title: Survey of the proton affinities of adenine, cytosine, thymine and uracil dideoxyribonucleosides, deoxyribonucleosides and ribonucleosides.
abstract: The kinetic method was applied to the determination of the proton affinities (PAs) of modified deoxy- and dideoxyribonucleosides. A correlation between the measured PAs and the replacement of one of the three hydroxyl groups of the ribose unit is presented. A PA scale was obtained which shows that the replacement of the primary or of one or both secondary hydroxyl groups of a ribonucleoside with a hydrogen atom induces the lowering or the enhancement of the nucleoside PA, respectively. The scale extends over a very narrow range of approximately 2 kcal mol(-1), thus demonstrating the sensitivity of the kinetic method in the evaluation of small differences in thermodynamic parameters.
authors.affiliation: Dipartimento di Chimica, Università della Calabria, Via P. Bucci, cubo 15/c, I-87030 Arcavacata di Rende (CS), Italy.
authors.forename: A
authors.initials: A
authors.lastname: Liguori
authors.forename: A
authors.initials: A
authors.lastname: Napoli
authors.forename: G
authors.initials: G
authors.lastname: Sindona
mesh_terms: D000227:Adenine Nucleotides / Q000737:chemistry; D000465:Algorithms; D003597:Cytosine Nucleotides / Q000737:chemistry; D003853:Deoxyribonucleosides / Q000737:chemistry; D015224:Dideoxynucleosides / Q000737:chemistry; D007700:Kinetics; D009705:Nucleosides / Q000737:chemistry*; D011522:Protons; D012263:Ribonucleosides / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013816:Thermodynamics; D013942:Thymine Nucleotides / Q000737:chemistry; D014500:Uracil Nucleotides / Q000737:chemistry
chemical_list: D000227:Adenine Nucleotides; D003597:Cytosine Nucleotides; D003853:Deoxyribonucleosides; D015224:Dideoxynucleosides; D009705:Nucleosides; D011522:Protons; D012263:Ribonucleosides; D013942:Thymine Nucleotides; D014500:Uracil Nucleotides