title: Molecular structure and functional role of vascular tight junctions.
abstract: Interendothelial tight junctions regulate paracellular permeability and maintain cell polarity. The assembly and remodeling of tight junctions are examined, focusing on the molecular interactions between tight junction components and their functional role in endothelial biology. The molecular structures of two subcellular organelles related to tight junctions, the intercalated disks in cardiomyocytes and the slit diaphragms in glomerular podocytes, are discussed.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bazzoni
authors.forename: O
authors.initials: O
authors.lastname: Martínez Estrada
authors.forename: E
authors.initials: E
authors.lastname: Dejana
mesh_terms: D002320:Cardiovascular Physiological Phenomena; D002448:Cell Adhesion; D002463:Cell Membrane Permeability / Q000502:physiology; D004727:Endothelium / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D019108:Tight Junctions / Q000502:physiology* / Q000648:ultrastructure; D014553:Urinary Tract Physiological Phenomena
chemical_list: D008565:Membrane Proteins