Errors in the spleen-blood partition coefficient for water in C15O2 steady-state PET.
The aim of this study was to clarify if the value of 0.93, determined for patients with normal livers, is useful as a pathological spleen-blood partition coefficient for water when the splenic blood flow is quantified by the C15O2 steady-state method. A steady-state PET scan with continuous inhalation of C15O2 and a dynamic PET scan with a H(2)15O bolus injection were performed. From 157 patients, 392 slices were chosen as having planes that encompassed the spleen and provided regions of interest with full signal imaging. A comparison of the results of the steady-state and dynamic methods was performed. When 0.93 was adopted as the spleen-blood partition coefficient for water, an error of about 25% was seen in the splenic blood flow of patients with cirrhosis. When measuring splenic blood flow, the H(2)15O dynamic method is necessary. However, a rough estimate of splenic blood flow is possible by the C15O2 PET steady-state method, if this error is known.
Taniguchi
H
H
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan. taniguchi@1surg.kpu-m.ac.jp
Oguro
A
A
Koyama
H
H
Masuyama
M
M
Yamaguchi
A
A
Kunishima
S
S
Koh
T
T
Yamagishi
H
H
D000328:Adult; D000368:Aged; D002199:Capillary Permeability; D002245:Carbon Dioxide; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging*; D006801:Humans; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes; D012039:Regional Blood Flow; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
D010104:Oxygen Radioisotopes; D002245:Carbon Dioxide