[The characteristics of the distribution of HLA antigens in the families of children with aneuploid chromosomal pathology].
Search of possible immunogenetic markers of tendency to form aneuploid offspring was carried out. We have studied HLA-antigens distribution among families with Down syndrome and Turner syndrome children and among families with miscarriages. The disposition to reproduction of affected offspring is associated with following HLA-antigens: B40, B41 and B51. The most typical haplotypes among families with affected offspring were: A2B27, A2B40, A2B51, A9B51, A10B8, A10B40. The HLA-antigens distribution among families with miscarriages supports evidence, that certain haplotypes can contribute to aneuploidy in progeny.
Terpyliak
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OI
D000026:Abortion, Habitual / Q000235:genetics / Q000276:immunology; D000782:Aneuploidy; D016009:Chi-Square Distribution; D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics* / Q000276:immunology; D025063:Chromosome Disorders; D004314:Down Syndrome / Q000235:genetics / Q000276:immunology; D005260:Female; D005787:Gene Frequency / Q000235:genetics / Q000276:immunology; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D011247:Pregnancy; D014424:Turner Syndrome / Q000235:genetics / Q000276:immunology
D006680:HLA Antigens