Dizocilpine pretreatment suppresses the action of hypoxia on hippocampal epileptic afterdischarges in immature rats.
Effect of dizocilpine (0.5 mg/kg i.p.) on epileptic afterdischarges elicited by low-frequency electrical stimulation of the dorsal hippocampus was studied in rat pups aged 12 and 18 days. Repeated elicitation of afterdischarges (ADs) in control animals resulted in a progressive increase of the duration of ADs in both age groups. Dizocilpine (MK-801) injected after the first afterdischarge suppressed this prolongation in 12-day-old rats only. Hypobaric hypoxia (simulated altitude of 9000 m for one hour) led to a marked prolongation of the first afterdischarge in both age groups with a tendency to shorter ADs after repeated stimulations. Dizocilpine potentiated this tendency in 12-day-old rat pups so that it became statistically significant. Administration of dizocilpine before hypoxia prevented the increase in duration of the first afterdischarge in both age groups.
Maresová
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Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Mares
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P
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004558:Electric Stimulation; D004569:Electroencephalography; D004827:Epilepsy / Q000517:prevention & control*; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018696:Neuroprotective Agents; D016291:Dizocilpine Maleate