The use of a hydrophobic matrix for the sustained release of a highly water soluble drug.
An experimental investigation into the use of a hydrophobic matrix to control the release of a highly water soluble drug was undertaken. Matrices consisting of hydrogenated vegetable oil and calcium sulfate with a 4% drug loading showed a sustained-release profile of up to 24 hr. The release mechanism from such matrices seemed to obey both root time kinetics and first-order behavior. Investigations showed that the effect of geometry had a significant effect on the drug release rate.
Martini
L G
LG
Smithkline Beecham Pharmaceuticals, Pharmaceutical Technologies Department, Harlow, Essex, United Kingdom.
Coles
M
M
Gravell
K
K
Stephenson
S
S
Thomson
C M
CM
D000465:Algorithms; D002133:Calcium Sulfate / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D005079:Excipients / Q000737:chemistry*; D010938:Plant Oils; D012995:Solubility; D013607:Tablets
D003692:Delayed-Action Preparations; D005079:Excipients; D010938:Plant Oils; D013607:Tablets; D002133:Calcium Sulfate