Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats.
The injection of a dopamine D(2) receptor hammerhead ribozyme (20 microg) once daily for 5 days into the nucleus accumbens of rats resulted in an inhibition of stereotyped sniffing and locomotor activation produced by the selective dopamine D(2) receptor agonist, quinpirole (0.4 mg kg(-1) s.c.). The results suggest that ribozymes may be useful in the study of in vivo gene function in the brain.
Salmi
P
P
Center for Genomics Research, Karolinska Institutet, 171 77, Stockholm, Sweden.
Sproat
B S
BS
Ludwig
J
J
Hale
R
R
Avery
N
N
Kela
J
J
Wahlestedt
C
C
D000818:Animals; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens; D019257:Quinpirole / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D016337:RNA, Catalytic / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013469:Sulpiride / Q000008:administration & dosage / Q000494:pharmacology
D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D016337:RNA, Catalytic; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D013469:Sulpiride