Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view.
A broad range of studies has established that heat shock proteins (Hsps) potentially play a role in tumor immunosurveillance. Here, Andrew Wells and Miroslav Malkovsky highlight recent data that demonstrate a causal relationship between the expression of Hsps and tumor immunogenicity, and suggest several mechanisms by which Hsps might influence the capacity of a tumor to induce an immune response.
Wells
A D
AD
Dept of Medicine, University of Pennsylvania, USA. adwells@mail.med.upenn.edu
Malkovsky
M
M
D000818:Animals; D017951:Antigen Presentation; D006360:Heat-Shock Proteins / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000276:immunology*
D006360:Heat-Shock Proteins