title: Disinfectants/antiseptics in the management of guinea worm ulcers in the rural areas.
abstract: The effectiveness of trichlorophenol (TCP), chlorhexidine gluconate plus cetrimide (Savlon) and Izal in inhibiting the growth of bacterial isolates from guinea worm ulcers was investigated. Using an adaptation of the method of Russell and Furr (Russell, A.D., Furr, J.R., 1977. The antibacterial activity of a new chloroxylenol preparation containing ethylenediamine tetraacetic acid. J. Appl. Bacteriol. 43, 253-260) the minimum inhibitory concentration (MIC) values of the three anti-microbial agents for each of the isolated bacteria was determined. Water drawn from the rural guinea worm endemic sites was autoclaved and used for the various dilutions of the anti-microbial agents. At the manufactures' recommended use-dilutions in cases of wounds/cuts/sores, Savlon showed greater effectiveness than Izal and TCP in this order. Probable organic and inorganic inhibitors in water that is usually employed in diluting anti-microbial agents in the rural areas for the dressing of guinea worm ulcers very likely had greatest effect(s) on TCP and least effect(s) on Savlon.
authors.affiliation: Department of Medical Microbiology and Parasitology, Obafemi Awolowo University, Ile-Ife, Nigeria. togunniy@oauife.edu.ng
authors.forename: T A
authors.initials: TA
authors.lastname: Ogunniyi
authors.forename: P O
authors.initials: PO
authors.lastname: Oni
authors.forename: A
authors.initials: A
authors.lastname: Juba
authors.forename: S O
authors.initials: SO
authors.lastname: Asaolu
authors.forename: D O
authors.initials: DO
authors.lastname: Kolawole
mesh_terms: D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D002593:Cetrimonium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000494:pharmacology / Q000627:therapeutic use*; D004202:Disinfectants / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004320:Dracunculiasis / Q000188:drug therapy* / Q000382:microbiology; D004321:Dracunculus Nematode; D004338:Drug Combinations; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D012423:Rural Health; D014456:Ulcer / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000891:Anti-Infective Agents, Local; D002593:Cetrimonium Compounds; D004202:Disinfectants; D004338:Drug Combinations; C012027:savlon; D002710:Chlorhexidine