Evidence for a mouse brain-specific variant of alpha-tubulin.
While studying the neural precursor cell intermediate filament protein known as nestin in the developing mouse brain, we observed a strong cross-reaction of our nestin antibody with a 50 kDa protein that appeared on embryonic day 10 and continued to accumulate until postnatal day 1. Here we report evidence that this protein is a brain-specific variant form of alpha-tubulin and discuss its implications.
Kong
L W
LW
Shanghai Institute of Biochemistry, Chinese Academy of Sciences.
Ding
X Y
XY
Kitani
H
H
Shiurba
R
R
Jing
N H
NH
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism*; D003429:Cross Reactions; D018985:Epitopes, B-Lymphocyte / Q000276:immunology; D005260:Female; D014644:Genetic Variation; D007381:Intermediate Filament Proteins / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D064231:Nestin; D009474:Neurons / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D013234:Stem Cells / Q000378:metabolism; D014404:Tubulin / Q000276:immunology / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D018985:Epitopes, B-Lymphocyte; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; C577485:Nes protein, mouse; C577486:Nes protein, rat; D064231:Nestin; D014404:Tubulin