Evaluation of carcinogenic and co-carcinogenic potential Quinalphos in mouse skin.
Quinalphos [O,O-diethyl-O-quinoxalinyl-phosphorothidate] is an organophosphorus pesticide with tremendous utility in mixed pest control due to its insecticidal and acaricidal properties. Apart from its pesticidal property, Quinalphos is known to induce various toxic effects in nontarget species and experimental animals. No studies have been conducted to evaluate the carcinogenic/co-carcinogenic hazards associated with Quinalphos exposure. In the present set of investigations, the tumorigenic potential of Quinalphos has been evaluated following topical exposure in Swiss albino mice. Long-term animal bioassays conducted for the evaluation of complete carcinogenic, tumour-initiating and tumour-promoting potential of Quinalphos revealed that it has only tumour-initiating potential at a dose of 10 mg/kg body weight (b.wt.), in the two-stage mouse skin model of carcinogenesis. Quinalphos exposure failed to produce neoplasia when tested for complete carcinogenic activity at all three tested dose levels or tumour promoting activity.
Shukla
Y
Y
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India. yshukla@itrc.sirnetd.ernet.in
Singh
A
A
Mehrotra
N K
NK
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000633:toxicity; D000287:Administration, Topical; D000505:Alopecia / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D003043:Cocarcinogenesis; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D007306:Insecticides / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D051379:Mice; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D012883:Skin Ulcer / Q000139:chemically induced; D013755:Tetradecanoylphorbol Acetate / Q000008:administration & dosage / Q000633:toxicity
D002273:Carcinogens; D007306:Insecticides; D009946:Organothiophosphorus Compounds; C009145:quinalphos; D015127:9,10-Dimethyl-1,2-benzanthracene; D013755:Tetradecanoylphorbol Acetate