title: Low-flow anesthesia and reduced animal size increase carboxyhemoglobin levels in swine during desflurane and isoflurane breakdown in dried soda lime.
abstract: After institutional approval, we studied the effect of animal size, anesthetic concentration, and fresh gas flow (FGF) rate on inspired carbon monoxide (CO) and carboxyhemoglobin (COHb) during anesthesia in swine, using soda lime previously dried to 1 +/- 0.1% water content. To ascertain the effect of anesthesia, eight adult pigs were anesthetized with either 1 minimum alveolar anesthetic concentration (MAC) desflurane or isoflurane and, to characterize the effect of the FGF rate, it was doubled in four pigs. To determine the effect of animal size, four small and four large pigs received 1 MAC desflurane or isoflurane, and to determine the effect of the anesthetic concentration, a group of four swine was exposed to 0.5 MAC. CO and COHb concentrations were larger with desflurane (5500 +/- 980 ppm and 57.90% +/- 0.50%, respectively) than with isoflurane (800 ppm and 17.8% +/- 2.14%, respectively), especially in the small animals. Increasing the FGF rate significantly reduced peak CO and COHb concentrations resulting from both anesthetics; however, when each anesthetic was reduced to 0.5 MAC, the concentrations obtained were similar. We conclude that CO intoxication is more severe with desflurane than with isoflurane, that small animals are at higher risk for CO poisoning, and that low FGF can increase COHb concentrations.
  
  
  CONCLUSIONS
  The present study shows that the use of desflurane with desiccated carbon dioxide absorbents in pediatric anesthesia can produce a dangerous carbon dioxide intoxication, especially with low-flow anesthesia.
authors.affiliation: Department of Anesthesiology, Hospital Juan Canalejo, La Coruña, Spain. cesarbonome@jet.es
authors.forename: C
authors.initials: C
authors.lastname: Bonome
authors.forename: J
authors.initials: J
authors.lastname: Belda
authors.forename: F
authors.initials: F
authors.lastname: Alvarez-Refojo
authors.forename: M
authors.initials: M
authors.lastname: Soro
authors.forename: C
authors.initials: C
authors.lastname: Fernández-Goti
authors.forename: A
authors.initials: A
authors.lastname: Cortés
mesh_terms: D000042:Absorption; D000388:Air; D000764:Anesthesia, Closed-Circuit / Q000295:instrumentation / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D000818:Animals; D001824:Body Constitution; D001835:Body Weight; D017610:Calcium Compounds / Q000737:chemistry*; D002248:Carbon Monoxide / Q000008:administration & dosage / Q000737:chemistry; D002249:Carbon Monoxide Poisoning / Q000209:etiology; D002263:Carboxyhemoglobin / Q000032:analysis*; D000077335:Desflurane; D001239:Inhalation; D007530:Isoflurane / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D012212:Rheology; D012307:Risk Factors; D012972:Sodium Hydroxide / Q000737:chemistry*; D013552:Swine
chemical_list: D018685:Anesthetics, Inhalation; D017610:Calcium Compounds; D010087:Oxides; C004569:soda lime; D012972:Sodium Hydroxide; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D000077335:Desflurane; D007530:Isoflurane