[Intestinal infections due to inhibition of gastric acid secretion in reflux disease].
Gastric acid stimulates the absorption of nutrients and is the most important non-immunological defence system against the constant bacterial invasion of our digestive tract. Patients with achlorhydria and resected stomachs have excessive growth of bacteria in the digestive tract and a much higher incidence of gastrointestinal infections. Modern treatment of reflux oesophagitis with acid secretion inhibitors creates a similar low acid state. Suppression of gastric acid secretion causes a dose dependent increased risk of a wide variety of intestinal infections especially for people over 65, immune compromised persons, sick patients with a reduced resistance and travellers to tropical areas. The potentially dangerous infections can be reduced by adequate counselling about the importance of gastric acid, the precaution of improved hygiene, on demand use of especially proton pump inhibitors and prescription of antacids and less potent acid inhibitors.
Otten
M H
MH
Ziekenhuis Eemland, afd. Maag-, Darm- en Leverziekten, Amersfoort.
D000126:Achlorhydria / Q000139:chemically induced / Q000150:complications*; D000897:Anti-Ulcer Agents / Q000009:adverse effects*; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D005767:Gastrointestinal Diseases / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D007239:Infections / Q000382:microbiology
D000897:Anti-Ulcer Agents