title: A new bioactive triene aldehyde from the marine sponge Leucetta microraphis.
abstract: A new triene aldehyde, (2E,6Z,9Z)-2-methyl-2,6,9-icosatrienal (1), was isolated from a MeOH extract of the Okinawan marine sponge Leucetta microraphis. The structure of 1 was determined by spectroscopic analysis. Three imidazole alkaloids, leucettamine B, preclathridine A, and (9E)-clathridine 9-N-(2-sulfoethyl)imine, were also obtained and identified. Compound 1 showed moderate growth-inhibitory activity toward HeLa S3 cells.
authors.affiliation: Laboratory of Bioorganic Chemistry, School of Life Science, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Tsuda
authors.forename: M
authors.initials: M
authors.lastname: Iwashima
authors.forename: K
authors.initials: K
authors.lastname: Iguchi
mesh_terms: D000447:Aldehydes / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006367:HeLa Cells; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: C406638:2-methyl-2,6,9-icosatrienal; D000447:Aldehydes; D000970:Antineoplastic Agents