title: Discriminatory power of MRI for differentiation of adrenal non-adenomas vs adenomas evaluated by means of ROC analysis: can biopsy be obviated?
abstract: The purpose of our study was to evaluate the discriminatory power of MRI in high-field magnet (1.5 T) for differentiation of adrenal non-adenomas vs adenomas assessing the following parameters separately and in combination: mean diameter of adrenal mass; previously described and new ratios as well as index calculated from signal intensity (SI) on SE T2-weighted images, chemical shift imaging (CSI), and Gd-DTPA-enhanced dynamic studies. One hundred eight adrenal masses (36 non-hyperfunctioning adenomas, 27 pheochromocytomas, 23 aldosterone-secreting adenomas, 20 malignant masses and 2 cortisol-secreting adenomas) in 95 patients were evaluated with SE sequences, CSI and Gd-DTPA dynamic studies. Indices and ratios of SI for all examined MRI methods were calculated and examined retrospectively for significance of differences between the groups with calculation of sensitivity and specificity. Receiver operating characteristics (ROC) analysis of calculated parameters in combination was performed. The multifactorial analysis of all four parameters, including size of the tumor, T2(liver) index, CSI ratio reflecting lipid content in the tumor and Wo(max/last) ratio reflecting maximal washout of contrast agent from the tumor had 100 % sensitivity and 100 % specificity in characterization of adrenal non-adenoma. The best performance of combination of mean tumor diameter with single MRI SI parameter was achieved in combination with T2(liver) index for all adrenal masses (area under ROC 0.987) and CSI ratio for non-hyperfunctioning adrenal masses (area under ROC 0.991). Magnetic resonance imaging enables sensitive and specific diagnosis of adrenal non-adenoma.
authors.affiliation: Department of Imaging, Warsaw Medical School, ul. Kondratowicza 8, PL-03-285 Warsaw, Poland.
authors.forename: R Z
authors.initials: RZ
authors.lastname: Slapa
authors.forename: W
authors.initials: W
authors.lastname: Jakubowski
authors.forename: A
authors.initials: A
authors.lastname: Januszewicz
authors.forename: A A
authors.initials: AA
authors.lastname: Kasperlik-Zaluska
authors.forename: E
authors.initials: E
authors.lastname: Dabrowska
authors.forename: J
authors.initials: J
authors.lastname: Fijuth
authors.forename: T
authors.initials: T
authors.lastname: Feltynowski
authors.forename: R
authors.initials: R
authors.lastname: Tarnawski
authors.forename: L
authors.initials: L
authors.lastname: Królicki
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity