title: Dynamics of flow, resistance, and intramural vascular volume in canine coronary circulation.
abstract: Varying coronary volume will vary vascular resistance and thereby have an effect on coronary hemodynamics. Six ventricular septa were isolated from anesthetized dogs, dispersed in a biaxial stretch apparatus at diastolic stress, and perfused artificially with an oxygenated perfluorochemical emulsion at maximal vasodilation. Flow and thickness were measured continuously by an electromagnetic flow probe and sonomicrometer. Pressure was varied sinusoidally around 30, 50, and 70 mmHg with an amplitude of 7.5 mmHg; frequencies ranged between 0.015 and 7 Hz. Bode plots of admittance (flow/pressure) and capacitance (scaled thickness/pressure) were constructed. A two-compartment model was used in which the resistances vary with volume. Realistic values of microvascular compliance ( approximately 0.3 ml x mmHg(-1) x 100 g(-1)) were found. Values 10 times higher were then found when resistances were forced to be constant. We concluded that volume dependence of resistances have to be taken into account when dynamic or static pressure-flow relations are studied and conceal the effect of a large intramyocardial compliance on arterial hemodynamics.
authors.affiliation: Department of Medical Physics, Cardiovascular Research Institute Amsterdam, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands. j.a.spaan@amc.uva.nl
authors.forename: J A
authors.initials: JA
authors.lastname: Spaan
authors.forename: A J
authors.initials: AJ
authors.lastname: Cornelissen
authors.forename: C
authors.initials: C
authors.lastname: Chan
authors.forename: J
authors.initials: J
authors.lastname: Dankelman
authors.forename: F C
authors.initials: FC
authors.lastname: Yin
mesh_terms: D000818:Animals; D001810:Blood Volume / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000033:anatomy & histology / Q000502:physiology*; D004285:Dogs; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008955:Models, Cardiovascular; D011312:Pressure; D014655:Vascular Resistance / Q000502:physiology*