title: Synthesis of combinatorial libraries of 3,4,5-trisubstituted 2(5H)-furanones. Part One: Construction of a sub-library of halogenated 5-alkoxy-2(5H)-furanones.
abstract: Starting from furfural, 5-hydroxy-3,4-dihalo-2(5H)-furanones and 5-hydroxy-4 chloro-2(5H)-furanone were converted into 3 sublibraries of halogenated 5-alkoxy-2(5H)-furanones. The reactivity of 24 halogenated 5-alkoxy2(5H)-furanones was chemically evaluated by using 4 selected amines for subsequent reactions. The biological evaluation of the pseudo-muco halogen esters resulted in the discovery of a lead structure with potent anti-cancer activity.
authors.affiliation: Pharmaceutical Sciences Research Institute, Aston University, Birmingham, England. e.lattmann@aston.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Lattmann
authors.forename: D C
authors.initials: DC
authors.lastname: Billington
authors.forename: C A
authors.initials: CA
authors.lastname: Langley
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006219:Halogens / Q000737:chemistry*
chemical_list: D005663:Furans; D006219:Halogens