[The allergenic and immunotropic properties of the preparation pantohematogen].
Experiments on CBA/Ca Lac mice showed that pantohematogen, a drug prepared from whole blood of Siberian deer, wapiti, and deer, when administered in a course in doses under study and in chosen conditions of the experiment does not possess allergenic and immunotoxic properties. The immunomodulating properties of the drug were characterized by marked stimulation of macrophage phagocytic activity and, under definite conditions, by activation of formation of antibody-producing cells in the spleen of mice immunized with sheep erythrocytes.
Ratner
G M
GM
Laboratory of Immunopharmacology and Toxicology of Antitumor Drugs, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Khlusova
M Iu
MIu
Stakheeva
M N
MN
Stepovaia
E A
EA
Sherstoboev
E Iu
EIu
Suslov
N I
NI
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D003670:Deer / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007114:Immunization / Q000379:methods; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000485:Allergens