Synthesis and conformational analysis of 3-substituted derivatives of 1H, 3H-pyrido[2,3-d]pyrimidin-4-one of expected depressive activity on central nervous system. Part II.
Two series of new 1-aryl piperazinylacetyl derivatives of 1H, 3H-pyrido[2,3-d]pyrimidyn-4-one were synthesized. The compounds were prepared by chloroacetylation; when made to react with respective arylpiperazine, then yielded VIa-o. The structures of compounds VIa-o were analyzed by 1H and 13C NMR spectroscopy. For selected compounds, acute toxicity and anticonvulsant activity were determined.
Herold
F
F
Department of Drug Technology, Faculty of Pharmacy, Medical University of Warsaw, Poland.
Kleps
J
J
Chodkowski
A
A
Gutkowska
B
B
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000927:Anticonvulsants; D011743:Pyrimidines