title: [Angiotensin II inhibits L-type voltage-dependent Ca(2+)-current in smooth muscle cells from the rat aorta].
abstract: Macroscopic voltage-activated L-type Ca2+ currents were blocked by angiotensin II (A11), the effect being inhibited by losartan. A rise in internal Ca2+ evoked by the A11, occurred, losartan being ineffective in these cases. The AT1 receptors seem to be involved in the effect of the A11 on the L-type Ca2+ current in aortic smooth muscle cells.
authors.affiliation: Cardiological Research-Industrial Complex, Moscow, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Serebriakov
authors.forename: K
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000502:physiology; D020746:Calcium Channels, L-Type / Q000502:physiology*; D020747:Calcium Channels, T-Type / Q000502:physiology; D002478:Cells, Cultured; D004558:Electric Stimulation; D004594:Electrophysiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D020746:Calcium Channels, L-Type; D020747:Calcium Channels, T-Type; D014662:Vasoconstrictor Agents; D000804:Angiotensin II