Cytoprotection and intracellular calcium.
It seems that prostacyclin has an increasing effect on gastric mucosal (antral and fundic) calmodulin level in rats. Using either the calcium channel blocker verapamil or anti-calmodulin drugs (diazepam, trifluoperazine,) the cytoprotective effect of prostacyclin can be inhibited. Therefore, it is probable that calcium ions and calcium-activated calmodulin play a role in the effect of prostacyclin.
Balint
G A
GA
Laboratory of Clinical Pharmacology, Dept. of Psychiatry, Albert Szent-Györgyi Medical University, Szeged, Hungary.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology*; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019610:Cytoprotection / Q000187:drug effects / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D005748:Gastric Fundus; D005753:Gastric Mucosa / Q000166:cytology* / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D011706:Pyloric Antrum; D051381:Rats; D017208:Rats, Wistar; D014268:Trifluoperazine / Q000494:pharmacology; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002147:Calmodulin; D014268:Trifluoperazine; D014700:Verapamil; D011464:Epoprostenol; D003975:Diazepam; D002118:Calcium