[The relationship of polymorphism of angiotensinogen and angiotensin converting enzyme with essential hypertension].
OBJECTIVE
In order to investigate the candidate genes for essential hypertension(EH), the authors determined the frequencies of M235T allele variation in exon 2 of angiotensinogen(AGT) gene and angiotensin converting enzyme (ACE) gene in 95 normotensives and 87 hypertensives in Chinese.


METHODS
Polymerase chain reaction combined with restriction enzyme digestion was used to detect the variation AGT gene while PCR was used to determine ACE gene polymorphism.


RESULTS
T235 allele frequency was significantly higher in hypertensive patients than in controls (0.45 vs 0.33, P<0. 05) and it was noticeably higher in male hypertensives. The frequency of ACE D allele in the EH patients with family history was higher than that in controls(0.59 vs 0.41,P<0.05).


CONCLUSIONS
The variation of AGT gene was involved in the pathogenesis of hypertension, especially in male. The ACE D allele was associated with EH with family history.
Ye
Q
Q
Institute of Hypertension Research, The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, 350005 P.R. China. HWMYeq@pub3.fz.fj.cn
Wu
K
K
Xie
L
L
Zeng
K
K
Lin
J
J
Lin
C
C
D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A