Treatment of dementia-associated agitation with gabapentin.
The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral management of patients with dementia.
Roane
D M
DM
Department of Psychiatry and the Neurobehavior and Alzheimer's Disease Center, Beth Israel Medical Center, New York, NY 10003, USA.
Feinberg
T E
TE
Meckler
L
L
Miner
C R
CR
Scicutella
A
A
Rosenthal
R N
RN
D000085:Acetates / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy*; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D015161:Dementia, Multi-Infarct / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D009460:Neurologic Examination / Q000187:drug effects; D011595:Psychomotor Agitation / Q000175:diagnosis / Q000188:drug therapy*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin