title: [Bcl-2 mRNA expression in acute promyelocytic leukemia by RT-PCR].
abstract: To check the anti-apoptosis gene bcl-2 mRNA expression in 20 APL patients by PCR, and analyse the relationship between bcl-2 mRNA and the PML-RARa isoform. The result is that the bcl-2 mRNA expression has no significance between the isoforms (P > 0.05). This shows that the PML-RARa transcription type has no influence on the clinical features and prognosis.
authors.affiliation: Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: Z
authors.initials: Z
authors.lastname: Qi
authors.forename: Z
authors.initials: Z
authors.lastname: Jian
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015870:Gene Expression; D019254:Genes, bcl-2; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger