title: Contractures secondary to immobility: is the restriction articular or muscular? An experimental longitudinal study in the rat knee.
abstract: OBJECTIVE
  To measure articular structures' contribution to the limitation of range of motion after joint immobility.
  
  
  METHODS
  Experimental, controlled study involving 40 adult rats that had one knee joint immobilized in flexion for durations of 2, 4, 8, 16, and 32 weeks; 20 rats underwent a sham procedure. The angular displacement was measured both in flexion and extension at three different torques. Myotomy of transarticular muscles allowed isolation of the arthrogenic component of the contracture.
  
  
  RESULTS
  A contracture developed in all immobilized knees. The articular structures were incrementally responsible for the limitation in range of motion (from 12.6 degrees +/-6.7 degrees at 2 weeks to 51.4 degrees +/-5.4 degrees at 32 weeks). The myogenic restriction proportionately decreased over time (from 20.1 degrees +/-8.4 degrees at 2 weeks to only 0.8 degrees +/-7.2 degrees at 32 weeks). The increase in the arthrogenic component of contracture was predominant in extension.
  
  
  CONCLUSIONS
  This study quantified the increasing role of arthrogenic changes in limiting the range of motion of joints after immobility, especially as the period of immobility extended past 2 weeks. These data provide a better understanding of joint contracture development and can be used to guide therapeutic approaches.
authors.affiliation: Department of Medicine, University of Ottawa, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Trudel
authors.forename: H K
authors.initials: HK
authors.lastname: Uhthoff
mesh_terms: D000818:Animals; D003286:Contracture / Q000209:etiology / Q000503:physiopathology*; D007103:Immobilization / Q000009:adverse effects*; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D016059:Range of Motion, Articular; D051381:Rats; D017207:Rats, Sprague-Dawley; D019415:Torque