title: [The value of evaluating tumor markers: CA 15-3 and ferritin in blood serum of patients grouped as "high risk" for breast cancer].
abstract: We studied 127 patients. 35 patients (group I) with mastopathy disease (average 44.3 years old) included 9 patients with a breast cancer family history (subgroup I A), 26 patients without a breast cancer family history (subgroup I B) and 92 patients (group II) with a breast cancer of I-IV grade (average 49.25 years old). The results of the study revealed statistically significant higher level of CA 15-3 in serum of patients with mastopathy compared to patients with a breast cancer of I grade (p < 0.05). CA 15-3 level in patients with a breast cancer of III, IV grade in serum, was considerably higher and there was significant difference comparing to the patients with a breast cancer of I, II grade (p < 0.001) and patients with mastopathy disease. There were also higher average levels of CA 15-3 in patients with mastopathy disease with a breast cancer family history (subgroup I A) compared to patients without an oncological risk (subgroup I B), however there were not significant differences. There were also higher average levels of ferritin revealed in patients with a breast cancer of III, IV grade and which shows significant difference between patients with breast cancer of I, II grade and with mastopathy patients (p < 0.001). It seems that determination of CA 15-3 and ferritin in patients of a high risk group of a breast cancer could be a useful diagnostic tool for early determination of a breast cancer.
authors.affiliation: Samodzielnej Pracowni Immunodiagnostyki Klinicznej, Szpital Górniczy w Sosnowcu.
authors.forename: D
authors.initials: D
authors.lastname: Kokocińska
authors.forename: E
authors.initials: E
authors.lastname: Widala
authors.forename: J
authors.initials: J
authors.lastname: Donocik
authors.forename: E
authors.initials: E
authors.lastname: Nolewajka
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D001941:Breast Diseases / Q000097:blood / Q000175:diagnosis; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D018570:Risk Assessment
chemical_list: D014408:Biomarkers, Tumor; D018396:Mucin-1; D005293:Ferritins