title: Maternal neonatal outcome in quadruplet and quintuplet versus triplet gestations.
abstract: OBJECTIVE
  Examination and comparison of the natural histories of triplet versus quadruplet and quintuplet gestations.
  
  
  METHODS
  A retrospective study of sixty-four multifetal pregnancies (fifty-two sets of triplets, nine sets of quadruplets and three sets of quintuplets) cared for during past 12 years in our department. Quintuplets and quadruplets were compared with triplet pregnancies according to gestational age, birthweight, pregnancy complications and perinatal outcome. Student's t-test, Fisher exact test and chi2 test were used for statistical analysis, considering P value of <0.05 as statistically significant.
  
  
  RESULTS
  Although mean gestational age at delivery between triplets and higher order gestations was not significantly different, birthweight of quadruplets and quintuplets was significantly lower. Pregnancy complications, including intrauterine growth retardation, were equally distributed between the groups. Early neonatal and perinatal mortality were significantly higher in quadruplets and quintuplets than in triplets. Surprisingly, survival of growth retarded fetuses was better than survival of their eutrophic counterparts. The spontaneous loss rate was 11.5% for entire triplet gestation and 16.7% for quadru- and quintuplet pregnancies.
  
  
  CONCLUSIONS
  As the spontaneous loss rate of triplets and higher order pregnancies observed in our study is quite similar to pregnancy loss rate caused by multifetal pregnancy reduction, conservative management of multifetal pregnancies in specialised tertiary centers seems to be a prudent solution.
authors.affiliation: Department of Perinatal Medicine, University Medical School, Zagreb, Croatia. ivan.kuvacic@zg.tel.hr
authors.forename: S
authors.initials: S
authors.lastname: Skrablin
authors.forename: I
authors.initials: I
authors.lastname: Kuvacić
authors.forename: D
authors.initials: D
authors.lastname: Pavicić
authors.forename: D
authors.initials: D
authors.lastname: Kalafatić
authors.forename: T
authors.initials: T
authors.lastname: Goluza
mesh_terms: D001724:Birth Weight; D002584:Cervix Uteri / Q000601:surgery; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D007234:Infant, Premature; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D012189:Retrospective Studies; D015145:Tocolysis; D014310:Triplets