The effect of liquid crystalline structure on chlorhexidine diacetate release.
The aim of this study was to examine different liquid crystalline preparations containing chlorhexidine diacetate and to find connection between their structure and the kinetic of drug release. Nonionic surfactant, Synperonic A7 (PEG(7)-C(13-15)) was selected for the preparation of the examined liquid crystalline systems. Mixtures of different ratios of Synperonic A7 and water were produced. By increasing the water content of the systems, lamellar and hexagonal liquid crystal structures were observed. For the analysis of the prepared liquid crystalline systems polarising microscopy, rheology study, differential scanning calorimetry and dynamic swelling tests were carried out. The chlorhexidine diacetate release was examined by Franz-type vertical diffusion cell apparatus. The chlorhexidine diacetate release from hexagonal liquid crystalline preparations was characterised by zero-order release kinetics, while the drug release from lamellar liquid crystalline systems was described by anomalous (non-Fickian) transport. The results indicate that the drug release kinetic is strongly dependent on the liquid crystalline structure.
Farkas
E
E
Pharmaceutical Institute, Semmelweis University of Medicine, 7 Hogyes E. Street, H-1092, Budapest, Hungary.
Zelkó
R
R
Németh
Z
Z
Pálinkás
J
J
Marton
S
S
Rácz
I
I
D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002710:Chlorhexidine / Q000008:administration & dosage* / Q000737:chemistry; D003460:Crystallization; D004058:Diffusion; D007700:Kinetics; D008859:Microscopy, Polarization; D012212:Rheology; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents; D013816:Thermodynamics
D000891:Anti-Infective Agents, Local; D013501:Surface-Active Agents; D002710:Chlorhexidine