title: [Mutagenicity study of gadobenate dimeglumine formulation (E7155) (3)--Micronucleus test in rat bone marrow cells].
abstract: The mutagenic potential of gadobenate dimeglumine formulation (E7155) was studied by the micronucleus test in rats. Single intraperitoneal injection of E7155 to Sprague Dawley rats at the dose of 5295.2 mg/kg (5 mmol/kg) did not induce any statistically significant increase in the frequency of micronucleate cells in the bone marrow sampled after 18, 42 and 66 hr from time of administration.
authors.affiliation: Department of Developmental Safety Assessment Research, Eisai, Co., Ltd., Gifu, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Toritsuka
authors.forename: H
authors.initials: H
authors.lastname: Daimon
authors.forename: S
authors.initials: S
authors.lastname: Sawada
authors.forename: F
authors.initials: F
authors.lastname: Sagami
authors.forename: P
authors.initials: P
authors.lastname: Tirone
authors.forename: A
authors.initials: A
authors.lastname: Morisetti
authors.forename: S
authors.initials: S
authors.lastname: Bussi
authors.forename: F
authors.initials: F
authors.lastname: Fassio
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects; D003287:Contrast Media / Q000633:toxicity*; D005260:Female; D005682:Gadolinium / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives* / Q000633:toxicity; D015162:Micronucleus Tests; D009942:Organometallic Compounds / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; D005682:Gadolinium