Jumping translocation in acute leukemia of myelomonocytic lineage: a case report and review of the literature.
Jumping translocation (JT) is a very rare cytogenetic event, occurring especially in cancer. We describe a case of secondary acute monocytic leukemia (AML5b) with a JT involving the 3q13-3qter segment and leading to a partial trisomy 3. Each clone with JT was associated with trisomy 8 or tetrasomy 8. The literature of JT in AML cases is reviewed: only 13 cases of AML associated with JT have been previously described, seven of which are AML4/5 FAB subtype. Jumping translocation involvement in leukemogenesis is discussed. Leukemia (2000) 14, 119-122.
Bernard
M
M
Service d'Hématologie Clinique, CHU de Rennes, France.
Lemée
F
F
Picard
F
F
Ghandour
C
C
Drenou
B
B
Le Prise
P Y
PY
Lamy
T
T
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic