title: Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain.
abstract: Immunohistochemistry was used to analyze the rat brain distribution of thimet oligopeptidase and neurolysin. Both enzymes appear ubiquitously distributed within the entire rat brain. However, neuronal perikarya and processes stained for neurolysin, while intense nuclear labeling was only observed for thimet oligopeptidase. These data suggest that neurolysin and thimet oligopeptidase, endopeptidases sharing several functional and structural similarities, are present in distinctive intracellular compartments in neuronal cells.
authors.affiliation: Department of Histology, Biomedical Sciences Institute, USP, SP, Brazil.
authors.forename: E E
authors.initials: EE
authors.lastname: Massarelli
authors.forename: C A
authors.initials: CA
authors.lastname: Casatti
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: A C
authors.initials: AC
authors.lastname: Camargo
authors.forename: J A
authors.initials: JA
authors.lastname: Bauer
authors.forename: M J
authors.initials: MJ
authors.lastname: Glucksman
authors.forename: J L
authors.initials: JL
authors.lastname: Roberts
authors.forename: S
authors.initials: S
authors.lastname: Hirose
authors.forename: E S
authors.initials: ES
authors.lastname: Ferro
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D008297:Male; D008666:Metalloendopeptidases / Q000032:analysis*; D009474:Neurons / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008666:Metalloendopeptidases; C022510:thimet oligopeptidase; C062316:neurolysin