[The cause of infection as the main or additional cause of death in patients treated for small cell lung cancer].
In 116 out of 845 patients treated for small cell lung cancer (SCLC) in the Institute of Tuberculosis and Chest Disease in Warsaw in the years 1980-1994 infection was the main or coexistent cause of death. In 4.1% infection was proved of bacterial origin and in further 6.5% of probable bacterial origin (in the later group cultures were negative or not done but fungal infection, pneumocystosis pneumonia and tuberculosis were excluded on autopsy). In 1.54% infection was of fungal origin, 1.2% patients died of Pneumocystis carinii pneumonia and 0.35% of tuberculosis. The majority of patients who died with and/or from infection had treatment-related leukopenia and 99 of them were treated with corticosteroids. Fungal infection, pneumocytosis and tuberculosis were found more frequently than bacterial infection in patients treated with cumulative dose of prednisone above 2000 mg. 33.62% patients had no symptoms or signs of infection. No connection was found between the absence of symptoms and treatment with steroids or the grade of leukopenia. In all cases infection was recognised very late, in 58 only at autopsy.
Remiszewski
P
P
III Kliniki Gruźlicy i Chorób Płuc.
Słodkowska
J
J
Szczepek
B
B
Zwolska
Z
Z
Radomski
P
P
Byszewska
D
D
Rowińska-Zakrzewska
E
E
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000175:diagnosis / Q000453:epidemiology*; D018288:Carcinoma, Small Cell / Q000188:drug therapy / Q000453:epidemiology*; D002423:Cause of Death; D015897:Comorbidity; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced / Q000453:epidemiology; D008175:Lung Neoplasms / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000175:diagnosis / Q000453:epidemiology*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000453:epidemiology*; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects; D014376:Tuberculosis / Q000175:diagnosis / Q000453:epidemiology*
D011241:Prednisone