Morphometric analysis of the developing rat brain.
In 2 studies, a method of linear morphometry was applied to regulatory developmental neurotoxicity studies in the rat. The first study involved the development of the brain during postnatal days (PNDs) 7-63, and the second involved the effects of 8 mg/kg i.p. trimethyltin chloride (TMT) to rats at PND 8, with morphometry performed at PNDs 12 and 24. The results of the TMT linear morphometry were compared with those from stereologic counting of neurons in the cerebral cortex, piriform cortex, and hippocampus. Stereology produces more meaningful data than simple linear morphometry for use in the regulatory assessment of the developmental neurotoxicity potential of compounds.
Duffell
S J
SJ
AstraZeneca Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom. stephen.duffell@ctl.astrazeneca.com
Soames
A R
AR
Gunby
S
S
D000375:Aging / Q000502:physiology; D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000187:drug effects / Q000254:growth & development*; D002452:Cell Count / Q000187:drug effects; D005260:Female; D017408:Guidelines as Topic; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology; D016612:Paraffin Embedding; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D014298:Trimethyltin Compounds / Q000633:toxicity
D014298:Trimethyltin Compounds