title: Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion.
abstract: Lung Chen Tea, a Chinese green tea, has been found to lower serum and liver cholesterol. In this study, its dose response and mechanisms of action on cholesterol lowering in diet-induced hypercholesterolemic Sprague-Dawley rats were investigated. The activities of three major lipid metabolizing enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-Co A) reductase, cholesterol 7alpha-hydroxylase and fatty acid synthase (FAS), as well as fecal excretion of bile acids and cholesterol were examined. Lung Chen Tea administration for eight weeks significantly lowered the serum cholesterol in the 2% and 4% groups. The activities of the three enzymes were not affected by Lung Chen Tea, but the fecal bile acids and cholesterol excretions were significantly increased. These results demonstrated that Lung Chen Tea lowered plasma cholesterol by increasing fecal bile acids and cholesterol excretion. Further investigation is required to evaluate the exact mechanisms of action of Lung Chen Tea.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong.
authors.forename: T T
authors.initials: TT
authors.lastname: Yang
authors.forename: M W
authors.initials: MW
authors.lastname: Koo
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis*; D001835:Body Weight; D002392:Catechin / Q000032:analysis; D002784:Cholesterol / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004326:Drinking; D004435:Eating; D064429:Fatty Acid Synthases / Q000378:metabolism; D005243:Feces / Q000737:chemistry*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D009929:Organ Size; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013662:Tea / Q000737:chemistry / Q000627:therapeutic use*; D014280:Triglycerides / Q000032:analysis / Q000097:blood
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D013662:Tea; D014280:Triglycerides; D002392:Catechin; D002784:Cholesterol; D006903:Hydroxymethylglutaryl CoA Reductases; D025782:Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; D002790:Cholesterol 7-alpha-Hydroxylase; D064429:Fatty Acid Synthases