title: CD95: more than just a death factor?
abstract: The CD95 protein delivers crucial signals for lymphocyte death, and may also negatively regulate T-lymphocyte activation by preventing the influx of calcium ions from the cell's exterior. The block in calcium-ion influx occurs through the activation of acidic sphingomyelinase and the release of ceramide, a metabolite that can also induce cell death.
authors.forename: A O
authors.initials: AO
authors.lastname: Hueber
mesh_terms: D020013:Calcium Signaling; D016923:Cell Death; D008213:Lymphocyte Activation; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D011948:Receptors, Antigen, T-Cell; D019014:fas Receptor