Activation and cross-reactivity pattern of a new allergen in adhesive plaster.
N,N'-disalicylidene-1,2-diaminopropane is a copper inhibitor present in some adhesive plasters, rubber products and gasoline. Upon contact with water it is hydrolyzed to salicylaldehyde and 1,2-diaminopropane. All patients in this study showed positive patch-test reactions to N,N'-disalicylidene-1,2-diaminopropane, and also to 1,2-diaminopropane and ethylenediamine. None reacted to salicylaldehyde. Patch testing with different N,N'-disalicylidene-derivatives showed localization of the amino groups in positions 1 and 2 to be a prerequisite of cross-reactivity to 1,2-diaminopropane and ethylenediamine. An extraction procedure and a high-performance liquid chromatography (HPLC) method for the analysis of adhesive plasters is described. Studies of the hydrolysis of the copper inhibitor at physiological pH showed rapid formation of 1,2-diaminopropane under biomimetic conditions.
Bergendorff
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O
Department of Dermatology, Lund University, University Hospital, Sweden.
Hansson
C
C
D000269:Adhesives / Q000009:adverse effects* / Q000737:chemistry; D000485:Allergens / Q000276:immunology; D001458:Bandages; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003429:Cross Reactions; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D003959:Diamines / Q000009:adverse effects / Q000032:analysis; D005029:Ethylenediamines / Q000009:adverse effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010328:Patch Tests
D000269:Adhesives; D000485:Allergens; D003959:Diamines; D005029:Ethylenediamines; C013973:disalicylidene propandiamine; C031234:ethylenediamine; C070006:1,2-diaminopropane