Leukoencephalopathy in multiple myeloma: two case reports.
BACKGROUND
No case of leukoencephalopathy has been reported associated with multiple myeloma.


METHODS
We report on two patients with a very rare association of leukoencephalopathy and multiple myeloma revealed by cognitive impairment.


RESULTS
Chemotherapy has improved neurological and biological signs. Radiological abnormalities have been stabilized.


CONCLUSIONS
The authors suggest that leukoencephalopathy is probably a direct cerebral expression of malignant gammopathy.
Lebrun
C
C
Service de Neurologie, Hôpital Pasteur, Nice, France.
Chanalet
S
S
Frenay
M
M
Chatel
M
M
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D011115:Polyneuropathies / Q000188:drug therapy / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan; D011241:Prednisone