title: Electrolyte vs. glucose-electrolyte isotonic solutions for oral rehydration therapy in horses.
abstract: An isotonic electrolyte solution with a composition similar to equine sweat was compared to an isotonic glucose-glycine-electrolyte solution for oral rehydration therapy in exercising horses. Ten horses were dehydrated by using frusemide and allocated randomly to receive 4 different oral solutions: isotonic sweat-like electrolyte solution, half-strength hypotonic electrolyte solution, isotonic glucose-glycine-electrolyte solution, and plain water. Solutions were given by nasogastric tube using the same volume as the bodyweight lost by each horse. Blood samples were collected before and throughout 6 h of the rehydration period. Results showed that all solutions recovered pre-frusemide values of packed cell volume (PCV) and total plasma protein (TP) in a similar fashion. No changes for Na+ values were observed during the rehydration period when the isotonic sweat-like solution was used. However, a significant hyponatraemia was induced throughout rehydration when the other 3 solutions were given, especially when hypotonic solution and water were used. Osmolality values did not change when both isotonic solutions were administered; but a significant hypotonicity was observed when hypotonic solution and water were given. When the isotonic sweat-like solution was used, plasma Cl-, K+ and creatinine values recovered to premedication values significantly faster than the other 3 solutions. In conclusion, the isotonic sweat-like electrolyte was the best solution because it restored rapidly the fluid and plasma electrolyte imbalances. In contrast, the isotonic glucose-glycine-electrolyte solution impaired the plasma electrolyte imbalances.
authors.affiliation: Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Monreal
authors.forename: N
authors.initials: N
authors.lastname: Garzón
authors.forename: Y
authors.initials: Y
authors.lastname: Espada
authors.forename: R
authors.initials: R
authors.lastname: Ruíz-Gopegui
authors.forename: J
authors.initials: J
authors.lastname: Homedes
mesh_terms: D000818:Animals; D003681:Dehydration / Q000139:chemically induced / Q000662:veterinary; D004232:Diuretics; D004573:Electrolytes / Q000627:therapeutic use*; D005260:Female; D005440:Fluid Therapy / Q000662:veterinary*; D005665:Furosemide; D005947:Glucose / Q000627:therapeutic use*; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007552:Isotonic Solutions; D008297:Male; D013178:Sports Medicine; D013542:Sweat
chemical_list: D004232:Diuretics; D004573:Electrolytes; D007552:Isotonic Solutions; D005665:Furosemide; D005947:Glucose