Tbx5 and the retinotectum projection.
Dorsal and ventral aspects of the eye are distinct from the early stages of development. The developing eye cup grows dorsally, and the choroidal fissure is formed on its ventral side. Retinal axons from the dorsal and ventral retina project to the ventral and dorsal tectum, respectively. Misexpression of the Tbx5 gene induced dorsalization of the ventral side of the eye and altered projections of retinal ganglion cell axons. Thus, Tbx5 is involved in eye morphogenesis and is a topographic determinant of the visual projections between retina and tectum.
Koshiba-Takeuchi
K
K
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, Japan 630-0101.
Takeuchi
J K
JK
Matsumoto
K
K
Momose
T
T
Uno
K
K
Hoepker
V
V
Ogura
K
K
Takahashi
N
N
Nakamura
H
H
Yasuda
K
K
Ogura
T
T
D000818:Animals; D030161:Avian Proteins; D001369:Axons / Q000648:ultrastructure*; D019521:Body Patterning; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000502:physiology; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000235:genetics; D018274:Electroporation; D036387:Ephrin-B1; D036388:Ephrin-B2; D005123:Eye / Q000196:embryology*; D015870:Gene Expression; D018398:Homeodomain Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D009024:Morphogenesis; D051762:PAX2 Transcription Factor; D010857:Pigment Epithelium of Eye / Q000196:embryology / Q000378:metabolism; D012160:Retina / Q000196:embryology* / Q000378:metabolism; D012165:Retinal Ganglion Cells / Q000648:ultrastructure; D013477:Superior Colliculi / Q000196:embryology*; D020825:T-Box Domain Proteins / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics; D014162:Transfection; D019076:Transgenes
D030161:Avian Proteins; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; D004268:DNA-Binding Proteins; D036387:Ephrin-B1; D036388:Ephrin-B2; D018398:Homeodomain Proteins; D008565:Membrane Proteins; D051762:PAX2 Transcription Factor; D020825:T-Box Domain Proteins; C103172:T-box transcription factor 5; D014157:Transcription Factors; C402296:Vax protein, chicken