CD10 positive thyroid marginal zone non-Hodgkin lymphoma.
A 72 year old woman presented with swelling of the right lobe of her thyroid gland. Fine needle aspiration and flow cytometry showed a clonal population of B cells expressing CD10 and a diagnosis of follicle centre cell lymphoma was made. Subsequent excision of the thyroid showed the typical histological features of a marginal zone non-Hodgkin lymphoma. Polymerase chain reaction showed no evidence of t (14;18). Immunohistochemistry confirmed CD10 positivity and LN1 (CDw75) expression. This is only the second report of aberrant expression of CD 10 by a marginal zone lymphoma.
Millar
E K
EK
Department of Anatomical Pathology, John Hunter Hospital, Hunter Region Mail Centre, Lambton, Australia. emillar@doh.health.nsw.gov.au
Waldron
S
S
Spencer
A
A
Braye
S
S
D000368:Aged; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000276:immunology; D015260:Neprilysin / Q000032:analysis*; D016133:Polymerase Chain Reaction; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000276:immunology
D015260:Neprilysin