Actin machinery: pushing the envelope.
The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.
Borisy
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GG
Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA. ggborisy@facstaff.wisc.edu
Svitkina
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TM
D051339:Actin Depolymerizing Factors; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000378:metabolism*; D000818:Animals; D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D003712:Dendrites / Q000378:metabolism; D051345:Destrin; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D051304:Profilins
C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051339:Actin Depolymerizing Factors; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D051345:Destrin; D008840:Microfilament Proteins; D020409:Molecular Motor Proteins; C495738:PFN1 protein, human; D051304:Profilins