Important hints in behavioural teratology of rodents.
The paper deals with the most important items regarding the improvement of quality of experimental procedures when testing drug effects on behaviour and development of commonly-used rodent species. Current-used test procedures for immature and adult rodents exposed early developmentally are briefly described and recent advances and difficulties in their hands-on interpretation are highlighted. Comparability of measures in human and animals for drug-effect assessment is also shortly discussed. It is then stressed that studies on rodents carried out in seminaturalistic and naturalistic settings may offer a highly profitable direction for future research in behavioural teratology and toxicology. A final paragraph is dedicated to the bioethical aspects arisen from the use of large number of rodents subjects in behavioural testing.
Alleva
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Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanità, Roma, Viale Regina Elena 299, Italy. alleva@iss.it
Sorace
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A
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D012107:Research Design; D012377:Rodentia / Q000502:physiology*; D018600:Teratology / Q000379:methods*