title: Bacteremic pneumonia caused by a single clone of Streptococcus pneumoniae with different optochin susceptibilities.
abstract: Two isolates of Streptococcus pneumoniae having different optochin susceptibilities were recovered from a blood sample of a 2-year-old boy with community-acquired pneumonia. The two isolates were documented to belong to a single clone on the basis of the isolates' identical serotype (23F), antibiograms by the E-test, random amplified polymorphic DNA patterns generated by arbitrarily primed PCR, pulsed-field gel electrophoresis, and restriction fragment length polymorphism of the penicillin-binding protein genes pbp2b and pbp2x.
authors.affiliation: Department of Pediatrics, Taipei Municipal Ho-Ping Hospital, Taipei, Taiwan.
authors.forename: H Y
authors.initials: HY
authors.lastname: Tsai
authors.forename: P R
authors.initials: PR
authors.lastname: Hsueh
authors.forename: L J
authors.initials: LJ
authors.lastname: Teng
authors.forename: P I
authors.initials: PI
authors.lastname: Lee
authors.forename: L M
authors.initials: LM
authors.lastname: Huang
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
authors.forename: K T
authors.initials: KT
authors.lastname: Luh
mesh_terms: D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology*; D015373:Bacterial Typing Techniques; D002437:Cefazolin / Q000627:therapeutic use; D002506:Cephalexin / Q000627:therapeutic use; D002675:Child, Preschool; D002999:Clone Cells; D017714:Community-Acquired Infections; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy / Q000382:microbiology*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011803:Quinine / Q000031:analogs & derivatives* / Q000494:pharmacology; D019105:Random Amplified Polymorphic DNA Technique; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*
chemical_list: C017303:ethylhydrocupreine; D011803:Quinine; D002437:Cefazolin; D002506:Cephalexin