title: Operation Everest III (COMEX '97). Effects of prolonged and progressive hypoxia on humans during a simulated ascent to 8,848 M in a hypobaric chamber.
abstract: Exposure to high altitude induces physiological or pathological modifications that are not always clearly attributable to a specific environmental factor: hypoxia, cold, stress, inadequate food. The principal goal of hypobaric chamber studies is to determine the specific effect of hypoxia. Eight male volunteers ("altinauts"), aged 23 to 37 were selected. They were first preacclimatized in the Observatoire Vallot (4,350 m) before entering the chamber. The chamber was progressively decompressed down to 253 mmHg barometric pressure, with a recovery period of 3 days at 5,000 m in the middle of the decompression period. They spent a total of 31 days in the chamber. Eighteen protocols were organized by 14 European teams, exploring the limiting factors of physical and psychological performance, and the pathophysiology of acute mountain sickness (AMS). All subjects reached 8,000 m and 7 of them reached the simulated altitude of 8,848 m. Three altinauts complained of transient neurological symptoms which resolved rapidly with reoxygenation. Body weight decreased by 5.4 kg through a negative caloric balance. Only four days after the return to sea-level, subjects had recovered 3.4 kg, i.e. 63% of the total loss. At 8,848 m (n = 5), PaO2 was 30.6 +/- 1.4 mmHg, PCO2 11.9 +/- 1.4 mmHg, pH 7.58 +/- 0.02 (arterialized capillary blood). Hemoglobin concentration increased from 14.8 +/- 1.4 to 18.4 +/- 1.5 g/dl at 8,000 m and recovered within 4 days at sea-level. AMS score increased rapidly at 6,000 m and was maximal at 7,000 m, especially for sleep. AMS was related to alteration in color vision and elevation of body temperature. VO2MAX decreased by 59% at 7,000 m. The purpose of this paper is to give a general description of the study and the time course of the main clinical and physiological parameters. The altinauts reached the "summit" (for some of them three consecutive times) in better physiological conditions than it would have been possible in the mountains, probably because acclimatization and other environmental factors such as cold and nutrition were controlled.
authors.affiliation: Association pour la Recherche en Physiologie de l'Environnement, Laboratoire Réponses cellulaires et fonctionnelles à l'hypoxie (EA 2363), U.F.R. Médecine, Université Paris Nord, Bobigny, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Richalet
authors.forename: P
authors.initials: P
authors.lastname: Robach
authors.forename: S
authors.initials: S
authors.lastname: Jarrot
authors.forename: J C
authors.initials: JC
authors.lastname: Schneider
authors.forename: N P
authors.initials: NP
authors.lastname: Mason
authors.forename: E
authors.initials: E
authors.lastname: Cauchy
authors.forename: J P
authors.initials: JP
authors.lastname: Herry
authors.forename: A
authors.initials: A
authors.lastname: Bienvenu
authors.forename: B
authors.initials: B
authors.lastname: Gardette
authors.forename: C
authors.initials: C
authors.lastname: Gortan
mesh_terms: D000064:Acclimatization; D000328:Adult; D000531:Altitude; D001794:Blood Pressure; D001835:Body Weight; D018504:Ecological Systems, Closed; D005060:Europe; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic; D009051:Mountaineering / Q000502:physiology*; D009390:Nepal; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D018579:Patient Selection; D018609:Tibet
chemical_list: D006454:Hemoglobins; D010100:Oxygen