A kindred with Parkinson's disease not showing genetic linkage to established loci.
We describe a kindred with PD with an onset age from the fifth to the eighth decade. Genetic analysis indicated that the genetic defect in this family was unlikely to be in the alpha-synuclein, parkin, or tau genes, or to reside on chromosomes 2p or 4p.
Gwinn-Hardy
K A
KA
Mayo Clinic Jacksonville, FL 32224, USA.
Crook
R
R
Lincoln
S
S
Adler
C H
CH
Caviness
J N
JN
Hardy
J
J
Farrer
M
M
D000368:Aged; D005192:Family Health; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008824:Michigan; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D014202:Tremor / Q000235:genetics