Efficient Hydrolysis of RNA by a PNA - Diethylenetriamine Adduct.
The introduction of a urea bond linking a protected diethylenetriamine (DETA) unit and the terminal amino group of a resin-bound peptide nucleic acid (PNA) decamer gave access to a PNA - DETA adduct (shown here), which hydrolyzed the target 25-mer RNA rapidly and sequence specifically.
Verheijen
JC
Leiden Institute of Chemistry Gorlaeus Laboratories, P.O. Box 9502, 2300 RA Leiden (The Netherlands).
Deiman
BA
Yeheskiely
E
van Der Marel GA
van Boom JH