title: Familial microscopic hematuria caused by hypercalciuria and hyperuricosuria.
abstract: We report 12 patients belonging to five different families in whom persistent isolated microhematuria was associated with hypercalciuria and/or hyperuricosuria. Four patients had episodes of gross hematuria, three patients had passed renal stones, and a history of nephrolithiasis was obtained in four of the families (80%). Calcium oxalate and uric acid crystals were commonly observed in the urine sediments. Urinary erythrocytes had a normal appearance on phase-microscopic examination. Reduction of calciuria and uricosuria by thiazide diuretics, allopurinol, forced fluid intake, and dietetic measures led to a persistent normalization of urine sediment with complete disappearance of hematuria. Determination of calcium and uric acid urinary excretions should be included in the study of familial hematuria.
authors.affiliation: Department of Nephrology, Hospital Universitario 12 de Octubre, Madrid, Spain. mpragat@senefro.org
authors.forename: M
authors.initials: M
authors.lastname: Praga
authors.forename: R
authors.initials: R
authors.lastname: Alegre
authors.forename: E
authors.initials: E
authors.lastname: Hernández
authors.forename: E
authors.initials: E
authors.lastname: Morales
authors.forename: B
authors.initials: B
authors.lastname: Domínguez-Gil
authors.forename: A
authors.initials: A
authors.lastname: Carreño
authors.forename: A
authors.initials: A
authors.lastname: Andrés
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000652:urine*; D002648:Child; D005260:Female; D006417:Hematuria / Q000175:diagnosis / Q000235:genetics* / Q000652:urine; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D014527:Uric Acid / Q000652:urine*
chemical_list: D014527:Uric Acid; D002118:Calcium