Maternal serum interleukin 1, 2, 6, 8 and interleukin-2 receptor levels in preterm labor and delivery.
OBJECTIVE
To determine the concentrations of maternal serum interleukins (ILs) 1, 2, 6, 8 and IL-2 receptors (IL-2R) in patients in their second and third trimesters of pregnancy and in preterm labor and delivery without evidence of chorioamnionitis.


METHODS
The study was conducted in La Paz Maternal Hospital, Madrid. Maternal serum IL concentrations were measured in 103 gravidas during preterm labor and delivery. The Mann-Whitney U test was used for analysis.


RESULTS
Women in preterm labor and delivery had significantly higher median IL-2R concentration. Women who responded to tocolysis had significantly lower serum concentrations of IL-6. IL-2R and IL-6 serum concentrations predict delivery in 48 h and before 34 weeks gestation.


CONCLUSIONS
Compared with non-laboring gravidas, those in idiopathic preterm labor or delivery had significantly higher concentrations of maternal serum IL-2R. Both IL-6 and IL-2R may predict failure of tocolysis. IL-2 does not seem to play an important role in pregnancy.
Alvarez-de-la-Rosa
M
M
Department of Obstetrics and Gynecology, La Paz Hospital, Universidad Autónoma de Madrid, Spain. obgyn.fellows@yale.edu
Rebollo
F J
FJ
Codoceo
R
R
Gonzalez Gonzalez
A
A
D015415:Biomarkers; D036861:Delivery, Obstetric; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D007752:Obstetric Labor, Premature / Q000097:blood* / Q000188:drug therapy; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood; D011263:Pregnancy Trimester, Third / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012680:Sensitivity and Specificity; D015145:Tocolysis
D015415:Biomarkers; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D007378:Interleukins; D015375:Receptors, Interleukin-2