Microwave spectroscopy of myocardial ischemia and infarction. 2. Biophysical reconstruction.
The proposed dielectrical relaxation model of the myocardium in the microwave spectrum has been verified both on test solutions and on normal canine myocardium. Furthermore, the model was utilized to reconstruct the changes in tissue properties (including myocardial bulk resistance and water content) following myocardial acute ischemia and chronic infarction. It was shown that the reconstructed myocardial resistance and water content correlate dynamically with the process of the development of acute myocardial ischemic injury. In chronic cases the reconstructed resistance and water content of infarcted myocardium are significantly different from that of normal myocardium: the resistance is lower and water content is higher than in normal myocardium.
Semenov
S Y
SY
Laser and Applied Technologies Laboratory, Carolinas Heart Institute and Carolinas Medical Center, Charlotte, NC 25803-2861, USA. ssemenov@carolinas.org
Svenson
R H
RH
Bulyshev
A E
AE
Souvorov
A E
AE
Nazarov
A G
AG
Sizov
Y E
YE
Posukh
V G
VG
Pavlovsky
A
A
Tatsis
G P
GP
D000208:Acute Disease; D000818:Animals; D001698:Biomedical Engineering; D055592:Biophysical Phenomena; D001703:Biophysics; D001834:Body Water / Q000378:metabolism; D002908:Chronic Disease; D004285:Dogs; D004594:Electrophysiology; D005260:Female; D008297:Male; D008872:Microwaves; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000473:pathology* / Q000503:physiopathology*; D014054:Tomography / Q000379:methods*