[Biological activity and structure of antitumor compounds from Plantago media L].
Tyrosine kinase inhibition and tumor growth inhibition activity of verbascoside and homoplantaginin are described. Both molecules proved to be equally significant inhibitors of isolated EGF-R tyrosine kinases, nevertheless their in vitro antiproliferative activity was variable in cellular assays. Their different inhibitory efficacies could be interpreted on the basis of conformational analysis and lipophilicity evaluation.
Kunvári
M
M
Eötvös Loránd Tudományegyetem, Növényszervezettani Tanszék, Budapest.
Páska
C
C
László
M
M
Orfi
L
L
Kövesdi
I
I
Eros
D
D
Bökönyi
G
G
Kéri
G
G
Gyurján
I
I
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D066246:ErbB Receptors / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D010636:Phenols; D010943:Plantago; D010946:Plants, Medicinal; D014407:Tumor Cells, Cultured; D059808:Polyphenols
D000972:Antineoplastic Agents, Phytogenic; D066246:ErbB Receptors; D005419:Flavonoids; D005960:Glucosides; D010636:Phenols; C403862:6-methoxy-4',5-dihydroxyflavone-7-O-glucoside; C058956:acteoside; D059808:Polyphenols