[The action of emoxipin, lithium oxybutyrate and pikamilon on the blood circulation of the ischemic brain].
Acute experiments were conducted on rats under nembutal anesthesia to compare the efficacy of emoxipin with that of lithium oxybutyrate and picamilon in the postischemic period after preventive and therapeutic injections in various doses. Emoxipin proved to be most effective in prevention of postischemic non-restoration of the flow of blood in the brain and in preservation of the autoregulation responses of the cerebral vessels. The possible mechanisms of the effect of the drug are discussed.
Pogorelyĭ
V E
VE
Department of Pharmacology, Pyatigorsk State Pharmaceutic Academy, Russia.
Gaevyĭ
M D
MD
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006706:Homeostasis / Q000187:drug effects; D006885:Hydroxybutyrates / Q000494:pharmacology / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D010847:Picolines / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D010847:Picolines; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid; C022826:lithium hydroxybutyrate; C009820:6-methyl-2-ethyl-3-hydroxypyridine