Finding the genes that direct mammalian development : ENU mutagenesis in the mouse.
The genetic control of mammalian embryogenesis is not well understood. N-ethyl-N-nitrosourea (ENU) mutagenesis screens in the mouse provide a route to identify more of the genes that are required for mammalian development. The characterization of ENU-induced mutations can build on the resources provided by the mouse and human genome projects to help define the tissue interactions and signaling pathways that direct early mammalian development.
Anderson
K V
KV
Molecular Biology Program, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10021, USA. k-anderson@ski.mskcc.org
D000818:Animals; D002874:Chromosome Mapping; D000013:Congenital Abnormalities / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005038:Ethylnitrosourea / Q000633:toxicity*; D018507:Gene Expression Regulation, Developmental; D005796:Genes; D005820:Genetic Testing; D006801:Humans; D008322:Mammals / Q000235:genetics*; D051379:Mice / Q000235:genetics*; D008817:Mice, Mutant Strains; D016296:Mutagenesis; D013045:Species Specificity
D005038:Ethylnitrosourea