Solid-Phase Synthesis of a Monofunctional trans-a(2)Pt(II) Complex Tethered to a Single-Stranded Oligonucleotide.
Cross-linking ability is possible with the oligonucleotide-tethered, monofunctional trans-Pt(II) complex shown. It was synthesized by a novel solid-phase approach comprising conjugation of immobilized tetrathymidylic acid with a trans-a(2)Pt(II) building unit, ammonolysis, and transformation of the resulting complex (R=1-N-cyclohexylmethylthyminate) into the chloro derivative (R=Cl). a=NH(2)CH(3), T=thymine.
Schmidt
KS
Leiden Institute of Chemistry Gorlaeus Laboratories, Leiden University 2300 RA Leiden (The Netherlands).
Filippov
DV
Meeuwenoord
NJ
van Der Marel GA
van Boom JH
Lippert
B
Reedijk
J