title: [Hyperkeratosis lenticularis perstans (Flegel's disease) - a complex disorder of epidermal differentiation with good response to a synthetic vitamin D3 derivate].
abstract: Hyperkeratosis lenticularis perstans (Flegel's disease) is a rare but clinically and histologically highly characteristic genodermatosis. We report on new immunohistochemical and ultrastructural findings suggesting a complex disorder of epidermal differentiation. In this context, a good response to calcipotriol, a synthetic vitamin D3 derivative is of particular interest.
authors.affiliation: Univ.-Hautklinik Münster.
authors.forename: D
authors.initials: D
authors.lastname: Metze
authors.forename: D
authors.initials: D
authors.lastname: Lübke
authors.forename: T
authors.initials: T
authors.lastname: Luger
mesh_terms: D000368:Aged; D002117:Calcitriol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004817:Epidermis / Q000473:pathology; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol