title: Noradrenaline does not change the mode of discharge of auditory cortex neurons.
abstract: The mode of discharge of auditory cortex cells was studied during iontophoretic application of noradrenaline (NA). Only seven of 190 cells showed changes in interspike interval distribution during NA application. A similar conclusion was drawn when the analysis focused on 68 cells classified as bursting (n = 15), regular spiking (n = 49) or thin spike (n = 4) cells. Only two bursting cells showed changes in their ISI distribution. The effects on the mode of discharge were independent of the effect on the spike rate and were not a function of cortical depth. These results suggest that the changes in firing mode previously described in vitro occur for a limited percentage of cells and/or for cell types not very often recorded in vivo.
authors.affiliation: Laboratoire de Neurobiologie de l'Apprentissage, de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris-Sud, Orsay, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Manunta
authors.forename: J M
authors.initials: JM
authors.lastname: Edeline
mesh_terms: D000758:Anesthesia; D000818:Animals; D001303:Auditory Cortex / Q000166:cytology / Q000187:drug effects*; D004594:Electrophysiology; D007478:Iontophoresis; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D009638:Norepinephrine