[Serological study of hepatitis C virus NS5 protein epitopes and their clinical and diagnostic significance].
Three peptides corresponding to the 2295-2317 aa NS5 HCV region and individual parts of this region were synthesized. Antigenic properties of these peptides were investigated. The 2295-2317 aa region contains at least two epitopes of different nature. The full-sized peptide is more promising for the diagnostic studies. Optimal conditions for ELISA with this peptide were defined, allowing the maximum complete utilization of the potentialities of both epitopes.
Kruglov
I V
IV
Znoĭko
O O
OO
Finogenova
M P
MP
Ogienko
O L
OL
Ianina
M V
MV
Sergeeva
N A
NA
Braginskiĭ
D M
DM
Doroshenko
N V
NV
Shibnev
V A
VA
Semiletov
Iu A
IuA
D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000097:blood*; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D017361:Viral Nonstructural Proteins / Q000276:immunology*; D012324:RNA-Dependent RNA Polymerase
D000939:Epitopes; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase