title: Aspergillus osteomyelitis after liver transplantation: conservative or surgical treatment?
abstract: We report on a liver transplant recipient who developed coxarthritis and lumbar spondylodiscitis due to Aspergillus flavus. He was treated with high-dose liposomal amphotericin B for 2 months followed by itraconazole. Because of intractable pain and severe, irreversible damage of the left hip, a Girdlestone resection was performed. The spondylodiscitis was treated successfully with anti-fungal agents only, which indicates that, in the absence of neurological impairment, good clinical outcome can be achieved without surgery. This case demonstrates that surgical therapy, which is often proclaimed as unavoidable for the treatment of Aspergillus osteomyelitis, should be considered in particular in the case of intolerable pain due to irreversible joint damage or involvement of vital organs.
authors.affiliation: Department of Hepatogastroenterology, University Hospital Rotterdam, The Netherlands.
authors.forename: T J
authors.initials: TJ
authors.lastname: Tang
authors.forename: H L
authors.initials: HL
authors.lastname: Janssen
authors.forename: C H
authors.initials: CH
authors.lastname: van der Vlies
authors.forename: R A
authors.initials: RA
authors.lastname: de Man
authors.forename: H J
authors.initials: HJ
authors.lastname: Metselaar
authors.forename: H W
authors.initials: HW
authors.lastname: Tilanus
authors.forename: S
authors.initials: S
authors.lastname: de Marie
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D001231:Aspergillus flavus; D015299:Discitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D016031:Liver Transplantation; D008161:Lumbosacral Region; D008279:Magnetic Resonance Imaging; D008297:Male; D010019:Osteomyelitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D011184:Postoperative Period; D012445:Sacrococcygeal Region