Involvement of dopamine D2 and 5-HT1A receptors in roxindole-induced antinociception.
Roxindole, a DA D2 receptor agonist (2-16 mg/kg) produced dose-dependent increase in percentage antinociception. The effect which was blocked by DA D2 antagonist (-)sulpiride (50 mg/kg) and 5-HT1A receptor antagonist (-) pindolol (5 mg/kg). Roxindole (4 and 8 mg/kg) reversed both naloxone (20 mg/kg)-induced hyperalgesia and reserpine (2 mg/kg)-induced hyperalgesia. This reversal was sensitive to blockade by both (-)sulpiride (50 mg/kg) and (-) pindolol (5 mg/kg). The present study suggests that roxindole-induced antinociception is mediated by postsynaptic DA D2 and 5-HT1A receptors.
Ninan
I
I
Pharmacology Division, Panjab University, Chandigarh, India.
Kulkarni
S K
SK
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D018491:Dopamine Agonists / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D000078183:Oxindoles; D010869:Pindolol / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology*; D017448:Receptors, Dopamine D2 / Q000502:physiology; D011985:Receptors, Serotonin / Q000502:physiology; D044263:Receptors, Serotonin, 5-HT1; D012110:Reserpine / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology
D000700:Analgesics; D018491:Dopamine Agonists; D007211:Indoles; D000078183:Oxindoles; D011725:Pyridines; D017448:Receptors, Dopamine D2; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D009270:Naloxone; C059613:roxindole; D013469:Sulpiride; D012110:Reserpine; D010869:Pindolol