title: [Influence of pre-conception pregnancy planning in women with diabetes mellitus I on the number of spontaneous abortions and major congenital malformations in their children].
abstract: OBJECTIVE
  The study assesses the relationship between pre-conception pregnancy planning and number of spontaneous abortions and major congenital malformations in their children.
  
  
  METHODS
  138 pregnancies in women with type 1 diabetes without complications or only with simple retinopathy (White B, C, D) were analyzed. Women were treated in the Outpatient Family Planning Center in Warsaw between 1988 and 1998. Thirty women were planning the pregnancy prior to conception, 108 registered already when pregnant. The groups compared did not differ statistically in age, duration of diabetes or diabetic angiopathy. Mean values of HbA1C in consecutive trimesters were: 6.40%, 5.84%, 5.67% in the group of patients planning the pregnancy and 6.99%, 6.29%, 6.15% in the non-planning group. The differences were statistically significant (p < 0.05, p < 0.05, p < 0.01).
  
  
  RESULTS
  In the pre-conception group there were no spontaneous abortions and no and major congenital malformations. Mean value of HbA1C in early pregnancy was significantly higher in women with spontaneous abortions than in the remaining women in the non-planning group (respectively 7.9% and 6.9%). Also, mean value of HbA1C in early pregnancy was significantly higher in women who gave birth to children with major congenital malformations than in women had healthy children (respectively 8.23% and 6.81%, p < 0.05).
  
  
  CONCLUSIONS
  Pre-conception pregnancy planning improves metabolic control during pregnancy and decreases the rate of spontaneous abortions and major congenital malformations.
authors.affiliation: Katedry i Kliniki Chorób Wewnetrznych i Diabetologii AM w Warszawie.
authors.forename: I
authors.initials: I
authors.lastname: Raźna
authors.forename: A
authors.initials: A
authors.lastname: Czech
authors.forename: J
authors.initials: J
authors.lastname: Tatoń
authors.forename: K
authors.initials: K
authors.lastname: Jezierska-Kasprzyk
authors.forename: M
authors.initials: M
authors.lastname: Mironiuk
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D000013:Congenital Abnormalities / Q000175:diagnosis*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D005193:Family Planning Services; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy