title: Lack of correlation between left ventricular mass and diameter of left coronary artery main trunk in hypertensive patients.
abstract: The study was designed to evaluate whether the increase in left ventricular (LV) mass in essential hypertensives (H) is associated with a proportional increase in diameter of the left coronary artery (LCA) trunk. Twenty-six hypertensives, 14 with left ventricular hypertrophy (LVH) (left ventricular mass index [LVMI] > or =134 g/m2 in men and > or =110 g/m2 in women) and 12 without LVH, and 10 normotensive controls (C) underwent clinical laboratory and echocardiographic transthoracic examination. LV dimensions were measured according to the Penn convention and LV mass calculated by the formula of Devereux. The LCA main trunk was visualized by two-dimension short axis view at the level of the great vessels section, and the diameter measured as intima-intima distance at end-diastole. Hypertensives with and without LVH and C had similar age, sex, and body surface area distribution. LVMI was, by definition, significantly higher in H with LVH than in H without LVH and in C (144+/-21, 113+/-13, and 98+/-10 g/m2, P<.01), whereas the diameter of the LCA trunk was similar in all groups (0.48+/-0.1, 0.48, and 0.46 cm, respectively). There was no significant correlation between LVMI and LCA diameter in H (r = 0.21, P = not significant). The diameter of LCA trunk was significantly correlated only with BSA (r = 0.5, P<.01), LV end-systolic and end-diastolic diameters (r = 0.5 and r = 0.4, P<.05). Our data suggest that in H the increase in LVM is not associated with a concomitant increase of epicardial coronary artery diameter, and this finding may account in part for the impairment of coronary blood flow reserve in LVH.
authors.affiliation: Istituto di Clinica Medica Generale e Terapia Medica and Centro Fisiologia Clinica e Ipertensione, Università di Milano and Ospedale Maggiore, IRCCS, Milano, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Cuspidi
authors.forename: L
authors.initials: L
authors.lastname: Lonati
authors.forename: L
authors.initials: L
authors.lastname: Sampieri
authors.forename: L
authors.initials: L
authors.lastname: Valagussa
authors.forename: I
authors.initials: I
authors.lastname: Michev
authors.forename: G
authors.initials: G
authors.lastname: Leonetti
authors.forename: A
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D015150:Echocardiography, Doppler; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000473:pathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D011379:Prognosis