Glioblastoma causing granulocytosis by secretion of granulocyte-colony-stimulating factor.
We describe a patient with a glioblastoma multiforme with excessive granulocytosis in the peripheral blood. Shown at both protein and mRNA levels, the tumor produced very high levels of granulocyte-colony-stimulating factor (G-CSF). G-CSF is a growth factor that induces the recruitment of granulocytes. The paraneoplastic phenomenon described here partly mimicked a brain abscess. Production of G-CSF by (brain) tumor cells might be related to the granulocytosis common in malignant disease.
Hintzen
R Q
RQ
Department of Neurology, Leiden University Medical Center, The Netherlands. rhintzen@xs4all.nl
Voormolen
J
J
Sonneveld
P
P
van Duinen
S G
SG
D000368:Aged; D001922:Brain Abscess / Q000175:diagnosis; D001932:Brain Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D003937:Diagnosis, Differential; D005909:Glioblastoma / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007964:Leukocytosis / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male
D016179:Granulocyte Colony-Stimulating Factor