Embryo development, pregnancy and twin delivery after microinjection of 'stump' spermatozoa.
Intracytoplasmic sperm injection was performed with immotile spermatozoa affected by tail 'stump' defect, and resulted in normal fertilization, embryo transfer and pregnancy in a 35-year-old female. The husband had a consanguineous ancestry. Two healthy babies, a male and a female, were born and this confirms that male infertility due to certain genetic sperm defects can be overcome by the intracytoplasmic sperm injection-assisted reproduction technique. The likely genetic origin of this sperm defect and the probability of the male offspring inheriting this sperm defect should be considered. The fertilization ability of stump spermatozoa, microinjected into the oocyte, is explained on the basis of experience from our previous research.
Favero
R
R
ARC-STER Centro Studi per la Terapia della Sterilità di Coppia, CECOS Italia, Mestre, Italy.
Rizzo
F
F
Baccetti
B
B
Piomboni
P
P
D000328:Adult; D004624:Embryo Transfer; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D013081:Sperm Motility; D013082:Sperm Tail; D013094:Spermatozoa / Q000002:abnormalities*; D014427:Twins