title: [Effectiveness of mesoglycan topical treatment of leg ulcers in subjects with chronic venous insufficiency].
abstract: BACKGROUND
  Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency.
  
  
  METHODS
  Forty patients, observed in our outpatients department, with venous leg ulcers have been randomized in two groups of twenty subjects, each treated with topical application of mesoglycan (1 or 2 vials/day) or vegetal stimulins and followed for two months, with controls after 15, 30 and 60 days.
  
  
  RESULTS
  At the end of the observation period, ulcer healing rate was 95% in the mesoglycan group, while a lower healing rate was obtained in the stimulins group (80%).
  
  
  CONCLUSIONS
  The present study confirms previous clinical experiences with mesoglycan and suggests its application in the topical treatment of venous ulcers.
authors.affiliation: Unità Operativa di Chirurgia Vascolare, Azienda Ospedaliera Civico Fatebenefratelli M. Ascoli, G. di Cristina, Palermo.
authors.forename: G
authors.initials: G
authors.lastname: La Marca
authors.forename: G
authors.initials: G
authors.lastname: Pumilia
authors.forename: A
authors.initials: A
authors.lastname: Martino
mesh_terms: D000287:Administration, Topical; D000368:Aged; D005260:Female; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014647:Varicose Ulcer / Q000188:drug therapy*
chemical_list: D006025:Glycosaminoglycans; C040617:mesoglycan