title: Inhibition of nitric oxide release by an aqueous extract of Tinospora tuberculata.
abstract: An aqueous extract of Tinospora tuberculata stems was found to scavenge nitric oxide (NO) in vitro in both cell and cell-free systems. When the aqueous extract was added to lipopolysaccharide-stimulated murine macrophages, it inhibited NO release dose-dependently, and similar activity was found in a cell-free system using sodium nitroprusside as a NO donor. These findings may help to explain, in part, certain pharmacological activities of Tinospora tuberculata.
authors.affiliation: Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yokozawa
authors.forename: T S
authors.initials: TS
authors.lastname: Wang
authors.forename: C P
authors.initials: CP
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Hattori
mesh_terms: D000818:Animals; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D009569:Nitric Oxide