From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility.
The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.
Lanier
L M
LM
Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Imlanier@mit.edu
Gertler
F B
FB
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D029721:Drosophila Proteins; D020439:Growth Cones / Q000201:enzymology* / Q000502:physiology*; D010766:Phosphorylation; D011485:Protein Binding; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D016315:Proto-Oncogene Proteins c-abl / Q000378:metabolism*; D054557:Receptor-Like Protein Tyrosine Phosphatases; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D016315:Proto-Oncogene Proteins c-abl; C117978:Lar protein, Drosophila; D017027:Protein Tyrosine Phosphatases; D054557:Receptor-Like Protein Tyrosine Phosphatases; D020741:rho GTP-Binding Proteins