title: Genome-wide screen for atopy susceptibility alleles in the Hutterites.
abstract: A genome-wide screen for loci influencing positive skin prick tests (SPT) to airborne allergens was conducted in the Hutterites, a founder population of European ancestry. Positive SPT to 14 standardized allergens was measured in 370 subjects in our primary sample and 324 subjects in a replication sample. Evidence for linkage to positive SPT was assessed using the transmission disequilibrium test (TDT) with 337 autosomal markers (average spacing 9.13 cM, SD = 7.8 cM). Three loci showed the strongest overall evidence of linkage to atopy, with at least one allele-specific and a locus-specific p< 1 x 10(-4). This study provides evidence for at least three atopy-susceptibility loci in the Hutterites on chromosomes 1, 6 and 16.
authors.affiliation: Department of Human Genetics, The University of Chicago, IL 60636, USA.
authors.forename: C
authors.initials: C
authors.lastname: Ober
authors.forename: A
authors.initials: A
authors.lastname: Tsalenko
authors.forename: S
authors.initials: S
authors.lastname: Willadsen
authors.forename: D
authors.initials: D
authors.lastname: Newman
authors.forename: R
authors.initials: R
authors.lastname: Daniel
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.forename: J
authors.initials: J
authors.lastname: Andal
authors.forename: D
authors.initials: D
authors.lastname: Hoki
authors.forename: D
authors.initials: D
authors.lastname: Schneider
authors.forename: K
authors.initials: K
authors.lastname: True
authors.forename: C
authors.initials: C
authors.lastname: Schou
authors.forename: R
authors.initials: R
authors.lastname: Parry
authors.forename: N
authors.initials: N
authors.lastname: Cox
mesh_terms: D000328:Adult; D000483:Alleles; D002874:Chromosome Mapping; D005006:Ethnicity; D005060:Europe; D005260:Female; D018703:Founder Effect; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D044465:White People