Analysis of HLA-DRB1 alleles in Japanese patients with chronic myelogenous leukemia.
To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA-DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA-DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA-DRB1 alleles and CML.
Yasukawa
M
M
First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan. yasukawa@m.ehime-u.ac.jp
Ohminami
H
H
Kojima
K
K
Inokuchi
K
K
Nishimura
Y
Y
Fujita
S
S
D000483:Alleles; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007564:Japan; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D020133:Reverse Transcriptase Polymerase Chain Reaction
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D016044:Fusion Proteins, bcr-abl