[Drug-induced urinary calculi in 1999].
Drug-induced urolithiasis are observed in 1.6% of the urinary calculi in France. Drugs crystals are identified in two thirds of these stones. Other drugs are responsible for stones which have an apparent metabolic origin (one third of the cases). Stone analysis using physical methods such as infrared spectroscopy is needed to unambiguously identify stones containing drugs. The inquiry is an important step to identify lithogenetic drugs which do not crystallize in the stones. The main substances which were identified in stones over the past decade were indinavir monohydrate (31.4%), triamterene (11.1%), sulphonamides (10.5%) and amorphous silica (4.5%). The main drugs involved in the nucleation and growth of metabolic stones were calcium and vitamin D supplementation (15%) and long-term treatment with carbonic anhydrase inhibitors (8%). Stone prevention is based on drug withdrawal or change in dosage with additional measures including an increase of diuresis and, if necessary, changes in the urine pH.
Daudon
M
M
Laboratoire de Biochimie A, Hôpital Necker-Enfants Malades, Paris, France.
D000086:Acetazolamide / Q000378:metabolism; D000493:Allopurinol / Q000009:adverse effects; D000536:Aluminum Hydroxide / Q000009:adverse effects; D002118:Calcium / Q000378:metabolism; D002400:Cathartics / Q000009:adverse effects; D004232:Diuretics / Q000032:analysis; D017320:HIV Protease Inhibitors / Q000032:analysis; D006801:Humans; D019469:Indinavir / Q000032:analysis; D011736:Pyridoxine / Q000031:analogs & derivatives / Q000378:metabolism; D017640:Silicates / Q000032:analysis; D013449:Sulfonamides / Q000032:analysis; D014223:Triamterene / Q000032:analysis; D014545:Urinary Calculi / Q000139:chemically induced* / Q000737:chemistry / Q000175:diagnosis / Q000453:epidemiology; D014807:Vitamin D / Q000378:metabolism
D002400:Cathartics; D004232:Diuretics; D017320:HIV Protease Inhibitors; D017640:Silicates; D013449:Sulfonamides; D014807:Vitamin D; C001310:pyridoxilate; D000536:Aluminum Hydroxide; D019469:Indinavir; D000493:Allopurinol; D011736:Pyridoxine; D000086:Acetazolamide; D002118:Calcium; D014223:Triamterene