title: The physical imperative in circadian rhythm: a cytoskeleton-related physically resettable clock mechanism hypothesis.
abstract: Organisms maintaining circadian rhythmicity are responding to physical constraint of a 24-hour cycle. Time-cue sensing is fundamental to the clock existence, and entrainment of circadian rhythm is indeed accessible to a wide variety of geophysical stimuli. Light-dark and temperature changes are the main time-cues. Additional physical forces such as barometric pressure, electrostatic and electromagnetic fields and gravity force, display a daily cyclic behavior and can function as secondary time-cues. A conceptual framework that contains explanations to all circadian properties including cell autonomous, environmental responsiveness and self-sustained character, is still lacking. It is argued that clock responsiveness to external cues is central to the cellular clock mechanism, and therefore, the nature of the time-cues and the pathways that enable the cell to respond to physical stimuli are of central importance. A role for cytoskeleton in clock entrainment mechanism is suggested in light of cytoskeleton's major involvement in cellular mechanotransduction.
authors.affiliation: The Cohn Institute for the History and Philosophy of Science and Ideas, Tel-Aviv University, Israel. dorits@ccsg.tau.ac.il
authors.forename: D
authors.initials: D
authors.lastname: Shweiki
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010812:Physical Stimulation