Inhibition of chymase reduces vascular proliferation in dog grafted veins.
We investigated the effect of a chymase inhibitor Suc-Val-Pro-Phe(P)(OPh)(2) on the proliferation of the grafted vein in dog. By 28 days after the operation, the mean intimal area of the grafted vein in the placebo group was 3.24+/-0.32 mm(2). The intimal area of the grafted vein in the chymase inhibitor-treated group was reduced to 63.9%. In the placebo group, the activities of chymase and angiotensin-converting enzyme in grafted vein were significantly increased 15- and 2-fold, respectively. In the chymase inhibitor-treated group, chymase activity in the grafted veins was decreased significantly. These findings suggest that inhibition of chymase appears useful for preventing vascular proliferation.
Takai
S
S
Department of Pharmacology, Osaka Medical College, Takatsuki City, Osaka, Japan.
Yuda
A
A
Jin
D
D
Nishimoto
M
M
Sakagichi
M
M
Sasaki
S
S
Miyazaki
M
M
D000818:Animals; D053818:Chymases; D004285:Dogs; D009842:Oligopeptides / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D013997:Time Factors; D017539:Tunica Intima / Q000187:drug effects / Q000254:growth & development / Q000473:pathology; D014661:Vasoconstriction / Q000187:drug effects; D014680:Veins / Q000187:drug effects / Q000473:pathology / Q000637:transplantation*
D009842:Oligopeptides; D015842:Serine Proteinase Inhibitors; C102024:succinyl-valyl-prolyl-phenylalanyl-diphenylphosphonate; D012697:Serine Endopeptidases; D053818:Chymases