title: Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling.
abstract: Reactive oxygen species (ROS) and nitric oxide (NO) are important participants in signal transduction that could provide the cellular basis for activity-dependent regulation of neuronal excitability. In young rat cortical brain slices and undifferentiated PC12 cells, paired application of depolarization/agonist stimulation and oxidation induces long-lasting potentiation of subsequent Ca(2+) signaling that is reversed by hypoxia. This potentiation critically depends on NO production and involves cellular ROS utilization. The ability to develop the Ca(2+) signal potentiation is regulated by the developmental stage of nerve tissue, decreasing markedly in adult rat cortical neurons and differentiated PC12 cells.
authors.affiliation: Department of Physiology, University of Iowa, Bowen Science Building, Iowa City, IA 52242, USA.
authors.forename: O
authors.initials: O
authors.lastname: Yermolaieva
authors.forename: N
authors.initials: N
authors.lastname: Brot
authors.forename: H
authors.initials: H
authors.lastname: Weissbach
authors.forename: S H
authors.initials: SH
authors.lastname: Heinemann
authors.forename: T
authors.initials: T
authors.lastname: Hoshi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects*; D002454:Cell Differentiation; D016257:Fura-2 / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism; D051150:Methionine Sulfoxide Reductases; D020932:Nerve Growth Factor / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009599:Nitroprusside / Q000494:pharmacology; D010088:Oxidoreductases / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D016716:PC12 Cells; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D017382:Reactive Oxygen Species; D009599:Nitroprusside; D009569:Nitric Oxide; D006632:Histamine; D020932:Nerve Growth Factor; D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D051150:Methionine Sulfoxide Reductases; C027219:methionine sulfoxide reductase; D011188:Potassium; D010100:Oxygen; D016257:Fura-2