title: Influence of microbial phytase and dietary calcium on the accumulation of lead in different organs of pigs.
abstract: The objective of this study was to investigate the influence of microbial phytase and calcium supplementation to diets for growing pigs on the retention of lead in the kidney, liver, muscle, brain, and bone (phalanx 1). The experiments were carried out with barrows over the body weight range from 17 to 50 kg. The average lead concentration of the diets was 1.45 mg/kg dry matter. Diets were prepared with or without a supplement of 800 units of microbial phytase. The calcium concentration in the diets was 6.53 or 13.4 g/kg dry matter. The addition of microbial phytase showed an increase of lead concentration in bone. By increasing the calcium concentration to 13.4 g/kg dry matter, it was possible to avoid the phytase-induced increase of lead retention in bone.
authors.affiliation: Institute of Animal Nutrition, Hohenheim University, Stuttgart, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Zacharias
authors.forename: H J
authors.initials: HJ
authors.lastname: Lantzsch
authors.forename: W
authors.initials: W
authors.lastname: Drochner
mesh_terms: D010832:6-Phytase / Q000494:pharmacology*; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D004032:Diet; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D013552:Swine; D014018:Tissue Distribution
chemical_list: D007854:Lead; D010832:6-Phytase; D002118:Calcium