title: U-50,488 and the kappa receptor. Part II: 1991-1998.
abstract: This review, Part II, follows an earlier article, Part I, published in volume 52 of this series. Part II is a discussion of centrally and peripherally acting kappa agonists which can be considered analogs of U-50,488. Included also are three classes of kappa agonists which fall outside of the scope of the general structure of U-50,488. These are benzodiazepines, phenothiazines and diazobicyclonanones. The discussion also covers other pertinent topics including labelled ligands and sigma receptor.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556-5670, USA.
authors.forename: J
authors.initials: J
authors.lastname: Szmuszkovicz
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D017473:Receptors, Opioid, kappa / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000737:chemistry
chemical_list: D017473:Receptors, Opioid, kappa; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer