[Protein glycation--clinical and chemical aspects].
Glucose as well as other reducing sugars react nonenzymatically with amino groups of free amino acids, peptides and proteins. Glycation reaction is responsible for forming inter- and intramolecular cross-links of proteins, known as advanced glycation end-products (AGEs). In old people, patients with diabetes and chronic failure AGEs accumulate in the circulation and tissues, and play a significant role in pathogenesis of cardiovascular and other complications. Glycation reactions has been used for synthesis of artificial glycoconjugates.
Szymańska
U
U
Zakład Immunologii Nowotworów, Instytut Immunologii i Terapii Doświadczalnej PAN, Ludwika Hirszfelda we Wrocławiu.
Boratyński
J
J
D000375:Aging / Q000378:metabolism; D002386:Cataract / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D017127:Glycation End Products, Advanced; D011506:Proteins