[The effect of the prolonged action of cytostatics and hormones on the properties of Escherichia coli].
Cytostatics and hormones were studied for their effect on biological peculiarities of Escherichia coli--the main agent of inflammatory processes of kidneys and urinary tracts in children and adults. It was established that low doses of glucocorticoids, cytostatics and their combinations lead to changes in morphological properties in the strain of E. coli: M- and R-forms appeared in some variants. Besides, changes in a number of the biochemical peculiarities of M- and R-forms were found. These peculiarities are taken into account during identification of these microorganisms. The decrease of adhesion activity in almost all variants of E. coli 2417 was registered under long-term cultivation with cytostatics and prednisolone; hemolytic activity and ability to hydrolyze DNA were also established in certain variants.
Rudenko
A V
AV
Institute of Urology and Nephrology, Academy of Medical Sciences of Ukraine, Kyiv.
Brud'ko
A P
AP
Vorobeĭ
N V
NV
Suslova
H D
HD
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D003851:Deoxyribonucleases / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000382:microbiology; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000472:pathogenicity; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D012692:Serial Passage; D013997:Time Factors
D000970:Antineoplastic Agents; D006728:Hormones; D007166:Immunosuppressive Agents; D003851:Deoxyribonucleases