title: [(2E)-4-hydroxy-2-nonenal--an active component of a new natural antimicrobial substance].
abstract: A mixture of water-soluble oxidation products of Sardinops melanosticta sardine oil was found to contain (2E)-4-hydroxy-2-nonenal. This was isolated by column chromatography on silica gel and reversed-phase HPLC. Its structure was elucidated by physicochemical methods. The activity of (2E)-4-hydroxy-2-nonenal against test cultures of Escherichia coli, Staphylococcus aureus, and Bacillus subtilis was about 20% of the total antimicrobial activity of the preparation.
authors.affiliation: Pacific Research Fishery Center, Vladivostok, Russia. root@tinro.marine.su
authors.forename: V G
authors.initials: VG
authors.lastname: Rybin
authors.forename: D V
authors.initials: DV
authors.lastname: Kuklev
authors.forename: T M
authors.initials: TM
authors.lastname: Byval'tseva
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Blinov
authors.forename: V N
authors.initials: VN
authors.lastname: Akulin
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000187:drug effects; D005395:Fish Oils / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000447:Aldehydes; D000900:Anti-Bacterial Agents; D005395:Fish Oils; C027576:4-hydroxy-2-nonenal