title: Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA.
abstract: OBJECTIVE
  To quantify MRI enhancement characteristics of normal and abnormal prostatic tissues and to correlate these with tumour stage, histological grade and tumour markers.
  
  
  METHODS
  Quantitative gradient recalled echo MR images were obtained following bolus injection of gadopentetate dimeglumine in 48 patients with prostate cancer. Turbo spin-echo T2-weighted images at the same anatomical position were reviewed for the presence of tumours (45 regions), normal peripheral zone (33 regions), and normal appearing central gland (30 regions). Time-signal intensity parameters (onset time, mean gradient and maximal amplitude of enhancement and wash-out score) and modelling parameters (permeability surface area product, lesion leakage space and maximum gadolinium concentration) were correlated with tumour stage, histological grade (Gleason score) and serum prostatic specific antigen (PSA) levels.
  
  
  RESULTS
  Significant differences were noted between peripheral zone and tumour with respect to signal intensity and modelling parameters (P = 0.0001), except onset time. No differences between central gland and tumour enhancement values were seen. There was weak correlation between MRI tumour stage and tumour vascular permeability (r(2) = 12%; P = 0.02) and maximum tumour gadolinium concentration (r(2) = 14%; P = 0.015). However, no significant correlations were seen with Gleason score or PSA levels.
  
  
  CONCLUSIONS
  Quantification of MR contrast enhancement characteristics allows tissue discrimination in prostate cancer consistent with known variations in microvessel density estimates.
authors.affiliation: Academic Department of Radiology, Institute of Cancer Research, The Royal Marsden NHS Trust, Downs Road, Sutton, Surrey, SM2 5PT, U.K.
authors.forename: A R
authors.initials: AR
authors.lastname: Padhani
authors.forename: C J
authors.initials: CJ
authors.lastname: Gapinski
authors.forename: D A
authors.initials: DA
authors.lastname: Macvicar
authors.forename: G J
authors.initials: GJ
authors.lastname: Parker
authors.forename: J
authors.initials: J
authors.lastname: Suckling
authors.forename: P B
authors.initials: PB
authors.lastname: Revell
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: D P
authors.initials: DP
authors.lastname: Dearnaley
authors.forename: J E
authors.initials: JE
authors.lastname: Husband
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media; D017430:Prostate-Specific Antigen