Small-molecule inhibitors of the cell cycle.
The cell cycle remains an attractive target for the development of small-molecule inhibitors for use as both novel chemotherapeutics and research probes. Given the importance of cytoskeletal dynamics and cyclin-dependent kinases for cell-cycle progression, much interest has focused on the identification of anti-mitotic agents and kinase inhibitors. However recent advances in cell-based screening technologies and an increased interest in inhibitors with greater specificity are beginning to influence the search for novel cell-cycle inhibitors.
Crews
C M
CM
Departments of Molecular, Cellular, and Developmental Biology and Pharmacology, Yale University, New Haven, CT 06520-8103, USA. craig. crews@yale.edu.
Mohan
R
R
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008870:Microtubules / Q000187:drug effects
D004791:Enzyme Inhibitors; D018844:Cyclin-Dependent Kinases