Plasma catecholamine responses during laparoscopic gynecologic surgery with CO(2) insufflation.
OBJECTIVE
To compare adrenergic-sympathetic responses during pelvic laparoscopic surgery with CO(2) insufflation with those during laparotomy. DESIGN. Prospective study (Canadian Task Force classification II-1).


METHODS
Tertiary care university hospital.


METHODS
Twenty-one infertile women with a clinical diagnosis of endometriosis.


METHODS
Plasma norepinephrine (NE) and epinephrine (E) levels were measured in patients undergoing laparoscopic or open pelvic surgery.


RESULTS
During laparoscopic surgery, increases in NE and E levels were correlated with arterial tension of CO(2) (PaCO(2)) and were greater in patients with a larger increase in PaCO(2) than in those undergoing laparotomy. Hemodynamic changes were also more evident during laparoscopic surgery, with larger PaCO(2) increases.


CONCLUSIONS
The PaCO(2) increases due to CO(2) insufflation are associated with adrenergic-sympathetic activation and hemodynamic changes during laparoscopic pelvic surgery.
Ishizuka
B
B
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, Japan 216-8155.
Kudo
Y
Y
Amemiya
A
A
Tanii
M
M
Aoki
T
T
D000328:Adult; D002245:Carbon Dioxide; D004715:Endometriosis / Q000601:surgery*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007327:Insufflation; D010535:Laparoscopy; D007813:Laparotomy; D009638:Norepinephrine / Q000097:blood*; D011446:Prospective Studies
D002245:Carbon Dioxide; D009638:Norepinephrine; D004837:Epinephrine