title: Malignant transformation in pleomorphic xanthoastrocytoma--a report of two cases.
abstract: Pleomorphic xanthoastrocytomas (PXA) with malignant transformation are reported in two adult men with a long history of seizures, recent onset of neurological symptoms and superficially located, temporal lobe lesions. Although PXA is generally described as having relatively benign behaviour, this report adds two further cases of malignant transformation to the literature.
authors.affiliation: Department of Neuropathology, Leeds General Infirmary, UK. arunac@pathology.leeds.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Chakrabarty
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: L R
authors.initials: LR
authors.lastname: Bridges
authors.forename: A J
authors.initials: AJ
authors.lastname: Franks
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000150:complications / Q000473:pathology*; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000150:complications