title: Remifentanil and propofol for sedation in children and young adolescents undergoing diagnostic flexible bronchoscopy.
abstract: Flexible fibreoptic bronchoscopy (FOB) has become a useful diagnostic and therapeutic procedure in children. We investigated 26 patients (3-14 years) for FOB using a new sedation strategy. All patients received oral premedication and inhalation of topical anaesthetic. Sedation for bronchoscopy was achieved with a continuous infusion of remifentanil and intermittent boluses of propofol. Propofol injection was repeated if sedation was inadequate. Sedation could be successfully performed in all children without adverse effects. Endtidal CO2 concentration and arterial oxygen saturation remained stable throughout the study. All children were awake 5+/-1.3 min after stopping remifentanil infusion. Sedation with remifentanil/propofol is a new sedation strategy for diagnostic flexible paediatric bronchoscopy in children with spontaneous ventilation.
authors.affiliation: Klinik für Anästhesiologie, Rheinisch Westfälisch Hochschule Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Reyle-Hahn
authors.forename: B
authors.initials: B
authors.lastname: Niggemann
authors.forename: M
authors.initials: M
authors.lastname: Max
authors.forename: R
authors.initials: R
authors.lastname: Streich
authors.forename: R
authors.initials: R
authors.lastname: Rossaint
mesh_terms: D000293:Adolescent; D018686:Anesthetics, Intravenous; D001999:Bronchoscopy; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005336:Fiber Optic Technology; D006801:Humans; D006993:Hypnotics and Sedatives; D010880:Piperidines; D015742:Propofol; D000077208:Remifentanil
chemical_list: D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol