[Effect of some antioxidants and caffeine on xanthine dehydrogenase activity in rat liver in vitro].
The regulation of xanthine dehydrogenase activity by reductors-antioxidants (ascorbic acid, glutatione-SH, gentathione dithiothreitol, cysteine and hydrocortisone) and caffeine was investigated in the purified enzymatic preparation in vitro. It was shown, that reductors-antioxidants were incompetitor inhibitors of xanthine dehydrogenase and caffeine was a competitor-inhibitor of it. The mechanisms of inhibition of xanthine dehydrogenase activity by these agents were discussed.
Sumbaev
V V
VV
I.I. Mechnikov Odessa State University.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D014968:Xanthine Dehydrogenase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D000975:Antioxidants; D004791:Enzyme Inhibitors; D002110:Caffeine; D014968:Xanthine Dehydrogenase