title: Endovascular repair of descending thoracic aortic aneurysms: an early experience with intermediate-term follow-up.
abstract: OBJECTIVE
  The purpose of this study was to report an initial experience with the endovascular repair of descending thoracic aortic aneurysm. Complications and intermediate-term morphologic changes were identified with the intent of altering patient selection and device design.
  
  
  METHODS
  Endografts were placed into 25 patients at high-risk for conventional surgical repair over a 3(1/2)-year period. Devices were customized on the basis of preoperative imaging information. Follow-up computed tomography scans were obtained at 1, 3, 6, and 12 months and yearly thereafter. Additional interventions occurred in the setting of endoleaks, migration, and aneurysm growth.
  
  
  RESULTS
  The overall 30-day mortality rate was 20% (12.5% for elective cases; 33% for emergent cases). There were 3 conversions to open repair. Neurologic deficits developed in 3 patients; 1 insult resulted in permanent paraplegia. Neurologic deficits were associated with longer endografts (P =.019). Three endoleaks required treatment, and 1 fatal rupture of the thoracic aneurysm treated occurred 6 months after the initial repair. Migrations were detected in 4 patients. The maximal aneurysm size decreased yearly by 9.15% (P =.01) or by 13.5% (P =.0005) if patients with endoleaks (n = 3 patients) were excluded. Both the proximal and distal neck dilated slightly over the course of follow-up (P =.019 and P =.001, respectively). The length of the proximal neck was a significant predictor of the risk for endoleakage (P =.02).
  
  
  CONCLUSIONS
  The treatment of descending thoracic aortic aneurysms with an endovascular approach is feasible and may, in some patients, offer the best means of therapy. Early complications were primarily related to device design and patient selection. All aneurysms without endoleaks decreased in size after treatment. Late complications were associated with changing aneurysm morphologic features and device migration. The morphologic changes remain somewhat unpredictable; however, alterations in device design may result in improved fixation and more durable aneurysm exclusion.
authors.affiliation: Department of Vascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: R
authors.initials: R
authors.lastname: Greenberg
authors.forename: T
authors.initials: T
authors.lastname: Resch
authors.forename: U
authors.initials: U
authors.lastname: Nyman
authors.forename: M
authors.initials: M
authors.lastname: Lindh
authors.forename: J
authors.initials: J
authors.lastname: Brunkwall
authors.forename: P
authors.initials: P
authors.lastname: Brunkwall
authors.forename: M
authors.initials: M
authors.lastname: Malina
authors.forename: B
authors.initials: B
authors.lastname: Koul
authors.forename: B
authors.initials: B
authors.lastname: Lindblad
authors.forename: K
authors.initials: K
authors.lastname: Ivancev
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography; D017130:Angioplasty / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods* / Q000401:mortality; D017545:Aortic Aneurysm, Thoracic / Q000145:classification / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D015897:Comorbidity; D005500:Follow-Up Studies; D005548:Foreign-Body Migration / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology; D018579:Patient Selection; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D012307:Risk Factors; D012720:Severity of Illness Index; D015607:Stents / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome