[The effects of hypertonic saline/mannitol resuscitation on the myocardiac contractility and blood pressure of rabbits with hemorrhagic shock].
Eighteen healthy adult male rabbits were hemorrhaged to shock and treated with hypertonic-hyperoncotic solutions in 3 groups (6 per group): hypertonic saline/dextran(HSD), hypertonic saline/mannitol(HSM) and hypertonic acetate/mannitol(HAM). The results showed that HSM. HAM and HSD could raise the left ventricular pressure(LVP), maximum change rate of LVP (+/- dp/dt max) and the arterial blood pressure of hemorrhagic shock rabbits quickly at small dose. The efficiency of HSM was better than that of HSD and HAM (P < 0.05), and the time of blood pressure rise was in accordance with that of LVP and +/- dp/dt max, which may partly explain the mechanism of shock resuscitation by hypertonic-hyperoncotic solution.
Huang
Z
Z
Department of Emergency, Xiangya Hospital, Hunan Medical University, Changsha.
Luo
X
X
Tang
A
A
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
D012462:Saline Solution, Hypertonic; D008353:Mannitol