Loss of atheroprotective effect of estradiol in immunodeficient mice.
Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.
Elhage
R
R
INSERM U397, Institut L. Bugnard, Toulouse, France.
Clamens
S
S
Reardon-Alulis
C
C
Getz
G S
GS
Fievet
C
C
Maret
A
A
Arnal
J F
JF
Bayard
F
F
D000818:Animals; D001011:Aorta / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics* / Q000276:immunology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D019895:Transposases / Q000235:genetics / Q000378:metabolism
D001057:Apolipoproteins E; D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2; D004958:Estradiol; D019895:Transposases