HIV-1 protease inhibition and anti-HIV effect of natural and synthetic water-soluble lignin-like substances.
Water-soluble lignin extracted from natural sources and dehydrogenated polymers of p-coumaric acid and ferulic acid inhibited HIV-1 protease activity. The dehydrogenated polymers, which are thought to be model compounds for lignin, were synthesized and fractionated into four ranges of molecular mass by ultra-filtration: i.e., over 30 kDa, 30-10 kDa, 10-1 kDa and 1 kDa-500 Da. All of these fractions had HIV-1 protease inhibitory activity. The anti-HIV-1 effect of the smallest mass fractions of the dehydrogenated polymers (1 kDa-500 Da) was also tested, and it was found that these fractions inhibited the replication of HIV-1 in MT-4 cells.
Ichimura
T
T
National Institute of Bioscience and Human-Technology, Agency of Industrial Science and Technology, Ibaraki, Japan.
Otake
T
T
Mori
H
H
Maruyama
S
S
D002460:Cell Line; D004043:Dietary Fiber; D016333:HIV Protease / Q000378:metabolism*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008031:Lignin / Q000494:pharmacology*; D008970:Molecular Weight; D010455:Peptides / Q000378:metabolism; D012995:Solubility; D014462:Ultrafiltration; D014867:Water
D004043:Dietary Fiber; D017320:HIV Protease Inhibitors; D010455:Peptides; D014867:Water; D008031:Lignin; D016333:HIV Protease