title: Development of an antithrombogenic and antitraumatic blood pump: the Gyro C1E3.
abstract: The Gyro C1E3 is a centrifugal blood pump. Its antithrombogenic and antitraumatic blood features were demonstrated by prior studies. Based upon these studies, a mass production model of the C1E3 is becoming commercially available. Therefore, this feasibility study was conducted using the mass production models of the Gyro C1E3 for long-term cardiac assist in ex vivo animal experiments. Five healthy calves were used and 15 pump heads were applied for different time periods (Group 1, 30 days; Group 2, 14 days; Group 3, 10 and 7 days; Group 4, 4 days; and Group 5, 2 days). Activated clotting time (ACT) was kept at 200-250 sec. All five calves demonstrated neither abnormal signs nor abnormal blood examination data throughout the experiment. During necropsy, no thromboembolism was found in any downstream organs. Groups 1-4 showed thrombi inside the pump heads while two pumps in Group 5 had no thrombi formations. Bearing deformation or possible wear did not increase after 2 days of pumping. The C1E3 is capable of long-term assist circulation. However, after 2 days of pumping, careful observation is necessary since thrombi may occur inside the pump when ACT is controlled under 250 sec. During the weaning stage or low flow (under 2 L/min), over 250 sec of ACT is recommended to assure the safety of the patient.
authors.affiliation: Baylor College of Medicine, Department of Surgery, Houston TX 77030, USA.
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Nakata
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: A
authors.initials: A
authors.lastname: Fujisawa
authors.forename: K
authors.initials: K
authors.lastname: Makinouchi
authors.forename: M
authors.initials: M
authors.lastname: Yokokawa
authors.forename: S
authors.initials: S
authors.lastname: Murabayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000818:Animals; D002417:Cattle; D002498:Centrifugation; D006353:Heart-Assist Devices; D013927:Thrombosis / Q000517:prevention & control*