CPP antagonizes hypoxia-induced changes in dopamine metabolism in the striatum of newborn rat.
Treatment with 3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), a potent and competitive N-methyl-D-aspartate antagonist, is able to reduce the hypoxia-induced increase in striatal dopamine level by 26% even after the hypoxic insult has occurred. The hypoxia-induced decrease of the striatal 3,4-dihydroxyphenylacetic acid level can also be reversed by CPP. This study demonstrates that CPP can antagonize the hypoxia-induced changes in the dopamine metabolism in the striatum of the newborn rat.
Kuo
M F
MF
Department of Neurosurgery, National Taiwan University Hospital, Taipei.
Wu
R M
RM
Wang
H S
HS
Lin
S M
SM
D000818:Animals; D000831:Animals, Newborn; D004298:Dopamine / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D017072:Neostriatum / Q000187:drug effects* / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D010879:Piperazines; C050592:3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid; D004298:Dopamine