Uneven distribution of hepatitis C virus quasispecies in tissues from subjects with end-stage liver disease: confounding effect of viral adsorption and mounting evidence for the presence of low-level extrahepatic replication.
We have found differences among the populations of hepatitis C virus sequences in serum, peripheral blood mononuclear cells (PBMCs), and various tissues in patients with chronic hepatitis C. These results are compatible with the existence of independent viral compartments in the infected host. Our results also suggest that PBMCs, and probably various tissues, can selectively adsorb viral subpopulations differing in the E2 region.
Laskus
T
T
Division of Gastroenterology and Hepatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA. laskus.tomasz@mayo.edu
Radkowski
M
M
Wang
L F
LF
Nowicki
M
M
Rakela
J
J
D020121:5' Untranslated Regions; D000327:Adsorption; D001483:Base Sequence; D016174:Hepacivirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D019698:Hepatitis C, Chronic / Q000097:blood / Q000473:pathology / Q000821:virology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000821:virology; D017093:Liver Failure / Q000473:pathology / Q000821:virology*; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D014018:Tissue Distribution; D014759:Viral Envelope Proteins / Q000235:genetics; D014771:Virion; D014779:Virus Replication
D020121:5' Untranslated Regions; D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus