A giant cell angiofibroma involving 6q.
Giant cell angiofibroma, a recently proposed new clinicopathological entity, arises exclusively in the orbit in adults and histologically exhibits features intermediate between those of giant cell fibroblastoma and solitary fibrous tumor. In a typical case of giant cell angiofibroma, abnormalities of chromosome 6 with a common pattern involving 6q13 were detected together with various other chromosomal aberrations. To our knowledge, this is the first reported case of giant cell angiofibroma demonstrating chromosomal abnormalities.
Sonobe
H
H
Department of Pathology, Kochi Medical School, Japan.
Iwata
J
J
Komatsu
T
T
Fukushima
A
A
Hayashi
N
N
Moriki
T
T
Shimizu
K
K
Ohtsuki
Y
Y
D018322:Angiofibroma / Q000235:genetics* / Q000473:pathology; D018952:Antigens, CD34 / Q000032:analysis; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D005142:Eyelid Neoplasms / Q000235:genetics* / Q000473:pathology; D005870:Giant Cell Tumors / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014746:Vimentin / Q000032:analysis
D018952:Antigens, CD34; D014746:Vimentin