title: A novel mechanism of resistance to mouse mammary tumor virus infection.
abstract: Exogenous mouse mammary tumor virus (MMTV) is carried from the gut of suckling pups to the mammary glands by lymphocytes and induces mammary gland tumors. MMTV-induced tumor incidence in inbred mice of different strains ranges from 0 to as high as 100%. For example, mice of the C3H/HeN strain are highly susceptible, whereas mice of the I/LnJ strain are highly resistant. Of the different factors that together determine the susceptibility of mice to development of MMTV-induced mammary tumors, genetic elements play a major role, although very few genes that determine a susceptibility-resistance phenotype have been identified so far. Our data indicate that MMTV fails to infect mammary glands in I/LnJ mice foster nursed on viremic C3H/HeN females, even though the I/LnJ mammary tissue is not refractory to MMTV infection. Lymphocytes from fostered I/LnJ mice contained integrated MMTV proviruses and shed virus but failed to establish infection in the mammary glands of susceptible syngeneic (I x C3H.JK)F(1) females. Based on the susceptible-resistant phenotype distribution in N(2) females, both MMTV mammary gland infection and mammary gland tumor development in I/LnJ mice are controlled by a single locus.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine 04609, USA. tvg@aretha.jax.org
authors.forename: T V
authors.initials: TV
authors.lastname: Golovkina
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000821:virology; D002478:Cells, Cultured; D002874:Chromosome Mapping; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005808:Genes, Recessive; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology; D008297:Male; D008321:Mammary Glands, Animal / Q000276:immunology / Q000821:virology; D008325:Mammary Neoplasms, Experimental / Q000235:genetics / Q000276:immunology* / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants / Q000235:genetics / Q000276:immunology; D012192:Retroviridae Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D014412:Tumor Virus Infections / Q000235:genetics / Q000276:immunology* / Q000821:virology; D017201:Virus Shedding
chemical_list: D004279:DNA, Viral