[Preparation and certain properties of the liposomal substance 2,4-di(1-methyl-3-hydroxybutyl)deuteroporphyrin-IX].
A liposome preparation of a porphyrin photosensitizer for photodynamic therapy of tumors (PDT) was obtained. The in vitro efficiency of the photosensitizer was enhanced 2.5-fold through the liposome formulation. The composition and some properties of the new preparation were studied. An algorithm for a complex approach to the prediction of photosensitizer efficiencies by model experiments in vitro was developed. This approach is based on the use of two models: the determination of coefficient of distribution between n-octanol and a phosphate buffer, pH 7.4, and the determination of the cytotoxic effect on the culture of CaOv ovarian adenocarcinoma cells.
Reshetnikov
A V
AV
Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia.
Zhigal'tsev
I V
IV
Kolomeĭchuk
S N
SN
Kaplun
A P
AP
Shvets
V I
VI
Zhukova
O S
OS
Karmenian
A V
AV
Ivanov
A V
AV
Ponomarev
G V
GV
D000230:Adenocarcinoma / Q000473:pathology; D003905:Deuteroporphyrins / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D010051:Ovarian Neoplasms / Q000473:pathology; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
C403943:2,4-di(1-methyl-3-hydroxybutyl)deuteroporphyrin-IX; D003905:Deuteroporphyrins; D008081:Liposomes; D017319:Photosensitizing Agents