Effect of the components extracted from the needles of Taxus baccata on protein biosynthesis in a cell-free rat liver system.
Various species of Taxus contain taxanes that promote polymerization and stabilization of microtubules. They have been reported as antineoplastic compounds with highly effective chemiotherapeutic application. A decrease in incorporation of the radiolabelled precursors into DNA, RNA and proteins in vivo has been reported too. The preliminary results have shown that also the other compounds present in the aqueous extract from Taxus baccata needles, participate in the inhibition of the protein biosynthesis. The binding site of eEF-2 on the ribosome seems to be the target of this inhibition process.
Sredzińska
K
K
Department of General and Organic Chemistry, Medical Academy, Białystok, Poland.
Gajko
A
A
Gałasiński
W
W
Gindzieński
A
A
D018663:Adrenergic Agents / Q000494:pharmacology; D000818:Animals; D002474:Cell-Free System; D004809:Ephedrine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D017239:Paclitaxel / Q000494:pharmacology*; D010445:Peptide Elongation Factors / Q000096:biosynthesis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D018663:Adrenergic Agents; D010445:Peptide Elongation Factors; D010936:Plant Extracts; D004809:Ephedrine; D017239:Paclitaxel