title: The Angio-Seal hemostatic puncture closure device. Concept and experimental results.
abstract: The Angio-Seal hemostatic puncture closure device is the culmination of development efforts dating from 1986. Development was driven to solve problems of delivering a multi-piece bioabsorbable puncture closure assembly through an introducer, the precise placement of the device in the vessel, the mastery of molding tiny absorbable polymer components, the manufacture of collagen hemostatic sponges having strong tear strength, and the testing of very large samples to establish safety and efficacy. Improvements included in the new 6F device to improve deployment reliability are also discussed.
authors.affiliation: Kensey Nash Corporation (KNC), Exton, Pennsylvania, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Nash
authors.forename: D G
authors.initials: DG
authors.lastname: Evans
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002404:Catheterization / Q000295:instrumentation*; D002986:Clinical Trials as Topic; D003094:Collagen; D016503:Drug Delivery Systems / Q000295:instrumentation; D006489:Hemostatic Techniques / Q000295:instrumentation*; D006801:Humans; D010330:Patents as Topic; D011108:Polymers; D011677:Punctures / Q000295:instrumentation*; D012449:Safety; D013537:Sutures; D013552:Swine; D013997:Time Factors; D014481:United States
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D003094:Collagen