title: Reactive spindle cell nodules of the breast after core biopsy or fine-needle aspiration.
abstract: Reactive spindle cell nodules (RSCNs) arising postoperatively or after fine-needle aspiration (FNA) have been reported previously in the genitourinary tract and thyroid. We describe 18 cases of similar lesions in breast, associated with a history of core needle biopsy or FNA. The majority of the RSCNs (15 cases) were associated with papillary lesions or complex sclerosing lesions. The RSCNs were nonencapsulated and relatively nodular, measuring 1.5 to 9 mm. They were composed of spindle cells with mild to moderate nuclear pleomorphism and a low mitotic count. A network of small blood vessels, macrophages, and lymphocytes was present in all cases. Immunohistochemically, the spindle cells expressed smooth and specific muscle actins, supporting a myofibroblastic origin. The association of RSCNs with needle trauma to fibrosclerotic lesions, such as complex sclerosing lesions and papillary lesions that regularly have myofibroblasts, suggests an exuberant reparative cause. Recognition of this reactive process will avoid overdiagnosis of mammary spindle cell malignant neoplasm.
authors.affiliation: Division of Anatomical Pathology, Vanderbilt University Medical Center, Nashville, TN 37232-2561, USA.
authors.forename: H
authors.initials: H
authors.lastname: Gobbi
authors.forename: G
authors.initials: G
authors.lastname: Tse
authors.forename: D L
authors.initials: DL
authors.lastname: Page
authors.forename: S J
authors.initials: SJ
authors.lastname: Olson
authors.forename: R A
authors.initials: RA
authors.lastname: Jensen
authors.forename: J F
authors.initials: JF
authors.lastname: Simpson
mesh_terms: D000199:Actins / Q000032:analysis; D000328:Adult; D000368:Aged; D001706:Biopsy / Q000009:adverse effects*; D001707:Biopsy, Needle / Q000009:adverse effects*; D001940:Breast / Q000098:blood supply / Q000473:pathology*; D001943:Breast Neoplasms; D002467:Cell Nucleus / Q000473:pathology; D005189:False Positive Reactions; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000473:pathology; D008264:Macrophages / Q000473:pathology; D008875:Middle Aged; D008938:Mitosis
chemical_list: D000199:Actins