Synthesis of an alpha-(2,3)-Sialylated, Complex-Type Undecasaccharide.
Only two building blocks were necessary to provide efficient access to the complex undecasaccharide 1 by means of two stereo- and regioselective glycosylation reactions. Stereocontrolled p-methoxybenzyl-assisted beta-mannosylation afforded the critical beta-mannoside linkage in 1, which is a constituent of the human glycoproteins follitropin and gonadotropin.
Seifert
J
RIKEN (The Institute of Physical and Chemical Research) and CREST Japan Science and Technology Corporation (JST) Hirosawa 2 - 1, Wako-Shi, Saitama, 351-0198 (Japan).
Lergenmüller
M
Ito
Y