[The significance of genetic and environmental factors for migraine with aura. A genetic epidemiologic study of Danish twins].
We studied the genetic and environmental influence on migraine with aura (MA) by analysing a twin population. The twin sample consisted of 2,026 monozygotic (MZ) pairs and 3,334 same-gender dizygotic (DZ) pairs recruited from the population-based Danish Twin Register. A total of 211 pairs were identified, of whom 77 were MZ and 134 were DZ. The pairwise concordance rate was significantly higher in MZ-than in DZ-pairs, i.e. 34% and 12%, respectively, emphasizing the importance of genetic factors in MA. However, environmental factors are also important, as the pair wise concordance rate was less than 100% in MZ-pairs. Similarly, the recurrence risk of MA was 50% in MZ- and 21% in DZ-pairs which was a significant difference. In non-twin siblings, the recurrence risk of MA is 27%, which is similar to the recurrence risk in DZ-pairs. This indicates that MA is not developed due to specific environmental factors shared by the twins.
Ulrich
V
V
Neurologisk afdeling, Amtssygehuset i Glostrup.
Gervil
M
M
Kyvik
K O
KO
Olesen
J
J
Russell
M B
MB
D000328:Adult; D003718:Denmark / Q000453:epidemiology; D004200:Diseases in Twins; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D012042:Registries; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic