[Disseminated histoplasmosis caused by Histoplasma capsulatum with cerebral involvement occurring 13 years after the primary infection].
A 49-year-old man with disseminated histoplasmosis (pulmonary and central nervous system involvement) successfully treated with ketoconazole and fluconazole combination is reported. Histoplasma capsulatum infection of the central nervous system is extremely rare in France partly because the organism is not endemic. Oral treatment with newer triazoles may be useful for central nervous system histoplasmosis, but additional information is needed to establish their effectiveness.
Bérard
H
H
Service de Pneumologie, Hôpital de la Conception, Marseille.
Astoul
P
P
Frenay
C
C
Cuguillière
A
A
Cho
K
K
Boutin
C
C
D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis* / Q000188:drug therapy*; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000935:Antifungal Agents; D015725:Fluconazole; D007654:Ketoconazole