A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy-(10alpha-2H)paclitaxel.
10-Deacetoxy-(10alpha-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.
Dutta
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D
Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
Hadd
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Vander Velde
D G
DG
Georg
G I
GI
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D003903:Deuterium; D009682:Magnetic Resonance Spectroscopy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D043823:Taxoids / Q000031:analogs & derivatives
C402708:10-deacetoxypaclitaxel; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D003903:Deuterium; D017239:Paclitaxel