title: [The safety of ofloxacin].
abstract: The data on a comparative study of ofloxacin arthrotoxicity in pediatric and adult patients are presented. The tolerability of ofloxacin used in various doses and treatment terms (acute and cumulative effects) was investigated in children. The impact of the patient pubertal age, sex, ofloxacin concentrations (Cmax above 4 micrograms/ml) and arthrological diseases (in adult patients) on the risk of the quinolone arthropathy was evaluated. Good tolerability of the various ofloxacin dosing regimens in both the adult and pediatric patients was shown.
authors.affiliation: Chair of Clinical Pharmacology, Unit of Medical Genetics, Russian State Medical University, Moscow.
authors.forename: S S
authors.initials: SS
authors.lastname: Postnikov
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Semykin
authors.forename: O V
authors.initials: OV
authors.lastname: Efremenkova
authors.forename: A V
authors.initials: AV
authors.lastname: Sokolov
authors.forename: N I
authors.initials: NI
authors.lastname: Kapranov
authors.forename: D V
authors.initials: DV
authors.lastname: Litvinov
mesh_terms: D000293:Adolescent; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007596:Joints / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D012449:Safety; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D015242:Ofloxacin