Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients.
Plasma sialyltransferase activity measured by incorporation of cytidine 5;-phospho[14C]acetylneuraminic acid (CMP-NeuAc) into asialofetuin was twofold higher in patients with documented atherosclerosis than in healthy donors. Kinetic studies showed that the enzyme affinity for CMP-NeuAc is the same in donors and patients. Low activity of plasma sialyltransferase in donors may be due to low blood content of this enzyme.
Gracheva
E V
EV
Institute of Experimental Cardiology, Cardiology Research Center, Russian Ministry of Health, Moscow, 121552, Russia.
Golovanova
N K
NK
Ezhov
M V
MV
Malyshev
P P
PP
Kukharchuk
V V
VV
Prokazova
N V
NV
D001161:Arteriosclerosis / Q000097:blood / Q000201:enzymology*; D016022:Case-Control Studies; D003568:Cytidine Monophosphate / Q000378:metabolism; D006801:Humans; D012799:Sialyltransferases / Q000097:blood*
D012799:Sialyltransferases; D003568:Cytidine Monophosphate