title: Accessory molecules for MHC class II peptide loading.
abstract: Accessory molecules, such as HLA-DM and invariant chain, modulate the ligands bound to MHC class II molecules in antigen-presenting cells. Recent investigations, including gene targeting experiments, have shed light on the functions of these molecules, their mechanisms of action, interactions with class II molecules, and the relationships with associated molecules such as tetraspanins and HLA-DO.
authors.affiliation: Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305-5208, USA. rbusch@leland.stanford.edu
authors.forename: R
authors.initials: R
authors.lastname: Busch
authors.forename: R C
authors.initials: RC
authors.lastname: Doebele
authors.forename: N S
authors.initials: NS
authors.lastname: Patil
authors.forename: A
authors.initials: A
authors.lastname: Pashine
authors.forename: E D
authors.initials: ED
authors.lastname: Mellins
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006681:HLA-D Antigens / Q000276:immunology / Q000378:metabolism; D015803:HLA-DR3 Antigen / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D011485:Protein Binding
chemical_list: D000944:Antigens, Differentiation, B-Lymphocyte; C416186:H-2O antigen; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; C046148:HLA-DO antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; C045084:invariant chain