title: Research toward safer resection of the cirrhotic liver.
abstract: Despite recent advances in hepatic surgery, resection of the cirrhotic liver continues to be fraught with high morbidity and mortality rates. As a result, for many patients requiring resection of HCC the postoperative course is complicated and the probability of cure is diminished by coexisting cirrhosis. In this review, we discuss the characteristics of the cirrhotic liver which make it poorly tolerant of resection and the most common complications that follow such surgery. The main purpose of this paper is to review recent attempts to identify interventions that might be beneficial to cirrhotic patients undergoing resection. These interventions include assessment of liver reserve, advances in surgical technique, and improvement in liver function and regeneration.
authors.affiliation: Department of Surgery, University of Manitoba, Winnipeg, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Moser
authors.forename: N M
authors.initials: NM
authors.lastname: Kneteman
authors.forename: G Y
authors.initials: GY
authors.lastname: Minuk
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000601:surgery*; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery*; D008115:Liver Regeneration; D008875:Middle Aged; D011183:Postoperative Complications