[Expression of the bcl-2 and bax oncoprotein in TCC and its clinical significances].
To investigate the role of bcl-2 (an apoptosis suppressing oncogene) and bax (an apoptosis accelerating oncogene) in the development of TCC. We investigated bcl-2 and bax expression by means of immunohistochemical technique in 34 cases of TCC and in 9 cases of normal bladder tissue. Bcl-2 was positive in 44.44% of normal bladder tissue and in 82.35% of TCC. Bcl-2 staining intensity was significantly stronger in TCC than that in normal bladder tissue. Intensity and positivity of bcl-2 also increased with increasing grades of TCC. Bax was positive in 88.89% of normal bladder tissue and in 52.94% of TCC. Bax staining intensity was significantly weaker in TCC than that in the normal bladder tissue. These results suggested that increased expression of bcl-2 and decreased expression of bax in TCC play an important role in the development of TCC.
Yang
B
B
Institute of Urology, Beijing Medical University.
Gu
F
F
Wang
X
X
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D019254:Genes, bcl-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein