Conjunctival lymphocytic infiltrates associated with Epstein-Barr virus.
OBJECTIVE
To describe the clinicopathologic features of two patients with Epstein-Barr virus (EBV) associated conjunctival lymphocytic infiltrates.


METHODS
Two case reports.


METHODS
The clinical histories and pathologic findings of two patients with salmon-colored conjunctival infiltrates are described.


METHODS
Clinical observation and pathologic examination of conjunctival biopsy specimens with accompanying immunohistochemical staining, flow cytometric immunophenotyping, and polymerase chain reaction analysis when appropriate.


RESULTS
One patient had ipsilateral preauricular lymphadenopathy, elevated serum EBV titers, and a unilateral reactive lymphocytic infiltrate resulting in a conjunctival mass. The other patient had bilateral conjunctival lymphocytic infiltrates causing conjunctival masses. There was an expanded clonal population of B lymphocytes in the conjunctival mass in the second patient. Both patients had EBV antigen in their conjunctival lymphocytic infiltrates.


CONCLUSIONS
Conjunctival lymphocytic lesions associated with EBV represent a spectrum of reactive infiltrates to monoclonal populations.
Feinberg
A S
AS
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Spraul
C W
CW
Holden
J T
JT
Grossniklaus
H E
HE
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D002648:Child; D003228:Conjunctiva / Q000473:pathology; D003229:Conjunctival Diseases / Q000235:genetics / Q000473:pathology* / Q000821:virology; D015828:Eye Infections, Viral / Q000235:genetics / Q000473:pathology* / Q000821:virology; D005434:Flow Cytometry; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D006566:Herpesviridae Infections / Q000235:genetics / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D008297:Male; D016133:Polymerase Chain Reaction; D019310:Pseudolymphoma / Q000235:genetics / Q000473:pathology* / Q000821:virology; D014412:Tumor Virus Infections / Q000235:genetics / Q000473:pathology* / Q000821:virology
D000956:Antigens, Viral; D007143:Immunoglobulin Heavy Chains