Focal nodular hyperplasia: natural course observed with CT and MRI.
OBJECTIVE
The purpose of this work was to assess the natural course of biopsy-proven focal nodular hyperplasia (FNH).


METHODS
Eighteen biopsy-proven FNHs in 14 patients (12 women and 2 men) who were followed for at least 6 months with CT and/or MRI were included in the study. The volume of the lesions was calculated twice by two observers using the summation of areas method. Intra- and interobserver variability was assessed by intraclass correlation coefficients. Longitudinal data analysis was performed with generalized estimating equations.


RESULTS
The volume of FNH was stable in 6 cases, decreased in 10 cases, and increased in 2 cases. Intra- and interobserver variability in size measurements was 5-10%. Intraclass correlation coefficients were >0.992. Longitudinal data analysis showed that there was a general trend of lesion regression.


CONCLUSIONS
Long-term follow-up and objective measurements performed in patients with biopsy-proven lesions show that the natural course of FNH is variable. In particular, lesion regression is not rare.
Leconte
I
I
Department of Radiology, Université Catholique de Louvain, St. Luc University Hospital, Brussels, Belgium.
Van Beers
B E
BE
Lacrosse
M
M
Sempoux
C
C
Jamart
J
J
Materne
R
R
Baudrez
V
V
Horsmans
Y
Y
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed