Diethylhydroxylamine given in vivo inhibits lipid peroxidation and lipofuscin formation in the nervous tissues of rat.
In vivo effects of diethylhydroxylamine (DEHA) on lipid peroxidation and lipofuscin formation in the nervous tissues of rat have been investigated. Rats were fed DEHA for 30, 60 and 90 days and lipid peroxidation levels and lipofuscin concentration measured in cerebellum, brain stem and spinal cord. Lipofuscin contents were also assessed histochemically. The results showed that the drug caused a significant reduction in lipid peroxidation level and lipofuscin concentration related to ageing.
Sharma
D
D
Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Singh
R
R
D000375:Aging / Q000378:metabolism; D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects* / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D006898:Hydroxylamines / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008062:Lipofuscin / Q000096:biosynthesis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism
D006898:Hydroxylamines; D008062:Lipofuscin; C033314:N,N-diethylhydroxylamine