In vitro activity of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin against Ghanaian isolates of Mycobacterium ulcerans.
MICs of ciprofloxacin, sparfloxacin, ofloxacin, amikacin and rifampicin were determined for 14 primary clinical isolates and three reference isolates of Mycobacterium ulcerans by modifying a standard agar dilution method for testing Mycobacterium tuberculosis sensitivity. All these antimicrobials were active against every isolate of M. ulcerans. Sparfloxacin exhibited the highest activity and ofloxacin was the least effective. Rifampicin exhibited the broadest range of activity.
Thangaraj
H S
HS
Division of Infectious Diseases, St George's Hospital Medical School, London SW17 0RE, UK. hthangar@sghms.ac.uk
Adjei
O
O
Allen
B W
BW
Portaels
F
F
Evans
M R
MR
Banerjee
D K
DK
Wansbrough-Jones
M H
MH
D000583:Amikacin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D007917:Leprostatic Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009165:Mycobacterium Infections, Nontuberculous / Q000382:microbiology; D019911:Mycobacterium ulcerans / Q000187:drug effects*; D012293:Rifampin / Q000494:pharmacology*; D014454:Uganda
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007917:Leprostatic Agents; D000583:Amikacin; D012293:Rifampin