title: The chromosome 6 sequencing project at the Sanger Centre.
abstract: Chromosome 6 is probably best known for encoding the major histocompatibility complex (MHC) which is essential to the human immune response. In addition, it has been shown to be associated with many diseases such Schizophrenia, Diabetes, Arthritis, Haemochromatosis, Narcolepsy, Epilepsy, Retinitis Pigmentosa, Deafness, Ovarian Cancer, and many more. Chromosome 6 is about 180 Mb in size and is estimated to encode around 3500 genes of which only about 10% are currently known. It is our aim to map, sequence and annotate the entire chromosome in close collaboration with the chromosome 6 community.
authors.affiliation: The Sanger Centre, Hinxton, England.
authors.forename: T
authors.initials: T
authors.lastname: Avis
authors.forename: E K
authors.initials: EK
authors.lastname: Clark
authors.forename: T L
authors.initials: TL
authors.lastname: Flack
authors.forename: M
authors.initials: M
authors.lastname: Mohammadi
authors.forename: S
authors.initials: S
authors.lastname: Milne
authors.forename: D
authors.initials: D
authors.lastname: Niblett
authors.forename: S
authors.initials: S
authors.lastname: Palmer
authors.forename: S
authors.initials: S
authors.lastname: Phillips
authors.forename: C
authors.initials: C
authors.lastname: Smalley
authors.forename: M
authors.initials: M
authors.lastname: Tagney
authors.forename: K L
authors.initials: KL
authors.lastname: Thorpe
authors.forename: B
authors.initials: B
authors.lastname: Tubby
authors.forename: J
authors.initials: J
authors.lastname: Westhorp
authors.forename: S
authors.initials: S
authors.lastname: Beck
mesh_terms: D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D020451:Contig Mapping; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D017422:Sequence Analysis, DNA