title: Phenotypic characterisation of Candida albicans isolated from chronic hyperplastic candidosis.
abstract: The phenotypes of 35 Candida albicans isolates from 19 patients with chronic hyperplastic candidosis (CHC) and 35 isolates from 30 patients with non-CHC infections were compared. Typing was based on carbohydrate assimilation, chemical sensitivity and serology. Eight carbohydrate assimilation profiles were evident with the API-20C system and a single profile predominated for isolates from CHC (17 of 19 patients; 89%) and non-CHC (18 of 30 patients; 63%). Chemical sensitivity tests revealed four profiles with no significant difference between CHC and non-CHC isolates. Serotype A predominated for isolates from both CHC (15 of 19 patients; 79%) and non-CHC (25 of 30 patients; 83%) infections. Boric acid resistance was more prevalent in CHC isolates, although a significant difference was not apparent. In summary, there was no overall difference in the phenotypes of isolates from CHC and non-CHC patients, and clonal restriction of CHC isolates was not demonstrated.
authors.affiliation: Department of Oral Surgery, Medicine and Pathology, Dental School, Heath Park, Cardiff, CF4 4XY, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Williams
authors.affiliation: Department of Oral Surgery, Medicine and Pathology, Dental School, Heath Park, Cardiff, CF4 4XY, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Wilson
authors.affiliation: Department of Oral Surgery, Medicine and Pathology, Dental School, Heath Park, Cardiff, CF4 4XY, UK.
authors.forename: A J C
authors.initials: AJC
authors.lastname: Potts
authors.affiliation: Department of Oral Surgery, Medicine and Pathology, Dental School, Heath Park, Cardiff, CF4 4XY, UK.
authors.forename: M A O
authors.initials: MAO
authors.lastname: Lewis
mesh_terms: D002176:Candida albicans / Q000145:classification* / Q000302:isolation & purification* / Q000378:metabolism; D002180:Candidiasis, Oral / Q000382:microbiology*; D002908:Chronic Disease; D006801:Humans; D006965:Hyperplasia; D009055:Mouth / Q000382:microbiology; D016533:Mycological Typing Techniques; D010641:Phenotype; D012703:Serotyping