title: A noninvasive measure of physical maturity as a predictor of bone mass in children.
abstract: OBJECTIVE
  The purpose of this study was to describe the accumulation of whole body bone mass in a longitudinal study of prepubertal boys and girls using Roche's physical maturity index as a measure of developmental age.
  
  
  METHODS
  We measured 561 children (39% white, 61% African-American) from a suburban school district, representing an ethnically mixed, middle-class community adjacent to Detroit. Anthropometric measures taken for the present study included recumbent length (cm), stature (cm), weight (kg), whole body bone mineral content (WBBMC in g) and a noninvasive measure of physical maturity (PM%). PM% was calculated from published formulae derived from data from the Fels Longitudinal Study, using recumbent length, weight, midparental stature, age, and age- and gender-specific regression coefficients.
  
  
  RESULTS
  At average age 9.9 (+/-0.6) years, there were no significant gender differences in stature, recumbent length, weight, or WBBMC in either ethnic group. Average PM for girls was significantly greater than that for boys within each ethnic group. There were no significant ethnic differences in PM in either gender. Stature and WBBMC were significantly different in the two ethnic groups for both boys and girls. Regressions of WBBMC on PM and chronological age indicated that PM explained more of the variance in WBBMC than did age (r2 ranging from 0.28 to 0.75 for PM versus 0.01 to 0.06 for age). In the case of African-American boys, r2 was similar (0.09 for PM and 0.06 for age).
  
  
  CONCLUSIONS
  PM is a useful, noninvasive measure of developmental age that is significantly correlated with bone mass in children. Our study also indicates that PM is a better predictor of WBBMC than chronological age. Because PM can be calculated without using invasive and potentially expensive methods, PM may be useful in some clinical as well as research settings.
authors.affiliation: Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Nelson
authors.forename: D A
authors.initials: DA
authors.lastname: Barondess
mesh_terms: D000375:Aging; D001827:Body Height; D001835:Body Weight; D015519:Bone Density; D001846:Bone Development; D002648:Child; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010290:Parents; D012727:Sex Characteristics; D016683:Supine Position