Follow-up study of peritoneal fluid kinetics in infants and children on peritoneal dialysis.
OBJECTIVE
To study longitudinal changes in transcapillary ultrafiltration (TCUF) and marker clearance (MC), as a reflection of lymphatic absorption, in children on peritoneal dialysis (PD). To present data on fluid kinetics in infants younger than 2.5 years, using an intraperitoneal volume of 1200 mL/m2 body surface area (BSA).


METHODS
The study involved a 4-hour dwell of 1200 mL/m2 BSA of dialysis fluid containing 3.86% glucose with Dextran 70 as volume marker. Cumulative TCUF and cumulative MC were measured.


METHODS
A tertiary-care university hospital.


METHODS
A follow-up period of 33 months of serial (1 - 4) peritoneal equilibration tests (PETs) was studied in 20 children with a median age of 6.4 years (range 2.1 - 15.4 years). Fluid kinetics in 5 additional infants with a median age of 1.4 years (range 0.5 - 2.5 years) was measured.


RESULTS
Cumulative TCUF was 1041 mL/1.73 m2 at 1 - 3 months after start of PD, 1026 mL/1.73 m2 at 7 - 9 months, 1021 mL/1.73 m2 at 11 - 13 months, and 756 mL/1.73 m2 at 26 - 33 months (NS). Cumulative MC was 235 mL/1.73 m2 at 1 - 3 months after start of PD, 311 mL/1.73 m2 at 7 - 9 months, 395 mL/1.73 m2 at 11 - 13 months, and 509 mL/1.73 m2 at 26 - 33 months (NS). In infants, cumulative TCUF was 755 +/- 237 mL/1.73 m2; cumulative MC was 400 +/- 214 mL/1.73 m2.


CONCLUSIONS
Transcapillary ultrafiltration and marker clearance do not change in children > 2.5 years during the period studied. Fluid kinetics does not differ between infants < 2.5 years and older children when intraperitoneal volumes of 1200 mL/m2 BSA are used.
de Boer
A W
AW
Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
van Schaijk
T C
TC
Willems
H L
HL
de Haan
A F
AF
Monnens
L A
LA
Schröder
C H
CH
D000042:Absorption; D000293:Adolescent; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D001830:Body Surface Area; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000032:analysis / Q000097:blood; D003911:Dextrans / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics; D015314:Dialysis Solutions / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D005947:Glucose / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D006801:Humans; D008137:Longitudinal Studies; D008196:Lymph / Q000378:metabolism; D008297:Male; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism; D012189:Retrospective Studies; D014462:Ultrafiltration
D001786:Blood Glucose; D003911:Dextrans; D015314:Dialysis Solutions; D003404:Creatinine; D005947:Glucose