Reduction of tyrosine kinase B and tyrosine kinase C inductions by treatment with neurotrophin-3 after transient middle cerebral artery occlusion in rat.
Infarct volume and immunoreactivities for trkB and trkC in rat brain were compared at 24 h after 90 min of transient middle cerebral artery occlusion (MCAO) between animal groups with or without neurotrophin-3 (NT-3, 10 microg/250 g animal). Treatment of rat brain with topical application of NT-3 significantly reduced infarct volume (P = 0.02) and trkB and trkC inductions. These data suggest that NT-3 reduced the ischemic injury along with the reduction of trkB and trkC inductions.
Zhang
W R
WR
Department of Neurology, Okayama University Medical School, Japan.
Hayashi
T
T
Wang
J M
JM
Sasaki
C
C
Sakai
K
K
Warita
H
H
Shiro
Y
Y
Suenaga
H
H
Ohmae
H
H
Tsuji
S
S
Itoh
T
T
Nishimura
O
O
Nagasaki
H
H
Abe
K
K
D000287:Administration, Topical; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000201:enzymology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002536:Cerebral Arteries; D002544:Cerebral Infarction / Q000473:pathology; D004790:Enzyme Induction / Q000187:drug effects; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D020933:Neurotrophin 3 / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D020813:Receptor, trkB / Q000037:antagonists & inhibitors; D020812:Receptor, trkC / Q000037:antagonists & inhibitors
D007527:Isoenzymes; D020933:Neurotrophin 3; D011505:Protein-Tyrosine Kinases; D020813:Receptor, trkB; D020812:Receptor, trkC