Vinylamycin, a new depsipeptide antibiotic, from Streptomyces sp.
A new depsipeptide antibiotic, vinylamycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MI982-63F1, was identified as a member of Streptomyces. Vinylamycin was isolated from the culture broth by extraction with EtOAc and purified by crystallization from EtOAc. The structure of vinylamycin was determined by spectroscopic analysis and degradation studies. Vinylamycin showed antimicrobial activities against Gram-positive bacteria including MRSA.
Igarashi
M
M
Institute of Microbial Chemistry, Tokyo, Japan.
Shida
T
T
Sasaki
Y
Y
Kinoshita
N
N
Naganawa
H
H
Hamada
M
M
Takeuchi
T
T
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001426:Bacterial Proteins; D002478:Cells, Cultured; D047630:Depsipeptides; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides; D013302:Streptomyces
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047630:Depsipeptides; D010455:Peptides; C402693:vinylamycin