[The immunomodulating activity of the heteropolysaccharides from German chamomile (Matricaria chamomilla) during air and immersion cooling].
Intragastric and parenteral administration of heteropolysaccharides of Matricaria chamomilla L. is found to normalize developing of the immune response upon air cooling and enhance (but do not normalize) this process upon immersion cooling. The immunomodulating effect of the heteropolysaccharides upon cooling is attributed to initiation of immunostimulating properties of heavy erythrocytes (macrocytes), activization of immunoregulation cells of peripheral blood, and increased sensitivity of effector cells to helper signals.
Uteshev
B S
BS
Russian State Medical University, Moscow, Russia.
Laskova
I L
IL
Afanas'ev
V A
VA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000388:Air; D000818:Animals; D020843:Chamomile; D003080:Cold Temperature / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006571:Heterocyclic Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D007101:Immersion / Q000009:adverse effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization / Q000379:methods; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric
D000276:Adjuvants, Immunologic; D006571:Heterocyclic Compounds; D011134:Polysaccharides