title: Mydriasis and acute pulmonary oedema complicating laparoscopic removal of phaechromocytoma.
abstract: This report describes the perioperative management of an adrenergic crisis occurring following insufflation of the peritoneum for planned laparoscopic surgery for phaechromocytoma. Despite preoperative alpha and beta adrenergic blockade, the occurrence of acute severe hypertension, mydriasis and pulmonary oedema prior to direct surgical manipulation caused the procedure to be abandoned. The severity of the event was unusual and most likely contributed to by haemorrhagic necrosis of the tumour releasing catecholamines. Serum levels of noradrenaline and adrenaline at the time were 744,600 and 166,940 pg.ml-1 respectively. Treatment included bolus doses of esmolol, nicardipine and urapidil (an alpha 1 adrenergic antagonist) by constant intravenous infusion and mechanical ventilation. Postoperative cerebral CT scan was normal. An abdominal CT showed central haemorrhagic necrosis of the tumour. Two weeks later, open surgical removal of the phaeochromocytoma was successfully performed under general anaesthesia. Induction of pneumoperitoneum for laparoscopy may be particularly hazardous in a patient with a phaeochromocytoma.
authors.affiliation: Department of Anesthesiology, Hospital Pellegrin-Tondu, Bordeaux, France.
authors.forename: P
authors.initials: P
authors.lastname: Tauzin-Fin
authors.forename: G
authors.initials: G
authors.lastname: Hilbert
authors.forename: M
authors.initials: M
authors.lastname: Krol-Houdek
authors.forename: P
authors.initials: P
authors.lastname: Gosse
authors.forename: P
authors.initials: P
authors.lastname: Maurette
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000601:surgery*; D002395:Catecholamines / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D010535:Laparoscopy / Q000009:adverse effects*; D008875:Middle Aged; D015878:Mydriasis / Q000209:etiology*; D010673:Pheochromocytoma / Q000378:metabolism / Q000601:surgery*; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000209:etiology*
chemical_list: D002395:Catecholamines