[Detection of interleukin-2 receptor in patients with idiopathic thrombocytopenic purpura].
Using ELISA and indirect fluorescent antibody techniques(IFAT), the serum soluble inter-leukin-2 receptor(sIL-2R) and membrane IL-2R (mIL-2R) on lymphocyte cells induced by phyto-hemagglutinin (PHA) were studied in patients with idiopathic thrombocytopenic purpura (ITP). The results showed that the level of sIL-2R increased significantly before treatment and decreased after treatment; the percentages of mIL-2R induced by PHA decreased. There was no correlation between the level of serum sIL-2R and that of mIL-2R. Our observations suggest that increased level of serum sIL-2R in ITP patients may be one of causes evoking cellular immunological abnormalities.
Tan
B
B
Department of Hematology Xiagya Hospital, Changsha.
Zhao
X
X
Yin
C
C
D000293:Adolescent; D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000097:blood*
D005938:Glucocorticoids; D015375:Receptors, Interleukin-2