Searching for specificity in SH domains.
Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.
Ladbury
J E
JE
Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, UK. j.ladbury@biochem.ucl.ac.uk
Arold
S
S
D000818:Animals; D001665:Binding Sites; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D018909:src Homology Domains / Q000502:physiology*