title: Effects of prone position on alveolar recruitment and oxygenation in acute lung injury.
abstract: OBJECTIVE
  To investigate the effects of prone position (PP) on alveolar recruitment and oxygenation in acute respiratory failure.
  
  
  METHODS
  Prospective physiologic study.
  
  
  METHODS
  Medical ICU two in a university hospital.
  
  
  METHODS
  Twelve adult patients intubated and mechanically ventilated with medical primary acute lung injury/adult respiratory distress syndrome (ALI/ARDS) in whom PP was indicated.
  
  
  RESULTS
  We constructed the static inflation volume-pressure curves (V-P) of the respiratory system in the 12 patients and differentiated between lung and chest wall in ten of them. We determined the difference between end-expiratory lung volume on positive end-expiratory pressure (PEEP) and relaxation volume of the respiratory system on zero PEEP (delta FRC). The recruited alveolar volume was computed as the delta FRC times the ratio of static elastance of the respiratory system to the lung. These measurements together with arterial blood gases determination were made in supine position (SP1), after 1 h of PP and after 1 h of supine repositioning (SP2) at the same level of PEEP. The PaO2/FIO2 ratio improved from SP1 to PP (136 +/- 17 vs 204 +/- 24 mm Hg; p < 0.01). An PP-induced alveolar recruitment was found in five patients. The change in oxygenation correlated to the recruited volume. The static elastance of the chest wall decreased from 4.62 +/- 0.99 cmH2O/l in SP1 to 6.26 +/- 0.54 cmH2O/l in PP (p < 0.05) without any correlation to the change in oxygenation.
  
  
  CONCLUSIONS
  Alveolar recruitment may be a mechanism of oxygenation improvement in some patients with acute hypoxemic respiratory failure. No correlation was found between change in oxygenation and chest wall elastic properties.
authors.affiliation: Service de Réanimation Médicale et Assistance Respiratoire, Hôpital de la Croix-Rousse, Lyon, France. c-guerin@cismsun.univ-lyon1.fr
authors.forename: C
authors.initials: C
authors.lastname: Guerin
authors.forename: M
authors.initials: M
authors.lastname: Badet
authors.forename: S
authors.initials: S
authors.lastname: Rosselli
authors.forename: L
authors.initials: L
authors.lastname: Heyer
authors.forename: J M
authors.initials: JM
authors.lastname: Sab
authors.forename: B
authors.initials: B
authors.lastname: Langevin
authors.forename: F
authors.initials: F
authors.lastname: Philit
authors.forename: G
authors.initials: G
authors.lastname: Fournier
authors.forename: D
authors.initials: D
authors.lastname: Robert
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D005260:Female; D005602:France; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D016684:Prone Position / Q000502:physiology; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D015656:Respiratory Mechanics / Q000502:physiology*; D016896:Treatment Outcome