title: Post-trauma coagulation and fibrinolysis in children suffering from severe cerebro-cranial trauma.
abstract: The present study was designed to evaluate the post-trauma haemostatic changes in 27 children with severe cranio-cerebral trauma defined by a modified Glasgow Coma Score (GCS) < 10. Blood samples for coagulation studies (fibrinogen, von Willebrand factor (vWf), factor VIII:C, antithrombin, protein C, plasminogen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI), D-dimer) were obtained within two hours of admission, 24 h later, and on days 3-5, 7-9, 21 and 35. Data of this study indicate that alterations of coagulation in paediatric patients are similar to those in adults: On hospitalisation, activated haemostasis was found with decreased fibrinogen, antithrombin and protein C along with enhanced t-PA and PAI. Twenty-four hours later, hypercoagulability with significantly increased vWF and fibrinogen started, with a peak level within the second week. Within 24 h of admission, 17 children developed disseminated intravascular coagulation (DIC) with a clear-cut decrease of antithrombin and fibrinogen together with platelet consumption and enhanced D-dimer. The outcome of children with DIC was significantly poorer than in those without DIC. Complete recovery was seen in five patients; sequelae no handicap and moderate disability were each found in six patients. Severe disability was diagnosed in two children, and fulminant DIC with lethal outcome occurred in eight patients. The GCS (P < 0.01) and the occurrence of DIC (P < 0.005) showed the strongest association with the patients' clinical outcome.
  
  
  CONCLUSIONS
  Our data underline the significance of post-trauma disturbances of the haemostatic system for the clinical course and outcome in children with severe cranio-cerebral injuries.
authors.affiliation: Department of Paediatrics, University Hospital Frankfurt am Main, Germany. sbecker@uni-frankfurt.de
authors.forename: S
authors.initials: S
authors.lastname: Becker
authors.forename: W
authors.initials: W
authors.lastname: Schneider
authors.forename: W
authors.initials: W
authors.lastname: Kreuz
authors.forename: G
authors.initials: G
authors.lastname: Jacobi
authors.forename: I
authors.initials: I
authors.lastname: Scharrer
authors.forename: U
authors.initials: U
authors.lastname: Nowak-Göttl
mesh_terms: D000293:Adolescent; D001777:Blood Coagulation; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006259:Craniocerebral Trauma / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005342:Fibrinolysis; D015600:Glasgow Coma Scale; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D001779:Blood Coagulation Factors