title: Effects of indomethacin and hyperventilation on cerebral hemodynamics and oxygenation in newborn piglets.
abstract: We investigated the effect of indomethacin (INDO) and hyperventilation (HV) on cerebral hemodynamics and oxygenation in newborn piglets using near-infrared spectroscopy (NIRS). A total of 10 piglets aged 7-10 days were divided into 2 groups. INDO (Experimental group; 0.2 mg/kg i.v.) or saline (Control group) was administered after steady state, then each group was hyperventilated (pCO2; 20 mm Hg). Cerebral oxyhemoglobin concentrations (HbO2) significantly decreased immediately after INDO administration compared to controls (p < 0.01). This decrease continued for 15 min. During HV, HbO2 remained low compared to the steady state (p < 0.05) in the experimental group. Total hemoglobin concentrations (HbT) decreased simultaneously with HbO2. In the control group, no changes in HbO2 or HbT were observed after saline administration, and only a slight decrease in HbO2 was observed during the 5 minutes' HV compared to the steady state. No changes in cytochrome aa3 (Cytaa3) were observed in either group during 100% O2 inhalation. We conclude that INDO decreased HbO2 and HbT by vasoconstriction, but that HV did not further aggravate this tendency. Great care should be taken when using INDO for newborn neonates.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan. yushiro@med.kurume-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Murakami
authors.forename: N
authors.initials: N
authors.lastname: Wada
authors.forename: A
authors.initials: A
authors.lastname: Togo
authors.forename: T
authors.initials: T
authors.lastname: Matsuishi
authors.forename: H
authors.initials: H
authors.lastname: Kato
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D001921:Brain / Q000502:physiology*; D006439:Hemodynamics; D007213:Indomethacin / Q000494:pharmacology*; D010100:Oxygen / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared; D013552:Swine
chemical_list: D010100:Oxygen; D007213:Indomethacin