title: Tau gene polymorphisms and apolipoprotein E epsilon4 may interact to increase risk for Alzheimer's disease.
abstract: In an effort to analyze the genetic role of tau in Alzheimer's disease (AD), 17 polymorphisms were identified. Eleven of these polymorphisms were in complete linkage disequilibrium and segregated as two haplotypes, A and B. The A and B haplotypes were investigated in 269 AD cases and 238 controls from two different sources, a clinic-based group (mean age of onset 65+/-9 years), and a population-based group (mean age of onset 80+/-5 years). A synergistic effect between the common tau genotype AA and apolipoprotein E (APOE epsilon4) was found in the clinic-based AD group. Our study suggests that the common tau genotype AA may interact with APOE epsilon4 in increasing the risk of AD in a subgroup of the AD population.
authors.affiliation: Karolinska Institutet, Division of Geriatric Medicine, NEUROTEC, Geriatric Medicine, Novum, Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Lilius
authors.forename: S
authors.initials: S
authors.lastname: Froelich Fabre
authors.forename: H
authors.initials: H
authors.lastname: Basun
authors.forename: C
authors.initials: C
authors.lastname: Forsell
authors.forename: K
authors.initials: K
authors.lastname: Axelman
authors.forename: K
authors.initials: K
authors.lastname: Mattila
authors.forename: A
authors.initials: A
authors.lastname: Andreadis
authors.forename: M
authors.initials: M
authors.lastname: Viitanen
authors.forename: B
authors.initials: B
authors.lastname: Winblad
authors.forename: L
authors.initials: L
authors.lastname: Fratiglioni
authors.forename: L
authors.initials: L
authors.lastname: Lannfelt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D016875:tau Proteins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D016875:tau Proteins