title: Clinico-laboratory characteristics of patients with dermatomyositis accompanied by rapidly progressive interstitial lung disease.
abstract: The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n = 7) and those with chronic interstitial lung disease (C-ILD, n = 9), and also between deceased (seven RP-ILD and three C-ILD) and living patients (six C-ILD). The extent of muscle weakness of the extremities and frequency of autoantibody positivity were significantly lower in DM patients with RP-ILD than in DM patients with C-ILD. Furthermore, significantly lower serum creatine kinase/lactate dehydrogenase levels (0.26+/-0.27) were found in the 10 patients who died than in the six living patients (1.21+/-1.09). A higher CD4+/CD8+ T-lymphocyte ratio in the peripheral blood (3.51+/-2.65) was detected in the four DM patients with RP-ILD who died than in the six living DM patients with C-ILD (1.22+/-0.49).
authors.affiliation: Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Kaise
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Kazuta
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D016516:CD4-CD8 Ratio; D003402:Creatine Kinase / Q000378:metabolism; D003882:Dermatomyositis / Q000097:blood / Q000150:complications* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000209:etiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000473:pathology; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology; D013902:Radiography, Thoracic; D016176:T-Lymphocyte Subsets / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase