[The possibility of using Daphnia magna as an alternative test object for evaluating the receptor selectivity of cholinotropic substances].
The results of study of the selectivity of the effects of cholinonegative and cholinopositive agents obtained on Daphnia magna hydrobionts were compared with the results of investigations on rats. This allowed Daphnia to be recommended as an alternative test object for studying the selectivity of the effect of cholinotropic agents in relation to some subtypes of muscarine receptors in an intact organism.
Tonkopiĭ
V D
VD
Institute of Science of the Lakes, Russian Academy of Sciences, St. Petersburg, Russia.
Kosmachev
A B
AB
Zagrebin
A O
AO
Fil'ko
O A
OA
D000818:Animals; D018679:Cholinergic Agonists / Q000494:pharmacology*; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003621:Daphnia / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects*
C404003:2,4,6-trifluorine clopheline; D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D011976:Receptors, Muscarinic; D003000:Clonidine