c-Fos induction in response to saccharin after taste aversion learning depends on conditioning method.
Increases in c-Fos-like immunoreactivity (FLI) in the intermediate nucleus of the solitary tract (iNTS) have been seen consistently as a correlate of the expression of a conditioned taste aversion (CTA) when conditioning occurs using taste delivery through intraoral (I/O) infusions. The present study examined whether a similar FLI response would occur when conditioning was accomplished by presenting the taste solution in a bottle. I/O and bottle methods generated aversions that were comparable, when judged by the behavioral response of solution rejection. However, elevations in FLI were seen only in animals conditioned with the I/O method. This finding adds to evidence that the neural pathways underlying CTA learning differ as a function of the type of conditioning method used.
Spray
K J
KJ
Department of Psychology, University of Washington, Seattle 98195-1525, USA.
Halsell
C B
CB
Bernstein
I L
IL
D000284:Administration, Oral; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003213:Conditioning, Psychological; D007267:Injections; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000502:physiology; D012439:Saccharin / Q000008:administration & dosage* / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013549:Sweetening Agents / Q000008:administration & dosage* / Q000494:pharmacology; D013649:Taste / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos; D013549:Sweetening Agents; D012965:Sodium Chloride; D012439:Saccharin; D018021:Lithium Chloride