title: [Venous thromboembolism in pregnancy].
abstract: A DUAL CHALLENGE: Pregnancy is a physiological state favoring the development of venous thromboembolism and sometimes discloses a coagulation disorder. Due to the presence of the fetus, suspected venous thromboembolism in a pregnant woman raises a dual challenge for the clinician: confirmation of the clinically suspected diagnosis using imaging techniques exposing the fetus to as little radiation as possible, and adapted anticoagulant therapy taking into account the teratogenic risk.
  Excepting exceptionally severe cases, the only validated long-term treatment is continuous infusion heparin. However, because of the difficulties inherent in the use and control of this type of administration, most clinicians prefer low-molecular-weight heparins (LMWH) although these pharmaceutical products have not acquired official approval for this indication.
  
  
  CONCLUSIONS
  The optimal therapeutic approach for prevention of venous thromboembolism in a pregnant woman with an acquired or hereditary coagulation disorder or a history of venous thromboembolism remains to be defined. New clinical trials are needed to validate the use of LMWH in this indication and determine the therapeutic approach in certain risk situations and at delivery.
authors.affiliation: Service de Cardiologie, Hôpital d'Instruction des Armées Ste Anne, Toulon. fplaurent@yahoo.com
authors.forename: P
authors.initials: P
authors.lastname: Laurent
authors.forename: G
authors.initials: G
authors.lastname: Cellarier
authors.forename: A
authors.initials: A
authors.lastname: Cugulière
authors.forename: J
authors.initials: J
authors.lastname: Bonal
authors.forename: C
authors.initials: C
authors.lastname: Bouchiat
authors.forename: P
authors.initials: P
authors.lastname: Talard
authors.forename: G V
authors.initials: GV
authors.lastname: Dussarat
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy; D011296:Prenatal Diagnosis; D011379:Prognosis; D012307:Risk Factors; D013923:Thromboembolism / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000517:prevention & control / Q000628:therapy
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight