Efficacy and effectiveness of five day treatment of uncomplicated falciparum with artemisinin or artesunate in Vietnam.
A study on efficacy and effectiveness of artemisinin (total dose of 60 mg/kg) and artesunate (total dose of 12 mg/kg over five days) in treatment of uncomplicated malaria was conducted in highly malaria transmitted areas in Vietnam. 126 uncomplicated malaria cases finished 14 day follow-up. 100% cure rate achieved at day 14 in patients of the efficacy groups received either artemisinin or artesunate, while it was 83% and 93% in patients treated respectively with artemisinin and artesunate of the effectiveness groups. Compliance of the treatment regimens was discussed.
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Institute of Malariology, Parasitology and Entomology, Ha Noi, Vietnam.
Pham
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Nguyen
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Dang
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Pham
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Le
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D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D005334:Fever / Q000469:parasitology; D005500:Follow-Up Studies; D006801:Humans; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use*; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014744:Vietnam
D000962:Antimalarials; D037621:Artemisinins; D007783:Lactones; D012717:Sesquiterpenes; D000077332:Artesunate; C075875:artemisin