title: Spatial expression of Drosophila glutathione S-transferase-D1 in the alimentary canal is regulated by the overlying visceral mesoderm.
abstract: Regional gene expression within Drosophila gut epithelium is regulated by the homeotic genes expressed in the overlying visceral mesoderm. Here it is reported that Glutathione S-transferase-D1 (Gst-D1) had three distinctive expression domains in the gut epithelia: the inner epithelium of the proventriculus, the anterior border of the hindgut epithelium, and the midgut epithelium. Gst-D1 expression in the midgut epithelium became restricted to the region that later formed the third midgut constriction. This spatial restriction within the midgut epithelium required abdominal-A activity in the overlying visceral mesoderm, suggesting that Gst-D1 will be a useful marker to analyze the mechanism of gene regulation across the mesoderm and endoderm.
authors.affiliation: Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nakamura
authors.forename: I
authors.initials: I
authors.lastname: Yoshizaki
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D004064:Digestive System / Q000196:embryology*; D004330:Drosophila / Q000196:embryology* / Q000201:enzymology; D018507:Gene Expression Regulation, Developmental; D005982:Glutathione Transferase / Q000378:metabolism*; D017403:In Situ Hybridization; D007527:Isoenzymes / Q000378:metabolism
chemical_list: D007527:Isoenzymes; D005982:Glutathione Transferase