title: Clinical and economic effectiveness of an inpatient anticoagulation service.
abstract: We conducted a prospective cohort study to evaluate clinical and economic end points achieved by a pharmacist-managed anticoagulation service compared with usual care (50 patients/group). The primary therapeutic end point was the time between starting heparin therapy and surpassing the activated partial thromboplastin time therapeutic threshold. The primary economic end point was the direct variable cost of hospitalization from admission to discharge. No significant differences between groups were noted for the primary therapeutic end point. Total hospital costs were significantly lower for patients receiving pharmacist-managed care than for those receiving usual care ($1594 and $2014, respectively, 1997 dollars, p=0.04). Earlier start of warfarin (p=0.05) and shorter hospital stay (5 and 7 days, p=0.05) were associated with the pharmacist-managed group.
authors.affiliation: Institute for Clinical Evaluation Sciences and the University of Toronto, Ontario, Canada.
authors.forename: M M
authors.initials: MM
authors.lastname: Mamdani
authors.forename: E
authors.initials: E
authors.lastname: Racine
authors.forename: S
authors.initials: S
authors.lastname: McCreadie
authors.forename: C
authors.initials: C
authors.lastname: Zimmerman
authors.forename: T L
authors.initials: TL
authors.lastname: O'Sullivan
authors.forename: G
authors.initials: G
authors.lastname: Jensen
authors.forename: P
authors.initials: P
authors.lastname: Ragatzki
authors.forename: J G
authors.initials: JG
authors.lastname: Stevenson
mesh_terms: D000925:Anticoagulants / Q000191:economics / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D017721:Hospital Costs; D006801:Humans; D007902:Length of Stay / Q000191:economics; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010607:Pharmacy Service, Hospital; D011655:Pulmonary Embolism / Q000188:drug therapy; D013997:Time Factors; D020246:Venous Thrombosis / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin