[Renal ischemia reperfusion syndrome].
Ischemia reperfusion injury is an uncommon kind of inflammation. Oxygen deprivation is followed by cellular dysfunction, reversible or not and mainly tubular. Ischemia initiates and amplifies the fundamental events of reperfusion injury, that are going to occur after oxygen reintroduction. Reperfusion is characterized by the production of oxygen reactive species, endothelial activation, endothelial release of chemoattractants, chemokines and cytokines, expression of adhesion molecules, that are going to mediate the recruitment and activation of circulating leucocytes, later responsible for the main lesions of reperfusion injury. Studies in kidney transplantation have brought evidence that the fibrotic healing of reperfusion injury have long term and significant consequences on kidney function.
Hourmant
M
M
Service de néphrologie et d'immunologie clinique. Hôtel Dieu, CHU, Nantes.
D015687:Cell Hypoxia; D005609:Free Radicals; D006439:Hemodynamics; D006801:Humans; D007511:Ischemia; D007668:Kidney / Q000098:blood supply*; D007962:Leukocytes / Q000502:physiology; D015427:Reperfusion Injury; D013577:Syndrome
D005609:Free Radicals