[Parameters of blood proteinase inhibitor balance and hyperlipoproteinemia in patients with proliferative diabetic retinopathy with vitreous hemorrhage].
The parameters of proteinase-inhibitor balance and lipid metabolism were studied in the blood of patients with proliferative diabetic retinopathy. Metabolic disorders in patients with proliferative diabetic retinopathy with hemophthalmia are characterized by a notable increase in the activities of trypsin-like enzymes and alpha 2-macroglobulin level and normal activity of alpha 1-antitrypsin and shifted lipid metabolism parameters characteristic of types IIb and IV hyperlipoproteinemia. These data indicate a necessity of monitoring lipid metabolism and proteinase-inhibitor balance in patients with diabetic retinopathy in order to detect subjects at a high risk of hemophthalmia and timely start drug correction for preventing this complication.
Chesnokova
N B
NB
Kuznetsova
T P
TP
Davydova
G A
GA
Grigor'ev
A V
AV
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications; D003930:Diabetic Retinopathy / Q000097:blood* / Q000150:complications / Q000517:prevention & control; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011480:Protease Inhibitors / Q000097:blood*; D014357:Trypsin / Q000097:blood; D014823:Vitreous Hemorrhage / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D000511:alpha-Macroglobulins / Q000378:metabolism
D015415:Biomarkers; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011480:Protease Inhibitors; D000511:alpha-Macroglobulins; D014357:Trypsin