title: Experimental hypocalcemia induced by hemodialysis in goats.
abstract: To evaluate whether hemodialysis with a dialysate containing no calcium (Ca-free HD) can induce hypocalcemia and restore the clinical signs and blood biochemical changes in naturally occurred hypocalcemic disorder in ruminants, the clinical signs and the changes in plasma electrolytes and minerals concentrations were observed in goats during 6-hr hemodialysis. The four goats received hemodialysis with the dialysate containing calcium (Ca HD), and 10 days later they had Ca-free HD. The plasma ionized Ca (Ca++) and total Ca (TCa) concentrations were not affected by Ca HD, whereas the levels significantly decreased during whole period of Ca-free HD. The Ca++ and TCa concentrations were 0.69+/-0.06 mmol/l and 5.9+/-0.3 mg/dl at 6 hr of Ca-free HD, respectively. The clinical signs observed during Ca-free HD seemed to resemble to those in naturally occurred hypocalcemic cases that were reported previously. Therefore, Ca-free HD was suggested to be one of the possible methods to induce experimental hypocalcemia in ruminants.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamagishi
authors.forename: A
authors.initials: A
authors.lastname: Oishi
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000818:Animals; D001831:Body Temperature; D002122:Calcium Chloride / Q000097:blood / Q000378:metabolism*; D002254:Carbonates / Q000097:blood; D002712:Chlorides / Q000097:blood; D003124:Colorimetry / Q000662:veterinary; D005260:Female; D015511:Goat Diseases / Q000209:etiology*; D006041:Goats; D006339:Heart Rate; D006996:Hypocalcemia / Q000209:etiology / Q000662:veterinary*; D008274:Magnesium / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011188:Potassium / Q000097:blood; D006435:Renal Dialysis / Q000009:adverse effects / Q000662:veterinary*; D012964:Sodium / Q000097:blood; D013054:Spectrophotometry, Atomic / Q000662:veterinary
chemical_list: D002254:Carbonates; D002712:Chlorides; D010758:Phosphorus; D012964:Sodium; D008274:Magnesium; D002122:Calcium Chloride; D011188:Potassium