Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.
High levels of resistance to challenge with human immunodeficiency virus type 1 SF162 were observed in animals engrafted with peripheral blood mononuclear cells of four long-term nonprogressors (LTNPs). Resistance was abrogated by depletion of CD8(+) T cells in vivo and was observed only in LTNPs with proliferative responses to p24. In a subgroup of nonprogressors, CD8(+) T cells mediated restriction of challenge viruses, and this response was associated with strong proliferative responses to p24 antigen.
de Quiros
J C
JC
Servicio de Medicina Interna 1, Clinica Puerta de Hierro, Universidad Autonoma de Madrid, and Servicio de Microbiologia, Hospital General Gregorio Maranon, Madrid, Spain.
Shupert
W L
WL
McNeil
A C
AC
Gea-Banacloche
J C
JC
Flanigan
M
M
Savage
A
A
Martino
L
L
Weiskopf
E E
EE
Imamichi
H
H
Zhang
Y M
YM
Adelsburger
J
J
Stevens
R
R
Murphy
P M
PM
Zimmerman
P A
PA
Hallahan
C W
CW
Davey
R T
RT
Connors
M
M
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002455:Cell Division; D017690:Cell Transplantation; D018450:Disease Progression; D016655:HIV Core Protein p24 / Q000276:immunology*; D015658:HIV Infections / Q000097:blood / Q000276:immunology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000637:transplantation / Q000821:virology; D008297:Male; D051379:Mice; D016513:Mice, SCID; D014779:Virus Replication
D016655:HIV Core Protein p24