Tardive dyskinesia: possible involvement of free radicals and treatment with vitamin E.
A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.
Elkashef
A M
AM
Medications Development Division, National Institute on Drug Abuse, Bethesda, MD 20892-9551, USA. ae8a@nih.gov
Wyatt
R J
RJ
D000975:Antioxidants / Q000627:therapeutic use*; D004409:Dyskinesia, Drug-Induced / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D009410:Nerve Degeneration / Q000150:complications / Q000473:pathology; D014810:Vitamin E / Q000627:therapeutic use*
D000975:Antioxidants; D005609:Free Radicals; D014810:Vitamin E