Anti-allergic components from the peels of Citrus unshiu.
In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, polymethoxyflavones, 3',4',5,6,7,8-hexamethoxyflavone (1), 5-hydroxy-3',4',6,7,8-pentamethoxyflavone (II) and 3',4',5,7,8,-pentamethoxyflavone (III) have been isolated from the immature peels of Citrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds I and II inhibited dose-dependently histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.
Kim
D K
DK
College of Pharmacy, Woosuk University, Samrye, Korea. dkkim@core.woosuk.ac.kr
Lee
K T
KT
Eun
J S
JS
Zee
O P
OP
Lim
J P
JP
Eum
S S
SS
Kim
S H
SH
Shin
T Y
TY
D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D007723:Korea; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared
D018926:Anti-Allergic Agents; D010936:Plant Extracts