title: Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.
abstract: Mycobacterium tuberculosis thymidylate kinase complexed with the substrate deoxythymidine monophosphate was crystallized in the hexagonal space group P6(5)22 or P6(1)22, with unit-cell parameters a = b = 76.62, c = 134.38 A and one single monomer of 23 kDa in the asymmetric unit. Cryo-cooled crystals diffract at 1.94 A resolution using synchrotron radiation.
authors.affiliation: Unité de Biochimie Structurale, Institut Pasteur, 28 Rue du Dr Roux, 75724, Paris CEDEX 15, France.
authors.forename: I
authors.initials: I
authors.lastname: Li de la Sierra
authors.forename: H
authors.initials: H
authors.lastname: Munier-Lehmann
authors.forename: A M
authors.initials: AM
authors.lastname: Gilles
authors.forename: O
authors.initials: O
authors.lastname: Bârzu
authors.forename: M
authors.initials: M
authors.lastname: Delarue
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D003460:Crystallization; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D009703:Nucleoside-Phosphate Kinase / Q000737:chemistry* / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000737:chemistry / Q000378:metabolism; D014961:X-Ray Diffraction
chemical_list: D001426:Bacterial Proteins; D013938:Thymidine Monophosphate; D009703:Nucleoside-Phosphate Kinase; C020093:dTMP kinase