Mammalian Dlx homeobox gene control of craniofacial and inner ear morphogenesis.
The Dlx homeobox gene family is of ancient origin, with apparent ancestral developmental functions in both nervous system regionalization and appendage (limb) outgrowth. Additional roles in inner ear and craniofacial development were likely acquired by the Dlx gene family during the course of animal evolution. Loss-of-function genetic mutations generated in the mouse have revealed a striking role for Dlx genes in patterning of the mammalian central nervous system, craniofacial structures and inner ear. Interestingly, none of the individual murine Dlx gene mutations to date have resulted in limb defects, suggesting a potentially significant developmental overlap of Dlx activity in this embryonic structure. J. Cell. Biochem. Suppls. 32/33:133-140, 1999.
Kraus
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Ronald O. Perleman Department of Dermatology, NYU School of Medicine, 550 First Avenue, New York, New York 10016, USA.
Lufkin
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D000818:Animals; D004423:Ear / Q000196:embryology*; D019143:Evolution, Molecular; D005147:Facial Bones / Q000196:embryology*; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox / Q000235:genetics / Q000502:physiology; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D009024:Morphogenesis; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology
C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors