[Effects of an ATP-sensitive K+ channel activator, JTV-506, on antigen-induced early and late asthmatic responses in sensitized guinea pigs].
Effects of an ATP-sensitive K+ channel activator, JTV-506, on dual asthmatic responses and airway inflammation after antigen inhalation challenge were investigated in asthma model of guinea pigs. The animals were given an oral dose of 1 mg/kg of JTV-506 or vehicle (0.5% carboxymethyl cellulose sodium) 1 hour before and 3 hours after antigen inhalation challenge. Measurement of pulmonary resistance for 6 h was followed by bronchoalveolar lavage. After antigen challenge, all guinea pigs in the vehicle group displayed dual-phase airway obstruction and accumulation of eosinophils in the airways. After the treatment with JTV-506, the early asthmatic response was significantly inhibited, although the late asthmatic response or the recruitment of eosinophils into the airways were not inhibited. Therefore, we suggested that JTV-506 may inhibit airway smooth contraction induced by chemical mediators, but not function of CD4+ T lymphocytes.
Liu
Y
Y
1st Department of Internal Medicine, Tohoku University School of Medicine.
Tamura
G
G
Iijima
H
H
Shirato
K
K
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D002839:Chromans / Q000494:pharmacology*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D008297:Male; D015221:Potassium Channels / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D002839:Chromans; C107494:JTV 506; D015221:Potassium Channels; D014665:Vasodilator Agents