MAP1B expression and microtubule stability in growing and regenerating axons.
MAP1B is a microtubule-associated phosphoprotein that is particularly highly expressed in developing neurons. There is experimental evidence that it plays an important role in neuronal differentiation, especially the extension of axons and dendrites, but exactly what role is unclear. Recent experiments have shed light on the gene structure of MAP1B and identified some of the kinases that phosphorylate the protein. Implicit in these findings is the idea that MAP1B regulates the organisation of microtubules in neurites and is itself regulated in a complex way and at a number of levels.
Gordon-Weeks
P R
PR
Centre for Developmental Neurobiology, GKT School of Biomedical Sciences, King's College London, London WC2B 5RL. phillip.gordon-weeks@kcl.ac.uk
Fischer
I
I
D000818:Animals; D001369:Axons / Q000201:enzymology / Q000502:physiology*; D002454:Cell Differentiation; D004789:Enzyme Activation; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D008870:Microtubules / Q000378:metabolism*; D009416:Nerve Regeneration; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D008869:Microtubule-Associated Proteins; C085284:microtubule-associated protein 1B; D017346:Protein Serine-Threonine Kinases; D010749:Phosphoprotein Phosphatases