Physicochemical characterization of YJA20379-8, a new proton pump inhibitor.
The physicochemical properties of the potent reversible proton pump inhibitor YJA20379-8, 3-butyryl-4-[(R)-1-methylbenzylamino]-8-ethoxy-1,7-naphthyridine, were studied. YJA20379-8 is essentially nonhygroscopic pale yellowish crystalline powder. It is practically insoluble in water, and its lipid solubility is high. The pH solubility profile exhibits an L-shaped curve, indicating YJA20379-8 is a basic substance having a soluble ionized form in acidic conditions. This is consistent with the result of an experiment to determine pKa. The solid-state stability study shows that YJA20379-8 is stable at various temperatures and humidities, but is decomposed by light.
Kim
J
J
Department of Formulation, Yungjin Pharmaceutical Company, Hwasung-kun, Kyunggi-do, Korea.
Park
C
C
Chang
M
M
Cha
J
J
Lee
J
J
Chung
Y
Y
D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D009287:Naphthyridines / Q000737:chemistry* / Q000494:pharmacology*; D054328:Proton Pump Inhibitors; D012995:Solubility
C114511:3-butyryl-4-(5R-methylbenzylamino)-8-ethoxy-1,7-naphthyridine; D000897:Anti-Ulcer Agents; D009287:Naphthyridines; D054328:Proton Pump Inhibitors