[The Italian Registry of Bone Marrow Donors: genetic structure and recruitment strategy].
The genetic structure of the Italian bone marrow donor population was analysed by estimating the HLA-A, -B and -DR gene and haplotype frequencies for the total population and for the Italian administrative regions. The haplotype frequencies were used to predict the probability of finding HLA-compatible donors for Italian patients depending on the registry size, and the probability of recruiting in the different Italian regions a donor with a new phenotype. The analysis of these probabilities allows us to propose strategies for donors recruitment in order to increase the phenotypic variability of the registry, then its efficiency.
Rendine
S
S
Servizio di Immunologia dei Trapianti, Ospedale Molinette, Torino.
Barbanti
M
M
Borelli
I
I
Dall'Omo
A M
AM
Roggero
S
S
Sacchi
N
N
Curtoni
E S
ES
D000465:Algorithms; D001853:Bone Marrow / Q000276:immunology; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy; D012042:Registries / Q000706:statistics & numerical data*
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens