title: 5-Lipoxygenase-derived oxylipins from the red alga Rhodymenia pertusa.
abstract: The lipid extract of the temperate red alga Rhodymenia pertusa has yielded four eicosanoid metabolites, three of which are new natural products. Using principally NMR and MS techniques, their structures were deduced as 5R,6S-dihydroxy-7(E),9(E),11(Z),14(Z)-eicosatetraenoic acid (5R,6S-diHETE), 5R*,6S*-dihydroxy-7(E),9(E),11(Z),14(Z),17(Z)-eicosapentaenoic acid (5R*,6S*-diHEPE), 5-hydroxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-HETE), 5-hydroxy-6(E),8(Z),11(Z),14(Z),17(Z)-eicosapentaenoic acid (5-HEPE). The co-occurrence of these metabolites strongly suggests that R. pertusa contains a unique 5R-lipoxygenase system acting on both arachidonic and eicosapentaenoic acids.
authors.affiliation: College of Pharmacy, Oregon State University, Corvllis 97331, USA.
authors.forename: Z D
authors.initials: ZD
authors.lastname: Jiang
authors.forename: S O
authors.initials: SO
authors.lastname: Ketchum
authors.forename: W H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D015777:Eicosanoids / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000461:Rhodophyta / Q000737:chemistry* / Q000378:metabolism
chemical_list: D015777:Eicosanoids; D001094:Arachidonate 5-Lipoxygenase