title: Sevoflurane, but not propofol, significantly prolongs the Q-T interval.
abstract: Prolongation of the Q-T interval may be associated with polymorphic ventricular tachycardia known as torsade de pointes, syncope and sudden death. Existing data show that isoflurane prolongs the Q-T interval, whereas halothane shortens it. The aim of this study was to determine whether sevoflurane or propofol affects the Q-T interval. Thirty female patients undergoing gynecologic surgery were randomly assigned to two groups, one receiving inhaled induction with sevoflurane and the other receiving total IV anesthesia with propofol. Before and 20 min after the induction, a six-lead electrocardiogram was recorded, and blood pressure was measured. The Q-T interval and heart rate adjusted Q-T interval (Q-Tc interval) were significantly prolonged during the administration of anesthesia with sevoflurane, while the Q-T interval was significantly shortened, and the Q-Tc interval was statistically unaffected during propofol anesthesia administration. We conclude that, in otherwise healthy female patients, sevoflurane prolongs the Q-Tc.
  
  
  CONCLUSIONS
  In this study, we evaluated the effect of sevoflurane induction and anesthesia versus propofol induction and anesthesia on the Q-T interval. Sevoflurane significantly prolonged the Q-T interval and the heart rate adjusted Q-T interval, whereas propofol shortened the Q-T interval but not the heart rate adjusted Q-T interval.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, The Leopold-Franzens-University of Innsbruck, Austria. axel.kleinsasser@uibk.ac.at
authors.forename: A
authors.initials: A
authors.lastname: Kleinsasser
authors.forename: E
authors.initials: E
authors.lastname: Kuenszberg
authors.forename: A
authors.initials: A
authors.lastname: Loeckinger
authors.forename: C
authors.initials: C
authors.lastname: Keller
authors.forename: C
authors.initials: C
authors.lastname: Hoermann
authors.forename: K H
authors.initials: KH
authors.lastname: Lindner
authors.forename: F
authors.initials: F
authors.lastname: Puehringer
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D013509:Gynecologic Surgical Procedures; D006339:Heart Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008738:Methyl Ethers / Q000009:adverse effects*; D015742:Propofol / Q000009:adverse effects*; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol