clk-1, mitochondria, and physiological rates.
Mutations in the C. elegans maternal-effect gene clk-1 are highly pleiotropic, affecting the duration of diverse developmental and behavioral processes. They result in an average slowing of embryonic and post-embryonic development, adult rhythmic behaviors, reproduction, and aging.(1) CLK-1 is a highly conserved mitochondrial protein,(2,3) but even severe clk-1 mutations affect mitochondrial respiration only slightly.(3) Here, we review the evidence supporting the regulatory role of clk-1 in physiological timing. We also discuss possible models for the action of CLK-1, in particular, one proposing that CLK-1 is involved in the coordination of mitochondrial and nuclear function. BioEssays 22:48-56, 2000.
Branicky
R
R
Department of Biology, McGill University, Montréal, Québec, Canada.
Bénard
C
C
Hekimi
S
S
D000595:Amino Acid Sequence; D000818:Animals; D001683:Biological Clocks; D002107:Caenorhabditis / Q000235:genetics / Q000502:physiology; D029742:Caenorhabditis elegans Proteins; D017124:Conserved Sequence; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D008969:Molecular Sequence Data; D012281:Rickettsia / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
C104339:CLK-1 protein, C elegans; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins