title: A search for natural bioactive compounds in Bolivia through a multidisciplinary approach. Part I. Evaluation of the antimalarial activity of plants used by the Chacobo Indians.
abstract: Thirty extracts of plants traditionally used by the Chacobos, a native community living in the Amazonian part of Bolivia, were screened in vitro and/or in vivo for antimalarial activity. Two of the four species designated as antimalarial, Geissospermum laeve and Maquira coriacea, displayed rather good activity, corroborating their traditional uses. However, they did show a rather high toxicity in vivo. Among twelve species used to cure symptoms relevant to malaria, five showed good activity: Apuleia leiocarpa, Bauhinia guianensis, Nectandra cuspidata, Sparattanthelium amazonum, Tanaecium jaroba. Two species, Qualea paraensis and Sclerolobium aff. guianense, used to treat scabies, showed interesting antimalarial activity in vivo; three other species (Iryanthera laevis, Prunus amplifolia, Pterocarpus aff. amazonum) used for various medicinal purposes, apparently not related with a Plasmodium infection, also showed antimalarial activity. Finally, one species (Derris amazonica) used as a piscicide displayed good in vitro activity, in the same way as one Annonaceae, Guatteria aff. schomburgkiana, used for construction purposes.
authors.affiliation: Instituto Boliviano de Biologia de Altura, La Paz, Bolivia.
authors.forename: V
authors.initials: V
authors.lastname: Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Sauvain
authors.forename: G
authors.initials: G
authors.lastname: Bourdy
authors.forename: J
authors.initials: J
authors.lastname: Callapa
authors.forename: S
authors.initials: S
authors.lastname: Bergeron
authors.forename: I
authors.initials: I
authors.lastname: Rojas
authors.forename: J A
authors.initials: JA
authors.lastname: Bravo
authors.forename: L
authors.initials: L
authors.lastname: Balderrama
authors.forename: B
authors.initials: B
authors.lastname: Ortiz
authors.forename: A
authors.initials: A
authors.lastname: Gimenez
authors.forename: E
authors.initials: E
authors.lastname: Deharo
mesh_terms: D000818:Animals; D008297:Male; D051379:Mice; D000962:Antimalarials / Q000627:therapeutic use / Q000633:toxicity; D001838:Bolivia; D004353:Drug Evaluation, Preclinical / Q000379:methods; D066298:In Vitro Techniques; D007199:Indians, South American; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000627:therapeutic use / Q000633:toxicity; D010961:Plasmodium / Q000187:drug effects; D010962:Plasmodium berghei / Q000187:drug effects; D006801:Humans
chemical_list: D000962:Antimalarials; D010936:Plant Extracts