title: Rolling Loop Scan: An Approach Featuring Ring-Closing Metathesis for Generating Libraries of Peptides with Molecular Shapes Mimicking Bioactive Conformations or Local Folding of Peptides and Proteins.
abstract: Libraries of loop-containing peptides (such as the one shown schematically) can be prepared from bis-N-alkylated peptides by ring-closing metathesis. In a general solid-phase procedure the peptides are accessible by site-specific N-alkylation. Since the amino acid side chains are not involved in cyclization, they remain available for interaction with, for example, a receptor.
authors.affiliation: Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P. O. Box 80082, NL-3508 TB Utrecht (The Netherlands).
authors.initials: JF
authors.lastname: Reichwein
authors.initials: B
authors.lastname: Wels
authors.initials: JA
authors.lastname: Kruijtzer
authors.initials: C
authors.lastname: Versluis
authors.initials: RM
authors.lastname: Liskamp