Hypothetical double-helical poly(A) formation in a cell and its possible biological significance.
Arguments are presented in favor of capability of poly(A)-tracts of cellular RNA to form double helices in vivo. It is suggested that formation of the double helix in the mRNA poly(A) tall provides the basis for such processes as polyadenylation termination, PAB I synthesis autoregulation, and stabilization of ARE-containing mRNA by ELAV-like proteins.
Zarudnaya
M I
MI
Molecular Biophysics Department, Ukrainian National Academy of Sciences, Kyiv, Ukraine. svitlana@imbig.kiev.ua
Hovorun
D M
DM
D009690:Nucleic Acid Conformation; D011061:Poly A / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism*; D012330:RNA, Double-Stranded / Q000096:biosynthesis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism
D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D011061:Poly A