Fatal disseminated infection by Scedosporium prolificans during induction therapy for acute leukemia: a case report and literature review.
We report a case of fatal disseminated fungal infection by Scedosporium prolificans which occurred in a patient with acute leukemia during induction chemotherapy. Rapid clinical deterioration despite high-dose empirical amphotericin B highlights both the pathogenicity of this fungus in immunocompromised hosts and its resistance to standard antifungal therapy.
Westerman
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Peter MacCallum Cancer Institute, East Melbourne, Vic., Australia. davidwesterman@petermac.unimelb.edu.au
Speed
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Prince
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D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D017809:Fatal Outcome; D005260:Female; D016469:Fungemia / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008271:Mycetoma / Q000188:drug therapy / Q000209:etiology*; D011541:Pseudallescheria / Q000302:isolation & purification* / Q000472:pathogenicity
D003561:Cytarabine; D000666:Amphotericin B; D003630:Daunorubicin