title: The Tec family protein-tyrosine kinases: a subset of kinases for a subset of signalings.
abstract: The Tec family has emerged recently as a subfamily among nonreceptor type protein-tyrosine kinases, consisting of Tec, Btk, Itk/Tsk/Emt, Bmx, and Txk/Rlk. Because many members of this family have been shown to be activated in response to growth and differentiation stimuli in hematopoietic tissues, they are presumed to function in vivo as important signaling mediators. Although that hypothesis was further strengthened by the knowledge that mutations in Btk cause agammaglobulinemia in humans, we have only limited information concerning the molecular interaction through which Tec kinases exert their effects. One characteristic feature of Tec family members is the presence of a pleckstrin homology domain in their protein structure, suggesting a physical and functional interaction with the phospholipid-dependent signaling pathways. Recent data have revealed that Tec kinases regulate phospholipase C isoforms. This review summarizes current knowledge concerning the in vivo roles of the Tec family proteins.
authors.affiliation: Department of Molecular Biology, Jichi Medical School, Tochigi, Japan. hmano@jichi.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Mano
mesh_terms: D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D020013:Calcium Signaling; D004331:Drosophila melanogaster / Q000196:embryology / Q000201:enzymology / Q000235:genetics; D019143:Evolution, Molecular; D016762:Genes, fos; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D009024:Morphogenesis / Q000502:physiology; D005810:Multigene Family; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*; D019061:src-Family Kinases / Q000502:physiology
chemical_list: D019476:Insect Proteins; D016760:Proto-Oncogene Proteins c-fos; C492367:BMX protein, human; C492366:Bmx protein, mouse; C089848:Tec protein-tyrosine kinase; C113193:Tec29 protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; C080813:emt protein-tyrosine kinase; D019061:src-Family Kinases