Influence of melatonin on immunotoxicity of cadmium.
The results suggested that immunotoxicity induced by Cd was significantly restored or prevented by MLT. MLT (10 or 50 mg/kg) was orally administered to ICR mice daily for 28 consecutive days, and cadmium (Cd, as [Cd(AC)(2)]) was also administered at 25 mg/kg by the same route 2 h after the administration of MLT, and the normal mice were given vehicle. Within the Cd plus MLT-treated group, the body weight gains and relative thymus weights were significantly increased when compared with the treatment of Cd alone. The relative spleen and liver weights were increased by treatment of Cd alone, then restored to normal value by MLT treatment. Hemagglutination (HA) titer, primary IgM antibody response to SRBC, and secondary IgG antibody response to BSA was significantly increased with the Cd plus MLT-treated mice, as opposed to when compared with treatment of Cd alone. The NK cell and phagocytic activity used for evaluation of non-specific immunocompetence was significantly increased in Cd plus MLT-treated mice when compared with the treatment of Cd alone. The number of peripheral leukocytes was significantly increased in Cd plus MLT-treated mice when compared with treatment of Cd alone.
Kim
Y O
YO
Immunotoxicology Division, Toxicology Department, National Institute Toxicological Research, Korea FDA, Eunpyung-Ku, Seoul, South Korea. okjutwo@yahoo.com
Ahn
Y K
YK
Kim
J H
JH
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D006384:Hemagglutination / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D051379:Mice; D008813:Mice, Inbred ICR; D010587:Phagocytosis / Q000187:drug effects
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002104:Cadmium; D008550:Melatonin