Hypocretin (orexin) deficiency in human narcolepsy.
Alterations in the hypocretin receptor 2 and preprohypocretin genes produce narcolepsy in animal models. Hypocretin was undetectable in seven out of nine people with narcolepsy, indicating abnormal hypocretin transmission.
Nishino
S
S
Ripley
B
B
Overeem
S
S
Lammers
G J
GJ
Mignot
E
E
D000328:Adult; D000368:Aged; D000818:Animals; D002352:Carrier Proteins; D004285:Dogs; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008875:Middle Aged; D009290:Narcolepsy / Q000134:cerebrospinal fluid / Q000235:genetics / Q000378:metabolism*; D009479:Neuropeptides; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid / Q000172:deficiency* / Q000235:genetics; D000068797:Orexins
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D000068797:Orexins