Demonstration of testicular apoptosis in human male infertility states using a DNA laddering technique.
DNA laddering, morphometric analysis, and in-situ end labelling of testis biopsy tissue obtained from azoospermic or severely oligozoospermic men revealed increased apoptosis frequency, implicating a possible role of apoptosis in the pathogenesis of human male infertility.
Lin
W W
WW
Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
Lamb
D J
DJ
Lipshultz
L I
LI
Kim
E D
ED
D000328:Adult; D017209:Apoptosis; D001345:Autoradiography / Q000379:methods; D053938:DNA Fragmentation; D006801:Humans; D020287:In Situ Nick-End Labeling; D008297:Male; D009845:Oligospermia / Q000503:physiopathology*; D012708:Sertoli Cells / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000503:physiopathology*