Genetic dissection of systemic lupus erythematosus.
Recent progress towards elucidating the genetic basis for susceptibility to systemic lupus erythematosus (SLE) has provided insights into the manner in which individual susceptibility genes contribute to disease pathogenesis. Studies in animal models of systemic autoimmunity suggest that genes in three separate pathways contribute to the initiation and progression of systemic autoimmunity. Linkage studies in humans suggest that at least some susceptibility genes mediating disease in lupus-prone mice may also contribute to susceptibility in humans.
Wakeland
E K
EK
Center for Immunology, University of Texas Southwestern Medical Center, Dallas 75235-9093, USA. edward.wakeland@email.swmed.edu
Wandstrat
A E
AE
Liu
K
K
Morel
L
L
D000818:Animals; D015551:Autoimmunity; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics* / Q000276:immunology