title: A short synthesis of troglitazone: an antidiabetic drug for treating insulin resistance.
abstract: Troglitazone was obtained in 5 steps from 4-bromo-1,1-dimethoxy-3-methylbut-2-ene with an overall yield of 7.5%. The formation of the chromane ring was achieved by condensing an unsaturated acetal with trimethylhydroquinone in the presence of bis(trifluoromethylsulfonyl)imide.
authors.affiliation: Laboratoire de Chimie Organique, associé au CNRS, ESPCI, Paris, France. janine.cossy.espci.fr.
authors.forename: J
authors.initials: J
authors.lastname: Cossy
authors.forename: C
authors.initials: C
authors.lastname: Menciu
authors.forename: H
authors.initials: H
authors.lastname: Rakotoarisoa
authors.forename: P H
authors.initials: PH
authors.lastname: Kahn
authors.forename: J R
authors.initials: JR
authors.lastname: Desmurs
mesh_terms: D002839:Chromans / Q000138:chemical synthesis*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D007333:Insulin Resistance; D013844:Thiazoles / Q000138:chemical synthesis*; D045162:Thiazolidinediones; D000077288:Troglitazone
chemical_list: D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077288:Troglitazone