CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis.
Development of the vertebrate central nervous system is thought to be controlled by intricate cell-cell interactions and spatio-temporally regulated gene expressions. The details of these processes are still not fully understood. We have isolated a novel vertebrate gene, CRIM1/Crim1, in human and mouse. Human CRIM1 maps to chromosome 2p21 close to the Spastic Paraplegia 4 locus. Crim1 is expressed in the notochord, somites, floor plate, early motor neurons and interneuron subpopulations within the developing spinal cord. CRIM1 appears to be evolutionarily conserved and encodes a putative transmembrane protein containing an IGF-binding protein motif and multiple cysteine-rich repeats similar to those in the BMP-associating chordin and sog proteins. Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding.
Kolle
G
G
Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia.
Georgas
K
K
Holmes
G P
GP
Little
M H
MH
Yamada
T
T
D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D052004:Bone Morphogenetic Protein Receptors; D001921:Brain / Q000196:embryology; D002889:Chromosomes, Human, Pair 2; D017124:Conserved Sequence; D019143:Evolution, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017403:In Situ Hybridization / Q000379:methods; D007448:Invertebrates; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D011506:Proteins; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D012333:RNA, Messenger; D015183:Restriction Mapping; D017386:Sequence Homology, Amino Acid; D013116:Spinal Cord / Q000196:embryology; D014018:Tissue Distribution; D014714:Vertebrates
C486175:CRIM1 protein, human; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011506:Proteins; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; C074370:cysteine-rich protein, mammalian; D052004:Bone Morphogenetic Protein Receptors