Vitamin B12 levels during prolonged treatment with proton pump inhibitors.
Reduced serum vitamin B12 (cobalamin) levels have been documented occasionally during long-term treatment with a proton pump inhibitor (PPI) in selected groups of patients. This has largely been confined to patients being treated for Zollinger-Ellison syndrome who have sustained drug-induced achlorhydria, which does not ordinarily occur during treatment with a PPI. An appreciation of normal cobalamin metabolism and the pharmacological action of the PPIs adequately explain the mechanism for this reduction. PPIs do not promote the development of pernicious anemia.
Howden
C W
CW
Northwestern Center for Clinical Research, Northwestern University, Chicago, IL 60611, USA. c-howden@nwu.edu
D000042:Absorption; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D054328:Proton Pump Inhibitors; D013997:Time Factors; D014805:Vitamin B 12 / Q000097:blood*; D014806:Vitamin B 12 Deficiency / Q000097:blood / Q000503:physiopathology*
D054328:Proton Pump Inhibitors; D014805:Vitamin B 12