title: TMC-171A,B,C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282.
abstract: Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
authors.affiliation: Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kohno
authors.forename: Y
authors.initials: Y
authors.lastname: Asai
authors.forename: M
authors.initials: M
authors.lastname: Nishio
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
authors.forename: K
authors.initials: K
authors.lastname: Kawano
authors.forename: H
authors.initials: H
authors.lastname: Hiramatsu
authors.forename: N
authors.initials: N
authors.lastname: Kameda
authors.forename: N
authors.initials: N
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Okuda
authors.forename: S
authors.initials: S
authors.lastname: Komatsubara
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008358:Mannose / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000378:metabolism*; D008968:Molecular Conformation; D014885:Waxes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; C405182:TMC 154; C405183:TMC 171A; C405184:TMC 171B; C405185:TMC 171C; D014885:Waxes; D008358:Mannose