Decreased hemispheric water mobility in hemiplegic migraine related to mutation of CACNA1A gene.
We report a reversible reduction of water diffusion in the brain during a prolonged attack of hemiplegic migraine. The patient had a sporadic mutation of the CACNA1A gene. The diffusion changes were observed in the contralateral hemisphere 3 and 5 weeks after the onset of hemiplegia. These results suggest the occurrence of hemispheric cytotoxic edema during severe attacks of hemiplegic aura. The mechanisms underlying such ultrastructural modifications are unknown but an abnormal release of excitatory amino acids can be hypothesized.
Chabriat
H
H
Service de Neurologie Hôpital Lariboisière, Paris France.
Vahedi
K
K
Clark
C A
CA
Poupon
C
C
Ducros
A
A
Denier
C
C
Le Bihan
D
D
Bousser
M G
MG
D000328:Adult; D015220:Calcium Channels / Q000235:genetics*; D002540:Cerebral Cortex / Q000378:metabolism* / Q000473:pathology; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008881:Migraine Disorders / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D009154:Mutation; D014867:Water / Q000378:metabolism*; D020864:Calcium Channels, N-Type
D015220:Calcium Channels; D014867:Water; C105656:CACNA1A protein, human; D020864:Calcium Channels, N-Type