title: A meta-analysis of risk estimates for prostate cancer related to tire and rubber manufacturing operations.
abstract: Studies investigating the association between prostate cancer and exposure to the tire and rubber manufacturing environment have reported weak and inconsistent results. A meta-analysis of nine cohort studies that used standard mortality ratios and three case-control studies that used odds ratios was conducted. The pooled results from the nine cohort studies showed a standard mortality ratio of 101 (95% confidence interval [CI] = 93,110), whereas the pooled results from the three case-control studies showed on odds ratio of 1.10 (95% CI = 0.94, 1.29). The standard mortality ratios were converted to odds ratios by dividing by 100. The overall pooled risk estimate from all 12 studies was 1.03 (95% CI = 0.96, 1.11). The conclusion of this meta-analysis is that work exposure in a rubber and tire manufacturing environment does not result in an increased risk of prostate cancer.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Stewart
authors.forename: L K
authors.initials: LK
authors.lastname: Dennis
authors.forename: D V
authors.initials: DV
authors.lastname: Dawson
authors.forename: M I
authors.initials: MI
authors.lastname: Resnick
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D006801:Humans; D007221:Industry; D008297:Male; D008420:Manufactured Materials; D008875:Middle Aged; D016273:Occupational Exposure; D016272:Occupational Health; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000209:etiology*; D018570:Risk Assessment; D012408:Rubber
chemical_list: D012408:Rubber