A note on the functions of bc1-2 in human solid tumors in situ.
Dual functions of bc1-2 product, (1) inhibition of apoptosis and (2) inhibition of cell growth, were analyzed in human endometrial adenocarcinoma tissue using serial tissue sections and immunohistochemical and histochemical procedures. As conclusion, bc1-2 product was speculated to have at least two functions; (1) suppression of apoptosis of cells in G0 phase, and (2) blocking the entrance of G0 cells into cell division cycle.
Kuwashima
Y
Y
Department of Laboratory Medicine, Hanyu General Hospital, Saitama, Japan.
D000230:Adenocarcinoma / Q000503:physiopathology*; D016889:Endometrial Neoplasms / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology*
D019253:Proto-Oncogene Proteins c-bcl-2