title: Preserved extrinsic neural connection between gallbladder and residual stomach is essential to prevent dysmotility of gallbladder after distal gastrectomy.
abstract: Many reports have been made on gallbladder dysfunction after gastric surgery. We reported that the gallbladder contractions were abolished after antrectomy. Our hypothesis is that preservation of the neural connection along gastric vessels maintains normal gallbladder function during fasting after antrectomy. Six dogs underwent antrectomy with preservation of the extrinsic nerves and six other dogs underwent conventional antrectomy with dissection of the extrinsic nerves and vessels. Laparotomy alone was performed on another six control dogs. Motor activities of the gallbladder and upper gastrointestinal tract were recorded by strain gauges in conscious dogs. Motilin and CCK-OP were used for pharmacological interventions. In conventional antrectomy, the amplitudes of the cyclic motor activity of the gallbladder and the stomach during fasting were significantly reduced, while this activity was maintained in dogs when extrinsic nerves were preserved. The coordination of the motor activity among the gallbladder, stomach and the duodenum was not impaired in the dogs when extrinsic nerves were preserved. The contractions of the gallbladder induced by exogenous motilin were reduced significantly in conventional antrectomy. Therefore, the preserved neural connection along the gastric vessels maintains normal gallbladder function in the fasting state even after distal gastrectomy.
authors.affiliation: Department of Surgery II, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Tsukamoto
authors.forename: A
authors.initials: A
authors.lastname: Enjoji
authors.forename: K
authors.initials: K
authors.lastname: Ura
authors.forename: T
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D000818:Animals; D004285:Dogs; D004386:Duodenum / Q000294:innervation / Q000502:physiology; D005260:Female; D005704:Gallbladder / Q000294:innervation* / Q000502:physiology*; D016473:Gallbladder Emptying / Q000187:drug effects / Q000502:physiology; D005743:Gastrectomy / Q000379:methods*; D005746:Gastric Emptying / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D008297:Male; D009037:Motilin / Q000494:pharmacology; D010507:Periodicity; D011183:Postoperative Complications / Q000517:prevention & control; D012844:Sincalide / Q000494:pharmacology; D013270:Stomach / Q000294:innervation* / Q000502:physiology / Q000601:surgery*; D014628:Vagotomy
chemical_list: D009037:Motilin; D012844:Sincalide