title: Scaffolding and protein interactions in MAP kinase modules.
abstract: MAP kinases are a family of protein kinases that are ubiquitously expressed and play roles in most signal transduction pathways. They are activated within protein kinase cascades consisting of at least three kinases acting in series. In many, if not all cases, the three-kinase cascade, conveniently referred to as a MAP kinase module, is organized on scaffolds with a variety of forms and functions. This review discusses similarities and differences in scaffolding proteins and mechanisms in yeast, flies, worms and mammals.
authors.affiliation: Department of Pharmacology, Southwestern Medical Center, Dallas, TX 75235-9041, USA.
authors.forename: M
authors.initials: M
authors.lastname: Karandikar
authors.forename: M H
authors.initials: MH
authors.lastname: Cobb
mesh_terms: D000818:Animals; D020930:MAP Kinase Kinase Kinases / Q000737:chemistry / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000737:chemistry / Q000502:physiology*; D013329:Structure-Activity Relationship
chemical_list: D020928:Mitogen-Activated Protein Kinases; D020930:MAP Kinase Kinase Kinases