title: Synthesis and opiate receptor binding properties of 17-methyl-6,7-dehydro-3,14-dihydroxy-4,5alpha-epoxy-6,7:4',5'-pyrimidin omorphinans.
abstract: A class of opioid receptor active derivatives of oxymorphone has been synthesized using a common enaminone intermediate. The derivatives have heterocyclic groups fused to the 6,7-positions of the morphinan system and all were synthesized in high yield. A pyrazolo derivative is an agonist for the mu and delta receptors and an antagonist for the kappa receptor.
authors.affiliation: College of Pharmacy, University of Illinois at Chicago, 60612-7231, USA.
authors.forename: W
authors.initials: W
authors.lastname: Xu
authors.forename: L F
authors.initials: LF
authors.lastname: Huang
authors.forename: L
authors.initials: L
authors.lastname: Bauer
authors.forename: H N
authors.initials: HN
authors.lastname: Bhargava
authors.forename: W J
authors.initials: WJ
authors.lastname: Dunn
mesh_terms: D009019:Morphinans / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D009292:Narcotic Antagonists; D011957:Receptors, Opioid / Q000819:agonists / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D009019:Morphinans; D009292:Narcotic Antagonists; D011957:Receptors, Opioid