[Interferon status of patients with uveal melanoma].
Interferon status of patients with uveal melanoma was studied at different stages of the disease. All parameters of alpha- and gamma-interferon production were decreased both in vitro and in vivo. The T2-3 stages were associated with an imbalance of the production of two interferon types: augmenting deficiency of alpha-interferon with a tendency to a higher production of gamma-interferon by leukocytes in vitro. Generalization of T3-4N0Mhep melanoma was characterized by hyperproduction of gamma-interferon and total serum interferon. These data indicate a pathogenetic significance of disorders in interferon production in uveal melanoma and may be used for the disease prognosis.
Likhvantseva
V G
VG
Slepova
O S
OS
Brovkina
A F
AF
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood*; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D014604:Uveal Neoplasms / Q000097:blood* / Q000473:pathology
D014408:Biomarkers, Tumor; D016898:Interferon-alpha; D007371:Interferon-gamma