title: Pathological prognostic factors in a series of 137 stage I TNM/UICC endometrial carcinomas.
abstract: OBJECTIVE
  We report on the long-term results of combination surgery-radiotherapy in cT1 carcinoma of the endometrium according to prognostic factors.
  
  
  METHODS
  From 1974 to 1993, 130 women suffering from cT1Nx-O Mo endometrial carcinoma, underwent surgical resection. The median age was 62 years. Thirteen received pre-operative irradiation, two pre-operative brachytherapy followed by post-operative external irradiation and 115 patients (88.35%) underwent post-operative irradiation therapy by brachytherapy or external beam irradiation.
  
  
  RESULTS
  The median follow-up is 67 months. Overall and specific survival rates for patients with cT1pT1 tumours were 71.1 and 85% at 10 years. For overall survival, lymph node invasion was the most powerful prognostic factor in the multivariate analysis (P = 0.02). If lymph node invasion is not taken into account, the WHO histological grade exerts a significant prognostic impact (P = 0.001).
  
  
  CONCLUSIONS
  For stage cT1 endometrial carcinoma, primary surgery allows radiotherapy to be adjusted according to the WHO histological grade, myometrial invasion and the pelvic lymph node status.
authors.affiliation: Service de Cancérologie-Radiothérapie, CHU Grenoble, France.
authors.forename: M
authors.initials: M
authors.lastname: Bolla
authors.forename: J
authors.initials: J
authors.lastname: de Cornulier
authors.forename: E
authors.initials: E
authors.lastname: Berland
authors.forename: M
authors.initials: M
authors.lastname: Colonna
authors.forename: X
authors.initials: X
authors.lastname: Artignan
authors.forename: D
authors.initials: D
authors.lastname: Pasquier
authors.forename: J
authors.initials: J
authors.lastname: Salvat
authors.forename: E
authors.initials: E
authors.lastname: Chirpaz
authors.forename: C
authors.initials: C
authors.lastname: Garnier
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D002277:Carcinoma / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D009215:Myometrium / Q000473:pathology; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010388:Pelvis; D011379:Prognosis; D015996:Survival Rate