title: Use of detomidine hydrochloride as an adjunct for studying first-stage Gasterophilus intestinalis (Diptera: Gasterophilidae) in the tongue of the horse.
abstract: A synthetic alpha-2 adrenergic agonist, detomidine hydrochloride, was used in the study of in vivo activity of Gasterophilus intestinalis (Diptera: Gasterophilidae) during migration in the tongue of the horse. Use of the drug allowed the investigator to manipulate the tongue and closely observe the movement patterns and tissue disturbance caused by burrowing first-stage larvae. Detomidine hydrochloride should be utilized in studies of drug efficacy and larval biology, whenever possible, to avoid the need to sacrifice the horse.
authors.affiliation: vetstudies@aol.com
authors.forename: T P
authors.initials: TP
authors.lastname: Cogley
authors.forename: M C
authors.initials: MC
authors.lastname: Cogley
mesh_terms: D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D004175:Diptera / Q000502:physiology*; D006734:Horse Diseases / Q000469:parasitology*; D006736:Horses; D007093:Imidazoles / Q000008:administration & dosage; D009198:Myiasis / Q000469:parasitology / Q000662:veterinary*; D014059:Tongue / Q000469:parasitology*
chemical_list: D000700:Analgesics; D007093:Imidazoles; C041255:detomidine