[Plasma levels of lipids, lipoproteins and apolipoproteins affected by endogenous testosterone].
Plasma testosterone(T), estrodiol(E), total cholesterol(TC), triglyceride(TG), high density lipoprotein-cholesterol(HDL-C), HDL2-C, HDL3-C, lipoprotein(a)[Lp(a)], apolipoprotein(Apo) AI and B100 were determined in 201 subjects, among them 102 patients with coronary heart disease(CHD) and 99 healthy subjects. It was observed that plasma T level was correlated negatively with TG(r = -0.47, P < 0.01) and Lp(a) (r = -0.163, P < 0.05), and positively with HDL3-C(r = 0.328, P < 0.01) and Lp(a)(r = -0.163, P < 0.05), and positively with HDL-3(r = 0.328, P < 0.01) and HDL3-C(r = 0.328, P < 0.01). Meanwhile, plasma levels of TG (1.47 +/- 1.16 mmol.L-1) and Lp(a)(25 +/- 17.8 g.L-1) were significantly higher in the subjects with low plasma T level (< 270 ng.ml-1) than those in the subjects with normal plasma T level (1.10 +/- 0.74 mmol.L-1 and 17 +/- 15.9 g.L-1, respectively), while plasma levels of HDL-C (1.31 +/- 0.30 mmol.L-1) and HDL3-C(0.88 +/- 0.22 mmol.L-1) were significantly lower in the former than in the latter (1.44 +/- 0.33 mmol.L-1 and 1.02 +/- 0.26 mmol.L-1, respectively). The results support that low plasma T level may be a risk factor for coronary heart disease, which may relate to the changes of plasma lipoproteins.
Zhao
S
S
Department of Cardiovascular Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha.
Li
X
X
Wang
Z
Z
D000368:Aged; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D008076:Cholesterol, HDL; D017270:Lipoprotein(a); D014280:Triglycerides; D013739:Testosterone; D002784:Cholesterol