The ADAM gene family: surface proteins with adhesion and protease activity.
An ADAM is a transmembrane protein that contains a disintegrin and metalloprotease domain and, therefore, it potentially has both cell adhesion and protease activities. Currently, the ADAM gene family has 29 members, although the function of most ADAM gene products is unknown. We discuss the ADAM gene products with known functions that act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response.
Primakoff
P
P
Department of Cell Biology and Anatomy, School of Medicine, University of California, Davis, CA 95616, USA. pdprimakoff@ucdavis.edu
Myles
D G
DG
D051722:ADAM Proteins; D000818:Animals; D002448:Cell Adhesion / Q000235:genetics; D000072196:Fertilins; D005306:Fertilization / Q000235:genetics; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics*; D008666:Metalloendopeptidases / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D005810:Multigene Family; D017434:Protein Structure, Tertiary
D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D051722:ADAM Proteins; D000072196:Fertilins; D008666:Metalloendopeptidases