title: Linkage study of two polymorphisms at the dopamine D3 receptor gene and attention-deficit hyperactivity disorder.
abstract: Data from animal studies suggest that the dopamine D3 receptor gene may have a role in locomotion and behavioral regulation. Therefore, this gene has been suggested as a candidate for attention-deficit hyperactivity disorder (ADHD). The dopamine D3 receptor gene (DRD3) has two common polymorphisms, one in exon I that changes a Serine to Glycine (Ser9Gly) and alters the recognition site for the restriction enzyme MscI [Lannfelt et al., 1992]. The other common polymorphism is located in intron 5 and results in the change of a restriction site for MspI [Griffon et al., 1996]. We investigated the possibility of linkage of the dopamine D3 receptor gene in 100 small, nuclear families consisting of a proband with ADHD, their parents, and affected siblings. We examined the transmission of the alleles of each of these polymorphisms and the haplotypes of both polymorphisms using the transmission disequilibrium test [Spielman et al., 1993]. We did not observe biased transmission of the alleles at either polymorphism or any haplotype. Our findings using this particular sample do not support the role of the dopamine D3 gene in ADHD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:114-117, 2000.
authors.affiliation: Department of Psychiatry, The Toronto Hospital, Western Division, Toronto, Ontario, Canada. CBarr@playfair.utoronto.ca
authors.forename: C L
authors.initials: CL
authors.lastname: Barr
authors.forename: K G
authors.initials: KG
authors.lastname: Wigg
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Zai
authors.forename: S
authors.initials: S
authors.lastname: Bloom
authors.forename: R
authors.initials: R
authors.lastname: Tannock
authors.forename: W
authors.initials: W
authors.lastname: Roberts
authors.forename: M
authors.initials: M
authors.lastname: Malone
authors.forename: R
authors.initials: R
authors.lastname: Schachar
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D008040:Genetic Linkage; D006239:Haplotypes; D006801:Humans; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3
chemical_list: C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3