Toxic epidermal necrolysis associated with acetaminophen ingestion.
OBJECTIVE
To report a case of toxic epidermal necrolysis (TEN) associated with acetaminophen ingestion.


CONCLUSIONS
A seven-year-old girl developed TEN after acetaminophen ingestion. The diagnosis was based on clinical evaluation and skin biopsy. A later acetaminophen challenge, undertaken by an allergist who questioned the diagnosis, resulted in a similar skin reaction.


CONCLUSIONS
TEN is a severe disease with a high mortality rate. TEN may be either idiopathic or associated with several clinical conditions, such as viral infections, autoimmune disorders, malignancy, and drug hypersensitivity. Because of the rarity of its association with acetaminophen, the diagnosis in our patient was questioned by an allergist who performed an oral acetaminophen rechallenge test despite the potential risk. This caused a severe skin reaction that required rehospitalization.


CONCLUSIONS
TEN can be caused by over-the-counter medications such as acetaminophen. Rechallenge with the causative drug carries a risk of severe complications and should be avoided.
Halevi
A
A
Department of Pediatrics, Schneider Children's Medical Center of Israel, Beilinson Campus, Petah Tiqva.
Ben-Amitai
D
D
Garty
B Z
BZ
D000082:Acetaminophen / Q000008:administration & dosage / Q000009:adverse effects*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D005260:Female; D005334:Fever / Q000139:chemically induced; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000473:pathology*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen