title: Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study.
abstract: BACKGROUND
  Patients with prostate cancer and their physicians need knowledge of treatment options and their potential complications, but limited data on complications are available in unselected population-based cohorts of patients.
  
  
  OBJECTIVE
  To measure changes in urinary and sexual function in men who have undergone radical prostatectomy for clinically localized prostate cancer.
  
  
  METHODS
  The Prostate Cancer Outcomes Study, a population-based longitudinal cohort study with up to 24 months of follow-up.
  
  
  METHODS
  Population-based cancer registries in 6 geographic regions of the United States.
  
  
  METHODS
  A total of 1291 black, white, and Hispanic men aged 39 to 79 years who were diagnosed as having primary prostate cancer between October 1, 1994, and October 31, 1995, and who underwent radical prostatectomy within 6 months of diagnosis for clinically localized disease.
  
  
  METHODS
  Distribution of and change in urinary and sexual function measures reported by patients at baseline and 6, 12, and 24 months after diagnosis.
  
  
  RESULTS
  At 18 or more months following radical prostatectomy, 8.4% of men were incontinent and 59.9% were impotent. Among men who were potent before surgery, the proportion of men reporting impotence at 18 or more months after surgery varied according to whether the procedure was nerve sparing (65.6% of non-nerve-sparing, 58.6% of unilateral, and 56.0% of bilateral nerve-sparing). At 18 or more months after surgery, 41.9% reported that their sexual performance was a moderate-to-large problem. Both sexual and urinary function varied by age (39.0% of men aged <60 years vs 15.3 %-21.7% of older men were potent at > or =18 months [P<.001]; 13.8% of men aged 75-79 years vs 0.7%-3.6% of younger men experienced the highest level of incontinence at > or =18 months [P = .03]), and sexual function also varied by race (38.4% of black men reported firm erections at > or =18 months vs 25.9% of Hispanic and 21.3% of white men; P = .001).
  
  
  CONCLUSIONS
  Our study suggests that radical prostatectomy is associated with significant erectile dysfunction and some decline in urinary function. These results may be particularly helpful to community-based physicians and their patients with prostate cancer who face difficult treatment decisions.
authors.affiliation: Fred Hutchinson Cancer Research Center, Department of Epidemiology, University of Washington, Seattle 98109-1024, USA. jstanfor@fhcrc.org
authors.forename: J L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Z
authors.initials: Z
authors.lastname: Feng
authors.forename: A S
authors.initials: AS
authors.lastname: Hamilton
authors.forename: F D
authors.initials: FD
authors.lastname: Gilliland
authors.forename: R A
authors.initials: RA
authors.lastname: Stephenson
authors.forename: J W
authors.initials: JW
authors.lastname: Eley
authors.forename: P C
authors.initials: PC
authors.lastname: Albertsen
authors.forename: L C
authors.initials: LC
authors.lastname: Harlan
authors.forename: A L
authors.initials: AL
authors.lastname: Potosky
mesh_terms: D000328:Adult; D000368:Aged; D003625:Data Collection; D007172:Erectile Dysfunction / Q000453:epidemiology / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011468:Prostatectomy / Q000009:adverse effects*; D011471:Prostatic Neoplasms / Q000601:surgery*; D012044:Regression Analysis; D012723:Sex; D014549:Urinary Incontinence / Q000453:epidemiology / Q000209:etiology*; D014551:Urinary Tract