Treatment of edematous disorders with diuretics.
Generalized edema results from alterations in renal sodium homeostasis that ultimately result in an expansion of extracellular fluid volume and accumulation of interstitial fluid. The common edematous disorders include congestive heart failure, cirrhosis, nephrotic syndrome, and renal insufficiency. The abnormalities of sodium homeostasis contributing to edema formation in each condition are discussed. Management of volume homeostasis, with an emphasis on the role of diuretic therapy, is reviewed.
Rasool
A
A
Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Palevsky
P M
PM
D004232:Diuretics / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D005355:Fibrosis / Q000188:drug therapy / Q000503:physiopathology; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000503:physiopathology; D051437:Renal Insufficiency / Q000188:drug therapy / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism
D004232:Diuretics; D014867:Water; D012964:Sodium