Structure-activity study of estrogenic agonists bearing dicarba-closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules.
Dicarba-closo-dodecaboranes (carboranes), which have spherical geometry and hydrophobicity, are applicable as a hydrophobic pharmacophore of biologically active molecules. We have investigated structure-activity relations based on the structure of the potent estrogenic agonist, 1-hydroxymethyl-12-(4-hydroxyphenyl)-1,12-dicarba-closo-d odecaborane, which we have previously reported. The geometry and separation distance of the phenolic and alcoholic hydroxyl groups play a critical role in the appearance of biological activity.
Endo
Y
Y
Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan.
Iijima
T
T
Amakoshi
Y
Y
Kubo
A
A
Itai
A
A
D000818:Animals; D001896:Boron Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D019556:COS Cells; D004967:Estrogens / Q000819:agonists*; D017665:Hydroxyl Radical; D015394:Molecular Structure; D051381:Rats; D011960:Receptors, Estrogen / Q000819:agonists / Q000378:metabolism; D013329:Structure-Activity Relationship
C402710:1-hydroxymethyl-12-(4-hydroxyphenyl)-1,12-dicarbadodecaborane; D001896:Boron Compounds; D004967:Estrogens; D011960:Receptors, Estrogen; D017665:Hydroxyl Radical