[Clinico-pathogenetic features of viral hepatitis A course].
OBJECTIVE
To study mechanisms enhancing realization of autoimmune disorders in acute viral hepatitis A at initial stages.


METHODS
32 patients with moderate and 4 patients with severe VHA (17 females and 19 males, age from 15 to 38 years) verified by finding serum anti-HAV IgM at enzyme immunoassay (EIA) have undergone examination which included: measurement of beta 2-microglobulin, C5-components of complement, circulating immune complexes (CIC), zero lymphocytes; test for antinuclear antibodies (ANA) and smooth muscle antibodies (SMA).


RESULTS
All the patients exhibited high levels of beta 2-microglobulin, zero lymphocytes, CIC, low concentration of C5-components of complement. SMA were detected at the height of intoxication in 27 patients, in early convalescence--in 31 patients. ANA were discovered only in one patient.


CONCLUSIONS
The findings suggest development of autoimmune reactions in acute VHA patients. These reactions may trigger onset of autoimmune hepatitis.
Pak
S G
SG
Volchkova
E V
EV
Umbetova
K T
KT
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000097:blood; D015551:Autoimmunity / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D003182:Complement C5 / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000276:immunology* / Q000821:virology; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000032:analysis*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology; D001613:beta 2-Microglobulin / Q000097:blood
D000974:Antibodies, Antinuclear; D000936:Antigen-Antibody Complex; D015415:Biomarkers; D003182:Complement C5; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies; D001613:beta 2-Microglobulin