Intracellular signalling: Is PIP(2) a messenger too?
The phospholipid phosphatidylinositol (4,5) bisphosphate (PIP(2)) has recently been shown to act downstream of the small G proteins Rac and Arf. Different effectors may be employed in each case, suggesting that PIP(2) has multiple signalling roles.
Hinchliffe
K
K
Department of Pharmacology, University of Cambridge, Cambridge, CB2 1QJ, UK. kh224@cam.ac.uk
D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000818:Animals; D002417:Cattle; D019204:GTP-Binding Proteins / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D015398:Signal Transduction; D020744:rac GTP-Binding Proteins / Q000378:metabolism
D019269:Phosphatidylinositol 4,5-Diphosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase; D019204:GTP-Binding Proteins; D020727:ADP-Ribosylation Factors; D020744:rac GTP-Binding Proteins