title: Transient headache and impaired vision after intravenous thyrotropin-releasing hormone in a patient with pituitary macroadenoma.
abstract: We report a case of transient headache and impaired vision following administration of intravenous thyrotropin-releasing hormone (TRH) to a woman with a non-functioning pituitary macroadenoma, visual field defect, and elevated thyroid-stimulating hormone (TSH). The symptoms lasted for two hours and then resolved without known sequelae. There are a few other reported cases of similar adverse reactions to neuroendocrine manipulation in patients with pituitary macroadenomas. This is the second reported case of such adverse reactions to TRH alone and the first in which the patient had prior elevation of TSH.
authors.affiliation: Department of Medicine, Room B-313, Division of Endocrinology and Metabolism, Mount Sinai Services at Queens Hospital Center, 82-68 164 Street, Jamaica, NY 11432, USA.
authors.forename: I
authors.initials: I
authors.lastname: Sachmechi
authors.forename: R N
authors.initials: RN
authors.lastname: Bitton
authors.forename: D
authors.initials: D
authors.lastname: Patel
authors.forename: B S
authors.initials: BS
authors.lastname: Schneider
mesh_terms: D000236:Adenoma / Q000175:diagnosis*; D000368:Aged; D005260:Female; D006261:Headache / Q000139:chemically induced*; D006801:Humans; D010901:Pituitary Function Tests; D010911:Pituitary Neoplasms / Q000175:diagnosis*; D013973:Thyrotropin-Releasing Hormone / Q000009:adverse effects*; D013997:Time Factors; D014786:Vision Disorders / Q000139:chemically induced*
chemical_list: D013973:Thyrotropin-Releasing Hormone