title: Reproducibility of magnetization transfer ratio histogram-derived measures of the brain in healthy volunteers.
abstract: Using two MR scanners, we evaluated the intraobserver, interobserver, image-reimage, and interimager variabilities in the assessment of magnetization transfer ratio (MTR) histograms obtained monthly on four occasions from five healthy volunteers. With multiple observers, the mean coefficients of variations ranged from 2.2% to 8.2% for "pure" image-reimage variability, from 1.2% to 4.9% for interobserver variability, and from 2.1% to 4.9% for image-reimage variability. The mean intraobserver coefficients of variations were always lower than 1%. The mean coefficients of variations ranged from 10.2% to 14.6% for pure interimager variability and from 8.6% to 14.3% for interimager variability with multiple observers. Interimager variability accounted for 96.0% of the overall variability of average MTR, for 96.7% of peak location, and for 41.1% of the peak height. The use of different MR scanners is the main source of variability when obtaining MTR histograms.
authors.affiliation: Department of Neuroscience, Scientific Institute Ospedale San Raffaele, University of Milan, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Sormani
authors.forename: G
authors.initials: G
authors.lastname: Iannucci
authors.forename: M A
authors.initials: MA
authors.lastname: Rocca
authors.forename: G
authors.initials: G
authors.lastname: Mastronardo
authors.forename: M
authors.initials: M
authors.lastname: Cercignani
authors.forename: L
authors.initials: L
authors.lastname: Minicucci
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D012016:Reference Values; D015203:Reproducibility of Results