title: New isomalabaricane triterpenes from the marine sponge Stelletta globostellata that induce morphological changes in rat fibroblasts.
abstract: Three new isomalabaricane triterpenes, 29-hydroxystelliferin D (2), 3-epi-29-hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with 0.2 microM of 2-4 exhibited unusual morphological characteristics, followed by death in 5 days.
authors.affiliation: Laboratory of Aquatic Natural Products Chemistry and Laboratory of Aquatic Molecular Biology and Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Oku
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: S i
authors.initials: Si
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Watabe
authors.forename: N
authors.initials: N
authors.lastname: Fusetani
mesh_terms: D000107:Acetylation; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004396:Coloring Agents; D005347:Fibroblasts; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity*
chemical_list: C406627:29-hydroxystelliferin D; C406629:3-epi-29-hydroxystelliferin A; C406628:3-epi-29-hydroxystelliferin E; D000970:Antineoplastic Agents; D004396:Coloring Agents; D013778:Tetrazolium Salts; D013844:Thiazoles; D014315:Triterpenes; C022616:thiazolyl blue