title: Exophthalmos, pretibial myxedema, osteoarthropathy syndrome associated with papillary fibroelastoma in the left ventricle.
abstract: EMO syndrome, a rare complication of Graves' disease, exhibits exophthalmos, pretibial myxedema, and osteoarthropathy. The presence of functional thyrotropin receptors (TSHR) in adipocytes and osteoblasts, both of which we have recently observed, may be related to these extrathyroidal manifestations of Graves' disease. In addition, the expression of TSHR in the heart has recently been reported. We describe here a patient with Graves' disease exhibiting EMO syndrome with a papillary fibroelastoma in the left ventricle. Pathological examinations showed that the fibroelastoma contained Alcian blue-stained mucinous materials that were also observed in the subcutaneous tissue of pretibial myxedema.
authors.affiliation: The Third Department of Internal Medicine, Yamanashi Medical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Shimura
authors.forename: K
authors.initials: K
authors.lastname: Haraguchi
authors.forename: N
authors.initials: N
authors.lastname: Harii
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: S
authors.initials: S
authors.lastname: Hosaka
authors.forename: S
authors.initials: S
authors.lastname: Yoshii
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: T
authors.initials: T
authors.lastname: Onaya
mesh_terms: D005350:Fibroma / Q000150:complications* / Q000473:pathology; D006111:Graves Disease / Q000150:complications*; D006338:Heart Neoplasms / Q000150:complications* / Q000473:pathology; D006352:Heart Ventricles; D006801:Humans; D007868:Leg Dermatoses / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009230:Myxedema / Q000150:complications*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology*; D013577:Syndrome