Ciprofloxacin-induced bone marrow depression.
Ciprofloxacin, a broad-spectrum fluoroquinolone antibacterial agent, is generally considered to be a safe drug. However, occasionally it may have life-threatening complications. Two instances of bone marrow failure following use of ciprofloxacin are reported. In one case, the bone marrow reverted to normal following withdrawal of the drug. In the other case, the patient succumbed to irreversible bone marrow depression leading to severe thrombocytopenia and uncontrolled bleeding. This could have been an idiosyncratic reaction.
Dutta
T K
TK
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Badhe
B A
BA
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002452:Cell Count; D002939:Ciprofloxacin / Q000009:adverse effects*; D004906:Erythrocyte Count; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D010198:Pancytopenia / Q000139:chemically induced*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin