title: Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimetic.
authors.affiliation: Research & Development Division, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA. williamvhvmiller@sbphrd.com
authors.forename: W H
authors.initials: WH
authors.lastname: Miller
authors.forename: D P
authors.initials: DP
authors.lastname: Alberts
authors.forename: P K
authors.initials: PK
authors.lastname: Bhatnagar
authors.forename: W E
authors.initials: WE
authors.lastname: Bondinell
authors.forename: J F
authors.initials: JF
authors.lastname: Callahan
authors.forename: R R
authors.initials: RR
authors.lastname: Calvo
authors.forename: R D
authors.initials: RD
authors.lastname: Cousins
authors.forename: K F
authors.initials: KF
authors.lastname: Erhard
authors.forename: D A
authors.initials: DA
authors.lastname: Heerding
authors.forename: R M
authors.initials: RM
authors.lastname: Keenan
authors.forename: C
authors.initials: C
authors.lastname: Kwon
authors.forename: P J
authors.initials: PJ
authors.lastname: Manley
authors.forename: K A
authors.initials: KA
authors.lastname: Newlander
authors.forename: S T
authors.initials: ST
authors.lastname: Ross
authors.forename: J M
authors.initials: JM
authors.lastname: Samanen
authors.forename: I N
authors.initials: IN
authors.lastname: Uzinskas
authors.forename: J W
authors.initials: JW
authors.lastname: Venslavsky
authors.forename: C C
authors.initials: CC
authors.lastname: Yuan
authors.forename: R C
authors.initials: RC
authors.lastname: Haltiwanger
authors.forename: M
authors.initials: M
authors.lastname: Gowen
authors.forename: S M
authors.initials: SM
authors.lastname: Hwang
authors.forename: I E
authors.initials: IE
authors.lastname: James
authors.forename: M W
authors.initials: MW
authors.lastname: Lark
authors.forename: D J
authors.initials: DJ
authors.lastname: Rieman
authors.forename: G B
authors.initials: GB
authors.lastname: Stroup
authors.forename: L M
authors.initials: LM
authors.lastname: Azzarano
authors.forename: K L
authors.initials: KL
authors.lastname: Salyers
authors.forename: B R
authors.initials: BR
authors.lastname: Smith
authors.forename: K W
authors.initials: KW
authors.lastname: Ward
authors.forename: K O
authors.initials: KO
authors.lastname: Johanson
authors.forename: W F
authors.initials: WF
authors.lastname: Huffman
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D001682:Biological Availability; D001862:Bone Resorption / Q000517:prevention & control; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D006207:Half-Life; D006801:Humans; D018716:Molecular Mimicry; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism; D011725:Pyridines / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats; D019030:Receptors, Vitronectin / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D014018:Tissue Distribution
chemical_list: D001552:Benzazepines; D011725:Pyridines; D019030:Receptors, Vitronectin