Seizure and electroencephalographic changes in the newborn period induced by opiates and corrected by naloxone infusion.
OBJECTIVE
To describe the association between opioid administration in the newborn period and neurologic abnormalities.


METHODS
Case reports of two infants who presented with seizure activity and abnormal electroencephalograms associated with opiate administration, and reversed by naloxone.


RESULTS
The first was a preterm infant who developed a burst-suppression pattern on the electroencephalogram while receiving a continuous infusion of morphine and muscle paralysis. Naloxone injection during the electroencephalogram recording reversed the burst-suppression pattern. The second was a term infant receiving fentanyl infusion for pain control following surgery, who presented with motor seizure that was only partially controlled with barbiturates. An abnormal electroencephalogram recording during the opiate infusion improved with naloxone administration.


CONCLUSIONS
Our observations indicate a potential for neurologic abnormalities, including induction of seizure activity and electroencephalogram abnormalities, suggesting caution when opiates are used for sedation and/or pain control in the newborn period.
da Silva
O
O
Department of Pediatrics, University of Western Ontario, Lawson Research Institute, London, Canada.
Alexandrou
D
D
Knoppert
D
D
Young
G B
GB
D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D012640:Seizures / Q000139:chemically induced*
D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine