title: Efficient Hydrolysis of RNA by a PNA - Diethylenetriamine Adduct.
abstract: The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin-bound peptide nucleic acid (PNA) decamer gave access to a PNA - DETA adduct (shown here), which hydrolyzed the target 25-mer RNA rapidly and sequence specifically.
authors.affiliation: Leiden Institute of Chemistry Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden (The Netherlands).
authors.initials: JC
authors.lastname: Verheijen
authors.initials: BA
authors.lastname: Deiman
authors.initials: E
authors.lastname: Yeheskiely
authors.lastname: van Der Marel GA
authors.lastname: van Boom JH