title: DNA defects target the centrosome.
abstract: When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to segregate chromosomes. These defects may result from the workings of a surveillance mechanism that acts to cull irreparable nuclei.
authors.forename: T T
authors.initials: TT
authors.lastname: Su
authors.forename: S J
authors.initials: SJ
authors.lastname: Vidwans
mesh_terms: D000818:Animals; D018385:Centrosome / Q000502:physiology*; D004249:DNA Damage; D004330:Drosophila / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D008957:Models, Genetic