Development of resistance to chloroform toxicity in male BDF1 mice exposed to a stepwise increase in chloroform concentration.
To investigate the development of resistance to chloroform toxicity, a 4-week inhalation study was conducted in which BDF1 male mice were exposed to a low level of chloroform for an initial two-week period, and thereafter the exposure concentration was increased for a second two-week period. The animals were exposed to inhalation of chloroform vapor 6 hr per day, 5 days per week, with clinical observation and measurement of body weight conducted. These results demonstrate that pre-exposure to chloroform at a low dose level induced resistance to a higher dose of chloroform in male mice. This resistance was dependent on the pre-exposure concentration.
Yamamoto
S
S
Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Kanagawa, Japan.
Nishizawa
T
T
Nagano
K
K
Aiso
S
S
Kasai
T
T
Takeuchi
T
T
Matsushima
T
T
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002725:Chloroform / Q000633:toxicity*; D004361:Drug Tolerance; D004781:Environmental Exposure; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D002725:Chloroform