[Tiagabine and non-convulsive status epilepticus].
A case report is given to draw attention to the risk of the occurrence of nonconvulsive status epilepticus (NCSE) under the anticonvulsant tiagabine in higher doses and doses increases. The patient who had no previous history of status epilepticus developed several NCSE shortly after administration of tiagabine. This represents strong evidence of a causal relationship. Also, in experimental studies it has been shown that in higher doses a disequilibrium between glial and neuronal GABA uptake may aggravate the failure of GABA inhibition thus explaining this adverse side-effect.
Holtkamp
M
M
Neurologische Klinik und Poliklinik, Universitätsklinikum Charité, Humboldt-Universität zu Berlin.
Pfeiffer
M
M
Buchheim
K
K
Meierkord
H
H
D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000513:Alpha Rhythm / Q000187:drug effects; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D001611:Beta Rhythm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D013226:Status Epilepticus / Q000139:chemically induced* / Q000175:diagnosis; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine