title: [Effect of sodium hydroxybutyrate on carboxypeptidase H activity and on angiotensin-converting enzyme in different regions of the rat brain].
abstract: It is revealed, that analogue of the gamma-aminobutyric acid--sodium hydroxybutyrate causes decrease of activities carboxypeptidase H and angiotensin converting enzyme in pituitary gland, hypothalamus and striatum. The most expressed changes of enzyme activities were observed in pituitary gland and hypothalamus. The activity of carboxypeptidase H changes more essentially, than one of angiotensin converting enzyme. The assumption one of mechanisms of influence the hydroxybutyric acid and, possible, the gamma-aminobutyric acid, on neuropeptides level is changes of activity of enzyme of biologically active peptides exchange is expressed.
authors.affiliation: Penza State Pedagogical University, Russian Federation.
authors.forename: A N
authors.initials: AN
authors.lastname: Vernigora
authors.forename: M T
authors.initials: MT
authors.lastname: Gengin
authors.forename: N V
authors.initials: NV
authors.lastname: Shchetinina
authors.forename: D A
authors.initials: DA
authors.lastname: Spiridonov
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats
chemical_list: D006885:Hydroxybutyrates; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D043423:Carboxypeptidase H