Hyalodendrosides A and B, antifungal triterpenoid glycosides from a lignicolous hyphomycete, Hyalodendron species.
Two antifungal triterpenoid glycosides, hyalodendrosides A and B (1 and 2), were isolated from a solid matrix fermentation of a lignicolous hyphomycete, Hyalodendron sp. Their structures were determined based upon extensive examination of spectral parameters, particularly NMR and MS data. Both compounds have beta-linked glucose moieties. Compounds 1 and 2 show weak to moderate antifungal activity against some clinically relevant fungi.
Bills
G
G
Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. gerald_bills@merck.com
Dombrowski
A
A
Morris
S A
SA
Hensens
O
O
Liesch
J M
JM
Zink
D L
DL
Onishi
J
J
Meinz
M S
MS
Rosenbach
M
M
Thompson
J R
JR
Schwartz
R E
RE
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002236:Carbohydrate Conformation; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes
D000935:Antifungal Agents; D012503:Saponins; D014315:Triterpenes; C404713:hyalodendroside A; C404714:hyalodendroside B