[Pathogenetic significance of cholesterol-containing immune complexes and lipid peroxidation in ischemic heart disease].
OBJECTIVE
To ascertain a relationship between cholesterol content in circulating immune complexes (CIC) and plasm lipid peroxidation (LPO) in patients with ischemic heart disease (IHD).


METHODS
Blood samples from 33 IHD patients 23 of which had a history of myocardial infarction and from 8 healthy subjects were examined for total cholesterol, high and low density lipoproteins cholesterol, CIC, the ability of blood serum to induce free radicals, superoxide dismutase.


RESULTS
A statistically significant positive correlation was found between CIC cholesterol level and content of free radicals while a negative correlation existed between superoxide dismutase activity and high density lipoprotein cholesterol level in blood plasm of healthy individuals and patients with IHD. After myocardial infarction an inversion of the above parameters was seen as a result of disorders in both antioxidant and immune systems.


CONCLUSIONS
The level of both LPO and CIC cholesterol, their interaction are important atherogenic factors in development of IHD.
Urazgil'deeva
S A
SA
Shatalina
L V
LV
Gurevich
V S
VS
D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood* / Q000276:immunology; D008078:Cholesterol, LDL / Q000097:blood* / Q000276:immunology; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000276:immunology; D013482:Superoxide Dismutase / Q000097:blood
D000936:Antigen-Antibody Complex; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D016166:Free Radical Scavengers; D013482:Superoxide Dismutase