title: Expression of the mucosal vascular addressin, MAdCAM-1, in inflammatory liver disease.
abstract: OBJECTIVE
  The integrin alpha4beta7 and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) are involved in normal recirculation of lymphocytes between the blood and the tissues of the gastrointestinal tract. In this study we have examined the expression of MAdCAM-1 in human liver.
  
  
  METHODS
  MAdCAM-1 expression was determined in archival human liver tissues by immunohistochemistry.
  
  
  RESULTS
  While MAdCAM-1 was not detected in normal fetal or adult human liver, expression was observed in association with portal tract inflammation in a variety of liver diseases. Detailed analysis of liver biopsies from patients with hepatitis C showed a positive correlation between the portal/periportal component of the histological activity index (HAI) grade and the presence or absence of MAdCAM-1 expression.
  
  
  CONCLUSIONS
  MAdCAM-1 expression may be important in the recruitment of lymphocytes to the liver during inflammation.
authors.affiliation: Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.
authors.forename: K J
authors.initials: KJ
authors.lastname: Hillan
authors.forename: K E
authors.initials: KE
authors.lastname: Hagler
authors.forename: R N
authors.initials: RN
authors.lastname: MacSween
authors.forename: A M
authors.initials: AM
authors.lastname: Ryan
authors.forename: M E
authors.initials: ME
authors.lastname: Renz
authors.forename: H H
authors.initials: HH
authors.lastname: Chiu
authors.forename: R K
authors.initials: RK
authors.lastname: Ferrier
authors.forename: G L
authors.initials: GL
authors.lastname: Bird
authors.forename: A P
authors.initials: AP
authors.lastname: Dhillon
authors.forename: L D
authors.initials: LD
authors.lastname: Ferrell
authors.forename: S
authors.initials: S
authors.lastname: Fong
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D018952:Antigens, CD34 / Q000378:metabolism; D001666:Binding Sites, Antibody; D015815:Cell Adhesion Molecules; D004797:Enzyme-Linked Immunosorbent Assay; D005333:Fetus / Q000378:metabolism; D006505:Hepatitis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D009088:Mucoproteins / Q000378:metabolism*; D011817:Rabbits; D017464:Receptors, Complement 3d / Q000378:metabolism; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34; D015815:Cell Adhesion Molecules; D007136:Immunoglobulins; C504265:MADCAM1 protein, human; D009088:Mucoproteins; D017464:Receptors, Complement 3d; D016201:Receptors, Lymphocyte Homing