title: Generalized pruritic eruption with suprabasal acantholysis preceeding the development of bullous pemphigoid.
abstract: We report a patient who presented with a papular pruritic eruption of a 3-month duration that histologically showed suprabasal acantholysis accompanied of an eosinophilic inflammatory infiltrate that was consistent with the diagnosis of Grover's disease. Later, erythematous plaques and vesicles appeared which showed a histopathological pattern of eosinophilic spongiosis. The direct immunofluorescence (DIF) study showed lineal IgG and C'3 at the dermal epidermal junction which was consistent with the diagnosis of bullous pemphigoid. No anti-intercellular deposits of immunoglobulin G (IgG) or C'3 were observed. We consider that suprabasal acantholysis may represent the early phase of bullous pemphigoid.
authors.affiliation: Department of Dermatology, Hospital de la Sta. Creu i St. Pau, Barcelona, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Barnadas
authors.forename: R M
authors.initials: RM
authors.lastname: Pujol
authors.forename: R
authors.initials: R
authors.lastname: Curell
authors.forename: X
authors.initials: X
authors.lastname: Matías-Guiu
authors.forename: A
authors.initials: A
authors.lastname: Alomar
mesh_terms: D000051:Acantholysis / Q000276:immunology / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004817:Epidermis / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D010391:Pemphigoid, Bullous / Q000276:immunology / Q000473:pathology*; D011537:Pruritus / Q000276:immunology / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G