title: Flumazenil reversal of carisoprodol (Soma) intoxication.
abstract: A 52-year-old woman presented with central nervous system depression and a Glasgow Coma Score of 9 secondary to ingestion of carisoprodol, a centrally acting muscle relaxant analgesic. After administration of i.v. flumazenil, the patient's neurologic status normalized and she required no further therapy. Carisoprodol and its active sedative-hypnotic metabolite, meprobamate, are gamma aminobutyric acid receptor indirect agonists with central nervous system chloride ion channel conduction effects similar to the benzodiazepines, thus making flumazenil a potentially useful antidote in toxic presentations.
authors.affiliation: Department of Emergency Medicine, Western Pennsylvania Hospital, Pittsburgh 15224, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Roberge
authors.forename: E
authors.initials: E
authors.lastname: Lin
authors.forename: E P
authors.initials: EP
authors.lastname: Krenzelok
mesh_terms: D000931:Antidotes / Q000627:therapeutic use*; D002328:Carisoprodol / Q000506:poisoning*; D002490:Central Nervous System / Q000187:drug effects*; D004630:Emergencies; D005260:Female; D005442:Flumazenil / Q000627:therapeutic use*; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000506:poisoning*
chemical_list: D000931:Antidotes; D018757:GABA Modulators; D009125:Muscle Relaxants, Central; D002328:Carisoprodol; D005442:Flumazenil