title: Hippocampal asymmetries and white matter abnormalities on MRI in benign childhood epilepsy with centrotemporal spikes.
abstract: OBJECTIVE
  To look for brain abnormalities by using magnetic resonance imaging (MRI) in patients with benign childhood epilepsy with centrotemporal spikes (BCECTS), which is the most common epilepsy syndrome in children.
  
  
  METHODS
  Eighteen children, aged 6-12 years, with typical BCECTS were examined with MRI, six of them twice.
  
  
  RESULTS
  Some hippocampal abnormality was found in six (33%) of the children, all with the syndrome's typical electroencephalogram (EEG) pattern ipsilaterally. Hippocampal size asymmetry was found in five (28%) children (right side < left in two and left < right in three), and high signal intensities on T2-weighted images were found in three (17%). Two children also had other abnormalities; one had a heterotopic nodule near the contralateral frontal horn, and one had an Arnold-Chiari malformation. The hippocampal asymmetry remained unchanged in three of the children who were reexamined after 2 years. High signal intensities on T2-weighted images were seen beneath the cortex-white matter junction in the frontal and temporal lobes of five (28%) children, one of whom also had a hippocampal asymmetry. MRIs were normal in eight (44%) children.
  
  
  CONCLUSIONS
  For the first time, hippocampal asymmetries and white-matter abnormalities have been detectable on the MRIs of children with typical BCECTS. The etiology of the former is unclear, whereas the latter may be a result of a maturational delay involving a defective myelination. Long-term follow-up studies are needed to evaluate the relation between these findings and the clinical course of BCECTS.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Lundberg
authors.forename: O
authors.initials: O
authors.lastname: Eeg-Olofsson
authors.forename: R
authors.initials: R
authors.lastname: Raininko
authors.forename: K E
authors.initials: KE
authors.lastname: Eeg-Olofsson
mesh_terms: D002540:Cerebral Cortex / Q000033:anatomy & histology*; D002648:Child; D019305:Epilepsy, Rolandic / Q000175:diagnosis*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000033:anatomy & histology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male