title: Melanoma in the gastrointestinal tract.
abstract: OBJECTIVE
  This article focuses on the clinical, diagnostic, and therapeutic aspects of malignant melanoma metastases to the gastrointestinal (GI) tract. The subject of primary malignant melanoma arising from the GI tract is also discussed. Malignant melanoma is the most common tumor metastatic to the GI tract, and can present with fairly non-specific symptoms.
  
  
  METHODS
  Up to 60% of patients with melanoma are found to have metastases at autopsy. Frequent GI sites of invasion include the small bowel (50%), colon (31.3%), and anorectum (25%), seen in our institution over the past 9 yr. Malignant melanoma is a frequent source of metastases to the gastrointestinal (GI) tract.
  
  
  RESULTS
  Herein we report the case of a melanoma masquerading as a rectal polyp. We have also discovered 16 cases of melanoma metastases to the GI tract, at our institution, over the past 9 yr. The most frequent sites included small bowel (50%), colon (31.3%), and anorectum (25%).
  
  
  CONCLUSIONS
  Despite innocuous gastrointestinal symptoms, metastatic melanoma should be a diagnostic consideration in any patient with a history of melanoma.
authors.affiliation: Department of Medicine, University of Pennsylvania Health System, Philadelphia, USA.
authors.forename: D
authors.initials: D
authors.lastname: Blecker
authors.forename: S
authors.initials: S
authors.lastname: Abraham
authors.forename: E E
authors.initials: EE
authors.lastname: Furth
authors.forename: M L
authors.initials: ML
authors.lastname: Kochman
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004064:Digestive System / Q000473:pathology; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology