Post-coital antifertility activity of Acalypha indica L.
Four successive solvent extracts of the whole plant Acalypha indica L. (Euphorbiaceae) were tested for post-coital antifertility activity in female albino rats. Of these, the petroleum ether and ethanol extracts were found to be most effective in causing significant anti-implantation activity. The antifertility activity was reversible on withdrawal of the treatment of the extracts. Both the extracts at 600 mg/kg body weight showed estrogenic activity. Histological studies of the uterus were carried out to confirm this estrogenic activity.
Hiremath
S P
SP
Department of Chemistry, Gulbarga University, India.
Rudresh
K
K
Badami
S
S
Patil
S B
SB
Patil
S R
SR
D000284:Administration, Oral; D000818:Animals; D003270:Contraceptive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003307:Copulation; D004305:Dose-Response Relationship, Drug; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D005260:Female; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D003270:Contraceptive Agents; D020847:Estrogen Receptor Modulators; D004967:Estrogens; D010936:Plant Extracts