Coccidioidomycosis in pregnancy during an epidemic in California.
OBJECTIVE
To determine presentation, clinical course, and outcome of a cohort of pregnant women with coccidioidomycosis and compare findings with common observations reported in the literature.


METHODS
Thirty-two women who delivered live infants or aborted fetuses in 1993 and had confirmed diagnoses of coccidioidomycosis were included in the study. Medical records were evaluated retrospectively for clinical characteristics, laboratory results, and disease course.


RESULTS
Dissemination occurred in three of 32 cases. The most common management was supportive and symptomatic care. At 1 year, 26 of 32 had recovered. There were no maternal deaths.


CONCLUSIONS
The common depiction of coccidioidomycosis in pregnancy has overstated morbidity and mortality likely because of reporting bias. Many women will have favorable outcomes without drug treatment, and the practice of abortions or early delivery in subjects with active infection should be rare.
Caldwell
J W
JW
Kern Medical Center, Department of Internal Medicine, Bakersfield, California 93305, USA. caldwelj@kernmedctr.com
Arsura
E L
EL
Kilgore
W B
WB
Garcia
A L
AL
Reddy
V
V
Johnson
R H
RH
D000328:Adult; D002140:California / Q000453:epidemiology; D003047:Coccidioidomycosis / Q000453:epidemiology*; D015331:Cohort Studies; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D008499:Medical Records; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies