title: Improvement of eosinophilic heart disease after steroid therapy: successful demonstration by endomyocardial biopsied specimens.
abstract: A 62-year-old man with acute eosinophilic endomyocarditis developed congestive heart failure. The biopsy specimens revealed degranulated eosinophils and eosinophil cationic protein (ECP) in the endocardium, and in activated eosinophils and the myocardial interstitium. On electronmicroscopy, a characteristic cardiac myocytolytic change showing disruption at the intercellular junctional site was observed. After steroid treatment, clinical symptoms, systolic dysfunction and laboratory data dramatically improved. In the subsequent biopsy specimens, eosinophilic infiltration and ECP disappeared. Steroid therapy provided a beneficial effect in preventing the progression of cardiac damage. This effect was clearly documented by histochemical studies of the serial endomyocardial biopsy samples.
authors.affiliation: The First Department of Internal Medicine, Shinshu University, School of Medicine, Asahi, Matsumoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Isobe
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
mesh_terms: D001706:Biopsy; D005938:Glucocorticoids / Q000627:therapeutic use*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone