[Neonatal alloimmune neutropenias. Importance of treatment with granulocyte colony-stimulating factor (G-CSF). Report of 2 new cases].
Alloimmune neonatal neutropenia is a rare event. Usually asymptomatic, it may however in some cases result in a severe sepsis. Treatment with recombinant granulocyte colony-stimulating factor (G-CSF) has been recently proposed.


METHODS
We report two new cases in infected newborns of a successful treatment of alloimmune neonatal neutropenia with G-CSF, resulting in complete neutrophil recovery in less than 72 hours. Moreover, the treatment was well tolerated.


CONCLUSIONS
The analysis of these two cases and of those previously reported indicates that G-CSF represents the first-choice treatment in this affection when infectious signs are present in the neonate.
Bédu
A
A
Service de néonatologie, Hôpital Robert-Debré, Paris, France.
Rohrlich
P
P
Farnoux
C
C
Duval
M
M
Fenneteau
O
O
Boissinot
C
C
Pinquier
D
D
Cartron
J
J
Vilmer
E
E
Aujard
Y
Y
D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology; D008297:Male; D009503:Neutropenia / Q000276:immunology* / Q000628:therapy*; D013997:Time Factors
D007519:Isoantigens; D016179:Granulocyte Colony-Stimulating Factor