title: Macronutrient diet intake of the lethal yellow agouti (Ay/a) mouse.
abstract: To examine the effect of chronic endogenous melanocortin receptor (MC-R) antagonism on macronutrient diet selection, Ay/a mice that ectopically overexpress the MC-R antagonist, agouti, were fed a three-choice macronutrient diet of pure fat, carbohydrate, and protein. Ay/a mice gained more weight and consumed a greater proportion of their daily intake from fat and less from carbohydrate than wild-type littermates did. The increased fat preference was present immediately, and persisted throughout the 7-week long experiment. Protein intake was greater for Ay/a mice; however, the proportion of protein intake to total intake was similar between mouse types. Ovarian fat pads of Ay/a mice comprised a greater percentage of total body weight that that from wild-type littermates. These results suggest that endogenous inhibition of MC-Rs mediate the increased fat intake in growing mice.
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA.
authors.forename: F H
authors.initials: FH
authors.lastname: Koegler
authors.forename: A O
authors.initials: AO
authors.lastname: Schaffhauser
authors.forename: R L
authors.initials: RL
authors.lastname: Mynatt
authors.forename: D A
authors.initials: DA
authors.lastname: York
authors.forename: G A
authors.initials: GA
authors.lastname: Bray
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D004032:Diet; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D004435:Eating / Q000235:genetics*; D005260:Female; D005518:Food Preferences / Q000502:physiology; D006200:Hair Color / Q000235:genetics*; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000235:genetics*; D011979:Receptors, Pituitary Hormone / Q000235:genetics*
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D011979:Receptors, Pituitary Hormone; C029446:MSH receptor; D009074:Melanocyte-Stimulating Hormones