title: [Detection of the level of serum antigen recognized by McAbGB2 in breast cancer].
abstract: This study sought to verify the levels of serum antigen recognized by McAbGB2 (abbr. serum McAbGB2 antigen) in patients with breast cancer. We adopted the ELISA method and used McAbGB2 to detect the level of serum McAbGB2 antigen in 50 normal persons and 60 patients with breast cancer. The results showed that the level of serum McAbGB2 antigen of 17 preoperative patients with breast cancer was significantly different from that of the normal persons (P < 0.001); the rate of agreement on positivity for the 17 preoperative patients with breast cancer was 88.2% (15/17); the levels of serum McAbGB2 antigen in 8 patients among the 17 preoperative patients with breast cancer decreased from 57.5 +/- 51.3 u/ml (preoperation) to 20.6 +/- 4.98 u/ml (postoperation; the levels of serum McAbGB2 antigen in the other 43 operated patients with breast cancer almost remained normal during post-operative chemotherapy. These suggest that serum McAbGB2 antigen is a marker for breast cancer and can be used for serological diagnosis, treatment and prognosis inspection.
authors.affiliation: Department of Biochemistry, School of Basic Medicine, Chengdu.
authors.forename: G
authors.initials: G
authors.lastname: Cai
authors.forename: L
authors.initials: L
authors.lastname: Wei
authors.forename: A
authors.initials: A
authors.lastname: Fan
mesh_terms: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000097:blood* / Q000276:immunology; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000276:immunology*; D005260:Female; D006801:Humans
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor