In search of new chemical entities with spermicidal and anti-HIV activities.
Several compounds belonging to 2-isoxazolines (4,5a-c), isoxazoles (3,6a-c) and 1-amino-1-cycloalkyl-2-substituted phenyl ethanes (16-18,a-e) have been synthesised and found to possess spermicidal activity. Out of these a couple of compounds (5a and 6a) exhibit anti-HIV activity.
Srivastava
S
S
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India.
Bajpai
L K
LK
Batra
S
S
Bhaduri
A P
AP
Maikhuri
J P
JP
Gupta
G
G
Dhar
J D
JD
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D013089:Spermatocidal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D019380:Anti-HIV Agents; D013089:Spermatocidal Agents