title: Synthesis of a fluorescent microgonotropen (FMGT-1) and its interactions with the dodecamer d(CCGGAATTCCGG).
abstract: A new type of microgonotropen that fluoresces upon binding to dsDNA has been synthesized. FMGT-1, an analogue of the minor groove binder Hoechst 33258, is functionalized with a polyamine chain capable of interacting with the phosphate backbone of DNA. Binding studies indicate that FMGT-1 binds more tightly to dsDNA than the parent compound Hoechst 33258.
authors.affiliation: Department of Chemistry, University of California, Santa Barbara 93106, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Satz
authors.forename: T C
authors.initials: TC
authors.lastname: Bruice
mesh_terms: D001483:Base Sequence; D006690:Bisbenzimidazole / Q000031:analogs & derivatives; D004268:DNA-Binding Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D004268:DNA-Binding Proteins; D005456:Fluorescent Dyes; D009838:Oligodeoxyribonucleotides; D006690:Bisbenzimidazole