title: Organization of the corticotectal projection in hamsters with neonatally elevated levels of serotonin in the superior colliculus.
abstract: A previous study from this laboratory showed that elevated serotonin (5-HT) levels in the hamsters superior colliculus (SC), induced by a single subcutaneous injection of 5,7-dihydroxytryptamine (5,7-DHT) at birth, resulted in an abnormally widespread distribution of the uncrossed retinotectal projection. The present study investigated whether the corticotectal projection in such animals was altered. Adult normal and 5,7-DHT-treated hamsters were injected with horseradish peroxidase (HRP) into occipital cortex and processed for anterograde tracing of corticotectal terminals in the SC. Quantitative analysis showed that normal and 5,7-DHT-treated hamsters were not significantly different in total labeling or in the gradient of labeling density within the SC. These data indicate that corticotectal axons achieve normal terminal fields after neonatal elevation of 5-HT in the SC.
authors.affiliation: Department of Anatomy and Neurobiology, Medical College of Ohio, Toledo 43614-5804, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Crnko-Hoppenjans
authors.forename: J
authors.initials: J
authors.lastname: Yaggie
authors.forename: R D
authors.initials: RD
authors.lastname: Mooney
authors.forename: R W
authors.initials: RW
authors.lastname: Rhoades
mesh_terms: D015116:5,7-Dihydroxytryptamine; D000818:Animals; D000831:Animals, Newborn; D006224:Cricetinae; D017729:Presynaptic Terminals / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D018490:Serotonin Agents; D013477:Superior Colliculi / Q000254:growth & development* / Q000378:metabolism; D014793:Visual Cortex / Q000254:growth & development* / Q000378:metabolism
chemical_list: D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin