title: The transporter associated with antigen processing TAP: structure and function.
abstract: The transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum (ER) is an essential process for presentation to cytotoxic T-lymphocytes. The transporter associated with antigen processing (TAP) is responsible for the intracellular translocation of peptides across the membrane of the ER. Efficient assembly of MHC-peptide complex requires the formation of a macromolecular transport and chaperone complex composed of TAP, tapasin and MHC class I molecules. Therefore, structure and function of TAP is important for the understanding of the immune surveillance.
authors.affiliation: Institut für Physiologische Chemie, Philipps-Universität Marburg, Karl-von-Frisch-Str. 1, 35033, Marburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Lankat-Buttgereit
authors.forename: R
authors.initials: R
authors.lastname: Tampé
mesh_terms: D000941:Antigens / Q000378:metabolism*; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004194:Disease; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D000941:Antigens; D002352:Carrier Proteins