title: Humoral response in a patient with cutaneous nocardiosis.
abstract: The clinical appearance of infection due to Nocardia spp. varies widely. The low sensitivity of direct microscopy and the slow growth of the organism challenge the laboratory diagnosis. We present the case of a skin abscess in an immunocompetent man caused by Nocardia brasiliensis. Diagnosis was made by cultivation and 16S rRNA sequencing. Using indirect immunofluorescence and Western blot, a strong antibody response to the N. brasiliensis isolate could be demonstrated. Serological tests might therefore be useful for the diagnosis and management of nocardial infections.
authors.affiliation: Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilian University, Munich, Germany.
authors.forename: M W
authors.initials: MW
authors.lastname: Hornef
authors.forename: A
authors.initials: A
authors.lastname: Gandorfer
authors.forename: J
authors.initials: J
authors.lastname: Heesemann
authors.forename: A
authors.initials: A
authors.lastname: Roggenkamp
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D000917:Antibody Formation; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009615:Nocardia / Q000276:immunology / Q000302:isolation & purification; D009617:Nocardia Infections / Q000276:immunology* / Q000473:pathology; D017192:Skin Diseases, Bacterial / Q000276:immunology* / Q000473:pathology
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M