title: Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats.
abstract: The leaves of Moringa oleifera Lam (Moringaceae) are used by the Indians in their herbal medicine as a hypocholesterolemic agent in obese patients. The scientific basis for their use in hypercholesterolemia was therefore examined. It was found that administration of the crude leaf extract of Moringa oleifera along with high-fat diet decreased the high-fat diet-induced increases in serum, liver, and kidney cholesterol levels by 14.35% (115-103.2 mg/100 ml of serum), 6.40% (9.4-8.8 mg/g wet weight) and 11.09% (1.09-0.97 mg/g wet weight) respectively. The effect on the serum cholesterol was statistically significant. No significant effect on serum total protein was observed. However, the crude extract increased serum albumin by 15.22% (46-53 g/l). This value was also found to be statistically significant. It was concluded that the leaves of Moringa oleifera have definite hypocholesterolemic activity and that there is valid pharmacological basis for employing them for this purpose in India.
authors.affiliation: Department of Pharmacology and Therapeutics, College of Medicine, University of Nigeria, Enugu.
authors.forename: S
authors.initials: S
authors.lastname: Ghasi
authors.forename: E
authors.initials: E
authors.lastname: Nwobodo
authors.forename: J O
authors.initials: JO
authors.lastname: Ofili
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D004041:Dietary Fats / Q000009:adverse effects*; D006937:Hypercholesterolemia / Q000139:chemically induced; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D001798:Blood Proteins; D004041:Dietary Fats; D010936:Plant Extracts; D012709:Serum Albumin; D002784:Cholesterol