Acute phase response to nitroprusside-induced controlled hypotension in patients undergoing radical prostatectomy.
This study evaluated the effects of sodium nitroprusside-induced controlled hypotension on the acute phase response in patients undergoing radical prostatectomy. Thirty patients were randomly allocated to two groups, a hypotension group (mean arterial blood pressure was adjusted to 50 mmHg) and a control group (mean arterial blood pressure > 70 mmHg). C-reactive protein increased significantly in the hypotension group from 0.13 (0.23) to 9.85 (2.84) microg x ml-1 and in the control group from 0.15 (0.27) to 7.38 (3.02) microg x ml-1. In both groups, serum amyloid A increased significantly, but levels were higher in the hypotension group [585 (125) microg x l-1] than in the control group [460 (187) microg x l-1]. Interleukin-6 increased significantly in both groups, but was higher in the hypotension group [139 (124) pg x ml-1] than the control group [56 (27) pg x ml-1]. Elastase showed no significant changes in the control group but in the hypotension group there was a significant increase from 65 (51) to 122 (75) ng x ml-1. Sodium nitroprusside-induced hypotension was associated with a more pronounced acute phase reaction.
Piper
S N
SN
Department of Anaesthesiology and Intensive Care Medicine, Hospital of the City Ludwigshafen, Germany.
Suttner
S W
SW
Schmidt
C C
CC
Kumle
B
B
Maleck
W H
WH
Boldt
J
J
D000209:Acute-Phase Proteins / Q000032:analysis; D000210:Acute-Phase Reaction / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016063:Blood Loss, Surgical; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D007023:Hypotension, Controlled; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009599:Nitroprusside; D010196:Pancreatic Elastase / Q000097:blood; D011468:Prostatectomy / Q000379:methods; D014665:Vasodilator Agents
D000209:Acute-Phase Proteins; D015415:Biomarkers; D015850:Interleukin-6; D014665:Vasodilator Agents; D009599:Nitroprusside; D002097:C-Reactive Protein; D010196:Pancreatic Elastase