title: Capillary electrophoretic determination of sanguinarine and chelerythrine in plant extracts and pharmaceutical preparations.
abstract: Capillary electrophoresis was employed to determine the principal quaternary benzo[c]phenanthridine alkaloids, sanguinarine and chelerythrine, in two plant extracts and one oral hygiene product. Phosphate-Tris buffer of pH 2.5 was used as a background electrolyte, limits of detection were 3 micromol/l(-1) (sanguinarine) and 2.4 micromol,l(-1) (chelerythrine) using UV detection at 270 nm. The method, which correlated well with HPLC, is suitable for serial determination of sanguinarine and chelerythrine in plant products and pharmaceuticals.
authors.affiliation: Department of Analytical Chemistry, Palacký University, Olomouc, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Sevcík
authors.forename: J
authors.initials: J
authors.lastname: Vicar
authors.forename: J
authors.initials: J
authors.lastname: Ulrichová
authors.forename: I
authors.initials: I
authors.lastname: Válka
authors.forename: K
authors.initials: K
authors.lastname: Lemr
authors.forename: V
authors.initials: V
authors.lastname: Simánek
mesh_terms: D000470:Alkaloids / Q000032:analysis*; D053119:Benzophenanthridines; D002851:Chromatography, High Pressure Liquid; D019075:Electrophoresis, Capillary / Q000379:methods*; D007546:Isoquinolines; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010617:Phenanthridines / Q000032:analysis*; D010936:Plant Extracts / Q000737:chemistry*; D012680:Sensitivity and Specificity
chemical_list: D000470:Alkaloids; D053119:Benzophenanthridines; D007546:Isoquinolines; D004364:Pharmaceutical Preparations; D010617:Phenanthridines; D010936:Plant Extracts; C005705:sanguinarine; C016299:chelerythrine