Gastrinaemia and G-cell density in the antral gastrocystoplasty: an experimental study in rats.
OBJECTIVE
To evaluate gastrinaemia and G-cell density in the antrum incorporated into the bladder of rats after antrocystoplasty. Materials and methods Thirty-two adult, female Wistar EPM-1 rats (body weight 200-220 g) were divided into four equal groups that underwent; group 1, no treatment (controls); group 2, a sham operation; group 3, antrectomy; and group 4, antrocystoplasty. The rats were assessed 2 months after treatment, and gastrinaemia and the G-cell density determined in the antrum mucosa incorporated into the bladder.


RESULTS
Compared with group 1, serum gastrin was significantly lower in group 3 (P<0.05) and the G-cell density lower in group 4 (P<0.05), although there was no decrease in gastrinaemia in group 4.


CONCLUSIONS
Antrocystoplasty in rats did not affect gastrinaemia but reduced the number of G cells in the antrum incorporated into the bladder.
Ortiz
V
V
Department of Surgery, Divisions of Surgical Research and Urology, Escola Paulista de Medicina - UNIFESP, São Paulo, Brazil.
Goldenberg
S
S
D000714:Anastomosis, Surgical; D000818:Animals; D005260:Female; D019863:Gastrin-Secreting Cells / Q000166:cytology*; D005755:Gastrins / Q000097:blood*; D011706:Pyloric Antrum / Q000378:metabolism / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D019651:Plastic Surgery Procedures / Q000379:methods; D001743:Urinary Bladder / Q000601:surgery*
D005755:Gastrins