title: Recent advances in liquid-phase combinatorial chemistry.
abstract: In combination with high throughput screening, combinatorial organic synthesis of large numbers of pharmaceutically interesting compounds may revolutionize the drug discovery process. Although combinatorial organic synthesis on solid supports is a useful approach, several groups are focusing their research efforts on liquid-phase combinatorial synthesis by the use of soluble polymer supports to generate libraries. This macromolecular carrier, in contrast to an insoluble matrix, is soluble in most organic solvents and has a strong tendency for precipitation in particular solvents. Liquid-phase combinatorial synthesis is a unique approach since homogeneous reaction conditions can be applied, but product purification similar to the solid-phase method can be carried out by simple filtration and washing. This method combines the positive aspects of classical solution-phase chemistry and solid-phase synthesis. This review examines the recent applications (1995-1999) of soluble polymer supports in the synthesis of combinatorial libraries.
authors.affiliation: Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Tiawan. cmsun@mail.ndhu.edu.tw
authors.forename: C M
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000588:Amines / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques / Q000379:methods* / Q000639:trends*; D015195:Drug Design; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D000588:Amines; D010455:Peptides