Molecular cloning and mapping of a novel ADAM gene (ADAM29) to human chromosome 4.
Members of the ADAM family (type I integral membrane protein with a disintegrin and metalloprotease domain) have been implicated in many important biological processes involving cell-cell and cell-matrix interactions, such as fertilization and myoblast fusion. We report here the cDNA sequence of a novel human ADAM gene (ADAM29) that contains a putative fusion peptide. Northern blot analysis revealed that the mRNA of ADAM29 is highly expressed in the testis. By radiation hybrid panel mapping, the ADAM29 gene was assigned to human chromosome 4q34.2-qter.
Xu
R
R
State Key Laboratory of Genetic Engineering, Institute of Genetics, Fudan University, Shanghai, 200433, People's Republic of China.
Cai
J
J
Xu
T
T
Zhou
W
W
Ying
B
B
Deng
K
K
Zhao
S
S
Li
C
C
D051722:ADAM Proteins; D000595:Amino Acid Sequence; D015152:Blotting, Northern; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D003001:Cloning, Molecular; D019483:Disintegrins / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism; D008126:Lod Score; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis / Q000235:genetics; D008666:Metalloendopeptidases / Q000096:biosynthesis / Q000235:genetics*; D008969:Molecular Sequence Data; D009928:Organ Specificity; D020161:Physical Chromosome Mapping; D017386:Sequence Homology, Amino Acid; D013737:Testis / Q000378:metabolism
D019483:Disintegrins; D008565:Membrane Proteins; D051722:ADAM Proteins; C110998:ADAM20 protein, human; C110999:ADAM21 protein, human; C122189:ADAM29 protein, human; D008666:Metalloendopeptidases