title: Memory and learning are not impaired in presymptomatic individuals with an increased risk of Huntington's disease.
abstract: Retrieval from long-term memory in patients with brain injuries was investigated with a memory scanning paradigm (Conway & Engle, 1994), that allows dissociation of scanning processes within short-term memory and memory retrieval processes from long-term memory. The study focused on the influence of brain injury on memory retrieval processes that are assumed to be automatic. Thirteen patients with memory impairment and 13 healthy matched control subjects were tested. In general, patients showed increased reaction times, but they showed set size independent retrieval from long-term memory indicating preserved automatic retrieval processes. In a subgroup of patients with more severe memory deficits, however, automatic retrieval processes appeared not to be intact. Learning profiles of the patients were characterized by smaller item chunks, indicating differences in the process of information acquisition.
authors.affiliation: Department of Neurology, Leiden University Medical Centre, The Netherlands.
authors.forename: G M
authors.initials: GM
authors.lastname: de Boo
authors.forename: A A
authors.initials: AA
authors.lastname: Tibben
authors.forename: J A
authors.initials: JA
authors.lastname: Hermans
authors.forename: A
authors.initials: A
authors.lastname: Jennekens-Schinkel
authors.forename: A
authors.initials: A
authors.lastname: Maat-Kievit
authors.forename: R A
authors.initials: RA
authors.lastname: Roos
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D006816:Huntington Disease / Q000235:genetics* / Q000523:psychology*; D007858:Learning; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D018570:Risk Assessment