title: Staged high-dose epinephrine clysis is safe and effective in extensive tangential burn excisions in children.
abstract: Prodigious blood loss commonly accompanies extensive tangential burn excisions. Staged high-dose epinephrine clysis may facilitate blood conserving excisional burn surgery. Prospective data was collected in 25 consecutive children who underwent tangential excision over the torso of at least 10% of the body surface with staged high dose epinephrine clysis. The children had an average age of 6.3 +/- 1.1 years and burn size of 45.7 +/- 3.9%. Total operative wound size (excision plus donor site) averaged 2 +/- 0.8% of the body surface. Total dose of epinephrine averaged 24.6 +/- 2.8 mcg/kg. Based on pre- and postoperative hematocrit and known volume of transfusion, the percent of the total blood volume lost per percent total wound generated averaged 0.98 +/- 0.19% of the blood volume per % of the body surface; 18 of the children (72%) required no blood in the perioperative period. There were no complications related to epinephrine use, graft take averaged 98 +/- 0.6% and all children survived and have been discharged home in good condition. Due to its rapid metabolism, subcutaneous epinephrine at high doses can be repetitively administered as long as time is allowed for its metabolism to occur. Use of this technique facilitates a marked reduction in blood requirements for these traditionally bloody operations.
authors.affiliation: Shriners Burns Hospital, Boston, MA, USA. sheridan.robert@mgh.harvard.edu
authors.forename: R L
authors.initials: RL
authors.lastname: Sheridan
authors.forename: S K
authors.initials: SK
authors.lastname: Szyfelbein
mesh_terms: D000293:Adolescent; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001810:Blood Volume; D002056:Burns / Q000097:blood / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D004733:Enema; D004837:Epinephrine / Q000008:administration & dosage*; D006400:Hematocrit; D006489:Hemostatic Techniques; D006801:Humans; D007223:Infant; D011446:Prospective Studies; D012449:Safety; D016038:Skin Transplantation; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D014662:Vasoconstrictor Agents; D004837:Epinephrine