title: Cellular radiosensitivity of patients with papillary thyroid cancer.
abstract: Cultured skin fibroblasts from patients with papillary (differentiated) thyroid carcinomas were compared to those from healthy subjects, ataxia telangiectasia (AT) homozygotes and AT heterozygotes for colony-forming ability after low dose-rate irradiation, and post-irradiation DNA synthesis as indicated by uptake of [3H]-thymidine. The cells from the cancer patients exhibited enhanced radiosensitivity (intermediate between normal and AT) and less than normal level of radioinduced inhibition of DNA synthesis.
authors.affiliation: Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: Ahmed
authors.forename: F
authors.initials: F
authors.lastname: Al-Khodairy
authors.forename: B A
authors.initials: BA
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Kunhi
authors.forename: M A
authors.initials: MA
authors.lastname: Hannan
mesh_terms: D000328:Adult; D000368:Aged; D001260:Ataxia Telangiectasia / Q000235:genetics; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000532:radiotherapy*; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects*; D005720:Gamma Rays; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011836:Radiation Tolerance; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000532:radiotherapy*
chemical_list: D004247:DNA