title: Memory--a century of consolidation.
abstract: The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.
authors.affiliation: the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA. jlmcgaug@uci.edu
authors.forename: J L
authors.initials: JL
authors.lastname: McGaugh
mesh_terms: D000648:Amnesia, Retrograde / Q000503:physiopathology; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D004644:Emotions; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D011494:Protein Kinases / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000502:physiology
chemical_list: D011943:Receptors, Adrenergic, beta; D011494:Protein Kinases