Nasal lymphomas in Japan: a high prevalence of Epstein-Barr virus type A and deletion within the latent membrane protein gene.
The majority of nasal lymphomas are of the natural killer (NK)/T cell lineage. We analyzed 33 specimens of nasal lymphoma from Japanese patients for Epstein-Barr virus (EBV). Phenotypic and genetic analyses showed 28 cases with NK/T cell type and 5 cases with B cell type. All NK/T lymphomas were of pleomorphic cell type except 2 large cell (centroblastoid) and one lymphoblastic lymphoma. All cases with nasal B cell lymphoma were of large (centroblastoid) cell type. EBV was detected in all cases of NK/T cell type with the exception of one lymphoblastic case, and was monoclonally integrated in all cases examined (14/14 cases). All but one case had subtype A of EBV infection with 30-base paired deleted LMP-1 gene. One case of B cell lymphoma showed the presence of EBV infection with subtype A and deletion of LMP-1. Our results indicate that the majority of nasal lymphomas in Japanese patients are of the nasal NK/T cell type, have pleomorphic morphology, a high prevalence of EBV with a monoclonal integration, subtype A and deleted LMP-1 gene. In contrast, nasal B cell lymphoma showed monomorphic appearance and rare EBV infection.
Suzumiya
J
J
First Department of Pathology, School of Medicine, Fukuoka University, Japan. junsuzu@fukuoka-u.ac.jp
Ohshima
K
K
Takeshita
M
M
Kanda
M
M
Kawasaki
C
C
Kimura
N
N
Tamura
K
K
Kikuchi
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D019002:CD56 Antigen / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D005260:Female; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000145:classification / Q000235:genetics / Q000472:pathogenicity*; D006801:Humans; D016130:Immunophenotyping; D007564:Japan / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009669:Nose Neoplasms / Q000453:epidemiology / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D017384:Sequence Deletion; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology; D014763:Viral Matrix Proteins / Q000032:analysis / Q000235:genetics*; D015678:Viral Structural Proteins / Q000235:genetics
D019002:CD56 Antigen; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D009363:Neoplasm Proteins; D014763:Viral Matrix Proteins; D015678:Viral Structural Proteins