Astrovirus enteritis in a chronic lymphocytic leukemia patient treated with fludarabine monophosphate.
We report on a case of severe astrovirus gastroenteritis in a chronic lymphocytic leukemia (CLL) patient treated with fludarabine monophosphate (FAMP). Astrovirus was detected in stools using both an immunoenzymatic assay and an electronic microscopy analysis. Treatment consisted in symptomatic care and the outcome was favorable. Astrovirus infection might constitute a common etiology of gastroenteritis in patients with hematologic malignancies that have been severely immunocompromised with FAMP or other purine analogues, and therefore should be more systematically investigated.
Coppo
P
P
Service d'Immuno-Hématologie, Hôpital Saint-Louis, Paris, France.
Scieux
C
C
Ferchal
F
F
Clauvel
J
J
Lassoued
K
K
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D019350:Astroviridae Infections; D005243:Feces / Q000821:virology; D005759:Gastroenteritis / Q000150:complications* / Q000821:virology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D001257:Mamastrovirus; D008854:Microscopy, Electron; D008875:Middle Aged; D001084:Vidarabine Phosphate / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000964:Antimetabolites, Antineoplastic; D007166:Immunosuppressive Agents; D001084:Vidarabine Phosphate; C042382:fludarabine phosphate