title: NF-kappaB and the innate immune response.
abstract: In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-kappaB (NFkappaB). NF-kappaB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-kappaB have been clarified by gene inactivation and biochemical analysis.
authors.affiliation: Max-Delbrück-Center for Molecular Medicine, Berlin, 13122, Germany.
authors.forename: E N
authors.initials: EN
authors.lastname: Hatada
authors.forename: D
authors.initials: D
authors.lastname: Krappmann
authors.forename: C
authors.initials: C
authors.lastname: Scheidereit
mesh_terms: D004789:Enzyme Activation; D051550:I-kappa B Kinase; D007113:Immunity, Innate; D016328:NF-kappa B / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D014774:Virulence / Q000276:immunology
chemical_list: D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase