title: Influence of aging on thromboxane A2 and prostacyclin levels in rat hippocampal brain slices.
abstract: We have investigated the influence of age (3, 18, 24 months) on Thromboxane A2 (TXA2) and Prostacyclin (PGI2) levels in hippocampal slices from F344/NHSD rats. A significant increase in TXA2 and PGI2 levels was observed in 18 and 24 months old compared to 3 months old animals. A significant reduction in the ratio TXA2/PGI2 produced by a higher increase in PGI2 was observed in 24 month old animals. The reduction in the TXA2/PGI2 ratio has been related to vasodilatory and antiaggregating effects that may contribute to protect the brain against neuronal damage.
authors.affiliation: Unitat de Farmacologia.IDIBAPS.(Institut d'Investigacions Biomèdiques August Pi I Sunyer) Facultat de Medicina, Universitat de Barcelona, Casanova, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Marmol
authors.forename: P
authors.initials: P
authors.lastname: Puig-Parellada
authors.forename: J
authors.initials: J
authors.lastname: Sanchez
authors.forename: R
authors.initials: R
authors.lastname: Trullas
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D011464:Epoprostenol / Q000032:analysis*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013928:Thromboxane A2 / Q000032:analysis*; D013997:Time Factors
chemical_list: D013928:Thromboxane A2; D011464:Epoprostenol