title: Possible relationship between altered fatty acid composition of serum, platelets, and aorta and hypertension induced by sugar feeding in rats.
abstract: To establish a relationship between alterations in fatty acid metabolism, induced by sugar ingestion, and hypertension, we analyzed fatty acid composition of serum, platelets and aorta in rats which had 30% of sugar in their drinking water for 18-20 weeks, and became hypertensive, hypertriglyceridemic and hyperinsulinemic. The fatty acid composition in sugar-fed as compared with that from control rats was as follows: in serum phospholipids, triglycerides and cholesterol ester fractions, palmitic, palmitoleic, oleic and cis-11-eicosadecaenoic acids were present in a higher proportion. In serum phospholipid fraction linoleic and arachidonic acids were decreased and a significant increase was observed in the proportion of dihomo-gamma-linolenic acid. In the membrane phospholipids of platelets and aorta, higher proportions of palmitoleic and of oleic acids were observed. Differences in fatty acid composition of phospholipids between sugar-fed and control rats are consistent with altered membrane fluidity. Altered membrane function is a potential mechanism involved hypertension in rats in sugar-induced.
authors.affiliation: Department of Biochemistry, Instituto Nacional de Cardiología Ignacio Chávez, México. elhafidi@cenids.ssa.gob.mx
authors.forename: M
authors.initials: M
authors.lastname: El Hafidi
authors.forename: R
authors.initials: R
authors.lastname: Valdez
authors.forename: G
authors.initials: G
authors.lastname: Baños
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism*; D015415:Biomarkers; D001792:Blood Platelets / Q000378:metabolism*; D001794:Blood Pressure; D002241:Carbohydrates / Q000633:toxicity*; D002462:Cell Membrane / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000097:blood*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism
chemical_list: D015415:Biomarkers; D002241:Carbohydrates; D002788:Cholesterol Esters; D005227:Fatty Acids; D010743:Phospholipids; D014280:Triglycerides