Cernuosides A and B, two sucrase inhibitors from Pulsatilla cernua.
Two oleanane-type oligoglycosides, cernuosides A (1) and B (2), were isolated from the roots of Pulsatilla cernua (Ranunculaceae). Structure elucidation was accomplished by 1D and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, and ROESY) methods, FABMS, and hydrolysis. Both compounds showed moderate activity against sucrase.
Zhang
Q
Q
Department of Phytochemistry, China Pharmaceutical University, Nanjing, People's Republic of China.
Ye
W
W
Yan
X
X
Zhu
G
G
Che
C T
CT
Zhao
S
S
D000818:Animals; D002240:Carbohydrate Sequence; D002681:China; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013393:Sucrase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D006027:Glycosides; C406770:cernuoside A; C406771:cernuoside B; D009828:Oleanolic Acid; D013393:Sucrase