Effect of dehydroepiandrosterone on phosphatidylserine or phosphatidylcholine bilayers: DSC and X-ray diffraction study.
The effect of dehydroepiandrosterone (DHEA) on the thermotropic and structural properties of phosphatidylserine or phosphatidylcholine membranes was investigated by differential scanning calorimetry and X-ray diffraction. At molar fractions of sterol, X (sterol), less than approximately 0.2, DHEA interacts with both types of model membranes, depressing the melting temperature and reducing the enthalpy of melting. At higher concentrations, phase separation of DHEA occurs with appearance of crystallites of the S2 monohydrate form.
Wachtel
E
E
Chemical Services Unit, The Weizmann Institute of Science, Rehovot, Israel.
Borochov
N
N
Bach
D
D
D002152:Calorimetry, Differential Scanning; D003687:Dehydroepiandrosterone / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008051:Lipid Bilayers / Q000737:chemistry*; D008567:Membranes, Artificial; D010713:Phosphatidylcholines / Q000737:chemistry*; D010718:Phosphatidylserines / Q000737:chemistry*; D013816:Thermodynamics; D014961:X-Ray Diffraction
D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D003687:Dehydroepiandrosterone