Induction of heat shock protein 72 protects against organ damage in essential hypertension: A hypothesis.
Over 12 consecutive years, hyperthermia was induced by immersion in hot baths 1576 times in one subject with a long history of labile hypertension. In year 13 (1996), following hyperthermia induction, peripheral lymphocytes were analyzed by Western blot analysis for heat shock protein 72 (HSP72) gene expression. It was demonstrated that rectal and oral fevers maintained for 15 mins at 38.2 C and 38. 6 C or higher, respectively, triggered HSP72 expression. Because this subject showed no evidence of organ damage secondary to hypertension, and because both hyperthermia and acute hypertension upregulate HSP72 expression, a role for HSP72 in protection against the adverse effects of essential hypertension disease is proposed and discussed.
Miller
M J
MJ
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Canada.
Boyd
J E
JE
Gedamu
L
L
D015153:Blotting, Western; D015870:Gene Expression; D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism* / Q000517:prevention & control; D006979:Hyperthermia, Induced; D017382:Reactive Oxygen Species / Q000502:physiology
D050884:HSP72 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D017382:Reactive Oxygen Species