Prolactin, growth hormone, and IGF-1 in ankles and plasma of adjuvant arthritic rats.
In this study we have investigated the levels of prolactin, growth hormone, and insulin-like growth factor-1 in plasma and in tissue extracts of ankle joints of rats with acute or chronic adjuvant arthritis using enzyme immunoassay (EIA) and radioimmunoassay (RIA). We found a stable content of prolactin in plasma of the different groups but a significantly increased concentration of growth hormone was observed in the plasma of the group with chronic arthritis. Moreover, an increased concentration of insulin-like growth factor-1 was noted in the plasma of the acute group. This evidently had returned to normal levels in the chronic group. In contrast, decreased concentrations of prolactin, growth hormone, and insulin-like growth factor-1 were found in tissue extracts of ankle joints of the group with chronic arthritis. The changes in the levels of these hormones in adjuvant arthritis might suggest that they play a role in the pathogenesis of the disease. Understanding the mechanism(s) of hormonal participation in adjuvant arthritis may open new treatment strategies for rheumatoid arthritis and other inflammatory disorders.
Elhassan
A M
AM
Department of Orthopaedic Surgery, Karolinska Institute, Sweden.
Adem
A
A
Suliman
I A
IA
Mustafa
A
A
Lindgren
J U
JU
D000208:Acute Disease; D000818:Animals; D000843:Ankle Joint / Q000378:metabolism*; D001169:Arthritis, Experimental / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D013006:Growth Hormone / Q000032:analysis*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D010949:Plasma / Q000737:chemistry; D011388:Prolactin / Q000032:analysis*; D051381:Rats; D011917:Rats, Inbred Lew; D012016:Reference Values; D014020:Tissue Extracts / Q000737:chemistry
D014020:Tissue Extracts; D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013006:Growth Hormone