Application of magnetic resonance techniques for imaging tumour physiology.
Magnetic resonance (MR) techniques have the unique ability to measure in vivo the biochemical content of living tissue in the body in a dynamic, non-invasive and non-destructive manner. MR also permits serial investigations of steady-state tumour physiology and biochemistry, as well as the response of a tumour to treatment. Magnetic resonance imaging (MRI), Magnetic resonance spectroscopy (MRS) and a mixture of the two techniques (spectroscopic imaging) allow some physiological parameters, for example pH, to be 'imaged'. Using these methods, information on tissue bioenergetics and phospolipid membrane turnover, pH, hypoxia, oxygenation, and various aspects of vascularity including blood flow, angiogenesis, permeability and vascular volume can be obtained. In addition, MRS methods can be used for monitoring anticancer drugs (e.g. 5FU, ifosfamide) and their metabolites at their sites of action. The role of these state-of-the-art MR methods in imaging tumour physiology and their potential role in the clinic are discussed.
Stubbs
M
M
Cancer Research Campaign Biomedical Magnetic Resonance Research Group, Department of Biochemistry, St. George's Hospital Medical School, London, UK. mstubbs@sghms.ac.uk
D015687:Cell Hypoxia; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000098:blood supply / Q000503:physiopathology* / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000503:physiopathology