title: Treatment of infant colic with amino acid-based infant formula: a preliminary study.
abstract: Infant colic, a common disorder of infancy, is characterized by excessive crying and fussing. In this preliminary study we examined whether Neocate, an amino acid-based formula, would be accepted by formula-fed infants with colic, 3-7 wk of age, and whether Neocate would improve their symptoms. Six infants with colic were studied using Barr-type infant behavior diaries for 3-6 d on their current formula and then for 5-17 d on Neocate exclusively. All infants tolerated Neocate well and all improved, usually within 1-2 d. The total time spent crying and fussing was reduced by an average of 45%, representing a decrease of 1.0 to 5.2 h daily. After colic symptoms improved, infants were challenged with oral doses of 75 mg of bovine IgG at a 1 mg/ml concentration in order to assess its potential role in colic. Bovine IgG challenges resulted in increased crying and fussing behavior, suggesting that this protein may be etiologically important.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Estep
authors.forename: A
authors.initials: A
authors.lastname: Kulczycki
mesh_terms: D000284:Administration, Oral; D000596:Amino Acids / Q000008:administration & dosage*; D000818:Animals; D002241:Carbohydrates / Q000008:administration & dosage*; D002417:Cattle; D003085:Colic / Q000178:diet therapy* / Q000209:etiology; D003448:Crying; D004041:Dietary Fats / Q000008:administration & dosage*; D005526:Food, Formulated; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000276:immunology; D007223:Infant; D018730:Infant Behavior; D007225:Infant Food; D007231:Infant, Newborn; D008297:Male; D016269:Milk Hypersensitivity / Q000150:complications; D013997:Time Factors
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D004041:Dietary Fats; D007074:Immunoglobulin G; C076533:Neocate