title: The management of Behçet's syndrome.
abstract: Behçet's syndrome (BS), originally described as a triad of oral aphthae, genital ulcerations and uveitis, is a systemic vasculitis that is prevalent in the Middle east, Far East and in the Mediterranean basin. It is characterized by a heightened state of inflammation although the main drive that initiates and sustains this is not yet elucidated. Suppression of this inflammatory state constitutes the major goal of treatment and therapy is tailored according to the specific manifestations observed. We now have considerable more insight on drug management of BS compared to 20 years ago. Particularly, within the recent past we have learned to use more rationally the agents that were already available to us. This is especially true for azathioprine, cyclosporin A, thalidomide and colchicine. Promising data are also being collected with alpha-interferon. With these agents, significant progress has been achieved in the management of uveitis and mucocutaneous symptoms but treatment issues related to thrombotic problems, major vessel involvement and neurological disease have not yet been resolved.
authors.affiliation: Department of Internal Medicine, Cerrahpaia Medical School, Istanbul, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Fresko
authors.forename: S
authors.initials: S
authors.lastname: Yurdakul
authors.forename: V
authors.initials: V
authors.lastname: Hamuryudan
authors.forename: Y
authors.initials: Y
authors.lastname: Ozyazgan
authors.forename: C
authors.initials: C
authors.lastname: Mat
authors.forename: M M
authors.initials: MM
authors.lastname: Tanverdi
authors.forename: H
authors.initials: H
authors.lastname: Yazici
mesh_terms: D001528:Behcet Syndrome / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male