title: Base-catalyzed epimerization of the butenolide in annonaceous acetogenins.
abstract: The elusive epimerization process in the chiral butenolide moiety of Annonaceous acetogenins was examined under several sets of conditions commonly used for elimination leading to the alpha, beta-unsaturated lactone and the results provide practical guidance in choosing elimination conditions.
authors.affiliation: State Key Laboratory of Bio-organic and Natural Products Chemistry, and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: Y L
authors.initials: YL
authors.lastname: Wu
authors.forename: L J
authors.initials: LJ
authors.lastname: Xia
authors.forename: M H
authors.initials: MH
authors.lastname: Tang
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives; D002384:Catalysis; D002942:Circular Dichroism; D005663:Furans / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005663:Furans; D007783:Lactones; C112079:isomurisolenin; C004511:butenolide; D015107:4-Butyrolactone