Fibrin glue reduces intra-abdominal adhesions to synthetic mesh in a rat ventral hernia model.
Postoperative intra-abdominal adhesions are associated with significant morbidity and mortality. In this study, the effect of topical fibrin glue (FG) on adhesion formation in a rat model was investigated. Forty Sprague-Dawley male rats underwent midline laparotomy. Bilateral peritoneal-muscular abdominal wall defects were created and then replaced with premeasured soft tissue Goretex patches. Rats were randomized to FG sprayed over the patches or to a control group. Two observers blinded to the randomization assessed the severity of adhesions to the patch by scoring the density of adhesions (grades 0-3) and the percentage of the patch area covered by adhesions (0-100%). The mean percentage of the patch covered by adhesions was 32.8 +/- 6.1 per cent for the FG group versus 57.9 +/- 6.7 per cent for the control group (P < 0.01). The mean density of adhesions for the FG group was 0.95 (+/-0.17) versus 2.0 (+/-0.21) for the control group (P = 0.001). Topical FG reduces the severity and density of intra-abdominal adhesions in a rat model.
Toosie
K
K
Department of Surgery, Harbor-UCLA Medical Center, Torrance, California 90509, USA.
Gallego
K
K
Stabile
B E
BE
Schaber
B
B
French
S
S
de Virgilio
C
C
D000009:Abdominal Muscles / Q000601:surgery*; D000818:Animals; D004195:Disease Models, Animal; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006555:Hernia, Ventral / Q000601:surgery; D007813:Laparotomy; D008297:Male; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D014014:Tissue Adhesives / Q000627:therapeutic use*
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D011138:Polytetrafluoroethylene