Technical report: chronic and acute intracochlear infusion in rodents.
As a follow-up to the Brown et al., 1993 technique, we have made several improvements to the micro-cannula, osmotic pump procedure, enabling chronic intracochlear infusions while maintaining hearing. In addition, acute bolus injection techniques are briefly described in guinea pig, rat and mouse.
Prieskorn
D M
DM
Kresge Hearing Research Institute, The University of Michigan, 1301 E. Ann Street, Ann Arbor, MI 48109-0506, USA.
Miller
J M
JM
D000161:Acoustic Stimulation; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006168:Guinea Pigs; D015918:Infusion Pumps, Implantable; D051379:Mice; D051381:Rats; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012533:Scala Tympani / Q000187:drug effects / Q000502:physiology
D012462:Saline Solution, Hypertonic