Dual functions for transcriptional regulators: myth or reality?
Several transcriptional regulatory molecules have been described that appear to possess dual function in separate cellular compartments. It remains unclear whether the proteins really exert dual functions, or which of the transcriptional regulatory role or the cytoplasm-associated function is the physiologically relevant action of the protein. This review will briefly describe the cases at hand and attempt to sort the true bifunctional proteins from the aritfactual trespassers. J. Cell. Biochem. Suppls. 32/33:32-40, 1999.
St-Arnaud
R
R
Genetics Unit, Shriners Hospital for Children, and Departments of Surgery and Human Genetics, McGill University, Montreal, Quebec, Canada. rst-arnaud@shriners.mcgill.ca
D000074183:ATPases Associated with Diverse Cellular Activities; D048868:Adaptor Proteins, Signal Transducing; D000251:Adenosine Triphosphatases; D000818:Animals; D016477:Artifacts; D000075686:COP9 Signalosome Complex; D002352:Carrier Proteins / Q000502:physiology; D003593:Cytoplasm / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology; D006801:Humans; D006836:Hydro-Lyases / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D018832:Molecular Chaperones; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; D012097:Repressor Proteins / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D051176:beta Catenin
D048868:Adaptor Proteins, Signal Transducing; C495270:CTNNB1 protein, human; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D018832:Molecular Chaperones; C092282:PSMC5 protein, human; D012097:Repressor Proteins; C106843:SUG1 protein, mammalian; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051176:beta Catenin; C096099:nascent-polypeptide-associated complex; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases; C069670:RPT6 protein, S cerevisiae; D000074183:ATPases Associated with Diverse Cellular Activities; D006836:Hydro-Lyases; C076392:pterin-4a-carbinolamine dehydratase