title: [Inherited factor VII deficiency and pregnancy. Apropos of 1 case].
abstract: Hereditary factor VII deficiency is a rare autosomal recessive condition. Factor VII's level elevates during pregnancy in normal patients, as well in deficient individuals for some authors. Various treatments (fresh frozen plasma, prothrombin complex or factor VII concentrate) have been used to lessen the peri-partum hemorrhage in those factor VII-deficient pregnant women. We report the case of a pregnant woman presenting a factor VII deficiency (level 4%), without variation of level during her pregnancy. The single infusion of factor VII concentrate, prior to delivery, has elevated factor VII's level at 17% and has likely permitted minimal post-partum bleeding. The peripartum management of factor VII deficiency is discussed.
authors.affiliation: Laboratoire de Biochimie-Hormonologie-Hémostase, CHI Robert Ballanger, Aulnay-sous-Bois.
authors.forename: T
authors.initials: T
authors.lastname: Soni
authors.forename: L
authors.initials: L
authors.lastname: Abecassis
authors.forename: Y
authors.initials: Y
authors.lastname: Chitrit
authors.forename: M C
authors.initials: MC
authors.lastname: Boulanger
authors.forename: F
authors.initials: F
authors.lastname: le Bihan-Augereau
mesh_terms: D000328:Adult; D005167:Factor VII / Q000008:administration & dosage / Q000627:therapeutic use; D005168:Factor VII Deficiency / Q000628:therapy*; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000517:prevention & control; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic
chemical_list: D005167:Factor VII