title: Malignant melanoma occurring within a previously irradiated area.
abstract: The commonest radiation-induced neoplasms are sarcomas. Ionizing radiation is not usually associated with the development of malignant melanoma. We report two patients with malignant melanoma occurring within a previously irradiated area. There is evidence to support radiation in the pathogenesis of melanoma but the family histories, especially in one patient, suggest that genetic mutations may also have played a role, particularly in relation to the short latent period.
authors.affiliation: The Cancer Centre, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: A
authors.initials: A
authors.lastname: Stevens
authors.forename: D
authors.initials: D
authors.lastname: Spooner
mesh_terms: D000328:Adult; D001132:Arm; D001943:Breast Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007866:Leg; D007890:Leiomyosarcoma / Q000150:complications / Q000532:radiotherapy / Q000601:surgery; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000209:etiology*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000000981:diagnostic imaging / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology*; D012983:Soft Tissue Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors