title: Inter-ocular characteristics of the pre-contact lens tear film.
abstract: OBJECTIVE
  To establish whether the status of the pre-contact lens tear film as indicated by standard, clinical observational techniques is affected by moderate stimulation of the contralateral eye.
  
  
  METHODS
  Four indicators of tear film behavior, lipid layer appearance, amount of debris, inferior meniscus height and non-invasive tear break up time (NIBUT) were monitored in ten subjects before and during 30 minutes of monocular pHEMA contact lens wear. Concurrently, the contralateral eye was either subjected to moderate irritation by means of a silicone elastomer contact lens, or remained unstimulated. Data were compared, between the stimulated and unstimulated states to identify evidence of contralateral treatment effects.
  
  
  RESULTS
  After 30 minutes, maximum contralateral differences between the unstimulated and stimulated conditions were 1 grade for both lipid layer appearance and debris, 0.1 mm for meniscus height and 4 secs for NIBUT.
  
  
  CONCLUSIONS
  The magnitudes of contralateral effects induced by moderate, monocular irritation were comparable with the within-subject variabilities associated with these indicators of tear film behavior.
authors.affiliation: Co-operative Research Centre for Eye Research and Technology, University of New South Wales, Sydney, Australia. e.papas@cclru.unsw.edu.au
authors.forename: E B
authors.initials: EB
authors.lastname: Papas
authors.forename: C M
authors.initials: CM
authors.lastname: Vajdic
mesh_terms: D003261:Contact Lenses; D007839:Functional Laterality; D006801:Humans; D008055:Lipids / Q000032:analysis; D009799:Ocular Physiological Phenomena; D015203:Reproducibility of Results; D012826:Silicone Elastomers; D013666:Tears / Q000737:chemistry / Q000502:physiology*
chemical_list: D008055:Lipids; D012826:Silicone Elastomers