Synthesis of 5-imino-5H-dipyrido[1,2-a; 2',3'-d]pyrimidines as potential antiallergy agents (1).
A novel route to 5-imino-5H-dipyrido[1,2-a; 2',3'-d]pyrimidines is described. The method is based on the Ullmann condensation of 2-chloro-3-cyano-5-nitropyridine with 2-amino-pyridine 1-oxides, followed by intramolecular cyclization of the resulting 2-(3-cyano-5-nitro-2-pyridylamino)pyridine 1-oxides with phosphorous trichloride.
Rykowski
A
A
Institute of Chemistry, Agricultural and Pedagogical University, Siedlce, Poland.
Pucko
W
W
D018926:Anti-Allergic Agents / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*
D018926:Anti-Allergic Agents; D011743:Pyrimidines