title: [Neonatal alloimmune neutropenias. Importance of treatment with granulocyte colony-stimulating factor (G-CSF). Report of 2 new cases].
abstract: Alloimmune neonatal neutropenia is a rare event. Usually asymptomatic, it may however in some cases result in a severe sepsis. Treatment with recombinant granulocyte colony-stimulating factor (G-CSF) has been recently proposed.
  
  
  METHODS
  We report two new cases in infected newborns of a successful treatment of alloimmune neonatal neutropenia with G-CSF, resulting in complete neutrophil recovery in less than 72 hours. Moreover, the treatment was well tolerated.
  
  
  CONCLUSIONS
  The analysis of these two cases and of those previously reported indicates that G-CSF represents the first-choice treatment in this affection when infectious signs are present in the neonate.
authors.affiliation: Service de néonatologie, Hôpital Robert-Debré, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Bédu
authors.forename: P
authors.initials: P
authors.lastname: Rohrlich
authors.forename: C
authors.initials: C
authors.lastname: Farnoux
authors.forename: M
authors.initials: M
authors.lastname: Duval
authors.forename: O
authors.initials: O
authors.lastname: Fenneteau
authors.forename: C
authors.initials: C
authors.lastname: Boissinot
authors.forename: D
authors.initials: D
authors.lastname: Pinquier
authors.forename: J
authors.initials: J
authors.lastname: Cartron
authors.forename: E
authors.initials: E
authors.lastname: Vilmer
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
mesh_terms: D000367:Age Factors; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology; D008297:Male; D009503:Neutropenia / Q000276:immunology* / Q000628:therapy*; D013997:Time Factors
chemical_list: D007519:Isoantigens; D016179:Granulocyte Colony-Stimulating Factor