Recombinant human thyrotropin in thyroid cancer and hypopituitarism due to sella metastasis.
We present a patient with thyroid cancer and hypopituitarism who required recombinant human thyrotropin (rhTSH) for 131I scanning with respect to subsequent therapy. The thyroid cancer had been unknown until central neurological symptoms developed, leading to the diagnosis of a huge metastasis to the sella that was the only manifestation of metastatic spread. The failure to generate endogenous thyrotropin (TSH) was overcome by the use of rhTSH for performing a 131I test. Unfortunately, the 131I uptake was not sufficient for therapy. This subject is the first reported case who required the application of rhTSH due to a single thyroid cancer metastasis in the sella region with secondary failure to generate endogenous TSH.
Risse
J H
JH
Department of Nuclear Medicine, University Hospital of Bonn, Germany. JRisse@mailer.meb.uni-bonn.de
Grünwald
F
F
Bender
H
H
Schüller
H
H
Van Roost
D
D
Biersack
H J
HJ
D000368:Aged; D001859:Bone Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D005260:Female; D006801:Humans; D007018:Hypopituitarism / Q000188:drug therapy* / Q000209:etiology*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008279:Magnetic Resonance Imaging; D011877:Radionuclide Imaging; D011994:Recombinant Proteins / Q000627:therapeutic use; D012658:Sella Turcica / Q000000981:diagnostic imaging / Q000473:pathology; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000172:deficiency / Q000627:therapeutic use*
D007457:Iodine Radioisotopes; D011994:Recombinant Proteins; D013972:Thyrotropin