title: Evaluation of the BT-1 serum assay for breast cancer.
abstract: The BT-1 assay which identifies a novel breast tumor associated serum analyte was performed for 143 patients previously diagnosed with breast cancer. Mucin tumor markers CA15-3/CA27-29 values were available for 50 patients and there was very minor overlap between patients positive by both tests. Patients' follow-up clinical status at sample draw was compared to BT-1 assay results. 27% of patients originally diagnosed as Stage II and 20% patients originally diagnosed as Stage III who were evaluated 'no disease' had positive BT-1 values. 8% patients diagnosed as Stage II had negative BT-1 results in samples drawn within 90 days of chemotherapy initiation, whereas 23% of patients diagnosed as Stage III cancer were BT-1 test positive within 90 days of chemotherapy initiation. 50% of patients tested before initial breast cancer surgery had positive BT-1 values, suggesting that the BT-1 assay may be useful in identification women with more advanced disease at diagnosis.
authors.affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Whitehurst
authors.forename: P H
authors.initials: PH
authors.lastname: Aldenderfer
authors.forename: M M
authors.initials: MM
authors.lastname: Sooy
authors.forename: A J
authors.initials: AJ
authors.lastname: Strelkauskas
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D004797:Enzyme-Linked Immunosorbent Assay; D005069:Evaluation Studies as Topic; D005260:Female; D006304:Health Status; D006801:Humans; D018396:Mucin-1 / Q000097:blood; D009367:Neoplasm Staging; D012189:Retrospective Studies
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C090797:CA 27-29 antigen; D018396:Mucin-1