Influence of dietary phosphorus depletion on central pathways of intermediary metabolism in rats.
Studies on P depleted rats compared with control animals kept under pair fed conditions were carried out. Dietary P depletion led to reduced weight gain and a decreased food conversion ratio in comparison with pair fed control animals. Higher N retention, higher urea concentrations in plasma, liver and kidney tissues and a significant reduction of renal glutamate dehydrogenase--a central enzyme of amino acid degradation in kidney mitochondria--in P depleted animals indicated changes in N utilization and N excretion. While lipid metabolism was not affected by P depletion, carbohydrate metabolism was substantially changed in the kidney: Activity of fructose diphosphatase was significantly reduced, implicating a reduced gluconeogenesis in P depletion. Possible mechanisms of these metabolic effects in P depletion are discussed.
Huber
K
K
Department of Physiology, School of Veterinary Medicine, Hannover, Germany. khuber@win.tiho-hannover.de
Breves
G
G
D000818:Animals; D002118:Calcium / Q000378:metabolism; D050260:Carbohydrate Metabolism; D004435:Eating; D007668:Kidney / Q000201:enzymology; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D009584:Nitrogen / Q000378:metabolism*; D010758:Phosphorus / Q000172:deficiency* / Q000378:metabolism; D016226:Phosphorus, Dietary / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar / Q000254:growth & development / Q000378:metabolism*; D015430:Weight Gain
D016226:Phosphorus, Dietary; D010758:Phosphorus; D009584:Nitrogen; D002118:Calcium