A new benzoangelicin with strong photobiological activity.
Benzoangelicins 4-6 were synthesized in good yields from 7-hydroxy-5-methoxy-4-methylcoumarin (1). In the absence of UVA radiation, compounds 5 and 6 were only weakly active against HL60 and HeLa tumour cells; in its presence, compound 6 was 10 times more active than the reference compound 8-methoxypsoralen. None of 4-6 exhibited cutaneous phototoxicity.
Santana
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L
Laboratorio de Química Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Uriarte
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E
Dalla Via
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L
Gia
O
O
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000378:metabolism; D018922:HL-60 Cells / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008730:Methoxsalen / Q000494:pharmacology; D015394:Molecular Structure; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D014466:Ultraviolet Rays
C404723:5-(N,N-dimethylaminopropoxy)-4-methylbenzofuro(1,2-h)benzopyran-2-one; D000970:Antineoplastic Agents; D001572:Benzofurans; D003374:Coumarins; D017319:Photosensitizing Agents; D004247:DNA; D008730:Methoxsalen