[Anabolic therapy in patients with HIV infections].
OBJECTIVE
To assess effectiveness of Deka-Duraboline--preparation of anabolic steroid hormone (nandrolone decanoate)--in the treatment of weight loss in AIDS patients.


METHODS
13 AIDS patients with weight loss < 10% admitted to Moscow Center of AIDS Prevention and Treatment were given Deka-Durabolin 1 time a week 50 mg intramuscularly for 12 weeks after failure of attempts to arrest weight loss. Body mass, diarrhea, appetite and general condition (visual analogue scale) were studied.


RESULTS
Deka-Duraboline treatment arrested weight loss in 12 of 13 cases, improved well-being. All the patients displayed better appetite, reduced diarrhea.


CONCLUSIONS
Deka-Duraboline is effective in improving body weight, appetite, diarrhea and well-being in AIDS patients. It is advisable to further study Deka-Duraboline in a controlled randomized trial.
Gruzdev
B M
BM
Ivannikov
E V
EV
Gorbacheva
E S
ES
D000328:Adult; D045930:Anabolic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001066:Appetite / Q000187:drug effects; D015992:Body Mass Index; D003967:Diarrhea / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011788:Quality of Life; D016896:Treatment Outcome; D015431:Weight Loss / Q000187:drug effects
D045930:Anabolic Agents; D009277:Nandrolone; C008580:nandrolone phenpropionate