Nicotine microaerosol inhaler.
OBJECTIVE
To measure the droplet size distribution of a nicotine pressurized metered-dose inhaler using a nicotine in ethanol solution formulation with hydrofluoroalkane as propellant.


METHODS
Sizing was performed at room temperature by multistage liquid impinger and quartz crystal impactor.


RESULTS
The mass median aerodynamic diameter of the nicotine aerosol produced was measured at 1.6 mm by multistage liquid impinger and 1.5 mm by quartz crystal impactor.


CONCLUSIONS
The inhaler formulation used produces a microaerosol of sufficiently fine droplet size that mimics the puff-by-puff pulmonary arterial bolus nicotine delivery of tobacco smoke. The absence of combustion products such as heat, carcinogens and carbon monoxide permits safer nicotine delivery via the inhaler than is possible via smoked tobacco.
Andrus
P G
PG
Aerosol Research Laboratory, McMaster University, Hamilton, Canada. andrusp@fhs.csu.McMaster.CA
Rhem
R
R
Rosenfeld
J
J
Dolovich
M B
MB
D000335:Aerosol Propellants / Q000008:administration & dosage; D000336:Aerosols; D006845:Hydrocarbons, Fluorinated / Q000008:administration & dosage; D009330:Nebulizers and Vaporizers; D009538:Nicotine / Q000008:administration & dosage*; D010316:Particle Size; D012996:Solutions; D005466:Fluorocarbons
D000335:Aerosol Propellants; D000336:Aerosols; D006845:Hydrocarbons, Fluorinated; D009538:Nicotine; D012996:Solutions; C094049:apaflurane; D005466:Fluorocarbons