Radical scavenging activity of tea catechins and their related compounds.
(-)-Epigallocatechin gallate was found to be the most effective scavenger among tea catechins for the superoxide anion, hydroxyl radical, and 1,1-diphenyl-3-picrylhydrazyl radical. Examination of the scavenging effects of tea catechins and their glucosides on superoxide anion showed that the presence of at least an ortho-dihydroxyl group in the B ring and a galloyl moiety at the 3 position was important in maintaining the effectiveness of the radical scavenging ability. Stoichiometric factors of tea catechins were estimated to be 2 for (+)-catechin and (-)-epicatechin, 5 for (-)-epigallocatechin, 7 for (-)-epicatechin gallate, and 10 for (-)-epigallocatechin gallate.
Nanjo
F
F
Food Research Institute, Mitsui Norin Co. Ltd., Shizuoka, Japan. KYPO3677@nifty.ne.jp
Mori
M
M
Goto
K
K
Hara
Y
Y
D015764:Bepridil / Q000031:analogs & derivatives / Q000737:chemistry; D001713:Biphenyl Compounds; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000737:chemistry; D066298:In Vitro Techniques; D010851:Picrates; D013481:Superoxides / Q000737:chemistry; D013662:Tea / Q000737:chemistry*
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013662:Tea; D013481:Superoxides; D017665:Hydroxyl Radical; D015764:Bepridil; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate; C004931:1,1-diphenyl-2-picrylhydrazyl