title: Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream.
abstract: A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co-applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.
authors.affiliation: Department of Dermatology, Aberdeen Royal Infirmary, Foresthill, UK. a.d.ormerod@abdn.ac.uk
authors.forename: A D
authors.initials: AD
authors.lastname: Ormerod
authors.forename: M I
authors.initials: MI
authors.lastname: White
authors.forename: S A
authors.initials: SA
authors.lastname: Shah
authors.forename: N
authors.initials: N
authors.lastname: Benjamin
mesh_terms: D000279:Administration, Cutaneous; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008976:Molluscum Contagiosum / Q000188:drug therapy*; D020030:Nitric Oxide Donors / Q000627:therapeutic use*; D020156:Salicylic Acid / Q000627:therapeutic use; D012977:Sodium Nitrite / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations; D020030:Nitric Oxide Donors; D012977:Sodium Nitrite; D020156:Salicylic Acid