Failure of elimination of paternal mitochondrial DNA in abnormal embryos.
Paternal mitochondrial DNA is normally eliminated from mammalian embryos. We have shown the presence of paternal mtDNA at the blastocyst stage in some abnormal human embryos.
St John
J
J
Sakkas
D
D
Dimitriadi
K
K
Barnes
A
A
Maclin
V
V
Ramey
J
J
Barratt
C
C
De Jonge
C
C
D001755:Blastocyst; D004272:DNA, Mitochondrial / Q000235:genetics; D004622:Embryo, Mammalian; D005220:Fathers; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic
D004272:DNA, Mitochondrial