title: Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration.
abstract: We demonstrated intense serotonin (5-HT) 2A receptor immunoreactivity in the human ventral tegmental area (VTA) using by a recently raised antibody against 5-HT2A receptor. The substantia nigra (SN) neurons also showed 5-HT2A receptor immunoreactivity. Double immunohistochemistry of 5-HT2A receptor and tyrosine hydroxylase (TH) revealed many neurons doubly labeled by 5-HT2A receptor and TH in the VTA and SN. It is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-HT2A receptors at the level of their originating nuclei.
authors.affiliation: Department of Anatomy, School of Medicine, Fujita Heath University, Toyoake, Aichi 470-1192, Japan. kikemoto@fujita-hu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ikemoto
authors.forename: A
authors.initials: A
authors.lastname: Nishimura
authors.forename: N
authors.initials: N
authors.lastname: Okado
authors.forename: M
authors.initials: M
authors.lastname: Mikuni
authors.forename: K
authors.initials: K
authors.lastname: Nishi
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
mesh_terms: D000328:Adult; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000096:biosynthesis*; D013378:Substantia Nigra / Q000166:cytology / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D017557:Ventral Tegmental Area / Q000166:cytology / Q000201:enzymology*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine