Clinico-laboratory characteristics of patients with dermatomyositis accompanied by rapidly progressive interstitial lung disease.
The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n = 7) and those with chronic interstitial lung disease (C-ILD, n = 9), and also between deceased (seven RP-ILD and three C-ILD) and living patients (six C-ILD). The extent of muscle weakness of the extremities and frequency of autoantibody positivity were significantly lower in DM patients with RP-ILD than in DM patients with C-ILD. Furthermore, significantly lower serum creatine kinase/lactate dehydrogenase levels (0.26+/-0.27) were found in the 10 patients who died than in the six living patients (1.21+/-1.09). A higher CD4+/CD8+ T-lymphocyte ratio in the peripheral blood (3.51+/-2.65) was detected in the four DM patients with RP-ILD who died than in the six living DM patients with C-ILD (1.22+/-0.49).
Ito
M
M
Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima City, Japan.
Kaise
S
S
Suzuki
S
S
Kazuta
Y
Y
Sato
Y
Y
Miyata
M
M
Nishimaki
T
T
Nakamura
N
N
Kasukawa
R
R
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016516:CD4-CD8 Ratio; D003402:Creatine Kinase / Q000378:metabolism; D003882:Dermatomyositis / Q000097:blood / Q000150:complications* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000473:pathology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology; D013902:Radiography, Thoracic; D016176:T-Lymphocyte Subsets / Q000473:pathology; D014057:Tomography, X-Ray Computed
D000974:Antibodies, Antinuclear; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase