title: A role of glucocorticoid receptors in the guinea pig vestibular system.
abstract: To investigate glucocorticoid receptor (GR) function in the vestibular periphery, GR antagonist RU38486 was administered to the guinea pig inner ear by osmotic pump, and we observed post-rotatory nystagmus (PRN) changes as a marker of vestibular function. Ten days after treatment, RU38486 (1 mM) resulted in ipsilateral vestibule hyperexcitability in response to rotation stimulation. This effect was dose-dependent. These data indicate that steroid hormones may play an important role in maintaining vestibular function.
authors.affiliation: Department of Otolaryngology, Yamaguchi University School of Medicine, Japan. shimo-h@po.cc.yamaguchi-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Shimogori
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D007758:Ear, Inner / Q000187:drug effects* / Q000502:physiology; D006168:Guinea Pigs; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology*; D009760:Nystagmus, Physiologic / Q000187:drug effects / Q000502:physiology; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000502:physiology
chemical_list: D006727:Hormone Antagonists; D011965:Receptors, Glucocorticoid; D015735:Mifepristone