Possible role of normal development in carcinogenesis.
Apart from intercellular communication and co-operation, the selection pressure on the initiated cells to give rise to a malignant clone seems to depend on the developmental status of the target organ as well as the growing capacity of the prospective tumour. According to our theoretical approach, slowly growing tumours are counter selected and unable to survive in rapidly growing normal tissue.
Kozma
L
L
Department of Pathology, University Medical School of Debrecen, Hungary. dklpath@lib.dote.hu
István
E
E
D000375:Aging / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008954:Models, Biological