title: Effects of MS-8209, an amphotericin B derivative, on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages.
abstract: Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-alpha) mRNA expression and TNF-alpha production and consequently HIV replication in human macrophages. These effects confirm the pharmacological risk associated with the administration of amphotericin B or its derivatives to HIV-infected patients.
authors.affiliation: CEA, Service de Neurovirologie, DSV/DRM, CRSSA, IPSC, Fontenay aux Roses, Paris, France. clayette@dsvidf.cea.fr
authors.forename: P
authors.initials: P
authors.lastname: Clayette
authors.forename: M
authors.initials: M
authors.lastname: Martin
authors.forename: V
authors.initials: V
authors.lastname: Beringue
authors.forename: N
authors.initials: N
authors.lastname: Dereuddre-Bosquet
authors.forename: K T
authors.initials: KT
authors.lastname: Adjou
authors.forename: M
authors.initials: M
authors.lastname: Seman
authors.forename: D
authors.initials: D
authors.lastname: Dormont
mesh_terms: D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000821:virology*; D012333:RNA, Messenger / Q000096:biosynthesis; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; C074660:MS 8209; D000666:Amphotericin B