title: [L-glutamic acid--a modulator of the physiological status of myeloid series blood cells].
abstract: The effects of L-glutamic acid on the differentiation of HL-60 and K-562 cell lines and on the expression level of mRNAs encoding IL-1 beta, IL-6, and TNF alpha were studied. It was shown that TNF alpha actively induces the differentiation of these cell lines, whereas L-glutamic acid enhances its effect. Our results indicated that L-glutamic acid modulates the physiological state of the myeloid cell line in blood, in particular, by affecting both the reception and expression of cytokines functionally important for these cells.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Astapova
authors.forename: V M
authors.initials: VM
authors.lastname: Lipkin
authors.forename: M V
authors.initials: MV
authors.lastname: Arkhipova
authors.forename: S G
authors.initials: SG
authors.lastname: Andreeva
authors.forename: S M
authors.initials: SM
authors.lastname: Dranitsyna
authors.forename: M I
authors.initials: MI
authors.lastname: Merkulova
authors.forename: R I
authors.initials: RI
authors.lastname: Nurieva
authors.forename: E V
authors.initials: EV
authors.lastname: Navolotskaia
authors.forename: I A
authors.initials: IA
authors.lastname: Kostanian
mesh_terms: D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D018698:Glutamic Acid / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D020014:K562 Cells; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D018698:Glutamic Acid