[Experimental study of FZBZ decoction enhancing chemotherapy efficacy for mice bearing with tumors].
To study the mechanism of the increasing effect of Fuzheng Baozhen decoction (FZBZD) on chemotherapy. The BALB/C mice with transplanted human lung adenocarcinoma (SPC-A-1), sarcoma (S180) were treated in different groups. Comparing the group treated with chemotherapy (CTX), and the group treated with CTX plus FZBZD, the inhibiting tumor rate was higher (P < 0.01), the cAMP/cGMP ratio was increased by adding cAMP level in cancer tissue (P < 0.05), the level of serum TNF-alpha and MDA was decreased (P < 0.01), the activity of total SOD was improved (P < 0.01), the G0/G1 phase cells enhanced and S phase cells decreased in tumor tissue (P < 0.05). It suggested that FZBZD increased the effect of chemotherapy in different ways.
Li
J
J
Institute of Combined Traditional Chinese and Western Medicine, Hunan Medical University, Changsha.
Li
X
X
Li
J
J
Chen
G
G
Li
X
X
Zhang
X
X
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012510:Sarcoma 180 / Q000188:drug therapy*
D004365:Drugs, Chinese Herbal; D003520:Cyclophosphamide