title: Identification of tyrosine hydroxylase as an autoantigen in autoimmune polyendocrine syndrome type I.
abstract: Patients with the autosomal recessively inherited autoimmune polyendocrine syndrome type I (APS I) have autoantibodies directed against several endocrine and nonendocrine organs. In this study a new autoantigen related to this syndrome, tyrosine hydroxylase, was identified in sera from patients with alopecia areata through immunoscreening of a scalp cDNA library. Immunoreactivity against in vitro expressed tyrosine hydroxylase was found in 41 (44%) of the 94 APS I patients studied and this reactivity correlated with the presence of alopecia areata (P = 0.02). These findings further stress the importance of enzymes involved in neurotransmitter biosynthesis as important immune targets in APS I.
authors.affiliation: Department of Medical Sciences, University Hospital, Uppsala, Sweden. hakan.hedstrand@medsci.uu.se
authors.forename: H
authors.initials: H
authors.lastname: Hedstrand
authors.forename: O
authors.initials: O
authors.lastname: Ekwall
authors.forename: J
authors.initials: J
authors.lastname: Haavik
authors.forename: E
authors.initials: E
authors.lastname: Landgren
authors.forename: C
authors.initials: C
authors.lastname: Betterle
authors.forename: J
authors.initials: J
authors.lastname: Perheentupa
authors.forename: J
authors.initials: J
authors.lastname: Gustafsson
authors.forename: E
authors.initials: E
authors.lastname: Husebye
authors.forename: F
authors.initials: F
authors.lastname: Rorsman
authors.forename: O
authors.initials: O
authors.lastname: Kämpe
mesh_terms: D000506:Alopecia Areata / Q000201:enzymology / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000235:genetics / Q000276:immunology*; D005060:Europe; D015723:Gene Library; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000276:immunology; D016884:Polyendocrinopathies, Autoimmune / Q000201:enzymology / Q000235:genetics / Q000276:immunology*; D012535:Scalp / Q000201:enzymology; D013577:Syndrome; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007527:Isoenzymes; D014446:Tyrosine 3-Monooxygenase