[Idiopathic hypophysitis in elderly patients. Report of 2 cases and review of literature].
BACKGROUND
Hypophysis inflammatory tumors are a non frequent cause for hypopituitarism. The motive of outpatient visit is headache. It is more frequent in pregnancy and immediate post-labor women. The pathology shows a lymphocytic inflammatory infiltrated or granulomas with giant cells (these can be accompanied with an infectious or autoimmune systemic disease associated).


METHODS
We present two elderly female patients, without infectious or autoimmune pathology associated, with suggestive abnormalities of hypophysial adenoma by MRI. Both presented a suspecting clinical manifestation of intracranial expansive lesion (progressive intensive headaches, with partial compromise of the III left pair in the second one), noticing by laboratory a subclinical hormonal dysfunction. Surgery of tumoral exeresis was underwent in both patients, showing a granulomatous hypophysitis in one and a lymphocytic hypophysitis in the other.


CONCLUSIONS
Hypophysis inflammatory tumors must be considered as a preoperative differential diagnosis of every hypophysial tumor without important hormonal dysfunction associated, mainly in women and what is more in pregnancy or lying-in women, taking into account that surgery of tumoral resection can worsen a subclinic hypophysial dysfunction.
Echevarría
G
G
Servicio de Neurología, Hospital Privado de Comunidad, Mar del Plata, Buenos Aires, Argentina.
Gonorazky
S
S
Gaspari
M
M
Sundblad
A
A
D000236:Adenoma / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D007018:Hypopituitarism / Q000175:diagnosis / Q000209:etiology; D007249:Inflammation; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery