[Angiotensin II inhibits L-type voltage-dependent Ca(2+)-current in smooth muscle cells from the rat aorta].
Macroscopic voltage-activated L-type Ca2+ currents were blocked by angiotensin II (A11), the effect being inhibited by losartan. A rise in internal Ca2+ evoked by the A11, occurred, losartan being ineffective in these cases. The AT1 receptors seem to be involved in the effect of the A11 on the L-type Ca2+ current in aortic smooth muscle cells.
Serebriakov
V N
VN
Cardiological Research-Industrial Complex, Moscow, Russia.
Takeda
K
K
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000502:physiology; D020746:Calcium Channels, L-Type / Q000502:physiology*; D020747:Calcium Channels, T-Type / Q000502:physiology; D002478:Cells, Cultured; D004558:Electric Stimulation; D004594:Electrophysiology; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D020746:Calcium Channels, L-Type; D020747:Calcium Channels, T-Type; D014662:Vasoconstrictor Agents; D000804:Angiotensin II