Lung cancer in a child with a substantial family history of cancer.
The occurrence of primary lung cancer is rare in childhood. The case of an 11-year-old boy with primary lung cancer is presented in this report. He had a substantial family history of cancer. His chief complaint was coughing with right chest pain. A chest radiograph showed a coin lesion in the right lower lung. A right lower lobectomy revealed a squamous cell carcinoma (stage IIIA at Japanese TNM classification). Systemic chemotherapy using cisplatin, vindesine, THP-adriamycin and cyclophosphamide was performed. Six months after surgery, a recurrent tumor occurred. An analysis of the familial cancer related genes (p53 gene and mismatch repair gene) showed no abnormality.
Tajiri
T
T
Department of Pediatric Surgery and Pathology, Kyushu University, Fukuoka, Japan.
Suita
S
S
Shono
K
K
Kubota
M
M
Taguchi
T
T
Yamanouchi
K
K
Noguchi
S
S
Tsuneyoshi
M
M
D017668:Age of Onset; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D002648:Child; D017809:Fatal Outcome; D016158:Genes, p53; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D008297:Male; D018895:Microsatellite Repeats; D009369:Neoplasms / Q000235:genetics