Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy.
We wish to report the detection of dimethyl sulfone (methylsulfonylmethane, C2H6O2S) in the brain of a normal 62-year-old male using in vivo proton magnetic resonance spectroscopy. The presence of this exogenous metabolite resulted from ingestion of a dietary supplement containing dimethyl sulfone. The concentration of this compound in the brain was measured to be 2.4 mmol, with a washout "half life" of approximately 7.5 days. The in vivo T1 and T2 relaxation times of dimethyl sulfone were measured to be 2180 ms and 385 ms, respectively. The concentration of major brain metabolites, namely N-acetylaspartate, total Creatine and Choline, and myo-Inositol were within normal limits.
Rose
S E
SE
Centre for Magnetic Resonance, University of Queensland, St. Lucia, Brisbane, Australia. Stephen.Rose@cmr.uq.edu.au
Chalk
J B
JB
Galloway
G J
GJ
Doddrell
D M
DM
D001921:Brain / Q000378:metabolism*; D019587:Dietary Supplements / Q000032:analysis; D004121:Dimethyl Sulfoxide; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D013450:Sulfones / Q000032:analysis* / Q000493:pharmacokinetics
D013450:Sulfones; C025910:dimethyl sulfone; D004121:Dimethyl Sulfoxide