title: Sequential Nucleophilic Substitution: A Powerful Strategy for the Solid-Phase Production of Diverse Compound Libraries.
abstract: Polyfunctionalized, unprotected reagents (e.g. amines and thiols) can be used in the production of highly diverse compound libraries by performing sequential nucleophilic substitutions on support-bound polyelectrophiles (see scheme). The procedure reported here enables the efficient preparation of new beta-alanine derivatives which are suitable for lead discovery. E*=polyelectrophile, *=solid support.
authors.affiliation: Novo Nordisk A/S Novo Nordisk Park, 2760 Måløv (Denmark).
authors.initials: F
authors.lastname: Zaragoza
authors.initials: H
authors.lastname: Stephensen