title: Frequency dependence of ultrasonic backscatter from human trabecular bone: theory and experiment.
abstract: A model describing the frequency dependence of backscatter coefficient from trabecular bone is presented. Scattering is assumed to originate from the surfaces of trabeculae, which are modeled as long thin cylinders with radii small compared with the ultrasonic wavelength. Experimental ultrasonic measurements at 500 kHz, 1 MHz, and 2.25 MHz from a wire target and from trabecular bone samples from human calcaneus in vitro are reported. In both cases, measurements are in good agreement with theory. For mediolateral insonification of calcaneus at low frequencies, including the typical diagnostic range (near 500 kHz), backscatter coefficient is proportional to frequency cubed. At higher frequencies, the frequency response flattens out. The data also suggest that at diagnostic frequencies, multiple scattering effects on the average are relatively small for the samples investigated. Finally, at diagnostic frequencies, the data suggest that absorption is likely to be a larger component of attenuation than scattering.
authors.affiliation: U.S. Food and Drug Administration, Center for Devices and Radiological Health, Rockville, Maryland 20852, USA. kaw@cdrh.fda.gov
authors.forename: K A
authors.initials: KA
authors.lastname: Wear
mesh_terms: D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D006801:Humans; D008962:Models, Theoretical; D014465:Ultrasonics; D014463:Ultrasonography