title: Relating axonal injury to functional recovery in MS.
abstract: A patient was followed after the new onset of hemiparesis from relapse of MS with serial MR spectroscopy and functional MRI. The association of clinical improvement with recovery of N-acetylaspartate, a marker of neuronal integrity, and progressive reduction of abnormally large functional MRI cortical activation with movement demonstrates that dynamic reorganization of the motor cortex accompanies remission of MS.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal-Neurological Institute, McGill University, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Narayanan
authors.forename: P M
authors.initials: PM
authors.lastname: Matthews
authors.forename: R D
authors.initials: RD
authors.lastname: Hoge
authors.forename: G B
authors.initials: GB
authors.lastname: Pike
authors.forename: P
authors.initials: P
authors.lastname: Duquette
authors.forename: J
authors.initials: J
authors.lastname: Antel
authors.forename: D L
authors.initials: DL
authors.lastname: Arnold
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001369:Axons / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D009473:Neuronal Plasticity; D020127:Recovery of Function; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate