title: Presence of p53 mutations in feline neoplasms.
abstract: A region from exon 4 to 8 of the tumour suppressor gene p53 was analysed in 60 feline tumours (30 fibrosarcomas, seven malignant histiocytomas, three lymphosarcomas, five basal cell tumours, five squamous cell carcinomas, two adenocarcinomas of tubular skin glands, one undifferentiated carcinoma of the skin, seven mammary carcinomas). Missense mutations were detected in two fibrosarcomas, one malignant fibrous histiocytoma, the undifferentiated carcinoma of the skin and one mammary carcinoma. One nonsense mutation was detected in one fibrosarcoma and one deletion/frameshift-mutation was observed in one squamous cell carcinoma.
authors.affiliation: Institute for Animal Breeding and Genetics, Veterinary University, Veterinärplatz 1, Vienna, A-1210, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Mayr
authors.forename: J
authors.initials: J
authors.lastname: Blauensteiner
authors.forename: A
authors.initials: A
authors.lastname: Edlinger
authors.forename: M
authors.initials: M
authors.lastname: Reifinger
authors.forename: K
authors.initials: K
authors.lastname: Alton
authors.forename: G
authors.initials: G
authors.lastname: Schaffner
authors.forename: G
authors.initials: G
authors.lastname: Brem
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000235:genetics* / Q000473:pathology; D002415:Cats; D003062:Codon; D004273:DNA, Neoplasm / Q000235:genetics; D005091:Exons; D005260:Female; D016368:Frameshift Mutation; D016158:Genes, p53; D008297:Male; D009154:Mutation; D020125:Mutation, Missense; D009369:Neoplasms / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction; D017384:Sequence Deletion
chemical_list: D003062:Codon; D004273:DNA, Neoplasm