title: A novel high-performance fourier transform ion cyclotron resonance cell for improved biopolymer characterization.
abstract: A new trapped ion cell design for use with Fourier transform ion cyclotron resonance mass spectrometry is described. The design employs 15 cylindrical ring electrodes to generate trapping potential wells and 32 separately assignable rod electrodes for excitation and detection. The rod electrodes are positioned internal to the ring electrodes and provide excitation fields that are thereby linearized along the magnetic field over the entire trapped ion volume. The new design also affords flexibility in the shaping of the trapping field using the 15 ring electrodes. Many different trapping well shapes can be generated by applying different voltages to the individual ring electrodes, ranging from quadratic to linearly ramped along the magnetic field axis, to a shape that is nearly flat over the entire trap volume, but rises very steeply near the ends of the trap. This feature should be useful for trapping larger ion populations and extension of the useful range of ion manipulation and dissociation experiments since the number of stages of ion manipulation or dissociation is limited in practice by the initial trapped ion population size. Predicted trapping well shapes for two different ring electrode configurations are presented, and these and several other possible configurations are discussed, as are the predicted excitation fields based on the use of rod electrodes internal to the trapping ring electrodes. Initial results are presented from an implementation of the design using a 3.5 T superconducting magnet. It was found that ions can be successfully trapped and detected with this cell design and that selected ion accumulation can be performed with the utilization of four rods for quadrupolar excitation. The initial results presented here illustrate the feasibility of this cell design and demonstrate differences in observed performance based upon different trapping well shapes.
authors.affiliation: Macromolecular Structures and Dynamics Group, Environmental and Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Bruce
authors.forename: G A
authors.initials: GA
authors.lastname: Anderson
authors.forename: C Y
authors.initials: CY
authors.lastname: Lin
authors.forename: M
authors.initials: M
authors.lastname: Gorshkov
authors.forename: A L
authors.initials: AL
authors.lastname: Rockwood
authors.forename: R D
authors.initials: RD
authors.lastname: Smith
mesh_terms: D001704:Biopolymers / Q000737:chemistry*; D017357:Cyclotrons; D004566:Electrodes; D005583:Fourier Analysis; D013058:Mass Spectrometry / Q000379:methods*
chemical_list: D001704:Biopolymers