title: Flow limitation and dyspnoea in healthy supine subjects during methacholine challenge.
abstract: The purpose of this study was to assess whether during standard methacholine (Mch) challenge (concentration up to 128 mg x mL(-1)) healthy supine subjects a) develop tidal expiratory flow limitation (FL) and hyperinflation, and b) whether the onset of tidal FL is associated with dyspnoea. Eight healthy subjects were studied. Dyspnoea was assessed using the Borg scale, FL by the negative expiratory pressure (NEP) method and hyperinflation in terms of decrease in inspiratory capacity (IC). Seven patients became flow limited at Mch doses ranging 4-64 mg x mL(-1), with FL encompassing 34-84% of the control tidal volume. In six of them the onset of tidal FL was associated with little or no dyspnoea and a modest degree of hyperinflation (deltaIC <-0.4 L). In one subject, however, onset of FL was associated with a substantial reduction in IC (0.58 L) and moderately severe dyspnoea. In all of these seven subjects FL was transiently reversed after an IC manoeuvre. In conclusion, the results show that a) most healthy subjects may develop flow limitation and hyperinflation during methacholine challenge in supine position, and b) at onset of flow limitation there is little or no dyspnoea, suggesting that onset of dynamic airway compression per se does not elicit significant dyspnoea. Significant dyspnoea probably only occurs with marked dynamic hyperinflation.
authors.affiliation: Meakins-Christie Laboratories and Montreal Chest Institute Research Centre, McGill University, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Sulc
authors.forename: C A
authors.initials: CA
authors.lastname: Volta
authors.forename: Y
authors.initials: Y
authors.lastname: Ploysongsang
authors.forename: L
authors.initials: L
authors.lastname: Eltayara
authors.forename: R
authors.initials: R
authors.lastname: Olivenstein
authors.forename: J
authors.initials: J
authors.lastname: Milic-Emili
mesh_terms: D000328:Adult; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology*; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents; D004417:Dyspnea / Q000175:diagnosis* / Q000503:physiopathology; D005541:Forced Expiratory Volume; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D016210:Methacholine Chloride; D010366:Peak Expiratory Flow Rate; D012016:Reference Values; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013147:Spirometry; D018709:Statistics, Nonparametric; D016683:Supine Position
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride