Regulating actin-filament dynamics in vivo.
The assembly and disassembly (i.e. turnover) of actin filaments in response to extracellular signals underlie a wide variety of basic cellular processes such as cell division, endocytosis and motility. The bulk turnover of subunits is 100-200 times faster in cells than with pure actin, suggesting a complex regulation in vivo. Significant progress has been made recently in identifying and clarifying the roles of several cellular proteins that coordinately regulate actin-filament turnover.
Chen
H
H
Department of Biochemistry and Molecular Biology, and the Molecular, Cellular, and Integrative Neuroscience Program, Colorado State University, Fort Collins, CO 80523, USA.
Bernstein
B W
BW
Bamburg
J R
JR
D008841:Actin Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D051339:Actin Depolymerizing Factors; D000199:Actins / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006801:Humans; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D013947:Thymosin / Q000378:metabolism
D051339:Actin Depolymerizing Factors; D000199:Actins; D008840:Microfilament Proteins; D013947:Thymosin; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate