Flutamide suppressed prostate hypertrophy in rats and mice.
OBJECTIVE
To study the suppressive effect of flutamide (Flu) on benign prostate hypertrophy.


METHODS
The effect of Flu 10, 25, and 50 mg.kg-1 i.g. on the prostate was tested in orchiectomized rats with s.c. testosterone daily for 30 d and in mice implanted with homologous strain fetal mouse urogenital sinus for 14 d.


RESULTS
1) Flu dose-dependently suppressed the weight and volume of each lobe of the prostate to about 10%-50% of control. Also, the acini and height of epithelial cells atrophied. The effect was more powerful than that of estradiol (Est). 2) The weight and volume of the mouse prostate diminished in Flu-treated groups, but the dose-response relationship was seen only in volume. In this model, Est was better than Flu.


CONCLUSIONS
Flu possesses the suppressive action on benign prostate hypertrophy.
Zhang
Y Y
YY
Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China.
Li
P F
PF
Chen
B L
BL
Li
D
D
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005485:Flutamide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000726:Androgen Antagonists; D004958:Estradiol; D005485:Flutamide