Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer.
OBJECTIVE
In this study we examine the combined effects of Western diet, age at diagnosis, and genetic susceptibility.


METHODS
We use data collected as part of an incident case-control study of colon cancer. Family history of colorectal cancer, N-acetyltransferase (NAT2), and glutathione-S-transferase (GSTM-1) are studied with Western diet and age at diagnosis.


RESULTS
A significant interaction between age at time of diagnosis, Western dietary pattern, and family history of colorectal cancer (p for interaction = 0.03) was detected. Those with a family history of colorectal cancer who ate a predominantly Western diet were at increased risk of colon cancer (OR 14.0, 95% CI 3.9-50.1 for < or = 55 years; OR 7.7, 95% CI 2.0-29.1 for 56-66 years; OR 1.6, 95% CI 0.8-3.2 for > or = 67 years) compared to those without a family history of colorectal cancer and low levels of a Western diet. Associations with the Western diet were stronger than individual components of the dietary pattern. Neither NAT2 nor GSTM-1 showed significant interaction with Western diet.


CONCLUSIONS
The extent to which diet comprising a Western dietary pattern influences risk of colon cancer is dependent on age. This dietary pattern also appears to modulate the colon cancer risk associated with a family history of colon cancer.
Slattery
M L
ML
Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, USA.
Potter
J D
JD
Ma
K N
KN
Caan
B J
BJ
Leppert
M
M
Samowitz
W
W
D017668:Age of Onset; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000032:analysis / Q000378:metabolism; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000209:etiology* / Q000235:genetics*; D004032:Diet; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012737:Sex Factors
D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase