Association of Chlamydia pneumoniae infection with diabetic nephropathy.
We evaluated the association of Chlamydia pneumoniae (CP) infection with progression of diabetic nephropathy. Type 2 diabetic patients (60) were divided into two groups, those with incipient nephropathy and those with advanced nephropathy, based on the severity of diffuse glomerular lesions using Gellman's criteria. Type 2 (34) diabetic patients without nephropathy (normoalbuminuria) and 59 nondiabetics served as control groups. Serum IgG-antibody against CP was measured using ELISA. CP antibody was detected in 45.8% of nondiabetic controls, in 47.1% of diabetic patients without nephropathy, in 52.6% of diabetic patients with incipient nephropathy, and 78% of diabetic patients with advanced nephropathy. There was 4.22-fold increase in the risk of advanced nephropathy associated with the presence of CP antibody. Our findings indicate an association between chronic CP infection and advanced diabetic nephropathy.
Kanauchi
M
M
First Department of Internal Medicine, Nara Medical University, Japan.
Kawano
T
T
Dohi
K
K
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D001706:Biopsy; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000276:immunology; D016993:Chlamydophila pneumoniae; D003928:Diabetic Nephropathies / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G