The future of bacterial vaginosis-related research.
Various ways and criteria are used to diagnose BV. Guidelines should be redrawn and they should embody greater uniformity. The etiology of BV remains enigmatic. However, various observations suggest that host factors, possibly hormonal, cause an imbalance in the vaginal microflora. Exogenous factors, such as semen and antibiotics, may then help to bring about a more prolonged change. This forms a working hypothesis for further exploration. The role of the lactobacillus phage in the development of BV also needs to be determined. Various conditions may occur as a consequence of BV in non-pregnant and pregnant women and BV may also affect men. A subjective assessment of the extent to which these associations occur or are likely to be shown to occur by further investigations is presented in Table 1. The ability to cure acute BV needs to be improved as does the treatment of chronic BV, for which vaginal recolonization with exogenous lactobacilli is an approach to be evaluated further.
Taylor-Robinson
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Genitourinary Medicine Unit, Imperial College School of Medicine, London, UK.
D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012106:Research; D016585:Vaginosis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology