Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein.
In the present study, we examined whether the relative levels of regional brain [14C]2-deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of Alzheimer's disease which overexpresses a mutated form of the human beta-amyloid precursor protein (mutation V717F). We show that the relative levels of 2-DG uptake are significantly reduced in the septum, thalamus, dentate gyrus and parietal cortex of 3-month-old transgenic mice as compared with wild-type littermates. In 10-month-old transgenic mice, these alterations also extend to the CA3 hippocampal region, the cingulate, retrosplenial, occipital and temporal cortices, suggesting an age-dependent decrease in the regional 2-DG uptake. These results suggest that expression of a mutated APP gene induces an early regional cerebral hypometabolism independently of amyloid deposition per se.
Dodart
J C
JC
Laboratoire d'Ethologie et Neurobiologie, Université Louis Pasteur, URA 1295 CNRS, Strasbourg, France. jcdodart@currif.u-strasbg.fr
Mathis
C
C
Bales
K R
KR
Paul
S M
SM
Ungerer
A
A
D000367:Age Factors; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology; D003847:Deoxyglucose / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic / Q000378:metabolism*; D016548:Prosencephalon / Q000378:metabolism*; D013997:Time Factors
D016564:Amyloid beta-Protein Precursor; D003847:Deoxyglucose; D005947:Glucose