[Neck lymph node metastases of unknown origin: nasopharyngeal origin and EBV (Epstein-Barr virus)].
We present a retrospective series of 16 cases of undifferentiated squamous carcinoma in cervical metastatic nodes of unknown primary. We review their clinical and radiological evaluation in search of a possible primary tumor, their response to treatment and the eventual development of a primary tumor. Furthermore, we study the presence of Epstein-Barr virus in the metastases as a predictor of their nasopharyngeal origin, in relation to the finding of primary lesions in the nasopharynx during further follow-up of the cases.
Plaza
G
G
Fundación Hospital Alcorcón, Madrid, España. gplaza@fhalcorcon.es
Santón
A
A
Fogué
L
L
Bellas
C
C
Martínez Vidal
A
A
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary* / Q000821:virology*; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D004854:Herpesvirus 4, Human; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000821:virology*; D009333:Neck; D009382:Neoplasms, Unknown Primary / Q000473:pathology; D012189:Retrospective Studies; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology