[Effect of modification of the structure of interleukin-1beta on its physiological activity].
Modification of the structure of recombinant human IL-1 beta: deletion of the amino acids serine, asparagine, and asparagic acid in position 52-54 in mutant delta SND, led to major changes in its functional activity. Significant reduction of the main IL-1 beta activities: concomitant, pyrogenic and corticotropic ones in the mutant delta SND, suggests the latter to be a partial agonist of IL-1 beta. Nevertheless the reduction in certain parameters of the humoral immune response in mice following administration of the delta SND preparation suggests that, when manifesting its immunomodulatory properties, the delta SND acts as a partial antagonist of the IL-1 beta.
Rybakina
E G
EG
Institute of Experimental Medicine of the Russian Acad. Med. Sci., St. Petersburg, Russia.
Fomicheva
E E
EE
Pivanovich
I Iu
IIu
Korneva
E A
EA
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003345:Corticosterone / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007375:Interleukin-1 / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D008297:Male; D051379:Mice; D009154:Mutation; D011749:Pyrogens / Q000494:pharmacology; D011817:Rabbits; D011994:Recombinant Proteins / Q000235:genetics / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D000276:Adjuvants, Immunologic; D007074:Immunoglobulin G; D007375:Interleukin-1; D011749:Pyrogens; D011994:Recombinant Proteins; D014284:Triiodothyronine; D013974:Thyroxine; D003345:Corticosterone