Recognition of distorted DNA structures by HMG domains.
Recent biochemical and structural studies have shown that the preferential recognition of distorted DNA structures, including DNA bulges, four-way junctions and cis-platinated DNA, by HMG domains is dependent on residues immediately preceding the second alpha helix of the L-shaped HMG domain.
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Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK. aat@mrc-lmb.cam.ac.uk
D000595:Amino Acid Sequence; D004249:DNA Damage; D004260:DNA Repair; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000378:metabolism*; D046911:Macromolecular Substances; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013379:Substrate Specificity
D006609:High Mobility Group Proteins; D046911:Macromolecular Substances