TGF beta-related pathways. Roles in Caenorhabditis elegans development.
Genetic and molecular analysis in Caenorhabditis elegans has produced new insights into how TGF beta-related pathways transduce signals and the developmental processes in which they function. These pathways are essential regulators of dauer formation, body-size determination, male copulatory structures and axonal guidance. Here, we review the insights that have come from standard molecular genetic experiments and discuss how the recently completed genome sequence has contributed to our understanding of these pathways.
Patterson
G I
GI
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. patterson@waksman.rutgers.edu
Padgett
R W
RW
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008297:Male; D015398:Signal Transduction / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics* / Q000378:metabolism
D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D015801:Helminth Proteins; D016212:Transforming Growth Factor beta