Sensory eye irritation in humans exposed to mixtures of volatile organic compounds.
Eight subjects participated in a controlled eyes-only exposure study of human sensory irritation in ocular mucosal tissue. The authors investigated dose-response properties and the additive effects of three mixtures of volatile organic compounds. The dose-response relationships for these mixtures showed increases in response intensity as concentration increased. Replication of exposure did not result in significantly different dose- response relationships. Moreover, the result implied that components of the three mixtures interacted additively to produce ocular irritation, a result referred to as simple agonism. Finally, the authors addressed the comparability of two methods to measure sensory irritation intensity (visual analogue scale and a comparative scale). The results indicated that the two rating methods produced highly comparable results.
Hempel-Jørgensen
A
A
Department of Environmental and Occupational Medicine, University of Aarhus, Denmark.
Kjaergaard
S K
SK
Mølhave
L
L
Hudnell
K H
KH
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects*; D005260:Female; D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009930:Organic Chemicals / Q000008:administration & dosage / Q000009:adverse effects*; D010147:Pain Measurement; D012677:Sensation; D014835:Volatilization
D000393:Air Pollutants; D007509:Irritants; D009930:Organic Chemicals