[Hypophyseal surgical treatment of Cushing's disease in the child].
Cushing's disease in children is rare and not familar to pediatricians. We report here 7 cases concerning children between 8 and 16 years of age, treated by pituitary surgery with 1 to 9 year follow-up. A remission of hypercorticism was obtained in all cases. However, a pituitary deficiency requiring replacement opotherapy and/or a recurrence was observed in 5 out of 7 patients. From our experience and the review of literature (around 130 cases), Cushing's disease is more serious in children than in adult. We suggest therapeutic management with transsphenoidal surgery as the treatment of choice. Given the frequency of recurrence (13 à 54%) often late (9-12 years), we stress the need of regular and extended postoperative follow-up.
Popelier
M
M
Médecine B, CHRU Tours, Hôpital Bretonneau, 2, boulevard Tonnelé, 37044 Tours Cedex.
Trouillas
J
J
Despert
F
F
Jan
M
M
Rolland
J
J
De Kernadet
M
M
Lasfargues
G
G
Lecomte
P
P
D000293:Adolescent; D002648:Child; D003480:Cushing Syndrome / Q000188:drug therapy / Q000601:surgery*; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D010902:Pituitary Gland / Q000601:surgery*; D012008:Recurrence