FXII levels, FXIIa-like activities and kallikrein activities in normal subjects and patients undergoing cardiac surgery.
A new chromogenic peptide substrate assay kit was used to measure factor XII (FXII) levels in plasma samples from 115 male patients with heart disease awaiting cardiac surgery, 40 age-matched normal healthy male blood donors and 20 patients before, during and after cardiopulmonary bypass surgery (CPB). Kallikrein-like and FXIIa-like activities were also determined in the CPB patient group. FXII levels were significantly lower (p = 0.0049) in the heart disease patients awaiting surgery when compared with values for the healthy donors and 13 patients (11.3%) had FXII levels below 50% compared with 1 normal donor (2.5%). During CPB significant decreases in FXII levels and significant increases in FXIIa-like and kallikrein-like activities were found indicating activation of the FXII-plasma kallikrein pathway during CPB.
Wendel
H P
HP
Department of Surgery, Eberhard-Karls-University, Tuebingen, Germany. hp.wendel@uni-tuebingen.de
Jones
D W
DW
Gallimore
M J
MJ
D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass; D004789:Enzyme Activation; D005174:Factor XII / Q000378:metabolism*; D015956:Factor XIIa / Q000378:metabolism*; D006801:Humans; D007610:Kallikreins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care
D005174:Factor XII; D007610:Kallikreins; D015956:Factor XIIa