[Antiepileptic effects of nimodipine on penicillin-induced seizures in rats].
Injecting penicillin (PNC) intraperitoneally in Wistar rats, we observed their epileptic behaviour and electroencephalographys. The results showed that nimodipine (NIM), a calcium antagonist, could inhibit the seizures and epileptic discharges significantly. No epileptic action was noted while NIM was injected before PNC. It supports our consideration of NIM as a new sort of nonsedative anticonvulsant in clinical practice.
Zou
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X
Department of Neurology, First Affiliated Hospital, Chengdu.
Ruan
X
X
Zhou
S
S
Cai
Q
Q
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D010406:Penicillins; D051381:Rats; D017208:Rats, Wistar
D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D010406:Penicillins; D009553:Nimodipine