Age-specific effects of noradrenergic alpha-2 agonist clonidine on the development of amygdaloid kindling in developing rats.
The effects of clonidine on the development of amygdaloid kindling were studied in rats of various ages (14, 21, 28 and 70 postnatal days). Administration of clonidine (0.2, 0.5 mg/kg i.p.) caused a significant retardation of kindling development in the 28-day-old rats as well as in the adult rats, whereas, in the 14-day-old rats, the development of kindling was significantly facilitated by clonidine. No significant effect of clonidine was observed in the 21-day-old rats. These results indicate that in rats the effects of clonidine on the development of amygdaloid kindling vary during development.
Yoshioka
S
S
Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 86, Nishi-machi, Yonago, Japan. shiyoshi@grape.med.tottori-u.ac.jp
Mitani
H
H
Maeda
K
K
Takeo
S
S
Matsuda
K
K
Katayama
S
S
Mizukawa
R
R
Kawahara
R
R
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects*; D000679:Amygdala / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000316:Adrenergic alpha-Agonists; D000927:Anticonvulsants; D003292:Convulsants; D003000:Clonidine