Effects of microinjections of triazolam into the ventrolateral preoptic area on sleep in the rat.
In view of interest in the ventrolateral preoptic area (VLPO), based on FOS protein accumulation during sleep as well as its output pathways to areas involved in sleep regulation, we have examined the effects of microinjections of triazolam into the VLPO. It was found that two doses of triazolam, noted previously to enhance sleep when injected into the medial preoptic area, had no significant effect on sleep or core temperature when administered into the VLPO. Although these data do not bear on the possibility that the VLPO is involved in physiological sleep regulation, they suggest that it is not a site of the pharmacologic action of hypnotic benzodiazepines.
Mendelson
W B
WB
Department of Psychiatry, The University of Chicago, Illinois 60637, USA. wmendels@yoda.bsd.uchicago.edu
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D008297:Male; D008845:Microinjections; D011301:Preoptic Area / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D014229:Triazolam / Q000008:administration & dosage* / Q000494:pharmacology
D014151:Anti-Anxiety Agents; D014229:Triazolam