Acute hepatitis B after autologous stem cell transplantation in a man previously infected by hepatitis B virus.
We report a case of acute hepatitis B after autologous stem cell transplantation (ASCT) in a patient with low-grade non-Hodgkin's lymphoma. At diagnosis of the hematological disease, the patient had the characteristic serology of a previous hepatitis B infection, being Ag HBs negative, hepatitis B virus core antibody positive (anti-HBC) and hepatitis B virus surface antibody weakly positive. He developed fatal hepatitis B after autologous stem cell transplantation, suggesting reactivation consequent to immunosuppression.
Senecal
D
D
Department of Hematology, CHU Bretonneau, Tours, France.
Pichon
E
E
Dubois
F
F
Delain
M
M
Linassier
C
C
Colombat
P
P
D000208:Acute Disease; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006509:Hepatitis B / Q000209:etiology* / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000097:blood; D006511:Hepatitis B Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous / Q000009:adverse effects
D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens