title: Depressant and anticonvulsant properties of the root decoction of Afrormosia laxiflora (Leguminosae).
abstract: The lyophilized root decoction of Afrormosia laxiflora (Leguminosae), claimed to be beneficial in epilepsy and psychosis, was screened for depressant and anticonvulsant activities using in vivo models. The root decoction, 150-300 mg/kg, showed significant inhibition of motor activity in mice, indicating depressant actions. Similarly, doses of 150-300 mg/kg of this extract significantly diminished the duration of convulsive symptoms, and increased the seizure latency, in both picrotoxin- and electroshock-induced seizures when compared with controls. The results suggest possible beneficial effects of the plant's root and also offer a rational explanation for its folklore usage in epilepsy and related disorders.
authors.affiliation: Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.
authors.forename: A K
authors.initials: AK
authors.lastname: Haruna
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D010852:Picrotoxin / Q000633:toxicity; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D010852:Picrotoxin