title: [Sarcoid optic neuropathy].
abstract: Sarcoidosis is a multisystem granulomatous disease mostly involving the chest. Sarcoid optic neuropathy is an uncommon but serious manifestation that requires long-term corticosteroid treatment. We report here the case of a 50-year-old black patient complaining of a recent blurred vision on his left eye. The ophthalmologic examination was normal. Goldmann visual field and visual evoked potentials confirmed the diagnosis of retrobulbar optic neuropathy. Sarcoidosis was presumed on a chest radiography and computed tomography and confirmed with a transbronchial biopsy. Symptoms disappeared with intravenous bolus of corticosteroids. Three months later, without treatment, a right inferior eyelid tumor was observed. Magnetic resonance imaging (RMI) showed two orbital masses and multiple meningeal lesions enhancing with contrast suggesting neurosarcoidosis which decreased with a long-term high-dose corticosteroid therapy (1 mg/kg/d). Optic neuropathy is a rare manifestation of neurosarcoidosis, mostly accompanied by optic-disc involvement with papillary lesions. Chest roentgenogram and computed tomography give a presumption of sarcoidosis. But biopsy is mandatory to confirm the diagnosis demonstrating the histologic lesion of a non caseating granulomatous. Corticosteroid therapy is dramatically efficient but sometimes several months treatment is required.
authors.affiliation: Clinique Ophtalmologique Universitaire, Centre Hospitalier Intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil.
authors.forename: C
authors.initials: C
authors.lastname: Brindeau
authors.forename: A
authors.initials: A
authors.lastname: Glacet-Bernard
authors.forename: B
authors.initials: B
authors.lastname: Roualdes
authors.forename: I
authors.initials: I
authors.lastname: Abd Alsamad
authors.forename: H
authors.initials: H
authors.lastname: Oubraham
authors.forename: C
authors.initials: C
authors.lastname: Meyrignac
authors.forename: G
authors.initials: G
authors.lastname: Soubrane
mesh_terms: D044383:Black People; D005074:Evoked Potentials, Visual; D005260:Female; D005602:France; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009900:Optic Nerve / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D012507:Sarcoidosis / Q000150:complications / Q000503:physiopathology*; D014794:Visual Fields