title: Improvement in severe insulin resistance with frequent injections of lispro insulin.
abstract: Extreme insulin resistance is common in obese African Americans with type 2 diabetes. This case report describes an obese African-American woman who was treated with subcutaneous injections of lispro insulin every 2 hours with resultant decrease of mean daily blood glucose from 264.7 mg/dL to 111 mg/dL and in insulin requirement from 479 U/24 hours to 60 U/24 hours. This case demonstrates that extreme insulin resistance is reversible in the short term.
authors.affiliation: Diabetes Control Center, Orangeburg, SC, USA.
authors.forename: C H
authors.initials: CH
authors.lastname: Raine
authors.forename: M J
authors.initials: MJ
authors.lastname: Krzyston
authors.forename: M
authors.initials: M
authors.lastname: Amr
authors.forename: L
authors.initials: L
authors.lastname: Hydrick
mesh_terms: D003920:Diabetes Mellitus / Q000503:physiopathology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D061268:Insulin Lispro; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro