Anticonvulsant activity of analogues of acetazolamide.
The anticonvulsant activity of 5-tertbutyloxycarbonylamido-1,3,4-thiadiazole-2-sulfonamide (B-H2ats) and 5-amino-1,3,4-thiadiazole-2-sulfonamide (Hats) was compared in mice, to that of acetazolamide (H2acm). These compounds exhibit potent anticonvulsant activity and low minimal motor impairment.
Chufán
E E
EE
Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina.
Pedregosa
J C
JC
Baldini
O N
ON
Bruno-Blanch
L
L
D000086:Acetazolamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*; D013830:Thiadiazoles / Q000737:chemistry / Q000494:pharmacology*
C404739:5-tert-butyloxycarbonylamido-1,3,4-thiadiazole-2-sulfonamide; D000927:Anticonvulsants; D013449:Sulfonamides; D013830:Thiadiazoles; C404727:5-amino-1,3,4-thiadiazole-2-sulfonamide; D000086:Acetazolamide