[Changes in tissue insulin sensitivity under the action of potable mineral waters (clinico-experimental research)].
The trial included 43 Wistar rats with alloxan diabetes, 80 patients with impaired carbohydrate tolerance, 80 patients with non-insulin-dependent diabetes mellitus (NIDDM). 22 healthy volunteers and 60 intact rats served control. Glucose levels were measured 10, 20, 30, 45, 60, 90 and 120 minutes after insulin administration (3.7 U/m2). It was found that insulin resistance in impaired carbohydrate tolerance was higher than in diabetes. Mineral water intake improves recovery of sensitivity to insulin. This improvement was more evident in intact rats. Therefore, mineral water is a good prophylactic modality.
Polushina
N D
ND
Botvineva
L A
LA
Frolkov
V K
VK
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000534:rehabilitation; D004353:Drug Evaluation, Preclinical; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000534:rehabilitation; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D007333:Insulin Resistance; D008297:Male; D008900:Mineral Waters / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008900:Mineral Waters