title: DNA cleavage activities of (-)-epigallocatechin, (-)-epicatechin, (+)-catechin, and (-)-epigallocatechin gallate with various kinds of metal ions.
abstract: The DNA cleavage activities of (+)-catechin (C), (-)-epicatechin (EC), (-)-epigallocatechin (EGC), and (-)-epigallocatechin gallate (EGCg) were examined with 16 different metal ions. Cu(2+) with all the catechins facilitated DNA cleavage, while Ag+ with EGC and EC showed a strong repressive effect. The other metal ions examined showed little effect.
authors.affiliation: Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: N
authors.initials: N
authors.lastname: Hoshino
authors.forename: T
authors.initials: T
authors.lastname: Ando
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002417:Cattle; D003300:Copper / Q000494:pharmacology; D004247:DNA / Q000187:drug effects* / Q000378:metabolism*; D004249:DNA Damage; D005419:Flavonoids / Q000494:pharmacology; D066298:In Vitro Techniques; D008670:Metals / Q000494:pharmacology; D016877:Oxidants / Q000494:pharmacology; D012834:Silver / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D008670:Metals; D016877:Oxidants; D012834:Silver; D003300:Copper; D002392:Catechin; D004247:DNA; C045651:epigallocatechin gallate; C057580:gallocatechol