Isoferulic acid as active principle from the rhizoma of Cimicifuga dahurica to lower plasma glucose in diabetic rats.
Isoferulic acid extracted from the rhizome of Cimicifuga dahurica Maxim. (Ranunculaceae) has been determined to have in vivo antihyperglycemic activity. An antihyperglycemic action of isoferulic acid in spontaneously diabetic rats, similar to type I diabetes, is presented.
Liu
I M
IM
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, R.O.C.
Chi
T C
TC
Hsu
F L
FL
Chen
C F
CF
Cheng
J T
JT
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002934:Cinnamates / Q000302:isolation & purification / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D002934:Cinnamates; D007004:Hypoglycemic Agents; C008180:isoferulic acid