The effect of air pollution on exhaled nitric oxide of atopic and nonatopic subjects.
Levels of exhaled nitric oxide (NO) were determined in well-characterized atopic and nonatopic subjects on 4 days with a different level of outdoor air pollution. The two groups matched well regarding spirometric values, i.e., no difference with regard to FEV(1), FVC, and peak flow. On the 4 test days asymptomatic atopic subjects exhaled 1.5- to 2.4-fold higher levels of NO compared with nonatopic subjects. In both groups the increase in exhaled NO in response to air pollution was similar (2.5 times maximal increase, P < 0.01). In conclusion, atopic subjects exhale higher levels of NO compared with nonatopic subjects, but respond to a similar degree to increased levels of air pollution.
van Amsterdam
J G
JG
Laboratory of Health Effects Research, Laboratory for Pathology and Immunobiology, Bilthoven, 3720 BA, The Netherlands.
Hollander
A
A
Snelder
J D
JD
Fischer
P H
PH
van Loveren
H
H
Vos
J G
JG
Opperhuizen
A
A
Steerenberg
P A
PA
D000328:Adult; D016902:Air Pollution, Indoor; D000818:Animals; D000830:Animals, Laboratory; D001944:Breath Tests; D005260:Female; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D017056:Medical Laboratory Personnel; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*; D012123:Pulmonary Ventilation / Q000502:physiology*; D012016:Reference Values; D012882:Skin Tests; D014797:Vital Capacity
D009569:Nitric Oxide