[Prospective neurological analysis of development of children of mothers with IDDM].
Aim of the study was early diagnosis of CNS damage and dysfunction in the progeny of women with diabetes type 1 (DM1). Interdependencies between the course of diabetes in mothers and fetal-perinatal complications and neurological state of the progeny were also analysed. 35 children of mothers with DM1 and 109 in control group underwent neurological examinations at the age of 3, 6, 9, 12 and 18 months.


RESULTS
In the group of children of DM1 mothers four had symptoms of CNS damage such as cerebral palsy or psychomotor delay. In the remaining 9 children so-called "soft" neurological signs or minor neurological dysfunction were found. In control group 1 had a light form of cerebral palsy and 3 had symptoms of minor neurological dysfunction. The dependencies of frequency and gravity of neurological disorders in children on diabetes metabolic control and complications and hypoxemic-ischemic states, prematurity, macrosomia and hypoglycemia in newborns was observed.


CONCLUSIONS
The symptoms of CNS dysfunctions are more frequent and more serious in children of DM1 mothers than in control group.
Ircha
G
G
Kliniki Neurologii Instytutu CZMP w Lodzi.
Zawodniak-Szałapska
M
M
Cypryk
K
K
Wilczyński
J
J
D000293:Adolescent; D000328:Adult; D002493:Central Nervous System Diseases / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis*; D003922:Diabetes Mellitus, Type 1; D005260:Female; D006801:Humans; D009460:Neurologic Examination; D011247:Pregnancy; D011248:Pregnancy Complications; D011446:Prospective Studies