A cyclodextrin dimer with a photocleavable linker as a possible carrier for the photosensitizer in photodynamic tumor therapy.
A cyclodextrin dimer has been synthesized with two beta-cyclodextrins linked by a flexible chain containing a carbon-carbon double bond. This dimer binds and solubilizes a phthalocyanine-based photosensitizer that generates singlet oxygen on irradiation. When the complex is irradiated, the singlet oxygen cleaves the carbon-carbon link, and the cyclodextrins are released, liberating the photosensitizer into the light path. Ideas about how this phenomenon could be used to make photodynamic tumor therapy into a more selective process are described.
Ruebner
A
A
Department of Chemistry, Columbia University, New York, NY 10027, USA.
Yang
Z
Z
Leung
D
D
Breslow
R
R
D000970:Antineoplastic Agents / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D019281:Dimerization; D004337:Drug Carriers / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry*
D000970:Antineoplastic Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; C013647:phthalocyanine