Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans.
A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans. Increasing TC was associated with increased AD risk in the group with no epsilon4 alleles, whereas TC was not associated with increased AD risk in the group with one or more epsilon4 alleles. Further study of the relationship between cholesterol and APOE genotype is needed to confirm this association, but the results suggest that cholesterol may be a potentially modifiable environmental risk factor for AD.
Evans
R M
RM
Department of Neurology, Indiana University School of Medicine, Indianapolis 46202-5111, USA.
Emsley
C L
CL
Gao
S
S
Sahota
A
A
Hall
K S
KS
Farlow
M R
MR
Hendrie
H
H
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000208:ethnology* / Q000209:etiology* / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People; D002784:Cholesterol / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D012307:Risk Factors; D001741:Black or African American
D001057:Apolipoproteins E; D002784:Cholesterol