[The anxiolytic effect of ondansetron and its capacity to eliminate the benzodiazepine abstinence syndrome in rats].
Ondansetron (GR38032F, zofran)--a specific blocker of 5-HT3-receptors in a dose range of 0.05 to 0. mg/kg causes an anxiolytic effect in experiments on mice and rats on a model of elevated plus maze. The drug does not produce a sedative and myorelaxant effect. A 0.05 mg/kg dose of ondansetron reduces the level of anxiety and convulsive manifestations which are induced by discontinuation of long-term diazepam administration. The results of the study bear evidence of selectivity of the anxiolytic effect of ondansetron in intact animals and its effectiveness in rats with diazepam abstinence.
Garibova
T L
TL
Laboratory of Psychopharmacology, Institute of Pharmacology, Moscow, Russia.
Voronina
T A
TA
Kraĭneva
V A
VA
Val'dman
E A
EA
D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D003220:Conflict, Psychological; D003292:Convulsants; D003975:Diazepam / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D017294:Ondansetron / Q000494:pharmacology / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D003292:Convulsants; D017294:Ondansetron; D003975:Diazepam; D010433:Pentylenetetrazole