Does the site of intestinal delivery of oleic acid alter the ileal brake response?
Previous work has demonstrated that high doses of oleic acid can activate the ileal brake but the importance of site of delivery has yet to be investigated. The objective of this study was to use modified release capsules to release oleic acid in different regions of the intestine. When tested by in vitro dissolution in pH 6.8 phosphate buffer, one batch released the contents almost immediately, another after around 30 min and the last batch after around 60-70 min. The effect of oleic acid release site on the ileal brake was assessed by the measurement of transit time of radiolabelled non disintegrating tablets by gamma scintigraphy. The results demonstrated that the transit of tablets could be slowed down by oleic acid and therefore it appears the ileal brake can be activated along the entirety of the small intestine.
Dobson
C L
CL
School of Pharmaceutical Sciences, Nottingham University, Nottingham, UK.
Davis
S S
SS
Chauhan
S
S
Sparrow
R A
RA
Wilding
I R
IR
D002214:Capsules; D003692:Delayed-Action Preparations; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007082:Ileum / Q000000981:diagnostic imaging / Q000187:drug effects*; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage* / Q000494:pharmacology*; D011877:Radionuclide Imaging; D013607:Tablets; D013997:Time Factors
D002214:Capsules; D003692:Delayed-Action Preparations; D013607:Tablets; D019301:Oleic Acid