title: Myocardial mechanical restitution and potentiation partly underlie alternans decay of postextrasystolic potentiation: simulation.
abstract: We have reported that the postextrasystolic potentiation (PESP) decays in alternans or monotonically, respectively, depending on whether the first postextrasystolic beat interval has a compensatory pause or not, in the canine left ventricle. To get better mechanistic insight into the alternans PESP decay, we hypothesized that the myocardial mechanical restitution and potentiation could partly account for both types of PESP decay. To test this hypothesis, we simulated PESP decay on a computer using a documented equation combining myocardial mechanical restitution and potentiation. We changed the first postextrasystolic beat interval after a fixed extrasystolic beat interval without changing regular and other postextrasystolic beat intervals. The simulated PESP decayed in alternans or monotonically as a function only of the first postextrasystolic beat interval. Thus, the myocardial mechanical restitution and potentiation could partly account for both alternans and monotonic decay of PESP. We conclude that myocardial mechanical restitution and potentiation may partly underlie the initial two alternating beats, the first beat being the most potentiated and the second beat being the most depressed, of alternans PESP decay in the canine heart.
authors.affiliation: Department of Physiology II, Okayama University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Mohri
authors.forename: J
authors.initials: J
authors.lastname: Araki
authors.forename: T
authors.initials: T
authors.lastname: Imaoka
authors.forename: G
authors.initials: G
authors.lastname: Iribe
authors.forename: M
authors.initials: M
authors.lastname: Maesako
authors.forename: J
authors.initials: J
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Matsubara
authors.forename: T
authors.initials: T
authors.lastname: Ohe
authors.forename: M
authors.initials: M
authors.lastname: Hirakawa
authors.forename: H
authors.initials: H
authors.lastname: Suga
mesh_terms: D000818:Animals; D003198:Computer Simulation; D004285:Dogs; D004562:Electrocardiography; D006329:Heart Conduction System / Q000502:physiology*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology