title: Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo.
abstract: Escherichia coli biofilms on two polyethylene disks were implanted subcutaneously into rabbits receiving systemic gentamicin. Ultrasound was applied for 24 h to one disk. Both disks were removed, and viable bacteria were counted. Pulsed ultrasound significantly reduced bacterial viability below that of nontreated biofilms without damage to the skin.
authors.affiliation: Department of Microbiology, Brigham Young University, Provo, Utah.
authors.forename: A M
authors.initials: AM
authors.lastname: Rediske
authors.forename: B L
authors.initials: BL
authors.lastname: Roeder
authors.forename: J L
authors.initials: JL
authors.lastname: Nelson
authors.forename: R L
authors.initials: RL
authors.lastname: Robison
authors.forename: G B
authors.initials: GB
authors.lastname: Schaalje
authors.forename: R A
authors.initials: RA
authors.lastname: Robison
authors.forename: W G
authors.initials: WG
authors.lastname: Pitt
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D004927:Escherichia coli Infections / Q000382:microbiology; D005839:Gentamicins / Q000494:pharmacology*; D016459:Prosthesis-Related Infections / Q000382:microbiology; D011817:Rabbits; D014465:Ultrasonics
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins