Liver granulomatosis is not an exceptional cause of hypercalcemia with hypoparathyroidism in dialysis patients.
In 4 of our patients on chronic dialysis, we were intrigued by the association of hypercalcemia +/- hyperphosphatemia and normal intact PTH, with anicteric cholestasis without cytolysis. This picture occurred in 2 patients after they resumed dialysis because of a transplant rejection and in a third one after discontinuation of corticosteroids, prescribed for an idiopathic thrombocytopenia. No patient was under calcitriol, CaCO3 therapy, and their hypercalcemia persisted on a low calcium dialyzate (1.25 mmol/l). Obvious etiologies of hypercalcemia were not found: vitamin D or A intoxication, hyperparathyroidism, aluminum intoxication, hemopathy, HIV infection. The hypothesis of a granulomatous disease was made and a liver biopsy was performed showing granulomas with giant epitheloid cells. In one case foreign material (silicon ?) was present in the macrophages. Extensive investigations for sarcoidosis, tuberculosis and mycosis were negative. In 2 cases the so-called "dialysis" granulomatosis actually occurred in transplanted patients, suggesting the role of a transplantation related factor (toxic or virus). In the last case HCV seroconversion was present. In the 4 cases, corticotherapy led to the disappearance of hypercalcemia and to an increase of PTH. Our patients had the biological pattern of low bone turnover disease (hypercalcemia and normal intact PTH) and bone biopsy performed in 2 showed osteomalacia or ABD without aluminum. The association of this pattern with cholestasis should evoke liver granulomatosis, which should be confirmed by a liver biopsy and lead to a treatment by corticosteroids. The masking effect of previous corticoid therapy for transplantation should be pointed out. In 2 cases serial monitoring of plasma calcitriol showed a relation between decreasing high normal calcitriol with prednisone and normalization of calcemia, suggesting the role of inappropriate synthesis of calcitriol by the granuloma. In conclusion, liver granulomatosis should be looked for in dialysis patients on the association of unexplained hypercalcemia and normal PTH with anicteric cholestasis, and confirmed by a liver biopsy. Although still of unknown etiology, its evolution is favourable under corticotherapy.
Hardy
P
P
Department of Nephrology, Internal Medicine, CHU Amiens, France.
Morinière
P H
PH
Tribout
B
B
Hamdini
N
N
Marié
A
A
Bouffandeau
B
B
Pruna
A
A
Fournier
A
A
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000097:blood; D002779:Cholestasis / Q000150:complications; D005260:Female; D006099:Granuloma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology*; D007011:Hypoparathyroidism / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011241:Prednisone / Q000627:therapeutic use; D006435:Renal Dialysis / Q000009:adverse effects
D010281:Parathyroid Hormone; D002117:Calcitriol; D011241:Prednisone