Changes in serum diamine oxidase activity during chemotherapy in patients with hematological malignancies.
Serum diamine oxidase (DAO) activity is very low, but is considered to reflect quantitative changes in small intestinal mass. Therefore, we measured DAO activity during chemotherapy in patients with hematological malignancies in order to evaluate mucosal injury. DAO activity decreased from 1-3 weeks after chemotherapy but returned to initial levels after 4 weeks. As the dosage of anti-cancer drugs increased, DAO activity decreased more, but its activity was not related to other parameters. These findings suggest that serum DAO could be used as an indicator of mucosal injury during chemotherapy.
Tsujikawa
T
T
The Second Department of Internal Medicine, Shiga University of Medical Science, Tsukinowa, Otsu, Japan.
Uda
K
K
Ihara
T
T
Inoue
T
T
Andoh
A
A
Fujiyama
Y
Y
Bamba
T
T
D000328:Adult; D000368:Aged; D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001798:Blood Proteins / Q000378:metabolism; D016026:Bone Marrow Transplantation; D002802:Cholinesterases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000201:enzymology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology; D007938:Leukemia / Q000188:drug therapy / Q000201:enzymology; D007958:Leukocyte Count / Q000187:drug effects; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
D001798:Blood Proteins; D012709:Serum Albumin; D006631:Amine Oxidase (Copper-Containing); D002802:Cholinesterases