title: Comparison of two techniques of patient-controlled sedation with midazolam.
abstract: OBJECTIVE
  To compare patient-controlled sedation with 1-mg increments of midazolam at 1-min intervals with 0.1-mg increments of midazolam without a lock-out interval.
  
  
  METHODS
  Randomized cross over study.
  
  
  METHODS
  32 patients aged 17-35 years having third molars removed.
  
  
  RESULTS
  Doses of midazolam obtained, degree of sedation and operating conditions were similar in the two groups. The demands far exceeded the increments actually received by patients obtaining 0.1-mg increments. Some were extremely sedated with both techniques.
  
  
  CONCLUSIONS
  In this age group, there were no significant advantages or disadvantages of one technique over the other. Patients obtained the degree of sedation they required to undergo the operation by pressing the button independently of the dose or incremental interval. So-called 'true' patient-controlled sedation is a misnomer. The cut-off interval proved to be an extremely important safety feature.
authors.affiliation: Faculty of Dentistry, University of Hong Kong, Hong Kong, PR China.
authors.forename: M R
authors.initials: MR
authors.lastname: Rodrigo
authors.forename: S C
authors.initials: SC
authors.lastname: Fung
mesh_terms: D000293:Adolescent; D000328:Adult; D016058:Analgesia, Patient-Controlled; D000766:Anesthesia, Dental / Q000379:methods*; D016292:Procedural Sedation / Q000379:methods; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D008964:Molar, Third / Q000601:surgery*; D017060:Patient Satisfaction; D014081:Tooth Extraction
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam