title: [Changes of plasma endothelin-1 in patients with congestive heart failure and the influence of metoprolol].
abstract: To investigate the alterations of plasma endothelin-1(ET-1) in patients with congestive heart failure(CHF) and the effects of metoprolol on it, plasma ET-1 and norepinephrine(NE) were measured in 43 patients using radioimmunoassay and high-performance liquid chromatography methods. Twenty-four patients were treated with metoprolol plus the routine therapy while the others were received the routine therapy only. The findings were that levels of plasma ET-1 and NE increased before the treatment, and decreased after the treatment with metoprolol for 1 month. There was no alteration of plasma ET-1 or NE in the control group.
authors.affiliation: Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Zhou
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood
chemical_list: D000319:Adrenergic beta-Antagonists; D019332:Endothelin-1; D008790:Metoprolol; D009638:Norepinephrine