[Behavioral-teratological effects of caffeine on mice].
Pregnant ICR mice were exposed to caffeine at levels of 0, 4, 20 and 100 mg/kg during pregnancy. The behavioral-teratological tests indicated that the retardation of development, the obstruction of early reflexes and sensation and decline of learning ability existed in the offsprings of 20 and 100 mg/kg groups. The number of the dead fetus increased in the group of 100 mg/kg coffeine treated mice. No morphological changes were found.
Yin
W
W
Hengyang Hygiene and Antiepidemic Station, China.
Li
H
H
Peng
L
L
D000818:Animals; D002110:Caffeine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development; D005260:Female; D008431:Maternal-Fetal Exchange; D018782:Maze Learning; D051379:Mice; D008813:Mice, Inbred ICR; D019957:Motor Skills Disorders / Q000139:chemically induced*; D011247:Pregnancy
D002110:Caffeine