title: Phosphorylation of the synthetic octapeptide pyroGlu-ASP-ASP-SER-ASP-GLU-GLU-ASN and binding to DNA in presence of divalent cations.
abstract: Small acidic peptides involved in gene expression have been isolated from prokaryotic and eukaryotic cells. Synthetic peptides, designed on the basis of native peptides characteristics, show a biological activity similar to that of native peptides in in vitro reconstituted systems. These synthetic peptides are able to bind to DNA in presence of divalent cations (Cu2+, Fe2+, Mg2+) and salt/ethanol.
authors.affiliation: Dipartimento di Biologia Cellulare e Molecolare, Sez. di Fisiologica e Biofisica, Università di Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cardellini
authors.forename: D
authors.initials: D
authors.lastname: Ponti
authors.forename: G L
authors.initials: GL
authors.lastname: Gianfranceschi
mesh_terms: D000818:Animals; D047390:Casein Kinase II; D002413:Cations, Divalent / Q000378:metabolism*; D002417:Cattle; D004247:DNA / Q000378:metabolism*; D000431:Ethanol; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000378:metabolism*; D010748:Phosphopeptides / Q000378:metabolism*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases; D012319:RNA Polymerase II / Q000138:chemical synthesis / Q000378:metabolism
chemical_list: D002413:Cations, Divalent; D009842:Oligopeptides; D010748:Phosphopeptides; D000431:Ethanol; D004247:DNA; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases; D012319:RNA Polymerase II