title: Peri-optic nerve infiltration during leukaemic relapse: MRI diagnosis.
abstract: BACKGROUND
  A 10-year-old boy with a history of acute lymphoblastic leukaemia (ALL), but without previous evidence of central nervous system involvement, presented with seizures 3 years after complete remission.
  
  
  METHODS
  MRI showed bilateral enlargement of the optic nerves despite normal ophthalmological examination.
  
  
  RESULTS
  Only the third cerebrospinal fluid examination showed 2 % blasts without concomitant bone-marrow infiltration. Enlargement of the optic nerves was consistent with bilateral leukaemic peri-optic nerve infiltration. The appearances returned to normal after chemotherapy.
  
  
  CONCLUSIONS
  The optic nerves are a potential site of relapse in patients with systemic and meningeal ALL, even in the absence of ophthalmological signs.
authors.affiliation: Department of Imaging, Hôpital Universitaire des Enfants Reine Fabiola, 15 Avenue J. J. Crocq, B-1020 Brussels, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Madani
authors.forename: C
authors.initials: C
authors.lastname: Christophe
authors.forename: A
authors.initials: A
authors.lastname: Ferster
authors.forename: B
authors.initials: B
authors.lastname: Dan
mesh_terms: D002648:Child; D006801:Humans; D017254:Leukemic Infiltration / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D009900:Optic Nerve / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D012008:Recurrence