Suppressor cells in demyelinating disease: a new paradigm for the new millennium.
This brief review highlights investigations conducted over the past three decades concerning the role of suppressor T cells in the regulation of experimental autoimmune encephalomyelitis (EAE). In addition, more recent studies are summarized which suggest that apoptosis of autoreactive T cells is also involved in the regulation of EAE. The possibility that natural killer (NK) cells mediate apoptosis is also considered.
Lenz
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Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA. rswanbo@med.wayne.edu
Swanborg
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D000818:Animals; D017209:Apoptosis / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors