[Effect of tetrandrine on pulmonary vascular morphology in rats with hypoxia pulmonary hypertension].
To investigate the effect of Tetrandrine on pulmonary vascular morphology in rats with hypoxia pulmonary hypertension. We established the model of hypoxia pulmonary hypertension and observed the small pulmonary arterial morphologic changes under light microscope and electron microscope after the rats were treated with Tetrandrine; also, we made morphometric analysis. The results showed that the small pulmonary arteria in rats with hypoxia pulmonary hypertension was thinner than normal ones and had proliferation of smooth muscular cells. Morphometry displayed that the external diameter became smaller and that the ratio of vascular wall thickness to external diameter (M/T%) and the ratio of vascular wall area to total area (MA%) increased. The pathologic change significantly decreased after the rats were treated with Tetrandrine, indicating that Tetrandrine inhibited hypoxia-induced thickening and muscularization of small pulmonary arteria by inhibiting the proliferation of collagenous fibers so that narrowing of small pulmonary arteria was significantly slackened and pulmonary hypertension was alleviated. Therefore, we conclude that tetrandrine may partly prevent the development of pulmonary hypertension.
Li
W
W
Department of Internal Medicine, First Affiliated Hospital, Chengdu.
Chen
W
W
Zhang
S
S
Lei
S
S
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001160:Arterioles / Q000473:pathology / Q000648:ultrastructure; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000473:pathology*; D000860:Hypoxia / Q000150:complications*; D007091:Image Processing, Computer-Assisted; D008297:Male; D011651:Pulmonary Artery / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats
D000470:Alkaloids; D044182:Benzylisoquinolines; D002121:Calcium Channel Blockers; C009438:tetrandrine