[alpha-Neurotoxins and alpha-conotoxins--nicotinic cholinoreceptor blockers].
The review is devoted to the competitive blockers of different nicotinic acetylcholine receptors, alpha-neurotoxins from snake venoms, and alpha-conotoxins from marine snails of the Conidae family. The relationship between the structure and function of these toxins is discussed. Recent data on the mechanism of alpha-neurotoxin and alpha-conotoxin interaction with the nicotinic acetylcholine receptor are presented.
Utkin
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IuN
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. utkin@ibch.siobc.ras.ru
Kasheverov
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IE
Tsetlin
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VI
D000595:Amino Acid Sequence; D020916:Conotoxins / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry / Q000494:pharmacology*; D018733:Nicotinic Antagonists / Q000737:chemistry / Q000494:pharmacology*; D017386:Sequence Homology, Amino Acid
D020916:Conotoxins; D009498:Neurotoxins; D018733:Nicotinic Antagonists