[Long-term development of children with Schönlein-Henoch purpura associated with anti-neutrophil cytoplasmic antibodies].
OBJECTIVE
The purpose of this study was to assess the frequency of antineutrophil cytoplamic antibodies (ANCA) in Schönlein-Henoch purpura (SHP) and its long-term significance.


METHODS
IgG and IgA classes of ANCA were studied by indirect immunofluorescence (IIF) and IgG-ANCA against myeloperoxidase (MPO) and against proteinase-3 (PR-3) were determined by ELISA in 50 children with SHP. Eight (16%) of the patients had renal involvement during the acute phase, but none had a permanent nephropathy after a 7-17 year follow-up.


RESULTS
Positive IgG ANCA were found in 5 (10%) of the cases and only one of these children also had IgA ANCA. The ELISA against MPO and P-3 was negative in all patients. None of the 5 patients with ANCA showed nephropathy during the acute phase nor relapses or permanent nephropathy.


CONCLUSIONS
A minority of children with SHP are positive for ANCA and, in the absence of nephropathy, this is not associated with a bad long-term prognosis.
Blanco Quirós
A
A
Departamento de Pediatría, Hospital Clínico, Universidad de Valladolid.
Conde Redondo
F
F
Solis Sánchez
P
P
Garrote Adrados
J A
JA
Gómez García
S
S
D000208:Acute Disease; D000293:Adolescent; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D008297:Male
D019268:Antibodies, Antineutrophil Cytoplasmic; D007070:Immunoglobulin A; D007074:Immunoglobulin G