Effects of carnosine and related compounds on the stability and morphology of erythrocytes from alcoholics.
The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These beneficial properties of the dipeptides do not appear to be directly related to their antioxidant or buffering properties.
Prokopieva
V D
VD
Mental Health Research Institute, Medical Academy of Sciences of Russia, Tomsk, Russia.
Bohan
N A
NA
Johnson
P
P
Abe
H
H
Boldyrev
A A
AA
D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000188:drug therapy; D017738:Alkanesulfonic Acids / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002021:Buffers; D002336:Carnosine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006461:Hemolysis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology
D017738:Alkanesulfonic Acids; D000897:Anti-Ulcer Agents; D002021:Buffers; D010879:Piperazines; C033681:N-acetylcarnosine; D002336:Carnosine; C008916:piperazine-N,N'-bis(2-ethanesulfonic acid)