Oxidized lipoproteins in blood plasma: possible marker of atherosclerosis progression.
Oxidized lipoproteins and antioxidants were detected during the course of hypercholesterolemia development in cholesterol-fed rabbits. Lipid peroxides in blood plasma and very-low-, low-, and high-density lipoproteins (beta-VLDL, LDL, and HDL) were increased during the course of hypercholesterolemia. The content of phospholipid peroxides increased in beta-VLDL and LDL in parallel to that of cholesterol, whereas the amount of alpha-tocopherol was decreased either in lipoproteins or blood plasma. Ascorbate and urate concentrations were also decreased. Lipid peroxides were positively correlated with volume and area of atherosclerotic lesions, suggesting a relation between the concentrations of lipid peroxides in blood plasma and the progression of atheromatous lesions.
Moriel
P
P
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, Brazil.
Okawabata
F S
FS
Abdalla
D S
DS
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects; D018450:Disease Progression; D006937:Hypercholesterolemia / Q000097:blood / Q000473:pathology; D008054:Lipid Peroxides / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D015415:Biomarkers; D002791:Cholesterol, Dietary; D008054:Lipid Peroxides; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol