title: Synthesis, characterization, and platelet adhesion studies of novel aliphatic polyurethaneurea anionomers based on polydimethylsiloxane-polytetramethylene oxide soft segments.
abstract: Two novel aliphatic polyurethaneurea anionomers were synthesized based on polydimethylsiloxane (PDMS)-polytetramethylene oxide (PTMO) soft segments. The hard segments consisted of either 4,4'-methylene dicyclohexyl diisocyanate (H12MDI), sulfonic acid-containing diol and 1,4-butandiol (BD) or H12MDI, carboxylic acid-containing diol and BD. The nonionic counterpart chain extended with BD was prepared. In addition, the base nonionic polyurethaneurea containing a pure PDMS soft segment, which is denote H-D-BD, was also studied for comparison. The effects of soft segment type and ion incorporation on the physical properties, surface properties, and plateled adhesion are discussed. The ionic polyurethaneureas exhibited poor phase separation, a smaller fraction of PTMO present at the surface, and a smaller contact angle. On the other hand, it also showed a larger fraction of PDMS present at the surface and a higher water absorption value than its nonionic counterpart. H-D-BD had more phase-separated structure, a larger fraction of PDMS present at the surface, and larger contact angle but lower water absorption value than the PTMO-containing polyurethaneureas. The in vitro platelet adhesion experiments indicated that the ionic groups, especially for carboxylate, and surface enrichment PDMS soft segment could effectively inhibit platelet adhesion.
authors.affiliation: Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan, ROC.
authors.forename: K Y
authors.initials: KY
authors.lastname: Chen
authors.forename: J F
authors.initials: JF
authors.lastname: Kuo
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000838:Anions / Q000494:pharmacology; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002152:Calorimetry, Differential Scanning; D004129:Dimethylpolysiloxanes / Q000138:chemical synthesis*; D004577:Electron Probe Microanalysis; D006018:Glycols / Q000138:chemical synthesis*; D006801:Humans; D008970:Molecular Weight; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011140:Polyurethanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012828:Silicones / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D013499:Surface Properties; D013718:Tensile Strength; D014906:Wetting Agents / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000838:Anions; D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D006018:Glycols; D011140:Polyurethanes; D012828:Silicones; D014906:Wetting Agents; C047554:polytetramethylene glycol; C013830:baysilon; C044690:polyetherurethane urea