title: NAADP: An emerging calcium signaling molecule.
abstract: Cells possess multiple Ca(2+) stores and multiple messengers for mobilizing them. In addition to inositol trisphosphate and cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate (NAADP), a metabolite of NADP, is shown to be a potent Ca(2+) signaling molecule in both invertebrate and mammalian cells. This article summarizes the recent results of this newly discovered Ca(2+) signaling mechanism and explores the implications of the apparent proliferation of Ca(2+) messengers.
authors.affiliation: Department of Pharmacology, 6-120 Jackson Hall, 321 Church St. SE, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology*; D007448:Invertebrates; D008322:Mammals; D009249:NADP / Q000031:analogs & derivatives* / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009249:NADP; C024376:NAADP; D002118:Calcium