Neuropathies of monoclonal gammopathies of undetermined significance.
Although rare, MGUS neuropathies offer a unique glimpse of some the molecular mechanisms of autoimmunity. For this reason alone, they are important disorders and are being studied vigorously in many research centers around the world. In at least some cases, they are potentially treatable. New, safer, and more effective therapies are needed, however. The neurologist and hematologist must work together to develop these treatments.
Kelly
J J
JJ
George Washington University Medical Center, Washington, DC, USA. neujjk@gwumc.edu
D015551:Autoimmunity / Q000276:immunology; D064211:Connectin; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins; D009194:Myeloma Proteins / Q000276:immunology; D009422:Nervous System Diseases / Q000276:immunology*; D010265:Paraproteinemias / Q000276:immunology*
D064211:Connectin; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009124:Muscle Proteins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins