Childhood myeloproliferative disorders.
Disorders classified as paediatric myeloproliferative disorders (MPD), such as juvenile chronic myeloid leukaemia (JCML), and as paediatric myelodysplastic syndrome (MDS), are essentially diseases characterized by abnormal myeloproliferation and they share similar genetic events on chromosome 7. As such, the abnormalities of increased myeloproliferation in childhood (AIMC) should be considered under the same heading. Constitutional and other genetic factors play an essential role in children and include the NF1 gene, whereas toxic exposure is of greater importance in adults. The most common cytogenetic alteration is that of monosomy or deletion of the long arm of chromosome 7. Critical regions have been identified and mapped by fluorescence in situ hybridization (FISH). It appears that the similar critical regions on chromosome 7 are involved, and suggests that these regions may contain genes important in the pathogenesis of AIMC.
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Molecular Haematology Unit, Institute of Child Health, London, UK.
D000328:Adult; D017668:Age of Onset; D017209:Apoptosis; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics / Q000648:ultrastructure; D002999:Clone Cells / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D004314:Down Syndrome / Q000150:complications; D005199:Fanconi Anemia / Q000150:complications; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015994:Incidence; D007223:Infant; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000145:classification / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D008297:Male; D009006:Monosomy; D009196:Myeloproliferative Disorders / Q000145:classification / Q000235:genetics / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000150:complications; D009503:Neutropenia / Q000150:complications / Q000151:congenital; D012150:Polymorphism, Restriction Fragment Length