title: Cooperation between HGF and CNTF in promoting the survival and growth of sensory and parasympathetic neurons.
abstract: Previous studies have shown that hepatocyte growth factor (HGF) enhances the survival and growth of neurons that depend on NGF for survival. To determine if HGF cooperates with other neurotrophic factors in the developing peripheral nervous system, we studied the effect of HGF on parasympathetic ciliary ganglion neurons and proprioceptive trigeminal mesencephalic nucleus (TMN) neurons, both of which survive with CNTF. HGF did not promote the survival of these neurons on its own but did enhance the number that survived with CNTF and increased the length and branching of their neurite arbors. HGF did not, however, enhance the survival and growth of TMN neurons incubated with BDNF, which promoted their survival as effectively as CNTF. These results show that HGF cooperates with CNTF in promoting the survival and growth of parasympathetic and proprioceptive neurons and that within the same neurons, the effects of HGF on survival and growth are selectively dependent on which other signaling pathways are concurrently activated.
authors.affiliation: School of Biomedical Sciences, University of St. Andrews, Bute Medical Buildings, St. Andrews, Fife, KY16 9TS, Scotland, United Kingdom.
authors.forename: F
authors.initials: F
authors.lastname: Davey
authors.forename: M
authors.initials: M
authors.lastname: Hilton
authors.forename: A M
authors.initials: AM
authors.lastname: Davies
mesh_terms: D000818:Animals; D001369:Axons / Q000187:drug effects / Q000502:physiology; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D002642:Chick Embryo; D020934:Ciliary Neurotrophic Factor / Q000494:pharmacology*; D017228:Hepatocyte Growth Factor / Q000494:pharmacology*; D007700:Kinetics; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000187:drug effects; D009475:Neurons, Afferent / Q000166:cytology* / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000166:cytology*
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D020934:Ciliary Neurotrophic Factor; D017228:Hepatocyte Growth Factor