title: Recurrence following curative resection for gastric carcinoma.
abstract: BACKGROUND
  The diagnosis and treatment of recurrent gastric cancer remains difficult. The aim of this study was to determine the risk factors for recurrence of gastric cancer and the prognosis for these patients.
  
  
  METHODS
  Of 2328 patients who underwent curative resection for gastric cancer from 1987 to 1995, 508 whose recurrence was confirmed by clinical examination or reoperation were studied retrospectively. The risk factors that determined the recurrence patterns and timing were investigated by univariate and multivariate analysis.
  
  
  RESULTS
  The mean time to recurrence was 21.8 months and peritoneal recurrence was the most frequent (45.9 per cent). Logistic regression analysis showed that serosal invasion and lymph node metastasis were risk factors for all recurrence patterns and early recurrence (at 24 months or less). In addition, independent risk factors involved in each recurrence pattern included younger age, infiltrative or diffuse type, undifferentiated tumour and total gastrectomy for peritoneal recurrence; older age and larger tumour size for disseminated, haematogenous recurrence; and older age, larger tumour size, infiltrative or diffuse type, proximally located tumour and subtotal gastrectomy for locoregional recurrence. Other risk factors for early recurrence were infiltrative or diffuse type and total gastrectomy. Reoperation for cure was possible in only 19 patients and the mean survival time after conservative treatment or palliative operation was less than 12 months.
  
  
  CONCLUSIONS
  The risk factors for each recurrence pattern and timing of gastric cancer can be predicted by the clinicopathological features of the primary tumour. Since the results of treatment remain dismal, studies of perioperative adjuvant therapy in an attempt to reduce recurrence are warranted.
authors.affiliation: Department of Surgery, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-ku, 120-752, Seoul, Korea.
authors.forename: C H
authors.initials: CH
authors.lastname: Yoo
authors.forename: S H
authors.initials: SH
authors.lastname: Noh
authors.forename: D W
authors.initials: DW
authors.lastname: Shin
authors.forename: S H
authors.initials: SH
authors.lastname: Choi
authors.forename: J S
authors.initials: JS
authors.lastname: Min
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D012086:Reoperation; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000601:surgery*; D016019:Survival Analysis; D013997:Time Factors