title: Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives.
abstract: Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives.
authors.affiliation: Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Rome, Italy. biava@axrma.uniroma1.it
authors.forename: M
authors.initials: M
authors.lastname: Biava
authors.forename: R
authors.initials: R
authors.lastname: Fioravanti
authors.forename: G C
authors.initials: GC
authors.lastname: Porretta
authors.forename: G
authors.initials: G
authors.lastname: Sleiter
authors.forename: D
authors.initials: D
authors.lastname: Deidda
authors.forename: G
authors.initials: G
authors.lastname: Lampis
authors.forename: R
authors.initials: R
authors.lastname: Pompei
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D013045:Species Specificity; D013055:Spectrophotometry, Infrared; D014052:Toluidines / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D014052:Toluidines