Synthesis of some pyridine ribosides and their biological activity.
A synthesis of 1-(beta-D-ribofuranosyl)-pyridin-2-thiones via reaction of 3-cyanopyridin-2(1H)-thiones with 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide under basic conditions, followed by hydrolysis with methanolic ammonia is reported.
Attia
A M
AM
Department of Chemistry, Faculty of Education, Tanta University, Kafr El- Sheikh, Egypt.
Mansour
H A
HA
Almehdi
A A
AA
Abbasi
M M
MM
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000737:chemistry*; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013601:T-Lymphocytes / Q000821:virology
D019380:Anti-HIV Agents; D011725:Pyridines; D012263:Ribonucleosides; C023666:pyridine