Hypothyroidism in primary hyperoxaluria type 1.
We describe 4 patients, aged 3 months to 23 years, with end-stage renal disease and severe, symptomatic hypothyroidism. All 4 had primary hyperoxaluria type 1 (PH1) with diffuse tissue (kidneys, skeleton, eyes, heart) calcium-oxalate deposition, a condition known as oxalosis. The hypothyroidism responded to thyroid hormone replacement therapy. Clinical hypothyroidism within the framework of PH1/oxalosis was probably caused by thyroid tissue damage from an abundance of calcium oxalate. We recommend that thyroid function be monitored in patients with PH1 and oxalosis.
Frishberg
Y
Y
Division of Pediatric Nephrology, Shaare Zedek Medical Center and Hebrew University, Haddasah Medical School, Jerusalem, Israel.
Feinstein
S
S
Rinat
C
C
Drukker
A
A
D002675:Child, Preschool; D003241:Consanguinity; D005260:Female; D006801:Humans; D006960:Hyperoxaluria, Primary / Q000150:complications* / Q000235:genetics; D007037:Hypothyroidism / Q000188:drug therapy / Q000209:etiology*; D007223:Infant; D008297:Male; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use; D013974:Thyroxine / Q000627:therapeutic use
D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine