title: Seprafilm-induced peritoneal inflammation: a previously unknown complication. Report of a case.
abstract: BACKGROUND
  Various substances and agents have been evaluated to prevent postoperative adhesion formation. Recently a sodium hyaluronate-based bioresorbable membrane was introduced with promising clinical results. Its application was regarded as safe and efficient.
  
  
  METHODS
  We present the first reported case of a severe inflammatory reaction to a bioresorbable membrane and give a review of the related literature.
  
  
  CONCLUSIONS
  Bioresorbable membranes are increasingly used by general surgeons and gynecologists to reduce postoperative adhesion formation. Bioresorbable membranes may produce extensive inflammatory reactions.
authors.affiliation: Department of General Surgery, Mayo Clinic Jacksonville, Florida 32224, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Klingler
authors.forename: N R
authors.initials: NR
authors.lastname: Floch
authors.forename: M H
authors.initials: MH
authors.lastname: Seelig
authors.forename: S A
authors.initials: SA
authors.lastname: Branton
authors.forename: J T
authors.initials: JT
authors.lastname: Wolfe
authors.forename: P P
authors.initials: PP
authors.lastname: Metzger
mesh_terms: D020341:Absorbable Implants / Q000009:adverse effects*; D000368:Aged; D001672:Biocompatible Materials / Q000009:adverse effects*; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007081:Ileostomy; D008297:Male; D008567:Membranes, Artificial; D010538:Peritonitis / Q000209:etiology*; D011183:Postoperative Complications / Q000517:prevention & control / Q000601:surgery; D012007:Rectum / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control / Q000601:surgery
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid