title: Helicobacter pylori infection and gastric emptying in cirrhotic patients with symptoms of dyspepsia.
abstract: OBJECTIVE
  Chronic gastric Helicobacter pylori infection is common in patients with dyspeptic symptoms. The effect of H. pylori infection on gastric emptying, in cirrhotic patients with dyspeptic symptoms, has never been studied. Therefore, we investigated the incidence of H. pylori infection and its relationship with gastric emptying in cirrhotic patients with dyspepsia.
  
  
  METHODS
  A solid-phase gastric emptying study and 14C urea breath test were performed in 80 cirrhotic patients with dyspepsia. The severity of cirrhosis was assessed according to Child-Pugh's classification.
  
  
  RESULTS
  The overall incidence of delayed gastric emptying was 75%. Delayed gastric emptying incidences according to severity of cirrhosis were 71.4% for Child-A, 73.1% for Child-B, and 80.8% for Child-C. The differences were not significant. The incidence of H. pylori infection was 52.5% overall. H. pylori infection rates were 46.4% for Child-A, 42.3% for Child-B, and 69.2% for Child-C. Although there was a tendency for the infection rate to increase with the severity of liver cirrhosis, the difference was not significant. In addition, there were no significant differences in the incidences of H. pylori infection among patients with normal and delayed gastric emptying.
  
  
  CONCLUSIONS
  Delayed gastric emptying is common in cirrhotic patients with dyspepsia. However, the status of H. pylori infection does not seem to play a role in delayed gastric emptying in these patients.
authors.affiliation: Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan.
authors.forename: C S
authors.initials: CS
authors.lastname: Chang
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: H Z
authors.initials: HZ
authors.lastname: Yeh
authors.forename: H C
authors.initials: HC
authors.lastname: Lien
authors.forename: G H
authors.initials: GH
authors.lastname: Chen
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests; D002908:Chronic Disease; D004415:Dyspepsia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D016145:Endoscopy, Digestive System; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013624:Taiwan / Q000453:epidemiology; D014508:Urea / Q000032:analysis
chemical_list: D014508:Urea