Endobronchial radiotherapy for malignant bronchial obstruction or recurrence.
Forty-five lung cancer patients who had recurrence and/or endobronchial obstruction were treated with intrabronchial radiotherapy (IBRT). The majority had been heavily treated previously, mainly by external radiotherapy; six patients were treated surgically. IBRT was given with high-dose-rate equipment, either 18 Gy in three fractions or 15 Gy as a single dose was originally planned. For different reasons several patients received other regimens. Palliation of dyspnoea was obtained in 64% of the patients. Palliation of hemoptysis (12/14) and cough (11/17) was registered, as well as improvement in atelectasis in 11/26 patients. Palliation of dyspnoea was enhanced with an IBRT dose > 15 Gy. The median survival after IBRT was 13 weeks. Fatal hemoptysis (FH) occurred in 12 patients; 10 of these within 6 months after treatment. The risk of FH significantly increased with an IBRT dose > 15 Gy.
Hatlevoll
R
R
Department of Oncology, The Norwegian Radium Hospital, Oslo.
Karlsen
K O
KO
Skovlund
E
E
D001984:Bronchial Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000556:secondary*; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D010166:Palliative Care; D011879:Radiotherapy Dosage; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate