Effects of glucagon, insulin, amylin and CGRP on feeding.
The roles of the pancreatic peptides glucagon, insulin, and amylin in the inhibitory control of feeding are reviewed. Calcitonin gene-related peptide (CGRP) is also included because it is structurally and functionally related to amylin and because known amylin and CRRP receptors are activated by both peptides. Glucagon-like peptide 1, in contrast, is structurally distinct from pancreatic glucagon and does not cross-react with glucagon receptors, so it is not considered. Several detailed reviews of the feeding effects of these peptides have appeared recently; where appropriate, these are cited rather than the primary literature.
Geary
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E. W. Bourne Behavioral Research Laboratory, New York Presybterian Hospital and Weill Medical College of Cornell University, White Plains, NY, 10605, USA.
D000682:Amyloid / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D004435:Eating / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005934:Glucagon / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology* / Q000502:physiology; D058228:Islet Amyloid Polypeptide
D000682:Amyloid; D005765:Gastrointestinal Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D005934:Glucagon; D015740:Calcitonin Gene-Related Peptide