title: Follow-up of patients with unexplained infertility who previously underwent natural cycle in vitro fertilization.
abstract: One hundred and seventeen couples with unexplained infertility who underwent natural cycle in vitro fertilization (NIVF) in the years 1991-1993 at the Sheffield Fertility Centre (SFC) formed the basis of this analysis, where they were followed in the following years. Seventy-six of the 117 patients who did not conceive came back for further treatment and they were offered either stimulated intrauterine insemination (SIUI) or stimulated in vitro fertilization (SIVF). If fertilization was confirmed at NIVF they then received SIUI for three treatment cycles and a change to SIVF treatment. If fertilization was not confirmed at NIVF they were then subjected to SIVF. Only 41 patients out of 117 (35%) did not come back for further treatment. The remaining 76 patients (65%) had 130 cycles of treatment, 58 cycles of SIUI and 72 cycles of SIVF. An implantation rate of 23.4% per cycle completed was achieved in the SIUI group. The rate of implantation for the SIVF group was 19.4% per cycle completed. We conclude that patients with unexplained infertility who failed fertilization at NIVF showed fertilization and implantation at SIVF and SIUI, and the implantation rate was similar in both groups.
authors.affiliation: Jordan University of Science and Technology, Jordan and Sheffield Fertility Centre and University Department of Obstetrics and Gynaecology, Jessop Hospital for Women, Sheffield, UK. fhmzayed@just.edu.jo
authors.forename: F
authors.initials: F
authors.lastname: Zayed
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D011247:Pregnancy / Q000706:statistics & numerical data*; D011336:Probability; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D017211:Treatment Failure; D016896:Treatment Outcome