title: Opposite changes in phosphoinositide-specific phospholipase C immunoreactivity in the left prefrontal and superior temporal cortex of patients with chronic schizophrenia.
abstract: BACKGROUND
  Abnormalities in types of neurotransmitter signaling that are coupled with phosphoinositide-specific phospholipase C (PLC) have previously been reported in brains from patients with schizophrenia. PLC, a main component of this pathway, may be affected in schizophrenia.
  
  
  METHODS
  We immunoquantified PLC beta 1, gamma 1 and delta 1 in the left prefrontal cortex and superior temporal cortex, nucleus accumbens and amygdala, and in the right superior temporal cortex of postmortem brains obtained from a total of 19 patients with schizophrenia and a total of 27 controls.
  
  
  RESULTS
  PLC beta 1 immunoreactivities were increased in the particulate fraction from the prefrontal cortex (by 64%), although they were decreased in the particulate fraction from the left superior temporal cortex (by 28%), as compared with the values in controls. There was no difference in PLC beta 1 immunoreactivities in the nucleus accumbens, the amygdala or the right superior temporal cortex between schizophrenic patients and controls. PLC gamma 1 and delta 1 immunoreactivities did not differ between the two groups in any of the regions studied.
  
  
  CONCLUSIONS
  Changes in PLC beta 1 immunoreactivities in the prefrontal and superior temporal cortex of patients with schizophrenia may reflect abnormalities in neurotransmissions via receptors that are coupled with the Gq alpha-PLC beta 1 cascade.
authors.affiliation: Department of Psychiatry and Neurology, Kobe University School of Medicine, Japan.
authors.forename: X H
authors.initials: XH
authors.lastname: Lin
authors.forename: N
authors.initials: N
authors.lastname: Kitamura
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
authors.forename: O
authors.initials: O
authors.lastname: Shirakawa
authors.forename: K
authors.initials: K
authors.lastname: Maeda
mesh_terms: D000679:Amygdala / Q000201:enzymology; D015153:Blotting, Western; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009714:Nucleus Accumbens / Q000201:enzymology; D010716:Phosphatidylinositols / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000201:enzymology*; D012559:Schizophrenia / Q000201:enzymology*; D013702:Temporal Lobe / Q000201:enzymology*; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D010716:Phosphatidylinositols; D010738:Type C Phospholipases