title: Ovarian stimulation and endometrial receptivity.
abstract: Endometrial receptivity is a limiting step in the success of in-vitro fertilization (IVF). To investigate this issue, we selected a specific population of high responder patients in whom implantation was impaired, even when good quality embryos were transferred. We present a series of studies showing that high oestradiol concentrations on the day of human chorionic gonadotrophin (HCG) administration are detrimental to uterine receptivity. In addition, we suggest clinical strategies to improve endometrial receptivity in high responder patients using a step-down regimen.
authors.affiliation: Instituto Valenciano de Infertilidad, Valencia, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Valbuena
authors.forename: M
authors.initials: M
authors.lastname: Jasper
authors.forename: J
authors.initials: J
authors.lastname: Remohí
authors.forename: A
authors.initials: A
authors.lastname: Pellicer
authors.forename: C
authors.initials: C
authors.lastname: Simón
mesh_terms: D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D010064:Embryo Implantation; D004717:Endometrium / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D012099:Reproductive Techniques
chemical_list: D006063:Chorionic Gonadotropin; D004958:Estradiol