Lipoproteins, lipidic peroxidation and total antioxidant capacity in serum of aged subjects suffering from hyperglycemia.
Quantitative alterations of serum lipoproteins were studied as well as lipidic peroxidation level and total antioxidant capacity in the serum of 265 subjects ranging in age between 60-70 years, out of which 97 showed levels of glycemia higher than normal. Increase of LDL and VLDL was found in 74.6% respectively 67% of the old-aged subjects researched, without also finding significant differences between sexes. Frequent association between the two metabolic disorders is seen without there being a statistical correlation between degree of dyslipidemia and blood glucose level. The level of lipid peroxidation, determined by serum malondialdehyde (MDA) concentration, is higher in subjects with dyslipidemia where glycemia level exceeds 200 mg%. Total antioxidant defence in old aged hyperglycemic patients decreases by 18% as against the value seen in the controls. The normally glycemic patients show a decrease in this activity by only 12%. Significant frequency of dyslipidemia in the old aged studied is associated with hyperglycemia and can be accounted for beyond biologic mechanisms characteristic of aging, through a deficient diet. Association of dyslipidemia with hyperglycemia, the high level of lipidic peroxides and the diminution of body capacity of annihilating them, actually represents an increase in risk factors for onset of vascular attacks.
Serban
M G
MG
C. Davila University of Medicine and Pharmacy, Department of Physiopathology, Bucharest, Romania.
Negru
T
T
D000328:Adult; D000368:Aged; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000032:analysis*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D006949:Hyperlipidemias / Q000097:blood; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors
D000975:Antioxidants; D008074:Lipoproteins