title: Solid-Phase Synthesis of a Monofunctional trans-a(2)Pt(II) Complex Tethered to a Single-Stranded Oligonucleotide.
abstract: Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) building unit, ammonolysis, and transformation of the resulting complex (R=1-N-cyclohexylmethylthyminate) into the chloro derivative (R=Cl). a=NH(2)CH(3), T=thymine.
authors.affiliation: Leiden Institute of Chemistry Gorlaeus Laboratories, Leiden University 2300 RA Leiden (The Netherlands).
authors.initials: KS
authors.lastname: Schmidt
authors.initials: DV
authors.lastname: Filippov
authors.initials: NJ
authors.lastname: Meeuwenoord
authors.lastname: van Der Marel GA
authors.lastname: van Boom JH
authors.initials: B
authors.lastname: Lippert
authors.initials: J
authors.lastname: Reedijk