[The effects of Tripterygium wilfordii polyglycosidium on neuromuscular junctions of adult toad].
The effects of tripterygium wilfordii polyglycosidium (TWP) on the transmission at the neuromuscular junctions (NMJ) of sciatic nerve-sartorius muscle preparations of 20 adult toads (Bufo bufo gargarizans) in vitro were studied by means of intracellular microelectrode recording of endplate potentials (EPP). The results revealed that TWP could cause changes of EPP amplitude so as to influence the transmission at NMJ, and the effects apparently depended on the concentration of the drug. A proper concentration of TWP could produce a significant increase in EPP amplitude and therefore facilitate the transmission at the NMJ.
Lü
G
G
Department of Physiology, School of Basic Medical Sciences, Chengdu.
Zhou
L
L
Xu
J
J
D000818:Animals; D002023:Bufo bufo; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008839:Microelectrodes; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D012584:Sciatic Nerve / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D006027:Glycosides