title: Oral staphylococcal mucositis: A new clinical entity in orofacial granulomatosis and Crohn's disease.
abstract: OBJECTIVE
  Orofacial granulomatosis and the oral manifestations of Crohn's disease comprise many clinical features, of which stomatitis is one. The purpose of this study was to establish a role for Staphylococcus aureus in mucositis affecting some patients with orofacial granulomatosis or oral Crohn's disease.
  
  
  METHODS
  Four patients (2 with orofacial granulomatosis and 2 with oral Crohn's disease), from a total of 450 patients examined over 10 years, had stomatitis involving the entire oral mucosa, from which S aureus was cultured by the oral rinse technique. These patients were treated with flucloxacillin or erythromycin.
  
  
  RESULTS
  A heavy growth of S aureus was isolated from the mouth of each patient. All 4 patients responded to treatment with flucloxacillin or erythromycin.
  
  
  CONCLUSIONS
  S aureus is a potential cause of panstomatitis in patients with orofacial granulomatosis or Crohn's disease. This infection responds rapidly to antimicrobial treatment.
authors.affiliation: University of Glasgow Dental School, Glasgow, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Gibson
authors.forename: D
authors.initials: D
authors.lastname: Wray
authors.forename: J
authors.initials: J
authors.lastname: Bagg
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications*; D004917:Erythromycin / Q000627:therapeutic use; D005145:Face; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use; D006099:Granuloma / Q000150:complications*; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000382:microbiology*; D010406:Penicillins / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000302:isolation & purification; D013280:Stomatitis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D005436:Floxacillin; D004917:Erythromycin