Predictors of cardiovascular response to smoked cocaine in humans.
The purpose of this study was to examine the predictors of heart rate and blood pressure changes following cocaine administration. Sixty-two smoked cocaine users received a single 0.4 mg/kg dose of smoked cocaine. Male sex, African American race, higher body weight and current marijuana use predicted a greater cardiovascular response to cocaine. In contrast, higher baseline blood pressure, heart rate, amount and frequency of current cocaine use and presence of current cocaine snorting predicted a diminished cardiovascular response to cocaine. Whether these predictors of the cardiovascular response to smoked cocaine in the laboratory also predict cardiovascular complications from long-term cocaine use needs to be studied further.
Sofuoglu
M
M
Department of Psychiatry and Pharmacology, Health Science Center, University of Minnesota, Minneapolis 55415, USA. sofuo001@maroon.tc.umn.edu
Nelson
D
D
Dudish-Poulsen
S
S
Lexau
B
B
Pentel
P R
PR
Hatsukami
D K
DK
D000280:Administration, Inhalation; D000328:Adult; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D016578:Crack Cocaine / Q000008:administration & dosage; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male
D016578:Crack Cocaine