Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans.
The calcineurin gene was cloned and disrupted in serotype D strains of Cryptococcus neoformans. Serotype A and serotype D calcineurin mutants were inviable at 37 degrees C and avirulent in mice, whereas only serotype A mutants were cation stress sensitive. Thus, calcineurin plays conserved and divergent roles in serotype A and serotype D strains.
Cruz
M C
MC
Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Sia
R A
RA
Olson
M
M
Cox
G M
GM
Heitman
J
J
D000818:Animals; D001483:Base Sequence; D019703:Calcineurin / Q000235:genetics / Q000502:physiology*; D003455:Cryptococcus neoformans / Q000145:classification / Q000254:growth & development / Q000472:pathogenicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009154:Mutation; D012703:Serotyping; D014774:Virulence
D019703:Calcineurin