title: Effects of frusemide on electrolyte and acid-base balance during exercise.
abstract: This study was undertaken to evaluate the effects of frusemide on the concentration of plasma electrolytes and the relationship between changes in electrolyte concentration and the simultaneous changes in acid-base balance in arterial and venous blood during intense exercise. Five exercise-conditioned Thoroughbred horses were exercised on a high-speed treadmill at a slope of 10% at speeds known to exceed VO2max. Horses participated in 3 randomised exercise trials in which they received either placebo (control), low-dose frusemide (0.5 mg/kg bwt), or high-dose frusemide (1.0 mg/kg) 4 h prior to exercise. Arterial and mixed venous blood samples were drawn before, during and after intense exercise. Packed cell volume (PCV), plasma protein, plasma electrolyte, plasma lactate concentrations and acid-base balance were determined. Frusemide at both dosages induced a significant metabolic alkalosis associated with a decrease in plasma çhloride[ in both arterial and mixed venous blood. There was a highly significant correlation between the strong ion difference (SID) and bicarbonate[ in all blood samples. The effects of frusemide on electrolyte concentration and acid-base balance were largely due to changes in SID.
authors.affiliation: Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Carlson
authors.forename: J H
authors.initials: JH
authors.lastname: Jones
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D005080:Exercise Test / Q000662:veterinary; D005665:Furosemide / Q000494:pharmacology*; D006736:Horses / Q000502:physiology*; D008954:Models, Biological; D010805:Physical Conditioning, Animal / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D004232:Diuretics; D005665:Furosemide