title: A genetic dissection of the retinoid signalling pathway in the mouse.
abstract: To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, C.U. de Strasbourg, France.
authors.forename: M
authors.initials: M
authors.lastname: Mark
authors.forename: N B
authors.initials: NB
authors.lastname: Ghyselinck
authors.forename: O
authors.initials: O
authors.lastname: Wendling
authors.forename: V
authors.initials: V
authors.lastname: Dupé
authors.forename: B
authors.initials: B
authors.lastname: Mascrez
authors.forename: P
authors.initials: P
authors.lastname: Kastner
authors.forename: P
authors.initials: P
authors.lastname: Chambon
mesh_terms: D000818:Animals; D051379:Mice; D018345:Mice, Knockout; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000502:physiology; D047488:Retinoid X Receptors; D012176:Retinoids; D015398:Signal Transduction / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
chemical_list: D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids; D014157:Transcription Factors