Near-tetraploid minimally differentiated acute myeloid leukemia with extensive erythrophagocytosis by leukemic blasts.
Numerical change of chromosomes is common in acute myeloid leukemia (AML). However, a chromosome number as high as near-tetraploidy is very rare, especially in minimally differentiated AML (AML-M0). Erythrophagocytosis by reactive or malignant histiocytes is common in malignant hematological diseases; however, erythrophagocytosis by leukemic blasts is also very rare, especially in AML-M0. We report here the first case of AML-M0 with both of these unique characteristics: a near-tetraploid karyotype and erythrophagocytosis by leukemic blasts.
Yeh
S P
SP
Division of Hematology-Oncology, Department of Internal Medicine, China Medical College Hospital, 2 Yu Teh Road, Taichung, Taiwan. t5408@hpd.cmch.org.tw
Wang
Y
Y
Su
J
J
Hsueh
E
E
Yu
M
M
Wu
H
H
D000208:Acute Disease; D000328:Adult; D000782:Aneuploidy; D001752:Blast Crisis / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D008297:Male; D010587:Phagocytosis / Q000502:physiology*