[Relationship between expression of tumor suppressor protein p21 and p53 and cell proliferation in the gastric carcinoma].
To study the relationship between the expressions of tumor supressor protein p21 and p53 and malignant growth of gastric carcinoma, 88 paraffin embedded specimens of gastric carcinoma and gastric ulcer were examined with immunohistochemical method. We found that the expression rate of mutated protein p53 in the gastric carcinoma was about 40% and the expression rate of p21 protein in gastric mucous carcinoma, undifferentiated carcinoma, poorly differentiated carcinoma was obviously low. The expression of PCNA in gastric adenoid cancer was very high. The results suggest that the low expression of p21 proteins and mutation of p53 proteins in gastric cancer cells play a certain role in the morbidity of gastric carcinoma, but its involvement in the malignant growth of gastric carcinoma cells is not obvious.
Huang
J
J
Department of Surgery, Second Affiliated Hospital, Hunan Medical University, Changsha.
Gan
J
J
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D009154:Mutation; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis; D016283:Proto-Oncogene Proteins p21(ras) / Q000096:biosynthesis*; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D013276:Stomach Ulcer / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)