Viral-encoded cyclins.
D-type cyclin homologs have been found in the genomes of herpesviruses associated with neoplasias. They appear to exploit features of G(1) cyclins but extend their properties to allow for deregulation of the cell cycle. Advances in the study of the molecular basis for these novel features as well as the potential role of viral cyclins in tumorigenesis are addressed.
Laman
H
H
Molecular Oncology Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK.
Mann
D J
DJ
Jones
N C
NC
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D050759:Cyclin-Dependent Kinase Inhibitor p21; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D016213:Cyclins / Q000235:genetics* / Q000378:metabolism; D006564:Herpesviridae / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000821:virology; D009857:Oncogenes; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D014764:Viral Proteins; D018844:Cyclin-Dependent Kinases