title: Development, formulation, and effectiveness testing of a silicone-based barrier-type hand cream.
abstract: We report the development, design, and results of effectiveness and acceptability testing of a hydrating, nutritive, barrier-type hand cream designed for severely damaged skin (including skin damaged by dermatological problems). We tested different silicone derivatives and a water-in-oil (W/O) silicone emulsifier to produce organoleptic qualities that would increase consumer acceptance of this type of W/O emulsion. Pharmacotechnical and effectiveness tests were done to check the stability and preservation of the formulas, their usefulness in improving dry skin, and acceptance by users. The results of pharmacotechnical testing were optimal. Although no active principle aimed specifically at dermatological problems was present in the final formulas, users reported notable subjective improvements in cracking and scaling.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Granada, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Baquerizo
authors.forename: V
authors.initials: V
authors.lastname: Gallardo
authors.forename: A
authors.initials: A
authors.lastname: Parera
authors.forename: M A
authors.initials: MA
authors.lastname: Ruiz
mesh_terms: D002626:Chemistry, Pharmaceutical; D003258:Consumer Behavior; D003872:Dermatitis / Q000188:drug therapy; D004355:Drug Stability; D004655:Emulsions; D006225:Hand; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009824:Ointments / Q000737:chemistry* / Q000627:therapeutic use; D012828:Silicones / Q000737:chemistry*; D017592:Skin Care; D011795:Surveys and Questionnaires
chemical_list: D004655:Emulsions; D009824:Ointments; D012828:Silicones