New insights in the development of Dupuytren's contracture: a review.
Recent advances in the understanding of myofibroblast histology and function, the activity of fibrogenic cytokines, the role of the extracellular matrix and of free radicals are contributing to an understanding of the aetiology of Dupuytren's disease but not yet to its treatment. Surgical excision remains the best treatment.
Kloen
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Department of Orthopaedic Surgery, Massachusetts General Hospital and Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
D004387:Dupuytren Contracture / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005609:Free Radicals / Q000378:metabolism; D006133:Growth Substances / Q000502:physiology; D006801:Humans
D005609:Free Radicals; D006133:Growth Substances