Combined intraepithelial squamous neoplasia and atypical fibroxanthoma of the cornea and limbus.
OBJECTIVE
To investigate a case of an unusual neoplasm of the cornea and limbus.


METHODS
A 59-year-old man presented with a highly vascularized, nodular mass involving the left cornea and limbus. An excisional biopsy and, subsequently, a superficial lamellar keratectomy and multiple conjunctival biopsies were performed. At the 6-month follow-up examination, repeat conjunctival biopsies were performed.


RESULTS
Histopathologic examination of the corneal specimen showed a high-grade intraepithelial squamous neoplasia (in situ carcinoma) overlying an atypical fibroxanthoma.


CONCLUSIONS
We report the clinical and histologic appearance of a corneal/limbal neoplasm consisting of an intraepithelial squamous neoplasia and an atypical fibroxanthoma.
Engelbrecht
N E
NE
Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Ford
J G
JG
White
W L
WL
Yeatts
R P
RP
D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D003316:Corneal Diseases / Q000473:pathology* / Q000601:surgery; D005134:Eye Neoplasms / Q000473:pathology* / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery