Radioimmunodiagnosis and therapy.
Although promising results with radioimmunotherapy and radioimmunodiagnosis in haematological diseases, have been reported, they are less encouraging results in solid tumours. Experimental mathematical models suggest that optimization of antibody-based therapy and diagnosis is possible and that further research towards improvement is warranted. In this review, the major problems of radioimmunotherapy and diagnosis are discussed. Particular items adressed include tumour uptake of antibodies and antibody-fragments, the target/non-target ratio, immunogenicity and the selection of radionuclides.
Verhaar-Langereis
M J
MJ
Department of Internal Medicine/Oncology, University Medical Centre Utrecht, The Netherlands.
Zonnenberg
B A
BA
de Klerk
J M
JM
Blijham
G H
GH
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D016719:Radioimmunodetection / Q000009:adverse effects / Q000379:methods; D016499:Radioimmunotherapy / Q000009:adverse effects / Q000379:methods; D011868:Radioisotopes
D000911:Antibodies, Monoclonal; D011868:Radioisotopes