[Effect of tobacco smoke on the level of estrogens and DNA in the rat uterus].
Tobacco smoke induced no changes in the rat uterus weight or in oestrus cycle but decreased estradiol (E2) concentration in the uterus tissue and increased and later decreased the proliferation index and percentage of the cells in the S-phase. The data obtained suggest a phasic character of changes in the reproductive system under the effect of tobacco smoke and corroborate the concept of the role of smoking in the shifting the type of hormonal carcinogenesis from promotional to genotoxic one.
Bershteĭn
L M
LM
N. N. Petrov Institute of Oncology, St. Petersburg, Russia.
Tsyrlina
E V
EV
Gamaiunova
V B
VB
Bychkova
N V
NV
Kriukova
O G
OG
Dzhumasultanova
S V
SV
Kolesnik
O S
OS
Kovalenko
I G
IG
Zimarina
T S
TS
D000375:Aging; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D008938:Mitosis; D009929:Organ Size; D010947:Plants, Toxic; D051381:Rats; D012906:Smoke / Q000009:adverse effects*; D013997:Time Factors; D014026:Nicotiana; D014599:Uterus / Q000378:metabolism* / Q000473:pathology
D004967:Estrogens; D012906:Smoke; D004247:DNA