Current status of artemisinin and its derivatives as antimalarial drugs.
Artemisinin is a promising and a potent antimalarial drug, which meets the dual challenge posed by drug-resistant parasites and rapid progression of malarial illness. This review article focuses on the progress achieved during the last years in the production of artemisinin from Artemisia annua. The structure, biosynthesis and analysis of artemisinin and its mode of action are described. The review also focuses on clinical studies, toxicity studies, pharmacokinetics and activity of artemisinin related compounds. The production strategies including organic synthesis, extraction from plants, in vitro cultures and alternative strategies for enhancing the yields are also discussed.
Dhingra
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School of Biotechnology, Institute of Post Graduate Studies & Research, Jawaharlal Nehru Technological University, Mahaveer marg, Hyderabad, India.
Vishweshwar Rao
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K
Lakshmi Narasu
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D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D037621:Artemisinins; D006801:Humans; D012717:Sesquiterpenes / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology*
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin