Distribution of sensory properties among axotomized cutaneous C-fibres in adult rats.
A few hours after peripheral axons of cutaneous afferent neurons have been transected, some of their novel endings become excitable by physical or chemical stimuli. It has been assumed that these axon endings preferentially respond to those stimuli which have excited their previous receptive endings. We studied the prevalence of sensory properties among 784 unmyelinated sural nerve fibres which had been axotomized 2-24 h before, by applying mechanical and thermal forces to the nerve lesion site. Among 126 responding C-fibres, the majority was unimodal, responding exclusively to mechanical (31%), cold (23%) or heat (18%) stimuli. The remainder were either mechano-heat sensitive (10%), mechano-cold sensitive (6%) or heat and cold sensitive (12%). The distribution of sensory properties among acutely axotomized sural nerve C-fibres is therefore largely similar to the recently published distribution of receptor types among intact sural nerve C-fibre afferents. Thus, the hypothesis that responses of axotomized afferent fibres reflect their original receptive properties is corroborated. Knowledge of underlying transduction mechanisms may lead to specific pharmacological tools for suppression of ectopic discharges in unmyelinated axotomized afferents, which probably contribute to neuropathic pain states.
Michaelis
M
M
Physiologisches Institut, Christian-Albrechts-Universität, Kiel, Germany. m.michaelis@physiologie.uni-kiel.de
Blenk
K H
KH
Vogel
C
C
Jänig
W
W
D000367:Age Factors; D000818:Animals; D019771:Axotomy; D003080:Cold Temperature; D004594:Electrophysiology; D006358:Hot Temperature; D009412:Nerve Fibers / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009431:Neural Conduction / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology* / Q000648:ultrastructure; D010146:Pain / Q000503:physiopathology; D010292:Paresthesia / Q000503:physiopathology; D010812:Physical Stimulation; D051381:Rats; D012867:Skin / Q000294:innervation*; D013497:Sural Nerve / Q000166:cytology / Q000502:physiology*