title: Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice.
abstract: BACKGROUND
  In this study, we investigated whether dietary intervention could inhibit tumor growth of an androgen-sensitive human prostatic cancer.
  
  
  METHODS
  LNCaP cells were transplanted subcutaneously in nude-mice. The animals were then put on different diets and tumor take, tumor growth and prostate specific antigen (PSA) secretion were studied during 9 weeks.
  
  
  RESULTS
  Palpable tumors developed in 75% of the tumor-cell injected sites in animals fed a control diet (corn starch, sucrose, etc.) whereas, for animals given rye bran (RB), ethyl acetate extraction from rye bran supplemented cellulose based diets (CCEE), palpable tumors were seen in only 30% and for soy protein based diets (SCC) 50% of the transplantation sites, respectively. The tumors that grew to palpable size in the rye (RB) and soy (SCC) groups were smaller and secreted less PSA than those in the control group. In the rye and soy groups tumor cell apoptosis was increased, but cell proliferation was unaffected. Addition of fat to the rye diet reduced its effect on prostate cancer growth.
  
  
  CONCLUSIONS
  Factors in rye bran and soy protein may inhibit prostate cancer growth. The effect is more apparent for rye than for soy. Further studies are needed to identify the effective substances and to explore the mechanism of action.
authors.affiliation: Department of Oncology, University of Umeå, Umeå, Sweden. Annika.Byland@germed.umu.se
authors.forename: A
authors.initials: A
authors.lastname: Bylund
authors.forename: J X
authors.initials: JX
authors.lastname: Zhang
authors.forename: A
authors.initials: A
authors.lastname: Bergh
authors.forename: J E
authors.initials: JE
authors.lastname: Damber
authors.forename: A
authors.initials: A
authors.lastname: Widmark
authors.forename: A
authors.initials: A
authors.lastname: Johansson
authors.forename: H
authors.initials: H
authors.lastname: Adlercreutz
authors.forename: P
authors.initials: P
authors.lastname: Aman
authors.forename: M J
authors.initials: MJ
authors.lastname: Shepherd
authors.forename: G
authors.initials: G
authors.lastname: Hallmans
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology* / Q000652:urine; D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D004043:Dietary Fiber / Q000008:administration & dosage*; D004044:Dietary Proteins / Q000008:administration & dosage; D004435:Eating; D004968:Estrogens, Non-Steroidal / Q000652:urine; D006801:Humans; D007529:Isoflavones; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009336:Necrosis; D009368:Neoplasm Transplantation; D048789:Phytoestrogens; D028321:Plant Preparations; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000652:urine; D012434:Secale; D030262:Soybean Proteins / Q000008:administration & dosage*
chemical_list: D004043:Dietary Fiber; D004044:Dietary Proteins; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D030262:Soybean Proteins; D017430:Prostate-Specific Antigen