title: [Comparative study of tetracycline-estrone and estrone effects on bone histomorphometric parameters in ovariectomized rats].
abstract: OBJECTIVE
  To compare the effects of tetracycline-estrone (TE) and estrone (E) on bone histomorphometric parameters of femoral distal diaphysis in ovariectomized (OVX) rats.
  
  
  METHODS
  Twenty female rats were randomly allocated into four groups, 5 rats in each: tetracycline-estrone (TE), estrone (E), OVX and sham operation (S). The OVX rats were used as a model for osteoporosis. After being fed with TE or E for 13 weeks, all rats were sacrificed. The effects of TE and E on bone microarchitecture and dynamics were studied by bone histomorphometry.
  
  
  RESULTS
  The histomorphometric data showed that the connectivity of trabecular bone in TE and E groups was significantly improved in comparision with that in S group (P < 0.05). The dynamic data indicated that in TE and E group, the tetracycline labelled and osteoid surfaces were remarkably increased in comparision with those in OVX group, especially the data in TE group were significantly higher than those in E group and other two groups (P < 0.05).
  
  
  CONCLUSIONS
  The connectivity of trabecular bone could be significantly improved by both TE and E. The activation frequency seemed to be higher in TE group than that in E group.
authors.affiliation: General Hospital, Tianjin Medical University.
authors.forename: B
authors.initials: B
authors.lastname: Lu
authors.forename: M
authors.initials: M
authors.lastname: Qiu
authors.forename: H
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000818:Animals; D015519:Bone Density; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D005269:Femur; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013752:Tetracycline
chemical_list: D004970:Estrone; D013752:Tetracycline