Nonviral gene therapy: promises and challenges.
The last 10 years have seen substantial progress in the development and application of nonviral vectors in gene therapy. However, many problems remain to be resolved before nonviral gene therapy can become a standard clinical practice. This review highlights the major breakthroughs in this field. The problems and future research directions are also discussed. Gene Therapy (2000) 7, 31-34.
Li
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Center of Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy University of Pittsburgh, W1351 Biomedical Science Tower, Pittsburgh, PA 15261, USA.
Huang
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D002678:Chimera / Q000235:genetics; D004247:DNA / Q000235:genetics; D018014:Gene Transfer Techniques / Q000639:trends; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics*; D006801:Humans; D012313:RNA / Q000235:genetics
D012313:RNA; D004247:DNA