title: Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients.
abstract: To determine the frequency of in vivo activated T(H)1 lymphocytes, T-cell subsets of 9 multiple sclerosis patients with active disease and 17 healthy controls were analyzed by immunostaining for CCR5, CD26, and their expression of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha. The numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-producing T cells were significantly increased in the peripheral blood of multiple sclerosis patients. CCR5 expression may be a useful marker to identify effector cells in multiple sclerosis and could be used as a tool for monitoring disease activity.
authors.affiliation: Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Strunk
authors.forename: S
authors.initials: S
authors.lastname: Bubel
authors.forename: B
authors.initials: B
authors.lastname: Mascher
authors.forename: P
authors.initials: P
authors.lastname: Schlenke
authors.forename: H
authors.initials: H
authors.lastname: Kirchner
authors.forename: K P
authors.initials: KP
authors.lastname: Wandinger
mesh_terms: D000328:Adult; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism*; D015759:Ionomycin / Q000494:pharmacology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology; D019713:Receptors, CCR5 / Q000378:metabolism*; D012016:Reference Values; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D019713:Receptors, CCR5; D014409:Tumor Necrosis Factor-alpha; D015759:Ionomycin; D007371:Interferon-gamma; D018819:Dipeptidyl Peptidase 4; D013755:Tetradecanoylphorbol Acetate