Synthesis and hybridization properties of oligonucleotides containing 6-membered azasugar nucleotides.
A modified nucleoside was synthesized with adenine and a 6-membered azasugar, and it was converted to the phosphoramidite which was used for the incorporation into oligonucleotides. The hybridization properties of the modified oligonucleotides with DNA and RNA were studied.
Jung
K E
KE
AgroPharma Research Institute, Dongbu Research Council, Taejon, Korea.
Kim
K
K
Yang
M
M
Lee
K
K
Lim
H
H
D001372:Aza Compounds / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004591:Electrophoresis, Polyacrylamide Gel; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013873:Thionucleotides / Q000737:chemistry
D001372:Aza Compounds; D002241:Carbohydrates; D009841:Oligonucleotides; D013873:Thionucleotides