title: Saccharin test of maxillary sinus mucociliary function after endoscopic sinus surgery.
abstract: OBJECTIVE
  To determine the usefulness of the saccharin time (ST) test for evaluating the mucociliary function of the maxillary sinus after endoscopic sinus surgery (ESS) for chronic sinusitis.
  
  
  METHODS
  
  
  
  METHODS
  This study was conducted on 88 maxillary sinuses of 74 patients after ESS. The maxillary sinus fontanel was broadly opened via the middle meatus using an endoscope, and a saccharin granule was adhered to the bottom of the maxillary sinus mucosa The time until the patient recognized the sweet taste was recorded. Before the ST test, the bilateral maxillary sinuses were classified into the following four groups on the basis of the post-ESS severity of mucosal edema and swelling as revealed by endoscopic observation: normal (45 sinuses), mild mucosal edema and swelling (24), moderate mucosal finding (14), and severe mucosal finding or filling of the sinus with a polyp(s) (5).
  
  
  RESULTS
  The mean ST values in the normal group and the groups with mild, moderate, and severe mucosal edema and swelling were 35.7, 38.1, 63.6, and 88.0 minutes, respectively. Thus the ST increased with the post-ESS severity of the mucosal lesion. However, for the group with mild mucosal edema and swelling, scanning electron microscopic observation of three maxillary sinuses in which the ST exceeded 120 minutes and four sinuses in which the ST was 40 minutes revealed extensive cilia loss in the former sinuses, but not in the latter. A second post-ESS endoscopic observation was performed in 17 patients, revealing improvement in 11 sinuses, no change in 5 sinuses, and aggravation in 1 sinus (compared with the initial test). The ST test was also repeated, revealing that the ST became shorter in most of the endoscopically improved sinus group. However, a few sinuses showed a discrepancy between the change in the endoscopic findings and the ciliary function (ST).
  
  
  CONCLUSIONS
  Measurement of the maxillary sinus ST is a simple, accurate, and useful technique for assessing the post-ESS mucociliary function in conjunction with endoscopy, and the information gained can help in deciding subsequent therapy.
authors.affiliation: Department of Otorhinolaryngology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Asai
authors.forename: S
authors.initials: S
authors.lastname: Haruna
authors.forename: N
authors.initials: N
authors.lastname: Otori
authors.forename: K
authors.initials: K
authors.lastname: Yanagi
authors.forename: M
authors.initials: M
authors.lastname: Fukami
authors.forename: H
authors.initials: H
authors.lastname: Moriyama
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002244:Carbon; D002908:Chronic Disease; D004396:Coloring Agents; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000187:drug effects* / Q000503:physiopathology / Q000601:surgery*; D015523:Maxillary Sinusitis / Q000145:classification / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D009079:Mucociliary Clearance / Q000187:drug effects* / Q000502:physiology; D011184:Postoperative Period; D012439:Saccharin; D013997:Time Factors
chemical_list: D004396:Coloring Agents; C028433:chinese ink; D002244:Carbon; D012439:Saccharin