Sydenham's chorea: MRI and proton spectroscopy.
We present the MRI and proton spectroscopy findings in a child with clinical diagnosis of Sydenham's chorea. MRI showed high signal in the caudate nuclei and putamina on T2-weighted images. We believe that the spectra showed an abnormality in the number and/or function of neurons, lipids from cellular breakdown (cytolytic effect of antibodies), aminoacids (related to the presence of antibodies in the neostriatum), and sugars (also related to the presence of antibodies). The spectroscopy features correlate well with the histopathology and biochemistry of this rare disorder.
Castillo
M
M
Department of Radiology, University of North Carolina School of Medicine, Chapel Hill 27599-7510, USA. castillo@med.unc.edu
Kwock
L
L
Arbelaez
A
A
D001479:Basal Ganglia / Q000473:pathology; D002421:Caudate Nucleus / Q000473:pathology; D002648:Child; D002819:Chorea / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D011699:Putamen / Q000473:pathology