title: Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice.
abstract: In order to establish the pharmacological basis for the ethnomedicinal use of stem bark extracts of Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin and hypothermic restraint stress-induced gastric lesions in mice and rats, respectively. Oral administration of DCMF at doses ranging from 12.5-250 mg/kg significantly inhibited the development of gastric lesions in all the three test models. It caused significant decreases of the pyloric-ligation and bethanechol-stimulated gastric secretion, and also the free and total acidities. Besides, DCMF offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. The results indicate that DCMF from C. brasiliense possesses antisecretory, antiulcer and cytoprotective properties.
authors.affiliation: Department of Basic Sciences in Health FCM/ISC, Federal University of Mato Grosso, Campus Universitario, Cuiabá, MT, Brazil.
authors.forename: N T
authors.initials: NT
authors.lastname: Sartori
authors.forename: D
authors.initials: D
authors.lastname: Canepelle
authors.forename: P T
authors.initials: PT
authors.lastname: de Sousa
authors.forename: D T
authors.initials: DT
authors.lastname: Martins
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D007035:Hypothermia / Q000150:complications; D007213:Indomethacin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological
chemical_list: D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D007213:Indomethacin