Reducing intestinal nematode infection: efficacy of albendazole and mebendazole.
The widespread use of mebendazole and albendazole for treating intestinal nematode infections in human populations is raising concerns that careful monitoring pro- cedures should be in place to identify any emergence of drug resistance. In this article, Andy Bennett and Helen Guyatt discuss whether benchmark parasitological drug efficacy rates can be defined for these anthelmintics, by analysing published data on cure rates and egg reduction rates in the treatment of Ascaris lumbricoides, Trichuris trichiura and hookworm.
Bennett
A
A
Wellcome Trust Centre for the Epidemiology of Infectious Disease (WTCEID), University of Oxford, South Parks Road, Oxford, UK OX1 3FY. andrew.bennett@wellcome-epidemiology.oxford.ac.uk
Guyatt
H
H
D015766:Albendazole / Q000008:administration & dosage / Q000494:pharmacology*; D000722:Ancylostoma / Q000187:drug effects; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology*; D001196:Ascariasis / Q000188:drug therapy*; D017164:Ascaris lumbricoides / Q000187:drug effects; D005243:Feces / Q000469:parasitology; D006725:Hookworm Infections / Q000188:drug therapy*; D006801:Humans; D008463:Mebendazole / Q000008:administration & dosage / Q000494:pharmacology*; D017221:Necator americanus / Q000187:drug effects; D014257:Trichuriasis / Q000188:drug therapy*; D014258:Trichuris / Q000187:drug effects
D000871:Anthelmintics; D008463:Mebendazole; D015766:Albendazole