Role of linkers in communication between protein modules.
Multidomain proteins are common in a variety of cellular processes. Their domains are interconnected through short stretches of amino acid residues referred to as linkers. Recent studies on many systems have provided compelling evidence that linkers are more than simple covalent connectors. They also perform the important task of establishing communication between the different functional modules that exist within such proteins.
Gokhale
R S
RS
Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5025, USA. rsgok@leland.stanford.edu.
Khosla
C
C
D019143:Evolution, Molecular; D007700:Kinetics; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D019061:src-Family Kinases / Q000737:chemistry* / Q000378:metabolism
D009097:Multienzyme Complexes; D019061:src-Family Kinases