[Beta-3 adrenergic receptor--structure and role in obesity and metabolic disorders].
Structure and essential motifs of beta 3-adrenergic receptor (known previously as atypical beta-AR), which plays a central role in regulation of lipid metabolism have been described. Obesity results from an imbalance between caloric intake and energy expenditure. The consequence of catecholamine activation of beta 3-AR is increased mobilization of fatty acids from triglyceride stores (lipolysis) in brown and white adipose tissue as well as increased fatty acid beta-oxidation and heat-production via UCP-1 (thermogenesis) in brown adipose tissue. A pharmacokinetic effects of beta 3-agonists and putative involvement of Trp/Arg mutation in beta 3-AR gene in obesity and another metabolic disorders have been discussed.
Wiejak
J
J
Zakład Biologii Komórki, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN w Warszawie.
Wyroba
E
E
D000818:Animals; D004734:Energy Metabolism; D006801:Humans; D050356:Lipid Metabolism; D009154:Mutation; D009765:Obesity / Q000235:genetics* / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D022702:Receptors, Adrenergic, beta-3
D011943:Receptors, Adrenergic, beta; D022702:Receptors, Adrenergic, beta-3