title: [Prenatal and postnatal transplantation of hematopoietic stem cells in children with primary immunodeficiency].
abstract: Primary immunodeficiencies are inherited diseases characterized by impaired immune responses. In case of severe impairment of immunity bone marrow transplantation is the only therapeutic option. The molecular defect is known for several primary immunodeficiencies allowing prenatal diagnosis. This paper summarizes the clinical experience treating these pathologies by bone marrow transplantation.
authors.affiliation: Clinica Pediatrica, Università degli Studi, Brescia.
authors.forename: F
authors.initials: F
authors.lastname: Porta
authors.forename: A
authors.initials: A
authors.lastname: Lanfranchi
authors.forename: R
authors.initials: R
authors.lastname: Verardi
authors.forename: E
authors.initials: E
authors.lastname: Mazzolari
authors.forename: U
authors.initials: U
authors.lastname: Verzeri
authors.forename: K
authors.initials: K
authors.lastname: Tettoni
authors.forename: A G
authors.initials: AG
authors.lastname: Ugazio
mesh_terms: D016465:Bone Marrow Purging; D016026:Bone Marrow Transplantation; D002648:Child; D005865:Gestational Age; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy*; D010586:Phagocytes; D016511:Severe Combined Immunodeficiency / Q000628:therapy; D014019:Tissue Donors; D019172:Transplantation Conditioning