title: Toxicologic considerations in the diagnosis of occupational asthma.
abstract: BACKGROUND
  The consideration of dose for chemicals inducing occupational asthma is examined from the point of view of a toxicologist. Two widely used chemicals in industry, toluene diisocyanate (TDI) and formaldehyde, are used as examples of agents that are formally recognized by OSHA to cause occupational asthma. The Permissible Exposure Limit (PEL) of OSHA and the Threshold Limit Value (TLV) of ACGIH for TDI are identical and are in the range of values for which occupational asthma has been reported in some workers. The narrow range of exposure values for TDI in studies of workers with and without asthma is discussed and correlated with the background concentration of TDI in the ambient atmosphere. For formaldehyde, the PEL and TLV, in contrast, offer a wide margin of safety for the inducement of occupational asthma.
  
  
  CONCLUSIONS
  From this disparity in exposure limits for TDI and formaldehyde, it is concluded that occupational exposure limits by agencies for specific chemicals do not provide a reliable indication of the concentration of a chemical that is necessary to produce occupational asthma. The need for a better appreciation of dose response, particularly relative to background, ambient levels, in the evaluation of occupational asthma is emphasized.
authors.affiliation: Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Kentucky, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Waddell
mesh_terms: D001249:Asthma / Q000139:chemically induced* / Q000175:diagnosis*; D005557:Formaldehyde / Q000009:adverse effects / Q000633:toxicity; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects / Q000633:toxicity; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D017953:Isocyanates; D005557:Formaldehyde