Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice.
The tissue concentration of lipid peroxides was determined in the brain, heart, liver, lung and kidney of accelerated senescence-prone (SAMP-8) and -resistant (SAMR-1) mice at 3, 6 and 9 months of age by a method involving chemical derivatization and high performance liquid chromatography. The level of lipid peroxides in the brain did not show an age-dependent change, but at each age the brain level of lipid peroxides was significantly higher in SAMP-8 than in SAMR-1. In contrast, the lipid peroxide levels in the peripheral organs showed increases with aging in both strains, and they were significantly higher in SAMP-8 than in SAMR-1 at both 3 and 6 months of age (except at 3 months of age in the kidney). These results suggest that increased oxidative stress in the brain and peripheral organs is a cause of the senescence-related degeneration and impairments seen in SAMP-8.
Matsugo
S
S
Department of Chemical and Biochemical Engineering and CREST, Faculty of Engineering, Toyama University, Japan.
Kitagawa
T
T
Minami
S
S
Esashi
Y
Y
Oomura
Y
Y
Tokumaru
S
S
Kojo
S
S
Matsushima
K
K
Sasaki
K
K
D000367:Age Factors; D019588:Aging, Premature / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry; D007668:Kidney / Q000737:chemistry; D015227:Lipid Peroxidation; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D051379:Mice; D008817:Mice, Mutant Strains; D009206:Myocardium / Q000737:chemistry; D009410:Nerve Degeneration; D009928:Organ Specificity; D018384:Oxidative Stress