Tyrosine kinase SYK: essential functions for immunoreceptor signalling.
The tyrosine kinase SYK plays critical roles in signalling through immune receptors. Gene-targeting studies have identified the cell types that require SYK for development and function, and the receptors that use SYK as well as their downstream signalling effectors. There is also evidence of a role for SYK in non-immune cells and in the maintenance of vascular integrity.
Turner
M
M
Molecular Immunology Programme, The Babraham Institute, Cambridge, UK CB2 4AT. martin.turner@bbsrc.ac.uk
Schweighoffer
E
E
Colucci
F
F
Di Santo
J P
JP
Tybulewicz
V L
VL
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D004792:Enzyme Precursors / Q000276:immunology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000276:immunology*; D011961:Receptors, Fc / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction; D000072377:Syk Kinase; D016176:T-Lymphocyte Subsets / Q000276:immunology; D051746:ZAP-70 Protein-Tyrosine Kinase
D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D011961:Receptors, Fc; D011971:Receptors, Immunologic; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase; C497261:ZAP70 protein, human