Analysis of TAP and HLA-DM polymorphism in thai rheumatoid arthritis.
Rheumatoid arthritis is an autoimmune disease with a strong association with DR4 in many populations. In the Thai population, rheumatoid arthritis is associated with DRB1*0405. To evaluate the role of polymorphism in TAP and HLA-DM genes, which are important in antigen processing and presentation in predisposition to rheumatoid arthritis, 82 Thai patients with rheumatoid arthritis and 100 unrelated normal controls were studied. TAP and HLA-DM typing was performed by ARMS-PCR and PCR-SSO method, respectively. There was no difference in the distribution of TAP1, TAP2, DMA, and DMB genes between the patients and controls. This study suggested that TAP and HLA-DM genes do not confer susceptibility to rheumatoid arthritis.
Vejbaesya
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S
Department of Transfusion Medicine, Bangkok, Thailand. sisve@mahidol.ac.th
Luangtrakool
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P
Luangtrakool
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K
Sermduangprateep
C
C
Parivisutt
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L
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000368:Aged; D017951:Antigen Presentation / Q000235:genetics; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000235:genetics*; D000939:Epitopes; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006681:HLA-D Antigens / Q000235:genetics*; D006683:HLA-DQ Antigens / Q000235:genetics; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D013785:Thailand
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D000939:Epitopes; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; C073119:TAP1 protein, human; C071692:TAP2 protein, human