title: Acute renal failure in four cats treated with paromomycin.
abstract: Acute renal failure was diagnosed in 4 cats receiving paromomycin orally for treatment of infectious enteritis. All 4 cats responded to fluid therapy and recovered normal or near-normal renal function; however, 3 of the cats subsequently became deaf and developed cataracts. Toxicoses were attributed to a combination of an excessive dosage of paromomycin and absorption of the drug across injured intestinal mucosal epithelium. Pharmacokinetic studies are needed to further define the disposition of paromomycin after oral administration to cats.
authors.affiliation: Department of Anatomy, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Gookin
authors.forename: J E
authors.initials: JE
authors.lastname: Riviere
authors.forename: B C
authors.initials: BC
authors.lastname: Gilger
authors.forename: M G
authors.initials: MG
authors.lastname: Papich
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary*; D000563:Amebicides / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D002371:Cat Diseases / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D002386:Cataract / Q000139:chemically induced / Q000662:veterinary; D002415:Cats; D003457:Cryptosporidiosis / Q000188:drug therapy; D003458:Cryptosporidium / Q000187:drug effects; D003638:Deafness / Q000139:chemically induced / Q000662:veterinary; D004751:Enteritis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary; D007413:Intestinal Mucosa / Q000187:drug effects; D010303:Paromomycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D014244:Trichomonas / Q000187:drug effects; D014245:Trichomonas Infections / Q000188:drug therapy
chemical_list: D000563:Amebicides; D010303:Paromomycin