Modeling of drug release from swellable polymers.
The water Swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug. The transport equation for water incorporated a relaxation-dependent mechanism. These equations were solved with an appropriate boundary condition incorporating a relaxation-dependent Deborah number. Experimental results from drug release from PVA and PHEMA samples were used to determine the validity of the model.
Brazel
C S
CS
Biomaterials and Drug Delivery Laboratories, School of Chemical Engineering, Purdue University, West Lafayette, IN 47907-1283, USA.
Peppas
N A
NA
D004058:Diffusion; D008956:Models, Chemical; D011108:Polymers / Q000493:pharmacokinetics*; D013806:Theophylline / Q000493:pharmacokinetics; D014223:Triamterene / Q000493:pharmacokinetics; D014805:Vitamin B 12 / Q000493:pharmacokinetics
D011108:Polymers; D013806:Theophylline; D014805:Vitamin B 12; D014223:Triamterene