title: [Pediatric liver diseases].
abstract: Pediatric liver diseases usually manifest as jaundice, hepatomegaly, ascites or edema and can reflect a metabolic or nonmetabolic condition. In unconjugated hyperbilirubinemia, hemolysis can be distinguished from transient or inherited glucuronidation deficiencies. Jaundice with conjugated hyperbilirubinemia should suggest extrahepatic bile duct obstruction (requiring immediate surgery) or intrahepatic mechanical or metabolic cholestasis. Hepatomegaly or hepatocellular necrosis suggests diseases characterized by hepatocyte damage or overload. Appropriate investigations and a painstaking physical examination are essential to establish the diagnosis and to identify the cause, since immediate treatment is needed in some cases.
authors.affiliation: Service de Pédiatrie, Hôpital A. Béclère, BP 405, Clamart, France.
authors.forename: P
authors.initials: P
authors.lastname: Labrune
authors.forename: A
authors.initials: A
authors.lastname: Myara
authors.forename: F
authors.initials: F
authors.lastname: Imbert-Bismut
authors.forename: M F
authors.initials: MF
authors.lastname: Gerhardt
mesh_terms: D002779:Cholestasis; D006529:Hepatomegaly; D006801:Humans; D006932:Hyperbilirubinemia; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000628:therapy; D009336:Necrosis; D010372:Pediatrics