Nuclear matrix protein levels in burn patients with multiple organ dysfunction syndrome.
In this study, we investigated multiple organ dysfunction syndrome (MODS) and nuclear matrix protein (NMP), which is an indicator for apoptosis, in burn patients. The subjects were 17 patients with a total burn surface area (TBSA) of 26% or more. Eight of them had MODS, and nine did not. Seven patients died, and 10 survived. The NMP value in the group with MODS (610 +/- 318 units/ml) was significantly higher than in the group without MODS (82 +/- 31 units/ml). The NMP values of the patients who died (645 +/- 326 units/ml) were significantly higher than in the group who survived (111 +/- 95 units/ml), and they rose significantly as the number of impaired organs increased. Our findings suggested that the NMP level in burn cases associated with MODS was higher when apoptosis developed and larger numbers of organs were impaired.
Yamada
Y
Y
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Endo
S
S
Nakae
H
H
Kamei
Y
Y
Taniguchi
S
S
Ishikura
H
H
Tanaka
T
T
Taki
K
K
Inada
K
K
D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear; D017209:Apoptosis; D015415:Biomarkers / Q000097:blood; D002059:Burns, Inhalation / Q000097:blood* / Q000150:complications / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology / Q000401:mortality; D009569:Nitric Oxide / Q000097:blood; D009687:Nuclear Proteins / Q000097:blood*; D011379:Prognosis; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D034961:Antigens, Nuclear; D015415:Biomarkers; D009687:Nuclear Proteins; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide