title: Antiplatelets activity of some xanthone derivatives.
abstract: The effects of twelve aminoalkanolic derivatives of xanthone on platelet aggregation have been evaluated. Five from them inhibited thrombin-induced platelet aggregation. The most active compound was R-(+)-2-N-(7-chloro-2-xanthonemethyl)-2-N-methylamino-1-butanol [IV] which, at a concentration of 40 micrograms/ml, nearly completely inhibited the aggregation concentration (TAC) of thrombin.
authors.affiliation: Department of Pharmacology and Toxicology, Medical University School, Lublin, Poland.
authors.forename: G
authors.initials: G
authors.lastname: Rajtar
authors.forename: D
authors.initials: D
authors.lastname: Zółkowska
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: H
authors.initials: H
authors.lastname: Marona
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000494:pharmacology
chemical_list: D010975:Platelet Aggregation Inhibitors; D013917:Thrombin