title: In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model.
abstract: The hypothalamic functional MRI (fMRI) response in an animal model was studied following energy intake. Six fasted (12 h) Sprague-Dawley (SD) rats were administered an intraperitoneal injection of glucose (0.72 grams/kg body weight), while a mid-sagittal slice through the hypothalamus was continuously imaged for 60 min using a conventional T2*-weighted gradient-echo sequence. All rats demonstrated a significant acute transient decrease in the fMRI signal intensity (mean: 3.4%) in the hypothalamic region within 12-16 min after intraperitoneal glucose injection. The SD rat may be a suitable model for future fMRI studies of the hypothalamus involving the administration of exogenous nutrients and medications.
authors.affiliation: Research Imaging Center, University of Texas Health Science Center, San Antonio 78284-6240, USA.
authors.forename: S
authors.initials: S
authors.lastname: Mahankali
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Pu
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: C W
authors.initials: CW
authors.lastname: Chen
authors.forename: P T
authors.initials: PT
authors.lastname: Fox
authors.forename: J H
authors.initials: JH
authors.lastname: Gao
mesh_terms: D000818:Animals; D016477:Artifacts; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D007089:Image Enhancement / Q000379:methods*; D007274:Injections, Intraperitoneal; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012680:Sensitivity and Specificity
chemical_list: D005947:Glucose