title: Mood state and brain electric activity in ecstasy users.
abstract: Resting EEG during open and closed eyes and subsequent mood ratings were obtained from 15 Ecstasy users and 14 Ecstasy-naive controls. Absolute spectral power on the scalp, and the three-dimensional, intracerebral distribution of neuroelectric activity using low resolution brain electromagnetic tomography (LORETA) were computed. LORETA revealed global increases of theta, alpha 1 and beta 2/3 power during eyes open in Ecstasy users, and spectral analyses revealed a right-posterior increase of alpha 2 power (confirmed by LORETA) and increased beta band activity during open eyes. Ecstasy users had higher levels of state depressiveness, emotional excitability and a trend-level increase in state anxiety. The observed differences may be related to regular exposure to Ecstasy or other illicit drugs, or may be pre-existing.
authors.affiliation: KEY Institute for Brain-Mind Research, University Hospital of Psychiatry, Zurich, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Gamma
authors.forename: E
authors.initials: E
authors.lastname: Frei
authors.forename: D
authors.initials: D
authors.lastname: Lehmann
authors.forename: R D
authors.initials: RD
authors.lastname: Pascual-Marqui
authors.forename: D
authors.initials: D
authors.lastname: Hell
authors.forename: F X
authors.initials: FX
authors.lastname: Vollenweider
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D001007:Anxiety / Q000139:chemically induced / Q000523:psychology; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D006213:Hallucinogens / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects / Q000494:pharmacology*; D014054:Tomography
chemical_list: D006213:Hallucinogens; D018817:N-Methyl-3,4-methylenedioxyamphetamine