Apoptosis of perineurial cells in sensory perineuritis.
A 71-year-old man presented a 6-month history of progressive paresthesia of all four limbs. Sural nerve biopsy specimens showed dense mononuclear infiltrates in the perineurium and subperineurium, indicating sensory perineuritis. One section revealed disruption of the perineurial barrier. Perforin and granzyme B were present in the infiltrates, and apoptosis of perineurial cells was indicated by a terminal deoxynucleotidyl-transferase-mediated dUTP-digoxigenin nick end-labeling (TUNEL) method. These findings suggest T cell-mediated apoptosis of the perineurium and nerve injury caused by perineurial damage.
Oka
N
N
Department of Neurology, Kyoto University Hospital, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. oka@isola.kuhp.kyoto-u.ac.jp
Takahashi
M
M
Kawasaki
T
T
Akiguchi
I
I
D000368:Aged; D017209:Apoptosis; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology*; D010523:Peripheral Nervous System Diseases / Q000473:pathology*