Flumazenil reversal of carisoprodol (Soma) intoxication.
A 52-year-old woman presented with central nervous system depression and a Glasgow Coma Score of 9 secondary to ingestion of carisoprodol, a centrally acting muscle relaxant analgesic. After administration of i.v. flumazenil, the patient's neurologic status normalized and she required no further therapy. Carisoprodol and its active sedative-hypnotic metabolite, meprobamate, are gamma aminobutyric acid receptor indirect agonists with central nervous system chloride ion channel conduction effects similar to the benzodiazepines, thus making flumazenil a potentially useful antidote in toxic presentations.
Roberge
R J
RJ
Department of Emergency Medicine, Western Pennsylvania Hospital, Pittsburgh 15224, USA.
Lin
E
E
Krenzelok
E P
EP
D000931:Antidotes / Q000627:therapeutic use*; D002328:Carisoprodol / Q000506:poisoning*; D002490:Central Nervous System / Q000187:drug effects*; D004630:Emergencies; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use*; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000506:poisoning*
D000931:Antidotes; D018757:GABA Modulators; D009125:Muscle Relaxants, Central; D002328:Carisoprodol; D005442:Flumazenil