title: Anaerobic power and muscle strength in young hemophilia patients.
abstract: OBJECTIVE
  The purpose of this study was to evaluate muscle strength and anaerobic power in young boys with hemophilia compared with healthy boys.
  
  
  METHODS
  Thirteen boys with severe hemophilia (H) (mean (+/- SD) age = 12.0 +/- 3.17 yr) and 16 control (C) boys (age = 11.9 +/- 2.8 yr) performed elbow and knee flexion and extension on the Biodex System II dynamometer at two angular velocities. They also performed a Wingate Anaerobic Test (WAnT) for the legs and for the arms. All H subjects received prophylactic factor VIII treatment in the 24 h pretesting, and no test was performed in the presence of hemorrhage.
  
  
  RESULTS
  C were consistently stronger than H in all dynamic strength measures (e.g., elbow flexors: 0.47 +/- 0.15 vs 0.36 +/- 0.08 N x m x kg(-1) for C and H, respectively, P < 0.05). Anaerobic mean power was also higher in C compared with H in both upper and lower extremities (arms: 3.08 +/- 0.99 vs 2.22 +/- 0.46 W x kg(-1) for C and H, respectively; legs: 6.94 +/- 1.62 vs 5.54 +/- 1.03 W x kg(-1) for C and H, respectively, P < 0.05). Upper and lower extremity strength, as well as anaerobic power, increased with age in C but not in H. By using the Godin Leisure-Time Exercise Questionnaire, H were found to be much less active, especially in intense activities, compared with C.
  
  
  CONCLUSIONS
  Children and adolescents with hemophilia are characterized by lower muscle strength and anaerobic power compared with age-matched controls. This may be related to their lower leisure-time activity.
authors.affiliation: Ribstein Center for Sport Medicine Sciences and Research, Wingate Institute, Israel. bfalk@post.tau.ac.il
authors.forename: B
authors.initials: B
authors.lastname: Falk
authors.forename: S
authors.initials: S
authors.lastname: Portal
authors.forename: R
authors.initials: R
authors.lastname: Tiktinsky
authors.forename: Y
authors.initials: Y
authors.lastname: Weinstein
authors.forename: N
authors.initials: N
authors.lastname: Constantini
authors.forename: U
authors.initials: U
authors.lastname: Martinowitz
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015308:Anaerobic Threshold / Q000502:physiology*; D000693:Anaerobiosis; D001132:Arm / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D003029:Coagulants / Q000627:therapeutic use; D004551:Elbow Joint / Q000502:physiology; D005080:Exercise Test; D005169:Factor VIII / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D007866:Leg / Q000502:physiology; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology*; D016059:Range of Motion, Articular / Q000502:physiology; D013997:Time Factors
chemical_list: D003029:Coagulants; D005169:Factor VIII