Relapsing acute pancreatitis induced by re-exposure to the cholesterol lowering agent bezafibrate.
We report a 75-yr-old patient, who presented three times with acute pancreatitis, accompanied by high temperature, shock, and multiorgan involvement and associated each time with exposure to the cholesterol lowering agent bezafibrate. Extensive workup excluded other possible causes for recurrent pancreatitis in this patient, further supporting bezafibrate as the cause of the patient's acute illness. Based on the short time elapsing between rechallenge and development of manifestations and the specific features of the attacks, we proposed hypersensitivity to bezafibrate as the underlying mechanism. The present report includes, for the first time, bezafibrate among definite causes of acute pancreatitis.
Gang
N
N
Department of Medicine F, Sheba Medical Center, Tel-Hashomer, Israel.
Langevitz
P
P
Livneh
A
A
D000208:Acute Disease; D000368:Aged; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001629:Bezafibrate / Q000008:administration & dosage / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D009102:Multiple Organ Failure / Q000139:chemically induced / Q000175:diagnosis; D010195:Pancreatitis / Q000139:chemically induced* / Q000175:diagnosis; D012008:Recurrence
D000924:Anticholesteremic Agents; D001629:Bezafibrate