Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistant KB sublines with various resistance mechanisms. Alpha-(4-nitrobenzylidine) harmine (16) had a broad cytotoxicity spectrum (ED50 values from 0.3-1.2 microg/mL against 1A9, KB, SaOS-2, A549, SK-MEL-2, U-87-MG, and MCF-7 cells).
Ishida
J
J
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
Wang
H K
HK
Bastow
K F
KF
Hu
C Q
CQ
Lee
K H
KH
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006247:Harmine / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002243:Carbolines; D006247:Harmine