The changes of serum soluble intercellular adhesion molecule-1 after systemic steroid treatment in vitiligo.
Cell surface adhesion molecules are thought to play an important role in establishing intercellular contacts that are necessary for immunological reactions. Intercellular adhesion molecule-1 (ICAM-1, CD54) is a crucial adhesion molecule in mediating cell to cell adhesion during inflammatory responses, including non-MHC-restricted cytotoxicity. In this study, the sICAM-1 levels of ten healthy control subjects and seven generalized active vitiligo patients were measured by ELISA. The sICAM-1 levels were also correlated with the clinical courses in 33 patients with active vitiligo, who received systemic steroid treatment for 3 months. The average serum level of sICAM-1 was significantly higher in patients with active vitiligo than in the healthy control subjects. The sICAM-1 levels significantly decreased after systemic steroid treatment in the clinically improved group. These results suggest that immune activation is involved in active vitiligo and that changes of sICAM-1 levels can be a marker in the course of vitiliginous lesions.
Hwang
J H
JH
Department of Dermatology, College of Medicine, Seoul National University, South Korea.
Ahn
J S
JS
Kim
S D
SD
Lim
J G
JG
Kim
Y G
YG
Kim
K H
KH
Park
K C
KC
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D013256:Steroids / Q000627:therapeutic use*; D014820:Vitiligo / Q000097:blood* / Q000188:drug therapy
D013256:Steroids; D018799:Intercellular Adhesion Molecule-1