title: The diagnostic value of digital rectal examination in primary care screening for prostate cancer: a meta-analysis.
abstract: OBJECTIVE
  This systematic review examines the diagnostic value of the digital rectal examination (DRE) for the diagnosis of prostate cancer.
  
  
  METHODS
  Only studies relating to unselected populations and using either biopsy or surgery as the reference standard were included. The methodological quality of the studies was used in an attempt to explain differences between studies.
  
  
  RESULTS
  Fourteen studies were eligible for selection, of which five complied with the predetermined list of 'good-quality' requirements. Between study heterogeneity was high, even within the group of high-quality studies, and could not be explained by the registered indicators of methodological quality.
  
  
  CONCLUSIONS
  In this setting, the DRE appears to be a test with a high specificity and negative predictive value, but a low sensitivity and positive predictive value. Neither a positive nor a negative test result is sufficient to enable conclusions without further confirmation.
authors.affiliation: Department of General Practice, University of Maastricht, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Hoogendam
authors.forename: F
authors.initials: F
authors.lastname: Buntinx
authors.forename: H C
authors.initials: HC
authors.lastname: de Vet
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010173:Palpation / Q000379:methods*; D011237:Predictive Value of Tests; D011320:Primary Health Care / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D012007:Rectum; D012680:Sensitivity and Specificity