title: [1977 mortality rate in HIV-infected patients presenting with hepatitis C cirrhosis. Results of the GERMIVC multicenter survey conducted in French departments of internal medicine or infectious disease].
abstract: OBJECTIVE
  Hepatitis C (HCV) has a high prevalence (10-30%) among human immunodeficiency virus (HIV)-infected patients. However, little information is available regarding the impact of hepatitis C on survival. The objective of our study was to determine the incidence of hepatitis C-related deaths in HIV-HCV co-infected patients.
  
  
  METHODS
  The study was a retrospective (1-year), multicenter cohort survey conducted in 63 departments of either internal medicine or infectious diseases in France. It included 26,497 HIV-infected patients, of whom 4,465 (16.8%) presented coinfection due to the hepatitis C virus. The following parameters were studied for the year 1997: total number of deaths, number of deaths related to either AIDS, cirrhosis, hepatocellular carcinoma, or other causes.
  
  
  RESULTS
  Among the 26,497 patients, 543 deaths (incidence: 2%) were observed in 1997; 543 deaths were due to AIDS (incidence: 1.7%), 36 to cirrhosis and/or hepatocellular carcinoma (incidence: 0.13%), and 48 (incidence: 0.18%) to another cause. In the subgroup including 4,465 HIV-HCV-coinfected patients, 29 deaths (incidence: 0.64%) were due to either HCV-related cirrhosis or hepatocellular carcinoma. These results were compared with those of a previous similar survey conducted in 1995, before the era of highly active antiretroviral therapy. The only significant difference is the dramatic regression of deaths due to AIDS.
  
  
  CONCLUSIONS
  The impact of hepatitis C virus on the mortality among HIV-infected patients whose follow-up took place in departments of either internal medicine or infectious diseases in France was very low in 1997. The expected increase in the life span in these patients could modify these results in the future, due to recent improvements in the HIV infection treatment.
authors.affiliation: Hôpital de Compiègne, Nice, France.
authors.forename: L
authors.initials: L
authors.lastname: Geffray
authors.forename: E
authors.initials: E
authors.lastname: Rosenthal
authors.forename: P
authors.initials: P
authors.lastname: Cacoub
authors.forename: C
authors.initials: C
authors.lastname: Perronne
authors.forename: P
authors.initials: P
authors.lastname: Veyssier
authors.forename: G
authors.initials: G
authors.lastname: Raguin
authors.forename: R
authors.initials: R
authors.lastname: Cevallos
authors.forename: O
authors.initials: O
authors.lastname: Patey
authors.forename: O
authors.initials: O
authors.lastname: Bouchard
authors.forename: I
authors.initials: I
authors.lastname: Loury
authors.forename: E
authors.initials: E
authors.lastname: Delarocque
authors.forename: C
authors.initials: C
authors.lastname: Goujard
authors.forename: J M
authors.initials: JM
authors.lastname: Estavoyer
authors.forename: C
authors.initials: C
authors.lastname: Dupont
authors.forename: M
authors.initials: M
authors.lastname: Grappin
authors.forename: P
authors.initials: P
authors.lastname: Morand
authors.forename: H
authors.initials: H
authors.lastname: Laurichesse
authors.forename: D
authors.initials: D
authors.lastname: Vuitton
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000150:complications / Q000401:mortality*; D006801:Humans; D007388:Internal Medicine; D008017:Life Expectancy; D008103:Liver Cirrhosis / Q000209:etiology / Q000401:mortality*; D008297:Male; D015996:Survival Rate