Gastroprotective effect from Calophyllum brasiliense Camb. bark on experimental gastric lesions in rats and mice.
In order to establish the pharmacological basis for the ethnomedicinal use of stem bark extracts of Calophyllum brasiliense Camb. in gastrointestinal affections, this study examined the effects of a dichloromethane fraction (DCMF), obtained from the hexane extract of bark, on ethanol, indomethacin and hypothermic restraint stress-induced gastric lesions in mice and rats, respectively. Oral administration of DCMF at doses ranging from 12.5-250 mg/kg significantly inhibited the development of gastric lesions in all the three test models. It caused significant decreases of the pyloric-ligation and bethanechol-stimulated gastric secretion, and also the free and total acidities. Besides, DCMF offered protection against ethanol-induced depletion of stomach wall mucus and reduction in nonprotein sulfhydryl concentration. The results indicate that DCMF from C. brasiliense possesses antisecretory, antiulcer and cytoprotective properties.
Sartori
N T
NT
Department of Basic Sciences in Health FCM/ISC, Federal University of Mato Grosso, Campus Universitario, Cuiabá, MT, Brazil.
Canepelle
D
D
de Sousa
P T
PT
Martins
D T
DT
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D007035:Hypothermia / Q000150:complications; D007213:Indomethacin / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008297:Male; D051379:Mice; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D007213:Indomethacin