The degradation of N,N',N"-triethylenephosphoramide in aqueous solutions: a qualitative and kinetic study.
The degradation of N,N',N"-triethylenephosphoramide (TEPA) in aqueous solutions has been investigated over a pH range of 3-14. Samples were analyzed using a gas chromatographic system with nitrogen/phosphorus selective detection. The degradation kinetics were studied as function of pH, sodium chloride concentration and temperature. The degradation of TEPA in buffers follows pseudo first order kinetics. The logk(obs)8 the methoxy derivative of TEPA was formed, as a consequence of the applied procedure.
van Maanen
R J
RJ
Department of Pharmaceutical Analysis, University of Utrecht, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands. m.j.vanmaanen@pharm.uu.nl
Tijhof
I M
IM
Damen
J M
JM
Zwikker
J W
JW
Beijnen
J H
JH
D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry*; D002849:Chromatography, Gas; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013852:Thiotepa / Q000737:chemistry; D013721:Triethylenephosphoramide / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D018906:Antineoplastic Agents, Alkylating; D012996:Solutions; D014867:Water; D013852:Thiotepa; D013721:Triethylenephosphoramide