[Effect of some metabolites on the synthesis of nitric oxide by rat peritoneal macrophages].
The peculiarities of some purine and energetic metabolites effect on the nitric oxide synthesis by vaccine BCG activated rat peritoneal macrophages has been studied. It was shown, that the glutamine and hypoxanthine caused essential increased of the nitrite level in the cell culture medium, but glutamic acid, adenosine, inosine and ATP did change these parameter. The mechanisms of studied compounds effect on the macrophages Ca(2+)-independent inducible NO-synthase activity are being discussed.
Smerdova
L N
LN
Kishko
T O
TO
Parshikov
A V
AV
Dmitrenko
N P
NP
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D002118:Calcium / Q000378:metabolism; D003470:Culture Media; D018698:Glutamic Acid / Q000494:pharmacology; D007288:Inosine / Q000494:pharmacology; D008262:Macrophage Activation; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D051381:Rats
D001500:BCG Vaccine; D003470:Culture Media; D009569:Nitric Oxide; D018698:Glutamic Acid; D007288:Inosine; D000255:Adenosine Triphosphate; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D000241:Adenosine; D002118:Calcium