[Effect of the brain 5-HT2 receptor blockade on gastric mucosa damage caused by social stress in males of two mouse strains].
Mice-losers in social conflicts had an increased number of haemorrhages and erosions in gastric mucosa as compared with the control and winners-mice. Administration of ciproheptadine and/or ketanserin enhanced the neurogenic gastric damage both in the winners and in control mice. The CBA strain mice were more sensitive to the damaging effects of the drugs than the C57-strain winners. The experience of social confrontations seems to change the gastric mucosa condition and to modify the mucosa response to the brain serotonine receptor blockade, depending on the social confrontations outcome and the animals' genotype.
Koriakina
L A
LA
Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, Novosibirsk, Russia.
D000818:Animals; D003220:Conflict, Psychological; D003533:Cyproheptadine / Q000494:pharmacology; D005753:Gastric Mucosa / Q000473:pathology*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000473:pathology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013045:Species Specificity; D013315:Stress, Psychological / Q000150:complications / Q000473:pathology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D007650:Ketanserin