Effect of chronic cyanide intoxication on memory in albino rats.
Cyanide is a chemical widely used in industry, and is a major environmental pollutant. Its toxicity is caused by inhibition of cytochrome oxidase resulting in histotoxic hypoxia. The effect of sublethal doses of cyanide on memory and hippocampal neurotransmitters was studied in male Wistar strain albino rats. Cyanide reduced the memory along with reduction in the levels of dopamine and 5-hydroxytryptamine in the hippocampus. Pre-existing malnutrition in the animals exaggerated these effects.
Mathangi
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Department of Physiology, Dr. ALM. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Madras 600 113, India.
Namasivayam
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D000818:Animals; D003486:Cyanides / Q000494:pharmacology / Q000633:toxicity*; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008568:Memory / Q000187:drug effects*; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism
D003486:Cyanides; D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine