Coordinate regulation of Fos and Jun proteins in mouse brain by LiCl.
Expression of the bZIP transcription factor c-Fos in the nucleus tractus solitarius (NTS) of the brain stem may allow for genomic encoding of an unconditioned stimulus (US) during taste aversion learning. Dimerization of c-Fos with other bZIP proteins of the Jun family is necessary to enable transcriptional efficacy at the AP-1 sequence of putative target gene promoter regions. The present study examined the regulation of Fos and Jun proteins by LiCl. Double immunofluorescence labelling revealed that LiCl causes a coordinate upregulation of c-Fos, FosB and JunB, and these proteins are colocalized in a majority of cells examined in NTS, parabrachial nucleus (PBN), and central nucleus of the amygdala (CeA). This study demonstrates that a coordinate signalling response occurs in relevant brain regions in response to LiCl.
Swank
M W
MW
Department of Psychology, Furman University, Greenville, SC 29613, USA.
D000679:Amygdala / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D018021:Lithium Chloride / Q000494:pharmacology*; D008297:Male; D051379:Mice; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000187:drug effects; D017552:Solitary Nucleus / Q000187:drug effects / Q000378:metabolism; D013649:Taste / Q000502:physiology; D015854:Up-Regulation / Q000187:drug effects
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D018021:Lithium Chloride