title: A three-dimensional virtual environment for modeling mechanical cardiopulmonary interactions.
abstract: We have developed a real-time computer system for modeling mechanical physiological behavior in an interactive, 3-D virtual environment. Such an environment can be used to facilitate exploration of cardiopulmonary physiology, particularly in situations that are difficult to reproduce clinically. We integrate 3-D deformable body dynamics with new, formal models of (scalar) cardiorespiratory physiology, associating the scalar physiological variables and parameters with the corresponding 3-D anatomy. Our framework enables us to drive a high-dimensional system (the 3-D anatomical models) from one with fewer parameters (the scalar physiological models) because of the nature of the domain and our intended application. Our approach is amenable to modeling patient-specific circumstances in two ways. First, using CT scan data, we apply semi-automatic methods for extracting and reconstructing the anatomy to use in our simulations. Second, our scalar physiological models are defined in terms of clinically measurable, patient-specific parameters. This paper describes our approach, problems we have encountered and a sample of results showing normal breathing and acute effects of pneumothoraces.
authors.affiliation: Center for Human Modeling and Simulation, Philadelphia VA Medical Center & University of Pennsylvania, 19104-6389, USA. kaye@linc.cis.upenn.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Kaye
authors.forename: F P
authors.initials: FP
authors.lastname: Primiano
authors.forename: D N
authors.initials: DN
authors.lastname: Metaxas
mesh_terms: D003198:Computer Simulation; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D015656:Respiratory Mechanics; D013909:Thorax / Q000033:anatomy & histology*; D014584:User-Computer Interface