[Hepatobiliary cystadenoma with mesenchymal stroma: a hormone dependent tumor. Report of five cases with immunohistochemical study of hormone receptors].
Hepatobiliary cystadenomas with mesenchymal stroma are rare neoplasms, which occur only in females; they have a strong tendency to recur and a potential for malignant transformation. Microscopic features are characteristic but clinical findings are highly variable and laboratory data non specific. We report 5 cases with immunohistochemical study, showing the characteristics of mesenchymal stromal cells: myofibroblastic phenotype and expression of progesterone receptors in all cases and estrogen receptors in 3 out of 5 cases. These results point out the possible hormonal dependance of this tumor.
Pedram-Canihac
M
M
Service d'Anatomie Pathologique, Hôpital Pellegrin, place Amélie-Raba-Léon, 33076 Bordeaux.
Le Bail
B
B
Rivel
J
J
Blanc
J
J
Saric
J
J
Bioulac-Sage
P
P
D000328:Adult; D001661:Biliary Tract Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D003537:Cystadenoma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D017154:Stromal Cells / Q000473:pathology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone