Candida infection of cerebrospinal fluid shunt devices: report of two cases and review of the literature.
Use of CSF shunt devices is a common practice in neurosurgery, and infection of the shunt is the most frequent complication. In spite of the fact that bacteria are the most widely implicated pathogens, reports of fungal infections, especially due to Candida sp., have increased in recent years. Their reported frequency ranges between 6% and 17%. Many factors have been implicated in the pathogenesis of Candida meningitis, such as broad spectrum antibiotics used in the treatment of a bacterial meningitis, steroids and indwelling bladder and intravenous catheters. The treatment of Candida meningitis still consists of systemic antifungal agents and removal of the shunt.
Montero
A
A
Department of Radiation Oncology, Clínica Puerta de Hierro, Madrid, Spain.
Romero
J
J
Vargas
J A
JA
Regueiro
C A
CA
Sánchez-Aloz
G
G
De Prados
F
F
De la Torre
A
A
Aragón
G
G
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016921:Meningitis, Fungal / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D012086:Reoperation; D016896:Treatment Outcome; D017287:Ventriculoperitoneal Shunt / Q000009:adverse effects*
D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole