Successful induction of ovulation using highly purified follicle-stimulating hormone in a woman with Kallmann's syndrome.
OBJECTIVE
To describe a woman with Kallmann's syndrome who was treated successfully with highly purified FSH to achieve ovulation induction and pregnancy.


METHODS
Case report.


METHODS
University hospital.


METHODS
A 32-year-old woman with Kallmann's syndrome who had been treated with oral contraceptives to prime secondary sex characteristics and genital organs since the age of 16 years.


METHODS
Highly purified FSH was administered intramuscularly for a total dose of 3,825 IU.


METHODS
Follicle number and diameter.


RESULTS
Three follicles with a diameter of > 1.7 cm and an endometrial thickness of 8 mm were observed. A clinical pregnancy, which subsequently was spontaneously aborted, was obtained.


CONCLUSIONS
In primed patients with Kallmann's syndrome, highly purified FSH may be a useful alternative to pulsatile GnRH or menopausal gonadotropins to achieve ovulation induction and pregnancy.
Battaglia
C
C
Department of Obstetrics and Gynecology, University of Modena, Italy. battagli@mail.unimo.it
Salvatori
M
M
Regnani
G
G
Giulini
S
S
Primavera
M R
MR
Volpe
A
A
D000022:Abortion, Spontaneous; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000302:isolation & purification; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial; D017436:Kallmann Syndrome / Q000150:complications*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
D005640:Follicle Stimulating Hormone