title: An analysis of relative costs and potential benefits of different policies for antenatal screening for beta thalassaemia trait and variant haemoglobins.
abstract: OBJECTIVE
  To investigate the costs and potential benefits of different policies for antenatal screening for haemoglobinopathies in two multiethnic London communities.
  
  
  METHODS
  1000 consecutive antenatal patient samples referred to each of two London teaching hospital laboratories for haemoglobinopathy testing were investigated using the standard procedures of the laboratory in question. When the standard procedures did not include high performance liquid chromatography (HPLC), this technique was added, in order to assess its diagnostic value and cost-effectiveness. A comparison was made between the costs and potential benefits of universal testing for variant haemoglobins and beta thalassaemia trait using HPLC and the costs and potential benefits of universal testing for variant haemoglobins and selective testing for beta thalassaemia trait using the mean cell haemoglobin (MCH) as a screening test and less automated techniques than HPLC for definitive diagnosis.
  
  
  RESULTS
  The costs of the two policies were found to be comparable, as the higher reagent/instrument costs of HPLC were offset by the lower labour costs. Universal testing of 2000 consecutive samples did not disclose any extra cases of beta thalassaemia trait which would not have been detected by universal screening and selective testing. However, six patients were found to have a haemoglobin A2 variant which can interfere with the diagnosis of beta thalassaemia trait.
  
  
  CONCLUSIONS
  The introduction of universal testing by HPLC into British laboratories could be cost neutral and has potential benefits. If a higher cost is accepted then the greater degree of automation could be used to release skilled staff for other tasks within the laboratory.
authors.affiliation: Department of Haematology, St Mary's Hospital, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Phelan
authors.forename: B J
authors.initials: BJ
authors.lastname: Bain
authors.forename: D
authors.initials: D
authors.lastname: Roper
authors.forename: C
authors.initials: C
authors.lastname: Jury
authors.forename: K
authors.initials: K
authors.lastname: Bain
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000191:economics; D003362:Cost-Benefit Analysis; D004909:Erythrocyte Indices; D005260:Female; D006453:Hemoglobinopathies / Q000175:diagnosis* / Q000208:ethnology; D006801:Humans; D008403:Mass Screening / Q000191:economics* / Q000379:methods; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000208:ethnology; D011296:Prenatal Diagnosis / Q000191:economics* / Q000379:methods; D006113:United Kingdom; D017086:beta-Thalassemia / Q000175:diagnosis / Q000208:ethnology