title: AIDS- and non-AIDS-related PML association with distinct p53 polymorphism.
abstract: A population-based analysis of progressive multifocal leukoencephalopathy (PML) showed PML frequencies of 5.1% among patients with AIDS and 0.07% among patients with hematologic malignancies, but similar clinical features of PML in both groups. Sequencing of the p53 gene, exon 4, showed heterozygosity (Arg-Pro) at codon 72 in five of six PML patients. These findings indicate that frequencies of non-AIDS- and AIDS-related PML differ markedly but p53 polymorphisms may influence the occurrence of PML in both groups.
authors.affiliation: Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Power
authors.forename: J G
authors.initials: JG
authors.lastname: Gladden
authors.forename: W
authors.initials: W
authors.lastname: Halliday
authors.forename: M R
authors.initials: MR
authors.lastname: Del Bigio
authors.forename: A
authors.initials: A
authors.lastname: Nath
authors.forename: W
authors.initials: W
authors.lastname: Ni
authors.forename: E O
authors.initials: EO
authors.lastname: Major
authors.forename: J
authors.initials: J
authors.lastname: Blanchard
authors.forename: M
authors.initials: M
authors.lastname: Mowat
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53