title: High-dose intravenous glucagon in severe tricyclic poisoning.
abstract: A case of dothiepin poisoning complicated by cardiogenic shock is described. Hypotension was resistant to conventional inotropes but responded rapidly to high-dose intravenous glucagon. Glucagon should be considered as a useful therapeutic positive inotrope and a potentially antiarrhythmic agent in severe tricyclic antidepressant overdose.
authors.affiliation: Department of General Medicine, Pilgrim Hospital, Boston, UK.
authors.forename: P R
authors.initials: PR
authors.lastname: Sensky
authors.forename: S A
authors.initials: SA
authors.lastname: Olczak
mesh_terms: D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004308:Dothiepin / Q000506:poisoning*; D004334:Drug Administration Schedule; D062787:Drug Overdose; D005260:Female; D005934:Glucagon / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002316:Cardiotonic Agents; D005934:Glucagon; D004308:Dothiepin