Effect of proton pump inhibitor alone or in combination with clarithromycin on mycobacterial growth in human alveolar macrophages.
The effect of omeprazole, a clinically used proton pump inhibitor, alone or in combination with clarithromycin was evaluated against Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium tuberculosis, using a human alveolar macrophage model of infection. Omeprazole exhibited no significant effect on the growth of the two M. avium complex strains or on the mycobactericidal activity of clarithromycin against them. In contrast, omeprazole significantly promoted the growth of Mycobacterium tuberculosis and the anti-mycobacterial activity of clarithromycin against it in human alveolar macrophages. It was speculated that intracellular acidic milieu around M. tuberculosis might be one reason for the lower activity of clarithromycin in the treatment of human tuberculosis.
Suzuki
K
K
Department of Infectious Disease, South-West Ward, Kyoto University Hospital, Sakyo-ku, Kyoto, Japan. ksuzuki@kuhp.kyoto-u.ac.jp
Tsuyuguchi
K
K
Matsumoto
H
H
Niimi
A
A
Tanaka
E
E
Amitani
R
R
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D017291:Clarithromycin / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D016676:Macrophages, Alveolar / Q000382:microbiology*; D008875:Middle Aged; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development*; D009853:Omeprazole / Q000494:pharmacology*; D010588:Phagosomes / Q000382:microbiology; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D017291:Clarithromycin; D009853:Omeprazole