title: Gallstones in sickle cell disease: observations from The Jamaican Cohort study.
abstract: The prevalence, incidence, risk factors, clinical associations, and morbidity of gallstones were studied in 311 patients with homozygous sickle cell disease and 167 patients with sickle cell-hemoglobin C disease in a cohort study from birth. Gallstones developed in 96 patients with homozygous sickle cell disease and 18 patients with sickle cell-hemoglobin C disease; specific symptoms necessitating cholecystectomy occurred in only 7 patients with homozygous sickle cell disease.
authors.affiliation: Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, Jamaica.
authors.forename: T M
authors.initials: TM
authors.lastname: Walker
authors.forename: I R
authors.initials: IR
authors.lastname: Hambleton
authors.forename: G R
authors.initials: GR
authors.lastname: Serjeant
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D002648:Child; D002763:Cholecystectomy; D002769:Cholelithiasis / Q000150:complications / Q000453:epidemiology* / Q000601:surgery; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006450:Hemoglobin SC Disease / Q000453:epidemiology* / Q000401:mortality; D006720:Homozygote; D006801:Humans; D015994:Incidence; D007563:Jamaica / Q000453:epidemiology; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D015996:Survival Rate