[Comparative efficacy of combined therapy with preductal and amino acid composition in elderly patients with coronary heart disease and class II-III angina].
OBJECTIVE
A comparative analysis of effectiveness of combined therapy including trimetazidine (preductal) and composition of amino acids (glutamic acid, glycin and cystein) in elderly patients with coronary heart disease and angina of functional class II-III (FC II-III).


METHODS
60 patients (47 females and 13 males, mean age 66.4 +/- 0.5 years) with IHD, angina FC II-III, postinfarction cardiosclerosis and circulatory failure stage I-IIA were randomized into 3 randomized groups. Control patients received conventional antianginal therapy with nitrates, beta-adrenoblockers, calcium antagonists, diuretics, ACI inhibitors, cardiac glycosides and aspirin. Patients of group 1 received conventional treatment + complex of amino acids in dose 100 mg 3 times a day sublingually. Group 2 patients received adjuvant preductal for 20 days in dose 20 mg 3 times a day per os. Assessment was made clinically, with echo-CG data, bimanual isometric loading and Holter 24-h ECG monitoring.


RESULTS
All the three methods showed antianginal, hypotensive effects, brought higher tolerance to exercise and improvement of hemodynamics. The basic therapy produced the least effect.


CONCLUSIONS
Metabolic therapy with amino acids and preductal combined with conventional methods brings more pronounced antianginal and hemodynamic effects than combined therapy alone.
Zaslavskaia
R M
RM
Kelimberdieva
E S
ES
Komissarova
I A
IA
Teĭblium
M M
MM
Goncharov
L F
LF
Goncharova
Z F
ZF
Akhmetov
K Zh
KZh
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology; D003545:Cysteine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D018698:Glutamic Acid / Q000627:therapeutic use*; D005998:Glycine / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D018698:Glutamic Acid; D003545:Cysteine; D014292:Trimetazidine; D005998:Glycine