title: Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations.
abstract: This study was designed to evaluate 2 combinations for immobilization of bison. Seven wood bison received 1.5 mg/kg body weight (BW) of xylazine HCl + 1.5 mg/kg BW of zolazepam HCl and 1.5 mg/kg BW of tiletamine HCl on one occasion. The bison received 60 micrograms/kg BW of medetomidine HCl + 0.6 mg/kg BW of zolazepam HCl and 0.6 mg/kg BW of tiletamine HCL on another occasion. Xylazine was antagonized with 3 mg/kg BW of tolazoline HCl and medetomidine HCl was antagonized with 180 micrograms/kg (BW) of atipamezole HCl. Temporal characteristics of immobilization and physiological effects (acid-base status, thermoregulatory, cardiovascular, and respiratory effects) of the drug combinations were compared. Induction was significantly faster with xylazine HCl-zolazepam HCl/tiletamine HCl. Recovery following antagonist administration was significantly faster with medetomidine HCl-zolazepam HCl/tiletamine HCl. The average drug volumes required were 7.00 mL of xylazine HCl-zolazepam HCl/tiletamine HCL and 2.78 mL of medetomidine HCl-zolazepam HCl/tiletamine HCl. Hypoxemia, hypercarbia, and rumenal tympany were the major adverse effects with both drug combinations.
authors.affiliation: Department of Veterinary Anesthesiology, Radiology and Surgery, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
authors.forename: N A
authors.initials: NA
authors.lastname: Caulkett
authors.forename: M R
authors.initials: MR
authors.lastname: Cattet
authors.forename: S
authors.initials: S
authors.lastname: Cantwell
authors.forename: N
authors.initials: N
authors.lastname: Cool
authors.forename: W
authors.initials: W
authors.lastname: Olsen
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000829:Animals, Domestic; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001569:Benzodiazepines; D016164:Bison; D004359:Drug Therapy, Combination; D008297:Male; D020926:Medetomidine / Q000008:administration & dosage / Q000627:therapeutic use*; D013992:Tiletamine / Q000008:administration & dosage / Q000627:therapeutic use*; D014730:Veterinary Medicine / Q000379:methods; D014991:Xylazine / Q000008:administration & dosage / Q000627:therapeutic use*; D015041:Zolazepam / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000316:Adrenergic alpha-Agonists; D018712:Analgesics, Non-Narcotic; D000778:Anesthetics, Dissociative; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D014991:Xylazine; D013992:Tiletamine; D015041:Zolazepam; D020926:Medetomidine