title: The role of striatal adenosine A2A receptors in regulation of the muscle tone in rats.
abstract: The aim of the present study was to assess contribution of striatal adenosine A2A receptors to regulation of the muscle tone in rats. The muscle tone was examined by a combined mechano- and electromyographic method, which measured simultaneously muscle resistance (MMG) of a rats hind foot to passive extension and flexion in the ankle joint and the electromyographic activity (EMG) of the antagonistic muscles: gastrocnemius and tibialis anterior. CGS 21680 (1 and 2 microg/0.5 microl), injected bilaterally into the rostral part of the striatum, dose-dependently increased both MMG and the EMG. The present results show that stimulation of striatal adenosine A2A receptors by CGS 21680 evokes parkinsonian-like muscle rigidity which may be due to activation of the GABAergic strio-pallidal pathway.
authors.affiliation: Department of NeuroPsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Kraków. wardas@if-pan.krakow.pl
authors.forename: J
authors.initials: J
authors.lastname: Wardas
authors.forename: J
authors.initials: J
authors.lastname: Konieczny
authors.forename: E
authors.initials: E
authors.lastname: Lorenc-Koci
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000843:Ankle Joint / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects; D004576:Electromyography; D008297:Male; D009127:Muscle Rigidity / Q000503:physiopathology*; D009129:Muscle Tonus / Q000187:drug effects* / Q000502:physiology; D010627:Phenethylamines / Q000494:pharmacology*; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017208:Rats, Wistar; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1 / Q000187:drug effects* / Q000502:physiology
chemical_list: D010627:Phenethylamines; D058906:Purinergic P1 Receptor Agonists; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine