title: [Management of cholestasis in pregnancy].
abstract: METHODS
  Pruritus in a pregnant women with healthy skin is suggestive of gravid cholestasis. The diagnosis can only be retained after ruling out viral or drug-induced hepatitis or gallbladder disease. The best markers are maternal serum transaminase and bile acid levels.
  The perinatal consequences of gravid cholestasis are minimal if reasonable premature delivery is accepted.
  Ursodesoxycholic acid is an interesting therapeutic option if pruritus is untolerable or if the diagnosis is made early in pregnancy. Injection of vitamin K prevents coagulation disorders.
authors.affiliation: Hôpital Charles Nicolle, Rouer.
authors.forename: L
authors.initials: L
authors.lastname: Marpeau
authors.forename: E
authors.initials: E
authors.lastname: Verspyck
authors.forename: G
authors.initials: G
authors.lastname: Descargues
mesh_terms: D002779:Cholestasis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology*; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D014580:Ursodeoxycholic Acid