title: Cutaneous hyalohyphomycosis caused by Paecilomyces lilacinus in an immunocompetent host successfully treated with itraconazole: case report and review.
abstract: Paecilomyces lilacinus is an emerging fungal pathogen that is highly resistant to many antifungal drugs. Skin and subcutaneous soft tissue infections caused by this organism are very unusual. Most cases occur in patients with impaired host defenses or following surgical procedures. There has been only one previous report of a histologically confirmed cutaneous infection due to Paecilomyces lilacinus in a patient without predisposing factors. Described here is the second histopathologically proven case of Paecilomyces lilacinus cutaneous infection in a healthy patient without any apparent portal of entry. Prolonged antifungal chemotherapy with itraconazole led to resolution of the skin lesion. This case of sporadic cutaneous infection due to Paecilomyces lilacinus is believed to be the first reported in Europe and the first histopathologically proven case successfully treated with itraconazole.
authors.affiliation: Servicio de Medicina Interna, Hospital General Universitario de Elche, Alicante, Spain. fgutierrezr@medynet.com
authors.forename: F
authors.initials: F
authors.lastname: Gutiérrez-Rodero
authors.forename: M
authors.initials: M
authors.lastname: Moragón
authors.forename: V
authors.initials: V
authors.lastname: Ortiz de la Tabla
authors.forename: M J
authors.initials: MJ
authors.lastname: Mayol
authors.forename: C
authors.initials: C
authors.lastname: Martín
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D010143:Paecilomyces / Q000302:isolation & purification*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole