Carboprost exposure in a newborn with recovery.
BACKGROUND
This case describes a newborn who was accidentally given carboprost (Hemabate) 250 micrograms intramuscularly, the largest amount ever reported in a normal newborn.


METHODS
A full-term newborn was inadvertently given carboprost rather than his prescribed hepatitis vaccine. Within 15 minutes, he was tachypneic and hypertensive followed by bronchospasms and dystonic movements and/or seizure activity of his upper extremities. He also was hyperthermic and had diarrhea stools. He recovered within 18 hours and was discharged.


CONCLUSIONS
The manufacturer reports 2 infants who received lesser amounts and remained asymptomatic. This child exhibited symptoms associated with an overdose of a prostaglandin F2a, although complete recovery occurred within 18 hours.
Mrvos
R
R
Pittsburgh Poison Center, Pennyslvania, USA. Mrvosr@chplink.chp.edu
Kerr
F J
FJ
Krenzelok
E P
EP
D002260:Carboprost / Q000008:administration & dosage / Q000506:poisoning*; D005334:Fever / Q000139:chemically induced; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008297:Male; D008508:Medication Errors; D010120:Oxytocics / Q000008:administration & dosage / Q000506:poisoning*
D010120:Oxytocics; D002260:Carboprost