title: An autonomous cell-cycle oscillator involved in the coordination of G1 events.
abstract: In early embryonic development, the cell cycle is paced by a biochemical oscillator involving cyclins and cyclin-dependent kinases (cdks). Essentially the same machinery operates in all eukaryotic cells, although after the first few divisions various braking mechanisms (the so-called checkpoints) become significant. Haase and Reed have recently shown that yeast cells have a second, independent oscillator which coordinates some of the events of the G1 phase of the cell cycle.(1) Although the biochemical nature of this oscillator is not known,it seems unlikely to be a redundant cyclin/cdk system. BioEssays 22:3-5, 2000.
authors.affiliation: Department of Chemistry and Biochemistry, University of Lethbridge, Lethbridge, Alberta, Canada T1K 3M4. roussel@uleth.ca
authors.forename: M R
authors.initials: MR
authors.lastname: Roussel
mesh_terms: D000818:Animals; D001683:Biological Clocks; D002453:Cell Cycle / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D016193:G1 Phase; D009991:Oscillometry; D012568:Schizosaccharomyces / Q000502:physiology
chemical_list: D018844:Cyclin-Dependent Kinases