title: Medullo adrenal response to lesion of anterodorsal thalamic nuclei in rats.
abstract: Anterodorsal thalamic nuclei (ADTN) exert an inhibitory influence on hypophyso-adrenal system (HAS) in rats. With the purpose of evaluating if ADTN are also involved in the control of medullo adrenal activity, experiments were conducted on female rats with bilateral lesion of these nuclei. Thirty days after lesion, plasma epinephrine (E) concentration in lesioned rats was higher than that in sham-lesioned control group (P < 0.02). Meanwhile, adrenal E content was significantly lower in lesioned animals than that found in the control group (P < 0.005). Plasma norepinephrine (NE) values in lesioned rats were not significantly different from those in the control ones, however, there was a significant decrease in adrenal NE when compared to the control one (P < 0.02). Basal values of plasma ACTH and plasma and adrenal corticosterone (C) were signicantly higher than those in sham lesioned rats (P < 0.05; P < 0. 001; P < 0.001 respectively). These findings demonstrate that the ADTN in rats are involved in the regulation of both cortico and medullo adrenal activity.
authors.affiliation: Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacionalde Córdoba, Argentina. martasuarez@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Suárez
authors.forename: N
authors.initials: N
authors.lastname: Perassi
authors.forename: L
authors.initials: L
authors.lastname: Franchione
mesh_terms: D000313:Adrenal Medulla / Q000378:metabolism / Q000503:physiopathology*; D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D005260:Female; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013787:Thalamic Nuclei / Q000293:injuries / Q000503:physiopathology*
chemical_list: D000324:Adrenocorticotropic Hormone; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine