[Peculiarities of cell reception in bronchial asthma patients with bronchial hyperreactivity to hyperosmolar provocation].
OBJECTIVE
To investigate characteristics of the cell receptor systems in bronchial asthma (BA) patients with bronchial hyperreactivity (BHR) induced by hyperosmolar provocation.


METHODS
15 patients with BA, in most cases atopic, in remission were studied. The bronchoprovocative test (BPT) with ultrasonically nebulized 3.6% hypertonic NaCl solution (UNHS) FEV1-control was performed. Cell receptors reactivity was analysed on the model of erythrocyte resistance (ER) to hyperosmolar provocation (HP) under the modulation by adrenergic and histaminergic agents.


RESULTS
It was revealed that ER was significantly higher (p < 0.05) in BA patients with BHR to UNHS under histaminergic modulation, but ER did not differ in BA patients with or without BHR to UNHS under the adrenergic modulation. The correlation was found between DFEV1 on BPT and magnitude of ER to HP under the blockade of H1-histaminergic receptors (r = 0.72; p < 0.02).


CONCLUSIONS
The development of BHR to hyperosmolar stimulus may be due primarily to disturbance of histaminergic receptor system.
Minaev
V N
VN
Sinitsina
T M
TM
Adamova
I V
IV
Nesterovich
I I
II
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D001985:Bronchial Provocation Tests / Q000379:methods*; D016084:Bronchoconstriction / Q000187:drug effects / Q000502:physiology; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D009994:Osmolar Concentration; D011379:Prognosis; D011941:Receptors, Adrenergic / Q000502:physiology*; D011968:Receptors, Histamine / Q000502:physiology*; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage
D011941:Receptors, Adrenergic; D011968:Receptors, Histamine; D012462:Saline Solution, Hypertonic