Balloon dilation and endobronchial stent placement for bronchial strictures after lung transplantation.
OBJECTIVE
To evaluate the effect of balloon dilation and endobronchial stent placement for bronchial fibrous stenoses and bronchomalacia after lung transplantation.


METHODS
Bronchial dilation and/or stent placement was performed on 25 lung transplant recipients. Indications included severe dyspnea with postobstructive pneumonia (n = 24) and respiratory failure (n = 1). All patients underwent pulmonary function testing (PFT) before and after bronchial dilation, the results of which were evaluated for changes. A total of 63 procedures were performed between February 1996 and December 1998. Thirty-five lesions were treated (18 were due to bronchomalacia, 17 were due to fibrosis). Areas treated included the left mainstem bronchus (n = 11), bronchus intermedius (n = 10), right mainstem bronchus (n = 7), left upper lobe bronchus (n = 4), right lower lobe bronchus (n = 2), and right middle lobe bronchus (n = 1). Bronchoscopic and/or bronchographic follow-up ranged from 1 to 34 months (mean, 15 months).


RESULTS
Six-month primary patency of stents placed for bronchomalacia was 71% (10 of 14), with three of the four occlusions caused by mechanical failure of Palmaz stents in the mainstem bronchi. Six-month primary patency for treatment of fibrous strictures was 29%. Secondary patency at 1 year was 100% for both bronchomalacia and fibrous strictures. After treatment, there was a significant improvement in mean PFT results (P = .01-.0001). There was one acute complication, obstruction of the left lower lobe bronchus by a Wallstent treated by dilating a hole in the side of the stent.


CONCLUSIONS
Balloon dilation and stent placement are safe and effective for bronchial strictures and bronchomalacia after lung transplantation, resulting in significant improvement in PFT results. However, there is almost universal restenosis in patients treated for fibrous strictures necessitating reintervention for prolonged patency.
Orons
P D
PD
Department of Radiology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA. orons@radsev.arad.upmc.edu
Amesur
N B
NB
Dauber
J H
JH
Zajko
A B
AB
Keenan
R J
RJ
Iacono
A T
AT
D000328:Adult; D001980:Bronchi / Q000473:pathology; D001982:Bronchial Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D002404:Catheterization / Q000009:adverse effects / Q000379:methods; D003251:Constriction, Pathologic; D005260:Female; D005355:Fibrosis; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional; D015607:Stents / Q000009:adverse effects