title: The effect of the width of the ventilation-perfusion distribution on arterial blood oxygen content.
abstract: We investigate the effect of the width of ventilation-perfusion distributions on arterial blood oxygen content. We assume that the perfusion within the alveolar volume is a continuous function of ventilation-perfusion ratio, known as the continuous ventilation-perfusion distribution, and then write down the conservation of mass equations in the lung incorporating the nonlinear relationship between oxygen concentration in the gas phase and blood oxygen content. We solve these equations for various unimodal and bimodal ventilation-perfusion distributions believed to occur in practice and calculate the arterial blood oxygen content in each case. When a subject has a unimodal ventilation-perfusion distribution we show that the fraction of cardiac output to that mode (i.e. the fraction of non-shunted blood) has a large effect on arterial oxygen blood content. However, the width of the distribution has only a negligible effect on arterial oxygen blood content. For a bimodal ventilation-perfusion distribution the location and fraction of cardiac output to each mode has a large effect on arterial oxygen blood content. Again, the width of each mode of the distribution has little effect on arterial oxygen blood content. As a result there is little point, from a clinical perspective, in developing techniques for investigating the width of modes of these distributions since all relevant clinical information is contained in the nature (i.e. unimodal or bimodal) and in the location of the modes.
authors.affiliation: Nuffield Department of Anaesthetics, University of Oxford, Radcliffe Infirmary, Woodstock Road, Oxford, OX2 6HE, U.K.
authors.forename: J P
authors.initials: JP
authors.lastname: Whiteley
authors.forename: D J
authors.initials: DJ
authors.lastname: Gavaghan
authors.forename: C E
authors.initials: CE
authors.lastname: Hahn
mesh_terms: D001158:Arteries; D002302:Cardiac Output; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D011650:Pulmonary Alveoli; D014692:Ventilation-Perfusion Ratio
chemical_list: D010100:Oxygen