title: The relation between dopamine D2 receptor density and personality: preliminary evidence from the NEO personality inventory-revised.
abstract: OBJECTIVE
  To examine the relation between dopamine (DA) D2 receptor-specific binding and personality, we assessed the relation between DA D2 binding and the NEO Personality Inventory-Revised (NEO PI-R).
  
  
  BACKGROUND
  Previous studies have demonstrated a relation between DA D2 receptor-specific binding and a personality trait involving personal detachment as defined by the Karolinska Scales of Personality: A subsequent study using a different measure of personal detachment failed to replicate this finding, suggesting that metric properties of the personality scale may be important. To further examine this issue, we assessed the relation between DA D2 binding and a third personality measure, the NEO PI-R.
  
  
  METHODS
  Eighteen adult subjects completed the NEO PI-R and participated in an 11C-raclopride positron emission tomography study to quantify striatal DA D2 receptor binding.
  
  
  RESULTS
  We did not find a significant relation between binding and detachment-like traits on the NEO PI-R; however, we found a significant relation between DA D2 receptor binding and the NEO PI-R personality facet of Depression (r = 0.75, p <0.0001).
  
  
  CONCLUSIONS
  The results fail to replicate the findings of previous studies reporting an association between DA D2 receptor density and personal detachment, suggesting that the relation is relatively specific to the trait defined by the Karolinska Scales of Personality. The relation between a nonclinical personality trait of depression and DA D2 binding, if replicated, may help to elucidate the role of dopamine in depression.
authors.affiliation: Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Kestler
authors.forename: A K
authors.initials: AK
authors.lastname: Malhotra
authors.forename: C
authors.initials: C
authors.lastname: Finch
authors.forename: C
authors.initials: C
authors.lastname: Adler
authors.forename: A
authors.initials: A
authors.lastname: Breier
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009769:Object Attachment; D010555:Personality Inventory; D011594:Psychometrics; D020891:Raclopride / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000502:physiology*; D012016:Reference Values; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed
chemical_list: D017448:Receptors, Dopamine D2; D020891:Raclopride