title: A particularly aggressive combined glucagonoma and gastrinoma syndrome.
abstract: Duodeno-pancreatic biochemically polyfunctional endocrine tumour is a well known entity. Usually, only one hormone is responsible for the clinical features. We report a case of aggressive combined glucagonoma and gastrinoma tumour without metastases, causing respectively diabetic ketoacidosis and fulminant peptic ulcer, and death. Occasional patients can present with clinical features of both glucagonoma and gastrinoma. Diabetic patients exhibiting migratory skin lesions should be suspected of glucagonoma. In addition, a multidisciplinary approach to such patients including dermatologists, surgeons, radiologists and endoscopists is mandatory.
authors.affiliation: Department of Hepatology, Antoine Béclère Hospital, Clamart, France.
authors.forename: A
authors.initials: A
authors.lastname: Balian
authors.forename: C
authors.initials: C
authors.lastname: Fromont
authors.forename: S
authors.initials: S
authors.lastname: Naveau
authors.forename: E
authors.initials: E
authors.lastname: Bonte
authors.forename: D
authors.initials: D
authors.lastname: Belloula
authors.forename: V
authors.initials: V
authors.lastname: Giraud
authors.forename: S
authors.initials: S
authors.lastname: Montembault
authors.forename: F
authors.initials: F
authors.lastname: Capron
authors.forename: J C
authors.initials: JC
authors.lastname: Chaput
mesh_terms: D000328:Adult; D016883:Diabetic Ketoacidosis / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D015408:Gastrinoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D005935:Glucagonoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D010437:Peptic Ulcer / Q000209:etiology