Hypoglycaemic effect of Musa sapientum L. in alloxan-induced diabetic rats.
Musa sapientum L. ('Ney Poovan') commonly known as 'banana' is mainly used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 0.15, 0.20 and 0.25 g/kg of chloroform extract of the Musa sapientum flowers (MSFEt) for 30 days resulted in a significant reduction in blood glucose, glycosylated haemoglobin and an increase in total haemoglobin, but in the case of 0.25 g/kg the effect was highly significant. It also prevents decrease in body weight. Oral glucose tolerance test was also performed in experimental diabetic rats in which there was a significant improvement in glucose tolerance in animals treated with MSFEt and the effect was compared with glibenclamide. Thus the study shows that MSFEt has hypoglycaemic action.
Pari
L
L
Department of Biochemistry, Annamalai University, Tamil Nadu, India.
Maheswari
J U
JU
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D002725:Chloroform / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005951:Glucose Tolerance Test; D005905:Glyburide / Q000494:pharmacology; D006454:Hemoglobins / Q000378:metabolism; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013997:Time Factors
D001786:Blood Glucose; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D002725:Chloroform; D005905:Glyburide