title: Serotonin infusion in the SCN reduces casein ingestion in rats.
abstract: To compare food and water intakes, adult male Wistar rats were infused during 7 days with serotonin (5-HT, 2.5 nmol/24 h) or artificial cerebrospinal fluid (CSF) in the suprachiasmatic nucleus (SCN) in a three-way selection of macronutrient-rich diets. Nocturnal energy intake from the casein-rich diet was significantly lower during infusion of 5-HT than before infusion. Decrease in nocturnal casein consumption was significant in the middle dark phase. Within the infusion period, water intake was reduced by 5-HT infusion during the early, middle and late light phase. The present results reinforce the hypothesis of a serotonergic control of water intake and provide evidence for SCN 5-HT involvement in casein-specific dietary selection.
authors.affiliation: School of Dietetics and Human Nutrition, McGill University, Quebec, Canada. CXLT@MUSICA.MCGILL.CA
authors.forename: L
authors.initials: L
authors.lastname: Thibault
authors.forename: E
authors.initials: E
authors.lastname: Mok
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: C Y
authors.initials: CY
authors.lastname: Wong
mesh_terms: D000818:Animals; D002364:Caseins / Q000008:administration & dosage; D002940:Circadian Rhythm / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology*; D013493:Suprachiasmatic Nucleus / Q000187:drug effects*
chemical_list: D002364:Caseins; D012701:Serotonin