Update on management of acute myocardial infarction: facilitated percutaneous coronary intervention.
Combination therapy with abciximab and reteplase and heparin allows high rates of patency 60 minutes after therapy. PTCA is facilitated by these adjunctive therapies to improve procedural outcomes. Stent implantation and blockade of the platelet GP IIb/IIIa receptor with abciximab provide potent complementary benefits allowing PTCA to be performed at a new standard of safety and efficacy. Thus the acronym FPCI stands for the use of drugs, angioplasty and stenting. Time and experience will determine the efficacy of the combined pharmacological-mechanical bridge. We believe that FPCI is the wave of the future and that in skilled hands this emergent coordinated care of acute MI has lowered and will continue to lower morbidity and mortality in acute coronary events.
Futterman
L G
LG
Department of Medicine, University of Miami School of Medicine, Fla., USA.
Lemberg
L
L
D000077284:Abciximab; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015607:Stents; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D011994:Recombinant Proteins; D006493:Heparin; C087896:reteplase; D010959:Tissue Plasminogen Activator; D000077284:Abciximab