title: Spontaneous lymphoma in a Japanese White rabbit.
abstract: Lymphoma was observed in a 4-month-old female Japanese White rabbit. Grossly, the markedly enlarged mesenteric lymph nodes, prominent Peyer's patches of jejunum, splenomegaly, and enlargement of tracheobronchial lymph nodes, adrenal glands and ovaries were observed. Histologically, neoplastic lymphoid cells proliferated diffusely showing frequent mitotic figures and a characteristic 'starry sky' appearance. Their basophilic cytoplasm contained a few lipid droplets. The mesenteric lymph nodes, Peyer's patches of jejunum, and tracheobronchial lymph nodes were largely replaced by the tumor tissues. The stomach, small intestines, especially the jejunum, liver, spleen, ovaries, and adrenal glands were heavily infiltrated with neoplastic cells. These results suggest that the present lymphoma may have originated from the gastrointestinal lymphoid tissue.
authors.affiliation: Nippon Institute for Biological Science, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shibuya
authors.forename: M
authors.initials: M
authors.lastname: Tajima
authors.forename: K
authors.initials: K
authors.lastname: Kanai
authors.forename: M
authors.initials: M
authors.lastname: Ihara
authors.forename: T
authors.initials: T
authors.lastname: Nunoya
mesh_terms: D000818:Animals; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D007583:Jejunum / Q000276:immunology / Q000473:pathology; D008099:Liver / Q000276:immunology / Q000473:pathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008223:Lymphoma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron / Q000662:veterinary; D010053:Ovary / Q000276:immunology / Q000473:pathology; D010581:Peyer's Patches / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013163:Splenomegaly / Q000662:veterinary