title: Development of a new type nozzle and spray-drier for industrial production of fine powders.
abstract: Sophisticated nozzle and spray-drier were newly developed. The nozzle type was that of four-phase spraying, where two liquid streams and two air streams were blown off. The spray pattern from the nozzle was of a hollow-cone type. Mean diameter of droplets in the mist was 13.2 microm in weight average in the condition of blowing at 776 g/min in air flow and 500 ml/min in liquid flow. That is, the weight-based flow ratio of air to liquid was as small as 1. 55. The geometric standard deviation of the droplet size was less than 1.65. This nozzle was still available for a concentrated suspension up to 27% solid without formation of the sludge on the orifice. Thus, fine powder with 1.99 microm in mean diameter was obtained by means of the nozzle and the spray-drier newly developed by us. These are promising for industrial production of the fine powder with low energy and high recovery.
authors.affiliation: Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hino
authors.forename: S
authors.initials: S
authors.lastname: Shimabayashi
authors.forename: N
authors.initials: N
authors.lastname: Ohnishi
authors.forename: M
authors.initials: M
authors.lastname: Fujisaki
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: O
authors.initials: O
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Kawashima
authors.forename: K
authors.initials: K
authors.lastname: Nagao
mesh_terms: D004867:Equipment Design; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D011208:Powders; D013678:Technology, Pharmaceutical / Q000295:instrumentation*
chemical_list: D011208:Powders