title: Distribution and antigenicity of fibronectin binding proteins (SfbI and SfbII) of Streptococcus pyogenes clinical isolates from the northern territory, Australia.
abstract: Fibronectin binding proteins play an important role in the adherence and invasion of group A streptococci (GAS). Genotypically distinct GAS isolates were screened for the presence and expression of two streptococcal fibronectin binding protein genes, sfbI and sfbII. Of the tested strains, 64 and 36% were shown to harbor and express the sfbI and sfbII genes, respectively. All sfbII-positive strains tested were also positive for sfbI, but only 28% of the sfbII-negative strains were positive for sfbI. High levels of immunoglobulin G antibodies to both SfbI and SfbII were found in sera from 80 subjects with defined streptococcal infections.
authors.affiliation: Menzies School of Health Research, Casuarina, Australia.
authors.forename: A M
authors.initials: AM
authors.lastname: Goodfellow
authors.forename: M
authors.initials: M
authors.lastname: Hibble
authors.forename: S R
authors.initials: SR
authors.lastname: Talay
authors.forename: B
authors.initials: B
authors.lastname: Kreikemeyer
authors.forename: B J
authors.initials: BJ
authors.lastname: Currie
authors.forename: K S
authors.initials: KS
authors.lastname: Sriprakash
authors.forename: G S
authors.initials: GS
authors.lastname: Chhatwal
mesh_terms: D018829:Adhesins, Bacterial; D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005353:Fibronectins; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D008875:Middle Aged; D015876:Northern Territory; D013290:Streptococcal Infections / Q000097:blood*; D013297:Streptococcus pyogenes / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; D005353:Fibronectins; D007074:Immunoglobulin G; D008565:Membrane Proteins; C078635:fibronectin-binding proteins, bacterial