Influence of pharmacological agents on portal hemodynamics: basis for its use in the treatment of portal hypertension.
Progress in the knowledge of the pathophysiology of portal hypertension has opened the door to pharmacological treatments, resulting in a dramatic change in the therapeutic approach to portal hypertension. This review summarizes pharmacological agents that have been shown to effectively decrease portal pressure, paying special attention to its mechanisms of action. In addition, the way to monitor response and clinical efficacy of pharmacological agents is reviewed.
García-Pagán
J C
JC
Hepatic Hemodynamic Laboratory, Hospital Clinic, IDIBAPS, University of Barcelona, Spain. jcgarcia@medicina.ub.es
Escorsell
A
A
Moitinho
E
E
Bosch
J
J
D000818:Animals; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy* / Q000503:physiopathology; D008102:Liver Circulation / Q000187:drug effects; D017082:Portal Pressure / Q000187:drug effects; D013152:Splanchnic Circulation / Q000187:drug effects