A scheme for automatically building three-dimensional morphometric anatomical atlases: application to a skull atlas.
We present a general scheme for automatically building a morphometric anatomical atlas. We detail each stage of the method, including the non-rigid registration algorithm, three-dimensional line averaging and statistical processes. We apply the method to obtain a quantitative atlas of skull crest lines. Finally, we use the resulting atlas to study a craniofacial disease; we show how we can obtain qualitative and quantitative results by contrasting a skull affected by a mandible deformation with the atlas.
Subsol
G
G
INRIA, Epidaure Project, Sophia Antipolis, France. Gerard.Subsol@sophia.inria.fr
Thirion
J P
JP
Ayache
N
N
D000465:Algorithms; D000716:Anatomy, Artistic / Q000379:methods* / Q000706:statistics & numerical data; D019465:Craniofacial Abnormalities / Q000473:pathology; D003936:Diagnosis, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D008488:Medical Illustration; D012886:Skull / Q000033:anatomy & histology*