Structure and function of dopamine receptors.
Dopamine (DA) is the most abundant catecholamine in the brain. The involvement and importance of DA as a neurotransmitter in the regulation of different physiological functions in the central nervous system (CNS) is well known. Deregulation of the dopaminergic system has been linked with Parkinson's disease, Tourette's syndrome, schizophrenia, attention deficit hyperactive disorder (ADHD) and generation of pituitary tumours. This review focuses on the pharmacological and biochemical features shared by the dopamine receptors. We address their coupling to secondary messenger pathways and their physiological function based upon studies using pharmacological tools, specific brain lesions and, more recently, genetically modified animal models.
Vallone
D
D
Institut de Génétique et de Biologie Moléculaire et Cellulaire. CNRS/INSERM/ULP, BP 163, Illkirch, C. U. de Strasbourg, France.
Picetti
R
R
Borrelli
E
E
D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D011487:Protein Conformation; D011954:Receptors, Dopamine / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
D011954:Receptors, Dopamine; D004298:Dopamine