Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats.
In a previous study we showed that in normotensive male rats brain mineralocorticoid receptor blockade induced a long lasting decrease in blood pressure associated with increased urinary excretion of water and electrolytes. Here, we report the effect of intracerebroventricular injection of a mineralocorticoid receptor antagonist (RU28318; 3,3-oxo-7 propyl-17-hydroxy-androstan-4-en-17yl-propionic acid lactone) on cardiovascular and renal function in female rats. Compared with male rats, females are less sensitive to brain mineralocorticoid receptor blockade. Administration of RU28318 (10 ng, 100 ng) caused a significant decrease in systolic blood pressure (10-12.5%) only at 8 h after injection. An increased urinary excretion of water (about 160%) and electrolytes (about 175%) during the first 8 h after the injection was observed in the 100 ng RU28318 treated group. Heart rate, food intake and water consumption were not affected at either dose. In conclusion, in conscious female rats, brain mineralocorticoid receptors participate in blood pressure and renal function control.
Rahmouni
K
K
Institut de Pharmacologie, Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur, 11 rue Humann, 67085, Strasbourg, France.
Barthelmebs
M
M
Grima
M
M
Imbs
J L
JL
De Jong
W
W
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D002712:Chlorides / Q000652:urine; D003243:Consciousness; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D007668:Kidney / Q000187:drug effects* / Q000502:physiology; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000494:pharmacology; D013599:Systole; D014554:Urination / Q000187:drug effects
D002712:Chlorides; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; C041006:RU 28318; D012964:Sodium; D011188:Potassium