Studies on antidiarrhoeal activity of Punica granatum seed extract in rats.
Methanol extract of Punica granatum seed was evaluated for antidiarrhoeal activity against different experimental models of diarrhoea in rats. P. granatum seed extract treated animals showed significant inhibitory activity against castrol-oil induced diarrhoea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastro-intestinal motility in charcoal meal test in rats. The results obtained established the efficacy of P. granatum seed extract as an antidiarrhoeal agent.
Das
A K
AK
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
Mandal
S C
SC
Banerjee
S K
SK
Sinha
S
S
Das
J
J
Saha
B P
BP
Pal
M
M
D000818:Animals; D000930:Antidiarrheals / Q000627:therapeutic use*; D002368:Castor Oil / Q000009:adverse effects; D015232:Dinoprostone / Q000009:adverse effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D007194:India; D008297:Male; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil; D015232:Dinoprostone