Synthesis of new derivatives of 1,2,3,4,7-pentamethylbicyclo[2.2.1]hept-2-ene-5,6-dicarboximide with an expected anxiolytic activity.
The preparation of a number of derivatives of 1,2,3,4,7-pentamethylbicyclo[2.2.1]hept-2-ene-5,6-dicarboximide with potential anxiolytic activity has been described. The aim of our study was to obtain new analogues of tandospirone, that is derivatives of cyclic imides [1].
Kossakowski
J
J
Department of Medical Chemistry, Medical University of Warsaw, Poland.
Kuśmierczyk
J
J
D000475:Alkenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D018687:Antidepressive Agents, Second-Generation / Q000138:chemical synthesis / Q000494:pharmacology; D014150:Antipsychotic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects; D044263:Receptors, Serotonin, 5-HT1; D013055:Spectrophotometry, Infrared
D000475:Alkenes; D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D014150:Antipsychotic Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1