HLA-DR4 allele frequencies on Indian and Mestizo population from Mexico.
Using PCR-SSOP and sequencing, we examined DRB1*04 nucleotide polymorphism in 137 DR4-positive Mexican healthy individuals (46 Mexican Mestizos, 64 Mazatecans, and 27 Nahuas), carrying a total of 147 DR4 haplotypes. Eleven different DRB1*04 alleles were detected in Mexican Mestizo population, whereas, in the two Indian groups a restricted polymorphism was observed (5 variants in Mazatecans and 4 in Nahuas). DRB1*0407 was the most frequent allele (gf = 0.106 in Mexican Mestizos, gf = 0.281 in Mazatecans, and gf = 0.189 in Nahuas). In spite of the restriction in polymorphism, there were differences on DRB1*04 alleles found in Mexicans mainly between Mazatecan and Nahua populations. DRB1*0403 was characteristic allele in Nahua ethnic group, whereas, 0404 and 0411 were predominant alleles in Mazatecans. This data corroborates the restricted polymorphism of DRB1*04 alleles in American populations. In spite of the restriction in this polymorphism, differences in frequencies of DRB1*04 alleles could help distinguish each population.
Vargas-Alarcón
G
G
Cellular Biology Section, Physiology Department, Instituto Nacional de Cardiología Ignacio Chávez, México. guargas63@yahoo.com
Gamboa
R
R
Zuñiga
J
J
Hernández-Pacheco
G
G
Ramos-Kuri
M
M
Castillo
E
E
Gómez-Casado
E
E
Martínez-Laso
J
J
Arnaiz-Villena
A
A
Granados
J
J
D005787:Gene Frequency; D015804:HLA-DR4 Antigen / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D044465:White People / Q000235:genetics*
D015804:HLA-DR4 Antigen