title: Fibrin glue reduces the severity of intra-abdominal adhesions in a rat model.
abstract: BACKGROUND
  The purpose of this study was to determine whether fibrin glue inhibits intra-abdominal adhesions.
  
  
  METHODS
  Twenty rats underwent midline laparotomy. To maximize adhesions, bilateral peritoneal muscular defects were created and covered with polypropylene mesh sewn with a braided suture. The bowel was abraded with dry gauze. Rats were randomized to either fibrin glue (FG) sprayed over the mesh or to control (no further treatment) groups. At 1 week, the adhesion density (graded 0 to 3), the percentage of the patch covered by adhesion (0% to 100%), and adhesion type were recorded.
  
  
  RESULTS
  The mean adhesion density was 1.45+/-0.33 for FG versus 2.8+/-0.11 for controls (P = 0.001). The mean percentage of adhesions was 36+/-9.9 for the FG group and 94+/-3.7 for controls (P = 0.0002). Bowel or solid organs were adherent to the patch in 6 of 20 (30%) in the FG group versus 12 of 20 (70%) in controls (P = 0.057).
  
  
  CONCLUSIONS
  Topical fibrin glue reduces the density and severity of intra-abdominal adhesions in a rat model.
authors.affiliation: Department of Surgery, Harbor-UCLA Medical Center, Torrance, California 90509, USA.
authors.forename: C
authors.initials: C
authors.lastname: de Virgilio
authors.forename: M
authors.initials: M
authors.lastname: Elbassir
authors.forename: A
authors.initials: A
authors.lastname: Hidalgo
authors.forename: B
authors.initials: B
authors.lastname: Schaber
authors.forename: S
authors.initials: S
authors.lastname: French
authors.forename: S
authors.initials: S
authors.lastname: Amin
authors.forename: B E
authors.initials: BE
authors.lastname: Stabile
mesh_terms: D000818:Animals; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D007813:Laparotomy; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000494:pharmacology*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives