[Effect of delta sleep-inducing peptide on lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress].
I. p. administration of exogenous delta-sleep-inducing peptide (DSIP) decreased the amount of diene conjugates and Schiff bases in the liver and brain in rats. The xanthine oxidase activity, at that, did not change. Cold stress enhanced the xanthine oxidase activity well as the amount of diene conjugates and Schiff bases. Preliminary administration of the delta-sleep-inducing peptide to cold-exposed animals diminished the xanthine oxidase activity and lipid peroxidation in the liver and brain. Protective effects of the DSIP under stress is discussed.
Bondarenko
T I
TI
Rostov State University, Russia.
Miliutina
N P
NP
Shustanova
T A
TA
Mikhaleva
I I
II
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism; D003080:Cold Temperature; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D013312:Stress, Physiological / Q000201:enzymology / Q000378:metabolism*; D014969:Xanthine Oxidase / Q000378:metabolism*
D003701:Delta Sleep-Inducing Peptide; D014969:Xanthine Oxidase