title: Surgical treatment for recurrent gastro-oesophageal reflux disease after failed antireflux surgery.
abstract: BACKGROUND
  Recurrent or persistent symptoms occur in 10-15 per cent of patients after antireflux surgery. Failure of surgery is not uniform in its presentation. The cause of failure is not easily detected and even harder to treat. Different approaches have been proposed and few reports are available on the objective and subjective outcome of reoperation.
  
  
  METHODS
  This study focuses on 30 patients (16 men and 14 women; age range 20-69 years) with recurrent symptomatic gastro-oesophageal reflux disease (GORD) resistant to medical treatment. In all patients reoperation was by the Belsey Mark IV antireflux operation. A clinical history, endoscopy and oesophageal manometry were obtained in all patients, and 24-h pH monitoring was performed in 27 of 30 before and in most patients after the Belsey procedure.
  
  
  RESULTS
  Symptomatic improvement was reported in 24 of 30 patients. Oesophagitis (present before operation in 19 patients) was cured or remained absent in 24 of 30 patients, stabilized in one, improved in four and deteriorated in one. Relief of symptoms combined with absence of oesophagitis was obtained in 21 of 30 patients, with concomitant normalization of the 24-h pH profile in 11 of 22 patients. The median basal lower oesophageal sphincter (LOS) pressure increased significantly from 6. 9 to 9.0 mmHg (P < 0.01). Redo surgery had no effect on oesophageal body motility.
  
  
  CONCLUSIONS
  Reoperation performed for documented recurrent GORD had a good and lasting effect on symptoms, on oesophagitis (both in 24 of 30 patients) and on the combination of both (21 of 30). In these patients reoperation increased basal LOS pressure and decreased reflux time. Overall, the results approximate to those of primary operation.
authors.affiliation: Department of Surgery, University Medical Centre Leiden, Leiden, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Bais
authors.forename: T L
authors.initials: TL
authors.lastname: Horbach
authors.forename: A A
authors.initials: AA
authors.lastname: Masclee
authors.forename: A J
authors.initials: AJ
authors.lastname: Smout
authors.forename: J L
authors.initials: JL
authors.lastname: Terpstra
authors.forename: H G
authors.initials: HG
authors.lastname: Gooszen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D002648:Child; D002675:Child, Preschool; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D012008:Recurrence; D012086:Reoperation; D017211:Treatment Failure