title: Continuous flow infrared matrix-assisted laser desorption/ionization with a solvent matrix
abstract: Continuous flow matrix-assisted laser desorption/ionization (MALDI) was demonstrated with infrared laser desorption and an ethanol matrix. A capillary was used to deliver an analyte solution dissolved in ethanol to a metal frit embedded in a sample stage. Typical flow rates were 1.7&mgr;L/min. An optical parametric oscillator tuned to 2.8&mgr;m was used for desorption and ionization, and mass analysis was achieved with a 1 m linear time-of-flight mass spectrometer. Flow injection studies were performed with low picomolar quantities of insulin and myoglobin in solutions containing 0.1 to 1.0% glycerol in ethanol. Copyright 2000 John Wiley & Sons, Ltd.
authors.affiliation: Emory University, Department of Chemistry, 1515 Pierce Drive, Atlanta, GA 30322, USA.
authors.initials: SJ
authors.lastname: Lawson
authors.initials: KK
authors.lastname: Murray