Melatonin reduces quinolinic acid-induced lipid peroxidation in rat brain homogenate.
The protective effects of melatonin against the neurotoxin, quinolinic acid, were investigated in rat brain homogenate using the thiobarbituric acid assay. Quinolinic acid increased lipid peroxidation in a dose dependent manner. When homogenate was cotreated with melatonin there was a significant decrease in lipid peroxidation. The results of the present report show that melatonin may play a protective role in the brain against the neurohormone quinolinic acid, which has been identified as a causative agent in Huntington's Disease.
Southgate
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Department of Biochemistry and Microbiology, Rhodes University, Grahamstown, South Africa. chsd@giraffe.ru.ac.za
Daya
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D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008550:Melatonin / Q000494:pharmacology*; D017378:Quinolinic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D008054:Lipid Peroxides; D008315:Malondialdehyde; D017378:Quinolinic Acid; D008550:Melatonin