title: Actin machinery: pushing the envelope.
abstract: The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility.
authors.affiliation: Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA. ggborisy@facstaff.wisc.edu
authors.forename: G G
authors.initials: GG
authors.lastname: Borisy
authors.forename: T M
authors.initials: TM
authors.lastname: Svitkina
mesh_terms: D051339:Actin Depolymerizing Factors; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000378:metabolism*; D000818:Animals; D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D003712:Dendrites / Q000378:metabolism; D051345:Destrin; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D051304:Profilins
chemical_list: C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051339:Actin Depolymerizing Factors; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D003285:Contractile Proteins; D003598:Cytoskeletal Proteins; D051345:Destrin; D008840:Microfilament Proteins; D020409:Molecular Motor Proteins; C495738:PFN1 protein, human; D051304:Profilins