Antibacterial hydroxycinnamic esters from Piper caninum from Paluma, north Queensland, Australia. The crystal and molecular structure of (+)-bornyl coumarate.
The crude chloroform bark extract of Piper caninum (Piperaceae) exhibits antibacterial activity against the Gram-positive bacteria, Bacillus cereus, Staphylococcus aureus, and Streptococcus pneumoniae. The antibacterial agents in this extract have been isolated using bioactivity-directed chromatographic techniques and identified by NMR spectroscopy as (+)-bornyl p-coumarate and bornyl caffeate. A single-crystal X-ray structure has been carried out on (+)-bornyl p-coumarate. The compound crystallizes in the orthorhombic space group P2(1)2(1)2(1) (#19) with a = 12.659(4), b = 13.281(4), and c = 10.177(3) A. Fullmatrix least-squares refinement converged at R = 0.047, and Rw = 0.058.
Setzer
W N
WN
Setzer
M C
MC
Bates
R B
RB
Nakkiew
P
P
Jackes
B R
BR
Chen
L
L
McFerrin
M B
MB
Meehan
E J
EJ
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003373:Coumaric Acids / Q000737:chemistry*; D004952:Esters; D008958:Models, Molecular; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D003373:Coumaric Acids; D004952:Esters