title: Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis.
abstract: OBJECTIVE
  To correlate microvascular abnormalities, evaluated by nailfold videocapillaroscopy (NVC), with the duration of both Raynaud's phenomenon (RP) and systemic sclerosis (SSc) from the date of diagnosis, in a large number of patients with SSc.
  
  
  METHODS
  Ninety-seven consecutive patients were recruited and distributed into 3 groups on the basis of the morphological NVC patterns observed: "early" (E), "active" (A), and "late" (L). In each group the age of patients, age at onset, and the duration of RP as well as of overt SSc were investigated and correlated with the different NVC pattern variables.
  
  
  RESULTS
  The early appearance of giant capillaries and hemorrhages (E pattern) is of great relevance for the early diagnosis of SSc. Therefore, these alterations are more evident in the active phase of the disease (A pattern). Conversely, the NVC observation of loss of capillaries and vascular architectural disorganization and the presence of ramified/bushy capillaries (L pattern) represents the clearest aspect of advanced SSc microvascular damage. These morphological alterations were found to correlate significantly with the duration of both RP and SSc, as well as with age of patients (p = 0.0001). No significant differences were observed when the variables were analyzed in the patients classified as having limited cutaneous SSc or diffuse cutaneous SSc.
  
  
  CONCLUSIONS
  Classification of defined major nailfold patterns may be useful in assessing the appearance and progression of sclerodermic microangiopathy. As well, nailfold changes might represent a morphological reproduction of the evolution of SSc.
authors.affiliation: Department of Internal Medicine, University of Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Cutolo
authors.forename: A
authors.initials: A
authors.lastname: Sulli
authors.forename: C
authors.initials: C
authors.lastname: Pizzorni
authors.forename: S
authors.initials: S
authors.lastname: Accardo
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D020678:Microscopic Angioscopy; D008875:Middle Aged; D009262:Nails / Q000098:blood supply / Q000473:pathology*; D011928:Raynaud Disease / Q000150:complications / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications / Q000473:pathology*; D013997:Time Factors; D014741:Video Recording