title: Fetal growth and adverse birth outcomes in women receiving prescriptions for acetaminophen during pregnancy. EuroMap Study Group.
abstract: We studied the association between acetaminophen exposure during pregnancy and the prevalence of congenital abnormalities and fetal growth. Our study included 123 women who had received a prescription of acetaminophen during pregnancy and/or 30 days before conception and 13,329 controls who did not receive any prescription at all. We found more malformations among those who received a prescription with an odds ratio of 2.3 (95% CI 1.0-5.4), but the type of malformations did not indicate a causal link. When restricting the study to first time pregnancies, we identified 58 women who received a prescription of acetaminophen during pregnancy and 30 days before conception and 7472 controls. We found no excess risk of malformation [OR = 0.7 (95% CI 0.1-5.5)], and no evidence that acetaminophen should influence fetal growth.
authors.affiliation: Department of Medicine V and The Danish Epidemiology Science Centre, Aarhus University.
authors.forename: A M
authors.initials: AM
authors.lastname: Thulstrup
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
authors.forename: G L
authors.initials: GL
authors.lastname: Nielsen
authors.forename: L
authors.initials: L
authors.lastname: Andersen
authors.forename: D
authors.initials: D
authors.lastname: Barrett
authors.forename: H
authors.initials: H
authors.lastname: Vilstrup
authors.forename: J
authors.initials: J
authors.lastname: Olsen
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000082:Acetaminophen / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D016001:Confidence Intervals; D019992:Databases as Topic; D003718:Denmark; D011307:Drug Prescriptions; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D018811:Maternal Exposure; D008498:Medical Record Linkage; D008875:Middle Aged; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012042:Registries; D012307:Risk Factors
chemical_list: D000082:Acetaminophen