title: Identification and assay of lamotrigine in human milk with gas chromatography and densitometry.
abstract: Conditions necessary for isolation and assay of lamotrigine in the human milk with gas chromatography in the range of concentrations 2-20 micrograms/ml, and densitometry in the range of 2-10 micrograms/ml are discussed. Lamotrigine was extracted with methylene chloride from the alkaline solution. In gas chromatography capillary column DB-17, flame-ionizing detector, and octacozanole as the internal standard have been used. Densitometric measurements have been performed at 217 nm.
authors.affiliation: Department of Chemical Analysis, Drug Institute, Warsaw, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Wyszomirska
authors.forename: K
authors.initials: K
authors.lastname: Czerwińska
mesh_terms: D000927:Anticonvulsants / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods*; D003720:Densitometry / Q000379:methods; D006801:Humans; D000077213:Lamotrigine; D008895:Milk, Human / Q000737:chemistry*; D014227:Triazines / Q000032:analysis*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine