Phosphatases and kinases delivered to the host cell by bacterial pathogens.
The gram-negative type III secretion pathway translocates bacterial proteins directly into eukaryotic host cells, thus allowing a pathogen to interfere directly with host signalling pathways. Protein and inositol phosphatases and protein kinases have been identified as delivered effectors in three bacterial pathogens, Salmonella, Shigella and Yersinia, and it is expected that several more such type III effectors will be found.
DeVinney
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Biotechnology Laboratory, University of British Columbia, Vancouver British Columbia, Canada V6T 1Z3.
Steele-Mortimer
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Finlay
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D001425:Bacterial Outer Membrane Proteins / Q000502:physiology; D001426:Bacterial Proteins / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism* / Q000502:physiology; D012475:Salmonella / Q000378:metabolism; D012760:Shigella / Q000378:metabolism; D015398:Signal Transduction; D015007:Yersinia / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D011494:Protein Kinases; D010744:Phosphoric Monoester Hydrolases; C021822:myo-inositol-1 (or 4)-monophosphatase; D017027:Protein Tyrosine Phosphatases; C067571:yopH protein, Yersinia