title: [The effect of the regimen for administering antibacterial therapy on the manifestations of endogenous intoxication in patients operated on for lung cancer].
abstract: It is shown, that tumour and progression of the tumour process cause a change in the normal microflora of the tracheobronchial tree. Highlighted in the article are causes making for an origination of inflammatory processes, infectious complications in those patients presenting with oncological diseases. Regimens of antibacterial therapy are given. The following methods of investigation into bodily endogenous intoxication have been developed: malonic dialdehyde, superoxiddismutase, and coefficient K. Toxic effects of antibiotics on the organism were found out to be dependent on the regimen of their administration. Perioperative antibiotic prophylaxis was proved to be superior from the standpoint of the clinical practice to the postoperative one.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Mykhaĭlovych
mesh_terms: D019072:Antibiotic Prophylaxis / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D002439:Cefotaxime / Q000008:administration & dosage*; D002511:Cephalosporins / Q000008:administration & dosage*; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000150:complications* / Q000601:surgery; D008315:Malondialdehyde / Q000097:blood; D011182:Postoperative Care; D011300:Preoperative Care; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D013482:Superoxide Dismutase / Q000097:blood; D013997:Time Factors
chemical_list: D015415:Biomarkers; D002511:Cephalosporins; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D002439:Cefotaxime