Local SIgA response following administration of a novel intranasal inactivated influenza virus vaccine in community residing elderly.
Community-residing elderly were immunized twice intranasally three weeks apart with a new inactivated whole influenza vaccine. A control group was immunized intramuscularly with conventional influenza vaccine. Local antibody response was detected in about 50% of intranasally immunized subjects compared to about 20% of intramuscularly immunized subjects, to the three viral strains. Increasing the incidence of elevated IgA response may prevent influenza at its early stages thus reducing complications in the elderly.
Muszkat
M
M
Geriatric Unit, Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Friedman
G
G
Schein
M H
MH
Naveh
P
P
Greenbaum
E
E
Schlesinger
M
M
Zakay-Rones
Z
Z
Yehuda
A B
AB
D000281:Administration, Intranasal; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology*; D000914:Antibodies, Viral / Q000096:biosynthesis; D016022:Case-Control Studies; D006801:Humans; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis*; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D007273:Injections, Intramuscular; D008875:Middle Aged; D009975:Orthomyxoviridae / Q000276:immunology; D015164:Vaccines, Inactivated / Q000008:administration & dosage
D000914:Antibodies, Viral; D007071:Immunoglobulin A, Secretory; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated