Lung transplantation for patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome.
Sauropus androgymus (SA), a vegetable of the Euphorbiaceae family, is a common food source in Malaysia. In Taiwan, over 30 patients have developed progressive respiratory failure after consuming the extract from raw SA leaves as a means of losing weight. Symptoms consistent with a severe obstructive ventilatory defect progressed, despite cessation of SA intake and treatment with bronchodilators, corticosteroids, cytotoxic agents and plasmaphresis. Five patients with end-stage Sauropus androgynus-induced bronchiolitis obliterans (SABO) syndrome underwent lung transplantation. There was no early mortality. One patient died of post-transplant lymphoproliferative disorder and another patient died of bronchial stenosis with infection, 5 and 3.5 months, respectively, post-transplantation. The remaining 3 patients have been followed from 29 to 34 months, with improved general condition and pulmonary function. Perfusion/ventilation scans revealed that these improvements were exclusively attributed to the functional grafts. We believe that lung transplantation is the only effective modality of treatment for patients with end-stage SABO syndrome.
Luh
S P
SP
Department of Surgery, National Taiwan University Hospital, Taipei, Republic of China.
Lee
Y C
YC
Chang
Y L
YL
Wu
H D
HD
Kuo
S H
SH
Chu
S H
SH
D000328:Adult; D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008875:Middle Aged; D014675:Vegetables / Q000009:adverse effects*