title: 4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: potent and selective inhibitors of ZAP 70.
abstract: Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 70.
authors.affiliation: Celltech Therapeutics Limited, Slough, UK. dmoffat@celltech.co.uk
authors.forename: D
authors.initials: D
authors.lastname: Moffat
authors.forename: P
authors.initials: P
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Hutchings
authors.forename: J
authors.initials: J
authors.lastname: Davis
authors.forename: D
authors.initials: D
authors.lastname: Berg
authors.forename: M
authors.initials: M
authors.lastname: Batchelor
authors.forename: J
authors.initials: J
authors.lastname: Johnson
authors.forename: J
authors.initials: J
authors.lastname: O'Connell
authors.forename: R
authors.initials: R
authors.lastname: Martin
authors.forename: T
authors.initials: T
authors.lastname: Crabbe
authors.forename: J
authors.initials: J
authors.lastname: Delgado
authors.forename: M
authors.initials: M
authors.lastname: Perry
mesh_terms: D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D015398:Signal Transduction; D051746:ZAP-70 Protein-Tyrosine Kinase
chemical_list: D011743:Pyrimidines; D011505:Protein-Tyrosine Kinases; D051746:ZAP-70 Protein-Tyrosine Kinase