Do cytoskeletal components control fatty acid translocation into liver mitochondria?
For two decades it has been assumed that inhibition of carnitine palmitoyltransferase I (CPT-I) by malonyl-CoA represents the main regulatory mechanism of liver ketogenesis. However, recent evidence indicates that CPT-I activity is also controlled by interactions between mitochondria and cytoskeletal components. This newly recognized mechanism emphasizes the emerging role of the cytoskeleton in the regulation of metabolic pathways.
Guzmán
M
M
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040-Madrid, Spain.
Velasco
G
G
Geelen
M J
MJ
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002334:Carnitine O-Palmitoyltransferase / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D008316:Malonyl Coenzyme A / Q000502:physiology; D008930:Mitochondria, Liver / Q000378:metabolism*
D005227:Fatty Acids; D008316:Malonyl Coenzyme A; D002334:Carnitine O-Palmitoyltransferase