False-positive "poral" cobalt patch test reactions reside in the eccrine acrosyringium.
Seventy (32%) of 222 patients patch tested in our contact dermatitis clinic from 1993 to 1995 had irritant reactions to cobalt. These reactions were "poral" and seemed to reflect a unique and probably toxic effect of cobalt on the acrosyringium. The reactions are neither follicular nor petechial and we believe they are not allergic. The histopathology of the reactions is described in detail.
Storrs
F J
FJ
Department of Dermatology (L468), Oregon Health Sciences University, Portland 97201-3098, USA.
White
C R
CR
D003035:Cobalt / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000473:pathology*; D003937:Diagnosis, Differential; D004439:Eccrine Glands / Q000187:drug effects* / Q000473:pathology; D005189:False Positive Reactions; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests
D007509:Irritants; D003035:Cobalt; C029938:nickel sulfate; C025913:cobaltous nitrate; D009532:Nickel; C018021:cobaltous chloride; C026305:cobalt sulfate