title: [Immunological markers of disease activity in the course of 2-CDA treatment of multiple sclerosis].
abstract: 52 clinically definite multiple sclerosis (MS) patients were treated with subcutaneous injection of 5 mg 2-CDA in 5 consecutive days. The injection courses were repeated 6 times in one month interval. The MRI pattern and immunological markers were studied in serum and CSF before and after 6 months of treatment. The obtained results suggest that treatment with 2-CDA has not any significant effect on humoral immunological events in multiple sclerosis, what is in contrast to some normalization of cellular immunopathological processes.
authors.affiliation: Zespołu Neuroimmunologicznego Centrum Medycyny Doświadczalnej i Klinicznej PAN w Poznaniu.
authors.forename: G
authors.initials: G
authors.lastname: Michałowska-Wender
authors.forename: E
authors.initials: E
authors.lastname: Tokarz-Kupczyk
authors.forename: J
authors.initials: J
authors.lastname: Losy
authors.forename: M
authors.initials: M
authors.lastname: Sniatała-Kamasa
authors.forename: M
authors.initials: M
authors.lastname: Wender
mesh_terms: D015762:2-Chloroadenosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000627:therapeutic use; D000917:Antibody Formation; D000918:Antibody Specificity; D015703:Antigens, CD / Q000097:blood / Q000276:immunology; D000964:Antimetabolites, Antineoplastic / Q000276:immunology* / Q000627:therapeutic use*; D015415:Biomarkers; D003839:Deoxyadenosines / Q000276:immunology* / Q000627:therapeutic use*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology*; D010641:Phenotype; D015375:Receptors, Interleukin-2 / Q000097:blood / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000964:Antimetabolites, Antineoplastic; D015415:Biomarkers; D003839:Deoxyadenosines; D007136:Immunoglobulins; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D015762:2-Chloroadenosine; C055994:2-chloro-3'-deoxyadenosine