title: Computational study of the effect of geometric and flow parameters on the steady flow field at the rabbit aorto-celiac bifurcation.
abstract: Arterial hemodynamic forces may play a role in the localization of early atherosclerotic lesions. We have been developing numerical techniques based on overset or "Chimera" type formulations to solve the Navier-Stokes equations in complex geometries simulating arterial bifurcations. This paper presents three-dimensional steady flow computations in a model of the rabbit aorto-celiac bifurcation. The computational methods were validated by comparing the numerical results to previously-obtained flow visualization data. Once validated, the numerical algorithms were used to investigate the sensitivity of the computed flow field and resulting wall shear stress distribution to various geometric and hemodynamic parameters. The results demonstrated that a decrease in the extent of aortic taper downstream of the celiac artery induced looping fluid motion along the lateral walls of the aorta and shifted the peak wall shear stress from downstream of the celiac artery to upstream. Increasing the flow Reynolds number led to a sharp increase in spatial gradients of wall shear stress. The flow field was highly sensitive to the flow division ratio, i.e., the fraction of total flow rate that enters the celiac artery, with larger values of this ratio leading to the occurrence of flow separation along the dorsal wall of the aorta. Finally, skewness of the inlet velocity profile had a profound impact on the wall shear stress distribution near the celiac artery. While not physiological due to the assumption of steady flow, these results provide valuable insight into the fluid physics at geometries simulating arterial bifurcations.
authors.affiliation: Department of Mathematics, University of California, Davis 95616, USA.
authors.forename: A Y
authors.initials: AY
authors.lastname: Cheer
authors.forename: H A
authors.initials: HA
authors.lastname: Dwyer
authors.forename: A I
authors.initials: AI
authors.lastname: Barakat
authors.forename: E
authors.initials: E
authors.lastname: Sy
authors.forename: M
authors.initials: M
authors.lastname: Bice
mesh_terms: D000465:Algorithms; D000818:Animals; D001011:Aorta; D001161:Arteriosclerosis / Q000503:physiopathology; D001698:Biomedical Engineering; D002445:Celiac Artery; D019295:Computational Biology; D006439:Hemodynamics; D008955:Models, Cardiovascular; D011817:Rabbits; D013314:Stress, Mechanical