title: [Modification of mouse resistance to A/Aichi/2/68 influenza virus by a glucocorticoid immunosuppressant kenalog].
abstract: Changes in the virulence of influenza virus A/Aichi/2/68 LD50 were studied in albino mice with immunosuppression induced by long-acting glucocorticoid kenalog (Kn). In high doses (5 and 10 micrograms/g) Kn induced a decrease in the adrenal, thymic, and splenic weight, which is typical of steroid immunosuppression. The susceptibility of mice preinjected with Kn to the virus increased more than ten-fold, judging by a decrease in LD50. The detected shifts may be due to disorders in lung tissue resistance and reactivity of alveolar macrophages and neutrophils observed previously in induced glucocorticism.
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: O G
authors.initials: OG
authors.lastname: P'iankova
authors.forename: L G
authors.initials: LG
authors.lastname: Bulychev
authors.forename: V A
authors.initials: VA
authors.lastname: Petrishchenko
authors.forename: A V
authors.initials: AV
authors.lastname: Shishkin
authors.forename: G A
authors.initials: GA
authors.lastname: Buriak
authors.forename: E F
authors.initials: EF
authors.lastname: Bocharov
authors.forename: V A
authors.initials: VA
authors.lastname: Zhukov
mesh_terms: D000818:Animals; D004198:Disease Susceptibility / Q000276:immunology*; D005938:Glucocorticoids / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide