Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia.
A 7-year-old boy with Diamond-Blackfan anemia (DBA) developed lymphoproliferative disease (LPD) after a cord blood transplant (CBT). 3.1 x 107/kg mononuclear cells from an HLA one-locus mismatched CB were transplanted after conditioning with total body irradiation (8 Gy), cyclophosphamide (200 mg/kg) and antithymocyte globulin (10 mg/kg). Complete engraftment occurred on day 33 post transplant. Despite the resolution of grade II graft-versus-host disease (GVHD), he died of lymphoma on day 130 post transplant. The tumor was of donor origin, indicating clonal proliferation of Epstein-Barr virus (EBV)-infected B cells. This is the first report of EBV-LPD after CBT. Post-transplant LPD can be a serious EBV-associated complication of CB grafts. Bone Marrow Transplantation (2000) 25, 209-212.
Ohga
S
S
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Japan.
Kanaya
Y
Y
Maki
H
H
Takada
H
H
Ohshima
K
K
Kanda
M
M
Nomura
A
A
Suminoe
A
A
Matsuzaki
A
A
Hara
T
T
D016913:Blood Component Transfusion / Q000009:adverse effects; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000209:etiology / Q000635:transmission* / Q000821:virology; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications / Q000628:therapy* / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000276:immunology / Q000821:virology; D016332:Fetal Tissue Transplantation / Q000009:adverse effects / Q000276:immunology; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D004854:Herpesvirus 4, Human / Q000502:physiology; D006650:Histocompatibility Testing; D006801:Humans; D016393:Lymphoma, B-Cell / Q000097:blood / Q000209:etiology* / Q000821:virology; D008297:Male; D019172:Transplantation Conditioning / Q000009:adverse effects