Adjunctive treatment of congenital pigmented nevi with phenol chemical peel.
The purpose of this study was a retrospective evaluation of the treatment of congenital pigmented nevi using the phenol chemical peel technique. Patients were treated with standard Baker formula in the operating room under general anesthesia or intravenous sedation with continuous electrocardiogram monitoring. A total of 20 patients were reviewed (13 girls and 7 boys, mean age 3.8 years). Eight patients had nevi located on the face, five patients had trunk lesions, and three patients had lesions on the thighs. Two patients had nevi located on both the face and the trunk, and two patients had involvement of the face, trunk, and thigh. Three of the above patients had the classic "bathing trunk" distribution of the nevi. A test area was peeled in four patients, and in five patients preoperative biopsies were performed to rule out malignancy before initiation of therapy. An average of 2.6 treatments were performed per patient. Two patients had adjunctive dermabrasion to increase the depth of peel and to contour surface irregularities. The length of follow-up ranged from 6 to 84 months with a mean of 28 months. Healing of the wounds occurred within 2 to 3 weeks postoperatively. Seventy-five percent of patients had satisfactory cosmetic improvement in the appearance of the lesions following treatment. Four patients had recurrence of the pigmentation after an initial lightening response, three of whom had their nevi subsequently excised. There was no incidence of hypertrophic scarring or cardiac and/or renal complications. There was one death from complications of leptomeningeal melanocytosis. Chemical peeling of congenital pigmented nevi is an acceptable alternative method of therapy for those lesions that are too large for excision and primary closure or for lesions in which excision would result in unacceptable scars in areas such as the face.
Hopkins
J D
JD
Institute for Craniofacial and Reconstructive Surgery, Southfield, Mich., USA.
Smith
A W
AW
Jackson
I T
IT
D000293:Adolescent; D002615:Chemexfoliation; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005153:Facial Neoplasms / Q000151:congenital / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D009508:Nevus, Pigmented / Q000151:congenital* / Q000628:therapy; D019800:Phenol; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000151:congenital* / Q000628:therapy; D016038:Skin Transplantation; D016896:Treatment Outcome
D019800:Phenol