[Two cases of sporadic juvenile Parkinson's disease caused by homozygous deletion of Parkin gene].
Parkin gene, which is one of the causes of familial Parkinson's disease, was cloned in 1998, and it was found that mutations of this gene induces familial Parkinson's disease of autosomal recessive form (AR-JP). Clinical studies have revealed that almost cases of AR-JP are consanguineous or hereditary. However, AR-JP may also be caused by marriage between two carriers. We therefore investigated the existence of a homozygous deletion in the parkin gene in 10 patients with juvenile Parkinson's disease with the onset of age younger than 40 years without consanguinity or heredity. A large delection of the gene was found in 2 of the 10 patients with sporadic Parkinson's disease, and both of these deletion were exon 4. The present study clearly suggests that juvenile Parkinson's disease in Japan may be caused by abnormalities in parkin gene regardless of family history or consanguinity.
Ujike
H
H
Department of Neuropsychiatry, Okayama University Medical School, Japan.
Yamamoto
M
M
Yamaguchi
K
K
Kanzaki
A
A
Takagi
M
M
Kuroda
S
S
D017668:Age of Onset; D005260:Female; D017353:Gene Deletion; D006720:Homozygote; D006801:Humans; D008025:Ligases; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D011506:Proteins / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases
D011506:Proteins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases