Effects of peppermint oil and caraway oil on gastroduodenal motility.
The effect of enteric-coated (Enteroplant) and non-enteric-coated preparations containing a peppermint-caraway oil combination with 90 mg peppermint oil and 50 mg caraway oil was studied on gastroduodenal motility with stationary manometry in six healthy volunteers. The results showed that: (1) both enteric-coated and non-enteric-coated preparations have effects on the migrating motor complex (MMC); (2) mainly a decrease in the number of contractions and contraction amplitudes is seen during the various phases of the MMC; (3) non-enteric-coated preparations have their effects mainly during the first MMC after administration; (4) enteric-coated preparations have their effects temporally delayed during the second MMC after administration. In conclusion, enteric-coated and non-enteric-coated peppermint-caraway oil combinations are safe preparations, acting locally to cause smooth muscle relaxation.
Micklefield
G H
GH
Department of Internal Medicine, Ferdinand-Sauerbruch-Klinikum, University Hospital Witten/Herdecke, Teaching Hospital of the Heinrich-Heine-University/Düsseldorf, Arrenberger Str. 20, 42117 Wuppertal, Germany.
Greving
I
I
May
B
B
D000328:Adult; D018592:Cross-Over Studies; D004386:Duodenum / Q000187:drug effects* / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D036142:Mentha piperita; D010938:Plant Oils / Q000494:pharmacology*; D011446:Prospective Studies; D012016:Reference Values; D029974:Carum
D010938:Plant Oils; C015424:peppermint oil; C104525:caraway oil