Antimicrobial effect of camphorated chloroxylenol (ED 84) in the treatment of infected root canals.
During and after chemomechanical preparation, particularly before the definitive filling of an infected root canal, a temporary intracanal dressing with an antimicrobial activity is generally indicated. Therefore, the aim of this study was to investigate the antimicrobial effect of ED 84, a liquid root canal disinfectant containing chloroxylenol (10%) and camphor (15%), against selected test organisms (Staphylococcus aureus, Streptococcus faecalis, Escherichia coli, and Candida albicans) both in vitro and under clinical conditions, using extracted teeth. With a contact time of 180 min between undiluted ED 84 and the four bacterial suspensions in the canal, there was a 2 to 3 log reduction in the number of organisms. Under in vitro conditions, the reduction was even greater than 3 logs. When using a liquid medication as a temporary root canal dressing for a duration of approximately 2 days, ED 84 can definitely be used.
Schäfer
E
E
Poliklinik für Zahnerhaltung, Westfälische Wilhelms-Universität Münster, Germany.
Bössmann
K
K
D000891:Anti-Infective Agents, Local / Q000494:pharmacology* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D002164:Camphor / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects; D002733:Chlorophenols / Q000494:pharmacology* / Q000627:therapeutic use; D015169:Colony Count, Microbial; D003786:Dental Pulp Cavity / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D012388:Root Canal Irrigants / Q000494:pharmacology* / Q000627:therapeutic use; D013211:Staphylococcus aureus / Q000187:drug effects; D014992:Xylenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D000891:Anti-Infective Agents, Local; D002733:Chlorophenols; C091831:ED 84; D012388:Root Canal Irrigants; D014992:Xylenes; C007027:chloroxylenol; D002164:Camphor