title: Optimizing computerized treatment planning for the Gamma Knife by source culling.
abstract: OBJECTIVE
  A good plan is crucial to the success of gamma knife treatment, which depends not only on parameters such as the number of shots, shot position, collimator sizes, and shot weight, but also on the number of blocked cobalt sources. However, during treatment, a plug is generally used to block those cobalt sources, so the beam cannot reach critical tissues. We present here an automated method to optimize all of those parameters, and to choose a source set, although the beams of some blocked sources do not hit any critical tissue. This strategy is used to achieve a high dose that better conforms to the tumor shape, and at the same time, avoids healthy tissue.
  
  
  METHODS
  Using a workstation that integrates the gamma knife treatment planning system, we developed a two-step optimization algorithm. First, we used a modified Powell's method to optimize the location of the shot, collimator size, and shot weight; we used simulated annealing to determine if the number of shots was adequate using this parameter. Then, simulated annealing was used to determine which cobalt sources we needed to block.
  
  
  RESULTS
  Application of this optimization method in two cases showed that the treatment plan can be much improved when the set of blocked cobalt sources has been taken into consideration.
  
  
  CONCLUSIONS
  Determining the set of blocked sources is necessary in certain cases. This technique better conforms the desired isodose curves to the outline of the target volume and minimizes damage to the surrounding normal tissues.
authors.affiliation: Department of Biology and Medical Engineering, Southeast University, Nanjing, China.
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: H
authors.initials: H
authors.lastname: Shu
authors.forename: W
authors.initials: W
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Bao
authors.forename: Y
authors.initials: Y
authors.lastname: Fu
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000601:surgery; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D016018:Least-Squares Analysis; D055585:Physical Phenomena; D010825:Physics; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*
chemical_list: D003037:Cobalt Radioisotopes