title: N2 and P3b components of the event-related potential in students at risk for psychosis.
abstract: The N2 and P3b components of event-related potentials (ERPs) were studied in students who were identified as being at high risk for psychosis on the basis of their scores on the Chapman Psychosis Proneness Scales (PPS). The Magical Ideation subscale (MIS), the Perceptual Aberration subscale (PABS), and the Social Anhedonia subscale (SAS) were administered to 2,022 undergraduate university students. To determine if there were any relationships between these psychometric instruments and electrophysiological measures, 40 high-risk students were compared with 40 age- and gender-matched control students using auditory ERPs obtained from three midline electrodes (Fz, Cz, Pz) in a standard oddball paradigm. N2 (rare stimuli) and N2b latencies were significantly longer in the high-risk than in the control subjects, and the high-risk group also evidenced significantly smaller amplitude of the P3b component. No significant correlations between scores on the PPS or its three subscales and the amplitudes or latencies of the P3b or N200 component were found. These findings suggest that the N2 and P3b ERP components might serve as trait markers for psychosis and that individuals psychometrically identified as being at high risk for psychosis have deficits in the maintenance of attention and in decision-making.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, University of the Ryukyus, Uehara, Okinawa, Japan. npiyarat@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Nuchpongsai
authors.forename: H
authors.initials: H
authors.lastname: Arakaki
authors.forename: P
authors.initials: P
authors.lastname: Langman
authors.forename: C
authors.initials: C
authors.lastname: Ogura
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001288:Attention; D015415:Biomarkers; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D003657:Decision Making; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005072:Evoked Potentials, Auditory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D018570:Risk Assessment
chemical_list: D015415:Biomarkers