title: Simvastatin-induced lupus-like syndrome.
abstract: The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are widely used as cholesterol lowering agents that have an acceptable safety profile. As a group, this class of drugs has been associated with few immunologic reactions. Simvastatin (Zocor) has been linked to three cases of drug-induced lupus-like syndrome. We report the case of an additional patient who developed pleurisy and arthralgia after he started taking this low-density lipoprotein and cholesterol-lowering agent.
authors.affiliation: Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0622, USA.
authors.forename: A
authors.initials: A
authors.lastname: Ahmad
authors.forename: M T
authors.initials: MT
authors.lastname: Fletcher
authors.forename: T M
authors.initials: TM
authors.lastname: Roy
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced; D006801:Humans; D008177:Lupus Vulgaris / Q000139:chemically induced*; D008297:Male; D010998:Pleurisy / Q000139:chemically induced; D019821:Simvastatin / Q000009:adverse effects*
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin