title: The black widow's versatile venom.
abstract: The structure of a tetrameric form of the spider neurotoxin, alpha-latrotoxin, has been determined by single particle cryo-electron microscopy. It reveals a pore complex with extended arms that could bind receptors involved in synaptic vesicle exocytosis.
authors.forename: H R
authors.initials: HR
authors.lastname: Saibil
mesh_terms: D000818:Animals; D001740:Black Widow Spider / Q000737:chemistry*; D002118:Calcium / Q000378:metabolism; D020285:Cryoelectron Microscopy; D005089:Exocytosis; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D008958:Models, Molecular; D020836:Protein Structure, Quaternary; D013111:Spider Venoms / Q000737:chemistry* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013572:Synaptic Vesicles / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; D013111:Spider Venoms; C020763:alpha-latrotoxin; D002118:Calcium