Mapping of two tumor suppressor genes in the pig.
Mutations in the breast cancer 1, early onset (BRCA1) gene confer an increased risk of breast and ovarian cancer in humans. The human MAD (mothers against decapentaplegic, Drosophila) homolog 4 (MADH4) locus is a target for deletion in pancreatic and other cancers. Given the role of the pig in biomedical studies, pig orthologs of BRCA1 and MADH4 were identified and localized in the porcine genome.
Kelly
K A
KA
Department of Animal Science, Iowa State University, Ames 50011, USA.
Larsen
N J
NJ
Marklund
S
S
Rothschild
M F
MF
D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary*; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013552:Swine / Q000235:genetics*