title: Low-molecular-weight heparin for prosthetic heart valves: treatment failure.
abstract: There is no adequate substitute therapy for patients with prosthetic heart valves, in whom anticoagulation with warfarin or unfractionated heparin must be withheld. In the literature there are several reports describing successful treatment with low-molecular-weight heparin in patients with prosthetic heart valves. We report two cases of low-molecular-weight heparin treatment failure resulting in thrombosed prosthetic heart valves with stormy clinical presentations, who underwent successful valve replacements.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Tel-Aviv Sourasky Medical Center, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Lev-Ran
authors.forename: A
authors.initials: A
authors.lastname: Kramer
authors.forename: J
authors.initials: J
authors.lastname: Gurevitch
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: R
authors.initials: R
authors.lastname: Mohr
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001021:Aortic Valve / Q000601:surgery; D000075202:Contraindications; D004452:Echocardiography; D017984:Enoxaparin / Q000627:therapeutic use; D005260:Female; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000000981:diagnostic imaging; D012086:Reoperation; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology; D017211:Treatment Failure; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; D006495:Heparin, Low-Molecular-Weight; D014859:Warfarin