Improving effect of dietary taurine on marked hypercholesterolemia induced by a high-cholesterol diet in streptozotocin-induced diabetic rats.
The effect of dietary taurine on hypercholesterolemia induced by a high-cholesterol diet in streptozotocin (STZ)-induced diabetic rats was investigated. The concentrations of serum and liver cholesterol were markedly elevated in STZ-diabetic rats fed on the cholesterol-containing diet, and dietary taurine significantly reduced this elevated level of cholesterol in the serum and liver. The gene expression of cholesterol 7 alpha-hydroxylase (CYP7A1), which is the rate-limiting enzyme for cholesterol degradation, was induced by the supplementation of taurine to the high-cholesterol diet. It is suggested that one of the reasons for this hypocholesterolemic action by taurine might have been the enhancement of cholesterol degradation.
Mochizuki
H
H
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Takido
J
J
Oda
H
H
Yokogoshi
H
H
D000818:Animals; D002784:Cholesterol / Q000097:blood / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics; D002791:Cholesterol, Dietary; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism; D019587:Dietary Supplements; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000008:administration & dosage / Q000627:therapeutic use*; D014158:Transcription, Genetic; D015430:Weight Gain / Q000187:drug effects
D002791:Cholesterol, Dietary; D013654:Taurine; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase