[Clinical course of symptomatic duodeno-jejunal Crohn's disease].
OBJECTIVE
To describe retrospectively the characteristics of inaugural, symptomatic Crohn's disease of the upper gastrointestinal tract.


METHODS
Eighteen patients (12 male and 6 female) with symptomatic Crohn's disease of the upper intestinal tract and without previous distal localisation were studied.


RESULTS
Mean age of patients at diagnosis (21.3 years) was less than that usually reported in Crohn's disease. The time elapsed from first symptoms to diagnosis (mean = 29.8 months) was remarkably long for some patients, mainly as a result of an unusual clinical presentation. Abdominal pain and weight loss were the most common presenting features; diarrhea was rarely the main symptom. Persistent anorexia and weight loss without digestive symptoms had led to a diagnosis of anorexia nervosa in 4 patients. Zollinger-Ellison syndrome was the initial diagnosis in 3 other patients. Sixteen patients were followed during at least 2 years. All were treated with steroids for their first attack and 75 % required immunosuppressive therapy for steroid dependence. At the end of follow-up, 6 patients only were in remission without treatment or under mesalamine.


CONCLUSIONS
Crohn's disease with initial symptomatic lesions of the upper gastrointestinal tract occurs mainly in young male patients. The clinical presentation may be very unusual, leading to misdiagnosis. The clinical course is close to that of diffuse jejunoileitis.
Andant
C
C
Services d'Hépato-Gastroenterologie, Hôpital Louis-Mourier, Colombes.
Godeberge
B
B
Chaussade
S
S
Dupas
J L
JL
Soulé
J C
JC
D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D004378:Duodenal Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D006801:Humans; D007579:Jejunal Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D008297:Male; D012189:Retrospective Studies