Recovery of spermatogenesis and successful conception after bone marrow transplant for acute leukaemia: case report.
A case is presented of a young adult male diagnosed with acute myeloid leukaemia who was treated with busulphan and cyclophosphamide, but not total body irradiation, with subsequent bone marrow transplantation. After surviving for 5 years, he and his wife experienced a period of infertility. Interestingly, the problem was found to be with the female partner and the man's sperm evaluation seemed normal. A successful pregnancy ensued following the surgical removal of a large endometrioma and treating a luteal phase deficiency. Though this may be the fifth case of proven parentage in cases of bone marrow conditioning and bone marrow transplantation in a male for control of leukaemia, we believe it is the first documented case showing a normal semen analysis despite treatment. Further studies are needed to see if chemical conditioning with busulphan and cyclophosphamide preserve the chances of sperm production better than total body irradiation.
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The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics And Gynecology, Camden, NJ, USA.
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D000328:Adult; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004715:Endometriosis / Q000150:complications / Q000601:surgery; D005260:Female; D005298:Fertility; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008183:Luteal Phase / Q000502:physiology; D008297:Male; D011247:Pregnancy; D013091:Spermatogenesis; D019172:Transplantation Conditioning
D003520:Cyclophosphamide; D002066:Busulfan