Salivary fluoride concentrations following applications of bioadhesive tablets and mouthrinses.
Presence of elevated fluoride concentration in saliva is important for the prevention of caries. In the present study, we developed an intra-oral bioadhesive tablet aimed at delivering F(-) in the mouth over a prolonged period of time. Various tablet formulations were tested in vivo for their tolerance and adhesiveness. Two formulations were selected for further studies on salivary fluoride clearance. For comparison, mouthrinses with increasing F(-) concentrations were also examined. Results indicate that a bioadhesive tablet located on the upper gingiva is able to sustain salivary F(-) concentrations for about 10h without major side effects. Mouthrinses with high F(-) concentration were able to prolong salivary fluoride retention for more than 6h.
Vivien-Castioni
N
N
School of Dental Medicine, University of Geneva, Geneva, Switzerland. nathalie.viviencastioni@medecine.unige.ch
Gurny
R
R
Baehni
P
P
Kaltsatos
V
V
D000269:Adhesives / Q000493:pharmacokinetics*; D000278:Administration, Buccal; D000328:Adult; D002327:Cariostatic Agents / Q000493:pharmacokinetics*; D005260:Female; D005459:Fluorides / Q000493:pharmacokinetics*; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000493:pharmacokinetics*; D012463:Saliva / Q000378:metabolism*; D013607:Tablets
D000269:Adhesives; D002327:Cariostatic Agents; D009067:Mouthwashes; D013607:Tablets; D005459:Fluorides