title: Development of oxygen sensitivity in infants of smoking and non-smoking mothers.
abstract: OBJECTIVE
  To assess the effect of prenatal cigarette smoke exposure on the postnatal resetting of oxygen sensitivity in term infants.
  
  
  METHODS
  15 healthy term infants of smoking mothers (median 10 cigarettes/day) and 16 controls were studied during quiet sleep 1, 3, and 10 days and 10 weeks postnatally. Strain-gauge respiratory trace was continuously recorded. Repeated 15-s challenges with 100% O2 and 15% O2 were presented in randomised order through a face mask. A median of six hyperoxic and six hypoxic challenges per recording were obtained. Breath-by-breath ventilation in a time-window from 20 s before onset of stimulus to 60 s after was extracted. For each infant at each age, the normalised coherently averaged response to hyperoxia and hypoxia was calculated. Mean ventilation at end of the 15-s stimulus was analysed with ANOVA, as were parameters describing a function fitted to each averaged response.
  
  
  RESULTS
  During air breathing, smoke-exposed infants had higher respiratory rates and lower tidal volumes than controls. Nicotine concentration in infant hair, measured by gas chromatography, was positively correlated with maternal level of smoking. A long-term development in oxygen sensitivity was demonstrated in both groups. However, neither the time-course nor the magnitude of O2 responses was affected by maternal smoking. Overall, hyperoxia reduced ventilation by 6.3% at day 1, 13.2% at day 3, 29.6% at day 10, and 40.0% at week 10. Transient hypoxia increased ventilation by 3.5%, 3.2%, 6.4%, and 8.8%, respectively, at the four ages studied.
authors.affiliation: Institute of Physiology, University of Oslo, Norway. signe.sovik@basalmed.uio.no
authors.forename: S
authors.initials: S
authors.lastname: Søvik
authors.forename: K
authors.initials: K
authors.lastname: Lossius
authors.forename: M
authors.initials: M
authors.lastname: Eriksen
authors.forename: J
authors.initials: J
authors.lastname: Grøgaard
authors.forename: L
authors.initials: L
authors.lastname: Walløe
mesh_terms: D000328:Adult; D002849:Chromatography, Gas; D005260:Female; D005865:Gestational Age; D006197:Hair / Q000737:chemistry; D006801:Humans; D018496:Hyperoxia; D000860:Hypoxia; D007231:Infant, Newborn; D009538:Nicotine / Q000032:analysis; D010100:Oxygen / Q000008:administration & dosage*; D011247:Pregnancy; D012119:Respiration; D012907:Smoking / Q000009:adverse effects*; D013990:Tidal Volume
chemical_list: D009538:Nicotine; D010100:Oxygen