title: Association between platelet glycoprotein Ibalpha genotype and ischemic cerebrovascular disease.
abstract: OBJECTIVE
  Platelets play pivotal roles in the development of ischemic cerebrovascular disease (CVD). The platelet glycoprotein (GP) Ib/IX/V complex is a receptor for von Willebrand factor, which plays a major role in the initial phase of platelet activation under high shear stress conditions. This study was designed to investigate the association between a genetic variation of this receptor and the prevalence of CVD.
  
  
  METHODS
  Two hundred patients with ischemic CVD, as confirmed by brain CT and/or MRI, and 317 age- and sex-matched control subjects without clinical evidence of CVD or cardiovascular disease were analyzed for their genotype frequencies of the (145)Thr/Met dimorphism of the alpha-chain of GPIb (GPIbalpha).
  
  
  RESULTS
  Genotypes with (145)Met (T/M and M/M) were more frequently found in the CVD patients (26.5%) than in control subjects (14.2%, P=0.0005). The genotype effect was more obvious in those <60 years of age or without acquired cardiovascular risk factors. The odds ratio for nonsmoking women <60 years of age was 10. 6 (95% confidence intervals, 2.2 to 51.7). Although the number of patients studied was small (n=24), transient ischemic attack showed the highest odds ratio (4.3, P=0.0004), followed by lacunar infarction (OR=2.2, P=0.0024) and atherothrombotic infarction (OR=1. 5, P=0.3143). Logistic regression analysis revealed that the presence of Met-allele was independently associated with CVD.
  
  
  CONCLUSIONS
  Our study suggests that the platelet GPIbalpha genotype is a genetic risk factor for ischemic CVD.
authors.affiliation: Departments of Laboratory Medicine, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Sonoda
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: D
authors.initials: D
authors.lastname: Ito
authors.forename: N
authors.initials: N
authors.lastname: Tanahashi
authors.forename: A
authors.initials: A
authors.lastname: Ohta
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: E
authors.initials: E
authors.lastname: Takeshita
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuuchi
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000483:Alleles; D002561:Cerebrovascular Disorders / Q000097:blood / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D019038:Platelet Glycoprotein GPIb-IX Complex