Prevalence of factor V Leiden in patients with retinal vein occlusion.
OBJECTIVE
Factor V Leiden mutation is a common genetic defect associated with a tendency to venous thrombosis. The aim of this study was to evaluate the prevalence of factor V Leiden in patients with retinal vein occlusion (RVO).


METHODS
Blood samples were obtained from fifty RVO patients and were tested for factor V Leiden using DNA analysis. Twenty-three patients had central RVO (CRVO), twenty-five had branch RVO (BRVO) and two had CRVO in one eye and BRVO in the other eye.


RESULTS
DNA analysis showed that only 4 patients (8%) were heterozygous carriers of factor V Leiden. None of the patients were found to be homozygous. In the control group 11 (9.2%) were heterozygous carriers of factor V Leiden. The difference between the patients and the controls was not statistically significant.


CONCLUSIONS
There was no clear association between RVO and factor V Leiden in this pool of patients. Factor V Leiden does not seem to play an important role in the development of RVO.
Demirci
F Y
FY
Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Turkey. ykdemirci@yahoo.com
Güney
D B
DB
Akarçay
K
K
Kir
N
N
Ozbek
U
U
Sirma
S
S
Unaltuna
N
N
Ongör
E
E
D000328:Adult; D000368:Aged; D004247:DNA / Q000032:analysis; D005165:Factor V / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology / Q000235:genetics*; D013927:Thrombosis / Q000097:blood / Q000150:complications / Q000235:genetics
C095381:factor V Leiden; D005165:Factor V; D004247:DNA