Activation of hematoporphyrin in alternating magnetic field: possible implications for cancer treatment.
A new mechanism of cell damage by alternating magnetic field with hematoporphyrin is described. C6 glioblastoma cell suspensions were exposed to an alternating magnetic field with frequency 180 kHz up to 60 min in the presence of hematoporphyrin in H2O and in D2O. The results presented suggest that an alternating magnetic field is able to activate hematoporphyrin, and this method may be a basis for cancer treatment.
Babincová
M
M
Department of Biophysics and Chemical Physics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk
Sourivong
P
P
Leszczynska
D
D
Babinec
P
P
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D017666:Deuterium Oxide; D004574:Electromagnetic Fields; D005909:Glioblastoma; D006415:Hematoporphyrins / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects*; D010778:Photochemotherapy; D051381:Rats; D014407:Tumor Cells, Cultured
D006415:Hematoporphyrins; D017666:Deuterium Oxide