15-month efficacy of maternal oral zidovudine to decrease vertical transmission of HIV-1 in breastfed African children. DITRAME ANRS 049 Study Group.
In a randomised, double-blind comparison of a maternal short regimen of oral zidovudine with placebo in West Africa the 15-month efficacy of zidovudine in preventing mother-to-child transmission of HIV-1 infection was estimated at 30% (95% CI -2 to 52).
D000284:Administration, Oral; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001942:Breast Feeding; D002050:Burkina Faso; D007560:Cote d'Ivoire; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control / Q000635:transmission*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D016896:Treatment Outcome; D015215:Zidovudine / Q000008:administration & dosage* / Q000009:adverse effects
D019380:Anti-HIV Agents; D015215:Zidovudine