title: Effect of a vegetable-protein-rich polymeric diet treatment on body composition and energy metabolism in inactive Crohn's disease.
abstract: OBJECTIVE
  Since malnutrition and lactose intolerance are frequently reported in Crohn's disease (CD), we evaluated the differences in terms of compliance-to-treatment and nutritional status in inactive CD patients after two different treatments using either a standard polymeric diet or a vegetable-protein-rich and lactose-free diet.
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  Forty CD patients with inactive disease were randomly divided into two groups. Group A (10 men; aged 33.9+/-7.2 years; BMI, 21.8+/-1.7 kg/m2) received a conventional polymeric enteral diet, while group B (10 men; aged 35.6+/-6.8 years; BMI, 21.4+/-1.8 kg/m2) was administered a soy-rich and lactose-free polymeric diet, over a 4-week period.
  
  
  METHODS
  All the patients had a clinical and laboratory examination. Body composition was assessed by isotopic dilution and resting metabolic rate (RMR), and substrate oxidation rates were measured by indirect calorimetry.
  
  
  RESULTS
  Body weight significantly increased after treatment in both groups (A, P<0.05; and B, P<0.01), as well as fat-free mass (A, P<0.05; and B, P<0.05) and fat mass (A, P<0.05; and B, P<0.01). RMR slightly increased, although it did not reach statistical significance. Treatment did not influence substrate oxidation rates. Group B lactose-intolerant patients reported a greater compliance-to-treatment than those in group A.
  
  
  CONCLUSIONS
  This study showed that a polymeric enteral diet rich in vegetable protein and not containing milk protein, eaten at home, with no need for positioning a nasogastric tube, significantly improved body composition in inactive and lactose-intolerant CD patients, with no effect on energy metabolism, suggesting that it could be useful in improving nutritional status in these patients.
authors.affiliation: Institute of Internal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy. ecapristo@pelagus.it
authors.forename: E
authors.initials: E
authors.lastname: Capristo
authors.forename: G
authors.initials: G
authors.lastname: Mingrone
authors.forename: G
authors.initials: G
authors.lastname: Addolorato
authors.forename: A V
authors.initials: AV
authors.lastname: Greco
authors.forename: G
authors.initials: G
authors.lastname: Gasbarrini
mesh_terms: D000328:Adult; D001823:Body Composition; D002153:Calorimetry, Indirect; D003424:Crohn Disease / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D004734:Energy Metabolism; D005260:Female; D005526:Food, Formulated; D006801:Humans; D007787:Lactose Intolerance / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D008297:Male; D030262:Soybean Proteins / Q000008:administration & dosage*
chemical_list: D030262:Soybean Proteins