Developmental dependency of Meissner corpuscles on trkB but not trkA or trkC.
The distribution of S100-immunoreactive (ir) corpuscular endings was examined in the palate of wildtype and knockout mice for trkA, trkB or trkC. In wildtype mice, S100-ir corpuscular endings were abundant at the top of palatal rugae. The endings contained 2-4 parallel arrays of S100-ir neurites. The distribution of S100-ir nerve endings in trkA and trkC knockout mice was similar to that in wildtype mice; S100-ir corpuscular endings were abundant in palates of the mutant mice. In trkB knockout mice, the palate was devoid of corpuscular endings, An immunoelectron microscopic method indicated that S100-ir corpuscular endings were identical to Meissner corpuscles. The normal development of Meissner corpuscles is probably dependent on trkB but not trkA or trkC.
Ichikawa
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H
Second Department of Oral Anatomy and Biodental Research Center, Okayama University Dental School, Japan.
Matsuo
S
S
Silos-Santiago
I
I
Sugimoto
T
T
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D005455:Fluorescent Antibody Technique; D008465:Mechanoreceptors / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D016253:Microscopy, Immunoelectron; D016501:Neurites / Q000378:metabolism / Q000648:ultrastructure; D010159:Palate / Q000166:cytology* / Q000294:innervation; D020917:Receptor, trkA / Q000502:physiology / Q000648:ultrastructure*; D020813:Receptor, trkB / Q000502:physiology / Q000648:ultrastructure*; D020812:Receptor, trkC / Q000502:physiology / Q000648:ultrastructure*; D009418:S100 Proteins / Q000032:analysis* / Q000172:deficiency; D012583:Schwann Cells / Q000378:metabolism / Q000648:ultrastructure; D011984:Sensory Receptor Cells / Q000378:metabolism / Q000648:ultrastructure
D015415:Biomarkers; D009418:S100 Proteins; D020917:Receptor, trkA; D020813:Receptor, trkB; D020812:Receptor, trkC