Role of the enteric nervous system in the fluid and electrolyte secretion of rotavirus diarrhea.
The mechanism underlying the intestinal fluid loss in rotavirus diarrhea, which often afflicts children in developing countries, is not known. One hypothesis is that the rotavirus evokes intestinal fluid and electrolyte secretion by activation of the nervous system in the intestinal wall, the enteric nervous system (ENS). Four different drugs that inhibit ENS functions were used to obtain experimental evidence for this hypothesis in mice in vitro and in vivo. The involvement of the ENS in rotavirus diarrhea indicates potential sites of action for drugs in the treatment of the disease.
Lundgren
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Department of Physiology, Göteborg University, Box 432, S-405 30 Göteborg, Sweden. ove.lundgren@fysiologi.gu.se
Peregrin
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Persson
K
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Kordasti
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Uhnoo
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Svensson
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D000818:Animals; D000831:Animals, Newborn; D001834:Body Water / Q000378:metabolism*; D003967:Diarrhea / Q000188:drug therapy / Q000503:physiopathology*; D004573:Electrolytes / Q000378:metabolism*; D017615:Enteric Nervous System / Q000187:drug effects / Q000503:physiopathology*; D018738:Hexamethonium / Q000494:pharmacology; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D007421:Intestine, Small / Q000294:innervation; D008012:Lidocaine / Q000494:pharmacology; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D018733:Nicotinic Antagonists / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D012400:Rotavirus Infections / Q000188:drug therapy / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000187:drug effects; D013779:Tetrodotoxin / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology
D004573:Electrolytes; D018733:Nicotinic Antagonists; D018738:Hexamethonium; D013779:Tetrodotoxin; D008464:Mecamylamine; D008012:Lidocaine; D013806:Theophylline