title: New triterpenoids with antibacterial activity from Zizyphus joazeiro.
abstract: The stem bark of the Brazilian medicinal plant Zizyphus joazeiro C. Mart. was phytochemically investigated. Three known compounds (betulinic, ursolic and alphitolic acid) and three new derivatives of betulinic acid, 7 beta-(4-hydroxybenzoyloxy)-betulinic acid, 7 beta-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid and 27-(4-hydroxy-3'-methoxybenzoyloxy)-betulinic acid which showed a considerable activity against Gram-positive bacteria were isolated from the dichloromethane extract. The structures were established on the basis of NMR spectroscopy and mass spectrometry.
authors.affiliation: Department of Pharmacy, Swiss Federal Institute of Technology (ETH) Zurich, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Schühly
authors.forename: J
authors.initials: J
authors.lastname: Heilmann
authors.forename: I
authors.initials: I
authors.lastname: Calis
authors.forename: O
authors.initials: O
authors.lastname: Sticher
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014315:Triterpenes