Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats.
Hoyer
S
S
Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Germany.
Lannert
H
H
D000544:Alzheimer Disease / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism; D004958:Estradiol / Q000494:pharmacology; D007276:Injections, Intraventricular; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010101:Oxygen Consumption; D051381:Rats; D011972:Receptor, Insulin / Q000037:antagonists & inhibitors*; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity*
D004958:Estradiol; D013311:Streptozocin; D011972:Receptor, Insulin