title: Heavy-chain diseases.
abstract: This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within the germinal center.
authors.affiliation: Department of Immuno-Hematology, Hôpital Saint-Louis, Paris, France. immuno-hem@chu-stlouis.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Fermand
authors.forename: J C
authors.initials: JC
authors.lastname: Brouet
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D006362:Heavy Chain Disease / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry / Q000235:genetics
chemical_list: D007143:Immunoglobulin Heavy Chains