title: The EcoRV genetic polymorphism of human monoamine oxidase type A is not associated with Parkinson's disease and does not modify the effect of smoking on Parkinson's disease.
abstract: We previously observed an association with Parkinson's (PD), and modification of the effect of smoking on PD, by a polymorphism of the monoamine oxidase B (MAO-B) gene. The A form of monoamine oxidase (MAO-A) shares with MAO-B many characteristics that could be relevant to PD, especially proneuroxicant bioactivation and dopamine metabolism. MAO-A is also inhibited by tobacco smoke, which bears an apparent protective effect on PD. We investigated the possibility that MAO-A genetic variants may also be involved in predisposition to PD and in modification of the effect of smoking. Three-hundred and seventy-one subjects--145 idiopathic PD cases and 226 age/gender-matched controls--were genotyped for the EcoRV polymorphism of MAO-A gene which has been related to increased enzyme activity. MAO-A EcoRV polymorphism was neither significantly associated with PD nor did it modify the inverse relationship with smoking. These results suggest that the EcoRV polymorphism of MAO-A is not an important biomarker of PD risk.
authors.affiliation: Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle 98105-6099, USA. cstpla@u.washington.edu
authors.forename: P
authors.initials: P
authors.lastname: Costa-Mallen
authors.forename: H
authors.initials: H
authors.lastname: Checkoway
authors.forename: M
authors.initials: M
authors.lastname: Fishel
authors.forename: A W
authors.initials: AW
authors.lastname: Cohen
authors.forename: T
authors.initials: T
authors.lastname: Smith-Weller
authors.forename: G M
authors.initials: GM
authors.lastname: Franklin
authors.forename: P D
authors.initials: PD
authors.lastname: Swanson
authors.forename: L G
authors.initials: LG
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001711:Biotransformation; D015252:Deoxyribonucleases, Type II Site-Specific; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000235:genetics*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000201:enzymology / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012907:Smoking / Q000235:genetics*
chemical_list: D008995:Monoamine Oxidase; D015252:Deoxyribonucleases, Type II Site-Specific; C027440:GATATC-specific type II deoxyribonucleases; D004298:Dopamine