Effect of iodine supply on neonatal thyroid volume and TSH.
A cross-sectional study was performed to prove the correlation between iodine intake and neonatal thyroid volume in a randomized group of 100 mother/newborn pairs. Thyroid volume and iodine excretion were measured by ultrasound and urinary iodine excretion, respectively. Iodine intake and, nutritional and smoking habits were estimated by questionnaire. In 89 mother/child-pairs the data were complete for all parameters and have been analyzed: 32 mothers substituted with iodine tablets, average dose 175 microg K-Iodide/day. Iodine excretion of prenatally iodine-substituted newborns increased by 62% whereas neonatal thyroid volume was reduced by 18% compared with the non-iodine-supplemented group. Smoker's newborns (n = 8) had a thyroid volume 20% larger than that of newborns of non-smokers. Neonatal TSH-screening values remained within normal limits.
Klett
M
M
University Children's Hospital, Hormonlabor, Heidelberg, Germany.
Ohlig
M
M
Manz
F
F
Tröger
J
J
Heinrich
U
U
D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency* / Q000652:urine; D008297:Male; D008403:Mass Screening / Q000379:methods; D008431:Maternal-Fetal Exchange; D015999:Multivariate Analysis; D011247:Pregnancy; D012016:Reference Values; D012907:Smoking / Q000009:adverse effects; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000187:drug effects* / Q000503:physiopathology; D013972:Thyrotropin / Q000187:drug effects / Q000378:metabolism*; D014463:Ultrasonography
D013972:Thyrotropin; D007455:Iodine