title: [Clinical and therapeutical features in 135 patients with dystonia: experience of movement disorders unity of the Hospital de Clínicas of the Universidade Federal do Paraná].
abstract: This study aims to describe the clinical patterns and therapeutic responses in 135 patients with dystonia. According to the classification, 54% were focal; 17.8% were segmental; 8.1% hemidistonia; 18.6% generalized and 1.5% were multifocal. There was a positive familial history in 5.9% of the cases. The treatment of the idiopathic dystonias is divided in: specific and symptomatic, and it can be local with botulinum toxin, or systemic with oral drugs. The most common drugs used in the treatment were anticholinergics and benzodiazepines, with poor responses in the generalized forms. Botulinum toxin A was the first line treatment for focal and segmental forms of dystonia. Meanwhile, the generalized forms of dystonia show poor response to the therapies utilized.
authors.affiliation: Hospital de Clínicas da Universidade Federal do Paraná, Brasil. giorgiof@mandic.com.br
authors.forename: G
authors.initials: G
authors.lastname: Fabiani
authors.forename: H A
authors.initials: HA
authors.lastname: Teive
authors.forename: F
authors.initials: F
authors.lastname: Germiniani
authors.forename: D
authors.initials: D
authors.lastname: Sá
authors.forename: L C
authors.initials: LC
authors.lastname: Werneck
mesh_terms: D001569:Benzodiazepines / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D004421:Dystonia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D018680:Cholinergic Antagonists; D001569:Benzodiazepines; D001905:Botulinum Toxins