title: Sexual development of Taenia solium in hamsters from rodent-derived cysticerci.
abstract: In order to determine whether Taenia solium can be maintained in the laboratory using rodents as definitive hosts, six nude rats, 20 immunosuppressed Mongolian gerbils and 20 immunosuppressed Syrian hamsters were each inoculated through a stomach tube with three cysticerci recovered from SCID mice. No adult worms of T. solium were found in the intestinal tract of any of these 46 rodents. In addition, five immunosuppressed Syrian hamsters were fed with the same number of cysticerci enclosed in rodent muscles from SCID mice. Two of these hamsters were found to be infected 40 days post-infection, each harbouring a sexually developed worm in the intestinal tract. Although no eggs were produced, prepatent infections may be possible if a longer time was allowed for worm development. Moreover, the maintenance of the life cycle of T. solium in the laboratory using the rodent model can be established.
authors.affiliation: Institute and Department of Parasitology, National Yangming University, Taipei, Taiwan, Republic of China.
authors.forename: I C
authors.initials: IC
authors.lastname: Wang
authors.forename: J X
authors.initials: JX
authors.lastname: Guo
authors.forename: Y X
authors.initials: YX
authors.lastname: Ma
authors.forename: W C
authors.initials: WC
authors.lastname: Chung
authors.forename: S C
authors.initials: SC
authors.lastname: Lu
authors.forename: P C
authors.initials: PC
authors.lastname: Fan
mesh_terms: D000818:Animals; D006224:Cricetinae; D003552:Cysticercus / Q000254:growth & development; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005260:Female; D005849:Gerbillinae / Q000469:parasitology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008647:Mesocricetus / Q000469:parasitology*; D051379:Mice; D016513:Mice, SCID / Q000469:parasitology; D051381:Rats; D011923:Rats, Nude / Q000469:parasitology; D012741:Sexual Maturation; D013621:Taenia / Q000033:anatomy & histology / Q000254:growth & development*; D013622:Taeniasis / Q000276:immunology / Q000469:parasitology*