title: The changes of serum soluble intercellular adhesion molecule-1 after systemic steroid treatment in vitiligo.
abstract: Cell surface adhesion molecules are thought to play an important role in establishing intercellular contacts that are necessary for immunological reactions. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a crucial adhesion molecule in mediating cell to cell adhesion during inflammatory responses, including non-MHC-restricted cytotoxicity. In this study, the sICAM-1 levels of ten healthy control subjects and seven generalized active vitiligo patients were measured by ELISA. The sICAM-1 levels were also correlated with the clinical courses in 33 patients with active vitiligo, who received systemic steroid treatment for 3 months. The average serum level of sICAM-1 was significantly higher in patients with active vitiligo than in the healthy control subjects. The sICAM-1 levels significantly decreased after systemic steroid treatment in the clinically improved group. These results suggest that immune activation is involved in active vitiligo and that changes of sICAM-1 levels can be a marker in the course of vitiliginous lesions.
authors.affiliation: Department of Dermatology, College of Medicine, Seoul National University, South Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Hwang
authors.forename: J S
authors.initials: JS
authors.lastname: Ahn
authors.forename: S D
authors.initials: SD
authors.lastname: Kim
authors.forename: J G
authors.initials: JG
authors.lastname: Lim
authors.forename: Y G
authors.initials: YG
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.forename: K C
authors.initials: KC
authors.lastname: Park
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D013256:Steroids / Q000627:therapeutic use*; D014820:Vitiligo / Q000097:blood* / Q000188:drug therapy
chemical_list: D013256:Steroids; D018799:Intercellular Adhesion Molecule-1