Streamlined synthesis of substituted 2-aminothiazoles using tandem precipitative and polymer-assisted reactions.
The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer-assisted transformations has been employed in the preparation of substituted 2-aminothiazole derivatives. 2-aminothiazoles were precipitated in parallel as hydrobromide monohydrate salts, directly redissolved, and reacted further using polymer-supported reagents to afford free-based 2-aminothiazoles, aminothiazoyloxamates, and aminothiazoylamides.
Yun
Y K
YK
Argonaut Technologies, 887 Industrial Road, Suite G, San Carlos, California 94070, USA.
Leung
S S
SS
Porco
J A
JA
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D011108:Polymers; D012116:Resins, Plant; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000998:Antiviral Agents; D007202:Indicators and Reagents; D011108:Polymers; D012116:Resins, Plant; D013844:Thiazoles; C004483:2-aminothiazole