[24-h ambulatory monitoring of cardiovascular indices in patients with panic disorders].
24-h monitoring of arterial pressure (AD) and heart rate (HR) was twice performed in 14 patients with panic attacks (in exacerbation and after a course of fluoxetine for 6 weeks). Panic attacks were followed by objective increase of both AD and HR in only 1/3 of the cases and by objective HR increase in 60% of the patients. Although patients with panic attacks were normothymics, hypertensive reactions can arise in them, during sleep for the most part. Alteration of HR variability in sleep-awakening cycle was the most paradoxical (excess HR variability in awakening state and decreased change during a sleep). These alterations of HR variability persisted after control of panic attacks with fluoxetine. This allows to consider HR variability as a factor which reflects predispositional peculiarities of autonomic system functioning in patients with panic disorders.
Vorob'eva
O V
OV
Khapaev
B A
BA
D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D015716:Electrocardiography, Ambulatory / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D008297:Male; D018670:Monitoring, Ambulatory / Q000379:methods*; D016584:Panic Disorder / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D012720:Severity of Illness Index