Kinetics of plasma and tissue distribution of 9-cis-retinoic acid in rat.
The biotransformation and tissue distribution of 9-cis-retinoic acid was investigated in hairless rats. Indeed, only limited information is available about the pharmacokinetics of 9-cis-retinoic acid. Assuming that the target site for retinoids is the skin, tissue distribution study is therefore particularly justified. Following single oral administration of 30 mg/kg of 9-cis-retinoic acid, the parent drug and five metabolites were detected in plasma. Additionally, concentrations of 9-cis-retinoic acid and metabolites were determined in the skin and seven other tissues. The distribution of 9-cis-retinoic acid was rapid in all of the organs studied (T(max) </=2 h). In skin, unchanged 9-cis-retinoic acid was still measurable up to 168 h after administration and was undetectable in other organs and plasma after 48 h.
Disdier
B
B
Laboratoire de Toxicologie et Pharmacie Clinique, Faculté de Pharmacie, Marseille, France.
Marchetti
M N
MN
Bun
H
H
Placidi
M
M
Durand
A
A
D000077556:Alitretinoin; D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000493:pharmacokinetics*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D008297:Male; D051381:Rats; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution; D014212:Tretinoin / Q000097:blood / Q000493:pharmacokinetics*
D000970:Antineoplastic Agents; D000077556:Alitretinoin; D014212:Tretinoin