Cell swelling activates STAT1 and STAT3 proteins in cultured rat hepatocytes.
In this paper, we demonstrated that in cultured rat hepatocytes cell swelling induced the activation of STAT1 and STAT3 proteins without any effect on STAT4, STAT5 and STAT6 proteins. Cell swelling induced an activation of STAT proteins through an increase in the phosphorylation of the tyrosine residue also phosphorylated by interleukin-6, but without any activation of JAK kinases. The signaling pathway by which cell swelling activated STAT1 and STAT3 is discussed.
Meisse
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Groupe de Biochimie et Physiopathologie Digestive et Nutritionnelle (GBPDN), Institut Fédératif de Recherche Multidisciplinaire sur les Peptides no. 23 (IFRMP), UFR Médecine-Pharmacie de Rouen, 22 boulevard Gambetta, 76183, Rouen, France.
Dusanter-Fourt
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I
Husson
A
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Lavoinne
A
A
D000818:Animals; D048429:Cell Size; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D015850:Interleukin-6 / Q000494:pharmacology; D053616:Janus Kinase 3; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D009994:Osmolar Concentration; D010766:Phosphorylation / Q000187:drug effects; D011505:Protein-Tyrosine Kinases / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D050794:STAT1 Transcription Factor; D050795:STAT2 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism*
D004268:DNA-Binding Proteins; D015850:Interleukin-6; C507936:Jak3 protein, rat; D050794:STAT1 Transcription Factor; D050795:STAT2 Transcription Factor; C494081:Stat1 protein, rat; D015534:Trans-Activators; D011505:Protein-Tyrosine Kinases; D053616:Janus Kinase 3