Vitamin D receptor gene polymorphisms and osteoarthritis of the hand, hip, and knee: acase-control study in Japan.
OBJECTIVE
To investigate the association between vitamin D receptor (VDR) gene polymorphisms andJapanese female patients with osteoarthritis (OA) of the hand, hip, and knee.


METHODS
BsmI,ApaI, andTaqI restriction fragment length polymorphisms (RFLPs) of the VDR gene were analysed in 270Japanese female patients with radiographic OA of the hand, hip, tibiofemoral (TF) joint, andpatellofemoral (PF) joint, as well as in female controls.


RESULTS
There was no significant association between the VDR gene RFLPs and OA of the hand, hip, TFjoint, PF joint, or polyarticular involvement. The previously detected preventive genotype of the VDRgene was uncommon in our test population.


CONCLUSIONS
The relative importance of VDR gene polymorphism in the development of OA may vary betweenethnic groups.
Huang
J
J
Department of Orthopaedic Surgery, Shiga University of Medical Science, Seta, Otsu,520-2192, Japan.
Ushiyama
T
T
Inoue
K
K
Kawasaki
T
T
Hukuda
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D006225:Hand; D006621:Hip Joint; D006801:Humans; D007564:Japan; D007719:Knee Joint; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012016:Reference Values
D018167:Receptors, Calcitriol