title: Sickle-cell disease not identified by newborn screening because of prior transfusion.
abstract: Erythrocyte transfusion can impair detection of sickle-cell disease, galactosemia, or biotinidase deficiency with newborn screening. We report on 4 infants with SCD in whom delayed diagnosis was associated with neonatal transfusion. In 2 cases, the initial newborn screening showed no hemoglobin S. In no case was the recommended screening >/=120 days from the last transfusion obtained. Two children had significant SCD-related morbidity before diagnosis.
authors.affiliation: Children's Hospital Oakland, Department of Hematology/Oncology, Oakland, CA 94609, USA.
authors.forename: W
authors.initials: W
authors.lastname: Reed
authors.forename: P A
authors.initials: PA
authors.lastname: Lane
authors.forename: F
authors.initials: F
authors.lastname: Lorey
authors.forename: J
authors.initials: J
authors.lastname: Bojanowski
authors.forename: M
authors.initials: M
authors.lastname: Glass
authors.forename: R R
authors.initials: RR
authors.lastname: Louie
authors.forename: B H
authors.initials: BH
authors.lastname: Lubin
authors.forename: E P
authors.initials: EP
authors.lastname: Vichinsky
mesh_terms: D000751:Anemia, Neonatal / Q000628:therapy*; D000755:Anemia, Sickle Cell / Q000175:diagnosis*; D001787:Blood Group Incompatibility / Q000628:therapy*; D002675:Child, Preschool; D017707:Erythrocyte Transfusion; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015997:Neonatal Screening