Molecular control of nitric oxide synthases in the cardiovascular system.
Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the regulation of the three nitric oxide synthase isoforms in the cardiovascular system are examined at molecular and cellular levels. In addition, recent information gleaned from the use of NOS knockout mice are discussed.
Papapetropoulos
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Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
Rudic
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Sessa
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D000818:Animals; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000201:enzymology; D002319:Cardiovascular System / Q000378:metabolism*; D002490:Central Nervous System / Q000201:enzymology; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007107:Immune System / Q000201:enzymology; D051379:Mice; D018345:Mice, Knockout; D009389:Neovascularization, Pathologic; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; D051381:Rats; D014666:Vasomotor System / Q000201:enzymology
D009569:Nitric Oxide; C496320:NOS1 protein, human; C496319:NOS2 protein, human; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D052250:Nitric Oxide Synthase Type III; C496321:Nos1 protein, mouse; C496322:Nos1 protein, rat; C496317:Nos2 protein, mouse; C496318:Nos2 protein, rat; C496315:Nos3 protein, mouse; C496316:Nos3 protein, rat