Protective effect of various forms of superoxide dismutase on phospholipid composition of hepatocyte and adipocyte plasma membranes and blood lipoprotein spectrum during hemorrhagic shock on cats.
Using a model of hemorrhagic shock, the possibility of protection by Cu,Zn-superoxide dismutase (SOD) of the phospholipid bilayer of plasma membranes of hepatocytes and adipocytes as well as of the blood lipoproteins was studied. SOD (5 mg/kg), injected 30 min after the onset of bleeding, efficiently prevented changes in the phospholipid bilayer of hepatocytic plasma membranes in cats. Simultaneous injection of SOD partly restored the concentration of different classes of phospholipids in plasma membranes of mesenterial fatty tissue adipocytes altered by shock. When incorporated into liposomes, SOD exerted a weaker corrective effect on the phospholipid composition of hepatocytic plasma membranes in animals with hemorrhagic shock and simultaneously produced a membrane-stabilizing effect on adipocytes. In contrast to pure SOD (which had no effect on the lipoprotein composition of the blood in animals with hemorrhagic shock), SOD-containing liposomes decreased the amount of chylomicrons and very low density lipoproteins in the venous blood of central vessels.
Leskova
G F
GF
Institute of General Pathology and Pathophysiology, Moscow, Russia. nii@pathophys.msk.ru
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D002415:Cats; D002462:Cell Membrane / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000378:metabolism* / Q000648:ultrastructure; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D012771:Shock, Hemorrhagic / Q000378:metabolism* / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000494:pharmacology*
D016166:Free Radical Scavengers; D008074:Lipoproteins; D008563:Membrane Lipids; D010743:Phospholipids; D013482:Superoxide Dismutase