Surface-based DNA computing operations: DESTROY and READOUT.
DNA computing on surfaces is where complex combinatorial mixtures of DNA molecules are immobilized on a substrate and subsets are tagged and enzymatically modified (DESTROY) in repeated cycles of the DNA computation. A restriction enzyme has been chosen for the surface DESTROY operation. For the READOUT operation, both cycle sequencing and PCR amplification followed by addressed array hybridization were studied to determine the DNA sequences after the computations.
Wang
L
L
Department of Chemistry, University of Wisconsin-Madison, 53706, USA. lwang@chem.wisc.edu
Liu
Q
Q
Frutos
A G
AG
Gillmor
S D
SD
Thiel
A J
AJ
Strother
T C
TC
Condon
A E
AE
Corn
R M
RM
Lagally
M G
MG
Smith
L M
LM
D000818:Animals; D019295:Computational Biology; D003198:Computer Simulation; D004247:DNA / Q000032:analysis*; D006801:Humans
D004247:DNA