An EEG should not be obtained routinely after first unprovoked seizure in childhood.
OBJECTIVE
To quantify and analyze the value of expected information from an EEG after first unprovoked seizure in childhood.


BACKGROUND
An EEG is often recommended as part of the standard diagnostic evaluation after first seizure.


METHODS
A MEDLINE search from 1980 to 1998 was performed. From eligible studies, data on EEG results and seizure recurrence risk in children were abstracted, and sensitivity, specificity, and positive and negative predictive values of EEG in predicting recurrence were calculated. Linear information theory was used to quantify and compare the expected information from the EEG in all studies. Standard test-treat decision analysis with a treatment threshold at 80% recurrence risk was used to determine the range of pretest recurrence probabilities over which testing affects treatment decisions.


RESULTS
Four studies involving 831 children were eligible for analysis. At best, the EEG had a sensitivity of 61%, a specificity of 71%, and an expected information of 0.16 out of a possible 0.50. The pretest probability of recurrence was less than the lower limit of the range for rational testing in all studies.


CONCLUSIONS
In this analysis, the quantity of expected information from the EEG was too low to affect treatment recommendations in most patients. EEG should be ordered selectively, not routinely, after first unprovoked seizure in childhood.
Gilbert
D L
DL
Department of Neurology, Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
Buncher
C R
CR
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D006801:Humans; D007223:Infant; D011237:Predictive Value of Tests; D012008:Recurrence; D012640:Seizures / Q000503:physiopathology*; D012680:Sensitivity and Specificity