title: Pulmonary nocardiosis with cutaneous involvement mimicking a metastasizing lung carcinoma in a patient with chronic myelogenous leukaemia.
abstract: We report a unique case of a man suffering from chronic myelogenous leukaemia who presented with clinical symptoms, X-ray, and bronchoscopical findings consistant with a bronchopulmonary space-occupying process which was suspected to be a central lung carcinoma as a secondary de novo malignancy. In addition, the patient developed several subcutaneous nodular livid red lesions on the left forearm which were considered to be cutaneous metastases of the presumptive lung malignancy. Treatment was started with percutaneous radiation of the mediastinum over a period of ten days with a total dose of 25 Gray. The patient died from circulatory and respiratory failure. Only post mortem pathological examination was indicative of a nocardiosis of the lungs with haematological spread to eosophagus, pleura, and subcutaneous skin of the left forearm. Unfortunately, diagnosis of nocardiosis could not finally proven by culture or molecular biological methods. A lung carcinoma or an infiltrate of residual or relapsing chronic myelogenous leukemia in the lung could be definitely ruled out.
authors.affiliation: Department of Dermatology, University of Leipzig, Liebigstr. 21, D-04103 Leipzig, Germany. nenp@server3.medizin.uni-leipzig.de.
authors.forename: P
authors.initials: P
authors.lastname: Nenoff
authors.forename: S
authors.initials: S
authors.lastname: Kellermann
authors.forename: G
authors.initials: G
authors.lastname: Borte
authors.forename: L C
authors.initials: LC
authors.lastname: Horn
authors.forename: W
authors.initials: W
authors.lastname: Pönisch
authors.forename: J
authors.initials: J
authors.lastname: Winkler
authors.forename: U F
authors.initials: UF
authors.lastname: Haustein
mesh_terms: D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009617:Nocardia Infections / Q000150:complications* / Q000473:pathology; D018410:Pneumonia, Bacterial / Q000150:complications* / Q000000981:diagnostic imaging / Q000532:radiotherapy; D013902:Radiography, Thoracic; D017192:Skin Diseases, Bacterial / Q000150:complications* / Q000473:pathology; D014057:Tomography, X-Ray Computed