title: Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog.
abstract: Spatial learning and memory in young and old dogs was studied in a series of experiments using a delayed non-matching to position (DNMP) paradigm. Past research from our laboratory has suggested that aged dogs perform more poorly on a version of the DNMP task compared to young dogs [Head et al., Spatial learning and memory as a function of age in the dog, Behav. Neurosci. 1995;109(5):851-585]. We have now extended these findings by testing a large number of dogs on three different variations of the DNMP paradigm to evaluate different aspects of spatial learning and memory. Our results indicate that: (1) aged dogs show impaired spatial learning compared to young dogs, (2) aged dogs display spatial working memory deficits compared to young dogs, (3) young dogs have a greater maximum working spatial memory capacity than old dogs and (4) we can use the DNMP paradigm to cognitively categorize different subsets of aged dogs. These data indicate that the DNMP paradigm can serve as a valuable tool to evaluate age-dependent cognitive dysfunction in the canine.
authors.affiliation: Department of Pharmacology, University of Toronto, Ont., Canada.
authors.forename: B
authors.initials: B
authors.lastname: Adams
authors.forename: A
authors.initials: A
authors.lastname: Chan
authors.forename: H
authors.initials: H
authors.lastname: Callahan
authors.forename: C
authors.initials: C
authors.lastname: Siwak
authors.forename: D
authors.initials: D
authors.lastname: Tapp
authors.forename: C
authors.initials: C
authors.lastname: Ikeda-Douglas
authors.forename: P
authors.initials: P
authors.lastname: Atkinson
authors.forename: E
authors.initials: E
authors.lastname: Head
authors.forename: C W
authors.initials: CW
authors.lastname: Cotman
authors.forename: N W
authors.initials: NW
authors.lastname: Milgram
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology*; D000818:Animals; D004285:Dogs / Q000502:physiology*; D005260:Female; D008297:Male; D008568:Memory / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology*