Oxidant-induced apoptosis of glomerular cells: intracellular signaling and its intervention by bioflavinoid.
Oxidant stress plays a crucial role in the generation of a wide range of glomerular disease. In the first part of this article, we describe intracellular signaling pathways involved in the oxidant-initiated apoptosis of mesangial cells, especially highlighting the tyrosine kinase-c-Jun/AP-1 pathway. In the second part, we address a novel potential of bioflavonoid quercetin as an inhibitor of apoptosis in glomerular cells. Possible mechanisms for the antiapoptotic action of quercetin and its therapeutic utility are discussed.
Kitamura
M
M
Department of Medicine, University College London Medical School, England, United Kingdom. m.kitamura@medicine.ucl.ac.uk
Ishikawa
Y
Y
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000166:cytology*; D016877:Oxidants / Q000633:toxicity*; D011794:Quercetin / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*
D005419:Flavonoids; D016877:Oxidants; D011794:Quercetin