[Efficacy of methylprednisolone pulse and mild hypothermia therapies in patients with acute encephalopathy].
Five patients with acute encephalopathy underwent methylprednisolone pulse (mPSL-P), hypothermia and their combination therapies (3 cases, 1 case and 1 case, respectively), with excellent outcome. Two cases with severe brain edema survived. One had severe brain damage as a sequelae. The remaining one recovered well after the combination therapy with mPSL-p and mild hypothermia, despite complete obstruction of the fourth ventricle on the first CT scan; the sequelae, hemiplegia and intelligent disturbance, was only mild. Four patients who received mPSL-P therapy within 6 hours after the onset of CNS symptoms recovered well though one was left with epilepsy. These results indicate that mPSL-P and/or hypothermia therapy will be chosen as the treatment of acute encephalopathy.
Kimura
S
S
Department of Pediatrics, Urafune Hospital of Yokohama City University, School of Medicine.
Ohtsuki
N
N
Adachi
K
K
Nezu
A
A
Aihara
Y
Y
D000208:Acute Disease; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004660:Encephalitis / Q000628:therapy*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D020551:Pulse Therapy, Drug; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone