Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling.
Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca(2+) signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca(2+) signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.
Yermolaieva
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O
Department of Physiology, University of Iowa, Bowen Science Building, Iowa City, IA 52242, USA.
Brot
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N
Weissbach
H
H
Heinemann
S H
SH
Hoshi
T
T
D000818:Animals; D001921:Brain / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects*; D002454:Cell Differentiation; D016257:Fura-2 / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism; D051150:Methionine Sulfoxide Reductases; D020932:Nerve Growth Factor / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology; D010088:Oxidoreductases / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D016716:PC12 Cells; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D009599:Nitroprusside; D009569:Nitric Oxide; D006632:Histamine; D020932:Nerve Growth Factor; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D011188:Potassium; D010100:Oxygen; D016257:Fura-2