title: [A case of unresectable gallbladder cancer responding to combination therapy with hyperthermia and local chemotherapy].
abstract: A 78-year-old woman was admitted to our hospital for the control of gallbladder cancer. A peritoneal metastasis, diagnosed as unresectable cancer, was detected during surgery in a previous hospital, and a biliary stent was introduced and gastrojejunostomy was performed. In our hospital she was treated weekly with local chemotherapy (PFL; cisplatin 2.5-5 mg/body ia, fluorouracil 300 mg/body ia, and calcium folinate 30 mg/body ia, via the common hepatic arterial port) at the time of hyperthermia. Hyperthermia was performed with a Thermox 500 (HEH-500 C) at the power of 500 watts for 45-60 minutes. To enhance the hyperthermia effect, mitomycin C 2-4 mg/body ia via the common hepatic arterial port and 500 ml of 7.5% glucose infusion were given. As a result of the combination therapy, the volume of the whole tumor was reduced to 60.9% on computed tomography, and diagnosed as PR. The serum level of CA19-9 decreased from 3,000 U/ml to 300 U/ml. The patient continued to receive the therapy for 1 year, and is now well. Therefore, we conclude that combination therapy with hyperthermia and local chemotherapy seems beneficial in managing unresectable advanced gallbladder cancer, especially for the elderly.
authors.affiliation: Dept. of Surgery, Toride Kyodo General Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Kawasaki
authors.forename: E
authors.initials: E
authors.lastname: Yabata
authors.forename: T
authors.initials: T
authors.lastname: Gen
authors.forename: M
authors.initials: M
authors.lastname: Jibiki
authors.forename: A
authors.initials: A
authors.lastname: Kudoh
authors.forename: N
authors.initials: N
authors.lastname: Noguchi
authors.forename: T
authors.initials: T
authors.lastname: Kataoka
authors.forename: K
authors.initials: K
authors.lastname: Teramoto
authors.forename: T
authors.initials: T
authors.lastname: Iwai
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005706:Gallbladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D002955:Leucovorin / Q000008:administration & dosage; D016685:Mitomycin / Q000008:administration & dosage; D010534:Peritoneal Neoplasms / Q000556:secondary
chemical_list: D016685:Mitomycin; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil