[A comparison study on the sensitivity of lung tumor short-term induction test in three strains of mice].
To compare the sensitivities of lung tumor short-term induction in different strains of mice, the carcinogenicity risk was evaluated with the incidence rate and the average number of tumors. Three different strains of mice (KM, BALB/c and A/J) were injected with a single different dose of urethane i.p. The results demonstrated that the lowest dose for increasing tumor risk was 100 mg/kg in KM, 200 mg/kg in BALB/c, and lower than 25 mg/kg in A/J strain. So, the sensitivity of A/J strain is the highest and that of BALB/c is the lowest.
Dong
Q
Q
Department of Toxicology, School of Public Health, Chengdu.
Li
S
S
Xiao
B
B
Zhang
X
X
Liu
X
X
D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D013045:Species Specificity; D014520:Urethane
D002273:Carcinogens; D014520:Urethane