[Fibric acid derivatives].
Fibric acid derivatives show remarkable reduction of triglyceride rich lipoproteins and increment of high density lipoproteins. Recently, it is revealed that fibrate activate the nuclear peroxisome proliferator-activated receptor (PPAR) alpha and thereby alter the transcription of genes controlling lipoprotein metabolism. Additionally, fibrates inhibit the activation of aortic smooth muscle cells and lower the plasma fibrinogen concentration, which are also anti-atherogenic factors. Many prevention studies revealed that fibrates prevent ischemic heart disease of hyperlipidemic patients, suggesting not only high level of low-density-lipoprotein cholesterol but hypertriglyceridemia, low high-density-lipoprotein cholesterol level and high level of fibrinogen may be the definite risks of atherosclerosis.
Kinoshita
M
M
Teikyo University School of Medicine.
D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002994:Clofibrate / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000517:prevention & control; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D000960:Hypolipidemic Agents; D002994:Clofibrate