title: Clinical, histological and immunopathological features of 58 patients with subacute cutaneous lupus erythematosus. A review by the Italian group of immunodermatology.
abstract: BACKGROUND
  Subacute cutaneous lupus erythematosus (SCLE) is a distinct subset of cutaneous lupus erythematosus clinically characterized by psoriasiform and/or annular lesions and by a mild or absent systemic involvement.
  
  
  OBJECTIVE
  The Italian Group of Immunodermatology of the Italian Society of Dermatology and Venereology reviewed the cases of SCLE seen in 10 years (1987-1996).
  
  
  METHODS
  Forty-six women and 12 men have been retrospectively studied, 42% had annular lesions, 39% psoriasiform ones and 16% both.
  
  
  RESULTS
  Lesions were mainly localized on the neck and face and relapsed in spring and autumn. Seventeen patients had 4 or more American College of Rheumatology criteria and could be classified as having systemic lupus erythematosus. The most frequent histopathological alterations were epidermal atrophy, hydropic degeneration of the basal layer and perivascular lymphocytic infiltrate. Deposits of immunoglobulins and C3 at the dermo-epidermal junction on the clinically involved skin were present in 86% of the patients. Dust-like particles in the epidermis were only found in 3% of cases. Anti-Ro/SSA antibodies were found in 71% of the cases and anti-dsDNA only in 5% of cases.
  
  
  CONCLUSIONS
  SCLE is a particular subset of cutaneous lupus erythematosus with peculiar clinical and immunopathological features.
authors.affiliation: Sezione di Dermatologia, Università di Genova, DISEM, Genova, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Parodi
authors.forename: M
authors.initials: M
authors.lastname: Caproni
authors.forename: C
authors.initials: C
authors.lastname: Cardinali
authors.forename: E
authors.initials: E
authors.lastname: Bernacchi
authors.forename: A
authors.initials: A
authors.lastname: Fuligni
authors.forename: G
authors.initials: G
authors.lastname: De Panfilis
authors.forename: C
authors.initials: C
authors.lastname: Zane
authors.forename: M
authors.initials: M
authors.lastname: Papini
authors.forename: F C
authors.initials: FC
authors.lastname: Veller
authors.forename: M
authors.initials: M
authors.lastname: Vaccaro
authors.forename: P
authors.initials: P
authors.lastname: Fabbri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000974:Antibodies, Antinuclear / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D015941:Complement Hemolytic Activity Assay; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007150:Immunohistochemistry; D007223:Infant; D007558:Italy; D008178:Lupus Erythematosus, Cutaneous / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012867:Skin / Q000737:chemistry / Q000276:immunology / Q000473:pathology*
chemical_list: D000974:Antibodies, Antinuclear; D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins