title: The neural correlates of updating information in verbal working memory.
abstract: The aim of the present study was to re-examine cerebral areas subserving the updating function of the central executive with a running span task requiring subjects to watch strings of consonants of unknown length and then to recall serially a specific number of recent items. In order to dissociate more precisely the updating process from the storage function, a four-item instead of a six-item memory load was used, contrary to our previous study (Salmon et al., 1996). In addition, a serial recall procedure was preferred to a recognition procedure in order to suppress the use of visuospatial strategies. The most significant increase of rCBF occurred in the left frontopolar cortex (Brodmann's area 10), spreading to the left middle frontal (Brodmann's area 46). Results suggest that frontopolar activation underlies an updating process in working memory.
authors.affiliation: Neuropsychology Unit, University of Liège, Belgium. mvanderlinden@ulg.ac.be
authors.forename: M
authors.initials: M
authors.lastname: Van der Linden
authors.forename: F
authors.initials: F
authors.lastname: Collette
authors.forename: E
authors.initials: E
authors.lastname: Salmon
authors.forename: G
authors.initials: G
authors.lastname: Delfiore
authors.forename: C
authors.initials: C
authors.lastname: Degueldre
authors.forename: A
authors.initials: A
authors.lastname: Luxen
authors.forename: G
authors.initials: G
authors.lastname: Franck
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D014055:Tomography, Emission-Computed