title: The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.
abstract: A new series of potential flavonoidic modulators of P-glycoprotein activity has been prepared. The flavanolignan silybin was first oxidised to dehydrosilybin and then C-alkylated with either prenyl or geranyl bromide. The resulting isoprenoid dehydrosilybins were shown to display high in vitro affinities for direct binding to P-glycoprotein, which ranged them among the best flavonoids ever tested.
authors.affiliation: Laboratoire des Produits Naturels, UPRESA 5013, Université Claude Bernard-Lyon 1, Villeurbanne, France.
authors.forename: M
authors.initials: M
authors.lastname: Maitrejean
authors.forename: G
authors.initials: G
authors.lastname: Comte
authors.forename: D
authors.initials: D
authors.lastname: Barron
authors.forename: K
authors.initials: K
authors.lastname: El Kirat
authors.forename: G
authors.initials: G
authors.lastname: Conseil
authors.forename: A
authors.initials: A
authors.lastname: Di Pietro
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry*; D018432:Drug Resistance, Multiple; D005419:Flavonoids / Q000138:chemical synthesis*; D044948:Flavonols; D009682:Magnetic Resonance Spectroscopy; D020944:Silybum marianum / Q000737:chemistry; D015394:Molecular Structure; D010946:Plants, Medicinal; D011485:Protein Binding; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry; D012838:Silymarin / Q000031:analogs & derivatives*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D005419:Flavonoids; D044948:Flavonols; D012838:Silymarin; D011794:Quercetin; C003377:taxifolin