title: [Cytological screening of uterine cervical cancer by samples in liquid medium (CytoRich). Preliminary study of a series of 111 292 patients].
abstract: We report on the preliminary results of a series of 111,292 patients who benefited from a liquid medium sample (CytoRich) for cervical cancer screening. The number of dubious or limited smears was reduced by 0.03% and 0.53% respectively. The junction zone was better explored, and metaplastic changes were observed in 35.71% of the cases. This method improved the identification of low-grade lesions by +56% (2751/111,292; 2.47%) and of high-grade lesions by +75% (860/111,292; 0.77%), with a reduction in the number of ASCUS/AGUS by -44% (2065/111,292; 1.85%). This preliminary study confirms the results already published. The results demonstrating cytohistological correlation should prove to be a decisive factor, enabling the testing of the sensitivity and specificity of this technique. It will then be possible to envisage a future 'new paradigm' for screening cervical cancer as the result of a liquid medium sample, computer-assisted screening and HPV viral identification by Hybrid capture II.
authors.forename: J
authors.initials: J
authors.lastname: Saurel
authors.forename: M
authors.initials: M
authors.lastname: Rabreau
authors.forename: M
authors.initials: M
authors.lastname: Landi
authors.forename: C
authors.initials: C
authors.lastname: Bondu
authors.forename: G
authors.initials: G
authors.lastname: Montoya
authors.forename: C
authors.initials: C
authors.lastname: Morancé
authors.forename: M
authors.initials: M
authors.lastname: Auber
authors.forename: N
authors.initials: N
authors.lastname: Percheron
authors.forename: M
authors.initials: M
authors.lastname: Santa-Maria
authors.forename: M
authors.initials: M
authors.lastname: Bec
authors.forename: M J
authors.initials: MJ
authors.lastname: Berteau
authors.forename: E
authors.initials: E
authors.lastname: Muller
authors.forename: C
authors.initials: C
authors.lastname: Gominet
authors.forename: S
authors.initials: S
authors.lastname: Besserves
authors.forename: E
authors.initials: E
authors.lastname: Thomas
mesh_terms: D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D006801:Humans; D012680:Sensitivity and Specificity; D012996:Solutions; D013048:Specimen Handling / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014626:Vaginal Smears / Q000379:methods*
chemical_list: D012996:Solutions