[The effect of partial hepatectomy and portal vein occlusion on aminopyrine metabolism capacity of the liver in rats].
To observe the variation of metabolic function and anatomical weight of the liver after partial hepatectomy and occlusion of portal branches feeding the same magnitude of the liver lobes, hepatic 14C-aminopyrine demethylation capacity determined by aminopyrine breath test and liver weight in rats were examined and compared in series in this study. The results showed that 14CO2 expiratory clearance rate was reduced by 50% at 2 hours and by 70% at 24 hours after 70% hepatectomy. Then it increased gradually and was similar to the preoperative level in 2 weeks. The remnant liver weight was lowest at 2 hours and increased to 80% of the control in 7 days after 70% hepatectomy. It recovered to normal in 2 weeks. In 90% hepatectomy group, 14CO2 expiratory clearance rate decreased by 90% at 2 hours after operation. Thereafter, all rats died very soon. In the 2 portal vein occlusion groups, 14CO2 expiratory clearance rate had little change at 2 hours and it declined by about 40% at 24 hours after ligation of portal branches feeding 70% or 90% liver mass. It recovered gradually and returned to the preoperative level in 2 weeks. The total liver weight in 2 portal occlusion groups was not significantly different from that in the control except that it was slightly lower than the control at 24 hours after operation. This experimental study suggests that comparing deprivation of portal blood feeding partial liver mass with corresponding partial hepatectomy, the former can not only keep the anatomical liver weight relatively stable but also produce a lesser damage to hepatic metabolic function.
Li
B
B
Department of Surgery, First Affiliated Hospital, Chengd.
Qin
Y
Y
Saliez
A
A
Lambott
L
L
D000632:Aminopyrine / Q000378:metabolism*; D000818:Animals; D001944:Breath Tests; D006498:Hepatectomy / Q000379:methods; D008026:Ligation; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D011169:Portal Vein / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000632:Aminopyrine