Detrimental effects of oestradiol on cysteamine-induced gastroduodenal ulceration in the female rat.
The actions of the female sex steroid, oestradiol on cysteamine-induced mucosal ulceration has been evaluated in female Wistar rats. Administration of cysteamine (400 mg x kg(-1), s.c.) provoked macroscopic gastroduodenal mucosal injury (assessed planimetrically) and an increase in microvascular permeability (assessed by the extravasation of radiolabeled albumin) in the stomach and duodenum, determined 24 h later. Ovariectomy (2 weeks before cysteamine) reduced gastroduodenal macroscopic injury, and albumin extravasation following cysteamine challenge. Administration of oestradiol (1-5 mg x kg(-1), as an i.m. depot 1 week before cysteamine) dose-dependently augmented gastric and duodenal macroscopic mucosal lesions and microvascular permeability provoked by cysteamine. These findings indicate that oestradiol can exacerbate gastroduodenal ulceration and microvascular injury.
Szepes
Z
Z
First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Morschl
E
E
Kiss
J
J
Pávó
I
I
Whittle
B J
BJ
Varga
C
C
László
F A
FA
László
F
F
D000818:Animals; D003543:Cysteamine; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology; D010052:Ovariectomy; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
D004958:Estradiol; D003543:Cysteamine