The gene for human transcription factor TCF11 is located telomeric to D17S1827, BTR and HP1Hsbeta on chromosome 17q22.
We report the screening of thirty-one YACs with a number of markers using polymerase chain reaction (PCR) to construct a physical map of part of human chromosome 17q21.3-q22. A contig of YACs covering about 4 Mb was constructed around the TCF11 gene at 68 cM from the most telomeric marker on the p arm, localizing TCF11 telomeric to genetic marker D17S1827. Both human and mouse P1-derived artificial chromosomes (PACs) containing TCF11 were isolated and characterized. The human heterochromatin protein 1 gene, HP1Hsbeta, and its homologue in mouse, MoMOD1, were identified centromeric to TCF11.
Skammelsrud
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N
Biotechnology Centre of Oslo, University of Oslo, Norway.
Martin
E R
ER
Murphy
P
P
Khuu
C
C
Frengen
E
E
Kolstø
A B
AB
D000818:Animals; D018244:Chromosomes, Artificial, Yeast; D002886:Chromosomes, Human, Pair 17; D020451:Contig Mapping; D005091:Exons; D006801:Humans; D016350:Leucine Zippers; D051379:Mice; D008969:Molecular Sequence Data; D051265:NF-E2-Related Factor 1; D020161:Physical Chromosome Mapping; D015183:Restriction Mapping; D016415:Sequence Alignment; D016615:Telomere; D014157:Transcription Factors / Q000235:genetics*
D051265:NF-E2-Related Factor 1; C088357:NFE2L1 protein, human; D014157:Transcription Factors