Ibuprofen versus other non-steroidal anti-inflammatory drugs: use in general practice and patient perception.
OBJECTIVE
To investigate whether ibuprofen was as well-regarded by patients as other non-steroidal anti-inflammatory drugs (NSAIDs).


METHODS
Questionnaire sent to 1137 consecutive recipients of an NSAID prescription from 21 doctors in six general practices with computerized records. Patient responses were subsequently linked to data held on the practice records.


METHODS
General practices in and around Nottingham, selected to reflect local variations in number of partners, list size, geographical location, deprivation, prescribing burden and prescribing rate.


METHODS
Unselected patients receiving NSAIDs prescribed for all indications for use.


METHODS
Effectiveness of ibuprofen and other NSAIDs, possible drug related adverse events, patients' overall satisfaction with ibuprofen and other NSAIDs, factors associated with choice of ibuprofen, drug costs of ibuprofen and other NSAIDs.


RESULTS
The main NSAIDs used were ibuprofen, diclofenac and naproxen. Ibuprofen use ranged from 1.0% of prescriptions in one practice to 69.1% in another. Although ibuprofen was generally prescribed in low doses, it was perceived by patients as being as effective as the other NSAIDs used, even after allowing for severity of the pre-treatment condition. Overall, 50.5% of patients rated their NSAID the best treatment they had received for their condition with no differences between individual drugs.


CONCLUSIONS
Ibuprofen is as highly regarded as other NSAIDs when used in similar circumstances. Switching patients to ibuprofen may be a realistic way of reducing financial and medical costs associated with NSAIDs.
Seager
J M
JM
Division of Gastroenterology, University Hospital, Nottingham, UK. cj.hawkey@nottingham.ac.uk
Cullen
D J
DJ
Pearson
G
G
Holmes
S
S
Doherty
M
M
Wilson
J V
JV
Garrud
P
P
Garner
S
S
Maynard
A
A
Logan
R F
RF
Hawkey
C J
CJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D004008:Diclofenac / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D011307:Drug Prescriptions / Q000191:economics / Q000706:statistics & numerical data*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D016347:Medical Records Systems, Computerized; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D017060:Patient Satisfaction / Q000191:economics / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D006113:United Kingdom
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D009288:Naproxen; D007052:Ibuprofen