RNA-binding proteins: TRAPping RNA bases.
In Bacillus subtilis, tryptophan biosynthesis is regulated by a mechanism called attenuation. The new crystal structure of the 'trp RNA binding attenuation protein', TRAP, in complex with RNA has provided new structural insights into how proteins can bind RNA to regulate transcription and translation.
Muto
Y
Y
MRC Laboratory of Molecular Biology, Cambridge, UK.
Oubridge
C
C
Nagai
K
K
D001412:Bacillus subtilis / Q000378:metabolism*; D001426:Bacterial Proteins; D001665:Binding Sites; D018360:Crystallography, X-Ray; D029721:Drosophila Proteins; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009876:Operon; D039102:Poly(A)-Binding Proteins; D011485:Protein Binding; D011487:Protein Conformation; D012329:RNA, Bacterial / Q000737:chemistry / Q000378:metabolism*; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D012097:Repressor Proteins / Q000737:chemistry / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry / Q000502:physiology*; D014364:Tryptophan / Q000096:biosynthesis*
D001426:Bacterial Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C079092:MtrB protein, Bacteria; D039102:Poly(A)-Binding Proteins; D012329:RNA, Bacterial; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012097:Repressor Proteins; C067777:Sxl protein, Drosophila; D014157:Transcription Factors; D014364:Tryptophan