[Effect of manganese on the growth and development of rat offspring].
Effects of Manganese exposure to pregnant rats on the growth and development of their offsprings were as follows: (1) the gain of body weight and brain weight in the high dose Mn-exposed offspring was significantly lower but the ratio of brain to body weight was significantly higher; (2) in Morris Water Maze Test, the average latency to find the hidden platform in the high dose Mn-exposed offsprings was obviously reduced during the first 5 days. But on the non-platform test day, a much longer length of swimming in the quadrant in which the hidden platform was located previously, although no difference was found for the total distance between them; (3) the immunoreactivity of glial fibrillary acid protein and the average density of its products in hippocampus of both the low and high dose Mn-exposed groups, especially of the high dose one, was significantly higher than that of the control group.
Zhang
D
D
Guangdong College of Pharmacy, China.
He
X
X
Zhang
W
W
Tan
J
J
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000009:adverse effects*; D008431:Maternal-Fetal Exchange; D018782:Maze Learning; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley
D005904:Glial Fibrillary Acidic Protein; D008345:Manganese