title: Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2.
abstract: An accumulation of evidence implicates leptin, insulin, glucocorticoids, proopiomelanocortin (POMC), and neuropeptide Y (NPY) interactions as being integral to metabolic control associated with neuroendocrine-endocrine functioning. Dysfunction of neuroendocrine-endocrine interactions contributes to the metabolic disturbances of diabetes mellitus type 2 (DM-2). Since Zn has a direct impact on the healthy functioning of hormonal and neuropeptide balance, it is possible that altered Zn status and metabolism in DM-2 are involved in some of the metabolic dysfunctions of DM-2.
authors.affiliation: Department of Foods and Nutrition, The University of Manitoba, Winnipeg, Canada.
authors.forename: D L
authors.initials: DL
authors.lastname: Tallman
authors.forename: C G
authors.initials: CG
authors.lastname: Taylor
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004703:Endocrine System / Q000502:physiology*; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000502:physiology; D020738:Leptin / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D011333:Pro-Opiomelanocortin / Q000502:physiology; D015032:Zinc / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D007328:Insulin; D020738:Leptin; D009479:Neuropeptides; D011333:Pro-Opiomelanocortin; D015032:Zinc