Sustained drug release characteristics of biodegradable composite poly(d,l)lactic acid-poly(l)lactic acid microcapsules containing ciprofloxacin.
Ciprofloxacin polylactic microcapsules were prepared by the phase separation process. Two types of polylactic acid, poly(d,l)lactic acid and poly(l)lactic acid were combined as membrane materials to prevent the aggregation which happened frequently in the phase separation process. The polymer compositions of the microcapsules can influence the release rate of Ciprofloxacin. The optimal release rate of the drug can be obtained by modifying microcapsule compositions. Poly(d,l)lactic acid is superior in slowing the rate of drug release than poly(l)lactic acid. However, poly(l)lactic acid is necessary in the preparation of the microcapsules to prevent aggregation.
Yu
W P
WP
Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Wong
J P
JP
Chang
T M
TM
D000890:Anti-Infective Agents / Q000494:pharmacology; D001673:Biodegradation, Environmental; D002214:Capsules; D002939:Ciprofloxacin / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004356:Drug Storage; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D002939:Ciprofloxacin