Cloak and dagger in the avoidance of immune surveillance.
CD95 and CD95-ligand (CD95L) are physiological mediators of apoptosis required for the control of cell numbers in the human immune system. Discoveries in CD95-dependent mechanisms of immune evasion by tumours suggest regulation by oncogene expression. Clonal contraction of lymphocytes by a CD95/CD95L-independent mechanism has been reported and new evidence supports a role for CD95-dependent peripheral lymphocyte deletion by non-lymphoid tissue. Additionally, factors affecting the pro- and anti-inflammatory effects of CD95L point to a balance of cytokines and growth factors.
Pinkoski
M J
MJ
La Jolla Institute for Allergy & Immunology, San Diego, California 92121, USA. michael@liai.org
Green
D R
DR
D017209:Apoptosis / Q000276:immunology*; D053222:Fas Ligand Protein; D006801:Humans; D007157:Immunologic Surveillance / Q000235:genetics*; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008562:Membrane Glycoproteins / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor