Evaluation of toxicity of intravitreal ceftazidime, vancomycin, and ganciclovir in a silicone oil-filled eye.
OBJECTIVE
To evaluate the toxicity of intravitreal drugs in an eye filled with silicone oil for prolonged internal retinal tamponade.


METHODS
Vitrectomy was performed in 21 rabbit eyes, and the vitreous was replaced with silicone oil. Different concentrations of various drugs (ceftazidime, vancomycin, and ganciclovir) were injected intravitreally.


RESULTS
Silicone oil increased the toxicity of these drugs, which were injected in previously determined nontoxic doses, possibly because of a reduction of the preretinal space. Injecting one quarter of the known nontoxic dose failed to show any toxicity.


CONCLUSIONS
Nontoxic concentrations of intravitreal drugs can cause toxicity in a silicone-filled eye.
Hegazy
H M
HM
LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, USA.
Kivilcim
M
M
Peyman
G A
GA
Unal
M H
MH
Liang
C
C
Molinari
L C
LC
Kazi
A A
AA
D000818:Animals; D002442:Ceftazidime / Q000008:administration & dosage / Q000633:toxicity*; D004341:Drug Evaluation; D004347:Drug Interactions; D004596:Electroretinography; D015774:Ganciclovir / Q000008:administration & dosage / Q000633:toxicity*; D007267:Injections; D011817:Rabbits; D011897:Random Allocation; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D012827:Silicone Oils / Q000008:administration & dosage*; D014640:Vancomycin / Q000008:administration & dosage / Q000633:toxicity*; D014821:Vitrectomy; D014822:Vitreous Body
D012827:Silicone Oils; D014640:Vancomycin; D002442:Ceftazidime; D015774:Ganciclovir