A case of hemolytic uremic syndrome improved with nitric oxide.
Hemolytic uremic syndrome (HUS) after transplantation is difficult to treat, and there is no consensus regarding optimal mode of treatment. We attached transdermal isosorbide tape as a nitric oxide (NO) donor to patients with HUS after bone marrow transplantation (BMT). This was very effective in ameliorating the hemolysis and increasing platelet numbers. We report here the successful use of an isosorbide in a patient with HUS after transplantation. Bone Marrow Transplantation (2000) 25, 109-110.
Kajiume
T
T
Department of Pediatrics, Kawasaki Medical School, Okayama, Japan.
Nagita
A
A
Yoshimi
S
S
Kobayashi
K
K
Kataoka
N
N
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D004234:Diuretics, Osmotic / Q000008:administration & dosage*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007547:Isosorbide / Q000008:administration & dosage*; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000008:administration & dosage*
D004234:Diuretics, Osmotic; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D007547:Isosorbide