Evidence for the improvement of noninsulin-dependent diabetes mellitus in KKAy mice with daily oral administration of bis(6-methylpicolinato)oxovanadium(IV) complex.
A vanadyl complex, bis(6-methylpicolinato)oxovanadium(IV), VO(6MPA), with VO(N2O2) coordination mode, was found to exhibit a normoglycemic effect on KKAy mice with hereditary noninsulin-dependent diabetes mellitus with daily oral administration.
Fujisawa
Y
Y
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Japan.
Sakurai
H
H
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006946:Hyperinsulinism / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D051379:Mice; D008817:Mice, Mutant Strains; D009942:Organometallic Compounds / Q000627:therapeutic use*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; C402804:bis(6-methylpicolinato)oxovanadium(IV)