title: Prognostic factors in patients with differentiated thyroid carcinoma.
abstract: OBJECTIVE
  To study the prognostic factors in patients with differentiated thyroid carcinoma.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  University hospital, Germany.
  
  
  METHODS
  139 consecutive patients who underwent surgery for follicular (n = 42) and papillary thyroid carcinoma (n = 97).
  
  
  METHODS
  Survival rate, type of operation (systematic lymphadenectomy or no lymphadenectomy).
  
  
  RESULTS
  Median observation time was 72 months (range 1-203). The 5 and 10 year survival rates in patients with papillary carcinoma were 92% and 89% respectively, and in those with follicular carcinoma 88% and 80%, respectively. Prognostic factors for papillary carcinoma were distant metastases, age, and extrathyroidal growth, and for follicular carcinoma they were distant metastases, extrathyroidal extension, and multifocal growth. The Union International contre le Cancer and European Organisation for Research and Treatment of Cancer scores and the age, grade, extent and size score were all highly significant. The extent of lymphadenectomy, primary or secondary thyroidectomy, and partial or total thyroidectomy did not influence survival.
  
  
  CONCLUSIONS
  Staging and score systems may be helpful in calculating prognosis in differentiated thyroid carcinoma, but the benefit of systematic lymphadenectomy remains controversial.
authors.affiliation: Department of Surgery, Virchow-Clinic, Humboldt University, Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Steinmüller
authors.forename: J
authors.initials: J
authors.lastname: Klupp
authors.forename: N
authors.initials: N
authors.lastname: Rayes
authors.forename: F
authors.initials: F
authors.lastname: Ulrich
authors.forename: S
authors.initials: S
authors.lastname: Jonas
authors.forename: K J
authors.initials: KJ
authors.lastname: Gräf
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D013997:Time Factors