How to build a molecular shock absorber.
Newly determined structures of the alpha-helical repeats that make up the key 'rod' domains of spectrin and alpha-actinin - which serve as spacers between their actin-binding domains - have provided important insights into how these proteins function as molecular shock absorbers in cells.
McGough
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Verna & Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, TX 77030, USA. amcgough@bcm.tmc.edu
D000185:Actinin / Q000737:chemistry; D002462:Cell Membrane / Q000737:chemistry; D004912:Erythrocytes / Q000737:chemistry / Q000502:physiology; D006801:Humans; D008962:Models, Theoretical; D017433:Protein Structure, Secondary; D013049:Spectrin / Q000737:chemistry / Q000502:physiology*; D013314:Stress, Mechanical; D013329:Structure-Activity Relationship
D000185:Actinin; D013049:Spectrin