Building inhibitory synapses: exchange factors getting into the act? [ comment].
Gephyrin is a synaptic protein that is required for clustering of glycine and GABAA receptors. Gephyrin itself may be regulated by a newly identified protein named collybistin.
Fallon
J R
JR
Department of Neuroscience, Brown University, Box 1953, 190 Thayer Street, Providence, Rhode Island 02912, USA. justin_fallon@brown.edu
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D020558:GTP Phosphohydrolases / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D009433:Neural Inhibition / Q000502:physiology*; D011963:Receptors, GABA-A / Q000378:metabolism; D064067:Rho Guanine Nucleotide Exchange Factors; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism*
C577403:Arhgef9 protein, mouse; D002352:Carrier Proteins; D020662:Guanine Nucleotide Exchange Factors; D008565:Membrane Proteins; D011963:Receptors, GABA-A; D064067:Rho Guanine Nucleotide Exchange Factors; C073441:gephyrin; D020558:GTP Phosphohydrolases; D005998:Glycine