Association of KM genotype with bullous pemphigoid.
Association of kappa light chain immunoglobulin allotypes with bullous pemphigoid was examined in 101 Caucasian patients. Km alleles were determined by polymerase chain reaction amplification followed by restriction enzyme digestion. The frequency of Km(3)/Km(1,2)kappa light-chain genotype was found to be significantly associated with the disease, while that of the Km(3)homozygous genotype was significantly higher in patients with both anti-BPAG1 and anti-BPAG2 autoantibodies.
Raux
G
G
INSERM U519, Institut Fédératif de Recherche Multidisciplinaire sur les Peptides (IFR 23), Hôpital Charles Nicolle et Faculté Mixte de Médecine et de Pharmacie, Rouen, France.
Gilbert
D
D
Joly
P
P
Daveau
M
M
Martel
P
P
Christ
M
M
Tron
F
F
D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity / Q000235:genetics; D001483:Base Sequence; D002352:Carrier Proteins; D016022:Case-Control Studies; D003094:Collagen / Q000276:immunology; D003598:Cytoskeletal Proteins; D017931:DNA Primers / Q000235:genetics; D000071821:Dystonin; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D010391:Pemphigoid, Bullous / Q000235:genetics* / Q000276:immunology*; D000097805:Collagen Type XVII
D001324:Autoantigens; D002352:Carrier Proteins; D003094:Collagen; D003598:Cytoskeletal Proteins; D017931:DNA Primers; D000071821:Dystonin; D005819:Genetic Markers; D007126:Immunoglobulin Allotypes; D009419:Nerve Tissue Proteins; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C486268:DST protein, human