Meropenem alone and in combination with vancomycin in experimental meningitis caused by a penicillin-resistant pneumococcal strain.
In a rabbit model of meningitis caused by a pneumococcus highly resistant to penicillin (MIC, 4 microg/ml), meropenem, a broad-spectrum carbapenem, was bactericidal (-0.48+/-0.14 deltalog10 cfu/ml h) and slightly superior to ceftriaxone (-0.34+/-0.23 deltalog10 cfu/ml x h) and vancomycin (-0.39+/-0.19 deltalog10 cfu/ml x h). Although the combination of vancomycin with ceftriaxone was significantly more active than ceftriaxone alone (-0.55+/-0.19 deltalog10 cfu/ml x h), only an insignificant gain was observed by the addition of vancomycin to meropenem (-0.55+/-0.28 deltalog10 cfu/ml x h).
Gerber
C M
CM
Department of Internal Medicine, Inselspital, Berne, Switzerland.
Cottagnoud
M
M
Neftel
K A
KA
Täuber
M G
MG
Cottagnoud
P
P
D000818:Animals; D002443:Ceftriaxone / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use; D002511:Cephalosporins / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use*; D008586:Meningitis, Pneumococcal / Q000188:drug therapy* / Q000382:microbiology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D013845:Thienamycins / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use*; D014640:Vancomycin / Q000134:cerebrospinal fluid / Q000494:pharmacology / Q000627:therapeutic use*
D002511:Cephalosporins; D013845:Thienamycins; D014640:Vancomycin; D002443:Ceftriaxone; D000077731:Meropenem