Geographic variation in hematological variables in adult and prefledgling herring gulls (Larus argentatus) and possible associations with organochlorine exposure.
The objectives of this study were (1) to describe variation in hematological values found in adult and prefledgling herring gulls (Larus argentatus) over a large geographic area, (2) to investigate relationships between hematological variables and other physiological indices, and (3) to examine potential associations between exposure to organochlorines and hematological variables. During 1991-93, we sampled 160 breeding adult gulls from 13 colonies and 101 4-week-old gulls from 11 colonies. All colonies were in the Great Lakes ecosystem, except for two colonies on Lake Winnipeg and the Atlantic coast. The hematological values measured in this study were similar to published values for herring gulls and related species. Significant intersite differences were found in hematological variables. Sex had little or no influence on leukocyte variables. Adults had lower total leukocyte counts and higher heterophil to lymphocyte ratios than chicks. PCV was lower in adult females than males. In adults, total leukocyte and total heterophil numbers were negatively associated with liver activity of ethoxyresorufin-O-deethylase (EROD) and concentrations of highly carboxylated porphyrins (HCPs), two biomarkers of organochlorine exposure. Total leukocyte and total heterophil numbers were positively associated with liver concentrations of DDE (1, 1-dichloro-2,2-bis(p-chlorophenyl)ethylene), and total lymphocytes were associated positively with PCB (polychlorinated biphenyl) and HCP concentrations. The heterophil to lymphocyte ratio was negatively associated with liver EROD activity and HCPs. In chicks, there was a positive association between the heterophil to lymphocyte ratio and HG-TEQs (dioxin toxicity equivalents calculated using herring gull-specific equivalency factors). PCV was associated with some measures of contaminant exposure in adults and chicks. Additional research is needed to elucidate causal relationships between hematological indices and such factors as contaminants, disease, and nutrition.
Grasman
K A
KA
Department of Biological Sciences, Wright State University, Dayton, Ohio 45435, USA.
Scanlon
P F
PF
Fox
G A
GA
D000367:Age Factors; D000818:Animals; D001717:Birds / Q000097:blood / Q000378:metabolism*; D001772:Blood Cell Count; D001835:Body Weight; D019363:Cytochrome P-450 CYP1A1 / Q000097:blood; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood; D017753:Ecosystem; D006114:Great Lakes Region; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D008099:Liver / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000097:blood; D011166:Porphyrins / Q000378:metabolism; D012737:Sex Factors
D006843:Hydrocarbons, Chlorinated; D011166:Porphyrins; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls; D019363:Cytochrome P-450 CYP1A1