title: Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children.
abstract: Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the "Italian Register for HIV infection in children", we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non-immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.
authors.affiliation: Department of Pediatrics, University of Turin, Italy. tovo@pediatria.unito.it
authors.forename: P A
authors.initials: PA
authors.lastname: Tovo
authors.forename: M
authors.initials: M
authors.lastname: de Martino
authors.forename: C
authors.initials: C
authors.lastname: Gabiano
authors.forename: L
authors.initials: L
authors.lastname: Galli
mesh_terms: D000942:Antigens, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000209:etiology / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects; D007223:Infant; D008297:Male; D018448:Models, Immunological; D010567:Pertussis Vaccine / Q000009:adverse effects / Q000276:immunology*; D011446:Prospective Studies; D012042:Registries; D012189:Retrospective Studies; D015164:Vaccines, Inactivated / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000942:Antigens, Bacterial; D010567:Pertussis Vaccine; D015164:Vaccines, Inactivated