Highlights of semi-synthetic developments from erythromycin A.
Earlier semi-synthetic studies of erythromycin A culminated in the discovery of two successful second generation macrolide antibiotics, azithromycin and clarithromycin, for the treatment of community-acquired bacterial infections. More recent structural modifications of erythromycin A have resulted in the discovery of novel ketolide antibiotics and new motilide prokinetic agents. This review is an account of the semi-synthetic developments from erythromycin A by chemical transformations.
Wu
Y J
YJ
Pfizer Central Research, Eastern Point Road, Groton, Connecticut 06340, USA. Yong-Jin.Wu@bms.com
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D004917:Erythromycin / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D004917:Erythromycin