[Study on the preventive effect of tea on DNA damage of the buccal mucosa cells in oral leukoplakias induce by cigarette smoking].
In order to study the preventive effect of tea on DNA damage induced by cigarette smoking and to provide further evidence on the protective effects of tea in human cancer, a 6-month, double-blind and randomized placebo-controlled intervention trial was carried out. The effect of tea on micronuclei frequency in exfoliated oral buccal mucosa cells in 36 oral leukoplakias of smokers was investigated. A kind of mixed tea given in an oral dose of 3 g/day and a concentration of 0.1% smeared on mucosa lession three times a day for 3 months and 6 months, significantly decreased the micronuclei formation in exfoliated oral buccal mucosa cells in subjects with oral leukoplakias. In contrast, there was no change in the micronuclei frequency after 6 months in the placebo group. The results indicate that mixed tea may reduce the oral cancer risk by preventing DNA damage in oral leukopiakias induced by cigarette smoking.
Li
N
N
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China.
Sun
Z
Z
Liu
Z
Z
Han
C
C
D000328:Adult; D004249:DNA Damage / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D010936:Plant Extracts / Q000494:pharmacology; D012907:Smoking / Q000009:adverse effects*; D013662:Tea
D010936:Plant Extracts; D013662:Tea