Hypopigmentation of a papillary carcinoma arising in a black thyroid.
We report a case of an unpigmented papillary carcinoma arising in a black thyroid induced by minocycline. Black thyroid syndrome is an unusual pigmented change seen almost exclusively in patients on minocycline, apparently resulting from an oxidative interaction between thyroid peroxidase and the drug. Twenty-six cases have previously been reported in the English literature, nine of which described an associated thyroid neoplasm. Four of these nine neoplasms were described as pale or hypopigmented. The nature of the lesion against the background of pigmentation suggests diminished function of the thyroid peroxidase in this clonal population.
Thompson
A D
AD
Department of Pathology and Laboratory Medicine, University of Calgary and Foothills Medical Centre, Alberta, Canada.
Pasieka
J L
JL
Kneafsey
P
P
DiFrancesco
L M
LM
D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D008911:Minocycline / Q000009:adverse effects*; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D013959:Thyroid Diseases / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D013964:Thyroid Neoplasms / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy
D000900:Anti-Bacterial Agents; D008911:Minocycline