A role of glucocorticoid receptors in the guinea pig vestibular system.
To investigate glucocorticoid receptor (GR) function in the vestibular periphery, GR antagonist RU38486 was administered to the guinea pig inner ear by osmotic pump, and we observed post-rotatory nystagmus (PRN) changes as a marker of vestibular function. Ten days after treatment, RU38486 (1 mM) resulted in ipsilateral vestibule hyperexcitability in response to rotation stimulation. This effect was dose-dependent. These data indicate that steroid hormones may play an important role in maintaining vestibular function.
Shimogori
H
H
Department of Otolaryngology, Yamaguchi University School of Medicine, Japan. shimo-h@po.cc.yamaguchi-u.ac.jp
Yamashita
H
H
Watanabe
T
T
Nakamura
S
S
D000818:Animals; D007758:Ear, Inner / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology*; D009760:Nystagmus, Physiologic / Q000187:drug effects / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology
D006727:Hormone Antagonists; D011965:Receptors, Glucocorticoid; D015735:Mifepristone