title: Prosthetic patch remnants to treat infected arterial grafts.
abstract: OBJECTIVE
  Our previous experience with the traditional management of infected prosthetic arterial grafts, which included graft excision and vein patch repair of the involved artery, was complicated by a high incidence of vein patch rupture. This study assessed the treatment of infected prosthetic grafts with subtotal graft excision and oversewing of small graft remnants.
  
  
  METHODS
  During the last 20 years, we treated 53 wounds involving 45 infected prosthetic grafts in 42 patients by means of subtotal graft excision and oversewing of a residual 2- to 3-mm graft remnant (patch) at an intact arterial anastomosis. This technique was selectively used to maintain patency of small-diameter arteries (41 common femoral, five deep femoral, three axillary, two iliac, and two popliteal), which were critical for limb salvage or amputation healing. This strategy avoided difficult dissection of the underlying artery in scarred wounds and obviated the placement of a new patch in an infected field. Graft remnants were polytetrafluoroethylene in 51 cases and Dacron in two cases. Of the 45 grafts, 31 were occluded and 14 were patent. All infected tissue was widely debrided, wet-to-dry dressing changes were performed three times daily, and appropriate intravenous antibiotics were administered for at least 1 week. Secondary bypass grafting procedures were performed as needed to achieve limb salvage. The follow-up period in surviving patients averaged 32 months (range, 1 to 218 months).
  
  
  RESULTS
  No complications were directly attributable to prosthetic patch remnants in 92% of cases (49 of 53 cases). Six of 42 patients (14%) died during hospitalization (three of cardiac complications and three of sepsis with multiple organ failure). Two infected pseudoaneurysms developed 8 and 34 months after surgery, and two wounds failed to heal. Sixteen secondary bypass grafting procedures were necessary to achieve limb salvage. Patch oversewing led to limb salvage without the need for secondary revascularization in 26 other cases and to the successful healing of 10 amputated limbs when secondary revascularization was not possible.
  
  
  CONCLUSIONS
  Prosthetic patch remnants are a useful adjunct that simplify management of infected prosthetic grafts, are associated with a low incidence of wound complications, and help maintain patency of essential collaterals to achieve limb salvage or heal an amputation.
authors.affiliation: Section of Vascular Surgery, Pennsylvania Hospital, and the Division of Vascular Surgery, Montefiore Medical Center, Philadelphia, PA 19106, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Calligaro
authors.forename: F J
authors.initials: FJ
authors.lastname: Veith
authors.forename: J A
authors.initials: JA
authors.lastname: Valladares
authors.forename: J
authors.initials: J
authors.lastname: McKay
authors.forename: N
authors.initials: N
authors.lastname: Schindler
authors.forename: M J
authors.initials: MJ
authors.lastname: Dougherty
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D017024:Chemotherapy, Adjuvant; D005260:Female; D006083:Graft Occlusion, Vascular / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation / Q000379:methods; D016879:Salvage Therapy / Q000379:methods; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000601:surgery*; D013536:Suture Techniques; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents