title: Predicting survival in patients with recurrent symptomatic malignant pleural effusions: an assessment of the prognostic values of physiologic, morphologic, and quality of life measures of extent of disease.
abstract: OBJECTIVE
  To determine the prognostic value of pleural fluid pH, pleural fluid glucose, extent of pleural carcinomatosis (EPC) score, and Karnofsky Performance Scale (KPS) score in patients with recurrent symptomatic malignant pleural effusions.
  
  
  METHODS
  Prospective 53-month study.
  
  
  METHODS
  Referral center for interventional pulmonology.
  
  
  METHODS
  Eighty-five consecutive patients (42 men and 43 women) with recurrent symptomatic malignant pleural effusions who were referred to the interventional pulmonary service for thoracoscopic pleurodesis.
  
  
  METHODS
  Pleural fluid pH, pleural fluid glucose, EPC score, and KPS score.
  
  
  RESULTS
  The KPS score was the only statistically significant predictor variable. Patients with a KPS score >/= 70 had a median survival of 395 days, as opposed to a median survival of only 34 days for patients with a KPS score </= 30. No prognostic advantage was evident when patients were categorized by pleural fluid pH, pleural fluid glucose, or EPC score.
  
  
  CONCLUSIONS
  When assessing the prognosis of a patient with a recurrent symptomatic malignant pleural effusion, only the KPS score at the time of thoracoscopy is predictive of survival. Pleural fluid pH, pleural fluid glucose, and EPC scores are not as reliable as initially reported. For patients with a KPS score >/= 70, it may be very reasonable to proceed with thoracoscopic talc pleurodesis for management of their malignant pleural effusions.
authors.affiliation: University of California at San Diego Medical Center, San Diego, CA, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Burrows
authors.forename: W C
authors.initials: WC
authors.lastname: Mathews
authors.forename: H G
authors.initials: HG
authors.lastname: Colt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001826:Body Fluids / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016066:Pleural Effusion, Malignant / Q000378:metabolism / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D018700:Pleurodesis; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D015996:Survival Rate; D013627:Talc / Q000008:administration & dosage; D013906:Thoracoscopy
chemical_list: D014408:Biomarkers, Tumor; D013627:Talc; D005947:Glucose