Does hysteroscopy facilitate tumor cell dissemination? Incidence of peritoneal cytology from patients with early stage endometrial carcinoma following dilatation and curettage (D & C) versus hysteroscopy and D & C.
BACKGROUND
In several case reports, distension and irrigation of the uterine cavity during fluid hysteroscopy was suspected to cause tumor cell dissemination into the abdominal cavity in patients with endometrial carcinoma. It was the aim of this study to compare the incidence of positive peritoneal cytology in patients who underwent dilatation and curettage (D & C) with or without previous hysteroscopy.


METHODS
The authors conducted a multicentric, retrospective cohort analysis. One hundred thirteen consecutive patients with endometrial carcinoma treated between 1996 and 1997 were included. Endometrial carcinoma had to be limited to the inner half or less than the inner half of the myometrium (pathologic Stage IA,B). Positive peritoneal cytology was obtained during staging laparotomy. Patients underwent D & C either with or without prior diagnostic fluid hysteroscopy. No selection or randomization was applied to the two groups. Positive peritoneal cytology, defined as malignant or suspicious, was considered the primary statistical endpoint.


RESULTS
Peritoneal cytology was suspicious or positive in 10 of 113 patients (9%). The presence of suspicious or positive peritoneal cytology was associated with a history of hysteroscopy (P = 0.04) but not with myometrial invasion (P = 0.57), histologic subtype (P = 1.00) or grade (r = 0.16, P = 0.10), or the time between D & C and staging laparotomy (r = 0.04, P = 0.66).


CONCLUSIONS
Based on the limited extent of endometrial carcinoma in the current analysis, our data strongly suggest dissemination of endometrial carcinoma cells after fluid hysteroscopy. Determining whether a positive peritoneal cytology affects the prognoses of patients without further evidence of extrauterine disease will require longer follow-up.
Obermair
A
A
Division of Gynecology, Department of Gynecology and Obstetrics, University Hospital of Vienna, Vienna, Austria.
Geramou
M
M
Gucer
F
F
Denison
U
U
Graf
A H
AH
Kapshammer
E
E
Neunteufel
W
W
Frech
I
I
Kaider
A
A
Kainz
C
C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004107:Dilatation and Curettage / Q000009:adverse effects; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D015907:Hysteroscopy / Q000009:adverse effects* / Q000379:methods; D015994:Incidence; D008875:Middle Aged; D009366:Neoplasm Seeding; D009367:Neoplasm Staging; D010533:Peritoneal Lavage / Q000009:adverse effects*; D010534:Peritoneal Neoplasms / Q000209:etiology* / Q000556:secondary; D012189:Retrospective Studies