Anticandidal activity of SPA-S-843, a new polyenic drug.
The activity of a new, soluble and stable polyene (SPA-S-843) against Candida albicans was assessed by contact and culture tests and by inhibition of germ-tube formation. The drug demonstrated a higher contact activity and lower MICs than amphotericin B. This antimicrobial activity was more evident under acid pH and low ionic strength. In addition, the ability of SPA-S-843 to inhibit Candida sp. conversion from yeast to mycelial form was evident at low drug concentrations (0.25-0.62 mg/L).
Strippoli
V
V
Institute of Microbiology, Faculties of Medicine and Surgery and Pharmacy, University of Rome 'La Sapienza', viale Regina Margherita, 255, 00198 Rome, Italy.
D'Auria
F D
FD
Simonetti
G
G
Bruzzese
T
T
Simonetti
N
N
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D003470:Culture Media; D004553:Electric Conductivity; D008826:Microbial Sensitivity Tests; D011090:Polyenes / Q000494:pharmacology*; D011188:Potassium / Q000737:chemistry
D000935:Antifungal Agents; D003470:Culture Media; D011090:Polyenes; C115650:SPA S 843; D000666:Amphotericin B; D011188:Potassium