[Glyciram as an enhancer of the effectiveness of chemotherapy and surgery in the treatment of experimental neoplasms].
Glycyrramum was shown to potentiate the antitumor and antimetastatic effects of cyclophosphamide treatment in mice and rats with transplantable tumors. It also decreased its myelotoxicity. After primary Lewis lung carcinoma was removed glycyrramum treatment significantly inhibited metastacizing processes in mice.
Razina
T G
TG
Research Institute of Pharmacology, Siberian Branch of Russian Academy of Medical Sciences, Tomsk.
Zueva
E P
EP
Amosova
E N
EN
Zhdanov
V V
VV
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000517:prevention & control / Q000556:secondary / Q000601:surgery; D003520:Cyclophosphamide / Q000494:pharmacology; D004357:Drug Synergism; D005260:Female; D006034:Glycyrrhetinic Acid / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D003520:Cyclophosphamide; D006034:Glycyrrhetinic Acid