Immuno-, phagocytosis-modulating and antitoxic properties of dipeptides are defined by the activity of their constituent amino acids.
In experiments on mice and the influence in vitro of the dipeptides GluTrp, LysAsp, LysVal, AspGlu, GluAsp on their constituent amino acids and mixtures on the indexes of specific and non-specific resistance was studied. There is no difference between the dipeptides and their constituent amino acids (excepting Lys) neither in immune, phagocytosis modulating or antitoxic properties. Some amino acids (aspartic acid, glutamic acid, methionine and tryptophan) are promising for the effective prevention of diseases that develop as a result of chronic benzene intoxication.
Belokrylov
G A
GA
The Institute for Experimental Medicine, St Petersburg State University, Russia.
Popova OYa
Sorochinskaya
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EI
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D000931:Antidotes / Q000737:chemistry* / Q000494:pharmacology; D001224:Aspartic Acid / Q000494:pharmacology; D001554:Benzene / Q000633:toxicity; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects; D007107:Immune System / Q000187:drug effects*; D008297:Male; D008715:Methionine / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects*; D011817:Rabbits; D013601:T-Lymphocytes / Q000187:drug effects; D014364:Tryptophan / Q000494:pharmacology
D000596:Amino Acids; D000931:Antidotes; D004151:Dipeptides; C403564:lysyl aspartic acid; C021030:gamma-glutamylaspartic acid; D001224:Aspartic Acid; C057081:alpha-glutamyltryptophan; D018698:Glutamic Acid; C038676:aspartylglutamate; D014364:Tryptophan; D008715:Methionine; D001554:Benzene; C110469:lysylvaline