title: Double-blind comparison of sevofluran vs propofol and succinylcholine for tracheal intubation in children.
abstract: We have studied intubating conditions in 64 healthy children, aged 3-10 yr, undergoing adenotonsillectomy, in a double-blind, randomized study. Intubation was performed 150 s after induction using either 8% sevoflurane in nitrous oxide and oxygen or propofol 3-4 mg kg-1 with succinylcholine 2 mg kg-1. An anaesthetist blinded to the technique performed intubation and scored intubating conditions using Krieg and Copenhagen Consensus Conference (CCC) scores. The trachea was intubated successfully at the first attempt in all patients under clinically acceptable conditions, although scores were significantly better with propofol and succinylcholine. The sevoflurane technique cost 3.62 +/- 0.55 Pounds to completion of tracheal intubation, significantly more (P < 0.001) than the cost of propofol-succinylcholine and isoflurane (2.04 +/- 0.54 Pounds) when based on actual amount of drug used. This cost increased to 4.38 +/- 0.05 Pounds when based on whole ampoules, which is significantly more than the cost of sevoflurane (P < 0.001).
authors.affiliation: North Staffordshire Hospital, Stoke-on-Trent, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Thwaites
authors.forename: S
authors.initials: S
authors.lastname: Edmends
authors.forename: A A
authors.initials: AA
authors.lastname: Tomlinson
authors.forename: J B
authors.initials: JB
authors.lastname: Kendall
authors.forename: I
authors.initials: I
authors.lastname: Smith
mesh_terms: D000233:Adenoidectomy; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D008297:Male; D008738:Methyl Ethers; D009467:Neuromuscular Depolarizing Agents; D015742:Propofol; D000077149:Sevoflurane; D013390:Succinylcholine; D014068:Tonsillectomy
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D009467:Neuromuscular Depolarizing Agents; D000077149:Sevoflurane; D013390:Succinylcholine; D015742:Propofol