Clinical and magnetic resonance imaging findings in chronic sensory ganglionopathies.
Twenty-two of 29 patients with chronic sensory ataxic neuropathy showed T2-weighted magnetic resonance imaging high signal intensity in the posterior columns of the cervical spine. T2 changes reflected the degeneration of central sensory projections and localized the disease process to T-shaped dorsal root ganglion neurons. No similar abnormalities were found in sensory and sensorimotor length-dependent axonal neuropathy patients. Spinal cord magnetic resonance imaging is a useful tool to support the clinical diagnosis of primary ganglionopathy.
Lauria
G
G
Department of Neurology, National Neurological Institute C Besta, Milan, Italy.
Pareyson
D
D
Grisoli
M
M
Sghirlanzoni
A
A
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D001259:Ataxia / Q000473:pathology* / Q000503:physiopathology*; D002648:Child; D005260:Female; D009477:Hereditary Sensory and Autonomic Neuropathies / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000473:pathology