[Modification of mouse resistance to A/Aichi/2/68 influenza virus by a glucocorticoid immunosuppressant kenalog].
Changes in the virulence of influenza virus A/Aichi/2/68 LD50 were studied in albino mice with immunosuppression induced by long-acting glucocorticoid kenalog (Kn). In high doses (5 and 10 micrograms/g) Kn induced a decrease in the adrenal, thymic, and splenic weight, which is typical of steroid immunosuppression. The susceptibility of mice preinjected with Kn to the virus increased more than ten-fold, judging by a decrease in LD50. The detected shifts may be due to disorders in lung tissue resistance and reactivity of alveolar macrophages and neutrophils observed previously in induced glucocorticism.
Shishkina
L N
LN
Sergeev
A N
AN
P'iankova
O G
OG
Bulychev
L G
LG
Petrishchenko
V A
VA
Shishkin
A V
AV
Buriak
G A
GA
Bocharov
E F
EF
Zhukov
V A
VA
D000818:Animals; D004198:Disease Susceptibility / Q000276:immunology*; D005938:Glucocorticoids / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009980:Influenza A virus / Q000276:immunology*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D014222:Triamcinolone Acetonide / Q000494:pharmacology*
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide