title: The bottom line for prediction of residue solvent accessibility.
abstract: A simple method of predicting residue solvent accessibilities in proteins is described, with the intention that it should be used as a baseline by which more sophisticated approaches to prediction can be judged. Comparison with existing methods of predicting residue burial reveals that their performance is often little better than that of the baseline method. The problem of comparing different prediction methods is shown to be complicated by the proliferation of different schemes for classifying residue burial.
authors.affiliation: Pharmacy Department, King's College London, Manresa Road, London SW3 6LX, UK. foop@sg4.pcy.kcl.ac.uk
authors.forename: C J
authors.initials: CJ
authors.lastname: Richardson
authors.forename: D J
authors.initials: DJ
authors.lastname: Barlow
mesh_terms: D000465:Algorithms; D016571:Neural Networks, Computer; D011336:Probability; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D011506:Proteins; D012997:Solvents