High-dose intravenous glucagon in severe tricyclic poisoning.
A case of dothiepin poisoning complicated by cardiogenic shock is described. Hypotension was resistant to conventional inotropes but responded rapidly to high-dose intravenous glucagon. Glucagon should be considered as a useful therapeutic positive inotrope and a potentially antiarrhythmic agent in severe tricyclic antidepressant overdose.
Sensky
P R
PR
Department of General Medicine, Pilgrim Hospital, Boston, UK.
Olczak
S A
SA
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004308:Dothiepin / Q000506:poisoning*; D004334:Drug Administration Schedule; D062787:Drug Overdose; D005260:Female; D005934:Glucagon / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D012770:Shock, Cardiogenic / Q000139:chemically induced* / Q000188:drug therapy
D000929:Antidepressive Agents, Tricyclic; D002316:Cardiotonic Agents; D005934:Glucagon; D004308:Dothiepin