title: Silicone oil vs. gas for the treatment of full-thickness macular hole.
abstract: The purpose of this study is to evaluate the anatomic and visual outcomes, as well as the complications, of macular hole surgery with SF6-gas tamponade versus silicone-oil tamponade. Fifty-four (54) eyes with idiopathic macular hole underwent vitrectomy and peeling of the internal limiting membrane (ILM) around the hole. Nineteen (19) eyes were treated with SF6-gas tamponade (group 1) and the other thirty-five (35) eyes with silicone-oil tamponade (group 2). An excellent anatomic success rate was obtained in both groups (94.7% in group 1 and 97.1% in group 2). Nevertheless, the postoperative visual acuity (VA) in the group treated with silicone-oil tamponade was significantly better than in the group treated with gas tamponade (P = 0.0217). Forty-seven (47) of the eyes in group 1 and 74% in group 2 achieved a VA = 0.4 or better. The most frequent potentially vision threatening complication we observed was RPE alterations in 35% of the eyes in group 1 and in only one eye in group 2. None of the eyes developed a retinal detachment during the follow-up period. In conclusion, the treatment of idiopathic macular holes by vitrectomy and ILM peeling provides a very good anatomic success rate. An excellent recovery of visual acuity, up to 1.0, was more frequently observed in the group treated with silicone oil tamponade.
authors.affiliation: Middelheim Hospital, Antwerpen.
authors.forename: G
authors.initials: G
authors.lastname: Pertile
authors.forename: C
authors.initials: C
authors.lastname: Claes
mesh_terms: D000368:Aged; D003517:Cyclopentanes / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005466:Fluorocarbons / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005740:Gases / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000209:etiology; D012167:Retinal Perforations / Q000628:therapy*; D012827:Silicone Oils / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D003517:Cyclopentanes; D005466:Fluorocarbons; D005740:Gases; D012827:Silicone Oils; C115615:perfluoromethylcyclopentane