Immunohistochemical expression of BerEP4, a new epithelial antigen, in endometrial carcinoma: correlation with clinical parameters.
OBJECTIVE
To assess the immunochemical expression of BerEP4, a new epithelial antigen in endometrial carcinoma.


METHODS
We studied 45 cases of endometrial carcinoma in which the BerEP4, CEA and TAG-72 antigens were searched by an immunohistochemical method. We evaluated the correlations among the immunohistochemical positivity and the grading, histotype, stage and receptorial status of the neoplasia.


RESULTS
CEA was positive in 29 out of 45 cases (64.4%), TAG-72 in 17 out of 45 cases (37.7%) and BerEP4 in 31 out of 45 cases (68.9%). Both TAG-72 and CEA were inversely related to the grading while, with regard to the histotype, CEA resulted as highly positive in the 5 cases of adenoacanthoma.


CONCLUSIONS
BerEP4 did not show any correlation with grading, histotype, stage of disease or receptorial status of the carcinoma.
Cherchi
P L
PL
Department of Pharmacology, Gynaecology and Obstetrics, University of Sassari, Italy.
Bosincu
L
L
Dessole
S
S
Ruiu
G A
GA
Cossu Rocca
P
P
Capobianco
G
G
Tanda
F
F
Ambrosini
A
A
D000951:Antigens, Neoplasm / Q000378:metabolism; D000954:Antigens, Surface / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D009367:Neoplasm Staging
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D006023:Glycoproteins; C115012:human epithelial antigen-125; C047052:tumor-associated antigen 72