Neuroactive neurosteroids: dehydroepiandrosterone (DHEA) and DHEA sulphate.
Dehydroepiandrosterone (DHEA) and its sulphate ester (DHEAS) are neuroactive and are both imported into the brain from the circulation and produced in the nervous system. These neurosteroids have neurotrophic and excitatory effects, and further study is needed to delineate their physiological and pathological functions.
Baulieu
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College de France et Institut National de la Santé et de la Recherche Médicale, Le Kremlin-Bicêtre, France. baulieu@kb.inserm.fr
D001921:Brain / Q000378:metabolism / Q000502:physiology*; D003687:Dehydroepiandrosterone / Q000096:biosynthesis / Q000502:physiology*; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism; D006801:Humans
D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate