title: Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
abstract: Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. Alpha-(4-nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 microg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
authors.forename: J
authors.initials: J
authors.lastname: Ishida
authors.forename: H K
authors.initials: HK
authors.lastname: Wang
authors.forename: K F
authors.initials: KF
authors.lastname: Bastow
authors.forename: C Q
authors.initials: CQ
authors.lastname: Hu
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006247:Harmine / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002243:Carbolines; D006247:Harmine