dl-3-n-butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats.
OBJECTIVE
To investigate the effect of dl-3-n-butylphthalide (dl-NBP) on experimental subarachnoid hemorrhage (SAH) in rats.


METHODS
SAH was induced by injection of autologous artery blood 0.35 mL into lateral ventricle. Regional cerebral blood flow (rCBF) in caudate nucleus was determined by hydrogen clearance method.


RESULTS
A rapid and marked decrease in rCBF in caudate nucleus was observed 15 min after SAH and the rCBF remained at low level (about 50% pre-SAH value) within 180 min. dl-NBP (50, 100 mg.kg-1, i.g.) increased rCBF 30-180 min after the onset of SAH without significant effect on mean artery blood pressure. dl-NBP 100 mg.kg-1 increased rCBF in caudate nucleus by 26% at 15 min and by 36% at 180 min respectively after SAH. d-NBP but not l-NBP (10 mg.kg-1, i.p.) increased rCBF.


CONCLUSIONS
dl-NBP improves rCBF in caudate nucleus of rats subjected to SAH.
Chong
Z Z
ZZ
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, China.
Feng
Y P
YP
D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002421:Caudate Nucleus / Q000098:blood supply*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology*
D001572:Benzofurans; D018696:Neuroprotective Agents; C027125:3-n-butylphthalide