title: Preintervention lesion remodelling affects operative mechanisms of balloon optimised directional coronary atherectomy procedures: a volumetric study with three dimensional intravascular ultrasound.
abstract: OBJECTIVE
  To classify atherosclerotic coronary lesions on the basis of adequate or inadequate compensatory vascular enlargement, and to examine changes in lumen, plaque, and vessel volumes during balloon optimised directional coronary atherectomy procedures in relation to the state of adaptive remodelling before the intervention.
  
  
  METHODS
  29 lesion segments in 29 patients were examined with intravascular ultrasound before and after successful balloon optimised directional coronary atherectomy procedures, and a validated volumetric intravascular ultrasound analysis was performed off-line to assess the atherosclerotic lesion remodelling and changes in plaque and vessel volumes that occurred during the intervention. Based on the intravascular ultrasound data, lesions were classified according to whether there was inadequate (group I) or adequate (group II) compensatory enlargement.
  
  
  RESULTS
  There was no significant difference in patient and lesion characteristics between groups I and II (n = 10 and 19), including lesion length and details of the intervention. Quantitative coronary angiographic data were similar for both groups. However, plaque and vessel volumes were significantly smaller in group I than in II. In group I, 9 (4)% (mean (SD)) of the plaque volume was ablated, while in group II 16 (11)% was ablated (p = 0.01). This difference was reflected in a lower lumen volume gain in group I than in group II (46 (18) mm(3) v 80 (49) mm(3) (p < 0.02)).
  
  
  CONCLUSIONS
  Preintervention lesion remodelling has an impact on the operative mechanisms of balloon optimised directional coronary atherectomy procedures. Plaque ablation was found to be particularly low in lesions with inadequate compensatory vascular enlargement.
authors.affiliation: Department of Cardiology, University Hospital Essen, Hufelandstr 55, D-45122 Essen, Germany. von.birgelen@uni-essen.de
authors.forename: C
authors.initials: C
authors.lastname: von Birgelen
authors.forename: G S
authors.initials: GS
authors.lastname: Mintz
authors.forename: E A
authors.initials: EA
authors.lastname: de Vrey
authors.forename: P W
authors.initials: PW
authors.lastname: Serruys
authors.forename: T
authors.initials: T
authors.lastname: Kimura
authors.forename: M
authors.initials: M
authors.lastname: Nobuyoshi
authors.forename: J J
authors.initials: JJ
authors.lastname: Popma
authors.forename: M B
authors.initials: MB
authors.lastname: Leon
authors.forename: R
authors.initials: R
authors.lastname: Erbel
authors.forename: P J
authors.initials: PJ
authors.lastname: de Feyter
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D017225:Atherectomy, Coronary / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018084:Ultrasonography, Interventional