title: [Association of TAP1/TAP2 gene polymorphism with inflammatory urogenital diseases combined with joint diseases].
abstract: OBJECTIVE
  To study association of TAP1/TAP2 gene polymorphism with urogenital infections combined with joint lesions.
  
  
  METHODS
  Of 139 patients examined 45 ones had inflammation caused by Chlamydia trachomatis (17 had joint disease), 42 had Mycoplasma hominis infection (joint lesions in 17 cases). Method of amplification was used on the basis of specific primers (ARMS).
  
  
  RESULTS
  Patients infected with C. trachomatis significantly more frequently had allele TAP1-02011 and TAP2-0201 (RR = 18.5, p < 0.01 and RR = 4.61, p < 0.05, respectively). Joint lesion in patients with chlamydial infection was associated with allele TAP1-02011 (RR = 11.92, p < 0.05). In mycoplasmosis association with joint lesions there is a significant link of joint syndrome with heterogeneous combination threonine/alanine in gene TAP2 position 565 (RR = 4.22, p < 0.05).
  
  
  CONCLUSIONS
  The findings can be used for predicting the joint syndrome development in patients with urogenital infection.
authors.forename: M L
authors.initials: ML
authors.lastname: Sartakova
authors.forename: V I
authors.initials: VI
authors.lastname: Konenkov
authors.forename: A V
authors.initials: AV
authors.lastname: Shevchenko
authors.forename: O V
authors.initials: OV
authors.lastname: Golovanova
authors.forename: L P
authors.initials: LP
authors.lastname: Konenkova
authors.forename: E V
authors.initials: EV
authors.lastname: Zonova
authors.forename: M A
authors.initials: MA
authors.lastname: Korolev
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D026905:Amino Acid Transport Systems; D001170:Arthritis, Infectious / Q000150:complications / Q000235:genetics / Q000382:microbiology*; D002690:Chlamydia Infections / Q000150:complications / Q000235:genetics / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000235:genetics* / Q000276:immunology; D017931:DNA Primers / Q000737:chemistry; D004269:DNA, Bacterial / Q000032:analysis; D005095:Exoribonucleases / Q000235:genetics*; D005260:Female; D052776:Female Urogenital Diseases / Q000150:complications / Q000235:genetics / Q000382:microbiology*; D005656:Fungal Proteins / Q000235:genetics; D005819:Genetic Markers; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D052801:Male Urogenital Diseases; D009175:Mycoplasma Infections / Q000150:complications / Q000235:genetics / Q000382:microbiology; D019535:Mycoplasma hominis / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D026905:Amino Acid Transport Systems; D017931:DNA Primers; D004269:DNA, Bacterial; D005656:Fungal Proteins; D005819:Genetic Markers; D029701:Saccharomyces cerevisiae Proteins; C429825:TAT2 protein, S cerevisiae; C071692:TAP2 protein, human; D005095:Exoribonucleases