The effects of local application of 1% dopamine on intraocular pressure and pupillary diameter.
This paper deals with the experimental results of the effect of 1% dopamine on intraocular pressure, pupillary diameter and hemodynamic parameters after its local application in the rabbit eye. Our results show that locally applied dopamine caused an initial increase of intraocular pressure (IOP) (1 h), followed by its decrease that was the most pronounced 3 hours later. Mydriasis was an immediate effect of dopamine, which persisted until the end of the second hour. There were no changes in blood pressure and heart rate. Although the exact mechanism of dopamine effect on IOP is not known yet, our results point out that this is mainly due to the decrease fo aqueous humor formation.
Aleksić
P
P
Clinic for Eye Diseases, Military Medical Academy, Belgrade.
Durović
B
B
Raicević
R
R
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011680:Pupil / Q000187:drug effects*; D011817:Rabbits
D009883:Ophthalmic Solutions; D004298:Dopamine