[Involvement of the peripheral nervous system in Crohn disease].
In medical literature peripheral neurological disorders are associated with Crohn's disease only in particular cases. We report on two patients who suffering from Crohn's disease developed an acute Guillain-Barré syndrome or a polyneuropathy associated with myositis. Two weeks after a 65-year old female patient developed a serious Guillain-Barré syndrome, a haemorrhagical Crohn's colitis was diagnosed. Within a few weeks the specific therapy led to a satisfying recovery. A 45-year old female had suffered from Crohn's disease since 12 years. Within 8 weeks she developed a serious sensorimotor mixed axonal and demyelinating neuropathy and a granulomatous myositis. After treatment with steroids her signs constantly decreased. These observations as well as a literature review show that polyneuropathy and Guillain-Barré syndrome can be associated with chronic inflammatory bowel diseases. Our results suggest that peripheral neurological signs could be regarded as a possible extraintestinal manifestation of inflammatory bowel disease.
Moormann
B
B
Neurologische Klinik, Klinikum Kassel.
Herath
H
H
Mann
O
O
Ferbert
A
A
D000368:Aged; D001369:Axons / Q000473:pathology; D001706:Biopsy; D003106:Colon / Q000473:pathology; D003424:Crohn Disease / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology; D017285:Polymyositis / Q000175:diagnosis* / Q000473:pathology