title: Extensive involvement of the myocardium and the cardiac conduction system in a case of Wegener's granulomatosis.
abstract: A 61-year-old female who had shown Raynaud's phenomenon and articular swelling for 10 years, was admitted to hospital because of fever of unknown origin (FUO) and dry cough. She was diagnosed by skin biopsy to have a collagen disease or overlap syndrome. Anemia developed rapidly and FUO persisted, but blood culture was negative. Although indomethacin and prednisolone were administered for the progression of clinical signs and symptoms, severe dyspnea developed, resulting in bradycardia, followed by recurrent episodes of ventricular tachycardia. In spite of extensive treatment for her arrhythmia she died on the 9th hospital day. An autopsy revealed generalized Wegener's granulomatosis with extensive cardiac involvement. Necrotizing angitis and severe granulomatous inflammatory foci affected characteristically the common bundle of His and right bundle branch in addition to the ordinary myocardium.
authors.affiliation: Division of Cardiology, Tokyo Metropolitan Geriatric Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohkawa
authors.forename: M
authors.initials: M
authors.lastname: Miyao
authors.forename: K
authors.initials: K
authors.lastname: Chida
authors.forename: T
authors.initials: T
authors.lastname: Mizuuchi
authors.forename: K
authors.initials: K
authors.lastname: Kida
authors.forename: K
authors.initials: K
authors.lastname: Takubo
authors.forename: K
authors.initials: K
authors.lastname: Ohtsubo
mesh_terms: D004562:Electrocardiography; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000473:pathology* / Q000503:physiopathology; D006329:Heart Conduction System / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*