Peri-optic nerve infiltration during leukaemic relapse: MRI diagnosis.
BACKGROUND
A 10-year-old boy with a history of acute lymphoblastic leukaemia (ALL), but without previous evidence of central nervous system involvement, presented with seizures 3 years after complete remission.


METHODS
MRI showed bilateral enlargement of the optic nerves despite normal ophthalmological examination.


RESULTS
Only the third cerebrospinal fluid examination showed 2 % blasts without concomitant bone-marrow infiltration. Enlargement of the optic nerves was consistent with bilateral leukaemic peri-optic nerve infiltration. The appearances returned to normal after chemotherapy.


CONCLUSIONS
The optic nerves are a potential site of relapse in patients with systemic and meningeal ALL, even in the absence of ophthalmological signs.
Madani
A
A
Department of Imaging, Hôpital Universitaire des Enfants Reine Fabiola, 15 Avenue J. J. Crocq, B-1020 Brussels, Belgium.
Christophe
C
C
Ferster
A
A
Dan
B
B
D002648:Child; D006801:Humans; D017254:Leukemic Infiltration / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009900:Optic Nerve / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D012008:Recurrence