Treatment of refractory complex-partial status epilepticus with propofol: case report.
OBJECTIVE
We report a case of a 65-year-old woman who had a subarachnoid and intraventricular hemorrhage secondary to rupture of an anterior communicating artery aneurysm and developed nonconvulsive status epilepticus of the complex-partial type, refractory to phenytoin (PHT), phenobarbital (PB), valproate (VPA), and lorazepam (LZP).


METHODS
Three weeks after diagnosis of nonconvulsive status epilepticus, general anesthesia was induced with propofol and titrated to burst suppression on the electroencephalogram (EEG).


RESULTS
During propofol infusion, the serum VPA level declined markedly, and despite >3 g daily doses, did not return to the therapeutic range, until several days after propofol was discontinued. Continuous propofol infusion was stopped after 7 days, and the patient recovered consciousness. Despite further complications, she gradually regained normal function and was discharged home 4 months after surgery.


CONCLUSIONS
This is the first case of nonconvulsive status epilepticus successfully treated with propofol.
Begemann
M
M
Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Rowan
A J
AJ
Tuhrim
S
S
D000368:Aged; D000927:Anticonvulsants / Q000097:blood / Q000627:therapeutic use*; D004347:Drug Interactions; D018432:Drug Resistance, Multiple; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D015742:Propofol / Q000097:blood / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use*
D000927:Anticonvulsants; D014635:Valproic Acid; D015742:Propofol