CCR5 delta32, matrix metalloproteinase-9 and disease activity in multiple sclerosis.
Chemokines and matrix metalloproteinases (MMPs) appear to be crucial in leukocyte recruitment to the central nervous system in multiple sclerosis (MS). CCR5 delta32, a truncated allele of the CC chemokine receptor CCR5 gene encoding a non-functional receptor, did not confer protection from MS. CCR5 delta32 was, however, associated with a lower risk of recurrent clinical disease activity. High CSF levels of MMP-9 activity were also associated with recurrent disease activity. These results directly link intrathecal inflammation to disease activity in patients with MS, suggesting that treatments targeting CCR5 or treatment with MMP inhibitors may attenuate disease activity in MS.
Sellebjerg
F
F
Department of Neurology, University of Copenhagen, Glostrup Hospital, Denmark. sellebjerg@dadlnet.dk
Madsen
H O
HO
Jensen
C V
CV
Jensen
J
J
Garred
P
P
D000328:Adult; D000483:Alleles; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000134:cerebrospinal fluid*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D009187:Myelitis / Q000134:cerebrospinal fluid; D019713:Receptors, CCR5 / Q000235:genetics* / Q000378:metabolism*; D012008:Recurrence; D012016:Reference Values; D012307:Risk Factors
D019713:Receptors, CCR5; D020780:Matrix Metalloproteinase 9