Role of nitric oxide in cancer biology.
The role of nitric oxide (NO) in tumorigenesis is multifactorial. NO can participate in the complicated process of carcinogenesis by mediating DNA damage in early phases of tumorigenesis, as well as support tumor progression through the induction of angiogenesis and suppression of the immune response. This paper addresses the effects of NO on transcriptional regulation following DNA damage and cyclooxygenase expression in the multistep process of tumorigenesis.
Moochhala
S
S
Applied Physiology Branch, Defence Medical Research Institute, National University of Singapore, Singapore. nmiv19@nus.edu.sg
Rajnakova
A
A
D000818:Animals; D004249:DNA Damage; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009569:Nitric Oxide / Q000502:physiology*
D009569:Nitric Oxide