Phenanthrenequinone antiretroviral agents.
Compounds 3 and 5 are the first phenanthrenequinones to exhibit significant virucidal activity against the retrovirus equine infectious anemia virus. They differ from hypericin in that their virucidal activity is not light dependent.
Kraus
G A
GA
Department of Chemistry, Iowa State University, Ames 50011, USA.
Melekhov
A
A
Carpenter
S
S
Wannemuhler
Y
Y
Petrich
J
J
D000818:Animals; D000873:Anthracenes; D000998:Antiviral Agents / Q000494:pharmacology*; D006736:Horses; D004860:Infectious Anemia Virus, Equine / Q000187:drug effects*; D010569:Perylene / Q000031:analogs & derivatives / Q000494:pharmacology; D010616:Phenanthrenes / Q000494:pharmacology*; D010777:Photochemistry; D013329:Structure-Activity Relationship
D000873:Anthracenes; D000998:Antiviral Agents; D010616:Phenanthrenes; C105959:1,4-phenanthrenequinone; D010569:Perylene; C004965:hypericin