POEMS syndrome with xanthomatous cells. Polyneuropathy Organomegaly Endocrinopathy M-protein Skin changes.
A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.
Chang
S E
SE
Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Choi
J H
JH
Sung
K J
KJ
Moon
K C
KC
Koh
J K
JK
Ro
J Y
JY
D000328:Adult; D001706:Biopsy; D006801:Humans; D008297:Male; D016878:POEMS Syndrome / Q000150:complications / Q000473:pathology*; D012867:Skin / Q000473:pathology / Q000648:ultrastructure; D014973:Xanthomatosis / Q000150:complications / Q000473:pathology*