Leigh syndrome in a 3-year-old boy with unusual brain MR imaging and pathologic findings.
We report unusual MR serial imaging and electron microscopy findings in a 3-year-old boy who had Leigh syndrome with cytochrome-c oxidase (cox) deficiency. The MR imaging findings included periventricular white matter involvement, posteroanterior progression, and extension through the corpus callosum and internal capsule; however, no basal ganglia or brain stem abnormality was found, which was suggestive of leukodystrophy. The most noteworthy findings were the cystic foci with contrast enhancement in the affected white matter.
Topçu
M
M
Hacettepe University, Faculty of Medicine, Department of Child Neurology, Ankara, Turkey.
Saatci
I
I
Apak
R A
RA
Söylemezoglu
F
F
Akçören
Z
Z
D002675:Child, Preschool; D006801:Humans; D007888:Leigh Disease / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male