title: Cytokines in genetic susceptibility to multiple sclerosis: a candidate gene approach. French Multiple Sclerosis Genetics Group.
abstract: The immune system is involved in the pathophysiology of multiple sclerosis (MS) but the initiating antigen(s) is not yet identified. Since cytokines control both the intensity and the quality of the immune response they may be relevant candidates for the genetic susceptibility to MS. To analyze the contribution of type 1 and type 2 cytokine and cytokine receptor genes in the genetic susceptibility to MS, we have examined, in 116 French MS sibpairs, whether there is significant linkage between MS and 15 cytokine or cytokine receptor genes using 31 highly polymorphic genetic markers. The data were analyzed using the maximum likelihood score and the transmission disequilibrium approaches. None of the candidate genes tested was significantly linked to MS on the whole population. However, after stratification of the analysis on the basis of sharing (or not) of the HLA-DRB1*1501 allele, indication of linkage was found for the IL2-RB gene. These findings suggest that the IL2-RB locus contributes to the genetic susceptibility in a subgroup of MS patients.
authors.affiliation: Laboratoire d'Immunologie Cellulaire, Hôpital Pitié-Salpêtrière, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Reboul
authors.forename: C
authors.initials: C
authors.lastname: Mertens
authors.forename: F
authors.initials: F
authors.lastname: Levillayer
authors.forename: S
authors.initials: S
authors.lastname: Eichenbaum-Voline
authors.forename: T
authors.initials: T
authors.lastname: Vilkoren
authors.forename: I
authors.initials: I
authors.lastname: Cournu
authors.forename: M C
authors.initials: MC
authors.lastname: Babron
authors.forename: O
authors.initials: O
authors.lastname: Lyon-Caen
authors.forename: F
authors.initials: F
authors.lastname: Clerget-Darpoux
authors.forename: G
authors.initials: G
authors.lastname: Edan
authors.forename: M
authors.initials: M
authors.lastname: Clanet
authors.forename: M
authors.initials: M
authors.lastname: Brahic
authors.forename: J F
authors.initials: JF
authors.lastname: Bureau
authors.forename: B
authors.initials: B
authors.lastname: Fontaine
authors.forename: R
authors.initials: R
authors.lastname: Liblau
mesh_terms: D016207:Cytokines / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*; D015375:Receptors, Interleukin-2 / Q000235:genetics
chemical_list: D016207:Cytokines; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C106559:HLA-DR15 antigen; D015375:Receptors, Interleukin-2