Study of salivary response to continuous infusion of cerulein and secretin in healthy subjects.
OBJECTIVE
The effects of intravenous infusion of cerulein and secretin on the secretion and biochemical composition of whole saliva in humans were studied.


METHODS
A total of 33 subjects were divided into 3 groups, which underwent intravenous infusion with saline solution (NaCl 0.15 mol/L(-1)); saline solution, cerulein (1.25 x 10(-3) microg kg(-1) min(-1)), and cerulein supplemented with secretin (2.5 x 10(-2) clinical units kg(-1) min(-1)); and saline solution, secretin (2.5 x 10(-2) clinical units kg(-1) min(-1)), and secretin supplemented with cerulein (1.25 x 10(-3) microg kg(-1) min(-1)).


RESULTS
Cerulein reduced salivary flow rate, bicarbonate concentration and output, and protein output and increased amylase activity. The inhibitory effect of cerulein on salivary flow rate and bicarbonate concentration and output prevailed when an infusion of cerulein was supplemented with secretin. Cerulein and secretin acting together increased protein concentration. Secretin alone decreased salivary flow rate and bicarbonate concentration, whereas secretin supplemented with cerulein not only decreased salivary flow rate, bicarbonate concentration, and bicarbonate output but also increased protein concentration.


CONCLUSIONS
The effect of secretin and cerulein on salivary secretion and its composition is quite different from that observed in the pancreas.
Marcinkiewicz
M
M
Department of Physiology, Medical University of Bialystok, Poland.
Namiot
Z
Z
Stasiewicz
J
J
Gorski
J
J
D000328:Adult; D002108:Ceruletide / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012463:Saliva / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D012633:Secretin / Q000008:administration & dosage*; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors
D012633:Secretin; D002108:Ceruletide