title: Postoperative pattern of various hormonal and metabolic variables. A pilot study in patients without complications following cardiac surgery.
abstract: The use of single predictors for threatening postoperative complications are widely accepted. However, a typical pattern of multiple parameters could be more helpful than a single predictor. To study this hypothesis, various variables of normal postoperative changes in patients without postoperative complications were investigated. Secondly, this pattern needs to be compared in the future with those findings in patients with postoperative complications. Blood parameters of 13 patients undergoing cardiovascular surgery without postoperative complications for 24 hours were evaluated. Samples were obtained on the afternoon before the operation and 1, 3, 6, 12 and 24 hours after the end of surgery. At one hour postoperation increased levels of the following parameters were noted: growth hormone (p < 0.0001), glucose (p < 0.0001), insulin (p < 0.001), c-peptide (p < 0.001), lactate (p < 0.002), glutamate (p < 0.0001), aspartate (p < 0.001) and total amino acids (p < 0.05), although the concentration of some amino acids decreased. Three hours postoperatively free fatty acids (p < 0.05) were increased. Total-T3 concentrations were reduced postoperatively. Other parameters were not altered. Most of the parameters returned to normal values during the period of observation.
authors.affiliation: Medizinische Hochschule Hannover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Rümelin
authors.forename: G
authors.initials: G
authors.lastname: Nietgen
authors.forename: M
authors.initials: M
authors.lastname: Pirlich
authors.forename: P
authors.initials: P
authors.lastname: Thum
authors.forename: S
authors.initials: S
authors.lastname: Bischoff
authors.forename: H J
authors.initials: HJ
authors.lastname: Schäfers
authors.forename: A
authors.initials: A
authors.lastname: von zur Mühlen
authors.forename: E
authors.initials: E
authors.lastname: Kirchner
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000097:blood; D001021:Aortic Valve; D001786:Blood Glucose / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011184:Postoperative Period; D012016:Reference Values; D013997:Time Factors
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006728:Hormones