title: Potentiation of the effectiveness of Lactobacillus casei in the prevention of E. coli induced diarrhea in conventional and gnotobiotic pigs.
abstract: The influence of preventive administration of Lactobacillus casei subsp. casei and maltodextrin KMS X-70 on Escherichia coli 08: K88 adhesion in the gastrointestinal tract of 11 conventional and 6 gnotobiotic piglets was investigated. The preventive administration of L. casei alone had almost no inhibitory effect on the adherence of E. coli to the jejunal mucosa of gnotobiotic and conventional piglets while the lactobacilli administered together with maltodextrin decreased the number of E. coli colonising jejunal mucosa of gnotobiotic piglets by 1 logarithm (4.95 log 10/cm2) in comparison with the control group (5.96 log 10/cm2). L. casei administered in combination with maltodextrin decreased the number of E. coli colonising the jejunum of conventional piglets by more than two and half logarithm (4.75 log 10/cm2, p < 0.05) in comparison with the control (7.42 log 10/cm2). The inhibitory effect of Lactobacillus casei and maltodextrin KMS X-70 on the adhesion of E. coli to the intestinal mucosa of conventional and gnotobiotic pigs was probably mediated by Lactobacillus--produced antibacterial substances and stimulation of immunity.
authors.affiliation: Research Institute of Experimental Veterinary Medicine, Kosice, Slovak Republic.
authors.forename: A
authors.initials: A
authors.lastname: Bomba
authors.forename: R
authors.initials: R
authors.lastname: Nemcová
authors.forename: S
authors.initials: S
authors.lastname: Gancarcíková
authors.forename: R
authors.initials: R
authors.lastname: Herich
authors.forename: R
authors.initials: R
authors.lastname: Kastel
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D003106:Colon / Q000382:microbiology; D003967:Diarrhea / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D005856:Germ-Free Life; D007082:Ileum / Q000382:microbiology; D007413:Intestinal Mucosa / Q000382:microbiology; D007583:Jejunum / Q000382:microbiology; D019344:Lactic Acid / Q000378:metabolism; D007780:Lacticaseibacillus casei / Q000276:immunology / Q000502:physiology*; D011134:Polysaccharides / Q000378:metabolism; D013552:Swine
chemical_list: D011134:Polysaccharides; D019344:Lactic Acid; C008315:maltodextrin