title: Changes in food intake and food selection in rats after 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.
abstract: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on food selection were studied in TCDD-resistant Han/Wistar and TCDD-sensitive Long-Evans rats and their crosses. The rats were offered a selection diet consisting of chocolate, cheese, and chow, and TCDD was given at the same time or 4 or 16 days later. TCDD persistently reduced the chocolate intake. When the selection diet was started at the time of or less than 11 h after TCDD exposure, TCDD almost completely prevented the intake of chocolate and also cheese in all strains already on the first day, while controls started to consume large amounts of both foods. This may be due to conditioned taste aversion. The effect on food selection with familiar foods seemed to reduce fat intake, while protein and carbohydrate intakes were more variable. There were no major strain differences in the chocolate intake inhibition despite a 1000-fold sensitivity difference in TCDD lethality.
authors.affiliation: National Public Health Institute, Department of Environmental Medicine, P.O. Box 95, FIN70701, Kuopio, Finland.
authors.forename: J T
authors.initials: JT
authors.lastname: Tuomisto
authors.forename: M
authors.initials: M
authors.lastname: Viluksela
authors.forename: R
authors.initials: R
authors.lastname: Pohjanvirta
authors.forename: J
authors.initials: J
authors.lastname: Tuomisto
mesh_terms: D000818:Animals; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D000072317:Polychlorinated Dibenzodioxins