title: Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients.
abstract: Plasma sialyltransferase activity measured by incorporation of cytidine 5;-phospho[14C]acetylneuraminic acid (CMP-NeuAc) into asialofetuin was twofold higher in patients with documented atherosclerosis than in healthy donors. Kinetic studies showed that the enzyme affinity for CMP-NeuAc is the same in donors and patients. Low activity of plasma sialyltransferase in donors may be due to low blood content of this enzyme.
authors.affiliation: Institute of Experimental Cardiology, Cardiology Research Center, Russian Ministry of Health, Moscow, 121552, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Gracheva
authors.forename: N K
authors.initials: NK
authors.lastname: Golovanova
authors.forename: M V
authors.initials: MV
authors.lastname: Ezhov
authors.forename: P P
authors.initials: PP
authors.lastname: Malyshev
authors.forename: V V
authors.initials: VV
authors.lastname: Kukharchuk
authors.forename: N V
authors.initials: NV
authors.lastname: Prokazova
mesh_terms: D001161:Arteriosclerosis / Q000097:blood / Q000201:enzymology*; D016022:Case-Control Studies; D003568:Cytidine Monophosphate / Q000378:metabolism; D006801:Humans; D012799:Sialyltransferases / Q000097:blood*
chemical_list: D012799:Sialyltransferases; D003568:Cytidine Monophosphate