Palatal growth and chemotherapy: effects of cyclophosphamide on bone formation in the intermaxillary suture in growing rats.
OBJECTIVE
To study the effect of cyclophosphamide (Cy) on bone formation in the maxillary median suture of young rats.


METHODS
Doses of 30 mg/kg body weight of Cy were administered to 12 experimental rats at 10 and 13 days of age. A corresponding amount of 0.9% sodium chloride was given to 6 control rats at the same ages. At 31 days, the median maxillary suture was studied histologically in the experimental and control rats.


RESULTS
Structural changes of the osteogenic layers and cartilage components of the suture could be seen in the experimental rats. The thickness of the palatal bone was only 66% of that of the control rats, and the experimental rats also exhibited significantly reduced width of the suture.


CONCLUSIONS
This study shows that Cy by itself can cause disturbances in bone formation in rats.
Näsman
M
M
Department of Orthodontics, School of Dentistry, Karolinska Institutet, Huddinge, Sweden.
Forsberg
C M
CM
Lindskog
S
S
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D001846:Bone Development / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D008297:Male; D008437:Maxilla / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development*; D010159:Palate / Q000033:anatomy & histology / Q000187:drug effects* / Q000254:growth & development*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide