Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice.
Genes implicated in consumption of a bitter compound, sucrose octaacetate (SOA), were investigated using a full genomic scanning strategy. For a 0.1 mM concentration, two QTL reached 5.8 and 6.5 lod scores on chromosomes 2 (77 cM) and 11 (14 cM), respectively. For a 1 mM concentration, the Soa linkage on chromosome 6 (58 cM, lod score 9.4) was replicated, and another QTL was found on chromosome 19 (15 cM, lod score 3.2). Candidacy of previously identified genes in the close vicinity of the peak of the QTL was examined.
Le Roy
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I
UPR CNRS 9074, Génétique, neurogénétique, comportement, Institut de transgénose, Orléans, France.
Pager
J
J
Roubertoux
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PL
D000818:Animals; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB; D011110:Polymorphism, Genetic; D013395:Sucrose / Q000031:analogs & derivatives*; D013649:Taste / Q000235:genetics*
C026879:sucrose octaacetate; D013395:Sucrose