title: The spectrum of ocular inflammation caused by euphorbia plant sap.
abstract: OBJECTIVE
  To report the spectrum of clinical findings in patients with ocular inflammation caused by plant sap from Euphorbia species.
  
  
  METHODS
  Clinical case series.
  
  
  METHODS
  Ophthalmology emergency referrals in the United Kingdom.
  
  
  METHODS
  We examined 7 patients, all of whom gave a history of recent ocular exposure to the sap of Euphorbia species.
  
  
  METHODS
  All patients were treated with antibiotic drops or ointment (chloramphenicol). Cycloplegic and steroid drops were also used for some patients. Patients were observed until all signs and symptoms had resolved.
  
  
  METHODS
  Symptoms, visual acuity, and clinical signs of inflammation. All patients provided a specimen of the plant for formal identification.
  
  
  RESULTS
  Initial symptoms were generally burning or stinging pain with blurred vision. In most cases, visual acuity was reduced between 1 and 2 Snellen lines. In 1 patient with age-related maculopathy, acuity dropped from 20/80 to hand motions before recovering. Clinical findings varied from a mild epithelial keratoconjunctivitis to a severe keratitis with stromal edema, epithelial sloughing, and anterior uveitis. All signs and symptoms had resolved by 1 to 2 weeks.
  
  
  CONCLUSIONS
  These cases illustrate the range of severity of Euphorbia sap keratouveitis. The condition seems to be self-limiting when managed supportively. People who work with Euphorbia plant species should wear eye protection. Clinicians managing keratopathy caused by Euphorbia species should be aware of the danger of sight-threatening infection and uveitis, particularly during the first few days.
authors.affiliation: Department of Ophthalmology, Leicester Royal Infirmary, United Kingdom.
authors.forename: T
authors.initials: T
authors.lastname: Eke
authors.forename: S
authors.initials: S
authors.lastname: Al-Husainy
authors.forename: M K
authors.initials: MK
authors.lastname: Raynor
mesh_terms: D000328:Adult; D000368:Aged; D002701:Chloramphenicol / Q000627:therapeutic use; D003519:Cyclopentolate / Q000627:therapeutic use; D019665:Euphorbiaceae / Q000506:poisoning*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007637:Keratoconjunctivitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009824:Ointments; D009883:Ophthalmic Solutions; D010936:Plant Extracts / Q000506:poisoning*; D010939:Plant Poisoning / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007507:Therapeutic Irrigation; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D005938:Glucocorticoids; D009824:Ointments; D009883:Ophthalmic Solutions; D010936:Plant Extracts; D002701:Chloramphenicol; D003519:Cyclopentolate