title: Molecular interactions of neural chondroitin sulfate proteoglycans in the brain development.
abstract: Aggrecan family proteoglycans, phosphacan/RPTPzeta/beta, and neuroglycan C (NGC) are the major classes of chondroitin sulfate proteoglycan in the developing mammalian brain. A multidomain is a common structural feature of these proteoglycans which can interact with various molecules including growth factors, cell adhesion molecules, and extracellular matrix molecules. Individual proteoglycans are distributed in the developing brain in a distinct temporal and spatial pattern, suggesting that they are involved in distinct phases of the brain development through multiple molecular interactions. This review mainly summarizes recent studies on the involvement of these three classes of proteoglycan in cell-cell and cell-substratum interactions during the brain development. Their expressions and proposed functional roles in injured brains are also mentioned. In addition, this review briefly covers potential functions of other neural chondroitin sulfate proteoglycans such as decorin, testican, NG2 proteoglycan, and amyloid precursor protein (APP) in developing and injured brains.
authors.affiliation: Department of Perinatology and Neuroglycoscience, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Aichi, 480-0392, Japan. oohira@inst-hsc.pref.aichi.jp
authors.forename: A
authors.initials: A
authors.lastname: Oohira
authors.forename: F
authors.initials: F
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Tokita
authors.forename: S
authors.initials: S
authors.lastname: Yamauchi
authors.forename: S
authors.initials: S
authors.lastname: Aono
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009420:Nervous System / Q000254:growth & development / Q000378:metabolism*; D011485:Protein Binding; D011509:Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; D011509:Proteoglycans