Relating axonal injury to functional recovery in MS.
A patient was followed after the new onset of hemiparesis from relapse of MS with serial MR spectroscopy and functional MRI. The association of clinical improvement with recovery of N-acetylaspartate, a marker of neuronal integrity, and progressive reduction of abnormally large functional MRI cortical activation with movement demonstrates that dynamic reorganization of the motor cortex accompanies remission of MS.
Reddy
H
H
Department of Neurology and Neurosurgery, Montreal-Neurological Institute, McGill University, Canada.
Narayanan
S
S
Matthews
P M
PM
Hoge
R D
RD
Pike
G B
GB
Duquette
P
P
Antel
J
J
Arnold
D L
DL
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001369:Axons / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D009473:Neuronal Plasticity; D020127:Recovery of Function; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology
D001224:Aspartic Acid; C000179:N-acetylaspartate