5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa.
To examine the distribution of different polymorphisms in genes of the 5-HT system in patients with anorexia nervosa (AN) and bulimia nervosa (BN), we analyzed the distribution of a polymorphism (-1438G/A) and the presence of known mutations in 5-HT2A and 5-HT2C receptor genes in 168 Italian female patients affected by AN and BN. Patients with AN restricting type (ANr) only, unlike those with AN binge eating/purging type (ANp) and BN purging type (BNp), showed a statistically significant difference in 5-HT2A-1438A/A genotype frequency with respect to controls. With regard to the other polymorphisms, no differences were found in the studied groups with respect to controls. 5-HT2A promoter polymorphism is probably implicated in the susceptibility to eating disorders and its involvement is more significant in ANr, when compared with ANp and BNp.
Nacmias
B
B
Department of Neurological and Psychiatric Sciences, University of Florence, Italy.
Ricca
V
V
Tedde
A
A
Mezzani
B
B
Rotella
C M
CM
Sorbi
S
S
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000235:genetics*; D002032:Bulimia / Q000235:genetics*; D005260:Female; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin