Blood perfusion of subcutaneous tumours in mice following the application of low-level direct electric current.
Electrotherapy with low-level direct electric current has been proved to be an effective local treatment of solid tumours. In the presented study an attempt was made to evaluate the effect of a single treatment with electrotherapy on blood perfusion of solid subcutaneous fibrosarcoma Sa-1 tumours in A/J mice. The tissue-staining method with Patent blue-violet dye, the rubidium extraction technique, and the noninvasive near-infrared spectroscopy method were used for this purpose. Results of all methods indicate that perfusion and subsequently oxygenation of tumours were reduced due to application of electrotherapy.
Jarm
T
T
Faculty of Electrical Engineering, University of Ljubljana, Slovenia.
Wickramasinghe
Y A
YA
Deakin
M
M
Cemazar
M
M
Elder
J
J
Rolfe
P
P
Sersa
G
G
Miklavcic
D
D
D000818:Animals; D004396:Coloring Agents; D004599:Electric Stimulation Therapy / Q000379:methods; D005260:Female; D005354:Fibrosarcoma / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D012394:Rosaniline Dyes; D012413:Rubidium; D012878:Skin Neoplasms / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D019265:Spectroscopy, Near-Infrared; D013194:Staining and Labeling / Q000379:methods
D004396:Coloring Agents; D012394:Rosaniline Dyes; C008769:sulfan blue; D012413:Rubidium