title: Dissociation of smooth pursuit and vestibulo-ocular reflex cancellation in SCA-6.
abstract: OBJECTIVE
  To study gaze in SCA-6 patients during pursuit and passive whole-body rotation.
  
  
  BACKGROUND
  Smooth pursuit and vestibularly induced eye movements interact to maintain the accuracy of eye movements in space (i.e., gaze). Previous studies have implicated the cerebellum, particularly the floccular lobe and dorsal vermis, in the control of gaze velocity during pursuit and vestibulo-ocular reflex (VOR) cancellation. SCA-6 has recently been identified genetically and characterized as pure cerebellar ataxia that affects the cerebellar cortex selectively.
  
  
  METHODS
  Using infrared oculography, eye movements of five SCA-6 patients and five age-matched normal control subjects were recorded during sinusoidal pursuit and passive whole-body rotation in the horizontal plane (amplitude, +/- 10 deg; frequency, 0.2 Hz). Eye and gaze gain (eye and gaze velocity/stimulus velocity) were calculated after deleting saccades.
  
  
  RESULTS
  Eye gain of all SCA-6 patients during pursuit was significantly lower than those of the control subjects (mean +/- SD, 0.26+/-0.06 versus 0.91+/-0.07). In contrast, eye gain of the patients was not significantly different from that of the control subjects either during VOR cancellation, when the subjects tracked a target that moved with the same amplitude and phase, like a chair (0.21+/-0.05 versus 0.12+/-0.07), or during visually enhanced VOR (x1), when the target remained stationary in space (0.85+/-0.06 versus 0.95+/-0.05). Moreover, there was no significant difference in mean VOR gain in total darkness between the two groups. Gaze gain of patients (0.26+/-0.06 versus 0.81+/-0.06) but not control subjects (0.91+/-0.07 versus 0.88+/-0.08), was significantly different during pursuit and VOR cancellation.
  
  
  CONCLUSIONS
  SCA-6 patients show dissociation in the control of gaze tracking during smooth pursuit and VOR cancellation.
authors.affiliation: Department of Otolaryngology, Hokkaido University School of Medicine, Sapporo, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takeichi
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: H
authors.initials: H
authors.lastname: Sasaki
authors.forename: I
authors.initials: I
authors.lastname: Yabe
authors.forename: K
authors.initials: K
authors.lastname: Tashiro
authors.forename: Y
authors.initials: Y
authors.lastname: Inuyama
mesh_terms: D000328:Adult; D006801:Humans; D008875:Middle Aged; D011698:Pursuit, Smooth / Q000502:physiology*; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D013132:Spinocerebellar Degenerations / Q000235:genetics / Q000503:physiopathology*