Effects of positive end-expiratory pressure ventilation on cerebral venous pressure with head elevation in dogs.
Mechanical ventilation with positive end-expiratory pressure (PEEP) may prevent venous air embolism in the sitting position because cerebral venous pressure (Pcev) could be increased by the PEEP-induced increase in right atrial pressure (Pra). Whereas it is clear that there is a linear transmission of the PEEP-induced increase in Pra to Pcev while the dog is in the prone position, the mechanism of the transmission with the dog in the head-elevated position is unclear. We tested the hypothesis that a Starling resistor-type mechanism exists in the jugular veins when the head is elevated. In one group of dogs, increasing PEEP linearly increased Pcev with the dog in the prone position (head at heart level, slope = 0.851) but did not increase Pcev when the head was elevated. In another group of dogs, an external chest binder was used to produce a larger PEEP-induced increase in Pra. Further increasing Pra increased Pcev only after Pra exceeded a pressure of 19 mmHg (break pressure). This sharp inflection in the upstream (Pcev)-downstream (Pra) relationship suggests that this may be caused by a Starling resistor-type mechanism. We conclude that jugular venous collapse serves as a significant resistance in the transmission of Pra to Pcev in the head-elevated position.
Toung
T J
TJ
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7834, USA.
Aizawa
H
H
Traystman
R J
RJ
D000818:Animals; D016275:Atrial Function; D001794:Blood Pressure / Q000502:physiology*; D002550:Cerebral Veins / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure; D004285:Dogs; D006257:Head; D007427:Intracranial Pressure; D007601:Jugular Veins / Q000502:physiology; D008297:Male; D011175:Positive-Pressure Respiration; D011187:Posture / Q000502:physiology*