title: Serendipitous rapid detoxification from opiates: the importance of time-dependent processes.
abstract: Opiate detoxification procedures aim to reduce intensity and duration of withdrawal. Ultra-rapid opiate detoxification (UROD) methods attempt to obtain this goal by administering naltrexone under deep sedation or anaesthesia. We present a case study on accidental ingestion of naltrexone in a methadone maintenance patient, which shows close methodological similarities with UROD procedures. Naltrexone was effective in reducing withdrawal duration, but not as much as UROD studies report. The administration of naloxone after detoxification did not trigger withdrawal symptoms, even in the presence of methadone, as detected by urinalyses. These results suggest the importance of further developing detoxification methods based on protocols of administration of antagonists different from UROD, in absence of anaesthesia.
authors.affiliation: Servizio Farmacodipendenze, Università Cattolica S. Cuore, Rome, Italy. mannelli@itaca.com
authors.forename: P
authors.initials: P
authors.lastname: Mannelli
authors.forename: S
authors.initials: S
authors.lastname: De Risio
authors.forename: G
authors.initials: G
authors.lastname: Pozzi
authors.forename: L
authors.initials: L
authors.lastname: Janiri
authors.forename: M
authors.initials: M
authors.lastname: De Giacomo
mesh_terms: D000328:Adult; D006556:Heroin Dependence / Q000534:rehabilitation; D006801:Humans; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D009271:Naltrexone / Q000008:administration & dosage / Q000009:adverse effects*; D009292:Narcotic Antagonists / Q000009:adverse effects*; D009294:Narcotics / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D009292:Narcotic Antagonists; D009294:Narcotics; D009271:Naltrexone; D008691:Methadone