Gene-gene interaction in the RAS system in the predisposition to myocardial infarction in elder population of St. Petersburg (Russia).
The aim of this study was to estimate the frequencies of some DNA polymorphisms of two genes of the renin-angiotensin system (RAS), M235T angiotensinogen gene and insertion-deletion polymorphism in angiotensin-converting enzyme gene, in older (>55 years old) myocardial infarction survival and control groups. For this purpose 198 myocardial infarction (MI) patients and 152 randomly selected healthy persons have been analyzed. We have not found any differences in allele and genotype distribution in the above-mentioned genes for either group. However, statistical research showed a significant increase of double homozygotes IITT in the group of MI patients as compared with those in the control group. In this respect we suggested that gene-gene interaction in the RAS system may be considered to be a predisposing factor for MI development.
Fomicheva
E V
EV
Laboratory of Human Molecular Genetics, St. Petersburg Institute of Nuclear Physics, RAS, Gatchina, St. Petersburg area, 188350, Russia.
Gukova
S P
SP
Larionova-Vasina
V I
VI
Kovalev
Y R
YR
Schwartz
E I
EI
D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D000808:Angiotensinogen / Q000235:genetics*; D002648:Child; D004843:Epistasis, Genetic; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000401:mortality; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D012084:Renin-Angiotensin System / Q000235:genetics*; D012426:Russia; D017384:Sequence Deletion / Q000235:genetics
D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A