title: EDTA chelation therapy does not selectively increase chromium losses.
abstract: Chelation therapy and supplemental Cr have both been shown to lead to improved blood glucose, lipids, and insulin activity. Chelation therapy leads to the removal of toxic as well as essential metals. To determine if chelation therapy leads to increased urinary Cr losses and altered Cr homeostasis, 2 groups of subjects (1 group that had undergone only 1 or no chelation therapy and 1 group in which all subjects had undergone at least 19 chelation sessions) were evaluated for differences in possible Cr homeostasis based on urinary Cr losses. There were no significant differences in urinary Cr losses between the two groups of subjects and there were no significant increases in urinary Cr losses resulting from chelation therapy. Increases in urinary Cr losses were strongly influenced by supplementation but not chelation therapy.
authors.affiliation: Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, U.S. Department of Agriculture, Agricultural Research Service, MD 20705-2350, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Anderson
authors.forename: N A
authors.initials: NA
authors.lastname: Bryden
authors.forename: R
authors.initials: R
authors.lastname: Waters
mesh_terms: D000368:Aged; D002614:Chelating Agents / Q000737:chemistry*; D002857:Chromium / Q000008:administration & dosage / Q000652:urine*; D004492:Edetic Acid / Q000737:chemistry*; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male
chemical_list: D002614:Chelating Agents; D002857:Chromium; D004492:Edetic Acid