Experimental models of brain trauma.
A short review of the most widely used and popular experimental models of traumatic brain injury is presented. This review focuses on current animal models of traumatic brain injury that apply mechanical energy to the skull or, after trephination of the skull, to the intact dura. Recent experimental studies evaluating the pathobiology of traumatic brain injury using these models are also discussed. This article attempts to provide a broad overview of current knowledge and controversies in experimental animal research on brain trauma.
Laurer
H L
HL
Department of Neurosurgery, School of Medicine, University of Pennsylvania, Philadelphia 19104-6316, USA. laurer@mail.med.upenn.edu
McIntosh
T K
TK
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans