[Association of TAP1/TAP2 gene polymorphism with inflammatory urogenital diseases combined with joint diseases].
OBJECTIVE
To study association of TAP1/TAP2 gene polymorphism with urogenital infections combined with joint lesions.


METHODS
Of 139 patients examined 45 ones had inflammation caused by Chlamydia trachomatis (17 had joint disease), 42 had Mycoplasma hominis infection (joint lesions in 17 cases). Method of amplification was used on the basis of specific primers (ARMS).


RESULTS
Patients infected with C. trachomatis significantly more frequently had allele TAP1-02011 and TAP2-0201 (RR = 18.5, p < 0.01 and RR = 4.61, p < 0.05, respectively). Joint lesion in patients with chlamydial infection was associated with allele TAP1-02011 (RR = 11.92, p < 0.05). In mycoplasmosis association with joint lesions there is a significant link of joint syndrome with heterogeneous combination threonine/alanine in gene TAP2 position 565 (RR = 4.22, p < 0.05).


CONCLUSIONS
The findings can be used for predicting the joint syndrome development in patients with urogenital infection.
Sartakova
M L
ML
Konenkov
V I
VI
Shevchenko
A V
AV
Golovanova
O V
OV
Konenkova
L P
LP
Zonova
E V
EV
Korolev
M A
MA
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D026905:Amino Acid Transport Systems; D001170:Arthritis, Infectious / Q000150:complications / Q000235:genetics / Q000382:microbiology*; D002690:Chlamydia Infections / Q000150:complications / Q000235:genetics / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000235:genetics* / Q000276:immunology; D017931:DNA Primers / Q000737:chemistry; D004269:DNA, Bacterial / Q000032:analysis; D005095:Exoribonucleases / Q000235:genetics*; D005260:Female; D052776:Female Urogenital Diseases / Q000150:complications / Q000235:genetics / Q000382:microbiology*; D005656:Fungal Proteins / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D052801:Male Urogenital Diseases; D009175:Mycoplasma Infections / Q000150:complications / Q000235:genetics / Q000382:microbiology; D019535:Mycoplasma hominis / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D029701:Saccharomyces cerevisiae Proteins
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D026905:Amino Acid Transport Systems; D017931:DNA Primers; D004269:DNA, Bacterial; D005656:Fungal Proteins; D005819:Genetic Markers; D029701:Saccharomyces cerevisiae Proteins; C429825:TAT2 protein, S cerevisiae; C071692:TAP2 protein, human; D005095:Exoribonucleases