title: Syntheses and studies of multiwarhead siderophore-5-fluorouridine conjugates.
abstract: Siderophores are microbial iron chelating agents that sequester physiologically essential iron for microbes. Conjugation of drugs to siderophores allows use of active iron transport for microbially directed drug delivery. Syntheses and biological studies are described of the first multidrug isocyanurate-based siderophore analogues separately containing one, two, and three 5-fluorouridine (5-FU) derivatives as the drug component. The results indicate that a single siderophore can be used to deliver multiple drugs to target pathogenic microorganisms.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, IN 46556-5670, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Lu
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D000935:Antifungal Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D001693:Biological Transport, Active; D002176:Candida albicans / Q000187:drug effects; D016503:Drug Delivery Systems; D015195:Drug Design; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects; D007501:Iron / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D017262:Siderophores / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry*; D014529:Uridine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D017262:Siderophores; C001943:5-fluorouridine; D007501:Iron; D014529:Uridine