[Universal cerebral mechanisms in the pathogenesis of paroxysmal states].
Paroxysmal disorders are conventionally divided into paroxysms of epileptic and nonepileptic origin. In spite of the different mechanisms of their development, paroxysmal states of different types have some similar clinical features: short duration of the disorders, frequent combination of emotional, motor and autonomic disorders during paroxysm, normal neurologic status between the attacks, possible positive reaction to anticoagulants. These facts allow to consider a "paroxysm" as a possible universal pathogenetic mechanism of brain's reaction to endogenic and exogenic stimulus. A comparative study of 4 types of paroxysmal states was performed: partial epileptic fits, attacks of paroxysmal dystonia, pseudofits, panic attacks. The elevation of general power of spontaneous electric activity, an interhemispheric assymmetry of the power of theta-range, the reaction of hypersynchronization as the reply to 24-hours of sleep deprivation, the increase of the total amplitude of contingent negative deviation were general neurophysiologic characteristics of the states. "Readiness" of brain to the development of paroxysm was characterised by the dynamic elevation of the indices of spontaneous and evoked biologic activity mentioned above.
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Vorov'eva
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D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology; D016584:Panic Disorder / Q000150:complications; D010507:Periodicity; D012892:Sleep Deprivation; D013826:Theta Rhythm