[Williams syndrome].
Williams syndrome (WS) is a rare (2-5/100,000) genetic human disorder characterised by a typical facies and mental retardation with a deficit in the visuospatial cognitive function and a relative preservation of linguistic abilities in general, and spoken language in particular. This syndrome also includes morphological anomalies, metabolic functional impairments, and likely deficits in the pattern of brain ontogenesis. The genetic basis of WS, recently identified, are presented. A cognitive profile of the WS individuals is defined and compared to Down syndrome (DS) and autism cognitive profiles. Neuroanatomical features of WS, including a reduction in brain volume, preservation of cerebellum and frontal lobes, and a reduction of posterior cortical systems, are described. The possible role of NGF (nerve growth factor)--a neurotrophin involved in the development of brain cholinergic systems and the associated behavioural functions--in the aetiology of the typical mental retardation of WS patients, is critically discussed. Future research avenues, including the identification of potential neurobiological markers in order to precociously diagnose this syndrome, are reviewed.
Alleva
E
E
Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Roma.
Cirulli
F
F
Calamandrei
G
G
Rondinini
C
C
Capirci
O
O
Aloe
L
L
Volterra
V
V
D015415:Biomarkers; D003072:Cognition Disorders / Q000209:etiology; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism; D018980:Williams Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D015415:Biomarkers; D009414:Nerve Growth Factors; D013002:Somatomedins; D013006:Growth Hormone