DNA-PCR system FGA (FIBRA)--genotype and allele frequencies in a sample of western Germany (Düsseldorf region).
Frequency data for the STR system FGA (HumFibra) were obtained from a Caucasoid German population sample (Düsseldorf area) of 424 unrelated individuals. PCR products were detected by horizontal polyacrylamid gel electrophoresis and a total of 16 alleles was identified by side-by-side comparison with a commercially available sequenced ladder. The observed genotype distribution showed no significant deviation from the Hardy-Weinberg equilibrium. The high information content (pooled German data: rate of heterozygosity = 0.8626; probability of match = 0.0344; mean exclusion chance = 0.7240) render this system a useful tool not only in forensic casework (criminal and paternity cases) but in population genetics too.
Huckenbeck
W
W
Institute for Forensic Medicine, Düsseldorf, Germany.
Scheil
H G
HG
Kuntze
K
K
D004247:DNA / Q000235:genetics*; D005340:Fibrinogen / Q000235:genetics; D005787:Gene Frequency; D005828:Genetics, Population; D005858:Germany / Q000453:epidemiology; D006801:Humans; D010641:Phenotype; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences
D005340:Fibrinogen; D004247:DNA