[Radiobiological assessment of radiation injuries in various regimens of total body irradiation].
A radiobiological evaluation of dose-time regimens of total body irradiation (TBI) using a single-exposure multi-target (MM) and a linear-quadratic (LQM) models of cell destruction has been carried out. An equivalent of single dose of acute irradiation was used as a criterion of biological effect of LQM. The latter proved useful in analyzing all kinds of dose-time regimens of TBI including those employing different doses. Practically speaking, single exposure to 5 Gy and irradiation by three daily fractions in a total dose of 10 Gy may be recommended for wide clinical application.
Afanas'ev
B P
BP
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Kozlov
A P
AP
Akimov
A A
AA
Moskalik
K G
KG
D001853:Bone Marrow / Q000528:radiation effects; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007422:Intestines / Q000187:drug effects; D016014:Linear Models; D008168:Lung / Q000187:drug effects; D008954:Models, Biological; D011832:Radiation Injuries / Q000209:etiology*; D014916:Whole-Body Irradiation / Q000009:adverse effects* / Q000379:methods