title: Bone reactions to anorganic bovine bone (Bio-Oss) used in sinus augmentation procedures: a histologic long-term report of 20 cases in humans.
abstract: Many materials are used for sinus augmentation procedures. Anorganic bovine bone (Bio-Oss) has been reported to be osteoconductive, and no inflammatory responses have been observed with the use of this biomaterial. One of the main questions pertaining to Bio-Oss concerns its biodegradation and substitution by host bone. Some investigators have observed rapid replacement by host bone, while other researchers observed slow resorptive activity or no resorption at all. The aim of the present study was to conduct a long-term histologic analysis of retrieved specimens in humans where Bio-Oss was used in sinus augmentation procedures. Specimens were retrieved from 20 patients after varying periods from 6 months to 4 years and were processed to obtain thin ground sections. Bio-Oss particles were surrounded for the most part by mature, compact bone. In some Haversian canals it was possible to observe small capillaries, mesenchymal cells, and osteoblasts in conjunction with new bone. No gaps were present at the interface between the Bio-Oss particles and newly formed bone. In specimens retrieved after 18 months and 4 years, it was also possible to observe the presence of osteoclasts in the process of resorbing the Bio-Oss particles and neighboring newly formed bone. Bio-Oss appears to be highly biocompatible and osteoconductive, is slowly resorbed in humans, and can be used with success as a bone substitute in maxillary sinus augmentation procedures.
authors.affiliation: Dental School, University of Chieti, Italy. apiattelli@unich.it
authors.forename: M
authors.initials: M
authors.lastname: Piattelli
authors.forename: G A
authors.initials: GA
authors.lastname: Favero
authors.forename: A
authors.initials: A
authors.lastname: Scarano
authors.forename: G
authors.initials: G
authors.lastname: Orsini
authors.forename: A
authors.initials: A
authors.lastname: Piattelli
mesh_terms: D020341:Absorbable Implants; D016301:Alveolar Bone Loss / Q000601:surgery; D000818:Animals; D001673:Biodegradation, Environmental; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D002417:Cattle; D006801:Humans; D008443:Maxillary Sinus / Q000601:surgery*; D008903:Minerals / Q000494:pharmacology*; D013516:Oral Surgical Procedures, Preprosthetic
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals