[Dependence of the pump function of the isolated rat heart on the functional activity of sigma receptors during reperfusion].
Pre-treatment of the sigma-receptor with the sigma-receptor agonist (+)-SKF 10.047 improved the reperfusion recovery of cardiac pump function. The sigma-receptor activation, among other effects, prevented the reperfusion contracture, increased pressure in the left ventricle, and improved survival of cardiomyocytes after ischemia/reperfusion. Pre-treatment with the sigma-receptor antagonist DuP 734 augmented the reperfusion systolic dysfunction of the myocardium and prevented postischemic contractures and cardiac cell lesions. Activation of the cardiac sigma-receptor seems to prompt an augmentation of tolerance to the reperfusion damage.
Maslov
L N
LN
Research Institute of Cardiology of the Russian Acad. Med. Sci., Siberian Branch, Tomsk, Russia.
Lishmanov
Iu B
IuB
Bogomaz
S A
SA
Gilligan
P
P
Tam
S W
SW
D000818:Animals; D001794:Blood Pressure; D003402:Creatine Kinase / Q000378:metabolism; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D010620:Phenazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D016277:Ventricular Function, Left / Q000187:drug effects; D017725:Ventricular Pressure / Q000187:drug effects
D010880:Piperidines; D017480:Receptors, sigma; C012134:SK&F 10047; C078773:DuP 734; D003402:Creatine Kinase; D010620:Phenazocine