[Functional state of glutamate receptors during treatment with ethanol].
A growing bulk of experimental data indicates that change of certain neurotransmitter receptors and voltage-dependent ion cannels are characteristic manifestations accompanying ethanol consumption. A likely target for ethanol effects is the glutamate receptors. Glutamate is one of major excitatory neurotransmitter in the mammalian brain. While the acute application of ethanol inhibits glutamate-induced cationic currents, chronic treatment with ethanol leads to an up-regulation of glutamate receptors.
Golovko
S I
SI
North-west Regional Medical Centre Bekhterev, Saint Petersburg, Russia.
Zefirov
S Iu
SIu
Golovko
A I
AI
Shpilenia
L S
LS
Nekrasov
Iu A
IuA
Romanenko
O I
OI
D000437:Alcoholism / Q000503:physiopathology*; D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*
D017470:Receptors, Glutamate; D000431:Ethanol