Thrombosis associated with the prothrombin G-->A20210 mutation in Behçet's disease.
We describe 2 cases of Behcet's disease (BD) and thrombosis who were heterozygous for the prothrombin G-->A20210 mutation. In one case, progressive uncontrolled thromboses led to death. Case-control studies are needed to support the hypothesis of the role of the prothrombin A20210 allele as a risk factor for venous thrombosis in some patients with BD.
Salvarani
C
C
Rheumatic Disease Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
Calamia
K
K
Silingardi
M
M
Ghirarduzzi
A
A
Olivieri
I
I
D000328:Adult; D001528:Behcet Syndrome / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis / Q000209:etiology* / Q000235:genetics*
D011516:Prothrombin