title: Isolation and antibacterial activity of phenylpropanoid derivatives from Ballota nigra.
abstract: In addition to the previously isolated phenylpropanoid glycosides verbascoside 1, forsythoside B 2, arenarioside 3 and ballotetroside 4, another four compounds were isolated from generative aerial parts of Ballota nigra: three phenylpropanoid glycosides, alyssonoside 5, lavandulifolioside 6 and angoroside A 7 and a non-glycosidic derivative (+)-(E)-caffeoyl-L-malic acid 8. The antibacterial activity of the five major compounds (1-4 and 8) was tested against gram-positive and gram-negative bacteria. Three of them (1-3) exhibited a moderate antimicrobial activity against Proteus mirabilis and Staphylococcus aureus including one methicillin-resistant strain.
authors.affiliation: Laboratoire de Pharmacognosie, Faculté des Sciences Pharmaceutiques et Biologiques, Lille, France.
authors.forename: N
authors.initials: N
authors.lastname: Didry
authors.forename: V
authors.initials: V
authors.lastname: Seidel
authors.forename: L
authors.initials: L
authors.lastname: Dubreuil
authors.forename: F
authors.initials: F
authors.lastname: Tillequin
authors.forename: F
authors.initials: F
authors.lastname: Bailleul
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011513:Proteus mirabilis / Q000187:drug effects* / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D010636:Phenols; D010936:Plant Extracts