Phenotypic mapping of human mesothelial cells.
In recent years it has become clear that the mesothelium plays a prominent homeostatic role in the peritoneum, and can be profoundly altered in disease and during peritoneal dialysis. The cell-surface phenotype of the mesothelial cell has not been thoroughly investigated. This study begins to identify cell surface molecules which may be important in mesothelial functions such as adhesion and interaction with cells of the immune system. The expression of adhesion structures on mesothelial cells such as CD44, the beta integrin chain CD29, the beta 3 integrin chain CD61 and alpha chains CD49 alpha (alpha 1), CD49b (alpha 2), CD49c (alpha 3), CD49e (alpha 5), and CD51 (alpha v) is described. In addition, a wide range of novel molecules including CD90, CD105, CD140b, CD142, CD147, CD151, CD157, CD165, and CD166 are identified. The role and function of such molecules in mesothelial biology and their significance for peritoneal dialysis is discussed.
Ross
J A
JA
Molecular Immunology Group, University Department of Surgery, Royal Infirmary, Edinburgh, United Kingdom.
Ansell
I
I
Hjelle
J T
JT
Anderson
J D
JD
Miller-Hjelle
M A
MA
Dobbie
J W
JW
D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis; D002478:Cells, Cultured; D004847:Epithelial Cells / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D016023:Integrins / Q000032:analysis; D010537:Peritoneum / Q000166:cytology*
D015703:Antigens, CD; D000954:Antigens, Surface; D015815:Cell Adhesion Molecules; D016023:Integrins