title: Discovery of a new class of selective cyclooxygenase-2 (COX-2) inhibitor that covalently modifies the isozyme.
authors.affiliation: A. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Kalgutkar
authors.forename: B C
authors.initials: BC
authors.lastname: Crews
authors.forename: S W
authors.initials: SW
authors.lastname: Rowlinson
authors.forename: C
authors.initials: C
authors.lastname: Garner
authors.forename: L J
authors.initials: LJ
authors.lastname: Marnett
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D000480:Alkynes; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D020134:Catalytic Domain; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000145:classification* / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000494:pharmacology*; D013058:Mass Spectrometry; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry* / Q000494:pharmacology*; D012756:Sheep; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000480:Alkynes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D013440:Sulfides; C112390:o-(acetoxyphenyl)hept-2-ynyl sulfide; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D000114:Acetylene; D001241:Aspirin