Predominance of the T14484C mutation in French-Canadian families with Leber hereditary optic neuropathy is due to a founder effect.
Macmillan
C
C
Johns
T A
TA
Fu
K
K
Shoubridge
E A
EA
D002170:Canada / Q000453:epidemiology; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D005260:Female; D018703:Founder Effect; D005602:France / Q000208:ethnology; D006801:Humans; D008297:Male; D015418:Optic Atrophies, Hereditary / Q000208:ethnology* / Q000235:genetics; D010375:Pedigree; D017354:Point Mutation
D004272:DNA, Mitochondrial