Idiotypic regulation in Schistosomiasis mansoni.
The role of anti-idiotype Ab2 in regulation of the immune response in schistosomiasis was studied. Positive Ab2 could be detected among the newborns of infected mothers and experimentally S. mansoni- infected mice. Negative anti-idiotypic antibodies were observed among children above 3 years and control mice. Increasing levels of anti-idiotypic antibodies were detected among S. mansoni infected children and adults. Higher mean anti-idiotype A2 levels were found among patients with hepatosplenomegaly than those with intestinal manifestations. The kinetics of anti-idiotype Ab2 among the S. mansoni- infected mice started from the end of the first week after infection up to 8 weeks. It was continuous, but with undulating levels. Moreover, the anti-idiotype antibody was able to stimulate lymphocyte proliferation at 8 weeks post infection.
Hassan
M M
MM
Department of Parasitology, Faculty of Medicine, Zagazig University, Egypt.
Mostafa
N
N
Sultan
M
M
Gaafar
M
M
Mostafa
N
N
D000328:Adult; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood / Q000276:immunology*; D000909:Antibodies, Helminth / Q000097:blood / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D012550:Schistosoma mansoni / Q000276:immunology*; D012555:Schistosomiasis mansoni / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000909:Antibodies, Helminth