Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40.
CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor kappaB (NF-kappaB)-inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-kappaB activation via CD40.
Garceau
N
N
Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Kosaka
Y
Y
Masters
S
S
Hambor
J
J
Shinkura
R
R
Honjo
T
T
Noelle
R J
RJ
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D019013:CD40 Antigens / Q000378:metabolism*; D023201:CD40 Ligand; D019556:COS Cells; D019070:Cell Lineage; D002478:Cells, Cultured; D004268:DNA-Binding Proteins / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D020672:I-kappa B Proteins; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000276:immunology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000276:immunology*; D015398:Signal Transduction; D000097782:NF-kappaB-Inducing Kinase
D019013:CD40 Antigens; D023201:CD40 Ligand; D004268:DNA-Binding Proteins; D020672:I-kappa B Proteins; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases; D000097782:NF-kappaB-Inducing Kinase; C000606205:Nfkbia protein, mouse