title: Analysis of HLA-DRB1 alleles in Japanese patients with chronic myelogenous leukemia.
abstract: To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA-DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA-DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA-DRB1 alleles and CML.
authors.affiliation: First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan. yasukawa@m.ehime-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Yasukawa
authors.forename: H
authors.initials: H
authors.lastname: Ohminami
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Inokuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Fujita
mesh_terms: D000483:Alleles; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007564:Japan; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D016044:Fusion Proteins, bcr-abl