Enantiomer separation of pharmaceuticals by capillary gas chromatography with novel chiral stationary phases.
New chiral stationary phases of polydimethylsiloxane anchored with (S)-(-)-t-leucine derivatives were provided for use in enantiomer separation of pharmaceuticals by capillary gas chromatography. Fifteen pharmaceuticals were separated into their enantiomeric pairs by converting them into pentafluoropropionyl and heptafluorobutyryl derivatives. The separation factor and resolution obtained from the new phases were superior to those from the conventional Chirasil-Val capillary column.
Abe
I
I
Department of Applied Chemistry, College of Engineering, Osaka Prefecture University, Gakuen-cho, Sakai, Osaka 599-8531 Japan.
Terada
K
K
Nakahara
T
T
D002849:Chromatography, Gas / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations