Reptilian paramyxoviruses induce cytokine production in human leukocytes.
The reptilian paramyxoviruses FDLV and GOV initiated the production and release of cytokines like IL-1alpha, IL-1beta, IL-2, TNF-alpha and IFN-alpha in human peripheral blood mononuclear cells (PBMC) at 37 degrees C. The target cells produced the cytokines without replication of virus.
Ahne
W
W
Faculty of Veterinary Medicine, University of Munich, Germany. ahne@lrz.uni-muenchen.de
Mayr
A
A
D000818:Animals; D017837:Bothrops / Q000821:virology*; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D017815:Elapidae / Q000821:virology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D006801:Humans; D007076:Iguanas; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000821:virology; D008854:Microscopy, Electron / Q000662:veterinary; D018108:Respirovirus / Q000276:immunology* / Q000648:ultrastructure; D010253:Respirovirus Infections / Q000662:veterinary* / Q000821:virology; D013696:Temperature; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma