Cholesterol and triglyceride levels in the serum of muricidal male Wistar rats: indices of mitochondrial benzodiazepine receptors?
Cholesterol and triglyceride levels were studied in the serum of aggressive muricidal and non-muricidal male Wistar rats. The muricidal behavior was either spontaneous or induced by a long-term isolation or by adrenalectomy. Cholesterol levels were slightly higher in the whole population of muricidal rats; this was mainly observed in spontaneously and in adrenalectomized muricidal rats, as compared to non-muricidal rats of the same series. As regards triglyceride levels, they were significantly higher in the whole population of muricidal rats, mainly in isolation- and adrenalectomy-induced muricidal rats; the ratio of triglycerides to body weight was higher in the serum of muricidal rats of all series. The possible significance of these results is discussed in light of the data of the literature and related to the functional role of either mitochondrial benzodiazepine receptors or serotonin.
Miachon
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S
INSERM U 480 Faculté de Medecine Grange-Blanche et Laboratoire de Biochimie, Hopital Edouard Herriot, Lyon, France. secretariat@sommeil.univ-lyon1.fr
Jouvenet
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M
Vallon
J J
JJ
D000315:Adrenalectomy; D000374:Aggression / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D002784:Cholesterol / Q000097:blood*; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D012934:Social Isolation; D014280:Triglycerides / Q000097:blood*
D011963:Receptors, GABA-A; D014280:Triglycerides; D012701:Serotonin; D002784:Cholesterol