Anti-inflammatory activity of Aglaia roxburghiana var. beddomei extract and triterpenes roxburghiadiol A and B.
The alcoholic extracts of the aerial portion and fruits of Aglaia roxburghiana (W.& A.) Miq. var. beddomei and the triterpenes roxburghiadiol A and B isolated from this plant were investigated for their anti-inflammatory activity in rats by carrageenin induced rat paw oedema and cotton pellet granuloma methods. They were also studied for their effect on mast cell degranulation induced by compound 48/80. Potent anti-inflammatory activity was observed for the extracts of the aerial portion and fruits of A. roxburghiana as well as for the triterpenes roxburghiadiol A and B. The mast cell degranulation induced by compound 48/80 was significantly reduced by A. roxburghiana extracts and the triterpenes. The triterpenes roxburghiadiol A and B may play a significant role in the observed anti-inflammatory effect of A. roxburghiana.
Janaki
S
S
Institute of Pharmacology, Chennai Medical College, India. abishaik@netscape.net
Vijayasekaran
V
V
Viswanathan
S
S
Balakrishna
K
K
D000704:Analysis of Variance; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D015550:Cell Degranulation / Q000187:drug effects; D004487:Edema; D006614:Hindlimb; D007194:India; D007928:Lethal Dose 50; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D008515:Medicine, Ayurvedic; D051379:Mice; D010840:Phytosterols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D010840:Phytosterols; D010936:Plant Extracts; C064688:roxburghiadiol A