title: 2-Phenylquinoline-Carbohydrate Hybrids: Molecular Design, Chemical Synthesis, and Evaluation of a New Family of Light-Activatable DNA-Cleaving Agents.
abstract: Artificial intercalator-carbohydrate hybrids such as that shown in the scheme cleave DNA at the site of guanine on irradiation with UV light with a long wavelength. The hybrids also exhibit strong cytotoxicity when irradiated. The hybrid system is very important for DNA cleavage, and the cytotoxic activity correlates with the DNA-cleaving capacity
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi Kohoku-ku, Yokohama 223-8522 (Japan).
authors.initials: K
authors.lastname: Toshima
authors.initials: R
authors.lastname: Takano
authors.initials: Y
authors.lastname: Maeda
authors.initials: M
authors.lastname: Suzuki
authors.initials: A
authors.lastname: Asai
authors.initials: S
authors.lastname: Matsumura