title: Leukoencephalopathy in multiple myeloma: two case reports.
abstract: BACKGROUND
  No case of leukoencephalopathy has been reported associated with multiple myeloma.
  
  
  METHODS
  We report on two patients with a very rare association of leukoencephalopathy and multiple myeloma revealed by cognitive impairment.
  
  
  RESULTS
  Chemotherapy has improved neurological and biological signs. Radiological abnormalities have been stabilized.
  
  
  CONCLUSIONS
  The authors suggest that leukoencephalopathy is probably a direct cerebral expression of malignant gammopathy.
authors.affiliation: Service de Neurologie, Hôpital Pasteur, Nice, France.
authors.forename: C
authors.initials: C
authors.lastname: Lebrun
authors.forename: S
authors.initials: S
authors.lastname: Chanalet
authors.forename: M
authors.initials: M
authors.lastname: Frenay
authors.forename: M
authors.initials: M
authors.lastname: Chatel
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D011115:Polyneuropathies / Q000188:drug therapy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan; D011241:Prednisone