title: Effect of a 7-tesla homogeneous magnetic field on mammalian cells.
abstract: When two types of mammalian cells, mouse leukemia cells, P388, and Chinese hamster fibroblast cells, V79, were grown under a 7-tesla (T) homogeneous magnetic field which was produced by a newly constructed superconducting magnet biosystem (SBS), the growth pattern of cells under 7 T magnetic field and the geomagnetic field control showed no differences. The DNA distribution of the two cells was compared by flow cytometry after exposure to 7 T for 3 and 24 h, but there was no significant differences between magnet-exposed cells and unexposed cells. When the two types of cells were exposed to different concentrations of the antitumor agent, bleomycin (BLM), for 3 h under 7 T, their viable cell numbers were almost the same as that of the control although sensitivity to BLM was different between the two cells. These results suggest that the 7 T homogeneous magnetic field exerts no adverse effects on mammalian cells.
authors.affiliation: Research Laboratory of Resources Utilization, Tokyo Institute of Technology, Yokohama, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakurai
authors.forename: K
authors.initials: K
authors.lastname: Okuno
authors.forename: A
authors.initials: A
authors.lastname: Kubo
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Shoda
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000378:metabolism; D005434:Flow Cytometry; D008280:Magnetics; D051379:Mice; D011830:Radiation Effects; D014407:Tumor Cells, Cultured
chemical_list: D004247:DNA