title: Does indocyanine green accurately measure plasma volume independently of its disappearance rate from plasma in critically ill patients?
abstract: OBJECTIVE
  To determine whether plasma volume determined by the indocyanine green (ICG) dilution method (PV-ICG) is equally accurate independently of its disappearance rate from plasma in the critically ill.
  
  
  METHODS
  Retrospective clinical investigation.
  
  
  METHODS
  Intensive care unit of a university teaching hospital.
  
  
  METHODS
  192 adult patients were initially enrolled. The PV-ICG and the initial distribution volume of glucose (IDVG) were calculated utilizing a one-compartment model by simultaneous administration of ICG 25 mg and glucose 5 g on the first day of measurement in each patient. Twenty-one patients were excluded from the study because of a higher PV-ICG/IDVG ratio (> 0.45) indicating apparent overestimation of the PV-ICG associated with the generalized protein capillary leakage. The remaining 171 patients were divided into four groups according to the magnitude of their disappearance rate of ICG from plasma (Ke-ICG).
  
  
  RESULTS
  Convergence was assumed consistently in each ICG or glucose decay curve, even in the lower Ke-ICG less than 0.10/min. The relationship between the two volumes was not statistically different among groups.
  
  
  CONCLUSIONS
  The results suggest that the measurement of the PV-ICG can be equally accurate independently of its disappearance rate from plasma unless there is generalized protein capillary leakage.
authors.affiliation: Department of Anesthesiology, University of Hirosaki School of Medicine, Japan. ishihara@cc.hirosaki-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Iwakawa
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: M
authors.initials: M
authors.lastname: Muraoka
authors.forename: T
authors.initials: T
authors.lastname: Tsubo
authors.forename: A
authors.initials: A
authors.lastname: Matsuki
mesh_terms: D018806:APACHE; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004396:Coloring Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003422:Critical Care; D005260:Female; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D007208:Indocyanine Green / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume / Q000502:physiology*; D012189:Retrospective Studies; D014018:Tissue Distribution
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green; D005947:Glucose