title: Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery.
abstract: With pressure on pharmaceutical companies to reduce time-to-market and improve the success rate of new drug candidates, higher-throughput pharmacokinetic (HTPK) support has become an integral part of many drug discovery programmes. This report details the amalgamation of robotics, new sample preparation technologies and highly sensitive and selective mass spectrometric detection systems to deliver the promise of HTPK. A historical perspective on automated bioanalysis with the current approaches and future prospects for the discipline are described.
authors.affiliation: Department of Medicinal Chemistry (Drug Metabolism Section), Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow CM20 2QR UK.
authors.initials: AP
authors.lastname: Watt
authors.initials: I
authors.lastname: Morrison
authors.initials: DC
authors.lastname: Evans