title: Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability.
authors.affiliation: Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: C N
authors.initials: CN
authors.lastname: Serhan
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: N
authors.initials: N
authors.lastname: Chiang
authors.forename: K
authors.initials: K
authors.lastname: Gronert
authors.forename: C B
authors.initials: CB
authors.lastname: Clish
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000097:blood* / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D001707:Biopsy, Needle; D002199:Capillary Permeability / Q000187:drug effects*; D003864:Depression, Chemical; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000139:chemically induced / Q000503:physiopathology; D004431:Ear, External / Q000473:pathology; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism*; D008055:Lipids / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D020556:Neutrophil Infiltration / Q000187:drug effects*; D010538:Peritonitis / Q000139:chemically induced / Q000503:physiopathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001095:Arachidonic Acids; D018836:Inflammation Mediators; D008055:Lipids; D015118:Eicosapentaenoic Acid; D001241:Aspirin