title: Involvement of carbon monoxide in the innervation of the canine cervical esophagus and trachea.
abstract: We investigated the involvement of carbon monoxide (CO) in the innervation of the canine cervical esophagus and trachea by means of immunohistochemistry using an antiserum against heme oxygenase-2 (HO-2). We detected HO-2-immunoreactive nerve fibers around the blood vessels and submucosal glands of the esophagus and trachea. We found HO-2-immunoreactive neurons in ganglia in the trachea and in the myenteric plexus of the esophagus. These results suggest that CO is involved as a neurotransmitter in the innervation of the canine esophagus and trachea.
authors.affiliation: Department of Otolaryngology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hisa
authors.forename: S
authors.initials: S
authors.lastname: Koike
authors.forename: H
authors.initials: H
authors.lastname: Bamba
authors.forename: K
authors.initials: K
authors.lastname: Shogaki
authors.forename: N
authors.initials: N
authors.lastname: Tadaki
authors.forename: T
authors.initials: T
authors.lastname: Uno
mesh_terms: D000818:Animals; D002248:Carbon Monoxide / Q000502:physiology*; D004285:Dogs; D004947:Esophagus / Q000294:innervation*; D006419:Heme Oxygenase (Decyclizing) / Q000032:analysis; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000737:chemistry; D018377:Neurotransmitter Agents / Q000502:physiology*; D014132:Trachea / Q000294:innervation*
chemical_list: D018377:Neurotransmitter Agents; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)