title: [Individual predisposition to lung neoplasm--the role of genes involved in metabolism of carcinogens].
abstract: Molecular epidemiology of lung cancer analyses relationship between environment and individual susceptibility. Studying biomarkers of risk at the molecular level allows better understanding of chemical carcinogenesis processes and makes possible early detection of the disease as well as helps its prevention. Risk biomarkers include genetic polymorphism of CYP, GST and NAT genes that participate in metabolic biotransformation of various endo- and exogenous compounds including carcinogens. Exposure to potentially carcinogenic environmental factors plays an important role in etiology of lung cancer, which remains a leading cause of cancer death worldwide. This review presents current knowledge about molecular basis and impact of individual variations in carcinogen metabolism on lung cancer risk.
authors.affiliation: Zakład Biologii Nowotworów, Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach.
authors.forename: D
authors.initials: D
authors.lastname: Butkiewicz
authors.forename: M
authors.initials: M
authors.lastname: Chorazy
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002273:Carcinogens / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D018736:DNA Adducts / Q000032:analysis; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000517:prevention & control; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D014408:Biomarkers, Tumor; D002273:Carcinogens; D018736:DNA Adducts; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase