Wet and dry interfaces: the role of solvent in protein-protein and protein-DNA recognition.
Water molecules are found in abundance in protein-protein and protein-DNA interfaces. Although interface solvent molecules exchange quickly with the bulk solvent, structural and biochemical data suggest that water-mediated interactions are as important as direct hydrogen bonds in the stability and specificity of recognition.
Janin
J
J
Laboratoire d'Enzymologie et Biochimie Structurales, UPR 9063-CNRS, Gif-sur-Yvette, France. janin@lebs.cnrs-gif.fr
D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D006860:Hydrogen Bonding; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D014867:Water
D011506:Proteins; D014867:Water; D004247:DNA