MRI study of human brain exposed to high-dose repetitive magnetic stimulation of visual cortex.
T1-, T2-, and diffusion-weighted MRI was used to determine whether repetitive transcranial magnetic stimulation (rTMS) affects the blood-brain barrier or induces localized brain edema. In 11 healthy individuals, 1,200 to 3,800 stimuli were applied over the visual cortex of one hemisphere in series of 5-, 10-, or 20-Hz stimulus trains. MRI performed 6 minutes to 6 hours after rTMS did not show pathologic changes in conventional MRI sequences, after application of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA), or by determining apparent diffusion coefficients.
Niehaus
L
L
Department of Neurology, Charité, Campus Virchow Klinikum, Humboldt-University, Berlin, Germany.
Hoffmann
K T
KT
Grosse
P
P
Röricht
S
S
Meyer
B U
BU
D000328:Adult; D001812:Blood-Brain Barrier / Q000502:physiology; D001834:Body Water / Q000378:metabolism; D001929:Brain Edema / Q000175:diagnosis / Q000209:etiology; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D010719:Phosphenes / Q000502:physiology; D010812:Physical Stimulation / Q000379:methods; D014793:Visual Cortex / Q000033:anatomy & histology* / Q000502:physiology*
D003287:Contrast Media; D019786:Gadolinium DTPA