Peripheral progenitor cells (CFU-GM, BFU-E, CD34) are increased in untreated chronic lymphocyte leukemia patients: stage B and C display a particularly high CD34+ cell count.
No treatment has proved its efficiency in CLL. Autologous transplantation is now under consideration for the youngest patients. We assayed progenitor cells (CFU-GM, BFU-E, CD34) in the peripheral blood of 28 untreated CLL patients and found an increase of all these progenitors in CLL compared to controls. There was no statistical difference between stage A versus stages B and C for CFU-GM and BFU-E. In contrast, CD34 cells were higher in stages B and C as compared to stage A. This finding could be explained by a high number of circulating clonal cells in advanced stages of the disease.
Berger
M
M
Secteur d'Etude en HEMatopoïese, laboratoire d'Hématologie, Clermont-Ferrand, France.
Rapatel
C
C
Boiret
N
N
Halle
P
P
Kanold
J
J
Mareynat
G
G
Tournilhac
O
O
Albuisson
E
E
Bonhomme
J
J
Deméocq
F
F
Travade
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis; D003114:Colony-Forming Units Assay; D018450:Disease Progression; D015672:Erythroid Precursor Cells; D005260:Female; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood* / Q000473:pathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
D018952:Antigens, CD34