title: Deletion/insertion polymorphism in the angiotension-converting enzyme gene as a risk factor in the Slovenian patients with coronary heart disease.
abstract: The angiotensin-converting enzyme (ACE) plays by degradation of angiotensin I and bradykinin, an important role in modulations of smooth muscle proliferation and vascular tone. Typical plasma levels of ACE accompany the I/D polymorphism; however, a controversy exists as to whether the DD genotype of the ACE polymorphism affects the risk for the development of coronary heart disease (CHD). We compared the I/D polymorphism in 171 Slovenian CHD patients that were younger than 55 years with 134 healthy control individuals. The DD genotype is associated with a 2.3-fold increase in the risk for CHD.
authors.affiliation: Department of Obstetrics and Gynecology, UMC Ljubljana, Slovenia.
authors.forename: B
authors.initials: B
authors.lastname: Peterlin
authors.forename: D
authors.initials: D
authors.lastname: Petrovic
authors.forename: M
authors.initials: M
authors.lastname: Zorc
authors.forename: I
authors.initials: I
authors.lastname: Keber
mesh_terms: D003327:Coronary Disease / Q000235:genetics*; D004251:DNA Transposable Elements; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012016:Reference Values; D017524:Slovenia
chemical_list: D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A