title: Anti-inflammatory cytokine response and clinical outcome in acute pancreatitis.
abstract: OBJECTIVE
  To test the hypothesis that elevated interleukin (IL)-10 plasma concentration relative to IL-6 and IL-8 in patients with acute pancreatitis is associated with improved clinical outcome.
  
  
  METHODS
  Case series.
  
  
  METHODS
  University hospital surgical and intensive care unit.
  
  
  METHODS
  Patients with mild (n = 18) and severe (n = 14) acute pancreatitis were recruited within 12 hrs of admission and studied for 5 days.
  
  
  METHODS
  None.
  
  
  RESULTS
  The plasma concentration of IL-10 was significantly elevated in patients with severe pancreatitis during the 5 days and especially so in those who died compared with survivors on day 5 (p <.03). The ratio of IL-10/IL-6 was decreased in patients with severe pancreatitis on day 5 (p < .01). There was a significant decrease in the ratio of IL-10/IL-8, but not of IL-10/IL-6, during the first 5 days (p < .014).
  
  
  CONCLUSIONS
  The findings are consistent with the hypothesis that an increase in plasma IL-10 relative to IL-6 or IL-8 is associated with improved clinical outcome.
authors.affiliation: Pancreatitis Research Group, Department of Surgery, Faculty of Medicine and Health Science, University of Auckland, New Zealand.
authors.forename: M O
authors.initials: MO
authors.lastname: Simovic
authors.forename: M J
authors.initials: MJ
authors.lastname: Bonham
authors.forename: F M
authors.initials: FM
authors.lastname: Abu-Zidan
authors.forename: J A
authors.initials: JA
authors.lastname: Windsor
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood; D010195:Pancreatitis / Q000145:classification / Q000276:immunology* / Q000401:mortality / Q000628:therapy; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015850:Interleukin-6; D016209:Interleukin-8; D016753:Interleukin-10