[Tissue distribution of orthotolidine and pathways of its elimination].
Distribution of the carcinogenic agent orthotolidine (OT) in the rat's body has been investigated by diazotizing technique. Levels of free amines were 1.5-2 times those in control 3 days after the last administration (total treatment duration-8 months). Zymbal gland, the target tissue, showed the highest concentrations. Also, bound amine concentrations in Zymbal gland soared up (8 times those in control). Similar results were reported 7 days after the last administration of OT: free amine level in the same site was 7 times that in control. Enhanced free and bound amine concentrations may point to its being withdrawn through Zymbal gland ducts. This may also promote carcinogenesis in them.
Pliss
G B
GB
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009852:Omentum / Q000378:metabolism; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D014052:Toluidines / Q000008:administration & dosage / Q000378:metabolism*; D014781:Viscera / Q000378:metabolism*
D002273:Carcinogens; D014052:Toluidines; C023622:2-toluidine