title: Larval toxocariasis and its clinical manifestation in childhood in the Slovak Republic.
abstract: Results are presented of 90 children aged 1-15 years hospitalized with toxocariasis. Blood count analysis and laboratory examination were done by routine clinical laboratory methods. Anti-Toxocara antibodies were detected in the serum of patients using an ELISA method. Demographic analysis of the children's families exposed to the risk of disease allowed estimation of age-specific rates for clinical toxocariasis. The probability of toxocaral infection and the intensity of its clinical manifestations in children are determined by the epidemiology of this zoonosis and by the risk factors in the family. The presence of high titres of specific IgG antibodies in all age categories correlates with the clinical manifestations of toxocariasis. The highest admission rate is in the age categories of 3-5 years (43.3%) and 6-10 years (36.7%). Laboratory findings show that the most conspicuous changes occur in the age category 1-5 years. The high percentage of seropositive dog-keeping and puppy-breeding families and the possibility of infection with repeated doses of larvae stimulate eosinophilia, which prevails in children under the age of five years. We present the percentage of patients whose parameters showed deviations from the reference values for a particular age category. Analyses of laboratory indices and of clinical manifestations will contribute to the accuracy of diagnosis and effectiveness of treatment of this disease.
authors.affiliation: Parasitological Institute of the Slovak Academy of Sciences, Kosice, Slovak Republic. pausav@saske.sk
authors.forename: J
authors.initials: J
authors.lastname: Kinceková
authors.forename: K
authors.initials: K
authors.lastname: Reiterová
authors.forename: P
authors.initials: P
authors.lastname: Dubinský
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007816:Larva Migrans, Visceral / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008297:Male; D012307:Risk Factors; D018154:Slovakia / Q000453:epidemiology; D014119:Toxocara / Q000276:immunology
chemical_list: D000909:Antibodies, Helminth; D007074:Immunoglobulin G