title: Effects of intramuscular injection of alpha-tocopheryl acetate on fatty acid profile in lamb liver.
abstract: The effects of intramuscularly administrated vitamin E on total lipids, fatty acid profile, and lipid stability to oxidation was investigated in lamb liver. Twenty-four 5-day-old lambs were allotted to 4 groups of 6 each and given respectively 0 (control), 125, 200, 300 mg dl-alpha-tocopheryl acetate weekly from day 5 to 33. alpha-Tocopherol stored in lamb liver at the end of experiment showed linear correlation with the level of injected vitamin E. No effect on total lipids was found. A decrease in the level of liver thiobarbituric-acid reactive substances (TBARS), significantly correlated with liver alpha-tocopherol content, was found in vitamin E groups. The amount of linoleic and linolenic acids significantly increased in the vitamin E groups as compared to control group, and were correlated with the liver alpha-tocopherol content. TBARS were negatively correlated with the concentration of unsaturated fatty acids. Finally, in the liver of the treated groups, vitamin E concentrations in the range 30-50 micrograms/g showed adequate for an efficient protection from peroxidation of membrane lipids, and determined an increase in the unsaturated to saturated fatty acid ratio.
authors.affiliation: Dipartimento di Scienze Animali Vegetali e dell'Ambiente, Università degli Studi del Molise, Campobasso, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Oriani
authors.forename: G
authors.initials: G
authors.lastname: Salvatori
authors.forename: G
authors.initials: G
authors.lastname: Maiorano
authors.forename: A
authors.initials: A
authors.lastname: Manchisi
authors.forename: A
authors.initials: A
authors.lastname: Brienza
authors.forename: L
authors.initials: L
authors.lastname: Pantaleo
authors.forename: R
authors.initials: R
authors.lastname: Di Caterina
authors.forename: T
authors.initials: T
authors.lastname: Rotunno
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D007273:Injections, Intramuscular; D019787:Linoleic Acid / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D012756:Sheep / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017962:alpha-Linolenic Acid / Q000378:metabolism; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D005227:Fatty Acids; D017392:Thiobarbituric Acid Reactive Substances; D017962:alpha-Linolenic Acid; D014810:Vitamin E; D019787:Linoleic Acid; D024502:alpha-Tocopherol; D024505:Tocopherols