title: Effects of phosphate injection on metabolic and hormonal responses to exercise in fructose-injected rats.
abstract: The purpose of the present study was to evaluate the effects of an intraperitoneal injection of sodium phosphate on the metabolic and hormonal responses to exercise. Fructose-injected rats were either injected with sodium phosphate (Na2HPO4) or NaCl, either in a fed or in a food-restricted state (24 h), and evaluated at rest or after a 30-min exercise period (26 m/min; 0% grade). Liver ATP, phosphate (Pi), and glycogen concentrations were, on the whole, significantly (p < 0.05) higher in Na2HPO4 than in NaCl groups. Exercise resulted in a significant (p < 0.01) decrease in liver ATP and glycogen levels in fed and food-restricted rats whether injected with NaCl or Na2HPO4. Exercise, after NaCl and Na2HPO4 injection, resulted in a significant (p < 0.01) increase in liver phosphate and Pi/ATP ratio, and in a decrease in glucose and an increase in glucagon levels in food-restricted rats only. The normal exercise-induced increase in plasma FFA, glycerol, and norepinephrine levels (p < 0.05), observed in both fed and food-restricted NaCl-injected rats, was abolished by the injection of phosphate. The data are in line with the new concept that in addition to blood glucose levels, the increase in liver Pi/ATP ratio could also contribute to the increase in glucagon response during exercise.
authors.affiliation: Département de kinésiologie, Université de Montréal, Québec, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Ghanbari-Niaki
authors.forename: F
authors.initials: F
authors.lastname: Désy
authors.forename: J M
authors.initials: JM
authors.lastname: Lavoie
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005632:Fructose / Q000494:pharmacology*; D006728:Hormones / Q000097:blood*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008660:Metabolism / Q000502:physiology*; D010710:Phosphates / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006728:Hormones; D008112:Liver Glycogen; D010710:Phosphates; D005632:Fructose; D000255:Adenosine Triphosphate; C018279:sodium phosphate; D020155:3-Hydroxybutyric Acid