Altered cAMP-dependent protein kinase A in platelets of patients with obsessive-compulsive disorder.
OBJECTIVE
The purpose of this study was to assess cAMP-dependent protein kinase A in patients with obsessive-compulsive disorder (OCD).


METHODS
The levels and the activity of protein kinase A were evaluated in whole platelets obtained from 12 unmedicated patients with OCD and 15 healthy comparison subjects.


RESULTS
The immunolabeling of protein kinase A regulatory subunits type I and II were significantly greater but that of the catalytic subunit significantly lower in patients with OCD than in healthy subjects. The cAMP-stimulated activity in patients with OCD was significantly lower than that in healthy subjects.


CONCLUSIONS
These data suggest a possible role of protein kinase A in the pathophysiology of OCD.
Perez
J
J
Istituto Scientifico H. San Raffaele, Department of Neuropsychiatric Sciences, Milan, Italy. perez.jorge@hsr.it
Tardito
D
D
Ravizza
L
L
Racagni
G
G
Mori
S
S
Maina
G
G
D000199:Actins / Q000097:blood; D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000097:blood* / Q000502:physiology; D006801:Humans; D015151:Immunoblotting; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000097:blood / Q000201:enzymology* / Q000503:physiopathology
D000199:Actins; D017868:Cyclic AMP-Dependent Protein Kinases