Developmental toxicity of 2-ethylhexyl stearate.
2-Ethylhexyl stearate was investigated in an embryo-/foetotoxicity and teratogenicity study on rats according to OECD guidelines for the testing of chemicals (No. 414). Dose levels of 0 (arachidis oil), 100, 300 and 1000mg/kg body weight/day were administered by gavage. Dams tolerated the applied dose levels without any toxic effects. Pre- and post-implantation loss and mean numbers of resorptions were unaffected by treatment. All parameters were comparable with the animals of the control group. Skeletal and visceral investigations revealed no treatment-related malformations. For embryo-/foetotoxicity, teratogenicity and maternal toxicity a NOAEL of 1000mg/kg was deduced.
Aulmann
W
W
Henkel KGaA, D-40191, Düsseldorf, Germany. Walter.Aulmann@Henkel.de
Pittermann
W
W
Bartnik
F
F
Sterzel
W
W
Kästner
W
W
Potokar
M
M
D000014:Abnormalities, Drug-Induced / Q000503:physiopathology* / Q000662:veterinary; D000818:Animals; D002208:Caproates / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013229:Stearic Acids / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*
D002208:Caproates; D013229:Stearic Acids; D013723:Teratogens; C040668:2-ethylhexanoic acid