Fibroblast growth factor and hydrocephalus.
The immunohistochemical localization of basic fibroblast growth factor (bFGF) was studied in ventricular ependyma and choroid plexus of aged-matched normotensive and spontaneously hypertensive rats at different ages using a polyclonal antibody against bFGF. The bFGF-like immunoreactivity was observed in brain ependyma and choroid plexus of young and old normotensive rats. However, a progressive loss of immunoreactivity was observed with age in spontaneously hypertensive rats, that was associated with a progressive cerebroventricular dilation. These results show a new neuroendocrine anomaly to be added to the many others previously observed in this rat strain, when they develop hydrocephalus as they age.
Cuevas
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Servicio de Histologia, Hospital Ramón y Cajal, Madrid, Spain.
Giménez-Gallego
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D000375:Aging; D000818:Animals; D002552:Cerebral Ventricles / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology; D002831:Choroid Plexus / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology*; D004805:Ependyma / Q000254:growth & development / Q000502:physiology / Q000503:physiopathology*; D016222:Fibroblast Growth Factor 2 / Q000032:analysis / Q000378:metabolism*; D006849:Hydrocephalus / Q000503:physiopathology*; D006973:Hypertension / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values
D016222:Fibroblast Growth Factor 2