title: Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals.
abstract: The antitussive activity of Adhatoda vasica (AV) extract was evaluated in anaesthetized guinea pigs and rabbits and in unanaesthetized guinea pigs. AV was shown to have a good antitussive activity. Intravenously, it was 1/20-1/40 as active as codeine on mechanically and electrically induced coughing in rabbits and guinea-pigs. After oral administration to the guinea-pig the antitussive activity of AV was similar to codeine against coughing induced by irritant aerosols.
authors.affiliation: Department of Pharmacology and Toxicology, Hindustan Antibiotics Ltd., Pimpri, Pune, India.
authors.forename: J N
authors.initials: JN
authors.lastname: Dhuley
mesh_terms: D000818:Animals; D000996:Antitussive Agents / Q000627:therapeutic use*; D003371:Cough / Q000188:drug therapy* / Q000209:etiology; D004558:Electric Stimulation; D006168:Guinea Pigs; D007509:Irritants / Q000008:administration & dosage; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D011817:Rabbits; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D000996:Antitussive Agents; D007509:Irritants; D010936:Plant Extracts