Adhesion molecule expression and phenotype of glial cells in the olfactory tract.
These data illustrate that OBECs have a highly plastic nature in keeping with their need to respond rapidly to changing environmental cues. This relates to their required function in supporting axonal extension throughout life. Future studies using antibodies to PSA-NCAM and L-NGFr together with FACS sorting to purify the two types of OBEC should give us a clearer understanding of the lineage relationship of the two phenotypes. With purified populations of the astrocyte-like and Schwann cell-like OBEC we should be able to determine if these cells have different functions in vivo, using several approaches namely: i) identifying the growth factors that regulate their growth and differentiation, ii) measuring the ability of the purified cells to remyelinate the experimentally-created CNS lesions and iii) carry out more detailed cellular and molecular comparisons of the two phenotypes.
Barnett
S C
SC
Department of Neurology, University of Glasgow.
Franceschini
I A
IA
D000818:Animals; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000502:physiology*; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology*; D009833:Olfactory Pathways / Q000166:cytology / Q000502:physiology*; D010641:Phenotype; D017475:Receptors, Nerve Growth Factor / Q000502:physiology*
D019006:Neural Cell Adhesion Molecules; D017475:Receptors, Nerve Growth Factor