Enantioselective Total Synthesis of Epothilone A Using Multifunctional Asymmetric Catalyses.
A catalytic version has now been developed for the enantioselective total synthesis of epothilone A (1). The key is the use of multifunctional asymmetric catalyses for a direct aldol reaction and cyanosilylation. This successful approach demonstrated the usefulness of these reactions for the catalytic asymmetric synthesis of complex molecules.
Sawada
D
Graduate School of Pharmaceutical Sciences The University of Tokyo Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan).
Shibasaki
M