title: A fatal case of craniofacial necrotizing fasciitis.
abstract: A case of fatal craniofacial necrotizing fasciitis is described in a 72-year-old diabetic woman and management is discussed. Progressive infection of the eyelids occurred with involvement of the right side of the face. Computed tomography revealed soft tissue swelling. Antibiotic treatment was started and debridement performed; histopathology showed acute inflammation and thrombosis of the epidermis and dermis. Despite treatment, scepticemia occurred, resulting in death less than 48 h after presentation. At this time extensive necrosis had developed in the superficial fascia with undermining and gangrene of surrounding tissues. Streptococcus and Staphylococcus were the pathogens involved. Poor prognosis in similar patients has been associated with extensive infection, involvement of the lower face and neck, delayed treatment, advanced age, diabetes and vascular disease.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Beerens
authors.forename: L J
authors.initials: LJ
authors.lastname: Bauwens
authors.forename: C R
authors.initials: CR
authors.lastname: Leemans
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D048909:Diabetes Complications; D005141:Eyelid Diseases / Q000601:surgery; D005145:Face; D019115:Fasciitis, Necrotizing / Q000382:microbiology / Q000473:pathology / Q000601:surgery*; D017809:Fatal Outcome; D005260:Female; D005734:Gangrene; D006801:Humans; D009336:Necrosis; D010400:Penicillin G / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D011379:Prognosis; D018805:Sepsis / Q000382:microbiology; D012886:Skull; D013203:Staphylococcal Infections; D013290:Streptococcal Infections; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D002981:Clindamycin; D010400:Penicillin G