title: GHKL, an emergent ATPase/kinase superfamily.
abstract: An interesting recent development is the recognition of a novel ATP-binding superfamily that includes diverse protein families such as DNA topoisomerase II, molecular chaperones Hsp90, DNA-mismatch-repair enzymes MutL and histidine kinases. The most singular unifying feature of this superfamily is the unconventional Bergerat ATP-binding fold. The far-reaching significance of this commonality is still in the process of being explored.
authors.affiliation: Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
authors.forename: R
authors.initials: R
authors.lastname: Dutta
authors.forename: M
authors.initials: M
authors.lastname: Inouye
mesh_terms: D000251:Adenosine Triphosphatases; D000255:Adenosine Triphosphate / Q000378:metabolism; D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D020134:Catalytic Domain; D004250:DNA Topoisomerases, Type II / Q000737:chemistry / Q000378:metabolism*; D029968:Escherichia coli Proteins; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D000071677:Histidine Kinase; D006868:Hydrolysis; D008969:Molecular Sequence Data; D000070956:MutL Proteins; D017510:Protein Folding; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D018841:HSP90 Heat-Shock Proteins; C074770:MutL protein, E coli; D000255:Adenosine Triphosphate; D011494:Protein Kinases; D000071677:Histidine Kinase; D000251:Adenosine Triphosphatases; D000070956:MutL Proteins; D004250:DNA Topoisomerases, Type II