title: Requirement for homologous recombination functions for expression of the mutA mistranslator tRNA-induced mutator phenotype in Escherichia coli.
abstract: Expression of the Escherichia coli mutA mutator phenotype requires recA, recB, recC, ruvA, and ruvC gene, but not recD, recF, recO, or recR genes. Thus, the recBCD-dependent homologous recombination system is a component of the signal pathway that activates an error-prone DNA polymerase in mutA cells.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey 07103-2714, USA.
authors.forename: L
authors.initials: L
authors.lastname: Ren
authors.forename: A A
authors.initials: AA
authors.lastname: Al Mamun
authors.forename: M Z
authors.initials: MZ
authors.lastname: Humayun
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000235:genetics; D004706:Endodeoxyribonucleases / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins; D043211:Exodeoxyribonuclease V; D005090:Exodeoxyribonucleases / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D012343:RNA, Transfer / Q000096:biosynthesis*; D011938:Rec A Recombinases / Q000235:genetics; D011995:Recombination, Genetic / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; C069806:ruvC protein, E coli; D012343:RNA, Transfer; D011938:Rec A Recombinases; D004706:Endodeoxyribonucleases; D005090:Exodeoxyribonucleases; D043211:Exodeoxyribonuclease V; C468322:exodeoxyribonuclease V, E coli; C071059:Holliday junction DNA helicase, E coli; D004265:DNA Helicases