Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate.
N-(N'-Phenethylthiocarbamoyl) derivatives of sphingosine and sphinganine were prepared. They had antitumour activity: GC50 values of 0.64+/-0.02 microM (N = 18) and 1.6+/-0.01 microM (N = 18). respectively, with human leukaemia 60 cells in vitro. This antitumour effect may contribute to the suppression of carcinogenesis associated with dietary phenethyl isothiocyanate and sphingolipid bases.
Xu
K
K
Department of Biological Sciences, University of Essex, Colchester, UK.
Thornalley
P J
PJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D018922:HL-60 Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D017879:Isothiocyanates / Q000737:chemistry* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D017879:Isothiocyanates; C058305:phenethyl isothiocyanate; D013110:Sphingosine; C005682:safingol