title: The need for using fluoroscopic guidance to obtain gastric biopsies when in search of Helicobacter pylori with a nonendoscopic method.
abstract: OBJECTIVE
  Nonendoscopic, fluoroscopic biopsy of the gastric mucosa, following barium examination of the stomach, has gained attention with its ease of performance and cost savings potential over endoscopy. Endoscopic research concerning the efficacy of biopsy sites has revealed an increased sensitivity of antral biopsies over greater curvature biopsies for the detection of Helicobacter pylori. Fluoroscopically guided biopsies of the gastric mucosal are studied to determine whether such a difference between site sensitivity held true. If not, blind biopsy through a nasogastric tube, which traditionally samples only the greater curvature, might prove an even less expensive alternative.
  
  
  METHODS
  Seventy-two patients underwent nonendoscopic, fluoroscopically guided, mucosal biopsy of both the gastric antrum and the greater curvature of the stomach. Pathologic reports from both sites, using each patient as their own control, are compared to assess site sensitivity in the diagnosis of H. pylori gastritis.
  
  
  RESULTS
  The sensitivity for the detection of H. pylori gastritis by antral biopsy is 89%, whereas the sensitivity of greater curvature biopsy is 62%, The difference is considered clinically significant at P < or = 0.05.
  
  
  CONCLUSIONS
  This study confirms the need for antral biopsies when desiring a nonendoscopic approach to gastric mucosal sampling, in order to obtain a reasonable yield of data in dyspeptic patients with H. pylori gastritis. Blind techniques cannot reliably reach the antrum. Fluoroscopy can, and remains a less expensive alternative to endoscopy.
authors.affiliation: Armed Forces Institute of Pathology, Radiology-Pathology Division, Washington, DC 20306-6000, USA.
authors.forename: G N
authors.initials: GN
authors.lastname: Bender
authors.forename: D J
authors.initials: DJ
authors.lastname: Mullins
authors.forename: R S
authors.initials: RS
authors.lastname: Makuch
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods; D017046:Cost Savings; D003937:Diagnosis, Differential; D005260:Female; D005471:Fluoroscopy / Q000379:methods*; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D005756:Gastritis / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D013270:Stomach / Q000000981:diagnostic imaging