title: Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats.
abstract: The injection of a dopamine D(2) receptor hammerhead ribozyme (20 microg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D(2) receptor agonist, quinpirole (0.4 mg kg(-1) s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain.
authors.affiliation: Center for Genomics Research, Karolinska Institutet, 171 77, Stockholm, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Salmi
authors.forename: B S
authors.initials: BS
authors.lastname: Sproat
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
authors.forename: R
authors.initials: R
authors.lastname: Hale
authors.forename: N
authors.initials: N
authors.lastname: Avery
authors.forename: J
authors.initials: J
authors.lastname: Kela
authors.forename: C
authors.initials: C
authors.lastname: Wahlestedt
mesh_terms: D000818:Animals; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens; D019257:Quinpirole / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D016337:RNA, Catalytic / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D016337:RNA, Catalytic; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D013469:Sulpiride