[Recent findings on the genetics of Behçet's disease].
Behçet's disease is a systemic inflammatory disease with a multifactorial genetic and environmental pathogenesis. The main factor of genetic predisposition is located in the HLA region. The disease is significantly linked with the HLA-B51 antigen in different ethnic groups. Recently, a linkage with MICA gene polymophism has been evidenced. This gene, located 46 kb centromerically from the HLA-B gene, codes for a non-classic HLA class I protein induced by stress and probably plays an important role in the destruction of cells targeted by Tgd lymphocytes. The functional significance of this polymorphism in Behçet's disease remains unclear.
Hüe-Lemoine
S
S
Laboratoire d'Immunologie, Hôpital Necker, Paris.
Amoura
Z
Z
Wechsler
B
B
Piette
J C
JC
Caillat-Zucman
S
S
D000818:Animals; D001528:Behcet Syndrome / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics
D015235:HLA-B Antigens