Cancer-associated retinopathy.
Patients with systemic cancer may have a variety of ocular complaints. Most commonly these are metastases or adverse effects of therapy. Paraneoplastic syndromes, like cancer-associated retinopathy, rarely cause ophthalmic symptoms. We describe a patient with a malignant mixed mullerian tumor and cancer-associated retinopathy who had circulating serum antibodies to recoverin and cells positive for recoverin in the tumor. We discuss the typical clinical symptoms as well as the pathophysiology of this uncommon disorder.
Goldstein
S M
SM
Department of Ophthalmology, Scheie Eye Institute and the Hospital of the University of Pennsylvania, Philadelphia, USA.
Syed
N A
NA
Milam
A H
AH
Maguire
A M
AM
Lawton
T J
TJ
Nichols
C W
CW
D000951:Antigens, Neoplasm / Q000097:blood; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood; D004596:Electroretinography; D005136:Eye Proteins; D017809:Fatal Outcome; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005654:Fundus Oculi; D051597:Hippocalcin; D006801:Humans; D008074:Lipoproteins; D008875:Middle Aged; D018200:Mixed Tumor, Mullerian / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy; D009419:Nerve Tissue Proteins; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011241:Prednisone / Q000627:therapeutic use; D051603:Recoverin; D012164:Retinal Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D014594:Uterine Neoplasms / Q000276:immunology / Q000473:pathology* / Q000532:radiotherapy; D014792:Visual Acuity; D014794:Visual Fields
D000951:Antigens, Neoplasm; D018931:Antineoplastic Agents, Hormonal; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D005136:Eye Proteins; D008074:Lipoproteins; D009419:Nerve Tissue Proteins; C496731:RCVRN protein, human; D051603:Recoverin; D051597:Hippocalcin; D011241:Prednisone