Immunophilins: their properties and their potential role in therapeutic drug monitoring.
This article reviews recent developments in the immunophilin arena and the current state of knowledge about the biochemical properties of immunophilins. The role of immunophilin-binding assays is also explored with the conclusion that some of these immunosuppressive-drug-binding proteins may provide better assays for sirolimus and tacrolimus than current immunoassays.
Soldin
S J
SJ
Department of Laboratory Medicine, Children's National Medical Center, Washington, DC 20010, USA.
D000818:Animals; D016903:Drug Monitoring; D006801:Humans; D020104:Immunophilins / Q000378:metabolism*; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000627:therapeutic use; D008024:Ligands; D011955:Receptors, Drug / Q000378:metabolism
D007166:Immunosuppressive Agents; D008024:Ligands; D011955:Receptors, Drug; D020104:Immunophilins