Inhibition of colonisation of the alimentary tract in young chickens with Campylobacter jejuni by pre-colonisation with strains of C. jejuni.
Strains of Campylobacter jejuni, isolated from human gastro-intestinal infection and inoculated orally into 1-day-old chicks, colonised the alimentary tract (caecum) well. There was evidence of invasion from the intestine to the spleen. Oral inoculation with some but not all strains of C. jejuni 24 h earlier (within 12 h of hatching) prevented establishment by challenge strains administered orally 1 day later. One strain which was less able to colonise the gut was less inhibitory than other strains. Precolonisation of newly hatched chicks with a strain of Salmonella typhimurium had no inhibitory effect on establishment by the challenge strain of C. jejuni and may even have exacerbated it. Inhibition of multiplication of a nalidixic acid-resistant mutant of a C. jejuni strain was prevented when it was added to a stationary-phase broth culture of the antibiotic-sensitive parent strain and the mixed culture re-incubated.
Barrow
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PA
Division of Environmental Microbiology, Institute for Animal Health, Compton Laboratory, Compton, Newbury, UK. paul.barrow@bbsrc.ac.uk
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D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002169:Campylobacter Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary; D016123:Campylobacter jejuni / Q000187:drug effects / Q000235:genetics / Q000254:growth & development*; D002432:Cecum / Q000382:microbiology*; D002645:Chickens / Q000382:microbiology*; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D009268:Nalidixic Acid / Q000494:pharmacology; D011201:Poultry Diseases / Q000517:prevention & control; D012486:Salmonella typhimurium / Q000254:growth & development / Q000472:pathogenicity; D013154:Spleen / Q000382:microbiology
D000890:Anti-Infective Agents; D009268:Nalidixic Acid