Overexpression of p53 and HER-2/neu and c-myc in primary fallopian tube carcinoma.
Primary fallopian tube carcinoma is a rare form of female cancer and the genetic basis of its carcinogenesis remains unclear. Eighteen cases of primary fallopian tube adenocarcinoma were studied. Immunohistochemical staining for p53, HER-2/neu and c-myc genes were performed. Overexpression of p53 was detected in 12 cases (67%), HER-2/neu in 16 cases (89%), and c-myc in 11 cases (61%). The potential relevance of overexpression of the three genes with clinicopathological features was examined, but no significant correlation was found. The high incidence of p53, HER-2/neu and c-myc overexpression in fallopian tube adenocarcinoma suggests these genes may play a role in its tumorigenesis.
Chung
T K
TK
Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, N.T., Hong Kong. tonychung@cuhk.edu.hk
Cheung
T H
TH
To
K F
KF
Wong
Y F
YF
D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology; D005185:Fallopian Tube Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005784:Gene Amplification; D015870:Gene Expression; D018734:Genes, erbB-2 / Q000235:genetics*; D016259:Genes, myc / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging