[Myocardial cytoprotection with trimetazidine in patients with ischemic heart disease during surgical stress].
Fluctuations of the thiol disulfide system were shown to be interrelated with changes in the ECG indices. Trimetazidine since it has antioxidant properties was found to be effective in patients with low thiol disulfide ratios. A single dose of 0.8 mg/kg of the body mass was shown to inhibit the appearance of stress-dependent ischemic symptoms during surgical procedures.
Afanas'eva
I V
IV
Goncharova
L L
LL
Miroshnichenko
A G
AG
Petrash
V V
VV
Pokrovskaia
L A
LA
D000368:Aged; D019610:Cytoprotection; D004220:Disulfides / Q000097:blood; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000188:drug therapy; D013312:Stress, Physiological / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D013438:Sulfhydryl Compounds / Q000097:blood; D014292:Trimetazidine / Q000494:pharmacology* / Q000627:therapeutic use; D013521:Urologic Surgical Procedures, Male / Q000009:adverse effects*; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D004220:Disulfides; D013438:Sulfhydryl Compounds; D014665:Vasodilator Agents; D014292:Trimetazidine