title: [Treatment of septic complications od secondary peritonitis].
abstract: The authors review the current management goals of surgical and antibiotic therapy in secondary peritonitis. Basic therapeutic regimen is the surgical elimination of the infectious source by means of a rational and risk-adapted operative procedure. Other technical procedures (such as intra- and postoperative lavage, drainage of the abdominal cavity, decompression, etc.) are critically reviewed and reduced to the scientific background. A calculated antibiotic therapy should be performed to eliminate the leading pathogens. The golden standard seems to be the short-term application of a third generation cephalosporin in combination with metronidazole. Antibiotic-induced endotoxinemia, bacterial shifting to grampositive species, and escalating antibiotic resistance require the examination of new therapeutic regimens (e.g. with quinolones).
authors.affiliation: Abteilung für Allgemein-, Thorax- und Gefässchirurgie, Krankenhauses Itzehoe.
authors.forename: G J
authors.initials: GJ
authors.lastname: Winkeltau
authors.forename: H
authors.initials: H
authors.lastname: Wolgast
authors.forename: U
authors.initials: U
authors.lastname: von Franqué
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000601:surgery; D006801:Humans; D010538:Peritonitis / Q000209:etiology* / Q000601:surgery; D011183:Postoperative Complications; D013530:Surgical Wound Infection / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents