Rheumatoid arthritis and its animal models: the role of TNF-alpha and the possible absence of specific immune reactions.
Rheumatoid arthritis is an organ-specific inflammatory disease of humans. Recent studies have focused on associations with non-MHC genes, new autoantigens and the role of innate immune responses. The success of anti-TNF-alpha in the majority (but, interestingly, not all) of patients has implications for disease mechanisms but the dangers of long-term therapy are becoming clearer. A number of new models of arthritis have been defined and emphasize the importance of the genetic make-up of the host. Attention has also focused on why the joint is a particularly vulnerable site for inflammatory responses.
Klareskog
L
L
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
McDevitt
H
H
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology*
D014409:Tumor Necrosis Factor-alpha