A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species.
A new sterol, (22R,23R,24R)-5alpha,8alpha-epidioxy-22, 23-methylene-24-methylcholest-6-en-3beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp. The structure of metabolite 1 was determined by spectral analysis. Cytotoxicity of sterols 1-3 toward various cancer cell lines is also reported.
Sheu
J H
JH
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China. sheu@mail.nsysu.edu.tw
Chang
K C
KC
Duh
C Y
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
C404716:5,8-epidioxy-22,23-methylene-24-methylcholest-6-en-3-ol; D000970:Antineoplastic Agents; D002784:Cholesterol