Getting to the guts of enteroendocrine differentiation.
The endodermal epithelium of vertebrates generates many types of enteroendocrine cells, including the insulin- and glucagon-secreting cells of the islets of Langerhans. Two studies disclose that Notch signalling controls which cells differentiate as enteroendocrine cells-a finding with implications for therapeutic strategy.
Skipper
M
M
Lewis
J
J
D000818:Animals; D002454:Cell Differentiation; D004064:Digestive System / Q000166:cytology* / Q000378:metabolism; D004702:Endocrine Glands / Q000166:cytology* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D051880:Receptors, Notch; D015398:Signal Transduction
D008565:Membrane Proteins; D051880:Receptors, Notch