Effects of propofol anesthesia on cognitive recovery of patients undergoing electroconvulsive therapy.
The effects of different doses of propofol on post-electroconvulsive therapy (ECT) cognitive recovery were evaluated together with the effects on seizure duration and hemodynamic changes during ECT in 15 depressive patients. Propofol attenuated the increase in arterial blood pressure and heart rate in a dose-dependent manner compared with thiamylal. Propofol showed a clinically significant anticonvulsant effect during ECT in a dose-dependent manner. There were no significant differences among the four different induction groups in the mean recovery time from anesthesia, however, a low dose of propofol suppressed the early recovery of cognitive function. For early cognitive recovery after ECT, a deep anesthetic level is necessary when the traditional ECT apparatus is used which produces sine curve wave stimuli.
Sakamoto
A
A
Department of Anesthesiology, Nippon Medical School, Tokyo, Japan.
Hoshino
T
T
Suzuki
N
N
Suzuki
H
H
Kimura
M
M
Ogawa
R
R
D000328:Adult; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects; D003071:Cognition / Q000187:drug effects*; D018592:Cross-Over Studies; D004565:Electroconvulsive Therapy; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects; D011569:Psychiatric Status Rating Scales; D013840:Thiamylal / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors
D018686:Anesthetics, Intravenous; D013840:Thiamylal; D015742:Propofol