title: Antiplatelet actions of aporphinoids from Formosan plants.
abstract: Seventeen aporphines were tested for antiplatelet activity. L-(+)-hemovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5'-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 microM against AA-induced platelet aggregation.
authors.affiliation: Tajen Institute of Technology, Ping Tung Hsien, Taiwan.
authors.forename: Y C
authors.initials: YC
authors.lastname: Chia
authors.forename: K S
authors.initials: KS
authors.lastname: Chen
authors.forename: Y L
authors.initials: YL
authors.lastname: Chang
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000818:Animals; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D001060:Aporphines; D010975:Platelet Aggregation Inhibitors; C081279:aporphine