[Effects of propyl gallate on histopathology of liver from mice exposed to trinitrotoluene].
In addition to the hepatocellular edema and cytoplasmic eosinophilia, sludging of blood was present in liver of mice exposed to trinitrotoluene(TNT). Single necrosis of the partical liver cell was seen occasionally. Liver damage induced by TNT was significantly alleviated by orally administrated propyl gallate(PG). Futhermore, PG can promote the regeneration of the hepatocytes following TNT-exposed mice. The results suggest that PG showed a protective effect on the histopathologic changes of liver injury induced by TNT.
Li
Z
Z
Institute of North Industrial Health, Xi'an, China.
Yang
J
J
Shi
L
L
Liu
L
L
D000818:Animals; D008099:Liver / Q000473:pathology*; D008115:Liver Regeneration / Q000187:drug effects; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011435:Propyl Gallate / Q000494:pharmacology*; D014303:Trinitrotoluene / Q000633:toxicity*
D014303:Trinitrotoluene; D011435:Propyl Gallate