title: On the relative sample size required for multiple comparisons.
abstract: Multiple comparisons are commonly made in epidemiologic and genetic research. How to appropriately adjust for multiple comparisons remains a controversial issue. This note demonstrates, however, that large increases in the number of comparisons has a limited effect on the sample size required to maintain an experimentwise alpha-level. In particular, the relative sample size required increases only linearly with the logarithm of the number of comparisons made.
authors.affiliation: Department of Epidemiology and Biostatistics, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland OH 44109-1998, USA. witte@darwin.cwru.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Witte
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
authors.forename: L R
authors.initials: LR
authors.lastname: Cardon
mesh_terms: D015233:Models, Statistical; D012107:Research Design; D018401:Sample Size