Potential role of peripheral benzodiazepine receptors in inflammatory responses.
This study investigates the anti-inflammatory effects of 1-(2-chlorophenyl)-N-methyl-N(1-methylpropyl)-3-isoquinoline carboxamide and 7-chloro-5-(4-chlorophenyl)-1, 3-dihydro-1-methyl-2-H-1,4-benzodiazepin-2-one in paw oedema induced by carrageenan in mice. Pretreatment (24 h) with both ligands inhibited oedema formation in at different doses (0.00001-10 mg/kg, i.p.) with range of inhibition of 25% to 70%, in animals with or without adrenal glands. These results demonstrate, for the first time, an in vivo anti-inflammatory property of peripheral benzodiazepine receptor ligands.
Torres
S R
SR
Department of Pharmacology, Center of Biological Sciences, Universidade Federal de Santa Catarina, Rua Ferreira Lima, No. 82, 88015-420, Florianópolis, Brazil.
Nardi
G M
GM
Ferrara
P
P
Ribeiro-do-Valle
R M
RM
Farges
R C
RC
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D006614:Hindlimb / Q000473:pathology; D007249:Inflammation / Q000503:physiopathology / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D051379:Mice; D011963:Receptors, GABA-A / Q000502:physiology*
D000893:Anti-Inflammatory Agents; D001570:Benzodiazepinones; D007546:Isoquinolines; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam; D002351:Carrageenan; C037850:PK 11195