title: [The presenilin mystery. The research winner-by-a knockout?].
authors.affiliation: IPMC du CNRS, UPR411, Sophia-Antipolis, Valbonne, France. checler@ipmc.cnrs.fr
authors.forename: F
authors.initials: F
authors.lastname: Checler
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D005799:Genes, Dominant; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000378:metabolism; D053764:Presenilin-1; D053766:Presenilin-2; D053763:Presenilins; D046988:Proteasome Endopeptidase Complex; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D029742:Caenorhabditis elegans Proteins; D029721:Drosophila Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D009097:Multienzyme Complexes; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D053763:Presenilins; C106427:Psn protein, Drosophila; C095907:SEL-12 protein, C elegans; D014452:Ubiquitins; C505407:CASP3 protein, human; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex