title: [Splenectomy in immune thrombocytopenia and other hematological diseases].
abstract: The Authors report a retrospective study of 74 splenectomies performed for hematologic diseases. The role of splenectomy has changed over recent years with increased indications for immune thrombocytopenic purpura (ITP). The aim of this study was to assess indications to surgery in relation to clinical presentation with typical hemorrhagic features or severe thrombocytopenia only; interval between onset of symptoms and splenectomy; failure of medical management and complications from steroid administration; scintigraphic studies predictive of response to splenectomy and preoperative treatment in patients with severe thrombocytopenia were also studied. The Authors reported response rates to splenectomy of 84% without mortality and only 11% of postoperative complications. These results encouraged to surgery for treatment of those patients with severe thrombocytopenia, who fail to obtain remission or develop serious complications after medical therapy. The splenectomy cured severe thrombocytopenia also in some patients with acquired immunodeficiency (HIV+). Moreover the Authors discuss the indications in patients with chronic lymphatic leukaemia and lymphoma diseases. In selected patients the splenectomy has the potential to relieve symptoms due to splenomegaly, correct cytopenias, specify hystological diagnosis and modify the disease course of malignant lymphomas. In fact splenomegaly sometimes complicated the course of malignant lymphomas because of hematologic abnormalities that are inconsistent with active chemotherapy.
authors.affiliation: Cattedra di Semeiotica Chirurgica, Università degli Studi di Brescia.
authors.forename: S
authors.initials: S
authors.lastname: Lanzi
authors.forename: G P
authors.initials: GP
authors.lastname: Lancini
authors.forename: T
authors.initials: T
authors.lastname: Piardi
authors.forename: F
authors.initials: F
authors.lastname: Biasca
authors.forename: G M
authors.initials: GM
authors.lastname: Ottaviani
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Pizzoccaro
authors.forename: A
authors.initials: A
authors.lastname: Pouchè
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D005260:Female; D006402:Hematologic Diseases / Q000601:surgery*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007153:Immunologic Deficiency Syndromes / Q000151:congenital; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007938:Leukemia / Q000601:surgery; D008223:Lymphoma / Q000601:surgery; D008228:Lymphoma, Non-Hodgkin / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D055728:Primary Myelofibrosis / Q000601:surgery; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000601:surgery* / Q000628:therapy; D012189:Retrospective Studies; D013156:Splenectomy; D013163:Splenomegaly / Q000209:etiology / Q000601:surgery
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents