Efficacy of SCH56592 in a rabbit model of invasive aspergillosis.
SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.
Kirkpatrick
W R
WR
Departments of Medicine, San Antonio, Texas 78284, USA. KIRKPATRICK@UTHSCSA.EDU
McAtee
R K
RK
Fothergill
A W
AW
Loebenberg
D
D
Rinaldi
M G
MG
Patterson
T F
TF
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D001230:Aspergillus / Q000302:isolation & purification; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D005260:Female; D007165:Immunosuppression Therapy; D017964:Itraconazole / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D014230:Triazoles / Q000627:therapeutic use*
D000935:Antifungal Agents; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000666:Amphotericin B