title: Toxicology and evaluation of microcystins.
abstract: This paper reviews the toxicity and tumor-promoting properties of microcystins. Methods for screening and/or identification of microcystins in environmental samples are discussed and compared. Specific emphasis is placed on newly developed extraction/detection methods, e.g., solid phase microextraction (SPME) technique, and capillary electrophoresis coupled with laser-induced fluorescence detection. The results of a kinetic analysis of the effects of microcystins on phosphorylase-a binding to phosphatase-2A using a surface plasmon resonance biosensor are also presented.
authors.affiliation: Centre for Coastal Pollution and Conservation, Department of Biology and Chemistry, City University of Hong Kong, Kowloon.
authors.forename: P K
authors.initials: PK
authors.lastname: Lam
authors.forename: M
authors.initials: M
authors.lastname: Yang
authors.forename: M H
authors.initials: MH
authors.lastname: Lam
mesh_terms: D000818:Animals; D001315:Australia; D001427:Bacterial Toxins / Q000032:analysis / Q000737:chemistry / Q000506:poisoning / Q000633:toxicity*; D000458:Cyanobacteria / Q000737:chemistry*; D005068:Eutrophication; D005517:Foodborne Diseases / Q000628:therapy; D006801:Humans; D052998:Microcystins; D010456:Peptides, Cyclic / Q000032:analysis / Q000737:chemistry / Q000506:poisoning / Q000633:toxicity*; D012306:Risk
chemical_list: D001427:Bacterial Toxins; D052998:Microcystins; D010456:Peptides, Cyclic; C078588:microcystin