title: Drug induced blistering and the plastic surgeon: a case of amitriptyline induced skin necrosis.
abstract: We report a case of patchy full thickness skin necrosis following drug overdose with amitriptyline, that required excision and split skin grafting. To our knowledge this is the first report of amitriptyline induced skin necrosis that can be definitively attributed to this drug. The implications of drug related skin necrosis for the surgeon are discussed.
authors.affiliation: Department of Burns and Plastic Surgery, The Royal Victoria Hospital, Belfast, UK.
authors.forename: B J
authors.initials: BJ
authors.lastname: Fogarty
authors.forename: K
authors.initials: K
authors.lastname: Khan
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000506:poisoning*; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009336:Necrosis; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D016038:Skin Transplantation
chemical_list: D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline