title: Hypoperfusion of inferior frontal brain regions in abstinent alcoholics: a pilot SPECT study.
abstract: OBJECTIVE
  This pilot study evaluated hypotheses concerning the relationship between cerebral hypoperfusion and residual deficits in the functioning of frontal brain systems in abstinent long-term alcoholics.
  
  
  METHODS
  The participants (N = 22) were 10 healthy, abstinent alcoholics (9 men) and 12 age-equivalent nonalcoholic controls (10 men). Cerebral blood flow was observed through the use of regionally specific computer-derived quantitative analysis of single photon emission computed tomography (SPECT) perfusion images. Measures of alcohol use, abstinence and neuropsychological functioning were also obtained to relate to SPECT findings.
  
  
  RESULTS
  A positive relationship was observed between perfusion levels in the left inferior frontal brain region and years of sobriety. Alcoholics with less than 4 years of sobriety had significantly reduced left inferior frontal perfusion compared with both nonalcoholic controls and alcoholics having longer periods of sobriety.
  
  
  CONCLUSIONS
  The findings support the hypothesis that frontal brain abnormalities in alcoholics may subside with extended abstinence.
authors.affiliation: Department of Psychiatry, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Gansler
authors.forename: G J
authors.initials: GJ
authors.lastname: Harris
authors.forename: M
authors.initials: M
authors.lastname: Oscar-Berman
authors.forename: C
authors.initials: C
authors.lastname: Streeter
authors.forename: R F
authors.initials: RF
authors.lastname: Lewis
authors.forename: I
authors.initials: I
authors.lastname: Ahmed
authors.forename: D
authors.initials: D
authors.lastname: Achong
mesh_terms: D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000704:Analysis of Variance; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012039:Regional Blood Flow; D012044:Regression Analysis; D013695:Temperance; D015899:Tomography, Emission-Computed, Single-Photon