Endothelin and post-ganglionic sympathetic neurons.
1. The present report documents evidence suggesting that endothelin (ET) is a mediator and modulator of post-ganglionic sympathetic neuronal development. 2. Endothelin is produced by post-ganglionic neurons and by cells adjacent to these neurons. 3. Post-ganglionic sympathetic neurons express functional receptors for ET. 4. Endothelin promotes the survival of cultured post-ganglionic sympathetic neurons and modulates the morphological and biochemical differentiation of these neurons. 5. Endothelin enhances the activity of nerve growth factor and modulates the release of neurotransmitter from post-ganglionic sympathetic nerve terminals.
Damon
D H
DH
Department of Pharmacology, University of Vermont, Burlington 05405, USA. ddamon@zoo.uvm.edu
D000818:Animals; D016232:Endothelins / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D017779:Sympathetic Fibers, Postganglionic / Q000502:physiology*
D016232:Endothelins