title: Sentinel node biopsy in early vulvar cancer.
abstract: Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This study evaluates the feasibility of the surgical identification of sentinel groin nodes using lymphoscintigraphy and a gamma-detecting probe in patients with early vulvar cancer. Technetium-99m-labelled colloid human albumin was administered perilesionally in 37 patients with invasive epidermoid vulvar cancer (T1-T2) and lymphoscintigraphy performed the day before surgery. An intraoperative gamma-detecting probe was used to identify sentinel nodes during surgery. A complete inguinofemoral node dissection was then performed. Sentinel nodes were submitted separately to pathologic evaluation. A total of 55 groins were dissected in 37 patients. Localization of the SN was successful in all cases. Eight cases had positive nodes: in all the sentinel node was positive; the sentinel node was the only positive node in five cases. Twenty-nine patients showed negative sentinel nodes: all of them were negative for lymph node metastases. Lymphoscintigraphy and sentinel-node biopsy under gamma-detecting probe guidance proved to be an easy and reliable method for the detection of sentinel node in early vulvar cancer. This technique may represent a true advance in the direction of less aggressive treatments in patients with vulvar cancer.
authors.affiliation: Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: De Cicco
authors.forename: M
authors.initials: M
authors.lastname: Sideri
authors.forename: M
authors.initials: M
authors.lastname: Bartolomei
authors.forename: C
authors.initials: C
authors.lastname: Grana
authors.forename: M
authors.initials: M
authors.lastname: Cremonesi
authors.forename: M
authors.initials: M
authors.lastname: Fiorenza
authors.forename: A
authors.initials: A
authors.lastname: Maggioni
authors.forename: L
authors.initials: L
authors.lastname: Bocciolone
authors.forename: C
authors.initials: C
authors.lastname: Mangioni
authors.forename: N
authors.initials: N
authors.lastname: Colombo
authors.forename: G
authors.initials: G
authors.lastname: Paganelli
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006119:Groin; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D011237:Predictive Value of Tests; D011379:Prognosis; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D014846:Vulvar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*