Regulation of endocytic traffic by rho family GTPases.
Endocytosis is a complicated yet highly efficient process that involves the uptake and processing of cargoes, ranging from small molecules, to activated signalling receptors, to whole microorganisms. Regulation of endocytic pathways is poorly understood. Recent evidence suggests that the Rho GTPase family of signalling proteins is intimately involved in endocytic traffic, providing novel insights into the control mechanisms that govern this process.
Ellis
S
S
Dept of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, UK.
Mellor
H
H
D016475:3T3 Cells; D000818:Animals; D002460:Cell Line; D016764:Cell Polarity / Q000502:physiology; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000201:enzymology; D051379:Mice; D010587:Phagocytosis / Q000502:physiology; D010873:Pinocytosis / Q000502:physiology; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D014981:Xenopus; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000378:metabolism*; D020742:rhoA GTP-Binding Protein / Q000378:metabolism; D020743:rhoB GTP-Binding Protein / Q000378:metabolism
D002966:Clathrin; D011506:Proteins; C491334:Rhod protein, mouse; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins; D020741:rho GTP-Binding Proteins; D020742:rhoA GTP-Binding Protein; D020743:rhoB GTP-Binding Protein