Prognostic significance of increased IL-10 production in patients prior to allogeneic bone marrow transplantation.
IL-10 is a potent immunosuppressant which inhibits allo-antigen-specific T cell responses. In addition, IL-10 is a strong endogenous anti-inflammatory cytokine. To investigate the role of IL-10 in the induction of acute GVHD following allogeneic bone marrow transplantation (BMT) we performed a prospective study on spontaneous IL-10 production by peripheral blood mononuclear cells (PBMNC) in 84 patients admitted for allogeneic BMT. High spontaneous IL-10 production by PBMNC at the time of admission and prior to any preparative treatment correlated with a subsequent low incidence of GVHD and transplant-related mortality (8%), as compared to patients with low or intermediate IL-10 production (50%, P < 0. 01). Our data demonstrate the prognostic significance of increased IL-10 production in BMT patients and suggest a major role of IL-10 in maintaining immunobalance in the setting of allogeneic BMT. Bone Marrow Transplantation (2000) 25, 237-241.
Holler
E
E
Department of Hematology and Oncology, University of Regensburg, Germany.
Roncarolo
M G
MG
Hintermeier-Knabe
R
R
Eissner
G
G
Ertl
B
B
Schulz
U
U
Knabe
H
H
Kolb
H J
HJ
Andreesen
R
R
Wilmanns
W
W
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D018929:Cell Culture Techniques; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000097:blood / Q000494:pharmacology*; D007938:Leukemia / Q000097:blood / Q000378:metabolism / Q000628:therapy; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D014184:Transplantation, Homologous
D016753:Interleukin-10