Association analysis of the 5-HT6 receptor polymorphism C267T in Alzheimer's disease.
Serotonergic dysfunction has been implicated in the pathogenesis of Alzheimer's disease (AD). This association study explores whether the serotonin 6 receptor (5-HT6) polymorphism (C267T) is a susceptibility factor for AD. Statistical analysis showed a significant difference in the genotype and gene frequencies between the AD group and the normal controls (P = 0.006; and P = 0.023, respectively). These findings indicate that the 267C allele of the 5-HT6 gene is a risk factor for AD.
Tsai
S J
SJ
Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, ROC.
Liu
H C
HC
Liu
T Y
TY
Wang
Y C
YC
Hong
C J
CJ
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011985:Receptors, Serotonin / Q000235:genetics*
D011985:Receptors, Serotonin; C097216:serotonin 6 receptor