CD95: more than just a death factor?
The CD95 protein delivers crucial signals for lymphocyte death, and may also negatively regulate T-lymphocyte activation by preventing the influx of calcium ions from the cell's exterior. The block in calcium-ion influx occurs through the activation of acidic sphingomyelinase and the release of ceramide, a metabolite that can also induce cell death.
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D020013:Calcium Signaling; D016923:Cell Death; D008213:Lymphocyte Activation; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
D011948:Receptors, Antigen, T-Cell; D019014:fas Receptor