title: Cade's observation of the antimanic effect of lithium and early Australian research.
abstract: John Cade had a major influence on the treatment of affective disorders following his report in 1949. His discovery of the efficacy of lithium as an antimanic agent was the result of an inevitable progression from the hypothesis of a metabolic basis for mania to clinical trials. Starting with animal studies, he progressed to patients. Further reports on lithium in the Medical Journal of Australia quickly followed in 1950 and 1951. The present paper reports on these and other Australian studies over the next few years. Lithium has moved in 50 years from a novel status to an internationally recognised major treatment of affective disorders.
authors.affiliation: University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia. gdb@austin.unimelb.edu.au
authors.forename: G D
authors.initials: GD
authors.lastname: Burrows
authors.forename: J W
authors.initials: JW
authors.lastname: Tiller
mesh_terms: D018692:Antimanic Agents / Q000266:history* / Q000494:pharmacology / Q000627:therapeutic use; D001315:Australia; D001714:Bipolar Disorder / Q000188:drug therapy / Q000266:history* / Q000503:physiopathology; D049673:History, 20th Century; D006801:Humans; D016651:Lithium Carbonate / Q000266:history* / Q000494:pharmacology / Q000627:therapeutic use; D010506:Periodicals as Topic / Q000266:history; D011570:Psychiatry / Q000266:history; D012106:Research / Q000266:history
chemical_list: D018692:Antimanic Agents; D016651:Lithium Carbonate