Asymmetric division of Drosophila neural stem cells: a basis for neural diversity.
Recent studies of Drosophila neural precursor cells have unveiled the essential roles played by asymmetric cell divisions in the determination of cell fates during neural development. Our understanding now extends to the molecular nature of the cell polarity that underlies asymmetric divisions. This polarity is conserved among neural stem cells, epithelial cells and fertilized eggs.
Matsuzaki
F
F
CREST, Japan Science and Technology Corporation, Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, 980-8575, Japan. fumio@idac. tohoku.ac.jp
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D016764:Cell Polarity; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology; D017124:Conserved Sequence; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D012333:RNA, Messenger