Chromogranin A expression in hepatocellular carcinoma in a patient with germline MEN1 gene mutation.
Hepatocellular carcinoma (HCC) was found in a patient with multiple endocrine neoplasia type 1 (MEN 1). The intriguing finding was that the HCC in the patient was positively stained for chromogranin A (CgA), a cellular marker for endocrine and neuroendocrine tumors. The patient had a pancreas endocrine tumor and type C hepatitis, that made pathological diagnosis of the origin of the tumor complicated.
Nakajima
K
K
Department of Aging Medicine and Geriatrics, Shinshu University School of Medicine, Matsumoto.
Sakurai
A
A
Katai
M
M
Yajima
H
H
Mori
J
J
Katakura
M
M
Tsuchiya
S
S
Hashizume
K
K
D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000150:complications*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D017809:Fatal Outcome; D018095:Germ-Line Mutation; D005935:Glucagonoma / Q000737:chemistry; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008099:Liver / Q000737:chemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000150:complications*; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000737:chemistry; D010179:Pancreas / Q000737:chemistry; D010190:Pancreatic Neoplasms / Q000737:chemistry
C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins