[Metabolic effects of quinapril in hepertensive patients].
OBJECTIVE
The study of antihypertensive and metabolic effects of quinapril (accupro) in patients with essential hypertension (EH).


METHODS
Serum levels of cholesterol, its fractions and triglycerides were measured and standard glucose tolerance test was made in 40 EH patients before accupro therapy and 1 and 3 months after continuous accupro treatment (10-20 mg/day).


RESULTS
Antihypertensive effect of accupro was accompanied by marked improvement in carbohydrate and lipid metabolism in 28 patients. Normalization of blood pressure in the absence of negative effect of accupro on parameters of carbohydrate and lipid metabolism was recorded in 12 patients free of coexisting metabolic disorders.


CONCLUSIONS
The results of the trial allow to recommend antihypertensive treatment with accupro as effective both in patients with metabolic disorders and free of them.
Zonis
B Ia
BIa
Volkova
N I
NI
Martirosov
V Iu
VIu
Kharakhashian
A V
AV
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D007546:Isoquinolines / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008297:Male; D000077583:Quinapril; D044005:Tetrahydroisoquinolines; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood*
D000806:Angiotensin-Converting Enzyme Inhibitors; D015415:Biomarkers; D001786:Blood Glucose; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D014280:Triglycerides; D002784:Cholesterol; D000077583:Quinapril