[The effect of x-ray contrast media on the concentration of intracellular calcium in mononuclear cells].
It was shown by the method of fluorescent probes that iodine-containing radiocontrast agents Triombrast > Omnipaque > Ultravist > Melitrast increase the content of intracellular Ca2+ in macrophages of the abdominal cavity of rats. Increase in the entry of Ca2+ from the external environment is the main factor of the change in the intracellular concentration of Ca2+ ions in the macrophages in interaction with radiocontrast agents.
Shabunin
I V
IV
Department of Molecular Pharmacology and Radiobiology, Russian State Medical University, Moscow, Russia.
Shimanovskiĭ
N L
NL
Panov
V O
VO
Kalinina
A A
AA
Sviridov
N K
NK
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003287:Contrast Media / Q000494:pharmacology*; D005456:Fluorescent Dyes; D016257:Fura-2 / Q000031:analogs & derivatives; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D018709:Statistics, Nonparametric
D003287:Contrast Media; D005456:Fluorescent Dyes; C049925:fura-2-am; D002118:Calcium; D016257:Fura-2