DNA cleavage activities of (-)-epigallocatechin, (-)-epicatechin, (+)-catechin, and (-)-epigallocatechin gallate with various kinds of metal ions.
The DNA cleavage activities of (+)-catechin (C), (-)-epicatechin (EC), (-)-epigallocatechin (EGC), and (-)-epigallocatechin gallate (EGCg) were examined with 16 different metal ions. Cu(2+) with all the catechins facilitated DNA cleavage, while Ag+ with EGC and EC showed a strong repressive effect. The other metal ions examined showed little effect.
Hayakawa
F
F
Department of Life Style Studies, School of Human Cultures, The University of Shiga Prefecture, Japan.
Kimura
T
T
Hoshino
N
N
Ando
T
T
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002417:Cattle; D003300:Copper / Q000494:pharmacology; D004247:DNA / Q000187:drug effects* / Q000378:metabolism*; D004249:DNA Damage; D005419:Flavonoids / Q000494:pharmacology; D066298:In Vitro Techniques; D008670:Metals / Q000494:pharmacology; D016877:Oxidants / Q000494:pharmacology; D012834:Silver / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000975:Antioxidants; D005419:Flavonoids; D008670:Metals; D016877:Oxidants; D012834:Silver; D003300:Copper; D002392:Catechin; D004247:DNA; C045651:epigallocatechin gallate; C057580:gallocatechol