title: [Outline of the problem of indices of therapeutic efficacy. 4. Expression of efficacy when the underlying illness is incurable. Study Group for the Indices of Efficacy].
abstract: In chronic illness, when death or a non-fatal event can occur at any time, the current efficacy indices are no longer appropriate to express the effect of the treatment on the potential therapeutic objectives. The inappropriateness is not dependent on the effect model. Clues for solutions are proposed.
authors.affiliation: Service de pharmacologie clinique, Université Cluade Bernard, Lyon, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Boissel
authors.forename: M
authors.initials: M
authors.lastname: Cucherat
authors.forename: G
authors.initials: G
authors.lastname: Chatellier
authors.forename: M
authors.initials: M
authors.lastname: Buyse
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Boutitie
authors.forename: P
authors.initials: P
authors.lastname: Nony
authors.forename: F
authors.initials: F
authors.lastname: Gueyffier
authors.forename: M
authors.initials: M
authors.lastname: Haugh
authors.forename: G
authors.initials: G
authors.lastname: Mignot
mesh_terms: D002908:Chronic Disease / Q000188:drug therapy; D004341:Drug Evaluation / Q000379:methods*; D004358:Drug Therapy / Q000592:standards; D006801:Humans; D016896:Treatment Outcome