Resection of a Langerhans cell histiocytosis granuloma of the hypothalamus: case report.
The natural course and optimal treatment for isolated hypothalamic Langerhans cell histiocytosis (LCH) are unknown. We describe an adult female in whom total resection of a hypothalamic LCH granuloma was performed 12 years after transphenoidal resection of a pituitary adenoma. A retrospective review of the histological specimen of the first operation revealed CD1a positive cells characteristic of LCH along with a plurihormonal adenoma 12 years earlier. No other manifestations of LCH were found and MRI of the brain at the last follow-up 4 years after surgery did not show any recurrent or additional lesion. The diagnosis of isolated hypothalamic LCH is only possible by biopsy and our case demonstrates the feasability of a gross total resection in certain cases.
Czech
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Department of Neurosurgery, University of Vienna Medical School, Austria.
Mazal
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PR
Schima
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D005260:Female; D006099:Granuloma / Q000473:pathology / Q000601:surgery*; D006646:Histiocytosis, Langerhans-Cell / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000601:surgery; D015175:Prolactinoma / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed