title: Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy.
abstract: Autoantibodies to the heat shock protein 90 (Hsp 90) have been reported as prognostic marker in breast cancer patients. Sera from 20 high-grade osteosarcoma patients were tested at the time of diagnosis by enzyme-linked immunosorbent assay. Presence of anti-Hsp90 antibodies correlated with a better response to neoadjuvant chemotherapy (P < 0.01), whereas the absence correlated with development of metastases. These data suggest that anti-Hsp90 antibodies might be of predictive value in human osteosarcoma.
authors.affiliation: Department of Orthopedics, University of Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Trieb
authors.forename: R
authors.initials: R
authors.lastname: Gerth
authors.forename: G
authors.initials: G
authors.lastname: Holzer
authors.forename: J G
authors.initials: JG
authors.lastname: Grohs
authors.forename: P
authors.initials: P
authors.lastname: Berger
authors.forename: R
authors.initials: R
authors.lastname: Kotz
mesh_terms: D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000276:immunology*; D017024:Chemotherapy, Adjuvant; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005266:Femoral Neoplasms / Q000188:drug therapy / Q000276:immunology; D018841:HSP90 Heat-Shock Proteins / Q000276:immunology*; D006801:Humans; D007085:Ilium; D008297:Male; D009363:Neoplasm Proteins / Q000276:immunology*; D012516:Osteosarcoma / Q000188:drug therapy / Q000276:immunology*; D013977:Tibia
chemical_list: D001323:Autoantibodies; D018841:HSP90 Heat-Shock Proteins; D009363:Neoplasm Proteins