Increase of urocortin-like immunoreactivity in the supraoptic nucleus of Dahl rats given a high salt diet.
Urocortin-like immunoreactivity (Ucn-LI) in the supraoptic nucleus (SON) of Dahl rats was examined. Dahl salt-sensitive (S) rats fed with a high salt diet developed hypertension. Numbers of Ucn-LI neurons in the SON in Dahl S on a high salt diet were markedly increased, compared with those in Dahl salt-resistant (R) rats on the same. Sporadic Ucn-LI neurons were found in the SON of both Dahl S and R on a normal diet. Numbers of Ucn-LI neurons in the SON of spontaneously hypertensive rat (SHR) and stroke-prone SHR, genetic models of hypertension, and control rats (Sprague-Dawley and Wistar-Kyoto) were similar. These results suggest that Ucn in the SON is associated with salt loading-induced hypertension rather than spontaneous hypertension.
Hara
Y
Y
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Ueta
Y
Y
Isse
T
T
Serino
R
R
Shibuya
I
I
Hattori
Y
Y
Yamashita
H
H
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000187:drug effects* / Q000378:metabolism*; D004195:Disease Models, Animal; D006973:Hypertension / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D020303:Rats, Inbred Dahl; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*; D013495:Supraoptic Nucleus / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D054832:Urocortins
D017673:Sodium Chloride, Dietary; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone