[Atropine effect on physostigmine- and stress-induced secretion of catecholamines by adrenal gland: microdialysis study in awake rats].
Physostigmine and an 1-hour immobilisation stress similarly affected functions of the sympatho-adrenal and cardiovascular systems activating the catecholamine secretion and increasing the blood pressure. Yohimbine potentiated the secretory effect but did not change the pressor effect. Intermediate administration of atropine completely eliminated both effects of physostigmine but, being administered prior to the immobilisation, it potentiated the secretory response without affecting the pressor response. The findings reveal a difference in central cholinergic mechanisms of neurohumoral and haemodynamic responses to physostigmine and stress.
Kuz'min
A I
AI
Cardiological Research-Industrial Complex, Moscow, Russia.
Kalenikova
E I
EI
Zaretskaia
M V
MV
Zaretskiĭ
D V
DV
Zakharova
N V
NV
Medvedev
O S
OS
Chazov
E I
EI
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D017551:Microdialysis; D018721:Muscarinic Agonists / Q000494:pharmacology*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*; D014851:Wakefulness
D002395:Catecholamines; D018721:Muscarinic Agonists; D001285:Atropine; D010830:Physostigmine