[Remnant hyperlipidemia and gene polymorphism].
Remnant lipoproteins are intermediate metabolites of triglyceride-rich lipoproteins, such as chylomicron (CM) and very-low density lipoprotein (VLDL) in the circulation. Several lines of evidence have suggested that remnant lipoproteins are atherogenic. It is well known that some of the inherited dyslipidemias cause remnant hyperlipidemia and are accompanied with marked skin and tendon xanthomas, corneal arcus and premature or accelerated atherosclerosis. Among them, lipid abnormalities, clinical features and gene polymorphism of familial dyslipoproteinemia and hepatic lipase deficiency were reviewed. Even if one has affected alleles associated with these disorders, sometimes abnormal lipid profiles are difficult to reveal in the overnight fasting plasma. So, a tolerance test like a fat overloading may be required to elucidate such abnormalities.
Tada
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Aoto Hospital, Department of Internal Medicine 4, Jikeikai University School of Medicine.
D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics*; D008074:Lipoproteins / Q000097:blood*; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood*
D001053:Apolipoproteins; D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002784:Cholesterol