[The effect of losartan on cardiac rhythm variability in patients with arterial hypertension].
Our objective in this study was gaining insights into changes of certain indices for variability of the heart's rhythm (VHR) in the time-related course of therapy with lozartan (cozaar, MSD). A total of nine patients with stage II arterial hypertension were examined. VHR indices were studied with the aid of the computer electrocardiograph Cardiolab-200. The following items were assessed before and after treatment: coefficient of variation of RR-intervals duration in ECG, relative power of spectrum in the region (domains) of very low (VLF, %), Low (LF, %), and high (HF, %) frequencies, and low-to-high frequency region powers ratio as an index of sympathovagal balance (LF/HF). The obtained results revealed a hypotensive effect of lozartan at day 21 of the start of therapy. The therapy treatments administered tended to increase general power of the variation spectrum in patients with a baseline low variability, its rise being accompanied by simultaneous humoral mechanisms of regulation-related drop in the domain power. Predominance of sympathetic link of VHR control over the parasympathetic one before and after lozartan therapy appear to be caused by insufficient duration of its course together with an increase in the sympathetic link at the expense of suppression of the humoral link.
Kamenskaia
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D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004452:Echocardiography / Q000187:drug effects; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D019808:Losartan / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D012074:Remission Induction
D000959:Antihypertensive Agents; D019808:Losartan