title: Contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats.
abstract: The aim of the present study was to establish whether contralateral treatment with local anaesthetics reduces nociceptive behaviour in mononeuropathic rats. Contralateral treatment with xylocaine on day 6 and 11 following sciatic nerve ligation increased withdrawal latencies to thermal but not to mechanical stimulation for 3-4 days. Rats who received contralateral treatment with xylocaine on day 6 and 11 showed a reduced autotomy score during the following 6 weeks. To compare ipsilateral and contralateral effects another set of experiments was performed. Rats treated contralaterally on day 11 had a significantly lower autotomy score at week 4 and 6. Our results demonstrate that contralateral treatment with xylocaine reduces nociceptive behaviour in mononeuropathic rats for days or weeks.
authors.affiliation: Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: I
authors.initials: I
authors.lastname: Bileviciute-Ljungar
authors.forename: T
authors.initials: T
authors.lastname: Lundeberg
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D007839:Functional Laterality; D006614:Hindlimb; D006358:Hot Temperature; D007267:Injections; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D010147:Pain Measurement / Q000187:drug effects*; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D020426:Sciatic Neuropathy / Q000188:drug therapy* / Q000503:physiopathology; D016728:Self-Injurious Behavior / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine