title: Co-occurrence of mood and personality disorders: a report from the Collaborative Longitudinal Personality Disorders Study (CLPS).
abstract: The purpose of this study was to examine the relationship of subtypes and particular clinical features of mood disorders to co-occurrence with specific personality disorders. Five hundred and seventy-one subjects recruited for the Collaborative Longitudinal Personality Disorders Study (CLPS) were assessed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and the Diagnostic Interview for DSM-IV Personality Disorders (DIPD-IV). Percent co-occurrence rates for current and lifetime mood disorders with personality disorders were calculated. Logistic regression analyses examined the effects of clinical characteristics of depressive disorders (e.g., age at onset, recurrence, symptom severity, double depression, and atypical features) on personality disorder co-occurrence. In comparison with other DSM-IV personality disorders, avoidant, borderline, and dependent personality disorders (PDs) were most specifically associated with mood disorders, particularly depressive disorders. Severity and recurrence of major depressive disorder and comorbid dysthymic disorder predicted co-occurrence with borderline and to a lesser extent research criteria depressive personality disorders. The results are consistent with the view that a mood disorder with an insidious onset and recurrence, chronicity, and progression in severity leads to a personality disorder diagnosis in young adults.
authors.affiliation: Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Skodol
authors.forename: R L
authors.initials: RL
authors.lastname: Stout
authors.forename: T H
authors.initials: TH
authors.lastname: McGlashan
authors.forename: C M
authors.initials: CM
authors.lastname: Grilo
authors.forename: J G
authors.initials: JG
authors.lastname: Gunderson
authors.forename: M T
authors.initials: MT
authors.lastname: Shea
authors.forename: L C
authors.initials: LC
authors.lastname: Morey
authors.forename: M C
authors.initials: MC
authors.lastname: Zanarini
authors.forename: I R
authors.initials: IR
authors.lastname: Dyck
authors.forename: J M
authors.initials: JM
authors.lastname: Oldham
mesh_terms: D000293:Adolescent; D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications* / Q000175:diagnosis; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010554:Personality Disorders / Q000150:complications* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index