Fluconazole inhibits pseudohyphal growth in Saccharomyces cerevisiae.
The ergosterol-depleting antifungal fluconazole, when given at concentrations not affecting growth, inhibited pseudohyphal growth in Saccharomyces cerevisiae, a genetically tractable fungus closely related to the human pathogen Candida albicans. These results suggest that S. cerevisiae could serve as a useful genetic system to study the morphogenetic effects induced by azoles in pathogenic yeast.
Kontoyiannis
D P
DP
Section of Infectious Diseases, Department of Internal Medicine Specialties, The University of Texas M.D. Anderson Cancer Center, Houston, Tex., USA. dkontoyi@notes.mdacc.tmc.edu
D002176:Candida albicans / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism
D015725:Fluconazole