[The efficacy of cefepime (Maxipime) in the treatment of abdominal sepsis in surgical patients].
The efficacy of cefepime in the treatment of 46 patients operated for general peritonitis of various genesis and severity (APACHE II not greater than 35) was studied. Cefepime was used in a dose of 2 g administered every 12 hours as slow intravenous infusions in 0.9 per cent sodium chloride solution in combination with metronidazole administered intravenously in a dose of 7.5 mg/kg body weight. The treatment course was 4 to 15 days. 45 patients were given diflucan for the prophylaxis of fungal superinfection, 3 patients were given aminoglycoside antibiotics (netilmicin or amikacin) and 2 patients were given vancomycin per os. The favourable clinical effect of the cefepime therapy was stated in 38 patients (82.6 per cent) including 4 out of 10 patients with initial APACHE II > 15. 101 isolates of aerobic gram-negative and gram-positive microbes from 38 patients treated with cefepime in combination with metronidazole were tested to estimate the bacteriological efficacy of the therapy and it was shown that only 5.9 per cent of them was resistant. The pathogen eradication was stated in 84.2 per cent of the patients.
Gel'fand
E B
EB
Chair of Surgery Faculty with Course of Anesthesiology and Reanimatology, Russian State Medical University, Moscow.
Belotserkovskiĭ
B Z
BZ
Alekseeva
E A
EA
Tsedenzhapov
E Ts
ETs
Karabak
V I
VI
Gel'fand
B R
BR
D018806:APACHE; D000005:Abdomen; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000077723:Cefepime; D002511:Cephalosporins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications / Q000601:surgery; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D013997:Time Factors
D000890:Anti-Infective Agents; D002511:Cephalosporins; D008795:Metronidazole; D000077723:Cefepime