Relation of basic and clinical research on foetal and neonatal thyroid pathology to neonatal thyroid screening.
In this short review the importance is emphasized of basic and clinical research in regard to the interpretation of screening results. This review covers foetal thyroid physiology during the first 48 h of life, the importance of thyroid hormones for normal brain development, the definition of a critical period which might explain intellectual abnormalities in 10-15% of detected hypothyroid children and the importance of autoimmunity in the aetiology and diagnosis of transient congenital hypothyroidism.
Dussault
J H
JH
Research Unit in Human Genetics, Research Center, CHUQ, Ste-Foy, Quebec, Canada. jean.h.dussault@crchul.ulaval.ca
D000818:Animals; D015551:Autoimmunity; D002170:Canada; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000503:physiopathology*; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology; D015997:Neonatal Screening; D011247:Pregnancy; D051381:Rats; D012107:Research Design; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism*
D013963:Thyroid Hormones