title: [Preparation and certain properties of the liposomal substance 2,4-di(1-methyl-3-hydroxybutyl)deuteroporphyrin-IX].
abstract: A liposome preparation of a porphyrin photosensitizer for photodynamic therapy of tumors (PDT) was obtained. The in vitro efficiency of the photosensitizer was enhanced 2.5-fold through the liposome formulation. The composition and some properties of the new preparation were studied. An algorithm for a complex approach to the prediction of photosensitizer efficiencies by model experiments in vitro was developed. This approach is based on the use of two models: the determination of coefficient of distribution between n-octanol and a phosphate buffer, pH 7.4, and the determination of the cytotoxic effect on the culture of CaOv ovarian adenocarcinoma cells.
authors.affiliation: Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Reshetnikov
authors.forename: I V
authors.initials: IV
authors.lastname: Zhigal'tsev
authors.forename: S N
authors.initials: SN
authors.lastname: Kolomeĭchuk
authors.forename: A P
authors.initials: AP
authors.lastname: Kaplun
authors.forename: V I
authors.initials: VI
authors.lastname: Shvets
authors.forename: O S
authors.initials: OS
authors.lastname: Zhukova
authors.forename: A V
authors.initials: AV
authors.lastname: Karmenian
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.forename: G V
authors.initials: GV
authors.lastname: Ponomarev
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D003905:Deuteroporphyrins / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D010051:Ovarian Neoplasms / Q000473:pathology; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: C403943:2,4-di(1-methyl-3-hydroxybutyl)deuteroporphyrin-IX; D003905:Deuteroporphyrins; D008081:Liposomes; D017319:Photosensitizing Agents