title: Systemic consequences of oxidative stress following aortic surgery correlate with the degree of antioxidant defenses.
abstract: The purpose of this study was to correlate the preoperative level of antioxidant defenses, measured by the plasma total antioxidant capacity (TAC), to the degree of postoperative systemic inflammatory response, measured by the severity of pulmonary injury following elective aortic surgery. Twenty-four patients had TAC measured preoperatively and 24 hr postoperatively. Chest radiography and arterial blood gases were obtained preoperatively and serially during the first 24 hr after surgery. Using objective radiologic criteria and blood gas analysis, the degree of pulmonary edema and pulmonary dysfunction were quantified. All patients showed evidence of pulmonary dysfunction in the first 24 hr following surgery. Fifteen of the 24 patients showed radiographic evidence of noncardiogenic pulmonary edema in the immediate postoperative period. In this group, the TAC was lower than in those without pulmonary edema immediately following surgery (p = 0.03). Preoperative TAC was associated with the degree of pulmonary edema in the postoperative period (r = -0.372, p = 0.067). These results suggest that preoperative antioxidant supplementation may favorably impact the severity of systemic inflammatory response following ischemia and reperfusion injury.
authors.affiliation: Department of Surgery, Western Reserve Care System, Youngstown, OH 44501, USA.
authors.forename: G
authors.initials: G
authors.lastname: Cornu-Labat
authors.forename: M
authors.initials: M
authors.lastname: Serra
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: W E
authors.initials: WE
authors.lastname: McGregor
authors.forename: K
authors.initials: K
authors.lastname: Kasirajan
authors.forename: M K
authors.initials: MK
authors.lastname: Hirko
authors.forename: J J
authors.initials: JJ
authors.lastname: Turner
authors.forename: J R
authors.initials: JR
authors.lastname: Rubin
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000032:analysis*; D001014:Aortic Aneurysm / Q000097:blood* / Q000601:surgery; D001018:Aortic Diseases / Q000097:blood* / Q000601:surgery; D019917:Blood Vessel Prosthesis Implantation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011184:Postoperative Period; D011446:Prospective Studies; D011654:Pulmonary Edema / Q000503:physiopathology; D015427:Reperfusion Injury / Q000097:blood; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*
chemical_list: D000975:Antioxidants