title: Recovery of severe sciatica.
abstract: METHODS
  A prospective study of patients with acute severe sciatica.
  
  
  OBJECTIVE
  To 1) describe the characteristics of patients with acute severe sciatica and the agreement among different diagnostic tests, 2) describe overall recovery during 1 year in terms of perceived disability, and pain, and 3) explore acute-phase predictors of failure to recover at 1 year.
  
  
  BACKGROUND
  The development of imaging techniques has been very impressive during recent decades. However, different authors have highlighted the prevalence of abnormal images among asymptomatic subjects. These findings increase the difficulty of interpreting the results from the diagnostic techniques used with each individual patient. Furthermore, other clinical and biopsychosocial variables need to be explored for their associations with recovery or failure to recover. This study aimed to explore those associations.
  
  
  METHODS
  Consecutive patients admitted to the hospital for conservative management of severe acute sciatica were eligible for inclusion in the study. Patients were evaluated at admission, discharge, and 3, 6, and 12 months. All the visits included a standardized clinical examination and the completion of questionnaires that included items on demographics, pain, perceived disability, and quality of life. Imaging and blood samples were collected at the first visit, and an electromyogram was taken for sciatica lasting at least 3 weeks.
  
  
  RESULTS
  The study included 82 consecutive patients (66% men) with a mean age of 43 +/- 10.3 years. The mean intensity of pain, on a visual analog scale of 0 to 100 (VAS) at Visit 1, was 73. The straight leg raising test was positive in 78% of the patients, with a mean value of 59 degrees +/- 18 degrees. The contralateral straight leg raising test was positive in 20% of the patients. Imaging was positive for disc herniation in 74% and electromyogram was positive in 62% of cases. These two diagnostic tests showed a good to excellent total agreement (58-87%) with the straight leg raising tests and the presence of radiating pain below the knee. The recovery of clinical symptoms and signs was observed mainly within the first 3 months. However, clinical recovery and perceived recovery was not complete in most cases.
  
  
  CONCLUSIONS
  In most cases, there was good to excellent agreement among the different diagnostic tests. None of the tests was predictive of recovery. The presence of blood antibodies against 3'LM1 (IgM + IgG) and GD1a (IgM) was significantly associated (P < 0.023) with neurologic symptoms and signs. However, the meaning of these antibodies remains unclear. Only a minority of the patients (29%) had fully recovered after 12 months. Within the 1-year follow-up, one third of the patients had surgery.
authors.affiliation: Hôpital Cantonal, Fribourg, Switzerland. balaguef@etatfr.ch
authors.forename: F
authors.initials: F
authors.lastname: Balagué
authors.forename: M
authors.initials: M
authors.lastname: Nordin
authors.forename: A
authors.initials: A
authors.lastname: Sheikhzadeh
authors.forename: A C
authors.initials: AC
authors.lastname: Echegoyen
authors.forename: H
authors.initials: H
authors.lastname: Brisby
authors.forename: H M
authors.initials: HM
authors.lastname: Hoogewoud
authors.forename: P
authors.initials: P
authors.lastname: Fredman
authors.forename: M L
authors.initials: ML
authors.lastname: Skovron
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D020127:Recovery of Function; D012585:Sciatica / Q000503:physiopathology*