title: Intron splice acceptor site polymorphism in the hMSH2 gene in sporadic and familial colorectal cancer.
abstract: A polymorphism in hMSH2 gene has been associated with an increased susceptibility to develop colorectal cancer (CRC). Here we show that it is a genetic risk factor for CRC in the Spanish population. However, its presence does not apparently affect hMSH2 function.
authors.affiliation: Laboratori d'Investigació Gastrointestinal, Institut de Recerca, Hospital de Sant Pau, Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Palicio
authors.forename: I
authors.initials: I
authors.lastname: Blanco
authors.forename: S
authors.initials: S
authors.lastname: Tórtola
authors.forename: I
authors.initials: I
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: Marcuello
authors.forename: J
authors.initials: J
authors.lastname: Brunet
authors.forename: F
authors.initials: F
authors.lastname: Lluis
authors.forename: J J
authors.initials: JJ
authors.lastname: González-Aguilera
authors.forename: M A
authors.initials: MA
authors.lastname: Peinado
authors.forename: G
authors.initials: G
authors.lastname: Capella
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017398:Alternative Splicing; D001483:Base Sequence; D015179:Colorectal Neoplasms / Q000235:genetics*; D017931:DNA Primers; D004268:DNA-Binding Proteins; D005091:Exons; D006801:Humans; D007438:Introns; D008875:Middle Aged; D051718:MutS Homolog 2 Protein; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*
chemical_list: D017931:DNA Primers; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein