title: [Distemper of carnivore: Proliferative activity of lymphocytes in sick and vaccinated dogs].
abstract: Effect of inoculation with canine distemper virus (CDV) strains of various virulence or vaccination with commercial polyvalent preparations on the immune status of puppies has been studied. Serum interferon concentration did not change, irrespective of the strain appurtenance of CDV, while the concentration of tumor necrosis factor-alpha decreased on days 4-14 after the virus inoculation. According to the lymphocyte stimulation test (LST), virulent strain Snyder Hill and reactogenic variant U were characterized by a pronounced immunosuppressive effect. Vaccine strain VNiiViM-88 exerted a stimulating effect in LST. Vanguard 5/L vaccine suppressed the immunity for up to 2 weeks. Vacchum, VNiiViM, and experimental vaccine manufactured by a joint-stock company Vetzverotsentr+ activated the mitogen-induced lymphocyte blastogenesis.
authors.forename: A D
authors.initials: AD
authors.lastname: Sereda
authors.forename: K E
authors.initials: KE
authors.lastname: Gavrilov
authors.forename: L G
authors.initials: LG
authors.lastname: Fugina
mesh_terms: D000818:Animals; D004216:Distemper / Q000276:immunology* / Q000517:prevention & control*; D004217:Distemper Virus, Canine; D004285:Dogs; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D014765:Viral Vaccines