title: Immunohistochemical estimations of growth activity to predict biological behavior of pheochromocytomas.
abstract: To determine the usefulness of immunohistochemical estimations of growth activity to predict biological behavior of pheochromocytomas (PC), 42 cases of PC (33 adrenal and nine extra-adrenal tumors) were studied by immunohistochemistry using the monoclonal antibody, MIB-1. The mean MIB-1-positive cell rate for all 42 PCs was low (1.4%). The MIB-1-positive cell rates of adrenal PCs were significantly higher in malignant tumors (mean, 3.30%) than in benign tumors (mean, 0.81%) (P = .0184). In extra-adrenal PCs, the difference between benign (mean, 0.44%) and malignant (mean, 5.10%) tumors was also statistically significant (P = .0004). Other clinicopathologic factors, including family history, age, sex, and multiple endocrine neoplasm (MEN) type II status were also examined and were not statistically significant. In conclusion, estimation of the MIB-1-positive cell rate is useful for histologic distinction between benign and malignant pheochromocytomas. Especially, it is important to note that a high MIB-1-positive cell rate (>2%) is highly suggestive of malignancy.
authors.affiliation: Department of Pathology, Yamanashi Medical University, Tamaho, Japan. sn96D09@stu.yamanashi-med.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Nagura
authors.forename: R
authors.initials: R
authors.lastname: Katoh
authors.forename: A
authors.initials: A
authors.lastname: Kawaoi
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Obara
authors.forename: K
authors.initials: K
authors.lastname: Omata
mesh_terms: D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear; D001324:Autoantigens / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism; D010673:Pheochromocytoma / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D034961:Antigens, Nuclear; D001324:Autoantigens; D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D009418:S100 Proteins; D016159:Tumor Suppressor Protein p53