[The characteristics of left ventricular remodelling in hypertensive heart patients and the possibilities for its drug correction].
In 85 patients with mild and moderately severe arterial hypertension presenting with signs of hypertensive heart, processes of remodelling of the left ventricle (LV) of the heart were studied using combined echocardiographic criteria. An evaluation was done of effects of different groups of antihypertensive drugs on the revealed changes in the LV structure and geometry. The patients were divided into four groups depending on the antihypertensive drug taken (atenolol, cozaar, norvask, enalapril). All groups patients were found to derive benefit from a 4-month monotherapy: against the background of normalization of arterial pressure (AP) structural-and-geometric indices for LV have gotten improved together with those for pulmonary gas exchange. The antagonist of receptors to angiotensin-II (cozaar) and the inhibitor of the angiotensin-converting enzyme (enalapril) were found to be the most efficacious drugs in the correction of the revealed disturbances. Improvement in LV geometry and regression of its hypertrophy were not directly related to AP normalization, witch fact indicates that there is no relationship between antihypertensive and cardioreparative activities of the drugs studied.
Iakimenko
E A
EA
Bondar'
V N
VN
Artemenko
A V
AV
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004452:Echocardiography; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D011659:Pulmonary Gas Exchange / Q000187:drug effects / Q000502:physiology; D020257:Ventricular Remodeling / Q000187:drug effects* / Q000502:physiology
D000959:Antihypertensive Agents