[Prion phenomenon in medicine and biology].
The data obtained suggest that the fatal changes in brain tissue associated with the prion diseases, are initiated by a conformational rearrangement of constitutively expressed cellular protein PrP. Possible mechanisms of such a conversion of this protein are discussed. Existence of the proteins with the prion properties in low eukaryotes may determine the unusual mechanisms of the "protein" inheritance. A new experimental model for studying the proteins with the prion properties in the yeast Saccharomyces cerevisiae, is described.
Ter-Avanesian
M D
MD
Cardiological Research-Industrial Complex, Moscow, Russia.
Shitikova
I E
IE
Zavalishin
I A
IA
Smirnov
V N
VN
D000818:Animals; D005656:Fungal Proteins / Q000235:genetics; D006801:Humans; D017096:Prion Diseases / Q000235:genetics*; D011328:Prions / Q000737:chemistry / Q000235:genetics* / Q000472:pathogenicity; D011487:Protein Conformation
D005656:Fungal Proteins; D011328:Prions