title: Intraosseous squamous cell carcinoma arising in association with a squamous odontogenic tumour of the mandible.
abstract: We report a rare occurrence of intraosseous squamous cell carcinoma (SCC) arising in association with a squamous odontogenic tumour (SOT), which had not previously been documented in the literature. A 53-year-old man had, for 5 years, a well-demarcated radiolucency attached to the impacted third molar of the mandible. The enucleated specimen had a characteristic pattern of SOT, but in which a few epithelial islands showed atypical features suggestive of SCC. Intense p53-, proliferating cell nuclear antigen- and Ki-67-positive cells were detected in carcinoma areas. Within 2 months, aggressive bone destruction showing typical findings of intraosseous SCC appeared. The present tumour is presumably a malignant variant of SOT.
authors.affiliation: Department of Oral Surgery, Saitama Medical Center, Saitama Medical School, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Ide
authors.forename: T
authors.initials: T
authors.lastname: Shimoyama
authors.forename: N
authors.initials: N
authors.lastname: Horie
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
mesh_terms: D000564:Ameloblastoma / Q000473:pathology*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009378:Neoplasms, Multiple Primary / Q000473:pathology*