title: Scleroderma-like reaction induced by uracil-tegafur (UFT), a second-generation anticancer agent.
abstract: UFT, a combination of uracil and tegafur, is a second-generation anticancer agent. UFT has been used in Japan, other Asian countries, South America, and Russia. Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin. We report a case of a scleroderma-like reaction induced by long-term administration of UFT. This is the first report of UFT-induced scleroderma-like reaction.
authors.affiliation: Department of Dermatology, First Department of Internal Medicine, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kono
authors.forename: M
authors.initials: M
authors.lastname: Ishii
authors.forename: N
authors.initials: N
authors.lastname: Negoro
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000139:chemically induced*; D013274:Stomach Neoplasms / Q000188:drug therapy; D005641:Tegafur / Q000009:adverse effects*; D014498:Uracil / Q000009:adverse effects*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005641:Tegafur; D014498:Uracil