title: Serum type IV collagen increases with duration of amyotrophic lateral sclerosis.
abstract: We analyzed the serum levels of type IV collagen, a major component of the basement membrane, during various stages of sporadic amyotrophic lateral sclerosis (ALS). Serum concentrations of type IV collagen increased significantly with the duration of illness. Findings indicate that the metabolism of type IV collagen and the basement membrane may be affected in the disease process of ALS.
authors.affiliation: Department of Internal Medicine (III), Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Houi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Mochio
authors.forename: K
authors.initials: K
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood*; D001485:Basement Membrane / Q000378:metabolism; D015415:Biomarkers; D003094:Collagen / Q000097:blood*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000097:blood
chemical_list: D015415:Biomarkers; D003094:Collagen