[Factors for postoperative persistent hypertension in patients with aldosterone-producing adenoma].
We determined the factors for postoperative persistent hypertension in the patients with aldosterone-producing adrenal adenoma (APA) in 53 patients with APA who were followed up for average 3.1 years. All had normal serum potassium concentration postoperatively. Blood pressure was normal in 37 patients (69.8%) but 18.7/12.7 kPa or more in 16 patients (30.2%) with persistent hypertension. Also compared were sex, age, history of hypertension, effect of reducing blood pressure to antisterone, preoperative blood pressure, time of persistent hypertension, serum potassium concentration, aldosterone concentration in 24 hour urine, amount of PRA, and the type of operation. The results showed that an APA patient aged 50 years or more appears to have a great chance of persistent hypertension than an APA patient under age of 40 years, and the odds ratio is 3:1. There was a significant difference between the mean age for persistent hypertension and for normal blood pressure, and varioas response of reducing blood pressure to antisterone (P < 0.05). It is suggested that for an older APA patient and the patient without of reducing blood pressure to antisterone, there are other factors for hypertension such as renal veinlet change or renal interstitial lesions except for hyperaldosteronism. We recommend renal biopsy (using kidney puncture) at the operating table for those patients in order to understand pathological change and guide treatment after operation.
Liu
D
D
Department of Urology, Ruijin Hospital, Shanghai Second Medical University.
Zheng
C
C
Chen
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Q
D000236:Adenoma / Q000378:metabolism / Q000601:surgery*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000601:surgery*; D000328:Adult; D000367:Age Factors; D000450:Aldosterone / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006929:Hyperaldosteronism / Q000209:etiology; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D013148:Spironolactone / Q000627:therapeutic use
D013148:Spironolactone; D000450:Aldosterone