Normal immune responses to ingested foods.
This is a short review of the literature with a bias toward the author's work. Small amounts of dietary antigens are taken up into the circulation. B-cell responses to foods (antibodies and antibody-secreting cells) occur as a physiological event locally and in the circulation in all three major immunoglobulin classes. A low levels of IgE is also a normal phenomenon. IgA anti-gliadin antibodies represent an exception. Antibody titers in general tend to decline with age. T-cell responses specific for foods are low in the circulation of healthy subjects. T-cell cytokines are more frequently produced in the gastrointestinal mucosa compared with the circulation. Results indicate that the phenomenon of oral tolerance takes place in humans. Oral tolerance within the T cell system may represent an important regulatory mechanism for normal immunity.
Husby
S
S
Department of Pediatrics, Odense University Hospital, Denmark.
D000941:Antigens / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D004064:Digestive System / Q000276:immunology; D005502:Food; D006801:Humans; D007108:Immune Tolerance; D007109:Immunity; D009055:Mouth / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens