title: [The role of PMN CD11b/CD18 on the increasing PMN adhesion to endothelial cells induced by severe burn injury].
abstract: The process of leukocyte adhesion was mediated by the intercellular adhesion molecular. In this study, both the influence of burn serum on the expression of PMN CD11b/CD18 and the role of CD11b/CD18 on the burn serum stimulated PMN adhesion to endothelial cells (EC) were investigated. The expression of CD11b/CD18 on PMN incubated with burn serum for 2 hours was increased obviously. So was PMN adhesion to EC. Monoclone antibody to PMN CD11b/CD18 could reduce the normal PMN adhesion to EC by half and block the increasing PMN adhesion induced by burn serum. These indicated that PMN CD11b/CD18 may be the main adhesion molecular participating in the increasing PMN adhesion to EC due to severe burn.
authors.affiliation: Burns Center, Changhai Hospital, Second Military Medical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Fang
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Ge
mesh_terms: D000818:Animals; D002056:Burns / Q000097:blood / Q000503:physiopathology*; D018845:CD11 Antigens / Q000096:biosynthesis*; D018821:CD18 Antigens / Q000096:biosynthesis*; D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology*; D008297:Male; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018845:CD11 Antigens; D018821:CD18 Antigens