Molecular pathology of allergic disease: I: lower airway disease.
Asthma is a complex disorder associated with eosinophil infiltration and the activation of T lymphocytes within the airways. Recent advances in the pathophysiologic mechanisms of asthma point to the importance of eosinophil-basophil progenitor cells and a family of transcription factors that underlie the development of T(H)2-type responses. Further research is needed to address the development of chronic inflammatory changes, the role of profibrotic cytokines, and especially their reliance on eosinophils in the lungs.
Hamid
Q A
QA
Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada.
Minshall
E M
EM
D001249:Asthma / Q000378:metabolism / Q000473:pathology; D001982:Bronchial Diseases / Q000378:metabolism* / Q000473:pathology; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism* / Q000473:pathology*; D014157:Transcription Factors / Q000502:physiology
D018925:Chemokines; D016207:Cytokines; D014157:Transcription Factors