title: Antibacterial activity of pure flavonoids isolated from mosses.
abstract: Seven pure flavonoids were isolated and identified from five moss species. The flavonoids were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside, saponarine and vitexin; and the biflavonoid bartramiaflavone. Some of these flavonoids were shown to have pronounced antibacterial effects against Enterobacter cloaceae, E. aerogenes and Pseudomonas aeruginosa (minimal bacteriostatic concentration MIC in the range of 4-2048 micrograms/ml). Because of their antibacterial spectrum mainly active against Gram negative bacterial strains, responsible for severe opportunistic infections and resistant to common antibacterial therapy, these flavonoids may be important tools in antibacterial strategies.
authors.affiliation: Dipartimento di Biologia Vegetale, Università Federico II, Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Basile
authors.forename: S
authors.initials: S
authors.lastname: Giordano
authors.forename: J A
authors.initials: JA
authors.lastname: López-Sáez
authors.forename: R C
authors.initials: RC
authors.lastname: Cobianchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019068:Bryopsida / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids