Formulation of a neutral solution of ciprofloxacin upon complexation with aluminum.
Clear solutions of 0.5 and 1.0% ciprofloxacin (CF) of pH 7.2 were prepared by the addition of aluminum chloride hexahydrate (AlCl3.6H2O) in the molar proportion CF:AlCl3.6H2O (3:1). Minimum inhibitory concentrations (MIC) of these solutions were the same as an equimolar solution of CF.HCl. Solutions exhibited good physical, chemical and microbiological stability and satisfactorily overcame an ocular irritation test on rabbits.
Allemandi
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DA
Departamento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Argentina. dalemand@dqo.fcq.unc.edu.ar
Alovero
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F
Manzo
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RH
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry*; D002939:Ciprofloxacin / Q000009:adverse effects / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005123:Eye / Q000187:drug effects; D007509:Irritants; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D013211:Staphylococcus aureus / Q000187:drug effects
D000890:Anti-Infective Agents; D007509:Irritants; D002939:Ciprofloxacin