title: Corneal ulceration in the elderly in Hyderabad, south India.
abstract: OBJECTIVE
  To report demographic, microbiological, therapeutic, anatomical, and visual results of corneal ulceration in the elderly patients seen at a tertiary eye care centre in south India.
  
  
  METHODS
  102 consecutive cases of microbial keratitis in patients 65 years and older were studied. Inclusion criteria were: (i) presence of corneal stromal infiltrate upon slit lamp examination; and (ii) microbiological evaluation of corneal scrapings for suspected microbial keratitis.
  
  
  RESULTS
  The principal predisposing factors identified in this study were ocular disease (38.2%), previous ocular surgery in the same eye (29.4%), trauma (17.6%), and severe systemic disease (16.7%). Contact lens wear was associated with only two cases (2.0%). 99 organisms were isolated in cultures of corneal scrapings from 74 (72.5%) of the 102 cases. Staphylococcus epidermidis (31.1%), filamentous fungi (25.7%), and Streptococcus pneumoniae (13.5%) were the most common isolates. 12 eyes (11.8%) required surgery, 15 (14.7%) eventually required evisceration, and nine (9.6%) of the 94 followed patients achieved an unaided vision of 20/60 or better at last follow up.
  
  
  CONCLUSIONS
  This work represents the largest recent single centre study on (non-viral) microbial keratitis in the elderly, its management, and outcomes of therapy. While the predisposing factors differ from those of general population, the spectrum of microbes responsible for keratitis in the elderly appears to reflect the local microbial flora rather than a predilection for elderly patients. Delay in diagnosis and systemic conditions associated with advancing age probably contribute to poorer outcome from therapeutic measures.
authors.affiliation: Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Kunimoto
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: P
authors.initials: P
authors.lastname: Garg
authors.forename: U
authors.initials: U
authors.lastname: Gopinathan
authors.forename: D
authors.initials: D
authors.lastname: Miller
authors.forename: G N
authors.initials: GN
authors.lastname: Rao
mesh_terms: D015823:Acanthamoeba Keratitis / Q000150:complications; D000368:Aged; D000369:Aged, 80 and over; D003320:Corneal Ulcer / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D005128:Eye Diseases / Q000150:complications / Q000382:microbiology; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D009181:Mycoses / Q000150:complications; D015995:Prevalence; D017678:Sex Distribution; D013203:Staphylococcal Infections / Q000150:complications; D013212:Staphylococcus epidermidis; D013290:Streptococcal Infections / Q000150:complications; D013296:Streptococcus pneumoniae