title: Levofloxacin in vitro activity and time-kill evaluation of Stenotrophomonas maltophilia clinical isolates.
abstract: The in vitro activity of levofloxacin and eight other antimicrobial agents against 60 clinical isolates of Stenotrophomonas maltophilia was determined by an agar dilution method using 10(4) and 10(6) cfu/spot inocula. At the lower inoculum, 85.0% of the isolates were susceptible to levofloxacin but only 58.3% were susceptible to ofloxacin; at the higher inoculum, 78.3% were susceptible to levofloxacin and 36.7% to ofloxacin. In time-kill studies, levofloxacin exerted bactericidal activity within 4 h. With ofloxacin and ciprofloxacin bacterial regrowth was observed after 8 h. Levofloxacin may represent an alternative drug in the treatment of infections caused by S. maltophilia.
authors.affiliation: Dipartimento di Scienze Microbiologiche, Università di Catania, via Androne 81, 95124 Catania, Italy. bonfigio@mbox.unict.it
authors.forename: G
authors.initials: G
authors.lastname: Bonfiglio
authors.forename: C
authors.initials: C
authors.lastname: Cascone
authors.forename: C
authors.initials: C
authors.lastname: Azzarelli
authors.forename: V
authors.initials: V
authors.lastname: Cafiso
authors.forename: F
authors.initials: F
authors.lastname: Marchetti
authors.forename: S
authors.initials: S
authors.lastname: Stefani
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D020615:Stenotrophomonas maltophilia / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin