title: [Mechanisms for the therapeutic effect of herpes polyvaccines in chronic ophthalmic herpes and genital herpes].
abstract: Commercial inactivated culture polyvaccine against herpes simplex viruses (types 1 and 2) developed at D. I. Ivanovsky Institute of Virology promoted cessation of viremia. During the first vaccination viremia coincided with appearance of a focal allergic test on the retina, which is proposed for the diagnosis of herpetic involvement of the posterior compartment of the eye. T-cellular immunity normalized after a course of vaccination. Experimental immunization of rats and vaccination of patients with chronic ophthalmic and genital herpes demonstrated the therapeutic activity of inactivated herpetic polyvaccine in suppositoria.
authors.forename: I F
authors.initials: IF
authors.lastname: Barinskiĭ
authors.forename: L G
authors.initials: LG
authors.lastname: Karpovich
authors.forename: E I
authors.initials: EI
authors.lastname: Gubanova
authors.forename: I V
authors.initials: IV
authors.lastname: Belkina
authors.forename: T B
authors.initials: TB
authors.lastname: Semenova
authors.forename: A A
authors.initials: AA
authors.lastname: Lazarenko
authors.forename: A A
authors.initials: AA
authors.lastname: Davydova
authors.forename: I I
authors.initials: II
authors.lastname: Samoĭlenko
authors.forename: A A
authors.initials: AA
authors.lastname: Kasparov
mesh_terms: D000818:Animals; D006558:Herpes Genitalis / Q000097:blood / Q000276:immunology / Q000628:therapy*; D006801:Humans; D016849:Keratitis, Herpetic / Q000097:blood / Q000276:immunology / Q000628:therapy*; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D014765:Viral Vaccines / Q000627:therapeutic use*; D014766:Viremia
chemical_list: D014765:Viral Vaccines