title: Decrease in the prevalence of hepatitis B and a low prevalence of hepatitis C virus infections in the general population of the Seychelles.
abstract: A serological survey of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections was carried out on a random sex- and age-stratified sample of 1006 individuals aged 25-64 years in the Seychelles islands. Anti-HBc and anti-HCV antibodies were detected using commercially available enzyme-linked immunosorbent assays (ELISA), followed by a Western blot assay in the case of a positive result for anti-HCV. The age-adjusted seroprevalence of anti-HBc antibodies was 8.0% (95% CI: 6.5-9.9%) and the percentage prevalence among males/females increased from 7.0/3.1 to 19.1/13.4 in the age groups 25-34 to 55-64 years, respectively. Two men and three women were positive for anti-HCV antibodies, with an age-adjusted seroprevalence of 0.34% (95% CI: 0.1-0.8%). Two out of these five subjects who were positive for anti-HCV also had anti-HBc antibodies. The seroprevalence of anti-HBc was significantly higher in unskilled workers, persons with low education, and heavy drinkers. The age-specific seroprevalence of anti-HBc in this population-based survey, which was conducted in 1994, was approximately three times lower than in a previous patient-based survey carried out in 1979. Although there are methodological differences between the two surveys, it is likely that the substantial decrease in anti-HBc prevalence during the last 15 years may be due to significant socioeconomic development and the systematic screening of blood donors since 1981. Because hepatitis C virus infections are serious and the cost of treatment is high, the fact that the prevalence of anti-HCV antibodies is at present low should not be an argument for not screening blood donors for anti-HCV and eliminating those who are positive.
authors.affiliation: University Institute for Social and Preventive Medicine, Lausanne, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Bovet
authors.forename: C
authors.initials: C
authors.lastname: Yersin
authors.forename: P
authors.initials: P
authors.lastname: Herminie
authors.forename: D
authors.initials: D
authors.lastname: Lavanchy
authors.forename: P C
authors.initials: PC
authors.lastname: Frei
mesh_terms: D000328:Adult; D017677:Age Distribution; D000437:Alcoholism / Q000150:complications; D019353:Endemic Diseases / Q000706:statistics & numerical data*; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000097:blood; D006526:Hepatitis C / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D011159:Population Surveillance; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D017678:Sex Distribution; D012750:Seychelles / Q000453:epidemiology; D012959:Socioeconomic Factors
chemical_list: D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies