title: On the natural history of trigeminal neuralgia.
abstract: OBJECTIVE
  Trigeminal neuralgia is usually considered a separate entity from atypical trigeminal neuralgia. The exact relationship among these two and several other syndromes of facial pain remains unknown. There is no long-term prospective study of the natural history of trigeminal neuralgia nor any explanation for the existence of different, albeit somewhat similar, facial pain syndromes.
  On the basis of our clinical experience, we propose a theory that may explain different facial pain syndromes as sequential stages of the same disease process. Typical trigeminal neuralgia caused by microvascular compression of the trigeminal nerve root in the posterior fossa may become transformed over time into atypical trigeminal neuralgia, if left untreated. This transformation involves change in the character of pain and development of sensory impairment. Two representative cases are presented to support this theory.
  
  
  CONCLUSIONS
  If the theory of progressive change in character of pain and degree of sensory impairment in the course of otherwise typical trigeminal neuralgia is correct, trigeminal neuralgia, atypical neuralgia, and trigeminal neuropathic pain may represent different degrees of injury to the trigeminal nerve, therefore comprising a continuous spectrum rather than discrete diagnoses.
authors.affiliation: Department of Neurological Surgery, Oregon Health Sciences University, Portland 97201-3098, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Burchiel
authors.forename: K V
authors.initials: KV
authors.lastname: Slavin
mesh_terms: D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D014277:Trigeminal Neuralgia / Q000150:complications* / Q000175:diagnosis*