title: The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases.
abstract: Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.
authors.affiliation: Department of Chemistry, Brown University, Providence, RI 02912-9108, USA. David_Cane@brown.edu
authors.forename: D E
authors.initials: DE
authors.lastname: Cane
authors.forename: C T
authors.initials: CT
authors.lastname: Walsh
mesh_terms: D020134:Catalytic Domain; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D010442:Peptide Chain Initiation, Translational; D010443:Peptide Chain Termination, Translational; D010453:Peptide Synthases / Q000737:chemistry* / Q000378:metabolism; D011487:Protein Conformation; D012270:Ribosomes
chemical_list: D009097:Multienzyme Complexes; D010453:Peptide Synthases