title: Hepatosplenic B-cell lymphoma associated with hemophagocytic syndrome: a case report.
abstract: While T-cell non-Hodgkin's lymphoma (NHL) associated with hemophagocytic syndrome (HPS) has been frequently observed, B-cell NHL associated with HPS has been rarely reported. We report a case of hepatosplenic B-cell lymphoma associated with HPS in a 41-year-old woman who presented with fever of unknown origin. An abdominal CT scan revealed splenomegaly with focal splenic infarction. Splenectomy and a liver wedge biopsy showed sinusoidal-pattern infiltration of medium to large tumor cells with positive reaction to a B-lymphocyte marker. Findings on bone marrow examination showed proliferation of histiocytes with avid hemophagocytosis.
authors.affiliation: Department of Internal Medicine, National University Medical School, Kwangju, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Kwon
authors.forename: J J
authors.initials: JJ
authors.lastname: Lee
authors.forename: I J
authors.initials: IJ
authors.lastname: Chung
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: M R
authors.initials: MR
authors.lastname: Park
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: C S
authors.initials: CS
authors.lastname: Park
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001854:Bone Marrow Cells / Q000473:pathology; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013160:Splenic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013163:Splenomegaly / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor