In vivo cytogenetic studies on blends of aspartame and acesulfame-K.
Aspartame and acesulfame-K, non-nutritive sweeteners, are permitted individually in diets and beverages. These sweeteners of different classes, used in combination, have been found to possess a synergistic sweetening effect. Whether they also have a synergistic genotoxic effect is unknown. Swiss Albino male mice were exposed to blends of aspartame (3.5, 35, 350mg/kg body weight) and acesulfame-K (1.5, 15 and 150mg/kg body weight) by gavage. Bone marrow cells isolated from femora were analysed for chromosome aberrations. Statistical analysis of the results show that aspartame in combination with acesulfame-K is not significantly genotoxic.
Mukhopadhyay
M
M
Centre for Advanced Studies on Cell and Chromosome Research, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, Calcutta 700 019, India.
Mukherjee
A
A
Chakrabarti
J
J
D000818:Animals; D001218:Aspartame / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D008297:Male; D051379:Mice; D012449:Safety; D013843:Thiazines / Q000633:toxicity*
D013843:Thiazines; C006362:acetosulfame; D001218:Aspartame