Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones.
With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural supply of 1 from the rare sponge source.
Paterson
I
University Chemical Laboratory Lensfield Road, Cambridge CB2 1EW (UK).
Florence
GJ
Gerlach
K
Scott
JP