Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation.
Toxoplasma gondii infection reactivation predominantly occurs among patients after allogeneic haematopoietic stem cell transplantation. Mostly, reactivation occurs during first 3 months after transplant, especially when risk factors are present. We report a case of late cerebral toxoplasmosis reactivation, which was probably triggered by a brief course of corticosteroids, administered for chronic graft-versus-host disease (cGVHD). In the presence of risk factors, such as cGVHD, prophylactic treatment for toxoplasmosis should be reinstituted; Trimethoprim-sulfamethoxasole most probably prevented earlier reactivation of toxoplasmosis in our patient.
Zver
S
S
Department of Haematology, University Medical Centre Ljubljana, Slovenija.
Cernelc
P
P
Mlakar
U
U
Pretnar
J
J
D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000818:Animals; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D013420:Sulfamethoxazole / Q000627:therapeutic use; D016781:Toxoplasmosis, Cerebral / Q000097:blood / Q000209:etiology*; D014184:Transplantation, Homologous / Q000009:adverse effects; D014295:Trimethoprim / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D014295:Trimethoprim; D013420:Sulfamethoxazole