Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A4 into leukotriene B4.
Andberg
M
M
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Hamberg
M
M
Haeggström
J Z
JZ
D000818:Animals; D020134:Catalytic Domain / Q000235:genetics; D004851:Epoxide Hydrolases / Q000235:genetics / Q000378:metabolism*; D006868:Hydrolysis; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis / Q000737:chemistry; D066298:In Vitro Techniques; D007700:Kinetics; D017572:Leukotriene A4 / Q000737:chemistry / Q000378:metabolism*; D007975:Leukotriene B4 / Q000096:biosynthesis* / Q000737:chemistry; D051379:Mice; D016297:Mutagenesis, Site-Directed; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D013237:Stereoisomerism
D006893:Hydroxyeicosatetraenoic Acids; D017572:Leukotriene A4; D011994:Recombinant Proteins; D007975:Leukotriene B4; D004851:Epoxide Hydrolases; C043134:leukotriene A4 hydrolase