[Familial combined hyperlipidemia].
Familial combined hyperlipidemia (FCHL) is the most common genetic hyperlipidemia of unknown etiology. FCHL is characterized by a variable phenotype of both hypercholesterolemia and hypertriglyceridemia in proband and family members. While, the genetic basis for FCHL has not been characterized, recently, linkage analysis of Finnish FCHL family indicated major gene locus on chromosome 1q21-23. We review recent progress of genetics of FCHL.
Sasaki
J
J
Department of Internal Medicine, Fukuoka University School of Medicine.
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000235:genetics*; D051379:Mice