title: Conjunctival edema and alopecia of the external third of the eyebrows in a patient with Meige syndrome.
abstract: OBJECTIVE
  To describe a patient with Meige syndrome in whom we observed the coexistence of hereditary lymphedema of the lower legs, conjunctival edema and alopecia of the lateral third of the eyebrows.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  Histological examination of the conjunctival and skin specimens showed dermal edema and a slight reduction in the number of severely ectatic lymphatics in the reticular dermis. The vessel were identified as lymphatics on the basis of immunohistochemical evidence of discontinuity and/or absence of basement membrane.
  
  
  CONCLUSIONS
  Clinical and histological findings suggest that the etiopathogenesis of the edema in Meige syndrome is related to a structural ectatic defect of lymphatics. This anomaly seems to involve both skin and other sites, such as conjunctival mucosa.
authors.affiliation: Department of Dermatology, University of Siena, Policlinico "Le Scotte", I-53100 Siena, Italy. derm@unisi.it
authors.forename: P
authors.initials: P
authors.lastname: Rubegni
authors.forename: M
authors.initials: M
authors.lastname: Fimiani
authors.forename: G M
authors.initials: GM
authors.lastname: Tosi
authors.forename: G
authors.initials: G
authors.lastname: De Aloe
authors.forename: C
authors.initials: C
authors.lastname: Miracco
authors.forename: L
authors.initials: L
authors.lastname: Andreassi
mesh_terms: D000328:Adult; D000505:Alopecia / Q000150:complications* / Q000473:pathology; D001706:Biopsy; D003229:Conjunctival Diseases / Q000150:complications* / Q000473:pathology; D004487:Edema / Q000150:complications* / Q000473:pathology; D005138:Eyebrows; D006801:Humans; D008208:Lymphatic System / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008538:Meige Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography