Effects of sibutramine alone and with alcohol on cognitive function in healthy volunteers.
OBJECTIVE
To investigate the effects of sibutramine in combination with alcohol in a double-blind, randomised, placebo-controlled, four-way crossover study in 20 healthy volunteers.


METHODS
On each study day each volunteer received either: sibutramine 20 mg+0.5 g kg-1 alcohol; sibutramine 20 mg+placebo alcohol; placebo capsules+0.5 g kg-1 alcohol; or placebo capsules+placebo alcohol. Alcohol was administered 2 h following ingestion of the study capsules. During each study day, assessments of cognitive performance were made prior to dosing, and at 3, 4.5, 6 and 10 h post dosing. Blood alcohol concentration was estimated using a breath alcometer immediately prior to each cognitive performance test session. Each study day was followed by a minimum 7 day washout period.


RESULTS
Alcohol was found to produce statistically significant impairments in tests of attention (maximum impairment to speed of digit vigilance=49 ms) and episodic memory (maximum impairment to speed of word recognition=74 ms). Alcohol also increased body sway (maximum increase 17.4 units) and lowered self rated alertness (maximum decrease 13.6 mm). These effects were produced by an inferred blood alcohol level of 53.2 mg dl-1. Sibutramine was not found to potentiate any of the effects of alcohol. There was a small, yet statistically significant, interaction effect observed on the sensitivity index of the picture recognition task. In this test, the combined effects of sibutramine and alcohol were smaller than the impairments produced by alcohol alone. Sibutramine, when dosed alone, was associated with improved performance on several tasks. Sibutramine improved attention (mean speed of digit vigilance improved by 21 ms), picture recognition speed (improvement at 3=81) and motor control (tracking error at 3 h reduced by 1.58 mm). Also sibutramine improved postural stability (reducing body sway at 3 h by 14.2 units). Adverse events reported were unremarkable and consistent with the known pharmacology of sibutramine and alcohol.


CONCLUSIONS
There was little evidence of a clinically relevant interaction of sibutramine with the impairment of cognitive function produced by alcohol in healthy volunteers. The single statistically significant interaction indicated a reduction, rather than a worsening, of alcohol-induced impairment when sibutramine is taken concomitantly. Sibutramine when administered alone is associated with improved performance on several tasks.
Wesnes
K A
KA
Cognitive Drug Research Limited, Reading; Knoll Pharmaceuticals, Nottingham; Covance Clinical Research Unit, Leeds, UK.
Garratt
C
C
Wickens
M
M
Gudgeon
A
A
Oliver
S
S
D000328:Adult; D001067:Appetite Depressants / Q000009:adverse effects / Q000494:pharmacology*; D001247:Asthenia / Q000139:chemically induced; D002214:Capsules; D002492:Central Nervous System Depressants / Q000009:adverse effects / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D003128:Coma / Q000139:chemically induced; D018592:Cross-Over Studies; D003503:Cyclobutanes / Q000009:adverse effects / Q000494:pharmacology*; D004244:Dizziness / Q000139:chemically induced; D004311:Double-Blind Method; D000431:Ethanol / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects; D016896:Treatment Outcome
D001067:Appetite Depressants; D002214:Capsules; D002492:Central Nervous System Depressants; D003503:Cyclobutanes; D000431:Ethanol; C058254:sibutramine