title: Semen quality among Danish and Finnish men attempting to conceive. The Danish First Pregnancy Planner Study Team.
abstract: OBJECTIVE
  To assess differences in semen quality between similar populations from Denmark and Finland.
  
  
  METHODS
  Comparison of semen quality between 221 Finnish men (of whom 115 had no proven fertility) and 411 Danish men with no proven fertility in two follow-up studies among normal couples trying to conceive.
  
  
  METHODS
  In Finland male partners of couples without experienced infertility attempting to conceive were recruited through advertisements in local newspapers from 1984 to 1986. From 1992 to 1995 Danish men who lived with a partner and who had not attempted to achieve a pregnancy previously were recruited through their union when they discontinued birth control. All semen analyses were performed in accordance with the World Health Organization guidelines.
  
  
  RESULTS
  Median sperm concentration, total sperm count and the percentage of morphologically normal spermatozoa were significantly higher among the Finnish men without proven fertility (104.0 million/ml, 304.0 million and 58% respectively) compared with the Danish men (53.0 million/ml, 140.8 million, and 41% respectively). Sperm concentration was 105.7% (95% confidence interval (CI) 58.1%-167.6%) and total sperm count was 127.4% (95% CI 71.4%-201.6%) higher among Finnish men without proven fertility than among Danish men after control for confounders.
  
  
  CONCLUSIONS
  Some, but hardly all, of the observed difference in semen quality may be explained by differences in recruitment procedures, selection of the men and by methodological differences in semen analysis between the two countries. Also a birth cohort effect may explain some of the differences between countries as the Finnish men were recruited 11 years before the Danish men. Therefore, follow-up studies with identical recruitment and selection of men from the two countries are needed.
authors.affiliation: Department of Growth and Reproduction, Rigshospitalet, Copenhagen and Institute of Community Health, Department of Environmental Medicine, Odense University, Denmark. t.koldjensen@ic.ac.uk
authors.forename: T K
authors.initials: TK
authors.lastname: Jensen
authors.forename: M
authors.initials: M
authors.lastname: Vierula
authors.forename: N H
authors.initials: NH
authors.lastname: Hjollund
authors.forename: M
authors.initials: M
authors.lastname: Saaranen
authors.forename: T
authors.initials: T
authors.lastname: Scheike
authors.forename: S
authors.initials: S
authors.lastname: Saarikoski
authors.forename: J
authors.initials: J
authors.lastname: Suominen
authors.forename: A
authors.initials: A
authors.lastname: Keiski
authors.forename: J
authors.initials: J
authors.lastname: Toppari
authors.forename: N E
authors.initials: NE
authors.lastname: Skakkebaek
mesh_terms: D000328:Adult; D003718:Denmark; D005387:Finland; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012661:Semen / Q000502:physiology*; D013076:Sperm Count