Mouse forebrain development. The role of Emx2 homeobox gene.
Over the last few years great progress has been made in the understanding of the formation of the mouse forebrain. Among the genes involved in this process, the mouse Emx homeobox genes Emx1 and particularly Emx2 play a primary role. Here we describe the mRNA and protein expression related to Emx2 in the developing mouse telencephalon, as well as the results obtained studying the corresponding knock-out mice. Our findings indicate a role for this gene in the specification of the forebrain via the control of cell proliferation, as well as in guiding neuronal migration during development through the cortical plate. These studies will hopefully enable us to better understand the molecular mechanisms underlying the formation of the mouse cerebral cortex as well as to establish relevant interactions between the various proteins present in this region of the brain.
Cecchi
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Molecular Developmental Biology Unit, DIBIT, Istituto Scientifico H San Raffaele, Milan, Italy.
Mallamaci
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Boncinelli
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E
D000818:Animals; D002455:Cell Division; D002540:Cerebral Cortex / Q000737:chemistry / Q000254:growth & development / Q000378:metabolism; D015870:Gene Expression; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000032:analysis / Q000235:genetics*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000235:genetics*; D009474:Neurons / Q000166:cytology / Q000502:physiology; D016548:Prosencephalon / Q000737:chemistry / Q000254:growth & development* / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis; D014157:Transcription Factors; D000099260:Empty Spiracles Homeobox Proteins
D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D000099260:Empty Spiracles Homeobox Proteins