Acylated flavonol glycosides from the flower of Inula britannica.
Three new acylated flavonol glycosides, patuletin 7-O-(6' '-isobutyryl)glucoside (1), patuletin 7-O-[6' '-(2-methylbutyryl)]glucoside (2), and patuletin 7-O-(6' '-isovaleryl)glucoside (3), were isolated from the n-BuOH extract of Inula britannica flowers by bioassay-guided fractionation, together with other known flavonoids. The structures were elucidated by 1D and 2D NMR, FABMS, and other spectral analyses. The eight flavonoids, including new compounds (1-3), patulitrin (7), nepitrin (8), axillarin (10), patuletin (11), and luteolin (12), showed profound antioxidant activity in DPPH assay and cytochrome-c reduction assay using HL-60 cell culture system.
Park
E J
EJ
College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Kim
Y
Y
Kim
J
J
D000215:Acylation; D005419:Flavonoids / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D038143:Inula / Q000737:chemistry*; D015394:Molecular Structure; D013057:Spectrum Analysis
D005419:Flavonoids; D006027:Glycosides