title: Lack of benefit of intravenous immune globulin in a murine model of group A streptococcal necrotizing fasciitis.
abstract: Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P<.05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P=.02), penicillin/clindamycin (P=.009), clindamycin/IVIG (P=.04), or all agents combined (P=.02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA. patel.robin@mayo.edu
authors.forename: R
authors.initials: R
authors.lastname: Patel
authors.forename: M S
authors.initials: MS
authors.lastname: Rouse
authors.forename: M V
authors.initials: MV
authors.lastname: Florez
authors.forename: K E
authors.initials: KE
authors.lastname: Piper
authors.forename: F R
authors.initials: FR
authors.lastname: Cockerill
authors.forename: W R
authors.initials: WR
authors.lastname: Wilson
authors.forename: J M
authors.initials: JM
authors.lastname: Steckelberg
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D019115:Fasciitis, Necrotizing / Q000188:drug therapy*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000627:therapeutic use*; D013297:Streptococcus pyogenes / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D016756:Immunoglobulins, Intravenous; D010406:Penicillins; D002981:Clindamycin