Productive replication of human adenoviruses in mouse epidermal cells.
In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.
Ganly
I
I
CRC Department of Medical Oncology, CRC Beatson Laboratories, Glasgow G61 1BD, Scotland.
Mautner
V
V
Balmain
A
A
D016475:3T3 Cells; D017500:Adenovirus E1A Proteins / Q000096:biosynthesis; D000260:Adenoviruses, Human / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral; D004817:Epidermis / Q000821:virology; D006801:Humans; D051379:Mice; D014407:Tumor Cells, Cultured; D016596:Vinculin / Q000096:biosynthesis; D014779:Virus Replication
D017500:Adenovirus E1A Proteins; D016596:Vinculin