Tropical and exotic infections. Proceedings of the 5th Liverpool Tropical School Bayer Symposium on Microbial Diseases. 14 February 1998.
In summary, MDR strains of S. typhi are both epidemic and endemic in many countries in Asia and MDR S. paratyphi A has recently emerged in Pakistan. Multiple clones may be present in a given area at any time. Fluoroquinolones and third generation cephalosporins have been used widely over the past decade to treat MDR strains. The clinical superiority of fluoroquinolones is now threatened by the rapid emergence of chromosomally mediated resistance and cephalosporin resistance is also being reported. Whether these problems can be overcome by the use of newer fluoroquinolones or cephalosporins remains to be seen. Meanwhile, furazolidone and azithromycin deserve further trials, and clinical and molecular surveillance of resistance patterns remains essential.
Beeching
N J
NJ
Hart
C A
CA
School of Tropical Medicine and *Department of Medical Microbiology and Genito-urinary Medicine, University of Liverpool, PO Box 147, Liverpool L69 3GA and †Department of Medical Microbiology and Public Health Laboratory, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN.
Duerden
B I
BI
School of Tropical Medicine and *Department of Medical Microbiology and Genito-urinary Medicine, University of Liverpool, PO Box 147, Liverpool L69 3GA and †Department of Medical Microbiology and Public Health Laboratory, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN.
D002771:Cholera / Q000453:epidemiology; D003141:Communicable Diseases; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D016873:Ehrlichiosis; D006801:Humans; D008554:Melioidosis; D010284:Paratyphoid Fever / Q000382:microbiology; D010930:Plague; D012482:Salmonella paratyphi A / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D014330:Tropical Medicine; D014435:Typhoid Fever / Q000382:microbiology