title: Clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary antrum.
abstract: OBJECTIVE
  To further clarify the clinical significance of neck node metastasis in squamous cell carcinoma of the maxillary sinus (maxillary SCC).
  
  
  METHODS
  The medical charts of the 116 patients with maxillary SCC were retrospectively reviewed. Twelve patients (10.3%) presented initially with neck node metastases, and 14 (13.5%) of 104 node-negative patients subsequently developed regional recurrence during the follow-up period. The high-risk factors for neck node metastasis, patterns of regional failure, and survival for node-positive patients were analyzed with the patient cohort that had largely been treated with radiation alone.
  
  
  RESULTS
  Of the various factors, the tumor extension to the nasopharynx or oral cavity was the statistically significant determinants predictive of neck node metastasis at the initial diagnosis. During the follow-up period, regional failure was far less common than local failure (19.0% v 68.1%), and the majority of regional failures were accompanied by local recurrences. The oral cavity extension and control status of local disease were the high-risk factors for subsequent development of regional recurrence in node-negative patients. The overall 5-year survival rate for node-positive patients (16.7%) showed a poorer outcome compared with that for node-negative patients (31.3%), but it was similar to that of T4N0 patients (26.6%). Although patients who subsequently developed neck node recurrence during follow-up represented a dismal prognosis, uncontrolled local diseases in these patients still remained a major problem, resulting in a poor prognosis.
  
  
  CONCLUSIONS
  Despite an unfavorable prognosis of patients with neck node metastasis, an aggressive trial to achieve maximum local control of the primary tumor was considered to be more important than elective neck treatments.
authors.affiliation: Department of Radiation Oncology, Yonsei University, College of Medicine, Yonsei Cancer Center, Seoul, Korea.
authors.forename: G E
authors.initials: GE
authors.lastname: Kim
authors.forename: E J
authors.initials: EJ
authors.lastname: Chung
authors.forename: J J
authors.initials: JJ
authors.lastname: Lim
authors.forename: K C
authors.initials: KC
authors.lastname: Keum
authors.forename: S W
authors.initials: SW
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Cho
authors.forename: C G
authors.initials: CG
authors.lastname: Lee
authors.forename: E C
authors.initials: EC
authors.lastname: Choi
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary; D011379:Prognosis; D012189:Retrospective Studies