Organ-specific immune responses associated with infectious disease.
The immune response to infection can vary markedly in different organs of the same animal. In some organs, the infection can resolve with subsequent immunity to re-infection, whereas in other organs, pathogens can persist. Here, Christian Engwerda and Paul Kaye highlight the importance of defining organ-specific immune mechanisms for developing strategies that deal effectively with infectious diseases and their associated pathologies.
Engwerda
C R
CR
Dept of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT. c.engwerda@lshtm.ac.uk
Kaye
P M
PM
D000818:Animals; D018450:Disease Progression; D007249:Inflammation; D007694:Killer Cells, Natural / Q000502:physiology; D007893:Leishmania donovani / Q000472:pathogenicity; D018314:Leishmania infantum / Q000472:pathogenicity; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D051379:Mice; D009928:Organ Specificity / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000469:parasitology; D013601:T-Lymphocytes / Q000502:physiology; D014781:Viscera / Q000276:immunology* / Q000469:parasitology* / Q000473:pathology