title: [Heterogeneity of diabetes mellitus].
abstract: OBJECTIVE
  To define a criterium for differentiation of different types of diabetes mellitus (DM).
  
  
  METHODS
  The condition of immunity, antibodies to the pancreatic island cells, proliferative activity of peripheral blood lymphocytes in response to human immunoglobulin were studied in 152 patients with DM.
  
  
  RESULTS
  Sensitization of lymphocytes to insulin is associated with DM type I. Latent sensitization of lymphocytes to insulin detectable in inhibition of functional activity of prostaglandin-synthesizing cells is encountered in classic course of DM type II, while detectable in inhibition of functional activity of the cells carrying receptors to histamine is observed in patients with symptoms of either DM type I or DM type II. Lack of either apparent or latent lymphocyte sensitization to insulin in chronic hyperglycemia is associated with secondary DM.
  
  
  CONCLUSIONS
  How lymphocytes are sensitized to insulin is important for differential diagnosis not only of DM type but also of DM forms within the same type. Groups of the DM patients were different not only by immunological indices but also by clinical course, treatment and prognosis.
authors.forename: N S
authors.initials: NS
authors.lastname: Asfandiiarova
authors.forename: N G
authors.initials: NG
authors.lastname: Kolcheva
authors.forename: I V
authors.initials: IV
authors.lastname: Shatrova
mesh_terms: D015415:Biomarkers / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis / Q000276:immunology; D007136:Immunoglobulins / Q000276:immunology; D007328:Insulin / Q000276:immunology*; D007515:Islets of Langerhans / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D011968:Receptors, Histamine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015415:Biomarkers; D007136:Immunoglobulins; D007328:Insulin; D011968:Receptors, Histamine