title: Combined intraepithelial squamous neoplasia and atypical fibroxanthoma of the cornea and limbus.
abstract: OBJECTIVE
  To investigate a case of an unusual neoplasm of the cornea and limbus.
  
  
  METHODS
  A 59-year-old man presented with a highly vascularized, nodular mass involving the left cornea and limbus. An excisional biopsy and, subsequently, a superficial lamellar keratectomy and multiple conjunctival biopsies were performed. At the 6-month follow-up examination, repeat conjunctival biopsies were performed.
  
  
  RESULTS
  Histopathologic examination of the corneal specimen showed a high-grade intraepithelial squamous neoplasia (in situ carcinoma) overlying an atypical fibroxanthoma.
  
  
  CONCLUSIONS
  We report the clinical and histologic appearance of a corneal/limbal neoplasm consisting of an intraepithelial squamous neoplasia and an atypical fibroxanthoma.
authors.affiliation: Department of Ophthalmology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
authors.forename: N E
authors.initials: NE
authors.lastname: Engelbrecht
authors.forename: J G
authors.initials: JG
authors.lastname: Ford
authors.forename: W L
authors.initials: WL
authors.lastname: White
authors.forename: R P
authors.initials: RP
authors.lastname: Yeatts
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D003316:Corneal Diseases / Q000473:pathology* / Q000601:surgery; D005134:Eye Neoplasms / Q000473:pathology* / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016850:Limbus Corneae / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery