Interaction between Toxoplasma gondii and enterocyte.
Enterocyte is the first cell to be invaded by Toxoplasma gondii when ingested parasites are released from cysts or oocysts within the gastrointestinal tract. Our data showed that the transcytotic pathway of IgA could interfere with intracellular replication of T. gondii. On another hand, IFN-gamma could activate enterocyte and inhibit the parasite replication through an iron-dependent mechanism.
Bout
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Equipe associée INRA d'Immunologie Parasitaire, Faculté de Pharmacie, Tours, France.
Moretto
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Dimier-Poisson
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Gatel
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DB
D000818:Animals; D000913:Antibodies, Protozoan / Q000494:pharmacology; D020895:Enterocytes / Q000187:drug effects / Q000276:immunology / Q000469:parasitology*; D006801:Humans; D007070:Immunoglobulin A / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D014122:Toxoplasma / Q000187:drug effects / Q000254:growth & development*
D000913:Antibodies, Protozoan; D007070:Immunoglobulin A; D007371:Interferon-gamma; D007501:Iron