Significant association between the tau gene A0/A0 genotype and Parkinson's disease.
A significant association between the tau gene A0/A0 genotype and progressive supranuclear palsy has been reported recently. To determine if the presence of a tau polymorphism could constitute a risk factor for the development of sporadic and familial Parkinson's disease, a dinucleotide repeat marker at intron 11 was genotyped in 152 patients with PD, 52 patients with Alzheimer's disease, and 150 healthy controls. We detected a significant difference in A0 allelic frequency in the Parkinson's disease group (79.27%) compared with the control group (71%) and the Alzheimer's disease group (73.07%). Individuals homozygous for the A0 allele were also detected significantly more frequently in the Parkinson's disease group (63.8%) compared with the control group (52.66%) and the Alzheimer's disease group (48.07%). These results suggest a possible involvement of the tau gene in the pathogenesis of some cases of Parkinson's disease.
Pastor
P
P
Neurology Service, Hospital Clínic Universitari, Institut d'Investigacions Biomèdique August Pi i Sunyer, Barcelona, Spain.
Ezquerra
M
M
Muñoz
E
E
Martí
M J
MJ
Blesa
R
R
Tolosa
E
E
Oliva
R
R
D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics; D018900:Dinucleotide Repeats / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000523:psychology; D012016:Reference Values; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins