Impact of nafarelin and leuprolide for endometriosis on quality of life and subjective clinical measures.
OBJECTIVE
To examine the impact of treating endometriosis with nafarelin or leuprolide acetate depot on patient quality of life (QOL) and subjective clinical measures.


METHODS
A randomized, multicenter study was conducted on 192 women with endometriosis. Patients received nafarelin or leuprolide for six months and were followed for up to six months after treatment. QOL was defined by seven items, including symptom severity, daily activities, pain medication use and need for bed rest.


RESULTS
No significant differences were found at baseline between treatments for patients with mild, moderate or no endometriosis symptoms. Those with severe symptoms of endometriosis at baseline and taking nafarelin had a significantly greater improvement in QOL at the last posttreatment visit than those receiving leuprolide (P < .01). Nafarelin was associated with significantly fewer days with moderate or severe hot flashes than leuprolide during treatment (P < .05) and with significantly fewer moderate or severe hypoestrogenic symptoms overall at three months of treatment (P < .05). Additionally, poorer QOL was significantly associated with hypoestrogenic and endometriosis symptoms.


CONCLUSIONS
Treatment of endometriosis with nafarelin was associated with fewer days of moderate or severe hot flashes as compared to leuprolide and with greater improvement in QOL after treatment in patients with severe symptoms at baseline.
Zhao
S Z
SZ
Department of Global Health Outcomes, G.D. Searle & Co., Skokie, Illinois, USA.
Kellerman
L A
LA
Francisco
C A
CA
Wong
J M
JM
D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D001510:Bed Rest; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000627:therapeutic use*; D006728:Hormones / Q000009:adverse effects / Q000627:therapeutic use*; D019584:Hot Flashes / Q000139:chemically induced; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D017274:Nafarelin / Q000009:adverse effects / Q000627:therapeutic use*; D010146:Pain / Q000209:etiology; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000700:Analgesics; D005300:Fertility Agents, Female; D006728:Hormones; D017274:Nafarelin; D016729:Leuprolide