title: Localized reversible frameshift mutation in the flhA gene confers phase variability to flagellin gene expression in Campylobacter coli.
abstract: Phase variation of flagellin gene expression in Campylobacter coli UA585 was correlated with high-frequency, reversible insertion and deletion frameshift mutations in a short homopolymeric tract of thymine residues located in the N-terminal coding region of the flhA gene. Mutation-based phase variation in flhA may generate functional diversity in the host and environment.
authors.affiliation: School of Biological Sciences, University of Surrey, Guildford, GU2 5XH, United Kingdom. s.park@surrey.ac.uk
authors.forename: S F
authors.initials: SF
authors.lastname: Park
authors.forename: D
authors.initials: D
authors.lastname: Purdy
authors.forename: S
authors.initials: S
authors.lastname: Leach
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D017000:Campylobacter coli / Q000235:genetics*; D005408:Flagellin / Q000235:genetics* / Q000378:metabolism; D016368:Frameshift Mutation; D015964:Gene Expression Regulation, Bacterial; D005816:Genetic Complementation Test; D014644:Genetic Variation; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C080688:FlhA protein, Bacteria; D008565:Membrane Proteins; D005408:Flagellin; C067138:flaA protein, bacteria; C416532:flaB flagellin