title: Experimental common cold increases mucosal output of eotaxin in atopic individuals.
abstract: BACKGROUND
  In view of recent observations demonstrating that rhinovirus infections are associated with increased local activity of eosinophils, we hypothesized that eotaxin, a selective eosinophil chemoattractant, may be involved in eosinophil recruitment/activation in common cold infections.
  
  
  METHODS
  Twenty-three patients with seasonal allergic rhinitis were inoculated with human rhinovirus 16 (HRV 16) outside the pollen season. Sequential diluent and allergen (10(3) SQ-U) challenges, each followed by nasal lavage, were carried out about 3 months before and 4 days after virus inoculation.
  
  
  RESULTS
  Seventeen patients developed common cold and were further analyzed. Lavage fluid levels of eotaxin were increased at the height of active common cold (day 4 after inoculation) both at baseline (after diluent challenge) (P<0.01) and acutely after allergen challenge (P<0.05).
  
  
  CONCLUSIONS
  Common cold symptoms after nasal HRV 16 inoculation are associated with increased nasal mucosal output of eotaxin, suggesting that this chemokine is partly responsible for recruitment/activation of airway mucosal eosinophils in common cold infections.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Greiff
authors.forename: M
authors.initials: M
authors.lastname: Andersson
authors.forename: E
authors.initials: E
authors.lastname: Andersson
authors.forename: M
authors.initials: M
authors.lastname: Linden
authors.forename: S
authors.initials: S
authors.lastname: Myint
authors.forename: C
authors.initials: C
authors.lastname: Svensson
authors.forename: C G
authors.initials: CG
authors.lastname: Persson
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D054413:Chemokine CCL11; D019742:Chemokines, CC; D003139:Common Cold / Q000378:metabolism*; D016207:Cytokines / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000502:physiology; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases