Enantiomer separation of alpha-ionone using gas chromatography with cyclodextrin derivatives as chiral stationary phases.
The gas chromatographic enantiomer separation of alpha-ionone was studied with three different chiral stationary phases using as chiral selectors: (1) heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin, dissolved in polysiloxane PS-086, (2) octakis(2,6-di-O-pentyl-3-O-trifluoroacetyl)-gamma-cyclodextrin and (3) octakis(2,6-di-O-pentyl-3-O-butanoyl)-gamma-cyclodextrin, both dissolved in polysiloxane SE-54. The influence of the concentration of the chiral selector in the polysiloxane, coated on Chromosorb P AW-DMCS 80-100 mesh, is described and discussed, as well as the effect of Chromosorb loading. The feasibility of the preparative gas chromatographic separation of the enantiomers of alpha-ionone is considered; in order to provide a term of comparison, the estimated performances are compared with those achieved in the separation of the enantiomers of the inhalation anaesthetic enflurane.
Quattrini
F
F
Laboratorium für Technische Chemie, ETH Zürich, Switzerland.
Biressi
G
G
Juza
M
M
Mazzotti
M
M
Fuganti
C
C
Morbidelli
M
M
D018685:Anesthetics, Inhalation / Q000302:isolation & purification; D002849:Chromatography, Gas / Q000379:methods*; D003505:Cyclodextrins; D004737:Enflurane / Q000302:isolation & purification; D007202:Indicators and Reagents; D008433:Mathematics; D045792:Norisoprenoids; D013237:Stereoisomerism; D013729:Terpenes / Q000302:isolation & purification*
D018685:Anesthetics, Inhalation; D003505:Cyclodextrins; D007202:Indicators and Reagents; D045792:Norisoprenoids; D013729:Terpenes; D004737:Enflurane; C011879:alpha-ionone