title: Respiratory failure attributable to moxidectin intoxication in a dog.
abstract: A 5-month-old 22-kg (48.4-lb) sexually intact male Collie was examined after ingesting a moxidectin-containing deworming medication. The dog was comatose and had respiratory arrest after progressively worsening lethargy, ataxia, and seizures. Exposure was confirmed by isolation of moxidectin from a biopsy specimen of adipose tissue, using liquid chromatography-mass spectroscopy methods. Treatment included use of intermittent positive-pressure ventilation, activated charcoal and cathartic administered enterally, nutrients administered via nasogastric tube, and intensive supportive care. The dog was weaned from a ventilator on day 6 after ingestion and was discharged on day 10. The dog was considered clinically normal during examination 24 days after ingestion. On the basis of the dog reported here and toxicologic data provided by the manufacturer of the deworming product, some Collies may have increased susceptibility to products containing high doses of moxidectin.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Beal
authors.forename: R H
authors.initials: RH
authors.lastname: Poppenga
authors.forename: W J
authors.initials: WJ
authors.lastname: Birdsall
authors.forename: D
authors.initials: D
authors.lastname: Hughes
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000818:Animals; D000871:Anthelmintics / Q000032:analysis / Q000506:poisoning*; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000506:poisoning; D001774:Blood Chemical Analysis / Q000662:veterinary; D001784:Blood Gas Analysis / Q000662:veterinary; D003975:Diazepam / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced* / Q000628:therapy; D004285:Dogs; D004562:Electrocardiography / Q000662:veterinary; D007385:Intermittent Positive-Pressure Ventilation / Q000662:veterinary; D018942:Macrolides; D008297:Male; D009460:Neurologic Examination / Q000662:veterinary; D011015:Pneumonia, Aspiration / Q000662:veterinary; D011041:Poisoning / Q000628:therapy / Q000662:veterinary; D013902:Radiography, Thoracic / Q000662:veterinary; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary*; D012640:Seizures / Q000139:chemically induced / Q000662:veterinary
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin; D003975:Diazepam