Influence of the HDL receptor SR-BI on atherosclerosis.
The scavenger receptor class B, type I (SR-BI) is an HDL receptor that mediates selective cholesterol uptake from HDL to cells. In rodents, SR-BI has a critical influence on plasma HDL-cholesterol concentration and structure, the delivery of cholesterol to steroidogenic tissues, female fertility, and biliary cholesterol concentration. SR-BI can also serve as a receptor for non-HDL lipoproteins and appears to play an important role in reverse cholesterol transport. Recent studies involving the manipulation of SR-BI expression in mice, either using adenovirus-mediated or transgenic hepatic overexpression or using homologous recombination for complete functional ablation, indicate that the expression of SR-BI protects against atherosclerosis. If SR-BI has a similar activity in humans, it may become an attractive target for therapeutic intervention.
Krieger
M
M
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA. krieger@mit.edu
Kozarsky
K
K
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D018955:CD36 Antigens / Q000502:physiology*; D002352:Carrier Proteins; D005260:Female; D005298:Fertility; D006801:Humans; D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D051379:Mice; D008822:Mice, Transgenic; D016601:RNA-Binding Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein / Q000502:physiology*; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D018955:CD36 Antigens; D002352:Carrier Proteins; D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D016601:RNA-Binding Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C495124:SCARB1 protein, human; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; C031616:high density lipoprotein receptors; C075197:high density lipoprotein binding protein