[Study on the joint action of selenium and cadmium on DNA damage of rat liver cells].
The effect of joint action of selenium and cadmium on DNA damage in rat liver cells was investigated with single cell gel electrophoresis. The results show that both selenium and cadmium can induce DNA damage at the concentration of 8.75 mumol/L, 17.5 mumol/L and 35 mumol/L. The degree of DNA damage induced by cadmium is more serious than by selenium. When selenium and cadmium act jointly, they can antagonize each other on DNA damage at the concentration of 8.75 mumol/L and 17.5 mumol/L, but not at the concentration of 35 mumol/L. There is an antagonism between selenium and cadmium on DNA damage in rat liver cells at certain concentrations.
Yu
R A
RA
Department of Environmental Health, Tongji Medical University, Wuhan, China.
Chen
X
X
D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors*; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects*; D008099:Liver / Q000166:cytology*; D008297:Male; D051381:Rats; D012643:Selenium / Q000494:pharmacology*
D002104:Cadmium; D012643:Selenium