A comparison of enalapril 20 mg once daily versus 10 mg twice daily in terms of blood pressure lowering and patient compliance.
OBJECTIVE
To compare enalapril 20 mg once daily with 10 mg twice daily in terms of blood pressure reduction and patient compliance.


METHODS
Cross-over study of patients randomly assigned to a sequence of enalapril 20 mg once daily or 10 mg twice daily in three 4-week periods following a 4-week placebo run-in.


METHODS
General practices in the greater Belfast and Lisburn area in Northern Ireland.


METHODS
Twenty-five hypertensive patients who had a mean diastolic blood pressure of between 90 and 110 mm Hg after receiving placebo for 4 weeks.


METHODS
Reduction in blood pressure and estimation of patient compliance.


RESULTS
Patient compliance was superior on the once daily regimen. However, the twice daily regimen was associated with a greater blood pressure reduction which almost reached statistical significance at the 5% level.


CONCLUSIONS
Enalapril 20 mg should be prescribed as 10 mg twice daily and measures taken to improve patient compliance.
Girvin
B
B
Department of Therapeutics and Pharmacology, The Queen's University of Belfast, UK.
McDermott
B J
BJ
Johnston
G D
GD
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D018592:Cross-Over Studies; D004334:Drug Administration Schedule; D004656:Enalapril / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D010349:Patient Compliance; D011187:Posture / Q000502:physiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril