title: A trial of etomidate for rapid sequence intubation in the emergency department.
abstract: A number of pharmacologic agents have been used for induction during rapid sequence intubation (RSI). Some of these agents may have adverse effects that can limit their use in certain clinical settings. This study was undertaken to determine the safety and utility of etomidate in patients with a range of underlying clinical conditions. Thirty-four patients underwent RSI in the emergency department (ED). Hemodynamic measurements and clinical assessments were recorded before and after intubation. The results suggest that etomidate is a safe and effective agent for use in a range of patients undergoing RSI in the ED.
authors.affiliation: Department of Emergency Medicine, Tufts University School of Medicine, Baystate Medical Center, Springfield, Massachusetts 01199, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Smith
authors.forename: J M
authors.initials: JM
authors.lastname: Bergen
authors.forename: H
authors.initials: H
authors.lastname: Smithline
authors.forename: R
authors.initials: R
authors.lastname: Kirschner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004638:Emergency Treatment; D005045:Etomidate / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007442:Intubation, Intratracheal / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D006993:Hypnotics and Sedatives; D005045:Etomidate