Thyroid hormones regulate lipid metabolism in a teleost Anabas testudineus (Bloch).
We compared the long-term action of 3,5,3'-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2) on lipid metabolism in a teleost Anabas testudineus. Among the six groups of animals used in this experiment, except for the control group, all received 6-propylthiouracil (6-PTU) to create a hypothyroid state in order to analyse the action of iodothyronines on lipid metabolism. Injections of 6-PTU reduced T3 concentration in the circulation by 79.6% and injections of iodothyronines enhanced the level of T3 in the plasma, and a maximum increase was observed in T3 (500 ng)-treated specimens. Analysis of lipogenic enzymes in liver and heart showed that a tissue-specific variation exists in the action of thyroid hormones and, in many cases, activity is higher in T2-treated groups. Analysis of various lipid classes showed that long-term administration of T2 is also effective in producing a comparable effect with that of T3 on lipid metabolism.
Varghese
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S
Department of Zoology, Endocrinology and Biochemistry Division, University of Kerala, India.
Oommen
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OV
D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D004104:Diiodothyronines / Q000378:metabolism* / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D010471:Perches / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism; D011441:Propylthiouracil / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism* / Q000494:pharmacology
D013956:Antithyroid Agents; D004104:Diiodothyronines; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D014284:Triiodothyronine; C030103:3,5-diiodothyronine; D011441:Propylthiouracil; D002784:Cholesterol; D007521:Isocitrate Dehydrogenase; C039355:isocitrate dehydrogenase (NADP+); D005954:Glucosephosphate Dehydrogenase