Molecular characterization of the beta-lactamases from clinical isolates of Moraxella (Branhamella) catarrhalis obtained from 24 U.S. medical centers during 1994-1995 and 1997-1998.
The beta-lactamases from 403 Moraxella (Branhamella) catarrhalis clinical isolates obtained during 1994-1995 and 1997-1998 U.S. multicenter surveillance studies were characterized by isoelectric focusing. The overall prevalences of the BRO-1 and BRO-2 enzymes among beta-lactamase-positive isolates were estimated to be 97.5 and 2.5%, respectively. The minimum inhibitory concentrations (MICs) of ampicillin for all BRO-2-producing isolates were </=1 microg/ml; however, numerous beta-lactamase-positive isolates for which the ampicillin MICs were </=1 microg/ml produced the BRO-1 enzyme (88. 1%).
Richter
S S
SS
Medical Microbiology Division, Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
Winokur
P L
PL
Brueggemann
A B
AB
Huynh
H K
HK
Rhomberg
P R
PR
Wingert
E M
EM
Doern
G V
GV
D006801:Humans; D007525:Isoelectric Focusing; D008826:Microbial Sensitivity Tests; D001936:Moraxella catarrhalis / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification; D015337:Multicenter Studies as Topic; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
D001618:beta-Lactamases