Inhibitory effects of Astragali Radix, a crude drug in Oriental medicines, on lipid peroxidation and protein oxidative modification by copper.
Effects of Astragali Radix, the root of Astragalus membrauaceus Bunge, were investigated on oxidative stress such as lipid peroxidation and protein oxidative modification by copper. The results showed that these effects are similar to those of mannitol and superoxide dismutase as a free radical scavenger. It was demonstrated that Astragali Radix have inhibitory effects on oxidative stress induced by copper.
Toda
S
S
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Sen-nan, Osaka, Japan.
Shirataki
Y
Y
D003300:Copper / Q000494:pharmacology*; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008353:Mannitol / Q000494:pharmacology; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D010713:Phosphatidylcholines / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010713:Phosphatidylcholines; D010936:Plant Extracts; D011506:Proteins; D008353:Mannitol; D003300:Copper; D013482:Superoxide Dismutase