Agrochelin, a new cytotoxic antibiotic from a marine Agrobacterium. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Agrochelin, a new alkaloid cytotoxic substance, was produced by the fermentation of Agrobacterium sp. The compound was obtained from the bacterial cells by solvent extraction and purified by silica gel chromatography. Agrochelin (1) and its acetyl derivative (2) exhibited cytotoxic activity.
Acebal
C
C
Instituto Biomar S.A. Pol. Ind. de Leon. Edif. CEI, Onzonilla, León, Spain.
Cañedo
L M
LM
Puentes
J L
JL
Baz
J P
JP
Romero
F
F
de la Calle
F
F
Grávalos
M D
MD
Rodriguez
P
P
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D051379:Mice; D012231:Rhizobium / Q000145:classification* / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; D013844:Thiazoles; C403866:agrochelin