title: Diagnosis and management of hypertensive emergencies.
abstract: It has been estimated that approximately 600,000 to 800,000 Americans will develop a hypertensive crisis (Calhoun and Oparil, 1990). Although such numbers represent only about 1% of the estimated 60 million Americans with hypertension, hypertensive crisis often constitutes a major medical emergency, necessitating a focused, assertive, and reasoned therapeutic intervention. When such patients are seen in the emergency department or in a physician's office with a critical elevation in blood pressure (BP), appropriate and efficacious management is essential to avoid catastrophic injury to vital target organs, including the central nervous system, the heart, and the kidneys. Delays in initiating effective therapy or, equally important, overzealous therapy leading to a too-rapid reduction in BP can produce severe complications involving these target organs. This article reviews the spectrum of clinical syndromes that comprise hypertensive emergencies, highlighting 2 to illustrate the complexities of clinical presentation and management. The newly advocated treatment guidelines based on the category of acute severe hypertension (including asymptomatic hypertensive urgencies) are also considered, as are therapeutic strategies utilizing currently available antihypertensive agents.
authors.affiliation: Department of Medicine, University of Miami School of Medicine, Florida, USA.
authors.forename: M
authors.initials: M
authors.lastname: Epstein
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000784:Aortic Dissection / Q000150:complications / Q000175:diagnosis; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use; D004630:Emergencies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D009543:Nifedipine / Q000627:therapeutic use; D009599:Nitroprusside / Q000627:therapeutic use; D011654:Pulmonary Edema / Q000150:complications / Q000175:diagnosis / Q000628:therapy*
chemical_list: D000316:Adrenergic alpha-Agonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D009599:Nitroprusside; D009543:Nifedipine; D003000:Clonidine