[Changes of carbohydrate metabolism in normal pregnancy and its relationship with placental lactogen concentrations].
OBJECTIVE
To observe the changes of glucose metabolism and its relationship with human placental lactogen (HPL) in normal pregnant women.


METHODS
94 normal pregnant women had their serum HPL concentration tested and had undergone a 75 g oral glucose tolerance tests (OGTT). Both serum insulin and glucose levels at different time intervals were determined, and the areas under curve (IAUC, GAUC) were caculated, also insulin resistance (IAI) was evaluated.


RESULTS
GAUC, IAUC, IAI and HPL are all significantly increased with advance of gestation (P < 0.05). Multiple correlation coefficient study demonstrated that HPL is significantly positively correlated with GAUC, IAUC and IAI(P < 0.001). But when IAUC and IAI were controlled, the relationship between HPL and GAUC was not found.


CONCLUSIONS
There are hyperinsulinemia and insulin resistance during pregnancy, and they are related to HPL. HPL is one of the factors that contributing to carbohydrate metabolism changes during pregnancy.
Cao
X
X
First Affiliate Hospital of Sun Yat-sen Univeristy of Medical Sciences, Guangzhou 510080.
Qin
W
W
He
Z
Z
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy / Q000378:metabolism*
D001786:Blood Glucose; D007328:Insulin; D010928:Placental Lactogen