title: Treatment of acute right coronary artery occlusion during anesthesia.
abstract: OBJECTIVE
  Perioperative coronary artery occlusion is a potentially dangerous complication causing myocardial infarction and circulatory collapse. We report a case showing severe ST segment depression in leads II and V5 during anesthesia. Diltiazem and nifedipine, but not nitroglycerine, partially improved the ST changes which were normalized by a percutaneous cardiopulmonary system (PCPS).
  
  
  METHODS
  A 71-yr-old man with cerebrovascular disease was scheduled for coronary artery bypass grafting (CABG). Past medical history included myocardial infarction due to right coronary artery (RCA) occlusion. Both the femoral artery and vein were cannulated percutaneously before operation and the PCPS was prepared as a back-up system. Depression of the ST segments in leads V5 and II was observed following heparinization. Although hemodynamic stability was maintained with continuous infusion of catecholamines, the ST changes were not improved by intravenous nitroglycerine. Intravenous diltiazem followed by nasal nifedipine partially improved the ST changes. The changes were normalized after induction of PCPS. No neurological complications were observed. The postoperative coronary angiography confirmed the total occlusion of RCA.
  
  
  CONCLUSIONS
  Calcium channel blockers were more effective than nitroglycerine in treating perioperative ST depression. However, none of them produced complete reversal of the ischemic changes which were normalized with PCPS.
authors.affiliation: Department of Anesthesiology, Osaka University Faculty of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Kagawa
authors.forename: I
authors.initials: I
authors.lastname: Yoshiya
authors.forename: N
authors.initials: N
authors.lastname: Hirata
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000208:Acute Disease; D000368:Aged; D000758:Anesthesia; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000628:therapy*; D004110:Diltiazem / Q000627:therapeutic use; D004562:Electrocardiography; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use
chemical_list: D004110:Diltiazem; D009543:Nifedipine