Factors influencing resistance to reinfection with Plasmodium falciparum.
A treatment-reinfection study design was used to investigate the relationships between host immunologic and/or genetic factors and resistance to reinfection with Plasmodium falciparum. Sixty-one children in Gabon were enrolled in a cross-sectional study to measure the prevalence of each human plasmodial species. All were given amodiaquine for radical cure of parasites, and 40 were subsequently followed-up for 30 weeks. Successive blood smears were examined to measure the delay of reappearance in blood of asexual stages of P. falciparum parasites. Presence of infection during the cross-sectional survey was associated with male sex, non-deficient glucose-6-phosphate dehydrogenase activity, plasma interleukin-10 level, and anti-LSA-Rep antibody concentration. Resistance to reinfection was related to the presence of anti-LSA-J antibodies, and the absence of anti-LSA-Rep antibodies. Moreover, P. malariae-infected subjects were usually co-infected with P. falciparum, and were also more rapidly reinfected with P. falciparum after treatment, compared with those without P. malariae infection.
Domarle
O
O
Centre International de Recherches Mécicales de Franceville, Gabon.
Migot-Nabias
F
F
Mvoukani
J L
JL
Lu
C Y
CY
Nabias
R
R
Mayombo
J
J
Tiga
H
H
Deloron
P
P
D000293:Adolescent; D000328:Adult; D000655:Amodiaquine / Q000627:therapeutic use; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000962:Antimalarials / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005681:Gabon / Q000453:epidemiology; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D010963:Plasmodium falciparum / Q000276:immunology* / Q000302:isolation & purification; D010965:Plasmodium malariae / Q000302:isolation & purification; D015995:Prevalence; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
D000913:Antibodies, Protozoan; D000962:Antimalarials; D000655:Amodiaquine