Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice.
Oral administration of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652), a nucleoside analog structurally similar to lamivudine (3TC), caused dose-dependent inhibition of viral replication in SCID-hu Thy/Liv mice infected with human immunodeficiency virus type 1 NL4-3 and with an NL4-3 clone containing the M184V mutation in reverse transcriptase that confers resistance to 3TC. These experiments demonstrate the utility of this mouse model for evaluating drug resistance and for performing direct comparisons between antiviral compounds in vivo.
Stoddart
C A
CA
Antiviral Drug Research Division, Gladstone Institute of Virology and Immunology, San Francisco, California, USA. cstoddart@gladstone.ucsf.edu
Moreno
M E
ME
Linquist-Stepps
V D
VD
Bare
C
C
Bogan
M R
MR
Gobbi
A
A
Buckheit
R W
RW
Bedard
J
J
Rando
R F
RF
McCune
J M
JM
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004195:Disease Models, Animal; D004352:Drug Resistance, Microbial; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000821:virology; D051379:Mice; D016513:Mice, SCID; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D013872:Thionucleosides / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
C120719:2'-deoxy-3'-oxa-thiocytidine; D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D013872:Thionucleosides; D003841:Deoxycytidine; D019259:Lamivudine; D054303:HIV Reverse Transcriptase