Mood state and brain electric activity in ecstasy users.
Resting EEG during open and closed eyes and subsequent mood ratings were obtained from 15 Ecstasy users and 14 Ecstasy-naive controls. Absolute spectral power on the scalp, and the three-dimensional, intracerebral distribution of neuroelectric activity using low resolution brain electromagnetic tomography (LORETA) were computed. LORETA revealed global increases of theta, alpha 1 and beta 2/3 power during eyes open in Ecstasy users, and spectral analyses revealed a right-posterior increase of alpha 2 power (confirmed by LORETA) and increased beta band activity during open eyes. Ecstasy users had higher levels of state depressiveness, emotional excitability and a trend-level increase in state anxiety. The observed differences may be related to regular exposure to Ecstasy or other illicit drugs, or may be pre-existing.
Gamma
A
A
KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland.
Frei
E
E
Lehmann
D
D
Pascual-Marqui
R D
RD
Hell
D
D
Vollenweider
F X
FX
D000328:Adult; D000339:Affect / Q000187:drug effects*; D001007:Anxiety / Q000139:chemically induced / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006213:Hallucinogens / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects / Q000494:pharmacology*; D014054:Tomography
D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine