Adsorption of drugs onto a poly(acrylic acid) grafted cation-exchange membrane.
The influence of pH, ionic strength and the concentration of albumin in the adsorption medium as well as the charge and lipophilicity of a model drug on their adsorption onto poly(acrylic acid) grafted poly(vinylidene fluoride) (PAA-PVDF) membranes was evaluated. The PAA-PVDF membrane is a responsive porous polymer membrane that we have studied for controlled drug delivery. Sodium salicylate (anionic), flunitrazepam (neutral), primidone (neutral), desipramine (cationic) and thioridazine (cationic) were used as model drugs. The extent of drug adsorption was dependent on pH. Drug adsorption was enhanced by the dissociation of the grafted PAA chains and by a positive charge and a high lipophilicity of the drug. Increasing the ionic strength of the medium retarded the adsorption of the cationic drugs. Interestingly, the present results showing that drugs are adsorbed onto the membrane while albumin is not adsorbed onto the membrane suggest that the PAA-PVDF membrane may be suitable for separating drugs from proteinaceous substances for subsequent monitoring and evaluation.
Akerman
S
S
Department of Pharmaceutics, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland.
Akerman
K
K
Karppi
J
J
Koivu
P
P
Sundell
A
A
Paronen
P
P
Järvinen
K
K
D000179:Acrylates / Q000737:chemistry*; D000327:Adsorption; D000818:Animals; D002412:Cations / Q000493:pharmacokinetics*; D002417:Cattle; D003891:Desipramine / Q000493:pharmacokinetics; D005445:Flunitrazepam / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D009994:Osmolar Concentration; D011108:Polymers / Q000737:chemistry*; D011324:Primidone / Q000493:pharmacokinetics; D012709:Serum Albumin / Q000737:chemistry; D012980:Sodium Salicylate / Q000493:pharmacokinetics; D012995:Solubility; D013881:Thioridazine / Q000493:pharmacokinetics; D014753:Vinyl Compounds / Q000737:chemistry
D000179:Acrylates; D002412:Cations; D008567:Membranes, Artificial; D011108:Polymers; D012709:Serum Albumin; D014753:Vinyl Compounds; D011324:Primidone; C007384:1,1-difluoroethylene; D005445:Flunitrazepam; C036658:acrylic acid; D013881:Thioridazine; D003891:Desipramine; D012980:Sodium Salicylate