title: Accurate localization of an insulinoma by preoperative selective intra-arterial calcium injection and intraoperative glucose monitoring.
abstract: The role of pre- and intraoperative procedures for the localization of insulinomas has been extensively debated. We report a case of successful treatment using preoperative selective intra-arterial calcium injection and intraoperative glucose monitoring. A 12-year-old boy with hypoglycemic attacks had a large insulinoma in the head of the pancreas on computed tomography. Preoperative selective angiography combined with arterial stimulation-venous sampling (ASVS) by intra-arterial injection of calcium revealed no other insulinomas in the body and tail of the pancreas. Elevation of serum glucose on intraoperative monitoring confirmed complete enucleation of the insulinoma. Preoperative ASVS can accurately localize an insulinoma, and may help to increase the success rate of surgery and avoid blind pancreatectomy.
authors.affiliation: Division of Surgery, Saitama Children's Medical Center, 2100 Magome, Iwatsuki, Saitama 339-8551, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwanaka
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: N
authors.initials: N
authors.lastname: Koda
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: T
authors.initials: T
authors.lastname: Aihara
authors.forename: S
authors.initials: S
authors.lastname: Imaizumi
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002125:Calcium Gluconate / Q000008:administration & dosage; D002648:Child; D006801:Humans; D007269:Injections, Intra-Arterial; D007328:Insulin / Q000097:blood; D007340:Insulinoma / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000601:surgery*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D002125:Calcium Gluconate