Efficacy of five days' barbiturate anesthesia in the treatment of intractable epilepsies in children.
OBJECTIVE
To analyze the efficacy of barbiturate anesthesia in the treatment of intractable epilepsies in childhood.


METHODS
Anesthesia for 4-5 days with thiopentone sodium was used to treat children with intractable epilepsy in the Department of Pediatrics, Oulu, Finland, from November 1980 through December 1995. The number of epileptic seizures, the number and dosage of antiepileptic drugs (AEDs), and psychomotor development before and after anesthesia were compared.


RESULTS
Fifty-four children with intractable epilepsy were treated with barbiturate anesthesia. Twenty-four children had infantile spasms; 22, Lennox-Gastaut syndrome; seven, complex partial epilepsy; and one, myoclonic epilepsy. Twenty-four (44.4%) children had complications during the anesthesia. The seizures recurred in 53 of the 54 patients in a median time of 12 days after the anesthesia. In 42 (78%) children, the seizure frequency returned to a level equal to or higher than that before the anesthesia in a median time of 211 days. The number of AEDs was significantly greater after than before the anesthesia (6.33 vs. 4.8; p < 0.001). Seventeen (32.5%) children were treated surgically after the anesthesia.


CONCLUSIONS
Although the seizures are eliminated or the seizure frequency decreases for a short period after the barbiturate anesthesia, the anesthesia does not change the long-term outcome and is therefore inefficient in the treatment of childhood intractable epilepsies.
Rantala
H
H
Department of Pediatrics, University of Oulu, Finland. Heikki.Rantala@oulu.fi
Saukkonen
A L
AL
Remes
M
M
Uhari
M
M
D000293:Adolescent; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013874:Thiopental / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D018686:Anesthetics, Intravenous; D013874:Thiopental