Peripheral primitive neuroectodermal tumour of the cervix.
Peripheral primitive neuro-ectodermal tumours (PNET) of the cervix are very rare. Here, we report the clinical, pathological, immunohistochemical and genetic features of a case of a PNET located in the cervix. Hysterectomy revealed a cervical tumour. On microscopic examination, a vaguely lobular arrangement of uniformly appearing neoplastic cells, with round to oval nuclei, distinct nuclear membranes and a clear, moderately glycogen-rich cytoplasm was seen. Cells stained positive for LEU 7, S 100, monoclonal NSE and particularly for MIC2. Neurogenic differentiation was also seen by electron microscopic examination. The genetic hallmark of PNET, a 22q12 rearrangement was demonstrated by fluorescence in situ hybridisation experiments, supporting the diagnosis. Awareness of the existence of primary PNET of the cervix is important to avoid confusion with other tumours of the cervix.
Pauwels
P
P
Stichting PAMM, Catharina Ziekenhuis, Michelangelolaan 2, NL-5623 EJ Eindhoven, The Netherlands. lvpa@worldonline.nl
Ambros
P
P
Hattinger
C
C
Lammens
M
M
Dal Cin
P
P
Ribot
J
J
Struyk
A
A
van den Berghe
H
H
D014408:Biomarkers, Tumor / Q000032:analysis; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor