Association of sex hormone-binding globulin and insulin resistance among Japanese-American subjects.
An association between sex hormone-binding globulin (SHBG) and insulin resistance expressed by the homeostasis model (HOMA-R), and the significance of both variables as risk factors for the development of type 2 diabetes were investigated in 483 Japanese-American subjects. The serum SHBG level was significantly higher in women (68.7 nmol/l) than in men (45.1 nmol/l). This difference was also significant independently of age, body mass index (BMI), waist to hip ratio (WHR), and HOMA-R. When multiple regression analysis was performed after adjustment for age and BMI, SHBG was not correlated with HOMA-R in men. In women, SHBG was not significantly correlated with HOMA-R after adjustment for age, BMI, and WHR. In a 3-year prospective analysis, HOMA-R was significantly higher in converters to type 2 diabetes than non-converters in both men and women which was independent of age, BMI and WHR. However, after adjusting these variables, SHBG was not a significant risk factor either in men or women. These results indicate that SHBG might be related to insulin resistance secondarily via BMI and/or WHR in both men and women among Japanese-Americans. HOMA-R is a useful index for both men and women as a risk factor of type 2 diabetes when only fasting blood samples can be obtained.
Okubo
M
M
Second Department of Internal AMedicine, Hiroshima University School of Medicine, Japan. ohkubo@mcai.med.hiroshima-u.ac.jp
Tokui
M
M
Egusa
G
G
Yamakido
M
M
D000368:Aged; D001213:Asian; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology*; D004198:Disease Susceptibility; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D014481:United States
D012738:Sex Hormone-Binding Globulin