title: Effects of endolymphatic-perilymphatic fistula on endolymphatic hydrops in guinea pig.
abstract: The endolymphatic-perilymphatic shunt operation between the scala media and scala tympani was performed in 22 guinea pigs with endolymphatic hydrops induced by the silver nitrate injection method 2 months before the operation. Two (n = 10), 7 (n = 6), and 28 (n = 6) days after the operation, the condition of the fistula and the inner ear pathology were studied histopathologically. In half of the animals, the fistula was open, whereas in the other half, the fistula was closed. In the group examined after 2 postoperative days, the animals with open fistulas showed a slight collapse of Reissner's membrane, which might indicate that excess endolymph escaped through the fistula into the scala tympani. In the groups examined later, especially in the group examined after 28 postoperative days, the animals showed distention of hydrops despite preservation of the fistula. Moderate-to-severe degenerative changes of the organ of Corti, macula sacculi, and stria vascularis were observed in the vicinity of the fistula. We conclude from this study that the endolymphatic-perilymphatic fistula created inside the cochlea apparently was not sufficient to reduce the hydrops. Rather, it caused degenerative changes of the inner ear structure. This type of surgery is not suitable for Meniere's disease.
authors.affiliation: Department of Otolaryngology, Shiga University of Medical Science, Otsu, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yazawa
authors.forename: H
authors.initials: H
authors.lastname: Kitano
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kitanishi
authors.forename: K
authors.initials: K
authors.lastname: Kitajima
mesh_terms: D000818:Animals; D003051:Cochlea / Q000473:pathology; D003053:Cochlear Duct / Q000601:surgery*; D018159:Endolymphatic Hydrops / Q000473:pathology / Q000601:surgery*; D005402:Fistula; D006168:Guinea Pigs; D011183:Postoperative Complications; D012533:Scala Tympani / Q000601:surgery*