Confirmation of paternal disomy in a twin molar pregnancy. A case report.
BACKGROUND
Paternal dispermy can be the pathogenesis of complete molar pregnancy.


METHODS
A 23-year-old, white woman, gravida 4, para 1, was pregnant with a twin gestation by ovulation induction with metrodin. Ultrasound evaluation confirmed an intrauterine pregnancy in conjunction with what appeared to be a hydatidiform mole. The karyotype in the molar pregnancy, obtained from chorionic villus sampling, showed a pair of paternally derived inverted chromosomes 9, confirming the diagnosis of a complete mole. Uncontrollable hemorrhage with a rapid rise in the beta-human chorionic gonadotropin titer necessitated evacuation of the uterus. The patient was followed with beta-human chorionic gonadotropin titers for a year, with no evidence of recurrence.


CONCLUSIONS
This case illustrates paternal disomy in a complete molar pregnancy documented by a paternal chromosome 9 inversion.
Kirshon
B
B
Houston Perinatal Associates and Laboratories for Genetic Services, Inc., Texas 77054, USA.
Reiter
A
A
Adam
K
K
Cheung
S W
SW
D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9; D004200:Diseases in Twins; D005220:Fathers; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000235:genetics*; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014427:Twins
D018997:Chorionic Gonadotropin, beta Subunit, Human; D008596:Menotropins