Role of adhesion molecules in chronic allograft rejection.
Endothelial adhesion molecules play an important role in T cell recruitment to an allograft site. Therefore, it could be expected that their blocking may be beneficial for allograft survival. In this report, we show that T cells from patients with chronic rejection have an up-regulated ability to adhere to inflamed endothelium in vitro. Furthermore, this enhanced T cell: endothelial interaction could be blocked by anti-VCAM and anti-E-selectin monoclonal antibodies.
Nowaczyk
M
M
Department of Clinical Immunology, University Medical School, Warsaw, Poland.
Górski
A
A
Durlik
M
M
Wyzgał
J
J
Perkowska-Francka
A
A
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002460:Cell Line; D002908:Chronic Disease; D019040:E-Selectin / Q000502:physiology; D004730:Endothelium, Vascular / Q000276:immunology; D006084:Graft Rejection / Q000209:etiology* / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology; D016030:Kidney Transplantation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D019010:Vascular Cell Adhesion Molecule-1 / Q000502:physiology
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1