Mitigation of arthritis by high-dose administration of a COX-2 inhibitor in the collagen-induced arthritis model in the mouse.
Obukowicz
M G
MG
G.D. Searle, St. Louis, MO, USA.
Ornberg
R L
RL
D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003094:Collagen / Q000276:immunology; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage* / Q000097:blood; D013449:Sulfonamides / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D011720:Pyrazoles; C405508:SC 046; D013449:Sulfonamides; D003094:Collagen; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases