title: [Some historic milestones of clinical haematology].
abstract: Microscopy, cell staining methods and tests for characterization of coagulation factor deficiencies are the landmarks of hematology at the beginning. Direct access to bone marrow, automatization, development of in vitro culture systems, monoclonal antibodies, biochemistry of proteins and nucleic acids were used to build today conception of the blood. Definitions of stem cells, growth factors, chromosomal translocations in leukemias and coagulation cascade represent the various aspects of the complex scientific object that the blood became.
authors.affiliation: Laboratoire central d'hématologie, Hôpital Necker, 149, rue de Sèvres, 75743 Paris cedex 15.
authors.forename: P
authors.initials: P
authors.lastname: Triadou
mesh_terms: D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000175:diagnosis; D002624:Chemistry, Clinical / Q000379:methods*; D006405:Hematology / Q000379:methods*; D006801:Humans; D008853:Microscopy