title: Antimutagenicity of a suberin extract from Quercus suber cork.
abstract: The possible protective effect of a suberin extract from Quercus suber cork on acridine orange (AO)-, ofloxacin- and UV radiation-induced mutagenicity (bleaching activity) in Euglena gracilis was examined. To our knowledge, the present results are the first attempt to analyse suberin in relation to mutagenicity of some chemicals. Suberin exhibits a significant dose-dependent protective effect against AO-induced mutagenicity and the concentration of 500 micrograms/ml completely eliminates the Euglena-bleaching activity of AO. The mutagenicity of ofloxacin is also significantly reduced in the presence of suberin (125, 250 and 500 micrograms/ml). However, the moderate protective effect of suberin on UV radiation-induced mutagenicity was observed only at concentrations 500 and 1000 micrograms/ml. Our data shows that suberin extract from Q. suber cork possess antimutagenic properties and can be included in the group of natural antimutagens acting in a desmutagenic manner.
authors.affiliation: Institute of Cell Biology, Faculty of Science, Comenius University, Bratislava, Slovak Republic. krizkova@m2.fedu.uniba.sk
authors.forename: L
authors.initials: L
authors.lastname: Krizková
authors.forename: M H
authors.initials: MH
authors.lastname: Lopes
authors.forename: J
authors.initials: J
authors.lastname: Polónyi
authors.forename: A
authors.initials: A
authors.lastname: Belicová
authors.forename: J
authors.initials: J
authors.lastname: Dobias
authors.forename: L
authors.initials: L
authors.lastname: Ebringer
mesh_terms: D000165:Acridine Orange / Q000633:toxicity; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D005056:Euglena gracilis / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D008055:Lipids; D008563:Membrane Lipids / Q000494:pharmacology*; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity; D015242:Ofloxacin / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D018520:Plant Shoots / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000378:metabolism; D014197:Trees / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D016587:Antimutagenic Agents; D008055:Lipids; D008563:Membrane Lipids; D009153:Mutagens; D010936:Plant Extracts; D013481:Superoxides; C065875:suberin; D015242:Ofloxacin; D000165:Acridine Orange