Antiplatelets activity of some xanthone derivatives.
The effects of twelve aminoalkanolic derivatives of xanthone on platelet aggregation have been evaluated. Five from them inhibited thrombin-induced platelet aggregation. The most active compound was R-(+)-2-N-(7-chloro-2-xanthonemethyl)-2-N-methylamino-1-butanol [IV] which, at a concentration of 40 micrograms/ml, nearly completely inhibited the aggregation concentration (TAC) of thrombin.
Rajtar
G
G
Department of Pharmacology and Toxicology, Medical University School, Lublin, Poland.
Zółkowska
D
D
Kleinrok
Z
Z
Marona
H
H
D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000494:pharmacology
D010975:Platelet Aggregation Inhibitors; D013917:Thrombin