[Hypoglycemia and the brain: metabolism and the mechanisms of neuronal damage].
Hypoglycaemia is a widely distributed pathological state, which develops in case of insulinoma of pancreas, alcohol intoxication, lever and gastrointestinal problems [2, 4, 7, 8, 9, 11, 28]. The most important clinic aspect is that it is associated with treatment of diabetes [2, 7, 8, 19, 28]. Hypoglycaemia may lead to irrecoverable damage to neurons and persistent disruption of the cerebral functions--post-hypoglycaemic encephalopathy; therefore, the metabolic changes resulting from neuroglycopenia and their relationship with neurotic disturbances, as well as the biochemical mechanisms leading to irrecoverable damage to cells are of special interest. Hypoglycaemia is a unique possibility to study these mechanisms, because it leads to cell damage even if there is no disturbance of oxygen supply to brain and intracellular acidosis [35, 38, 133].
Telushkin
P K
PK
Yaroslavl State Medical Academy.
Nozdrachev
A D
AD
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002952:Citric Acid Cycle; D003128:Coma / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D007003:Hypoglycemia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D010101:Oxygen Consumption
D005947:Glucose