title: Avascular necrosis of bone in human immunodeficiency virus infected patients.
abstract: The objective of this article was to delineate the causes of avascular necrosis (AVN) in patients with human immunodeficiency virus (HIV). HIV-infected patients with pain in large joints were prospectively screened. Patients had radiographs and magnetic resonance imaging of their affected joints. Serum lipids, anticardiolipin antibody levels (IgG, IgM), and hemoglobin electrophoresis were performed on all patients who had radiographic studies. Medical records were screened for factors known to predispose for AVN. Eight patients completed the protocol, and five patients had AVN in seven joints. No common laboratory abnormality was identified in the patients with AVN. All of the patients with AVN had a history of steroid use; four of five patients having taken steroids for HIV-related diseases. The cause of AVN does not appear to be directly related to the disease, but to steroid treatment for manifestations of the disease.
authors.affiliation: Department of Radiology, University of Medicine & Dentistry of New Jersey, C-320 University Hospital, Newark 07103-2426, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Blacksin
authors.forename: P C
authors.initials: PC
authors.lastname: Kloser
authors.forename: J
authors.initials: J
authors.lastname: Simon
mesh_terms: D000328:Adult; D001175:Arthrography; D003937:Diagnosis, Differential; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis; D006621:Hip Joint / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000175:diagnosis / Q000209:etiology*; D011446:Prospective Studies; D012785:Shoulder Joint / Q000000981:diagnostic imaging / Q000473:pathology*