title: Calf blood flow during prolonged tilt in idiopathic dilated cardiomyopathy and after cardiac transplantation.
abstract: In severe congestive heart failure (CHF), abnormal reflex control of calf blood flow during brief head-up tilt that appears to normalize after transplantation (HTX) may be present during prolonged observation also. Therefore, we studied the effect of prolonged (30 min) 50 degrees head-up tilt on calf skeletal muscle blood flow measured by the local (133)Xe washout method in CHF and after HTX and in patients with the presence vs. absence of native right atrium (+PNA and -PNA, respectively). During brief head-up tilt, skeletal muscle blood flow increased 13 +/- 42% in 9 severe CHF patients in contrast to a -28 +/- 22% decrease (P < 0.01) in 11 control subjects, -24 +/- 30% decrease in 15 moderate CHF patients (P < 0.05), -25 +/- 14% decrease in 12 patients with recent HTX (P < 0.01), and -21 +/- 24% decrease in 8 patients with distant HTX (P = 0.06). However, during sustained tilt, blood flow declined to similar levels of that in the other groups in severe CHF. HTX -PNA vs. +PNA showed blunted skeletal muscle vasomotor control (P < 0.05) and a higher systolic blood pressure (139 +/- 14 vs. 125 +/- 15 mmHg, P < 0.05) and heart rate (92 +/- 10 vs. 83 +/- 8 beats/min, P < 0.05). Thus paradox vasodilatation of calf skeletal muscle in severe CHF is present only during brief but not prolonged tilt. This may be one explanation of the rare presence of orthostatic intolerance in CHF and implies only a minor possible role for the abnormality in edema pathogenesis. Removal of all right atrium in HTX has an important hemodynamic impact that may possibly affect later clinical outcome.
authors.affiliation: The Heart Center, The Rigshospital, DK-2100 Copenhagen, Denmark. Galatius@dadlnet.dk
authors.forename: S
authors.initials: S
authors.lastname: Galatius
authors.forename: H
authors.initials: H
authors.lastname: Wroblewski
authors.forename: V B
authors.initials: VB
authors.lastname: Sørensen
authors.forename: P
authors.initials: P
authors.lastname: Bie
authors.forename: H
authors.initials: H
authors.lastname: Arendrup
authors.forename: J
authors.initials: J
authors.lastname: Kastrup
mesh_terms: D000328:Adult; D016280:Atrial Function, Right; D001794:Blood Pressure; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology*; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D018475:Head-Down Tilt; D006339:Heart Rate; D016027:Heart Transplantation / Q000379:methods; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply; D011184:Postoperative Period; D011187:Posture / Q000502:physiology; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply; D013997:Time Factors
chemical_list: D019332:Endothelin-1