title: An antioxidant lignan and other constituents from the root bark of Hibiscus syriacus.
abstract: A new lignan named as hibiscuside, (+)-pinoresinol 4-O-[beta-glucopyranosyl (1--->2)-alpha-rhamnoside] (1), and a known lignan, syringaresinol (2) were isolated from the root bark of Hibiscus syriacus together with two feruloyltyramines (3,4) and three known isoflavonoids (5,6,7). The structures of these compounds have been established on the basis of their NMR, mass UV spectra. Among these phenolic compounds, 6"-O-acetyldaidzin (5), 6"-O-acetylgenistin (6), and 3-hydroxydaidzein (7) with IC(50) values of 8.2, 10.6, and 4.1 microM, respectively, significantly inhibited lipid peroxidation in rat liver microsomes. Hibiscuside (1), E- and Z-N-feruloyl tyramines (3,4) exhibited moderate antioxidant activity.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Y S
authors.initials: YS
authors.lastname: Yun
authors.forename: I K
authors.initials: IK
authors.lastname: Lee
authors.forename: I J
authors.initials: IJ
authors.lastname: Ryoo
authors.forename: B S
authors.initials: BS
authors.lastname: Yun
authors.forename: I D
authors.initials: ID
authors.lastname: Yoo
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004187:Disaccharides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D006027:Glycosides; D066298:In Vitro Techniques; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D019660:Malvaceae / Q000737:chemistry*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats
chemical_list: D000975:Antioxidants; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004187:Disaccharides; D005663:Furans; D006027:Glycosides; D017705:Lignans; C401934:hibiscuside; C042192:syringaresinol