title: Fluorescence in situ hybridization identifies inversion 16 masked by t(10;16)(q24;q22), t(7;16)(q21;q22), and t(2;16)(q37;q22) in three cases of AML-M4Eo.
abstract: Bone marrow or peripheral blood from three patients had a t(10;16)(q24;q22), t(7;16) (q21;p13.1), and t(2;16)q37;q22), respectively. In all cases, fluorescence in situ hybridization confirmed an inv(16) masked by the translocation. The three patients were diagnosed with acute myelomonocytic leukemia and increased eosinophils. Because inv(16) has a favorable prognosis, identification of masked inv(16) will promote improved management of these cases. Therefore, all cases that have atypical rearrangement of chromosome 16 should be investigated for a possible inversion.
authors.affiliation: Department of Genetics, Quest Diagnostics Inc., San Juan Capistrano, CA 92690, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Montgomery
authors.forename: W
authors.initials: W
authors.lastname: Grove
authors.forename: L E
authors.initials: LE
authors.lastname: Robertson
mesh_terms: D000328:Adult; D001854:Bone Marrow Cells / Q000473:pathology; D007446:Chromosome Inversion; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics*