Using AIDS mortality data to reconstruct HIV/AIDS epidemics.
The back-calculation methods used to reconstruct HIV epidemics and to predict future AIDS cases use data on the number of AIDS reported cases and information about the time from HIV infection to AIDS diagnosis. In this paper we modify a back-calculation method, presented in Verdecchia and Mariotto, to estimate HIV incidence from AIDS mortality data rather than the AIDS registered cases. In this application the AIDS incubation time is replaced by the time from HIV infection to AIDS death. Since AIDS is an irreversible condition leading to death within a few years, mortality data is expected to be approximately as informative as AIDS data. The main application of this method would be in countries where an AIDS registry is not available or where the registration of AIDS cases is not consistent, for example, due to changes in the definition of AIDS. Application to the Italian AIDS mortality data shows that the number of AIDS cases reconstructed from this method is very close to the registered number of cases. Also, the two estimates of HIV incidence and prevalence obtained from back-calculation on both AIDS mortality data and the number of AIDS reported cases were very similar, although there was more variability in the estimates obtained from mortality data.
Mariotto
A B
AB
Istituto Superiore di Sanitá, Viale Regina Elena 299, Roma 00161, Italy.
Verdecchia
A
A
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology* / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015995:Prevalence; D012737:Sex Factors; D016019:Survival Analysis; D013997:Time Factors