Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes.
Analysis of the mechanisms underlying CNS immune surveillance and immunopathology have provided new insights into the intracerebral regulation of immune responses. Here, Francesca Aloisi, Francesco Ria and Luciano Adorini review the role of CNS antigen presenting cells and focus on the control of Th1 and Th2 responses by microglia and astrocytes.
Aloisi
F
F
The Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Ria
F
F
Adorini
L
L
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001253:Astrocytes / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology; D006801:Humans; D017628:Microglia / Q000276:immunology*; D008954:Models, Biological; D015213:Neuroimmunomodulation; D013601:T-Lymphocytes / Q000276:immunology*