title: [Intestinal polyposis in APC knockout mice: mechanism of tumorigenesis and chemotherapy].
authors.affiliation: Laboratory of Biomedical Genetics, Graduate School Pharmaceutical Science, University of Tokyo.
authors.forename: M M
authors.initials: MM
authors.lastname: Taketo
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000188:drug therapy / Q000235:genetics; D000818:Animals; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D004268:DNA-Binding Proteins / Q000235:genetics; D004195:Disease Models, Animal; D005663:Furans / Q000627:therapeutic use; D006579:Heterozygote; D007527:Isoenzymes / Q000494:pharmacology / Q000502:physiology; D019656:Loss of Heterozygosity; D051379:Mice; D018345:Mice, Knockout; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology / Q000502:physiology; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D004268:DNA-Binding Proteins; D005663:Furans; D007527:Isoenzymes; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; C102563:3-(3,4-difluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2(5H)-furanone; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases