Biliary atresia with hyperandrogenic amenorrhea: case report.
The etiology of hyperandrogenic amenorrhea in a 16 year-old girl after a successful Kasai operation for biliary atresia was unclear. Delayed puberty and menarche were observed. There was no luteinizing hormone-follicular stimulating hormone surge. A provocative luteinizing hormone-releasing hormone test showed a normal response. Peripheral aromatization of androgens appeared to function normally. However, plasma levels of sex hormone-binding globulin and total testosterone were high and the free testosterone level was normal. The anovulatory menstrual cycle continued after menarche at 18 years of age. A combination of estrogen and progesterone therapy was effective. The etiology might be associated with delayed metabolic clearance of testosterone accompanied by the compensatory cirrhosis and portosystemic shunt.
Hebiguchi
T
T
Department of Pediatric Surgery, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.
Kato
T
T
Yoshino
H
H
Mizuno
M
M
Takahashi
T
T
Fukuda
J
J
Tanaka
T
T
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D000728:Androgens / Q000097:blood*; D001656:Biliary Atresia / Q000150:complications / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011628:Puberty, Delayed / Q000209:etiology; D013739:Testosterone / Q000097:blood
D000728:Androgens; D013739:Testosterone