[Comparative study of tetracycline-estrone and estrone effects on bone histomorphometric parameters in ovariectomized rats].
OBJECTIVE
To compare the effects of tetracycline-estrone (TE) and estrone (E) on bone histomorphometric parameters of femoral distal diaphysis in ovariectomized (OVX) rats.


METHODS
Twenty female rats were randomly allocated into four groups, 5 rats in each: tetracycline-estrone (TE), estrone (E), OVX and sham operation (S). The OVX rats were used as a model for osteoporosis. After being fed with TE or E for 13 weeks, all rats were sacrificed. The effects of TE and E on bone microarchitecture and dynamics were studied by bone histomorphometry.


RESULTS
The histomorphometric data showed that the connectivity of trabecular bone in TE and E groups was significantly improved in comparision with that in S group (P < 0.05). The dynamic data indicated that in TE and E group, the tetracycline labelled and osteoid surfaces were remarkably increased in comparision with those in OVX group, especially the data in TE group were significantly higher than those in E group and other two groups (P < 0.05).


CONCLUSIONS
The connectivity of trabecular bone could be significantly improved by both TE and E. The activation frequency seemed to be higher in TE group than that in E group.
Lu
B
B
General Hospital, Tianjin Medical University.
Qiu
M
M
Zheng
H
H
D000818:Animals; D015519:Bone Density; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D005269:Femur; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013752:Tetracycline
D004970:Estrone; D013752:Tetracycline