Scopolamine augments transient auditory 40-hz magnetic response in humans.
The influence of neocortical muscarinic transmission on auditory-evoked 40-Hz magnetic response was studied in 13 healthy subjects in a double-blind randomized cross-over design. Either a centrally (scopolamine hydrobromide, 0.3 mg, i.v.) or a peripherally (glycopyrrolate, 0.2 mg, i.v.) acting antagonist of muscarinic transmission was administered during two sessions of magnetoencephalographic recording of 40-Hz response elicited by monaural tones. Scopolamine significantly (P < 0.01) augmented the 40-Hz magnetic response over the hemispheres ipsi- and contralateral to the ear stimulated. This finding suggests muscarinic modulation of the auditory evoked transient 40-Hz response.
Ahveninen
J
J
Department of Psychology, University of Helsinki, Finland. jyrki.ahveninen@helsinki.fi
Tiitinen
H
H
Hirvonen
J
J
Pekkonen
E
E
Huttunen
J
J
Kaakkola
S
S
Jääskeläinen
I P
IP
D000328:Adult; D000704:Analysis of Variance; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology*; D006801:Humans; D015225:Magnetoencephalography / Q000187:drug effects*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology*
D018727:Muscarinic Antagonists; D012601:Scopolamine; D006024:Glycopyrrolate