title: Pituitary adenomas treated by microsurgery with or without Gamma Knife surgery: experience in 122 cases.
abstract: The clinical outcome of 122 patients with pituitary adenomas treated by microsurgery and/or Gamma Knife radiosurgery (GKRS) was analyzed to evaluate patient selection criteria and the role of GKRS. Sixty-six resections were performed in 59 patients. All tumors were macroadenomas, except for 5 ACTH-producing adenomas. Twenty-four of the 31 hypersecreting adenomas showed normal serum hormone values after treatment. Postoperative complications were rhinorrhea, cranial nerve palsies, and a small thalamic infarct. GKRS was performed on 18 of the operated patients because of residual tumors, mostly in the cavernous sinus. Thirty-five of the 63 patients treated by GKRS were followed for more than 2 years. All adenomas except 2 were stable or had decreased in size. Eleven of 17 functioning adenomas showed normal serum hormone values after treatment. It is concluded that tumors that compress the optic pathway should be removed and that residual tumors in the cavernous sinus are good indications for radiosurgery.
authors.affiliation: Department of Neurosurgery, Gunma University School of Medicine and Gamma Knife Center, Hidaka Hospital, Gunma, Japan. hkinoue@po.kannet.ne.jp
authors.forename: H K
authors.initials: HK
authors.lastname: Inoue
authors.forename: H
authors.initials: H
authors.lastname: Kohga
authors.forename: M
authors.initials: M
authors.lastname: Hirato
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: J
authors.initials: J
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Shibazaki
authors.forename: C
authors.initials: C
authors.lastname: Ohye
authors.forename: Y
authors.initials: Y
authors.lastname: Andou
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D015175:Prolactinoma / Q000378:metabolism; D016634:Radiosurgery; D012189:Retrospective Studies; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone; D013972:Thyrotropin