title: Bioactive tantalum metal prepared by NaOH treatment.
abstract: Untreated tantalum metal formed an apatite on its surface in simulated body fluid (SBF) with ion concentrations nearly equal to those of human blood plasma. However, it took an induction period as long as 4 weeks for apatite formation. The tantalum metal formed the apatite within 1 week when it was previously soaked in a 0.2 or 0.5M NaOH aqueous solution at 60 degrees C for 24 h to form a sodium tantalate hydrogel layer on its surface. The decrease in the induction period of apatite formation was attributed to the catalytic effect of the Ta-OH groups on the surface of the tantalum metal for apatite nucleation and acceleration of the apatite nucleation by an increased ionic activity product of the apatite in the fluid due to the release of Na(+) ions. The NaOH-treated tantalum metal can form apatite in a short period even in the living body and bond to the bone through this apatite layer. This indicates that a highly bioactive tantalum metal can be obtained by a simple chemical treatment.
authors.affiliation: Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Sakyo-Ku, Kyoto 606-8501, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: F
authors.initials: F
authors.lastname: Miyaji
authors.forename: T
authors.initials: T
authors.lastname: Kokubo
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D001031:Apatites / Q000097:blood* / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001826:Body Fluids; D005782:Gels; D006801:Humans; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000097:blood* / Q000737:chemistry*; D012972:Sodium Hydroxide; D013635:Tantalum / Q000097:blood* / Q000737:chemistry*
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D005782:Gels; D007202:Indicators and Reagents; D010087:Oxides; C404416:sodium tantalate; D012972:Sodium Hydroxide; D013635:Tantalum