Prevention by carp extract of myelotoxicity and gastrointestinal toxicity induced by 5-fluorouracil without loss of antitumor activity in mice.
The combined effects of 5-fluorouracil (5-FU) and carp (Cyprinus carpio L.) extract on antitumor activity, myelotoxicity and gastrointestinal toxicity were examined in sarcoma 180-bearing mice. Carp extract was found to prevent the occurrence of myelotoxicity as determined by the reduction of leukocyte number, and of gastrointestinal toxicity, as determined by the reduction of small intestinal weight, induced by 5-FU without loss of the antitumor activity of 5-FU.
Kimura
Y
Y
2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Onsen-gun, Japan. yokim@m.ehime.-u.ac.jp
Okuda
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H
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use* / Q000633:toxicity; D001855:Bone Marrow Diseases / Q000139:chemically induced / Q000517:prevention & control*; D002347:Carps; D056486:Chemical and Drug Induced Liver Injury; D005227:Fatty Acids / Q000032:analysis; D005472:Fluorouracil / Q000627:therapeutic use* / Q000633:toxicity*; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control*; D007958:Leukocyte Count / Q000187:drug effects; D008107:Liver Diseases / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012513:Sarcoma, Experimental / Q000188:drug therapy; D014020:Tissue Extracts / Q000737:chemistry / Q000627:therapeutic use*
D000596:Amino Acids; D000964:Antimetabolites, Antineoplastic; D005227:Fatty Acids; D014020:Tissue Extracts; D005472:Fluorouracil