title: Morphometry of the canine prostate vasculature.
abstract: Morphometric data of the tissue vasculature are fundamental to the development of models for blood perfused tissue mass and heat transfer. Vascular casts of six canine prostates were made and morphometry was performed on 14 transverse sections. The region sampled was restricted to the midsection within the parenchyma. General vascular features that were observed include the radially arranged arteries and veins within the parenchyma, the axially oriented periurethral venous plexae, and the parenchymal arteries ramifying less than the veins. The arterial and venous lumen diameters (mean +/- SD) are 84 +/- 31 (N = 42) and 125 +/- 51 (N = 117), respectively. The lengths for a single vessel generation are 2147 +/- 1196 microm (N = 14) and 1265 +/- 693 microm (N = 39) for the arteries and veins, respectively. Intervessel distances are 4056 +/- 2350 microm (N = 33) between arteries, 1526 +/- 982 microm (N = 330) between veins, and 1498 +/- 874 microm (N = 108) between arteries and veins. A simple vasculature model of evenly distributed vessels imbedded in tissue for heat transfer analysis was developed. The artery-artery distance being about three times that of the vein-vein distance suggested a rete-like configuration of arteries surrounded by veins. An effective distance of 1519 microm between vessels was used. Based upon this vasculature model, the vessel density was calculated to be 5.6 arteries/cm(2) and 44.5 veins/cm(2).
authors.affiliation: Biomedical Engineering Program, The University of Texas at Austin, Austin, Texas, 78712, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Yuan
authors.forename: K R
authors.initials: KR
authors.lastname: Holmes
authors.forename: J W
authors.initials: JW
authors.lastname: Valvano
mesh_terms: D000818:Animals; D001158:Arteries / Q000033:anatomy & histology* / Q000166:cytology; D002452:Cell Count; D004285:Dogs; D008297:Male; D008954:Models, Biological; D011467:Prostate / Q000033:anatomy & histology* / Q000098:blood supply*; D018709:Statistics, Nonparametric; D014680:Veins / Q000033:anatomy & histology* / Q000166:cytology