title: 99Tcm-p-aminohippuric acid as a new renal agent.
abstract: 99Tcm-p-aminohippuric acid (99Tcm-PAH) is a new renal radiopharmaceutical prepared from a lyophilized kit by the addition of sodium pertechnetate (Na99TcmO4). Each vial contains PAH, the calcium trisodium salt of diethylenetriamine pentaacetic acid (CaNa3DTPA) and stannous chloride (SnCl2.2H2O) in an inert atmosphere. It is a stable radiopharmaceutical with high radiochemical purity (> 95%). Its protein binding is very similar to that of 131I-OIH, but it is hydrophilic in character. Animal studies using 99Tcm-PAH have indicated that it provides renal images of satisfactory quality with no external background. Despite its almost identical radiochemical purity and HPLC analysis results to 99Tcm-DTPA, 99Tcm-PAH is rapidly secreted by the kidneys in a manner consistent with tubular secretion, as confirmed by rat probenecid studies, whereas 99Tcm-DTPA is excreted by glomerular filtration. The pharmacokinetic parameters of 99Tcm-PAH (t1/2(alpha)) = 2.5 min, t1/2(beta) = 41.7 min, Cl = 5.22 ml.min-1, Kel = 5.1 x 10(-4) min-1) differ from those of 99Tcm-DTPA. Evaluation of 99Tcm-PAH in two human volunteers confirmed its good renal characteristics: rapid disappearance from the vascular system, high uptake in kidneys followed by its very fast elimination, and low residual activity 20 min after its intravenous administration.
authors.affiliation: Vinca Institute of Nuclear Sciences, Belgrade, Yugoslavia. djokici@rt270.vin.bg.ac.yu
authors.forename: D
authors.initials: D
authors.lastname: Djokić
authors.forename: D
authors.initials: D
authors.lastname: Janković
authors.forename: T
authors.initials: T
authors.lastname: Maksin
authors.forename: E
authors.initials: E
authors.lastname: Jaksić
authors.forename: S
authors.initials: S
authors.lastname: Beatović
authors.forename: R
authors.initials: R
authors.lastname: Han
mesh_terms: D000818:Animals; D006801:Humans; D007202:Indicators and Reagents; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000502:physiology; D008297:Male; D008657:Metabolic Clearance Rate; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D011339:Probenecid / Q000494:pharmacology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D013667:Technetium / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D007202:Indicators and Reagents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012709:Serum Albumin; C405303:technetium Tc 99m-aminohippuric acid; D013667:Technetium; D011339:Probenecid