A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity.
A new biflavonoid named pancibiflavonol (1) was isolated from an EtOH extract of the stem bark of Calophyllum panciflorum, along with six known biflavonoids, and its structure was elucidated by spectroscopic methods. These biflavonoids all exhibited significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus early antigen activation in Raji cells.
Ito
C
C
Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Itoigawa
M
M
Miyamoto
Y
Y
Rao
K S
KS
Takayasu
J
J
Okuda
Y
Y
Mukainaka
T
T
Tokuda
H
H
Nishino
H
H
Furukawa
H
H
D000970:Antineoplastic Agents / Q000302:isolation & purification*; D002460:Cell Line; D002472:Cell Transformation, Viral / Q000187:drug effects; D005419:Flavonoids / Q000302:isolation & purification*; D044948:Flavonols; D004854:Herpesvirus 4, Human; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D014197:Trees / Q000737:chemistry*
D000970:Antineoplastic Agents; D005419:Flavonoids; D044948:Flavonols; C404384:pancibiflavonol