title: Learning and memory in mice treated with choline oxidase, a hydrolytic enzyme for choline.
abstract: Learning and maintenance of memory in mice intraperitoneally (IP) injected with choline oxidase (ChO, 6 units/g), a hydrolytic enzyme for choline (Ch), were assessed by means of a step-through passive-avoidance task. The ChO treatment induced a hydrolysis of free Ch in plasma, which in turn, induced a decrease in cerebral acetylcholine (ACh) release. In the learning test, the ChO-treated mice showed significant inhibition to learn the avoidance from electric shock. In the retention test, the impairment of the memory once established was not produced by posttreated ChO. We concluded that the decreased cerebral cholinergic neurotransmission induced by ChO retarded acquisition of passive-avoidance learning more readily than the maintenance of memory.
authors.affiliation: Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi-shi, Gunma, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ikarashi
authors.forename: H
authors.initials: H
authors.lastname: Kuribara
authors.forename: T
authors.initials: T
authors.lastname: Shiobara
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ishimaru
authors.forename: Y
authors.initials: Y
authors.lastname: Maruyama
mesh_terms: D000429:Alcohol Oxidoreductases / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002794:Choline / Q000097:blood; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000429:Alcohol Oxidoreductases; C019888:choline oxidase; D002794:Choline