Alternative mitochondrial functions in cell physiopathology: beyond ATP production.
It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
Kowaltowski
A J
AJ
Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil. alicia@bmb.ogi.edu
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D017209:Apoptosis / Q000502:physiology*; D001831:Body Temperature; D002118:Calcium / Q000378:metabolism; D006706:Homeostasis; D008928:Mitochondria / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate; D002118:Calcium