title: Immunohistochemical study of annexin V expression in placentae of preeclampsia.
abstract: We investigated the clinical significance of annexin V in the placentae with preeclampsia and found: (1) annexin V was detected on trophoblasts in the placentae and the staining intensity of annexin V in the placentae from such patients was reduced when compared to normal placentae; (2) as expression of annexin V was reduced, the gestosis index from patients with preeclampsia was elevated and the standard deviation value in the infant's standard weight was decreased; plasma level of the fibrin degradation products and thrombin-antithrombin III complex from patients were elevated as the expression of anexin V was reduced. These results suggest that the reduced expression of annexin V in the placentae from patients with preeclampsia may lead to a hypercoagulable state in the intervillous space and may be associated with the development of intrauterine growth restriction.
authors.affiliation: Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Shu
authors.forename: M
authors.initials: M
authors.lastname: Sugimura
authors.forename: N
authors.initials: N
authors.lastname: Kanayama
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Terao
mesh_terms: D017304:Annexin A5 / Q000032:analysis*; D000990:Antithrombin III / Q000032:analysis; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D010447:Peptide Hydrolases / Q000032:analysis; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D017304:Annexin A5; D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases