[The influence of clomipramine-induced mania on rapid cycling affective disorder].
Rapid cycling affective disorder (RC) is defined as the presence of at least four affective episodes per year. We report two RC patients whose first manic episodes were considered to be induced by clomipramine. The first case, a 61-year-old female, suffered from RC after a manic episode with respect to oral administration of clomipramine. The second case, a 45-year-old female, showed cycle acceleration after a manic episode regarding intravenous drip infusion treatment with clomipramine. They had no manic or hypomanic episodes before the administration of clomipramine. We discuss the possible induction and worsening of RC through clomipramine-induced mania.
Soeda
S
S
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Terao
T
T
Nakamura
J
J
D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000139:chemically induced*; D002997:Clomipramine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged
D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine