title: Novel intertypic recombinants of epstein-barr virus in the chinese population.
abstract: Among 34 Epstein-Barr virus isolates from nonimmunocompromised Chinese donors, we identified three intertypic recombinants with type 1 sequences at the EBNA2 locus and type 2 sequences at some or all of the EBNA3A, -3B, and -3C loci. These appear to have arisen from independent, evolutionarily recent recombination events; such events may be commoner in nonimmunocompromised populations than hitherto imagined.
authors.affiliation: CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.forename: R S
authors.initials: RS
authors.lastname: Midgley
authors.forename: N W
authors.initials: NW
authors.lastname: Blake
authors.forename: Q Y
authors.initials: QY
authors.lastname: Yao
authors.forename: D
authors.initials: D
authors.lastname: Croom-Carter
authors.forename: S T
authors.initials: ST
authors.lastname: Cheung
authors.forename: S F
authors.initials: SF
authors.lastname: Leung
authors.forename: A T
authors.initials: AT
authors.lastname: Chan
authors.forename: P J
authors.initials: PJ
authors.lastname: Johnson
authors.forename: D
authors.initials: D
authors.lastname: Huang
authors.forename: A B
authors.initials: AB
authors.lastname: Rickinson
authors.forename: S P
authors.initials: SP
authors.lastname: Lee
mesh_terms: D001483:Base Sequence; D001782:Blood Donors; D002681:China; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000235:genetics*; D005838:Genotype; D004854:Herpesvirus 4, Human / Q000145:classification* / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D014763:Viral Matrix Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics
chemical_list: C402641:EBNA-2 protein, Human herpesvirus 4; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D014763:Viral Matrix Proteins; D014764:Viral Proteins