[The mechanism of the transport of organophosphorus compounds across the histo-hematic barriers].
It was demonstrated in experiments on mice [correction of rats] that the transport of organophosphorus compounds (OPC) through membranes of the histohematic barriers (HHB) of the organism occurs by means of diffusion. The rate of this process depends on the interaction of OPC with the specific sites of binding with the tissues, among which the enzyme carboxylesterase plays an important part. It is suggested that both the rate and direction of OPC diffusion are determined by the relationship between the values of affinity of the ligands for the sites of their specific binding found on both sides of the HHB.
Miroshkina
V N
VN
Laboratory of Toxicology, City Laboratory Center, St. Petersburg, Russia.
Kosmachev
A B
AB
Salova
L S
LS
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000493:pharmacokinetics* / Q000633:toxicity; D004058:Diffusion / Q000187:drug effects; D007531:Isoflurophate / Q000493:pharmacokinetics* / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010949:Plasma / Q000187:drug effects / Q000378:metabolism*; D014018:Tissue Distribution / Q000187:drug effects; D014236:Trichlorfon / Q000493:pharmacokinetics* / Q000633:toxicity; D014316:Tritium; D014317:Tritolyl Phosphates / Q000493:pharmacokinetics* / Q000633:toxicity
D002800:Cholinesterase Inhibitors; D014317:Tritolyl Phosphates; D014316:Tritium; D007531:Isoflurophate; D014236:Trichlorfon; C025541:tri-o-cresyl phosphate