title: Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction.
abstract: OBJECTIVE
  To study the early changes of cardiac angiotensin (Ang) II receptor gene transcription after myocardial infarction (MI) in rats chronically treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril.
  
  
  METHODS
  MI was induced by left anterior descending coronary artery ligation in rats and sham-operated rats were used as control. Rats were treated daily with ramipril (1 mg.kg-1) or water, initiated 1 wk before surgery. Quantitative RT-PCR was applied to determine the Ang II receptors AT1, AT2 receptor gene mRNA levels in the non-infarcted myocardium.
  
  
  RESULTS
  AT1 and AT2 mRNA levels increased time point-dependently in the cardiac septum after MI reaching a peak on d 1. There was no significant difference of the myocardial AT1 and AT2 receptor mRNA levels between the ramipril-treated and water-treated rats after MI.
  
  
  CONCLUSIONS
  The AT1 and AT2 receptor gene transcription in the non-infarcted myocardium was associated with the process of cardiac remodeling after MI but not affected by ACE inhibition.
authors.affiliation: Department of Physiology, Shanghai Medical University, China. yczhu@shmu.edu.cn
authors.forename: Y C
authors.initials: YC
authors.lastname: Zhu
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Schäfer
authors.forename: W E
authors.initials: WE
authors.lastname: Schmidt
authors.forename: T
authors.initials: T
authors.lastname: Unger
authors.forename: T
authors.initials: T
authors.lastname: Yao
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D006346:Heart Septum / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D017257:Ramipril / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000096:biosynthesis / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*; D020257:Ventricular Remodeling
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D012333:RNA, Messenger; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D017257:Ramipril