title: Streptococcus mutans strain N produces a novel low molecular mass non-lantibiotic bacteriocin.
abstract: Streptococcus mutans strain N was shown to have bacteriocin production and immunity characteristics consistent with those of Group I mutacin-producing strains of S. mutans. The bacteriocin mutacin N was purified from agar cultures of S. mutans strain N using XAD andp6 reversed phase chromatography. The molecular mass of mutacin N was 4806 Da and the entire 49 amino acid sequence was determined by N-terminal sequencing. Database searches indicate that mutacin N is a novel bacteriocin, but with some homology to the protein IIC domain of a hypothetical sugar-phosphotransferase enzyme from Acholeplasma florum.
authors.affiliation: Department of Microbiology, University of Otago, Dunedin, New Zealand.
authors.forename: M
authors.initials: M
authors.lastname: Balakrishnan
authors.forename: R S
authors.initials: RS
authors.lastname: Simmonds
authors.forename: A
authors.initials: A
authors.lastname: Carne
authors.forename: J R
authors.initials: JR
authors.lastname: Tagg
mesh_terms: D000595:Amino Acid Sequence; D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003773:Dental Plaque / Q000382:microbiology; D006801:Humans; D008969:Molecular Sequence Data; D010770:Phosphotransferases / Q000235:genetics; D010957:Plasmids / Q000235:genetics; D013295:Streptococcus mutans / Q000235:genetics / Q000378:metabolism*
chemical_list: D001430:Bacteriocins; C404754:mutacin N; D010770:Phosphotransferases