title: Out of Eden: stem cells and their niches.
abstract: Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.
authors.affiliation: Keratinocyte Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
authors.forename: F M
authors.initials: FM
authors.lastname: Watt
authors.forename: B L
authors.initials: BL
authors.lastname: Hogan
mesh_terms: D000818:Animals; D002450:Cell Communication; D002454:Cell Differentiation; D002455:Cell Division; D019070:Cell Lineage; D005109:Extracellular Matrix / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D016023:Integrins / Q000502:physiology; D011506:Proteins / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
chemical_list: D016023:Integrins; D011506:Proteins; D014157:Transcription Factors