[Participation of transcriptional factors in the regulation of lymphocyte differentiation].
The cytomorphological changes as well as the expression of certain markers in the different stages of lymphocyte differentiation are well known. Studies carried out on expression patterns of specific genes in lymphoid cells and their regulatory mechanism have led to the identification of the fundamental mechanism of cell development and activation. A great deal of knowledge has accumulated concerning enhancers and promoters, the regulatory elements of those genes and the transcriptional factors to which they bind. The present paper analyzes these components and the participation of some of them such as PU.1, Ikaros, Aiolos, GATA-3, Egf-1, E2A, EBF-1, PAX-5 (BSAP), TFE-3, Oct-1, Oct-2, and Nf-kappa B in the regulation of the differentiation stages of cells belonging to the B and T lymphoid lineages.
Margni
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RA
IDEHU-Instituto de Estudios de la Inmunidad Humoral (CONICET-UBA), Departamento de Microbiología, Inmunología y Biotecnología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina. ramargni@ffyb.uba.ar
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology; D014157:Transcription Factors
D014157:Transcription Factors