Kaposi's sarcoma herpesvirus-associated Castleman's disease with POEMS syndrome.
The pathogenic link between POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes, and various other clinical signs) syndrome and Castleman's disease is unclear. Roles for M protein in POEMS syndrome and cytokines in systemic manifestations of multicentric Castleman's disease have been suggested. Recently, pathogenic roles of cytokines in POEMS syndrome and Kaposi's sarcoma-associated herpesvirus (KSHV) in Castleman's disease have been reported. We report on a patient with KSHV-associated Castleman's disease with POEMS syndrome, and suggest a possible role of KSHV in initiating and linking these two diseases.
Kim
D E
DE
Department of Neurology, College of Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-ku, Seoul 110-744, Korea.
Kim
H J
HJ
Kim
Y A
YA
Lee
K W
KW
D001706:Biopsy; D005871:Castleman Disease / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D016878:POEMS Syndrome / Q000473:pathology / Q000821:virology*
D004279:DNA, Viral