title: A comparison of enalapril 20 mg once daily versus 10 mg twice daily in terms of blood pressure lowering and patient compliance.
abstract: OBJECTIVE
  To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.
  
  
  METHODS
  Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.
  
  
  METHODS
  General practices in the greater Belfast and Lisburn area in Northern Ireland.
  
  
  METHODS
  Twenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.
  
  
  METHODS
  Reduction in blood pressure and estimation of patient compliance.
  
  
  RESULTS
  Patient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.
  
  
  CONCLUSIONS
  Enalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance.
authors.affiliation: Department of Therapeutics and Pharmacology, The Queen's University of Belfast, UK.
authors.forename: B
authors.initials: B
authors.lastname: Girvin
authors.forename: B J
authors.initials: BJ
authors.lastname: McDermott
authors.forename: G D
authors.initials: GD
authors.lastname: Johnston
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D010349:Patient Compliance; D011187:Posture / Q000502:physiology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril