Specific cell-mediated immunity in fish.
This review describes the fish immune system, focusing on specific cell-mediated immunity. Specific in vivo cell-mediated immune responses have been shown by allograft rejection, graft-versus-host reaction (GVHR) and delayed hypersensitivity reaction (DTH). Recent in vitro studies also showed specific cell-mediated cytotoxicity against allogeneic target cells. These in vivo and in vitro experiments strongly suggest the presence of cytotoxic T cells in fishes. Also described are current studies on shark and trout MHC class I polymorphism and function that demonstrate strong similarities between fish and mammals.
Nakanishi
T
T
National Research Institute of Aquaculture, Tamaki, Mie, Japan.
Aoyagi
K
K
Xia
C
C
Dijkstra
J M
JM
Ototake
M
M
D000818:Animals; D005399:Fishes / Q000235:genetics / Q000276:immunology*; D005805:Genes, MHC Class I / Q000235:genetics / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000235:genetics / Q000276:immunology*; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics / Q000276:immunology; D012754:Sharks / Q000235:genetics / Q000276:immunology