Breakage of B cell tolerance and autoantibody production in anti-erythrocyte transgenic mice.
In summary, there are two pathways for activation of peritoneal B-1 cells in HL mice: T cell-dependent and T cell-independent pathways. In both pathways, IL-10 is suggested to play an important role (Fig. 1). We have not yet known what type of cells secrete IL-10 by and whether other soluble factors are involved in each pathway. These questions are to be elucidated by further studies on HL mice.
Nisitani
S
S
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Honjo
T
T
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001402:B-Lymphocytes / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D008822:Mice, Transgenic
D001323:Autoantibodies