title: Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.
abstract: The presence and distribution of Epstein-Barr virus (EBV), as well as human herpesvirus-6 and-8 (HHV-6 and HHV-8) was investigated by polymerase chain reaction in 191 samples from a variety of lymphoproliferative disorders. HHV-6 DNA was detected in 18% (30 of 169) of non-HHV-8 related lymphoproliferative disorders, with the highest frequency in AIDS-related lymphomas (8 of 25, 32%). In contrast, HHV-6 DNA was present in less than 5% (1 of 22) of HHV-8 related lymphoproliferative disorders [21 primary effusion lymphomas (PEL), and 1 cases of Castleman disease]. As compared to HHV-6, EBV DNA was frequently detected in PEL (11 of 19 samples, 58%). This study suggests that transformation to PEL is not enhanced by HHV-6, furthermore HHV-6 and -8 may interfere with each other.
authors.affiliation: Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA.
authors.forename: H
authors.initials: H
authors.lastname: Asou
authors.forename: T
authors.initials: T
authors.lastname: Tasaka
authors.forename: J W
authors.initials: JW
authors.lastname: Said
authors.forename: M
authors.initials: M
authors.lastname: Daibata
authors.forename: N
authors.initials: N
authors.lastname: Kamada
authors.forename: H P
authors.initials: HP
authors.lastname: Koeffler
mesh_terms: D005871:Castleman Disease / Q000453:epidemiology / Q000821:virology; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D015897:Comorbidity; D004279:DNA, Viral / Q000302:isolation & purification; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000453:epidemiology; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity; D015654:Herpesvirus 6, Human / Q000302:isolation & purification* / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology / Q000821:virology; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000821:virology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000453:epidemiology / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000453:epidemiology / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology*; D014762:Viral Interference
chemical_list: D004279:DNA, Viral