Primary lymphoplasmacytoid lymphoma of the trachea with immunoglobulin G paraprotein.
A primary tracheal lymphoma with immunoglobulin G (IgG)-associated monoclonal serum paraprotein treated with surgery and chemotherapy is reported. As far as we know this is the first lymphoplasmacytoid lymphoma reported in the tracheobronchial tree and the first with a serum and tissue IgG monoclonal paraprotein. Differential diagnosis must be made essentially with extramedullary plasmacytoma and mucosa-associated lymphoid tissue lymphoma. CD-45RB strong positivity and the absence of lymphoepithelial lesions may help to differentiate lymphoplasmacytoid lymphoma from them. We expand the spectrum of lymphoid lesions with plasmacytoid features that can occur in the tracheobronchial tract.
Gómez-Román
J J
JJ
Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Santander, Spain.
Pérez-Montes
R
R
Pérez-Expósito
M A
MA
Richard
C
C
Baro
J
J
Val-Bernal
J F
JF
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D017493:Leukocyte Common Antigens / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D010265:Paraproteinemias / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D011241:Prednisone / Q000008:administration & dosage; D014134:Tracheal Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D014750:Vincristine / Q000008:administration & dosage
D014408:Biomarkers, Tumor; D007074:Immunoglobulin G; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014750:Vincristine; D003520:Cyclophosphamide; D017493:Leukocyte Common Antigens; D011241:Prednisone