title: The "missing link" in the origin of trigeminal neuralgia: a new theory and case report.
abstract: Tic Douloureux (Trigeminal Neuralgia) has afflicted mankind for centuries, perhaps for all time. This sharp stabbing paroxysm of pain along the branches of the trigeminal nerve is described as "...one of the most painful problems that plagues mankind." Many theories about the cause of trigeminal neuralgia have been previously presented. Often these theories build on the previous foundations when new research presents itself. The complete picture still eludes researchers today. Much of the mechanism has been proposed, but researchers lacked one essential component. There has never been an answer to why these pains only occur in cranial segments and why, thankfully, TN is rare. What sets the stage for the development of TN? The unique neurophysiology of the trigeminal nerve and the accompanying ability of the Temporomandibular Joints to create a sensitized neural system are the last piece of the puzzle. This central sensitization of the Trigeminal Nerve allows the development of a small cluster of neurons that act as a central trigger for the paroxysmal pain. The role of the TMJ in trigeminal neuralgia is illustrated by this case report.
authors.forename: D B
authors.initials: DB
authors.lastname: Miller
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000368:Aged; D003769:Dental Occlusion, Traumatic / Q000150:complications* / Q000209:etiology; D003832:Denture, Partial, Removable / Q000009:adverse effects*; D005157:Facial Pain / Q000209:etiology / Q000473:pathology; D005246:Feedback; D005260:Female; D006801:Humans; D008335:Mandibular Condyle / Q000473:pathology; D009619:Nociceptors; D013704:Temporomandibular Joint / Q000294:innervation / Q000503:physiopathology*; D014277:Trigeminal Neuralgia / Q000209:etiology* / Q000503:physiopathology*