title: Anti-cholestatic activity of HD-03, a herbal formulation in thioacetamide (TAA)-induced experimental cholestasis.
abstract: In the present study HD-03, a herbal formulation was investigated for its anti-cholestatic activity in TAA-induced cholestasis in anaesthetized guinea pigs. Administration of TAA at a dose of 100 mg/kg body wt significantly reduced the bile flow, bile acid and bile salt excretion. Pretreatment with HD-03 at a dose of 750 mg/kg body wt per orally for 15 days in guinea pigs significantly prevented thioacetamide-induced changes in bile flow, bile acids and bile salts excretion. Thus, HD-03 can serve as a potent choleretic and anti-cholestatic agent.
authors.affiliation: R & D Centre, The Himalaya Drug Co., Makali, Bangalore, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
authors.forename: M V
authors.initials: MV
authors.lastname: Venkataranganna
authors.forename: S
authors.initials: S
authors.lastname: Gopumadhavan
authors.forename: R
authors.initials: R
authors.lastname: Sundaram
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000502:physiology; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000494:pharmacology*; D002779:Cholestasis / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D006168:Guinea Pigs; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D010946:Plants, Medicinal; D013853:Thioacetamide / Q000633:toxicity
chemical_list: D002756:Cholagogues and Choleretics; C119007:HD 03 polyherbal; D010936:Plant Extracts; D013853:Thioacetamide