title: Computerized analysis of mammographic parenchymal patterns for breast cancer risk assessment: feature selection.
abstract: Our purpose in this study was to identify computer-extracted, mammographic parenchymal patterns that are associated with breast cancer risk. We extracted 14 features from the central breast region on digitized mammograms to characterize the mammographic parenchymal patterns of women at different risk levels. Two different approaches were employed to relate these mammographic features to breast cancer risk. In one approach, the features were used to distinguish mammographic patterns seen in low-risk women from those who inherited a mutated form of the BRCA1/BRCA2 gene, which confers a very high risk of developing breast cancer. In another approach, the features were related to risk as determined from existing clinical models (Gail and Claus models), which use well-known epidemiological factors such as a woman's age, her family history of breast cancer, reproductive history, etc. Stepwise linear discriminant analysis was employed to identify features that were useful in differentiating between "low-risk" women and BRCA1/BRCA2-mutation carriers. Stepwise linear regression analysis was employed to identify useful features in predicting the risk, as estimated from the Gail and Claus models. Similar computer-extracted mammographic features were identified in the two approaches. Results show that women at high risk tend to have dense breasts and their mammographic patterns tend to be coarse and low in contrast.
authors.affiliation: Department of Radiology, The University of Chicago, Illinois 60637, USA. z-huo@uchicago.edu
authors.forename: Z
authors.initials: Z
authors.lastname: Huo
authors.forename: M L
authors.initials: ML
authors.lastname: Giger
authors.forename: D E
authors.initials: DE
authors.lastname: Wolverton
authors.forename: W
authors.initials: W
authors.lastname: Zhong
authors.forename: S
authors.initials: S
authors.lastname: Cumming
authors.forename: O I
authors.initials: OI
authors.lastname: Olopade
mesh_terms: D024682:BRCA2 Protein; D055592:Biophysical Phenomena; D001703:Biophysics; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D003201:Computers; D016002:Discriminant Analysis; D005260:Female; D019398:Genes, BRCA1; D016147:Genes, Tumor Suppressor; D006801:Humans; D008327:Mammography / Q000379:methods*; D008954:Models, Biological; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D012044:Regression Analysis; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics
chemical_list: D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors