title: Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.
abstract: High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.
authors.affiliation: Servicio de Medicina Interna 1, Clinica Puerta de Hierro, Universidad Autonoma de Madrid, and Servicio de Microbiologia, Hospital General Gregorio Maranon, Madrid, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: de Quiros
authors.forename: W L
authors.initials: WL
authors.lastname: Shupert
authors.forename: A C
authors.initials: AC
authors.lastname: McNeil
authors.forename: J C
authors.initials: JC
authors.lastname: Gea-Banacloche
authors.forename: M
authors.initials: M
authors.lastname: Flanigan
authors.forename: A
authors.initials: A
authors.lastname: Savage
authors.forename: L
authors.initials: L
authors.lastname: Martino
authors.forename: E E
authors.initials: EE
authors.lastname: Weiskopf
authors.forename: H
authors.initials: H
authors.lastname: Imamichi
authors.forename: Y M
authors.initials: YM
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Adelsburger
authors.forename: R
authors.initials: R
authors.lastname: Stevens
authors.forename: P M
authors.initials: PM
authors.lastname: Murphy
authors.forename: P A
authors.initials: PA
authors.lastname: Zimmerman
authors.forename: C W
authors.initials: CW
authors.lastname: Hallahan
authors.forename: R T
authors.initials: RT
authors.lastname: Davey
authors.forename: M
authors.initials: M
authors.lastname: Connors
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D017690:Cell Transplantation; D018450:Disease Progression; D016655:HIV Core Protein p24 / Q000276:immunology*; D015658:HIV Infections / Q000097:blood / Q000276:immunology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000637:transplantation / Q000821:virology; D008297:Male; D051379:Mice; D016513:Mice, SCID; D014779:Virus Replication
chemical_list: D016655:HIV Core Protein p24