title: Identification of deoxymiroestrol as the actual rejuvenating principle of "Kwao Keur", Pueraria mirifica. The known miroestrol may be an artifact.
abstract: Miroestrol (1) has been isolated previously as an active principle from "Kwao Keur" (Pueraria mirifica), a rejuvenating folk medicine from Thailand. Reinvestigation using bioassay-guided purification has resulted in the isolation of a new potent phytoestrogen, deoxymiroestrol (2). The facile aerial oxidation of 2 into 1 suggests the possibility that 1 may be an artifact.
authors.affiliation: Faculty of Pharmaceutical Sciences and Chemical Analysis Center, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Chansakaow
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Seki
authors.forename: K
authors.initials: K
authors.lastname: Sekine (née Yoshizawa)
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: C
authors.initials: C
authors.lastname: Chaichantipyuth
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins; D004354:Drug Screening Assays, Antitumor; D004968:Estrogens, Non-Steroidal / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013256:Steroids; D013785:Thailand; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D004968:Estrogens, Non-Steroidal; D013256:Steroids; C406602:deoxymiroestrol