Oceanapiside, an antifungal bis-alpha,omega-amino alcohol glycoside from the marine sponge Oceanapia phillipensis.
The structure of oceanapiside, an antifungal alpha, omega-bis-aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation/correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 micrograms/mL (MIC).
Nicholas
G M
GM
Department of Chemistry, University of California, Davis 95616, USA.
Hong
T W
TW
Molinski
T F
TF
Lerch
M L
ML
Cancilla
M T
MT
Lebrilla
C B
CB
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification*; D006017:Glycolipids / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D000935:Antifungal Agents; D006017:Glycolipids; C404387:oceanapiside