Transgenic models as tools for studying the regulation of human renin expression.
Transgenic mice and rats have become popular tools to study the regulation of gene expression and the consequences of protein over-production. Over the past decade, numerous transgenic models have been developed to study the mechanisms of human renin gene expression and the participation of the renin-angiotensin system in the development of hypertension. Herein we will provide an overview of what has been learned from the use of transgenic models for studying the human renin gene.
Sinn
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Department of Internal Medicine, The University of Iowa College of Medicine, Iowa City 52242, USA.
Sigmund
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D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics / Q000378:metabolism*; D000957:Antigens, Viral, Tumor / Q000235:genetics; D004195:Disease Models, Animal; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D051379:Mice; D051381:Rats; D012083:Renin / Q000096:biosynthesis* / Q000235:genetics; D012084:Renin-Angiotensin System / Q000502:physiology
D000957:Antigens, Viral, Tumor; D012083:Renin