Activity of foot skin mechanoreceptors and afferent nerve fibres in the adult rat sciatic nerve are altered after central axotomy of sensory neurons.
The functional properties of skin mechanoreceptors were examined in the hind foot of normal rats in comparison with animals subjected to dorsal rhizotomy. Evoked nerve impulses were recorded from afferent nerve fibres of the tibial nerve. The decentralized mechanoreceptors displayed evidence of autonomous functioning, but with several abnormalities as compared to normal animals. There was a decreased sensitivity to mechanical stimulation and a lower adaptive capacity as a consequence of rhizotomy. The underlying mechanism is suggested to be a loss of central trophic support because of the interrupted link between the central nervous system and the sensory ganglion cell periphery. The findings indicate that mechanical receptors continue functioning under conditions when sensory impulses flow cannot reach postsynaptic target neurons in the central nervous system, but stop at the level of the primary sensory neuron.
Kolosova
L I
LI
Laboratory of Physiology of Reception, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova 6, St Petersburg, Russia. lara@infran.ru
Nozdrachev
A D
AD
Akoev
G N
GN
Moiseeva
A B
AB
Riabchikova
O V
OV
D000222:Adaptation, Physiological; D000818:Animals; D019771:Axotomy; D004594:Electrophysiology; D006614:Hindlimb; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology*; D009412:Nerve Fibers / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D019051:Rhizotomy; D012584:Sciatic Nerve / Q000502:physiology*; D012867:Skin / Q000294:innervation*; D013979:Tibial Nerve / Q000502:physiology