[The biological significance of the genetically determined Se-se human blood group and its effect on the antibody formation process in donors immunized with staphylococcal anatoxin].
82 blood donors have been observed, 63 of them were immunized. Blood group ABO(H), secreting group Se--se and Staphylococcus antibody contents (anti-alpha-staphylolysins) were determined in all the donors. It was found out that the donors-secretors with A(II) blood group exhibited the antibody-production increasing. It is supposed that the secreting of group-specific substance A, that has structural elements similar those of staphylococcus into saliva promotes antibody production increase against staphylococcus. The mechanism of such specific stimulation remains to be unknown and requires further studying.
Patoka
V V
VV
Research Institute of Blood Transfusion, Ministry of Public Health of Ukraine, Kyiv.
D000017:ABO Blood-Group System / Q000235:genetics / Q000276:immunology*; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis*; D001782:Blood Donors; D006460:Hemolysin Proteins / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D007114:Immunization; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis; D012463:Saliva / Q000276:immunology; D013208:Staphylococcal Toxoid / Q000276:immunology*
D000017:ABO Blood-Group System; D000907:Antibodies, Bacterial; D006460:Hemolysin Proteins; D007136:Immunoglobulins; D013208:Staphylococcal Toxoid; C006603:antistaphylolysin