Multimodal spatial orientation deficits in left-sided visual neglect.
Patients with right-sided temporo-parietal lesions often show contralesional neglect. However, neglect patients may also show spatial-perceptual deficits beyond the bisection and space exploration deficits frequently assessed in the horizontal plane, that is, deficits in the judgment of the subjective visual vertical or horizontal. In a recent study (Kerkhoff, G. & Zoelch, C.. Disorders of visuo-spatial orientation in the frontal plane in patients with visual neglect following right or left parietal lesions. Exp. Brain Res., 1998;122:108-120) we found significant perturbations in the perception of these three visual spatial axes in patients with contralesional neglect from right or left parietal lesions. To examine if this finding extends also to another modality we investigated how neglect patients perform tasks of visual- and tactile-spatial judgments of axis-orientation in the frontal plane. Visual-spatial and tactile-spatial judgments of the subjective vertical, horizontal and a right oblique orientation were obtained from patients with and without neglect as well as from normal subjects. Patients with left neglect showed a significant, contraversive tilt of all three visual-spatial axes (+5.6 degrees to +9.5 degrees, counterclockwise), and of the three tactile-spatial axes as well (+5.2 degrees to +10.5 degrees, counterclockwise). In contrast, right and left hemisphere lesioned control patients without neglect and normal control subjects showed unimpaired visual and tactile-spatial judgments (constant errors: < 1.0 degree). Difference thresholds in the visual-spatial tasks and unsigned errors in the tactile-spatial tasks were selectively elevated in the neglect group in contrast to all other subject groups. Spatial orientation deficits were significantly associated with the severity of clinical neglect (r = 0.55-0.88), and with the patients' ambulation performance (r = 0.45-0.70). Furthermore, crossmodal axis orientation tests in two neglect patients showed a similar counterclockwise tilt of +5 degrees to +15 degrees, suggesting a similar spatial deficit in both modalities. Orientation judgments were significantly aggravated by a 25 degree-tilt of the head to the left, as tested in one neglect patient, while a comparable rightward head-tilt improved spatial judgments in both modalities. This suggests that spatial orientation judgments are significantly modulated by gravitational input in neglect patients. Together these results are interpreted as evidence for multisensory spatial orientation deficits in neglect patients which are modulated by head-position and are related to their accompanying postural impairment.
Kerkhoff
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EKN, Clinical Neuropsychology Research Group, Krankenhaus Bogenhausen, München, Germany. ekn@extern.lrz-muenchen.de
D000328:Adult; D005260:Female; D007839:Functional Laterality; D006257:Head; D006801:Humans; D008297:Male; D008875:Middle Aged; D009949:Orientation; D011187:Posture; D013028:Space Perception; D014786:Vision Disorders / Q000503:physiopathology*; D014796:Visual Perception