title: Alpha/beta hydrolase fold enzymes: the family keeps growing.
abstract: The alpha/beta hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family.
authors.affiliation: Laboratory of Biophysical Chemistry, BIOSON Research Institute, University of Groningen, Groningen, 9747 AG, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Nardini
authors.forename: B W
authors.initials: BW
authors.lastname: Dijkstra
mesh_terms: D001224:Aspartic Acid / Q000737:chemistry; D001665:Binding Sites; D018698:Glutamic Acid / Q000737:chemistry; D006867:Hydrolases / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding
chemical_list: D001224:Aspartic Acid; D018698:Glutamic Acid; D006867:Hydrolases