title: The effects of peracetic acid-hydrogen peroxide reprocessing on dialyzer solute and water permeability.
abstract: We characterized the effects of peracetic acid-hydrogen peroxide (PAHP) reprocessing on hemodialyzer permeability to water and solutes of various molecular weights and compared these effects within and between dialyzers. An aqueous-based solution containing urea, creatinine, vancomycin, inulin, myoglobin, and albumin was dialyzed for 60 minutes with a hemodialyzer after undergoing 0, 1 , 5, 10, and 15 reuse cycles. Solute clearance, sieving coefficient (SC), and ultrafiltration coefficient were determined. We found that PAHP reprocessing significantly decreased water and solute removal (urea, creatinine, vancomycin, inulin) by cellulose triacetate dialyzers (CT190) over 15 reuses (p<0.05) but did not affect the permeability of polysulfone dialyzers (F80A). Inulin removal was significantly lower for F80A than for CT190 (p<0.0001 and p<0.001 for clearance and SC values, respectively). Myoglobin and albumin removal by CT190 significantly decreased over 15 reuses (p<0.05), but no protein was detected in dialysate or ultrafiltrate at any reuse number for F80A. Reprocessing with PAHP alters dialyzer permeability; the effect is more pronounced for the CT190 dialyzer, but removal of solutes with molecular weight above 1500 Da is significantly lower with F80A dialyzers than with CT190. These changes in dialyzer permeability should be considered when determining optimal reuse procedures.
authors.affiliation: Department of Pharmacy Practice, School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, Indiana 46202, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Scott
authors.forename: B A
authors.initials: BA
authors.lastname: Mueller
authors.forename: K M
authors.initials: KM
authors.lastname: Sowinski
mesh_terms: D003404:Creatinine / Q000493:pharmacokinetics; D015312:Hemodialysis Solutions / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D066298:In Vitro Techniques; D007444:Inulin / Q000493:pharmacokinetics; D009211:Myoglobin / Q000493:pharmacokinetics; D010463:Peracetic Acid / Q000737:chemistry*; D010539:Permeability; D011897:Random Allocation; D006435:Renal Dialysis / Q000379:methods*; D012709:Serum Albumin / Q000493:pharmacokinetics; D013997:Time Factors; D014508:Urea / Q000493:pharmacokinetics; D014640:Vancomycin / Q000493:pharmacokinetics; D014867:Water / Q000378:metabolism*
chemical_list: D015312:Hemodialysis Solutions; D009211:Myoglobin; D012709:Serum Albumin; D014867:Water; D014640:Vancomycin; D014508:Urea; D007444:Inulin; D003404:Creatinine; D006861:Hydrogen Peroxide; D010463:Peracetic Acid