Contribution of supraglottal mechanoreceptor afferents to respiratory-related evoked potentials in humans.
We used the global field power (GFP) to estimate the magnitude and timing of activation of the somatosensory cortex by respiratory mechanoreceptor afferents in normal humans in response to brief, negative oral pressure pulses applied at the onset of inspiration. We compared responses before (test) and after insertion of a laryngeal mask airway (LMA) that prevented supraglottal airway receptors from sensing the applied stimulus. Evoked potential responses without supraglottic stimulation were smaller, with delayed or missing features, than those with all receptors stimulated. Supraglottic receptors contribute about one-half of the GFP summed over the 100 ms poststimulus, and subglottal receptors, including those in the larynx, provide a GFP response approximately 38% above baseline. The most obvious difference between test and LMA responses occurred at 55 ms on average, when the LMA GFP lacked activation features seen in the test condition. We conclude that mechanoreceptors above the larynx are responsible for a major portion of the midlatency afferent information arriving at the somatosensory cortex in response to applied pressure pulses.
Daubenspeck
J A
JA
Department of Physiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA. andrew.daubenspeck@dartmouth.edu
Manning
H L
HL
Akay
M
M
D000328:Adult; D000344:Afferent Pathways / Q000502:physiology; D004566:Electrodes; D004576:Electromyography; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D017214:Laryngeal Masks; D007830:Larynx / Q000166:cytology / Q000502:physiology*; D008297:Male; D008406:Masseter Muscle / Q000502:physiology; D008465:Mechanoreceptors / Q000502:physiology*; D008875:Middle Aged; D009475:Neurons, Afferent / Q000502:physiology*; D010812:Physical Stimulation; D011312:Pressure; D012123:Pulmonary Ventilation / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D013997:Time Factors