[Comparison of postoperative recovery after trabeculectomy for pseudoexfoliation glaucoma and chronic primary open angle glaucoma].
BACKGROUND
A former study showed an increased biochemical and tyndallometrical concentration of proteins in the anterior chamber in eyes with pseudoexfoliation glaucoma (PEX). This may induce an increased healing process, which may reduce the effectiveness of a trabeculectomy. To evaluate the intraocular pressure (IOP) lowering effect of trabeculectomy over time in eyes with PEX and primary open angle glaucoma (POAG) a retrospective study was conducted.


METHODS
Thirty eyes of 30 patients with PEX were matched to 30 eyes of 30 patients with POAG in terms of age, glaucoma medication, and visual field loss. All patients underwent primary trabeculectomy by one surgeon without the use of antimetabolites. Maximum IOP and the duration of antiglaucomatous therapy before trabeculectomy was evaluated. IOP readings were analyzed before and 1 day, 1, and 2 years after trabeculectomy. Statistical evaluation was performed by Mann and Whitney's U-test.


RESULTS
Patients with PEX showed a significant higher maximum IOP and a significant shorter duration of antiglaucomatous therapy before trabeculectomy. Both groups showed no significant differences in IOP before and after trabeculectomy. In the group with PEX a tendency to a lower IOP was found 1 year (p(U) = 0.13) and 2 years (p(U) = 0.16) after trabeculectomy. There was no significant difference in antiglaucomatous therapy after trabeculectomy.


CONCLUSIONS
This study did not find a reduced IOP lowering effect of trabeculectomy in eyes with PEX in comparison to eyes with POAG over time.
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D000368:Aged; D002908:Chronic Disease; D017889:Exfoliation Syndrome / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors; D014130:Trabeculectomy / Q000009:adverse effects / Q000706:statistics & numerical data; D016896:Treatment Outcome