Caenorhabditis elegans: a model genetic host to study Pseudomonas aeruginosa pathogenesis.
In the past year, a Caenorhabditis elegans-Pseudomonas aeruginosa pathogenesis model has been developed to facilitate the systematic dissection of both host and pathogen genes involved in pathogenic interactions. Analysis of the P. aeruginosa-C. elegans interaction should shed light on the larger question of how organisms interact at the molecular level in antagonistic relationships.
Tan
M W
MW
Department of Genetics, Department of Molecular Biology, Wellman 10, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA. tan@genetics.mgh.harvard.edu
Ausubel
F M
FM
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D008954:Models, Biological; D011552:Pseudomonas Infections / Q000276:immunology / Q000503:physiopathology; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000472:pathogenicity*; D014774:Virulence