title: Simulated torsade de pointes--the role of conduction defects and mechanism of QRS rotation.
abstract: A possible mechanism of torsade de pointes consisting of moving sites of reentry in the presence of disparate recovery of excitability has been previously proposed. This study evaluates the role of conduction defects in that mechanism. A computer model that simulated propagation, cycle length dependent recovery of excitability, and slow propagation during incomplete recovery and in conduction defects was used. Localized conduction defects consisting of slow propagation were shown to allow reentry at changing locations in the presence of uniform recovery properties. Later activation within defects resulted in later recovery, which permitted independent antegrade propagation adjacent to the defects. Retrograde propagation in the defects then resulted in reentry. The location of serial reentry changed because retrograde propagation and antegrade recovery had opposing directions and met distal to the origin of antegrade excitation. This mechanism was similar to that produced by disparate recovery and the combination of conduction defects and disparate recovery permitted the mechanism to occur with less marked disparity than otherwise required. The study also showed bidirectional serial reentry around a localized conduction defect or region of disparate recovery, which resulted in rotation of QRS peaks around the isoelectric line. The study provided evidence that either conduction defects or disparate recovery of excitability may be a substrate for torsade de pointes. It also indicated that combination of these factors might permit torsade de pointes when neither alone does so. This provides a possible explanation for the special propensity of quinidine and other drugs that slow conduction as well as prolong recovery to result in torsade de pointes. Findings also suggested a more explicit mechanism for rotation of QRS peaks about the electrocardiogram baseline than was previously available.
authors.affiliation: Nora Eccles Harrison Cardiovascular Research and Training Institute and the Division of Cardiology, University of Utah, Salt Lake City 84112-5000, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Abildskov
authors.forename: R L
authors.initials: RL
authors.lastname: Lux
mesh_terms: D003198:Computer Simulation; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D016171:Torsades de Pointes / Q000209:etiology* / Q000503:physiopathology