Restorative effects of zinc and selenium on nitrergic relaxations impaired by cadmium in the mouse corpus cavernosum.
We investigated whether Cd2+ intake (in drinking water, 15 ppm) for 30 days can affect the nitrergic relaxations of the mouse corpus cavernosum (CC) and whether Zn2+ (25 mg kg(-1) via a stomach tube at 48-h intervals) or sodium selenate (8 microg kg(-1) day(-1) intraperitoneally) has a restorative action on the impairment in the response. Relaxant responses of the CC obtained from Cd2+-treated mice to electrical field stimulation (neurogenic) or acetylcholine (endothelium dependent) were significantly inhibited. A partial restoration was observed in the nitrergic relaxation of the CC obtained from Zn2+- or sodium selenate-co-treated animals. Neither agent exhibited any significant action on the responses of the tissue from control mice. There was no significant difference between Cd2+-treated and control mice in respect of the relaxation amplitude induced by sodium nitroprusside or papaverine. These results suggest that Cd2+ intake may impair the nitrergic relaxation of the mouse CC, and, co-treatment with Zn2+ or sodium selenate may partially improve the nitrergic mechanisms in the tissue.
Göçmen
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Department of Pharmacology, Medical Faculty, Cukurova University, Adana, Turkey.
Kumcu
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EK
Seçilmiş
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A
Uçar
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Dikmen
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Baysal
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F
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D010413:Penis / Q000187:drug effects*; D010656:Phenylephrine / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology*
D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D002104:Cadmium; D009599:Nitroprusside; D010656:Phenylephrine; D010208:Papaverine; D012643:Selenium; D015032:Zinc; D000109:Acetylcholine