Testing mode of inheritance of a candidate mutation at a quantitative trait locus.
Here is presented an approach to testing whether the effect of a candidate gene on a quantitative trait is dominant and for testing whether the effect is recessive. The approach uses parental genotype information in nuclear families to adjust for bias due to population admixture. The approach is applicable regardless of the nature of the sampling. The results of an application of the methods to a candidate mutation for diabetic nephropathy are used for illustration.
Rabinowitz
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D
Department of Statistics, Columbia University, New York, N.Y., USA.
Zanchi
A
A
Schaumberg
D
D
Krolewski
A
A
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics; D003928:Diabetic Nephropathies / Q000235:genetics*; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D019655:Quantitative Trait, Heritable