Prediction of respiratory distress syndrome by the level of pulmonary surfactant protein A in cord blood sera.
The purpose of this study was to determine the utility of measuring the level of pulmonary surfactant protein A (SP-A) in cord blood sera to predict for respiratory distress syndrome (RDS). SP-A levels in cord blood sera from 48 infants born at gestational ages < 32 weeks were measured by a sandwich ELISA system. Mean value of SP-A in cord blood was 5.8 ng/ml in cases with RDS and 15.1 ng/ml in those without RDS (p = 0.002). The best cut-off point of cord blood SP-A to predict RDS was determined as 10 ng/ml. The sensitivity and the specificity of the cut-off point for predicting RDS were 81 and 76%, respectively. Multivariate regression analysis showed that high SP-A level in cord blood, premature rupture of the membranes longer than 24 h and heavy birth weight were all significantly related to the non-RDS outcome.
Cho
K
K
Departments of Obstetrics and Gynecology, and Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan. chotarou@med.hokudai.ac.jp
Matsuda
T
T
Okajima
S
S
Matsumoto
Y
Y
Sagawa
T
T
Fujimoto
S
S
Kobayashi
K
K
D001724:Birth Weight; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005322:Premature Rupture of Fetal Membranes / Q000097:blood; D005865:Gestational Age; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011510:Proteolipids / Q000097:blood*; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000097:blood*; D012044:Regression Analysis; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants