title: Cytoprotection and intracellular calcium.
abstract: It seems that prostacyclin has an increasing effect on gastric mucosal (antral and fundic) calmodulin level in rats. Using either the calcium channel blocker verapamil or anti-calmodulin drugs (diazepam, trifluoperazine,) the cytoprotective effect of prostacyclin can be inhibited. Therefore, it is probable that calcium ions and calcium-activated calmodulin play a role in the effect of prostacyclin.
authors.affiliation: Laboratory of Clinical Pharmacology, Dept. of Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: G A
authors.initials: GA
authors.lastname: Balint
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019610:Cytoprotection / Q000187:drug effects / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D005748:Gastric Fundus; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D011706:Pyloric Antrum; D051381:Rats; D017208:Rats, Wistar; D014268:Trifluoperazine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002147:Calmodulin; D014268:Trifluoperazine; D014700:Verapamil; D011464:Epoprostenol; D003975:Diazepam; D002118:Calcium