title: The minimal genome concept.
abstract: Complete genome sequences are becoming available for a large number of diverse species. Quantification of gene content, of gene family expansion, of orthologous gene conservation, as well as their displacement, are now possible - laying the ground for the estimation of the minimal set of proteins sufficient for cellular life. The consensus of computational results suggests a set close to 300 genes. These predictions will be evaluated by engineering of small bacterial genomes.
authors.affiliation: Akkadix Corporation, La Jolla 92037, USA. mushegian@akkadix.com
authors.forename: A
authors.initials: A
authors.lastname: Mushegian
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D019295:Computational Biology; D017124:Conserved Sequence / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D005798:Genes, Bacterial / Q000235:genetics* / Q000502:physiology; D020745:Genome, Archaeal; D016680:Genome, Bacterial; D009154:Mutation / Q000235:genetics; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins