Potential biomarkers for the early detection of lung cancer.
Lung cancer remains the leading cause of cancer death among men and women in the United States. Early detection of premalignant lesions provides the possibility of treatment at earlier stages. Because malignancy develops from genetic alterations, the early detection of these genetic changes should be associated with the earliest clues to transformation. This article presents an overview of detection of molecular markers and their relevance to lung cancer. In the future, such molecular markers may play a role in guiding therapy for lung cancer.
Gruidl
M E
ME
Cancer Prevention Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
Shaw Wright
G L
GL
D014408:Biomarkers, Tumor; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D009154:Mutation; D009857:Oncogenes; D011230:Precancerous Conditions / Q000235:genetics
D014408:Biomarkers, Tumor; D005819:Genetic Markers