Cytogenetic investigation of thallium-poisoned people: pilot study.
Thirteen blood samples of thallium-poisoned people were cytogenetically investigated. The thallium concentration in blood varied from 25 to 2700 microg/L. The mean frequency of chromosomal aberrations in the poisoned group significantly exceeded our control level (7.08+/--2.19% and 2.03+/--0.25, p<.001). The rate of single fragments was significantly higher in poisoned group (7.77+/-2.68% and 1.59+/-0.23%, p<.001) while the frequencies of other types of chromosomal aberrations were similar in both groups. It is possible that thallium is an S-dependent clastogenic agent because the majority of the structural aberrations are of the chromatid type. Irrespective of mechanisms, damage to genetic material was revealed in thallium-poisoned people.
Nikiforov
A
A
All Russian Centre of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg.
Slozina
N
N
Neronova
E
E
Kharchenko
T
T
Sosukin
A
A
Scherbak
S
S
Sarana
A
A
Onikienko
S
S
D000704:Analysis of Variance; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D015162:Micronucleus Tests; D010865:Pilot Projects; D011041:Poisoning / Q000097:blood; D013793:Thallium / Q000097:blood / Q000506:poisoning*
D013793:Thallium