Posterior chamber silicone intraocular lens for the correction of myopia: an experimental study in rabbits.
OBJECTIVE
To establish whether ocular lesions arise after implantation of posterior chamber silicone intraocular lenses (IOL) for the correction of high myopia.


METHODS
Twenty-three posterior chamber silicone IOL were implanted in 23 eyes of the same number of pigmented rabbits. After different follow-up time (from one week to one year) the eyes were enucleated and processed for histopathological study after determining the protein concentration in the aqueous humor. The IOL were removed for staining and examination, and adhered cells were counted. Ten eyes analogous to those operated upon were used as controls.


RESULTS
Intense inflammation was observed in the early postoperative period in all cases. Protein concentration in the aqueous humor was initially high and decreased over time, though without reaching normal values at one year. Mono- and multinucleated cells were seen adhering to the IOL, though they decreased in number over time and were practically absent after one year. Friction between the posterior surface of the iris and the IOL had no clinical repercussions. The only pigment accumulations were in the iris and in the peritrabecular zone. There were no significant differences in the accumulation of granules in relation to IOL diameter or power. Excluding three cataracts morphologically similar to traumatic cataracts, five lens opacifications were observed: two were anterior subcapsular cataracts, and the other three were only precapsular deposits. The IOL had no synechiae to the ocular tissues.


CONCLUSIONS
Opacification of the lens is the main concern with implanted posterior chamber silicone IOL. Larger series of eyes must be analysed to establish the true incidence and reversibility of these opacities.
Menezo
J L
JL
Department of Ophthalmology, La Fé University Hospital, Valencia University Medical School, Spain.
Salinas
E
E
Aviño
J A
JA
Navea
A
A
Cisneros
A
A
D000818:Animals; D002386:Cataract / Q000209:etiology*; D002465:Cell Movement / Q000502:physiology; D005136:Eye Proteins / Q000378:metabolism; D007249:Inflammation / Q000473:pathology; D007910:Lenses, Intraocular / Q000009:adverse effects*; D009216:Myopia / Q000628:therapy*; D010860:Pigments, Biological / Q000378:metabolism; D011817:Rabbits; D012828:Silicones / Q000009:adverse effects*; D013997:Time Factors
D005136:Eye Proteins; D010860:Pigments, Biological; D012828:Silicones