Peptide hormone precursor processing: getting sorted?
Processing of proproteins to biologically active peptides and, in the case of peptide hormones and neuropeptides, their sorting to granules of the regulated secretory pathway, requires the concerted action of a cascade of enzymes and chaperones. The purpose of this review is to summarize the recent emerging knowledge of how these molecules affect specific endocrine systems. This has come about through the study of gene knockout mice as well as endocrinopathies resulting from mutated genes in humans.
Canaff
L
L
Department of Medicine, McGill University, Montreal, Quebec, Canada.
Bennett
H P
HP
Hendy
G N
GN
D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism; D006728:Hormones / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D018832:Molecular Chaperones / Q000378:metabolism; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000378:metabolism; D051859:Neuroendocrine Secretory Protein 7B2; D010455:Peptides / Q000235:genetics* / Q000378:metabolism; D010907:Pituitary Hormones / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
D006728:Hormones; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins; D051859:Neuroendocrine Secretory Protein 7B2; D010455:Peptides; D010907:Pituitary Hormones; D011498:Protein Precursors; C497678:SCG5 protein, human; D002268:Carboxypeptidases; D010450:Endopeptidases; D043423:Carboxypeptidase H