[The effect of tularemia live vaccine on contrasuppression of lymphocytes in patients with cancer of the corpus uteri during combined therapy and long term].
A significant decrease in the percentage of women showing contrasuppression of blood lymphocytes, as compared with control, was identified (p < 0.1); it was particularly low at terminal stages (III-IV). Surgery and subsequent radiotherapy were followed by further inhibition, particularly in terminally-ill patients. Two or three years after treatment, the numbers of patients in all stage groups showing contrasuppression increased, reaching the initial, i.e. lower than normal, levels. However, contrasuppression indices rose to normal in patients immunized with tularemia live vaccine (p > 0.05). This effect was observed in patients of all stage groups, immunized prior to treatment, on days 15-20 after immunization. Normal levels of contrasuppression were maintained during treatment and 2-3 years on. Both contrasuppression level and stage of tumor may serve as a criterion of gravity of disease and prognosis.
Movsesian
M A
MA
V.A. Fanarjian Center for Oncology Research, Ministry of Health of the Republic of Armenia, Yerevan.
Adamian
R T
RT
Markosian
K M
KM
D001428:Bacterial Vaccines / Q000494:pharmacology*; D003131:Combined Modality Therapy; D005260:Female; D005604:Francisella tularensis / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009367:Neoplasm Staging; D011379:Prognosis; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D014613:Vaccines, Attenuated / Q000494:pharmacology*
D001428:Bacterial Vaccines; D014613:Vaccines, Attenuated