title: Fluoride concentration in whole saliva and separate gland secretions after topical treatment with three different fluoride varnishes.
abstract: Fluoride concentration in whole saliva and in separate gland secretions was determined after a single application of each of 3 different fluoride varnishes with contrasting levels of fluoride in a randomized crossover design. The study group comprised 8 healthy schoolchildren aged 10-12 years treated with A: Bifluorid 12 (6% F); B: Duraphat (2.26% F); and C: Fluor Protector (0.1% F). Unstimulated and stimulated whole saliva, as well as stimulated parotid and submandibular-sublingual saliva, were collected at baseline and 1, 6, 12, and 24h after the varnish treatments. The fluoride concentrations were determined with an ion-selective electrode. Time- and dose-dependent concentration curves were obtained in all the collected secretions, A > B > C. In whole saliva, the fluoride levels were significantly elevated (P<0.01) 1 h after the A and B varnish applications compared with baseline, while the increase was insignificant for varnish C. Similar patterns were unveiled in the parotid and submandibular-sublingual secretions, although the increase in fluoride concentration was modest. The elevated levels did not exceed 6 h for any of the varnish tested. The results of this study suggest a correlation between the concentration of fluoride of the varnish and fluoride levels obtained in saliva after application.
authors.affiliation: Department of Pediatric Dentistry, Centre for Oral Health Sciences, Malmö University, Sweden. svante.twetman@lthalland.se
authors.forename: S
authors.initials: S
authors.lastname: Twetman
authors.forename: K
authors.initials: K
authors.lastname: Sköld-Larsson
authors.forename: T
authors.initials: T
authors.lastname: Modéer
mesh_terms: D002124:Calcium Fluoride / Q000008:administration & dosage; D018592:Cross-Over Studies; D004338:Drug Combinations; D005459:Fluorides / Q000032:analysis*; D005460:Fluorides, Topical / Q000008:administration & dosage*; D006801:Humans; D017736:Ion-Selective Electrodes; D007764:Lacquer; D010306:Parotid Gland / Q000378:metabolism; D011140:Polyurethanes / Q000008:administration & dosage; D012463:Saliva / Q000737:chemistry*; D012821:Silanes / Q000008:administration & dosage; D012969:Sodium Fluoride / Q000008:administration & dosage; D013361:Sublingual Gland / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism
chemical_list: C094502:Bifluorid 12; D004338:Drug Combinations; D005460:Fluorides, Topical; D011140:Polyurethanes; D012821:Silanes; C023807:sodium fluoride topical preparation; C022599:Fluor Protector; D012969:Sodium Fluoride; D002124:Calcium Fluoride; D005459:Fluorides