Influence of interferon-alpha2b (IFN-alpha2b) on the prevention of locally advanced bladder carcinoma in mice.
In the model of chemically induced bladder carcinoma in mice following application of betahydroxylbutylnitrosamine (BBN) we could not detect a therapeutic influence of systemic treatment with intraperitoneal injection of interferon-alpha2b (10x3x10(5) IU IFN-alpha2b) on the rate of locally advanced bladder carcinoma (IFN-alpha2b 37% versus control 41%) nor on the development of tumor precursors (severe dysplasia 100% in both groups).
Otto
T
T
Clinic of Urology, University of Essen Medical School, Germany.
Bex
A
A
Lümmen
G
G
Rübben
H
H
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005260:Female; D007274:Injections, Intraperitoneal; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D011994:Recombinant Proteins; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins