Enzymatic synthesis of nucleotide sugars.
The present review gives a survey on the biosynthetic pathways of nucleotide sugars which are important for the in vitro synthesis of mammalian glycoconjugates. With respect to the use of these enzymes in glycotechnology the availability as recombinant enzymes from different sources, the large-scale synthesis of nucleotide sugars and their in situ regeneration in combination with glycosyltransferases are summarized and evaluated.
Bülter
T
T
Institute of Enzyme Technology, University of Düsseldorf, Research Center, Jülich, Germany.
Elling
L
L
D000818:Animals; D002240:Carbohydrate Sequence; D004798:Enzymes / Q000378:metabolism*; D016695:Glycosyltransferases / Q000378:metabolism; D006156:Guanosine Diphosphate Sugars / Q000096:biosynthesis; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000096:biosynthesis* / Q000737:chemistry; D011994:Recombinant Proteins / Q000378:metabolism; D014539:Uridine Diphosphate Sugars / Q000096:biosynthesis
D004798:Enzymes; D006156:Guanosine Diphosphate Sugars; D009711:Nucleotides; D011994:Recombinant Proteins; D014539:Uridine Diphosphate Sugars; D016695:Glycosyltransferases