title: Reperfusion pattern of the immature femoral head after critical ischemia: a microsphere study in pigs.
abstract: The topographic reperfusion pattern of the femoral head after critical ischemia has not yet been investigated. We determined the blood flow of the porcine hip regions with the femoral head epiphysis divided into 24 subregions by the tracer microsphere technique. Blood flow was measured under steady-state conditions, at the end of a 6-hour increase in intracapsular hip joint pressure to 250 mm Hg, and 4 hours after release of the joint tamponade. Total femoral head epiphyseal blood flow decreased with ischemia and regained steady-state perfusion after tamponade. The reperfusion pattern of the femoral head epiphysis appeared identical with that of the steady state before ischemia. However, 2 of the 11 experimental epiphyses remained ischemic in the reperfusion phase. We conclude that hip joint tamponade above the arterial pressure level for 6 hours causes global ischemia in the femoral head epiphysis in the immature pig, without regional differences in reperfusion, and that reperfusion occurs at a level like that of the steady state before ischemia.
authors.affiliation: Institute of Experimental Clinical Research, Department of Orthopedics, University of Aarhus, Denmark. wolfdrescher@hotmail.com
authors.forename: W
authors.initials: W
authors.lastname: Drescher
authors.forename: T
authors.initials: T
authors.lastname: Schneider
authors.forename: C
authors.initials: C
authors.lastname: Becker
authors.forename: L
authors.initials: L
authors.lastname: Hobolth
authors.forename: W
authors.initials: W
authors.lastname: Rüther
authors.forename: C
authors.initials: C
authors.lastname: Bünger
authors.forename: E S
authors.initials: ES
authors.lastname: Hansen
mesh_terms: D000367:Age Factors; D000818:Animals; D001706:Biopsy; D001783:Blood Flow Velocity; D001794:Blood Pressure; D004195:Disease Models, Animal; D005260:Female; D005263:Femoral Artery / Q000503:physiopathology; D005270:Femur Head / Q000098:blood supply* / Q000254:growth & development*; D006439:Hemodynamics; D008297:Male; D008863:Microspheres; D011849:Radioactive Tracers; D011897:Random Allocation; D015427:Reperfusion Injury / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013552:Swine; D013997:Time Factors
chemical_list: D011849:Radioactive Tracers