title: Bioavailability of starch and postprandial changes in splanchnic glucose metabolism in pigs.
abstract: Changes in splanchnic metabolism in pigs were assessed after meals containing slowly or rapidly digested starch. The pigs were fed a mixed meal containing a "slow" native (n = 5) or a "rapid" pregelatinized (n = 5) cornstarch naturally enriched with [(13)C]glucose. Absorption of [(13)C]glucose was monitored by the arteriovenous difference technique, and infusion of D-[6, 6-(2)H(2)]glucose in the jugular vein was used to calculate the systemic appearance of [(13)C]glucose. Arteriovenous balance data obtained during a 12-h study period showed that the fraction of ingested glucose equivalent appearing as glucose in the portal vein was 49.7 +/- 7.2% for the slow starch and 48.2 +/- 7.5% for the rapid starch (P = 0.86). These values, corrected for the gut extraction of circulating [(13)C]glucose, became 66.4 +/- 5.6 and 65. 3 +/- 5.6%, respectively (P = 0.35). Isotope dilution data indicated that systemic appearance of exogenous [(13)C]glucose represented 62. 9 +/- 7.6 and 67.4 +/- 3.0% of the oral load for slow and rapid starch, respectively (P = 0.68). Arterial glucose utilization by the gut increased from 7.3 +/- 0.9 micromol x kg(-1) x min(-1) before the meal to 8.5 +/- 1.6 micromol x kg(-1) x min(-1) during absorption, independently of the nature of the starch. Thus splanchnic glucose metabolism was unaffected by the nature of starch ingested.
authors.affiliation: Institut National de la Recherche Agronomique, 44316 Nantes, France.
authors.forename: L
authors.initials: L
authors.lastname: Noah
authors.forename: M
authors.initials: M
authors.lastname: Krempf
authors.forename: G
authors.initials: G
authors.lastname: Lecannu
authors.forename: P
authors.initials: P
authors.lastname: Maugère
authors.forename: M
authors.initials: M
authors.lastname: Champ
mesh_terms: D000818:Animals; D001682:Biological Availability; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism*; D002247:Carbon Isotopes; D002339:Carotid Arteries; D003903:Deuterium; D005260:Female; D005502:Food; D007408:Intestinal Absorption; D007700:Kinetics; D011169:Portal Vein; D013152:Splanchnic Circulation; D013213:Starch / Q000378:metabolism / Q000493:pharmacokinetics*; D013552:Swine / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D002247:Carbon Isotopes; D013213:Starch; D003903:Deuterium