title: 1999 ARRS Executive Council Award. Creation of saccular aneurysms in the rabbit: a model suitable for testing endovascular devices. American Roentgen Ray Society.
abstract: OBJECTIVE
  This study developed an animal model of intracranial aneurysms suitable for evaluating emerging endovascular devices for aneurysmal therapy. We characterized the short-, medium-, and long-term attributes of this endovascular technique for saccular aneurysmal creation in the rabbit.
  
  
  METHODS
  The right common carotid artery was surgically exposed in nine New Zealand white rabbits. Using endovascular techniques, we occluded the origin of the right common carotid artery with a pliable balloon. Elastase was incubated endoluminally in the proximal common carotid artery above the balloon. The common carotid artery was ligated distally. Animals were studied angiographically and sacrificed at 2 weeks (n = 3), 10 weeks (n = 3), and 24 weeks (n = 3) after aneurysm creation. Histology was obtained.
  
  
  RESULTS
  Saccular aneurysms formed in eight of the nine rabbits. The aneurysm projected from the apex of an approximately 90 degree curve of the parent vessel, the brachiocephalic artery. Mean aneurysm diameter was 4.5 mm (SD, 1.2 mm), and mean height was 7.5 mm (SD, 1.6 mm). All samples showed thinned elastic lamina and no evidence of inflammation. In four of eight aneurysms, unorganized thrombus was present in the dome of the aneurysm.
  
  
  CONCLUSIONS
  Arterial aneurysms with intact endothelium and deficient elastic lamina were reliably created in an area of high shear stress in New Zealand white rabbits. Three of these aneurysms remained patent for at least 6 months. We found a simple procedure that can be readily applied to the testing of new endovascular devices for a reliable creation of aneurysms in rabbits.
authors.affiliation: Department of Radiology, University of Virginia Health Services, Charlottesville 22908, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Altes
authors.forename: H J
authors.initials: HJ
authors.lastname: Cloft
authors.forename: J G
authors.initials: JG
authors.lastname: Short
authors.forename: A
authors.initials: A
authors.lastname: DeGast
authors.forename: H M
authors.initials: HM
authors.lastname: Do
authors.forename: G A
authors.initials: GA
authors.lastname: Helm
authors.forename: D F
authors.initials: DF
authors.lastname: Kallmes
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D011817:Rabbits; D011859:Radiography; D013997:Time Factors