title: Additional colloids have only a minor haemodilutive effect after surgery for aneurysmal subarachnoid haemorrhage.
abstract: Haemodilution is commonly used as prophylaxis, as well as treatment for cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). Thirty-six patients operated for aneurysmal SAH were evaluated retrospectively; 24 received haemodilutive therapy and 12 patients, as a control group, received no additional therapy. There was a 'spontaneous' drop in haematocrit by 22% in both groups, and a corresponding drop in haemoglobin by 23% in the treatment group and 19% in the non-haemodiluted group, during the first 4 days after the SAH. After the initial decrease the haematocrit remained stable between 0.28 and 0.33 until day 14 in both groups. The haemodilutive group had only a minor lower haematocrit level during days 8-12 as the additional fluid resulted in increased renal excretion. This minor difference was, however, significant (p < 0.02).
authors.affiliation: Department of Neurosurgery, University Hospital, Lund, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Ekelund
authors.forename: H
authors.initials: H
authors.lastname: Säveland
authors.forename: P
authors.initials: P
authors.lastname: Reinstrup
authors.forename: L
authors.initials: L
authors.lastname: Brandt
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000097:blood / Q000628:therapy*; D003102:Colloids / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D002532:Intracranial Aneurysm / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000097:blood / Q000628:therapy*; D017585:Ultrasonography, Doppler, Transcranial; D014882:Water-Electrolyte Balance
chemical_list: D003102:Colloids; D006441:Hemoglobin A