Molecular motors and their role in pigmentation.
Skin pigmentation is orchestrated through a series of complementary processes. After migration of melanoblasts out of the neural crest to epidermis and hair follicle, these cells mature into melanocytes. Differentiated melanocytes produce melanin in specialized organelles, the melanosomes. Moreover, the cytoplasm of melanocytes branches into extensions, the dendrites. Via the tips of these dendrites they donate their mature melanosomes to the keratinocytes resulting in skin pigmentation. Thus, one essential part of the process of pigmentation is the translocation of melanosomes from their site of origin in the perinuclear cytoplasm towards the dendrite tips. Motor proteins are molecules which use the energy derived from ATP hydrolysis to move along cytoskeletal elements, either actin filaments or microtubules, to transport their cargo, which can be organelles, vesicles or chromosomes. This review describes the different classes of microtubule-based and actin-based motor proteins with their characteristics and functional importance in cell biology and organelle transport. Some of them will be highlighted and several recent studies in mammalian pigment cells indicating their role in pigment granule transport will be discussed. As a result of these data and previous suggestions, a model will be proposed for the possible cooperation of both systems in melanosome movement.
Lambert
J
J
Department of Dermatology, University Hospital, Gent, Belgium.
Vancoillie
G
G
Naeyaert
J M
JM
D008841:Actin Cytoskeleton / Q000502:physiology; D000199:Actins / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D001693:Biological Transport, Active; D002454:Cell Differentiation; D004398:Dyneins / Q000502:physiology; D000078404:Epidermal Cells; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D016547:Kinesins / Q000502:physiology; D008543:Melanins / Q000378:metabolism*; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism; D020460:Melanosomes / Q000378:metabolism / Q000648:ultrastructure; D008870:Microtubules / Q000502:physiology; D020409:Molecular Motor Proteins / Q000502:physiology*; D012880:Skin Pigmentation / Q000502:physiology*
D000199:Actins; D008543:Melanins; D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D004398:Dyneins; D016547:Kinesins