title: Changes in portal venous hemodynamics in patients with severe acute hepatitis over one year.
abstract: OBJECTIVE
  A wide range of portal vein blood flow velocity (PVV) values can be found in acute hepatitis. We studied course and medical significance of PVV changes in patients with severe acute hepatitis over a 1-year period.
  
  
  METHODS
  Portal venous hemodynamics were studied by Doppler sonography in 90 patients at study enrollment and 3, 6, and 12 months following an episode of severe acute hepatitis.
  
  
  RESULTS
  Forty-one survivors who had a maximum PVV at enrollment greater than or equal to the value measured at the third month were classified as the "declining PVV" group. Thirty-six survivors who had a maximum PVV at enrollment less than the value measured at the third month were classified as the "rising PVV" group. Thirteen patients died of acute hepatic failure and were classified as the fatality group. The fatality group had significantly lower maximum PVV, worse liver biochemical test results, and a higher prevalence of ascites at enrollment. In contrast, the declining PVV group showed significantly better liver biochemical test results and a lower prevalence of ascites. There was no significant difference in portal vein blood flow between the rising and declining PVV groups since portal vein diameter increased while PVV decreased.
  
  
  CONCLUSIONS
  An initially decreased PVV can be found in some patients with severe acute hepatitis and is inversely correlated with the severity of liver damage.
authors.affiliation: Liver Unit, Chang Gung Memorial Hospital, Kaohsiung Medical Center, 123, Ta-Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan.
authors.forename: D I
authors.initials: DI
authors.lastname: Tai
authors.forename: C S
authors.initials: CS
authors.lastname: Changchien
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Huang
authors.forename: S K
authors.initials: SK
authors.lastname: Lo
authors.forename: C H
authors.initials: CH
authors.lastname: Kuo
mesh_terms: D000208:Acute Disease; D000328:Adult; D001783:Blood Flow Velocity; D005260:Female; D006439:Hemodynamics; D006525:Hepatitis, Viral, Human / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018608:Ultrasonography, Doppler