title: EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-- descriptive characteristics.
abstract: The Epidemiological study on the Genetics and Environment of Asthma (EGEA) was planned to assess genetic, environmental risk factors and their interactions for asthma and for the two related traits of bronchial hyperresponsiveness and atopy. The population examined includes 348 nuclear families ascertained by one asthmatic (213 adult and 135 paediatric probands) and 416 controls, totalling 1,847 subjects (EGEA I). Prevalences of asthma, skin prick test response, high IgE and bronchial hyperresponsiveness were for parents, siblings, and offspring of cases intermediate between cases and spouses or controls, both in adults and children, confirming the familial resemblance for asthma and related traits. With an additional sample of 40 families ascertained by two asthmatic siblings (EGEA II), a total of 119 families with two asthmatic siblings has been ascertained for a genome screening.
authors.affiliation: INSERM U472, Villejuif, France.
authors.forename: F
authors.initials: F
authors.lastname: Kauffmann
authors.forename: M H
authors.initials: MH
authors.lastname: Dizier
authors.forename: I
authors.initials: I
authors.lastname: Annesi-Maesano
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
authors.forename: D
authors.initials: D
authors.lastname: Charpin
authors.forename: F
authors.initials: F
authors.lastname: Demenais
authors.forename: D
authors.initials: D
authors.lastname: Ecochard
authors.forename: J
authors.initials: J
authors.lastname: Feingold
authors.forename: F
authors.initials: F
authors.lastname: Gormand
authors.forename: A
authors.initials: A
authors.lastname: Grimfeld
authors.forename: M
authors.initials: M
authors.lastname: Lathrop
authors.forename: R
authors.initials: R
authors.lastname: Matran
authors.forename: F
authors.initials: F
authors.lastname: Neukirch
authors.forename: E
authors.initials: E
authors.lastname: Paty
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.forename: C
authors.initials: C
authors.lastname: Pison
authors.forename: P
authors.initials: P
authors.lastname: Scheinmann
authors.forename: D
authors.initials: D
authors.lastname: Vervloet
authors.forename: A
authors.initials: A
authors.lastname: Lockhart
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000209:etiology / Q000235:genetics*; D016535:Bronchial Hyperreactivity / Q000209:etiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D004777:Environment; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000235:genetics*; D007223:Infant; D008297:Male; D012307:Risk Factors