Proinsulin and insulin responses to a mixed meal in hypertriglyceridaemic men.
OBJECTIVE
To investigate the contribution of proinsulin to the "hyperinsulinaemia" of hypertriglyceridaemia.


METHODS
Plasma glucose, triglyceride, immunoreactive insulin, and intact proinsulin concentrations were measured before and after a mixed meal in 11 hypertriglyceridaemic men and six healthy normotriglyceridaemic male controls.


RESULTS
Hypertriglyceridaemic subjects had greater fasting (101 v 50 pmol/l) and integrated (139 v 81 x 0(-3) pmol/l/h) insulin concentrations than controls. Fasting and integrated glucose and proinsulin concentrations were similar in the two groups.


CONCLUSIONS
Proinsulin does not contribute to the hyperinsulinaemia observed in hypertriglyceridaemic subjects and is therefore unlikely to contribute to the increased cardiovascular risk associated with hypertriglyceridaemia.
Gama
R
R
Royal Surrey County Hospital, Guildford, Surrey, UK.
Norris
F
F
Hampton
S
S
Morgan
L
L
Wright
J
J
Marks
V
V
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005502:Food; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D011384:Proinsulin