title: Fatal course of veno-occlusive disease of the liver (endophlebitis hepatica obliterans) in a preterm infant.
abstract: We describe the fatal course of a preterm infant of 34 weeks' gestation with veno-occlusive disease of the liver and refractory ascites. Despite aggressive medical management, the baby died twenty-two hours post partum because of cerebral haemorrhage before potentially life-saving organ transplantation could take place. At autopsy, paucity of lymphoid tissue in lymph nodes, thymus, spleen, and gastrointestinal tract were also seen. To our knowledge, this is the youngest infant with veno-occlusive disease of the liver reported in the literature.
authors.affiliation: Institute of Pathology, University of Heidelberg, Germany. Consolato_Sergi@med.uni-heidelberg.de
authors.forename: C
authors.initials: C
authors.lastname: Sergi
authors.forename: B
authors.initials: B
authors.lastname: Beedgen
authors.forename: O
authors.initials: O
authors.lastname: Linderkamp
authors.forename: W J
authors.initials: WJ
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D001201:Ascites / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D005865:Gestational Age; D006504:Hepatic Veno-Occlusive Disease / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008099:Liver / Q000473:pathology / Q000502:physiology; D008297:Male; D007752:Obstetric Labor, Premature; D011247:Pregnancy; D012016:Reference Values