5-(beta-Cyclodextrinylamino)-5-Deoxy-alpha-D-Riboses as Models for Nuclease, Ligase, Phosphatase, and Phosphorylase.
beta-Cyclodextrin derivatives crowned with ribose rings (such as 1) catalyzed the hydrolysis, esterification, and phosphorylation of catechol-derived phosphate esters. The vicinal cis-diols on the ribose groups appear to play a major role in the catalytic activity of these enzyme models by the formation of hydrogen bonds which activate the phosphorus atom to nucleophilic attack.
Han
MJ
Department of Molecular Science and Technology Ajou University, Suwon 442-749 (Korea).
Yoo
KS
Chang
JY
Ha
TK