Transfusion associated graft versus host disease in immunocompetent patients. Report of two cases.
Transfusion graft versus host disease (TGVHD) in immunocompetent patients is a recently recognized disease, reported mainly after open heart surgery, and almost always fatal. We report two cases of TGVHD in immunocompetent patients after open-heart surgery. The disease is characterized by the occurrence of fever, skin rash, liver failure and pancytopenia. Preventive measures include exclusion of first- and second-degree relatives as blood donors, and/or irradiation of blood to be transfused.
Gebran
N
N
Saint-Georges Hospital, Beirut (SGH), Lebanese University School of Medicine, Lebanon.
Aoun
J P
JP
Aftimos
G
G
Debahy
N
N
Chamseddine
N
N
Hakimeh
N
N
Bahous
J
J
D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D001782:Blood Donors; D001026:Coronary Artery Bypass; D017809:Fatal Outcome; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000235:genetics / Q000276:immunology*; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007121:Immunocompetence / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000276:immunology*; D012307:Risk Factors; D065227:Transfusion Reaction