[The protective effect of preliminary adaptation to the stress from disorders of the gas-transport function of the blood in hemorrhagic shock].
To prevent disturbances of blood gas-transport function in hemorrhagic shock, we used cross-over protective effect of adaptation to short-term immobilization stress. Adaptation of rats to stress was associated with a rise in baseline arterial blood, pH in venous blood; fall in PO2, PCO2,P50. Stress-adapted rats appeared more resistant to blood loss. Gas transport 1 hour after hemorrhage was better than in non-adapted animals demonstrated more active compensatory reactions in l low hypoxic damage to the tissues. 2.5-h survival after start of bleeding in control animals made up 35%, in the group of adapted animals--67%. Thus, adaptation to short-term immobilization stress is a non-pharmacological method to prevent hemorrhagic shock.
Arkhipenko
Iu V
IuV
Zhukova
A G
AG
Kizichenko
N V
NV
Tarakanov
I A
IA
Kozhevnikova
L M
LM
D000222:Adaptation, Physiological; D000818:Animals; D001692:Biological Transport; D002245:Carbon Dioxide / Q000097:blood*; D004195:Disease Models, Animal; D008297:Male; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012771:Shock, Hemorrhagic / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D013997:Time Factors
D002245:Carbon Dioxide; D010100:Oxygen