title: [Successful pregnancy and delivery during alpha-interferon therapy for essential thrombocythemia].
abstract: Essential thrombocythemia (ET) was diagnosed in a 31-year-old woman who had a miscarriage in the first trimester of her first pregnancy. Because of her wish for child, the patient was given alpha interferon (alpha-IFN) instead of hydroxyurea or aspirin to lower her platelet count to about 80 x 10(4)/microliter. She also had a miscarriage in her second pregnancy. Thereafter, the platelet count was kept at 60-70 x 10(4)/microliter by dose escalation of alpha-IFN. In the 35th week of her third pregnancy, the patient delivered a healthy baby with a normal blood count. Several small infarctions were observed in the placenta. Control of platelet count by alpha-IFN administration was effective in preventing recurrent miscarriage associated with ET, and had no adverse effect on patient fertility or fetal development.
authors.affiliation: Division of Hematology, NTT Kanto Medical Center.
authors.forename: S
authors.initials: S
authors.lastname: Iki
authors.forename: K
authors.initials: K
authors.lastname: Usuki
authors.forename: M
authors.initials: M
authors.lastname: Kotaki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: A
authors.initials: A
authors.lastname: Urabe
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007743:Labor, Obstetric; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D013920:Thrombocythemia, Essential / Q000188:drug therapy*
chemical_list: D016898:Interferon-alpha