A new convenient transformation of erythromycin A into clarithromycin.
Erythromycin A was transformed into clarithromycin by the sequence of reactions: selective thexyldimethylsilylation of the 9-oxime, trimethylsilylation of the 2',4''-hydroxy groups, methylation of the resulting 2',4''-[O-bis(trimethylsilyl)]-9-[O-(dimethylthexylsilyl)oxime] and acidic regeneration of the protected functionalities.
Allevi
P
P
Dipartimento di Chimica e Biochimica Medica, University of Milan, Italy. pietro.allevi@unimi.it
Longo
A
A
Anastasia
M
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D017291:Clarithromycin / Q000138:chemical synthesis* / Q000737:chemistry*; D004917:Erythromycin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods
D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017291:Clarithromycin