[Free radical processes in combined chronic inhalation effect of xenobiotics on the rat].
The chronic combined inhalation influence of nitric oxides (II, IV), amorphic hydrophobic silicon dioxide, lead and radon on the free radical processes intensively was investigated. The dienic conjugates, lipid hydroperoxides and MDA concentration in the liver and kidney of the white mongrel male-rats was defined. It has been shown that lipid peroxidation process displaies sensitivity toward complex exposure of the most wide-spreader xenobiotics. It was expressed in the content decreasing of there products at the first step of our experience as a result of the action of the adaptive and compensative mechanisms directed to the suppression of the peroxidation processes. As a result of the antioxidant system powers exhaustion it was found the content rising of the lipid peroxidation products at the last step of our experience. It has been proposed to use the total content index of the lipid peroxidation products as a criteria of the organism resistant ion toward action of the exogenic factors of various origin.
Hirin
S V
SV
Ukrainian Research Institute of Industrial Medicine, Kryvyi Rig.
D000818:Animals; D005609:Free Radicals; D019570:Inhalation Exposure; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000008:administration & dosage / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000008:administration & dosage / Q000494:pharmacology; D011886:Radon / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D012822:Silicon Dioxide / Q000008:administration & dosage / Q000494:pharmacology; D015262:Xenobiotics / Q000008:administration & dosage / Q000494:pharmacology*
D005609:Free Radicals; D008054:Lipid Peroxides; D015262:Xenobiotics; D007854:Lead; D009569:Nitric Oxide; D008315:Malondialdehyde; D012822:Silicon Dioxide; D011886:Radon