Excessive apoptosis of bone marrow erythroblasts in a patient with autoimmune haemolytic anaemia with reticulocytopenia.
We report a patient with autoimmune haemolytic anaemia (AIHA) with reticulocytopenia, who showed excessive apoptosis of erythroblasts. Ultrastructural analysis of bone marrow cells showed that 50% of erythroblasts had characteristic features of apoptosis, which was confirmed by staining with Annexin-V. In addition, in contrast to normal erythroblasts, Ig staining of the entire erythroblast population could be shown. These data show that apoptosis may contribute to the mechanism of reticulocytopenia in AIHA.
Van De Loosdrecht
A A
AA
Department of Hematology, Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. a.van.de.loosdrecht@int.azg.nl
Hendriks
D W
DW
Blom
N R
NR
Smit
J W
JW
De Wolf
J T
JT
Vellenga
E
E
D000744:Anemia, Hemolytic, Autoimmune / Q000473:pathology*; D017209:Apoptosis; D004900:Erythroblasts / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D012156:Reticulocytes; D013921:Thrombocytopenia / Q000473:pathology*