title: Metastatic jejunal VIPoma: beneficial effect of combination therapy with interferon-alpha and 5-fluorouracil.
abstract: The VIPoma syndrome is rare. It is usually caused by a neuroendocrine tumor located in the pancreas. Somatostatin analogs and interferon-a can be helpful in the symptomatic control of the disease, but the efficacy of chemotherapy in metastatic disease is limited. We report the case of a 32-yr-old patient who had a primary intestinal VIPoma with peritoneal carcinomatosis and hepatic metastases. Somatostatin analogs and conventional chemotherapy regimens were not effective on VIPoma syndrome and tumor progression. The combination of 5- fluorouracil and interferon-alpha was associated with a major clinical improvement and tumor regression. Further investigations should evaluate the place of such a combination as a first line treatment for patients with metastatic neuroendocrine tumors.
authors.affiliation: Department of Hepato-gastroenterology, Laennec Hospital, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Cellier
authors.forename: C
authors.initials: C
authors.lastname: Yaghi
authors.forename: E
authors.initials: E
authors.lastname: Cuillerier
authors.forename: N
authors.initials: N
authors.lastname: Siauve
authors.forename: A
authors.initials: A
authors.lastname: Berger
authors.forename: F
authors.initials: F
authors.lastname: Carnot
authors.forename: C
authors.initials: C
authors.lastname: Haddad
authors.forename: J P
authors.initials: JP
authors.lastname: Barbier
authors.forename: B
authors.initials: B
authors.lastname: Landi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D007580:Jejunal Neoplasms / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D008297:Male; D010534:Peritoneal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D014057:Tomography, X-Ray Computed; D003969:Vipoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*
chemical_list: D016898:Interferon-alpha; D005472:Fluorouracil