nm23: unraveling its biological function in cell differentiation.
Tumor suppressor genes have a pivotal role in normal cells regulating cell cycle processes negatively. Furthermore, the inhibition of cell proliferation is a crucial step in the achievement of cell differentiation. Increasing evidence suggests that the nm23 genes, initially documented as suppressors of the invasive phenotype in some cancer types, are involved in the control of normal development and differentiation. In this review, we summarize some data concerning the involvement of the nm23 genes in development and differentiation, attempting to delineate an overall view of many facets of their biological role.
Lombardi
D
D
Dipartimento di Medicina Sperimentale, Università degli Studi di L'Aquila, L'Aquila, Italy. lombardi@ifo.it
Lacombe
M L
ML
Paggi
M G
MG
D000375:Aging / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D020559:Monomeric GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005810:Multigene Family; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D017385:Sequence Homology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins