title: Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe.
abstract: Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >/=32 microg/ml) was associated with the presence of vat(E) (satG) (14 isolates ¿50%) or vat(D) (satA) (6 isolates ¿21%). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 microg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium.
authors.affiliation: Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom.
authors.forename: M
authors.initials: M
authors.lastname: Soltani
authors.forename: D
authors.initials: D
authors.lastname: Beighton
authors.forename: J
authors.initials: J
authors.lastname: Philpott-Howard
authors.forename: N
authors.initials: N
authors.lastname: Woodford
mesh_terms: D000123:Acetyltransferases / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins; D004352:Drug Resistance, Microbial / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics*; D005060:Europe; D005798:Genes, Bacterial; D006801:Humans; D008460:Meat / Q000382:microbiology; D014769:Virginiamycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D014769:Virginiamycin; C062940:quinupristin-dalfopristin; D000123:Acetyltransferases; C084756:streptogramin A acetyltransferase, Enterococcus faecium