[Role of abdominal obesity in pathogenesis of insulin resistance syndrome].
OBJECTIVE
To study relationships between pathogenesis of obesity, essential hypertension (EH), hyperlipidemia, ischemic heart disease (IHD) and diabetes mellitus (DM) type II.


METHODS
Glucose and insulin levels in blood, serum lipids were measured, glucose and prednisolone glucose tolerance tests were made in 75 patients with abdominal and 75 patients with gluteofemoral obesity.


RESULTS
The results of the study of 75, 75, 763 and 340 patients with abdominal, gluteofemoral obesity, IHD and DM type II, respectively, show that pathogenesis of abdominal obesity, essential hypertension, hyperlipidemia, IHD, abnormal glucose tolerance and diabetes mellitus type II has common features: relative hypercorticoidism, insulin resistance and hyperinsulinemia.


CONCLUSIONS
Abdominal obesity is the earliest symptom in composition of metabolic cardiovascular syndrome. Prevention or early treatment of this obesity can prevent or delay onset of diseases associated with this syndrome.
Almazov
V A
VA
Blagosklonnaia
Ia V
IaV
Shliakhto
E V
EV
Krasil'nikova
E I
EI
D001067:Appetite Depressants / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D018752:Diet, Fat-Restricted; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D006973:Hypertension / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control; D009765:Obesity / Q000097:blood / Q000145:classification / Q000150:complications* / Q000628:therapy; D012307:Risk Factors; D013577:Syndrome
D001067:Appetite Depressants; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids