title: Oceanapiside, an antifungal bis-alpha,omega-amino alcohol glycoside from the marine sponge Oceanapia phillipensis.
abstract: The structure of oceanapiside, an antifungal alpha, omega-bis-aminohydroxylipid glycoside from the temperate marine sponge Oceanapia sp., was elucidated by a combination of 2D NMR, chemical degradation/correlation, and MALDI MS-MS spectrometry. Oceanapiside exhibits antifungal activity against Candida glabrata at 10 micrograms/mL (MIC).
authors.affiliation: Department of Chemistry, University of California, Davis 95616, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Nicholas
authors.forename: T W
authors.initials: TW
authors.lastname: Hong
authors.forename: T F
authors.initials: TF
authors.lastname: Molinski
authors.forename: M L
authors.initials: ML
authors.lastname: Lerch
authors.forename: M T
authors.initials: MT
authors.lastname: Cancilla
authors.forename: C B
authors.initials: CB
authors.lastname: Lebrilla
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification*; D006017:Glycolipids / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000935:Antifungal Agents; D006017:Glycolipids; C404387:oceanapiside