title: Effect of creatine loading on neuromuscular fatigue threshold.
abstract: The purpose of this investigation was to determine the effect of creatine (Cr) loading on the onset of neuromuscular fatigue by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at the fatigue threshold (PWC(FT)) test. Using a double-blind random design, 15 women athletes [mean age 19.0 +/- 2.0 (SD) yr] from the university crew team received a placebo (n = 8; 20 g glucose) or Cr (n = 7; 5 g Cr monohydrate + 20 g glucose) four times per day for 5 consecutive days. Analysis of covariance was used to analyze the data (covaried for presupplementation PWC(FT) values). The adjusted mean postsupplementation PWC(FT) value for the Cr group (mean = 186 W) was significantly (P < 0.05) higher than that of the placebo group (mean = 155 W). These findings suggest that Cr loading may delay the onset of neuromuscular fatigue.
authors.affiliation: Exercise Science Department, Creighton University, Omaha, Nebraska 68178, USA. jrstout@creighton.edu
authors.forename: J
authors.initials: J
authors.lastname: Stout
authors.forename: J
authors.initials: J
authors.lastname: Eckerson
authors.forename: K
authors.initials: K
authors.lastname: Ebersole
authors.forename: G
authors.initials: G
authors.lastname: Moore
authors.forename: S
authors.initials: S
authors.lastname: Perry
authors.forename: T
authors.initials: T
authors.lastname: Housh
authors.forename: A
authors.initials: A
authors.lastname: Bull
authors.forename: J
authors.initials: J
authors.lastname: Cramer
authors.forename: A
authors.initials: A
authors.lastname: Batheja
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001827:Body Height; D001835:Body Weight; D003401:Creatine / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D004576:Electromyography; D005260:Female; D006801:Humans; D018763:Muscle Fatigue / Q000187:drug effects* / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011897:Random Allocation; D013997:Time Factors
chemical_list: D003401:Creatine