A tomato homeobox gene (HD-zip) is involved in limiting the spread of programmed cell death.
Antisense suppression in transgenic tomato plants of H52, a gene encoding a new homeodomain protein of the HD-Zip class, produces a conditional lethal phenotype. The transgenic lines that survive exhibit spontaneous misregulation of cell death control in leaves, which, once initiated, propagates and engulfs the entire leaf. Activation of defence genes, over-accumulation of ethylene and conjugated salicylic acid, and growth reduction of virulent pathogens also occurs in these plants. In wild-type plants, H52 is up-regulated upon infection, mirroring the generation of the oxidative burst which normally precedes the hypersensitive response (HR). Thus, H52 appears to be a transcription factor involved in cellular protection by limiting spread of programmed cell death in plants.
Mayda
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E
Instituto de Biología Molecular y Celular de Plantas (IBMCP), Universidad Politécnica, Camino de Vera s/n, 46022 Valencia, Spain.
Tornero
P
P
Conejero
V
V
Vera
P
P
D000595:Amino Acid Sequence; D017209:Apoptosis / Q000235:genetics*; D003001:Cloning, Molecular; D016373:DNA, Antisense; D005030:Ethylenes / Q000378:metabolism; D015723:Gene Library; D005801:Genes, Homeobox; D017343:Genes, Plant; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D016350:Leucine Zippers; D018551:Solanum lycopersicum / Q000166:cytology / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D010937:Plant Growth Regulators / Q000378:metabolism; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D030821:Plants, Genetically Modified; D017433:Protein Structure, Secondary; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D016373:DNA, Antisense; D005030:Ethylenes; C091850:HD-Zip protein, Helianthus annuus; D018398:Homeodomain Proteins; D010937:Plant Growth Regulators; D010940:Plant Proteins; D011994:Recombinant Proteins; C036216:ethylene