Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoter.
Our earlier studies have shown that the flavonoid hesperidin inhibits tumor promotion in a two stage skin tumorigenesis protocol in CD-1 mice. In this study hesperidin's significant protection (p < 0.0001) against 12-0-tetradecanoylphorbol-13-acetate (TPA) induced edema in CD-1 mouse ear will be presented. Hesperidin also afforded significant protection against TPA induced hyperplasia in the dorsal skin through multiple application prior to TPA. Protection by hesperidin was 93% of the epidermal thickness and 100% of the vertical cell layers. The data also indicate the protective effect of hesperidin against TPA caused infiltration of neutrophils by 73%. These results suggest that hesperidin may possess potential as chemopreventive agent against tumor promoter induced inflammation and hyperplasia.
Koyuncu
H
H
Istanbul University, Department of Molecular Medicine, Capa, Istanbul, Turkey. Koyuncuh@doruk.com.tr
Berkarda
B
B
Baykut
F
F
Soybir
G
G
Alatli
C
C
Gül
H
H
Altun
M
M
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006569:Hesperidin / Q000494:pharmacology*; D051379:Mice; D012867:Skin / Q000187:drug effects* / Q000473:pathology
D002273:Carcinogens; D006569:Hesperidin