title: Elucidation of protein-protein interactions using chemical cross-linking or label transfer techniques.
abstract: Understanding the architectures of multiprotein complexes is a central problem in biology. Of the many chemical methods available, label transfer and cross-linking are becoming more popular. Recently, label transfer has been applied to very large protein complexes with great success, and new oxidative methods for protein cross-linking have been developed that are fast and highly efficient. Advances in these techniques should increase the understanding of biological structures and mechanisms.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA. fancy@chop.swmed.edu.
authors.forename: D A
authors.initials: DA
authors.lastname: Fancy
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry*; D015335:Molecular Probes; D019920:Photoaffinity Labels; D011506:Proteins / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D015335:Molecular Probes; D019920:Photoaffinity Labels; D011506:Proteins