title: Long-term survival after thoracoscopic lung volume reduction: a multiinstitutional review.
abstract: BACKGROUND
  It has been suggested that bilateral thoracoscopic lung volume reduction (BTLVR) yields significantly better long-term survival than unilateral thoracoscopic lung volume reduction (UTLVR).
  
  
  METHODS
  All perioperative data were collected at the time of the procedure. Follow-up data were obtained during office visits or by telephone.
  
  
  RESULTS
  A total of 673 patients underwent thoracoscopic LVR: 343 had either simultaneous or staged BTLVR and 330, UTLVR. As of July 1998, follow-up was available on 667 (99%) of the 673 patients with a mean follow-up of 24.3 months. The patients in the BTLVR group were significantly younger (62.6+/-8.0 years versus 65.4+/-8.1 years; p < 0.0001), had a higher preoperative arterial oxygen tension (69.7+/-12 mm Hg versus 65.3+/-11 mm Hg; p < 0.0001), and had a superior preoperative 6-minute walk performance (279.9+/-93.6 m [933+/-312 feet] versus 244.5+/-101.4 m [815+/-338 feet] p < 0.0001). There was no difference in the operative mortality rate between the two groups (UTLVR, 5.1%, and BTLVR, 7%). Actuarial survival rates for the UTLVR group at 1 year, 2 years, and 3 years were 86%, 75%, and 69%, respectively versus 90%, 81%, and 74%, respectively, for the BTLVR group (p = not significant).
  
  
  CONCLUSIONS
  Contrary to previous reports, survival after BTLVR was not superior to that after UTLVR even though the former group appeared to have a lower risk preoperatively because of younger age, higher arterial oxygen tension, more advantageous anatomy, and better functional status. Despite thoracoscopic LVR, the actuarial mortality rate approached 30% at 3 years, and this calls into question whether this procedure offers any survival advantage to patients with end-stage emphysema.
authors.affiliation: Division of Cardiothoracic Surgery, Saint Louis University, Missouri 63110-0250, USA. naunheim@slu.edu
authors.forename: K S
authors.initials: KS
authors.lastname: Naunheim
authors.forename: L R
authors.initials: LR
authors.lastname: Kaiser
authors.forename: J E
authors.initials: JE
authors.lastname: Bavaria
authors.forename: S R
authors.initials: SR
authors.lastname: Hazelrigg
authors.forename: M J
authors.initials: MJ
authors.lastname: Magee
authors.forename: R J
authors.initials: RJ
authors.lastname: Landreneau
authors.forename: R J
authors.initials: RJ
authors.lastname: Keenan
authors.forename: J F
authors.initials: JF
authors.lastname: Osterloh
authors.forename: T M
authors.initials: TM
authors.lastname: Boley
authors.forename: C A
authors.initials: CA
authors.lastname: Keller
mesh_terms: D000368:Aged; D002423:Cause of Death; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects / Q000401:mortality; D011183:Postoperative Complications; D011656:Pulmonary Emphysema / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D015656:Respiratory Mechanics; D015996:Survival Rate; D013906:Thoracoscopy