title: Cerebral blood flow and metabolic changes produced by repetitive magnetic brain stimulation.
abstract: We evaluated cerebral variation in oxyhemoglobin, deoxyhemoglobin, and cytochrome oxidase before and after transcranial magnetic and electrical stimulation in ten healthy volunteers using near-infrared spectroscopy. Immediately after magnetic but not after electric stimulation a significant increase in oxyhemoglobin and a decrease in cytochrome oxidase were observed (P < 0.05). Our data suggest that repetitive transcranial magnetic stimulation induces metabolic activation of the cerebral cortex together with an increase in cerebral blood flow.
authors.affiliation: Istituto di Neurologia, Università Cattolica, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Oliviero
authors.forename: V
authors.initials: V
authors.lastname: Di Lazzaro
authors.forename: O
authors.initials: O
authors.lastname: Piazza
authors.forename: P
authors.initials: P
authors.lastname: Profice
authors.forename: M A
authors.initials: MA
authors.lastname: Pennisi
authors.forename: F
authors.initials: F
authors.lastname: Della Corte
authors.forename: P
authors.initials: P
authors.lastname: Tonali
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004558:Electric Stimulation; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D006801:Humans; D008280:Magnetics; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D010108:Oxyhemoglobins / Q000378:metabolism; D010812:Physical Stimulation / Q000379:methods; D019265:Spectroscopy, Near-Infrared
chemical_list: D010108:Oxyhemoglobins; D003576:Electron Transport Complex IV