title: Indinavir concentrations and St John's wort.
abstract: St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.
authors.forename: S C
authors.initials: SC
authors.lastname: Piscitelli
authors.forename: A H
authors.initials: AH
authors.lastname: Burstein
authors.forename: D
authors.initials: D
authors.lastname: Chaitt
authors.forename: R M
authors.initials: RM
authors.lastname: Alfaro
authors.forename: J
authors.initials: J
authors.lastname: Falloon
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004351:Drug Resistance; D005260:Female; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D006801:Humans; D020902:Hypericum / Q000009:adverse effects*; D019469:Indinavir / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal; D017211:Treatment Failure
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir