title: A retrospective analysis of Hickman line-associated complications in patients with solid tumours undergoing infusional chemotherapy.
abstract: We present a retrospective analysis of Hickman line use and associated complications in patients with solid tumours undergoing treatment with infusional chemotherapy. One hundred and ten lines were inserted in 94 patients (55 females and 39 males, median age 51), of whom 107 were placed under radiological screening, the remainder by a surgical approach. Catheters were in situ for a total of 9670 days (median 101 days, range 1-278). Fifty-five complications occurred during the lifespan of 39 catheters (35.5%), giving an overall complication rate of 4.03/1000 catheter days. Early complications included pneumothorax (4%), arterial puncture (1%) and failure of placement (1%). Late complications included sepsis (superficial and systemic) (24.5%), venous thrombosis (9%), line displacement (10%) and catheter blockage (1%). Fifteen episodes of systemic sepsis occurred in 12 patients, giving an overall sepsis rate of 1.55/1000 catheter days, while complications requiring catheter removal occurred in 20 cases (18% of insertions, 2.07/1000 catheter days). We conclude that the use of Hickman catheters as a means of long-term venous access in infusional chemotherapy patients is generally safe, but is associated with significant morbidity.
authors.affiliation: CRC Department of Medical Oncology Beatson Oncology Centre, Western Infirmary, Glasgow, UK. vjonlq@udcf.gla.ac.uk
authors.forename: V J
authors.initials: VJ
authors.lastname: O'Neill
authors.forename: T R
authors.initials: TR
authors.lastname: Jeffrey Evans
authors.forename: J
authors.initials: J
authors.lastname: Preston
authors.forename: J
authors.initials: J
authors.lastname: Moss
authors.forename: S B
authors.initials: SB
authors.lastname: Kaye
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents