title: Pulmonary artery thromboendarterectomy: a comparison of two different postoperative treatment strategies.
abstract: Pulmonary artery thromboendarterectomy (PTE) is a potentially curative surgical procedure for chronic thromboembolic pulmonary hypertension. It is, nevertheless, associated with considerable mortality caused by postoperative complications, such as reperfusion pulmonary edema (RPE) (i.e., pulmonary infiltrates in regions distal to vessels subjected to endarterectomy) and right heart failure (RHF). However, there are no reports about the influence of different postoperative treatment strategies on complications and mortality. Therefore, we compared two different treatment strategies. In Group I (n = 33), positive inotropic catecholamines and vasodilators were avoided during termination of cardiopulmonary bypass (CPB) and thereafter, and mechanical ventilation was performed with low tidal volumes < 8 mL/kg, duration of inspiration:duration of expiration = 3:1, and peak inspiratory pressures < 18 cm H(2)O. In Group II (n = 14), positive inotropic catecholamines and vasodilators were regularly used for termination of CPB and thereafter, and ventilation was performed with high tidal volumes (10-15 mL/kg) and peak inspiratory pressures up to 50 cm H(2)O. Hemodynamics, the incidence of RPE and RHF, duration of ventilation, morbidity, and mortality were recorded. Cardiac index was comparable before surgery (2.11 +/- 0.09 vs 2.08 +/- 0.09 L. min(-1). m(-2)) and 20 min after CPB (2.26 +/- 0.09 vs 2.60 +/- 0.20 L. min(-1). m(-2)). RPE occurred in 6.1% (Group I) versus 14.3% (Group II), and RHF was observed in 9.1% (Group I) versus 21.4% (Group II). Mortality was 9.1% (Group I) versus 21.4% (Group II). Thus, the avoidance of positive inotropic catecholamines and vasodilators in combination with nonaggressive mechanical ventilation after PTE was associated with a low incidence of RPE, RHF, duration of ventilation, and mortality after PTE.
  
  
  CONCLUSIONS
  The avoidance of positive inotropic catecholamines and vasodilators in combination with nonaggressive mechanical ventilation was associated with a low incidence of reperfusion pulmonary edema and/or right heart failure after pulmonary artery thromboendarterectomy.
authors.affiliation: Department Cardiothoracic Anesthesia and Intensive Care, University of Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Mares
authors.forename: T B
authors.initials: TB
authors.lastname: Gilbert
authors.forename: E M
authors.initials: EM
authors.lastname: Tschernko
authors.forename: M
authors.initials: M
authors.lastname: Hiesmayr
authors.forename: M
authors.initials: M
authors.lastname: Muhm
authors.forename: A
authors.initials: A
authors.lastname: Herneth
authors.forename: S
authors.initials: S
authors.lastname: Taghavi
authors.forename: W
authors.initials: W
authors.lastname: Klepetko
authors.forename: I
authors.initials: I
authors.lastname: Lang
authors.forename: W
authors.initials: W
authors.lastname: Haider
mesh_terms: D000328:Adult; D000368:Aged; D001469:Barotrauma / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control; D002303:Cardiac Output, Low / Q000000981:diagnostic imaging / Q000517:prevention & control; D002395:Catecholamines / Q000627:therapeutic use; D002908:Chronic Disease; D004691:Endarterectomy / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011651:Pulmonary Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D011654:Pulmonary Edema / Q000000981:diagnostic imaging / Q000517:prevention & control; D011859:Radiography; D015427:Reperfusion Injury / Q000000981:diagnostic imaging / Q000517:prevention & control; D012121:Respiration, Artificial; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D014655:Vascular Resistance; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D002395:Catecholamines; D014665:Vasodilator Agents