Abnormal liver function in workers exposed to low levels of ethylene dichloride and vinyl chloride monomer.
We investigated whether exposure to ethylene dichloride (EDC) and vinyl chloride monomer (VCM) resulted in increased risk of liver damage. Epidemiological information, including occupational, medical, smoking, and drinking history, was obtained by interview from 251 male workers. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were used as indicators of liver damage. Exposure to moderate or low levels of ECD and VCM resulted in a higher risk of developing abnormal ALT levels than did exposure to lower levels of the chemicals. Results were similar for AST. GGT was not associated with EDC or VCM exposure. Combined exposure to EDC and VCM showed a dose-response relationship in association with abnormal ALT levels. We concluded that relatively low concentrations of VCM and EDC cause liver damage.
Cheng
T J
TJ
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei.
Huang
M L
ML
You
N C
NC
Du
C L
CL
Chau
T T
TT
D000328:Adult; D000410:Alanine Transaminase / Q000032:analysis; D001219:Aspartate Aminotransferases / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005025:Ethylene Dichlorides / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008107:Liver Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D014752:Vinyl Chloride / Q000009:adverse effects*
D005025:Ethylene Dichlorides; C024565:ethylene dichloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D014752:Vinyl Chloride