[Features of the process of chromatin denaturation in leukemic tissue and murine spleen cells].
It was shown by the method of differential scanning microcalorimetry that an additional peak, at about 57 degrees C appears on heat absorption curves of the whole spleen tissue and cells of BalB/c mouse injected with Rausher virus. It is supposed that this peak is due to the melting of AT-rich regions of internucleosomal DNA in chromatin fibers of tumor cells, which results from the partial loss of proteins or the modification of H1 histone.
Monacelidze
D R
DR
Institute of Physics, Georgian Academy of Sciences, Tbilisi, Georgia.
Madzhagaladze
G V
GV
Bakradze
N G
NG
Birkaia
V G
VG
Sapozhnikova
N A
NA
Asatiani
N V
NV
D020856:AT Rich Sequence; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002843:Chromatin / Q000737:chemistry*; D004247:DNA / Q000378:metabolism; D007942:Leukemia, Experimental / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D011489:Protein Denaturation; D013154:Spleen / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D002843:Chromatin; D004247:DNA