Gelatin-containing diphtheria-tetanus-pertussis (DTP) vaccine causes sensitization to gelatin in the recipients.
Gelatin-specific T cell response was performed to determine whether a series of vaccinations with gelatin-containing DTP is a primary sensitization process in gelatin allergy. Thirty-seven recipients with gelatin-containing DTP who developed adverse reactions after vaccination and eight recipients of DTP without gelatin who also developed adverse reactions were studied. In addition, 10 subjects receiving gelatin-containing vaccine and 10 subjects inoculated with non-gelatin vaccine who did not show any adverse reactions were also investigated. All subjects inoculated with gelatin-containing DTP vaccine showed positive T cell responses against gelatin, however, occurrence of adverse reactions did not correlate with T cell responses. We conclude that DTP vaccine containing gelatin induces sensitization to gelatin in the recipients, but the mechanism of local reactions remains unknown.
Kumagai
T
T
Pediatric Allergy and Infectious Diseases Society of Sapporo, Kumagai Pediatric Clinic, W-6, Momijidai, Atsubetsu-ku, 004-0013, Sapporo, Japan. tkuma@mb.infosnow.ne.jp
Ozaki
T
T
Kamada
M
M
Igarashi
C
C
Yuri
K
K
Furukawa
H
H
Wagatuma
K
K
Chiba
S
S
Sato
M
M
Kojima
H
H
Saito
A
A
Okui
T
T
Yano
S
S
D002648:Child; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005780:Gelatin / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007223:Infant; D007376:Interleukin-2 / Q000096:biosynthesis; D008213:Lymphocyte Activation
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D007376:Interleukin-2; D007073:Immunoglobulin E; D005780:Gelatin