title: Bone non-union after osteotomy in patients treated with methotrexate.
abstract: We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.
authors.affiliation: University Rheumatology and Rehabilitation Center, CHUV, Lausanne, Switzerland.
authors.forename: J C
authors.initials: JC
authors.lastname: Gerster
authors.forename: R
authors.initials: R
authors.lastname: Bossy
authors.forename: J
authors.initials: J
authors.lastname: Dudler
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D002146:Bony Callus / Q000000981:diagnostic imaging / Q000187:drug effects*; D000075202:Contraindications; D006801:Humans; D008297:Male; D008682:Metatarsal Bones / Q000503:physiopathology / Q000601:surgery; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D010027:Osteotomy; D011859:Radiography; D013977:Tibia / Q000503:physiopathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate