title: Intravesicular instillation of E-aminocaproic acid for patients with adenovirus-induced hemorrhagic cystitis.
abstract: Hemorrhagic cystitis (HC) is a known complication of allogenic BMT. We report a case of a 28-year-old female with CML in chronic phase, which was treated with a matched unrelated donor (MUD) transplant, complicated by hemorrhagic cystitis on day +42 after the transplant. Adenovirus was isolated from the urine and she was treated with ribavirin, 1 g twice a day for 8 days. We report the use of Amicar (E-aminocaproic acid), 2.5 g solution as bladder instillation to treat the intractable hematuria.
authors.affiliation: Rush Cancer Institute, Rush University, Chicago, IL, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lakhani
authors.forename: A
authors.initials: A
authors.lastname: Raptis
authors.forename: D
authors.initials: D
authors.lastname: Frame
authors.forename: D
authors.initials: D
authors.lastname: Simpson
authors.forename: L
authors.initials: L
authors.lastname: Berkahn
authors.forename: S
authors.initials: S
authors.lastname: Mellon-Reppen
authors.forename: H
authors.initials: H
authors.lastname: Klingemann
mesh_terms: D000257:Adenoviridae Infections; D000328:Adult; D015119:Aminocaproic Acid / Q000008:administration & dosage*; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D003556:Cystitis / Q000188:drug therapy* / Q000821:virology; D005260:Female; D006417:Hematuria / Q000188:drug therapy* / Q000821:virology; D006801:Humans
chemical_list: D000933:Antifibrinolytic Agents; D015119:Aminocaproic Acid