title: [Anti glomerular basement membrane disease in a renal transplant patient with Alport syndrome].
abstract: We report a case of anti GBM disease that developed in the renal graft of a patient with Alport syndrome. After reaching abnormal values of creatinine, the patient presented with deteriorating renal function three months after a cadaver transplant and the biopsy showed crescent formation, and linear IF deposits. Circulating antibodies against alpha 5 chain of type IV collagen were found and plasmaphereses stabilized the condition for one year until a lung infection led to withdrawal of the immunosuppressive drugs and the patient returned to dialysis. We discuss the possible mechanisms underlying the specificity of the circulating antibodies in this case, which differs from the target characteristic of the idiopathic form of anti GBM disease, the alpha 3 (IV) chain.
authors.affiliation: Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Soler Pujol
authors.forename: R
authors.initials: R
authors.lastname: Iotti
authors.forename: M
authors.initials: M
authors.lastname: Dávalos Michel
authors.forename: A N
authors.initials: AN
authors.lastname: Turner
authors.forename: A R
authors.initials: AR
authors.lastname: Vilches
mesh_terms: D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009394:Nephritis, Hereditary / Q000601:surgery*; D010956:Plasmapheresis