Antiphospholipid antibodies and in vitro fertilization success: a meta-analysis.
OBJECTIVE
To evaluate whether the presence of antiphospholipid antibodies among women undergoing IVF affects the likelihood of IVF success.


METHODS
A meta-analysis of seven eligible studies on antiphospholipid antibodies and IVF outcome.


METHODS
Odds ratios (ORs) and 95% confidence intervals (CIs) of an association between the presence of antiphospholipid antibodies and both clinical pregnancy and live birth from IVF.


RESULTS
There was no significant association between antiphospholipid abnormalities and either clinical pregnancy (OR 0.99; 95% CI 0.64-1.53) or live birth (OR 1.07; 95% CI 0.66-1.75) in IVF patients.


CONCLUSIONS
The measurement of antiphospholipid antibodies is not warranted in patients undergoing IVF.
Hornstein
M D
MD
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. mdhornstei@bics.bwh.harvard.edu
Davis
O K
OK
Massey
J B
JB
Paulson
R J
RJ
Collins
J A
JA
D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D010743:Phospholipids / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*; D018873:Pregnancy Rate
D001323:Autoantibodies; D010743:Phospholipids