title: Midline developmental anomalies with lipomas in the corpus callosum region.
abstract: Three children with complete or partial callosal aplasia and intracranial lipoma in the corpus callosum region were investigated. Two lipomas were tubulonodular; one replaced the entire corpus callosum structure. Accompanying anomalies affected the cingulate gyrus, septum pellucidum, and choroid plexus. In one case, diagnosis was made in utero in the 25th gestational week by ultrasonography; in the second case it was made on the first day of life, also by screening ultrasonography. Two children had mild spastic distal diparesis; one complained of chronic headache. Electroencephalography showed no abnormalities; epilepsy anamnesis was negative. Somatosensory and visual evoked potentials showed prolonged conduction in two cases. Surgery was not indicated. Because of the risk of developing epileptic seizures, regular electroencephalographic follow-up investigations are essential.
authors.affiliation: Department of Pediatric Neurology, Johann Wolfgang Goethe-University, Frankfurt/Main, Germany. mkieslich@zki.uni-frankfurt.de
authors.forename: M
authors.initials: M
authors.lastname: Kieslich
authors.forename: S
authors.initials: S
authors.lastname: Ehlers
authors.forename: M
authors.initials: M
authors.lastname: Bollinger
authors.forename: G
authors.initials: G
authors.lastname: Jacobi
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002675:Child, Preschool; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology*; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008067:Lipoma / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009431:Neural Conduction / Q000502:physiology; D014057:Tomography, X-Ray Computed