title: Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.
abstract: Chronic Fatigue and/or Fibromyalgia have long been diseases without definition. An explanatory model of coagulation activation has been demonstrated through use of the ISAC panel of five tests, including, Fibrinogen, Prothrombin Fragment 1+2, Thrombin/ AntiThrombin Complexes, Soluble Fibrin Monomer, and Platelet Activation by flow cytometry. These tests show low level coagulation activation from immunoglobulins (Igs) as demonstrated by Anti-B2GPI antibodies, which allows classification of these diseases as a type of antiphospholipid antibody syndrome. The ISAC panel allows testing for diagnosis as well as monitoring for anticoagulation protocols in these patients.
authors.affiliation: HEMEX Laboratories, Inc., Phoenix, Arizona 85021, USA.
authors.forename: D
authors.initials: D
authors.lastname: Berg
authors.forename: L H
authors.initials: LH
authors.lastname: Berg
authors.forename: J
authors.initials: J
authors.lastname: Couvaras
authors.forename: H
authors.initials: H
authors.lastname: Harrison
mesh_terms: D016736:Antiphospholipid Syndrome / Q000145:classification / Q000175:diagnosis*; D019411:Clinical Laboratory Techniques; D003937:Diagnosis, Differential; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis*; D005356:Fibromyalgia / Q000175:diagnosis*; D006801:Humans