title: A rare coding variant within the wolframin gene in bipolar and unipolar affective disorder cases.
abstract: A recent report has shown that Wolfram syndrome carriers (heterozygotes) are 26-fold more likely to require psychiatric hospitalization compared with non-carriers, and that Wolfram syndrome heterozygotes may constitute approximately 25% of individuals hospitalized with depression and suicide attempts. We analyzed a His611Arg polymorphism of the wolframin gene by the polymerase chain reaction (PCR) and HhaI restriction digestion, in 158 bipolar I and 163 unipolar major affective disorder cases, and 316 controls. Statistical analyses of allele or genotype frequencies do not support a major role for wolframin in affective disorder. HhaI restriction digestion and sequencing of PCR products from four affective disorder cases showed a heterozygous Ala559Thr change. The Ala559Thr variant was not detectable in 382 controls tested. Thus, the rare wolframin 559Thr allele deserves consideration as a risk allele for affective disorder.
authors.affiliation: Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Furlong
authors.forename: L W
authors.initials: LW
authors.lastname: Ho
authors.forename: J S
authors.initials: JS
authors.lastname: Rubinsztein
authors.forename: A
authors.initials: A
authors.lastname: Michael
authors.forename: C
authors.initials: C
authors.lastname: Walsh
authors.forename: E S
authors.initials: ES
authors.lastname: Paykel
authors.forename: D C
authors.initials: DC
authors.lastname: Rubinsztein
mesh_terms: D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D003062:Codon / Q000235:genetics; D003866:Depressive Disorder / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D019964:Mood Disorders / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D014929:Wolfram Syndrome / Q000235:genetics*
chemical_list: D003062:Codon; D008565:Membrane Proteins; C114987:wolframin protein