Strategies for analyzing genotype-phenotype relationships in asthma.
Asthma is a genetically complex disease with a multifaceted phenotype. Different approaches including population-based and family-based methods for evaluating genotype-phenotype relationships in asthma are discussed as well as the problems that may obscure these determinations. Examples of similar efforts in cystic fibrosis and breast cancer are considered in addition to interaction between causative genes and etiologically relevant environmental exposure.
Wiesch
D G
DG
Center for the Genetics of Asthma and Complex Diseases, University of Maryland, Baltimore 21201, USA.
Meyers
D A
DA
D001249:Asthma / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics; D003550:Cystic Fibrosis / Q000235:genetics; D005260:Female; D005821:Genetic Techniques; D005838:Genotype; D006801:Humans; D010641:Phenotype