Intra-striatal haloperidol and scopolamine injections: effects on choice reaction time performance in rats.
In this study the behavioral consequences of intra-striatal haloperidol and scopolamine injections were examined using a reaction time task. Haloperidol was found to increase the response time of the rats and had a modest effect on the motor components of the task. The manner in which haloperidol affected the response time distribution suggested that this drug affected attentional functions. Scopolamine did not affect the reaction time or motor performance in the reaction time task. However, a clear decrease in the number of completed trials and an increase in anticipatory responses was observed. At present no ready explanation could be given for the behavioral effects of scopolamine. The present data suggest that although dopamine and acetylcholine are intimately related in the striatal network and have been supposed to have antagonistic functions, the behavioral consequences of blockade of dopamine and acetylcholine receptors are dissimilar.
Blokland
A
A
Faculty of Psychology, Section of Biological Psychology, Maastricht, The Netherlands. a.blokland@psychology.unimaas.nl
Honig
W
W
D000818:Animals; D001288:Attention / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology*
D018492:Dopamine Antagonists; D018727:Muscarinic Antagonists; D012601:Scopolamine; D006220:Haloperidol