Phospholipase A(2) enzymes: structural diversity in lipid messenger metabolism.
The phospholipases A(2) (PLA(2)s) are a large family of enzymes with varied lipidic products which are involved in numerous signal transduction pathways. The structural and functional characterization of several PLA(2)s have revealed the various mechanisms used by these enzymes to ingeniously manipulate the phospholipidic metabolic machinery.
Dessen
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European Molecular Biology Laboratory, Grenoble, 38000, France. dessen@embl-grenoble.fr.
D002118:Calcium / Q000378:metabolism; D020134:Catalytic Domain; D003600:Cytosol / Q000201:enzymology; D004789:Enzyme Activation; D050356:Lipid Metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D010741:Phospholipases A / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
D008565:Membrane Proteins; D010741:Phospholipases A; D002118:Calcium