title: Near-tetraploid minimally differentiated acute myeloid leukemia with extensive erythrophagocytosis by leukemic blasts.
abstract: Numerical change of chromosomes is common in acute myeloid leukemia (AML). However, a chromosome number as high as near-tetraploidy is very rare, especially in minimally differentiated AML (AML-M0). Erythrophagocytosis by reactive or malignant histiocytes is common in malignant hematological diseases; however, erythrophagocytosis by leukemic blasts is also very rare, especially in AML-M0. We report here the first case of AML-M0 with both of these unique characteristics: a near-tetraploid karyotype and erythrophagocytosis by leukemic blasts.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, China Medical College Hospital, 2 Yu Teh Road, Taichung, Taiwan. t5408@hpd.cmch.org.tw
authors.forename: S P
authors.initials: SP
authors.lastname: Yeh
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Su
authors.forename: E
authors.initials: E
authors.lastname: Hsueh
authors.forename: M
authors.initials: M
authors.lastname: Yu
authors.forename: H
authors.initials: H
authors.lastname: Wu
mesh_terms: D000208:Acute Disease; D000328:Adult; D000782:Aneuploidy; D001752:Blast Crisis / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics* / Q000473:pathology*; D008297:Male; D010587:Phagocytosis / Q000502:physiology*