title: Evaluation of p-nitrophenyl substituted semicarbazones for anticonvulsant properties.
abstract: A series of p-nitrophenyl substituted semicarbazones has been synthesised and their anticonvulsant activity was screened against MES, scPTZ and scSTY. 4(4'-Nitrophenyl)-o-nitrobenzaldehyde semicarbazone has been found to be the most active in all these tests. The studies revealed that a primary amino function is not essential for anticonvulsant activity in the semicarbazone series of compounds. Presumably these compounds could further act on glycine receptors.
authors.affiliation: Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: I
authors.initials: I
authors.lastname: Ponnilavarasan
authors.forename: A
authors.initials: A
authors.lastname: Pandey
authors.forename: R
authors.initials: R
authors.lastname: Lakhan
authors.forename: J P
authors.initials: JP
authors.lastname: Stables
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003292:Convulsants; D004597:Electroshock; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010433:Pentylenetetrazole; D004856:Postural Balance / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013331:Strychnine
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D012664:Semicarbazones; D013331:Strychnine; D010433:Pentylenetetrazole