Establishment of a persistent mutant of canine distemper virus.
We produced a B95a lymphoid cell line persistently infected with canine distemper virus (CDV), in which virus-specific antigens were present in nearly 100% of cells without causing cytopathic effect. The virus recovered from this cell line was able to infect fresh B95a cells persistently, indicating that a persistent CDV was established.
Iwatsuki
K
K
Department of Veterinary Microbiology, Graduate School of Agricultural and Science, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Ikeda
Y
Y
Ohashi
K
K
Nakamura
K
K
Kai
C
C
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000821:virology*; D002460:Cell Line; D004216:Distemper / Q000821:virology; D004217:Distemper Virus, Canine / Q000235:genetics* / Q000254:growth & development*; D004285:Dogs; D006389:Hemagglutinins, Viral / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D014760:Viral Fusion Proteins / Q000737:chemistry / Q000235:genetics; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
D006389:Hemagglutinins, Viral; D014760:Viral Fusion Proteins; D014764:Viral Proteins