Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice.
Control of ganglionic herpes simplex virus (HSV) infection depends on CD8(+) cells but not on the death of infected neurons. Primarily, perforin and granzyme B mediate CD8(+) cell cytotoxicity, whereas the in vivo functions of granzyme A, a third granule protein, are unknown. Here, it is shown that granzyme A restricts the interneuronal spread of HSV and significantly influences ganglionic virus load.
Pereira
R A
RA
Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Adelaide, South Australia 5000, Australia. Rosemary.Pereira@imvs.sa.gov.au
Simon
M M
MM
Simmons
A
A
D000818:Animals; D000998:Antiviral Agents / Q000502:physiology*; D004195:Disease Models, Animal; D005727:Ganglia, Spinal / Q000276:immunology / Q000473:pathology / Q000821:virology; D053804:Granzymes; D006561:Herpes Simplex / Q000276:immunology* / Q000473:pathology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000502:physiology; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017933:Peripheral Nervous System / Q000821:virology*; D012697:Serine Endopeptidases / Q000235:genetics / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D019562:Viral Load
D000998:Antiviral Agents; D053804:Granzymes; D012697:Serine Endopeptidases; C509212:GZMA protein, human