Protein folding: Thickening the broth.
Recent results support the notion that macromolecular 'crowding' enhances protein aggregation, at the expense of correct folding. The results can be rationalised in terms of kinetic competition between distinct processes, taking into account the relative influence of crowding on each process.
Minton
A P
AP
Building 8, Room 226, NIH, Bethesda, 20892-0830, USA. minton@helix.nih.gov
D046911:Macromolecular Substances; D017510:Protein Folding; D020673:Protein Renaturation; D011506:Proteins / Q000737:chemistry*
D046911:Macromolecular Substances; D011506:Proteins