Metabolite repression and inducer exclusion in the proline utilization gene cluster of Aspergillus nidulans.
The clustered prnB, prnC, and prnD genes are repressed by the simultaneous presence of glucose and ammonium. A derepressed mutation inactivating a CreA-binding site acts in cis only on the permease gene (prnB) while derepression of prnD and prnC is largely the result of reversal of inducer exclusion.
Cubero
B
B
Institut de Génétique et Microbiologie, Université Paris-Sud, UMR CNRS C8621, 91405 Orsay Cedex, France.
Gómez
D
D
Scazzocchio
C
C
D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D001233:Aspergillus nidulans / Q000235:genetics* / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005810:Multigene Family; D009154:Mutation; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics / Q000378:metabolism; D011392:Proline / Q000235:genetics* / Q000378:metabolism*; D011394:Proline Oxidase / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C079728:AreA protein, Aspergillus nidulans; D005656:Fungal Proteins; D014157:Transcription Factors; D011392:Proline; D050842:1-Pyrroline-5-Carboxylate Dehydrogenase; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011394:Proline Oxidase