[Current concepts of involvement of glutamate in ischemic damage of the brain tissue].
Glutamate neurotoxicity cannot be considered the only reason for neuronal damage. Other neurotransmitters and molecular messengers like nitric oxide, may be involved in the toxic effect of glutamate. Different conditions in focal and global ischemia, stage of the ischemic damage evolution, the degree of ischemia, and activation of glutamate receptors, should also be taken into consideration when assessing a neurological outcome.
Kvrivishvili
G I
GI
Beritashvili Institute of Physiology of the Georgian Acad. Sci., Tbilisi, Georgia.
Mitagvariia
N P
NP
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000378:metabolism*; D006801:Humans; D007511:Ischemia / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid