title: Periventricular white matter hyperintensities on MRI: correlation with neuropathologic findings.
abstract: Periventricular white matter hyperintensities on postmortem magnetic resonance imaging (MRI) and myelin-stained frontal and parietal histologic sections were evaluated independently in 12 cases. There was a strong relationship between the extent of white matter hyperintensities on MRI and the extent of gross and microscopic changes seen in the white matter of myelin-stained sections, particularly in the frontal lobe. In this material, the extent of myelin rarefaction correlated with a 0- to 8-point white matter hyperintensity scale rating on MRI in the same brains.
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington 40536, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Snowdon
authors.forename: W R
authors.initials: WR
authors.lastname: Markesbery
mesh_terms: D000375:Aging / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002102:Cadaver; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018709:Statistics, Nonparametric