title: [Relationship between pregnancy loss and antiphospholipid antibody].
abstract: OBJECTIVE
  To investigate the relationship between history of pregnancy loss and antiphospholipid antibodies (APA), including anticardiolipin (ACA) and lupus anti-coagulant antibodies (LA).
  
  
  METHODS
  Levels of serum APA, ACA and LA were determined by enzyme linked immunoabsorbent assay and activated partial thromboplastin time method respectively in 122 patients with history of unexplained pregnancy loss (study group) and 100 normal nonpregnant women (control group). The study group was further divided into three subgroups: embryo growth arrest (n = 23), stillbirth (n = 31), and recurrent abortion (n = 63).
  
  
  RESULTS
  The positive rates of APA, ACA, LA in the study group were significantly higher than those in controls (P < 0.05-0.001). The above significance was true in both stillbirth and recurrent abortion groups but not in embryo growth arrest group.
  
  
  CONCLUSIONS
  Levels of serum APA were associated with pregnancy loss, especially recurrent abortion and stillbirth. We suggested routine screening of serum APA should be performed in patients with history of fetal wastage for the sake of early treatment.
authors.affiliation: First Hospital of Dalian Medical University.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Qian
authors.forename: S
authors.initials: S
authors.lastname: Liu
mesh_terms: D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005313:Fetal Death / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D011247:Pregnancy
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor