title: Seasonal variation in CSF 5-HIAA concentrations in male rhesus macaques.
abstract: Seasonal changes in cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) concentrations were assessed on multiple occasions in 103 free-ranging male rhesus macaques (Macaca mulatta). At the time of sampling subjects ranged between the ages of 2 and 6 years. CSF samples were collected between the hours of 0900 and 1600 throughout the Fall, Winter, and Spring from 1990 through 1994. Data were analyzed in a general linear mixed model with random intercepts. Results indicated that CSF 5-HIAA concentrations decreased with age. CSF 5-HIAA concentrations were significantly increased in the Fall (October and November), which is the height of the breeding season, with no evidence of differences between Winter and Spring. There was also some evidence that the seasonal variation in CSF 5-HIAA concentrations was blunted in younger, more immature subjects.
authors.affiliation: Laboratory of Comparative Ethology, National Institute of Child Health and Human Development, Poolesville, MD, USA.
authors.forename: K B
authors.initials: KB
authors.lastname: Zajicek
authors.forename: C S
authors.initials: CS
authors.lastname: Price
authors.forename: S E
authors.initials: SE
authors.lastname: Shoaf
authors.forename: P T
authors.initials: PT
authors.lastname: Mehlman
authors.forename: S J
authors.initials: SJ
authors.lastname: Suomi
authors.forename: M
authors.initials: M
authors.lastname: Linnoila
authors.forename: J D
authors.initials: JD
authors.lastname: Higley
mesh_terms: D000375:Aging / Q000134:cerebrospinal fluid*; D000704:Analysis of Variance; D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008253:Macaca mulatta / Q000134:cerebrospinal fluid*; D008297:Male; D012621:Seasons
chemical_list: D006897:Hydroxyindoleacetic Acid