title: Loss of atheroprotective effect of estradiol in immunodeficient mice.
abstract: Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.
authors.affiliation: INSERM U397, Institut L. Bugnard, Toulouse, France.
authors.forename: R
authors.initials: R
authors.lastname: Elhage
authors.forename: S
authors.initials: S
authors.lastname: Clamens
authors.forename: C
authors.initials: C
authors.lastname: Reardon-Alulis
authors.forename: G S
authors.initials: GS
authors.lastname: Getz
authors.forename: C
authors.initials: C
authors.lastname: Fievet
authors.forename: A
authors.initials: A
authors.lastname: Maret
authors.forename: J F
authors.initials: JF
authors.lastname: Arnal
authors.forename: F
authors.initials: F
authors.lastname: Bayard
mesh_terms: D000818:Animals; D001011:Aorta / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics* / Q000276:immunology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004958:Estradiol / Q000627:therapeutic use*; D005260:Female; D008214:Lymphocytes / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D010641:Phenotype; D019895:Transposases / Q000235:genetics / Q000378:metabolism
chemical_list: D001057:Apolipoproteins E; D004268:DNA-Binding Proteins; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2; D004958:Estradiol; D019895:Transposases