title: CNS activity of Vitex negundo Linn. in mice.
abstract: Methanolic extract (ME) of the leaves of V. negundo potentiated significantly the sleeping time induced by pentobarbitone sodium, diazepam and chlorpromazine in mice. ME possesses analgesic properties and potentiated analgesia induced by morphine and pethidine. ME also showed significant protection against strychnine and leptazole induced convulsions. The results suggest that ME exhibits CNS depressant activity in a dose dependent manner.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: U K
authors.initials: UK
authors.lastname: Mazumder
authors.forename: S R
authors.initials: SR
authors.lastname: Bhawal
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D051379:Mice; D010147:Pain Measurement; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D012640:Seizures / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects; D020950:Vitex
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D010936:Plant Extracts