title: Implanted tumor growth is suppressed and survival is prolonged in sixty percent of food-restricted mice.
abstract: To examine the effect of food restriction on immune functions in the tumor-bearing state, mice were divided into a control group (fed 5.0 g diet/d; 71 kJ/d) and a 60% food-restricted group (fed 3.0 g diet/d; 43 kJ/d) at 8-wk of age, and 4 wk later, L1210 tumor cells were inoculated intradermally. In the food-restricted mice, tumor growth was significantly suppressed, and mean survival time after the tumor inoculation was prolonged (P < 0.05). The plasma concentrations of two antitumor cytokines, interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha), were greater in the food-restricted group before tumor inoculation (P < 0. 05). Furthermore, the food-restricted mice had significantly higher plasma levels of IFN-gamma and TNF-alpha after tumor inoculation, although the treatment significantly increased these cytokine levels in both groups. Splenic natural killer cell cytotoxicity was also higher in the tumor-bearing food-restricted mice than in controls (P < 0.05). Food-restricted mice have strong antitumor immunity, and as a result, tumor growth is suppressed and survival time is prolonged in these mice.
authors.affiliation: Department of Applied Biological Chemistry, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Matsuzaki
authors.forename: R
authors.initials: R
authors.lastname: Yamaji
authors.forename: K
authors.initials: K
authors.lastname: Kiyomiya
authors.forename: M
authors.initials: M
authors.lastname: Kurebe
authors.forename: H
authors.initials: H
authors.lastname: Inui
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D005508:Food Deprivation; D007371:Interferon-gamma / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D007939:Leukemia L1210 / Q000276:immunology*; D008297:Male; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma