Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis.
Seven new compounds (1-6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3-6 showed moderate in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity.
Wellington
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KD
Department of Chemistry, and School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.
Cambie
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RC
Rutledge
P S
PS
Bergquist
P R
PR
D000818:Animals; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification*; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*; D013057:Spectrum Analysis
D010080:Oxazoles; D010455:Peptides