title: Fractionated stereotactic radiation therapy and single high-dose radiosurgery for acoustic neuroma: early results of a prospective clinical study.
abstract: OBJECTIVE
  To prospectively assess the local control and toxicity rate in acoustic neuroma patients treated with linear accelerator-based radiosurgery and fractionated stereotactic radiation therapy.
  
  
  METHODS
  We evaluated 37 consecutive patients treated with stereotactic radiation therapy for acoustic neuroma. All patients had progressive tumors, progressive symptoms, or both. Mean tumor diameter was 2.3 cm (range 0.8-3.3) on magnetic resonance (MR) scan. Dentate patients were given a dose of 5x4 Gy or 5x5 Gy and edentate patients were given a dose of 1x10 Gy or 1x12.50 Gy prescribed to the 80% isodose. All patients were treated with a single isocenter.
  
  
  RESULTS
  With a mean follow-up period of 25 months (range 12-61), the actuarial local control rate at 5 years was 91% (only 1 patient failed). The actuarial rate of hearing preservation at 5 years was 66% in previously-hearing patients. The actuarial rate of freedom from trigeminal nerve toxicity was 97% at 5 years. No patient developed facial nerve toxicity or other complications.
  
  
  CONCLUSIONS
  In this unselected series, fractionated stereotactic radiation therapy and linear accelerator-based radiosurgery give excellent local control in acoustic neuroma. It combines a high rate of preservation of hearing with a very low rate of other toxicity, although follow-up is relatively short.
authors.affiliation: Department of Radiation Oncology, University Hospital VU-Ziekenhuis, Amsterdam, The Netherlands. owm.meijer@azvu.nl
authors.forename: O W
authors.initials: OW
authors.lastname: Meijer
authors.forename: J G
authors.initials: JG
authors.lastname: Wolbers
authors.forename: J C
authors.initials: JC
authors.lastname: Baayen
authors.forename: B J
authors.initials: BJ
authors.lastname: Slotman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000150:complications / Q000532:radiotherapy* / Q000601:surgery*; D010315:Particle Accelerators; D011446:Prospective Studies; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D000160:Vestibulocochlear Nerve Diseases / Q000150:complications / Q000532:radiotherapy* / Q000601:surgery*