[Protective effect of a new antiviral preparation of phosprenyl in experimental tick-borne encephalitis].
Antiviral activity of phosprenyl was studied in BALB/c mice infected with tick-borne encephalitis (TBE) virus. Up to 60% animals infected with TBE virus survived after 1-3 intramuscular injections of phosprenyl. The mortality in the untreated group infected with the virus was 100%. Direct antiviral effect of phosprenyl was studied in sensitive SPEV cells infected with TBE virus. The titer of the virus decreased 10-fold in the cells treated with the drug vs. untreated control cells. Phosprenyl stimulates some interleukins: gamma-interferon, tumor necrosis factor-alpha, and interleukin-6. The stimulating effect of the drug manifests in intact animals and in those infected with TBE virus and treated with phosprenyl. The prospects of further trials of the drug as a therapeutic and prophylactic agent in TBE are discussed.
Ozherelkov
S V
SV
Timofeev
A V
AV
Novikova
G P
GP
Deeva
A V
AV
Narovlianskiĭ
A N
AN
Sanin
A V
AV
Pronin
A V
AV
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016207:Cytokines / Q000096:biosynthesis; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D007273:Injections, Intramuscular; D051379:Mice; D008807:Mice, Inbred BALB C; D011106:Polyisoprenyl Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*
D000998:Antiviral Agents; D016207:Cytokines; D011106:Polyisoprenyl Phosphates; C105485:phosprenyl