title: Three-dimensional tomographic reconstruction of an absorptive perturbation with diffuse photon density waves.
abstract: A three-dimensional tomographic reconstruction algorithm for an absorptive perturbation in tissue is derived. The input consists of multiple two-dimensional projected views of tissue that is backilluminated with diffuse photon density waves. The algorithm is based on a generalization of the projection-slice theorem and consists of depth estimation, image deconvolution, filtering, and backprojection. The formalism provides estimates of the number of views necessary to achieve a given spatial resolution in the reconstruction. The algorithm is demonstrated with data simulated to mimic the absorption of a contrast agent in human tissue. The effects of noise and uncertainties in the depth estimate are explored.
authors.affiliation: Spectral Sciences, Inc., Burlington, Massachusetts 01803-5169, USA. matt@spectral.com
authors.forename: M
authors.initials: M
authors.lastname: Braunstein
authors.forename: R Y
authors.initials: RY
authors.lastname: Levine
mesh_terms: D000042:Absorption; D000465:Algorithms; D003198:Computer Simulation; D003287:Contrast Media / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008962:Models, Theoretical; D017785:Photons; D014054:Tomography
chemical_list: D003287:Contrast Media