title: Comparison of self-reinforced poly-L-lactide and steel wire in fixation of sternotomy in rabbits.
abstract: OBJECTIVE
  To investigate the healing of sternotomies fixed with biodegradable self-reinforced poly-L-lactide (SR-PLLA) wire and comparing it with steel wire fixation.
  
  
  METHODS
  Sixteen rabbits (15 Chinchilla and one New Zealand White rabbit) were operated on. Two parallel holes of 1.5 mm in diameter were drilled in the sternum at the level of the second and third rib and similar holes of 0.8 mm were drilled at the level of the third and fourth rib. A transverse sternotomy was created between both drill hole pairs. The sternotomy with larger drill holes was fixed with 1.1-mm thick SR-PLLA wire. The sternotomy between the smaller drill holes was fixed using 2.0 steel wire. The animals were sacrificed at 2, 7, 26 and 52 weeks postoperatively and specimens were taken, radiographed and studied by both light and scanning electron microscopy.
  
  
  RESULTS
  One rabbit died at four months postoperatively as a result of gastrointestinal problems. No other complications were seen. The SR-PLLA wire was slowly degraded. There was no disturbance of bone healing. The implants were surrounded by a fibrous tissue capsule, which also contained chronic inflammatory cells. Both SR-PLLA and steel wires provided sufficient fixation security. No differences in the healing of the sternotomies were observed between SR-PLLA and steel wire fixation.
  
  
  CONCLUSIONS
  SR-PLLA wires are biocompatible and useful for sternotomy fixation. They may be suitable for use in clinical applications.
authors.affiliation: Department of Surgery, Oulu University Hospital, Finland.
authors.forename: P A
authors.initials: PA
authors.lastname: Mäkelä
authors.forename: M
authors.initials: M
authors.lastname: Ruuskanen
authors.forename: N
authors.initials: N
authors.lastname: Ashammakhi
authors.forename: M
authors.initials: M
authors.lastname: Kallioinen
authors.forename: T
authors.initials: T
authors.lastname: Pohjonen
authors.forename: W
authors.initials: W
authors.lastname: Serlo
authors.forename: P
authors.initials: P
authors.lastname: Törmälä
authors.forename: T
authors.initials: T
authors.lastname: Waris
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001673:Biodegradation, Environmental; D001864:Bone Wires; D005549:Foreign-Body Reaction / Q000473:pathology; D011091:Polyesters; D011817:Rabbits; D012867:Skin / Q000473:pathology; D013249:Sternum / Q000601:surgery*; D014945:Wound Healing
chemical_list: D011091:Polyesters; C033616:poly(lactide)