[Moderating action of celiac block in experimental pancreatitis in the dog].
BACKGROUND
Pancreatic ischemia seems to be responsible of transition from edematous to hemorrhagic forms in acute pancreatitis. (AP) Sympathetic system vasoconstriction, through celiac plexus play an important role in the pathogenesis of acute pancreatitis.


OBJECTIVE
Determinate the effects of anesthetic celiac blockade in an experimental model of AP.


METHODS
Distal pancreatectomy and intraductal injection of autologous bile in 28 mongrel dogs. Blockade of celiac plexus with bupivacaine in the experimental group B. Anatomopathologic examination after 72 hours.


RESULTS
Experimental group B developed milder forms of AP, while the control group A developed severe forms.


CONCLUSIONS
Results suggest that celiac plexus blockade with bupivacaine may prevent the development of necrohemorrhagic forms of PA in a canine model.
Pirágine
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Unidad de Medicina Experimental del Hospital Italiano, Buenos Aires. webmaster@hitalba.edu.ar
Mele
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Caramutti
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Justo
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D000208:Acute Disease; D000779:Anesthetics, Local; D000818:Animals; D001340:Autonomic Nerve Block; D002045:Bupivacaine; D002447:Celiac Plexus; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008297:Male; D010195:Pancreatitis / Q000209:etiology / Q000517:prevention & control*
D000779:Anesthetics, Local; D002045:Bupivacaine