title: Physicochemical characterization of YJA20379-8, a new proton pump inhibitor.
abstract: The physicochemical properties of the potent reversible proton pump inhibitor YJA20379-8, 3-butyryl-4-[(R)-1-methylbenzylamino]-8-ethoxy-1,7-naphthyridine, were studied. YJA20379-8 is essentially nonhygroscopic pale yellowish crystalline powder. It is practically insoluble in water, and its lipid solubility is high. The pH solubility profile exhibits an L-shaped curve, indicating YJA20379-8 is a basic substance having a soluble ionized form in acidic conditions. This is consistent with the result of an experiment to determine pKa. The solid-state stability study shows that YJA20379-8 is stable at various temperatures and humidities, but is decomposed by light.
authors.affiliation: Department of Formulation, Yungjin Pharmaceutical Company, Hwasung-kun, Kyunggi-do, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: C
authors.initials: C
authors.lastname: Park
authors.forename: M
authors.initials: M
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Cha
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Chung
mesh_terms: D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D009287:Naphthyridines / Q000737:chemistry* / Q000494:pharmacology*; D054328:Proton Pump Inhibitors; D012995:Solubility
chemical_list: C114511:3-butyryl-4-(5R-methylbenzylamino)-8-ethoxy-1,7-naphthyridine; D000897:Anti-Ulcer Agents; D009287:Naphthyridines; D054328:Proton Pump Inhibitors