title: Therapy related acute myeloid leukemia after exposure to 5-fluorouracil: a case report.
abstract: Therapy related acute myeloid leukemia occurs after exposure to various cytotoxic agents. Among typical chemotherapeutic agents are the alkylating agents and topoisomerase II inhibitors. This type of leukemia has been reported after the use of antimetabolites. We report here a patient who developed therapy related acute myeloid leukemia secondary to the use of 5-fluorouracil.
authors.affiliation: Hacettepe University, Institute of Oncology, Department of Basic Oncology, Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Turker
authors.forename: N
authors.initials: N
authors.lastname: Güler
mesh_terms: D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology*; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D013274:Stomach Neoplasms / Q000601:surgery
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil