[The correction of the increased blood viscosity syndrome in brain ischemia in rats with a combination of dikvertin and ascorbic acid].
In experiments in vitro on a model of the syndrome of increased blood viscosity dikvertin reduced blood viscosity, weakened aggregation of red cells and raised their property of becoming distorted. A mixture of dikvertin and ascorbic acid improved the hemorrheologic parameters better than do dikvertin and tanakan. On a model of chronic ischemia of the brain of rats attended with deterioration of blood rheologic parameters, it was demonstrated that a course of treatment with a dikvertin and ascorbic acid complex decreases the manifestations of the syndrome of increased blood viscosity.
Plotnikov
M B
MB
Laboratory of Pharmacology of Circulation, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Aliev
O I
OI
Maslov
M Iu
MIu
Vasil'ev
A S
AS
Tiukavkina
N A
NA
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001809:Blood Viscosity / Q000187:drug effects*; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005419:Flavonoids / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use; D020441:Ginkgo biloba; D066298:In Vitro Techniques; D008297:Male; D010936:Plant Extracts; D011794:Quercetin; D051381:Rats; D013577:Syndrome; D000096983:Ginkgo Extract
D000975:Antioxidants; D001205:Ascorbic Acid; D005419:Flavonoids; D016166:Free Radical Scavengers; D010936:Plant Extracts; D011794:Quercetin; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract