Sliding clamps: a (tail)ored fit.
New structural information on the architecture of a DNA replisome provides insights into a number of DNA metabolic processes and their modulation by circular 'sliding damps', which form rings around DNA that play an Important role in processive processes such as replication.
Hingorani
M M
MM
The Rockefeller University, New York, New York 10021, USA. manju@mod.rockefeller.edu
O'Donnell
M
M
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D003090:Coliphages / Q000201:enzymology / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D018809:Proliferating Cell Nuclear Antigen / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D013329:Structure-Activity Relationship
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004268:DNA-Binding Proteins; D018809:Proliferating Cell Nuclear Antigen; D004247:DNA; D004259:DNA-Directed DNA Polymerase