Interaction of tea catechins with lipid bilayers investigated with liposome systems.
Interaction of tea catechins with lipid bilayers was investigated with liposome systems, which enabled us to separate liposomes from the external medium by centrifugation. We found that epicatechin gallate had the highest affinity for lipid bilayers, followed by epigallocatechin gallate, epicatechin, and epigallocatechin. Epicatechin gallate and epigallocatechin gallate in the surface of lipid bilayer perturbed the membrane structure.
Hashimoto
T
T
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Kumazawa
S
S
Nanjo
F
F
Hara
Y
Y
Nakayama
T
T
D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000378:metabolism; D008051:Lipid Bilayers / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D008956:Models, Chemical; D010636:Phenols / Q000378:metabolism; D011108:Polymers / Q000378:metabolism; D013662:Tea
D005419:Flavonoids; D008051:Lipid Bilayers; D008081:Liposomes; D010636:Phenols; D011108:Polymers; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; C057580:gallocatechol