[Tumor genesis and prognostic factors in colorectal carcinoma with special consideration of tumor localization].
The rising incidence of colorectal carcinoma, particularly in the industrial nations of Europe and USA, directs the attention to the aetiological factors of these tumors: nutrition, the association with colorectal adenoma, familiarly genetic disorders as familiar adenomatous polyposis and hereditary non polyposis colorectal cancer. Some aspects of molecular biology are discussed. Furthermore, right and left part of the colon (divided by the Cannon-Boehm point) and the neoplasms of these sections of the colon are different in embryology, function and morphology. The cancers of the right colon develop without polypoid changes, those of the left part in majority via the adenoma-carcinoma sequence. It is possible to demonstrate differences between these two localizations in the DNA-content (diploid tumors on the right side), in the lost of allels (especially distal tumors), in proliferation activity (lower in right side tumors) and in the expression of oncofetal antigens. Besides, there are some histological differences between neoplasms of the right and left colon (production of mucin, "Crohns like lymphoid reaction" histological grading). In our own material of 262 patients with resected colon carcinoma we have investigated the distribution of carcinoma in the right and left colon, furthermore the T-classification, histological grading and the proportion of mucinous carcinoma in the different tumor localizations.
Emmrich
P
P
Institut für Pathologie, Universität Leipzig.
Hölzer
H
H
D003082:Colectomy; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis