Cerebral blood flow and metabolic changes produced by repetitive magnetic brain stimulation.
We evaluated cerebral variation in oxyhemoglobin, deoxyhemoglobin, and cytochrome oxidase before and after transcranial magnetic and electrical stimulation in ten healthy volunteers using near-infrared spectroscopy. Immediately after magnetic but not after electric stimulation a significant increase in oxyhemoglobin and a decrease in cytochrome oxidase were observed (P < 0.05). Our data suggest that repetitive transcranial magnetic stimulation induces metabolic activation of the cerebral cortex together with an increase in cerebral blood flow.
Oliviero
A
A
Istituto di Neurologia, Università Cattolica, Rome, Italy.
Di Lazzaro
V
V
Piazza
O
O
Profice
P
P
Pennisi
M A
MA
Della Corte
F
F
Tonali
P
P
D000328:Adult; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004558:Electric Stimulation; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010108:Oxyhemoglobins / Q000378:metabolism; D010812:Physical Stimulation / Q000379:methods; D019265:Spectroscopy, Near-Infrared
D010108:Oxyhemoglobins; D003576:Electron Transport Complex IV