title: The effect of six weeks topical nasal betamethasone drops on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis.
abstract: Betamethasone topical nasal drops may have systemic corticosteroid activity and cause suppression of the hypothalamo-pituitary-adrenal (HPA) axis and impairment of bone turnover. The aim of this study was to assess the effect of a standard 6-week regime of betamethasone topical nasal drops on the HPA axis (using a physiological dose (1 microg) ACTH test) and on bone turnover (using markers of bone turnover, urinary deoxypyridinoline and serum bone specific alkaline phosphatase). Eleven patients with nasal polyposis were included in a prospective cohort study. Plasma cortisol was lower after betamethasone treatment at all time intervals (P < 0. 0001). There was no change in urinary deoxypyridinoline corrected for creatinine or bone specific alkaline phosphatase. Six weeks' treatment with recommended doses of betamethasone suppresses the HPA axis, but has no significant effect upon markers of bone turnover. Topical betamethasone in subjects with nasal polyps should be viewed as systemic corticosteroid administration and the long and short-term sequelae should be borne in mind.
authors.affiliation: Department of Diabetes, University Hospital, Nottingham, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Gazis
authors.forename: J J
authors.initials: JJ
authors.lastname: Homer
authors.forename: D B
authors.initials: DB
authors.lastname: Henson
authors.forename: S R
authors.initials: SR
authors.lastname: Page
authors.forename: N S
authors.initials: NS
authors.lastname: Jones
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001623:Betamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D015415:Biomarkers / Q000032:analysis; D016723:Bone Remodeling / Q000187:drug effects*; D001842:Bone and Bones / Q000378:metabolism; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D009298:Nasal Polyps / Q000188:drug therapy*; D010913:Pituitary-Adrenal System / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D015415:Biomarkers; C036020:deoxypyridinoline; D001623:Betamethasone; D000469:Alkaline Phosphatase; D006854:Hydrocortisone