Preparative chromatographic resolution of enantiomers using polar organic solvents with polysaccharide chiral stationary phases.
The preparative chromatographic resolution of racemic mixtures is rapidly becoming a standard approach for the generation of enantiomers in pharmaceutical research and development. This paper will discuss the optical resolution of numerous pharmaceutical intermediates and final products using polar organic solvents with polysaccharide chiral stationary phases. The advantages of this approach compared to more traditional mobile phases for preparative separations will be presented. In addition the ability to reverse elution order using polar organic solvents will be presented.
Miller
L
L
Chemical Sciences Department, Searle, Skokie, IL 60077, USA. lawrence.m.miller@monosanto.com
Orihuela
C
C
Fronek
R
R
Murphy
J
J
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D011134:Polysaccharides; D012997:Solvents; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations; D011134:Polysaccharides; D012997:Solvents