[The balance of elastase and its inhibitors in the vascular tissues of rabbits of different ages in the early stages of experimental Mönckeberg-type arteriosclerosis].
The role of the elastolytic system in pathogenesis of vascular diseases was investigated on adult and one-month old rabbits in experimental ergocalciferol-induced media calcinosis depending on age aspect. The obtained results indicate that elastase activity was increased in aortic homogenates of one-month old rabbits but not in adult animals. The level of alpha 1-proteinase inhibitor is reduced in one-month old rabbits, and decrease of the alpha 2-macroglobulin content in arterial walls occurs in adults. A higher level of antielastase proteins in both groups of animals in venous vessels is determined. After effect of ergocalciferol in the veins of one-month-old rabbits, differs from the adults, a significant increase of the inhibitor content is observed. The presented results confirm the importance of balance between elastase and it inhibitors in pathogenesis of arteriosclerosis.
Dosenko
V Ie
VIe
A. A. Bogomolets National Medical University, Kiev.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001161:Arteriosclerosis / Q000097:blood / Q000139:chemically induced / Q000201:enzymology*; D001808:Blood Vessels / Q000201:enzymology*; D002114:Calcinosis / Q000097:blood / Q000139:chemically induced / Q000196:embryology*; D004195:Disease Models, Animal; D004872:Ergocalciferols; D006868:Hydrolysis; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011817:Rabbits; D018709:Statistics, Nonparametric; D013379:Substrate Specificity; D013997:Time Factors; D017540:Tunica Media / Q000201:enzymology*
D004872:Ergocalciferols; D010196:Pancreatic Elastase