NAADP: An emerging calcium signaling molecule.
Cells possess multiple Ca(2+) stores and multiple messengers for mobilizing them. In addition to inositol trisphosphate and cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), a metabolite of NADP, is shown to be a potent Ca(2+) signaling molecule in both invertebrate and mammalian cells. This article summarizes the recent results of this newly discovered Ca(2+) signaling mechanism and explores the implications of the apparent proliferation of Ca(2+) messengers.
Lee
H C
HC
Department of Pharmacology, 6-120 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis, MN 55455, USA.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D007448:Invertebrates; D008322:Mammals; D009249:NADP / Q000031:analogs & derivatives* / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D009249:NADP; C024376:NAADP; D002118:Calcium