title: Is CREB a key to neuronal survival?
abstract: A range of molecules control nerve-cell survival in the brain. Many of these molecules might be neuroprotective through activation of the transcription factor cAMP-response-element-binding protein (CREB). Activation of CREB, by phosphorylation of Ser133, occurs in brain-damage-resistant hippocampal dentate granule cells and is triggered by neuroprotective environmental stimulation. In addition, the Akt neuroprotective signaling pathway activates CREB, and CREB synthesis and phosphorylation promote the survival of many cells, including neurons, in vitro. Thus, CREB might be responsible for programmed nerve-cell survival. Studies investigating its role in the brain are now required to confirm these in vitro results, and the downstream survival genes, whose expression is activated by CREB in neurons, need to be identified.
authors.affiliation: Dept of Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: M R
authors.initials: MR
authors.lastname: Walton
authors.forename: I
authors.initials: I
authors.lastname: Dragunow
mesh_terms: D000818:Animals; D002470:Cell Survival; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006133:Growth Substances / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D010766:Phosphorylation
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D006133:Growth Substances