Protective effect of ellagic acid on t-butyl hydroperoxide induced lipid peroxidation in isolated rat hepatocytes.
Ellagic acid, a plant polyphenol, showed protective effect on isolated rat hepatocytes against destruction due to lipid peroxide formation induced by t-butyl hydroperoxide in vitro. Ellagic acid inhibited the generation of superoxide anions and hydroxyl radicals both in enzymic and non enzymic systems, thus providing protection against oxidative damage.
Singh
K
K
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Khanna
A K
AK
Visen
P K
PK
Chander
R
R
D000818:Animals; D002478:Cells, Cultured; D004610:Ellagic Acid / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D020122:tert-Butylhydroperoxide / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D004610:Ellagic Acid; D020122:tert-Butylhydroperoxide