[Interest in an glutamate antagonistic compound for the treatment of organophosphate poisoning].
Classical emergency treatment of organophosphate poisoning includes the combined administration of a cholinesterase reactivator (an oxime), a muscarinic cholinergic receptor antagonist (atropine) and a benzodiazepine anticonvulsant (diazepam). In subjects taking pyridostigmine and trained to autoadminister at least one autoinjector at the first signs of poisoning, classical emergency treatment ensures survival but only an antiglutamatergic compound like gacyclidine appears to be able to ensure optimal management of nerve agent poisoning in terms of rapid normalization of EEG activity, clinical recovery and total neuroprotection. All of this reinforces the therapeutical value of gacyclidine, which is in the process of approval for human use in France for treatment of head injury, as a central nervous system protective agent for the treatment of OP poisoning.
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Centre de Recherches du Service de Santé des Armées, Département de Toxicologie, Unité de Neuropharmacologie, 24, avenue des Maquis du Grésivaudan, F 38702 La Tronche Cedex.
D001285:Atropine / Q000008:administration & dosage / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000008:administration & dosage / Q000627:therapeutic use*; D003510:Cyclohexanes / Q000627:therapeutic use*; D053138:Cyclohexenes; D004569:Electroencephalography / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D062025:Organophosphate Poisoning; D010880:Piperidines / Q000627:therapeutic use*; D011041:Poisoning / Q000188:drug therapy*; D011729:Pyridostigmine Bromide / Q000008:administration & dosage / Q000627:therapeutic use; D012646:Self Administration
D002801:Cholinesterase Reactivators; D003510:Cyclohexanes; D053138:Cyclohexenes; D018691:Excitatory Amino Acid Antagonists; D010880:Piperidines; D001285:Atropine; C070707:gacyclidine; D011729:Pyridostigmine Bromide