title: Total Synthesis of the Antimicrotubule Agent (+)-Discodermolide Using Boron-Mediated Aldol Reactions of Chiral Ketones.
abstract: With a similar mechanism of action to taxol, the title compound 1 is a particularly promising candidate for development in cancer chemotherapy. This efficient synthesis, based on stereocontrolled aldol reactions, should help to overcome the scarce natural supply of 1 from the rare sponge source.
authors.affiliation: University Chemical Laboratory Lensfield Road, Cambridge CB2 1EW (UK).
authors.initials: I
authors.lastname: Paterson
authors.initials: GJ
authors.lastname: Florence
authors.initials: K
authors.lastname: Gerlach
authors.initials: JP
authors.lastname: Scott