[The relation of the changes of SOD and PGE2 in aqueous humor with the transient rise of intraocular pressure after argon laser iridectomy].
OBJECTIVE
To study the mechanism of transient rise of the intraocular pressure (IOP) after argon laser iridectomy (ALI).


METHODS
The rabbit changes of IOP, the activity of superoxide dismutase (SOD) and the concentration of prostaglandin E2 (PGE2) in aqueous 15 min, 60 min, 6 hr, 24 hr, 48 hr after ALI, the relationships of these changes with the transient rise of IOP, and the effects of using indomethacin, cortisone, vitamin E and C before ALI on the transient rise of IOP were observed.


RESULTS
After ALI, the transient rise of IOP took place within postoperative 6 hr. Following the postoperative transient rise of IOP, the concentration of PGE2 in the aqueous was markedly increased, but the activity of SOD in the aqueous markedly decreased. When indomethacin, cortisone, vitamin E and C were used before ALI, the concentration of PGE2 was not markedly increased, the activity of SOD was not markedly decreased and the postoperative transient rise of IOP did not take place.


CONCLUSIONS
The transient rise of IOP after ALI is related to the increase of concentration of PGE2 and the decrease of activity of SOD in the aqueous. Using indomethacin, cortisone, vitamin E and C before ALI can effectively prevent the postoperative transient rise of IOP.
He
J
J
Department of Ophthalmology, Affiliated Hospital of Qingdao Medical College, Qingdao.
Qiu
Y
Y
Sun
W
W
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D007429:Intraocular Pressure; D007498:Iris / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D011184:Postoperative Period; D011817:Rabbits; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase; D015232:Dinoprostone