[Determination of language dominance using EEG spectral analysis versus the Wada test in temporal epilepsy (right-handed subjects)].
Spectral analysis of the EEG alpha rhythm was studied in nine temporal epileptic right-handed patients in order to predict localization of the speech area. We studied the variation of the spectral power of the alpha rhythm during an activation paradigm previously validated in normal right-handed subjects. Significant alpha power decreases in the left hemisphere during writing with the right hand (as compared to resting) and/or significant alpha power decreases in the right hemisphere during left-hand recognition and classification of cardboard objects (as compared to resting) were considered as consistent with left-hemisphere dominance for language. The results of EEG spectral analysis were compared with those of the Wada test. The left hemisphere was dominant for language according to the Wada test in eight subjects and the right hemisphere in one subject. Six patients had a significant alpha power reduction in the hemisphere concerned during lateralized cognitive tasks, consistent with language localization in the left hemisphere according to the Wada test. The three remaining patients had no significant EEG spectral power variations. A significant decrease of alpha power in the active hemisphere during cerebral activation seems statistically related to left-hemispheric dominance for language in right-handed subjects (hemispheric specialization). However, the localization of the speech area using this electrophysiological method does not appear clinically relevant for a case-by-case decision in individual patients.
Corcia
P
P
Clinique neurologique, CHU Bretonneau, Tours, France.
De Toffol
B
B
Hommet
C
C
Autret
A
A
D000293:Adolescent; D000328:Adult; D000513:Alpha Rhythm; D000654:Amobarbital / Q000494:pharmacology; D002540:Cerebral Cortex / Q000502:physiology; D003071:Cognition; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects; D006236:Handwriting; D006801:Humans; D007802:Language; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D013060:Speech / Q000187:drug effects
D000654:Amobarbital