Separation of enantiomers on anion exchangers modified with heparin in liquid chromatography.
The separation of enantiomers of chloroquine and other amine derivatives has been investigated by liquid chromatography using anion exchangers modified with heparin as the stationary phase. Modification and mobile phase conditions affected the separation of analytes. Separation of the chloroquine enantiomers could be achieved by using a buffer solution containing acetonitrile as the mobile phase.
Safni
Department of Chemistry, Faculty of Engineering, Gifu University, Japan.
Ito
N
N
Takeuchi
T
T
Miwa
T
T
D000097:Acetonitriles; D017920:Antiporters; D002021:Buffers; D002738:Chloroquine / Q000737:chemistry / Q000302:isolation & purification*; D002852:Chromatography, Ion Exchange / Q000379:methods*; D006493:Heparin / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D013237:Stereoisomerism
D000097:Acetonitriles; D017920:Antiporters; D002021:Buffers; D002738:Chloroquine; D006493:Heparin; C032159:acetonitrile