title: Effects of haemolysis, lipaemia and bilirubinaemia on prothrombin time, activated partial thromboplastin time and thrombin time in plasma samples from healthy dogs.
abstract: Interferences caused by haemolysis, lipaemia and bilirubinaemia on prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT in normal canine plasma samples were studied using commercially available reagents and a steel ball coagulometer. Haemolysis significantly interfered with APTT (P = 0.0076) and TT (P = 0.0292). Regression analysis showed that TT was significantly shortened as haemoglobin concentrations increased. Lipaemia increased as demonstrated by regression analysis. Bilirubin significantly interfered with PT (P=0.0003) and APTT (P=0.002). Although statistically significant, none of the differences found were of clinical relevance.
authors.affiliation: Department of Animal Medicine, Faculty of Veterinary Medicine, Campus de Rabanales, Ctra. Madrid-Cádiz KM 396, Córdoba, 14014, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Moreno
authors.forename: P J
authors.initials: PJ
authors.lastname: Ginel
mesh_terms: D000818:Animals; D001780:Blood Coagulation Tests / Q000662:veterinary*; D004285:Dogs / Q000097:blood*; D006461:Hemolysis / Q000502:physiology*; D006932:Hyperbilirubinemia / Q000097:blood / Q000662:veterinary*; D008055:Lipids / Q000097:blood*; D010314:Partial Thromboplastin Time / Q000662:veterinary; D011517:Prothrombin Time / Q000662:veterinary; D013918:Thrombin Time / Q000662:veterinary; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides