title: Size, node status and grade of breast tumours: association with mammographic parenchymal patterns.
abstract: A case-control study was designed to assess the association of mammographic parenchymal patterns with the risk of in-situ and invasive breast cancer. In addition, the relationship between tumour characteristics and mammographic patterns were also investigated. A total of 875 patients with breast cancer were selected and matched with 2601 controls. Mammographic parenchymal patterns of breast tissue were assessed according to Wolfe's classification, and statistical analysis was by conditional logistic regression. Relative to the N1 pattern, the odds ratios of having an invasive breast cancer associated with the P2 and DY patterns were 1.8 and 1. 4, respectively. In addition, the odd ratios of having an invasive grade 3 breast cancer associated with the P2 and DY patterns were 2. 8 and 3.9, respectively. Relative to the combined N1/P1 pattern, the odd ratios of having a breast cancer smaller than 14 mm, 15-29 mm, or larger than 30 mm associated with the combined high-risk P2/DY pattern (P2 + DY) were 1.2, 1.6, and 2.0, respectively. Finally, women with the P2/DY pattern were twice as likely to have a breast cancer which had already spread to the axillary nodes, compared to women with women with the N1/P1 pattern (odds ratios of 2.1 and 1.4, respectively). Our results confirm previous findings suggesting that mammographic parenchymal patterns may serve as indicators of risk for breast cancer. Our results also suggest that mammographic parenchymal patterns are associated with the stage at which breast cancer is detected.
authors.affiliation: Department of Community Medicine, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK.
authors.forename: E
authors.initials: E
authors.lastname: Sala
authors.forename: L
authors.initials: L
authors.lastname: Solomon
authors.forename: R
authors.initials: R
authors.lastname: Warren
authors.forename: J
authors.initials: J
authors.lastname: McCann
authors.forename: S
authors.initials: S
authors.lastname: Duffy
authors.forename: R
authors.initials: R
authors.lastname: Luben
authors.forename: N
authors.initials: N
authors.lastname: Day
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000473:pathology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008327:Mammography