title: Unusual presentation of a Merkel cell carcinoma.
abstract: Merkel cell carcinoma (MCC) is an uncommon, potentially lethal, cutaneous tumor that mainly occurs in sun-exposed skin of the head and neck area of the elderly. We report a case of MCC presenting as a 2-mm crusted erosion on the nose of an elderly patient, the smallest MCC reported thus far in the literature. The optimal management of MCC has not been clearly established. In view of its high local recurrence rate, predilection to metastasis, and significant mortality, aggressive treatment has been advocated. Identification of this tumor at such a small size posed a management dilemma because of lack of prospective treatment data involving biologic markers of prognostic significance for MCC.
authors.affiliation: University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA.
authors.forename: T G
authors.initials: TG
authors.lastname: Chiarelli
authors.forename: J M
authors.initials: JM
authors.lastname: Grant-Kels
authors.forename: J R
authors.initials: JR
authors.lastname: Sporn
authors.forename: W N
authors.initials: WN
authors.lastname: Rezuke
authors.forename: J D
authors.initials: JD
authors.lastname: Whalen
mesh_terms: D000368:Aged; D001706:Biopsy; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis* / Q000601:surgery; D062109:Dermatologic Surgical Procedures; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015580:Mohs Surgery; D009297:Nasal Mucosa / Q000378:metabolism; D009666:Nose / Q000473:pathology / Q000601:surgery; D009669:Nose Neoplasms / Q000175:diagnosis* / Q000601:surgery; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000601:surgery