Redox regulation of signal transduction in mammalian cells.
This mini-review addresses the mechanism of ultraviolet-light-induced activation of receptor tyrosine kinases. The experimental approach into this mechanism revealed the existence of redox regulation of signal transduction in mammalian cells. It is postulated that, in addition to responsiveness to oxidative attacks from outside, redox regulation of specific redox-sensitive proteins likely represents an important physiological mechanism.
Herrlich
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Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, and University of Karlsruhe, Institute of Genetics, Germany. genetik@igen.fzk.de
Böhmer
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D000818:Animals; D008024:Ligands; D008322:Mammals; D008670:Metals / Q000378:metabolism / Q000633:toxicity; D010084:Oxidation-Reduction; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism* / Q000528:radiation effects; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013379:Substrate Specificity; D014466:Ultraviolet Rays
D008024:Ligands; D008670:Metals; D020794:Receptor Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases