[The initial tone of arteries determines the magnitude of depressor responses caused by nitroglycerin].
The correlation analysis revealed a direct (within the range 80 to 120 mm Hg) further transforming into a reverse (within the range 121 to 160 mm Hg) dependence of the blood pressure depressor shifts on the initial mean arterial pressure in anaesthetised rats. Within the physiological range of arterial pressure (70 to 130 mm Hg) there is no difference in responses to nitro-glycerine from their initial values. The mechanisms of dependence of the systemic vascular responses on initial tone of arterial vessels, are discussed.
Osadchiĭ
L I
LI
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
Balueva
T V
TV
Sergeev
I V
IV
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005263:Femoral Artery / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009129:Muscle Tonus / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D005996:Nitroglycerin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D000804:Angiotensin II; D005996:Nitroglycerin