Epstein-Barr virus: Co-opting B-cell memory and migration.
Epstein-Barr virus, a B-lymphotropic human herpesvirus, persists in vivo by entering the long-lived memory B-cell compartment. Work with genetically modified mice suggests that the viral latent membrane protein LMP1 might allow infected B cells to access the memory compartment by an unusual route.
Rickinson
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AB
CRC Institute for Cancer Studies, MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, B15 2TT, UK. A.B.Rickinson@bham.ac.uk
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PJ
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000821:virology*; D002465:Cell Movement; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D007156:Immunologic Memory; D051379:Mice; D014763:Viral Matrix Proteins / Q000235:genetics / Q000378:metabolism*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D014763:Viral Matrix Proteins