title: Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.
abstract: Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 microM, but inhibited 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 microM.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Inokoshi
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: R
authors.initials: R
authors.lastname: Masuma
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D001234:Aspergillus niger / Q000145:classification / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D007659:Ketones; D061965:Matrix Metalloproteinase Inhibitors; D011083:Polycyclic Compounds; D011480:Protease Inhibitors; C405054:funalenone