The biologically active iron chelators 2-pyridylcarboxaldehyde isonicotinoylhydrazone, 2-pyridylcarboxaldehyde benzoylhydrazone monohydrate and 2-furaldehyde isonicotinoylhydrazone.
In the crystal structures of the respective title compounds, C12H10N4O, C13H11N3O.H2O and C11H9N3O2, variations in the torsion angles of the aromatic pyridyl and benzoyl groups are observed, and the disposition of the heterocyclic aldehyde is shown to be influenced by the ring size of this group.
Richardson
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DR
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia. bernhardt@chemistry.uq.edu.au
Becker
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E
Bernhardt
P V
PV
D018360:Crystallography, X-Ray; D006835:Hydrazones / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D011725:Pyridines / Q000737:chemistry*
C404194:2-furaldehyde isonicotinoylhydrazone; C404193:2-pyridylcarboxaldehyde benzoylhydrazone; C404192:2-pyridylcarboxaldehyde isonicotinoylhydrazone; D006835:Hydrazones; D007502:Iron Chelating Agents; D008024:Ligands; D011725:Pyridines