title: Beta-carotene generates thiobarbituric acid-reactive substances by interaction with nitrogen dioxide in air.
abstract: Generation of thiobarbituric acid-reactive substances (TBARS) from methyl linoleate in the exposure of nitrogen dioxide/air was inhibited by beta-carotene in a dose-dependent manner. However, introduction of nitrogen dioxide/air or oxygen into a solution of beta-carotene generated a significant amount of TBARS accompanying loss of its characteristic yellow color. Storing beta-carotene in a solid state at ambient temperatures in air generated a large amount of TBARS accompanying loss of its yellow color. TBARS from beta-carotene may interfere the measurement of TBARS from polyunsaturated fatty acids, and may give undesirable effects on biomaterials.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan. kikugawa@ps.toyaku.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Kikugawa
authors.forename: K
authors.initials: K
authors.lastname: Hiramoto
authors.forename: A
authors.initials: A
authors.lastname: Hirama
mesh_terms: D000388:Air; D005231:Fatty Acids, Unsaturated / Q000737:chemistry; D009585:Nitrogen Dioxide / Q000737:chemistry*; D013858:Thiobarbiturates / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis*; D019207:beta Carotene / Q000737:chemistry*
chemical_list: D005231:Fatty Acids, Unsaturated; D013858:Thiobarbiturates; D017392:Thiobarbituric Acid Reactive Substances; D019207:beta Carotene; C029684:thiobarbituric acid; D009585:Nitrogen Dioxide