Differential sorting and post-secretory targeting of proteins in parasitic invasion.
Toxoplasma gondii uses a highly coordinated arsenal of three structurally and biochemically distinct secretory granules to invade and develop in a wide range of host cells. Proteins of these secretory granules are sorted to strategic subcellular locations using distinctive sorting signals and are then triggered differentially for exocytosis. These secreted proteins are subsequently targeted and inserted into membrane domains.
Ngô
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HM
Dept of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8022, USA.
Hoppe
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HC
Joiner
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D000818:Animals; D016782:Apicomplexa; D003594:Cytoplasmic Granules; D006790:Host-Parasite Interactions; D006801:Humans; D021382:Protein Sorting Signals; D015800:Protozoan Proteins / Q000378:metabolism*; D014122:Toxoplasma / Q000378:metabolism / Q000502:physiology*; D014123:Toxoplasmosis / Q000378:metabolism
D021382:Protein Sorting Signals; D015800:Protozoan Proteins