[The oxidative metabolic activity of the polymorphonuclear neutrophilic leukocytes in patients infected with the human immunodeficiency virus].
BACKGROUND
Contradictory results on oxidative burst activity in HIV infection have been reported in the literature.


METHODS
Neutrophil oxidative metabolism was evaluated in 160 HIV-infected patients, by measuring the intracellular production of rhodamine.


RESULTS
Neutrophil oxidative metabolism was decreased. This impairment was related to viral load, CD4+ lymphocyte counts, neutrophil counts and therapy.


CONCLUSIONS
In HIV-infected patients, neutrophil oxidative metabolic activity decreases with disease progression. This may contribute to secondary opportunistic infections.
Diz Dios
P
P
Facultad de Medicina y Odontología, Universidad de Santiago de Compostela, Vigo. pdiz@usc.es
Ocampo Hermida
A
A
Rayo Llerena
N
N
Otero Varela
I
I
Iglesias Martín
I
I
Martínez Vázquez
C
C
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D005434:Flow Cytometry / Q000706:statistics & numerical data; D015658:HIV Infections / Q000097:blood*; D015497:HIV-1; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction; D011897:Random Allocation