[The role of deformability of endothelial cells in the arterial response to shear tension].
Treatment of the femoral artery luminal surface with glutaraldehyde dimere or dithiosuccinimidyl propionate reduced or eliminated flow-induced dilation, the responses to acetylcholine and the ATP being preserved. The findings suggest that the endothelial cells perceive changes in shear stress and that the cell stiffness is a factor subject to the influence of the magnitude of flow-induced arterial dilation.
Mel'kumiants
A M
AM
Cardiological Research-Industrial Complex, Moscow, Russia.
Balashov
S A
SA
D000818:Animals; D002415:Cats; D002417:Cattle; D048429:Cell Size / Q000187:drug effects; D002478:Cells, Cultured; D019281:Dimerization; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005263:Femoral Artery / Q000187:drug effects / Q000502:physiology*; D005976:Glutaral / Q000494:pharmacology; D006801:Humans; D012039:Regional Blood Flow; D013314:Stress, Mechanical
D005976:Glutaral