title: Inverse relation between prostate-specific antigen and insulin-like growth factor-binding protein 3 in bone metastases and serum of patients with prostate cancer.
abstract: The usual osteoblastic phenotype of metastatic prostate cancer is unexplained. Here we show that tissue and serum concentrations of prostate-specific antigen (PSA)-vary inversely with a substrate protein that binds a growth factor known to activate osteoblasts. These findings suggest that PSA may contribute to the osteoblastic phenotype, and could thus represent a new drug target devoid of antiandrogenic toxicity.
authors.forename: G L
authors.initials: GL
authors.lastname: Smith
authors.forename: A P
authors.initials: AP
authors.lastname: Doherty
authors.forename: H
authors.initials: H
authors.lastname: Mitchell
authors.forename: I W
authors.initials: IW
authors.lastname: Hanham
authors.forename: T J
authors.initials: TJ
authors.lastname: Christmas
authors.forename: R J
authors.initials: RJ
authors.lastname: Epstein
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000097:blood / Q000175:diagnosis / Q000556:secondary*; D001842:Bone and Bones / Q000473:pathology; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; D018972:Insulin-Like Growth Factor Binding Protein 3; D017430:Prostate-Specific Antigen