title: The role of the tumor necrosis factor system and interleukin-10 during cytomegalovirus infection in renal transplant recipients.
abstract: The effects of cytomegalovirus (CMV) infection on monocyte and T cell activation and the role of the tumor necrosis factor (TNF) system and interleukin (IL)-10 were studied in a prospective study of 25 renal transplant recipients. Ten patients developed CMV disease (group A), 5 developed asymptomatic infection (group B), and 10 did not have CMV infection (group C). During CMV disease (group A), there was evidence of both monocyte and T cell activation. All patients with CMV infection (groups A and B) showed increased activation of the TNF system, concomitant with an increase in plasma levels of IL-10. Patients with CMV disease (group A) had more marked manifestations of TNF activation and more moderate IL-10 increase than patients with asymptomatic CMV infection (group B), reflected in a higher plasma IL-10/TNF-alpha ratio in asymptomatic patients. Thus, the balance between TNF-alpha and IL-10 may be important in the development of CMV infection and CMV-related disease.
authors.affiliation: Section of Clinical Immunology, Research Institute of Internal Medicine, Medical Dept., Rikshospitalet, N-0027 Oslo, Norway. ingvild.nordoy@klinmed.uio.no
authors.forename: I
authors.initials: I
authors.lastname: Nordøy
authors.forename: F
authors.initials: F
authors.lastname: Müller
authors.forename: K P
authors.initials: KP
authors.lastname: Nordal
authors.forename: H
authors.initials: H
authors.lastname: Rollag
authors.forename: E
authors.initials: E
authors.lastname: Lien
authors.forename: P
authors.initials: P
authors.lastname: Aukrust
authors.forename: S S
authors.initials: SS
authors.lastname: Froland
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10