title: Iontophoresis for treatment of Peyronie's disease.
abstract: OBJECTIVE
  We evaluate the efficacy of iontophoresis of dexamethasone, lidocaine and verapamil to treat Peyronie's disease.
  
  
  METHODS
  In an uncontrolled prospective study 100 unselected patients with Peyronie's disease were treated with 3 weekly courses of iontophoresis. The drug mixture was administered by an electrical current of 5 mA. and a self-adhesive receptacle fixed to the penile skin overlying the plaque.
  
  
  RESULTS
  Resolution of pain was observed in 96% of patients, plaque diminution in 53% and improvement of penile deviation in 37%. Impaired sexual function was improved in 19 of 43 patients (44%). The benefit of iontophoresis therapy was more pronounced in patients with a short history of disease. Because of lack of side effects and painless administration iontophoresis was well tolerated and accepted by all patients.
  
  
  CONCLUSIONS
  Iontophoresis of dexamethasone, lidocaine and verapamil may be regarded as first line nonsurgical treatment for Peyronie's disease.
authors.affiliation: Department of Urology and Ludwig Boltzmann Institute of Andrology, Municipal Hospital Lainz, Vienna, Austria.
authors.forename: C R
authors.initials: CR
authors.lastname: Riedl
authors.forename: E
authors.initials: E
authors.lastname: Plas
authors.forename: P
authors.initials: P
authors.lastname: Engelhardt
authors.forename: K
authors.initials: K
authors.lastname: Daha
authors.forename: H
authors.initials: H
authors.lastname: Pflüger
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D006801:Humans; D007478:Iontophoresis; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010411:Penile Induration / Q000188:drug therapy*; D011446:Prospective Studies; D014700:Verapamil / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D008012:Lidocaine; D014700:Verapamil