title: The protective effects of meniscal transplantation on cartilage. An experimental study in sheep.
abstract: BACKGROUND
  Meniscal loss may result in arthritis. The aim of this study was to establish a simple operative method for meniscal transplantation in a large-animal model and to determine whether meniscal transplantation provides protection of the articular surfaces, whether meniscal allografts have the same protective effect as meniscal autogenous grafts, and whether there is any rejection phenomenon associated with meniscal allografts.
  
  
  METHODS
  Twenty-eight sheep were divided into four study groups, which were treated with (1) a sham operation (four sheep), (2) a meniscectomy (eight sheep), (3) a meniscal autogenous graft (eight sheep), or (4) a meniscal allograft (eight sheep). The meniscal transplant was secured with three suture anchors to the tibia. At four months after the operation, macroscopic and microscopic evaluations of the articular cartilage and the menisci of the sheep knees were performed in a blinded fashion.
  
  
  RESULTS
  The group treated with the sham operation had no cartilage damage and had normal meniscal tissue. The meniscectomies resulted in significant macroscopic and microscopic damage to the articular cartilage in the medial compartment. The mean score (and standard error of the mean) for macroscopic damage to the cartilage in the group treated with the meniscectomy was 6.5+/-0.8 points compared with 3.9+/-0.7 points in the group treated with the autogenous graft and 4.3+/-0.6 points in the group treated with the allograft (p<0.05). The size of the area of damaged articular cartilage was reduced by approximately 50 percent in both groups treated with a meniscal transplant compared with the group treated with the meniscectomy (p<0.05). There were no significant differences between the group treated with the autogenous graft and that treated with the allograft. The histological appearance of the meniscal autogenous grafts was within normal limits. Interestingly, all of the allografts had evidence of fibrinoid degeneration with areas of hypocellularity and cloning of chondroid cells.
  
  
  CONCLUSIONS
  These results suggest that meniscal transplantation provides noticeable although not complete protection against damage to the articular cartilage after a meniscectomy. The meniscal allografts were just as effective in providing this protection as were the meniscal autogenous grafts.
authors.affiliation: Department of Orthopaedic Surgery, Orthopaedic Research Institute, St. George Hospital Campus, University of New South Wales, Kogarah, Sydney, Australia.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Szomor
authors.forename: T E
authors.initials: TE
authors.lastname: Martin
authors.forename: F
authors.initials: F
authors.lastname: Bonar
authors.forename: G A
authors.initials: GA
authors.lastname: Murrell
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology*; D007719:Knee Joint / Q000473:pathology*; D008592:Menisci, Tibial / Q000473:pathology / Q000601:surgery / Q000637:transplantation*; D012756:Sheep; D013977:Tibia / Q000601:surgery; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous