The c-myc locus is a common integration site in type B retrovirus-induced T-cell lymphomas.
Type B leukemogenic virus (TBLV) induces rapidly appearing T-cell leukemias. TBLV insertions near the c-myc gene were detectable in 2 of 30 tumors tested, whereas 80% of the tumors showed c-myc overexpression. TBLV insertions on chromosome 15 (including a newly identified locus, Pad7) may cause c-myc overexpression by cis-acting effects at a distance.
Rajan
L
L
Section of Molecular Genetics and Microbiology and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78705, USA.
Broussard
D
D
Lozano
M
M
Lee
C G
CG
Kozak
C A
CA
Dudley
J P
JP
D000818:Animals; D030121:Betaretrovirus / Q000235:genetics*; D002874:Chromosome Mapping; D016259:Genes, myc / Q000235:genetics*; D016399:Lymphoma, T-Cell / Q000235:genetics* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016662:Virus Integration / Q000235:genetics