Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice.
The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.
Abraham
R S
RS
Department of Immunology, Mayo Medical School, Rochester, MN-55905, USA. abraham.roshini@mayo.edu
David
C S
CS
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D005802:Genes, MHC Class II; D006681:HLA-D Antigens / Q000235:genetics*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009103:Multiple Sclerosis / Q000276:immunology
D001324:Autoantigens; D006681:HLA-D Antigens