title: Age-specific effects of noradrenergic alpha-2 agonist clonidine on the development of amygdaloid kindling in developing rats.
abstract: The effects of clonidine on the development of amygdaloid kindling were studied in rats of various ages (14, 21, 28 and 70 postnatal days). Administration of clonidine (0.2, 0.5 mg/kg i.p.) caused a significant retardation of kindling development in the 28-day-old rats as well as in the adult rats, whereas, in the 14-day-old rats, the development of kindling was significantly facilitated by clonidine. No significant effect of clonidine was observed in the 21-day-old rats. These results indicate that in rats the effects of clonidine on the development of amygdaloid kindling vary during development.
authors.affiliation: Department of Neuropsychiatry, Faculty of Medicine, Tottori University, 86, Nishi-machi, Yonago, Japan. shiyoshi@grape.med.tottori-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Yoshioka
authors.forename: H
authors.initials: H
authors.lastname: Mitani
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: S
authors.initials: S
authors.lastname: Takeo
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Katayama
authors.forename: R
authors.initials: R
authors.lastname: Mizukawa
authors.forename: R
authors.initials: R
authors.lastname: Kawahara
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects*; D000679:Amygdala / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000316:Adrenergic alpha-Agonists; D000927:Anticonvulsants; D003292:Convulsants; D003000:Clonidine