title: Neonatal skin care: the scientific basis for practice.
abstract: OBJECTIVE
  To review the literature addressing the care of neonatal skin.
  
  
  METHODS
  Computerized searches in MEDLINE and CINAHL, as well as references cited in articles reviewed. Key concepts in the searches included neonatal skin differences; neonatal skin and care practices for skin integrity; neonatal skin and toxicity; permeability; and contact irritant sensitization.
  
  
  METHODS
  Articles and comprehensive works relevant to key concepts and published after 1963, with an emphasis on new findings from 1993 to 1999. One hundred two citations were identified as useful to this review.
  
  
  METHODS
  Data were extracted and organized under the following headings: anatomy and physiology of the skin; physiologic and anatomic differences in neonatal skin; nutritional deficiencies; skin care practices; and care of skin breakdown.
  
  
  RESULTS
  Newborns' skin is at risk for disruption of normal barrier function because of trauma. In light of available evidence about differences in neonatal skin development, clinical practice guidelines are suggested for baths, lubrication, antimicrobial skin disinfection, and adhesive removal. In addition, basic care practices are suggested for maintaining skin integrity, reducing exposure to potentially toxic substances, and promoting skin health beyond the neonatal period. Preventive care recommendations are made for reducing trauma, protecting the skin's immature barrier function, and promoting skin integrity.
  
  
  CONCLUSIONS
  This review generated evidence with which to create a new and comprehensive practice guideline for clinicians. Evaluation of the guideline is under way at 58 U.S. sites.
authors.affiliation: Children's Hospital, Oakland, CA 94609, USA.
authors.forename: C
authors.initials: C
authors.lastname: Lund
authors.forename: J
authors.initials: J
authors.lastname: Kuller
authors.forename: A
authors.initials: A
authors.lastname: Lane
authors.forename: J W
authors.initials: JW
authors.lastname: Lott
authors.forename: D A
authors.initials: DA
authors.lastname: Raines
mesh_terms: D001494:Baths / Q000379:methods / Q000451:nursing; D019317:Evidence-Based Medicine; D006801:Humans; D007231:Infant, Newborn / Q000502:physiology; D017283:Neonatal Nursing / Q000379:methods* / Q000592:standards; D017410:Practice Guidelines as Topic; D017592:Skin Care / Q000379:methods* / Q000451:nursing* / Q000592:standards; D012879:Skin Physiological Phenomena