A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Lovell
P J
PJ
SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, U.K. Peter_J_Lovell@sbphrd.com
Bromidge
S M
SM
Dabbs
S
S
Duckworth
D M
DM
Forbes
I T
IT
Jennings
A J
AJ
King
F D
FD
Middlemiss
D N
DN
Rahman
S K
SK
Saunders
D V
DV
Collin
L L
LL
Hagan
J J
JJ
Riley
G J
GJ
Thomas
D R
DR
D002460:Cell Line; D006801:Humans; D008958:Models, Molecular; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
D010636:Phenols; D011985:Receptors, Serotonin; D011994:Recombinant Proteins; C404922:SB 269970; D012702:Serotonin Antagonists; D013449:Sulfonamides; C104425:serotonin 7 receptor