Modulating chemokines: more lessons from viruses.
Chemokines are crucial effector molecules involved in orchestrating the host inflammatory response against invading pathogens. Viruses have devised several strategies for exploiting or neutralizing chemokines or their receptors to further their own propagation or elude host defenses. Insight into strategies used by viruses to modulate chemokines might help generate novel approaches for treating viral diseases and chemokine-mediated inflammatory disorders.
Lalani
A S
AS
Howard Hughes Medical Institute, Dept of Microbiology and Immunology, University of California San Francisco, 94143-0414, USA. lalani@itsa.ucsf.edu
Barrett
J W
JW
McFadden
G
G
D000818:Animals; D018925:Chemokines / Q000378:metabolism*; D005814:Genes, Viral; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D016366:Open Reading Frames; D019707:Receptors, Chemokine / Q000378:metabolism*; D014764:Viral Proteins / Q000737:chemistry / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology* / Q000503:physiopathology; D014780:Viruses / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity
D018925:Chemokines; D019707:Receptors, Chemokine; D014764:Viral Proteins