Interrelationships of transcriptional machinery with nuclear architecture.
There is increasing evidence for functional linkages between nuclear architecture and the regulation of gene expression. The nuclear matrix provides a paradigm for involvement of nuclear morphology in assembly of the biochemical machinery for physiological control of transcription. Mechanisms are being experimentally defined that direct regulatory factors to subnuclear sites that support gene expression. Consequently, we are gaining insight into the rules that govern transcriptional control within the three-dimensional context of nuclear organization.
Stein
G S
GS
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester 01655, USA.
van Wijnen
A J
AJ
Stein
J L
JL
Lian
J B
JB
D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry / Q000235:genetics* / Q000648:ultrastructure; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D005786:Gene Expression Regulation; D006801:Humans; D015530:Nuclear Matrix / Q000737:chemistry / Q000235:genetics / Q000648:ultrastructure; D014158:Transcription, Genetic
D002843:Chromatin