Leukocyte migration: scent of the T zone.
Recent studies show that the chemokine receptor CCR7 helps T lymphocytes and dendritic cells to navigate into the T-cell zone of lymphoid organs. Furthermore, down-modulation of CCR7 redirects some activated T cells from these zones into other lymphoid tissue compartments.
Cyster
J G
JG
Department of Microbiology and Immunology, University of California San Francisco 94143-0414, USA. cyster@itsa.ucsf.edu
D000818:Animals; D054415:Chemokine CCL19; D054421:Chemokine CCL21; D019742:Chemokines, CC / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D002634:Chemotaxis, Leukocyte; D003713:Dendritic Cells / Q000166:cytology*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000473:pathology; D007156:Immunologic Memory; D007801:Langerhans Cells / Q000166:cytology; D008211:Lymphocyte Cooperation; D008221:Lymphoid Tissue / Q000166:cytology; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D054400:Receptors, CCR7; D019707:Receptors, Chemokine / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology*
C515460:CCL19 protein, human; C515478:CCL21 protein, human; C515370:CCR7 protein, human; C515461:Ccl19 protein, mouse; C515479:Ccl21c protein, mouse; C515371:Ccr7 protein, mouse; D054415:Chemokine CCL19; D054421:Chemokine CCL21; D019742:Chemokines, CC; D054400:Receptors, CCR7; D019707:Receptors, Chemokine