Cyclooxygenases in reproductive medicine and biology.
This review focuses on the role of cyclooxygenases in reproductive medicine and biology. The cyclooxygenase enzymes catalysis the role-limiting reactions for prostaglandins and thromboxane synthesis. Two separate isoforms, COX-1 and COX-2, are present, and differences in their roles are discussed in the context of inflammation and parturition.
Kniss
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Department of Obstetrics and Gynecology, Ohio State University, College of Medicine and Public Health, Columbus 43210, USA. kniss.1@osu.edu
D000818:Animals; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005938:Glucocorticoids / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000502:physiology*; D007743:Labor, Obstetric / Q000502:physiology; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000502:physiology*; D012098:Reproduction
D005938:Glucocorticoids; D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse