Structure and chromosome mapping of the human SIX4 and murine Six4 genes.
Six4, a member of the homeobox gene subfamily (Six), is expressed in a developmentally regulated fashion, and supposed to be involved in embryogenesis. We cloned the human SIX4 and murine Six4 genomic DNAs and determined their structures. The structure, including the 5' upstream region of both genes, was well conserved suggesting the conserved function and regulation of these genes. Human SIX4 was mapped to chromosome 14q23.
Ozaki
H
H
Department of Biology, Jichi Medical School, Tochigi, Japan.
Yamada
K
K
Kobayashi
M
M
Asakawa
S
S
Minoshima
S
S
Shimizu
N
N
Kajitani
M
M
Kawakami
K
K
D000595:Amino Acid Sequence; D000818:Animals; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics*; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D005091:Exons / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns / Q000235:genetics; D008214:Lymphocytes; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020161:Physical Chromosome Mapping; D011401:Promoter Regions, Genetic / Q000235:genetics; D020218:Response Elements / Q000235:genetics; D016415:Sequence Alignment; D015534:Trans-Activators
D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; C490851:SIX4 protein, human; C098490:Six4 protein, mouse; D015534:Trans-Activators