title: CD8+ T lymphocytes against mycobacterium tuberculosis.
abstract: Tuberculosis (TB) is again a global health problem. Identification and characterization of the correlates of protective immunity against TB is critical for the rationale design of novel TB vaccines. There is accumulating data that CD8+ T lymphocytes are involved in the immune response against mycobacteria. Here the current state of the art is reviewed with respect to phenotype, specificity and effector mechanisms of mycobacteria-specific CD8+ T lymphocytes. In addition, the first listing is presented of mycobacteria-derived CD8+ cytotoxic T lymphocyte (CTL) epitopes containing sequences published up to the end of 1998.
authors.affiliation: Tuberculosis Research Programme, Medical Research Council Laboratories, Banjul, Gambia, West Africa.
authors.forename: M R
authors.initials: MR
authors.lastname: Klein
authors.forename: K P
authors.initials: KP
authors.lastname: McAdam
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology; D001500:BCG Vaccine / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005544:Forecasting; D014943:Global Health; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014376:Tuberculosis / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology; D019444:Vaccines, DNA / Q000276:immunology; D014614:Vaccines, Synthetic / Q000276:immunology; D001613:beta 2-Microglobulin / Q000172:deficiency / Q000235:genetics
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine; D001428:Bacterial Vaccines; D006680:HLA Antigens; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic; D001613:beta 2-Microglobulin