title: Progress in understanding structure-function relationships in respiratory chain complex II.
abstract: Complex II (succinate:quinone oxidoreductase) of aerobic respiratory chains oxidizes succinate to fumarate and passes the electrons directly into the quinone pool. It serves as the only direct link between activity in the citric acid cycle and electron transport in the membrane. Finer details of these reactions and interactions are but poorly understood. However, complex II has extremely similar structural and catalytic properties to quinol:fumarate oxidoreductases of anaerobic organisms, for which X-ray structures have recently become available. These offer new insights into structure-function relationships of this class of flavoenzymes, including evidence favoring protein movement during catalysis.
authors.affiliation: Molecular Biology Division, D.V.A. Medical Center and Department of Biochemistry and Biophysics, University of California, 4150 Clement Street, San Francisco, CA, USA. baca@itsa.ucsf.edu
authors.forename: B A
authors.initials: BA
authors.lastname: Ackrell
mesh_terms: D002384:Catalysis; D004579:Electron Transport; D042963:Electron Transport Complex II; D004926:Escherichia coli / Q000201:enzymology; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism*; D010088:Oxidoreductases / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation; D020836:Protein Structure, Quaternary; D017433:Protein Structure, Secondary; D013385:Succinate Dehydrogenase / Q000737:chemistry* / Q000378:metabolism*; D016968:Wolinella / Q000201:enzymology
chemical_list: D007506:Iron-Sulfur Proteins; D009097:Multienzyme Complexes; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase