Current status of acrolein as a lipid peroxidation product.
There is increasing evidence that aldehydes generated endogenously during lipid peroxidation contribute to the pathophysiologic effects associated with oxidative stress in cells and tissues. A number of reactive lipid aldehydes, such as 4-hydroxy-2-alkenals and malondialdehyde, have been implicated as causative agents in cytotoxic processes initiated by the exposure of biologic systems to oxidizing agents. Recently, acrolein (CH2 = CH-CHO), a ubiquitous pollutant in the environment, was identified as a product of lipid peroxidation reactions. The basis for this finding is an experimental approach that provides a measure of acrolein bound to lysine residues of protein. The identification of acrolein as an endogenous lipid-derived product suggests an examination of the possible role of this aldehyde as a mediator of oxidative damage in a variety of human diseases.
Uchida
K
K
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Science, Japan.
D000171:Acrolein / Q000737:chemistry / Q000378:metabolism*; D000393:Air Pollutants / Q000737:chemistry / Q000378:metabolism*; D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D006037:Glyoxal / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008315:Malondialdehyde / Q000737:chemistry / Q000378:metabolism; D018384:Oxidative Stress
D000393:Air Pollutants; D000447:Aldehydes; D003432:Cross-Linking Reagents; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D008315:Malondialdehyde; D006037:Glyoxal; D000171:Acrolein; C027576:4-hydroxy-2-nonenal; D008239:Lysine