Cytokine therapy: a natural alternative for disease control.
Disease control in food production animals is normally mediated through the use of vaccines, chemicals and antibiotics. However, the extensive use of antibiotics and chemicals in livestock has resulted in environmental and human health concerns, particularly with regard to the emergence of drug-resistant bacteria in the food chain. In fact, the World Health Organisation (WHO) has now urged meat producers to use environmentally-friendly alternative methods to control disease. Cytokines, as natural mediators of the immune response, offer exciting alternatives to conventional therapeutics. The utilisation of cytokines is becoming more feasible with the recent cloning of a number of cytokine genes. Since the chicken's immune system is similar to that of mammals, they offer an attractive model system with which to study the effectiveness of cytokine therapy in the control of disease in intensive livestock. In this report we will review our recent studies on the therapeutic potential of chicken interferon gamma (ChIFN-gamma) as a vaccine adjuvant and a growth promoter.
Lowenthal
J W
JW
CSIRO Division of Animal Health, Australian Animal Health Laboratory, Geelong, Victoria.
O'Neil
T E
TE
David
A
A
Strom
G
G
Andrew
M E
ME
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D002645:Chickens / Q000276:immunology*; D003048:Coccidiosis / Q000517:prevention & control / Q000662:veterinary; D004539:Eimeria / Q000276:immunology; D007371:Interferon-gamma / Q000008:administration & dosage / Q000276:immunology*; D018448:Models, Immunological; D011201:Poultry Diseases / Q000469:parasitology / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology*; D015430:Weight Gain
D000276:Adjuvants, Immunologic; D016052:Protozoan Vaccines; D007371:Interferon-gamma