A new major triterpene saponin from the roots of Cucurbita foetidissima.
Foetidissimoside B (1), a novel triterpene saponin, was isolated from the roots of Cucurbita foetidissima. Based on spectroscopic data, especially direct and long-range heteronuclear 2D NMR analysis and on chemical transformations, the structure of 1 was elucidated as 3-O-beta-D-glucuronopyranosyl-echinocystic acid 28-O-beta-D-glucopyranosyl-(1-->3)-beta-D-xylopyranosyl(1-->3)-[beta- D-xylopyranosyl (1-->4)]-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside . Compound 1 did not show any ability to potentiate in vitro cisplatin cytotoxicity in a human colon cancer cell line.
Gaidi
G
G
Laboratoire de Pharmacognosie, Unité MIB, Faculté de Pharmacie, Université de Bourgogne, 7 Bd Jeanne d'Arc, 21033 Dijon Cedex, France.
Marouf
A
A
Hanquet
B
B
Bauer
R
R
Correia
M
M
Chauffert
B
B
Lacaille-Dubois
M A
MA
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D019662:Cucurbitaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
D012503:Saponins; C404715:foetidissimoside B; D009828:Oleanolic Acid