Effects of acetate or bicarbonate dialysis solutions on serum HDL and HDL subfractions of patients undergoing haemodialysis.
The aim of this study was to compare the effect of acetate- and bicarbonate-containing dialysis solutions (buffers) on serum lipid (triglyceride and total cholesterol) and lipoprotein (LDL, HDL and its subfractions as HDL2 and HDL3', Apolipoprotein A1 and Apolipoprotein B) values in patients undergoing haemodialysis. Lipid concentrations in 16 patients on bicarbonate and in 18 patients on acetate haemodialysis were investigated initially and after four weeks of dialysis treatment. Over four weeks of treatment both acetate and bicarbonate dialysis treatments had no negative effects on either HDL or HDL subfractions, and these buffering systems were indistinguishable from each other. We confirm that HDL is the major factor that is changed in the lipid profile in haemodialysis patients undergoing acetate or bicarbonate dialysis and suggest that the relation between LDL and HDL subfractions may be useful for monitoring the lipid changes in haemodialysis patients at risk of atherogenesis.
Yalçin
A
A
Department of Biochemistry, Faculty of Pharmacy, University of Ege, Izmir, Turkey. yalcina@eczacilik.ege.edu.tr
Kocaoğlu
S
S
Akçiçek
F
F
Ozyer
A
A
D000085:Acetates / Q000494:pharmacology*; D000328:Adult; D001053:Apolipoproteins / Q000097:blood / Q000187:drug effects; D001639:Bicarbonates / Q000494:pharmacology*; D005260:Female; D015312:Hemodialysis Solutions / Q000494:pharmacology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008055:Lipids / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors
D000085:Acetates; D001053:Apolipoproteins; D001639:Bicarbonates; D015312:Hemodialysis Solutions; D008055:Lipids; D008075:Lipoproteins, HDL