A population of murine gammadelta T cells that recognize an inducible MHC class Ib molecule.
Although gammadelta T cells are implicated in regulating immune responses, gammadelta T cell-ligand pairs that could mediate such regulatory functions have not been identified. Here, the expression of the major histocompatibility complex (MHC) class Ib T22 and the closely related T10 molecules is shown to be activation-induced, and they confer specificity to about 0.4% of the gammadelta T cells in normal mice. Thus, the increased expression of T22 and/or T10 might trigger immunoregulatory gammadelta T cells during immune responses. Furthermore, the fast on-rates and slow off-rates that characterize this receptor/ligand interaction would compensate for the low ligand stability and suggest a high threshold for gammadelta T cell activation.
Crowley
M P
MP
Program in Immunology, Department of Microbiology and Immunology, and Stanford University School of Medicine, Stanford, CA 94305, USA.
Fahrer
A M
AM
Baumgarth
N
N
Hampl
J
J
Gutgemann
I
I
Teyton
L
L
Chien
Y
Y
D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D019281:Dimerization; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011506:Proteins / Q000276:immunology* / Q000378:metabolism; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D001613:beta 2-Microglobulin / Q000276:immunology
D015395:Histocompatibility Antigens Class I; D008024:Ligands; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; D001613:beta 2-Microglobulin; C089395:T22 antigen