title: Anti-allergic components from the peels of Citrus unshiu.
abstract: In a bioassay-guided search for anti-allergic compounds from higher plants of Korea, polymethoxyflavones, 3',4',5,6,7,8-hexamethoxyflavone (1), 5-hydroxy-3',4',6,7,8-pentamethoxyflavone (II) and 3',4',5,7,8,-pentamethoxyflavone (III) have been isolated from the immature peels of Citrus unshiu. Structures of these compounds were elucidated on the basis of spectroscopic techniques. Compounds I and II inhibited dose-dependently histamine release from the rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE.
authors.affiliation: College of Pharmacy, Woosuk University, Samrye, Korea. dkkim@core.woosuk.ac.kr
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: K T
authors.initials: KT
authors.lastname: Lee
authors.forename: J S
authors.initials: JS
authors.lastname: Eun
authors.forename: O P
authors.initials: OP
authors.lastname: Zee
authors.forename: J P
authors.initials: JP
authors.lastname: Lim
authors.forename: S S
authors.initials: SS
authors.lastname: Eum
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: T Y
authors.initials: TY
authors.lastname: Shin
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D007723:Korea; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D018926:Anti-Allergic Agents; D010936:Plant Extracts