title: Confirmation of paternal disomy in a twin molar pregnancy. A case report.
abstract: BACKGROUND
  Paternal dispermy can be the pathogenesis of complete molar pregnancy.
  
  
  METHODS
  A 23-year-old, white woman, gravida 4, para 1, was pregnant with a twin gestation by ovulation induction with metrodin. Ultrasound evaluation confirmed an intrauterine pregnancy in conjunction with what appeared to be a hydatidiform mole. The karyotype in the molar pregnancy, obtained from chorionic villus sampling, showed a pair of paternally derived inverted chromosomes 9, confirming the diagnosis of a complete mole. Uncontrollable hemorrhage with a rapid rise in the beta-human chorionic gonadotropin titer necessitated evacuation of the uterus. The patient was followed with beta-human chorionic gonadotropin titers for a year, with no evidence of recurrence.
  
  
  CONCLUSIONS
  This case illustrates paternal disomy in a complete molar pregnancy documented by a paternal chromosome 9 inversion.
authors.affiliation: Houston Perinatal Associates and Laboratories for Genetic Services, Inc., Texas 77054, USA.
authors.forename: B
authors.initials: B
authors.lastname: Kirshon
authors.forename: A
authors.initials: A
authors.lastname: Reiter
authors.forename: K
authors.initials: K
authors.lastname: Adam
authors.forename: S W
authors.initials: SW
authors.lastname: Cheung
mesh_terms: D000328:Adult; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D007446:Chromosome Inversion; D002899:Chromosomes, Human, Pair 9; D004200:Diseases in Twins; D005220:Fathers; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis / Q000235:genetics*; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014427:Twins
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D008596:Menotropins