Treatment of severe chronic digoxin toxicosis in a dog with cardiac disease, using ovine digoxin-specific immunoglobulin G Fab fragments.
Severe digoxin toxicosis in a 13-year-old mixed-breed dog with dilated cardiomyopathy was successfully treated with i.v. administration of ovine digoxin-specific IgG Fab fragments. Management of this dog following treatment with Fab fragments was complicated by hypomagnesemia and loss of the positive inotropic effect of digoxin.
Ward
D M
DM
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442, USA.
Forrester
S D
SD
DeFrancesco
T C
TC
Troy
G C
GC
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001772:Blood Cell Count / Q000662:veterinary; D001774:Blood Chemical Analysis / Q000662:veterinary; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000662:veterinary*; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004077:Digoxin / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004562:Electrocardiography / Q000662:veterinary; D004656:Enalapril / Q000627:therapeutic use; D005260:Female; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage / Q000627:therapeutic use*; D007545:Isoproterenol / Q000627:therapeutic use; D008275:Magnesium Deficiency / Q000662:veterinary; D008278:Magnesium Sulfate / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D007140:Immunoglobulin Fab Fragments; D004656:Enalapril; D004077:Digoxin; D008278:Magnesium Sulfate; D007545:Isoproterenol