title: 99mTc-MIBI scan in mammary Pagets disease: a case report.
abstract: Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) uptake is known to be increased in breast cancer because of increased blood flow from angiogenesis and heightened metabolism. We performed a 99mTc-MIBI scan in a patient with mammary Paget's disease. The patient had underlying invasive cancer in the same side of the breast. 99mTc-MIBI scan exhibited a scintigraphic image of the uptake from the invasive cancer lesion located deeply in the breast toward the epidermis. 99mTc-MIBI showed an uptake in the deeply located invasive cancer lesion as well as nipple lesion. Especially, the delayed phase of Tc-MIBI scan demonstrated the tumor site more accurately. In conclusion, 99mTc-MIBI scan could be a useful adjunct to clinical decision making in the management of Paget's disease of the breast.
authors.affiliation: Department of Surgery, Inje University Sanggye Paik Hospital, Seoul, Korea. shwhan@unitel.co.kr
authors.forename: S
authors.initials: S
authors.lastname: Han
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: B S
authors.initials: BS
authors.lastname: Kim
authors.forename: I H
authors.initials: IH
authors.lastname: Koh
authors.forename: K
authors.initials: K
authors.lastname: Park
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009558:Nipples / Q000473:pathology; D010144:Paget's Disease, Mammary / Q000000981:diagnostic imaging* / Q000473:pathology; D011877:Radionuclide Imaging; D012867:Skin / Q000473:pathology; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi