title: [Callosotomy in the treatment of "catastrophic" drug-resistant epilepsy in children].
abstract: The aim of this paper was to assess the preliminary results of callosotomy in children with "catastrophic" drug-resistant epilepsy. During the last 5 years, we performed callosotomy in 8 cases. Indications were: "catastrophic" drug-resistant epilepsy with frequent seizures, progressive psychomotor and intellectual deterioration, generalised structural and functional abnormalities in neuroimaging and neurophysiological studies. These children were of the mean age of 6 years, with the mean duration of illness 58 months. In the mean follow-up time of 27 months the following results were obtained: Engel class II--3 cases; class III--4 cases and class IV--1 case. Any intellectual improvement was noted in 2 cases only.
  
  
  CONCLUSIONS
  (1) callosotomy effectively reduces the frequency and severity of seizures in children with drug-resistant epilepsy; (2) in spite of reduced seizures, in the majority of cases no significant psychomotor and/or intellectual improvement was achieved; (3) callosotomy did not produce any permanent morbidity.
authors.affiliation: Kliniki Neurochirurgii Instytutu Pomnika-Centrum Zdrowia Dziecka w Warszawie-Miedzylesiu.
authors.forename: P
authors.initials: P
authors.lastname: Daszkiewicz
authors.forename: D
authors.initials: D
authors.lastname: Dabrowski
authors.forename: M
authors.initials: M
authors.lastname: Bachański
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D003337:Corpus Callosum / Q000601:surgery*; D018450:Disease Progression; D004351:Drug Resistance; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D011596:Psychomotor Disorders / Q000209:etiology; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants