Recovery from hepatitis C virus-positive cryoglobulinaemic glomerulonephritis after interferon therapy.
The association between mixed cryoglobulinaemia and chronic hepatitis C virus infection has recently been described. Cryoglobulinaemic glomerulonephritis, a complication of mixed cryoglobulinaemia, is usually treated with immunosuppressive therapy, but, given the presence of viral infection, this therapy is no longer recommended. This report concerns a case of a 30-year-old patient with cryoglobulinaemic glomerulonephritis, refractory to steroid treatment, in whom recovery from hepatitis C virus infection was obtained as well as from cryoglobulinaemic glomerulonephritis after interferon therapy. The clinical symptoms and laboratory tests were normal after prolonged interferon therapy and, 3 years after the end of treatment, the patient is free from disease.
Mazzaro
C
C
Third Division of Medicine, Pordenone General Hospital, Pordenone, Italy.
Faelli
A
A
Baracetti
S
S
Mezzoran
L
L
Pussini
E
E
Zorat
F
F
Pozzato
G
G
D000328:Adult; D003449:Cryoglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D006526:Hepatitis C / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D016896:Treatment Outcome
D007372:Interferons