On the persistence of the radioprotective effect of chlorophyllin (CHLN) in somatic cells of Drosophila.
By delaying the time of gamma irradiation of 72 h larvae, pretreated at 48 h with 5% chlorophyllin (CHLN), it was established that the overall inhibiting effect of CHLN in somatic cells of Drosophila, as measured in the wing spot test, persists for about 4 days or until the time of cessation of the proliferation of wing anlagen. In the same population of cells, some spot classes gave evidence of an inhibitory effect whereas others did not arguing against the suggestion that the radioprotective effect of CHLN is a consequence of an induced delay in development, shrinking of the potential radiation target and lowering the probability of induced events. Other observations of interest are described.
Pimentel
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Departamento de Genetica, Instituto Nacional de Investigaciones Nucleares (ININ), Edo. de Mexico, Salazar, Mexico.
Cruces
M P
MP
Zimmering
S
S
D000818:Animals; D002735:Chlorophyllides / Q000494:pharmacology*; D004330:Drosophila / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D007814:Larva / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D008297:Male; D009154:Mutation; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014921:Wings, Animal / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects
D002735:Chlorophyllides; D011837:Radiation-Protective Agents; C007020:chlorophyllin