title: Natural history of rheumatoid arthritis of the cervical spine.
abstract: This article reviews the natural history of rheumatoid arthritis involving the cervical spine with special attention given to predictors of paralysis. Understanding the natural history of rheumatoid arthritis of the cervical spine is necessary to determine the benefit of various interventions. The primary treatment goal for cervical instability is prevention of irreversible neurologic injury. The natural history of rheumatoid arthritis for a period of 10 years or more is one of significant disease progression. The natural history of cervical instability in patients with rheumatoid arthritis is more variable, with only some patients having a neurologic deficit develop. Recent studies support prophylactic stabilization of the rheumatoid cervical spine to prevent paralysis in high risk patients. However, proponents for prophylactic arthrodesis must acknowledge that not all cervical instability in rheumatoid arthritis progresses to neurologic deficit, and surgical intervention in patients with rheumatoid arthritis incurs added morbidity and mortality. Identifying the risk factors for progression of cervical instability is the first step in eliminating morbidity and mortality from spinal cord and brain stem compression. Surgical stabilization is indicated not only for those patients with paralysis, but for the subgroups of patients with cervical rheumatoid disease who are at risk for spinal cord and brain stem compression. The posterior atlantodental interval is the most reliable screening tool and predictor of progressive neurologic deficit.
authors.affiliation: Emory Spine Center, Emory University School of Medicine, Atlanta, GA 30033, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Dreyer
authors.forename: S D
authors.initials: SD
authors.lastname: Boden
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D001268:Atlanto-Axial Joint / Q000503:physiopathology; D001927:Brain Diseases / Q000517:prevention & control; D001933:Brain Stem / Q000503:physiopathology; D002574:Cervical Vertebrae / Q000503:physiopathology* / Q000601:surgery; D018450:Disease Progression; D005544:Forecasting; D006801:Humans; D007593:Joint Instability / Q000503:physiopathology / Q000601:surgery; D009809:Odontoid Process / Q000503:physiopathology; D010243:Paralysis / Q000209:etiology / Q000517:prevention & control; D012307:Risk Factors; D013117:Spinal Cord Compression / Q000517:prevention & control; D013122:Spinal Diseases / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D013123:Spinal Fusion