Severe factor V deficiency and neonatal intracranial haemorrhage: a case report.
We report a case of severe factor V (FV) deficiency (<1%) associated with multiple episodes of intracranial bleeding which presented at birth. The clinical course was further complicated by the development of an inhibitor, episodes of sepsis and cardiac failure. The management using virally inactivated FFP and platelets is discussed.
Salooja
N
N
Great Ormond Street Hospital for children, London, UK.
Martin
P
P
Khair
K
K
Liesner
R
R
Hann
I
I
D001424:Bacterial Infections; D001780:Blood Coagulation Tests; D016913:Blood Component Transfusion / Q000009:adverse effects; D002658:Developmental Disabilities; D004232:Diuretics / Q000627:therapeutic use; D005165:Factor V / Q000008:administration & dosage / Q000276:immunology; D005166:Factor V Deficiency / Q000150:complications* / Q000628:therapy; D005192:Family Health; D006333:Heart Failure / Q000139:chemically induced; D006408:Hematoma, Subdural / Q000209:etiology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000628:therapy; D007108:Immune Tolerance; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology* / Q000628:therapy; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000628:therapy; D007518:Isoantibodies / Q000097:blood; D008297:Male; D010154:Pakistan / Q000208:ethnology; D011654:Pulmonary Edema / Q000139:chemically induced; D006113:United Kingdom
D004232:Diuretics; D007518:Isoantibodies; D005165:Factor V