title: Topical therapy for acne.
abstract: Acne is a common problem in adolescents and young adults. The disorder is caused by abnormal desquamation of follicular epithelium that results in obstruction of the pilosebaceous canal. This obstruction leads to the formation of comedones, which can become inflamed because of overgrowth of Propionibacterium acnes. Topical retinoids such as tretinoin or adapalene are effective in many patients with comedonal acne. Patients with inflammatory lesions benefit from treatment with benzoyl peroxide, azelaic acid or topical antibiotics. Frequently, the use of comedonal and antibacterial agents is required.
authors.affiliation: Abington Memorial Hospital, Pennsylvania, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Russell
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000503:physiopathology; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001585:Benzoyl Peroxide / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000008:administration & dosage; D003998:Dicarboxylic Acids / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage; D010353:Patient Education as Topic; D014677:Pharmaceutical Vehicles; D012176:Retinoids / Q000008:administration & dosage; D020156:Salicylic Acid / Q000008:administration & dosage; D013409:Sulfacetamide / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D003879:Dermatologic Agents; D003998:Dicarboxylic Acids; D007641:Keratolytic Agents; D014677:Pharmaceutical Vehicles; D012176:Retinoids; D013409:Sulfacetamide; C010038:azelaic acid; D020156:Salicylic Acid; D001585:Benzoyl Peroxide