Kaposi's sarcoma following malignant mesothelioma.
We report the unusual occurrence of Kaposi's sarcoma following asbestos-related malignant mesothelioma, in a human deficiency virus (HIV)-negative Italian man. Seropositivity to human herpes virus 8 (HHV8) was documented at the time of mesothelioma diagnosis and preceded the onset of Kaposi' sarcoma with a time lapse of 13 months. HHV8 DNA was detected by polymerase chain reaction in lesional Kaposi's sarcoma but not within mesothelioma. By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells. Besides the possibility of a casual association, we hypothesize that mesothelioma-linked factors may have contributed to the development of Kaposi's sarcoma in the presence of HHV8 infection.
Ascoli
V
V
Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy. nardi@axrma.uniroma1.it
Scalzo
C C
CC
Andreoni
M
M
Manente
L
L
Pistilli
A
A
Lo Coco
F
F
D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000235:genetics; D018023:HIV Seronegativity; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008654:Mesothelioma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000821:virology; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D010997:Pleural Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D016133:Polymerase Chain Reaction; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000821:virology; D012878:Skin Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000821:virology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D017931:DNA Primers; D004273:DNA, Neoplasm; D004279:DNA, Viral; D015850:Interleukin-6; D010982:Platelet-Derived Growth Factor