title: Reduction of corpus callosum growth after severe traumatic brain injury in children.
abstract: OBJECTIVE
  To study effects of closed head injury (CHI) severity on development of corpus callosum (CC) in children, using MRI.
  
  
  BACKGROUND
  Vulnerability of CC to diffuse axonal injury has been shown in adults and children by neuropathologic and MRI studies. Given continued development of CC through the second decade, serial MRI could characterize effects of CHI on CC growth in children.
  
  
  METHODS
  MRI performed at 3 and 36 months after severe (mean age = 10.3 years, n = 25) and mild to moderate (mean age = 9.7 years, n = 28) CHI. Mild to moderate and severe CHI groups did not differ in demographic features. Morphometry of T1-weighted midsagittal CC by two operators with satisfactory interrater reliability yielded uncorrected and corrected CC volume.
  
  
  RESULTS
  An interaction of occasion with CHI severity was present as CC area decreased from 3 to 36 months in severely injured children and increased in the mild to moderate CHI group. Uncorrected CC area was correlated with acute CHI severity and functional outcome at 36 months postinjury.
  
  
  CONCLUSIONS
  Morphometric measurement of CC area provides a useful index of diffuse injury, which is related to functional outcome of CHI in children.
authors.affiliation: Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: H S
authors.initials: HS
authors.lastname: Levin
authors.forename: D A
authors.initials: DA
authors.lastname: Benavidez
authors.forename: K
authors.initials: K
authors.lastname: Verger-Maestre
authors.forename: N
authors.initials: N
authors.lastname: Perachio
authors.forename: J
authors.initials: J
authors.lastname: Song
authors.forename: D B
authors.initials: DB
authors.lastname: Mendelsohn
authors.forename: J M
authors.initials: JM
authors.lastname: Fletcher
mesh_terms: D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male