title: The effect of intravesical mitomycin C on the recurrence of superficial (Ta-T1) bladder cancer. A Hungarian Multicenter Study.
abstract: We evaluated the prophylactic efficacy of instillations of intravesical mitomycin C in 57 patients with primary superficial bladder cancer in a multicenter clinical trial. After complete transurethral resection of Ta-T1 G1-G2 transitional cell bladder carcinomas, patients were treated with mitomycin 40 mg/50 ml saline of 15 instillations for 12 months. Most of the complications were mild and transient but two patients dropped out of the trial because of moderate side effects. Fifty-one patients were evaluable. We observed tumour recurrences in six patients (11.8%) during a median follow-up of 44.5 months. The recurrences were treated by transurethral resection. There was no muscle invasive progression in the recurrences. Our investigations confirm the effectiveness of mitomycin C in the treatment of patients with superficial bladder cancer.
authors.forename: J
authors.initials: J
authors.lastname: Kondás
authors.forename: L
authors.initials: L
authors.lastname: Kiss
authors.forename: A
authors.initials: A
authors.lastname: Határ
authors.forename: A
authors.initials: A
authors.lastname: Kiss
authors.forename: T
authors.initials: T
authors.lastname: Lukács
authors.forename: P
authors.initials: P
authors.lastname: Szeldeli
authors.forename: F
authors.initials: F
authors.lastname: Törzsök
authors.forename: I
authors.initials: I
authors.lastname: Bodrogi
mesh_terms: D000283:Administration, Intravesical; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D006814:Hungary; D016685:Mitomycin / Q000008:administration & dosage*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000517:prevention & control* / Q000601:surgery; D009367:Neoplasm Staging; D012086:Reoperation; D012189:Retrospective Studies; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin