On the relative sample size required for multiple comparisons.
Multiple comparisons are commonly made in epidemiologic and genetic research. How to appropriately adjust for multiple comparisons remains a controversial issue. This note demonstrates, however, that large increases in the number of comparisons has a limited effect on the sample size required to maintain an experimentwise alpha-level. In particular, the relative sample size required increases only linearly with the logarithm of the number of comparisons made.
Witte
J S
JS
Department of Epidemiology and Biostatistics, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland OH 44109-1998, USA. witte@darwin.cwru.edu
Elston
R C
RC
Cardon
L R
LR
D015233:Models, Statistical; D012107:Research Design; D018401:Sample Size