Regulation of JNK by Src during Drosophila development.
In Drosophila, the Jun amino-terminal kinase (JNK) homolog Basket (Bsk) is required for epidermal closure. Mutants for Src42A, a Drosophila c-src protooncogene homolog, are described. Src42A functions in epidermal closure during both embryogenesis and metamorphosis. The severity of the epidermal closure defect in the Src42A mutant depended on the amount of Bsk activity, and the amount of Bsk activity depended on the amount of Src42A. Thus, activation of the Bsk pathway is required downstream of Src42A in epidermal closure. This work confirms mammalian studies that demonstrated a physiological link between Src and JNK.
Tateno
M
M
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
Nishida
Y
Y
Adachi-Yamada
T
T
D000199:Actins / Q000378:metabolism; D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D029721:Drosophila Proteins; D004789:Enzyme Activation; D004817:Epidermis / Q000196:embryology; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D048031:JNK Mitogen-Activated Protein Kinases; D008675:Metamorphosis, Biological; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010641:Phenotype; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D017354:Point Mutation; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D000199:Actins; D029721:Drosophila Proteins; D019476:Insect Proteins; D011518:Proto-Oncogene Proteins; C064196:dpp protein, Drosophila; D019000:Phosphotyrosine; C113193:Tec29 protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases; C075699:Src64B protein, Drosophila; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases; C110854:puc protein, Drosophila; D010749:Phosphoprotein Phosphatases