title: Application of Combinatorial Procedures in the Search for Serine-Protease-Like Activity with Focus on the Acyl Transfer Step.
abstract: Recursive deconvolution of a 729-membered peptide library has identified three active sequences, in which both Ser and His are present in one of the two tripeptidic chains generated on a steroidal scaffold (see structural formula), for the cleavage of an activated p-nitrophenyl ester. This combinatorial approach aims at searching for serine-protease-like activity.
authors.affiliation: Laboratory for Organic Synthesis Department of Organic Chemistry, University of Gent Krijgslaan 281, 9000 Gent (Belgium).
authors.lastname: De Muynck H
authors.initials: A
authors.lastname: Madder
authors.initials: N
authors.lastname: Farcy
authors.lastname: De Clercq PJ
authors.initials: MN
authors.lastname: Pérez-Payán
authors.initials: LM
authors.lastname: Öhberg
authors.initials: AP
authors.lastname: Davis