title: Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinaemia treated with cyclosporin A.
abstract: Lymphoid interstitial pneumonitis (LIP) is a rare clinicopathological entity that may be associated with common variable immune deficiency (CVID) and may lead to respiratory failure and death. Some patients may respond to prolonged corticosteroid treatment. We hypothesised that, in view of the predominant T cell nature of LIP, cyclosporin A would be a more appropriate choice of immunosuppressive agent and report the first case of its successful use in a woman with LIP associated with CVID.
authors.affiliation: Osler Chest Unit, Churchill Hospital, Oxford Radcliffe Trust, Oxford OX3 7LJ, UK.
authors.forename: C W
authors.initials: CW
authors.lastname: Davies
authors.forename: M C
authors.initials: MC
authors.lastname: Juniper
authors.forename: W
authors.initials: W
authors.lastname: Gray
authors.forename: F V
authors.initials: FV
authors.lastname: Gleeson
authors.forename: H M
authors.initials: HM
authors.lastname: Chapel
authors.forename: R J
authors.initials: RJ
authors.lastname: Davies
mesh_terms: D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy*; D013601:T-Lymphocytes / Q000502:physiology
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine