title: Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.
abstract: Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.
authors.affiliation: Ophthalmology Research Laboratories, Cedars-Sinai Medical Center Burns & Allen Research Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Perng
authors.forename: C
authors.initials: C
authors.lastname: Jones
authors.forename: J
authors.initials: J
authors.lastname: Ciacci-Zanella
authors.forename: M
authors.initials: M
authors.lastname: Stone
authors.forename: G
authors.initials: G
authors.lastname: Henderson
authors.forename: A
authors.initials: A
authors.lastname: Yukht
authors.forename: S M
authors.initials: SM
authors.lastname: Slanina
authors.forename: F M
authors.initials: FM
authors.lastname: Hofman
authors.forename: H
authors.initials: H
authors.lastname: Ghiasi
authors.forename: A B
authors.initials: AB
authors.lastname: Nesburn
authors.forename: S L
authors.initials: SL
authors.lastname: Wechsler
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D005814:Genes, Viral; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000502:physiology*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D016849:Keratitis, Herpetic / Q000473:pathology* / Q000821:virology*; D009154:Mutation; D009474:Neurons / Q000473:pathology* / Q000821:virology; D011065:Poly(ADP-ribose) Polymerases / Q000276:immunology / Q000378:metabolism; D011817:Rabbits; D014158:Transcription, Genetic; D012668:Trigeminal Ganglion / Q000473:pathology / Q000821:virology; D014775:Virus Activation; D017735:Virus Latency / Q000235:genetics*
chemical_list: D011065:Poly(ADP-ribose) Polymerases