Induction of GM-CSF production of macrophages by advanced glycation end products of the Maillard reaction.
We previously reported that AGEs can induce macrophage growth. In this paper, we examined whether advanced glycation end products (AGE) of protein induced GM-CSF production of macrophages. AGE of bovine serum albumin markedly stimulated not only the expression of GM-CSF mRNA, but also GM-CSF secretion in macrophage supernatant. Thus GM-CSF is suggested to be an endogenous signal for macrophage growth induction by AGEs.
Sasaki
T
T
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Horiuchi
S
S
Yamazaki
M
M
Yui
S
S
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000187:drug effects; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000494:pharmacology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000235:genetics*; D007700:Kinetics; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000502:physiology*; D015416:Maillard Reaction; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012333:RNA, Messenger / Q000235:genetics; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D017127:Glycation End Products, Advanced; D012333:RNA, Messenger; C081628:advanced glycation end products-bovine serum albumin; D012710:Serum Albumin, Bovine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor