title: Cardiac cause of hypoxaemia in a kyphoscoliotic patient.
abstract: This report presents the case of a 73 yr-old female in whom kyphoscoliosis, osteoporotic vertebra compression fractures and sternal injury resulted in severe respiratory failure and hypoxaemia. Pulmonary function testing showed moderate restrictive pattern and rare mismatches were found on lung ventilation/perfusion scanning. Transoesophageal echocardiography with contrast studies showed abnormal anatomic mediastinal interactions which led to right-to-left interatrial shunt, through patent foremen ovale. First-intention treatment, because of orthopaedic and respiratory surgical restraints, was to close the shunt using transcatheter devices. Follow-up after 6 months demonstrated that these interauricular umbrella devices corrected arterial hypoxaemia. True right-to-left interatrial shunts can be found in kyphoscoliotic patients, as a result of thoracic deformation, and can be safely treated with percutaneous trancatheter closure.
authors.affiliation: Service de Médecine Interne, Hôpital Cochin, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Herry
authors.forename: B
authors.initials: B
authors.lastname: Iung
authors.forename: J Y
authors.initials: JY
authors.lastname: Piechaud
authors.forename: F
authors.initials: F
authors.lastname: Saidi
authors.forename: C
authors.initials: C
authors.lastname: Mayaud
authors.forename: A
authors.initials: A
authors.lastname: Boissonnas
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization / Q000379:methods*; D017548:Echocardiography, Transesophageal; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000150:complications / Q000175:diagnosis; D006344:Heart Septal Defects, Atrial / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy*; D006801:Humans; D000860:Hypoxia / Q000209:etiology* / Q000628:therapy*; D015663:Osteoporosis, Postmenopausal / Q000150:complications / Q000175:diagnosis; D012129:Respiratory Function Tests; D012600:Scoliosis / Q000150:complications* / Q000175:diagnosis; D013249:Sternum / Q000293:injuries; D016896:Treatment Outcome