title: Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes.
abstract: Mononuclear nonheme-Fe(II)-dependent oxygenases comprise an extended family of oxidising enzymes, of which the 2-oxoglutarate-dependent oxygenases and related enzymes are the largest known subgroup. Recent crystallographic and mechanistic studies have helped to define the overall fold of the 2-oxoglutarate-dependent enzymes and have led to the identification of coordination chemistry closely related to that of other nonheme-Fe(II)-dependent oxygenases, suggesting related mechanisms for dioxygen activation that involve iron-mediated electron transfer.
authors.affiliation: Department of Chemistry, The Oxford Centre for Molecular Sciences, The Dyson Perrins Laboratory, Oxford, OX1 3QY, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Schofield
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D002384:Catalysis; D007656:Ketoglutaric Acids / Q000378:metabolism*; D008958:Models, Molecular; D010088:Oxidoreductases / Q000378:metabolism; D010105:Oxygenases / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D013379:Substrate Specificity
chemical_list: D007656:Ketoglutaric Acids; D010088:Oxidoreductases; D010105:Oxygenases; C038370:isopenicillin N synthetase; D000594:Amino Acid Oxidoreductases; C059460:1-aminocyclopropane-1-carboxylic acid oxidase