title: Endometrial release of soluble intercellular adhesion molecule 1 and endometriosis: relationship to the extent of the disease.
abstract: OBJECTIVE
  To relate endometrial release of the soluble form of intercellular adhesion molecule 1 with extent of endometriosis.
  
  
  METHODS
  Samples of endometrium were collected from 23 women with endometriosis. Soluble intercellular adhesion molecule 1 was quantified in conditioned medium from 48-hour endometrial stromal cell cultures with use of a specific enzyme-linked immunosorbent assay. Levels were correlated with revised American Society for Reproductive Medicine classification score for adhesions, implants, and cysts and total score; number of endometriotic implants; cyst diameter; and presence or absence of pelvic pain symptoms and previous surgical procedures for endometriosis.
  
  
  RESULTS
  Endometrial release of soluble intercellular adhesion molecule 1 directly correlated with number of implants (r = .64, P < .005) and score for implants (r = .61, P < .005). There was no significant correlation between levels of the soluble molecule and score for adhesions or total score. Soluble intercellular adhesion molecule 1 shed by endometrium did not correlate with the score for ovarian cysts, although an inverse relationship was found with ovarian cyst diameter (r = -0.52, P < .05). No differences were detected between women who had pelvic pain and those who did not and between those who had previous surgery for endometriosis and those who had not.
  
  
  CONCLUSIONS
  The association between endometrial release of soluble intercellular adhesion molecule 1 and the number and score of endometriotic implants suggests that the molecule might be of value in evaluating spread potential of refluxed endometrium.
authors.affiliation: II Department of Obstetrics and Gynecology, University of Milan and Istituto Auxologico Italiano.
authors.forename: P
authors.initials: P
authors.lastname: Viganò
authors.forename: E
authors.initials: E
authors.lastname: Somigliana
authors.forename: B
authors.initials: B
authors.lastname: Gaffuri
authors.forename: R
authors.initials: R
authors.lastname: Santorsola
authors.forename: M
authors.initials: M
authors.lastname: Busacca
authors.forename: M
authors.initials: M
authors.lastname: Vignali
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D004715:Endometriosis / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D004717:Endometrium / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D010048:Ovarian Cysts / Q000150:complications / Q000378:metabolism; D017699:Pelvic Pain / Q000378:metabolism
chemical_list: D018799:Intercellular Adhesion Molecule-1