Myxoid liposarcoma with transition to round-cell lesion-cell cycle regulator genes and telomerase activity characterizing tumor progression: a case report.
A mixed myxoid/round cell liposarcoma was macrodissected in its 2 histologic components and investigated for genetic differences between its low-grade myxoid and the high-grade round-cell region. For both, we failed to detect p53 gene mutations, loss of heterozygosity at the p53 or Rb genes, and p53 protein expression. The round-cell component showed a high telomerase activity, and an elevated c-myc mRNA and protein expression. The myxoid component was characterized by a lack of telomerase activity and low c-myc mRNA expression, and immunohistochemistry failed to detect the c-myc protein. There was a higher Mib-1 proliferation index in the round-cell portion. The same specific translocation t(12;16) and the fusion transcript type II in both components confirmed the close relationship between myxoid and round-cell liposarcomas. Telomerase activity and increased c-myc expression seem to be helpful molecular markers for characterizing tumor progression in myxoid liposarcoma.
Jaeger
V
V
Department of Pathology, Otto-von-Guericke University, Magdeburg, Germany.
Schneider-Stock
R
R
Gerresheim
F
F
Epplen
J T
JT
Serra
M
M
Lippert
H
H
Roessner
A
A
D000008:Abdominal Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D034961:Antigens, Nuclear; D002455:Cell Division; D015870:Gene Expression; D018816:Genes, cdc; D016259:Genes, myc; D006801:Humans; D019394:Ki-67 Antigen; D008080:Liposarcoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D018208:Liposarcoma, Myxoid / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D012333:RNA, Messenger / Q000032:analysis; D019098:Telomerase / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D034961:Antigens, Nuclear; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53; D019098:Telomerase