title: Electroencephalography in infants with periventricular leukomalacia: prognostic features at preterm and term age.
abstract: Cystic periventricular leukomalacia represents the most severe white-matter lesion in preterm infants and its occurrence accounts for most cases of neurologic impairment in these subjects. Electroencephalographic (EEG) findings and their prognostic value in relation to motor and cognitive outcome were investigated in a group of preterm infants affected by different degrees of cystic periventricular leukomalacia. EEG recordings were carried out in the early postnatal period (first 2 weeks of life) on 24 infants and at term age on 29. In the early postnatal period, background EEG abnormalities ("dysmaturity") were significantly more apparent in affected infants than in a control group, and, among infants with cystic periventricular leukomalacia, this parameter related to the occurrence of cerebral palsy; moreover, at the same age, the incidence of abnormal EEG transients seemed to show a correlation with cognitive outcome. At term age, these latter abnormalities were significantly more apparent in neonates with cystic periventricular leukomalacia than in control subjects, but they did not show any prognostic value. In conclusion, these data indicate that, during the early postnatal period, the EEG is a useful diagnostic and prognostic tool for preterm infants with white-matter lesions, whereas at term age, the role of EEG tracings appears secondary.
authors.affiliation: Stella Maris Scientific Institute, Division of Child Neurology and Psychiatry, University of Pisa, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Biagioni
authors.forename: L
authors.initials: L
authors.lastname: Bartalena
authors.forename: A
authors.initials: A
authors.lastname: Boldrini
authors.forename: R
authors.initials: R
authors.lastname: Pieri
authors.forename: G
authors.initials: G
authors.lastname: Cioni
mesh_terms: D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D002547:Cerebral Palsy / Q000175:diagnosis / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000503:physiopathology; D007969:Leukomalacia, Periventricular / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D011379:Prognosis