Enhanced susceptibility to subcutaneous abscess formation and persistent infection around catheters is associated with sustained interleukin-1beta levels.
A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was found. Apparently, sustained levels of IL-1beta are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.
Boelens
J J
JJ
Department of Medical Microbiology, Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands. boelensjj@yahoo.com
Zaat
S A
SA
Murk
J L
JL
Weening
J J
JJ
van Der Poll
T
T
Dankert
J
J
D000038:Abscess / Q000209:etiology*; D000818:Animals; D001672:Biocompatible Materials; D002408:Catheters, Indwelling / Q000009:adverse effects*; D004198:Disease Susceptibility; D005260:Female; D007375:Interleukin-1 / Q000032:analysis / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013203:Staphylococcal Infections / Q000209:etiology*; D013212:Staphylococcus epidermidis
D001672:Biocompatible Materials; D007375:Interleukin-1