title: A comparison of the side effects of prilocaine with felypressin and lignocaine with adrenaline in large loop excision of the transformation zone of the cervix: results of a randomised trial.
abstract: OBJECTIVE
  To test the hypothesis that prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline when performing large loop excision of the transformation zone of the cervix.
  
  
  METHODS
  Randomised trial.
  
  
  METHODS
  Colposcopy clinic in a large district general hospital.
  
  
  METHODS
  Two hundred consecutive women undergoing large loop excision of the transformation zone of the cervix.
  
  
  METHODS
  Two different local anaesthetic combinations (prilocaine with felypressin and lignocaine with adrenaline) were compared in women undergoing large loop excision of the transformation zone. Prospective collection of clinical and treatment data was undertaken with scoring using an ordinal scale of pain experienced by the women during the procedure. Peri-operative blood loss and any side effects were also recorded.
  
  
  METHODS
  Side effects associated with the local anaesthetic agents.
  
  
  RESULTS
  Lignocaine with adrenaline resulted in less blood loss (P = 0.006) but was more likely to cause side effects, such as feeling faint (P = 0.017) and shaking (P < 0.001).
  
  
  CONCLUSIONS
  Prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline and is therefore the preferred local anaesthetic combination for large loop excision of the transformation zone.
authors.affiliation: Academic Department of Obstetrics and Gynaecology, North Staffordshire Hospital Trust, Stoke-on-Trent, Staffordshire, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Howells
authors.forename: H
authors.initials: H
authors.lastname: Tucker
authors.forename: J
authors.initials: J
authors.lastname: Millinship
authors.forename: J F
authors.initials: JF
authors.lastname: Shroff
authors.forename: K K
authors.initials: KK
authors.lastname: Dhar
authors.forename: P W
authors.initials: PW
authors.lastname: Jones
authors.forename: C W
authors.initials: CW
authors.lastname: Redman
mesh_terms: D000328:Adult; D019162:Anesthetics, Combined / Q000009:adverse effects; D000779:Anesthetics, Local / Q000009:adverse effects*; D003127:Colposcopy / Q000379:methods; D004837:Epinephrine / Q000009:adverse effects*; D005259:Felypressin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011318:Prilocaine / Q000009:adverse effects*; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000601:surgery*; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
chemical_list: D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D011318:Prilocaine; D005259:Felypressin; D004837:Epinephrine