[Immunobiological significance of S-100 protein positive dendritic cells (S-100+DC) in patients with oral squamous cell carcinoma].
The purpose of this study is to investigate the role and clinical significance of S-100+DC in oral squamous cell carcinoma. Distribution of S-100+DC in the tumor tissues and regional lymph nodes (LN) of 60 patients with oral squamous cell carcinoma was detected by immunohistochemistry (ABC). The results showed that the S-100+DC density in tumor tissues was correlated with the tumor histologic grade (P < 0.05). The density of S-100+DC was significantly higher in regional LN without tumor than those with metastases (P < 0.05). However, there was no difference of S-100+DC in tumor tissues between patients with and without regional LN metastases. The distribution of S-100+DC in tumor tissues and regional LN could be considered as a reference indicator of tumor histologic grade and clinical prognosis of patients.
Deng
Y
Y
Department of Stomatology, First Teaching Hospital, Xinjiang Medical College, Urumqi.
Yuan
X
X
Chen
Z
Z
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000556:secondary; D003713:Dendritic Cells / Q000737:chemistry*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000737:chemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D009418:S100 Proteins / Q000032:analysis*
D009418:S100 Proteins