title: Bioactive indole alkaloids from the bark of Uncaria guianensis.
abstract: Bioassay-guided fractionation of the EtOH extract of the bark of Uncaria guianensis (Aubl.) Gmel (Rubiaceae) using a yeast-based assay for DNA-damaging agents has furnished the two weakly but selectively active indole alkaloids uncarine C (1) and uncarine E (2) as the major bioactive constituents in this assay.
authors.forename: K K
authors.initials: KK
authors.lastname: Lee
authors.forename: B N
authors.initials: BN
authors.lastname: Zhou
authors.forename: D G
authors.initials: DG
authors.lastname: Kingston
authors.forename: A J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: G B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D016475:3T3 Cells; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D019666:Rubiaceae / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D007211:Indoles