[Study of monoamino- and amino acidergic mechanisms of the rat caudate nucleus in antiaversive effects of tranquilizers in various anxiety models].
Administration of anxio-sedative drugs into the rat caudate nucleus revealed that antiaversive effects of chlordiazepide, phemibut, and indoter only occur under dominating fear motivation, whereas antiaversive effects of campirone and campironine occur under the influence of negative or stressful zoo-social actions and are realised via the GABA- and serotoninergic type of synaptic switching in the dorsal part of the caudate nucleus.
Talalaenko
A N
AN
Gorky Medical University, Donetsk, Ukraine.
Gordienko
D V
DV
Markova
O P
OP
D000596:Amino Acids / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000188:drug therapy* / Q000378:metabolism; D015306:Biogenic Monoamines / Q000378:metabolism* / Q000494:pharmacology; D002421:Caudate Nucleus / Q000378:metabolism*; D008297:Male; D008845:Microinjections; D017072:Neostriatum; D051381:Rats; D012701:Serotonin / Q000502:physiology; D014149:Tranquilizing Agents / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000596:Amino Acids; D015306:Biogenic Monoamines; D014149:Tranquilizing Agents; D012701:Serotonin; D005680:gamma-Aminobutyric Acid