Tamoxifen-induced transient multifocal hepatic fatty infiltration.
Tamoxifen is one of the most commonly used anticancer medications. Hepatic damage secondary to tamoxifen treatment is rare. Tamoxifen-induced multifocal hepatic fatty infiltration has not been reported previously. This report describes one case of steatohepatitis caused by tamoxifen in an elderly woman with a history of breast cancer. The patient had multifocal hepatic fatty infiltration secondary to tamoxifen therapy. After tamoxifen was discontinued, the features of multifocal hepatic fatty infiltration on CT improved dramatically, and hepatic transaminases normalized.
Cai
Q
Q
Department of General Internal Medicine, Marshfield Clinic, Wisconsin, USA.
Bensen
M
M
Greene
R
R
Kirchner
J
J
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000000981:diagnostic imaging; D005234:Fatty Liver / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen