[Reestablishment of plasma proteins after plasmapheresis in patients with paraproteinemic hemoblastosis].
OBJECTIVE
To study the effect of plasmapheresis (PA) on the changes in plasma total protein in the PA intervals in patients with paraproteinemic hemoblastosis (PPH).


METHODS
26 PPH patients underwent 80 PA procedures to remove macromolecular pathological proteins and diminish blood viscosity. Before PA the patients were examined hematologically, biochemically. Total protein concentration in plasma was measured before and after PA, in the removed plasma.


RESULTS
PA promoted total protein lowering in plasma to 65-85% of the baseline irrespectively of PA technique. After PA the proteins gradually rose. Contents of circulation proteins were found unrelated to the number of PA procedures and averaged 70% of the PA-removed protein.


CONCLUSIONS
The trends in recovery of plasma proteins after PA help to explain therapeutic effect in combination of PA with chemotherapy of paraproteinemic hemoblastoses.
Movshev
B E
BE
Kalinin
N N
NN
Petrov
M M
MM
Petrova
V I
VI
D001798:Blood Proteins / Q000378:metabolism*; D001809:Blood Viscosity; D006801:Humans; D009101:Multiple Myeloma / Q000097:blood* / Q000628:therapy; D010266:Paraproteins / Q000378:metabolism; D010956:Plasmapheresis; D013050:Spectrometry, Fluorescence; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000097:blood* / Q000628:therapy
D001798:Blood Proteins; D010266:Paraproteins