High-resolution DNA flow cytometry in oral verrucous carcinoma.
The classification of verrucous carcinoma as an entity unto itself or as a variant of well differentiated squamous cell carcinoma is controversial. To contribute new insights into the biological behavior of this rare tumor, we applied DNA flow cytometry to three node-negative verrucous carcinomas of the oral cavity. All tumors expressed a single aneuploid cell population. One of the patients experienced three courses with local recurrence. All secondary tumors retained the initially established aneuploid clone. The development of aneuploidy is thus a cytogenetic event common to both verrucous and squamous carcinoma of the oral cavity.
Hemmer
J
J
University of Ulm, Division of Tumor Biology, D-89070 Ulm, Germany.
Kraft
K
K
D000368:Aged; D000782:Aneuploidy; D018289:Carcinoma, Verrucous / Q000145:classification / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000145:classification / Q000235:genetics*; D012680:Sensitivity and Specificity
D004273:DNA, Neoplasm