title: Estrogen receptor-alpha mRNA variants in murine and human tissues.
abstract: A side-by-side comparison of several normal mouse and human tissues was undertaken in order to determine if exon-deleted variant ER-alpha mRNAs are expressed in the mouse. The data showed that the complex pattern of ER-alpha alternative splicing that is detected in multiple human tissues was not apparent in murine tissues. Only low levels of an exon-4 deleted ER-alpha transcript were detected in murine tissues, although multiple relatively abundant exon-deleted ER-alpha transcripts were detected in human tissues. The data support a species-specific difference in the expression of ER-alpha variant mRNAs between mouse and human.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Lu
authors.forename: H
authors.initials: H
authors.lastname: Dotzlaw
authors.forename: E
authors.initials: E
authors.lastname: Leygue
authors.forename: L J
authors.initials: LJ
authors.lastname: Murphy
authors.forename: P H
authors.initials: PH
authors.lastname: Watson
authors.forename: L C
authors.initials: LC
authors.lastname: Murphy
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D047628:Estrogen Receptor alpha; D005091:Exons; D005260:Female; D006801:Humans; D051379:Mice; D009928:Organ Specificity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013045:Species Specificity
chemical_list: D047628:Estrogen Receptor alpha; D012333:RNA, Messenger; D011960:Receptors, Estrogen