title: [alpha-Neurotoxins and alpha-conotoxins--nicotinic cholinoreceptor blockers].
abstract: The review is devoted to the competitive blockers of different nicotinic acetylcholine receptors, alpha-neurotoxins from snake venoms, and alpha-conotoxins from marine snails of the Conidae family. The relationship between the structure and function of these toxins is discussed. Recent data on the mechanism of alpha-neurotoxin and alpha-conotoxin interaction with the nicotinic acetylcholine receptor are presented.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. utkin@ibch.siobc.ras.ru
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Utkin
authors.forename: I E
authors.initials: IE
authors.lastname: Kasheverov
authors.forename: V I
authors.initials: VI
authors.lastname: Tsetlin
mesh_terms: D000595:Amino Acid Sequence; D020916:Conotoxins / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry / Q000494:pharmacology*; D018733:Nicotinic Antagonists / Q000737:chemistry / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid
chemical_list: D020916:Conotoxins; D009498:Neurotoxins; D018733:Nicotinic Antagonists