Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity.
Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbial pathogens and tumors. There is recent evidence for additional functions of these oxygen metabolites in innate and adaptive immunity; these functions include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis, as well as immunodeviating effects. Components of several signal transduction pathways have been identified as intracellular targets for reactive nitrogen and oxygen intermediates.
Bogdan
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C
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D-91054, Germany. christian.bogdan@mikrobio.med.uni-erlangen.de
Röllinghoff
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M
Diefenbach
A
A
D000890:Anti-Infective Agents; D016207:Cytokines / Q000096:biosynthesis*; D007109:Immunity / Q000502:physiology*; D007113:Immunity, Innate; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D010586:Phagocytes; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000890:Anti-Infective Agents; D016207:Cytokines; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II