title: Inhibitory effects of citrus essential oils and their components on the formation of N-nitrosodimethylamine.
abstract: Twenty-eight kinds of citrus essential oils and their components were studied for inhibitory effects on the formation of N-nitrosodimethylamine (NDMA). The reaction mixture consisted of dimethylamine and sodium nitrite adjusted at pH 3.6, in addition to essential oils and an emulsifying agent. The quantification was determined by high-performance liquid chromatography monitored at 220 nm. All of the essential oils inhibited the formation of NDMA in the range of 20-85%. The oils of ujukitsu (Citrus ujukitsu Hort. ex Shirai), yuzu (C. junos Tanaka), mochiyu (C. inflata Hort. ex Tanaka), and ponkan (C. reticulata Blanco cv. F-2426) inhibited the formation of NDMA much more effectively than other citrus oils. The inhibitory proportions of components of citrus essential oils such as myrcene, alpha-terpinene, and terpinolene were as high as 80%.
authors.affiliation: Department of Bioresources Science, Faculty of Agriculture, Kochi University, B-200 Monobe, Nankoku, Kochi 783-8502, Japan. sawamura@cc.kochi-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Sawamura
authors.forename: S H
authors.initials: SH
authors.lastname: Sun
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: J
authors.initials: J
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Ukeda
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002957:Citrus / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D009603:Nitroso Compounds / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009822:Oils, Volatile / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D016588:Anticarcinogenic Agents; D009603:Nitroso Compounds; D009822:Oils, Volatile; D010938:Plant Oils; C008651:4-nitrosodimethylaniline