Pharmacotechnical caracterization and effectiveness study of a dermopharmaceutical form: rosemary honey contributions as a moisturizing active.
We have designed, elaborated and studied a dermopharmaceutical form formulated on the basis of a modern self-emulsifying excipient and rosemary honey (known as Miel de La Alcarria--Spain--according to the Governing Council), in order to obtain a hight degree of cutaneous hydratation. The formulation is typified and characterized from a pharmacotechnical and rheological points of view. In this sense, the experimental protocol has emphasized rheological essays which give relevant practical information. Also, we have performed a complete study of it physical and structural stability, and, lastly, we evaluated the dermopharmaceutical effectiveness. The work plan included the following tests: 1) Pharmacotechnical Essays--organoleptic characteristics, photomicrograh study, type of interposition, pH-determination, rheological and thixotropic study and physical stability tests; 2) Dermopharmaceutical Effectiveness Assays--Corneometric and Sebumetric measurements. From the results, we have deduced that the emulsified binary system that is proposed, stable from a physical and structural points of view, presents confirmed properties and a very good cosmetological adequation. In this sense, our emulsion presents a high degree of moisturizing/emollient power that qualifies it not only as a magnificent eudermic dermopharmaceutical form, but also as a very appropriate vehicle for Dermopharmaceutical and/or Dermatological Formulation.
Jiménez Soriano
M M
MM
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid, Spain.
Fresno Contreras
M J
MJ
Sellés Flores
E
E
D003879:Dermatologic Agents / Q000737:chemistry / Q000494:pharmacology*; D005079:Excipients; D019686:Lamiaceae / Q000737:chemistry*
D003879:Dermatologic Agents; D005079:Excipients