Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties.
A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary amino function is not essential for anticonvulsant activity in the semicarbazone series of compounds. Presumably these compounds could further act on glycine receptors.
Pandeya
S N
SN
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
Ponnilavarasan
I
I
Pandey
A
A
Lakhan
R
R
Stables
J P
JP
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003292:Convulsants; D004597:Electroshock; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010433:Pentylenetetrazole; D004856:Postural Balance / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013331:Strychnine
D000927:Anticonvulsants; D003292:Convulsants; D012664:Semicarbazones; D013331:Strychnine; D010433:Pentylenetetrazole