Ceramide in the eukaryotic stress response.
Several extracellular agents and stress stimuli, such as tumour necrosis factor alpha, chemotherapeutic agents and heat, cause ceramide accumulation. They do this by regulating enzymes involved in its metabolism. Ceramide modulates a number of biochemical and cellular responses to stress, including apoptosis, cell-cycle arrest and cell senescence.
Hannun
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Dept of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston 29495, USA. hannun@musc.edu
Luberto
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D000818:Animals; D002518:Ceramides / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects; D013109:Sphingomyelins / Q000378:metabolism / Q000502:physiology; D013312:Stress, Physiological / Q000378:metabolism*
D002518:Ceramides; D013109:Sphingomyelins