[Effects some drugs of re-epithelialization in the early postoperative period after photorefraction keratectomy].
Terms of re-epithelialization, severity of the painful syndrome, intensity of corneal "crepe" (opacity) are assessed in myopic patients treated by maxitrol, eubetal, colbiocin ointments and maxitrol eyedrops in the early postoperative period after photorefraction keratectomy. The crepe intensity was assessed routinely according to a clinical score: 0) transparent cornea, 1) trace crepe; 2) moderate crepe; and 3) intensive crepe. Biomicroscopy on day 4 after photorefraction keratectomy showed complete epithelialization in 91.7% patients after colbiocin ointment, in 91.% after maxitrol eyedrops, 87% after eubetal ointment, and 82.6% after maxitrol ointment. The least corneal opacity (0 and 0-1) was observed after eubetal ointment and maxitrol eyedrops. The mean score for pain was virtually the same in all groups; in the colbiocin ointment group more patients complained of pain for more than 24 h in comparison with other groups.
Kurenkov
V V
VV
Smirennaia
E V
EV
Polunin
G S
GS
Makarov
I A
IA
D001623:Betamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D003091:Colistin / Q000008:administration & dosage / Q000627:therapeutic use*; D003318:Corneal Opacity / Q000517:prevention & control; D004338:Drug Combinations; D019573:Epithelium, Corneal / Q000502:physiology*; D005477:Fluprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D054018:Lasers, Excimer; D009216:Myopia / Q000601:surgery; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D009883:Ophthalmic Solutions; D018903:Photorefractive Keratectomy; D011112:Polymyxin B / Q000008:administration & dosage / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D011184:Postoperative Period; D012382:Rolitetracycline; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D004338:Drug Combinations; C085363:Eubetal; D009824:Ointments; D009883:Ophthalmic Solutions; C113023:chloramphenicol, colistimethate sodium, rolitetracycline drug combination; D002701:Chloramphenicol; C049064:Maxitrol; D001623:Betamethasone; D005477:Fluprednisolone; D013752:Tetracycline; D012382:Rolitetracycline; D009355:Neomycin; D011112:Polymyxin B; D003091:Colistin