Seprafilm-induced peritoneal inflammation: a previously unknown complication. Report of a case.
BACKGROUND
Various substances and agents have been evaluated to prevent postoperative adhesion formation. Recently a sodium hyaluronate-based bioresorbable membrane was introduced with promising clinical results. Its application was regarded as safe and efficient.


METHODS
We present the first reported case of a severe inflammatory reaction to a bioresorbable membrane and give a review of the related literature.


CONCLUSIONS
Bioresorbable membranes are increasingly used by general surgeons and gynecologists to reduce postoperative adhesion formation. Bioresorbable membranes may produce extensive inflammatory reactions.
Klingler
P J
PJ
Department of General Surgery, Mayo Clinic Jacksonville, Florida 32224, USA.
Floch
N R
NR
Seelig
M H
MH
Branton
S A
SA
Wolfe
J T
JT
Metzger
P P
PP
D020341:Absorbable Implants / Q000009:adverse effects*; D000368:Aged; D001672:Biocompatible Materials / Q000009:adverse effects*; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000601:surgery; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007081:Ileostomy; D008297:Male; D008567:Membranes, Artificial; D010538:Peritonitis / Q000209:etiology*; D011183:Postoperative Complications / Q000517:prevention & control / Q000601:surgery; D012007:Rectum / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control / Q000601:surgery
D001672:Biocompatible Materials; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid