title: [Chronotherapeutic evaluation of the antihypertensive treatment].
abstract: Blood pressure, as well as other biological parameters, shows a circadian rhythm with a morning increase following the nocturnal blood pressure fall. In a parallel way, and probably related, there is a characteristic morning concentration of cardiovascular events. The antihypertensive treatment should pursue normotension during the 24 hours of the day, by restrictive the morning blood pressure increase. Drug efficacy can be improved depending on the time of the day of drug dose. Chronotherapeutical effects of different drugs in blood pressure are discussed.
authors.affiliation: Instituto de Farmacología y Toxicología, Ruprecht-Karts-Universidad de Heidelberg, Fakultät für Klinische Medizin, Alemania.
authors.forename: B
authors.initials: B
authors.lastname: Lemmer
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002940:Circadian Rhythm; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers