title: Polyglutamine repeat length influences human androgen receptor/c-Jun mediated transcription.
abstract: The androgen receptor and c-Jun are known to interact to modulate each others transcriptional activities. The androgen receptor contains a polymorphic polyglutamine repeat and expansion of this repeat to beyond approximately 40 causes spinobulbar muscular atrophy (SBMA; also known as Kennedy's disease), a genetic form of motor neurone disease. Here we show that the size of this polyglutamine tract influences both c-Jun regulation of androgen receptor-mediated transcription and androgen receptor regulation of c-Jun activity. c-Jun is a key mediator of neuronal survival and death by apoptosis. Inappropriate interactions between c-Jun and androgen receptors containing pathological length glutamine repeats may therefore be part of the pathogenic process in SBMA.
authors.affiliation: Department of Neuroscience, The Institute of Psychiatry, London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Grierson
authors.forename: R C
authors.initials: RC
authors.lastname: Mootoosamy
authors.forename: C C
authors.initials: CC
authors.lastname: Miller
mesh_terms: D002478:Cells, Cultured; D005809:Genes, Regulator / Q000235:genetics*; D006801:Humans; D020966:Muscular Disorders, Atrophic / Q000503:physiopathology; D010455:Peptides / Q000235:genetics* / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics* / Q000378:metabolism; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics*
chemical_list: D010455:Peptides; D016755:Proto-Oncogene Proteins c-jun; D011944:Receptors, Androgen; C097188:polyglutamine