Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients. Canadian Collaborative Study Group.
The objective of this study was to investigate genes involved in the metabolism and function of vitamin D as candidate genes for genetic susceptibility to MS. Restriction fragment length polymorphisms and highly polymorphic microsatellite markers within or very close to the 1,25(OH)2D3 receptor (VDR) [12q14], the vitamin D binding protein (DBP) [4q12], and the 25(OH)D2 1alpha-hydroxylase [12q13] loci were analyzed for linkage or association with MS. We found no evidence for linkage or association of these candidate genes with MS in the Canadian population.
Steckley
J L
JL
Wellcome Trust Centre for Human Genetics, University of Oxford, England.
Dyment
D A
DA
Sadovnick
A D
AD
Risch
N
N
Hayes
C
C
Ebers
G C
GC
D000483:Alleles; D002170:Canada; D008040:Genetic Linkage / Q000235:genetics; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D014807:Vitamin D / Q000235:genetics*
D014807:Vitamin D