Immunohistochemical study of annexin V expression in placentae of preeclampsia.
We investigated the clinical significance of annexin V in the placentae with preeclampsia and found: (1) annexin V was detected on trophoblasts in the placentae and the staining intensity of annexin V in the placentae from such patients was reduced when compared to normal placentae; (2) as expression of annexin V was reduced, the gestosis index from patients with preeclampsia was elevated and the standard deviation value in the infant's standard weight was decreased; plasma level of the fibrin degradation products and thrombin-antithrombin III complex from patients were elevated as the expression of anexin V was reduced. These results suggest that the reduced expression of annexin V in the placentae from patients with preeclampsia may lead to a hypercoagulable state in the intervillous space and may be associated with the development of intrauterine growth restriction.
Shu
F
F
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Sugimura
M
M
Kanayama
N
N
Kobayashi
H
H
Kobayashi
T
T
Terao
T
T
D017304:Annexin A5 / Q000032:analysis*; D000990:Antithrombin III / Q000032:analysis; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D010447:Peptide Hydrolases / Q000032:analysis; D010920:Placenta / Q000737:chemistry*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
D017304:Annexin A5; D005338:Fibrin Fibrinogen Degradation Products; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases