The prognostic implications of outpatient diuretic dose in heart failure.
In 111 patients with left ventricular ejection fraction < or =30% who required hospitalization for heart failure, we examined the association between outpatient dose of diuretic agents and all-cause mortality. In comparison to patients who were not on treatment with diuretics prior to hospitalization, patients being treated with 'low' doses of diuretics (<80 mg/day of furosemide) and those being treated with 'high' doses of diuretics (> or =80 mg/day of furosemide) were more likely to die during follow-up after adjustment for other clinical parameters (adjusted relative risks, RR, 3.1 and 4.6).
Harjai
K J
KJ
Department of Cardiology, Ochsner Clinic, New Orleans, LA, USA. kharjai@ochsner.org
Dinshaw
H K
HK
Nunez
E
E
Shah
M
M
Thompson
H
H
Turgut
T
T
Ventura
H O
HO
D000368:Aged; D004232:Diuretics / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000008:administration & dosage*; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008297:Male; D010045:Outpatients; D012189:Retrospective Studies; D012307:Risk Factors; D013318:Stroke Volume; D015996:Survival Rate; D016896:Treatment Outcome
D004232:Diuretics; D005665:Furosemide