title: Monoubiquitination is sufficient to signal internalization of the maltose transporter in Saccharomyces cerevisiae.
abstract: Monoubiquitination of the 12-transmembrane segment (12-TMS) Saccharomyces cerevisiae maltose transporter promoted the maximal internalization rate of this protein. This modification is similar to that of the 7-TMS alpha-factor receptor but different from that of the 12-TMS uracil and general amino acid permeases. This result shows that binding of ubiquitin-Lys63 chains is not required for maximal internalization of all 12-TMS-containing proteins.
authors.affiliation: Instituto de Investigaciones Biomédicas "Alberto Sols," Consejo Superior de Investigaciones Científicas, 28029 Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Lucero
authors.forename: E
authors.initials: E
authors.lastname: Peñalver
authors.forename: L
authors.initials: L
authors.lastname: Vela
authors.forename: R
authors.initials: R
authors.lastname: Lagunas
mesh_terms: D004705:Endocytosis / Q000235:genetics; D010450:Endopeptidases; D056827:Endosomal Sorting Complexes Required for Transport; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction; D043222:Ubiquitin Thiolesterase; D014452:Ubiquitins / Q000235:genetics* / Q000378:metabolism*
chemical_list: C084434:DOA4 protein, S cerevisiae; D056827:Endosomal Sorting Complexes Required for Transport; D005656:Fungal Proteins; D009004:Monosaccharide Transport Proteins; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins; D010450:Endopeptidases; D043222:Ubiquitin Thiolesterase