[The effect of sodium alpha-glutarate on enzymatic transamination activity and on succinate dehydrogenase in rats with different resistances to hypoxia].
It have been found that intraperitoneal alpha-ketoglutarate injection (20 mg/100 g body weight) results in increase in the influence of cholinergic regulation mechanisms. It also results in increase of aminotransferase activity on background of the decrease of succinate dehydrogenase activity in liver and pancreas tissues and in small intestines mucous. Activity of transamination enzymes and succinate dehydrogenase activity is much higher in the case of rats with high hypoxia resistance, alpha-ketoglutarate injection results in increase of transamination enzymes activity in the organisms of rats with low resistance to hypoxia up to the control level of rats with high resistance, and simultaneously increases rats resistance to hypoxia. Effect of alpha-ketoglutarate injection on the energetical exchange in the tissues with different parasympathetic dependence taking from the animals with different hypoxia resistance is suppressed by blockade of M- and H-cholinoceptors.
Kurhaliuk
N M
NM
I. Franko University, Ministry of Education, Lviv.
Shostakovs'ka
I V
IV
D000586:Amination / Q000187:drug effects; D000818:Animals; D004064:Digestive System / Q000187:drug effects / Q000201:enzymology; D004734:Energy Metabolism / Q000187:drug effects; D000860:Hypoxia / Q000201:enzymology*; D007113:Immunity, Innate / Q000187:drug effects; D007656:Ketoglutaric Acids / Q000494:pharmacology*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D000637:Transaminases / Q000187:drug effects* / Q000378:metabolism
D007656:Ketoglutaric Acids; D013385:Succinate Dehydrogenase; D000637:Transaminases