title: Solution-phase combinatorial synthesis and evaluation of piperazine-2,5-dione derivatives.
abstract: An efficient one-pot synthesis of a 61-membered combinatorial chemistry library of piperazine-2,5-diones was accomplished. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.
authors.affiliation: School of Science, Griffith University, Brisbane, Australia.
authors.forename: W A
authors.initials: WA
authors.lastname: Loughlin
authors.forename: R L
authors.initials: RL
authors.lastname: Marshall
authors.forename: A
authors.initials: A
authors.lastname: Carreiro
authors.forename: K E
authors.initials: KE
authors.lastname: Elson
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000633:toxicity; D020650:Combinatorial Chemistry Techniques; D033364:Decapoda / Q000187:drug effects; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010879:Piperazines