Broadsheet number 52: Molecular genetics of colorectal cancer.
The molecular genetics of colorectal cancer is presented in an order that ascends from the basic to the applied: molecular mechanisms, morphogenesis, classification and diagnosis. Major consideration is given to the nature of genetic instability and the role of this mechanism in driving neoplastic progression. It is shown how the fundamental principle of genetic instability cuts across applied research, tissue diagnosis and clinical management with respect to both sporadic and inherited forms of colorectal cancer.
Jass
J R
JR
Department of Pathology, University of Queensland Medical School, Brisbane, Australia. j.jass@mailbox.uq.edu.au
D000230:Adenocarcinoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D005819:Genetic Markers; D005820:Genetic Testing; D006801:Humans; D008967:Molecular Biology; D009626:Terminology as Topic
D005819:Genetic Markers