Quantitative measurement of oxygen consumption and forearm blood flow in patients with mitochondrial myopathies.
Five patients with chronic progressive external ophthalmoplegia (CPEO) and 27 healthy controls were examined by near-infrared spectroscopy (NIRS) for the non-invasive and direct quantitative measurement of muscle oxygen consumption during rest as well as during static isometric handgrip exercise at 10% of their maximum voluntary contraction. In patients with CPEO, we found a significantly decreased oxygen consumption during exercise, but more remarkably already during rest. Our results suggest that NIRS is able to discriminate between CPEO patients and healthy controls, which makes NIRS a promising tool in the diagnostic work-up of patients suspected of a mitochondrial myopathy.
Van Beekvelt
M C
MC
Neuromuscular Centre Nijmegen, Department of Neurology, University Hospital Nijmegen.
Colier
W N
WN
Wevers
R A
RA
Van Engelen
B G
BG
D000328:Adult; D015444:Exercise / Q000502:physiology; D005260:Female; D005542:Forearm / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017246:Ophthalmoplegia, Chronic Progressive External / Q000097:blood / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D012146:Rest / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000379:methods