Impact of cyclosporin A pharmacokinetics on the presence of side effects in pediatric renal transplantation.
Cyclosporin A (CsA) is a potent immunosuppressant that has many side effects, including hypertrichosis, gingival hyperplasia, and tremor. To evaluate whether there is a relationship between the CsA-pharmacokinetics (PK) and these side effects, their presence and intensity were observed in 46 renal transplanted children/adolescents during two regular visits, and the occurrence of the side effects was correlated with CsA-PK. CsA doses had been unchanged for at least 6 mo. CsA blood concentrations were measured at time 0, and 1, 2, and 4 h after the CsA morning dose. An abbreviated area under the curve (AUC) was calculated using C0, C2, and C4. Hypertrichosis positively correlated with C2, C4, Cmax, and AUC. An AUC > or = 4158 ng/ml per h was the best predictor for the presence of hypertrichosis. Tremor was also positively correlated with C2, Cmax, and AUC. A Cmax > or = 878 ng/ml was the best predictor for the appearance of tremor. These values of Cmax and AUC are within the therapeutic range of CsA as demonstrated by the studies of calcineurin inhibition by CsA. Gingival hyperplasia was not associated with any of the CsA-PK studied parameters. However, it was associated with the concomitant use of nifedipine. These data show that there is a correlation between the CsA side effects and its pharmacokinetics and that it is possible to decrease the incidence and intensity of such side effects by monitoring the CsA-PK parameters, providing they are under or at the proposed cutoff levels. Nifedipine should also be avoided to reduce the presence of gingival hyperplasia.
David-Neto
Elias
E
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Lemos
Francine Brambate Carvalhinho
FBC
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Arai Furusawa
Erika
E
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Schwartzman
Benita Soares
BS
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Cavalcante
Juliana Soares
JS
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Yagyu
Elisa Midori
EM
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Romano
Paschoalina
P
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
Ianhez
Luis Estevan
LE
Renal Transplantation Unit, Hospital das Clínicas of the University of São Paulo School of Medicine, São Paulo, Brazil.
D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects* / Q000493:pharmacokinetics*; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced; D006225:Hand; D006801:Humans; D006983:Hypertrichosis / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000493:pharmacokinetics*; D016030:Kidney Transplantation; D008297:Male; D009543:Nifedipine / Q000009:adverse effects; D011184:Postoperative Period; D014202:Tremor / Q000139:chemically induced
D000959:Antihypertensive Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009543:Nifedipine