title: Lectin-Mediated Drug Targeting: Discrimination of Carbohydrate-Mediated Cellular Uptake between Tumor and Liver Cells with Neoglycoconjugates Carrying Fucose Epitopes Regioselectively Modified in the 3-Position.
abstract: The circumvention of efficient "carbohydrate traps" in the liver is required for targeting glycoconjugates on tumor cells. As shown in the model system of bovine serum albumin (BSA) conjugates, the nature of R(1)-R(3) of the fucose epitope plays an important role in the discrimination of cellular uptake between tumor and liver cells as well as in the cytotoxic activity.
authors.affiliation: Bayer AG, Zentrale Forschung, Wirkstoff-Forschung, Gebäude, D-51368 Leverkusen (Germany).
authors.initials: HG
authors.lastname: Lerchen
authors.initials: J
authors.lastname: Baumgarten
authors.initials: N
authors.lastname: Piel
authors.initials: V
authors.lastname: Kolb-Bachofen