title: Central nervous system impairment in diabetic patients.
abstract: The aims of this study were to investigate the function of the central motor control system in interaction with the vestibular and auditory systems (measured by H-reflex changes in response to vestibular and acoustic stimulations) in diabetics without clinical data for CNS impairment, in order to establish whether the disease affects these CNS mechanisms; and to assess this approach in detecting subclinical CNS diabetic pathology. The results show the same mode of change of H-reflex amplitude in response to acoustic and vestibular stimulations in diabetics as in normal subjects. However the degree of facilitation and inhibition was significantly (p < 0.001) higher in diabetics which indicates subclinical CNS dysfunction. Therefore it was concluded that the test is useful in early diagnosis of the diabetic CNS impairment.
authors.affiliation: University Hospital of Neurology and Psychiatry, III Neurological Clinic, Sofia, Bulgaria.
authors.forename: O I
authors.initials: OI
authors.lastname: Kolev
authors.forename: I
authors.initials: I
authors.lastname: Milanov
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D002150:Caloric Tests; D016022:Case-Control Studies; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000503:physiopathology; D003056:Cochlear Nerve / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003929:Diabetic Neuropathies / Q000175:diagnosis* / Q000503:physiopathology; D004576:Electromyography; D004584:Electronystagmography; D005260:Female; D006181:H-Reflex / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000503:physiopathology; D011930:Reaction Time; D014725:Vestibular Nerve / Q000503:physiopathology*