Severe hypoglycaemia caused by raised insulin-like growth factor II in disseminated breast cancer.
A 60 year old woman with disseminated ductal carcinoma of the breast developed non-islet cell tumour induced hypoglycaemia (NICTH). The concentrations of the two insulin-like growth factors, IGF-I and IGF-II, were < 2 nmol/l and 94.1 nmol/l, respectively. The IGF-II to IGF-I ratio was > 47 (normal < 10). Insulin (< 3 mu/l) and C peptide (< 100 pmol/l) were both undetectable.
Bessell
E M
EM
Department of Clinical Oncology, Nottingham City Hospital, UK.
Selby
C
C
Ellis
I O
IO
D000231:Adenocarcinoma, Papillary / Q000097:blood* / Q000473:pathology; D001859:Bone Neoplasms / Q000097:blood / Q000473:pathology / Q000556:secondary; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000473:pathology; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007335:Insulin-Like Growth Factor II / Q000032:analysis*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000097:blood / Q000473:pathology / Q000556:secondary
D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II