Signaling mechanisms in the antimicrobial host defense of Drosophila.
Drosophila has appeared in recent years as a powerful model to study innate immunity. Several papers published in the past year shed light on the role of the three Rel proteins Dorsal, Dif and Relish in the regulation of antimicrobial peptide expression. In addition, the discovery that a blood serine protease inhibitor is involved in the control of the antifungal response indicates that Toll is activated upon triggering of a proteolytic cascade and does not function as a Drosophila pattern recognition receptor.
Imler
J L
JL
UPR 9022 CNRS, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, 67084, France. JL.Imler@ibmc.u-strasbg.fr
Hoffmann
J A
JA
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D029721:Drosophila Proteins; D005786:Gene Expression Regulation; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D011956:Receptors, Cell Surface; D015398:Signal Transduction; D051193:Toll-Like Receptors
D000890:Anti-Infective Agents; D029721:Drosophila Proteins; D019476:Insect Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors