregnancy as well as neonatal birthweight exists. The study was performed in diabetic group consisted of 149 diabetic mothers (91 with GDM and 58 with IDDM) and 149 their babies as well as in the control group consisted of 100 healthy mothers and 100 their babies. Maternal glycemic control was indirectly assessment by using HbA1c and fructosamine levels estimated on the day of delivery. That was found a significant positive correlation between Ic and maternal HbA1c and fructosamine levels as well as between Ic and neonatal birthweight in the diabetic group. That was also found the significant negative correlation between Ic and duration of pregnancy in the diabetic group. We conclude that fetal hyperinsulinemia is a result of poor glycemic control during the last weeks of diabetic pregnancy. Furthermore the significant association exists between cord blood hyperinsulinemia and preterm delivery as well as higher birthweight of newborns born to diabetic mothers.
Czeszyńska
M B
MB
Kliniki Neonatologii IPG PAM w Szczecinie.
Celewicz
Z
Z
Ogonowski
J
J
D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000517:prevention & control*; D016640:Diabetes, Gestational / Q000517:prevention & control*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007328:Insulin / Q000032:analysis*; D011247:Pregnancy; D011248:Pregnancy Complications; D013997:Time Factors
D007328:Insulin