Synthesis of 1-amino-6,7,8,8a-tetrahydroacenaphthene and its effect on the inhibition of the MAO-enzyme at the brain cortex and liver level.
(+/-)-1-Amino-6,7,8,8a-tetrahydroacenaphthene was synthesized and evaluated as a novel drug acting on the dopaminergic system. It was shown that the new compound displays activity as MAO inhibitor.
Charris
J
J
Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.
Pérez
J
J
Duerto de Pérez
Z
Z
Companogne
R
R
Ayala
C
C
Stern
A I
AI
Migliore de Angel
B
B
de Báez
E M
EM
Caldera
J
J
Avila
D
D
Angel
J
J
D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology*; D004298:Dopamine / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
C095772:1-amino-6,7,8,8a-tetrahydroacenaphthene; D000073:Acenaphthenes; D008996:Monoamine Oxidase Inhibitors; D004298:Dopamine