title: [Percutaneous radiofrequency ablation of hepatic metastases. Preliminary experience].
abstract: OBJECTIVE
  To evaluate the efficiency of percutaneous radiofrequency ablation in the treatment of liver metastases.
  
  
  METHODS
  Eighteen patients with 31 liver metastases, mainly from colorectal cancer, 10 - 35 mm in diameter (m = 23), underwent 26 courses of percutaneous radiofrequency ablation. Fifteen patients had previously undergone hepatectomy, and 3 patients had contra-indications to surgery. Imaging guidance was ultrasound in 21 patients, CT in 4 (tumors not seen with ultrasound), and both in 1. A generator working at 450 KHz with a maximum output power of 150 W was used to treat each lesion for 18 - 20 min. Treatment was monitored with real time ultrasound.
  
  
  RESULTS
  Among the 12 patients followed more than 3 months, only one of the 24 treated lesions recurred after a mean follow up of 259 ¿ 109 days. Liver disease was controlled in 8 of the 12 patients after 90 - 509 days (m = 306). Among these 8 patients, 3 were tumor free after 559, 378 and 90 days, respectively; 2 died tumor free of non-tumoral disease (pulmonary embolism, digestive bleeding); 3 developed lung metastases treated with chemotherapy (n = 2) or surgery (n = 1). Three of the 12 patients had widespread hepatic tumor occurrence, and one patient died of these metastases. Six patients experienced mild skin burns, but no major complication was observed.
  
  
  CONCLUSIONS
  Radiofrequency ablation of hepatic metastases appears safe and promising in this preliminary experience. Further investigation is needed.
authors.affiliation: Département d'Imagerie Médicale, Institut Gustave-Roussy, Villejuif.
authors.forename: T
authors.initials: T
authors.lastname: De Baere
authors.forename: D
authors.initials: D
authors.lastname: Elias
authors.forename: M
authors.initials: M
authors.lastname: Ducreux
authors.forename: C
authors.initials: C
authors.lastname: Dromain
authors.forename: V
authors.initials: V
authors.lastname: Kuach
authors.forename: M
authors.initials: M
authors.lastname: Gamal El Din
authors.forename: A
authors.initials: A
authors.lastname: Sobotka
authors.forename: P
authors.initials: P
authors.lastname: Lasser
authors.forename: A
authors.initials: A
authors.lastname: Roche
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017115:Catheter Ablation; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies