Adrenomedullin levels in normal and preeclamptic pregnancy at term.
OBJECTIVE
To describe maternal plasma levels of adrenomedullin (AM), a hypotensive and natriuretic peptide, in normal and preeclamptic women at term.


METHODS
Maternal plasma AM levels were determined in 13 preeclamptic and 15 normotensive primigravidas by radioimmunoassay. Plasma samples were obtained with the patients in the lateral recumbent position before the administration of any medications.


RESULTS
Women with preeclampsia had significantly elevated AM levels when compared with normotensive controls (42.3 +/- 10.5 pg/mL versus 16.9 +/- 3.1 pg/mL, P < .011).


CONCLUSIONS
In this pilot study, AM levels were significantly increased at term in preeclamptic women.
Lauria
M R
MR
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA. michele.lauria@hitchcock.org
Standley
C A
CA
Sorokin
Y
Y
Yelian
F D
FD
Cotton
D B
DB
D000293:Adolescent; D053607:Adrenomedullin; D000328:Adult; D005260:Female; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood; D010455:Peptides / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values
D010455:Peptides; D053607:Adrenomedullin