title: Pediatric thyroid carcinoma: 22 years of experience at the Northern Israel Oncology Center (1973-1995).
abstract: Over the past 22 years, 16 children with thyroid carcinoma were referred to the Northern Israel Oncology Center. All patients had undergone surgical procedures, either total or subtotal thyroidectomy, and 7 patients had undergone cervical lymph node dissections. Postoperatively, 5 patients underwent thyroid ablation with radioactive 131I as first treatment. Two patients received postoperative external radiation therapy to a field encompassing the cervical region, superior mediastinum, and both supraclavicular grooves. After a median follow-up of 60 months (range, 5-169 months), all patients are alive with no evidence of recurrent disease. Two patients who had recurrences, one in the submaxillary lymph nodes and one in the lungs, were salvaged successfully with retreatment with 131I therapy. No severe acute or long-term side effects were exhibited. The long-term results of treatment of pediatric thyroid carcinoma are excellent, but there remains disagreement over the extent of surgical and postsurgical treatment required.
authors.affiliation: Department of Pediatric Hematology-Oncology, Rambam Medical Center, Haifa, Israel.
authors.forename: M W
authors.initials: MW
authors.lastname: Ben Arush
authors.forename: M E
authors.initials: ME
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Perez Nahum
authors.forename: J
authors.initials: J
authors.lastname: Zidan
authors.forename: A
authors.initials: A
authors.lastname: Kuten
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013964:Thyroid Neoplasms / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome