title: [Incisional local anesthesia as postoperative pain control after abdominal surgery. A qualitative, systematic review].
abstract: A qualitative systematic review of randomized controlled trials (RCT) of incisional local anaesthesia for the control of postoperative pain after open abdominal operations was performed. Twenty-six studies with data from 1211 patients were considered appropriate for analysis. RCT considered inguinal herniotomy, hysterectomy, cholecystectomy and a variety of surgical procedures. Outcome measures were pain scores, supplementary analgesics and time to first analgesic request. Efficacy was estimated by significant difference (p < 0.05) as reported in the original investigation. All trials of herniotomy showed a 2-7 hour lasting, clinically relevant, improved pain relief. Five of eight cholecystectomy trials showed significant differences but in three studies of questionable clinical importance and validity. In other procedures results were inconsistent and in some cases of minor clinical importance. Except for herniotomy there is a lack of evidence for effect of incisional local anaesthesia on postoperative pain and further standardized studies are needed before recommendations can be made.
authors.affiliation: Anaestesiologisk/intensiv afdeling 104, Amtssygehuset i Herlev. stmi@herlevhosp.kbhamt.dk
authors.forename: S
authors.initials: S
authors.lastname: Møiniche
authors.forename: S S
authors.initials: SS
authors.lastname: Mikkelsen
authors.forename: J
authors.initials: J
authors.lastname: Wetterslev
authors.forename: J B
authors.initials: JB
authors.lastname: Dahl
mesh_terms: D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002763:Cholecystectomy / Q000009:adverse effects; D005260:Female; D005767:Gastrointestinal Diseases / Q000601:surgery; D005831:Genital Diseases, Female / Q000601:surgery; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic
chemical_list: D000779:Anesthetics, Local