[Pretreatment of organophosphate poisoning: potential interests of huperzine A].
Pyridostigmine which is widely used as pretreatment of organophosphate poisoning protects cholinesterases of peripheral nervous system. Other molecules able to also protect the central nervous system are under study and, among them, huperzine A. This paper gives an overview of the current investigations about the efficacy and the innocuity of this molecule (study of the mechanisms of action, biological targets, behavioural manifestations) and brings out its potential interests.
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Centre de Recherches du Service de Santé des Armées, Département de Toxicologie, Unité de Neuropharmacologie, 24, avenue des Maquis du Grésivaudan, F 38702 La Tronche Cedex.
D000470:Alkaloids; D000931:Antidotes / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000037:antagonists & inhibitors; D011041:Poisoning / Q000517:prevention & control*; D012717:Sesquiterpenes / Q000627:therapeutic use*
D000470:Alkaloids; D000931:Antidotes; D002800:Cholinesterase Inhibitors; D009943:Organophosphorus Compounds; D012717:Sesquiterpenes; C050426:huperzine A