Farnesyltransferase inhibitor-induced regression of mammary tumors in TGF alpha and TGF alpha/neu transgenic mice correlates with inhibition of map kinase and p70s6 kinase phosphorylation.
Nørgaard
P
P
Vanderbilt Cancer Center, Vanderbilt University, Nashville, Tennessee 37232, USA. norgaard@forum.dk
Law
B K
BK
Plovisson
H S
HS
Moses
H L
HL
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D051231:Farnesyltranstransferase; D018734:Genes, erbB-2; D008325:Mammary Neoplasms, Experimental / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008822:Mice, Transgenic; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010766:Phosphorylation; D019893:Ribosomal Protein S6 Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015291:Transforming Growth Factors / Q000235:genetics*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D015291:Transforming Growth Factors; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase; D019893:Ribosomal Protein S6 Kinases; D020928:Mitogen-Activated Protein Kinases