title: Insulin-like growth factor 1 enhances renal function in a patient with chronic renal failure on peritoneal dialysis.
abstract: Insulin-like growth factor 1 (IGF1) has been shown to improve renal function in healthy subjects, as well as those with chronic renal failure. To our knowledge, IGF1 has not been shown to be efficacious in patients who were already undergoing dialysis. We present the case of a 70-year-old woman with end-stage renal disease (ESRD) and overt uremic symptoms treated with IGF1 after peritoneal dialysis was discontinued because of complications. There was a significant improvement in her inulin clearance during the course of treatment. The patient remained well and did not require dialytic support for 19 weeks. Although further data are necessary, we believe this case shows that IGF1 may be a short-term alternative to dialysis in patients with ESRD.
authors.affiliation: Renal Division, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
authors.forename: A
authors.initials: A
authors.lastname: Vijayan
authors.forename: S C
authors.initials: SC
authors.lastname: Franklin
authors.forename: J A
authors.initials: JA
authors.lastname: Delmez
authors.forename: S B
authors.initials: SB
authors.lastname: Miller
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000235:genetics / Q000628:therapy*; D007677:Kidney Function Tests; D010531:Peritoneal Dialysis, Continuous Ambulatory; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics; D016896:Treatment Outcome; D014511:Uremia / Q000097:blood / Q000235:genetics / Q000628:therapy
chemical_list: D007334:Insulin-Like Growth Factor I