Ivermectin treatment of mansonellosis in Trinidad.
This study was conducted to determine the efficacy and long-term effects of an intervention programme based on a single dose of Ivermectin (6 mg) administered during a double-blind placebo study of 40 persons with Mansonella ozzardi infections in Blanchisseuse, Trinidad. After four years, ivermectin reduced microfilariae levels by 82.2%. Short- and long-term effectiveness of the drug is contingent upon the initial microfilariae levels of the patient. We conclude that a single dose of ivermectin reduces microfilariae densities and provides both short- and long-term reductions in M ozzardi microfilaraemia.
Gonzalez
A A
AA
Tulane University Medical Center, School of Public Health and Tropical Medicine, New Orleans LA, USA.
Chadee
D D
DD
Rawlins
S C
SC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005369:Filaricides / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007559:Ivermectin / Q000008:administration & dosage*; D008297:Male; D008368:Mansonelliasis / Q000188:drug therapy*; D008875:Middle Aged; D018512:Parasitemia / Q000188:drug therapy*; D014300:Trinidad and Tobago
D005369:Filaricides; D007559:Ivermectin