title: Plasma exchange for acquired hemophilia: a case report.
abstract: A patient with acquired hemophilia complicated with chronic renal failure and lung tuberculosis was successfully treated by consecutive plasma exchange (PE). A 71-year-old man with serious bleeding tendency showed low coagulation factor levels and a high titer of factor VIII (FVIII) inhibitor, and he was diagnosed with acquired hemophilia. Because of the complication of active lung tuberculosis, instead of immunosuppressive therapy, he undertook a series of PE with fresh frozen plasma replacement for 3 months. After the start of PE, his bleeding symptoms and activated partial thromboplastin time (APTT) improved gradually according to the decrease in FVIII inhibitor levels. These results suggest that PE is an effective therapeutic tool for refractory acquired hemophilia.
authors.affiliation: Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ogata
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.forename: F
authors.initials: F
authors.lastname: Koiwa
authors.forename: H
authors.initials: H
authors.lastname: Tayama
authors.forename: E
authors.initials: E
authors.lastname: Kinugasa
authors.forename: T
authors.initials: T
authors.lastname: Ideura
authors.forename: T
authors.initials: T
authors.lastname: Akizawa
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D007166:Immunosuppressive Agents; D005169:Factor VIII