title: Effect of nifedipine administration (10 mg) on esophageal acid exposure time.
abstract: The effect of nifedipine administration (10 mg) on esophageal acid exposure time was investigated in 11 non-reflux esophagitis (non-RE) patients and 11 grade C (Los Angeles classification) reflux esophagitis (RE) patients. In each subject, esophageal pH monitoring was performed, with the subject in the supine position, preprandially (1 h) and 3-h postprandially after oral administration of a placebo in the morning and oral administration of nifedipine (10 mg) in the afternoon on the same day. In the non-RE patients, there was no difference in the esophageal acid exposure time between administration of the placebo and that of nifedipine. In patients with RE, the esophageal acid exposure time after the administration of nifedipine was significantly (P<0.05) longer than that after the placebo. In patients with severe RE, the severity of RE may worsen with nifedipine administration.
authors.affiliation: Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: K
authors.initials: K
authors.lastname: Iwakiri
authors.forename: T
authors.initials: T
authors.lastname: Sugiura
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004941:Esophagitis / Q000188:drug therapy*; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D004943:Esophagogastric Junction / Q000187:drug effects; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009543:Nifedipine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine