Antinociceptive and anti-inflammatory activity of Sida rhomboidea leaves.
Various organic extracts of Sida rhomboidea leaves were studied for antinociceptive and anti-inflammatory activity at a dose of 200 mg/kg. Ethyl acetate extract has shown significant (P < 0.01) antinociceptive activity. Percentage inhibition of edema by butanolic extract (33.05, P < 0.001) is comparable to that of phenylbutazone, 100 mg/kg inhibition (38.83%). Phytochemical screening of the extracts indicated the presence of alkaloids, steroids and/or triterpenoids and their glycosides, tannins, flavonoids and their glycosides, carbohydrates and absence of cardiac glycosides.
Venkatesh
S
S
J.S.S. College of Pharmacy, Rocklands, Ooty, India.
Reddy
Y S
YS
Suresh
B
B
Reddy
B M
BM
Ramesh
M
M
D000700:Analgesics / Q000302:isolation & purification / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002351:Carrageenan / Q000633:toxicity; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D007194:India; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010653:Phenylbutazone / Q000627:therapeutic use; D010936:Plant Extracts / Q000302:isolation & purification* / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan; D010653:Phenylbutazone