Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system.
The anticancer drug, adriamycin (ADR), was incorporated by physical entrapment into polymeric micelles for selective delivery to a murine solid tumor colon adenocarcinoma 26 (C 26). In vivo antitumor activity of ADR was greatly enhanced by this incorporation into polymeric micelles. Using one polymeric micelle delivery system, the tumor completely disappeared at two doses, while free ADR exhibited a fair inhibition effect on tumor growth only at the maximum tolerated dose. Biodistribution analysis revealed that the physically entrapped micellar ADR accumulated at tumor sites in a highly selective manner. These results indicate that these polymeric micelles are a promising system for delivering hydrophobic anticancer drugs selectively to solid tumor sites using a passive targeting mechanism.
Yokoyama
M
M
Institute of Biomedical Engineering, Tokyo Women's Medical University, Tokyo, Japan. masajun@lab.twmu.ac.jp
Okano
T
T
Sakurai
Y
Y
Fukushima
S
S
Okamoto
K
K
Kataoka
K
K
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004337:Drug Carriers; D005243:Feces / Q000737:chemistry; D005260:Female; D007275:Injections, Intravenous; D008297:Male; D008823:Micelles; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D008823:Micelles; D004317:Doxorubicin