title: Evaluation of Helicobacter pylori in gastric MALT-type lymphoma: differences between histologic and serologic diagnosis.
abstract: Helicobacter pylori provides the pathogenic background for the development of gastric MALT-type lymphoma. The assessment of H. pylori is limited by the accuracy of the detection method used. Especially in patients with low-grade MALT-type lymphoma, the H. pylori status is the crucial question for therapeutic management. In this study, 60 patients with gastric MALT-type lymphoma. (lowgrade, 22; high-grade, 38) were investigated for the presence of H. pylori by histologic and serologic means. In 98% of the patients with MALT-type lymphoma, H. pylori-specific IgG serum antibodies were detected. In contrast, on histologic examination, H. pylori was found only in 78% of the patients (low-grade, 77%; high-grade, 79%). In this study, a discrepancy between serologic and histologic evaluation of the H. pylori status in gastric MALT-type lymphoma was found. Therefore, a H. pylori eradication therapy in low-grade MALT-type lymphoma, which often leads to a complete tumor regression, should not be excluded as a first line therapy because of a negative H. pylori status on histologic examination.
authors.affiliation: Institut für Pathologie, Universität Würzburg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Eck
authors.forename: A
authors.initials: A
authors.lastname: Greiner
authors.forename: B
authors.initials: B
authors.lastname: Schmausser
authors.forename: H
authors.initials: H
authors.lastname: Eck
authors.forename: M
authors.initials: M
authors.lastname: Kolve
authors.forename: W
authors.initials: W
authors.lastname: Fischbach
authors.forename: P
authors.initials: P
authors.lastname: Strecker
authors.forename: H K
authors.initials: HK
authors.lastname: Müller-Hermelink
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis* / Q000382:microbiology; D013270:Stomach / Q000382:microbiology / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G