Conditioned taste aversion produced by inhibitors of fatty acid oxidation in rats.
The aversive effects of mercaptoacetate (MA) and methyl palmoxirate (MP) were examined in the present experiment. We used a conditioned taste aversion (CTA) paradigm for Sprague-Dawley rats maintained on a low- or high-fat diet, and determined that MA and MP both produce profound aversions to a novel saccharin solution. Because it is known that the stimulation of food intake brought about by MA administration is blocked by destruction of vagal afferents. we repeated the CTA experiment in control and capsaicin-treated rats. Results show that although the capsaicin-treated rats did not increase food intake after MA administration, the CTA produced by MA remained. Therefore, the neural pathways for the aversive and orexigenic effects of MA are distinct. We conclude that MA and MP are aversive, and that the aversive signal generated by MA does not involve vagal afferents or other fibers damaged by capsaicin.
Singer
L K
LK
Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA.
York
D A
DA
Berthoud
H R
HR
Bray
G A
GA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002334:Carnitine O-Palmitoyltransferase / Q000037:antagonists & inhibitors; D003214:Conditioning, Classical / Q000187:drug effects*; D004435:Eating / Q000187:drug effects; D004852:Epoxy Compounds / Q000494:pharmacology*; D044943:Fatty Acid Desaturases / Q000037:antagonists & inhibitors; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013649:Taste / Q000187:drug effects*; D013864:Thioglycolates / Q000494:pharmacology*
D004852:Epoxy Compounds; D005227:Fatty Acids; D011422:Propionates; D013864:Thioglycolates; C017487:2-mercaptoacetate; D044943:Fatty Acid Desaturases; D002334:Carnitine O-Palmitoyltransferase; C017522:methyl 2-tetradecylglycidate