[Multiple phlebothrombosis following cesarean section due to heterozygous factor V Leiden mutation detected post partum].
Activated protein C resistance in factor V Leiden mutation is currently the most frequent hereditary defect accompanied by high risk of thromboembolism. Thromboembolism often develops in the presence of additional risk factors such as pregnancy, birth, taking oral contraceptives, immobilization and surgical operations. A case of multiple phlebothrombosis following caesarean section in heterozygous factor V Leiden mutation evidenced post partum is reported. The patient developed extensive phlebothrombosis in both legs on postoperative day three despite preventive thrombosis treatment with low-molecular heparin. She also suffered from short-term incomplete paresis of her left arm and epileptic seizure with typical grand mal symptoms. MRI showed partial thrombosis of the superior sagittal sinus and the transverse sinus.
Grulich
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D
Klinik für Gynäkologie und Geburtshilfe des Carl-Thiem-Klinikum Cottbus.
Schulze
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Riedel
H H
HH
D020016:Activated Protein C Resistance / Q000150:complications* / Q000235:genetics; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002585:Cesarean Section / Q000009:adverse effects*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017354:Point Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis*; D011256:Pregnancy Outcome; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D016896:Treatment Outcome
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V