Acute stress does not alter 5-HT1A receptor density.
Previous research suggests that 5-HT1A receptors are altered with exposure to chronic stress. No previous studies have examined the effect of acute stress on 5-HT1A. Using receptor autoradiography it was observed that there were no differences in [3H]-8-OH-DPAT binding between control rats and rats that received 20 minutes of restraint stress 2 hours prior to sacrifice. This study suggests that the changes in 5-HT1A receptor density associated with chronic stress develop over the course of repeated stress.
Steciuk
M
M
North Texas Veterans Affairs Medical Center, Dallas 75216, USA.
Kram
M
M
Kramer
G L
GL
Petty
F
F
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000378:metabolism; D000208:Acute Disease; D000818:Animals; D001345:Autoradiography; D001923:Brain Chemistry / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010865:Pilot Projects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin