Reversible lesions of the rhinal cortex produce delayed non-matching-to-sample deficits in rats.
Rats with cannulae guides implanted in the rhinal cortex were tested on a delayed non-matching-to-sample task, following either lidocaine or sham microinfusions. Bilateral lidocaine microinfusions to the rhinal cortex produced significant delayed non-matching-to-sample deficits. These results are consistent with the putative role of the rhinal cortex in object recognition but because the deficits were not shown to be time dependent, non-mnemonic interpretations cannot be ruled out. These results also illustrate the utility of reversible lidocaine lesions in the study of the neuroanatomical basis of delayed non-matching-to-sample.
Barnes
S J
SJ
Department of Psychology, University of British Columbia, Vancouver, Canada.
Floresco
S B
SB
Kornecook
T J
TJ
Pinel
J P
JP
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002404:Catheterization; D004193:Discrimination Learning / Q000187:drug effects; D018728:Entorhinal Cortex / Q000187:drug effects / Q000502:physiology*; D008012:Lidocaine / Q000008:administration & dosage; D008297:Male; D008568:Memory / Q000187:drug effects; D008845:Microinjections; D051381:Rats; D020318:Rats, Long-Evans; D011930:Reaction Time / Q000187:drug effects
D008012:Lidocaine