title: Adenoidal tissue mass as a clinical guide of disease evolution in vertically HIV-1 infected children.
abstract: BACKGROUND
  it is known that in early-stage HIV-induced disease there is a discrepancy between the levels of viral burden and virus replication in peripheral blood versus lymphoid organs. HIV disease is active in the lymphoid tissue throughout the period of clinical latency. However, it is not known how long term progression of HIV infection is influenced by short-term changes in the adenoidal size.
  
  
  OBJECTIVE
  To assess the reliability of adenoidal-nasopharyngeal (AN) ratio in predicting clinical evolution of pediatric HIV infection.
  
  
  METHODS
  lateral radiographs of the nasopharynx in 94 Caucasian children born to HIV-1-infected mothers ranged from 6 months to 15 years (60 children infected with HIV-1 and 34 without HIV infection), and in a control group of 692 normal children were evaluated to obtain the AN ratio in order to identify the relationship of AN profiles with different stages of the disease. Patients were rated regarding their clinical and immunological status according to the Center for Disease Control Classification.
  
  
  RESULTS
  statistically significant differences between the groups of HIV-1-infected children, seroreverters and controls in the AN ratio were found (P < 0.001). Moreover, significant differences were also found in individual children that correlated with clinical progression.
  
  
  CONCLUSIONS
  examination of radiographic changes in adenoidal size by AN ratio in relation to clinical status during one year period in the whole group showed strong prognostic value. These findings may have important implications in the design of therapeutic strategies.
authors.affiliation: Department of Othorhinolaryngology, Hospital Infantil Niño Jesús, Madrid, Spain.
authors.forename: M B
authors.initials: MB
authors.lastname: Benito
authors.forename: T H
authors.initials: TH
authors.lastname: Sampelayo
authors.forename: D
authors.initials: D
authors.lastname: Gurbindo
authors.forename: B S
authors.initials: BS
authors.lastname: Sánchez-Ramón
authors.forename: E M
authors.initials: EM
authors.lastname: Gómez
authors.forename: M A
authors.initials: MA
authors.lastname: Muñoz-Fernández
mesh_terms: D000234:Adenoids / Q000000981:diagnostic imaging* / Q000473:pathology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D015658:HIV Infections / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000276:immunology; D015497:HIV-1; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D009305:Nasopharynx / Q000000981:diagnostic imaging; D011859:Radiography; D016176:T-Lymphocyte Subsets