title: Verification and modification of the ICRP-67 model for plutonium dose calculation.
abstract: On the basis of the available data and empirical expressions for the plutonium excretion after injection, an age-related compartmental model has been developed. It provides a better agreement with measured urinary excretion data than the current ICRP 67 model. Moreover, the revised model avoids unphysiological assumptions such as the transfer of activity from soft tissue to urinary bladder, that were part of the ICRP model. The new predictions of the activity in feces and in blood after an injection are closer to the available data than the ICRP 67 estimations and there is also a good agreement with the partitioning of plutonium between skeleton and liver obtained from different autopsy studies. Furthermore, the urinary excretion estimated by the improved model has been checked using some data from occupationally exposed individuals. As the plutonium uptake in these workers occurred by inhalation, the improved model and the ICRP 67 model were compared by connecting them to the ICRP 66 respiratory tract model. The improved model consistently yields a better agreement with the measured excretion and higher estimations of intake than the ICRP 67 model.
authors.affiliation: Forschungszentrum Karlsruhe, Hauptabteilung, Sichereit/Strahlenschutz, Germany. luciani@hs.fzk.de
authors.forename: A
authors.initials: A
authors.lastname: Luciani
authors.forename: E
authors.initials: E
authors.lastname: Polig
mesh_terms: D001822:Body Burden; D003627:Data Interpretation, Statistical; D006283:Health Physics; D006801:Humans; D007390:International Agencies; D008954:Models, Biological; D011005:Plutonium / Q000032:analysis* / Q000493:pharmacokinetics / Q000652:urine; D011874:Radiometry / Q000706:statistics & numerical data; D014018:Tissue Distribution
chemical_list: D011005:Plutonium