title: Possible intraspinal metastasis of a canine spinal cord nephroblastoma.
abstract: A 2-year-old Basset Hound was admitted to the University of Florida Veterinary Medical Teaching Hospital with progressive spastic paraparesis. At necropsy, intradural extramedullary tumors produced areas of spinal cord swelling and softening in spinal cord segments T11-T12 and L4-L6. Histologic examination of the masses revealed sheets of polygonal blastemal cells, epithelial cells forming tubules and rosettes, and embryonal glomeruloid-like structures in the thoracic mass. Cells in the lumbar mass were less differentiated, forming rare tubules and no glomeruloid-like structures. The occurrence of two tumors in the spinal cord along with the less differentiated appearance of the lumbar tumor raises the possibility that the lumbar mass arose as a result of intraspinal metastasis. To our knowledge, this is the first report of multifocal or metastatic canine spinal nephroblastoma. In addition, the vimentin and cytokeratin immunohistochemical staining characteristics of these spinal cord nephroblastomas are described.
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville 32611, USA. TerrellS@mail.vetmed.ufl.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Terrell
authors.forename: S R
authors.initials: SR
authors.lastname: Platt
authors.forename: C L
authors.initials: CL
authors.lastname: Chrisman
authors.forename: B L
authors.initials: BL
authors.lastname: Homer
authors.forename: A
authors.initials: A
authors.lastname: de Lahunta
authors.forename: B A
authors.initials: BA
authors.lastname: Summers
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001259:Ataxia / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology / Q000662:veterinary*; D008159:Lumbar Vertebrae; D009362:Neoplasm Metastasis; D020335:Paraparesis / Q000662:veterinary; D013120:Spinal Cord Neoplasms / Q000556:secondary / Q000662:veterinary*; D013904:Thoracic Vertebrae; D009396:Wilms Tumor / Q000473:pathology / Q000556:secondary / Q000662:veterinary*
chemical_list: D000911:Antibodies, Monoclonal