title: Haemodynamic responses and changes of haemostatic risk factors in cold-adapted humans.
abstract: Epidemiological studies have shown an increase in acute myocardial infarctions or deaths due to myocardial infarction in colder weather; the mechanisms most likely involve increased blood levels of haemostatic risk factors, and increases in arterial blood pressure and heart rate. We studied the relationship between cold adaptation, haemostatic risk factors and haemodynamic variables. Cold adaptation was obtained by a programme of immersion of the whole body up to the neck in a water-filled bath, the temperature of which was gradually decreased from 22 degrees C to 14 degrees C, time of exposure being increased from 5 to 20 min over a period of 90 days. We studied 428 patients (44% men) and measured blood levels of fibrinogen, plasminogen activator inhibitor 1 (PAI-1), tissue plasminogen activator antigen (t-PA), plasma viscosity, von Willebrand factor, D-dimer and platelet count, both at baseline and after 90 days of daily immersion. There were significant reductions in von Willebrand factor (-3%; p < 0.001), and plasma viscosity (-3.0 s; p < 0.001), and a mild but significant increase in PAI-1 (+0.3 IU/ml; p = 0.02). The pressure rate product (systolic blood pressure x heart rate) was also significantly lower after cold adaptation (-310; p = 0.004). Cold adaptation, compared with exposure to cold weather, induces different haemodynamic responses and changes of blood levels of haemostatic risk factors.
authors.affiliation: Thrombosis Research Institute, London, UK. dlorenzo@tri-london.ac.uk
authors.forename: F
authors.initials: F
authors.lastname: De Lorenzo
authors.forename: Z
authors.initials: Z
authors.lastname: Kadziola
authors.forename: M
authors.initials: M
authors.lastname: Mukherjee
authors.forename: N
authors.initials: N
authors.lastname: Saba
authors.forename: V V
authors.initials: VV
authors.lastname: Kakkar
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D001809:Blood Viscosity; D003080:Cold Temperature; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006131:Growth Inhibitors / Q000032:analysis; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006487:Hemostasis; D006801:Humans; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000032:analysis; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D010976:Platelet Count; D012307:Risk Factors; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D006131:Growth Inhibitors; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D017395:Plasminogen Activator Inhibitor 1; D014841:von Willebrand Factor; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator