A comparative evaluation of some blood sugar lowering agents of plant origin.
A comparison of blood sugar lowering activity of four important medicinal plants (Azadirachta indica, Gymnema sylvestre, Catharanthus roseus and Ocimum sanctum) were carried out against normal and streptozotocin-induced diabetic rat models. The plant extracts decreased the blood sugar level in varying degrees. Blood sugar lowering unit (BLU) of activity of each leaf extract and tolbutamide was calculated by ED50 values. Statistical analysis revealed significant (P < 0.05) variation among the treatments as well as doses with regard to their blood sugar lowering capacity. A. indica leaf extract was found to have the most potent blood sugar-lowering activity followed by C. roseus, G. sylvestre and O. sanctum.
Chattopadhyay
R R
RR
Biometry Research Unit, Indian Statistical Institute, Calcutta.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013311:Streptozocin
D007004:Hypoglycemic Agents; D013311:Streptozocin