title: Strategies for molecular intervention in esophageal cancers and their precursor lesions.
abstract: Molecular analysis of malignant transformation in Barrett's epithelium provides insight into the temporal nature and significance of individual genetic events during multistep esophageal carcinogenesis. Potential targets for intervention in esophageal neoplasms include mutations involving retinoblastoma (Rb) and p53 tumor-suppressor pathways as well as tyrosine kinase cascades, which are known to promote cell cycle progression. Data from recent experiments provide the preclinical rationale for novel pharmacologic interventions in established esophageal cancers, and suggest strategies for chemoprevention in patients at risk for the development of these neoplasms.
authors.affiliation: Thoracic Oncology Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Schrump
authors.forename: D M
authors.initials: DM
authors.lastname: Nguyen
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000256:Adenoviridae; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000235:genetics / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D005419:Flavonoids / Q000627:therapeutic use; D016158:Genes, p53; D005822:Genetic Vectors; D006801:Humans; D010880:Piperidines / Q000627:therapeutic use; D011230:Precancerous Conditions / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D010880:Piperidines; C077990:alvocidib