title: Dependence of peritoneal clearances on body size in continuous ambulatory peritoneal dialysis: effect of the normalizing size indicator.
abstract: In peritoneal dialysis (PD), small solute clearances are normalized by body water (V) and body surface area (BSA). The purpose of this study was to identify if V or BSA produced stronger associations between body size and normalized clearances. We studied the relationship between four size indicators (V, BSA, height, and weight) and either peritoneal urea clearance normalized to V (Kt/V(ur)) and BSA (C(ur)) or creatinine clearance normalized to V (Kt/V(cr)) and BSA (C(cr)). A total of 613 clearance studies were performed in subjects on continuous ambulatory peritoneal dialysis (CAPD) with four daily exchanges and a 2 L fill volume. As size increased, the normalized peritoneal clearances decreased in a nonlinear fashion (regression: y = b0 + b1x(-1), where x is a size indicator and y is a normalized clearance). Significant (p < 0.001) negative correlations were found between each normalized clearance and each size indicator. However, in each case, the correlation was higher when V, rather than BSA, was used. For example, BSA correlated more closely with K/V(ur)(-0.660) than C(ur)(-0.556), and also with Kt/V(cr)(-0.579) than C(cr)(-0.446). Normalized clearances are smaller in large subjects on CAPD because one mathematic determinant of the clearance, the drain volume (Dv) normalized by V (Dv/V) or BSA (DV/BSA), decreases as size increases. The relationship between Dv/V or Dv/BSA and the size indicators was studied by the same nonlinear regression model. The correlations of the size indicators with Dv/V were also consistently higher than the corresponding correlations with Dv/BSA. In subjects who were on the same PD schedule, the dependence of clearances on size was consistently higher when V, rather than BSA, was the normalizing parameter. Because prescription of the dose of PD is based on body size, there is a practical advantage by using V as the sole normalizing parameter for both urea and creatinine clearance.
authors.affiliation: New Mexico Veterans Affairs Health System, and the Department of Medicine, University of New Mexico School of Medicine, Albuquerque 87108, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Tzamaloukas
authors.forename: G H
authors.initials: GH
authors.lastname: Murata
authors.forename: D
authors.initials: D
authors.lastname: Malhotra
mesh_terms: D001830:Body Surface Area; D006801:Humans; D008657:Metabolic Clearance Rate; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000378:metabolism*; D012044:Regression Analysis; D014508:Urea / Q000493:pharmacokinetics
chemical_list: D014508:Urea