title: [The prognosis following surgical resection of small-cell nonanaplastic bronchogenic carcinoma according to the new staging guideline: an analysis of 1433 patients].
abstract: OBJECTIVE
  To validate current guidelines for staging bronchogenic lung carcinoma.
  
  
  METHODS
  Between 1969 and 1996, small-cell non-anaplastic tumors of bronchogenic carcinoma classified by the recently proposed TNM guidelines of the Spanish Society of Pneumology and Chest Surgery (SEPAR) were resected from 1,433 patients. We used the Kaplan-Meier method to calculate survival and compared the curves using a log-rank test.
  
  
  RESULTS
  A stage IA classification was given to 142 patients and IB to 575. Thirty-seven cases were classified IIA and 336 were IIB. Of the latter, 177 were T2N1M0 and 159 were T3N0M0. Two hundred forty-eight patients were in stage IIIA, 54 T3N1M0, 23 T1N2M0, 120 T2N2M0 and 51 T3N2M0. Ninety-five stage IIIB patients were classified as follows: 37 T4N0M0, 35 T4N1M0, and 23 T4N2M0. Five-year survival for IA patients, at 75% was significantly better than the 60% rate for IB patients (p = 0.0021). Likewise, the prognosis for stage IIA, where five-year survival was 57%, was significantly better than for IIB at 39% (p = 0.0434). The prognosis for patients classified as T1NM0 was better than for those classified as T2N1M0, which was 38% (p = 0.0320). The survival of those classified as T3N0M0 (42%) was not significantly different from that of T1N1M0 (p = 0.1754) or T2N1M0 (p = 0.5360) patients. We found no significant difference between T1N1M0 and stage IB (p = 0.3847) patients. Among stage III patients, we observed no difference in survival between stage IIIA and IIIB (p = 0.1914). In stage IIIA, patients classified as T3N2M0 had a significantly lower rate of survival (p = 0.0399). The presence of mediastinal ganglia in stage IIIB was associated with a lower survival rate (p = 0.0328).
  
  
  CONCLUSIONS
  The new guidelines for staging non-small cell anaplastic lung carcinoma do not provide consistent prognoses for homogeneous groups of patients, at least not in certain categories.
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario La Fe, Valencia. jpadilla@comv.es
authors.forename: J
authors.initials: J
authors.lastname: Padilla
authors.forename: V
authors.initials: V
authors.lastname: Calvo
authors.forename: A
authors.initials: A
authors.lastname: García Zarza
authors.forename: J
authors.initials: J
authors.lastname: Pastor
authors.forename: E
authors.initials: E
authors.lastname: Blasco
authors.forename: F
authors.initials: F
authors.lastname: París
mesh_terms: D002283:Carcinoma, Bronchogenic / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011013:Pneumonectomy / Q000706:statistics & numerical data; D011379:Prognosis; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis