Cancer: the emerging molecular biology.
Discoveries at the molecular level have greatly increased our understanding of how a normal cell becomes a tumor cell, responsive only to growth signals. Cancer emerges as fundamentally genetic, representing mutations in protooncogenes and tumor suppressor genes arising from multiple "hits" over long spans of time. The knowledge portends abilities to interrupt the process at a precancerous stage.
Ross
D W
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Department of Pathology, University of North Carolina at Chapel Hill, USA.
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011230:Precancerous Conditions / Q000235:genetics; D011519:Proto-Oncogenes / Q000235:genetics