title: [Free-radical processes under different conditions of body oxygen allowance].
abstract: Free radical processes (FRP) in mammalian organism are oxygen-depended. The review is devoted to the analysis of pro- and antioxidant processes in mammalian tissues under different oxygen supply conditions. There are described: sources of free radicals; hyperproduction of FRP under hyperoxia and hyperbaria; the role of free radicals in the adaptation to chronic hypoxia (high altitudes, barochamber, chronic heart and lung diseases); production of active oxygen species during the reoxygenation of preliminarily hypoxic tissues; FRP under intermittent hypoxic training; role of FRP in the chemoreception of oxygen. The special attention is paid to three main factors underlined the FR production in hypoxic conditions: the speed of hypoxia increase, the degree of hypoxia and the time of hypoxic exposure.
authors.affiliation: A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
authors.forename: T V
authors.initials: TV
authors.lastname: Serebrovs'ka
authors.forename: O S
authors.initials: OS
authors.lastname: Safronova
authors.forename: S K
authors.initials: SK
authors.lastname: Hordiĭ
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001273:Atmosphere Exposure Chambers; D005609:Free Radicals / Q000378:metabolism*; D018496:Hyperoxia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology*; D010313:Partial Pressure
chemical_list: D005609:Free Radicals