title: Who benefits from treatment and rehabilitation in a stroke Unit? A community-based study.
abstract: OBJECTIVE
  The beneficial effects of treatment and rehabilitation of patients with acute stroke in a dedicated stroke unit (SU) are well established. We wanted to examine if these effects are limited to certain groups of patients or if they apply to all patients independent of age, sex, comorbidity, and initial stroke severity.
  
  
  METHODS
  This was a community-based study of outcome in 1241 consecutive stroke patients from 2 communities in Copenhagen: In one (Frederiksberg), treatment and rehabilitation were given in general neurological and medical wards (GW), and in the other (Bispebjerg) in one single large SU. Outcome measures were initial, 1-year, and 5-year mortality rates, a poor outcome (initial death or discharge to a nursing home), and length of hospital stay (LOHS). Multivariate regression analyses were used to examine the independent effect of SU treatment on the various subgroups.
  
  
  RESULTS
  The relative risks of initial death, poor outcome, and 1-year and 5-year mortality rates were reduced by 40% on average in patients treated in the SU compared with the GW. A beneficial effect of SU treatment was observed regardless of the patient's age, sex, comorbidity, and initial stroke severity. Those who benefited most appeared to be the patients with the most severe strokes (poor outcome: OR 0.17; 95% CI 0.05 to 0.58). Those who benefited least were patients with mild or moderate strokes (poor outcome: OR 0.66; 95% CI 0.41 to 0.98) and patients <75 years of age (poor outcome: OR 0.66; 95% CI 0.36 to 1.19). LOHS was reduced by 2 to 3 weeks in all who had their treatment in the SU except in patients with the most severe strokes. LOHS in these patients was similar to LOHS in the GW.
  
  
  CONCLUSIONS
  A beneficial effect of treatment in a SU is achieved in completely unselected patients independent of their age, sex, comorbidity, and stroke severity. Those who had the most severe strokes appeared to benefit most. All patients with acute stroke should therefore have access to treatment and rehabilitation in a dedicated SU.
authors.affiliation: Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark. hsj@dadlnet.dk
authors.forename: H S
authors.initials: HS
authors.lastname: Jorgensen
authors.forename: L P
authors.initials: LP
authors.lastname: Kammersgaard
authors.forename: J
authors.initials: J
authors.lastname: Houth
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: H O
authors.initials: HO
authors.lastname: Raaschou
authors.forename: K
authors.initials: K
authors.lastname: Larsen
authors.forename: P
authors.initials: P
authors.lastname: Hübbe
authors.forename: T S
authors.initials: TS
authors.lastname: Olsen
mesh_terms: D000208:Acute Disease; D000368:Aged; D003153:Community Health Services / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome