Shaking, chills, and rigors with once-daily gentamicin.
A patient receiving once-daily gentamicin experienced shaking, chills, and rigors. This adverse reaction has occurred in patients around the country at many different institutions. Although the etiology is thought to be mediated by higher than normal endotoxin levels in one product, other possibilities must be explored.
Lucas
K H
KH
Department of Pharmacy, School of Clinical Pharmacy and Medicine, West Virginia University-Charleston Division, USA.
Schliesser
S H
SH
O'Neil
M G
MG
D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects; D004716:Endometritis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D005334:Fever / Q000139:chemically induced; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D009127:Muscle Rigidity / Q000139:chemically induced*; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy; D012768:Shivering / Q000187:drug effects*; D014202:Tremor / Q000139:chemically induced*
D005839:Gentamicins