title: Inherited thrombophilia genes in minorities.
abstract: Mutations in several genes have recently been identified which predispose to thrombosis, specifically Factor V G1691A (Factor V Leiden), Prothrombin G20210A, and Methylene tetrahydrofolate reductase (MTHFR) C677T. The prevalence of these genes in European populations has been studied, but there is little data on their prevalence in minorities. Samples from a predominantly African-American population were analyzed for these mutations. While the G20210A mutation in the prothrombin gene and homozygosity for the C677T mutation of the MTHFR were not found in African-Americans, it appears that the carrier rate for the MTHFR C677T among Hispanics may be higher than in other reported groups.
authors.affiliation: Department of Pathology and Laboratory Medicine, New Jersey Medical School/UMDNJ, Newark 07103, USA.
authors.forename: R
authors.initials: R
authors.lastname: Mack
authors.forename: D
authors.initials: D
authors.lastname: Chowdary
authors.forename: D
authors.initials: D
authors.lastname: Streck
authors.forename: J
authors.initials: J
authors.lastname: Dermody
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005165:Factor V / Q000235:genetics; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D019851:Thrombophilia / Q000235:genetics*; D014481:United States; D044465:White People / Q000235:genetics*; D001741:Black or African American
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)