title: An outbreak of Streptococcus pneumoniae serotype 1 in a closed community in southern Israel.
abstract: An outbreak of Streptococcus pneumoniae serotype 1 occurred in a closed community that was characterized by poverty and crowding. Vaccine was administered to individuals aged >2 years; no new cases occurred among vaccine recipients. Six weeks after vaccination, carriage of serotype 1, but not of other serotypes, decreased 8.8-fold. This suggests that the reduction in serotype 1 carriage reflects the natural course of the outbreak rather than a vaccine effect. Polysaccharide vaccine may be helpful in terminating pneumococcal outbreaks but may not affect pneumococcal carriage.
authors.affiliation: Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva 84101, Israel. rdagan@bgumail.bgu.ac.il
authors.forename: R
authors.initials: R
authors.lastname: Dagan
authors.forename: S
authors.initials: S
authors.lastname: Gradstein
authors.forename: I
authors.initials: I
authors.lastname: Belmaker
authors.forename: N
authors.initials: N
authors.lastname: Porat
authors.forename: Y
authors.initials: Y
authors.lastname: Siton
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: J
authors.initials: J
authors.lastname: Janco
authors.forename: P
authors.initials: P
authors.lastname: Yagupsky
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002353:Carrier State / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000517:prevention & control*; D005260:Female; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D011336:Probability; D012307:Risk Factors; D012424:Rural Population; D012703:Serotyping; D017678:Sex Distribution; D013296:Streptococcus pneumoniae / Q000145:classification
chemical_list: D001428:Bacterial Vaccines