title: Effects of traditional versus delayed resuscitation on serum lactate and base deficit.
abstract: OBJECTIVE
  To test the hypothesis that delayed resuscitation of hemorrhagic shock produces a less severe shock insult than traditional resuscitation, characterized by repeated episodes of alternating hypotension and normotension.
  
  
  METHODS
  Female pigs were divided into three groups. Sham operated controls (C) (n = 4), sustained hypotension (SS) (n = 6), and hypotension with multiple cycles of shock and resuscitation (SR) (n = 6). SS and SR animals were bled to a mean arterial pressure (MAP) of 50 mmHg. SS animals were maintained at an MAP of 50 mmHg for 65 min and then resuscitated to baseline blood pressure with normal saline and shed blood. SR animals were initially bled and maintained at an MAP of 50 mmHg for 35 min, resuscitated to baseline BP, and subsequently bled and resuscitated twice more. The total period of shock was the same in both SS and SR.
  
  
  RESULTS
  Following hemorrhage, there was a significant increase in lactate and base deficit in SS as compared to C and SR.
  
  
  CONCLUSIONS
  Delayed resuscitation produces a more profound shock insult than traditional resuscitation.
authors.affiliation: Department of Emergency Medicine, SUNY Health Science Center at Brooklyn, New York, NY 11203, USA. bonny1@msn.com
authors.forename: B J
authors.initials: BJ
authors.lastname: Baron
authors.forename: R H
authors.initials: RH
authors.lastname: Sinert
authors.forename: A K
authors.initials: AK
authors.lastname: Sinha
authors.forename: M C
authors.initials: MC
authors.lastname: Buckley
authors.forename: G W
authors.initials: GW
authors.lastname: Shaftan
authors.forename: T M
authors.initials: TM
authors.lastname: Scalea
mesh_terms: D000818:Animals; D001794:Blood Pressure; D005260:Female; D019344:Lactic Acid / Q000097:blood*; D012151:Resuscitation / Q000379:methods*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000628:therapy*; D013552:Swine; D013997:Time Factors
chemical_list: D019344:Lactic Acid