title: Elasticity reconstruction from experimental MR displacement data: initial experience with an overlapping subzone finite element inversion process.
abstract: The determination of the elastic property distribution in heterogeneous gel samples with a finite element based reconstruction scheme is considered. The algorithm operates on small overlapping subzones of the total field to allow for a high degree of spatial discretization while maintaining computational tractability. By including a Maxwellian-type viscoelastic property in the model physics and optimizing the spatial distribution of this property in the same manner as elasticity, a Young's modulus image is obtained which reasonably reflects the true distribution within the gel. However, the image lacks the clarity and accuracy expected based on simulation experience. Preliminary investigations suggest that transient effects in the data are the cause of a significant mismatch between the inversion model, which assumes steady-state conditions, and the actual displacements as measured by a phase contrast MR technique.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Van Houten
authors.forename: J B
authors.initials: JB
authors.lastname: Weaver
authors.forename: M I
authors.initials: MI
authors.lastname: Miga
authors.forename: F E
authors.initials: FE
authors.lastname: Kennedy
authors.forename: K D
authors.initials: KD
authors.lastname: Paulsen
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D004548:Elasticity; D005782:Gels; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data*; D019047:Phantoms, Imaging; D014783:Viscosity
chemical_list: D005782:Gels