Zopiclone use during pregnancy.
OBJECTIVE
One of my patients, whom I had treated with a 2-week course of zopiclone for insomnia, conceived while using the medication. She is concerned. How should I advise her?


CONCLUSIONS
Based on available, albeit limited, evidence, zopiclone does not appear to be a major human teratogen.
Diav-Citrin
O
O
Hospital for Sick Children, Toronto.
Okotore
B
B
Lucarelli
K
K
Koren
G
G
D000014:Abnormalities, Drug-Induced; D000328:Adult; D053961:Azabicyclo Compounds; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*
D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; C515050:zopiclone