title: Antibacterial and antiandrogen flavonoids from Sophora flavescens.
abstract: Sixteen flavanones, three flavanonols, and four pterocarpans were isolated from the MeOH extract of the roots of Sophora flavescens. Twelve of these were new compounds, including eight prenylflavanones (1-8), one prenylflavanonol (9) and three novel pterocarpane derivatives (10-12). Their structures were elucidated using NMR and mass spectral methods. Some of these compounds have irregular C10 prenyl moieties at C-8 of the flavanone skeleton. These compounds exhibited significant antibacterial activities against the Gram-positive bacteria Staphylococcus aureus, Bacillus subtilis, S. epidermidis, and Propionibacterium acnes. They also exhibited antiandrogen activities.
authors.affiliation: School of Bioresources, Hiroshima Prefectural University, Japan. kuroyang@bio.hiroshima-pu.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Kuroyanagi
authors.forename: T
authors.initials: T
authors.lastname: Arakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Hirayama
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000726:Androgen Antagonists / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D007887:Fabaceae / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
chemical_list: D000726:Androgen Antagonists; D000900:Anti-Bacterial Agents; D005419:Flavonoids; D010936:Plant Extracts