Aldosterone secretion by the mid-gestation ovine fetus: role of the AT2 receptor.
This study shows a short-term (3 h) infusion of ACTH but not angiotensin II (Ang II) stimulates aldosterone production in the mid-gestation fetus. No synergistic effect between ACTH and Ang II was observed. The fetal response was significantly less than observed in the adult animal when infused in a similar manner. Interestingly, plasma aldosterone could be stimulated by Ang II in the presence of a specific AT2 receptor blocker. This suggests that the inability of Ang II to stimulate aldosterone may be due in part to Ang II binding to the AT2 receptor and limiting the amount of available Ang II and/or antagonising the effects of Ang II on the AT1 receptor.
Moritz
K M
KM
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Australia.
Boon
W C
WC
Wintour
E M
EM
D000311:Adrenal Glands / Q000737:chemistry / Q000196:embryology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000450:Aldosterone / Q000097:blood / Q000378:metabolism*; D000804:Angiotensin II / Q000819:agonists / Q000494:pharmacology; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D005260:Female; D005333:Fetus / Q000378:metabolism* / Q000502:physiology; D005865:Gestational Age; D007093:Imidazoles / Q000378:metabolism / Q000494:pharmacology; D011247:Pregnancy; D011725:Pyridines / Q000378:metabolism / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000502:physiology; D012756:Sheep / Q000033:anatomy & histology / Q000196:embryology*
D007093:Imidazoles; D011725:Pyridines; D012333:RNA, Messenger; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D000804:Angiotensin II; C073402:PD 123319; D000450:Aldosterone; D000324:Adrenocorticotropic Hormone; D003577:Cytochrome P-450 Enzyme System