Administration time-dependent effect of nitrendipine on the reduction of cardiac hypertrophy in spontaneously hypertensive rats.
The influence of administration time of nitrendipine on the regression of cardiac mass was studied in spontaneously hypertensive rats (SHR). Nitrendipine (100 mg/kg) was given once daily at 10 AM or 10 PM for 16 weeks. Similar reductions of the trough blood pressure were observed in both groups. Cardiac biventricular mass in the animals dosed at 10 PM was significantly less than that in the vehicle-treated rats, whereas in the rats dosed at 10 AM no significant reduction was noted in the cardiac mass. These data suggest that the administration time of nitrendipine has a different effect on the regression of cardiac hypertrophy in SHR.
Shiga
T
T
Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Sugimoto
K
K
Fujimura
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage*; D006332:Cardiomegaly / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D006352:Heart Ventricles / Q000187:drug effects / Q000473:pathology; D006973:Hypertension / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage*; D009929:Organ Size; D051381:Rats; D013997:Time Factors; D016896:Treatment Outcome
D002121:Calcium Channel Blockers; D009568:Nitrendipine