Increased arginase activity in aorta of mineralocorticoid-salt hypertensive rats.
The present study was designed, first to investigate aortic arginase activity during the development and the establishment of mineralocorticoid-salt (DOCA-salt) hypertension, and second, to determine the relationship between arginase activity and blood pressure by giving a protein-supplemented diet (50% casein) known to increase hepatic arginase activity. Our results showed that aortic arginase activity in established hypertension of DOCA-salt rats was higher than in normotensive rats. The protein-supplemented diet (50% casein) accelerated the development of DOCA-salt hypertension. There was a positive correlation between arginase activity and the level of blood pressure in these DOCA-salt hypertensive rats fed 50% casein but not in DOCA-salt hypertensive rats on a normal (20% casein) diet. In normotensive rats, the protein-supplemented diet decreased aortic arginase activity and produced no change in systolic blood pressure. Our data suggest that aortic arginase activity is modified in established DOCA-salt hypertension and could participate in the physiopathology of arterial hypertension.
Rodriguez
S
S
Laboratoire de Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, Besançon, France.
Richert
L
L
Berthelot
A
A
D000818:Animals; D001011:Aorta / Q000201:enzymology*; D001119:Arginase / Q000378:metabolism*; D015415:Biomarkers; D001794:Blood Pressure; D001835:Body Weight; D002364:Caseins / Q000633:toxicity; D003900:Desoxycorticosterone / Q000633:toxicity*; D004195:Disease Models, Animal; D006973:Hypertension / Q000139:chemically induced / Q000201:enzymology* / Q000503:physiopathology; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D015415:Biomarkers; D002364:Caseins; D003900:Desoxycorticosterone; D001119:Arginase