title: Preparation and characterisation of a new insoluble polymorphic form of glibenclamide.
abstract: A crystalline form of glibenclamide, with higher melting point (218 degrees C) and lower solubility in simulated gastric and intestinal fluids, was arisen during an attempt to elucidate transitional phases by melting, cooling and reheating. The new form was obtained from the glassy state, by applying sublimation at 130-160 degrees C and was characterised by differential scanning calorimetry (DSC), infrared (IR) spectroscopy, scanning electron microscopy (SEM), hot-stage microscopy (HSM), X-ray powder diffraction (XRD) and solubility studies. Formation of the new crystal form is considered as reason of reduction in dissolution and bioavailability of tablets.
authors.affiliation: Department of Pharmaceutical Technology, School of Pharmacy, University of Thessaloniki, Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Panagopoulou-Kaplani
authors.forename: S
authors.initials: S
authors.lastname: Malamataris
mesh_terms: D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D005905:Glyburide / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D013678:Technology, Pharmaceutical
chemical_list: D007004:Hypoglycemic Agents; D005905:Glyburide