Comparative genomics and evolutionary biology.
Data of large-scale DNA sequencing are relevant to some of the most fundamental issues in evolutionary biology: suboptimality, homology, hierarchy, ancestry, novelties, the role of natural selection, and the relative importance of directional versus stabilizing selection. Already, these data provided the best available evidence for some evolutionary phenomena, and in several cases led to refinement of old concepts. Still, the Darwinian evolutionary paradigm will successfully accommodate comparative genomics.
Kondrashov
A S
AS
National Center for Biotechnology Information, National Institutes of Health, Bethesda, 20894, USA. Kondrashov@ncbi.nlm.nih.gov
D000818:Animals; D019143:Evolution, Molecular; D005787:Gene Frequency; D020131:Genes, Duplicate / Q000235:genetics; D016678:Genome; D006801:Humans; D009154:Mutation / Q000235:genetics; D010802:Phylogeny; D012641:Selection, Genetic; D017385:Sequence Homology