title: Bilateral blindness as the initial presentation of lymphoma of the sphenoid sinus.
abstract: OBJECTIVE
  To report a patient with large-cell lymphoma of the sphenoid sinus presenting with bilateral blindness and no other signs or symptoms.
  
  
  METHODS
  Case report. A previously healthy 5-year-old boy complained of sudden vision loss without other systemic complaints.
  
  
  RESULTS
  Ophthalmologic examination revealed no light perception bilaterally. The pupils of the patient were fixed at 8 mm without reaction to the brightest light stimulus. Systemic examination was unremarkable, and neuroimaging revealed a large sphenoid tumor extending intracranially. Biopsy of the tumor proved to be large-cell lymphoma.
  
  
  CONCLUSIONS
  Large-cell lymphoma affecting children may present initially with blindness, without other systemic symptoms.
authors.affiliation: Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Florida, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Roth
authors.forename: R M
authors.initials: RM
authors.lastname: Siatkowski
mesh_terms: D001766:Blindness / Q000175:diagnosis* / Q000209:etiology; D002675:Child, Preschool; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D008297:Male; D010255:Paranasal Sinus Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000532:radiotherapy; D013101:Sphenoid Sinus / Q000473:pathology* / Q000528:radiation effects; D014057:Tomography, X-Ray Computed