Genome-wide screen for atopy susceptibility alleles in the Hutterites.
A genome-wide screen for loci influencing positive skin prick tests (SPT) to airborne allergens was conducted in the Hutterites, a founder population of European ancestry. Positive SPT to 14 standardized allergens was measured in 370 subjects in our primary sample and 324 subjects in a replication sample. Evidence for linkage to positive SPT was assessed using the transmission disequilibrium test (TDT) with 337 autosomal markers (average spacing 9.13 cM, SD = 7.8 cM). Three loci showed the strongest overall evidence of linkage to atopy, with at least one allele-specific and a locus-specific p< 1 x 10(-4). This study provides evidence for at least three atopy-susceptibility loci in the Hutterites on chromosomes 1, 6 and 16.
Ober
C
C
Department of Human Genetics, The University of Chicago, IL 60636, USA.
Tsalenko
A
A
Willadsen
S
S
Newman
D
D
Daniel
R
R
Wu
X
X
Andal
J
J
Hoki
D
D
Schneider
D
D
True
K
K
Schou
C
C
Parry
R
R
Cox
N
N
D000328:Adult; D000483:Alleles; D002874:Chromosome Mapping; D005006:Ethnicity; D005060:Europe; D005260:Female; D018703:Founder Effect; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D044465:White People