title: High-dose chemotherapy with hematopoietic stem cell transplantation in adults with bone marrow relapse of medulloblastoma: report of two cases.
abstract: Extraneural relapses of medulloblastoma are associated with a very poor outcome. We present two cases of young adults who developed bone marrow metastases after treatment of medulloblastoma. A very good response to a sequentially scheduled combination of carboplatin and etoposide was observed. Then, high-dose chemotherapy was delivered consisting of busulfan and thiotepa followed by infusion of autologous hematopoietic stem cells. Toxicity of the conditioning regimen was acceptable. The patients remained free of disease 20 and 27 months from the time of relapse, respectively. Further studies are needed to evaluate the impact of high-dose chemotherapy in terms of survival of such patients.
authors.affiliation: Department of Haematology and Medical Oncology, Poitiers University Hospital, France.
authors.forename: F
authors.initials: F
authors.lastname: Millot
authors.forename: O
authors.initials: O
authors.lastname: Delval
authors.forename: C
authors.initials: C
authors.lastname: Giraud
authors.forename: B
authors.initials: B
authors.lastname: Bataille
authors.forename: P
authors.initials: P
authors.lastname: Babin
authors.forename: T
authors.initials: T
authors.lastname: Germain
authors.forename: A
authors.initials: A
authors.lastname: Sadoun
authors.forename: P
authors.initials: P
authors.lastname: Vandermarq
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000556:secondary; D002528:Cerebellar Neoplasms / Q000150:complications / Q000628:therapy*; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000150:complications / Q000628:therapy*; D012008:Recurrence; D019172:Transplantation Conditioning
chemical_list: D000970:Antineoplastic Agents