Varicella-zoster virus proteins in skin lesions: implications for a novel role of ORF29p in chickenpox.
Skin biopsy samples from varicella-zoster virus (VZV)-infected patients examined by immunohistochemistry demonstrated VZV replication in nonepithelial cell types. ORF29p, a nonstructural nuclear protein, was found in nerves of two of six patients with chickenpox. In tissue culture, ORF29p was secreted by VZV-infected fibroblasts. Extracellular ORF29p can be taken up through endocytosis by human neurons, implying a novel role for this protein in pathogenesis.
Annunziato
P W
PW
Departments of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA. paa5@columbia.edu
Lungu
O
O
Panagiotidis
C
C
Zhang
J H
JH
Silvers
D N
DN
Gershon
A A
AA
Silverstein
S J
SJ
D002478:Cells, Cultured; D002644:Chickenpox / Q000473:pathology / Q000821:virology; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D004705:Endocytosis; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism / Q000821:virology; D006562:Herpes Zoster / Q000473:pathology / Q000821:virology; D014645:Herpesvirus 3, Human / Q000472:pathogenicity; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000821:virology; D012867:Skin / Q000473:pathology / Q000821:virology; D017361:Viral Nonstructural Proteins / Q000378:metabolism / Q000502:physiology*
D004268:DNA-Binding Proteins; D017361:Viral Nonstructural Proteins