Bioactive indole alkaloids from the bark of Uncaria guianensis.
Bioassay-guided fractionation of the EtOH extract of the bark of Uncaria guianensis (Aubl.) Gmel (Rubiaceae) using a yeast-based assay for DNA-damaging agents has furnished the two weakly but selectively active indole alkaloids uncarine C (1) and uncarine E (2) as the major bioactive constituents in this assay.
Lee
K K
KK
Zhou
B N
BN
Kingston
D G
DG
Vaisberg
A J
AJ
Hammond
G B
GB
D016475:3T3 Cells; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D019666:Rubiaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D007211:Indoles