title: Excessive apoptosis of bone marrow erythroblasts in a patient with autoimmune haemolytic anaemia with reticulocytopenia.
abstract: We report a patient with autoimmune haemolytic anaemia (AIHA) with reticulocytopenia, who showed excessive apoptosis of erythroblasts. Ultrastructural analysis of bone marrow cells showed that 50% of erythroblasts had characteristic features of apoptosis, which was confirmed by staining with Annexin-V. In addition, in contrast to normal erythroblasts, Ig staining of the entire erythroblast population could be shown. These data show that apoptosis may contribute to the mechanism of reticulocytopenia in AIHA.
authors.affiliation: Department of Hematology, Academisch Ziekenhuis Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. a.van.de.loosdrecht@int.azg.nl
authors.forename: A A
authors.initials: AA
authors.lastname: Van De Loosdrecht
authors.forename: D W
authors.initials: DW
authors.lastname: Hendriks
authors.forename: N R
authors.initials: NR
authors.lastname: Blom
authors.forename: J W
authors.initials: JW
authors.lastname: Smit
authors.forename: J T
authors.initials: JT
authors.lastname: De Wolf
authors.forename: E
authors.initials: E
authors.lastname: Vellenga
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000473:pathology*; D017209:Apoptosis; D004900:Erythroblasts / Q000473:pathology*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D012156:Reticulocytes; D013921:Thrombocytopenia / Q000473:pathology*