MARs of antigen receptor and co-receptor genes.
MARs are cis-acting DNA sequences that function both negatively and positively in conjunction with transcriptional enhancers to regulate antigen receptor and co-receptor genes. Evidence exists that certain tissue-specific nuclear proteins are involved in this regulation, including SATB1, Bright, and Cux/CDP, possibly by modulating intranuclear gene location, histone acetylation, DNA methylation, and/or nucleosome positioning.
Scheuermann
R H
RH
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Garrard
W T
WT
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D019175:DNA Methylation; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D015530:Nuclear Matrix / Q000235:genetics*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D014158:Transcription, Genetic
D011948:Receptors, Antigen, T-Cell; D004247:DNA