Mast cell stabilizing and lipoxygenase inhibitory activity of Cedrus deodara (Roxb.) Loud. wood oil.
Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 micrograms/ml. C. deodara wood oil also significantly inhibited the enzyme lipoxygenase at a concentration of 200 micrograms/ml. Thus, the anti-inflammatory activity of C. deodara wood oil could be attributed to its mast cell stabilizing activity and the inhibition of leukotriene synthesis.
Shinde
U A
UA
Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, India.
Kulkarni
K R
KR
Phadke
A S
AS
Nair
A M
AM
Mungantiwar
A A
AA
Dikshit
V J
VJ
Saraf
M N
MN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D015550:Cell Degranulation / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014197:Trees; D003189:p-Methoxy-N-methylphenethylamine / Q000633:toxicity
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016859:Lipoxygenase Inhibitors; D010938:Plant Oils; D003189:p-Methoxy-N-methylphenethylamine