title: Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.
abstract: The benzothiophene LY329146 reverses the drug resistance phenotype in multidrug resistance protein (MRP1)-overexpressing cells when dosed in combination with MRP1-associated oncolytics doxorubicin and vincristine. Additionally, LY329146 inhibited MRP1-mediated uptake of the MRP1 substrate LTC4 into membrane vesicles prepared from MRP1-overexpressing cells.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
authors.forename: B H
authors.initials: BH
authors.lastname: Norman
authors.forename: A H
authors.initials: AH
authors.lastname: Dantzig
authors.forename: J S
authors.initials: JS
authors.lastname: Kroin
authors.forename: K L
authors.initials: KL
authors.lastname: Law
authors.forename: L B
authors.initials: LB
authors.lastname: Tabas
authors.forename: R L
authors.initials: RL
authors.lastname: Shepard
authors.forename: A D
authors.initials: AD
authors.lastname: Palkowitz
authors.forename: K L
authors.initials: KL
authors.lastname: Hauser
authors.forename: M A
authors.initials: MA
authors.lastname: Winter
authors.forename: J P
authors.initials: JP
authors.lastname: Sluka
authors.forename: J J
authors.initials: JJ
authors.lastname: Starling
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D018432:Drug Resistance, Multiple / Q000235:genetics*; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D017997:Leukotriene C4 / Q000037:antagonists & inhibitors / Q000378:metabolism; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D013449:Sulfonamides / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D017997:Leukotriene C4; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D013449:Sulfonamides; D013876:Thiophenes; C402711:LY 329146