The hypoglycemic activity of Zygophyllum gaetulum extracts in alloxan-induced hyperglycemic rats.
The aqueous infusion of the aerial parts of Zygophyllum gaetulum Emb. and Maire was tested orally (1 g/kg body weight) for hypoglycemic activity in alloxan-induced diabetic rats. The infusion was partitioned between water and butanol to yield a butanol soluble fraction (B), and an aqueous fraction (W) which on reduction in volume gave a precipitate (WP) and supernatant (WS). Fractions (B) and (WP) caused significant reduction in blood glucose concentration, while the ingestion of (WS) produced no significant reduction in blood glucose level.
Jaouhari
J T
JT
Department of Biology, High School of Education, Marrakesh, Morocco.
Lazrek
H B
HB
Jana
M
M
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts