Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients.
To determine the frequency of in vivo activated T(H)1 lymphocytes, T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.
Strunk
T
T
Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine, Germany.
Bubel
S
S
Mascher
B
B
Schlenke
P
P
Kirchner
H
H
Wandinger
K P
KP
D000328:Adult; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D015759:Ionomycin / Q000494:pharmacology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology; D019713:Receptors, CCR5 / Q000378:metabolism*; D012016:Reference Values; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D019713:Receptors, CCR5; D014409:Tumor Necrosis Factor-alpha; D015759:Ionomycin; D007371:Interferon-gamma; D018819:Dipeptidyl Peptidase 4; D013755:Tetradecanoylphorbol Acetate