Neuronal organization of the utricular macula concerned with innervation of single vestibular neurons in the cat.
We investigated whether cross-striolar inhibition, which may increase sensitivity to linear acceleration, contributed to utricular (UT) afferent innervation of single vestibular neurons (VNs). Excitatory and inhibitory postsynaptic potentials (EPSPs, IPSPs, respectively) were recorded from VNs after focal stimulation of the UT macula (M). From a total of 83 VNs, 25 (30%) neurons received inputs from both sides of the UTM, and the response patterns were opposite, i.e. cross-striolar inhibition was observed. In roughly 2/3 of these neurons, stimulation of the medial side of the UTM evoked EPSPs, while stimulation of the lateral side evoked IPSPs. In the remaining 1/3 neurons, the response patterns were opposite. Thirty-two (39%) of the 83 neurons received the identical pattern of inputs from both sides of the UTM: EPSPs in 26 neurons and IPSPs in six neurons. Twenty-six (31%) of the 83 neurons received inputs from either the medial or the lateral side of the UTM. These findings suggest that cross-striolar inhibition existed in the UT system, although it was not a dominant circuit that increased the sensitivity as in the saccular system [15].
Ogawa
Y
Y
Department of Otorhinolaryngology, Tokyo Medical University, Japan.
Kushiro
K
K
Zakir
M
M
Sato
H
H
Uchino
Y
Y
D008267:Acoustic Maculae / Q000166:cytology*; D000818:Animals; D002415:Cats; D019706:Excitatory Postsynaptic Potentials; D018069:Hair Cells, Vestibular / Q000502:physiology / Q000648:ultrastructure*; D019416:Head Movements / Q000502:physiology; D009039:Motion Perception / Q000502:physiology*; D009334:Neck Muscles / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D012018:Reflex / Q000502:physiology; D014725:Vestibular Nerve / Q000502:physiology / Q000648:ultrastructure*