Developmental toxicity of diethanolamine applied cutaneously to CD rats and New Zealand White rabbits.
Diethanolamine (DEA) was administered cutaneously to pregnant CD rats and New Zealand White rabbits during the periods of major organogenesis, Gestation Days 6-15 for rats and 6-18 for rabbits. Doses employed were 0, 150, 500, and 1500 mg/kg/day for rats and 0, 35, 100, and 350 mg/kg/day for rabbits. Rat dams exhibited reduced body weight at 1500 mg/kg/day, skin irritation and increased kidney weights at 500 and 1500 mg/kg/day, and a slight microcytic anemia with abnormal red blood cell morphology at all dose levels. Rat fetuses had increased incidences of six skeletal variations at 1500 mg/kg/day. Lower doses were without effect on the fetuses. Rabbit dams administered 350 mg/kg/day exhibited various skin lesions, reduced food consumption, and color changes in the kidneys but no hematological changes. Body weight gain was reduced at >/=100 mg/kg/day. There was no evidence of maternal toxicity at 35 mg/kg/day and no evidence of developmental toxicity in rabbits at any dose level. Developmental toxicity was observed only in the rat and only at doses causing significant maternal toxicity, including hematological effects. Due to a dose discrepancy, the no observable effect level (NOEL) for DEA developmental toxicity in rats was adjusted to 380 mg/kg/day. In rabbits, the embryonal/fetal NOEL was 350 mg/kg/day.
Marty
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MS
The Dow Chemical Company, 1803 Building, Midland, Michigan 48674, USA.
Neeper-Bradley
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TL
Neptun
D A
DA
Carney
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EW
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000279:Administration, Cutaneous; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D017453:Dermatitis, Irritant / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D004983:Ethanolamines / Q000633:toxicity*; D005260:Female; D005865:Gestational Age; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects
D004983:Ethanolamines; C020283:diethanolamine