title: Determinants of the first decade of bone loss after menopause at spine, hip and radius.
abstract: This study documented bone loss at three different sites in the early postmenopausal period, and examined potential predictors. Forty-three women underwent repeated measurements of bone density at the lumbar spine, proximal femur and distal radius for up to 14 years. Individual rates of bone loss were calculated for the spine and hip; for radial trabecular bone, rates were calculated separately for two time periods, earlier and later after menopause. In the spine and radius, initially high rates of loss diminished with time after menopause. No positive correlations for bone loss were found between the three sites, suggesting that faster than average bone loss was specific to individual bones. High body mass index (BMI) was significantly protective against fast bone loss at the spine and radius; in the spine, each unit increase in BMI was associated with a approximately 5% reduction in the rate of bone loss. Of the other variables measured (maximum oxygen consumption, lean body mass, fat mass, mean psoas muscle area at the L3 level, hand grip strength as well as anthropometry) only bone densitometry was sufficiently predictive to help guidance on hormone replacement or other prophylactic therapy. The data suggest that the known relationship between excessive leanness and risk of osteoporosis and vertebral fracture after menopause might in part be due to fast post-menopausal bone loss. Because bulk of psoas muscle was associated with low spine loss rates, the data also support a role for applied muscular loading in local maintenance of bone density.
authors.affiliation: University of Cambridge Department of Medicine, Northwick Park Hospital, UK. j.reeve@mrc-bsu.cam.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Reeve
authors.forename: J
authors.initials: J
authors.lastname: Walton
authors.forename: L J
authors.initials: LJ
authors.lastname: Russell
authors.forename: M
authors.initials: M
authors.lastname: Lunt
authors.forename: R
authors.initials: R
authors.lastname: Wolman
authors.forename: R
authors.initials: R
authors.lastname: Abraham
authors.forename: J
authors.initials: J
authors.lastname: Justice
authors.forename: A
authors.initials: A
authors.lastname: Nicholls
authors.forename: B
authors.initials: B
authors.lastname: Wardley-Smith
authors.forename: J R
authors.initials: JR
authors.lastname: Green
authors.forename: A
authors.initials: A
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D001835:Body Weight; D015519:Bone Density / Q000502:physiology*; D003720:Densitometry / Q000379:methods; D005260:Female; D005269:Femur / Q000502:physiology; D006615:Hip / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D015675:Osteocalcin / Q000652:urine; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology* / Q000652:urine; D011884:Radius / Q000503:physiopathology; D013131:Spine / Q000503:physiopathology; D013997:Time Factors
chemical_list: D015675:Osteocalcin