title: Pars plana vitrectomy, endolaser coagulation of the retina and the ciliary body combined with silicone oil endotamponade in the treatment of uncontrolled neovascular glaucoma.
abstract: OBJECTIVE
  Neovascular glaucoma develops on a background of ischemic ocular pathologies, such as diabetic eye diseases or central retinal vein occlusion. Development of neovascular membranes in the chamber angle leads to elevated intraocular pressure (IOP). Since cyclodestructive therapy or drainage surgery often fails, we have examined intense antiproliferative surgery as a treatment for advanced neovascular glaucoma.
  
  
  METHODS
  Thirty-two patients with uncontrolled neovascular glaucoma (mean IOP 45.5 mmHg) subsequent to central retinal vein occlusion or advanced diabetic retinopathy underwent antiproliferative surgery, which comprised pars plana vitrectomy, panretinal laser treatment and direct laser coagulation of the ciliary processes, followed by silicone oil tamponade. Patients were followed up for a minimum of 1 year and as long as 3 years.
  
  
  RESULTS
  One week following surgery the IOP was normal, ranging from 8 to 21 mmHg, in 52% of eyes (15/29). After 3 months the IOP was normal in 50% (16/32); after 6 months, in 59% (16/27); and after 1 year, in 72% (18/25). Of the 10 eyes that lost all sight after the surgery, 7 eyes had a history of central retinal vein occlusion. Hypotony was observed in 6% of the eyes (2/32) 3 months after surgery; after 6 months hypotony was present in 15% (4/27), and after 1 year hypotony was present in 12% (3/25).
  
  
  CONCLUSIONS
  The theoretical premise of our surgical intervention (antiproliferative surgery) is that laser treatment interrupts the self-enhancing pathway of retinal ischemia, release of proliferative factors and increase in intraocular pressure. The silicone oil endotamponade prevents postoperative complications and supports the rapid regression of rubeosis iridis by separating the anterior from the posterior segment.
authors.affiliation: Department of Vitreoretinal Surgery, University of Cologne, Germany. Ulrich.BartzSchmidt@uni-koeln.de
authors.forename: K U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.forename: G
authors.initials: G
authors.lastname: Thumann
authors.forename: A
authors.initials: A
authors.lastname: Psichias
authors.forename: G K
authors.initials: GK
authors.lastname: Krieglstein
authors.forename: K
authors.initials: K
authors.lastname: Heimann
mesh_terms: D000368:Aged; D000867:Anterior Chamber; D002924:Ciliary Body / Q000601:surgery*; D005260:Female; D015355:Glaucoma, Neovascular / Q000601:surgery*; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000601:surgery*; D012189:Retrospective Studies; D012827:Silicone Oils / Q000008:administration & dosage*; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy / Q000379:methods*; D018630:Vitreoretinopathy, Proliferative / Q000517:prevention & control
chemical_list: D012827:Silicone Oils