[(2E)-4-hydroxy-2-nonenal--an active component of a new natural antimicrobial substance].
A mixture of water-soluble oxidation products of Sardinops melanosticta sardine oil was found to contain (2E)-4-hydroxy-2-nonenal. This was isolated by column chromatography on silica gel and reversed-phase HPLC. Its structure was elucidated by physicochemical methods. The activity of (2E)-4-hydroxy-2-nonenal against test cultures of Escherichia coli, Staphylococcus aureus, and Bacillus subtilis was about 20% of the total antimicrobial activity of the preparation.
Rybin
V G
VG
Pacific Research Fishery Center, Vladivostok, Russia. root@tinro.marine.su
Kuklev
D V
DV
Byval'tseva
T M
TM
Blinov
Iu G
IuG
Akulin
V N
VN
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004926:Escherichia coli / Q000187:drug effects; D005395:Fish Oils / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D005395:Fish Oils; C027576:4-hydroxy-2-nonenal