title: Polymorphonuclear neutrophils are necessary for the recruitment of CD8(+) T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection.
abstract: The role of polymorphonuclear neutrophils (PMNs) in the development of the specific immune response against Chlamydophila abortus (Chlamydia psittaci serotype 1) infection was studied in a pregnant mouse model involving treatment with RB6-8C5 monoclonal antibody. PMN depletion significantly affected the immune response in the liver, in which the T-lymphocyte and F4/80(+) cell populations decreased, particularly the CD8(+) T-cell population. A Th1-like response, characterized by high levels of gamma interferon without detectable levels of interleukin 4 (IL-4) in serum, was observed in both depleted and nondepleted mice, although an increased production of IL-10 was detected in the depleted group. Our results suggest that PMNs play a very important role in the recruitment of other leukocyte populations to the inflammatory foci but have little influence in the polarization of the immune specific response toward a Th1-like response.
authors.affiliation: Departamento de Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain.
authors.forename: R M
authors.initials: RM
authors.lastname: de Oca
authors.forename: A J
authors.initials: AJ
authors.lastname: Buendía
authors.forename: L
authors.initials: L
authors.lastname: Del Río
authors.forename: J
authors.initials: J
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Salinas
authors.forename: J A
authors.initials: JA
authors.lastname: Navarro
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D002465:Cell Movement; D005260:Female; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008099:Liver / Q000276:immunology*; D051379:Mice; D009504:Neutrophils / Q000502:physiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D009956:Psittacosis / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma