title: Effects of hormone replacement therapy on lipid peroxides and oxidation system in postmenopausal women.
abstract: A short-term evaluation of 6 months of estrogen therapy on oxidant status in 38 postmenopausal women was conducted. The levels of serum lipid peroxidation products, glutathione (GSH) status, and glutathione-related enzymes were evaluated before and after 6 months of hormone replacement therapy. After 6 months of estrogen treatment there was a significantly increased concentration of thiobarbituric acid-reactive substances (TBARS), which are an end product of lipid peroxidation. This was accompanied by a significant increase in the activity of glutathione peroxidase (GSH-Px). However, the activities of glutathione reductase (GSSG-R) and superoxide dismutase (SOD) were significantly decreased and total protein thiols were reduced. Data suggest that hormone replacement therapy in postmenopausal women is associated with oxidant mechanisms.
authors.affiliation: Biochemistry Department, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Akçay
authors.forename: Y
authors.initials: Y
authors.lastname: Dinçer
authors.forename: R
authors.initials: R
authors.lastname: Kayali
authors.forename: U
authors.initials: U
authors.lastname: Colgar
authors.forename: E
authors.initials: E
authors.lastname: Oral
authors.forename: U
authors.initials: U
authors.lastname: Cakatay
mesh_terms: D015914:Estrogen Replacement Therapy; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction; D017698:Postmenopause / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione