Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies.
The authors studied sera from 36 patients with Lambert-Eaton myasthenic syndrome (LEMS) by immunoblots using the recombinant protein derived from the DNA sequence encoding for the domain III S5-S6 linker of the P/Q-type voltage-gated calcium channel al subunit. The results of 18 patients were positive for antibodies to this recombinant protein. The results of 2 of 10 patients with lung cancer without LEMS were also positive.
Iwasa
K
K
Department of Neurology, Kanazawa University School of Medicine, Japan.
Takamori
M
M
Komai
K
K
Mori
Y
Y
D000906:Antibodies / Q000276:immunology*; D015220:Calcium Channels / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D009157:Myasthenia Gravis / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology*; D013577:Syndrome
D000906:Antibodies; D015220:Calcium Channels; D011994:Recombinant Proteins