Inhibitory effect of TMK-688 on late asthmatic responses as well as T-cell and eosinophilic infiltration in guinea pigs with asthmatic reactions.
The effects of an oral anti-allergic agent, TMK-688, which inhibits 5-lipoxygenase, at doses of 3.2 and 10 mg/kg were studied in guinea pigs with dual-phase asthmatic response. We previously observed that pretreatment with TMK-688 inhibited the late asthmatic response (LAR) induced by ovalbumin inhalation exposure. The present study focused on the effect of TMK-688 on infiltration by T-cells and eosinophils. TMK-688 inhibited both T-cell and eosinophilic infiltration. These findings suggest that TMK-688 is effective in inhibiting infiltration of T-cells and eosinophilic chemotaxis, and thereby suppresses LAR.
Tohda
Y
Y
Fourth Department of Internal Medicine, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama-shi, Osaka 589-0014, Japan.
Muraki
M
M
Kawai
A
A
Iwanaga
T
T
Kubo
H
H
Fukuoka
M
M
Nakajima
S
S
D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001094:Arachidonate 5-Lipoxygenase / Q000502:physiology; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology; D001980:Bronchi / Q000473:pathology; D004804:Eosinophils / Q000187:drug effects*; D006168:Guinea Pigs; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010880:Piperidines / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects*
D018927:Anti-Asthmatic Agents; D016859:Lipoxygenase Inhibitors; D010880:Piperidines; C087493:TMK 688; D010047:Ovalbumin; D001094:Arachidonate 5-Lipoxygenase