The role of adhesion receptors in the pathogenesis of multiple myeloma.
There is now an improved understanding of the types of adhesion receptors present on normal and malignant plasma cells. This knowledge has been helpful in identifying plasma cells and in beginning to understand the pathogenesis of myeloma. Future research is needed to delineate the signaling pathways used by the plasma cell after the adhesion receptor binds to its ligands. This information should help in designing more effective therapy for this fatal disease.
Witzig
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Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. witzig@mayo.edu
D015415:Biomarkers; D001854:Bone Marrow Cells / Q000378:metabolism; D002448:Cell Adhesion; D006801:Humans; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000502:physiology*; D009101:Multiple Myeloma / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D019038:Platelet Glycoprotein GPIb-IX Complex
D015415:Biomarkers; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D019038:Platelet Glycoprotein GPIb-IX Complex; C094990:adhesion receptor