title: Tissue factor in human coronary atherosclerotic plaques.
abstract: The rupture or fissuring of a coronary atherosclerotic plaque and subsequent thrombosis is considered the key event in the pathogenesis of unstable angina and myocardial infarction. Although plaque disruption frequently occurs during the evolution of atherosclerosis, only a minority of ruptured plaques develop thrombosis. The content and procoagulant activity of tissue factor in human coronary atherosclerotic plaques varies widely, and different studies confirm that it is higher in the plaques extracted from patients with unstable angina, myocardial infarction or histologic/angiographic evidence of coronary thrombosis than in those taken from patients with stable angina or uncomplicated coronary lesions. Variations in tissue factor content and activity may be responsible for the different thrombotic responses to human coronary atherosclerotic plaque rupture.
authors.affiliation: Division of Cardiology, I.R.C.C.S. Policlinico San Matteo and University of Pavia, Piazza Golgi 1, 27100, Pavia, Italy. ARDISOO1@planet.it
authors.forename: D
authors.initials: D
authors.lastname: Ardissino
authors.forename: P A
authors.initials: PA
authors.lastname: Merlini
authors.forename: R
authors.initials: R
authors.lastname: Arlens
authors.forename: R
authors.initials: R
authors.lastname: Coppola
authors.forename: E
authors.initials: E
authors.lastname: Bramucci
authors.forename: S
authors.initials: S
authors.lastname: Lucreziotti
authors.forename: A
authors.initials: A
authors.lastname: Repetto
authors.forename: R
authors.initials: R
authors.lastname: Fetiveau
authors.forename: P M
authors.initials: PM
authors.lastname: Mannucci
mesh_terms: D003324:Coronary Artery Disease / Q000378:metabolism*; D006801:Humans; D013925:Thromboplastin / Q000378:metabolism*
chemical_list: D013925:Thromboplastin