title: The impact of HLA-A matching in corneal transplantation.
abstract: Previously, we have reported the results of our retrospective study on the effect of HLA class II allele matching on the outcome of corneal transplant. Here, we demonstrate our findings of the study for HLA class I allele matching in the same study subjects. Eighty transplant recipients were typed for HLA-A, and 79 transplant recipients were typed for HLA-B alleles, by PCR-SSOP. The association between HLA class I allele matching and 1-year rejection-free graft survival was evaluated. When a total of 79 transplant recipients were subdivided into groups with matching (one to four alleles matched) and without matching (no allele matched) for HLA class I (HLA-A and -B), a significantly higher rate of 1-year rejection-free graft survival was detected in transplant recipients with matching, compared with those without matching (p=0.0258). We have found that matching for at least one HLA class I allele was more beneficial especially in high-risk transplant recipients (p=0.0076). Also, an analysis of matching for each locus separately, detected that, HLA-A matching was significantly associated with a higher rate of 1-year rejection-free graft survival. Transplant recipients with HLA-A matching (one or two-alleles matched) had significantly higher rejection-free graft survival compared with those without matching (no allele matched), when high- and low-risk groups were analyzed together (p=0.0099). Furthermore, matching for HLA-A allele was significantly beneficial compared with no matching in high-risk transplant recipients (p=0.0154). Nevertheless, no significant effect of HLA-B matching was detected. We conclude that HLA class I, especially HLA-A matching has a beneficial effect for corneal transplant outcome.
authors.affiliation: Department of Transplantation Immunology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. munkhbat@is.icc.u-tokai.ac.jp
authors.forename: B
authors.initials: B
authors.lastname: Munkhbat
authors.forename: M
authors.initials: M
authors.lastname: Hagihara
authors.forename: J
authors.initials: J
authors.lastname: Shimazaki
authors.forename: N
authors.initials: N
authors.lastname: Kanai
authors.forename: N
authors.initials: N
authors.lastname: Morita
authors.forename: B
authors.initials: B
authors.lastname: Gansuvd
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Tsubota
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
mesh_terms: D000483:Alleles; D016039:Corneal Transplantation; D006085:Graft Survival; D015234:HLA-A Antigens / Q000235:genetics / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D012189:Retrospective Studies; D014181:Transplantation Immunology
chemical_list: D015234:HLA-A Antigens