Synthesis and hypoglycaemic activity of some new flavone derivatives. Part 1: Flavonylsulphonylurea derivatives.
A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulphonamide (III). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose at least at the higher concentrations used.
Bozdag
O
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Turkey.
Verspohl
E J
EJ
Ertan
R
R
D000818:Animals; D002460:Cell Line / Q000187:drug effects / Q000378:metabolism; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D051381:Rats
D005419:Flavonoids; D007004:Hypoglycemic Agents