title: Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo.
abstract: We have previously found that alcohol extract of Crocus sativus L. (CSE), commonly known as saffron, prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP). In the present study, CSE (250 mg/kg, p.o.) was also effective in preventing acetaldehyde-induced inhibition of LTP in the dentate gyrus of anesthetized rats. These results suggest that CSE can prevent aversive effects induced by ethanol and its metabolite acetaldehyde.
authors.affiliation: Faculty of Pharmaceutical Sciences, Department of Chemical Pharmacology, University of Tokyo, Japan. kazuhoab@mo1.f.u-tokyo.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Abe
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Shoyama
authors.forename: H
authors.initials: H
authors.lastname: Saito
mesh_terms: D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects*; D019668:Liliaceae; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000079:Acetaldehyde