title: Specific cell-mediated immunity in fish.
abstract: This review describes the fish immune system, focusing on specific cell-mediated immunity. Specific in vivo cell-mediated immune responses have been shown by allograft rejection, graft-versus-host reaction (GVHR) and delayed hypersensitivity reaction (DTH). Recent in vitro studies also showed specific cell-mediated cytotoxicity against allogeneic target cells. These in vivo and in vitro experiments strongly suggest the presence of cytotoxic T cells in fishes. Also described are current studies on shark and trout MHC class I polymorphism and function that demonstrate strong similarities between fish and mammals.
authors.affiliation: National Research Institute of Aquaculture, Tamaki, Mie, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakanishi
authors.forename: K
authors.initials: K
authors.lastname: Aoyagi
authors.forename: C
authors.initials: C
authors.lastname: Xia
authors.forename: J M
authors.initials: JM
authors.lastname: Dijkstra
authors.forename: M
authors.initials: M
authors.lastname: Ototake
mesh_terms: D000818:Animals; D005399:Fishes / Q000235:genetics / Q000276:immunology*; D005805:Genes, MHC Class I / Q000235:genetics / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology*; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics / Q000276:immunology; D012754:Sharks / Q000235:genetics / Q000276:immunology