Grb10 proteins in insulin-like growth factor and insulin receptor signaling (review).
The adapter protein Grb10 belongs to a superfamily of related proteins that include Grb7, Grb14 and the Caenorhabtidis elegans Mig10. The available data on Grb10 proteins suggest a role of these adapters in signaling downstream of several receptor tyrosine kinases. In the present review the focus is on the interaction between Grb10 proteins and the insulin-like growth factor receptor/insulin receptor, and the role of Grb10 in IGF-I/insulin-induced mitogenesis is discussed, considering that the data available are also partially discordant.
Morrione
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Kimmel Cancer Center, Thomas Jefferson University, 606 Bluemle Life Sciences Building, Philadelphia, PA 19107-5541, USA.
D000818:Animals; D002455:Cell Division; D051383:GRB10 Adaptor Protein; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D011506:Proteins; D051383:GRB10 Adaptor Protein; D007334:Insulin-Like Growth Factor I; D011972:Receptor, Insulin