title: Another brick in the wall.
abstract: The X-ray crystal structure of Mycobacterium tuberculosis antigen 85C elucidates the structural basis of fibronectin binding and catalysis of mycolic acid transfer by this potential drug target.
authors.forename: P J
authors.initials: PJ
authors.lastname: Tonge
mesh_terms: D000217:Acyltransferases; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism*; D001386:Azides / Q000494:pharmacology; D001665:Binding Sites; D020134:Catalytic Domain; D002473:Cell Wall / Q000378:metabolism; D003311:Cord Factors / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000472:pathogenicity; D011487:Protein Conformation; D014199:Trehalose / Q000031:analogs & derivatives / Q000494:pharmacology; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: C106082:6-azido-6-deoxytrehalose; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001386:Azides; D003311:Cord Factors; D005353:Fibronectins; D014199:Trehalose; D000217:Acyltransferases; C119774:antigen 85C, Mycobacterium tuberculosis