Meta-analysis and retrospective collaboration: two methods to map oligogenes for atopy and asthma.
Combination of evidence over samples, each of which is too small to be conclusive, is the central problem in complex inheritance. There are three approaches: meta-analysis, prospective collaboration, and retrospective collaboration. Our experience with the first and last, which are the most cost-effective, is discussed.
Lonjou
C
C
University of Southampton, Wessex Human Genetics Institute, Southampton General Hospital, UK.
Collins
A
A
Ennis
S
S
Tapper
W
W
Morton
N E
NE
D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics*; D015201:Meta-Analysis as Topic; D012189:Retrospective Studies