Evaluation of DNA content and proliferative activity in prediction of short-term relapses in mammary carcinoma: a prospective study.
DNA content according to six various ploidy classes was analysed by flow cytometry on fresh tumor tissue in 701 unselected, consecutive breast cancers. Age, menopausal status, tumor size, histology and in particular nodal status were also taken into consideration. Diploid and nondiploid mammary carcinomas differed significantly in values of proliferative indicators. In node positive patients nondiploid tumors were more frequent. In node negative and node positive breast cancer patients tumor grade strongly influenced disease free survival and in the last group hypertriploidy (1.6 < DI < or = 1.8) was also an independent prognostic factor. The combination of tumor grade and hypertriploidy permitted differentiation of three groups of node positive patients, differing in the risk of relapses.
Lackowska
B
B
Department of Pathology, Oncology Center, Kraków.
Niezabitowski
A
A
Ryś
J
J
Skołyszewski
J
J
Stelmach
A
A
Sokołowski
A
A
Gruchała
A
A
Jaszcz-Gruchała
A
A
Markiewicz
D
D
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002455:Cell Division; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D016195:G2 Phase; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology; D011446:Prospective Studies; D016196:S Phase; D016019:Survival Analysis
D004273:DNA, Neoplasm