title: Newer intranasal migraine medications.
abstract: Two new intranasal migraine medications, sumatriptan and dihydroergotamine mesylate, may offer specific advantages for patients who are seeking alternatives to various oral or parenteral migraine abortive therapies. Placebo-controlled clinical studies demonstrate that both intranasal forms are effective in relieving migraine headache pain, but published clinical trial information comparing these two intranasal medications with current abortive therapies is lacking. Both agents are generally well tolerated by patients, with the exception of mild, local adverse reactions of the nose and throat.
authors.affiliation: Iowa Lutheran Hospital Family Practice Residency, Des Moines, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Logemann
authors.forename: L M
authors.initials: LM
authors.lastname: Rankin
mesh_terms: D000281:Administration, Intranasal; D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D004087:Dihydroergotamine / Q000008:administration & dosage*; D006207:Half-Life; D006801:Humans; D007211:Indoles / Q000008:administration & dosage; D008881:Migraine Disorders / Q000188:drug therapy*; D010080:Oxazoles / Q000008:administration & dosage; D023303:Oxazolidinones; D010880:Piperidines / Q000008:administration & dosage; D012008:Recurrence; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*; D018170:Sumatriptan / Q000008:administration & dosage*; D014230:Triazoles / Q000008:administration & dosage; D014363:Tryptamines
chemical_list: D018712:Analgesics, Non-Narcotic; D007211:Indoles; D010080:Oxazoles; D023303:Oxazolidinones; D010880:Piperidines; D017366:Serotonin Receptor Agonists; D014230:Triazoles; D014363:Tryptamines; C089750:zolmitriptan; D004087:Dihydroergotamine; C093622:rizatriptan; D018170:Sumatriptan; C106783:naratriptan