Potential carcinogenicity of the synthetic 1,3,6-triazine (6-azapyrimidine) nucleic acid analogues determined by DC polarography. II. Nucleosides of 6-azauracil.
The polarographic reduction of six synthetic 1,3,6-triazine (6-aza) nucleosides with 6-azauracil as the nucleoside base in the strictly anhydrous solutions was studied in the absence and presence of alpha-lipoic acid. The values of the half-wave potentials E1/2 and the parameter of potential carcinogenicity tg alpha were compared for six nucleosides of 6-azauracil and two nucleosides of 4-thio-6-azauracil. The current value of the first diffuse polarographic wave or a new diffuse polarographic wave belonging to the nucleoside-alpha-lipoic acid complex increased with the increase of the alpha-lipoic acid concentration for the all compounds only marginally. Although this diffuse current increase was linear and dependent on the alpha-lipoic acid concentration in anhydrous solutions, the determined index tg alpha values ranged between 0.027 and 0.114. This is an indication of a very low potential carcinogenicity of the all nucleoside analogues investigated.
Novotný
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L
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University.
Vachálková
A
A
Pískala
A
A
D001380:Azauridine / Q000737:chemistry* / Q000633:toxicity; D002273:Carcinogens / Q000737:chemistry* / Q000633:toxicity*; D011048:Polarography / Q000379:methods; D013329:Structure-Activity Relationship; D008063:Thioctic Acid; D014227:Triazines / Q000737:chemistry* / Q000633:toxicity; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity
D002273:Carcinogens; D014227:Triazines; D014498:Uracil; D008063:Thioctic Acid; D001380:Azauridine; C100248:azauracil