title: [Mixed retinal thrombosis in a patient carrying prothrombin gene mutation in a homozygote state].
abstract: We reported a case of a thrombosis of the retinal and central artery and vein in a 44-year-old patient, with high-grade T-cell lymphoma. Cardiovascular family history and a medical history of cerebral ischemia caused by in situ fibrinolysis, led to perform thorough hematologic and genetic examinations. These disclosed a prothrombin gene G 20210 a variant in a homozygous state. In a heterozygous state, this mutation leads to an increase in plasma prothrombin rate of the order of 30%. Therefore, it is considered to be a major risk factor for venous thrombotic disease. Otherwise, acute leukemia or non-Hodgkin's lymphoma may induce thrombosis of retinal artery and vein by means of an optic nerve infiltration, as well as beta-thalassemia, ocular trauma and retrobulbar anesthesia. Retinal central artery and vein are seldom both involved; whereas occlusions of their branches are more frequent.
authors.affiliation: Service d'Ophtalmologie, CHU Morvan, Brest.
authors.forename: F
authors.initials: F
authors.lastname: Kling
authors.forename: R
authors.initials: R
authors.lastname: Macarez
authors.forename: A
authors.initials: A
authors.lastname: Robinet
authors.forename: F X
authors.initials: FX
authors.lastname: Kouassi
authors.forename: J
authors.initials: J
authors.lastname: Colin
mesh_terms: D000328:Adult; D005451:Fluorescein Angiography; D006720:Homozygote; D006801:Humans; D016399:Lymphoma, T-Cell / Q000150:complications; D008297:Male; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D012170:Retinal Vein Occlusion / Q000209:etiology / Q000235:genetics*
chemical_list: D011516:Prothrombin