Major histocompatibility complex class II antigen presentation in Hodgkin's disease.
The malignant cells in Hodgkin's disease (HD), commonly referred to as Hodgkin and Reed-Sternberg (HRS) cells, express major histocompatibility complex (MHC) class II molecules and, like "professional" antigen-presenting cells (APCs), different accessory or costimulatory molecules which can provide an additional activation signal to T cells. Despite expressing the key effector molecules of APCs, HRS cells fail to evoke an effective T cell response in vivo. Previous work addressing this paradox has shown that in a large proportion of HRS cells MHC class II molecules present the non-immunogenic MHC class II-associated invariant chain peptide (CLIP). The inability of many HRS cells to present MHC class II-associated antigenic peptides to surrounding helper T lymphocytes could explain how these malignant APCs can thrive in a hostile environment of apparently immunocompetent cells.
Bosshart
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Balgrist University Hospital, Research Department, Zurich, Switzerland. hbosshar@balgrist.unizh.ch
D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000502:physiology; D015703:Antigens, CD / Q000032:analysis; D051940:B7-2 Antigen; D019013:CD40 Antigens / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000032:analysis; D016539:Reed-Sternberg Cells / Q000473:pathology
D015703:Antigens, CD; D051940:B7-2 Antigen; D019013:CD40 Antigens; C497964:CD86 protein, human; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins