title: [Systematic treatment of acute myocardial infarction with primary angioplasty. Early clinical and angiographic results and after 6 months].
abstract: Starting in 1995, at our institution all patients with acute myocardial infarction (AMI) who gave informed consent were treated by primary percutaneous transluminal coronary angioplasty (PTCA) without limitations in entry criteria. This report presents early and six-month clinical and angiographic results of the 720 patients (77% male, median age 64 years) treated by direct PTCA between January 1, 1995 and July 31, 1998. On admission, 33% of patients were in Killip class > 1, and 101 patients (14%) were in early cardiogenic shock. Optimal acute angiographic success (TIMI grade 3 flow with residual stenosis < 30%) was achieved in 683 patients (95%). Primary or unplanned stenting of infarct related artery (IRA) for a suboptimal or poor angiographic result after primary PTCA was performed in 454 patients (63%). The mean time from hospital arrival to recanalization was 62 +/- 28 min. At 30 days, the mortality rate was 4.9% (1.8% in Killip class < 4 patients and 24% in patients with cardiogenic shock). The reinfarction rate was 1.2%. At 30 days, coronary angiography showed restenosis or reocclusion of the IRA in 55 patients (8.9%). During the six-month follow-up (30-180 days), there were 11 deaths (1.5%) and 2 non-fatal reinfarctions (0.3%). At six months, the IRA patency rate was 95%, while the mean ejection fraction improvement in 422 patients with paired ventriculograms was 7%. Recurrent ischemia occurred in 144 patients (20%) and resulted in 7 deaths, 11 non-fatal reinfarctions and 126 repeat targeted vessel revascularization.
  
  
  CONCLUSIONS
  The major finding of our experience is that direct coronary angioplasty may result in excellent early and late outcome in a population without limitations in entry criteria. The low mortality and the few recurrent myocardial ischemic events are connected with the high patency rate at 6 months. The extensive use of stents improves the angiographic results and the clinical outcome.
authors.affiliation: Divisione di Cardiologia Azienda Ospedaliera Careggi, Firenze.
authors.forename: D
authors.initials: D
authors.lastname: Antoniucci
authors.forename: L
authors.initials: L
authors.lastname: Bolognese
authors.forename: P
authors.initials: P
authors.lastname: Buonamici
authors.forename: G
authors.initials: G
authors.lastname: Cerisano
authors.forename: G
authors.initials: G
authors.lastname: Moschi
authors.forename: P
authors.initials: P
authors.lastname: Pucci
authors.forename: G M
authors.initials: GM
authors.lastname: Santoro
authors.forename: M
authors.initials: M
authors.lastname: Trapani
authors.forename: R
authors.initials: R
authors.lastname: Valenti
authors.forename: P F
authors.initials: PF
authors.lastname: Fazzini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000790:Angiocardiography; D015906:Angioplasty, Balloon, Coronary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000628:therapy*; D013997:Time Factors