Experimental common cold increases mucosal output of eotaxin in atopic individuals.
BACKGROUND
In view of recent observations demonstrating that rhinovirus infections are associated with increased local activity of eosinophils, we hypothesized that eotaxin, a selective eosinophil chemoattractant, may be involved in eosinophil recruitment/activation in common cold infections.


METHODS
Twenty-three patients with seasonal allergic rhinitis were inoculated with human rhinovirus 16 (HRV 16) outside the pollen season. Sequential diluent and allergen (10(3) SQ-U) challenges, each followed by nasal lavage, were carried out about 3 months before and 4 days after virus inoculation.


RESULTS
Seventeen patients developed common cold and were further analyzed. Lavage fluid levels of eotaxin were increased at the height of active common cold (day 4 after inoculation) both at baseline (after diluent challenge) (P<0.01) and acutely after allergen challenge (P<0.05).


CONCLUSIONS
Common cold symptoms after nasal HRV 16 inoculation are associated with increased nasal mucosal output of eotaxin, suggesting that this chemokine is partly responsible for recruitment/activation of airway mucosal eosinophils in common cold infections.
Greiff
L
L
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, Lund, Sweden.
Andersson
M
M
Andersson
E
E
Linden
M
M
Myint
S
S
Svensson
C
C
Persson
C G
CG
D001798:Blood Proteins / Q000378:metabolism; D054413:Chemokine CCL11; D019742:Chemokines, CC; D003139:Common Cold / Q000378:metabolism*; D016207:Cytokines / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000502:physiology; D006801:Humans; D009297:Nasal Mucosa / Q000378:metabolism*; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism*; D012260:Ribonucleases
D001798:Blood Proteins; C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases