Tetrasomy 8 evolving into a segmental triplication 8q in a case of acute monocytic leukemia.
We report a case of AML-M5 with tetrasomy 8 that evolved within a 7-month period to a segmental triplication 8q. Other numerical abnormalities in the initial diagnosis were not found at the relapse; however, a chromosome 1 structural abnormality was maintained, proving the clonal evolution from tetrasomy 8 to a segmental triplication of the long arm of 8. This strongly suggests that there is a functional and selective advantage for duplications and triplications of 8q in these patients.
Qumsiyeh
M B
MB
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Cheng
C
C
Eyre
J
J
Mann
K P
KP
Zhang
X X
XX
D000368:Aged; D000782:Aneuploidy; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002878:Chromosomes, Human, Pair 1; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18; D002895:Chromosomes, Human, Pair 5; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007948:Leukemia, Monocytic, Acute / Q000235:genetics*; D008297:Male