title: In vitro bioactivity of glass and glass-ceramics of the 3CaO x P2O5-CaO x SiO2-CaO x MgO x 2SiO2 system.
abstract: A glass of nominal composition (wt%) 40.0 CaO-34.5 SiO2-16.5 P2O5-8.5 MgO-0.5 CaF2 has been obtained (G13). The glass showed in vitro bioactivity evidenced by the formation on its surface of a calcium phosphate-rich layer when soaked in a solution with ionic composition analogous to human plasma. By thermal treatments of G13, a glass-ceramic (GC13) containing apatite, diopside, althausite and akermanite as crystalline phases was developed. GC13 as-made did not show in vitro bioactivity. However, after chemical treatment of GC13 with 1 M HCl (GC13-HCl), the in vitro studies showed the formation of an apatite-like layer covering certain areas of the material surface. The influence of both chemical and morphological factors on the in vitro bioactivity has been studied.
authors.affiliation: Departmento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
authors.forename: A J
authors.initials: AJ
authors.lastname: Salinas
authors.forename: J
authors.initials: J
authors.lastname: Román
authors.forename: M
authors.initials: M
authors.lastname: Vallet-Regí
authors.forename: J M
authors.initials: JM
authors.lastname: Oliveira
authors.forename: R N
authors.initials: RN
authors.lastname: Correia
authors.forename: M H
authors.initials: MH
authors.lastname: Fernandes
mesh_terms: D017610:Calcium Compounds / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008277:Magnesium Oxide / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010087:Oxides / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D017610:Calcium Compounds; D010087:Oxides; D010710:Phosphates; D008277:Magnesium Oxide; D012822:Silicon Dioxide; C016538:lime