Candida albicans-derived beta-1,2-linked mannooligosaccharides induce desensitization of macrophages.
Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1, 2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.
Jouault
T
T
Laboratoire de Mycologie Fondamentale et Appliquée, INSERM E9915, Université de Lille II, Faculté de Médecine H. Warembourg, Lille, France. tjou@worldnet.fr
Fradin
C
C
Trinel
P A
PA
Poulain
D
D
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002176:Candida albicans / Q000502:physiology*; D002460:Cell Line; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology; D008362:Mannosides / Q000494:pharmacology*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis; D009844:Oligosaccharides / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D008070:Lipopolysaccharides; D008362:Mannosides; D009844:Oligosaccharides; D014409:Tumor Necrosis Factor-alpha; D016718:Arachidonic Acid; D009569:Nitric Oxide; D011505:Protein-Tyrosine Kinases