Ganglioglioma in a patient with Turcot syndrome. Case report.
A 33-year-old woman with Turcot syndrome harbored a brain tumor and colon cancer and had a familial history of this syndrome. On histological examination, the brain tumor was found to have large and diffusely scattered ganglion cells within a diffuse background of astrocytic cells in a fibrillary matrix. The tumor was diagnosed as a ganglioglioma. No germline mutation in the adenomatous polyposis coli gene was detected using a protein truncation assay. These findings indicate that this patient had brain tumor-polyposis syndrome Type 1 of Turcot syndrome. This is the first report of a ganglioglioma related to Turcot syndrome.
Tamiya
T
T
Department of Neurological Surgery, Okayama University Medical School, Japan. ttamiya@med.okayama-u.ac.jp
Hamazaki
S
S
Ono
Y
Y
Tokunaga
K
K
Matsumoto
K
K
Furuta
T
T
Ohmoto
T
T
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D018303:Ganglioglioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging