title: In search of new chemical entities with spermicidal and anti-HIV activities.
abstract: Several compounds belonging to 2-isoxazolines (4,5a-c), isoxazoles (3,6a-c) and 1-amino-1-cycloalkyl-2-substituted phenyl ethanes (16-18,a-e) have been synthesised and found to possess spermicidal activity. Out of these a couple of compounds (5a and 6a) exhibit anti-HIV activity.
authors.affiliation: Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: L K
authors.initials: LK
authors.lastname: Bajpai
authors.forename: S
authors.initials: S
authors.lastname: Batra
authors.forename: A P
authors.initials: AP
authors.lastname: Bhaduri
authors.forename: J P
authors.initials: JP
authors.lastname: Maikhuri
authors.forename: G
authors.initials: G
authors.lastname: Gupta
authors.forename: J D
authors.initials: JD
authors.lastname: Dhar
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002478:Cells, Cultured; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D013089:Spermatocidal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D013089:Spermatocidal Agents