Transcriptional control in myelinating glia: the basic recipe.
Development of myelinating glia and the myelination process both require dramatic changes in the pattern of gene expression. During these processes, cells of the oligodendrocyte and Schwann cell lineages have to alter the transcription rates of numerous genes in a highly coordinated manner. This is made possible by the combined action of a set of transcription factors with preferential expression in these cells. Recent years have seen the identification of such glial transcription factors, including several homeodomain proteins, zinc finger proteins and HMG-domain proteins. Understanding their mode of action will help to unravel the molecular basis of myelination and will provide insights into the causes of myelinopathies and related diseases.
Wegner
M
M
Zentrum für Molekulare Neurobiologie, Universität Hamburg, Hamburg, Germany.
D000818:Animals; D005786:Gene Expression Regulation; D006609:High Mobility Group Proteins / Q000502:physiology; D018398:Homeodomain Proteins / Q000502:physiology; D006801:Humans; D051379:Mice; D009186:Myelin Sheath / Q000235:genetics* / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis / Q000502:physiology; D016335:Zinc Fingers / Q000502:physiology
D006609:High Mobility Group Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors