title: [Inflammatory and/or locally advanced breast cancers. Difficulty evaluating the response to initial chemotherapy].
abstract: At the Tenon Hospital (Paris), 48 inflammatory or locally advanced breast cancers were treated by neoadjuvant chemotherapy (three different protocols), followed by surgery (mastectomy or tumorectomy and axillary dissection). The histological data of the specimens are analyzed with regard to the clinical and radiologic evolution. Twenty complete clinical responses (41%), 22 partial clinical responses (45%), and no response in six cases (14%) were observed. Histology demonstrated residual tumors in 42 cases (87.5%), even in the case of complete clinical response (14 cases), without notable change of the grade (SBR). Lymph node clearance demonstrated positive nodes in 38 cases (79%). Despite its great agreement with clinical examination, mammography does not predict the existence of histological residual tumors after initial chemotherapy. Chemotherapy allowed local treatment, but can rarely sterilize the tumor completely.
authors.affiliation: Département de diagnostic et traitement des cancers du sein, Hôpital Tenon, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Ghazli
authors.forename: S
authors.initials: S
authors.lastname: Sananes
authors.forename: J
authors.initials: J
authors.lastname: Chopier
authors.forename: E
authors.initials: E
authors.lastname: Touboul
authors.forename: J P
authors.initials: JP
authors.lastname: Lotz
authors.forename: M
authors.initials: M
authors.lastname: Antoine
authors.forename: J M
authors.initials: JM
authors.lastname: Antoine
authors.forename: S
authors.initials: S
authors.lastname: Uzan
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001365:Axilla; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008327:Mammography; D008408:Mastectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012074:Remission Induction; D016896:Treatment Outcome