Drug-induced linear IgA bullous dermatosis after vancomycin discontinuance in a patient with renal insufficiency.
Linear IgA bullous dermatosis (LABD) is an autoimmune, subepidermal, vesiculobullous disease that has been commonly associated with the use of vancomycin hydrochloride. Lesions typically appear during vancomycin therapy, 24 hours to 15 days after the first dose. A 65-year-old white man with renal insufficiency developed pruritic, tense bullae on the right chest, right medial arm, right flank, abdomen, and right upper thigh 14 days after his last dose of vancomycin. Histopathologic examination and immunofluorescence studies were diagnostic of LABD. Vancomycin-related LABD may appear as long as 2 weeks after the drug is discontinued.
Klein
P A
PA
Division of Dermatology, Department of Medicine, University of Louisville, Kentucky, USA.
Callen
J P
JP
D000368:Aged; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000175:diagnosis; D001706:Biopsy; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D008297:Male; D051437:Renal Insufficiency / Q000150:complications*; D012867:Skin / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000175:diagnosis; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors; D014640:Vancomycin / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D007070:Immunoglobulin A; D014640:Vancomycin