Inhibition of chemical carcinogenesis by Psoralea corylifolia seeds.
Psoralea corylifolia L. (Fabaceae) seeds are extensively used in Ayurvedic medicine. Topical application of 100 mg/kg body weight of the active fraction (AF) of P. corylifolia seeds inhibited the growth and delayed the onset of papilloma formation in mice, initiated with 7,12-dimethyl benz(a) anthracene and promoted using croton oil. The AF at the same dose, when administered orally, inhibited the growth of subcutaneously injected 20-methylcholanthrene (MCA)--induced soft tissue fibrosarcomas significantly. The AF has been shown by gas chromatography analysis to be composed of a mixture of glycerides of fatty acids.
Latha
P G
PG
Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Kerala, India.
Panikkar
K R
KR
D015127:9,10-Dimethyl-1,2-benzanthracene; D000287:Administration, Topical; D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002273:Carcinogens; D008297:Male; D008515:Medicine, Ayurvedic; D051379:Mice; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000627:therapeutic use* / Q000633:toxicity; D012639:Seeds / Q000737:chemistry; D013997:Time Factors
D016588:Anticarcinogenic Agents; D015295:Antigens, Tumor-Associated, Carbohydrate; D002273:Carcinogens; D010936:Plant Extracts; C057387:mucinous carcinoma-associated antigen; D015127:9,10-Dimethyl-1,2-benzanthracene