Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.
When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p<0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p<0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.
O'Doherty
J
J
Department of Experimental Psychology, University of Oxford.
Rolls
E T
ET
Francis
S
S
Bowtell
R
R
McGlone
F
F
Kobal
G
G
Renner
B
B
Ahne
G
G
D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D006179:Gyrus Cinguli / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D010936:Plant Extracts / Q000494:pharmacology; D017397:Prefrontal Cortex / Q000502:physiology; D012201:Reward; D012528:Satiety Response / Q000187:drug effects / Q000502:physiology*; D012903:Smell / Q000187:drug effects / Q000502:physiology*
D010936:Plant Extracts