Antimicrobial activity of substituted azoles and their nucleosides.
Four new 2'-deoxynucleosides of benzimidazole derivatives were prepared. Antimicrobial activity of many indazole, benzotriazole, benzimidazole derivatives and their nucleosides were tested by the agar diffusion method. Among the investigated compounds, dinitro- and trifluoromethyl-substituted benzimidazoles and their nucleosides were the most potent.
Stefańska
J Z
JZ
Department of Pharmaceutical Microbiology, Medical University of Warsaw, Poland.
Gralewska
R
R
Starościak
B J
BJ
Kazimierczuk
Z
Z
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D001393:Azoles; D009705:Nucleosides