title: Severe pulmonary disease in association with Crohn's disease in a 13-year-old girl.
abstract: Pulmonary manifestations of Crohn's disease are infrequent in adults and even less common in children. Our literature search found only a few cases of Crohn's disease causing pulmonary manifestations in children. We report on the case of a 13-year-old girl in whom severe pulmonary disease was found four years after the onset of Crohn's disease. Open lung biopsy uncovered bronchiolitis obliterans and granulomatous lung disease. Aggressive treatment has yielded gradual improvement. This case emphasizes the importance of recognizing the association, the differential diagnosis, and treatment implications.
authors.affiliation: Pediatric Pulmonology Unit, Rambam Medical Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Bentur
authors.forename: J
authors.initials: J
authors.lastname: Lachter
authors.forename: I
authors.initials: I
authors.lastname: Koren
authors.forename: O
authors.initials: O
authors.lastname: Ben-Izhak
authors.forename: A
authors.initials: A
authors.lastname: Lavy
authors.forename: Y
authors.initials: Y
authors.lastname: Bentur
authors.forename: E
authors.initials: E
authors.lastname: Rosenthal
mesh_terms: D000293:Adolescent; D001989:Bronchiolitis Obliterans / Q000150:complications* / Q000175:diagnosis; D003424:Crohn Disease / Q000150:complications*; D003937:Diagnosis, Differential; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000175:diagnosis