title: Accuracy of the LocaLisa system in catheter ablation procedures.
abstract: Estimation of the 3-dimensional (3D) position of ablation electrodes from fluoroscopic images is inadequate in the ablation of complex arrhythmogenic substrates. We developed a new technique for real-time 3D localization of intracardiac electrodes. Regular catheter electrodes are used as sensors for a high-frequency transthoracic electrical field, which is applied via standard skin electrodes. We investigated localization accuracy by comparing measured and true interelectrode distances between the tip and the 10th electrode of a decapolar catheter, and the tip and the 4th electrode of a quadripolar catheter during catheter ablation procedures. Long-term stability was analyzed by localization of the proximal His bundle before and after slow pathway ablation. Accuracy achieved with the 54-mm distance between the two outer electrodes of the decapolar catheters was 101% +/- 15%, 95% +/- 10%, and 97% +/- 8% in the right atrium, right ventricle, and left ventricle, respectively. During catheter ablation procedures, the measured distance between the tip and 4th electrode of the mapping catheter was 100% +/- 15% in atrial flutter, 100% +/- 12% in slow pathway ablation, and 100% +/- 14% in ablations for left ventricular tachycardia. After 2 hours, localization of the proximal His bundle was reproducible within 1.4 +/- 1.1 mm. The LocaLisa technique allows for reproducible, real-time nonfluoroscopic 3D visualization of standard mapping and ablation catheters and is sufficiently accurate for the creation of linear radiofrequency lesions. The freedom of catheter choice makes the LocaLisa system an invaluable tool in catheter mapping and ablation procedures.
authors.affiliation: Heart Lung Institute, Department of Cardiology, University Hospital Utrecht, The Netherlands.
authors.forename: F H
authors.initials: FH
authors.lastname: Wittkampf
authors.forename: E F
authors.initials: EF
authors.lastname: Wever
authors.forename: R
authors.initials: R
authors.lastname: Derksen
authors.forename: H
authors.initials: H
authors.lastname: Ramanna
authors.forename: R N
authors.initials: RN
authors.lastname: Hauer
authors.forename: E O
authors.initials: EO
authors.lastname: Robles de Medina
mesh_terms: D001282:Atrial Flutter / Q000503:physiopathology / Q000601:surgery*; D018780:Body Surface Potential Mapping / Q000295:instrumentation*; D017115:Catheter Ablation / Q000295:instrumentation*; D004562:Electrocardiography / Q000295:instrumentation*; D004566:Electrodes; D004867:Equipment Design; D006329:Heart Conduction System / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology / Q000601:surgery*; D017180:Tachycardia, Ventricular / Q000503:physiopathology / Q000601:surgery*