[Neurophysiological correlates of delayed visual differentiation in monkeys: effect of location of the NMDA-receptor intracortical blockade].
A multi-factor variance analysis revealed that the 2-amino-5-phosphonovalerian acid (APV) effect was manifested in monkeys by a decrease in the number of correct responses entailing a two-fold shortening of the short-term information storage, as well as by an augmentation of the motor responses' time. The correct responses' probability depended on the APV diffusion localisation in the cortex whereas the motor responses' time did not depend on it. The APV effect was accompanied by a desynchronisation of the unit activity in fields 46 and 17. Neurophysiological correlates of cognitive functions, are discussed.
Dudkin
K N
KN
I. P. Paylov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
Kruchinin
V K
VK
Chueva
I V
IV
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology*; D004594:Electrophysiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D014793:Visual Cortex / Q000187:drug effects / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D015763:2-Amino-5-phosphonovalerate