Diversity in protein recognition by PTB domains.
Phosphotyrosine-binding (PTB) domains were originally identified as modular domains that recognize phosphorylated Asn-Pro-Xxx-p Tyr-containing proteins. Recent binding and structural studies of PTB domain complexes with target peptides have revealed a number of deviations from the previously described mode of interaction, with respect to both the sequences of possible targets and their structures within the complexes. This diversity of recognition by PTB domains extends and strengthens our general understanding of modular binding domain recognition.
Forman-Kay
J D
JD
Department of Biochemistry, Structural Biology and Biochemistry Program, Research Institute, Hospital for Sick Children, University of Toronto, Toronto, M5G 1X8, M5S 1A8, Canada. forman@sickkids.on.ca
Pawson
T
T
D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism*; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D011506:Proteins; D019000:Phosphotyrosine