title: [Melatonin effects on functional activity of platelets in patients with bronchial asthma].
abstract: OBJECTIVE
  To assess effects of epiphysial hormone melatonin in various dose regimens on ADP-induced aggregation of platelets in patients with bronchial asthma (BA). Correlations with urine levels of 6-sulphatoxymelatonin (6-SOMT), basic melatonin metabolite, were made.
  
  
  METHODS
  Melatonin was given to 17 patients with mild or moderate BA and 16 healthy controls.
  
  
  RESULTS
  BA patients were found to have disorders in circadian rhythm of urine 6-SOMT excretion, lack of correlation between platelet functional activity and elevated nocturnal excretion of 6-SOMT, in vitro platelet activation in response to low-dose melatonin and absence of this reaction to high-dose melatonin.
  
  
  CONCLUSIONS
  It is suggested that melatonin may be involved in genesis of bronchoobstructive syndrome in BA.
authors.forename: E V
authors.initials: EV
authors.lastname: Evsiukova
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001249:Asthma / Q000097:blood* / Q000188:drug therapy / Q000652:urine; D015415:Biomarkers / Q000652:urine; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000652:urine; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D015415:Biomarkers; C054513:6-sulfatoxymelatonin; D008550:Melatonin