Antidepressant options in primary care.
This article summarizes the basic and clinical pharmacology of the available antidepressants to aid the busy primary care practitioner in anticipating and predicting the effects of different antidepressants on patients; choosing a specific antidepressant for each patient based on these effects; selecting a sequential antidepressant for the patient who has not benefited from a trial of a specific type of antidepressant, either because of inadequate effect or treatment-limiting adverse effects; and avoiding adverse drug interactions when choosing an antidepressant for patients on other drug therapy.
Preskorn
S H
SH
Department of Psychiatry, University of Kansas School of Medicine, Wichita, USA.
D000928:Antidepressive Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy*; D004341:Drug Evaluation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D011320:Primary Health Care; D013375:Substance Withdrawal Syndrome / Q000473:pathology
D000928:Antidepressive Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System