title: Aspiration of nasal secretions into the lungs in patients with acute sinonasal infections.
abstract: OBJECTIVE
  To compare the amounts of nasal secretions aspirated into the lower airway by patients with acute sinonasal infection with that aspirated by healthy adults during sleep.
  
  
  METHODS
  Sixteen patients who had received a diagnosis of acute sinonasal infections by accurate history, anterior rhinoscopic examination, and radiological assessment and 13 healthy volunteers, aged 14 to 45 years.
  
  
  METHODS
  A 10-mCi dose of technetium 99m-labeled macroaggregated albumin (Tc-99m MAA) with a concentration of 1 mCi/mL was prepared at midnight, just before sleep. Each subject was administered two puffs of this spray. At 8 AM the next morning transmission and emission views of the thorax were taken with a gamma camera.
  
  
  RESULTS
  No significant difference between the two groups was observed in the amounts of nasal secretions aspirated into the lungs.
  
  
  CONCLUSIONS
  The amount of nasal secretions aspirated does not increase during acute sinonasal infection. However, by irritating the mucosa of the lower respiratory tracts, bacteria, toxins, and inflammatory products existing in purulent secretions may play a major role in the pathophysiology of asthma and sinusitis.
authors.affiliation: Department of ENT, Faculty of Medicine, Marmara University, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ozagar
authors.forename: F
authors.initials: F
authors.lastname: Dede
authors.forename: T
authors.initials: T
authors.lastname: Turoğlu
authors.forename: C
authors.initials: C
authors.lastname: Uneri
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D009668:Nose Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D010254:Paranasal Sinus Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D011015:Pneumonia, Aspiration / Q000000981:diagnostic imaging / Q000209:etiology*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012141:Respiratory Tract Infections / Q000150:complications* / Q000000981:diagnostic imaging; D012890:Sleep; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin