Epstein-Barr virus-associated high-grade anaplastic plasmacytoma in a renal transplant patient.
Allograft transplant patients have an increased risk of developing polyclonal or monoclonal lymphoproliferative disorders, but high-grade anaplastic plasmacytomas are extremely rare in these patients. We present a renal transplant patient who developed multiple extramedullary high-grade anaplastic plasmacytomas in the oral cavity, the left maxillary antrum, the scalp, the thigh and the upper abdominal wall with no evidence of diffuse bone marrow infiltration. Epstein-Barr virus (EBV) mRNA transcripts were detected within the myeloma cells by in situ hybridization using EBER1-2 probes. Following discontinuation of immunosuppression applied, the patient was treated with a cyclophosphamide-prednisone regimen followed by local irradiation, and a complete remission was achieved within four weeks. We concluded that EBV-associated high-grade anaplastic plasmacytomas constitute one more type of post-transplant lymphoproliferative disorder, and that despite their characterization as highly malignant neoplasms, their clinical behavior is not always aggressive.
Papadaki
H A
HA
Department of Haematology, University of Crete School of Medicine, University Hospital of Heraklion, Greece.
Stefanaki
K
K
Kanavaros
P
P
Katonis
P
P
Papastathi
H
H
Valatas
W
W
Stylianoy
K
K
Eliopoulos
G D
GD
D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000209:etiology / Q000473:pathology / Q000821:virology; D009101:Multiple Myeloma / Q000209:etiology* / Q000473:pathology / Q000821:virology; D012535:Scalp; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology / Q000821:virology