Can Reed-Sternberg cells of classic Hodgkin's disease be considered B-cells?
During the last twenty years, the issue of the nature of Reed-Sternberg (RS) cells of Hodgkin's disease (HD) has been addressed by multiple methodological approaches. In recent times, a major insight into HD has been obtained through molecular studies of isolated cells which have proven the clonal nature of HD. In parallel to molecular investigations some novel biologic markers specifically associated with the different stages of mature B-cells have helped to define the cellular origin of HD. This review deals with histological features of HD and summarizes recent results from molecular and immunohistochemical studies focusing on the origin and the stage of differentiation of RS cells.
Carbone
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A
Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, 33081, Italy. acarbone@ets.it
Gloghini
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A
Gaidano
G
G
D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D019013:CD40 Antigens / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D006689:Hodgkin Disease / Q000145:classification / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000378:metabolism; D008954:Models, Biological; D011509:Proteoglycans / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6; D016539:Reed-Sternberg Cells / Q000378:metabolism / Q000473:pathology*; D053667:Syndecans; D014157:Transcription Factors / Q000378:metabolism
D019013:CD40 Antigens; D004268:DNA-Binding Proteins; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D053667:Syndecans; D014157:Transcription Factors