Application of comparative molecular field analysis to dopamine D2 partial agonists.
Comparative molecular field analysis (CoMFA) has been applied to novel D2 partial agonists. Due to the predictability of the CoMFA model across different series of D2 partial agonists, we believe these compounds are binding to the D2 agonist receptor in the conformation and alignment described herein.
McGaughey
G B
GB
Structural Biology and Global Chemical Sciences, Wyeth-Ayerst Research Laboratories, Princeton, NJ 08543-8000, USA.
Mewshaw
R E
RE
D008958:Models, Molecular; D017448:Receptors, Dopamine D2 / Q000819:agonists*; D013329:Structure-Activity Relationship
D017448:Receptors, Dopamine D2