Targeting of piperine intercalated in mannose-coated liposomes in experimental leishmaniasis.
The leishmanicidal property of piperine intercalated in liposomes and in mannose-coated liposomes was tested in experimental visceral leishmaniasis in hamsters. Mannose-coated liposomal piperine eliminated intracellular amastigotes of Leishmania donovani in splenic macrophages much more efficiently than did the liposomal piperine or free piperine. At a dose equivalent to 6 mg/kg body wt every 4th day for a total of 4 doses in 12 days, the mannose-coated liposomal piperine was found to reduce spleen parasite load to the extent of 90% in comparison to that achieved by liposomal piperine (77%) or free piperine (29%). Histological examination of spleen and liver function tests showed that the toxicity of piperine was reduced when mannosylated liposomal piperine was administered.
Raay
B
B
Biomembrane Division, Indian Institute of Chemical Biology, Calcutta, India.
Medda
S
S
Mukhopadhyay
S
S
Basu
M K
MK
D000470:Alkaloids; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D052117:Benzodioxoles; D006224:Cricetinae; D004337:Drug Carriers; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000503:physiopathology; D008081:Liposomes; D008111:Liver Function Tests; D008264:Macrophages / Q000469:parasitology; D008358:Mannose / Q000008:administration & dosage; D008647:Mesocricetus; D010880:Piperidines / Q000008:administration & dosage* / Q000627:therapeutic use; D053284:Polyunsaturated Alkamides; D013154:Spleen / Q000469:parasitology / Q000503:physiopathology
D000470:Alkaloids; D000981:Antiprotozoal Agents; D052117:Benzodioxoles; D004337:Drug Carriers; D008081:Liposomes; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D008358:Mannose; C008922:piperine