title: Distinct prefrontal activations in processing sequence at the sentence and script level: an fMRI study.
abstract: Neuropsychological studies have shown that the prefrontal cortex is important in planning and monitoring everyday behaviour. In this study, using functional magnetic resonance imaging (fMRI), we investigated whether specific prefrontal regions are involved in processing a sequence of actions. Subjects were required to perform two different tasks: Script-event order and Sentence-word order. Script sequence and word sequence processing were found to activate partially overlapping areas which are known to be implicated in language processing. In addition, the Script-task activated a large area in the dorsolateral prefrontal cortex (Brodmann area 6 and 8, BA 6 and 8), in both the left and right hemispheres, as well as the left supplementary motor area and left angular gyrus (BA 39). Our results suggest that these prefrontal areas may be more specifically involved in the process of analysing sequential links in the action domain.
authors.affiliation: INSERM U289, Hôpital de la Salpêtrière, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Crozier
authors.forename: A
authors.initials: A
authors.lastname: Sirigu
authors.forename: S
authors.initials: S
authors.lastname: Lehéricy
authors.forename: P F
authors.initials: PF
authors.lastname: van de Moortele
authors.forename: B
authors.initials: B
authors.lastname: Pillon
authors.forename: J
authors.initials: J
authors.lastname: Grafman
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: B
authors.initials: B
authors.lastname: Dubois
authors.forename: D
authors.initials: D
authors.lastname: LeBihan
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D011340:Problem Solving / Q000502:physiology; D011932:Reading; D012660:Semantics