[A trial of amantadine for the treatment of influenza A infection in children].
We administered amantadine to 52 children for therapy and 3 children for prophylaxis of influenza A infection from January to March 1998. Among the 23 children in the therapy group with proven influenza A/H3N2 infection, 15 patients (60%) allayed fever within 3 days but 9 (40%) had persistent fever for more than 4 days after administration of amantadine. Seven of these nine patients (40%) received amantadine within 2 days after the onset of fever. Two of these nine had secondary bacterial infections. One child had insomnia as side effect. We concluded that administration of amantadine for therapy is safe and effective, if given to patients without secondary bacterial infections in the first 48 hours of the illness.
Takeda
N
N
Division of Infectious Diseases, Chiba Children's Hospital.
Kurosaki
T
T
Nakamura
A
A
D000293:Adolescent; D000328:Adult; D000547:Amantadine / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009980:Influenza A virus; D007251:Influenza, Human / Q000188:drug therapy*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*
D000547:Amantadine