Quaking*shiverer double-mutant mice survive for at least 100 days with no CNS myelin.
Mice expressing mutations that produce CNS hypomyelination often die prematurely: the more severe the hypomyelination, the shorter the life span. However, we have previously described jimpy-msd mice that survive twice as long as usual; although they acquire significantly increased amounts of myelin, they still succumb long before their unaffected littermates. This result contradicts any postulated causal relationship between extent of CNS hypomyelination and premature death of the animal. Here we have addressed this question in another way, by using an animal model that does not involve a proteolipid protein (Plp) gene mutation. We demonstrate that quaking*shiverer double-mutant mice can survive for at least 100 days without any CNS myelin whatsoever. Therefore, at least for a mouse, absence of CNS myelin is not lethal per se.
Wolf
M K
MK
Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Susan.Gagliardi@umassmed.edu
Nunnari
J N
JN
Billings-Gagliardi
S
S
D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D002493:Central Nervous System Diseases / Q000235:genetics / Q000401:mortality / Q000473:pathology; D005838:Genotype; D008136:Longevity / Q000235:genetics; D051379:Mice; D008818:Mice, Neurologic Mutants; D008821:Mice, Quaking / Q000235:genetics*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology* / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000648:ultrastructure; D010641:Phenotype; D016019:Survival Analysis