title: Neuroprotection due to irrigation during bipolar cautery.
abstract: OBJECTIVE
  To test whether irrigation during bipolar cautery confers thermoprotection from neuronal injury.
  
  
  METHODS
  A rat animal model (15 rats for each treatment group) was used to test the thermoprotective effects of irrigation during bipolar cautery. In this model, the sciatic nerve was exposed, and a 1-second stimulus was applied using bipolar cautery forceps at 40 or 20 W placed directly on the nerve in the presence or absence of simultaneous irrigation. The effects of cautery were determined on the basis of clinical gait analysis by means of the Sciatic Functional Index, temperature response, and neuropathological findings.
  
  
  RESULTS
  The degree of paresis was reduced with irrigation. Neuropathological examination of the sciatic nerve after cautery showed significant axonal loss (more small than large fibers) with concomitant demyelination, which was partially inhibited by irrigation (chi2; P = .04). The mechanism of thermoprotection by irrigation was not the result of a reduction in the temperature spike that followed cautery, but resulted from a reduced temperature response during the 15 seconds that followed 40- or 20-W stimulation with bipolar cautery.
  
  
  CONCLUSIONS
  Simultaneous irrigation and bipolar cautery enhance temperature recovery to basal levels and protect the peripheral nerve from the effects of cautery.
authors.affiliation: Department of Otolaryngology, Loyola University Stritch School of Medicine, Maywood, Ill, USA.
authors.forename: J
authors.initials: J
authors.lastname: Donzelli
authors.forename: J P
authors.initials: JP
authors.lastname: Leonetti
authors.forename: R D
authors.initials: RD
authors.lastname: Wurster
authors.forename: J M
authors.initials: JM
authors.lastname: Lee
authors.forename: M R
authors.initials: MR
authors.lastname: Young
mesh_terms: D000818:Animals; D002056:Burns / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004564:Electrocoagulation / Q000009:adverse effects* / Q000379:methods; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries* / Q000473:pathology / Q000601:surgery; D013696:Temperature; D007507:Therapeutic Irrigation