title: Prostaglandin E2 in preinduction cervical ripening in postdate pregnancy.
abstract: Unripe cervix is a widely recognised factor contributing to the failure to induce labour. Its presence is associated with high frequency of operative delivery, adverse fetal outcome and high maternal morbidity.
  
  
  METHODS
  We studied the efficacy of PGE2 application for preinduction cervical ripening in women with postdate pregnancy. Two PGE2-containing preparations were used--Prepidil-gel and Prostin E2 (Upjohn). They were administered to 42 women with postdate pregnancy, unripe cervices and indications for labour induction. The study sample was divided into two groups: group I (20 women) received Prepidil-gel, group II (22 women)--Prostin E2.
  
  
  RESULTS
  85.7% of the women responded favourably to the ripening effect of PGE2. There was no difference in the efficacy, safety and outcome of pregnancy between the two groups.
  
  
  CONCLUSIONS
  Prostaglandin PGE2 is effective for preinduction cervical ripening in women with postdated pregnancy. The authors give their preference to Prostin E2 because it is easier to apply.
authors.affiliation: Department of Obstetrics and Gynecology, Higher Medical Institute, Plovdiv, Bulgaria.
authors.forename: N
authors.initials: N
authors.lastname: Milchev
authors.forename: B
authors.initials: B
authors.lastname: Pehlivanov
authors.forename: V
authors.initials: V
authors.lastname: Paskaleva
authors.forename: G
authors.initials: G
authors.lastname: Velchev
authors.forename: A
authors.initials: A
authors.lastname: Gurova
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D020070:Cervical Ripening / Q000187:drug effects*; D015232:Dinoprostone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007751:Labor, Induced; D011247:Pregnancy; D011256:Pregnancy Outcome; D011273:Pregnancy, Prolonged / Q000187:drug effects*
chemical_list: D015232:Dinoprostone