title: Characterization of a new ATP-binding cassette transporter in Trypanosoma cruzi associated to a L1Tc retrotransposon.
abstract: We have characterized the tcpgp1-like gene of Trypanosoma cruzi, a new ATP-binding cassette (ABC) transporter. tcpgp1 codes for a 1035 amino acid protein with a considerable homology to LtpgpA of Leishmania. Tcpgp1 lacks the conserved sequences corresponding to the second nucleotide-binding domain of other ABC transporters due to the insertion of the L1Tc non-LTR retrotransposon.
authors.affiliation: Departamento de Bioquímica y Farmacología Molecular, Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Cientficas, Granada, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Torres
authors.forename: L
authors.initials: L
authors.lastname: Barreiro
authors.forename: B
authors.initials: B
authors.lastname: Dallagiovanna
authors.forename: F
authors.initials: F
authors.lastname: Gamarro
authors.forename: S
authors.initials: S
authors.lastname: Castanys
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D006023:Glycoproteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D015800:Protozoan Proteins; D018626:Retroelements; D014349:Trypanosoma cruzi / Q000235:genetics*
chemical_list: D018528:ATP-Binding Cassette Transporters; D006023:Glycoproteins; D015800:Protozoan Proteins; D018626:Retroelements; C404509:Tcpgp1 protein, Trypanosoma cruzi