[Effect of cocaine on the contractile response to noradrenaline in the epididymal and prostatic regions of the vas deferens].
In the prostatic half of the rat vas deferens, the response to noradrenaline under the cocaine effect revealed a phasic and a tonic components, whereas in the epididymal portion of the vas deferens there only occurred the tonic component. Cocaine increased the maximal tonic contractile response to noradrenaline in the epididymal portion and the maximal phasic response--in the prostatic one. Mechanisms of direct postsynaptic action of cocaine are discussed.
Berdysheva
L V
LV
N. K. Koltsov Institute of Developmental Biology of the Russian Acad Sci., Moscow, Russia.
Kichikulova
T P
TP
Manukhin
B N
BN
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D004822:Epididymis; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology*; D011467:Prostate; D051381:Rats; D017208:Rats, Wistar; D014649:Vas Deferens / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology
D003042:Cocaine; D009638:Norepinephrine