Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.
Node biopsies of 16 benign lymphadenopathies and 72 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for counts of microvessels, total metachromatic mast cells (MCs) and MCs expressing tryptase, an angiogenesis-inducing molecule. Counts were higher in B-NHLs. When grouped according to the Working Formulation (WF) malignancy grades, they were significantly higher in low-grade B-NHLs vs. lymphadenopathies and intermediate-grade vs. low-grade tumors and there was a further increase in the high-grade tumors. A high correlation was demonstrated in all groups of tissues between microvessel counts and both total metachromatic and tryptase-reactive MCs. These results suggest that angiogenesis in B-NHLs increases with their progression, and that MCs cooperate in its induction via the tryptase contained in their secretory granules.
Ribatti
D
D
Institute of Human Anatomy, Histology and Embryology University of Bari Medical School, Bari, Italy. ribatti@anatomia.uniba.it
Vacca
A
A
Marzullo
A
A
Nico
B
B
Ria
R
R
Roncali
L
L
Dammacco
F
F
D053818:Chymases; D018450:Disease Progression; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000201:enzymology / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008407:Mast Cells / Q000201:enzymology*; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D012697:Serine Endopeptidases / Q000378:metabolism*; D053802:Tryptases
D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases