title: Dipole-source analysis in a realistic head model in patients with focal epilepsy.
abstract: OBJECTIVE
  By the use of three different head models in EEG dipole analysis, we tried to model the origin of interictal and ictal epileptic activity as precisely as possible. Further, as a control, a second evaluation was made by an independent group to control for interindividual reliability of the dipole source analysis. With the realistic head model (CURRY) considering cortex, skull, and skin segmentation, the spike source was located.
  
  
  METHODS
  In five patients with mesial temporal epileptogenesis, confirmed by successful epilepsy surgery, the spike source was close to the hippocampus, with a mean distance of the dipole source from the hippocampus of 13.6 mm (range, 9-17.2 mm). In one case the ictal EEG also could be analyzed and resulted in a dipole-source localization comparable to the interictal source.
  
  
  RESULTS
  In both head models using either pure cortex segmentation only or a concentric three-shell model, the dipole source was systematically dislocated in a more superior position. Data analysis by a second group with independently chosen EEG samples and identical individual head model resulted in deviations of <5.3 mm. Data analysis using independently selected spikes and independently segmented head models resulted in deviations < or =16.7 mm.
  
  
  CONCLUSIONS
  In four cases of extratemporal epileptogenesis, the origin of interictal epileptiform discharges was localized to the suspected primary epileptogenic zone.
authors.affiliation: Department of Clinical Neurophysiology, Georg-August University of Göttingen, Germany. G.Herrendorf@med.uni.goettingen.de
authors.forename: G
authors.initials: G
authors.lastname: Herrendorf
authors.forename: B J
authors.initials: BJ
authors.lastname: Steinhoff
authors.forename: R
authors.initials: R
authors.lastname: Kolle
authors.forename: J
authors.initials: J
authors.lastname: Baudewig
authors.forename: T D
authors.initials: TD
authors.lastname: Waberski
authors.forename: H
authors.initials: H
authors.lastname: Buchner
authors.forename: W
authors.initials: W
authors.lastname: Paulus
mesh_terms: D000328:Adult; D002648:Child; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000503:physiopathology*; D017034:Epilepsy, Frontal Lobe / Q000503:physiopathology; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D010296:Parietal Lobe / Q000503:physiopathology; D012815:Signal Processing, Computer-Assisted; D014584:User-Computer Interface