Successful pregnancy by intracytoplasmic sperm injection after radiotherapy-induced azoospermia.
A 27-year-old male, who underwent excision and radiotherapy for a pineal gland germinoma four years previously, subsequently developed panhypopituitarism and, thus, complete azoospermia. Gonadotrophin replacement therapy resulted in the production of a small number of motile spermatozoa which were used for Intracytoplasmic Sperm Injection (ICSI) into oocytes obtained from his wife. After successful fertilization and embryo transfer, a singleton intrauterine pregnancy was achieved which resulted in the normal delivery of a morphologically normal male live infant at term.
Ramsewak
S
S
Assisted Reproduction Unit, Medical Associates Hospital, St Joseph, Trinidad.
Naraynsingh
A
A
Kuruvilla
A
A
Duffy
S
S
D000328:Adult; D005260:Female; D018237:Germinoma / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007018:Hypopituitarism / Q000150:complications; D008297:Male; D009845:Oligospermia / Q000209:etiology*; D010871:Pinealoma / Q000532:radiotherapy / Q000601:surgery; D011247:Pregnancy; D011256:Pregnancy Outcome; D011832:Radiation Injuries / Q000150:complications; D020554:Sperm Injections, Intracytoplasmic; D014300:Trinidad and Tobago