title: Localization of bcl-2 mRNA in the rabbit central nervous system.
abstract: In this study, we demonstrated bcl-2 expression in the rabbit brain using in situ hybridization and compared the results with the studies done on the other animals. Although the bcl-2 expressions of the rabbit were generally similar to those of the other animals, some differences were also found; the cells in molecular and Purkinje cell layers of the cerebellum, which were bcl-2 negative in the others, showed intense bcl-2 positive signals, while the ependymal cells, arachnoid villi and granular layer, which were positive in the other animals, were not well stained with bcl-2 riboprobes in the rabbit brain. Our findings clearly showed the similarities and differences of rabbit bcl-2 mRNA as compared with the other species for the first time, and provided the basis of further study on the properties of bcl-2 in this species.
authors.affiliation: Department of Anatomy, Dankook University College of Medicine, Chonan, South Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Shin
authors.forename: H Y
authors.initials: HY
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: W J
authors.initials: WJ
authors.lastname: Lee
authors.forename: D H
authors.initials: DH
authors.lastname: Hwang
authors.forename: S H
authors.initials: SH
authors.lastname: Baik
authors.forename: S S
authors.initials: SS
authors.lastname: Cho
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D019254:Genes, bcl-2; D017403:In Situ Hybridization; D009419:Nerve Tissue Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis*; D011817:Rabbits / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity
chemical_list: D009419:Nerve Tissue Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger