title: MSY2: a slowly evolving minisatellite on the human Y chromosome which provides a useful polymorphic marker in Chinese populations.
abstract: We present the second human Y-specific minisatellite, MSY2 (DYS440). It consists of three or four copies of a 99-110bp repeat unit and is located about 1kb upstream of the DBY gene. The most common allele contains four units, but a three-unit allele has arisen on at least four occasions; in chimpanzees and orangutans, MSY2 contains only two units. It is therefore evolving slowly and provides a particularly useful polymorphic marker for Chinese populations.
authors.affiliation: Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.
authors.forename: W
authors.initials: W
authors.lastname: Bao
authors.forename: S
authors.initials: S
authors.lastname: Zhu
authors.forename: A
authors.initials: A
authors.lastname: Pandya
authors.forename: T
authors.initials: T
authors.lastname: Zerjal
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: Q
authors.initials: Q
authors.lastname: Shu
authors.forename: R
authors.initials: R
authors.lastname: Du
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: C
authors.initials: C
authors.lastname: Tyler-Smith
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002681:China; D004247:DNA / Q000737:chemistry / Q000235:genetics; D015342:DNA Probes; D005260:Female; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics; D011110:Polymorphism, Genetic; D011148:Pongo pygmaeus / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014998:Y Chromosome / Q000235:genetics*
chemical_list: D015342:DNA Probes; D005819:Genetic Markers; D004247:DNA