title: Preparation and activity of some novel organo-metallic complexes against Helicobacter pylori.
abstract: Some novel organo-metallic complexes were prepared by complexing the antibiotics erythromycin (CAS 114-07-8), doxycycline (CAS 564-25-0), ciprofloxacin (CAS 85721-33-1) and amoxicillin (CAS 26787-78-0) with bismuth citrate and their antibacterial activity against Helicobacter pylori and other micro-organisms were investigated. Amoxicillin-bismuth citrate had the strongest activity against H. pylori with a lowest minimum inhibitory concentration of 0.007 mg/l. The complexes exhibited moderate activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis and Bacillus subtilis. The findings suggest that the activity of these organo-metallic complexes might be specifically directed against H. pylori.
authors.affiliation: Research and Development Department, Hindustan Antibiotics Ltd., Pimpri, Pune, India. halpnq@HALPNQ.XEEPNQ.xeemail.com
authors.forename: R
authors.initials: R
authors.lastname: Nagarajan
authors.forename: S I
authors.initials: SI
authors.lastname: Mehta
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
authors.forename: W
authors.initials: W
authors.lastname: Fabry
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D016480:Helicobacter pylori / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D009942:Organometallic Compounds; C002791:bismuth tripotassium dicitrate