[Effect of vitamin D3, arginine, and a biologically active complex from Serratula coronata on free radical oxidation of lipids in vitamin D deficiency].
Lipid free-radical oxidation (LFRO) on the D-deficient model with the animal administration per os by vitamin D3 (cholecalciferol), specimen from Serratula coronata plant, containing low molecular weight biological sterol--20-hydroxyecdysone (ecdysterone) was investigated. As well influence of arginine as one of the amino acid components of the specimen from Serratula coronata was investigated. The LFRO in the blood serum, liver microsomal and mitochondrial fractions were characterize by measured of the chemiluminescence kinetic parameters. Vitamin D3, the specimen from Serratula coronata plant and arginine displayed some antioxidant (AO) properties as was established. On the basis of the received experimental data the series of their antioxidizing activity: vitamin D3 = drug from Serratula coronata > arginine were offered. The possible mechanism of the 20-hydroxyecdysone and arginine participation on LFRO maybe in free-radical reactions breaking via hydroxy and amino groups in structure of their molecules.
Kuz'menko
A Y
AY
A.V. Palladin Institute Biochemistry of NAS Ukraine, Kyiv.
Morozova
R P
RP
Nykolenko
Y A
YA
Kornyets
H V
HV
Donchenko
H V
HV
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D004441:Ecdysterone / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008163:Luminescent Measurements; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D010944:Plants / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014807:Vitamin D / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism*
D005609:Free Radicals; D014807:Vitamin D; D004441:Ecdysterone; D001120:Arginine