title: The dopamine D2 receptor gene is a susceptibility locus for Parkinson's disease.
abstract: The dopamine D2 receptor (DRD2) gene has been proposed as a candidate gene underlying several psychiatric and neurologic disorders. The aim of the present study was to examine if selected polymorphisms in the DRD2 gene are associated with Parkinson's disease (PD). We determined the allelic frequencies for four polymorphisms located in the DRD2 gene in a sample of 135 patients with PD and 202 normal control subjects. No significant difference was observed in the allelic frequencies between patients with PD and control subjects with regard to the -141C Ins/Del and the Ser311/Cys311 variants. On the contrary, the A1 allele of the TaqIA polymorphism and the B1 allele of the TaqIB polymorphism were more frequent in patients with PD than in control subjects (control subjects: TaqIA A1 = 14.6%, TaqIB B1 = 10.6%; patients with PD: TaqIA A1 = 20.7%, TaqIB B1 = 17.4%). Patients carrying the A1 allele or the B allele had an increased risk of developing PD (TaqIA, odds ratio: 1.71, 95% confidence intervals: 1.08-2.73; TaqIB, odds ratio: 1.83, 95% confidence intervals: 1.12-3.02). The TaqIA and TaqIB polymorphisms were in strong linkage disequilibrium, suggesting that these two polymorphisms convey the same information about the risk of presenting with PD. Genetic variation in the DRD2 gene may influence the risk of developing PD, thus confirming that the DRD2 gene is a susceptibility locus for PD.
authors.affiliation: Institute of Neurology, Department of Medical Sciences, University of Catanzaro, Italy.
authors.forename: R L
authors.initials: RL
authors.lastname: Oliveri
authors.forename: G
authors.initials: G
authors.lastname: Annesi
authors.forename: M
authors.initials: M
authors.lastname: Zappia
authors.forename: D
authors.initials: D
authors.lastname: Civitelli
authors.forename: E V
authors.initials: EV
authors.lastname: De Marco
authors.forename: A A
authors.initials: AA
authors.lastname: Pasqua
authors.forename: F
authors.initials: F
authors.lastname: Annesi
authors.forename: P
authors.initials: P
authors.lastname: Spadafora
authors.forename: A
authors.initials: A
authors.lastname: Gambardella
authors.forename: G
authors.initials: G
authors.lastname: Nicoletti
authors.forename: D
authors.initials: D
authors.lastname: Branca
authors.forename: M
authors.initials: M
authors.lastname: Caracciolo
authors.forename: U
authors.initials: U
authors.lastname: Aguglia
authors.forename: A
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000368:Aged; D000483:Alleles; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007558:Italy; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011446:Prospective Studies; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012306:Risk
chemical_list: D017448:Receptors, Dopamine D2