Effect of low-dose aspirin on the markers of oxidative stress.
The present study estimates effects of low-dose enteric coated aspirin (ECA) on oxidative stress (OS) markers in a group of middle-aged men (mean age 51.2 +/- 6.9 years) free of pre-existing ischemic heart disease.


METHODS
Serum products of lipid peroxidation, and measures of antioxidative status were detected in 25 healthy men in baseline and after two-week treatment period.


RESULTS
In respect to serum products of lipid peroxidation and markers of antioxidant status, no statistically significant differences between the pre- and after-treatment data were observed for any measures, with the exception of values of serum antioxidative capacity (39.0 +/- 2.5 and 42 +/- 4.6, respectively).


CONCLUSIONS
Administration of ECA does not initiate the OS in blood and improves the general antioxidative potency of blood. This may imply towards certain antiatherogenic influence of low-dose ECA, exhibited even with a short-term treatment period. Regarding OS markers, a variety of individual responses observed in the selected subgroups should be investigated and possibly taken into account while treatment with ECA is initiated for primary prevention of cerebrovascular events.
Ristimäe
T
T
Department of Cardiology, Faculty of Medicine, University of Tartu, Estonia. tiinar@cut.ee
Zilmer
M
M
Zilmer
K
K
Kairane
C
C
Kullisaar
T
T
Teesalu
R
R
D000328:Adult; D000975:Antioxidants / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D013608:Tablets, Enteric-Coated
D000975:Antioxidants; D015415:Biomarkers; D008055:Lipids; D013608:Tablets, Enteric-Coated; D001241:Aspirin