title: [The effect of large dose prednisone therapy on immunological markers in multiple sclerosis].
abstract: The effect of large-dose prednisone therapy (3960 mg over 56 days) on humoral immunological markers and MRI pattern was studied in 25 patients with clinically definite multiple sclerosis. There was a decrease in levels of some studied markers (TNF in CSF, MBP level, IgG index, kappa chains in urine and kappa/creatinine ratio) after the treatment, but the differences reached statistical significance in some groups only. The decrease of total lesion area in MRI was not statistically significant. The obtained results proved clearly, that the above mentioned immunological markers might be helpful for monitoring of therapy in MS patients.
authors.affiliation: Zespołu Neuroimmunologicznego Centrum Medycyny Doświadczalnej i Klinicznej PAN w Poznaniu.
authors.forename: M
authors.initials: M
authors.lastname: Wender
authors.forename: J
authors.initials: J
authors.lastname: Losy
authors.forename: G
authors.initials: G
authors.lastname: Michałowska-Wender
authors.forename: W
authors.initials: W
authors.lastname: Kozubski
authors.forename: P
authors.initials: P
authors.lastname: Sosnowski
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D015415:Biomarkers; D001921:Brain / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D007145:Immunoglobulin kappa-Chains / Q000652:urine; D008279:Magnetic Resonance Imaging; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology; D011241:Prednisone / Q000008:administration & dosage*; D015375:Receptors, Interleukin-2 / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D015415:Biomarkers; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D004676:Myelin Basic Protein; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D011241:Prednisone