title: Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.
abstract: Altered lipid metabolism is closely associated with diabetes in humans, although predisposing genetic factors that affect hyperlipidemia have not yet been clarified. Our previously established OLETF strain is an obese rat model of type II diabetes, exhibiting hypertriglycemia as well as hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. To identify genetic factors responsible for dyslipidemic phenotypes in OLETF rats, we performed a whole-genome scan using 293 male (OLETF x BN) x OLETF backcross rats. Our analysis identified two significant quantitative trait loci (QTLs), on rat chromosomes 1 and 8, that are related to fasting triglyceride levels. The chromosome 1 QTL colocalized with Dmo1 (diabetes mellitus, OLETF type 1), a locus previously shown to associate strongly with both fat levels and body weight. The other significant QTL localizes to the chromosome 8 marker D8Mit2, in a region where several apo-lipoprotein genes are clustered.
authors.affiliation: Otsuka GEN Research Institute, Otsuka Pharmaceutical Co., Ltd., 463-10 Kagasuno, Kawauchi-cho, Tokushima, 771-0192, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okuno
authors.forename: T K
authors.initials: TK
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: H
authors.initials: H
authors.lastname: Miyao
authors.forename: T
authors.initials: T
authors.lastname: Asai
authors.forename: N
authors.initials: N
authors.lastname: Kanemoto
authors.forename: K
authors.initials: K
authors.lastname: Oga
authors.forename: A
authors.initials: A
authors.lastname: Mizoguchi-Miyakita
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: E
authors.initials: E
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: A
authors.initials: A
authors.lastname: Tanigami
mesh_terms: D000818:Animals; D001835:Body Weight / Q000235:genetics; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D003433:Crosses, Genetic; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D004195:Disease Models, Animal; D008040:Genetic Linkage; D015228:Hypertriglyceridemia / Q000097:blood / Q000235:genetics*; D008126:Lod Score; D008297:Male; D009765:Obesity / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D051381:Rats; D011914:Rats, Inbred BN; D020334:Rats, Inbred OLETF; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides