[Antiallergic effects of tranilast in rats and guinea pigs].
Tranilast is an anti-allergic drug. In this study, we made a comparision between the Tranilast synthized by School of Pharmacy WCUMS using new technical and the Tranilast produced by Kissei pharmaceutical Co. LTD, Japan on their antiallergic effects. We found that the two tranilasts had the same antiallergic effects: (1) they inhibit the passive cutaneous anaphylaxis in sensitized rats with the dose of 100, 200 mg/kg(P < 0.01); (2) they inhibit degranulation of mast cells in sensitized rats (10(-5) and 10(-4) mol/L) (P < 0.05); (3) they inhibit schultz-Dale response in sensitized guinea pigs (10(-3) and 10(-4) (mol/L); (4) the inhibit SRS-A release from the lung of sensitized guinea pigs(10(-3), 10(-4) and 10(-5) mol/L) (P < 0.05); and (5) they inhibit the contraction of ileum of normal guinea pigs induced by SRS-A(10(-4) and 10(-3) mol/L).
Chen
J
J
Department of Pharmacology, School of Basic Medical Sciences, Chengdu.
Cai
S
S
Ye
S
S
Xie
Q
Q
Yu
F
F
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D015549:Basophil Degranulation Test; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D008168:Lung / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D017208:Rats, Wistar; D013189:SRS-A / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D018926:Anti-Allergic Agents; D013189:SRS-A; D062367:ortho-Aminobenzoates; C012293:tranilast