A new depsipeptide from the sacoglossan mollusk Elysia ornata and the green alga Bryopsis species.
A new cyclic depsipeptide, kahalalide O (1), was isolated from the sacoglossan Elysia ornata and its algal diet Bryopsis sp. The structure was elucidated primarily by NMR and MS spectral methods, and the stereochemistry of the amino acid residues was determined by chiral HPLC and Marfey analyses. Unlike the related metabolite kahalalide F, which is in development as a potential anticancer agent, kahalalide O (1) was inactive in arresting the growth of P-388, A549, HT29, and MEL28 cancer cell lines in vitro.
Horgen
F D
FD
Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822, USA.
delos Santos
D B
DB
Goetz
G
G
Sakamoto
B
B
Kan
Y
Y
Nagai
H
H
Scheuer
P J
PJ
D000818:Animals; D000460:Chlorophyta / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D008974:Mollusca / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011487:Protein Conformation; D014407:Tumor Cells, Cultured
D047630:Depsipeptides; D010456:Peptides, Cyclic; C404717:kahalalide O