[Anxiety and behavior in WAG/Rij strain rats with genetically induced absence attacks].
Behavior of nonlinear rats and animals from Wistar and WAG/Rij (with inborn generalized absence epilepsy) strains was examined in the elevated plus-maze and the hole board. WAG/Rij rats demonstrated low exploratory behavior in both tests. In the elevated plus-maze, WAG/Rij rats were more balanced and more anxious than Wistar and nonlinear rats. Administration of ethosuximide completely eliminated spike-wave discharges but did not change behavioral interstrain differences. Since the spike-wave patterns develop in WAG/Rij at the age of 3 months, the behavior of young (2-moth-old) pups from different strains was compared and significant differences were revealed. Correlation between the genetically defined features (spike-wave discharges) and behavioral peculiarities in WAG/Rij rats is supposed.
Kliueva
Iu A
IuA
Lomonosov State University, Moscow.
Chepurnova
N E
NE
Berdiev
R K
RK
Mart'ianov
A A
AA
Mogimi
A
A
Chepurnov
S A
SA
D000375:Aging / Q000235:genetics / Q000502:physiology; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology*; D004644:Emotions / Q000502:physiology; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology*; D005106:Exploratory Behavior / Q000502:physiology; D020022:Genetic Predisposition to Disease; D018782:Maze Learning / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics / Q000502:physiology*; D017208:Rats, Wistar; D018709:Statistics, Nonparametric