title: In vitro interaction of terbinafine with itraconazole against clinical isolates of Scedosporium prolificans.
abstract: In order to develop new approaches for the chemotherapy of invasive infections caused by Scedosporium prolificans, the in vitro interaction between itraconazole and terbinafine against 20 clinical isolates was studied using a checkerboard microdilution method. Itraconazole and terbinafine alone were inactive against most isolates, but the combination was synergistic against 95 and 85% of isolates after 48 and 72 h of incubation, respectively. Antagonism was not observed. The MICs obtained with the terbinafine-itraconazole combination were within levels that can be achieved in plasma.
authors.affiliation: Department of Medical Microbiology, University Hospital Nijmegen, Nijmegen, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Meletiadis
authors.forename: J W
authors.initials: JW
authors.lastname: Mouton
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez-Tudela
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
authors.forename: P E
authors.initials: PE
authors.lastname: Verweij
mesh_terms: D001203:Ascomycota / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology*; D000077291:Terbinafine
chemical_list: D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine