Sickle-cell disease not identified by newborn screening because of prior transfusion.
Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening >/=120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis.
Reed
W
W
Children's Hospital Oakland, Department of Hematology/Oncology, Oakland, CA 94609, USA.
Lane
P A
PA
Lorey
F
F
Bojanowski
J
J
Glass
M
M
Louie
R R
RR
Lubin
B H
BH
Vichinsky
E P
EP
D000751:Anemia, Neonatal / Q000628:therapy*; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D001787:Blood Group Incompatibility / Q000628:therapy*; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015997:Neonatal Screening