title: A comparison of fluoride bioavailability from a sustained-release NaF preparation (Neosten) and other fluoride preparations.
abstract: Twelve normal subjects completed a crossover study with sustained-release sodium fluoride (Neosten, 11.3 mg F), monofluorophosphate (MFP, 10 mg F), and plain sodium fluoride (P-NaF, 11.3 mg F). After each preparation was given with 400 mg calcium, serum fluoride (Fser) was measured for 24 hours, and pharmacokinetic data were calculated. Fluoride absorption in the Neosten group, as measured by change in the area under the curve (delta AUC) of Fser, was less than 33% of that in the MFP and P-NaF treated groups. Both peak Fser (Cmax) and peak-basal variation in the Neosten group were 25% that found in the other groups. t1/2 was nearly twofold greater after Neosten. MFP and P-NaF showed greater bioavailability than Neosten and much higher Cmax that exceeded the toxic threshold of Fser (190 ng/ml). These findings could explain the ineffectiveness of MFP and P-NaF observed in recent clinical trials.
authors.affiliation: Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas 75235-8885, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Gitomer
authors.forename: K
authors.initials: K
authors.lastname: Sakhaee
authors.forename: C Y
authors.initials: CY
authors.lastname: Pak
mesh_terms: D000328:Adult; D000368:Aged; D001682:Biological Availability; D003692:Delayed-Action Preparations; D005260:Female; D005459:Fluorides / Q000493:pharmacokinetics*; D006801:Humans; D008875:Middle Aged; D010710:Phosphates / Q000493:pharmacokinetics*; D012969:Sodium Fluoride / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D003692:Delayed-Action Preparations; D010710:Phosphates; C012980:fluorophosphate; D012969:Sodium Fluoride; D005459:Fluorides