Carrageenans from chilean samples of Stenogramme interrupta (Phyllophoraceae): structural analysis and biological activity.
Carrageenans extracted from cystocarpic and tetrasporic Stenogramme interrupta were analysed by chemical and spectroscopic methods. The carrageenan from cystocarpic plants is composed predominantly of 0.5 M KCl-insoluble and 1 M KCl-soluble fractions. The insoluble fraction contained iota-carrageenan as the major component with alpha-carrageenan and pyruvated carrageenan as minor components. The soluble fraction is highly heterogeneous and did not contain the precursors mu- and nu-carrageenans. The polysaccharide from tetrasporic plants is composed of zeta- and lambda-carrageenans, and low sulfated galactans. It is soluble in KCl and partly cyclized by alkaline treatment. The antiviral and anticoagulant properties of the insoluble polysaccharide fraction from cystocarpic S. interrupta and the polysaccharide from tetrasporic S. interrupta are reported the results of which suggest promising antiherpetic activity.
Cáceres
P J
PJ
Departamento de Ciencias Químicas, Universidad de Santiago de Chile.
Carlucci
M J
MJ
Damonte
E B
EB
Matsuhiro
B
B
Zuñiga
E A
EA
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D002351:Carrageenan / Q000737:chemistry* / Q000494:pharmacology; D002677:Chile; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D012624:Seaweed / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000925:Anticoagulants; D000998:Antiviral Agents; D002351:Carrageenan