title: [Diagnostic and therapeutic management of the superior vena cava syndrome].
abstract: BACKGROUND
  Superior vena cava syndrome (SVCS) is the clinical expression of obstruction of blood flow through the superior caval vein. In more than 80% of patients this complication is due to a malignant tumor, and in 60% of cases the first symptom of this tumor.
  
  
  METHODS
  If the clinical course of SVCS represents an absolute emergency, irradiation may have to be started immediately, even before the histologic diagnosis is established. Alternatively, expandable metallic stents have been used with considerable success for treatment of vena caval obstruction since patients respond immediately after stent implantation. For diagnosis, a chest X-ray and a CT scan should be performed. Chemotherapy is the treatment of choice for high-grade lymphomas, germ cell tumors and small-cell lung cancer since this modality is more effective than radiotherapy (response rate: 80%). For less chemotherapy responsive tumors radiotherapy is the primary treatment. Successful experience with thrombolytic agents is limited to treatment of catheter-induced SVCS, in contrast, only 20% of patients respond to thrombolytic therapy in the absence of a central catheter. Surgical resection of SVCS associated tumors has not improved survival rates and should be avoided.
authors.affiliation: Klinik und Poliklinik für Innere Medizin IV, Martin-Luther-Universität Halle-Wittenberg.
authors.forename: W
authors.initials: W
authors.lastname: Dempke
authors.forename: C
authors.initials: C
authors.lastname: Behrmann
authors.forename: C
authors.initials: C
authors.lastname: Schöber
authors.forename: T
authors.initials: T
authors.lastname: Büchele
authors.forename: A
authors.initials: A
authors.lastname: Grothey
authors.forename: H J
authors.initials: HJ
authors.lastname: Schmoll
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D006801:Humans; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D015607:Stents; D013479:Superior Vena Cava Syndrome / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D019616:Thoracic Surgical Procedures; D015912:Thrombolytic Therapy; D014656:Vascular Surgical Procedures