Clinicopathological study of recurrent uterine cervical squamous-cell carcinoma.
OBJECTIVE
To improve prognoses of patients with recurrent uterine cervical squamous-cell carcinoma.


METHODS
We clinicopathologically analyzed 464 patients with uterine cervical squamous-cell carcinoma (126 positive, 338 negative pelvic lymph-node metastasis) who were treated at the Saitama Cancer Center from January 1, 1976 to December 31, 1991.


RESULTS
The recurrence rates of negative pelvic lymph-node metastasis patients were 14. 2% (39/274) in pT1b and 32.8% (21/64) in pT2b. But for positive lymph-node metastasis patients the rates were 39.0% (23/59) in pT1b and 58.2% (39/67) in pT2b. The interval to recurrence was shorter in positive pelvic lymph-node patients than in negative patients. The 5-year survival rates after relapse of negative lymph-node patients with intrapelvic, extrapelvic, and both-sites recurrence were 53, 12, and 40%, respectively. But among distant recurrent sites, lung metastasis in negative lymph-node patients and lymphatic tract metastasis brought relatively fair prognoses.


CONCLUSIONS
Regular long-term checks are necessary and active retreatments are recommended for patients with local recurrences, lung metastasis, or lymphatic vessel metastatic lesions.
Shiromizu
K
K
Division of Gynecology, Saitama Cancer Center, Japan.
Kasamatsu
T
T
Honma
T
T
Matsumoto
K
K
Shirai
T
T
Takahashi
M
M
D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000556:secondary; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000556:secondary; D011379:Prognosis; D012878:Skin Neoplasms / Q000401:mortality / Q000556:secondary; D002583:Uterine Cervical Neoplasms / Q000401:mortality* / Q000473:pathology