title: Preclinical mouse models for cancer chemoprevention studies.
abstract: To aid in identifying the ability of chemopreventive agents to inhibit tumor development, new preclinical in vivo rodent models have recently been developed. Some of the models contain targeted mutations capable of increasing the incidence and progression of neoplastic lesions, whereas in other models dietary nutrients induce preneoplastic lesions in normal mice. These new preclinical models are assisting the analysis of genetic and environmental factors leading to neoplasia, and clinical studies to evaluate the chemopreventive efficacy of specific nutrients and pharmacological agents.
authors.affiliation: Strang Cancer Research Laboratory, Rockefeller University, New York, New York 10021, USA. lipkin@rockvax.rockefeller.edu
authors.forename: M
authors.initials: M
authors.lastname: Lipkin
authors.forename: K
authors.initials: K
authors.lastname: Yang
authors.forename: W
authors.initials: W
authors.lastname: Edelmann
authors.forename: L
authors.initials: L
authors.lastname: Xue
authors.forename: K
authors.initials: K
authors.lastname: Fan
authors.forename: M
authors.initials: M
authors.lastname: Risio
authors.forename: H
authors.initials: H
authors.lastname: Newmark
authors.forename: R
authors.initials: R
authors.lastname: Kucherlapati
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000517:prevention & control*