[Efficacy of emoxipin in treatment of arterial hypertension in the Far North].
A total of 95 hypertensive men working in duty regimen in the extreme North were examined. The men were found to have lipid metabolism disorders, activation of lipid peroxidation, decreased antioxidant defense in red cell membranes in all the examinees vs control hypertensive men living in moderate climatic zone. Effect of 2-week monotherapy with emoxipin was studied in 29 males with mild arterial hypertension free of obesity and coexisting diseases. Placebo was given to 10 patients. Emoxipin had an antihypertensive and antioxidant effects, improved structural-functional condition of erythrocytes in hypertensive patients.
Vershinina
A M
AM
Gapon
L I
LI
Shurkevich
N P
NP
Bazhukhina
I F
IF
Petelina
T I
TI
Savel'eva
N Iu
NIu
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001110:Arctic Regions; D001794:Blood Pressure / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D003081:Cold Climate; D004781:Environmental Exposure; D004910:Erythrocyte Membrane / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010847:Picolines / Q000627:therapeutic use*; D012800:Siberia; D016896:Treatment Outcome
D000975:Antioxidants; D010847:Picolines; C009820:6-methyl-2-ethyl-3-hydroxypyridine