title: Bone marrow: target for gene transfer.
abstract: Marrow cells are currently the most widely utilized target in human trials of gene therapies, and hematopoietic stem cells may be the best target of all. Able both to self-replicate and to engender blood cells in all lineages, they could be a lifelong source of therapeutic genes for disorders in any lineage. Hematopoietic stem cells may also portend the therapeutic use of even more versatile embryonic stem cells.
authors.affiliation: University of North Carolina, Chapel Hill School of Medicine, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Kirby
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology / Q000502:physiology*; D018014:Gene Transfer Techniques; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D019172:Transplantation Conditioning