title: Procedural and late outcomes following MULTI-LINK DUET coronary stent deployment.
abstract: The MULTI-LINK DUET is the next generation MULTI-LINK stent with modified strut geometry. Safety and efficacy of the MULTI-LINK DUET were evaluated in a prospective multicenter registry and were compared with prior MULTI-LINK stent experience from the ASCENT randomized trial. A total of 270 patients received 302 MULTI-LINK DUET stents and were evaluated using a composite primary end point of major cardiac events (death, Q-wave and non-Q-wave myocardial infarction, and requirement for coronary revascularization) attributable to the target stenosis cumulative to 30 days following enrollment. Quantitative coronary angiography was performed at a mean follow-up of 6 +/- 2 (+/-SD) months. No difference in primary end point or in angiographic restenosis to 6 months was observed between MULTI-LINK DUET and MULTI-LINK experiences. The MULTI-LINK DUET demonstrated improved device and procedural success, less postprocedural in-stent stenosis, larger postprocedural minimal lumen diameter, and fewer postprocedural marginal dissections compared with the MULTI-LINK stent. Multivariate regression modeling identified stent length, diabetes mellitus, poststent minimal lumen diameter, lesion eccentricity, and current smoking as independent predictors of in-stent restenosis. Thus, the MULTI-LINK DUET Registry demonstrates enhanced procedural performance with clinical and angiographic outcomes similar to those previously observed for the MULTI-LINK stent in the ASCENT randomized trial.
authors.affiliation: Linder Research Center, Cincinnati, Ohio 45219, USA. lindner@healthhall.com
authors.forename: D J
authors.initials: DJ
authors.lastname: Kereiakes
authors.forename: M
authors.initials: M
authors.lastname: Midei
authors.forename: J
authors.initials: J
authors.lastname: Hermiller
authors.forename: C
authors.initials: C
authors.lastname: O'Shaughnessy
authors.forename: R
authors.initials: R
authors.lastname: Schlofmitz
authors.forename: S
authors.initials: S
authors.lastname: Yakubov
authors.forename: S
authors.initials: S
authors.lastname: Fink
authors.forename: F
authors.initials: F
authors.lastname: Hu
authors.forename: N
authors.initials: N
authors.lastname: Nishimura
authors.forename: M
authors.initials: M
authors.lastname: Sievers
authors.forename: M E
authors.initials: ME
authors.lastname: Valentine
authors.forename: T
authors.initials: T
authors.lastname: Broderick
authors.forename: A
authors.initials: A
authors.lastname: Lansky
authors.forename: J
authors.initials: J
authors.lastname: Moses
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D002423:Cause of Death; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D019544:Equipment Failure Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality; D011446:Prospective Studies; D011474:Prosthesis Design; D011859:Radiography; D015607:Stents; D015996:Survival Rate; D016896:Treatment Outcome