Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases.
Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.
Tak
P P
PP
Division of Clinical Immunology and Rheumatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands. P.P.Tak@amc.uva.nl
Zvaifler
N J
NJ
Green
D R
DR
Firestein
G S
GS
D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002061:Bursa, Synovial / Q000166:cytology / Q000378:metabolism; D016158:Genes, p53 / Q000187:drug effects / Q000235:genetics; D006801:Humans; D009154:Mutation; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53