Distribution of the receptor EphA7 and its ligands in development of the mouse nervous system.
EphA7 is a receptor tyrosine kinase of the Eph family. We have mapped EphA7 immunoreactivity and ligand binding in mouse embryo heads and developing brain. Immunoreactivity for the full-length receptor is found in all the cell populations that express EphA7 mRNA. In particular, it is located on growing axons from EphA7-expressing neurons, both in the trigeminal nerve and in developing brain. In many cases it persists in terminal fields in adult brain. Ligand is detected in a largely complementary distribution in embryos, but is surprisingly weak or undetectable in the target regions of many EphA7-positive axons postnatally.
Rogers
J H
JH
Department of Physiology, University of Cambridge, Downing St., Cambridge, UK. jr@mole.bio.cam.ac.uk
Ciossek
T
T
Ullrich
A
A
West
E
E
Hoare
M
M
Muir
E M
EM
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D004622:Embryo, Mammalian / Q000201:enzymology; D018507:Gene Expression Regulation, Developmental; D015971:Gene Expression Regulation, Enzymologic; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008024:Ligands; D051379:Mice; D009420:Nervous System / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D012333:RNA, Messenger / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D036141:Receptor, EphA7; D013116:Spinal Cord / Q000196:embryology / Q000201:enzymology / Q000254:growth & development; D014018:Tissue Distribution
D008024:Ligands; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases; D036141:Receptor, EphA7