Microascus cinereus (Anamorph scopulariopsis) brain abscess in a bone marrow transplant recipient.
We report the first documented case of brain abscess due to the dematiaceous fungus Microascus cinereus, an organism common in soil and stored grain. M. cinereus was isolated from brain abscess material from a bone marrow transplant recipient. The patient responded well to treatment by amphotericin B lipid complex, itraconazole, and a craniotomy but later died from secondary complications caused by graft-versus-host disease.
Baddley
J W
JW
University of Alabama at Birmingham, Birmingham, Alabama, USA. jbaddley@uabid.dom.uab.edu
Moser
S A
SA
Sutton
D A
DA
Pappas
P G
PG
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification* / Q000648:ultrastructure; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001922:Brain Abscess / Q000175:diagnosis* / Q000188:drug therapy; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis* / Q000188:drug therapy; D003399:Craniotomy; D004338:Drug Combinations; D005260:Female; D006086:Graft vs Host Disease / Q000401:mortality; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D010713:Phosphatidylcholines / Q000627:therapeutic use; D010715:Phosphatidylglycerols / Q000627:therapeutic use
D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B