title: Evolutionally conserved plant homologue of the Bax inhibitor-1 (BI-1) gene capable of suppressing Bax-induced cell death in yeast(1).
abstract: The plant homologue of Bax Inhibitor-1, a gene described to suppress the cell death induced by Bax gene expression in yeast, was isolated from Oryza sativa L. (rice) and Arabidopsis. The amino acid sequence of the predicted protein was well conserved in both animal and plant (45% in amino acids) and contained six or seven membrane-spanning segments. Northern blot analysis showed that OsBI-1 transcripts were present in all tissues examined. The OsBI-1 cDNA suppressed cell death induced by mammalian Bax in yeast, suggesting functional conservation of this BI-1 homologue in the plant kingdom.
authors.affiliation: Advanced Science Research Center, Japan Atomic Energy Research Institute, Takasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: L
authors.initials: L
authors.lastname: Pan
authors.forename: J C
authors.initials: JC
authors.lastname: Reed
authors.forename: H
authors.initials: H
authors.lastname: Uchimiya
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D017360:Arabidopsis / Q000235:genetics*; D029681:Arabidopsis Proteins; D001483:Base Sequence; D018076:DNA, Complementary; D019143:Evolution, Molecular; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D012275:Oryza / Q000235:genetics*; D011506:Proteins; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors* / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2; D012441:Saccharomyces cerevisiae / Q000166:cytology; D017386:Sequence Homology, Amino Acid; D051028:bcl-2-Associated X Protein
chemical_list: C491862:ATBI-1 protein, Arabidopsis; D051017:Apoptosis Regulatory Proteins; D029681:Arabidopsis Proteins; C494826:BAX protein, human; D018076:DNA, Complementary; D008565:Membrane Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; C484209:TMBIM6 protein, human; D051028:bcl-2-Associated X Protein