title: [Indications of cerebral micro-hemorrhage in MRI. Comparative histological findings and possible clinical significance].
abstract: Increased use of gradient echo T2*-weighted gradient echo sequences in magnetic resonance imaging (MRI) of patients suffering from primary ICH called attention to foci of signal loss which were suggested to represent remnants of cerebral microbleeds. In a post mortem correlative MR and histopathological study we provide support for this notion. We found areas of signal loss on gradient echo T2*-weighted sequences in 7 out of 11 brains of patients who had died of intracerebral hematoma. Histopathologically, these areas represented hemosiderin deposits indicating previous extravasation of blood. To provide data about the prevalence of these MRI findings in a healthy elderly population a subgroup of participants of the Austrian Stroke Prevention Study was analyzed. We detected foci of signal loss on gradient echo T2*-weighted sequences in 18 out of 280 volunteers (6.4%). MR-based evidence of previous microbleeds may indicate a potentially higher risk of suffering from intracerebral bleeding which could have therapeutic implications for the treatment of acute stroke and for secondary prevention. This hypothesis will have to be tested in future prospective trials.
authors.affiliation: Universitätsklinik für Neurologie der Karl-Franzens Universität, Graz.
authors.forename: G
authors.initials: G
authors.lastname: Roob
authors.forename: R
authors.initials: R
authors.lastname: Kleinert
authors.forename: T
authors.initials: T
authors.lastname: Seifert
authors.forename: A
authors.initials: A
authors.lastname: Lechner
authors.forename: P
authors.initials: P
authors.lastname: Kapeller
authors.forename: G
authors.initials: G
authors.lastname: Kleinert
authors.forename: R
authors.initials: R
authors.lastname: Schmidt
authors.forename: F
authors.initials: F
authors.lastname: Fazekas
authors.forename: H P
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D017352:Echo-Planar Imaging; D005260:Female; D006485:Hemosiderin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000473:pathology; D007089:Image Enhancement; D020300:Intracranial Hemorrhages / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012680:Sensitivity and Specificity
chemical_list: D006485:Hemosiderin