title: A new major triterpene saponin from the roots of Cucurbita foetidissima.
abstract: Foetidissimoside B (1), a novel triterpene saponin, was isolated from the roots of Cucurbita foetidissima. Based on spectroscopic data, especially direct and long-range heteronuclear 2D NMR analysis and on chemical transformations, the structure of 1 was elucidated as 3-O-beta-D-glucuronopyranosyl-echinocystic acid 28-O-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl(1-->3)-[beta- D-xylopyranosyl (1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside . Compound 1 did not show any ability to potentiate in vitro cisplatin cytotoxicity in a human colon cancer cell line.
authors.affiliation: Laboratoire de Pharmacognosie, Unité MIB, Faculté de Pharmacie, Université de Bourgogne, 7 Bd Jeanne d'Arc, 21033 Dijon Cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Gaidi
authors.forename: A
authors.initials: A
authors.lastname: Marouf
authors.forename: B
authors.initials: B
authors.lastname: Hanquet
authors.forename: R
authors.initials: R
authors.lastname: Bauer
authors.forename: M
authors.initials: M
authors.lastname: Correia
authors.forename: B
authors.initials: B
authors.lastname: Chauffert
authors.forename: M A
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D019662:Cucurbitaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D012503:Saponins; C404715:foetidissimoside B; D009828:Oleanolic Acid