Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo.
We have previously found that alcohol extract of Crocus sativus L. (CSE), commonly known as saffron, prevents ethanol-induced inhibition of hippocampal long-term potentiation (LTP). In the present study, CSE (250 mg/kg, p.o.) was also effective in preventing acetaldehyde-induced inhibition of LTP in the dentate gyrus of anesthetized rats. These results suggest that CSE can prevent aversive effects induced by ethanol and its metabolite acetaldehyde.
Abe
K
K
Faculty of Pharmaceutical Sciences, Department of Chemical Pharmacology, University of Tokyo, Japan. kazuhoab@mo1.f.u-tokyo.ac.jp
Sugiura
M
M
Yamaguchi
S
S
Shoyama
Y
Y
Saito
H
H
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D018891:Dentate Gyrus / Q000187:drug effects*; D019668:Liliaceae; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000079:Acetaldehyde