Lobular carcinoma of the breast metastatic to the oral cavity mimicking polymorphous low-grade adenocarcinoma of the minor salivary glands.
The oral cavity is a rare site of metastatic lesions; however, metastatic breast carcinoma must be included in the differential diagnosis of tumors of that site in women. We describe a 54-year-old woman who presented with a lesion of the floor of the mouth that histologically resembled polymorphous low-grade adenocarcinoma of the minor salivary glands, which was eventually established to represent metastatic lobular breast carcinoma. The final diagnosis was based on comparison with a primary tumor resected 13 years earlier and immunohistochemical reactivity with antibodies to steroid receptors. Relevant aspects of lobular breast carcinoma, polymorphous low-grade adenocarcinoma, and metastatic oral cavity lesions are discussed.
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Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1072, USA.
Iskandar
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SS
D000230:Adenocarcinoma / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000556:secondary* / Q000601:surgery; D012470:Salivary Glands, Minor / Q000473:pathology*
D018396:Mucin-1; D011960:Receptors, Estrogen