title: Adaptation of iron absorption in men consuming diets with high or low iron bioavailability.
abstract: BACKGROUND
  Short-term measurements of iron absorption are substantially influenced by dietary bioavailability of iron, yet bioavailability negligibly affects serum ferritin in longer, controlled trials.
  
  
  OBJECTIVE
  Our objective was to test the hypothesis that in men fed diets with high or low iron bioavailability, iron absorption adapts to homeostatically maintain body iron stores.
  
  
  METHODS
  Heme- and nonheme-iron absorption from whole diets were measured in 31 healthy men at 0 and 10 wk while the men consumed weighed, 2-d repeating diets with either high or low iron bioavailability for 12 wk. The diets with high and low iron bioavailability contained, respectively, 14.4 and 15.3 mg nonheme Fe/d and 1.8 and 0.1 mg heme Fe/d and had different contents of meat, ascorbic acid, whole grains, legumes, and tea.
  
  
  RESULTS
  Adaptation occurred with nonheme- but not with heme-iron absorption. Total iron absorption decreased from 0.96 to 0.69 mg/d (P < 0.05) and increased from 0.12 to 0.17 mg/d (P < 0.05) after 10 wk of the high- and low-bioavailability diets, respectively. This partial adaptation reduced the difference in iron bioavailability between the diets from 8- to 4-fold. Serum ferritin was insensitive to diet but fecal ferritin was substantially lower with the low- than the high-bioavailability diet. Erythrocyte incorporation of absorbed iron was inversely associated with serum ferritin.
  
  
  CONCLUSIONS
  Iron-replete men partially adapted to dietary iron bioavailability and iron absorption from a high-bioavailability diet was reduced to approximately 0.7 mg Fe/d. Short-term measurements of absorption overestimate differences in iron bioavailability between diets.
authors.affiliation: US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202-9034, USA. jhunt@gfhnrc.ars.usda.gov
authors.forename: J R
authors.initials: JR
authors.lastname: Hunt
authors.forename: Z K
authors.initials: ZK
authors.lastname: Roughead
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001682:Biological Availability; D005243:Feces / Q000737:chemistry; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D007501:Iron / Q000097:blood; D019266:Iron, Dietary / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged
chemical_list: D019266:Iron, Dietary; D005293:Ferritins; D007501:Iron