Flow cytometric detection of CD10 (cALLA) on peripheral blood B lymphocytes of neonates.
CD10 (cALLA) was detected on the surface of CD19-positive circulating lymphocytes in the peripheral blood of 32/50 neonates tested. These cells are presumed to represent immature B cells, commonly referred to as haematogones, previously undescribed in peripheral blood. The CD10+/CD19+ cells expressed lower levels of CD22 consistent with these cells being immature B lymphocytes. The presence of CD10+/CD19+ cells in the blood was not significantly correlated with a leucoerythroblastic picture, adjusted gestational age, or the presence in blood smears of medium-to-large lymphocytes with an immature appearance that morphologically resembled classic bone-marrow haematogones.
Brady
K A
KA
Department of Laboratory Medicine, University of California-San Francisco, San Francisco, California, USA.
Atwater
S K
SK
Lowell
C A
CA
D015703:Antigens, CD / Q000378:metabolism; D018941:Antigens, CD19 / Q000378:metabolism*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism; D001402:B-Lymphocytes / Q000378:metabolism*; D015815:Cell Adhesion Molecules; D005434:Flow Cytometry; D006801:Humans; D007231:Infant, Newborn; D037102:Lectins; D015260:Neprilysin / Q000378:metabolism*; D051918:Sialic Acid Binding Ig-like Lectin 2
D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte; C497867:CD22 protein, human; D015815:Cell Adhesion Molecules; D037102:Lectins; D051918:Sialic Acid Binding Ig-like Lectin 2; D015260:Neprilysin