title: Operative treatment of heterotopic hip ossification in patients with coma after brain injury.
abstract: In 13 joints of 12 patients who sustained traumatic brain injury, heterotopic ossifications of the hip were surgically excised at an average of 15 months after the patients' recovery from coma. All of the patients were referred by neurologists of the postcoma unit who deemed surgery necessary to speed up the rehabilitation program of the patients. Before surgery, three patients were able to ambulate, whereas nine were not ambulatory. Eight hips were ankylosed, whereas five had a severe painful limitation of joint motion. All of the patients were checked at regular intervals after the operation, and the final followup averaged 38 months. In an attempt to prevent postoperative recurrence of ossification, 100 mg of indomethacin was administered daily after surgery for 6 weeks. At followup, 10 patients could ambulate, and two were able to sit in a wheelchair. Patients with poor neuromuscular control tended to lose part of their postoperative range of motion, and heterotopic periarticular ossification recurred in two of them (three hips). No correlation was found between recurrence and the time that elapsed from head injury to the operation, but old ossifications continued to show osteogenic activity at the histologic level.
authors.affiliation: Department of Orthopedic Surgery, University of Rome Tor Vergata, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Ippolito
authors.forename: R
authors.initials: R
authors.lastname: Formisano
authors.forename: R
authors.initials: R
authors.lastname: Caterini
authors.forename: P
authors.initials: P
authors.lastname: Farsetti
authors.forename: F
authors.initials: F
authors.lastname: Penta
mesh_terms: D000293:Adolescent; D000328:Adult; D000844:Ankylosis / Q000601:surgery; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001930:Brain Injuries / Q000150:complications*; D003128:Coma / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006621:Hip Joint / Q000601:surgery*; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007592:Joint Diseases / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000150:complications; D009999:Ossification, Heterotopic / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D011788:Quality of Life; D016059:Range of Motion, Articular; D020127:Recovery of Function; D012008:Recurrence; D016138:Walking / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin