Antithrombotic activity of the superoxide dismutase-chondroitin sulfate complexes in a rat model of arterial injury.
Individual antithrombotic activities of superoxide dismutase (SOD) and sodium chondroitin sulfate (CHS) as well as the activities of covalent and noncovalent complexes of SOD with CHS were compared in a rat model of arterial thrombosis induced by ferrous chloride. Covalent conjugate of SOD with CHS exerted the most potent antithrombotic effect, which was associated with adsorption of the conjugate on the glycocalyx of the vascular wall cells and stability of the covalent bond between CHS and SOD subunits. Theoretical and practical directions in the investigation of SOD and CHS preparations are outlined.
Maksimenko
A V
AV
Institute of Experimental Cardiology, Russian Cardiology Research Center, Moscow, Russia.
Tischenko
E G
EG
Golubykh
V L
VL
D000818:Animals; D002339:Carotid Arteries / Q000473:pathology; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004355:Drug Stability; D005296:Ferrous Compounds; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D019276:Glycocalyx / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D013927:Thrombosis / Q000139:chemically induced / Q000188:drug therapy*
D004338:Drug Combinations; D005296:Ferrous Compounds; D005343:Fibrinolytic Agents; D002809:Chondroitin Sulfates; D013482:Superoxide Dismutase; C029451:ferrous chloride