Management protocol for abacavir-related hypersensitivity reaction.
OBJECTIVE
To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center.


RESULTS
Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions.


RESULTS
Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for clinicians.


CONCLUSIONS
Abacavir, a newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure.
Clay
P G
PG
Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, USA. pclay@cctr.umkc.edu
Rathbun
R C
RC
Slater
L N
LN
D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000075202:Contraindications; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000628:therapy*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D000099227:Abacavir