[Substituted cyclodextrins as chelating reagents for ethers, thioethers and yperite].
The complexation of mustard gas Cl(CH(2))(2)S(CH(2))(2) Cl, HD, yperite) and of ethers and thioethers derivatives by cyclodextrins: natural alpha-cyclodextrin (ACD) and substituted B-cyclodextrins was studied by NMR. A 1/1 stoechiometry was found in all cases, while affinity constants were found relatively weak (from 5 M(-1) to 100 M(-1)). However, these results show that chelation of HD by cyclodextrins can be reasonably expected, especially if chemical modifications provide stronger affinity constants.
Debouzy
J C
JC
Unité de Biophysique Cellulaire et Moléculaire CRSSA, 24, avenue des Maquis de Grésivandan, F 38702 La Tronche Cedex.
Dabouis
V
V
Fauvelle
F
F
Steinbräkner
S
S
Gentilhomme
E
E
D000931:Antidotes / Q000737:chemistry*; D002240:Carbohydrate Sequence; D002614:Chelating Agents / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D008969:Molecular Sequence Data; D009151:Mustard Gas / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013440:Sulfides / Q000737:chemistry*
D000931:Antidotes; D002614:Chelating Agents; D003505:Cyclodextrins; D004987:Ethers; D013440:Sulfides; D009151:Mustard Gas