Mechanisms for cytoplasmic organization: an overview.
One of the basic characteristics of life is the intrinsic organization of cytoplasm, yet we know surprisingly little about the manner in which cytoplasmic macromolecules are arranged. It is clear that cytoplasm is not the homogeneous "soup" it was once envisioned to be, but a comprehensive model for cytoplasmic organization is not available in modern cell biology. The premise of this volume is that phase separation in cytoplasm may play a role in organization at the subcellular level. Other mechanisms for non-membrane-bounded intracellular organization have previously been proposed. Some of these will be reviewed in this chapter. Multiple mechanisms, involving phase separation, specific intracellular targeting, formation of macromolecular complexes, and channeling, all could well contribute to cytoplasmic organization. Temporal and spatial organization, as well as composition, are likely to be important in defining the characteristics of cytoplasm.
Pagliaro
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Cerep, Inc., Redmond, Washington 98052, USA.
D000818:Animals; D001692:Biological Transport; D003593:Cytoplasm / Q000502:physiology*; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology*; D046911:Macromolecular Substances
D046911:Macromolecular Substances