Regulation of mesangial cell proliferation.
Regardless of the source of injury, an imbalance in the control of mesangial cell proliferation appears to play a direct role in the degree of progressive renal injury and glomerulosclerosis. Some of the regulatory mechanisms include specific soluble or non-soluble extracellular factors and a complex array of receptor-mediated signals that control the progression of the cell cycle or cell death. Understanding these regulatory processes could lead to novel therapeutic strategies to alleviate or arrest proliferative glomerular disease.
Schöcklmann
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Medizinische Klinik IV, Universität Erlangen-Nürnberg, Erlangen, Germany.
Lang
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Sterzel
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D000328:Adult; D000818:Animals; D002455:Cell Division / Q000502:physiology; D005920:Glomerular Mesangium / Q000473:pathology*; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D006801:Humans