title: Validating a decision support system for anti-epileptic drug treatment. Part II: adjusting anti-epileptic drug treatment.
abstract: A model of expertise for monitoring antiepileptic drug treatment was implemented in a decision support system. We validated the advice of the system regarding treatment decisions at first follow-up with 265 paper cases based on patient records. The reference for comparison is based on the opinions of neurologists. We found considerable variation among the decisions of five neurologists. It could be shown that the system agreed with (groups of) neurologists at least as often as individual neurologists did. The correctness of the system was consistently higher than that of each of the neurologists, when the majority decision of the remaining neurologists constituted the standard.
authors.affiliation: Department of Medical Informatics, University of Maastricht, The Netherlands. raymond.smeets@mi.unimaas.nl
authors.forename: R
authors.initials: R
authors.lastname: Smeets
authors.forename: J
authors.initials: J
authors.lastname: Talmon
authors.forename: H
authors.initials: H
authors.lastname: Meinardi
authors.forename: A
authors.initials: A
authors.lastname: Hasman
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D003657:Decision Making; D020000:Decision Support Systems, Clinical; D016903:Drug Monitoring; D004827:Epilepsy / Q000188:drug therapy* / Q000517:prevention & control; D005103:Expert Systems; D005500:Follow-Up Studies; D006801:Humans; D008499:Medical Records; D009462:Neurology; D015588:Observer Variation; D012986:Software Validation
chemical_list: D000927:Anticonvulsants