title: The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes.
abstract: Developmental regulators and cell cycle regulators have to interface in order to ensure appropriate cell proliferation during organogenesis. Our analysis of the roles of the pan-neural genes deadpan and asense defines critical roles for these genes in regulation of mitotic activities in the larval optic lobes. Loss of deadpan results in reduced cell proliferation, while ectopic deadpan expression causes over-proliferation. In contrast, loss of asense results in increased proliferation, while ectopic asense expression causes reduced proliferation. Consistent with these observations endogenous Deadpan is expressed in mitotic areas of the optic lobes, and endogenous Asense is expressed in cells that will become quiescent. Altered Deadpan or Asense expression results in altered expression of the cyclin dependent kinase inhibitor gene dacapo. Thus, regulation of mitotic activity during optic lobe development may, at least in part, involve deadpan and asense mediated regulation of the cyclin dependent kinase inhibitor gene dacapo. genesis 26:77-85, 2000.
authors.affiliation: Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA.
authors.forename: K
authors.initials: K
authors.lastname: Wallace
authors.forename: T H
authors.initials: TH
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Vaessin
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002455:Cell Division / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs / Q000502:physiology*; D017403:In Situ Hybridization; D019476:Insect Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D007814:Larva; D008938:Mitosis / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D009687:Nuclear Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology*; D009899:Optic Lobe, Nonmammalian / Q000254:growth & development* / Q000378:metabolism; D010641:Phenotype
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D018844:Cyclin-Dependent Kinases; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; C407353:ase protein, Drosophila; C103336:dap protein, Drosophila; C078020:Dpn protein, Drosophila