title: The central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS).
abstract: Uncovering primary target antigens in multiple sclerosis (MS) is of major significance for understanding the etiology and pathophysiology of the disease, and for designing immunospecific therapy. In this study, a synthetic peptide representing a predicted T cell epitope on myelin oligodendrocytic basic protein (MOBP) was found to be encephalitogenic in C3H.SW mice, inducing experimental autoimmune encephalomyelitis with an abrupt onset. Two separate preliminary studies with MOBP peptides indicated that autoreactivity to MOBP occurs in MS. These data strongly suggest that MOBP is a highly relevant target in MS and further point to the complexity of antigen specificities in MS.
authors.affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.
authors.forename: J F
authors.initials: JF
authors.lastname: Kaye
authors.forename: N
authors.initials: N
authors.lastname: Kerlero de Rosbo
authors.forename: I
authors.initials: I
authors.lastname: Mendel
authors.forename: S
authors.initials: S
authors.lastname: Flechter
authors.forename: M
authors.initials: M
authors.lastname: Hoffman
authors.forename: I
authors.initials: I
authors.lastname: Yust
authors.forename: A
authors.initials: A
authors.lastname: Ben-Nun
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D015551:Autoimmunity / Q000502:physiology; D002460:Cell Line; D003711:Demyelinating Diseases / Q000276:immunology / Q000503:physiopathology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000503:physiopathology; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000276:immunology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000235:genetics / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000939:Epitopes; C560487:MOBP protein, human; C571326:MOG protein, human; C560488:Mobp protein, mouse; C571327:Mog protein, mouse; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D010446:Peptide Fragments