[Pretreatment with monoclonal antibody anti-CD18 prevents the trans-cellular biosynthesis of sulfidopeptide-leukotrienes in vitro and in vivo and protects from the subsequent functional changes in the isolated rabbit heart].
Sala
A
A
Centro di Farmacologia, Università degli Studi, Milano.
Rossoni
G
G
Berti
F
F
Buccellati
C
C
Bonazzi
A
A
Maclouf
J
J
Folco
G
G
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D018821:CD18 Antigens / Q000276:immunology*; D003545:Cysteine / Q000096:biosynthesis*; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000378:metabolism*; D015289:Leukotrienes / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism*; D011292:Premedication; D011817:Rabbits
D000911:Antibodies, Monoclonal; D018821:CD18 Antigens; D018836:Inflammation Mediators; D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D003545:Cysteine