Serum inhibin B concentration in a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome.
Gynecomastia in boys with Peutz-Jeghers syndrome and Sertoli cell tumors of gonadal origin results from increased estrogen production due to increased aromatase activity within the testicular tumor. We present a prepubertal boy with Peutz-Jeghers syndrome, gynecomastia and bilateral neoplastic Sertoli cell proliferation in whom the only abnormal hormonal profile was increased concentration of inhibin B and Pro-alpha C in serum.
Bergadá
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División de Endocrinología, Hospital de Niños, R. Gutiérrez, Buenos Aires, Argentina.
Del Toro
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Katz
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Chemes
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Campo
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D001706:Biopsy; D002455:Cell Division; D002648:Child; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D006177:Gynecomastia / Q000097:blood* / Q000601:surgery; D006801:Humans; D007265:Inhibins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010580:Peutz-Jeghers Syndrome / Q000097:blood*; D012707:Sertoli Cell Tumor / Q000473:pathology; D013736:Testicular Neoplasms / Q000473:pathology
C015856:estrone-3-glucuronide; D004970:Estrone; D004958:Estradiol; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone