title: [Fatal poisoning with Letigen].
abstract: The anorexic agent Letigen, which contains 200 mg coffeine and 20 mg ephedrine, has been extensively used during the last decade. The case report describes a 19 year-old woman who ingested 50 Letigen tablets in a suicidal attempt. She developed severe toxic manifestations from the heart, CNS, muscles, liver and kidneys leading to several cardiac arrests, and died subsequently of cerebral oedema and incarceration on the fourth day of hospitalization. Because of the potentially life-threatening intoxication following an overdose, prescription of Letigen must be carefully administered.
authors.affiliation: H:S Bispebjerg Hospital, klinisk biokemisk, kardiologisk og anaestesiologisk afdeling. Hedetoft@dadlnet.dk
authors.forename: C
authors.initials: C
authors.lastname: Hedetoft
authors.forename: C H
authors.initials: CH
authors.lastname: Jensen
authors.forename: M R
authors.initials: MR
authors.lastname: Christensen
authors.forename: O
authors.initials: O
authors.lastname: Christensen
mesh_terms: D000328:Adult; D001067:Appetite Depressants / Q000506:poisoning*; D002110:Caffeine / Q000506:poisoning*; D000697:Central Nervous System Stimulants / Q000506:poisoning*; D004338:Drug Combinations; D062787:Drug Overdose; D004809:Ephedrine / Q000506:poisoning*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013405:Suicide
chemical_list: D001067:Appetite Depressants; D000697:Central Nervous System Stimulants; D004338:Drug Combinations; D002110:Caffeine; D004809:Ephedrine