[The immunotropic properties of the deoxyribonucleic acid from Salmonidae milt].
The study of the immunotropic action of DNA from salmon milt showed that it increased the antiinfectious resistance of mice to Escherichia coli and Salmonella enteritidis, stimulated the antibody response to the thymus-dependent corpuscular antigen (sheep erythrocytes), increased the production of the antibody forming cells (AFC) in the murine spleen and intensified the absorptive and digestive activities of the cells of the mononuclear phagocytes. The immunotropic properties of the DNA permitted to broaden the DNA application spectrum with its supplementing by immunodeficiency of various genesis and diseases with phagocytic protection mechanisms. It is quite possible that the salmon milt DNA be used as a food additive.
Besednova
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NN
Research Institute of Epidemiology and Microbiology, Siberian Department, Russian Academy of Medical Sciences, Vladivostok.
Kas'ianenko
Iu I
IuI
Epshteĭn
L M
LM
Gazha
A K
AK
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004247:DNA / Q000008:administration & dosage / Q000276:immunology* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000276:immunology; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D010587:Phagocytosis / Q000187:drug effects; D012487:Salmonidae / Q000276:immunology*; D013094:Spermatozoa / Q000276:immunology*; D013997:Time Factors
D004247:DNA