Oxynitrilases for asymmetric C-C bond formation.
Oxynitrilases for the preparation of (R)- or (S)-cyanohydrins are now readily available. The research efforts of a number of groups have established these enzymes as catalysts with significant potential for application to asymmetric synthesis. Advances made in molecular cloning and genetics have delivered information on the oxynitrilase mechanism of action and sufficient quantities of enzyme to satisfy industrial requirements.
Johnson
D V
DV
Spezialforschungsbereich Biokatalyse, Institut für Organische Chemie der Technischen Universität Graz, Graz, A-8010, Austria.
Zabelinskaja-Mackova
A A
AA
Griengl
H
H
D000446:Aldehyde-Lyases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D002384:Catalysis; D003001:Cloning, Molecular; D003486:Cyanides / Q000737:chemistry
D003486:Cyanides; D000446:Aldehyde-Lyases; C021541:mandelonitrile lyase