title: Selective plasma hydrolysis of glucocorticoid gamma-lactones and cyclic carbonates by the enzyme paraoxonase: an ideal plasma inactivation mechanism.
authors.affiliation: Medicinal Chemistry, Enzyme Pharmacology, Biomet Doscovery and Potein Science Units, Glaxo Wellcome Research and Development, Medicines Research Centre, Hertsfordshire, UK. kb0903@ggr.co.uk
authors.forename: K
authors.initials: K
authors.lastname: Biggadike
authors.forename: R M
authors.initials: RM
authors.lastname: Angell
authors.forename: C M
authors.initials: CM
authors.lastname: Burgess
authors.forename: R M
authors.initials: RM
authors.lastname: Farrell
authors.forename: A P
authors.initials: AP
authors.lastname: Hancock
authors.forename: A J
authors.initials: AJ
authors.lastname: Harker
authors.forename: W R
authors.initials: WR
authors.lastname: Irving
authors.forename: C
authors.initials: C
authors.lastname: Ioannou
authors.forename: P A
authors.initials: PA
authors.lastname: Procopiou
authors.forename: R E
authors.initials: RE
authors.lastname: Shaw
authors.forename: Y E
authors.initials: YE
authors.lastname: Solanke
authors.forename: O M
authors.initials: OM
authors.lastname: Singh
authors.forename: M A
authors.initials: MA
authors.lastname: Snowden
authors.forename: R J
authors.initials: RJ
authors.lastname: Stubbs
authors.forename: S
authors.initials: S
authors.lastname: Walton
authors.forename: H E
authors.initials: HE
authors.lastname: Weston
mesh_terms: D043303:Aryldialkylphosphatase; D002254:Carbonates / Q000097:blood / Q000737:chemistry*; D004950:Esterases / Q000097:blood*; D005938:Glucocorticoids / Q000097:blood / Q000737:chemistry*; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D007783:Lactones / Q000097:blood / Q000737:chemistry*; D008168:Lung / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D002254:Carbonates; D005938:Glucocorticoids; D007783:Lactones; D011355:Prodrugs; D004950:Esterases; D043303:Aryldialkylphosphatase