title: MTSA-10, the product of the Rv3874 gene of Mycobacterium tuberculosis, elicits tuberculosis-specific, delayed-type hypersensitivity in guinea pigs.
abstract: In a search for new skin test reagents specific for tuberculosis, we found that the antigen encoded by gene Rv3874 of Mycobacterium tuberculosis elicited delayed-type hypersensitivity in M. tuberculosis-infected guinea pigs but not in control animals immunized with Mycobacterium bovis bacillus Calmette-Guérin (BCG) or Mycobacterium avium. The antigen, which was named MTSA-10 (for M. tuberculosis-specific antigen 10), is a prime candidate for a component of a new tuberculin that will allow discrimination by a skin test of latent M. tuberculosis infection from vaccination with BCG or from sensitization with environmental, nontuberculous mycobacteria.
authors.affiliation: Public Health Research Institute, New York, New York 10016, USA.
authors.forename: R
authors.initials: R
authors.lastname: Colangeli
authors.forename: J S
authors.initials: JS
authors.lastname: Spencer
authors.forename: P
authors.initials: P
authors.lastname: Bifani
authors.forename: A
authors.initials: A
authors.lastname: Williams
authors.forename: K
authors.initials: K
authors.lastname: Lyashchenko
authors.forename: M A
authors.initials: MA
authors.lastname: Keen
authors.forename: P J
authors.initials: PJ
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Belisle
authors.forename: M L
authors.initials: ML
authors.lastname: Gennaro
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001500:BCG Vaccine / Q000276:immunology; D005260:Female; D005798:Genes, Bacterial; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D014374:Tuberculin Test
chemical_list: D000942:Antigens, Bacterial; D001500:BCG Vaccine