[Study on multidrug resistant gene (MDR1) expression between neoplastic cells and peripheral blood lymphocytes in ovarian carcinoma].
OBJECTIVE
To explore the correlation of MDR1 (P-glycoprotein, P170) gene expression P170 contents among neoplastic tissues, peripheral blood lymphocytes (PBL) and ascites cancerous cells (ACC) during chemotherapy.


METHODS
Content of P170 in cancer tissue, ACC and PBL was quantiated dynamicly by using flow cytometric-immunologic method in 48 cases suffered from ovarian carcinoma.


RESULTS
Cancer tissue showed positive P170 in 25% of patients. During chemotherapy, P170 content in PBL and ACC were statistically increased. A significant correlation of P170 was found between PBL and ACC (0.01 < P < 0.05).


CONCLUSIONS
The results indicated that multidrug resistance was produced gradually during chemotherapy. Content of P170 in PBL could probably be used as an indirect index of multidrug resistance for recurrent carcinoma or residual tumor.
Yin
G
G
Department of Gyneacology and Obstetrics, Jinan Military General Hospital.
Chen
S
S
Sun
X
X
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis*; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics; D018284:Cystadenocarcinoma, Serous / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D019450:Genes, MDR; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000235:genetics*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1