Localized reversible frameshift mutation in the flhA gene confers phase variability to flagellin gene expression in Campylobacter coli.
Phase variation of flagellin gene expression in Campylobacter coli UA585 was correlated with high-frequency, reversible insertion and deletion frameshift mutations in a short homopolymeric tract of thymine residues located in the N-terminal coding region of the flhA gene. Mutation-based phase variation in flhA may generate functional diversity in the host and environment.
Park
S F
SF
School of Biological Sciences, University of Surrey, Guildford, GU2 5XH, United Kingdom. s.park@surrey.ac.uk
Purdy
D
D
Leach
S
S
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D017000:Campylobacter coli / Q000235:genetics*; D005408:Flagellin / Q000235:genetics* / Q000378:metabolism; D016368:Frameshift Mutation; D015964:Gene Expression Regulation, Bacterial; D005816:Genetic Complementation Test; D014644:Genetic Variation; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D015398:Signal Transduction; D014158:Transcription, Genetic
D001426:Bacterial Proteins; C080688:FlhA protein, Bacteria; D008565:Membrane Proteins; D005408:Flagellin; C067138:flaA protein, bacteria; C416532:flaB flagellin