Use of 99mTc-mercaptoacetyltriglycine to evaluate renal function in horses.
Ten healthy horses were injected intravenously with 99mTc-MAG3 and the disappearance of radioactivity from the blood was measured. The total body clearance (Cl(B)) and elimination half-life (t1/2(beta)) were 7.9 +/- 1.5 ml/kg/minute and 32.8 +/- 4.1 minutes, respectively. The disappearance of 99mTc-MAG3 from the blood of 2 horses with compromised renal function was also measured. The data suggest that 99mTc-MAG3 is a useful and clinically applicable radiopharmaceutical for measurement of effective renal blood flow in the horse.
Woods
P R
PR
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, USA.
Drost
W T
WT
Clarke
C R
CR
Rodebush
C J
CJ
D000818:Animals; D003092:Colitis / Q000382:microbiology / Q000662:veterinary; D005260:Female; D005500:Follow-Up Studies; D006207:Half-Life; D006734:Horse Diseases / Q000000981:diagnostic imaging; D006736:Horses / Q000502:physiology*; D006869:Hydronephrosis / Q000662:veterinary; D007275:Injections, Intravenous; D007668:Kidney / Q000000981:diagnostic imaging* / Q000502:physiology; D007669:Kidney Calculi / Q000662:veterinary; D008297:Male; D008657:Metabolic Clearance Rate; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000097:blood; D017597:Renal Blood Flow, Effective / Q000502:physiology; D051437:Renal Insufficiency / Q000000981:diagnostic imaging / Q000662:veterinary; D012206:Rhabdomyolysis / Q000662:veterinary; D012481:Salmonella Infections, Animal / Q000150:complications; D017263:Technetium Tc 99m Mertiatide / Q000008:administration & dosage / Q000097:blood
D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide