title: Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoter.
abstract: Our earlier studies have shown that the flavonoid hesperidin inhibits tumor promotion in a two stage skin tumorigenesis protocol in CD-1 mice. In this study hesperidin's significant protection (p < 0.0001) against 12-0-tetradecanoylphorbol-13-acetate (TPA) induced edema in CD-1 mouse ear will be presented. Hesperidin also afforded significant protection against TPA induced hyperplasia in the dorsal skin through multiple application prior to TPA. Protection by hesperidin was 93% of the epidermal thickness and 100% of the vertical cell layers. The data also indicate the protective effect of hesperidin against TPA caused infiltration of neutrophils by 73%. These results suggest that hesperidin may possess potential as chemopreventive agent against tumor promoter induced inflammation and hyperplasia.
authors.affiliation: Istanbul University, Department of Molecular Medicine, Capa, Istanbul, Turkey. Koyuncuh@doruk.com.tr
authors.forename: H
authors.initials: H
authors.lastname: Koyuncu
authors.forename: B
authors.initials: B
authors.lastname: Berkarda
authors.forename: F
authors.initials: F
authors.lastname: Baykut
authors.forename: G
authors.initials: G
authors.lastname: Soybir
authors.forename: C
authors.initials: C
authors.lastname: Alatli
authors.forename: H
authors.initials: H
authors.lastname: Gül
authors.forename: M
authors.initials: M
authors.lastname: Altun
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006569:Hesperidin / Q000494:pharmacology*; D051379:Mice; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D002273:Carcinogens; D006569:Hesperidin