Regulation of glomerular cell number by apoptosis.
While commonly viewed as leading to glomerular scarring and end-stage renal failure, glomerular cell proliferation may be a beneficial response that promotes the injured glomerulus to return to its proper function. This brief review looks at the potentially counterbalancing influences that cause glomerular cells to survive, undergo mitosis, differentiate or die.
Savill
J
J
Division of Renal and Inflammatory Disease, School of Medical and Surgical Sciences, University of Nottingham, University Hospital, England, United Kingdom. j.savill@ed.ac.uk
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000473:pathology* / Q000503:physiopathology*; D007678:Kidney Glomerulus / Q000166:cytology*