Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers.
An aqueous solution of newly developed low-molecular-weight PEG-PLGA-PEG triblock copolymers with a specific composition is a free flowing sol at room temperature but becomes a gel at body temperature. Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37 degrees C aqueous environment. Ketoprofen (a model hydrophilic drug) was released over 2 weeks with a first-order release profile, while spironolactone (a model hydrophobic drug) was released over 2 months with an S-shaped release profile. The release profiles were simulated by models considering degradation and diffusion, and were better described by a model assuming a core-shell structure of the gel.
Jeong
B
B
Biomedical Polymers Research Building, Room 205, CCCD/Pharmaceutics, University of Utah, Salt Lake City, UT, USA.
Bae
Y H
YH
Kim
S W
SW
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D001673:Biodegradation, Environmental; D003692:Delayed-Action Preparations; D004232:Diuretics / Q000008:administration & dosage / Q000737:chemistry; D004355:Drug Stability; D006358:Hot Temperature; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry*; D007267:Injections; D007660:Ketoprofen / Q000008:administration & dosage / Q000737:chemistry; D007700:Kinetics; D008823:Micelles; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry*; D011098:Polyglactin 910 / Q000008:administration & dosage / Q000737:chemistry*; D013148:Spironolactone / Q000008:administration & dosage / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004232:Diuretics; D020100:Hydrogels; D008823:Micelles; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; D013148:Spironolactone; D011098:Polyglactin 910; D011092:Polyethylene Glycols; D007660:Ketoprofen