[Comparative effectiveness of the use of hematological methods to analyze the procoagulant activity of biological materials].
Whether clinical hematological methods by employing two parameters: (plasma recalcification time (PRT) and activated partial thromboplastin time (ACTT) can be used to examine the procoagulant activity of the surface of biological materials was comparatively studied. The method PRT was shown to be sensitive and reproducible while ACTT failed to significantly record differences in the procoagulant activities of various materials. The authors chose the optimal protocol for evaluating the blood compatibility of biological materials: the surface area/plasma volume ratio is more than 150 cm2/ml, the incubation time of samples is no less than 180 sec at 37 degrees C and continuous mixing.
Nemets
E A
EA
Sevast'ianov
V I
VI
D001672:Biocompatible Materials / Q000009:adverse effects; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000502:physiology; D001780:Blood Coagulation Tests; D002118:Calcium / Q000097:blood; D002122:Calcium Chloride / Q000008:administration & dosage; D004548:Elasticity; D005069:Evaluation Studies as Topic; D005340:Fibrinogen / Q000502:physiology; D005898:Glass; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D010314:Partial Thromboplastin Time; D012680:Sensitivity and Specificity; D013499:Surface Properties; D013696:Temperature; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors
D001672:Biocompatible Materials; D001779:Blood Coagulation Factors; D007202:Indicators and Reagents; D005340:Fibrinogen; D002122:Calcium Chloride; D002118:Calcium