title: Low-dose ethanol consumption allows strength recovery in chronic alcoholic myopathy.
abstract: Chronic skeletal myopathy may affect one third of chronic alcohol misusers. It is generally accepted that abstinence allows partial recovery, and that continued high-dose ethanol consumption progressively deteriorates muscle function. However, the effect of low-dose ethanol consumption in alcoholic myopathy has not been studied. We studied 58 chronic alcoholic male patients with biopsy-proven chronic alcoholic myopathy over 5 years. We evaluated ethanol intake, biochemical and nutritional parameters, and assessed muscle strength. Eighteen patients who remained abstinent showed marked improvement in muscle strength. As expected, the 19 patients who persisted in high-dose ethanol consumption further diminished in their muscle strength. In the 11 patients who maintained low-dose (</=60 g ethanol/day) 'controlled' drinking, muscle strength improved (p=0.003), despite no change in nutritional and exercise status. There is a dose-dependent recovery in muscle strength according to the degree of ethanol consumption, and moderate controlled drinking of up to 60 g ethanol/day still allows improvement in muscle strength.
authors.affiliation: Department of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, University of Barcelona, Spain. nicolas@medicina.ub.es
authors.forename: J
authors.initials: J
authors.lastname: Fernández-Solà
authors.forename: J M
authors.initials: JM
authors.lastname: Nicolás
authors.forename: E
authors.initials: E
authors.lastname: Sacanella
authors.forename: J
authors.initials: J
authors.lastname: Robert
authors.forename: M
authors.initials: M
authors.lastname: Cofan
authors.forename: R
authors.initials: R
authors.lastname: Estruch
authors.forename: A
authors.initials: A
authors.lastname: Urbano-Márquez
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects; D000437:Alcoholism / Q000150:complications / Q000473:pathology / Q000534:rehabilitation*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000534:rehabilitation*; D018482:Muscle, Skeletal / Q000503:physiopathology; D009135:Muscular Diseases / Q000188:drug therapy* / Q000209:etiology