title: [Clinical and epidemiological characteristics of severe poisoning in an adult population admitted to an intensive care unit].
abstract: OBJECTIVE
  To describe the clinical and epidemiological features of severe acute poisonings in an adult population.
  
  
  METHODS
  Retrospective analysis of clinical cases.
  
  
  METHODS
  Analysis of the clinical charts, risk factors and main outcomes of 55 acute poisoned patients admitted to an intensive care unit (ICU).
  
  
  RESULTS
  Of the 55 clinical charts reviewed, female prevailed over male gender with a relation of 1.5:1, the average age was 32 years (16-83 years), the major etiologic factor for the acute poisonings were drugs in 35 cases (64%), and home or work chemicals in 20 cases (36%). The mechanisms of intoxication/poisoning were: attempted or successful suicide in 51 cases (93%), accidental poisoning in three cases (5%), and iatrogenic in one case (2%). Precipitating factors were major depressive disorder in 29 cases (53%), dysthymic disorder in 12 cases (22%) and adjustment disorder with depressive mood or impulsive act in nine cases (16%). Associated feature comorbid conditions were: homosexuality, schizophrenia, drug addiction, AIDS, other chronic diseases, and previous suicide attempts. Outcomes were 33 (60%) patients discharged from the ICU without sequela, seven (13%) with permanent severe sequela and 15 (27%) deaths.
  
  
  CONCLUSIONS
  There was a high rate of suicides related with depressive disorders in a predominantly female population. Drug products were used more frequently than home or work chemicals. Although advanced life support and antidotal treatments were available, mortality was high. Areas where injury prevention efforts might have an influence on adult poisoning morbidity and mortality include management of depression as well suitable control of drugs and chemicals.
authors.forename: G
authors.initials: G
authors.lastname: Juárez-Aragón
authors.forename: J A
authors.initials: JA
authors.lastname: Castañón-González
authors.forename: A J
authors.initials: AJ
authors.lastname: Pérez-Morales
authors.forename: M A
authors.initials: MA
authors.lastname: Montoya Cabrera
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011041:Poisoning / Q000453:epidemiology* / Q000523:psychology; D012307:Risk Factors; D012737:Sex Factors; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data*; D013406:Suicide, Attempted / Q000523:psychology / Q000706:statistics & numerical data