Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting.
A modular system for high-output solid-phase combinatorial synthesis has been designed and developed. The system employs three technological innovations to achieve its high efficiency and reliability: (1) application of microreactors as the reaction units in solid-phase synthesis; (2) use of radiofrequency tagging as the non-chemical tracking method; and (3) development of the directed sorting technology for split & pool synthesis. The system has been successfully applied in the synthesis of compound libraries of several hundred to several thousand compounds in multi-milligrams per compound quantity by many organizations.
Xiao
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XY
IRORI, a Discovery Partners International Company, 9640 Towne Centre Drive, San Diego, California 92121, USA.
Li
R
R
Zhuang
H
H
Ewing
B
B
Karunaratne
K
K
Lillig
J
J
Brown
R
R
Nicolaou
K C
KC
D002625:Chemistry, Organic / Q000295:instrumentation* / Q000379:methods; D019992:Databases as Topic; D015195:Drug Design; D007202:Indicators and Reagents; D009930:Organic Chemicals / Q000138:chemical synthesis*; D017239:Paclitaxel / Q000031:analogs & derivatives / Q000138:chemical synthesis; D011846:Radio Waves; D012116:Resins, Plant
D007202:Indicators and Reagents; D009930:Organic Chemicals; D012116:Resins, Plant; D017239:Paclitaxel