Pilot MR evaluation of pharmacokinetics and relaxivity of specific blood pool agents for MR angiography.
OBJECTIVE
To evaluate the use of two new blood pool contrast agents (P760, P775) compared with a low-molecular-weight gadolinium chelate in MR angiography.


METHODS
The r1 efficiency of P760 was evaluated in vitro at 1.5 T; 3D abdominal contrast-enhanced MR angiography with qualitative analysis was compared in four rabbits after injection of incremental doses of P760 and in one rabbit after Gd-DOTA. A dynamic MR study was performed using a 2D T1-weighted turbo-flash MR sequence after injection of P760, P775, and Gd-DOTA. Each compound was tested at equivalent doses in three rabbits to assess r1 efficiency. Quantitative analysis of signal intensity in the aorta, the inferior vena cava, the renal cortex, and the medulla was performed.


RESULTS
In vitro, the r1 efficiency of P760 was 23.3 mmol(-1) x L x sec(-1) at 1.5 T. Injection of a dose of P760 10 times less than Gd-DOTA allowed similar vessel visualization. The signal intensity peak and first-pass contrast kinetics in the aorta and the inferior vena cava were similar with the three products. Compared with P760 and Gd-DOTA, P775 allowed a greater renal cortex signal intensity at the first pass and a faster decrease on delayed images.


CONCLUSIONS
The superior r1 efficiency of P760 and P775 was confirmed in vitro and in vivo at 1.5 T compared with Gd-DOTA, and P775 proved to be a rapid-clearance blood pool agent.
Marchand
B
B
Creatis UMR CNRS 5515, Lyon, France.
Douek
P C
PC
Benderbous
S
S
Corot
C
C
Canet
E
E
D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics*; D005682:Gadolinium; D006571:Heterocyclic Compounds; D018810:Magnetic Resonance Angiography; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D010865:Pilot Projects; D011817:Rabbits
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C120577:gadolinium compound P760; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium