Benzydamine hydrochloride oral rinses in management of burning mouth syndrome. A clinical trial.
OBJECTIVE
The purpose of this study was to evaluate the efficacy of the topical use of benzydamine hydrochloride 0.15% oral mouthwashes in the control of burning mouth syndrome symptoms.


METHODS
In this double-blind, randomized, longitudinal investigation, each of 30 patients with burning mouth syndrome was assigned to one of 3 management modalities. Those in group A received an oral rinse solution of benzydamine hydrochloride 0.15% 3 times a day for 4 weeks, those in group B received a placebo 3 times a day for 4 weeks, and those in group C did not receive any kind of treatment. A visual analog scale was used for evaluation of the symptoms; a Kruskal-Wallis analysis of variance exact test was performed on the resulting data.


RESULTS
The findings of this investigation failed to reveal significant differences among the groups.


CONCLUSIONS
The clinical application of benzydamine hydrochloride oral rinses in the treatment of patients with burning mouth syndrome did not demonstrate significative efficacy in comparison with use of a placebo solution.
Sardella
A
A
Department of Oral Pathology and Medicine, School of Dentistry, University of Milan, Italy.
Uglietti
D
D
Demarosi
F
F
Lodi
G
G
Bez
C
C
Carrassi
A
A
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D001591:Benzydamine / Q000009:adverse effects / Q000627:therapeutic use*; D002054:Burning Mouth Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009067:Mouthwashes / Q000009:adverse effects / Q000627:therapeutic use*; D017211:Treatment Failure
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D009067:Mouthwashes; D001591:Benzydamine