title: [Structure and diversity of the mitochondrial gene pool of the aboriginal population of Tuva and Buriatia from restriction polymorphism data].
abstract: The populations of Tuvinians (N = 36) and Buryats (N = 105) were characterized by using the data on mitochondrial DNA (mtDNA) polymorphism. The gene pools of both ethnic groups possessed the mtDNA types belonging to the four main haplogroups, A, B, C, and D, found only in the indigenous populations of Asia and America. The total frequencies of the A, B, C, and D haplogroups in Tuvinians and Buryats were 72.3% and 52.4%, respectively. These values, along with the frequency for Altai populations (57.2%), were highest in the Asian populations studied, indicating that the populations Southern and Eastern Siberia can be considered as ancestral relatives to the ethnic groups of the New World. Analysis of the mtDNA region V polymorphism showed the presence of 9-bp deletion and 4-bp insertion in both populations with frequencies respectively of 13.9 and 5.56% in Tuvinians and 4.8 and 1.9% in Buryats. The frequency of the +AvaII/8249 variant was 11.1% in Tuvinians and 3.81% in Buryats. Analysis of the association between the region V deletion-insertion polymorphism and certain restriction haplogroups pointed to repeated and independent emergence of the 4-bp insertion in Siberia.
authors.affiliation: Institute of Biological Problems of the Far North, Russian Academy of Sciences, Magadan, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Derenko
authors.forename: I K
authors.initials: IK
authors.lastname: Dambueva
authors.forename: B A
authors.initials: BA
authors.lastname: Maliarchuk
authors.forename: Ch M
authors.initials: ChM
authors.lastname: Dorzhu
authors.forename: I A
authors.initials: IA
authors.lastname: Zakharov
mesh_terms: D001483:Base Sequence; D017931:DNA Primers; D004272:DNA, Mitochondrial / Q000235:genetics*; D005006:Ethnicity; D005788:Gene Pool; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D044469:Racial Groups; D012800:Siberia
chemical_list: D017931:DNA Primers; D004272:DNA, Mitochondrial