Tubby-like protein 1 as an autoantigen in cancer-associated retinopathy.
Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome that is characterized by retinal degeneration. Two cDNA clones, recoverin and tubby-like protein 1 (TULP1), were isolated from a human retinal cDNA library by using serum from a CAR patient as the probe. Both recoverin and TULP1 are retina-specific protein, and TULP1 is a member of tubby gene family. A determination of the recognized amino acid sequence of TULP1 by the patient serum and immunohistochemical studies on the distribution of TULP1 in the retina were done in this study.
Kikuchi
T
T
Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
Arai
J
J
Shibuki
H
H
Kawashima
H
H
Yoshimura
N
N
D000595:Amino Acid Sequence; D001324:Autoantigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D018076:DNA, Complementary / Q000302:isolation & purification; D016889:Endometrial Neoplasms / Q000276:immunology*; D000939:Epitopes; D005136:Eye Proteins / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D008875:Middle Aged; D008969:Molecular Sequence Data; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D012162:Retinal Degeneration / Q000276:immunology*
D001324:Autoantigens; D018076:DNA, Complementary; D000939:Epitopes; D005136:Eye Proteins; C105443:TULP1 protein, human