title: Glioblastoma causing granulocytosis by secretion of granulocyte-colony-stimulating factor.
abstract: We describe a patient with a glioblastoma multiforme with excessive granulocytosis in the peripheral blood. Shown at both protein and mRNA levels, the tumor produced very high levels of granulocyte-colony-stimulating factor (G-CSF). G-CSF is a growth factor that induces the recruitment of granulocytes. The paraneoplastic phenomenon described here partly mimicked a brain abscess. Production of G-CSF by (brain) tumor cells might be related to the granulocytosis common in malignant disease.
authors.affiliation: Department of Neurology, Leiden University Medical Center, The Netherlands. rhintzen@xs4all.nl
authors.forename: R Q
authors.initials: RQ
authors.lastname: Hintzen
authors.forename: J
authors.initials: J
authors.lastname: Voormolen
authors.forename: P
authors.initials: P
authors.lastname: Sonneveld
authors.forename: S G
authors.initials: SG
authors.lastname: van Duinen
mesh_terms: D000368:Aged; D001922:Brain Abscess / Q000175:diagnosis; D001932:Brain Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007964:Leukocytosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male
chemical_list: D016179:Granulocyte Colony-Stimulating Factor