[Early stage of cardiomyopathy: mechanisms of damage and compensation].
In an experimental model of cardiomyopathy in Syrian hamsters, four principal phases were identified: lesion, reparation, compensation, and decompensation. Calcium overload seems to be a leading pathogenic factor in the 1st phase. If the action of damaging factor persists, the reparation phase is incomplete, and the compensation of the cardiac contractile function occurs due to an altered protein composition in the cells and extracellular matrix.
Kapel'ko
V I
VI
Cardiological Research-Industrial Complex, Moscow, Russia.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D002118:Calcium / Q000378:metabolism; D009202:Cardiomyopathies / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006224:Cricetinae; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000633:toxicity; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051381:Rats
D000970:Antineoplastic Agents; D004317:Doxorubicin; D002118:Calcium