title: Anti-plasmodial sesquiterpenoids from the African Reneilmia cincinnata.
abstract: A new isodaucane sesquiterpenoid, 6,7,10-trihydoxyisodaucane, was isolated from the fruits of Reneilmia cincinnata, together with the known sesquiterpenoids oplodiol, oplopanone, 5E,10(14)-germacradien-1 beta, 4 beta-diol, 1(10)E,5E-germacradien-4 alpha-ol and eudesman-1,4,7-triol. A large amount of 5-hydroxy-3,7,4'-trimethoxyflavone was also isolated. Their structures were established by NMR techniques using 1D and 2D experiments. Three of the known sesquirernenoids exhibited noteworthy anti-plasmodial activity against Plasmodium falciparum strains.
authors.affiliation: Chemistry Department, Faculty of Science, University of Dschang, Cameroon.
authors.forename: M H
authors.initials: MH
authors.lastname: Tchuendem
authors.forename: J A
authors.initials: JA
authors.lastname: Mbah
authors.forename: A
authors.initials: A
authors.lastname: Tsopmo
authors.forename: J F
authors.initials: JF
authors.lastname: Ayafor
authors.forename: O
authors.initials: O
authors.lastname: Sterner
authors.forename: C C
authors.initials: CC
authors.lastname: Okunjic
authors.forename: M M
authors.initials: MM
authors.lastname: Iwu
authors.forename: B M
authors.initials: BM
authors.lastname: Schuster
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019862:Zingiberales / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D012717:Sesquiterpenes