Molecular epidemiology of genital Chlamydia trachomatis infection in high-risk women in Senegal, West Africa.
The prevalence and heterogeneity of Chlamydia trachomatis infections in a cohort of female sex workers in Dakar (Senegal) were determined by using endocervical-swab-based PCR DNA amplification assays. The overall prevalence of cervical chlamydial infection was 28.5% (206 of 722), and most of these infections were asymptomatic. An increased number of sexual partners was significantly associated with infection (adjusted odds ratio [AOR] = 1.37; 95% confidence interval [CI] = 1.06 to 1.77), while the presence of a yeast infection was negatively associated with chlamydial infection (AOR = 0.28; 95% CI = 0.10 to 0.83). Six different C. trachomatis genotypes were identified based on phylogenetic analysis of the omp1 gene sequences. Interestingly, genotype E predominated (47.6%) and was not associated with visible signs of cervical inflammation compared to non-E genotypes (P < 0.05). Overall, the high rate of asymptomatic C. trachomatis infection by genotype E may suggest genotype-specific properties that confer a transmission advantage in this high risk population.
Sturm-Ramirez
K
K
Department of Immunology, Harvard School of Public Health and Harvard AIDS Institute, Boston, Massachusetts, USA.
Brumblay
H
H
Diop
K
K
Guèye-Ndiaye
A
A
Sankalé
J L
JL
Thior
I
I
N'Doye
I
I
Hsieh
C C
CC
Mboup
S
S
Kanki
P J
PJ
D000328:Adult; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics*; D002690:Chlamydia Infections / Q000453:epidemiology*; D002692:Chlamydia trachomatis / Q000145:classification / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005831:Genital Diseases, Female / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D017720:Molecular Epidemiology; D018272:Porins; D015995:Prevalence; D012307:Risk Factors; D012675:Senegal; D011477:Sex Work; D002575:Uterine Cervicitis / Q000209:etiology / Q000382:microbiology
D001425:Bacterial Outer Membrane Proteins; D018272:Porins; C071677:omp1 protein, Chlamydia trachomatis