title: Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock.
abstract: OBJECTIVE
  To measure arterial lactate/pyruvate (L/P) and arterial ketone body ratios as reflection of cytoplasmic and mitochondrial redox state at different stages of catecholamine-treated septic shock and compare them with normal and pathologic values obtained in patients in shock who have decreased oxygen transport (cardiogenic shock), and to assess the relationship between the time course of lactate, L/P ratio, and mortality in septic shock.
  
  
  METHODS
  Prospective, observational human study.
  
  
  METHODS
  A university intensive care unit.
  
  
  METHODS
  Sixty consecutive adult patients who developed septic shock and lactic acidosis requiring the administration of vasopressors. Twenty patients in the intensive care unit without shock, sepsis, and hypoxia and with normal lactate values and 10 patients with cardiogenic shock were also studied.
  
  
  METHODS
  Hemodynamic measurements, arterial and mixed venous blood gases, arterial lactate and pyruvate concentrations, and arterial ketone body ratio were measured within 4 hrs after the introduction of catecholamine and 24 hrs later.
  
  
  RESULTS
  Fifteen patients (25%) died within the first 24 hrs of septic shock, and these early fatalities had a higher blood lactate (12.2+/-3 versus 4.6+/-1.3 mmol/L; p<.01) concentration and a higher L/P ratio (37+/-4 versus 20+/-1; p<.01) than those who died later. No difference was found for arterial ketone body ratio (0.41+/-0.1 versus 0.50+/-0.06). Forty-five patients survived >24 hrs including 25 survivors and 20 nonsurvivors. Although there was no difference between survivors and nonsurvivors in initial lactate concentration (4.1+/-0.4 and 4.6+/-0.3, respectively), L/P ratio (19+/-1 and 20+/-1, respectively), and arterial ketone body ratio (0.5+/-0.06 and 0.52+/-0.07, respectively), blood lactate and L/P ratio significantly decreased during the first 24 hrs in the survivors (2.8+/-0.4 and 14+/-1, respectively; p<.05). and were stable in the nonsurvivors (4+/-0.3 and 22+/-1, respectively) Although returning to normal values after 24 hrs in survivors and nonsurvivors, arterial ketone body ratio was higher in survivors (1.72+/-0.17 versus 1.09+/-0.15; p<.05). Lactate and L/P ratio were closely correlated (r2 = .8, p<.0001). In the cardiogenic shock group, lactate concentration was 4+/-1 mmol/L, L/P ratio was 40+/-6, and arterial ketone body ratio was 0.2+/-0.05. The mortality rate was 60%.
  
  
  CONCLUSIONS
  The main result of the present study is that hemodynamically unstable patients with sepsis needing catecholamine therapy had a lactic acidosis with an elevated L/P ratio and a decreased arterial ketone body ratio, suggesting a decrease in cytoplasmic and mitochondrial redox state. The duration of lactic acidosis is associated with the development of multiple organ failure and death.
authors.affiliation: Polyvalent Intensive Care Unit, Central Hospital, Nancy Cedex, France.
authors.forename: B
authors.initials: B
authors.lastname: Levy
authors.forename: L O
authors.initials: LO
authors.lastname: Sadoune
authors.forename: A M
authors.initials: AM
authors.lastname: Gelot
authors.forename: P E
authors.initials: PE
authors.lastname: Bollaert
authors.forename: P
authors.initials: P
authors.lastname: Nabet
authors.forename: A
authors.initials: A
authors.lastname: Larcan
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002395:Catecholamines / Q000627:therapeutic use; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007657:Ketone Bodies / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019289:Pyruvic Acid / Q000097:blood; D012770:Shock, Cardiogenic / Q000097:blood*; D012772:Shock, Septic / Q000097:blood* / Q000188:drug therapy; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D002395:Catecholamines; D007657:Ketone Bodies; D014662:Vasoconstrictor Agents; D019344:Lactic Acid; D019289:Pyruvic Acid