Lethal seizures predicted after aminophylline therapy in cocaine abusers.
Mice with a history of chronic (10 days), but not acute, treatment with a non-convulsant dose of cocaine showed increased sensitivity (P<0.001) to the toxic effects of aminophylline (seizures, lethality) relative to controls even days after the cessation of cocaine treatment. The present finding suggests that individuals with a history of cocaine use may be at increased risk for convulsive and lethal complications associated with the therapeutic use of aminophylline.
Gasior
M
M
Drug Development Group, Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. mgasior@intra.nida.nih.gov
Ungard
J T
JT
Witkin
J M
JM
D000628:Aminophylline / Q000633:toxicity*; D000818:Animals; D019970:Cocaine-Related Disorders / Q000150:complications*; D008297:Male; D051379:Mice; D012640:Seizures / Q000139:chemically induced*
D000628:Aminophylline