title: Adenocarcinoma at the esophageal gastric junction arising in an 11-year-old girl.
abstract: Gastric adenocarcinoma is one of the most common gastrointestinal (GI) malignancies, especially among Japanese adults, but represents only 0.05% of all malignant pediatric GI tumors. We report a case of gastric adenocarcinoma arising at the esophageal gastric junction of an 11-year-old girl. The tumor was polypoid, measuring 3.0 x 3.0 x 1.2 cm and was light gray and partially red in color with a stalk. Light microscopic examination of the lesion demonstrated adenocarcinoma of variable degrees of both architectural and nuclear atypia with invasion into the submucosa. Immunohistochemical findings of cytokeratin subtypes revealed positive immunoreactivity for cytokeratin subtypes 8, 19 and 20 and negative for 5/6/18, 7, 13 and 14, which is consistent with those of gastric adenocarcinoma. The patient was alive and well 12 months postoperatively.
authors.affiliation: Department of Pediatric Surgery, Tohoku University School of Medicine, Sendai, Japan. h-sasaki@ped-surg.med.tohoku.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Sasano
authors.forename: R
authors.initials: R
authors.lastname: Ohi
authors.forename: M
authors.initials: M
authors.lastname: Imaizumi
authors.forename: R
authors.initials: R
authors.lastname: Shineha
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: D
authors.initials: D
authors.lastname: Shibuya
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002648:Child; D002945:Cisplatin / Q000627:therapeutic use; D016629:Esophagectomy; D004943:Esophagogastric Junction / Q000473:pathology*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D007633:Keratins; D002945:Cisplatin; D005472:Fluorouracil