Simvastatin-induced lupus-like syndrome.
The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are widely used as cholesterol lowering agents that have an acceptable safety profile. As a group, this class of drugs has been associated with few immunologic reactions. Simvastatin (Zocor) has been linked to three cases of drug-induced lupus-like syndrome. We report the case of an additional patient who developed pleurisy and arthralgia after he started taking this low-density lipoprotein and cholesterol-lowering agent.
Ahmad
A
A
Department of Internal Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0622, USA.
Fletcher
M T
MT
Roy
T M
TM
D000328:Adult; D000924:Anticholesteremic Agents / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced; D006801:Humans; D008177:Lupus Vulgaris / Q000139:chemically induced*; D008297:Male; D010998:Pleurisy / Q000139:chemically induced; D019821:Simvastatin / Q000009:adverse effects*
D000924:Anticholesteremic Agents; D019821:Simvastatin