Sperm cell mediated transgenesis: a review.
Transgenesis would be greatly streamlined if sperm cells could be used as transgene vectors. Attempts to 'force' sperm cells to take up transgenes may be more worthy of further study than 'autouptake' attempts. However, thorough proof of its effectiveness will be required if sperm cell-mediated gene transfer is to be accepted, given the evolutionary implications associated with the possibility of sperm cells being able to transfer exogenous DNA.
Smith
K R
KR
Division of Molecular & Life Sciences, University of Abertay Dundee, Scotland.
D000818:Animals; D018274:Electroporation; D005822:Genetic Vectors; D006801:Humans; D008297:Male; D013094:Spermatozoa; D019076:Transgenes