Localized bullous pemphigoid in a patient with B-cell lymphoma.
Bullous pemphigoid (BP) is an immunobullous disease characterized by circulating IgG antibodies directed towards cutaneous basement zone antigens. We report the case of a patient who had BP localized to a stoma site. At initial examination, a nodule was noted on the temple, which proved to be a large cell lymphoma, B-cell phenotype. On Western immunoblot, the patient's serum showed circulating IgG antibodies reactive with the 230 kDa BP antigen and the 97 kDa linear IgA bullous dermatosis antigen. The co-incident onset of the two diseases suggest that this may represent a case of paraneoplastic BP.
Egan
C A
CA
Department of Dermatology, University of Utah School of Medicine, Section of Dermatology, Salt Lake City Veterans Affairs Medical Center, USA.
Florell
S R
SR
Zone
J J
JJ
D000368:Aged; D015153:Blotting, Western; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000276:immunology; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000276:immunology; D010391:Pemphigoid, Bullous / Q000209:etiology* / Q000276:immunology
D007074:Immunoglobulin G