title: Production of a family of kinase-inhibiting lactones from fungal fermentations.
abstract: During the course of our screening for natural products from fungi, extracts of several cultures were found to make a family of related resorcylic acid lactone compounds, which are potent inhibitors of MEK kinase. Comparative and empirical studies of fermentation conditions improved the titers of the compounds of interest. Striking changes in the ratios and amounts of the major and minor compounds in some cases were achieved by manipulations of media composition.
authors.affiliation: Merck Research Laboratories, Rahway, NJ 07065, USA.
authors.forename: A
authors.initials: A
authors.lastname: Dombrowski
authors.forename: R
authors.initials: R
authors.lastname: Jenkins
authors.forename: S
authors.initials: S
authors.lastname: Raghoobar
authors.forename: G
authors.initials: G
authors.lastname: Bills
authors.forename: J
authors.initials: J
authors.lastname: Polishook
authors.forename: F
authors.initials: F
authors.lastname: Peláez
authors.forename: B
authors.initials: B
authors.lastname: Burgess
authors.forename: A
authors.initials: A
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Goetz
mesh_terms: D003470:Culture Media; D004791:Enzyme Inhibitors / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D007783:Lactones / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*
chemical_list: D003470:Culture Media; D004791:Enzyme Inhibitors; D007783:Lactones; D017346:Protein Serine-Threonine Kinases