Effects of leukotrienes and prostaglandins on cochlear blood flow in the chinchilla.
Prostaglandins (PGs) such as PGE2 and PGI2 are vasodilators, and leukotrienes (LTs) such as LTB4 and LTC4 are vasoconstrictors. Our previous studies have shown that salicylate ototoxicity is associated with decreased levels of PGs and increased levels of LTs. We hypothesized that vasodilating PGs increase cochlear blood flow and vasoconstricting LTs decrease cochlear blood flow. PGE2, Iloprost (a PGI2 analog), LTB4, and LTC4 were applied to the round window membranes of chinchillas and cochlear blood flow was measured with a laser Doppler flowmeter. PGE2 increased cochlear blood flow, while LTC4 decreased cochlear blood flow. This findings show that vasodilating PGs may have therapeutic implications for sensorineural hearing loss and/or vertigo by increasing cochlear blood flow. Vasoconstricting LTs may cause hearing loss by decreasing cochlear blood flow.
Rhee
C K
CK
Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Chungnam-Do, Korea.
Park
Y S
YS
Jung
T T
TT
Park
C I
CI
D000818:Animals; D002682:Chinchilla; D003051:Cochlea / Q000098:blood supply / Q000187:drug effects*; D015232:Dinoprostone / Q000494:pharmacology* / Q000627:therapeutic use; D006311:Hearing Disorders / Q000139:chemically induced; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy; D016285:Iloprost / Q000494:pharmacology* / Q000627:therapeutic use; D017078:Laser-Doppler Flowmetry; D007975:Leukotriene B4 / Q000009:adverse effects / Q000494:pharmacology*; D017997:Leukotriene C4 / Q000009:adverse effects / Q000494:pharmacology*; D011897:Random Allocation; D012039:Regional Blood Flow / Q000187:drug effects; D012405:Round Window, Ear / Q000098:blood supply / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use; D014717:Vertigo / Q000188:drug therapy
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D007975:Leukotriene B4; D017997:Leukotriene C4; D016285:Iloprost; D015232:Dinoprostone