title: The effects of development of a food-related operant reflex on the receptor binding of glutamate in the rat brain.
abstract: Receptor binding of glutamate was studied in the striatum, hippocampus, and cerebral cortex of rats with different abilities to acquire an operant food-related reflex in a Skinner box. The striatum of rapidly-learning rats and rats unable to learn showed significantly higher levels of glutamate binding than controls were not trained in the Skinner box (p < 0.05). Striatal receptor binding of glutamate in slow-learning rats was lower than that in rapidly-learning rats and rats which were unable to learn (p < 0.05). In the hippocampus, all groups of rats (rapidly-learning, slow-learning, and those unable to learn) showed increased receptor binding of glutamate as compared with controls (p < 0.05), in the cerebral cortex, there was a significant decrease in glutamate binding as compared with controls in all groups of animals subjected to training (p < 0.05).
authors.affiliation: Department of Normal Physiology, I. P. Pavlov St. Petersburg State Medical University, Russia.
authors.forename: I V
authors.initials: IV
authors.lastname: Karpova
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D002118:Calcium / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005502:Food; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology; D007700:Kinetics; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D017072:Neostriatum / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017470:Receptors, Glutamate / Q000502:physiology*; D012964:Sodium / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
chemical_list: D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D017470:Receptors, Glutamate; D012964:Sodium; D002118:Calcium