Chemical carcinogenicity: can it be predicted from knowledge of mutagenicity and allergic contact dermatitis?
We investigated the suggestion [R.E. Albert, Environ. Health Perspect. 105 (1997) 940-948.] that results of mutagenicity testing in Salmonella combined with allergic contact dermatitis (ACD) testing in humans would be predictive of carcinogenicity in rodents. Using the cancer bioassay results of the US National Toxicology Program (NTP), Salmonella mutagenicity tests and a highly predictive structure-activity relational model of ACD, we conclude that the combination is not more predictive than the results of the Salmonella mutagenicity assay alone.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA. rsnkranz@pitt.edu
Karol
M H
MH
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D017449:Dermatitis, Allergic Contact; D006801:Humans; D009152:Mutagenicity Tests; D011237:Predictive Value of Tests; D012377:Rodentia; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D012984:Software; D013329:Structure-Activity Relationship
D002273:Carcinogens