Elevated adrenomedullin in the vitreous of patients with proliferative vitreoretinopathy.
OBJECTIVE
To explore the possible involvement of adrenomedullin in the pathophysiology of proliferative vitreoretinopathy.


METHODS
The radioimmunoassay technique was used to determine immunoreactive adrenomedullin concentrations in the vitreous fluid from 41 eyes of 41 patients undergoing vitrectomy for a variety of retinal conditions, including proliferative vitreoretinopathy, proliferative diabetic retinopathy, age-related macular degeneration, and macular hole.


RESULTS
Immunoreactive adrenomedullin levels in the vitreous of patients with proliferative vitreoretinopathy were significantly higher than those of patients with proliferative diabetic retinopathy (P < .005), age-related macular degeneration (P < .001), and macular hole (P < .0001).


CONCLUSIONS
Adrenomedullin may be involved in the pathophysiology of proliferative vitreoretinopathy.
Udono
T
T
Department of Molecular Biology and Applied Physiology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
Takahashi
K
K
Takano
S
S
Shibahara
S
S
Tamai
M
M
D053607:Adrenomedullin; D003930:Diabetic Retinopathy / Q000378:metabolism / Q000601:surgery; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000378:metabolism / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*; D011863:Radioimmunoassay; D012167:Retinal Perforations / Q000378:metabolism / Q000601:surgery; D014665:Vasodilator Agents / Q000378:metabolism*; D014821:Vitrectomy; D018630:Vitreoretinopathy, Proliferative / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery; D014822:Vitreous Body / Q000378:metabolism*
D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin