title: Isotretinoin therapy for antibiotic-refractory acne in Apert's syndrome.
abstract: Apert's syndrome is a congenital disorder characterized by the premature fusion of the cranial sutures and early epiphyseal closure. Severe pustular acne is a common feature. We report a case that failed to respond to conventional antibiotic treatment but resolved following isotretinoin therapy. The patient's permanent tracheostomy proved a management challenge during isotretinoin treatment. The role of androgen-sensitivity is discussed in relation to the skin and bones.
authors.affiliation: Department of Dermatology, Bristol Royal Infirmary, Bristol, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Downs
authors.forename: C A
authors.initials: CA
authors.lastname: Condon
authors.forename: R
authors.initials: R
authors.lastname: Tan
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000168:Acrocephalosyndactylia / Q000150:complications* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents; D015474:Isotretinoin; D010118:Oxytetracycline