Preparation and biodistribution of rhenium-188 labeled albumin microspheres B 20: a promising new agent for radiotherapy.
Intra-arterial infusion of labeled particles is an effective method for endoradiotherapy of tumors. In this study, we radiolabeled biodegradable HSA microspheres (mean diameter = 25 microm) with the short-lived beta-emitter 188Re available from the aluminia-based 188W/188Re generator system. After 1 h 35-40% of the relative large amount of Sn(II) chloride required for effective reduction of Re(VII) for efficient attachment to the particles is precipitated as an amorphous coat of tin hydroxid colloid on the particle surface. The final 188Re bound to the particles was found to be stable in vitro. The radiolabelling yield was > 90%. The biological half-life was > 250 h and demonstrated sufficient in vivo stability after i.v. injection in Wistar rats. Because of the attractive properties of 188Re and the uniform particle size and stability, in vivo, this new agent is an attractive candidate for endoradiotherapy of tumors after selective catheterization.
Wunderlich
G
G
University Hospital, Department of Nuclear Medicine, Dresden, Germany.
Pinkert
J
J
Andreeff
M
M
Stintz
M
M
Knapp
F F
FF
Kropp
J
J
Franke
W G
WG
D000418:Albumins; D000818:Animals; D006207:Half-Life; D006801:Humans; D066298:In Vitro Techniques; D007261:Infusions, Intra-Arterial; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011878:Radiotherapy / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution
D000418:Albumins; D011868:Radioisotopes; D012211:Rhenium