title: [Stress ulcer prophylaxis in the intensive care unit].
abstract: In the early years of intensive care a stress ulcer related bleeding, occurring in 20-30% of the IC population, became recognized as a significant cause of morbidity and mortality. Due to improved intensive care medicine (including adequate early resuscitation, analgesia, sedation) the incidence of stress ulcer-related bleeding in the IC has decreased markedly. Without pharmacological prophylaxis incidences ranging from 0.6 to 6% were reported. It is not recommended to apply stress ulcer prophylaxis on a routine basis, it should be reserved for patients with an increased risk of a stress ulcer-related bleeding. In patients with neurotrauma, severe burn, recent peptic ulcer or bleeding and those with coagulopathy prophylaxis with ranitidine is advised.
authors.affiliation: Academisch Ziekenhuis Vrije Universiteit, afd. Acute Interne Geneeskunde, Amsterdam.
authors.forename: C W
authors.initials: CW
authors.lastname: de Fijter
authors.forename: R J
authors.initials: RJ
authors.lastname: Strack van Schijndel
authors.forename: L G
authors.initials: LG
authors.lastname: Thijs
mesh_terms: D000897:Anti-Ulcer Agents / Q000008:administration & dosage; D003422:Critical Care / Q000379:methods*; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units / Q000639:trends; D009426:Netherlands / Q000453:epidemiology; D010438:Peptic Ulcer Hemorrhage / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011899:Ranitidine / Q000008:administration & dosage; D012307:Risk Factors
chemical_list: D000897:Anti-Ulcer Agents; D011899:Ranitidine