[Study on inhibition and prevention of tumor and antioxidative effects of lithium carbonate in tumor bearing mice].
Two Kinds of tumor-bearing mice (hepatoma H22 and sarcoma S180) were administered with lithium carbonate (Li2CO3) for 17 or 10 days (advanced and simultaneous administration), in order to observe the effects of prevention and treatment of Li2CO3 on malignant tumor, as well as the relationship between Li2CO3 and lipid peroxidation in tumor-bearing mice. Meanwhile, we compared the toxic and side effects of cyclophosphamide (CP) with that of Li2CO3. The results showed that Li2CO3 had no significant toxic or side effects with the suggested doses. In the tests of inhibition and prevention of tumor, Li2CO3 could significantly inhibit the grouth of the two kinds of tumor, and increase the activity of superoxide dismutage (SOD) and decrease the contents of Malonyldialdehyde (MDA). In addition, Li2CO3 had no effect on the white blood cells (WBC) and decreased the micronucleus frequency (MNF) in bone marrow polychromatic erythrocytes (PCE), while CP had definite effect of decreasing the WBC and increasing the MNF in the tumor-bearing mice.
Zhang
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A
Department of Public Health, Guiyang Medical College, China.
Huang
X
X
Luo
P
P
Jiang
X
X
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D016651:Lithium Carbonate / Q000494:pharmacology* / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000097:blood / Q000517:prevention & control*; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D015162:Micronucleus Tests; D012510:Sarcoma 180 / Q000097:blood / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood
D000970:Antineoplastic Agents; D000975:Antioxidants; D016651:Lithium Carbonate; D008315:Malondialdehyde; D013482:Superoxide Dismutase