[Integrative mechanisms of the formation of the small intestine motor effects].
Contractile responses of the small intestine to serotonine and histamine are mediated by cholinergic neurones, while the inhibitory responses of the substances--by nonadrenergic inhibitory neurones of the enterometasympathetic nervous system. An inhibitory response of the small intestine to met-enkephalin results from its depressing action on the effector cholinergic neurones. Catecholamines activate enteric cholinergic neurones via presynaptic beta-adrenoceptors and inhibit them via pre- and postsynaptic alpha-adrenoceptors. The cholinergic neurones of the enterometasympathetic nervous system seem to be under a double adrenergic control, and a mechanisms seems to exist in the small intestine for adrenergic activation of its contractile apparatus.
Ovsiannikov
V I
VI
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D004744:Enkephalin, Methionine / Q000502:physiology; D006632:Histamine / Q000502:physiology; D007421:Intestine, Small / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000294:innervation / Q000378:metabolism / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012701:Serotonin / Q000502:physiology
D011943:Receptors, Adrenergic, beta; D012701:Serotonin; D004744:Enkephalin, Methionine; D006632:Histamine; D000109:Acetylcholine