Does the degree of penicillin susceptibility of Streptococcus pneumoniae affect the bactericidal activity of co-amoxiclav versus oral cephalosporins at physiological concentrations? An in vitro pharmacodynamic simulation.
An in vitro model simulating amoxicillin-clavulanic acid (co-amoxiclav) versus oral cephalosporin serum concentrations was used to explore activity over time against penicillin-susceptible and non-susceptible Streptococcus pneumoniae. Initial inoculum reduction > 4 log cfu/ml (>99.9%) was obtained with co-amoxiclav against both strains. Cefuroxime, cefpodoxime and cefaclor achieved a similar reduction against the susceptible strain, but no reduction against the non-susceptible strain.
Prieto
J
J
Microbiology Department, School of Medicine, Universidad Complutense, Madrid, Spain.
Giménez
M J
MJ
Balcabao
I P
IP
Gómez-Lus
M L
ML
Aguilar
L
L
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D013296:Streptococcus pneumoniae / Q000187:drug effects*
D002511:Cephalosporins; D010406:Penicillins; D019980:Amoxicillin-Potassium Clavulanate Combination