Vaccines and the induction of functional antibodies: time to look beyond the molecules of natural infection?
Infection with some pathogens induces weak functional antibody responses that are non-protective, and there has been some skepticism about a role for antibodies in vaccine design. However, newer data show that antibodies can protect against infection with these pathogens, and new methods to elicit production of functional antibodies should be sought.
Burton
D R
DR
Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA. burton@scripps.edu
Parren
P W
PW
D000917:Antibody Formation; D015699:HIV Envelope Protein gp120 / Q000276:immunology; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D009500:Neutralization Tests; D014612:Vaccines / Q000008:administration & dosage*
D015699:HIV Envelope Protein gp120; D014612:Vaccines