Diagnosis of malignant mesothelioma by fine needle aspiration of a cervical lymph node. A case report.
BACKGROUND
Clinically documented distant metastases are rare in mesothelioma and tend to occur late in the course of the disease, well after the diagnosis has been made. In this instance, diagnosis was not made until a metastatic deposit was identified microscopically in the enlarged lymph node.


METHODS
A 65-year-old male with no definite history of occupational asbestos exposure presented with chest pain, pleural effusion and supraclavicular lymphadenopathy. Cytologic examination of material obtained by fine needle aspiration from his cervical lymph node revealed malignant mesothelioma. This was confirmed on histology.


CONCLUSIONS
This was a particularly rare presentation and, as far as we are aware, was the first case in which mesothelioma was diagnosed by fine needle aspiration of a cervical lymph node. It serves to remind the pathologist that when confronted with a lymph node involved by tumor, the possibility of mesothelioma should be included in the differential diagnosis. The case also demonstrates the usefulness of fine needle aspiration in the diagnosis of metastatic tumor.
Ansari
N A
NA
Department of Histopathology, St. Thomas' Hospital, London, U.K.
Derias
N W
NW
D000230:Adenocarcinoma / Q000737:chemistry / Q000175:diagnosis; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008654:Mesothelioma / Q000737:chemistry / Q000175:diagnosis* / Q000556:secondary; D010997:Pleural Neoplasms / Q000737:chemistry / Q000175:diagnosis*
D014408:Biomarkers, Tumor