Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages.
The structures of phenochalasins A and B were elucidated by spectroscopic studies including various NMR measurements. Phenochalasins A and B have the cytochalasan skeleton of the 21,23-dioxa, 17,22-dione moiety containing unique phenyl and O-methyl phenyl residues at the C-10 position, respectively.
Tomoda
H
H
Graduate School of Pharmaceutical Sciences, Kitasato University, Japan.
Namatame
I
I
Tabata
N
N
Kawaguchi
K
K
Si
S
S
Omura
S
S
D000818:Animals; D003572:Cytochalasins / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D050356:Lipid Metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure
D003572:Cytochalasins; D007211:Indoles; D007783:Lactones; C402691:phenochalasin A; C402692:phenochalasin B; C007215:cytochalasin E