Anti-inflammatory cytokine response and clinical outcome in acute pancreatitis.
OBJECTIVE
To test the hypothesis that elevated interleukin (IL)-10 plasma concentration relative to IL-6 and IL-8 in patients with acute pancreatitis is associated with improved clinical outcome.


METHODS
Case series.


METHODS
University hospital surgical and intensive care unit.


METHODS
Patients with mild (n = 18) and severe (n = 14) acute pancreatitis were recruited within 12 hrs of admission and studied for 5 days.


METHODS
None.


RESULTS
The plasma concentration of IL-10 was significantly elevated in patients with severe pancreatitis during the 5 days and especially so in those who died compared with survivors on day 5 (p <.03). The ratio of IL-10/IL-6 was decreased in patients with severe pancreatitis on day 5 (p < .01). There was a significant decrease in the ratio of IL-10/IL-8, but not of IL-10/IL-6, during the first 5 days (p < .014).


CONCLUSIONS
The findings are consistent with the hypothesis that an increase in plasma IL-10 relative to IL-6 or IL-8 is associated with improved clinical outcome.
Simovic
M O
MO
Pancreatitis Research Group, Department of Surgery, Faculty of Medicine and Health Science, University of Auckland, New Zealand.
Bonham
M J
MJ
Abu-Zidan
F M
FM
Windsor
J A
JA
D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D010195:Pancreatitis / Q000145:classification / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome
D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10