title: Angiographical and Doppler flow-derived parameters for assessment of coronary lesion severity and its relation to the result of exercise electrocardiography. DEBATE study group. Doppler Endpoints Balloon Angioplasty Trial Europe.
abstract: OBJECTIVE
  Evaluation of angiographical and intracoronary Doppler-derived parameters of coronary stenosis severity.
  
  
  RESULTS
  A total of 225 patients with one-vessel disease were studied before PTCA and at 6 months follow-up. Exercise electrocardiography was performed to document presence (n = 157) or absence (n = 138) of an ST segment shift (> or =0.1 mV). Intracoronary blood flow velocity analysis was performed to determine the proximal/distal flow velocity ratio, the distal diastolic/systolic flow velocity ratio and coronary flow velocity reserve. Receiver operator characteristic curves were calculated to assess the predictive value of these variables compared with the exercise test. The distal coronary flow velocity reserve demonstrated the best linear correlation for both percentage diameter stenosis and minimum lumen diameter (r = 0.67 and r = 0.66; P<0.01), compared to the diastolic/systolic flow velocity ratio (r = 0.19 and r = 0.14; P<0.01) and the proximal/distal flow velocity ratio (r = 0.03 and r = 0.07; not significant). The areas under the curve were 0. 84+/-0.02; 0.82+/-0.03 and 0.83+/-0.03 for diameter stenosis, minimum lumen diameter and coronary flow velocity reserve, respectively. Logistic regression analysis revealed that the percentage diameter stenosis or minimum lumen diameter and coronary flow velocity reserve were independent predictors for the result of stress testing.
  
  
  CONCLUSIONS
  The distal coronary flow velocity reserve is the best intracoronary Doppler parameter for evaluation of coronary narrowings. Angiographical estimates of coronary lesion severity and distal coronary flow velocity reserve are good and independent predictors for the assessment of functional severity of coronary stenosis, emphasizing the complementary role of these parameters for clinical decision making.
authors.affiliation: Department of Cardiology, Academical Medical Center, Amsterdam, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Piek
authors.forename: E
authors.initials: E
authors.lastname: Boersma
authors.forename: C
authors.initials: C
authors.lastname: di Mario
authors.forename: E
authors.initials: E
authors.lastname: Schroeder
authors.forename: C
authors.initials: C
authors.lastname: Vrints
authors.forename: P
authors.initials: P
authors.lastname: Probst
authors.forename: B
authors.initials: B
authors.lastname: de Bruyne
authors.forename: C
authors.initials: C
authors.lastname: Hanet
authors.forename: E
authors.initials: E
authors.lastname: Fleck
authors.forename: M
authors.initials: M
authors.lastname: Haude
authors.forename: E
authors.initials: E
authors.lastname: Verna
authors.forename: V
authors.initials: V
authors.lastname: Voudris
authors.forename: H
authors.initials: H
authors.lastname: Geschwind
authors.forename: H
authors.initials: H
authors.lastname: Emanuelsson
authors.forename: V
authors.initials: V
authors.lastname: Mühlberger
authors.forename: H O
authors.initials: HO
authors.lastname: Peels
authors.forename: P W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000328:Adult; D015906:Angioplasty, Balloon, Coronary; D001783:Blood Flow Velocity; D017023:Coronary Angiography / Q000592:standards*; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology*; D004562:Electrocardiography; D005060:Europe; D005080:Exercise Test; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry / Q000592:standards*; D016015:Logistic Models; D008297:Male; D011237:Predictive Value of Tests; D012720:Severity of Illness Index