[Isolation and uses of human stem cells].
This review summarizes recent results on the totipotency of differentiated mammalian cells, as demonstrated by nuclear transfer into enucleated egg cells, as well as very recent breakthroughs in establishing human embryonic stem cell lines. In the light of basic questions in developmental biology, these and other results on the identification and isolation of pluripotent mammalian brain stem cells are discussed with respect to their therapeutic applications and ethical implications.
Heberle-Bors
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Institut für Mikrobiologie und Genetik, Universität Wien, Osterreich. erwin@gem.univie.ac.at
D000818:Animals; D016380:Brain Tissue Transplantation; D002460:Cell Line; D019976:Cloning, Organism; D004624:Embryo Transfer; D016332:Fetal Tissue Transplantation; D006801:Humans; D012756:Sheep; D033581:Stem Cell Transplantation