title: Impact of microgravity on radiobiological processes and efficiency of DNA repair.
abstract: To study the influence of microgravity on radiobiological processes in space, space experiments have been performed, using an on-board 1xg reference centrifuge as in-flight control. The trajectory of individual heavy ions was localized in relation to the biological systems by use of the Biostack concept, or an additional high dose of radiation was applied either before the mission or during the mission from an on-board radiation source. In embryonic systems, such as early developmental stages of Drosophila melanogaster and Carausius morosus, the occurrence of chromosomal translocations and larval malformations was dramatically increased in response to microgravity and radiation. It has been hypothesized that these synergistic effects might be caused by an interference of microgravity with DNA repair processes. However, recent studies on bacteria, yeast cells and human fibroblasts suggest that a disturbance of cellular repair processes in the microgravity environment might not be a complete explanation for the reported synergism of radiation and microgravity. As an alternative explanation, an impact of microgravity on signal transduction, on the metabolic/physiological state or on the chromatin structure at the cellular level, or modification of self-assembly, intercellular communication, cell migration, pattern formation or differentiation at the tissue and organ level should be considered.
authors.affiliation: Radiation Biology Division, Institute of Aerospace Medicine, DLR German Aerospace Center, Linder Hohe, 51170, Cologne, Germany. gerda.horneck@dlr.de
authors.forename: G
authors.initials: G
authors.lastname: Horneck
mesh_terms: D000818:Animals; D001412:Bacillus subtilis / Q000235:genetics / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000196:embryology / Q000254:growth & development / Q000528:radiation effects; D004625:Embryo, Nonmammalian / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics / Q000528:radiation effects; D005118:Extraterrestrial Environment; D005347:Fibroblasts / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D018472:Hypogravity; D007477:Ions; D007814:Larva / Q000528:radiation effects; D009024:Morphogenesis / Q000528:radiation effects; D016296:Mutagenesis; D009987:Orthoptera / Q000196:embryology / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000209:etiology; D011836:Radiation Tolerance; D011853:Radiobiology; D051381:Rats; D012062:Relative Biological Effectiveness; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000528:radiation effects
chemical_list: D007477:Ions; D004247:DNA