title: Blunting of pulmonary but not systemic vasodilator responses to dobutamine in newborn lambs.
abstract: Little is known about the changes in systemic and pulmonary vascular responses to dobutamine that occur during postnatal development. To address this question, vascular pressures and cardiac output were measured in anesthetized 1- to 2-d-old (n = 6), 7- to 10-d-old (n = 7), and 6- to 8-wk-old lambs (n = 6) while dobutamine was infused incrementally in the dose range of 0.5-40 microg x kg(-1) x min(-1). Dobutamine reduced pulmonary vascular resistance in the three age groups (all p<0.005). However, although this reduction reached a plateau over the infusion range of 15-40 microg x kg(-1) x min(-1) at all ages, its magnitude was less (p<0.02) in 1- to 2-d-old lambs (24+/-2%) than in 7- to 10-d-old (41+/-7%) or 6- to 8-wk-old lambs (42+/-6%). Over the same infusion range, dobutamine produced a fall in systemic vascular resistance (all p<0.005) that was proportionally similar in 1- to 2-d-old (51+/-3%), 7- to 10-d-old (48+/-3%), and 6- to 8-wk-old lambs (42+/-6%). In separate subgroups of 1- to 2-d-old lambs, pulmonary and systemic responses to dobutamine were not affected by pretreatment with selective alpha1-, beta1-, or beta2-adrenoceptor antagonists. Taken together, these findings suggest that the pulmonary but not systemic vasodilator response to dobutamine in lambs is blunted in the initial days after birth, and that this pulmonary effect is not directly related to the adrenoceptor-stimulating properties of dobutamine.
authors.affiliation: Institute of Reproduction and Development, Monash Medical Centre and Monash University, Clayton, Victoria, Australia.
authors.forename: J J
authors.initials: JJ
authors.lastname: Smolich
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: D J
authors.initials: DJ
authors.lastname: Penny
mesh_terms: D018674:Adrenergic Antagonists / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D004280:Dobutamine / Q000494:pharmacology*; D008168:Lung / Q000098:blood supply; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D018674:Adrenergic Antagonists; D014665:Vasodilator Agents; D004280:Dobutamine