title: A light-inactivated antibiotic.
abstract: Sodium 7beta-[(R)-2-(N(b)()-o-nitrobenzyloxycarbonyl)hydrazino-3-pheny lpropa namido]cephalosporanate (1) is described as a new type of beta-lactam antibiotic, which undergoes light-induced destruction of its beta-lactam moiety and hence becomes biologically inactive. This type of antibiotic holds the promise of self-destruction over a number of hours of exposure to light, so that it would not allow selection of resistance in the environment.
authors.affiliation: Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
authors.forename: W
authors.initials: W
authors.lastname: Lee
authors.forename: Z H
authors.initials: ZH
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Vakulenko
authors.forename: S
authors.initials: S
authors.lastname: Mobashery
mesh_terms: D001419:Bacteria / Q000187:drug effects; D002219:Carbamates / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D002511:Cephalosporins / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010777:Photochemistry
chemical_list: C403760:7-(2-(N(b)-2-nitrobenzyloxycarbonyl)hydrazino-3-phenylpropanamido)cephalosporanic acid; D002219:Carbamates; D002511:Cephalosporins