Microwaves and cellular immunity. II. Immunostimulating effects of microwaves and naturally occurring antioxidant nutrients.
The effect of 8.15-18 GHz (1 Hz within) microwave radiation at a power density of 1 microW/cm2 on the tumor necrosis factor (TNF) production and immune response was tested. A single 5 h whole-body exposure induced a significant increase in TNF production in peritoneal macrophages and splenic T cells. The mitogenic response in T lymphocytes increased after microwave exposure. The activation of cellular immunity was observed within 3 days after exposure. The diet containing lipid-soluble nutrients (beta-carotene, alpha-tocopherol and ubiquinone Q9) increased the activity of macrophages and T cells from irradiated mice. These results demonstrate that irradiation with low-power density microwaves stimulates the immune potential of macrophages and T cells, and the antioxidant treatment enhances the effect of microwaves, in particular at later terms, when the effect of irradiation is reduced.
Novoselova
E G
EG
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow, Russian Federation. elenanov@icb.psn.ru
Fesenko
E E
EE
Makar
V R
VR
Sadovnikov
V B
VB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D007111:Immunity, Cellular / Q000187:drug effects* / Q000528:radiation effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008872:Microwaves; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects
D000975:Antioxidants