Small doses of capsaicin given intragastrically inhibit gastric basal acid secretion in healthy human subjects.
Although the direct inhibitory effect of small dose of capsaicin on gastric secretory responses was proved in animal observations, the role of capsaicin-sensitive afferent nerves (CSAN) and the effect of capsaicin applied in small and high doses on gastric secretion in human has not been clarified yet. In this study we investigated the influence of different small doses (100-800 microg) of capsaicin given intragastrically through an orogastric tube on gastric basal secretory responses in 10 healthy human subjects. Gastric basal secretory responses (volume, H+-concentration, H+-output) were measured from the suctions of gastric juice for a 1-h period. It has been found that: a) capsaicin dose-dependently inhibited the volume and H+-output of gastric juice; b) ID50 was found to be about 400 microg for capsaicin on gastric acid secretion; c) the time interval for capsaicin-induced gastric inhibition existed for about 1 h indifferently from the higher dose (800 microg) of capsaicin given after. It has been concluded that the capsaicin (given in small doses) inhibits the gastric basal acid output via stimulation of the inhibition of capsaicin sensitive afferent nerves.
Mózsik
G
G
First Department of Medicine, University Medical School of Pécs, Hungary.
Debreceni
A
A
Abdel-Salam
O M
OM
Szabó
I
I
Figler
M
M
Ludány
A
A
Juricskay
I
I
Szolcsányi
J
J
D000328:Adult; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D002211:Capsaicin / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D006801:Humans; D007441:Intubation, Gastrointestinal; D008297:Male
D002211:Capsaicin