The pharmacogenetics of beta2-adrenergic receptors: relevance to asthma.
The beta(2)-adrenergic receptor (beta(2)AR) is the molecular target for beta-agonists used in the treatment of asthma. In the human population, 4 polymorphisms of the beta(2)AR coding block have been found, 3 of which result in receptors that have different properties compared with wild-type. To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to beta-agonist therapy, making these variants the first of undoubtedly several genetic loci that will ultimately be found that will provide for individualized therapy in asthma.
Liggett
S B
SB
Departments of Medicine and Molecular Genetics, University of Cincinnati College of Medicine, Ohio, USA.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000595:Amino Acid Sequence; D001249:Asthma / Q000188:drug therapy* / Q000235:genetics*; D002986:Clinical Trials as Topic; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D011943:Receptors, Adrenergic, beta / Q000235:genetics*
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta