title: Atrial fibrillation and tumor emboli as manifestations of metastatic leiomyosarcoma to the heart and lung.
abstract: Leiomyosarcoma is a malignant tumor of the smooth muscle that rarely occurs in the gastrointestinal tract. High-grade leiomyosarcomas of the rectosigmoid usually metastasize to the liver and lungs. Although it is unusual, metastases to the heart have been reported. When this occurs, the metastatic tumor usually seeds in the right atrium and pulmonary artery. We report on and discuss a patient who had atrial fibrillation, peripheral emboli, and thrombocytopenia resulting from a low-grade rectosigmoid leiomyosarcoma metastatic to the pulmonary vein and left atrium. Atrial fibrillation is not a common manifestation of malignant neoplasms that have spread to the heart. Surgical removal of the tumor terminated the arrhythmia and thrombocytopenia.
authors.affiliation: Brown University School of Medicine, Providence, RI, USA.
authors.forename: F F
authors.initials: FF
authors.lastname: Lopez
authors.forename: A
authors.initials: A
authors.lastname: Mangi
authors.forename: E
authors.initials: E
authors.lastname: Mylonakis
authors.forename: J L
authors.initials: JL
authors.lastname: Chen
authors.forename: F J
authors.initials: FJ
authors.lastname: Schiffman
mesh_terms: D001281:Atrial Fibrillation / Q000209:etiology*; D006325:Heart Atria; D006338:Heart Neoplasms / Q000150:complications / Q000556:secondary* / Q000601:surgery; D006801:Humans; D007890:Leiomyosarcoma / Q000150:complications / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D011651:Pulmonary Artery / Q000473:pathology; D012004:Rectal Neoplasms / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000473:pathology; D013921:Thrombocytopenia / Q000209:etiology