title: [Analysis of prevalent Orientia tsutsugamushi in Aichi Prefecture].
abstract: Orientia tsutsugamushi was isolated from one of 8 patients' sera in Aichi Prefecture, and was identified to have the same antigenicity with the KN-2 strain (KN-2 like) based on the reactivity with 13 types of strain-specific or cross-reactive monoclonal antibodies to Karp, Gilliam, and Kato strains. Four isolates from 4 unfed larvae and adult of Leptotrombidium pallidum were also classified as the KN-3 like strains. Using indirect immunofluorescence, sera from 20 patients with tsutsugamushi disease were tested for reactivity with KN-1, KN-2, KN-3, and GJ-1 strains, isolated from patients in Gifu Prefecture. Fifteen sera showed the highest titer against KN-2 strain in Immunogloburin M (IgM). Of the other 5, three were higher for KN-3 strain in IgM, and two were KN-1 or GJ-1, respectively. These results suggested that KN-2 like strains were prevalent in the region where the number of patients has been ranked the highest in Aichi Prefecture. KN-1, KN-3, and GJ-1 like strains were also existed in this area. KN-3 like strain was likely to be distributed in another area. Aichi Prefecture.
authors.affiliation: Department of Microbiology, Aichi Prefectural Institute of Public Health.
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Morishita
authors.forename: H
authors.initials: H
authors.lastname: Tsuzuki
authors.forename: K
authors.initials: K
authors.lastname: Sakae
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Kadosaka
authors.forename: S
authors.initials: S
authors.lastname: Kasuya
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D003429:Cross Reactions; D006801:Humans; D007564:Japan / Q000453:epidemiology; D051379:Mice; D012285:Orientia tsutsugamushi / Q000276:immunology / Q000302:isolation & purification*; D015995:Prevalence; D012612:Scrub Typhus / Q000453:epidemiology / Q000276:immunology; D016036:Seroepidemiologic Studies
chemical_list: D000907:Antibodies, Bacterial