Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind.
Garcinol, a polyisoprenylated benzophenone derivative, was purified from Garcinia indica fruit rind, and its antioxidative activity, chelating activity, free radical scavenging activity, and anti-glycation activity were studied. Garcinol exhibited moderate antioxidative activity in the micellar linoleic acid peroxidation system and also exhibited chelating activity at almost the same level as citrate. It also showed nearly 3 times greater DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging activity than DL-alpha-tocopherol by weight in aqueous ethanol solution. In a phenazine methosulfate/NADH-nitroblue tetrazolium system, garcinol exhibited superoxide anion scavenging activity and suppressed protein glycation in a bovine serum albumin/fructose system. Thus, garcinol might be beneficial as a potent antioxidant and a glycation inhibitor under specified conditions.
Yamaguchi
F
F
Research and Development Division, Kikkoman Corporation, Noda 399, Noda-shi, Chiba Pref. 278-0037, Japan. fyamaguchi@mail.kikkoman.co.jp
Ariga
T
T
Yoshimura
Y
Y
Nakazawa
H
H
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015764:Bepridil / Q000031:analogs & derivatives; D001713:Biphenyl Compounds; D002417:Cattle; D005609:Free Radicals; D005638:Fruit / Q000737:chemistry*; D007202:Indicators and Reagents; D015227:Lipid Peroxidation; D009243:NAD / Q000378:metabolism; D010851:Picrates; D010936:Plant Extracts / Q000378:metabolism*; D013729:Terpenes / Q000378:metabolism*
D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D007202:Indicators and Reagents; D010851:Picrates; D010936:Plant Extracts; D013729:Terpenes; D009243:NAD; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl; C054597:garcinol