[Molecular mechanisms of cell-cell and cell-matrix interactions in the pathophysiology of rheumatoid arthritis].
The original structure of the synovial membrane is completely destroyed in the rheumatoid synovium and is characterized by mononuclear cell infiltration, synoviocyte proliferation, neo-vascularization, and deposition of extracellular matrix proteins. Adhesion molecules play an important role in the development of these pathologic changes. In this review we discuss the role of the adhesion receptors of the selectin, integrin and immunoglobulin families and of the CD44 molecule in the cell-cell and cell-matrix interaction in the pathogenesis of the inflammatory changes in rheumatoid arthritis.
Rinaldi
N
N
Abt. Infektiologie und Klinische Immunologie, III. Medizinische Klinik, Ulm.
Schwarz-Eywill
M
M
D001172:Arthritis, Rheumatoid / Q000503:physiopathology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D005109:Extracellular Matrix / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000502:physiology; D013583:Synovial Membrane / Q000503:physiopathology*
D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D016023:Integrins