title: Outbreak of meningococcal disease in western Norway due to a new serogroup C variant of the ET-5 clone: effect of vaccination and selective carriage eradication.
abstract: A new sulphonamide resistant (SR) C: 15:P1.7,16 meningococcal strain, a variant of the ET-5 clone, dominated in an outbreak of 22 cases in western Norway commencing in 1995. The first eight patients were 15-21 years old from the Nordhordland area, initiating a carrier study in the local high schools. Carriage of SR serogroup C meningococci was detected by routine methods and treated with a single dose of ofloxacin 400 mg. Of 20 treated carriers, 14 harboured the outbreak strain C: 15:P1.7,16. Vaccination of 4000 children, adolescents and close contacts of patients was also performed. After the intervention, 14 additional cases of meningococcal disease occurred, 8 due to the outbreak strain. However, incidence rates dropped from 180 to 30 per 100000 per year in the student population, but increased from 0 to 13 in the rest of the population in Nordhordland. Carriage eradication is not generally recommended in Norway. However, tracing and treating meningococcal carriage may have reduced transmission and disease in this outbreak situation.
authors.affiliation: Institute of Medicine, University of Bergen, Norway.
authors.forename: I
authors.initials: I
authors.lastname: Smith
authors.forename: A K
authors.initials: AK
authors.lastname: Lehmann
authors.forename: L
authors.initials: L
authors.lastname: Lie
authors.forename: A
authors.initials: A
authors.lastname: Digranes
authors.forename: D A
authors.initials: DA
authors.lastname: Caugant
authors.forename: E A
authors.initials: EA
authors.lastname: Høiby
authors.forename: L O
authors.initials: LO
authors.lastname: Frøholm
authors.forename: A
authors.initials: A
authors.lastname: Halstensen
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002353:Carrier State; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000517:prevention & control; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000145:classification; D009664:Norway / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D013334:Students; D013449:Sulfonamides / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001428:Bacterial Vaccines; D013449:Sulfonamides