title: [Streptokinase-induced jaundice].
abstract: Streptokinase is a thrombolytic agent used very frequently for the early treatment of acute myocardial infarction. A 35-year-old male with inferior acute myocardial infarction was admitted to the Coronary Care Unit and treated with systemic streptokinase. At the time of admission, he was a healthy male and he was not receiving any hepatotoxic agent. Six hours after thrombolysis, he developed high fever, painful hepatomegaly, jaundice and coluric urine. Leucocytosis with left deviation was observed in the hemogram and the liver function tests showed slight enzymatic elevation and hyperbilirubinemia. This condition was progressively improving and the patient was free of symptoms on the eighth day of evolution. Jaundice as secondary effect of streptokinase has been previously communicated in very few medical reports.
authors.affiliation: Unidad Coronaria, Hospital Universitario La Paz, Madrid.
authors.forename: J A
authors.initials: JA
authors.lastname: Gómez Guindal
authors.forename: I
authors.initials: I
authors.lastname: Roldán Rabadán
authors.forename: J
authors.initials: J
authors.lastname: Perea Egido
authors.forename: J A
authors.initials: JA
authors.lastname: Jurado López
authors.forename: A
authors.initials: A
authors.lastname: García de Frutos
authors.forename: L
authors.initials: L
authors.lastname: Martín Jadraque
mesh_terms: D000328:Adult; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D007565:Jaundice / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D013300:Streptokinase / Q000009:adverse effects*; D015912:Thrombolytic Therapy / Q000009:adverse effects; D013997:Time Factors
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase