Symptomatic and neuroprotective properties of the aliphatic propargylamines.
This short review describes the development of several families of aliphatic propargylamine drugs. The parent family--the aliphatic N-methylpropargylamines are potent, specific, irreversible MAO-B inhibitors, like R-deprenyl; but devoid of R-deprenyl's toxicity and amphetaminergic effects. In addition the parent drugs are potent antiapoptoic agents. Their desmethyl and further oxidized metabolites whilst devoid of MAO-B inhibitory properties of R-2HMP (our chosen drug candidate) are described along with the suggestion that this drug be developed for the treatment of several human neurodegenerative conditions.
Boulton
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Neuropsychiatry Research Unit, University of Saskatchewan, Saskatoon, Canada. boulton@sask.usask.ca
D000480:Alkynes / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*
D000480:Alkynes; D008996:Monoamine Oxidase Inhibitors; C402679:N-2-heptyl-N-methylpropargylamine