Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment? A ten-year experience [correction of experiment] must liberate them.
We detected in 1989, with the inhibitor test of proviral insertion into c-erb B erythroblastosis, two retrovirus integrase inhibitors: hydroxy-methyl-ellipticine and acriflavine. They have been used for ten years in AIDS patients with high efficacy and no toxicity. Since vitamin B12 and cobalt, which it contains, have been detected as HIV1-integrase inhibitors by an in-vitro test, we have also used vitamin B12 (combined with folic acid), whose clinical action has been remarkable. Ten or so other compounds have been detected by such in-vitro tests, among which there are many compounds (such as flavones) which are used in many conditions and are not toxic.
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D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000167:Acriflavine / Q000494:pharmacology / Q000627:therapeutic use*; D003035:Cobalt / Q000494:pharmacology; D004611:Ellipticines / Q000494:pharmacology / Q000627:therapeutic use*; D019427:HIV Integrase / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D014805:Vitamin B 12 / Q000494:pharmacology / Q000627:therapeutic use
D004611:Ellipticines; D019428:HIV Integrase Inhibitors; C027767:elliptinium; D000167:Acriflavine; D003035:Cobalt; D019427:HIV Integrase; D014805:Vitamin B 12