Unilateral papilloedema after hepatitis B vaccination in a migraine patient. A case report including forensic aspects.
OBJECTIVE
To report on a unilateral optic nerve reaction appearing 9-10 hours after vaccination against hepatitis B.


METHODS
To describe the case and discuss the underlying mechanisms. There was a scintillating scotoma leaving a permanent inferior notch in the visual field, but central vision was left normal and with only a slight affection of colour perception. Shortly the optic nervehead appeared engorged, then slightly ischaemic, but was hardly left with evidence of atrophy.


RESULTS
Immune-based reactions could hardly be held responsible, multiple sclerosis was unlikely, and ultrasonography excluded optic nervehead drusen. An optic nerve migraine mechanism is probable, possibly with the vaccination having acted as the trigger.
Fledelius
H C
HC
University Eye Department, Rigshospitalet, Copenhagen, Denmark.
D003118:Color Perception / Q000187:drug effects; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications*; D009898:Optic Disk / Q000187:drug effects / Q000473:pathology; D010211:Papilledema / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D014611:Vaccination / Q000009:adverse effects*; D014792:Visual Acuity / Q000187:drug effects
D017325:Hepatitis B Vaccines