Survival following fulminant hepatic failure from fluconazole induced hepatitis.
We present a case of recovery from fulminant hepatic failure secondary to high serum levels of fluconazole precipitated by amphotericin B induced renal dysfunction. Fluconazole dose adjustment or alternative antifungal treatment should be considered in patients with impaired renal function.
Crerar-Gilbert
A
A
Intensive Care Facility, Royal Brisbane Hospital, Queensland.
Boots
R
R
Fraenkel
D
D
MacDonald
G A
GA
D000666:Amphotericin B / Q000009:adverse effects / Q000627:therapeutic use; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000209:etiology; D003453:Cryptococcosis / Q000188:drug therapy; D005260:Female; D015725:Fluconazole / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000187:drug effects; D017093:Liver Failure / Q000209:etiology* / Q000628:therapy; D008875:Middle Aged
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole