Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13-acetate (TPA) or peroxynitrite/TPA.
Konoshima
T
T
Kyoto Pharmaceutical University, Japan. konosima@mb.kyoto-phu.ac.jp
Takasaki
M
M
Ichiishi
E
E
Murakami
T
T
Tokuda
H
H
Nishino
H
H
Duc
N M
NM
Kasai
R
R
Yamasaki
K
K
D000477:Alkylating Agents; D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D015197:Carcinogenicity Tests; D002273:Carcinogens; D004052:Diethylnitrosamine; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000139:chemically induced / Q000517:prevention & control; D036145:Ginsenosides; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D018632:Mice, Inbred SENCAR; D009566:Nitrates; D009574:Nitro Compounds; D005894:Panax / Q000737:chemistry*; D010212:Papilloma / Q000139:chemically induced / Q000517:prevention & control; D010634:Phenobarbital; D010946:Plants, Medicinal; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013755:Tetradecanoylphorbol Acetate; D014744:Vietnam
D000477:Alkylating Agents; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D036145:Ginsenosides; D009566:Nitrates; D009574:Nitro Compounds; D012503:Saponins; C101316:methyl-2-hydroxyimino-5-nitro-6-methoxy-3-hexeneamide; C039642:peroxynitric acid; D004052:Diethylnitrosamine; C098043:majonoside R2; D013755:Tetradecanoylphorbol Acetate; D010634:Phenobarbital