Using molecular epidemiology in assessing exposure for risk assessment.
Quantitative estimation of health risks depends on exposure characterization, the nature of the dose response relationships, and the toxicity of the agents involved. The greatest uncertainties in risk assessment almost always arise from sparse or inadequate exposure data, inadequate understanding of exposure mechanisms, and insufficient understanding of the exposure-dose-response pathway. Additional sources of uncertainty arise when mixed or multiple exposures are implicated in the disease pathway, and as a result of variability in both exposures and responses within and between individuals. Here we consider the role of exposure assessment in the risk assessment process, the use of biological markers or molecular epidemiology to contribute to improvements in exposure assessment for risk assessment, and uncertainties associated with the use of biological markers.
Schulte
P A
PA
National Institute for Occupational Safety and Health (NIOSH), Education and Information Division, Robert A. Taft Laboratories, Cincinnati, Ohio 45226, USA. pas4@cdc/gov
Waters
M
M
D015415:Biomarkers / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000032:analysis*; D006801:Humans; D017720:Molecular Epidemiology; D015203:Reproducibility of Results; D012107:Research Design; D018570:Risk Assessment; D015262:Xenobiotics / Q000009:adverse effects*
D015415:Biomarkers; D015262:Xenobiotics