title: Transmission of symptomatic parvovirus B19 infection by fibrin sealant used during surgery.
abstract: Human parvovirus B19 infection has been shown to be transmissible by blood and blood products and to result in transient aplastic crisis in patients with rapid red cell turnover. We report three cases of iatrogenic parvovirus B19 infection resulting from the use of the same batch of fibrin sealant under operation. Fibrin sealant, which is a typical haemostatic agent produced from blood, has been used during surgery. Human parvovirus is resistant to existing virus-inactivating techniques, suggesting that infection may occur from blood products contaminated with it. Use of recombinant products for these proteins may thus be necessary.
authors.affiliation: Department of Clinical Haematology, Osaka City University Medical School, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: K I
authors.initials: KI
authors.lastname: Honda
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: T
authors.initials: T
authors.lastname: Takubo
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000328:Adult; D004866:Equipment Contamination; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects*; D006801:Humans; D007431:Intraoperative Complications / Q000821:virology*; D008297:Male; D010322:Parvoviridae Infections / Q000635:transmission*; D016732:Parvovirus B19, Human; D014014:Tissue Adhesives / Q000009:adverse effects*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives