title: Four new members expand the interleukin-1 superfamily.
abstract: We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.
authors.affiliation: Immunex Corp., Seattle, Washington 98101, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Smith
authors.forename: B R
authors.initials: BR
authors.lastname: Renshaw
authors.forename: R R
authors.initials: RR
authors.lastname: Ketchem
authors.forename: M
authors.initials: M
authors.lastname: Kubin
authors.forename: K E
authors.initials: KE
authors.lastname: Garka
authors.forename: J E
authors.initials: JE
authors.lastname: Sims
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D017124:Conserved Sequence; D005091:Exons; D005260:Female; D015698:Genomic Library; D006801:Humans; D007375:Interleukin-1 / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D007438:Introns; D008297:Male; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017433:Protein Structure, Secondary; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured
chemical_list: D007375:Interleukin-1; D020033:Protein Isoforms; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins