title: Molecular motors: the driving force behind mammalian left-right development.
abstract: The molecular motors dynein and kinesin are large protein complexes that convert the energy generated by ATP hydrolysis into directional movement along the microtubule cytoskeleton. They are required for a myriad of cellular processes, including mitotic spindle movement, axonal and vesicular transport, and ciliary beating. Recently, it has been shown that, in addition, they have a unique role during embryonic patterning: they are required to orient and establish the left-right axis in early vertebrate development.
authors.affiliation: Research Dept, Shriners Hospital for Children, Cincinnati, OH 45229, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Supp
authors.forename: S S
authors.initials: SS
authors.lastname: Potter
authors.forename: M
authors.initials: M
authors.lastname: Brueckner
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000187:drug effects* / Q000502:physiology; D004398:Dyneins / Q000494:pharmacology / Q000502:physiology; D005314:Embryonic and Fetal Development; D006801:Humans; D016547:Kinesins / Q000494:pharmacology / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000494:pharmacology / Q000502:physiology*
chemical_list: D008869:Microtubule-Associated Proteins; D004398:Dyneins; D016547:Kinesins