title: A normal livebirth after intracytoplasmic sperm injection for globozoospermia without assisted oocyte activation: case report.
abstract: The successful outcome of intracytoplasmic sperm injection (ICSI) with round-headed spermatozoa (globozoospermia) is reported. A couple with infertility secondary to globozoospermia received ICSI treatment. Fertilization, cleavage and pregnancy outcomes were recorded. This couple experienced 40, 10 and 42% fertilization rates after ICSI in their first, second and third cycles respectively. Pregnancy did not occur in the first or second cycle but was successfully achieved after the third ICSI cycle. It is concluded that current ICSI procedures may overcome the infertility associated with globozoospermia and result in normal healthy livebirth without assisted oocyte activation.
authors.affiliation: Assisted Conception Unit, Guy's and St Thomas' Hospitals Trust, Lambeth Palace Road, London SE1 7EH, UK.
authors.forename: S
authors.initials: S
authors.lastname: Stone
authors.forename: F
authors.initials: F
authors.lastname: O'Mahony
authors.forename: Y
authors.initials: Y
authors.lastname: Khalaf
authors.forename: A
authors.initials: A
authors.lastname: Taylor
authors.forename: P
authors.initials: P
authors.lastname: Braude
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000473:pathology / Q000628:therapy*; D008297:Male; D008854:Microscopy, Electron; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy; D013077:Sperm Head / Q000648:ultrastructure; D020554:Sperm Injections, Intracytoplasmic; D013082:Sperm Tail / Q000648:ultrastructure; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure; D016896:Treatment Outcome