title: Efficacy of fluocinolone acetonide gel in the treatment of oral lichen planus.
abstract: OBJECTIVE
  The purpose of this study was to compare the efficacy of fluocinolone acetonide gel 0.1% in 2 base forms (numbers 1 and 2) with fluocinolone acetonide in an oral base 0.1%.
  
  
  METHODS
  Forty-eight patients with histologically confirmed oral lichen planus were enrolled in the study. Lesions were scored ranging from 0 (no lesion) to 5 (large erosion) according to the severity. Patients were randomly given fluocinolone acetonide in an oral base, fluocinolone acetonide gel no. 1 or no. 2. They were asked to apply the medication on dried lesions 4 times a day. The lesions were evaluated after 2 and 4 weeks of treatment. The severity scores were analyzed by the Kruskal-Wallis k-sample test.
  
  
  RESULTS
  Patients who received fluocinolone acetonide in an oral base and those who received fluocinolone acetonide gel no. 1 and no. 2 improved from the average score of 3.0, 3.0, and 2.9 to 1.5, 1.5, and 1.6, respectively. There were no statistically significant differences in score changes noted in the 3 groups. The results indicate that fluocinolone acetonide gel no. 1 and no. 2 and fluocinolone acetonide in an oral base provide similar efficacy in the treatment of oral lichen planus.
  
  
  CONCLUSIONS
  Fluocinolone acetonide gel 0.1% is a safe and effective alternative therapy to fluocinolone acetonide in an oral base 0.1% in the treatment of oral lichen planus.
authors.affiliation: Department of Oral Medicine, Mahidol University, Bangkok, Thailand.
authors.forename: W
authors.initials: W
authors.lastname: Buajeeb
authors.forename: C
authors.initials: C
authors.lastname: Pobrurksa
authors.forename: P
authors.initials: P
authors.lastname: Kraivaphan
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage*; D005782:Gels; D005938:Glucocorticoids; D006801:Humans; D017676:Lichen Planus, Oral / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement / Q000706:statistics & numerical data; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D000893:Anti-Inflammatory Agents; D005782:Gels; D005938:Glucocorticoids; D005446:Fluocinolone Acetonide