Resin effects in solid phase S(n)Ar and S(n)2 macrocyclizations.
Seven different supports were compared in solid-phase S(N)Ar and S(N)2 macrocyclization reactions. Product purities were assayed for a relatively facile ring-closure process to give products 1 and 3. Some less-facile ring-closure reactions give the undesired dimeric macrocyclization by-products 2; some of these more-demanding ring closures were also examined. Finally, experiments were performed to gauge the rate of cyclizations on different resins, and some qualitative data were obtained for this.
Feng
Y
Y
Texas A & M University, Chemistry Department, P.O. Box 30012, College Station, Texas 77842, USA.
Burgess
K
K
D019281:Dimerization; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D011137:Polystyrenes; D012116:Resins, Plant
D006844:Hydrocarbons, Cyclic; D007202:Indicators and Reagents; D011137:Polystyrenes; D012116:Resins, Plant