title: Aortic atherosclerosis at middle age predicts cerebral white matter lesions in the elderly.
abstract: OBJECTIVE
  MRI scans of the brains of elderly people frequently show white matter lesions. Clinically, these lesions are associated with cognitive impairment and dementia. A relation between atherosclerosis and white matter lesions was found in some small cross-sectional studies. However, atherosclerosis is a gradual process that starts early in life. We investigated the longitudinal association between aortic atherosclerosis assessed during midlife and late life and cerebral white matter lesions.
  
  
  METHODS
  We randomly sampled subjects between 60 and 90 years old from 2 population-based follow-up studies in which subjects had their baseline examinations in 1975 to 1978 (midlife) and in 1990 to 1993 (late life). In 1995 to 1996, subjects underwent 1.5-T MRI scanning; white matter lesions were rated in the deep subcortical and periventricular regions separately. Aortic atherosclerosis was assessed on abdominal radiographs that were obtained from 276 subjects in midlife and 531 subjects in late life.
  
  
  RESULTS
  The presence of aortic atherosclerosis during midlife was significantly associated with the presence of periventricular white matter lesions approximately 20 years later (adjusted relative risk, 2.4; 95% CI, 1.2 to 5.0); the relative risks increased linearly with the severity of aortic atherosclerosis. No association was found between midlife aortic atherosclerosis and subcortical white matter lesions (adjusted relative risk, 1.1; 95% CI, 0.5 to 2.3) or between late-life aortic atherosclerosis and white matter lesions.
  
  
  CONCLUSIONS
  The pathogenetic process that leads to cerebral periventricular white matter lesions starts already in or before midlife. The critical period for intervention directed at prevention of white matter lesions and its cognitive consequences may be long before these lesions become clinically detectable.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
authors.forename: F E
authors.initials: FE
authors.lastname: de Leeuw
authors.forename: J C
authors.initials: JC
authors.lastname: De Groot
authors.forename: M
authors.initials: M
authors.lastname: Oudkerk
authors.forename: J C
authors.initials: JC
authors.lastname: Witteman
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: J
authors.initials: J
authors.lastname: van Gijn
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001011:Aorta / Q000473:pathology / Q000503:physiopathology; D001161:Arteriosclerosis / Q000150:complications*; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors