Renal responses of normal and preascitic broilers to systemic hypotension induced by unilateral pulmonary artery occlusion.
During the pathophysiological progression of pulmonary hypertension syndrome (PHS; ascites), broilers concurrently develop systemic hypotension (low mean systemic arterial pressure) that may initiate renal retention of water and solute, contributing to fluid accumulation in the abdominal cavity (ascites). In male Single Comb White Leghorns, glomerular filtration is autoregulated over a systemic arterial pressure range of 110 to 60 mm Hg, and corresponding reductions in urine flow are attributed to a phenomenon known as pressure natriuresis. Acute unilateral pulmonary artery occlusion was used in the present study to reduce systemic arterial pressure toward the lower autoregulatory limit for glomerular filtration, and to evaluate kidney function in normal and preascitic broilers. Preascitic broilers characteristically exhibited lower (P < or = 0.05) values for mean systemic arterial pressure (91 vs 100 mm Hg) and percentage saturation of hemoglobin with oxygen (73 vs 84%), higher hematocrits (35 vs 30%), heavier right ventricles (3.44 vs 2.32 g), and higher right:total ventricular weight ratios (0.32 vs 0.24) than normal broilers. Body weights (2,445 vs 2,429 g, respectively), left ventricle plus septum weights (7.16 vs 7.19 g), and heart rates (349 vs 341 beats/min) were similar. Preascitic broilers exhibited larger (P < or = 0.05) dependent reductions in glomerular filtration, urine flow, osmolal clearance, and solute excretion and had a higher free water clearance than normal broilers in response to pulmonary artery occlusion. The differences observed between normal and preascitic broilers demonstrate that systemic hypotension can trigger renal mechanisms contributing to fluid and solute retention during development of PHS.
Forman
M F
MF
Department of Poultry Science, University of Arkansas, Fayetteville 72701, USA. mforman@comp.uark.edu
Wideman
R F
RF
D000818:Animals; D001201:Ascites / Q000503:physiopathology / Q000662:veterinary*; D002645:Chickens; D003250:Constriction; D004231:Diuresis; D005919:Glomerular Filtration Rate; D006321:Heart; D006352:Heart Ventricles / Q000033:anatomy & histology; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006976:Hypertension, Pulmonary / Q000503:physiopathology / Q000662:veterinary; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology / Q000662:veterinary*; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009929:Organ Size; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood; D011201:Poultry Diseases / Q000209:etiology / Q000503:physiopathology*; D011651:Pulmonary Artery
D006454:Hemoglobins; D010100:Oxygen