Alterations in surface hydrophobicity of Acinetobacter baumannii induced by meropenem.
Six strains of Acinetobacter baumannii out of eleven strains tested revealed a strong hydrophobic character. This was demonstrated by adherence of bacteria to xylene in the range of 90-94%. Changes in surface hydrophobicity of these strains were studied after treatment with meropenem at subinhibitory concentrations (sub-MICs) (1/4, 1/8, 1/16 or 1/32 of the MICs). All strains showed a reduced adherence to xylene after the action of meropenem at 1/4 or 1/16 of the MICs. Hydrophobicity of the treated bacteria was decreased to 1.3-70% (1/16 of the MICs) or to 12-86% (1/4 of the MICs), depending on the strain. A decrease in surface hydrophobicity of three strains was also observed after their exposure to meropenem at 1/8 of the MICs (to 18-71% of the control values). Meropenem at 1/32 of the MICs practically did not affect bacterial hydrophobic properties, with the exception of one strain.
Hostacká
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Institute of Preventive and Clinical Medicine, Bratislava, Slovakia.
D000150:Acinetobacter / Q000187:drug effects* / Q000472:pathogenicity; D001422:Bacterial Adhesion / Q000187:drug effects; D004352:Drug Resistance, Microbial; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013499:Surface Properties / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*; D014992:Xylenes / Q000378:metabolism
D013845:Thienamycins; D014992:Xylenes; D000077731:Meropenem