title: Meta-analysis and retrospective collaboration: two methods to map oligogenes for atopy and asthma.
abstract: Combination of evidence over samples, each of which is too small to be conclusive, is the central problem in complex inheritance. There are three approaches: meta-analysis, prospective collaboration, and retrospective collaboration. Our experience with the first and last, which are the most cost-effective, is discussed.
authors.affiliation: University of Southampton, Wessex Human Genetics Institute, Southampton General Hospital, UK.
authors.forename: C
authors.initials: C
authors.lastname: Lonjou
authors.forename: A
authors.initials: A
authors.lastname: Collins
authors.forename: S
authors.initials: S
authors.lastname: Ennis
authors.forename: W
authors.initials: W
authors.lastname: Tapper
authors.forename: N E
authors.initials: NE
authors.lastname: Morton
mesh_terms: D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D015201:Meta-Analysis as Topic; D012189:Retrospective Studies