A clonal view of alphabeta T cell responses.
Quantitative analyses of antigen (Ag)-specific alphabeta T cell populations have provided a large body of information on the natural course of T cell immune responses. New tools are now available to determine the clonal composition of Ag-specific pools in individual responders, an approach which offers direct insights into the generation of T cell immune responses and establishment of protective immunity. The present review discusses the parameters that determine the composition of Ag-specific T cell responses. Emphasis is placed on the role of the naive alphabeta T cell repertoire and on the dynamics of individual Ag-specific T cell clones during the successive phases of an immune response.
Bousso
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P
Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 25 rue du Dr Roux, Paris, Cedex 15, 75015-75724, France. bousso@pasteur.fr
Kourilsky
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P
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology*; D002999:Clone Cells; D007156:Immunologic Memory; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D016693:Receptors, Antigen, T-Cell, alpha-beta