title: Corticobasal ganglionic degeneration and/or frontotemporal dementia? A report of two overlap cases and review of literature.
abstract: OBJECTIVE
  According to the existing viewpoint, Corticobasal degeneration (CBD) is thought of as a predominantly extrapyramidal motor disorder that is distinct and unrelated to frontotemporal dementia (FTD), the most common form of non-Alzheimer dementias. A lack of understanding of the aetiopathogenesis, and poor correlation between the pathology and the clinical syndromes, has resulted in a disparity in the classification of cases of non-Alzheimer dementias. This report intends to highlight the overlap between FTD and CBD in the light of the evolution of these terms, and to discuss the implications of these findings on the nosology of CBD and the classification of non-Alzheimer dementias.
  
  
  RESULTS
  Two cases who presented with cognitive dysfunction, which, on comprehensive neuropsychological testing warranted an antemortem diagnosis of FTD are reported. A detailed necropsy study of their brains, however, favoured a pathological diagnosis of CBD. The literature on the overlap between CBD and FTD is also reviewed.
  
  
  CONCLUSIONS
  Firstly, evidence is emerging to suggest that the clear distinction drawn between FTD and CBD by the existing viewpoint, needs revision. Secondly, until such time that a comprehensive classification of non-Alzheimer dementias is evolved, it may be better to distinguish between the clinical and pathological levels of description and to classify cases, in vivo, on the basis of the clinical phenotype.
authors.affiliation: University of Cambridge Neurology Unit, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Mathuranath
authors.forename: J H
authors.initials: JH
authors.lastname: Xuereb
authors.forename: T
authors.initials: T
authors.lastname: Bak
authors.forename: J R
authors.initials: JR
authors.lastname: Hodges
mesh_terms: D000368:Aged; D001480:Basal Ganglia Diseases / Q000473:pathology* / Q000523:psychology; D002540:Cerebral Cortex / Q000473:pathology*; D003704:Dementia / Q000473:pathology* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D013702:Temporal Lobe / Q000473:pathology*