title: The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries.
abstract: Enhanced reaction rates are observed when power ultrasound is utilized as a substitute for mixing during solid phase organic chemical reactions on a paramagnetic support. Power ultrasound is also used to facilitate the washing of the paramagnetic support as it is magnetically separated from the reaction mixture. Selective examples from a library targeting the kappa-opioid receptor are presented.
authors.affiliation: Solid Phase Sciences Corporation, Medford, MA 02155, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Perez
authors.forename: E J
authors.initials: EJ
authors.lastname: Wilhelm
authors.forename: I
authors.initials: I
authors.lastname: Sucholeiki
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008280:Magnetics; D019151:Peptide Library; D011759:Pyrrolidines / Q000494:pharmacology; D017473:Receptors, Opioid, kappa / Q000819:agonists; D014465:Ultrasonics
chemical_list: D000577:Amides; D019151:Peptide Library; D011759:Pyrrolidines; D017473:Receptors, Opioid, kappa; C058468:ICI 199441