Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits.
Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two-compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% +/- 1%, 12.3% +/- 0.7%, 118% +/- 1%, and 20.2% +/- 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels.
López-Cortés
L F
LF
Infectious Diseases Service, University of Seville, Seville, Spain. lflopez@cica.es
Ruiz-Valderas
R
R
Lucero-Muñoz
M J
MJ
Cordero
E
E
Pastor-Ramos
M T
MT
Marquez
J
J
D000818:Animals; D019540:Area Under Curve; D001921:Brain / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D017245:Foscarnet / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D011817:Rabbits; D012160:Retina / Q000378:metabolism*; D014822:Vitreous Body / Q000378:metabolism*
D017245:Foscarnet