Absolute measurements of water content using magnetic resonance imaging: preliminary findings in an in vivo focal ischemic rat model.
Using a magnetic resonance (MR) imaging method, absolute measurements of in vivo brain water content were obtained in 15 male Long Evans rats that underwent a 90-min focal cerebral ischemia. A strong linear relationship (r = 0.80) with a slope of 1 was observed when correlating MR-measured water content to that obtained with the ex vivo wet/dry measurements. This effective spin-density-based method is the first-reported in vivo absolute quantification of brain tissue water content associated with a pathophysiological state and preliminary findings suggest that a noninvasive measurement of brain water content can be obtained with MRI.
Venkatesan
R
R
Department of Radiology, Washington University, St. Louis, Missouri, USA.
Lin
W
W
Gurleyik
K
K
He
Y Y
YY
Paczynski
R P
RP
Powers
W J
WJ
Hsu
C Y
CY
D000818:Animals; D001834:Body Water / Q000737:chemistry*; D001929:Brain Edema / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D004195:Disease Models, Animal; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D011336:Probability; D051381:Rats; D020318:Rats, Long-Evans