How to Make Drugs Orally Active: A Substrate Template for Peptide Transporter PepT1.
By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates of PepT1.
Bailey
PD
Department of Human Anatomy and Genetics University of Oxford, South Parks Road, Oxford, OX1 3QX (UK).
Boyd
CA
Bronk
JR
Collier
ID
Meredith
D
Morgan
KM
Temple
CS