A family of chromatin remodeling factors related to Williams syndrome transcription factor.
Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.
Bochar
D A
DA
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Savard
J
J
Wang
W
W
Lafleur
D W
DW
Moore
P
P
Côté
J
J
Shiekhattar
R
R
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D000595:Amino Acid Sequence; D000818:Animals; D002843:Chromatin / Q000378:metabolism* / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000378:metabolism; D003850:Deoxyribonuclease I / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D005656:Fungal Proteins / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D009687:Nuclear Proteins; D009707:Nucleosomes / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000502:physiology; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism / Q000502:physiology; D018980:Williams Syndrome / Q000235:genetics*; D000092468:Bromodomain Containing Proteins
D000251:Adenosine Triphosphatases; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004265:DNA Helicases; D004268:DNA-Binding Proteins; D003850:Deoxyribonuclease I; D029721:Drosophila Proteins; D005656:Fungal Proteins; D046911:Macromolecular Substances; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D009707:Nucleosomes; D016601:RNA-Binding Proteins; D017412:Ribonucleoprotein, U1 Small Nuclear; D014157:Transcription Factors; C120419:Acf protein, Drosophila; C492319:BAZ1A protein, human; D000092468:Bromodomain Containing Proteins; C086468:ISWI protein; C499336:SMARCA1 protein, human; C084011:SMARCA2 protein, human; C089969:snf protein, Drosophila; C084108:SMARCA4 protein, human