Rapidly progressive cholestasis: An unusual reaction to amoxicillin/clavulanic acid therapy in a child.
Hepatotoxity associated with amoxicillin/clavulanic acid is usually a self-limited disease with complete recovery. We report a rapidly progressing liver disease with ductopenia and portal fibrosis in a 3-year-old boy treated with Augmentin.
Chawla
A
A
Departments of Pediatrics and Pathology, North Shore University Hospital, New York University School of Medicine, Manhasset, New York 11030, USA.
Kahn
E
E
Yunis
E J
EJ
Daum
F
F
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001649:Bile Duct Diseases / Q000139:chemically induced; D001653:Bile Ducts, Intrahepatic / Q000187:drug effects; D002675:Child, Preschool; D002779:Cholestasis / Q000139:chemically induced*; D003875:Drug Eruptions / Q000209:etiology; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D008099:Liver / Q000187:drug effects; D008103:Liver Cirrhosis / Q000139:chemically induced; D008297:Male
D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination