Lessons from gene modified mice.
Chemokines have been implicated in leukocyte trafficking, angiogenesis, immunoregulation and development. Understanding these and other chemokine functions in vivo is an enormously complex task, but one that is being facilitated by the application of powerful genetic techniques. Here I will summarise the results of a variety of genetic studies in mice and discuss how they have helped us to understand the biological role of chemokines and their receptors.
Lira
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Department of Immunology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
D000818:Animals; D018925:Chemokines / Q000737:chemistry / Q000235:genetics* / Q000276:immunology*; D004195:Disease Models, Animal; D005818:Genetic Engineering; D005821:Genetic Techniques; D007121:Immunocompetence / Q000276:immunology; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic / Q000235:genetics* / Q000276:immunology*; D009389:Neovascularization, Pathologic / Q000276:immunology
D018925:Chemokines