[Melatonin effects on functional activity of platelets in patients with bronchial asthma].
OBJECTIVE
To assess effects of epiphysial hormone melatonin in various dose regimens on ADP-induced aggregation of platelets in patients with bronchial asthma (BA). Correlations with urine levels of 6-sulphatoxymelatonin (6-SOMT), basic melatonin metabolite, were made.


METHODS
Melatonin was given to 17 patients with mild or moderate BA and 16 healthy controls.


RESULTS
BA patients were found to have disorders in circadian rhythm of urine 6-SOMT excretion, lack of correlation between platelet functional activity and elevated nocturnal excretion of 6-SOMT, in vitro platelet activation in response to low-dose melatonin and absence of this reaction to high-dose melatonin.


CONCLUSIONS
It is suggested that melatonin may be involved in genesis of bronchoobstructive syndrome in BA.
Evsiukova
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D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001249:Asthma / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D015415:Biomarkers / Q000652:urine; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000652:urine; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D016896:Treatment Outcome
D000975:Antioxidants; D015415:Biomarkers; C054513:6-sulfatoxymelatonin; D008550:Melatonin