title: Are elevated levels of soluble ICAM-1 a marker of chronic graft disease in heart transplant recipients?
abstract: Positivity for circulating intercellular adhesion molecule-1 (ICAM-1) in heart transplant recipients has been claimed to predict the development of coronary artery disease and risk of graft failure. Soluble ICAM-1 were evaluated in 32 heart transplant recipients. Five of these patients, who had undergone transplantation several years before, were positive for soluble ICAM-1 but did not present any clinical sign of graft rejection. Furthermore, although heart graft coronary disease was diagnosed in 15 of the 32 patients, they did not show significantly higher titres of soluble ICAM-1 compared to the remaining patients. These findings suggest that major caution is necessary when considering ICAM-1 positivity as a marker of graft disease.
authors.affiliation: Instituto II Clinica Medica, Endocrinologia, Università degli Studi di Roma 'La Sapienza', Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Campana
authors.forename: C
authors.initials: C
authors.lastname: Parlapiano
authors.forename: M C
authors.initials: MC
authors.lastname: Borgia
authors.forename: U
authors.initials: U
authors.lastname: Papalia
authors.forename: A
authors.initials: A
authors.lastname: Laurenti
authors.forename: P
authors.initials: P
authors.lastname: Pantone
authors.forename: T
authors.initials: T
authors.lastname: Giovanniello
authors.forename: M
authors.initials: M
authors.lastname: Marangi
authors.forename: S
authors.initials: S
authors.lastname: Sanguigni
mesh_terms: D000328:Adult; D015415:Biomarkers; D002908:Chronic Disease; D003327:Coronary Disease / Q000097:blood*; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012995:Solubility
chemical_list: D015415:Biomarkers; D018799:Intercellular Adhesion Molecule-1