title: Cholecystokinin-8-like immunoreactivity is sexually dimorphic in a midline population of rat lumbar neurons.
abstract: The gray matter surrounding the central canal of rat lumbar spinal cord contains a population of spinothalamic neurons which has been shown to co-contain cholecystokinin-8 (CCK-8) and galanin (GAL) (Ju, G., Melander, T., Hökfelt, T. and Frey, P., Immunohistochemical evidence for a spinothalamic pathway co-containing cholecystokinin- and galanin-like immunoreactivities in the rat. Neuroscience, 20 (1987) 439-456). A previous study from our laboratory has shown that female rats have only 62% the number of GAL-containing midline neurons present in males. Counts of CCK-8-containing midline neurons reveal that females have 59% the number observed in males. These results indicate that the degree of sexual dimorphism seen for CCK-8 is the same for GAL in these midline lumbar neurons, and suggests that androgens modulate the production of the co-contained GAL and CCK-8 in a similar fashion within male rat spinal cords.
authors.affiliation: Department of Anatomy and Center for Neuroscience, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Phan
authors.forename: B W
authors.initials: BW
authors.lastname: Newton
mesh_terms: D000818:Animals; D002452:Cell Count; D005260:Female; D019004:Galanin / Q000378:metabolism; D008161:Lumbosacral Region; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D012844:Sincalide / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*
chemical_list: D019004:Galanin; D012844:Sincalide