BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis.
The Arabidopsis bas1-D mutation suppresses the long hypocotyl phenotype caused by mutations in the photoreceptor phytochrome B (phyB). The adult phenotype of bas1-D phyB-4 double mutants mimics that of brassinosteroid biosynthetic and response mutants. bas1-D phyB-4 has reduced levels of brassinosteroids and accumulates 26-hydroxybrassinolide in feeding experiments. The basis for the mutant phenotype is the enhanced expression of a cytochrome P450 (CYP72B1). bas1-D suppresses a phyB-null allele, but not a phyA-null mutation, and partially suppresses a cryptochrome-null mutation. Seedlings with reduced BAS1 expression are hyperresponsive to brassinosteroids in a light-dependent manner and display reduced sensitivity to light under a variety of conditions. Thus, BAS1 represents one of the control points between multiple photoreceptor systems and brassinosteroid signal transduction.
Neff
M M
MM
Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Nguyen
S M
SM
Malancharuvil
E J
EJ
Fujioka
S
S
Noguchi
T
T
Seto
H
H
Tsubuki
M
M
Honda
T
T
Takatsuto
S
S
Yoshida
S
S
Chory
J
J
D017360:Arabidopsis / Q000235:genetics* / Q000378:metabolism / Q000528:radiation effects; D029681:Arabidopsis Proteins; D060406:Brassinosteroids; D002777:Cholestanols / Q000494:pharmacology; D056931:Cryptochromes; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D029721:Drosophila Proteins; D005136:Eye Proteins; D005420:Flavoproteins / Q000235:genetics; D017343:Genes, Plant; D008027:Light; D009154:Mutation; D010544:Peroxidases / Q000235:genetics*; D054464:Peroxiredoxins; D010786:Photoreceptor Cells; D017956:Photoreceptor Cells, Invertebrate; D010834:Phytochrome / Q000235:genetics; D051939:Phytochrome B; D010840:Phytosterols / Q000096:biosynthesis*; D010947:Plants, Toxic; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction; D013260:Steroids, Heterocyclic / Q000494:pharmacology; D013489:Suppression, Genetic; D014026:Nicotiana / Q000235:genetics; D014157:Transcription Factors; D014170:Transformation, Genetic
D029681:Arabidopsis Proteins; D060406:Brassinosteroids; C538962:CRY1 protein, Arabidopsis; D002777:Cholestanols; D056931:Cryptochromes; D029721:Drosophila Proteins; D005136:Eye Proteins; D005420:Flavoproteins; C497952:PHYB protein, Arabidopsis; D010840:Phytosterols; D043562:Receptors, G-Protein-Coupled; D013260:Steroids, Heterocyclic; D014157:Transcription Factors; C119828:cry protein, Drosophila; D010834:Phytochrome; D051939:Phytochrome B; D010544:Peroxidases; C108214:BAS1 protein, Arabidopsis; D054464:Peroxiredoxins; C023623:brassinolide