Measles IgA in the nasal washings of adult volunteers and children immunized intranasally with measles vaccine L-16.
Earlier it was determined that inspiration of aerosolized measles vaccines may be as effective as its injection in induction of measles antibodies formation. In the beginning of measles infection the measles virus penetrates through mucosa of nose, mouth or eyes of children. So it seems rational to use a nasal spray of measles vaccine to induce "mucosal immunity" in the nasopharinx. Local IgA measles antibodies formation was observed only after measles vaccine spray immunization of 6-7 year old children or adult volunteers. The same level of sera measles antibodies was observed in immunized people after intranasal or subcutaneous measles vaccination. Special investigation of measles vaccination side effects in adults revealed that the injected vaccine suppressed lymphocytes functional capacity much more than when intranasally introduced. Intranasal measles vaccine spray introduction may be a useful method of child revaccination in the process of measles eradication. This method is useful for investigation of "mucosal immunity" in children or adults.
Liashenko
V A
VA
Institute for Viral Preparations, Moscow, Russia.
Krasnova
V P
VP
Youminova
N V
NV
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D006801:Humans; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000032:analysis*; D008457:Measles / Q000517:prevention & control; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D008459:Measles virus / Q000276:immunology*; D017817:Nasal Lavage Fluid / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D007070:Immunoglobulin A; D008458:Measles Vaccine