Busulfan clearance in renal failure and hemodialysis.
The impact of hemodialysis on the clearance of busulfan was determined in a patient with chronic renal failure undergoing autologous peripheral stem cell transplantation for non-Hodgkin's lymphoma. The extraction ratio for busulfan across the dialyzer was 0.530 +/- 0.026 at a blood flow of 400 ml/min, which corresponds to a hemodialysis clearance of 2.23 +/- 0.11 ml/min/kg body weight. Apparent oral clearance of busulfan without hemodialysis was 3.38 +/- 0.56 ml/min/kg. Thus, a 4 h hemodialysis session enhanced the apparent oral clearance of busulfan by 65%. We conclude that hemodialysis effectively removes busulfan from circulating blood, but a standard hemodialysis period (ie, 4 h) does not significantly alter busulfan exposure. Bone Marrow Transplantation(2000) 25, 201-203.
Ullery
L L
LL
St Joseph Medical Center, Tacoma, WA 98109-1024, USA.
Gibbs
J P
JP
Ames
G W
GW
Senecal
F M
FM
Slattery
J T
JT
D000284:Administration, Oral; D001682:Biological Availability; D001804:Blood Transfusion, Autologous; D002066:Busulfan / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors; D019172:Transplantation Conditioning / Q000379:methods
D002066:Busulfan