title: Prediction of detached personality in healthy subjects by low dopamine transporter binding.
abstract: OBJECTIVE
  Low striatal dopamine D(2) receptor binding in healthy human subjects has been associated with detached personality in studies using positron emission tomography (PET) and the Karolinska Scales of Personality questionnaire. The authors investigated whether a similar correlation exists between striatal dopamine transporter binding and detached personality.
  
  
  METHODS
  Eighteen healthy volunteers participated in a PET study with the specific dopamine transporter ligand [(18)F]CFT ([(18)F]WIN 35,428) and completed the Karolinska Scales of Personality questionnaire form.
  
  
  RESULTS
  Age-corrected dopamine transporter binding in the putamen, but not in the caudate, correlated negatively with detachment personality scores, especially in the right hemisphere.
  
  
  CONCLUSIONS
  This finding supports the hypothesis that low dopaminergic neurotransmission is associated with detached personality. Furthermore, since [(18)F]CFT binding is thought to reflect the density of dopaminergic nerve terminals in the brain, the authors suggest that the neurodevelopmental formation of the brain dopaminergic system may influence adult personality traits.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, University of Turku, Finland. akilaa@utu.fi
authors.forename: A
authors.initials: A
authors.lastname: Laakso
authors.forename: H
authors.initials: H
authors.lastname: Vilkman
authors.forename: J
authors.initials: J
authors.lastname: Kajander
authors.forename: J
authors.initials: J
authors.lastname: Bergman
authors.forename: M
authors.initials: M
authors.lastname: paranta
authors.forename: O
authors.initials: O
authors.lastname: Solin
authors.forename: J
authors.initials: J
authors.lastname: Hietala
mesh_terms: D000328:Adult; D000367:Age Factors; D002352:Carrier Proteins / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives; D003342:Corpus Striatum / Q000737:chemistry / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D015999:Multivariate Analysis; D009419:Nerve Tissue Proteins; D010551:Personality / Q000145:classification* / Q000502:physiology; D010555:Personality Inventory; D011699:Putamen / Q000737:chemistry / Q000000981:diagnostic imaging / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine; D004298:Dopamine