title: The effect of probiotic LSP 122 on the control of post-weaning diarrhoea syndrome of piglets.
abstract: Post-weaning diarrhoea syndrome (PWDS) of piglets is caused mainly by enterotoxigenic Escherichia coli (ETEC) strains. A new in-feed probiotic, LSP 122 (Alpharma), containing viable spores of Bacillus licheniformis was tested for its efficacy to control PWDS in piglets in a low health-status farm, using four groups with a total of 256 weaned piglets for a 28-day period. One group (negative control) was offered antimicrobial-free and probiotics-free fed, one group was offered feed supplemented with 10(6)viable spores of Bacillus toyoi (Toyocerin(R)) per gram of feed and two groups were offered feed supplemented with 10(6)and 10(7)viable spores of B. licheniformis per gram of feed, respectively, and were compared with regard to the appearance of clinical signs, mortality, weight gain and feed conversion. The results showed that all groups supplemented with probiotics exhibited a reduced incidence and severity of diarrhoea. Mortality in all probiotic supplemented pigs was significantly lower compared with the negative control group (P<0.05). The evaluation of the weight gain data, as well as feed conversion ratio, indicated that the three treated groups performed remarkably better than the negative control group (P<0.05) and the group receiving the high inclusion of LSP 122 performed better than the two other groups receiving probiotics (P<0.05). No ETEC strains were detected on day 22 in the high inclusion of LSP 122 and Toyocerin groups as compared with the untreated control. It was concluded that the high dosage schedule of LSP 122, providing 10(7)viable spores of B. licheniformis per g of feed, is a very useful agent for the control of PWDS due to ETEC.
authors.affiliation: Clinic of Productive Animal Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, 54006, Greece.
authors.forename: S C
authors.initials: SC
authors.lastname: Kyriakis
authors.forename: V K
authors.initials: VK
authors.lastname: Tsiloyiannis
authors.forename: J
authors.initials: J
authors.lastname: Vlemmas
authors.forename: K
authors.initials: K
authors.lastname: Sarris
authors.forename: A C
authors.initials: AC
authors.lastname: Tsinas
authors.forename: C
authors.initials: C
authors.lastname: Alexopoulos
authors.forename: L
authors.initials: L
authors.lastname: Jansegers
mesh_terms: D000818:Animals; D003967:Diarrhea / Q000517:prevention & control / Q000662:veterinary*; D004927:Escherichia coli Infections / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D006115:Greece; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014886:Weaning