No effect of immunosuppression with cyclosporin A detected on bone ingrowth into cancellous allo- and xenografts in the rat.
We studied the effects of the immunosuppressant cyclosporin A on bone ingrowth into allo- and xenografts in the rat using titanium bone chambers. The bone chambers were implanted bilaterally in the tibia. Each rat had one allograft and one xenograft. At 6 weeks the distance of soft tissue and bone ingrowth was measured on histological slides. In xenografts, soft-tissue ingrowth was only slightly less than in allografts, but the ingrown tissue became much less ossified. These differences were unaffected by cyclosporin A treatment, suggesting that the lesser amount of bone formation in xenografts is only weakly associated with T-cell-dependent immune reactions.
Ekelund
A
A
Department of Orthopedics, St. Göran's Hospital, Stockholm, Sweden. anders.ekelund@stg.sll.se
Aspenberg
P
P
Nilsson
O
O
D000818:Animals; D016025:Bone Transplantation / Q000379:methods*; D016572:Cyclosporine / Q000009:adverse effects* / Q000276:immunology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D016348:Osseointegration / Q000187:drug effects* / Q000276:immunology*; D011817:Rabbits; D011877:Radionuclide Imaging; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D014183:Transplantation, Heterologous / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology*
D007166:Immunosuppressive Agents; D016572:Cyclosporine