Intravesicular instillation of E-aminocaproic acid for patients with adenovirus-induced hemorrhagic cystitis.
Hemorrhagic cystitis (HC) is a known complication of allogenic BMT. We report a case of a 28-year-old female with CML in chronic phase, which was treated with a matched unrelated donor (MUD) transplant, complicated by hemorrhagic cystitis on day +42 after the transplant. Adenovirus was isolated from the urine and she was treated with ribavirin, 1 g twice a day for 8 days. We report the use of Amicar (E-aminocaproic acid), 2.5 g solution as bladder instillation to treat the intractable hematuria.
Lakhani
A
A
Rush Cancer Institute, Rush University, Chicago, IL, USA.
Raptis
A
A
Frame
D
D
Simpson
D
D
Berkahn
L
L
Mellon-Reppen
S
S
Klingemann
H
H
D000257:Adenoviridae Infections; D000328:Adult; D015119:Aminocaproic Acid / Q000008:administration & dosage*; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003556:Cystitis / Q000188:drug therapy* / Q000821:virology; D005260:Female; D006417:Hematuria / Q000188:drug therapy* / Q000821:virology; D006801:Humans
D000933:Antifibrinolytic Agents; D015119:Aminocaproic Acid