[Adhesion molecule ICAM-1 in patients with chronic polyarthritis--effects of inpatient rehabilitation].
In rheumatoid arthritis (RA) the adhesion molecule ICAM-1 mediates the adhesion of leucocytes following subsequent transendothelial migration including interactions and adhesion of several cell types such as fibroblasts, T-lymphocytes and synoviocytes. Significantly increased ICAM-1 levels were measured in the acute phase of RA. The correlation of ICAM-1 levels with the pteridine neopterin (p < or = 0.01) may reflect the role of this adhesion molecule in modulation of immune responses. Despite the significantly higher levels of acute phase reactions parallel to the elevated ICAM-1 levels, no correlations were found between ICAM-1 and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and serum-Amyloid A (SAA). During an in-patient multidisciplinary rehabilitation programme the levels of ICAM-1 in serum and the majority of all investigated laboratory and clinical parameters such as ESR, CRP, SAA, fibrinogen, pain, swollen and painful joint count, morning stiffness and health assessment questionnaire improved.
Kullich
W
W
Ludwig Boltzmann Institut für Rehabilitation interner Erkrankungen, Saalfelden. lbirehab@salzburg.co.at
Neff
H
H
Pöllmann
G
G
Machreich
K
K
Schwann
H
H
D000209:Acute-Phase Proteins / Q000378:metabolism; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010348:Patient Care Team; D012047:Rehabilitation Centers; D016896:Treatment Outcome
D000209:Acute-Phase Proteins; D018799:Intercellular Adhesion Molecule-1