title: Is episodic obsessive compulsive disorder bipolar? A report of four cases.
abstract: Several reports have noted cases of OCD which were unusual in showing an abrupt remission. We report longitudinal clinical observation of four cases of acute onset OCD without major depression through a variety of treatments. These patients had prominent feelings of shamefulness; compared to patients with typical OCD they were ill for months rather than years and were older. Two had previous episodes of psychiatric illness with full recovery. Full and persistent recovery occurred in response to lithium or an acute course of ECT but not to tricyclic or SSRI antidepressants. The generalizability of these observations is limited by its uncontrolled nature and the small numbers. The courses observed were consistent with episodic OCD as a possible expression of bipolar disorder and consideration of corresponding treatments. This perspective offers a new rationale for reported observations of remissions of acute onset OCD in response to lithium without lithium effectiveness for typical OCD.
authors.affiliation: Department of Psychiatry, Saint Louis University School of Medicine, MO 63104, USA. ectdoc@pol.net
authors.forename: C M
authors.initials: CM
authors.lastname: Swartz
authors.forename: W W
authors.initials: WW
authors.lastname: Shen
mesh_terms: D000208:Acute Disease; D000328:Adult; D017668:Age of Onset; D000928:Antidepressive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000523:psychology*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D016651:Lithium Carbonate