title: Clonal hematopoiesis in acquired aplastic anemia revealed by rearrangement of the immunoglobulin heavy chain gene-JH region.
abstract: We report on a female patient with acquired aplastic anemia whose bone marrow cells showed DNA rearrangement of the immunoglobulin-JH region that disappeared after 1 month with recovery of hematopoiesis through treatment with granulocyte colony-stimulating factor (G-CSF) and immunosuppressive drugs. The patient is now 2 years and 6 months from onset, and her hematopoiesis is almost within normal limits without medication. This finding provides new data supporting clonal hematopoiesis in acquired aplastic anemia but does not imply that the disease is resistant to immunosuppressive therapy.
authors.affiliation: Department of Pediatrics, Yamanashi Medical University, Japan. ksugita@res.yamanashi-med.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Sugita
authors.forename: N
authors.initials: N
authors.lastname: Miyamoto
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: K
authors.initials: K
authors.lastname: Goi
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Karakida
authors.forename: A
authors.initials: A
authors.lastname: Ogiwara
authors.forename: S
authors.initials: S
authors.lastname: Nakazawa
mesh_terms: D000741:Anemia, Aplastic / Q000188:drug therapy / Q000473:pathology*; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000473:pathology*; D002648:Child; D002999:Clone Cells / Q000473:pathology*; D005260:Female; D000069585:Filgrastim; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006410:Hematopoiesis; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D011994:Recombinant Proteins; D012074:Remission Induction; D013601:T-Lymphocytes
chemical_list: D000961:Antilymphocyte Serum; D007143:Immunoglobulin Heavy Chains; D007166:Immunosuppressive Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim; D008775:Methylprednisolone