title: A note on the relevance of human population genetic variation and molecular epidemiology to assessing radiation health risk for space travellers.
abstract: We discuss the relevance to space medicine of studies concerning human genetic variation and consequent variable disease susceptibility or sensitivity between individuals. The size of astronaut and cosmonaut populations is both presently and cumulatively small, and despite the launch of the International Space Station, unlikely to increase by orders of magnitude within the foreseeable future. In addition, astronauts-cosmonauts constitute unrepresentative samples of their national populations. While the context of exposure for the astronaut-cosmonaut group is one unlikely to be replicated elsewhere than in space, aspects of specific exposures may be simulated by events such as occupational radiation exposure or radiation therapy. Hence, population-based studies of genetic susceptibility or sensitivity to disease, especially where it is precipitated by events that may simulate consequences of the space environment, likely will prove of value in assessing long-term health risks.
authors.affiliation: Centre for Environmental Health, and the Department of Biology, University of Victoria, Victoria, British Columbia, Canada. brackley@uvic.ca
authors.forename: M E
authors.initials: ME
authors.lastname: Brackley
authors.forename: J
authors.initials: J
authors.lastname: Curry
authors.forename: B W
authors.initials: BW
authors.lastname: Glickman
mesh_terms: D018480:Astronauts; D004247:DNA / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D009784:Occupational Diseases / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D011832:Radiation Injuries / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D011836:Radiation Tolerance / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors; D013026:Space Flight
chemical_list: D004247:DNA