title: [The Italian Registry of Bone Marrow Donors: genetic structure and recruitment strategy].
abstract: The genetic structure of the Italian bone marrow donor population was analysed by estimating the HLA-A, -B and -DR gene and haplotype frequencies for the total population and for the Italian administrative regions. The haplotype frequencies were used to predict the probability of finding HLA-compatible donors for Italian patients depending on the registry size, and the probability of recruiting in the different Italian regions a donor with a new phenotype. The analysis of these probabilities allows us to propose strategies for donors recruitment in order to increase the phenotypic variability of the registry, then its efficiency.
authors.affiliation: Servizio di Immunologia dei Trapianti, Ospedale Molinette, Torino.
authors.forename: S
authors.initials: S
authors.lastname: Rendine
authors.forename: M
authors.initials: M
authors.lastname: Barbanti
authors.forename: I
authors.initials: I
authors.lastname: Borelli
authors.forename: A M
authors.initials: AM
authors.lastname: Dall'Omo
authors.forename: S
authors.initials: S
authors.lastname: Roggero
authors.forename: N
authors.initials: N
authors.lastname: Sacchi
authors.forename: E S
authors.initials: ES
authors.lastname: Curtoni
mesh_terms: D000465:Algorithms; D001853:Bone Marrow / Q000276:immunology; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006650:Histocompatibility Testing / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy; D012042:Registries / Q000706:statistics & numerical data*
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens