[A study of genetic epidemiology on child bronchial asthma].
OBJECTIVE
To examine the relationship between child bronchial asthma and genetic fastor.


METHODS
A case-control study including 372 pedigree was carried out.


RESULTS
Child bronchial asthma had obvious familiar clustering (chi 2 = 24.8, P < 0.01). The prevalence rate of the first and the second degree relatives of proband was significally higher than that of the controls. The segregation ration of asthma was 0.14 (95% CL 0.098-0.18). The h2 of the first and second degree relatives of asthma were 78.18% and 55.02%, of which 83.64% for female and 73.48% for male.


CONCLUSIONS
The genetic model of asthma belonged to polygenetics. Genetic fastor was a main risk fastor for asthma, especially for female patients.
Tang
G
G
Anhui Medical University, Hefei.
Li
T
T
Zhang
D
D
D000293:Adolescent; D001249:Asthma / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012307:Risk Factors