title: Antinociceptive and anti-inflammatory activity of carumbelloside-I isolated from Caralluma umbellata.
abstract: The phytochemical study using Caralluma umbellata (Asclepiadaceae) whole plant allowed the isolation of a novel pregnane glycoside named carumbelloside-I (3-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl-3beta,14beta -dihydroxypregn-5-en-20-one). Carumbelloside-I was evaluated for both antinociceptive activity and anti-inflammatory activity. The antinociceptive activity was evaluated in mice using the writhing test method, while the anti-inflammatory activity was evaluated in rats using the paw edema test with carrageenin. Carumbelloside-I has significant antinociceptive action. It has no anti-inflammatory activity.
authors.affiliation: University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India. mullangir@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Ramesh
authors.forename: Y N
authors.initials: YN
authors.lastname: Rao
authors.forename: M R
authors.initials: MR
authors.lastname: Kumar
authors.forename: A V
authors.initials: AV
authors.lastname: Rao
authors.forename: M C
authors.initials: MC
authors.lastname: Prabhakar
authors.forename: B M
authors.initials: BM
authors.lastname: Reddy
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000517:prevention & control*; D005260:Female; D005528:Foot / Q000502:physiology; D007194:India; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D011278:Pregnanes; D051381:Rats; D017208:Rats, Wistar; D012503:Saponins / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D011278:Pregnanes; D012503:Saponins; C404408:carumbelloside I; D002351:Carrageenan