title: Recombinant human interleukin-10 fails to alter proinflammatory cytokine production or physiologic changes associated with the Jarisch-Herxheimer reaction.
abstract: Interleukin (IL)-10 may have a role in the treatment of cytokine-associated inflammatory syndromes. The Jarisch-Herxheimer reaction (J-HR), which follows antibiotic treatment of Borrelia recurrentis infection, is a useful model of acute systemic inflammation associated with a cytokine surge and characteristic pathophysiologic changes. In a double-blind, placebo-controlled study, 49 Ethiopian men with B. recurrentis infection were randomized to receive a single intravenous bolus of either 25 microg/kg of recombinant human (rh) IL-10 or vehicle control shortly before receiving intramuscular penicillin. Patients were monitored for physiologic changes, and plasma samples were taken repeatedly for 24 h after treatment. rhIL-10 had no impact on changes in any of the physiologic parameters of J-HR, plasma cytokine levels, or the rate of spirochete clearance. A single intravenous bolus of 25 microgram/kg of rhIL-10 does not seem to have a useful role in the treatment of the J-HR associated with B. recurrentis infection.
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. pcooper@niaid.nih.gov
authors.forename: P J
authors.initials: PJ
authors.lastname: Cooper
authors.forename: D
authors.initials: D
authors.lastname: Fekade
authors.forename: D G
authors.initials: DG
authors.lastname: Remick
authors.forename: P
authors.initials: P
authors.lastname: Grint
authors.forename: J
authors.initials: J
authors.lastname: Wherry
authors.forename: G E
authors.initials: GE
authors.lastname: Griffin
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005002:Ethiopia; D005334:Fever / Q000188:drug therapy*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D016753:Interleukin-10 / Q000627:therapeutic use*; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D012008:Recurrence; D012061:Relapsing Fever / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D016753:Interleukin-10