In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae).
The crude extract from the bark and seeds of Khaya grandifoliola was active in vitro against Plasmodium falciparum with an IC50 value of 13.23 microg/ml. The extract was purified to obtain seven limonoids--methylangolensate (1), 6-methylhydroxyangolensate (2), gedunin (3), 7-deacetylkhivorin (5), 1-deacetylkhivorin (6), swietenolide (7), 6-acetylswietenolide (8)--and one flavonoid, catechin (4). Five limonoids (1, 3, 5, 6, 8) were active with IC50 values between 1.25 and 9.63 microg/ml. Catechin was practically devoid of activity. The most active limonoid, gedunin, exhibited an additive effect when combined with chloroquine.
Bickii
J
J
Institut de Recherche pour le Développement (ORSTOM) and Laboratoire de Recherche sur le Paludisme, Laboratoire Associé Francophone 302, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale, Yaoundé, Cameroon.
Njifutie
N
N
Foyere
J A
JA
Basco
L K
LK
Ringwald
P
P
D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology*; D002392:Catechin / Q000302:isolation & purification / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D036701:Limonins; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D012632:Secosteroids / Q000302:isolation & purification / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry
D000962:Antimalarials; D005419:Flavonoids; D036701:Limonins; D010936:Plant Extracts; D012632:Secosteroids; C106014:gedunin; D002738:Chloroquine; D002392:Catechin