title: Is there a relationship between serum S-100beta protein and neuropsychologic dysfunction after cardiopulmonary bypass?
abstract: OBJECTIVE
  Over the past decade, the glial protein S-100beta has been used to detect cerebral injury in a number of clinical settings including cardiac surgery. Previous investigations suggest that S-100beta is capable of identifying patients with cerebral dysfunction after cardiopulmonary bypass. Whether detection of elevated levels S-100beta reflects long-term cognitive impairment remains to be shown. The present study evaluated whether perioperative release of S-100beta after coronary artery operations with cardiopulmonary bypass could predict early or late neuropsychologic impairment.
  
  
  METHODS
  A total of 100 patients undergoing elective coronary bypass without a previous history of neurologic events were prospectively studied. To exclude noncerebral sources of S-100beta, we did not use cardiotomy suction or retransfusion of shed mediastinal blood. Serial perioperative measurements of S-100beta were performed with the use of a new sensitive immunoluminometric assay up to 8 hours after the operation. Patients underwent cognitive testing on a battery of 11 tests before the operation, before discharge from the hospital, and 3 months later.
  
  
  RESULTS
  No significant correlation was found between S-100beta release and neuropsychologic measures either 5 days or 3 months after the operation.
  
  
  CONCLUSIONS
  Despite using a sensitive immunoluminometric assay of S-100beta, we found no evidence to support the suggestion that early release of S-100beta may reflect long-term neurologic injury capable of producing cognitive impairment.
authors.affiliation: Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: S
authors.initials: S
authors.lastname: Westaby
authors.forename: K
authors.initials: K
authors.lastname: Saatvedt
authors.forename: S
authors.initials: S
authors.lastname: White
authors.forename: T
authors.initials: T
authors.lastname: Katsumata
authors.forename: W
authors.initials: W
authors.lastname: van Oeveren
authors.forename: N K
authors.initials: NK
authors.lastname: Bhatnagar
authors.forename: S
authors.initials: S
authors.lastname: Brown
authors.forename: P W
authors.initials: PW
authors.lastname: Halligan
mesh_terms: D000768:Anesthesia, General; D001007:Anxiety / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D003866:Depressive Disorder / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D009418:S100 Proteins / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D009418:S100 Proteins