title: Radiation and intra-arterial cisplatin: effects on arteries and free tissue transfer.
abstract: OBJECTIVE
  To determine the histopathologic effect of combined intra-arterial cisplatin administration and hyperfractionated external beam radiation treatment (HYPERRADPLAT) on potential recipient arteries in the neck and to analyze the efficacy of free tissue transfer (FTT) in patients undergoing HYPERRADPLAT.
  
  
  METHODS
  Cisplatin-perfused and nonperfused artery segments were harvested during planned interval neck dissection performed 6 to 10 weeks after HYPERRADPLAT. These segments were evaluated by light microscopy and transmission electron microscopy. All patients undergoing FTT after HYPERRADPLAT were reviewed retrospectively.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Eight patients undergoing HYPERRADPLAT for head and neck squamous cell carcinoma and planned interval neck dissection were prospectively studied. All patients had a perfused artery sampled, and 3 also had a nonperfused (control) artery sampled. Five patients undergoing FTT after HYPERRADPLAT were retrospectively analyzed for outcome of FTT.
  
  
  RESULTS
  No consistent histological or ultrastructural differences were detected between injected and noninjected arteries. Both demonstrated intimal thickening, collagen and elastin deposition in the intimal layer, and, occasionally, intimal smooth muscle proliferation. A smaller fraction of the injected and noninjected arteries demonstrated smooth muscle cell vacuolation, elastic fiber degeneration, and calcific deposits. Four of 5 FTTs in patients undergoing HYPERRADPLAT were successful.
  
  
  CONCLUSIONS
  The changes seen in the injected and noninjected arteries were characteristic of ionizing radiation. Arteries treated with HYPERRADPLAT had no observable difference from vessels treated with radiation alone. These vessels can be used with caution as recipient vessels for FTT. Further clinical experience is needed to establish the expected results of FTT using these arteries.
authors.affiliation: Division of Otolaryngology-Head and Neck Surgery, University of Kentucky Chandler Medical Center, Lexington 40536-0084, USA. jvale00@pop.uky.edu
authors.forename: J
authors.initials: J
authors.lastname: Valentino
authors.forename: L
authors.initials: L
authors.lastname: Weinstein
authors.forename: R
authors.initials: R
authors.lastname: Rosenblum
authors.forename: W
authors.initials: W
authors.lastname: Regine
authors.forename: M
authors.initials: M
authors.lastname: Weinstein
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001158:Arteries / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D019583:Dose Fractionation, Radiation; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D007261:Infusions, Intra-Arterial; D009333:Neck / Q000098:blood supply*; D011446:Prospective Studies; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000098:blood supply*
chemical_list: D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D002945:Cisplatin