title: Effects of primary resuscitation from shock on distribution of myocardial blood flow.
abstract: Hemorrhagic shock alters heterogeneity of regional myocardial perfusion (RMP) in the presence of critical coronary stenosis in pigs. Conventional resuscitation has failed to reverse these effects. We hypothesized that improvement of the resuscitation regime would lead to restoration of RMP heterogeneity. Diaspirin-cross-linked hemoglobin (10 g/dl; DCLHb) and human serum albumin (8.0 g/dl; HSA) were used. After baseline, a branch of the left coronary artery was stenosed; thereafter, hemorrhagic shock was induced. Resuscitation was performed with either DCLHb or HSA. At baseline, the fractcal dimension (D) of subendocardial myocardium was 1.31 +/- 0.083 (HSA) and 1.35 +/- 0.106 (DCLHb) (mean +/- SD). Coronary stenosis increased subendocardial D slightly but consistently only in the DCLHb group (1.39 +/- 0.104; P < 0.05). Shock reduced subendocardial D: 1.21 +/- 0.093 (HSA; P = 0.10), 1.25 +/- 0.092 (DCLHb; P < 0.05). Administration of DCLHb increased subendocardial D in 7 of 10 animals (1.31 +/- 0.097; P = 0.066). HSA was ineffective in this respect. DCLHb infusion restored arterial pressure and increased cardiac index (CI) to 80% of baseline values. Administration of HSA left animals hypotensive (69 mmHg) and increased CI to 122% of the average baseline value. Shock-induced disturbances of the distribution of RMP were improved by administration of DCLHb but not by HSA.
authors.affiliation: Institute for Surgical Research, University of Munich, 81366 Munich, Germany. kleen@icf.med.uni-muenchen.de
authors.forename: M
authors.initials: M
authors.lastname: Kleen
authors.forename: O
authors.initials: O
authors.lastname: Habler
authors.forename: F
authors.initials: F
authors.lastname: Meisner
authors.forename: G
authors.initials: G
authors.lastname: Kemming
authors.forename: A
authors.initials: A
authors.lastname: Pape
authors.forename: K
authors.initials: K
authors.lastname: Messmer
mesh_terms: D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006454:Hemoglobins / Q000494:pharmacology; D006801:Humans; D007022:Hypotension / Q000209:etiology; D008875:Middle Aged; D012151:Resuscitation; D012709:Serum Albumin / Q000009:adverse effects / Q000494:pharmacology; D012771:Shock, Hemorrhagic / Q000503:physiopathology* / Q000628:therapy; D013552:Swine
chemical_list: D006454:Hemoglobins; D012709:Serum Albumin; C083478:diaspirin-cross-linked hemoglobin; D001241:Aspirin