title: Effect of crude extracts of Erythrina americana Mill. on aggressive behavior in rats.
abstract: Three alkaloid fractions were obtained from seeds of Erythrina americana: free alkaloids in hexane, free alkaloids in methanol and liberated alkaloids. The pharmacological evaluation of these fractions on rats showed that, administered in a dose of 3 mg/kg, the three fractions diminished the aggressive behavior. This is comparable when diazepam is used as a control. An interaction between the cholinergic and GABAergic system could be suggested.
authors.affiliation: ENEP-Iztacala, UNAM. Tlalnepantla, Edo. de Méx., Mexico.
authors.forename: M E
authors.initials: ME
authors.lastname: Garín-Aguilar
authors.forename: J E
authors.initials: JE
authors.lastname: Luna
authors.forename: M
authors.initials: M
authors.lastname: Soto-Hernández
authors.forename: G
authors.initials: G
authors.lastname: Valencia del Toro
authors.forename: M M
authors.initials: MM
authors.lastname: Vázquez
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D004895:Erythrina / Q000737:chemistry*; D007928:Lethal Dose 50; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013997:Time Factors
chemical_list: D000470:Alkaloids; D010936:Plant Extracts; D003975:Diazepam