Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis and calcium phosphate crystallization in urine of patients with idiopathic calcium urolithiasis? An orientational study.
Uric acid (UA), a waste product of purine metabolism, may be involved in calcium phosphate crystallization and deposition. Rats, which develop nephrocalcinosis on high-fat or magnesium-deficient diets, and patients with idiopathic calcium urolithiasis have hyperproteinuria, especially of nonalbumin protein, and a shift toward elevated serum UA. In rats, an increase in UA precursors and renal UA suggests hypoxemia, which stimulates xanthine oxidase. In patients, a primary increase in renal xanthine oxidase would explain the low urine UA in the presence of an elevated serum concentration. For calcium phosphate deposition (rats) or incorporation into stones (humans) to occur, a crucial factor may be xanthine oxidase-mediated overproduction of free radical species and subsequent tissue damage. Another factor may be whether sufficient UA is synthesized to neutralize these free radicals. Allopurinol use, which inhibits xanthine oxidase and has long been favored for the treatment of idiopathic calcium urolithiasis, may not prevent stones, because it also diminishes the availability of UA. An investigation of the factors that control serum UA homeostasis may be rewarding in research into the etiology of idiopathic calcium urolithiasis.
Schwille
P O
PO
Department of Surgery, University of Erlangen, Germany.
Schmiedl
A
A
Manoharan
M
M
Wipplinger
J
J
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D003460:Crystallization; D004195:Disease Models, Animal; D006801:Humans; D009397:Nephrocalcinosis / Q000503:physiopathology*; D014527:Uric Acid / Q000378:metabolism*; D014545:Urinary Calculi / Q000652:urine*
D002130:Calcium Phosphates; D014527:Uric Acid; D002118:Calcium