Cloning and expression of the murine sws/NTE gene.
The Drosophila neurodegeneration gene swiss-cheese encodes a neuronal protein apparently involved in glia-neuron interaction and is homologous to human NTE, the molecular target of organophosphate-induced neuropathy. The isolated Msws/NTE gene is 96% identical to NTE. During development the Msws transcript is expressed in the embryonic respiratory system, different epithelial structures and strongly in the spinal ganglia. Postnatally, Msws mRNA is expressed in all brain areas, with an increasingly restrictive pattern. In adult mice expression is most prominent in Purkinje cells, granule cells and pyramidal neurons of the hippocampus and some large neurons in the medulla oblongata, nucleus dentatus and pons.
Moser
M
M
Lehrstuhl für Entwicklungsbiologie, Universitätsstrasse 31, Universität Regensburg, 93053, Regensburg, Germany.
Stempfl
T
T
Li
Y
Y
Glynn
P
P
Büttner
R
R
Kretzschmar
D
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D029721:Drosophila Proteins; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*
D018076:DNA, Complementary; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C108350:SWS protein, Drosophila; D002265:Carboxylic Ester Hydrolases; C021859:neurotoxic esterase