title: [Dual fluorescence in situ hybridization analysis of synovial sarcoma].
abstract: Synovial sarcoma have (about in 95% of the cases) the specific and characteristic reciprocal chromosomal translocation t(X; 18) (p11.2; q 11.2). Application of dual-colour fluorescence in situ hybridization (FISH) on interphase nuclei to identify the specific translocation has a diagnostic importance for daily pathological practice. For visualisation of the translocated chromosomal fragments of synovial sarcoma cells on imprint smears, chromosome X painting probes and chromosome 18 centromeric probes were used. Our present study indicates that the precise preoperative diagnosis of synovial sarcoma using dual-colour FISH is possible on smears and this possibility (to identify specific chromosomal translocations in soft tissue tumours) is a landmark in the preoperative diagnosis of soft tissue sarcomas.
authors.affiliation: Pathologiai Osztály, Haynal Imre Egészségtudományi Egyetem, Onkopathologiai és Citodiagnosztikai Tanszék, Budapest.
authors.forename: Z
authors.initials: Z
authors.lastname: Sápi
authors.forename: I
authors.initials: I
authors.lastname: Antal
authors.forename: A
authors.initials: A
authors.lastname: Túri
authors.forename: M
authors.initials: M
authors.lastname: Szendröi
authors.forename: M
authors.initials: M
authors.lastname: Bodó
mesh_terms: D000328:Adult; D005385:Fingers; D005528:Foot; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000601:surgery; D014178:Translocation, Genetic