Prognostic factors in non-Hodgkin lymphomas.
BACKGROUND
In Hodgkin's disease, each clinical or pathologic stage can be related to the extent of the area involved and predicts the next anatomical region at risk for tumor dissemination.


OBJECTIVE
To determine the best prognostic factors that could predict survival in non-Hodgkin lymphoma cases.


METHODS
A retrospective study.


METHODS
Department of Hematology and Transfusion Medicine, Universidade Federal de São Paulo - Escola Paulista de Medicina.


METHODS
142 patients with non-Hodgkin lymphoma diagnosed between February 1988 and March 1993.


METHODS
Histological subset, Sex, Age, Race, B symptoms, Performance status, Stage, Extranodal disease, Bulk disease, Mediastinal disease, CNS involvement, BM infiltration, Level of DHL, Immunophenotype.


RESULTS
In the first study (113 patients), the following variables had a worse influence on survival: yellow race (P<0.1); ECOG II, III e IV (P<0.1) and extranodal disease (P<0.1) for high grade lymphomas; constitutional symptoms (P<0.1), ECOG II, III e IV (P<0.1) and involvement of CNS (P<0.1) for intermediate grade and the subtype lymphoplasmocytoid (P=0.0186) for low grade lymphomas. In the second survey (93 patients), when treatment was included, the variables related to NHL survival were: CNS involvement (P<0.1) for high grade lymphomas, constitutional symptoms (P<0.1), ECOG II, III, IV (P=0.0185) and also CNS involvement (P<0.1) for the intermediate group. There were no variables related to the survival for low-grade lymphomas.


CONCLUSIONS
The intermediate grade lymphomas were more compatible with data found in the literature, probably because of the larger number of patients. In this specific case, the treatment did not have an influence on the survival.
Cecyn
K Z
KZ
Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Oliveira
J S
JS
Alves
A C
AC
Silva
M R
MR
Kerbauy
J
J
D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors