Cycling lipids.
When synaptic vesicles fuse with the presynaptic plasma membrane, their membrane constituents are recycled by internalisation into clathrin-coated vesicles. To form new synaptic vesicles, the clathrin coat must be shed and recent studies reveal that a lipid phosphatase, synaptojanin, plays a central role in this process.
Stenmark
H
H
Department of Biochemistry, The Norwegian Radium Hospital, Oslo, N-0310, Norway. stenmark@ulrik.uio.no.
D002135:Calcium-Binding Proteins; D002966:Clathrin / Q000378:metabolism; D005089:Exocytosis; D008561:Membrane Fusion; D008562:Membrane Glycoproteins / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D050857:Synaptotagmins
D002135:Calcium-Binding Proteins; D002966:Clathrin; D008562:Membrane Glycoproteins; D008563:Membrane Lipids; D009419:Nerve Tissue Proteins; D050857:Synaptotagmins