Likelihood of undergoing genetic testing for cancer risk: a population-based study.
BACKGROUND
Studies on public perceptions of genetic susceptibility testing for cancer risks are few and tend to focus on specific cancer risks of higher-risk populations, ignoring the general population and their perceived risk of getting any cancers. This study develops and tests a psychosocial model of the proximal and distal influences on likelihood of undergoing genetic susceptibility testing for cancer risk among a population-based sample.


METHODS
The sample consisted of 622 adults aged 18-75 interviewed by telephone. The survey instrument included measures derived from the Health Belief Model and adaptations of existing measures from the literature. Data were analyzed using structural equation modeling techniques.


RESULTS
The model suggested independent main effects for perceived benefits, perceived barriers, perceived susceptibility, and pessimism while simultaneously accounting for the effects of age, socioeconomic status, family history of cancer, and awareness of the existence of genetic susceptibility testing for cancer risk. The model explained 34% of the variance in likelihood.


CONCLUSIONS
While perceived benefits, perceived barriers, perceived susceptibility, and pessimism may directly impact likelihood, they may also mediate the effects of age, socioeconomic status, family history of cancer, and awareness of cancer genetic susceptibility testing, on likelihood.
Bosompra
K
K
Department of Medical Biostatistics, University of Vermont, Burlington,Vermont 05405, USA. kwadwo.bosompra@uvm.edu
Flynn
B S
BS
Ashikaga
T
T
Rairikar
C J
CJ
Worden
J K
JK
Solomon
L J
LJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D018672:Community Health Planning; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D015438:Health Behavior; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control*; D009518:New York