title: Plummer's disease with spontaneous progression to hypothyroidism.
abstract: A case of Plummer's disease that spontaneously progressed to hypothyroidism is presented. A 49-year-old female visited our hospital because of a 3 kg decrease in body weight during the previous month and a painless nodule in the right anterior area of her neck. A diagnosis of Plummer's disease was made based on the results of thyroid function tests, thyroid scintigrams, and an ultrasonogram, but the patient's disease followed an usual clinical course. About two months later, she gradually developed manifestations of permanent hypothyroidism, and anti-thyroid autoantibodies became positive. In spite of continuous administration of levothyroxine sodium, uptake of 99mTcO4- to the nodule was unchanged or rather increased according to the consecutive thyroid scintigraphies. These results suggested that this case represented an autonomously functioning nodule with underlying silent thyroiditis and Hashimoto's disease.
authors.affiliation: Department of Nuclear Medicine, Hyogo College of Medicine, Nishinomiya, Japan. nakae@hyo-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nakae
authors.forename: M
authors.initials: M
authors.lastname: Kawanaka
authors.forename: M
authors.initials: M
authors.lastname: Suehiro
authors.forename: M
authors.initials: M
authors.lastname: Sugita
authors.forename: M
authors.initials: M
authors.lastname: Fukuchi
mesh_terms: D001323:Autoantibodies / Q000097:blood; D018450:Disease Progression; D005260:Female; D006044:Goiter, Nodular / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013670:Sodium Pertechnetate Tc 99m / Q000493:pharmacokinetics; D013962:Thyroid (USP) / Q000627:therapeutic use; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
chemical_list: D001323:Autoantibodies; D019275:Radiopharmaceuticals; D013962:Thyroid (USP); D014284:Triiodothyronine; C052092:Thyradin; D013972:Thyrotropin; D013670:Sodium Pertechnetate Tc 99m; D013974:Thyroxine