title: Medical treatment of a grossly enlarged adenomyotic uterus with the levonorgestrel-releasing intrauterine system.
abstract: Adenomyosis is an important cause of menorrhagia. Besides hysterectomy, the treatment options for adenomyosis have been limited. Presented here is the successful treatment of adenomyosis in a woman presenting with menorrhagia, dysmenorrhea, and an enlarging uterus, for whom conservative therapy initiated with mefenamic acid was unsatisfactory. The patient had insertion of the levonorgestrel-releasing intrauterine system (LNG-IUS). A marked decrease in uterine size occurred within 12 months of insertion accompanied by resolution of the menorrhagia and dysmenorrhea. Thus, the LNG-IUS is a viable option and represents a real advance in the treatment of adenomyosis.
authors.affiliation: Department of Obstetrics and Gynaecology, National University Hospital, Singapore, Singapore.
authors.forename: Y F
authors.initials: YF
authors.lastname: Fong
authors.forename: K
authors.initials: K
authors.lastname: Singh
mesh_terms: D000328:Adult; D000075202:Contraindications; D004343:Drug Implants; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008305:Malignant Hyperthermia; D008595:Menorrhagia / Q000209:etiology; D045167:Progesterone Congeners / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D014592:Uterine Hemorrhage / Q000139:chemically induced; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
chemical_list: D004343:Drug Implants; D045167:Progesterone Congeners; D016912:Levonorgestrel