Different human papillomavirus genotypes in ano-genital lesions.
In order to verify the frequency and physical state of some viral strains of Human Papillomavirus (HPV) in anogenital lesions, two-hundred and four specimens were studied. HPV/DNA was detected by using non isotopic in situ hybridization method, HPV-DNA was found in 25 lesions. The integrated pattern of HPV types 16/18 was found only in invasive carcinomas, the episomic one in all high risk lesions, never in invasive carcinomas. The low oncogenic risk genotypes 6/11 were detected only in condylomata acuminata, the high oncogenic risk genotypes 16/18 were found not only in cervical intraepithelial and invasive lesions, but also in a condyloma acuminatum. Our findings confirm the importance of the viral genotypes in the evaluation of the risk for malignancy. Therefore, the detection of a high risk viral genotype, independently of its physical state, can evoke the ghost of the malignancy also in a low risk cervical lesion.
Caruso
M L
ML
Department of Pathology, Scientific Institute of Gastroenterology, Castellana Grotte, Bari, Italy.
Valentini
A M
AM
D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000473:pathology; D003218:Condylomata Acuminata / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*