title: A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy-(10alpha-2H)paclitaxel.
abstract: 10-Deacetoxy-(10alpha-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, Lawrence 66045, USA.
authors.forename: D
authors.initials: D
authors.lastname: Dutta
authors.forename: H
authors.initials: H
authors.lastname: Hadd
authors.forename: D G
authors.initials: DG
authors.lastname: Vander Velde
authors.forename: G I
authors.initials: GI
authors.lastname: Georg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry; D003903:Deuterium; D009682:Magnetic Resonance Spectroscopy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D043823:Taxoids / Q000031:analogs & derivatives
chemical_list: C402708:10-deacetoxypaclitaxel; D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D003903:Deuterium; D017239:Paclitaxel