title: Quitting chew: results from a randomized trial using nicotine patches.
abstract: The authors examined the efficacy of transdermal nicotine replacement for cessation in 410 adult nonsmoking chewing tobacco users. Participants were randomly assigned to 6 weeks of 15-mg nicotine patch plus behavioral treatment or placebo patch plus behavioral treatment. All participants received the same behavioral treatment of 2 pharmacy visits, 2 support calls, and self-help materials. At 6 months after treatment, biochemically confirmed point-prevalence rates (no chewing in the last 7 days) in the active (38%) and placebo (34%) groups were high and not significantly different. The difference in relapse (no chewing for 7 consecutive days) between the active patch group (33%) and placebo group (48%) was significant at 6 months (p = .003). Nicotine dependence and age predicted nonrelapse at 6 months. The results suggest that nicotine replacement may improve chewers' chances of abstinence.
authors.affiliation: Stanford University School of Medicine, California, USA. howard@SCRDP.Stanford.edu
authors.forename: B
authors.initials: B
authors.lastname: Howard-Pitney
authors.forename: J D
authors.initials: JD
authors.lastname: Killen
authors.forename: S P
authors.initials: SP
authors.lastname: Fortmann
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D012008:Recurrence; D012463:Saliva / Q000737:chemistry; D020340:Tobacco Use Cessation / Q000379:methods* / Q000523:psychology
chemical_list: D018722:Nicotinic Agonists; D009538:Nicotine