Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms.
Plasma granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-6 (IL-6) concentrations were determined in 21 preterm infants with sepsis and nine healthy preterm neonates of the same postnatal age at sampling. Plasma GM-CSF levels were elevated at diagnosis in the septic preterms as compared to the healthy preterms (P = 0.01), but did not differ significantly on recovery. IL-6 levels were also elevated markedly at diagnosis (P = 0.0003), but decreased to normal on recovery as compared to the healthy preterm infants. GM-CSF levels were more prominent in septic preterms with neutropenia than those of non-neutropenic infants (P = 0.03).


CONCLUSIONS
Preterm infants can produce high levels of granulocyte-macrophage colony-stimulating factor and interleukin-6 in response to bacterial sepsis.
Kantar
M
M
Department of Paediatrics, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey. mkantar@med.ege.edu.tr
Kültürsay
N
N
Kütükçüler
N
N
Akisü
M
M
Cetingül
N
N
Caglayan
S
S
D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007710:Klebsiella Infections / Q000097:blood; D007711:Klebsiella pneumoniae; D018410:Pneumonia, Bacterial / Q000097:blood; D018805:Sepsis / Q000097:blood*
D015850:Interleukin-6; D016178:Granulocyte-Macrophage Colony-Stimulating Factor