The incorporation of a stent-graft into the porcine aorta and the inflammatory response to the endoprosthesis.
The fate of a non-sutured anastomosis and the inflammatory response to an endoprosthesis in a porcine aorta was determined. Self-expanding aorto-aortic endovascular prostheses were deployed into the infrarenal aorta of Large White pigs by the transfemoral route, in accordance with Home Office regulations. Animals were followed up at intervals to 1 year. The aortas were explanted and specimens were subjected to light microscopy. Thirteen animals, mean weight 103 kg, underwent placement of a prosthesis. There was early evidence of a neointima at 4 weeks and a well-developed neointima by 12 weeks, with complete incorporation of the endoprosthesis. The early acute inflammatory reaction seen at 4 weeks had become chronic by 12 and was largely absent by 26 weeks. There was no evidence of atypia. Complete incorporation of the non-sutured anastomosis is seen in this model. The acute inflammatory reaction to the prosthesis seen at 4 weeks had largely subsided by 26 weeks.
Lambert
A W
AW
Derriford Hospital, Department of Vascular Surgery, Plymouth, UK.
Budd
J S
JS
Fox
A D
AD
Potter
U
U
Rooney
N
N
Horrocks
M
M
D000208:Acute Disease; D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery*; D001025:Aortitis / Q000209:etiology* / Q000473:pathology; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D002908:Chronic Disease; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D015607:Stents / Q000009:adverse effects*; D013552:Swine; D017539:Tunica Intima / Q000473:pathology