[The length-force dependence of vascular smooth muscles and the nitric oxide system in a chronic deficiency of mesostriatal dopamine].
This study investigated the influence of the chronic cerebral dopamine deficiency after 6-hydroxydopamine lesions of dopaminergic mesostriatal system and NO pathways on the length-tension relation in vascular smooth muscles to their distension. Experiments were performed on isolated strips of rat portal vein. The results indicate that the attenuated contraction responses and the increased stiffness of vascular smooth muscles to the distension in a chronic mesostriatal dopamine deficiency. It was found that these responses may be, in part, normalized after a long-term L-arginine administration. The same changes were marked in the responses of intact vascular strips after the inhibition of NO-synthase activity and L-arginine perfusion. It has been suggested that, in a chronic mesostriatal dopamine deficiency, the reduced vascular reactivity was due to the decreasing of NO synthesis by endothelium and L-arginine could be used in the treatment of these vascular disorders.
Sahach
V F
VF
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Tkachenko
M M
MM
Shapoval
M V
MV
D018663:Adrenergic Agents; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000172:deficiency*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D016627:Oxidopamine; D011169:Portal Vein / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D018663:Adrenergic Agents; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D016627:Oxidopamine; D001120:Arginine; D019331:NG-Nitroarginine Methyl Ester; D004298:Dopamine