Efficacy of vitamin E compared with either simvastatin or atorvastatin in preventing the progression of atherosclerosis in homozygous familial hypercholesterolemia.
Over a 4-year period, antioxidant therapy (vitamin E) was compared with high-dose statin therapy in 15 patients with homozygous familial hypercholesterolemia. Carotid intima-media thickness, used as an in vivo assessment of atherosclerosis, progressed rapidly during the period of vitamin E therapy but regressed on statin therapy.
Raal
F J
FJ
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa. 014fred@chiron.wits.ac.za
Pilcher
G J
GJ
Veller
M G
MG
Kotze
M J
MJ
Joffe
B I
BI
D000293:Adolescent; D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D000069059:Atorvastatin; D002339:Carotid Arteries / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004247:DNA / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D009154:Mutation; D011758:Pyrroles / Q000627:therapeutic use*; D011973:Receptors, LDL / Q000235:genetics; D019821:Simvastatin / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000473:pathology; D014810:Vitamin E / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D011758:Pyrroles; D011973:Receptors, LDL; D014280:Triglycerides; D014810:Vitamin E; D004247:DNA; D000069059:Atorvastatin; D019821:Simvastatin