Use of propofol to manage seizure activity after surgical treatment of portosystemic shunts.
The anaesthetic agent propofol has anticonvulsant properties and has been used in the treatment of refractory status epilepticus in human medicine. This report describes the use of propofol in four cats and one dog with naturally occurring seizures following surgical attenuation of single extrahepatic portosystemic shunts. Two of the animals had seizures that were unresponsive to other anticonvulsants. Subanaesthetic doses of intravenous propofol (1.0 to 3.5 mg/kg boluses and 0.01 to 0.25 mg/kg/minute continuous rate infusions) were used to control the seizures in all animals. However, a good neurological outcome was achieved in only two of the five cases, which is similar to the situation in previous reports.
Heldmann
E
E
Department of Clinical Studies, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104, USA.
Holt
D E
DE
Brockman
D J
DJ
Brown
D C
DC
Perkowski
S Z
SZ
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D011170:Portasystemic Shunt, Surgical / Q000009:adverse effects*; D015742:Propofol / Q000494:pharmacology / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*
D000927:Anticonvulsants; D015742:Propofol