Five-lipoxygenase inhibitors reduce Panc-1 survival: synergism of MK886 with gamma linolenic acid.
Harris
J E
JE
Department of Medicine, Rush Medical College, Chicago, Il. 60612, USA.
Alrefai
W A
WA
Meng
J
J
Anderson
K M
KM
D058927:5-Lipoxygenase-Activating Proteins; D000577:Amides / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects; D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D002470:Cell Survival / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D007211:Indoles / Q000008:administration & dosage*; D016859:Lipoxygenase Inhibitors / Q000008:administration & dosage*; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D011725:Pyridines / Q000008:administration & dosage; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured; D020298:U937 Cells; D017965:gamma-Linolenic Acid / Q000008:administration & dosage*; D002722:Chlorobenzenes
D058927:5-Lipoxygenase-Activating Proteins; D000577:Amides; D001094:Arachidonate 5-Lipoxygenase; D002352:Carrier Proteins; D007211:Indoles; D016859:Lipoxygenase Inhibitors; D008565:Membrane Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011725:Pyridines; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D017965:gamma-Linolenic Acid; C548592:ALOX5AP protein, human; C060893:MK-886; D002722:Chlorobenzenes; C081292:SC 41661A