title: Hyalodendrosides A and B, antifungal triterpenoid glycosides from a lignicolous hyphomycete, Hyalodendron species.
abstract: Two antifungal triterpenoid glycosides, hyalodendrosides A and B (1 and 2), were isolated from a solid matrix fermentation of a lignicolous hyphomycete, Hyalodendron sp. Their structures were determined based upon extensive examination of spectral parameters, particularly NMR and MS data. Both compounds have beta-linked glucose moieties. Compounds 1 and 2 show weak to moderate antifungal activity against some clinically relevant fungi.
authors.affiliation: Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. gerald_bills@merck.com
authors.forename: G
authors.initials: G
authors.lastname: Bills
authors.forename: A
authors.initials: A
authors.lastname: Dombrowski
authors.forename: S A
authors.initials: SA
authors.lastname: Morris
authors.forename: O
authors.initials: O
authors.lastname: Hensens
authors.forename: J M
authors.initials: JM
authors.lastname: Liesch
authors.forename: D L
authors.initials: DL
authors.lastname: Zink
authors.forename: J
authors.initials: J
authors.lastname: Onishi
authors.forename: M S
authors.initials: MS
authors.lastname: Meinz
authors.forename: M
authors.initials: M
authors.lastname: Rosenbach
authors.forename: J R
authors.initials: JR
authors.lastname: Thompson
authors.forename: R E
authors.initials: RE
authors.lastname: Schwartz
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes
chemical_list: D000935:Antifungal Agents; D012503:Saponins; D014315:Triterpenes; C404713:hyalodendroside A; C404714:hyalodendroside B