title: Real-time three-dimensional echocardiography for measurement of left ventricular volumes.
abstract: Left ventricular (LV) volumes are important prognostic indexes in patients with heart disease. Although several methods can evaluate LV volumes, most have important intrinsic limitations. Real-time 3-dimensional echocardiography (RT3D echo) is a novel technique capable of instantaneous acquisition of volumetric images. The purpose of this study was to validate LV volume calculations with RT3D echo and to determine their usefulness in cardiac patients. To this end, 4 normal subjects and 21 cardiac patients underwent magnetic resonance imaging (MRI) and RT3D echo on the same day. A strong correlation was found between LV volumes calculated with MRI and with RT3D echo (r = 0.91; y = 20.1 + 0.71x; SEE 28 ml). LV volumes obtained with MRI were greater than those obtained with RT3D echo (126 +/- 83 vs 110 +/- 65 ml; p = 0.002), probably due to the fact that heart rate during MRI acquisition was lower than that during RT3D echo examination (62 +/- 11 vs 79 +/- 16 beats/min; p = 0.0001). Analysis of intra- and interobserver variability showed strong indexes of agreement in the measurement of LV volumes with RT3D echo. Thus, LV volume measurements with RT3D echo are accurate and reproducible. This technique expands the use of ultrasound for the noninvasive evaluation of cardiac patients and provides a new tool for the investigational study of cardiovascular disease.
authors.affiliation: Cardiology Branch, the Laboratory of Cardiac Energetics, and the Laboratory of Animal Medicine and Surgery, National Heart, Lung, and Blood Institute, the Center for Information Technology, Bethesda, Maryland, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Schmidt
authors.forename: C J
authors.initials: CJ
authors.lastname: Ohazama
authors.forename: K O
authors.initials: KO
authors.lastname: Agyeman
authors.forename: R Z
authors.initials: RZ
authors.lastname: Freidlin
authors.forename: M
authors.initials: M
authors.lastname: Jones
authors.forename: J M
authors.initials: JM
authors.lastname: Laurienzo
authors.forename: C L
authors.initials: CL
authors.lastname: Brenneman
authors.forename: A E
authors.initials: AE
authors.lastname: Arai
authors.forename: O T
authors.initials: OT
authors.lastname: von Ramm
authors.forename: J A
authors.initials: JA
authors.lastname: Panza
mesh_terms: D000328:Adult; D000368:Aged; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology; D002306:Cardiac Volume / Q000502:physiology*; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging / Q000503:physiopathology; D003199:Computer Systems; D004452:Echocardiography; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology; D011446:Prospective Studies; D012016:Reference Values; D016277:Ventricular Function, Left / Q000502:physiology