A patient with genetic deletion of glutathione-S-transferase T1 and M1 who developed non-small-cell lung cancer and myelodysplastic syndromes.
Glutathione S-transferase (GST) M1 polymorphism is a marker for susceptibility to smoking-related neoplasms, such as lung and bladder cancer. Recently, a genetic deletion of GSTT1, an isoenzyme of GST, has been reported to be associated with myelodysplastic syndromes (MDS). A 59-year-old man with a long-term smoking habit was treated successfully for non-small-cell lung cancer. Four years after the surgical removal of his lung cancer, he developed MDS and died. Using a polymerase chain reaction-based genotyping method, he was found to have a deletion of both the GSTM1 and GSTT1 genes. Screening for the deletion of the GSTM1 and GSTT1 genes may be useful for assessing individual genetic susceptibility to smoking-related lung cancer and MDS.
Arai
Y
Y
Department of Geriatric Medicine, Keio University School of Medicine, Tokyo, Japan. yasumich@tka.att.ne.jp
Hirose
N
N
Yamamura
K
K
Nagai
M
M
Jang
H
H
Hattori
Y
Y
Ikeda
Y
Y
D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001853:Bone Marrow / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000235:genetics*; D017931:DNA Primers; D017353:Gene Deletion; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012907:Smoking / Q000009:adverse effects
D014408:Biomarkers, Tumor; D017931:DNA Primers; D005982:Glutathione Transferase