title: Adjunctive therapy in sepsis: a critical analysis of the clinical trial programme.
abstract: Despite intensive efforts, the development of novel drugs for the treatment of sepsis has proved to be extremely difficult. A large number of clinical trials have ended in failure. A critical analysis of this record suggests that there is no single reason for these problems. Rather, the explanation lies in part with unexpected failures in the drugs themselves, and in part with the difficulties of trial design in this particular group of patients. In future, trials in this area are likely to be more highly focused, with even stricter protocol definitions to try and ensure a homogeneous patient population.
authors.affiliation: Department of Infectious Diseases and Microbiology, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Cohen
mesh_terms: D004731:Endotoxins / Q000037:antagonists & inhibitors; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D018805:Sepsis / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha