title: Dynamic MR imaging of mandibular osteoradionecrosis.
abstract: OBJECTIVE
  Osteoradionecrotic bone has been characterised as hypovascular and metabolically inactive tissue with impaired perfusion. The present study was conducted to determine if dynamic contrast-enhanced MR imaging could provide additional information about the vascularity of radionecrotic mandibular bone.
  
  
  METHODS
  Dynamic contrast-enhanced MR imaging was performed on 10 patients with mandibular osteoradionecrosis (ORN), and on 6 patients, irradiated for oropharyngeal tumours, without symptoms or signs of ORN. Nine patients in the ORN group received a series of 20 hyperbaric oxygen (HBO) treatments, after which the dynamic MR investigation was repeated.
  
  
  CONCLUSIONS
  Radiation per se did not lead to increased contrast enhancement, whereas all patients with ORN showed marked contrast enhancement of the osteoradionecrotic bone marrow. After HBO treatment, pathological contrast enhancement of the abnormal bone marrow could still be seen, but the rate of enhancement was less than before in 7 of 9 patients. Two patients had an increase in the enhancement rate. The findings suggest the existence of an increased and patent microvasculature.
authors.affiliation: Department of Maxillo-Facial Surgery, National Hospital, Oslo, Norway.
authors.forename: G
authors.initials: G
authors.lastname: Støre
authors.forename: H J
authors.initials: HJ
authors.lastname: Smith
authors.forename: T A
authors.initials: TA
authors.lastname: Larheim
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008334:Mandible / Q000473:pathology; D008336:Mandibular Diseases / Q000175:diagnosis*; D008875:Middle Aged; D010025:Osteoradionecrosis / Q000175:diagnosis*; D010039:Otorhinolaryngologic Neoplasms / Q000532:radiotherapy
chemical_list: D003287:Contrast Media