[Reversal of cancer multidrug resistance by Chinese medicine Ams-11, Fw-13 and Tul-17].
The aim of this project was to find some kinds of Chinese materia medica as effective agents for in vitro reversal of cancer multidrug resistance. Based on the present authors' previous researches, thirty-two kinds of Chinese medicine as research meterials were selected and examined. Using cell growth inhibit assay, the authors found that three of them--Ams-11, Fw-13 and Tul-17 in the doses free from cytotoxity could enhance the sensitivity of multidrug resistant cells to anti-cancer drugs in a dose-dependent way. It seemed that these three kinds of Chinese medicine might be potential effective reversal agents.
Li
D
D
Lab of Molecular Biology, School of Basic Medical Sciences, Chengdu.
Qu
Y
Y
Liu
B
B
Tang
X
X
Zhang
T
T
Ouyang
X
X
Liu
S
S
D002470:Cell Survival; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology; D014407:Tumor Cells, Cultured
D004365:Drugs, Chinese Herbal