title: Tetrasomy 8 evolving into a segmental triplication 8q in a case of acute monocytic leukemia.
abstract: We report a case of AML-M5 with tetrasomy 8 that evolved within a 7-month period to a segmental triplication 8q. Other numerical abnormalities in the initial diagnosis were not found at the relapse; however, a chromosome 1 structural abnormality was maintained, proving the clonal evolution from tetrasomy 8 to a segmental triplication of the long arm of 8. This strongly suggests that there is a functional and selective advantage for duplications and triplications of 8q in these patients.
authors.affiliation: Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Qumsiyeh
authors.forename: C
authors.initials: C
authors.lastname: Cheng
authors.forename: J
authors.initials: J
authors.lastname: Eyre
authors.forename: K P
authors.initials: KP
authors.lastname: Mann
authors.forename: X X
authors.initials: XX
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000782:Aneuploidy; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male