title: [Hepatotoxicity caused by therapeutic doses of paracetamol in alcoholics. Report of 2 cases of fatal hepatitis in cirrhosis].
abstract: Paracetamol is a widely used medication as it is an effective analgesic and antipyretic. Because of the absence of gastro-intestinal side effects, it has been used as the analgesic of choice for alcoholic patients. Hepatotoxicity is dose-related and generally occurs in patients who absorb more than 125 mg/kg/j. However, cases of severe liver damage have been reported after absorption of therapeutic doses of paracetamol in alcoholics. We report 2 cases with a fatal outcome and discuss the mechanisms of toxicity, the prognostic factors and treatment of such event.
authors.affiliation: Service de Réanimation, Centre Hospitalier Laennec, Creil.
authors.forename: A
authors.initials: A
authors.lastname: Mofredj
authors.forename: J F
authors.initials: JF
authors.lastname: Cadranel
authors.forename: B
authors.initials: B
authors.lastname: Darchy
authors.forename: J C
authors.initials: JC
authors.lastname: Barbare
authors.forename: A
authors.initials: A
authors.lastname: Cazier
authors.forename: V
authors.initials: V
authors.lastname: Pras
authors.forename: M
authors.initials: M
authors.lastname: Biour
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen