title: Spinal cord swelling preceding syrinx development. Case report.
abstract: The pathophysiology of syrinx development is controversial. The authors report on a patient with progressive cervical myelopathy and a Chiari I malformation in whom spinal cord swelling preceded, by a few months, the development of a syrinx in the same location. The patient underwent a craniocervical decompressive procedure and duraplasty, and complete resolution of cord swelling and syringomyelia was achieved. This report is consistent with the theory that patients with Chiari I malformation have increased transmural flow of cerebrospinal fluid, which causes spinal cord swelling that later coalesces into a syrinx. The pathophysiology of syrinx development from spinal cord edema and the success of surgical decompressive treatments that do not invade the central nervous system support the prompt treatment of patients with spinal cord edema who are at risk for the development of a syrinx.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh, Presbyterian University Hospital, Pennsylvania, USA.
authors.forename: E I
authors.initials: EI
authors.lastname: Levy
authors.forename: J D
authors.initials: JD
authors.lastname: Heiss
authors.forename: M S
authors.initials: MS
authors.lastname: Kent
authors.forename: C J
authors.initials: CJ
authors.lastname: Riedel
authors.forename: E H
authors.initials: EH
authors.lastname: Oldfield
mesh_terms: D001139:Arnold-Chiari Malformation / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D004487:Edema / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D013595:Syringomyelia / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery