Simultaneous optimization of the analysis time and the concentration detectability in open-tubular liquid chromatography.
Scott's OT-LC minimal analysis time problem has been solved analytically and has been extended to thick-film and/or large diameter columns. The optimisation analysis has also been applied to a number of relative performance indexes (Cmax/t(anal), Cmax x d/t(anal) and Cmax x u x d2/t(anal) which provide a quantitative insight on the extent to which OT-LC allows to combine short analysis times with a large concentration detectability.
Desmet
G
G
Vrije Universiteit Brussel, Department of Chemical Engineering, Brussels, Belgium. gedesmet@vub.ac.be
Baron
G V
GV
D002853:Chromatography, Liquid / Q000379:methods*; D008956:Models, Chemical; D012680:Sensitivity and Specificity