Synthesis of new derivatives of 1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]pyrimidin-5-one active in CNS. Part 2. Synthesis and results of preliminary pharmacological screening of 7-(substituted)amino-1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]pyrimid in-5- ones.
Synthesis of new 7-(substituted)amino-1-alkyl-2-aryl-1H-2,3-dihydroimidazo[1,2-a]py rimidin-5- ones bearing the 4-arylpiperazin-1-yl moiety connected by ethyl or acetoyl two-carbonyl chain extension was described. The arylpiperazinyl moiety was introduced by alkylation or acylation with corresponding halogeno-derivatives. Preliminary pharmacological screening showed the 7-(substituted)-amino derivatives of the system investigated to exhibit the CNS activity lesser than that of the 7-amino derivatives and to have no effect on the serotonin neurotransmission pathway.
Matosiuk
D
D
Department of Medicines Technology, Faculty of Pharmacy, Medical University, Lublin, Poland. darek@eskulap.am.lublin.pl
Tkaczyński
T
T
Stefańczyk
J
J
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002491:Central Nervous System Agents / Q000138:chemical synthesis / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
D002491:Central Nervous System Agents; D010879:Piperazines; D011743:Pyrimidines