title: A New Enantioselective Approach to Total Synthesis of the Securinega Alkaloids: Application to (-)-Norsecurinine and Phyllanthine.
abstract: An inexpensive proline derivative and chiral control feature in the total synthesis of securinega alkaloids (-)-norsecurinine (1) and phyllanthine (2). Key steps in the synthesis of 1 include an intramolecular ketonitrile coupling and application of a radical-based generation of N-acylimines. The total synthesis of 2 utilizes a stereoselective imino Diels - Alder construction of the methoxypiperidine ring.
authors.affiliation: Department of Chemistry The Pennsylvania State University University Park, PA 16802 (USA).
authors.initials: G
authors.lastname: Han
authors.initials: MG
authors.lastname: LaPorte
authors.initials: JJ
authors.lastname: Folmer
authors.initials: KM
authors.lastname: Werner
authors.initials: SM
authors.lastname: Weinreb