[Correlation of morphologic changes between optical coherence tomography and topographic angiography in a case of gyrate atrophy].
OBJECTIVE
To characterize ultrastrructual changes in atrophic disease of the retina, RPE and choroid as seen with gyrate atrophy using two new diagnostic modalities, optical coherence tomography (OCT) and topographic angiography.


METHODS
OCT images were taken in a patient with pericentral choroidal atrophy using a slit-lamp-adapted OCT system. Ophthalmoscopy, conventional and topographic angiographic findings were correlated to the reflectivity changes as seen on OCT.


RESULTS
Areas of chorioretinal atrophy correlated with a loss of reflectivity in the RPE-choriocapillaris complex on OCT. Additionally OCT identified a thinning of the nerve fiber layer. Topographic angiography demonstrated an extensive defect, seen as an area of depression, consistent with a loss of choriocapillaris and larger-sized choroidal vessels. In contrast to conventional angiography, central islands were not found to demonstrate structural intensity, while the midperipheral surrounding area was clearly elevated to physiological levels.


CONCLUSIONS
OCT and topographic angiography provide in vivo insight into morphologic changes within neurosensory retina and choroid caused by pericentral choroidal atrophy.
Meyer
C H
CH
Universitäts-Augenklinik zu Lübeck.
Hoerauf
H
H
Schmidt-Erfurth
U
U
Roider
J
J
Scholz
C
C
Laqua
H
H
Birngruber
R
R
D002829:Choroid / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D015799:Gyrate Atrophy / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D014054:Tomography / Q000379:methods*