Analysis of association at single nucleotide polymorphisms in the APOE region.
The discussion of the prospects of using a dense map of single nucleotide polymorphisms (SNPs) to identify disease genes with association analysis has been extensive. However, there is little empiric evidence to support this strategy. To begin to examine the practical issues surrounding this methodology, we identified 10 SNPs in the region immediately surrounding the apolipoprotein E locus (APOE), an established susceptibility gene for Alzheimer disease. Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE.
Martin
E R
ER
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA. emartin@chg.mc.duke.edu
Gilbert
J R
JR
Lai
E H
EH
Riley
J
J
Rogala
A R
AR
Slotterbeck
B D
BD
Sipe
C A
CA
Grubber
J M
JM
Warren
L L
LL
Conneally
P M
PM
Saunders
A M
AM
Schmechel
D E
DE
Purvis
I
I
Pericak-Vance
M A
MA
Roses
A D
AD
Vance
J M
JM
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D001057:Apolipoproteins E; D005819:Genetic Markers