cDNA cloning of human muskelin and localisation of the muskelin (MKLN1) gene to human chromosome 7q32 and mouse chromosome 6 B1/B2 by physical mapping and FISH.
Muskelin is a novel intracellular protein, identified in mouse cells, that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin-1. We report that human muskelin is 98% identical with mouse muskelin at the amino acid level. The human muskelin gene is located at 7q32. The mouse muskelin gene maps syntenically at chromosome 6 B1/B2.
Adams
J C
JC
MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, UK. dmcbjca@ucl.ac.uk
Zhang
L
L
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D015815:Cell Adhesion Molecules; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D003001:Cloning, Molecular; D017124:Conserved Sequence; D018076:DNA, Complementary / Q000235:genetics; D020224:Expressed Sequence Tags; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D020161:Physical Chromosome Mapping; D011506:Proteins / Q000737:chemistry / Q000235:genetics*
D015815:Cell Adhesion Molecules; D018076:DNA, Complementary; D047908:Intracellular Signaling Peptides and Proteins; C503019:MKLN1 protein, human; C503020:Mkln1 protein, mouse; D011506:Proteins