title: Treatment of dementia-associated agitation with gabapentin.
abstract: The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral management of patients with dementia.
authors.affiliation: Department of Psychiatry and the Neurobehavior and Alzheimer's Disease Center, Beth Israel Medical Center, New York, NY 10003, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Roane
authors.forename: T E
authors.initials: TE
authors.lastname: Feinberg
authors.forename: L
authors.initials: L
authors.lastname: Meckler
authors.forename: C R
authors.initials: CR
authors.lastname: Miner
authors.forename: A
authors.initials: A
authors.lastname: Scicutella
authors.forename: R N
authors.initials: RN
authors.lastname: Rosenthal
mesh_terms: D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy*; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D015161:Dementia, Multi-Infarct / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009460:Neurologic Examination / Q000187:drug effects; D011595:Psychomotor Agitation / Q000175:diagnosis / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin