title: Synthesis of 1-amino-6,7,8,8a-tetrahydroacenaphthene and its effect on the inhibition of the MAO-enzyme at the brain cortex and liver level.
abstract: (+/-)-1-Amino-6,7,8,8a-tetrahydroacenaphthene was synthesized and evaluated as a novel drug acting on the dopaminergic system. It was shown that the new compound displays activity as MAO inhibitor.
authors.affiliation: Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Caracas, Venezuela.
authors.forename: J
authors.initials: J
authors.lastname: Charris
authors.forename: J
authors.initials: J
authors.lastname: Pérez
authors.forename: Z
authors.initials: Z
authors.lastname: Duerto de Pérez
authors.forename: R
authors.initials: R
authors.lastname: Companogne
authors.forename: C
authors.initials: C
authors.lastname: Ayala
authors.forename: A I
authors.initials: AI
authors.lastname: Stern
authors.forename: B
authors.initials: B
authors.lastname: Migliore de Angel
authors.forename: E M
authors.initials: EM
authors.lastname: de Báez
authors.forename: J
authors.initials: J
authors.lastname: Caldera
authors.forename: D
authors.initials: D
authors.lastname: Avila
authors.forename: J
authors.initials: J
authors.lastname: Angel
mesh_terms: D000073:Acenaphthenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000201:enzymology*; D004298:Dopamine / Q000502:physiology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
chemical_list: C095772:1-amino-6,7,8,8a-tetrahydroacenaphthene; D000073:Acenaphthenes; D008996:Monoamine Oxidase Inhibitors; D004298:Dopamine