Strategies for transcriptional activation by steroid/nuclear receptors.
Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone-modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters. J. Cell. Biochem. Suppls. 32/33:103-109, 1999.
Freedman
L P
LP
Cell Biology Program Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. l-freedman@ski.mskcc.org
D000818:Animals; D006657:Histones / Q000378:metabolism; D006801:Humans; D008024:Ligands; D012319:RNA Polymerase II / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D015533:Transcriptional Activation / Q000235:genetics*
D006657:Histones; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D012319:RNA Polymerase II