title: Expression of Chx10 and Chx10-1 in the developing chicken retina.
abstract: We have isolated full-length cDNAs of chick Chx10 and Chx10-1, two members of the paired type homeobox/CVC gene family. A comparison of sequences suggests that Chx10 is closely related to Alx/Vsx-2 and Vsx-2 of zebrafish and goldfish, respectively; while Chx10-1 is closely related to Vsx-1 of zebrafish and goldfish. Chx10 and Chx10-1 are expressed in the early retinal neuroepithelium, but not in the pigment epithelium and lens. The expression of Chx10 is present in most retinal neuroblasts, while Chx10-1 exhibits a novel pattern along the nasotemporal border. In the differentiating retina, both Chx10 and Chx10-1 are restricted to bipolar cells and are maintained at a low level in bipolar cells of the mature retina.
authors.affiliation: Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Chen
authors.forename: C L
authors.initials: CL
authors.lastname: Cepko
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D002642:Chick Embryo; D005136:Eye Proteins / Q000235:genetics; D015870:Gene Expression; D018398:Homeodomain Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D012160:Retina / Q000196:embryology*; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D030161:Avian Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D014157:Transcription Factors