title: Dorsoventral differential distribution of collagen type XIV around the spinal cord is regulated by the ectoderm.
abstract: Regional specification in the nervous system is a critical issue in nervous system morphogenesis. Along the dorsoventral axis of the spinal cord, ventral inductive signals of the notochord and floor plate, and dorsal ones of the epidermal ectoderm are essential. Collagen type XIV is uniquely distributed around the spinal cord with a gradient of dorsal high and ventral low at the early developmental stages of the chick embryo. In the present study it was found that collagen type XIV expression around the spinal cord was entirely regulated by the ectoderm and that even the ventralizing tissues, the notochord and floor plate, themselves could be influenced to express this molecule by the ectoderm.
authors.affiliation: Division of Developmental Neurobiology, Kumamoto University Graduate School of Medical Sciences, Honjo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: S
authors.initials: S
authors.lastname: Hirano
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D002642:Chick Embryo; D003094:Collagen / Q000378:metabolism*; D004475:Ectoderm / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000378:metabolism*; D007150:Immunohistochemistry; D009024:Morphogenesis; D009672:Notochord / Q000378:metabolism; D013116:Spinal Cord / Q000196:embryology* / Q000378:metabolism; D016378:Tissue Transplantation
chemical_list: C054447:COL14A1 protein, human; D006023:Glycoproteins; D003094:Collagen