Large CSF volume not attributable to ventricular volume in schizotypal personality disorder.
OBJECTIVE
The purpose of this study was to determine whether schizotypal personality disorder, which has the same genetic diathesis as schizophrenia, manifests abnormalities in whole-brain and CSF volumes.


METHODS
Sixteen right-handed and neuroleptic-naive men with schizotypal personality disorder were recruited from the community and were age-matched to 14 healthy comparison subjects. Magnetic resonance images were obtained from the subjects and automatically parcellated into CSF, gray matter, and white matter. Subsequent manual editing separated cortical from noncortical gray matter. Lateral ventricles and temporal horns were also delineated.


RESULTS
The men with schizotypal personality disorder had larger CSF volumes than the comparison subjects; the difference was not attributable to larger lateral ventricles. The cortical gray matter was somewhat smaller in the men with schizotypal personality disorder, but the difference was not statistically significant.


CONCLUSIONS
Consistent with many studies of schizophrenia, this examination of schizotypal personality disorder indicated abnormalities in brain CSF volumes.
Dickey
C C
CC
Department of Psychiatry, Harvard Medical School at Brockton/West Roxbury VA Medical Center and Massachusetts Mental Health Center, Boston 02401, USA.
Shenton
M E
ME
Hirayasu
Y
Y
Fischer
I
I
Voglmaier
M M
MM
Niznikiewicz
M A
MA
Seidman
L J
LJ
Fraone
S
S
McCarley
R W
RW
D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D002552:Cerebral Ventricles / Q000033:anatomy & histology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012559:Schizophrenia / Q000175:diagnosis; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000235:genetics