MTSEA potentiates 5-HT3 receptors containing the nicotinic alpha4 subunit.
In order to study the subunit composition of 5-HT3 receptors (5-HT3R), we report that (2-aminoethyl)methanethiosulfonate (MTSEA) can enhance the function of both nicotinic ACh receptors (nAChRs) comprised of alpha4/beta2 subunits, and heteromeric channels assembled from serotonin 5-HT3R and alpha4 nAChR subunits. MTSEA has no effect on homomeric 5-HT3 receptor channels.
Kriegler
S
S
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, N.C. 27709, USA.
Sudweeks
S
S
Yakel
J L
JL
D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D005020:Ethyl Methanesulfonate / Q000031:analogs & derivatives* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D007202:Indicators and Reagents / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin / Q000494:pharmacology; D014981:Xenopus
D005020:Ethyl Methanesulfonate; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D011978:Receptors, Nicotinic; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin; C093171:methanethiosulfonate ethylammonium