Resistance of extraocular motoneuron terminals to effects of amyotrophic lateral sclerosis sera.
In sporadic ALS (s-ALS), axon terminals contain increased intracellular calcium. Passively transferred sera from patients with s-ALS increase intracellular calcium in spinal motoneuron terminals in vivo and enhance spontaneous transmitter release, a calcium-dependent process. In this study, passive transfer of s-ALS sera increased spontaneous release from spinal but not extraocular motoneuron terminals, suggesting that the resistance to physiologic abnormalities induced by s-ALS sera in mice parallels the resistance of extraocular motoneurons to dysfunction and degeneration in ALS.
Mosier
D R
DR
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA. dmosier@bcm.tmc.edu
Siklós
L
L
Appel
S H
SH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D000818:Animals; D004594:Electrophysiology; D005260:Female; D006614:Hindlimb; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009045:Motor Endplate / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation; D009801:Oculomotor Muscles / Q000294:innervation*; D017729:Presynaptic Terminals / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology