An in vivo mouse micronucleus assay on musk ketone.
Musk ketone (3,5-dinitro-2,6-dimethyl-4-tert-butyl-acetophenone) was evaluated in an in vivo mouse micronucleus assay. Male and female mice were dosed with 250, 500 or 1000 mg musk ketone/kg body weight by a single intraperitoneal injection in corn oil. Results of the assay showed that under the conditions of this test evaluated at 24, 48 and 72 h after dosing, musk ketone did not induce a significant increase in micronucleated polychromatic erythrocytes in either male or female mice at any dose or any time period. Musk ketone was considered to be negative in the mouse in vivo micronucleus test as well as in a battery of previously published in vitro genotoxicity tests. Based on the total weight of evidence available, it was concluded that musk ketone does not have significant potential to act as a genotoxic carcinogen.
Api
A M
AM
Research Institute for Fragrance Materials, 2 University Plaza Drive, Suite 406, Hackensack, NJ, USA. api@rifm.org
Gudi
R
R
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002452:Cell Count / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004900:Erythroblasts / Q000166:cytology / Q000187:drug effects*; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D020714:Maximum Tolerated Dose; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D014992:Xylenes / Q000008:administration & dosage / Q000633:toxicity*
D014992:Xylenes; C031448:musk ketone; D003520:Cyclophosphamide