title: Degenerative lumbar listhesis and bone mineral density in elderly women. The study of osteoporotic fractures.
abstract: METHODS
  A cross-sectional and prospective study.
  
  
  OBJECTIVE
  To investigate the association between lumbar listhesis in elderly white women and bone mineral density at the spine, hip, radius, and calcaneus.
  
  
  BACKGROUND
  Several types of degenerative spinal changes have been found to be associated with high bone mineral density at the spine and other body sites.
  
  
  METHODS
  Lateral radiographs of the lumbar spine for 1400 elderly women enrolled in the Study of Osteoporotic Fractures were digitized. Listhesis (antero and retro) was assessed at L3-L4, L4-L5, and L5-S1. Bone mineral density was measured at the spine, hip, calcaneus, and the distal and proximal radius.
  
  
  RESULTS
  After adjusting the data for age and body mass index, retrolisthesis at L3-L4, L4-L5, and L5-S1 was associated with mean spinal bone mineral density levels that were 9% to 13% higher compared with those levels in women with no listhesis (P < 0.0001). In addition, bone mineral density at the hip and appendicular sites increased from 4% to 9%. The mean lumbar spinal bone mineral density of women with anterolisthesis at L3-L4 was 12% higher (P < 0.05) than that of women with no listhesis; it was the same for both groups at L4-L5 and was 7% lower (P < 0.005) at L5-S1. At L5-S1 the bone mineral density level at the hip and appendicular sites was also lower among the women with anterolisthesis at that level.
  
  
  CONCLUSIONS
  This study suggests that retrolisthesis, like other spinal degenerative diseases, is associated with increased spinal bone mineral density. Anterolisthesis, however, may involve a different etiology, because its association with bone mineral density varies by spinal level.
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA. mvogt@uoi.upmc.edu
authors.forename: M T
authors.initials: MT
authors.lastname: Vogt
authors.forename: D A
authors.initials: DA
authors.lastname: Rubin
authors.forename: R
authors.initials: R
authors.lastname: San Valentin
authors.forename: L
authors.initials: L
authors.lastname: Palermo
authors.forename: J D
authors.initials: JD
authors.lastname: Kang
authors.forename: W F
authors.initials: WF
authors.lastname: Donaldson
authors.forename: M
authors.initials: M
authors.lastname: Nevitt
authors.forename: J A
authors.initials: JA
authors.lastname: Cauley
mesh_terms: D000368:Aged; D015519:Bone Density / Q000502:physiology*; D003430:Cross-Sectional Studies; D005260:Female; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D011446:Prospective Studies; D011859:Radiography; D013168:Spondylolisthesis / Q000000981:diagnostic imaging* / Q000503:physiopathology*