title: [Partial non-convulsive status epilepsy in multiple sclerosis].
abstract: This report describes the observations of two patients with a several years' history of multiple sclerosis who presented sudden neurologic impairment. The symptomatology was suggestive of a non-convulsive partial status epilepsy. The clinical presentation was a paroxysmal dysphasic phenomenon in the first case without any consciousness impairment, associated with slight right hemiparesis. Electroencephalographic investigations revealed asymmetrical patterns, left-sided slow waves and periodic lateralized epileptiform discharges (PLEDs). Antiepileptic treatments were partially effective and intravenous steroids were needed for complete recovery. For the second patient, clinical presentation was acute psychiatric symptoms with disorientation, alternating manic symptomatology and mutism. Electroencephalography showed left fronto-central rhythmic continuous slow wave and spike wave activity. Intravenous antiepileptic treatment quickly improved the symptomatology. These observations draw attention to the fact that an epileptic cause should not be ruled out when a patient with multiple sclerosis presents sudden neurologic or psychiatric impairment. An early diagnosis allows immediate antiepileptic treatment. Intravenous steroids can be added to stop seizures.
authors.affiliation: Service de neurologie B, hôpital neurologique, Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Maingueneau
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: J
authors.initials: J
authors.lastname: Isnard
authors.forename: C
authors.initials: C
authors.lastname: Tommasi-Davenas
authors.forename: L
authors.initials: L
authors.lastname: Derex
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy; D013226:Status Epilepticus / Q000175:diagnosis / Q000209:etiology*; D013256:Steroids
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids