Mouse BTEB3, a new member of the basic transcription element binding protein (BTEB) family, activates expression from GC-rich minimal promoter regions.
Members of the three-zinc-finger family of transcription factors play an important role in determining basal transcription. We have cloned mouse BTEB3 (mBTEB3), a new member of the basic transcription element binding protein (BTEB) family, which is expressed in a wide variety of tissues. mBTEB3 activates transcription of the simian virus 40 early promoter (4-fold) and of the tissue-specific SM22alpha promoter (100-fold), suggesting that, like BTEB1 and Sp1, mBTEB3 is a basal transcription factor.
Martin
K M
KM
Section of Cardiovascular Biology, Department of Biochemistry, Cambridge University, Tennis Court Road, Cambridge CB2 1QW, U.K.
Cooper
W N
WN
Metcalfe
J C
JC
Kemp
P R
PR
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018797:Cell Cycle Proteins; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D020862:GC Rich Sequence; D018507:Gene Expression Regulation, Developmental; D051741:Kruppel-Like Transcription Factors; D051379:Mice; D008840:Microfilament Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators / Q000235:genetics* / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C489676:KLF9 protein, human; C486422:Klf13 protein, mouse; C489675:Klf9 protein, mouse; D051741:Kruppel-Like Transcription Factors; D008840:Microfilament Proteins; D009124:Muscle Proteins; D012097:Repressor Proteins; C058992:Tagln protein, mouse; D015534:Trans-Activators; D014157:Transcription Factors; C051615:transgelin