title: Simulated moving-bed chromatography and its application to chirotechnology.
abstract: The increased awareness of the differences in biological activity of the two enantiomers of a chiral drug has raised the demand for enantiomerically pure products, particularly in the pharmaceutical industry. Simulated moving-bed chromatography can be used for the separation of the two enantiomers of a chiral molecule, which is feasible at all production scales, from laboratory to pilot to production plant. The use of non-enantioselective synthesis of racemic mixtures and simulated moving-bed enantiomer separation might make the development process of a new chiral drug substantially shorter and cheaper.
authors.affiliation: Laboratorium für Technische Chemie, ETH Zürich, Universitätstr. 6, CH-8092 Zürich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Juza
authors.forename: M
authors.initials: M
authors.lastname: Mazzotti
authors.forename: M
authors.initials: M
authors.lastname: Morbidelli
mesh_terms: D002845:Chromatography; D013237:Stereoisomerism