Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis.
Neurotrophin-3 levels were measured in the cerebrospinal fluid of 35 patients with bacterial meningitis, viral meningitis, or encephalitis by two-site enzyme immunoassay. Elevated cerebrospinal fluid levels of neurotrophin-3 were demonstrated in 8 of 18 patients with bacterial meningitis. Follow-up examination of the eight patients at the convalescent stage showed diminished cerebrospinal fluid levels of neurotrophin-3. In contrast, none of the 17 patients with viral meningitis or encephalitis showed an elevation of neurotrophin-3 levels in cerebrospinal fluid. No relationships were observed between neurotrophin-3 levels and cerebrospinal fluid cell numbers, cerebrospinal fluid protein levels, serum C-reactive protein concentrations, or outcome in bacterial meningitis. Since neurotrophin-3 is involved in the survival of neurons and the modulation of the immune system, neurotrophin-3 could play a neuroprotective or immunomodulatory role in bacterial meningitis.
Mizuno
Y
Y
Department of Pediatric Infectious Disease, Fukuoka Children's Hospital and Medical Center for Infectious Diseases, Japan. YR100265@niftyserve.or.jp
Takada
H
H
Urakami
K
K
Ihara
K
K
Kira
R
R
Suminoe
A
A
Ohga
S
S
Aoki
T
T
Hara
T
T
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003289:Convalescence; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D020933:Neurotrophin 3 / Q000134:cerebrospinal fluid*
D020933:Neurotrophin 3