title: Early wound complications in advanced head and neck cancer treated with surgery and Ir 192 brachytherapy.
abstract: OBJECTIVE
  Brachytherapy, either as primary or adjuvant therapy, is increasingly used to treat head and neck cancer. Reports of complications from the use of brachytherapy as adjuvant therapy to surgical excision have been limited and primarily follow Iodine 125 (I125) therapy. Early complications include wound breakdown, infection, flap failure, and sepsis, and late complications may include osteoradionecrosis, bone marrow suppression, or carotid injuries. The authors sought to identify the early wound complications that follow adjuvant interstitial brachytherapy with iridium 192 (IrS92).
  
  
  METHODS
  A retrospective chart review of all patients receiving adjuvant brachytherapy at a tertiary medical center over a 4-year period.
  
  
  METHODS
  Nine patients receiving Ir192 brachytherapy via afterloading catheters placed during surgical resection for close or microscopically positive margin control were evaluated. It was used during primary therapy in six patients and at salvage surgery in three. Early complications were defined as those occurring within 6 weeks of surgical therapy.
  
  
  RESULTS
  The overall complication rate was 55% (5/9), and included significant wound breakdown in two patients, minor wound dehiscence in three, and wound infection, bacteremia, and local tissue erosion in one patient each. All complications occurred in patients receiving flap reconstruction and one patient required further surgery to manage the complication. Complication rates were not associated with patient age, site, prior radiotherapy, timing of therapy, number of catheters, or dosimetry.
  
  
  CONCLUSIONS
  The relatively high complication rate is acceptable, given the minor nature of most and the potential benefit of radiotherapy. Further study should be undertaken to identify those patients who will achieve maximum therapeutic benefit without prohibitive local complications.
authors.affiliation: Department of Otolaryngology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA. rsmith@montefiore.org
authors.forename: R V
authors.initials: RV
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Krevitt
authors.forename: S M
authors.initials: SM
authors.lastname: Yi
authors.forename: J J
authors.initials: JJ
authors.lastname: Beitler
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D015994:Incidence; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications* / Q000532:radiotherapy / Q000601:surgery; D011183:Postoperative Complications / Q000453:epidemiology*; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods; D013997:Time Factors
chemical_list: D007496:Iridium Radioisotopes