Enhancement of swimming endurance in mice by highly branched cyclic dextrin.
We investigated the ergogenic effect in mice of administering highly branched cyclic dextrin (HBCD), a new type of glucose polymer, on the swimming endurance in an adjustable-current swimming pool. Male Std ddY mice were administered a HBCD, a glucose solution or water via a stomach sonde 10 min before, 10 min after or 30 min after beginning swimming exercise, and were then obliged to swim in the pool. The total swimming period until exhaustion, an index of the swimming endurance, was measured. An ergogenic effect of HBCD was observed at a dose of 500 mg/kg of body weight, whereas it had no effect at a dose of 166 mg/kg of body wt (p < 0.05). The mice administered with the HBCD solution 10 min after starting the exercise were able to swim significantly longer (p < 0.05) than the mice who had ingested water or the glucose solution. The rise in mean blood glucose level in the mice administered with HBCD, which was measured 20 min after starting swimming, was significantly lower (p < 0.05) than that in the mice administered with glucose, although it was significantly higher (p < 0.05) than that in the mice administered with water. The mean blood insulin rise in the mice given HBCD was significantly lower (p < 0.05) than that in the mice given glucose. The mice administered with HBCD 30 min after starting the exercise swam significantly longer (p < 0.05) than the mice who had ingested water, although the enhancement of swimming time was similar to that of the glucose-ingesting mice. The gastric emptying rate of the HBCD solution was significantly faster (p < 0.05) than that of the glucose solution. However, this glucose polymer must have spent more time being absorbed because it has to be hydrolyzed before absorption, reflecting a lower and possibly longer-lasting blood glucose level. We conclude that the prolongation of swimming endurance in mice administered with HBCD depended on its rapid and longer-lasting ability for supplying glucose with a lower postprandial blood insulin response, leading to a delayed onset of fatigue.
Takii
H
H
Biochemical Research Laboratory, Ezaki Glico Co. Ltd., Osaka, Japan. takii-hiroshi@glico.co.jp
Ishihara
K
K
Kometani
T
T
Okada
S
S
Fushiki
T
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003912:Dextrins / Q000494:pharmacology*; D019587:Dietary Supplements; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D010805:Physical Conditioning, Animal; D010807:Physical Endurance / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013550:Swimming
D001786:Blood Glucose; D003912:Dextrins; D007328:Insulin