[Effect of modification of been venom components on its hemolytic activity and ability to decrease the volume of the human erythrocyte].
The crude bee venom was modified by different chemical substances. The inverse correlation was established between increase of the hemolytic activity and decrease of the contractive one under modification of the bee venom by NaOH and KOH. The negligible decrease of the contractive activity occurs in the acid conditions (pH 1,0), while hemolytic one is stationary. Dithiothreitol, mercaptoethanol, urea and high temperature (60-90 degrees C) did not affect activity of the bee venom.
Parchenko
T A
TA
Kharkiv State University.
Rudenko
S V
SV
D001514:Bee Venoms / Q000737:chemistry / Q000494:pharmacology*; D004229:Dithiothreitol / Q000494:pharmacology; D004911:Erythrocyte Volume / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects*; D006358:Hot Temperature; D006801:Humans; D006878:Hydroxides / Q000737:chemistry; D066298:In Vitro Techniques; D008623:Mercaptoethanol / Q000494:pharmacology; D017680:Potassium Compounds / Q000737:chemistry; D012972:Sodium Hydroxide / Q000737:chemistry
D001514:Bee Venoms; D006878:Hydroxides; D017680:Potassium Compounds; D012972:Sodium Hydroxide; D008623:Mercaptoethanol; D004229:Dithiothreitol; C029943:potassium hydroxide