[The effect of histochrome on the lipid peroxidation indices during the surgical treatment of patients with ischemic heart disease of different functional classes].
The cardioprotector effect of the antioxidant histochrom was studied during surgical creation of an aortocoronary shunt in patients suffering from ischemic heart disease with angina pectoris of different functional classes (FC). The initial content of lipid peroxidation (LPO) products in the blood of patients with angina pectoris of functional class II was much lower than that in patients with angina pectoris of FC IV. This difference disappeared practically after intravenous infusion of histochrom in the pre- and postoperative period. Besides with the use of histochrom the incidence of early postoperative complications reduced significantly.
Afanas'ev
S A
SA
Department of Experimental Cardiology, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia.
Lasukova
T V
TV
Cherniavskiĭ
A M
AM
Vecherskiĭ
Iu Iu
IuIu
Ponomarenko
I V
IV
D000787:Angina Pectoris / Q000097:blood / Q000145:classification / Q000188:drug therapy / Q000601:surgery; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D017024:Chemotherapy, Adjuvant; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000097:blood / Q000145:classification / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000145:classification / Q000188:drug therapy* / Q000601:surgery; D009285:Naphthoquinones / Q000008:administration & dosage* / Q000494:pharmacology; D005082:Physical Exertion; D011182:Postoperative Care; D011300:Preoperative Care; D013997:Time Factors
D000975:Antioxidants; D009285:Naphthoquinones; C103614:histochrome