Extrinsic regulators of epithelial tumor progression: metalloproteinases.
Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.
Bergers
G
G
Hormone Research Institute, University of California, 1090 HSW Box 0534, San Francisco, California 94143, USA. bergers@cgl.ucsf.edu.
Coussens
L M
LM
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D019278:Matrix Metalloproteinase 3 / Q000378:metabolism; D008666:Metalloendopeptidases / Q000378:metabolism*; D009375:Neoplasms, Glandular and Epithelial / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D009857:Oncogenes
D015815:Cell Adhesion Molecules; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3; C028220:Crotalus adamanteus proteinase II