Parameters of peroxidation and proteolysis in the organism of the liquidators of Chernobyl accident consequences.
The specificity of lung irradiation caused by ionizing radiation is influence on mucous membranes of respiratory ways, alveolar epithelium and capillaries of a small circle of the blood circulation. Under diseases of bronchus-lung system the lipid peroxidation (LPO) processes activation is observed. The radiating influence strengthening effect. In results in imbalance aggravation in system "LPO-antioxidants", and long expressing of LPO intensification is the important mechanism of the inflammation chronization. The sharp increase of proteolytic activity and inhibitor activity decrease is found out in the patients-liquidators. Noticed imbalance results in the further change of permeability of membranes and correlates with an index of endoscopy inflammation changes and index of irreversible changes in lung tissue. Thus, the direct connection between LPO intensity and imbalance degree of proteinase-inhibitor system of blood at the patients with chronic bronchitic taking part in Chernobyl accident liquidation is revealed.
Lykholat
E A
EA
Ukrainian State Research Institute of Medical-Social Problems of Invalids, Dniepropetrovsk.
Chernaya
V I
VI
D000328:Adult; D001980:Bronchi / Q000378:metabolism / Q000528:radiation effects; D001991:Bronchitis / Q000097:blood / Q000209:etiology / Q000378:metabolism; D001999:Bronchoscopy; D002908:Chronic Disease; D006801:Humans; D006868:Hydrolysis; D015227:Lipid Peroxidation; D008168:Lung / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D016273:Occupational Exposure; D011210:Power Plants; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D014455:Ukraine