title: Linear combination steady-state free precession MRI.
abstract: A new, fast, spectrally selective steady-state free precession (SSFP) imaging method is presented. Combining k-space data from SSFP sequences with certain phase schedules of radiofrequency excitation pulses permits manipulation of the spectral selectivity of the image. For example, lipid and water can be resolved. The contrast of each image depends on both T1 and T2, and the relative contribution of the two relaxation mechanisms to image contrast can be controlled by adjusting the flip angle. Several potential applications of the technique, referred to as linear combination steady-state free precession (LCSSFP), are demonstrated: fast musculoskeletal, abdominal, angiographic, and brain imaging.
authors.affiliation: Department of Electrical Engineering, Stanford University, California, USA. vasanawala@stanford.edu
authors.forename: S S
authors.initials: SS
authors.lastname: Vasanawala
authors.forename: J M
authors.initials: JM
authors.lastname: Pauly
authors.forename: D G
authors.initials: DG
authors.lastname: Nishimura
mesh_terms: D001808:Blood Vessels / Q000033:anatomy & histology / Q000378:metabolism; D001834:Body Water / Q000737:chemistry*; D001921:Brain / Q000033:anatomy & histology; D003238:Connective Tissue / Q000033:anatomy & histology* / Q000378:metabolism; D003287:Contrast Media; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D016014:Linear Models; D008055:Lipids / Q000737:chemistry*; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009141:Musculoskeletal System / Q000033:anatomy & histology* / Q000378:metabolism; D019047:Phantoms, Imaging; D011150:Popliteal Artery / Q000033:anatomy & histology; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D008055:Lipids