title: Cytogenetic investigation of thallium-poisoned people: pilot study.
abstract: Thirteen blood samples of thallium-poisoned people were cytogenetically investigated. The thallium concentration in blood varied from 25 to 2700 microg/L. The mean frequency of chromosomal aberrations in the poisoned group significantly exceeded our control level (7.08+/--2.19% and 2.03+/--0.25, p<.001). The rate of single fragments was significantly higher in poisoned group (7.77+/-2.68% and 1.59+/-0.23%, p<.001) while the frequencies of other types of chromosomal aberrations were similar in both groups. It is possible that thallium is an S-dependent clastogenic agent because the majority of the structural aberrations are of the chromatid type. Irrespective of mechanisms, damage to genetic material was revealed in thallium-poisoned people.
authors.affiliation: All Russian Centre of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg.
authors.forename: A
authors.initials: A
authors.lastname: Nikiforov
authors.forename: N
authors.initials: N
authors.lastname: Slozina
authors.forename: E
authors.initials: E
authors.lastname: Neronova
authors.forename: T
authors.initials: T
authors.lastname: Kharchenko
authors.forename: A
authors.initials: A
authors.lastname: Sosukin
authors.forename: S
authors.initials: S
authors.lastname: Scherbak
authors.forename: A
authors.initials: A
authors.lastname: Sarana
authors.forename: S
authors.initials: S
authors.lastname: Onikienko
mesh_terms: D000704:Analysis of Variance; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D015162:Micronucleus Tests; D010865:Pilot Projects; D011041:Poisoning / Q000097:blood; D013793:Thallium / Q000097:blood / Q000506:poisoning*
chemical_list: D013793:Thallium