title: Isolation and structures of schleicherastatins 1-7 and schleicheols 1 and 2 from the teak forest medicinal tree Schleichera oleosa.
abstract: Bioassay (P-388 lymphocytic leukemia cell line)-guided separation of an extract prepared from the bark and stem of the Sri Lankan tree Schleichera oleosa led to the isolation of seven cancer cell growth inhibitory hydroxylated sterols designated schleicherastatins 1-7 (1-7) and two related sterols, schleicheols 1 and 2 (8, 9). The structure of schleicherastatin 1 (1) was completely elucidated by X-ray crystal structure determination. Based upon that defined structure, the remaining new sterol structures were deduced by highfield (300 and 500 MHz) NMR and MS interpretations. In this new series of sterols, hydroxylation at C-22 appears to be important for promoting cancer cell growth inhibition.
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: A
authors.initials: A
authors.lastname: Numata
authors.forename: G M
authors.initials: GM
authors.lastname: Cragg
authors.forename: D L
authors.initials: DL
authors.lastname: Herald
authors.forename: T
authors.initials: T
authors.lastname: Takada
authors.forename: C
authors.initials: C
authors.lastname: Iwamoto
authors.forename: R
authors.initials: R
authors.lastname: Riesen
authors.forename: J M
authors.initials: JM
authors.lastname: Schmidt
authors.forename: D L
authors.initials: DL
authors.lastname: Doubek
authors.forename: A
authors.initials: A
authors.lastname: Goswami
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification*; D014197:Trees / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013261:Sterols