title: Effect of Ocimum sanctum roots extract on swimming performance in mice.
abstract: The effect of a methanol extract, obtained from the roots of Ocimum sanctum, on mouse swimming performance were studied using three different doses. On the basis of our findings, a high dose (400 mg/kg, i.p.) of the extracts of Ocimum sanctum increased the swimming time suggesting a central nervous system stimulant and/or antistress activity. The effect produced by the extract was comparable to that of desipramine, an antidepressant drug.
authors.affiliation: College of Pharmaceutical Sciences, Mohuda, Berhampur, Ganjam, Orissa - 760 002, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Maity
authors.forename: S C
authors.initials: SC
authors.lastname: Mandal
authors.forename: B P
authors.initials: BP
authors.lastname: Saha
authors.forename: M
authors.initials: M
authors.lastname: Pal
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D018649:Ocimum basilicum; D005082:Physical Exertion / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots; D013550:Swimming
chemical_list: D000929:Antidepressive Agents, Tricyclic; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D003891:Desipramine