title: Olive oil phenolics are dose-dependently absorbed in humans.
abstract: Olive oil phenolic constituents have been shown, in vitro, to be endowed with potent biological activities including, but not limited to, an antioxidant action. To date, there is no information on the absorption and disposition of such compounds in humans. We report that olive oil phenolics, namely tyrosol and hydroxytyrosol, are dose-dependently absorbed in humans after ingestion and that they are excreted in the urine as glucuronide conjugates. Furthermore, an increase in the dose of phenolics administered increased the proportion of conjugation with glucuronide.
authors.affiliation: Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy. francesco.visioli@unimi.it
authors.forename: F
authors.initials: F
authors.lastname: Visioli
authors.forename: C
authors.initials: C
authors.lastname: Galli
authors.forename: F
authors.initials: F
authors.lastname: Bornet
authors.forename: A
authors.initials: A
authors.lastname: Mattei
authors.forename: R
authors.initials: R
authors.lastname: Patelli
authors.forename: G
authors.initials: G
authors.lastname: Galli
authors.forename: D
authors.initials: D
authors.lastname: Caruso
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000493:pharmacokinetics*; D004042:Dietary Fats, Unsaturated; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D000069463:Olive Oil; D010636:Phenols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D010626:Phenylethyl Alcohol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000652:urine; D010938:Plant Oils / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils; C005975:3,4-dihydroxyphenylethanol; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol