title: Synthesis of sesquiterpene derivatives as potential antitumor agents; elemane derivatives.
abstract: Derivatives of elema-1,3-diene were synthesized in several steps as polar analogs of beta-elemene, antitumor agent under clinical phase. The lactone ring of compound 1 was opened by LiAlH4 to give diol 2 which was selectively protected by TBDPSCl. After acetylation of the secondary alcohol, the acetylated product was ozonolyzed and reduced to give elemane derivative 4 which was converted to diolefin 8 via selenides subsequent deprotection by tetrabutylammonium fluoride gave two compounds 9, 10.
authors.affiliation: College of Pharmacy, Chonnam National University, Kwangju, Korea. bgchoi@chonnam.ac.kr
authors.forename: B G
authors.initials: BG
authors.lastname: Choi
authors.forename: E Y
authors.initials: EY
authors.lastname: Kwak
authors.forename: B H
authors.initials: BH
authors.lastname: Chung
authors.forename: W J
authors.initials: WJ
authors.lastname: Cho
authors.forename: S H
authors.initials: SH
authors.lastname: Cheon
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes