Heterogeneity of T-lymphocyte function in primary progressive multiple sclerosis: relation to magnetic resonance imaging lesion volume.
We found that in vitro migration and interferon-gamma production by lymphocytes derived from primary progressive multiple sclerosis patients preselected on the basis of a high T2-weighted lesion volume (>10 cm3) on magnetic resonance imaging, were increased compared with that in primary progressive multiple sclerosis patients with a low T2-weighted lesion volume (<3 cm3) and controls. Whether the heterogeneity of immune function within the primary progressive population will correlate with response to therapy remains to be established.
Prat
A
A
Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Quebec, Canada.
Pelletier
D
D
Duquette
P
P
Arnold
D L
DL
Antel
J P
JP
D000328:Adult; D001921:Brain / Q000473:pathology*; D002465:Cell Movement; D014644:Genetic Variation; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*
D007371:Interferon-gamma