Molecular motors: the driving force behind mammalian left-right development.
The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development.
Supp
D M
DM
Research Dept, Shriners Hospital for Children, Cincinnati, OH 45229, USA.
Potter
S S
SS
Brueckner
M
M
D000818:Animals; D019521:Body Patterning / Q000187:drug effects* / Q000502:physiology; D004398:Dyneins / Q000494:pharmacology / Q000502:physiology; D005314:Embryonic and Fetal Development; D006801:Humans; D016547:Kinesins / Q000494:pharmacology / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000494:pharmacology / Q000502:physiology*
D008869:Microtubule-Associated Proteins; D004398:Dyneins; D016547:Kinesins