[Isolation of acyclovir-resistant strains of herpes simplex virus from clinical material].
A total of 115 strains of herpes simplex virus were isolated from clinical material collected in patients with genital herpes. The majority (93%) of isolated strains were sensitive to acyclovir: ID50 varied from 0.15 to 0.80 microgram/ml acyclovir. Eleven (7%) strains from 4 patients were resistant to acyclovir: ID50 was 30-125 times higher in comparison with the reference HSV-1 strain L2.
L'vov
N D
ND
Andronova
V L
VL
Leont'eva
N A
NA
Galegov
G A
GA
D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D004352:Drug Resistance, Microbial; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D018139:Simplexvirus / Q000187:drug effects* / Q000302:isolation & purification; D014709:Vero Cells
D000998:Antiviral Agents; D000212:Acyclovir