[Effects of mifepristone on ICE expression and Fas expression in early pregnant chorionic villi].
This study addressed the question whether mifepristone has any effect on apoptosis in early pregnant chorionic villi. Interleukin 1 beta converting enzyme(ICE) expression and Fas expression in early pregnant villi and their changes following mifepristone administration were detected by immunohistochmical method and computer image analysis. During early pregnancy, ICE and Fas were expressed in all component chorionic cells, predominantly syncytiotrophoblasts. ICE stained cytoplasma. Fas stained mainly cytoplasma, and in partial trophoblastic cells, Fas was expressed on membrane and nucleus. In the villi from the pregnant women who received mifepristone for 2 days, expression of Fas increased markely; the ratio of positive nuclear staining cells were significantly raised, but the immunostaining intensity of ICE was slightly increased. These results suggest that mifepristone may terminate early pregnancy via increasing the expression of Fas and promoting apoptosis in the chorionic villi.
Yang
Y
Y
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chengdu.
Han
Z
Z
Cao
Z
Z
Li
S
S
Wang
H
H
Liu
W
W
D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D020170:Caspase 1 / Q000096:biosynthesis*; D002824:Chorionic Villi / Q000378:metabolism*; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D019014:fas Receptor / Q000096:biosynthesis*
D000021:Abortifacient Agents, Steroidal; D019014:fas Receptor; D015735:Mifepristone; D020170:Caspase 1