Biocompatibility in vitro tests of Zinalco.
In this study, cultures of human lymphocytes were exposed for 48 h to aqueous suspensions of Zinalco, with different times of corrosion, to test the biocompatibility of this alloy and support its use in medical implants. The results show that the Zinalco concentrations assessed affect the mitotic index (MI) and some also increase the length of DNA migration measured in the comet assay in a significant manner; none of them showed clastogenic nor aneugenic effects. The authors conclude that Zinalco may be considered as an alternative biomaterial and suggest its use for short-term implants.
de los Angeles Aguilar
M
M
Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico, D.F., Mexico. maas@xanum.uam.mx
Espinosa
S
S
Rodríguez
L
L
Piña
C
C
D000328:Adult; D000497:Alloys / Q000633:toxicity*; D001672:Biocompatible Materials / Q000633:toxicity*; D002478:Cells, Cultured; D020552:Comet Assay; D004249:DNA Damage; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D008940:Mitotic Index / Q000187:drug effects
D000497:Alloys; D001672:Biocompatible Materials