Successful in-vitro fertilization pregnancy with spermatozoa from a patient with Kartagener's syndrome: case report.
This paper reports on the successful treatment by in-vitro fertilization (IVF) of a couple in whom the male partner had Kartagener's syndrome. His spermatozoa were severely asthenozoospermic with deficient dynein arms and disordered microtubular configuration. On computer-assisted sperm analysis (CASA) motile spermatozoa displayed straight non-progressive motility with minimal amplitude of lateral head displacement and none were hyperactivated. This is the first case report in which spermatozoa with axonemal disruption in a man with immotile cilia syndrome (ICS) have been shown to be able to penetrate the zona pellucida and fertilize oocytes. IVF may be a suitable treatment for certain variants of ICS.
Kay
V J
VJ
Department of Obstetrics and Gynaecology, Royal Infirmary of Edinburgh, UK.
Irvine
D S
DS
D000328:Adult; D001369:Axons / Q000648:ultrastructure; D002923:Cilia / Q000648:ultrastructure; D004398:Dyneins / Q000032:analysis; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000628:therapy*; D007619:Kartagener Syndrome / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D008870:Microtubules / Q000648:ultrastructure; D011247:Pregnancy; D013076:Sperm Count; D013081:Sperm Motility; D013082:Sperm Tail / Q000648:ultrastructure; D013094:Spermatozoa / Q000002:abnormalities / Q000648:ultrastructure
D004398:Dyneins