Aromatic carboxylic acids as farnesyl surrogates in farnesylpyrophosphate-based farnesyltransferase inhibitors.
With the help of easily obtainable N-acylaspartic acids, the 4-phenylcinnamoyl and the 4-benzyloxycinnamoyl moiety were identified as structurally simple, readily available farnesyl surrogates, yielding more potent inhibitors of farnesyltransferase than the literature known N-farnesoylaspartic acid.
Schlitzer
M
M
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Germany.
Sattler
I
I
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D001224:Aspartic Acid / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D020128:Inhibitory Concentration 50
D004791:Enzyme Inhibitors; D001224:Aspartic Acid; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase