title: New multifunctional percutaneous transluminal coronary angioplasty catheter device capable of balloon inflation, local drug delivery and coronary perfusion.
abstract: A new percutaneous transluminal coronary angioplasty catheter with multiple functions of balloon inflation, local drug delivery and coronary perfusion has been devised. The device consists of an inflatable lumen, a drug delivery lumen, and a perfusion (or guide wire) lumen. A drug can be infused from the port located distal to the inflated balloon during continuous blood perfusion via the perfusion lumen. Fluorescence-labeled heparin and peroxidase administered using the device permeated into denuded vessel tissues during ongoing perfusion and remained there for over 24 hr. This prototype device indicates the potential therapeutic implications of the concepts of the device.
authors.affiliation: Division of Cardiology, Hospital, National Cardiovascular Center, Osaka.
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: S
authors.initials: S
authors.lastname: Yasuda
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: K
authors.initials: K
authors.lastname: Kanda
authors.forename: N
authors.initials: N
authors.lastname: Tsutsui
authors.forename: H
authors.initials: H
authors.lastname: Nonogi
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D000818:Animals; D002404:Catheterization; D004285:Dogs; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D010477:Perfusion / Q000295:instrumentation*