[Proton-activated K+-channels of frog taste receptor cells].
It is conventionally accepted that sour transduction does not require a receptor mechanism and is based on a direct interaction of acid stimuli with apical ion channels. At the same time, it has been shown that a number of neuronal cells express H(+)-gated cation channels. We studied the effect of acid stimuli on ion currents recorded from frog Rana temporaria taste receptor cells and found that a substantial subpopulation of them exhibited K+ currents activated by extracellular protons. To our knowledge, this is the first demonstration of H(+)-gated K+ channels in cells of any type including taste receptor cells. These channels are presumably involved in sour transduction and/or contribute to intercellular communications between discoid cells.
Bobkov
Iu V
IuV
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Grishin
A A
AA
Rogachevskaia
O A
OA
Kolesnikov
S S
SS
D000818:Animals; D002450:Cell Communication; D015640:Ion Channel Gating; D017136:Ion Transport; D010812:Physical Stimulation; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000378:metabolism*; D011522:Protons; D011896:Rana temporaria; D015398:Signal Transduction; D013650:Taste Buds / Q000378:metabolism*
D026902:Potassium Channel Blockers; D015221:Potassium Channels; D011522:Protons