title: Gelatin-containing diphtheria-tetanus-pertussis (DTP) vaccine causes sensitization to gelatin in the recipients.
abstract: Gelatin-specific T cell response was performed to determine whether a series of vaccinations with gelatin-containing DTP is a primary sensitization process in gelatin allergy. Thirty-seven recipients with gelatin-containing DTP who developed adverse reactions after vaccination and eight recipients of DTP without gelatin who also developed adverse reactions were studied. In addition, 10 subjects receiving gelatin-containing vaccine and 10 subjects inoculated with non-gelatin vaccine who did not show any adverse reactions were also investigated. All subjects inoculated with gelatin-containing DTP vaccine showed positive T cell responses against gelatin, however, occurrence of adverse reactions did not correlate with T cell responses. We conclude that DTP vaccine containing gelatin induces sensitization to gelatin in the recipients, but the mechanism of local reactions remains unknown.
authors.affiliation: Pediatric Allergy and Infectious Diseases Society of Sapporo, Kumagai Pediatric Clinic, W-6, Momijidai, Atsubetsu-ku, 004-0013, Sapporo, Japan. tkuma@mb.infosnow.ne.jp
authors.forename: T
authors.initials: T
authors.lastname: Kumagai
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
authors.forename: M
authors.initials: M
authors.lastname: Kamada
authors.forename: C
authors.initials: C
authors.lastname: Igarashi
authors.forename: K
authors.initials: K
authors.lastname: Yuri
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
authors.forename: K
authors.initials: K
authors.lastname: Wagatuma
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Okui
authors.forename: S
authors.initials: S
authors.lastname: Yano
mesh_terms: D002648:Child; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005780:Gelatin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007223:Infant; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D007376:Interleukin-2; D007073:Immunoglobulin E; D005780:Gelatin