Solution-phase combinatorial synthesis and evaluation of piperazine-2,5-dione derivatives.
An efficient one-pot synthesis of a 61-membered combinatorial chemistry library of piperazine-2,5-diones was accomplished. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.
Loughlin
W A
WA
School of Science, Griffith University, Brisbane, Australia.
Marshall
R L
RL
Carreiro
A
A
Elson
K E
KE
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000633:toxicity; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000633:toxicity; D020650:Combinatorial Chemistry Techniques; D033364:Decapoda / Q000187:drug effects; D015394:Molecular Structure; D010879:Piperazines / Q000138:chemical synthesis* / Q000633:toxicity
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D010879:Piperazines