Long-term treatment of portosystemic encephalopathy with oral branched-chain amino acids--a case report.
We treated a 68-year-old male patient of hepatic encephalopathy with oral branched chain amino acids-enriched formula (Aminoleban EN) in addition to lactulose. His encephalopathy was successfully controlled with this therapy for more than a year despite the high blood ammonia levels. Repeated amino acids analyses demonstrated that the deranged branched chain to aromatic amino acids ratio was attenuated with long-term Aminoleban EN administration both in plasma and in cerebrospinal fluid. Oral branched-chain amino acid supplement was very useful in improving the chronic portosystemic or hepatic encephalopathy in this patient.
Fukuda
K
K
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
Yao
H
H
Murai
K
K
Ibayashi
S
S
Fujishima
M
M
D000284:Administration, Oral; D000596:Amino Acids / Q000134:cerebrospinal fluid; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage*; D000641:Ammonia / Q000097:blood; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002908:Chronic Disease; D017809:Fatal Outcome; D006501:Hepatic Encephalopathy / Q000134:cerebrospinal fluid / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D015415:Biomarkers; D000641:Ammonia