Systemic endothelial function is preserved in men with both active and inactive variant angina pectoris.
To test the hypothesis that coronary spasm could be a coronary manifestation of systemic endothelial dysfunction and that the activity of coronary spasm could influence systemic endothelial function, we examined brachial flow-mediated, endothelium-dependent vasodilation and nitroglycerin-induced endothelium-independent vasodilation with high-resolution ultrasound in 11 men with variant angina pectoris (6 active and 5 inactive) without established coronary atherosclerosis. Endothelium-dependent vasodilation in peripheral circulation was preserved in men with active and inactive variant angina pectoris, suggesting that systemic endothelial dysfunction is not involved in either the pathogenesis or the activity of coronary spasm.
Ito
K
K
The First Department of Internal Medicine, Kobe University School of Medicine, Japan.
Akita
H
H
Kanazawa
K
K
Yamada
S
S
Shiga
N
N
Terashima
M
M
Matsuda
Y
Y
Takai
E
E
Iwai
C
C
Takaoka
H
H
Yokoyama
M
M
D000368:Aged; D000788:Angina Pectoris, Variant / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D005996:Nitroglycerin / Q000494:pharmacology; D015588:Observer Variation; D011379:Prognosis; D014463:Ultrasonography; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; D005996:Nitroglycerin