[Effect of sodium hydroxybutyrate on carboxypeptidase H activity and on angiotensin-converting enzyme in different regions of the rat brain].
It is revealed, that analogue of the gamma-aminobutyric acid--sodium hydroxybutyrate causes decrease of activities carboxypeptidase H and angiotensin converting enzyme in pituitary gland, hypothalamus and striatum. The most expressed changes of enzyme activities were observed in pituitary gland and hypothalamus. The activity of carboxypeptidase H changes more essentially, than one of angiotensin converting enzyme. The assumption one of mechanisms of influence the hydroxybutyric acid and, possible, the gamma-aminobutyric acid, on neuropeptides level is changes of activity of enzyme of biologically active peptides exchange is expressed.
Vernigora
A N
AN
Penza State Pedagogical University, Russian Federation.
Gengin
M T
MT
Shchetinina
N V
NV
Spiridonov
D A
DA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D051381:Rats
D006885:Hydroxybutyrates; D002268:Carboxypeptidases; D007703:Peptidyl-Dipeptidase A; D043423:Carboxypeptidase H