DNA defects target the centrosome.
When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to segregate chromosomes. These defects may result from the workings of a surveillance mechanism that acts to cull irreparable nuclei.
Su
T T
TT
Vidwans
S J
SJ
D000818:Animals; D018385:Centrosome / Q000502:physiology*; D004249:DNA Damage; D004330:Drosophila / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D008957:Models, Genetic