title: Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease.
abstract: Serotonergic dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). This association study explores whether the serotonin 6 receptor (5-HT6) polymorphism (C267T) is a susceptibility factor for AD. Statistical analysis showed a significant difference in the genotype and gene frequencies between the AD group and the normal controls (P = 0.006; and P = 0.023, respectively). These findings indicate that the 267C allele of the 5-HT6 gene is a risk factor for AD.
authors.affiliation: Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, ROC.
authors.forename: S J
authors.initials: SJ
authors.lastname: Tsai
authors.forename: H C
authors.initials: HC
authors.lastname: Liu
authors.forename: T Y
authors.initials: TY
authors.lastname: Liu
authors.forename: Y C
authors.initials: YC
authors.lastname: Wang
authors.forename: C J
authors.initials: CJ
authors.lastname: Hong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*
chemical_list: D011985:Receptors, Serotonin; C097216:serotonin 6 receptor