Anti-diarrhoeal evaluation of Clerodendrum phlomidis Linn. leaf extract in rats.
A study was undertaken to evaluate the effect of methanolic extract of leaves of Clerodendrum phlomidis Linn. (MECP) (Family: Verbenaceae) for its anti-diarrhoeal potential against several experimental models of diarrhoea in Wistar albino rats. MECP showed significant inhibitory activity against castor oil induced diarrhoea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastrointestinal motility in charcoal meal test in rats. The results obtained establish the efficacy and substantiated the folklore claim as an anti-diarrhoeal agent.
Rani
S
S
Department of Pharmaceutical Chemistry, Maharaji College of Pharmacy, Besant Nagar, Chennai, India.
Ahamed
N
N
Rajaram
S
S
Saluja
R
R
Thenmozhi
S
S
Murugesan
T
T
D000818:Animals; D000930:Antidiarrheals / Q000627:therapeutic use*; D002368:Castor Oil / Q000633:toxicity; D003967:Diarrhea / Q000188:drug therapy*; D015232:Dinoprostone / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D008519:Medicine, Traditional; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility
D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil; D015232:Dinoprostone; D000432:Methanol