title: [Human reproduction and environmental risk factors].
abstract: Environmental pollution is a great cause of concern, in particular, growing attention is being paid to the potential of many chemicals to affect the reproductive system in humans. The key role of prevention and control of reproductive hazards is recognized world-wide. Many chemicals have been shown to impair fertility and/or prenatal and perinatal development in experimental studies. However, a sufficient evidence of an effect on human reproduction is available for some compounds only. The use of biological markers may improve the assessment of exposure to chemicals, contribute to identify mechanisms of action and put into evidence early, reversible, biological effects. Valid biological markers are also needed in epidemiological studies: without reliable data on the level of current and past exposures it is difficult to establish a causal relationship between a pollutant and the occurrence of adverse health effects. A multidisciplinary approach to risk assessment is required. Priorities for interdisciplinary research on environmental chemicals and reproduction include the identification of susceptible population subgroups and risk assessment of exposure to multiple chemicals.
authors.affiliation: Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Petrelli
authors.forename: A
authors.initials: A
authors.lastname: Mantovani
authors.forename: A
authors.initials: A
authors.lastname: Menditto
mesh_terms: D005314:Embryonic and Fetal Development / Q000187:drug effects; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000009:adverse effects*; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D012098:Reproduction / Q000187:drug effects*; D012307:Risk Factors
chemical_list: D004785:Environmental Pollutants