title: Absolute measurements of water content using magnetic resonance imaging: preliminary findings in an in vivo focal ischemic rat model.
abstract: Using a magnetic resonance (MR) imaging method, absolute measurements of in vivo brain water content were obtained in 15 male Long Evans rats that underwent a 90-min focal cerebral ischemia. A strong linear relationship (r = 0.80) with a slope of 1 was observed when correlating MR-measured water content to that obtained with the ex vivo wet/dry measurements. This effective spin-density-based method is the first-reported in vivo absolute quantification of brain tissue water content associated with a pathophysiological state and preliminary findings suggest that a noninvasive measurement of brain water content can be obtained with MRI.
authors.affiliation: Department of Radiology, Washington University, St. Louis, Missouri, USA.
authors.forename: R
authors.initials: R
authors.lastname: Venkatesan
authors.forename: W
authors.initials: W
authors.lastname: Lin
authors.forename: K
authors.initials: K
authors.lastname: Gurleyik
authors.forename: Y Y
authors.initials: YY
authors.lastname: He
authors.forename: R P
authors.initials: RP
authors.lastname: Paczynski
authors.forename: W J
authors.initials: WJ
authors.lastname: Powers
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
mesh_terms: D000818:Animals; D001834:Body Water / Q000737:chemistry*; D001929:Brain Edema / Q000175:diagnosis*; D002545:Brain Ischemia / Q000175:diagnosis*; D004195:Disease Models, Animal; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D011336:Probability; D051381:Rats; D020318:Rats, Long-Evans