Lipoproteins take their toll on the host.
A family of mammalian Toll-like receptors (TLRs) has a critical role in the recognition of microbial infection. Recent evidence suggests that bacterial lipoproteins - major components of bacterial cell walls - are recognized by a member of the human TLR family.
Janeway
C A
CA
Section of Immunobiology, Yale University School of Medicine, P.O. Box 208011, New Haven, 06520-8011, USA.
Medzhitov
R
R
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology*; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D008074:Lipoproteins / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology* / Q000378:metabolism; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008074:Lipoproteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors