Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue.
This study quantifies the spatial distribution of pO2 in glioma and in the surrounding brain tissue. Both glioma and peritumoural brain contain regions at oxygen tensions less than 2.5 mmHg. Modalities targeting hypoxia to improve the efficacy of therapy may have an important role in the management of this disease.
Collingridge
D R
DR
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06520-8040, USA.
Piepmeier
J M
JM
Rockwell
S
S
Knisely
J P
JP
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001923:Brain Chemistry; D001932:Brain Neoplasms / Q000378:metabolism*; D016292:Procedural Sedation; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis* / Q000097:blood; D010313:Partial Pressure; D011048:Polarography
D010100:Oxygen