Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration.
We demonstrated intense serotonin (5-HT) 2A receptor immunoreactivity in the human ventral tegmental area (VTA) using by a recently raised antibody against 5-HT2A receptor. The substantia nigra (SN) neurons also showed 5-HT2A receptor immunoreactivity. Double immunohistochemistry of 5-HT2A receptor and tyrosine hydroxylase (TH) revealed many neurons doubly labeled by 5-HT2A receptor and TH in the VTA and SN. It is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-HT2A receptors at the level of their originating nuclei.
Ikemoto
K
K
Department of Anatomy, School of Medicine, Fujita Heath University, Toyoake, Aichi 470-1192, Japan. kikemoto@fujita-hu.ac.jp
Nishimura
A
A
Okado
N
N
Mikuni
M
M
Nishi
K
K
Nagatsu
I
I
D000328:Adult; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000096:biosynthesis*; D013378:Substantia Nigra / Q000166:cytology / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D017557:Ventral Tegmental Area / Q000166:cytology / Q000201:enzymology*
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine