[Study on the antagonistic action of selenite on fluoride-induced lipid peroxidation and on the changes of trace elements in rats].
Five groups of SD male rats were provided with deionized drinking water containing 0 and 150 mg/L NaF, and containing both 150 mg/L NaF and 0.5, 2.0 or 4.0 mg/L Na2SeO3 respectively for 10 weeks, in order to find out the optimal level of selenite in drinking water against fluoride toxicity. The results showed that fluoride could cause significant increase of lipid peroxides (LPO) and metabolic disorder of trace elements in the serum and kidney of rats. The antagonistic effect of 2.0 mg/L Na2SeO3 drinking water on the lipid peroxidation induced by 150 mg/LNaF was the most evident, whereas those of 0.5 and 4.0 mg/L Na2SeO3 were not obvious. It is concluded that selenite possesses significant antagonistic effects on renal damages induced by fluoride and 2.0 mg/L Na2SeO3 is the optimal concentration for the antagonistic effect on renal impairments induced by 150 mg/L NaF in drinking water.
Yang
K
K
Department of Environmental Health, Tongji Medical University, Wuhan, China.
Chen
J
J
Wang
G
G
Liu
S
S
D000818:Animals; D003300:Copper / Q000378:metabolism; D005459:Fluorides / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D018038:Sodium Selenite / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism*
D003300:Copper; D018038:Sodium Selenite; D015032:Zinc; D005459:Fluorides