title: Effects of perineural capsaicin treatment on compound action potentials of superior laryngeal nerve afferents in sevoflurane-anesthetized dogs.
abstract: Effects of perineural capsaicin (CAPS) treatment on compound action potentials of the superior laryngeal nerve (SLN) afferents were studied in 6 sevoflurane-anesthetized dogs. Perineural CAPS (100 microg/ml) to the bilateral SLNs reduced (P<0.01) the peak and integral amplitudes of the C-wave of the compound action potential. By contrast, the perineural CAPS had no effect on the A-wave component (P>0.05). Removal of the perineural CAPS recovered the C-wave to pretreatment level. The perineural CAPS treatment selectively blocks C-wave compound action potentials of the SLN afferents, providing a useful tool for studies of laryngeal C-fibers in respiratory physiology.
authors.affiliation: Department of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mutoh
authors.forename: A
authors.initials: A
authors.lastname: Kanamaru
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: R
authors.initials: R
authors.lastname: Nishimura
authors.forename: N
authors.initials: N
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Tsubone
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000344:Afferent Pathways / Q000502:physiology; D018685:Anesthetics, Inhalation; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D005260:Female; D007823:Laryngeal Nerves / Q000187:drug effects / Q000502:physiology*; D007830:Larynx / Q000502:physiology / Q000601:surgery; D008297:Male; D008738:Methyl Ethers; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D002211:Capsaicin