title: [Differential orthostatic dysregulation disorders diagnosis].
abstract: Orthostatic circulatory disorders are frequently the cause of orthostatic intolerance, syncope or dangerous falls. A sufficient therapy should be based on a differential diagnosis by means of an active standing test or a tilt-table test. Three typical pathological reactions of blood pressure and heart rate can be differentiated. The hypoadrenergic orthostatic hypotension is characterised by an immediate drop in blood pressure (systolic drop > 20 mmHg below base line within 3 min) with or without compensatory tachycardia. It is caused by peripheral or central sympathetic dysfunction. Tachycardia (> 30 beats per minute above base line within 10 min) without significant blood pressure drop but with a fall of cerebral blood flow indicates a postural tachycardia syndrome. In general, there is no further somatic dysfunction. Increased venous pooling is thought to be the assumed pathomechanism. A reflex mechanism evokes the neurocardiogenic syncope after a certain time of standing: sympathetic inhibition yields a strong blood pressure drop and vagal activation bradycardia. Proved therapies include use of the mineralocorticoide fludrocortison (hypoadrenergic orthostatic hypotension), of the alpha-agonist midodrin (postural tachycardia syndrome) and of beta-blockers (neurocardiogenic syncope).
authors.affiliation: Autonomes Labor, Neurologische Klinik mit Klinischer Neurophysiologie, Krupp Krankenhaus, Essen.
authors.forename: R R
authors.initials: RR
authors.lastname: Diehl
authors.forename: D
authors.initials: D
authors.lastname: Linden
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D007024:Hypotension, Orthostatic / Q000175:diagnosis* / Q000209:etiology; D019462:Syncope, Vasovagal / Q000175:diagnosis* / Q000209:etiology; D018667:Tilt-Table Test