RING for destruction?
Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. Recent results implicate the RING finger domain in specific ubiquitination events; it is possible that all RING proteins act as E3 ubiquitin protein ligases, with implications for a variety of biological areas.
Freemont
P S
PS
Molecular Structure and Function Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK. freemont@icrf.icnet.uk.
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism*
D011506:Proteins; D014452:Ubiquitins