Estimation of population parameters and recombination rates from single nucleotide polymorphisms.
Some general likelihood and Bayesian methods for analyzing single nucleotide polymorphisms (SNPs) are presented. First, an efficient method for estimating demographic parameters from SNPs in linkage equilibrium is derived. The method is applied in the estimation of growth rates of a human population based on 37 SNP loci. It is demonstrated how ascertainment biases, due to biased sampling of loci, can be avoided, at least in some cases, by appropriate conditioning when calculating the likelihood function. Second, a Markov chain Monte Carlo (MCMC) method for analyzing linked SNPs is developed. This method can be used for Bayesian and likelihood inference on linked SNPs. The utility of the method is illustrated by estimating recombination rates in a human data set containing 17 SNPs and 60 individuals. Both methods are based on assumptions of low mutation rates.
Nielsen
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Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA. nielsen@oeb.harvard.edu
D008040:Genetic Linkage; D006801:Humans; D008390:Markov Chains; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic