Pathogenetic factors and clinical elements in ascites and hepatorenal syndrome during liver cirrhosis.
Ascites is the most frequent major complication of liver cirrhosis. Even if a significant decrease in renal clearances may be observed in the first stages of chronic active hepatitis, true renal impairment, often with the typical signs of hepatorenal syndrome, only occurs in patients with ascites, especially when tense and refractory. Experimental and clinical data suggest the presence of primary sodium and water retention, perhaps as a consequence of an increase in intrahepatic hydrostatic pressure. The abnormal sodium retention leads to plasma volume expansion, followed by decreased peripheral vascular resistances and increased cardiac output. This second stage concords with the peripheral arterial vasodilation theory, characterized by an increase in total blood volume, but with a decrease in effective arterial blood volume. This discrepancy leads to the activation of sympathetic nervous and renin-angiotensin-aldosterone systems. This activation, while protective against splanchnic and systemic vasodilation, provoked by the increased availability of nitric oxide and other vasodilating substances, induces renal vasoconstriction. This phenomenon can be considered as the basis of the progressive renal failure that leads to hepatorenal syndrome, favored by progressive exhaustion of the renal autacoid vasodilating substances. The first therapeutic approach to ascites is sequential and based on diuretic administration. Subsequently, paracentesis with albumin infusion is carried out, as well as transjugular intrahepatic portosystemic shunting, surgical portosystemic shunting, and liver transplantation: these procedures are essential for the treatment of hepatorenal syndrome.
Gentilini
P
P
Dipartimento di Medicina Interna, Università degli Studi di Firenze.
Laffi
G
G
La Villa
G
G
Raggi
V C
VC
D001201:Ascites / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D015984:Causality; D003937:Diagnosis, Differential; D006439:Hemodynamics; D006530:Hepatorenal Syndrome / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D045283:Natriuretic Agents / Q000502:physiology; D051437:Renal Insufficiency / Q000175:diagnosis; D012964:Sodium / Q000378:metabolism; D014667:Vasopressins / Q000502:physiology; D014867:Water / Q000378:metabolism
D045283:Natriuretic Agents; D014867:Water; D014667:Vasopressins; D012964:Sodium