Postantibiotic effects and bactericidal activities of clarithromycin-14-hydroxy-clarithromycin, versus those of amoxicillin-clavulanate, against anaerobes.
The bactericidal activities and postantibiotic effects (PAE) of clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate against Bacteroides fragilis and Peptostreptococcus anaerobius were determined. A concentration of twice the MIC resulted in bactericidal activity against four of four and three of four organisms at 24 h with clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate, respectively. The PAE of clarithromycin-14-hydroxy-clarithromycin was 1.44 to 3.20 h, compared to the less than 1 h of amoxicillin-clavulanate. Clarithromycin-14-hydroxy-clarithromycin possesses good activity against susceptible anaerobes.
Jung
R
R
Department of Pharmacy Practice, University of Colorado Health Science Center, Denver, Colorado, USA.
Messick
C R
CR
Pendland
S L
SL
Tesoro
E P
EP
Losendahl
K J
KJ
Schriever
C A
CA
Danziger
L H
LH
D019980:Amoxicillin-Potassium Clavulanate Combination / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000254:growth & development; D017291:Clarithromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010462:Peptostreptococcus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; C056228:14-hydroxyclarithromycin; D019980:Amoxicillin-Potassium Clavulanate Combination; D017291:Clarithromycin