Procedural and late outcomes following MULTI-LINK DUET coronary stent deployment.
The MULTI-LINK DUET is the next generation MULTI-LINK stent with modified strut geometry. Safety and efficacy of the MULTI-LINK DUET were evaluated in a prospective multicenter registry and were compared with prior MULTI-LINK stent experience from the ASCENT randomized trial. A total of 270 patients received 302 MULTI-LINK DUET stents and were evaluated using a composite primary end point of major cardiac events (death, Q-wave and non-Q-wave myocardial infarction, and requirement for coronary revascularization) attributable to the target stenosis cumulative to 30 days following enrollment. Quantitative coronary angiography was performed at a mean follow-up of 6 +/- 2 (+/-SD) months. No difference in primary end point or in angiographic restenosis to 6 months was observed between MULTI-LINK DUET and MULTI-LINK experiences. The MULTI-LINK DUET demonstrated improved device and procedural success, less postprocedural in-stent stenosis, larger postprocedural minimal lumen diameter, and fewer postprocedural marginal dissections compared with the MULTI-LINK stent. Multivariate regression modeling identified stent length, diabetes mellitus, poststent minimal lumen diameter, lesion eccentricity, and current smoking as independent predictors of in-stent restenosis. Thus, the MULTI-LINK DUET Registry demonstrates enhanced procedural performance with clinical and angiographic outcomes similar to those previously observed for the MULTI-LINK stent in the ASCENT randomized trial.
Kereiakes
D J
DJ
Linder Research Center, Cincinnati, Ohio 45219, USA. lindner@healthhall.com
Midei
M
M
Hermiller
J
J
O'Shaughnessy
C
C
Schlofmitz
R
R
Yakubov
S
S
Fink
S
S
Hu
F
F
Nishimura
N
N
Sievers
M
M
Valentine
M E
ME
Broderick
T
T
Lansky
A
A
Moses
J
J
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D002423:Cause of Death; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D019544:Equipment Failure Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality; D011446:Prospective Studies; D011474:Prosthesis Design; D011859:Radiography; D015607:Stents; D015996:Survival Rate; D016896:Treatment Outcome