title: Biological features of the new A2G--adr mouse mutant with abnormal muscle function.
abstract: A new mouse mutant (A2G-adr) with abnormal muscle function is described and has been compared with the 129 Re dystrophic mouse. The mutation, which is due to an autosomal gene defect, results in myotonic-like spasms, progressive muscle weakness and a reduced lifespan. Affected animals were consistently lighter than normal littermates; comparison of organ weights and organ-to-bodyweight ratios indicated a slower growth rate in the mutants.
authors.affiliation: Department of Biochemistry, Guy's Hospital Medical School, London, UK.
authors.forename: W J
authors.initials: WJ
authors.lastname: Watkins
authors.forename: D C
authors.initials: DC
authors.lastname: Watts
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D001921:Brain / Q000033:anatomy & histology; D005260:Female; D006321:Heart / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000033:anatomy & histology* / Q000502:physiology*; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology*; D009132:Muscles / Q000033:anatomy & histology*; D009929:Organ Size / Q000235:genetics