Mechanisms of selective neuronal cell death due to thiamine deficiency.
Multiple mechanisms contribute to the selective brain lesions observed in WKS and experimental thiamine deficiency. Recent evidence of early microglial activation and increased free radical production suggest that oxidative stress processes play an important early role in the brain damage associated with thiamine deficiency.
Todd
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K
Neuroscience Research Unit, Centre Hospitalier de l'Université de Montréal, Québec, Canada. kgtodd@ualberta.ca
Butterworth
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RF
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D016923:Cell Death; D006801:Humans; D020915:Korsakoff Syndrome / Q000473:pathology*; D017628:Microglia / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000473:pathology* / Q000502:physiology; D011745:Pyrithiamine; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013832:Thiamine Deficiency / Q000473:pathology* / Q000503:physiopathology
D016194:Receptors, N-Methyl-D-Aspartate; D011745:Pyrithiamine