Indinavir concentrations and St John's wort.
St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.
Piscitelli
S C
SC
Burstein
A H
AH
Chaitt
D
D
Alfaro
R M
RM
Falloon
J
J
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004351:Drug Resistance; D005260:Female; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D006801:Humans; D020902:Hypericum / Q000009:adverse effects*; D019469:Indinavir / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal; D017211:Treatment Failure
D017320:HIV Protease Inhibitors; D019469:Indinavir