title: Neuromagnetic localization of CMV generators using incomplete and full-head biomagnetometer.
abstract: Contingent magnetic variation (CMV) data were recorded in three healthy male subjects using a 2 x 37 biomagnetometer system. The experiment was repeated for one of the subjects using a 151 whole-head biomagnetometer; the same auditory GO/NOGO choice reaction time paradigm as in the first experiment was used, extended to include repetitions of identical runs and additional control conditions. Magnetic field tomography was applied to the averaged data of each subject, for each run and condition (e.g., GO/NOGO). An independent estimate of the current density in the brain was obtained every few milliseconds. The slow components were emphasized by integrating the square of the current density vector, pixel by pixel, revealing in each subject activity in the auditory cortex, sensorimotor cortex, inferior prefrontal area, and posterior inferior parietal area. The intersubject variability was large, but looking across subjects the auditory and sensorimotor cortex (which were best covered by the two probes) were consistently identified in each subject as contributing to the generation of the early and late slow CMV components. These findings were confirmed by the whole-head single-subject experiment, in which slow activity was also identified in the supplementary motor area (SMA) and posterior cingulate cortex (PCC), areas very likely missed in the first experiment because of the limited view of the twin system. The PCC and particularly the SMA activations were substantially reduced when identical runs were repeated.
authors.affiliation: Department of Physics, Institute of Medicine Research Centre Jülich, Jülich, 52425, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Dammers
authors.forename: A A
authors.initials: AA
authors.lastname: Ioannides
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D004574:Electromagnetic Fields; D006801:Humans; D008280:Magnetics; D008297:Male