title: Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group.
abstract: OBJECTIVE
  To determine maternal and perinatal outcomes in nulliparas with pregnancy-associated hypertension or preeclampsia.
  
  
  METHODS
  We conducted (and reported elsewhere) a randomized, double-masked, placebo-controlled trial calcium supplementation of 4589 healthy nulliparas assigned at 13-21 weeks' gestation. This well-defined and characterized data set provided an opportunity to detail more precisely adverse maternal, fetal, and newborn outcomes in women who developed hypertension among a prospective series of healthy nulliparas.
  
  
  RESULTS
  Of 4302 women observed to or beyond 20 weeks' gestation, 1073 (24.9%) developed mild or severe pregnancy-associated hypertension or preeclampsia. One hundred sixteen women of the 1073 with hypertension (10.8%) and 336 of the 3229 without hypertension (10.4%) were delivered before 37 weeks' gestation. Fetal and neonatal mortality were similar in those groups; however, selected maternal and newborn morbidities were significantly greater in women with hypertension. Significantly increased maternal morbidities included increased cesarean deliveries, abruptio placentae, and acute renal dysfunction; and significantly increased perinatal morbidities included respiratory distress syndrome, ventilatory support, and fetal growth restriction. Adverse outcomes were highest in women with severe pregnancy-associated hypertension or preeclampsia.
  
  
  CONCLUSIONS
  Hypertension, especially severe hypertension, was associated with an appreciable increase in important maternal and perinatal morbidity but not perinatal mortality.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alabama at Birmingham, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Hauth
authors.forename: M G
authors.initials: MG
authors.lastname: Ewell
authors.forename: R J
authors.initials: RJ
authors.lastname: Levine
authors.forename: J R
authors.initials: JR
authors.lastname: Esterlitz
authors.forename: B
authors.initials: B
authors.lastname: Sibai
authors.forename: L B
authors.initials: LB
authors.lastname: Curet
authors.forename: P M
authors.initials: PM
authors.lastname: Catalano
authors.forename: C D
authors.initials: CD
authors.lastname: Morris
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension; D011225:Pre-Eclampsia; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome