Biology of renal aging in humans.
Advancing age is usually accompanied by a decline in glomerular filtration rate and an increased incidence of certain renal and electrolyte disorders. These include an increased susceptibility to acute renal failure, hypo- and hypernatremia, hyperkalemia, and hypertension. This report discusses anatomic and physiological observations related to the aged human kidney and explores the various theories and postulated mechanisms underlying these changes.
Clark
B
B
Allegheny General Hospital, Pittsburgh, PA 15212, USA.
D000375:Aging / Q000502:physiology*; D001834:Body Water / Q000378:metabolism; D005355:Fibrosis; D005923:Glomerulosclerosis, Focal Segmental / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000502:physiology* / Q000503:physiopathology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism
D012964:Sodium; D011188:Potassium