title: Acute bilateral trigeminal neuropathy associated with nervous system lymphosarcoma in a dog.
abstract: A nine-year-old dog presented with clinical signs consistent with bilateral trigeminal neuropathy. Multicentric lymphoma was diagnosed, and neoplastic lymphocytes were identified in the cerebrospinal fluid. Electromyography revealed spontaneous activity in temporal and masseter muscles. Histopathological examination demonstrated neoplastic cell invasion of temporal and masseter myofibers and of multiple peripheral nerves, including the trigeminal nerve. Central nervous system pathology consisted primarily of spinal root and leptomeningeal lymphoid cell infiltration with relative sparing of spinal cord and brain parenchyma.
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Pfaff
authors.forename: P A
authors.initials: PA
authors.lastname: March
authors.forename: C
authors.initials: C
authors.lastname: Fishman
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D004285:Dogs; D004576:Electromyography / Q000662:veterinary; D017809:Fatal Outcome; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000134:cerebrospinal fluid / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008406:Masseter Muscle / Q000473:pathology / Q000503:physiopathology; D009423:Nervous System Neoplasms / Q000134:cerebrospinal fluid / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D013703:Temporal Muscle / Q000473:pathology / Q000503:physiopathology; D020433:Trigeminal Nerve Diseases / Q000209:etiology / Q000662:veterinary*