title: Vinylamycin, a new depsipeptide antibiotic, from Streptomyces sp.
abstract: A new depsipeptide antibiotic, vinylamycin, was isolated from the culture broth of an actinomycete strain. The producing organism, designated MI982-63F1, was identified as a member of Streptomyces. Vinylamycin was isolated from the culture broth by extraction with EtOAc and purified by crystallization from EtOAc. The structure of vinylamycin was determined by spectroscopic analysis and degradation studies. Vinylamycin showed antimicrobial activities against Gram-positive bacteria including MRSA.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Igarashi
authors.forename: T
authors.initials: T
authors.lastname: Shida
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: N
authors.initials: N
authors.lastname: Kinoshita
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001426:Bacterial Proteins; D002478:Cells, Cultured; D047630:Depsipeptides; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides; D013302:Streptomyces
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D047630:Depsipeptides; D010455:Peptides; C402693:vinylamycin