title: Directed evolution of light-activated drugs.
abstract: Photodynamic therapy is a new technology that uses light-activated molecules to target drug action to diseased areas while sparing healthy tissue. Unfortunately, the present arsenal of photosensitive molecules is limited in both number and scope. We hypothesize that new photosensitive molecules could be developed using directed molecules evolution. This paper outlines a possible selection mechanism to evolve molecules activated by a desired wavelength of light.
authors.affiliation: Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, Montreal, Quebec, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Hall
mesh_terms: D019020:Directed Molecular Evolution; D006801:Humans; D008027:Light; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000528:radiation effects / Q000627:therapeutic use
chemical_list: D017319:Photosensitizing Agents