title: [Prevention of wasting and opportunistic infections in HIV-infected patients in West Africa: a realistic and necessary strategy before antiretroviral treatment].
abstract: The medical inequalities between countries of the North and South (infrastructure, drug availability, medical techniques) are particularly marked in terms of the challenge posed by HIV infection. We propose a strategy for monitoring adult patients in West Africa that is appropriate to the situation in the field and to economic constraints. The aim of this strategy is to increase the quality of life and the life expectancy of HIV-infected adults and to prevent the overcrowding of hospital departments with patients in the terminal phase of AIDS. We analyzed the biological and clinical spectrum of HIV infection before the onset of the diseases that define AIDS (excluding pulmonary tuberculosis). We found that it was particularly important to diagnose B-stage diseases early, especially atypical chronic cutaneous and mucous diseases. Careful analysis of data from a routine hemogram (total lymphocyte count 2500/ml; paradoxical eosinopenia), even in the absence of a CD4 lymphocyte count, should also enable clinicians from a wide variety of health structures to identify the HIV-infected patients most likely to benefit from more detailed clinical follow up, prophylaxis of opportunistic infections using cotrimoxazole, nutritional checkups and prevention of wasting. Cachexia is the most common AIDS-associated disease in West African patients. It involves an overall decrease in calorific intake, diarrhea, immune system activation, an increase in TNFalpha production and greater energy expenditure when resting. Recent nutritional studies have shown that it is vital to optimize the calorific intake of HIV-infected patients presenting with chronic diarrhea, before the onset of severe immune deficiency, to prevent wasting. So, spontaneous calorific intake should de routinely determined in HIV-infected patients and an optimal diet provided. Specific training in nutrition is required for doctors and nurses, as is consideration of the logistic organization required to provide nutritional support to HIV-infected adults. Despite the large number of individuals infected and the lack of sophisticated paraclinical facilities, we feel that it is possible to establish rational management "a minima" of HIV infection in West Africa, whilst waiting for antiretroviral drugs to become more widely available. This strategy could be of direct benefit to patients without swallowing up the financial resources of the health system in expensive biological follow up. Such basic management is also required before the new antiretroviral drugs become widely available. Research should be carried out in parallel in several reference centers in West Africa to determine the most effective associations of antiretroviral drugs and the optimal timing of treatment during the course of infection and to assess the potential side effects of these drugs in HIV patients exposed to recurrent antigenic stimulation by a wide diversity of pathogens.
authors.affiliation: Unité d'oncologie virale, Institut Pasteur, 28, rue du Dr-Roux, 75724 Paris Cedex 15, France. erilledru@pasteur.fr
authors.lastname: Ledru é
authors.forename: P T
authors.initials: PT
authors.lastname: Sanou
authors.forename: M
authors.initials: M
authors.lastname: Dembele
authors.forename: H
authors.initials: H
authors.lastname: Dahourou
authors.forename: A
authors.initials: A
authors.lastname: Zoubga
authors.forename: G
authors.initials: G
authors.lastname: Durand
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002050:Burkina Faso; D002100:Cachexia / Q000503:physiopathology / Q000517:prevention & control; D003695:Delivery of Health Care / Q000191:economics; D004359:Drug Therapy, Combination; D002149:Energy Intake; D004804:Eosinophils / Q000473:pathology; D005500:Follow-Up Studies; D015658:HIV Infections / Q000145:classification / Q000503:physiopathology / Q000517:prevention & control*; D019247:HIV Wasting Syndrome / Q000517:prevention & control*; D006295:Health Resources; D006801:Humans; D007108:Immune Tolerance; D007970:Leukopenia / Q000145:classification; D008017:Life Expectancy; D018655:Lymphocyte Count; D015596:Nutrition Assessment; D018529:Nutritional Support; D010343:Patient Admission; D011788:Quality of Life; D012874:Skin Diseases, Infectious / Q000517:prevention & control; D013727:Terminal Care
chemical_list: D019380:Anti-HIV Agents