title: Differential expression of cadherin adhesion receptors in neural retina of the postnatal mouse.
abstract: OBJECTIVE
  To determine the expression pattern of multiple subtypes of cadherin adhesion receptor in postnatal mouse neural retina.
  
  
  METHODS
  The expression of N-cadherin, R-cadherin, cadherin-6, cadherin-8, and cadherin-11 in retinas at postnatal days 0 to 42 was analyzed by in situ hybridization of mRNA as well as by immunohistochemistry.
  
  
  RESULTS
  Each cadherin was expressed by different cell populations of the retina, and the following expression patterns were established by postnatal day 14: in the ganglion cell layer, all these molecules were expressed, but each occurred only in a subset of the cells. Likewise, in the inner nuclear layer, R-cadherin and cadherin-6 and -8 were expressed by a restricted population of amacrine cells, and cadherin-8 also by a subpopulation of bipolar cells. All horizontal cells expressed R-cadherin, and Muller cells expressed N-cadherin and cadherin-11. Proteins of R-cadherin and cadherin-6 were concentrated in neuropil layers.
  
  
  CONCLUSIONS
  The pattern of differential expression of the five cadherins supports the idea that these molecules may play a role in selective cell interactions within the heterogeneous cell pool of the neural retina.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shogoin, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Honjo
authors.forename: H
authors.initials: H
authors.lastname: Tanihara
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Takeichi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal; D015820:Cadherins / Q000235:genetics / Q000378:metabolism*; D019084:Fluorescent Antibody Technique, Indirect; D015151:Immunoblotting; D017403:In Situ Hybridization; D016023:Integrins / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D012333:RNA, Messenger / Q000378:metabolism; D012160:Retina / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D015820:Cadherins; D016023:Integrins; D012333:RNA, Messenger