title: [Isolation of acyclovir-resistant strains of herpes simplex virus from clinical material].
abstract: A total of 115 strains of herpes simplex virus were isolated from clinical material collected in patients with genital herpes. The majority (93%) of isolated strains were sensitive to acyclovir: ID50 varied from 0.15 to 0.80 microgram/ml acyclovir. Eleven (7%) strains from 4 patients were resistant to acyclovir: ID50 was 30-125 times higher in comparison with the reference HSV-1 strain L2.
authors.forename: N D
authors.initials: ND
authors.lastname: L'vov
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: N A
authors.initials: NA
authors.lastname: Leont'eva
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
mesh_terms: D000212:Acyclovir / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002522:Chlorocebus aethiops; D004352:Drug Resistance, Microbial; D005260:Female; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D008297:Male; D018139:Simplexvirus / Q000187:drug effects* / Q000302:isolation & purification; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir