title: Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex.
abstract: A puzzling feature of the neocortex is the rich array of inhibitory interneurons. Multiple neuron recordings revealed numerous electrophysiological-anatomical subclasses of neocortical gamma-aminobutyric acid-ergic (GABAergic) interneurons and three types of GABAergic synapses. The type of synapse used by each interneuron to influence its neighbors follows three functional organizing principles. These principles suggest that inhibitory synapses could shape the impact of different interneurons according to their specific spatiotemporal patterns of activity and that GABAergic interneuron and synapse diversity may enable combinatorial inhibitory effects in the neocortex.
authors.affiliation: Department of Neurobiology, The Weizmann Institute for Science, 76100 Rehovot, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Markram
mesh_terms: D000200:Action Potentials; D000818:Animals; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure; D066298:In Vitro Techniques; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D019579:Neocortex / Q000166:cytology* / Q000502:physiology; D009433:Neural Inhibition; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000166:cytology / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D005680:gamma-Aminobutyric Acid; D011188:Potassium