Roles of lipoarabinomannan in the pathogenesis of tuberculosis.
Tuberculosis is a worldwide public health threat caused by Mycobacterium tuberculosis. All mycobacteria express a unique cell envelope glycolipid, lipoarabinomannan, which can be released at sites of infection. Lipoarabinomannan is a potential virulence factor which can bind to leukocytes and modulate immune responses. Here, we provide an overview of the interactions of mycobacteria and lipoarabinomannan with immune cells.
Strohmeier
G R
GR
Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA.
Fenton
M J
MJ
D000818:Animals; D018925:Chemokines / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D008070:Lipopolysaccharides / Q000737:chemistry / Q000378:metabolism*; D008262:Macrophage Activation; D016676:Macrophages, Alveolar / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000378:metabolism / Q000472:pathogenicity*; D010587:Phagocytosis; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology*; D014774:Virulence
D018925:Chemokines; D008070:Lipopolysaccharides; C050016:lipoarabinomannan