NF-kappaB and the innate immune response.
In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-kappaB (NFkappaB). NF-kappaB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-kappaB have been clarified by gene inactivation and biochemical analysis.
Hatada
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Max-Delbrück-Center for Molecular Medicine, Berlin, 13122, Germany.
Krappmann
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D
Scheidereit
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D004789:Enzyme Activation; D051550:I-kappa B Kinase; D007113:Immunity, Innate; D016328:NF-kappa B / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D014774:Virulence / Q000276:immunology
D016328:NF-kappa B; D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase