title: Organ-specific immune responses associated with infectious disease.
abstract: The immune response to infection can vary markedly in different organs of the same animal. In some organs, the infection can resolve with subsequent immunity to re-infection, whereas in other organs, pathogens can persist. Here, Christian Engwerda and Paul Kaye highlight the importance of defining organ-specific immune mechanisms for developing strategies that deal effectively with infectious diseases and their associated pathologies.
authors.affiliation: Dept of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK WC1E 7HT. c.engwerda@lshtm.ac.uk
authors.forename: C R
authors.initials: CR
authors.lastname: Engwerda
authors.forename: P M
authors.initials: PM
authors.lastname: Kaye
mesh_terms: D000818:Animals; D018450:Disease Progression; D007249:Inflammation; D007694:Killer Cells, Natural / Q000502:physiology; D007893:Leishmania donovani / Q000472:pathogenicity; D018314:Leishmania infantum / Q000472:pathogenicity; D007898:Leishmaniasis, Visceral / Q000276:immunology* / Q000469:parasitology / Q000503:physiopathology; D051379:Mice; D009928:Organ Specificity / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000469:parasitology; D013601:T-Lymphocytes / Q000502:physiology; D014781:Viscera / Q000276:immunology* / Q000469:parasitology* / Q000473:pathology