title: A cyclodextrin dimer with a photocleavable linker as a possible carrier for the photosensitizer in photodynamic tumor therapy.
abstract: A cyclodextrin dimer has been synthesized with two beta-cyclodextrins linked by a flexible chain containing a carbon-carbon double bond. This dimer binds and solubilizes a phthalocyanine-based photosensitizer that generates singlet oxygen on irradiation. When the complex is irradiated, the singlet oxygen cleaves the carbon-carbon link, and the cyclodextrins are released, liberating the photosensitizer into the light path. Ideas about how this phenomenon could be used to make photodynamic tumor therapy into a more selective process are described.
authors.affiliation: Department of Chemistry, Columbia University, New York, NY 10027, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ruebner
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Leung
authors.forename: R
authors.initials: R
authors.lastname: Breslow
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D019281:Dimerization; D004337:Drug Carriers / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; C013647:phthalocyanine