title: Endothelin and post-ganglionic sympathetic neurons.
abstract: 1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post-ganglionic sympathetic neuronal development. 2. Endothelin is produced by post-ganglionic neurons and by cells adjacent to these neurons. 3. Post-ganglionic sympathetic neurons express functional receptors for ET. 4. Endothelin promotes the survival of cultured post-ganglionic sympathetic neurons and modulates the morphological and biochemical differentiation of these neurons. 5. Endothelin enhances the activity of nerve growth factor and modulates the release of neurotransmitter from post-ganglionic sympathetic nerve terminals.
authors.affiliation: Department of Pharmacology, University of Vermont, Burlington 05405, USA. ddamon@zoo.uvm.edu
authors.forename: D H
authors.initials: DH
authors.lastname: Damon
mesh_terms: D000818:Animals; D016232:Endothelins / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D017779:Sympathetic Fibers, Postganglionic / Q000502:physiology*
chemical_list: D016232:Endothelins