title: Occurrence of hippocampal sclerosis: is one hemisphere or gender more vulnerable?
abstract: OBJECTIVE
  We analyzed a large group of patients investigated for suspected seizures to test whether gender or side are important factors in the origins of hippocampal sclerosis (HS).
  
  
  METHODS
  We studied 996 consecutive patients (48% men, 52% women) by using standard hippocampal T2-relaxometry methods.
  
  
  RESULTS
  HS was associated with a highly abnormal T2 time (< or =113 ms). Categoric analysis showed that hippocampal T2 time was independent of gender and side. T2 time was bilaterally normal in 81% of men and in 79% of women; it was unilaterally abnormal in 15% of both men and women; and bilaterally abnormal in 4% of men and in 6% of women. Highly abnormal T2 relaxometry, suggesting HS, occurred with equal frequency in men and women and on the right and left sides. Quantitative analysis of hippocampal T2 times showed values not differing significantly between men and women or between the right and left hemispheres. There was no significant interaction between gender and side.
  
  
  CONCLUSIONS
  In patients with seizure disorders, hippocampal T2 relaxometry is not different in adult men and women and in the right and left hemispheres.
authors.affiliation: Brain Imaging Research Institute, Department of Neurology, Austin and Repatriation Medical Center, Heidelberg, Victoria, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Briellmann
authors.forename: G D
authors.initials: GD
authors.lastname: Jackson
authors.forename: L A
authors.initials: LA
authors.lastname: Mitchell
authors.forename: G J
authors.initials: GJ
authors.lastname: Fitt
authors.forename: S E
authors.initials: SE
authors.lastname: Kim
authors.forename: S F
authors.initials: SF
authors.lastname: Berkovic
mesh_terms: D000328:Adult; D015897:Comorbidity; D004827:Epilepsy / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012598:Sclerosis; D012720:Severity of Illness Index; D012737:Sex Factors