title: Experimental study of mechanical microvascular anastomosis with new biodegradable ring device.
abstract: The commercially available mechanical vascular anastomotic device with ring-pin technique employs polyethylene rings and stainless steel pins, but even after healing of the anastomotic site, the ring remains. To resolve this disadvantage, the ring material was replaced by biodegradable material, and a ring coupling device was fabricated. This new ring was used to anastomose the femoral vein of rabbits, and morphological observations were made macroscopically and by light and scanning electron microscopy. Of the 58 anastomosed veins, 54 were patent, giving a patency rate of 92.9%. The ring was largely absorbed 15 weeks after anastomosis and completely after 30 weeks. Histologically, re-endothelialisation was observed in 1 week. Infiltration of inflammatory cells was significant around the ring at 3 weeks, but inflammation subsided within 6 weeks. There were no findings indicating adverse effects of the stainless steel pins remaining outside the vascular wall.
authors.affiliation: Department of Orthopaedic Surgery, Hiroshima University School of Medicine, Hiroshima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Joji
authors.forename: H
authors.initials: H
authors.lastname: Muneshige
authors.forename: Y
authors.initials: Y
authors.lastname: Ikuta
mesh_terms: D020341:Absorbable Implants; D000714:Anastomosis, Surgical / Q000295:instrumentation* / Q000379:methods; D000818:Animals; D004730:Endothelium, Vascular / Q000648:ultrastructure; D005069:Evaluation Studies as Topic; D005268:Femoral Vein / Q000601:surgery* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013997:Time Factors