title: Rationale and design of the magnesium in coronaries (MAGIC) study: A clinical trial to reevaluate the efficacy of early administration of magnesium in acute myocardial infarction.
abstract: BACKGROUND
  Mortality rate from ST-elevation myocardial infarction remains high in elderly patients and in patients who are not eligible for reperfusion therapy. Intravenous magnesium is a promising adjunctive treatment that may reduce reperfusion injury. Several earlier trials demonstrated a mortality rate reduction with magnesium treatment, but one large trial found no benefit.
  
  
  METHODS
  Magnesium in Coronaries (MAGIC) is a large, simple trial designed to maximize the potential treatment effect of magnesium. 10, 400 high-risk patients with ST-elevation myocardial infarction will be randomly assigned to early treatment with intravenous magnesium sulfate or matching placebo. The primary end point is death at 30 days. Information on the need for treatment of shock and sustained ventricular arrhythmias will be collected to investigate the mechanisms by which magnesium might exert a beneficial effect.
  
  
  CONCLUSIONS
  If magnesium proves beneficial, its use will provide a simple, cost-effective means to improve survival in this large patient population.
authors.affiliation: New England Research Institutes, Inc., Clincal Trial Center, Watertown, MA 02472, USA.
mesh_terms: D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D004311:Double-Blind Method; D004562:Electrocardiography; D006801:Humans; D007275:Injections, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D002121:Calcium Channel Blockers; D008278:Magnesium Sulfate