title: [The effect of clofelin, guanfacine and compound SHA-9 on the transmembrane ion potentials of snail neurons].
abstract: The effect of central adrenopositive drugs--clopheline, guanfacine, and 2,4,6-trifluorine derivative of clopheline (SHA-9)--on Na, Ca, fast and slow K transmembrane ion currents in Lymnaea stagnalis neurons was studied using the intercell dialysis and voltage-clamp upon bath application of the drugs in doses 1-1000 microM. A dose-dependent reversible suppression of the ion (Na > Ca > K) currents and nonspecific leakage currents is observed. The membrane stabilizing effect of the drugs comes out in descending order SHA-9 > clopheline > guanfacine.
authors.affiliation: Valdman Institute of Pharmacology, Pavlov Medical University, St. Petersburg, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Savos'kin
authors.forename: A I
authors.initials: AI
authors.lastname: Vislobokov
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016316:Guanfacine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008195:Lymnaea / Q000187:drug effects* / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology
chemical_list: D000316:Adrenergic alpha-Agonists; D015220:Calcium Channels; D015221:Potassium Channels; D015222:Sodium Channels; D016316:Guanfacine; D003000:Clonidine