[The effect of tangential excision on the local IL-8 release and wound inflammatory response in deep-partial thickness burn].
OBJECTIVE
The aim of this study is to investigate the effect of tangential excision on the local IL-8 release and wound inflammatory response.


METHODS
The tissue specimens, which were taken from 7 patients with deep partial thickness burn before and after operation, were both cultured and histopathologically examined. The level of IL-8 in the culture medium was assayed, meanwhile local inflammatory response of tissue samples was evaluated.


RESULTS
The result showed that the level of IL-8 is much lower in the postoperation wounds, while in the non-operation wounds the neutrophil infiltration was marked, with enlargement in necrotic area and disappearance of skin appendages.


CONCLUSIONS
The findings suggested that tangential excision could reduce the local production of IL-8 and decrease local inflammatory response, which is helpful to prevent the progressive necrosis of burn wound.
Lu
S
S
Burn Institute, Ruijin Hospital, Shanghai Second Medical University.
Jin
S
S
Qing
C
C
D000328:Adult; D002056:Burns / Q000378:metabolism* / Q000473:pathology / Q000601:surgery*; D046508:Culture Techniques; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D018375:Neutrophil Activation; D011184:Postoperative Period; D014946:Wound Infection / Q000378:metabolism*
D016209:Interleukin-8