A case of sustained massive gabapentin overdose without serious side effects.
Gabapentin is an antiepileptic agent that is indicated for use as adjunctive therapy for partial seizures. It has a relatively benign side effect profile, but little data exists on massive overdoses with this agent. The authors present a case of a patient who received a massive overdose of this agent but suffered no clinically significant toxicity.
Verma
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Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
St Clair
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Radtke
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D000085:Acetates / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids; D062787:Drug Overdose; D004828:Epilepsies, Partial / Q000150:complications / Q000188:drug therapy*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D051437:Renal Insufficiency / Q000150:complications / Q000378:metabolism / Q000628:therapy; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D000077206:Gabapentin