Pharmacokinetics and dosage regimen of enrofloxacin in buffalo bulls after intramuscular administration.
The disposition kinetics and dosage regimen of enrofloxacin were investigated in breeding buffalo bulls following a single intramuscular administration of 5 mg/kg. The absorption half-life, half-life of the terminal phase, apparent volume of distribution and total body clearance were 0.262+0.099 h, 1.97+/-0.23 h, 0.61+/-0.13 L/kg and 210.2+/-18.6 ml/(kg.h), respectively. Therapeutic plasma levels (> or = 1 microg/ml) were maintained for up to 6 h. A satisfactory intramuscular dosage regimen for enrofloxacin in buffalo bulls would be 8.5 mg/kg followed by 8.0 mg/kg at 8 h intervals.
Verma
H K
HK
Department of Veterinary and A. H. Extension, College of Veterinary Science, Punjab Agricultural University, Ludhiana, India.
Pangawkar
G R
GR
Chaudhary
R K
RK
Srivastava
A K
AK
D000822:Animal Husbandry; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002020:Buffaloes / Q000378:metabolism*; D004334:Drug Administration Schedule; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D007273:Injections, Intramuscular / Q000662:veterinary; D008297:Male; D015363:Quinolones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin