title: Intradialytic parenteral nutrition in malnourished hemodialysis patients. Review of the literature.
abstract: Malnutrition is a frequent problem of patients on intermittent hemodialysis and is associated with increased morbidity and mortality. Intradialytic parenteral nutrition (IDPN), i.e. intravenous supplementation of mixtures of glucose, amino acids and/or lipids during the hemodialysis session, is one of the therapeutic measures that are applied to correct this malnutrition. To our knowledge only few long-term clinical studies have been undertaken, evaluating the effect of intravenous calorie administration in hemodialysis. Most studies were carried out over a relatively short observation period in small study populations; in several of these studies, no measures were taken to prevent losses of nutrients in the dialysate; adequate control groups are often missing. The authors review the current available literature and conclude that IDPN might have a significant beneficial effect on the nutritional status in malnourished hemodialysis populations.
authors.affiliation: Division of Internal Medicine, Nephrology Department, University Hospital, Gent, Belgium.
authors.forename: A K
authors.initials: AK
authors.lastname: Mortelmans
authors.forename: R
authors.initials: R
authors.lastname: Vanholder
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D002149:Energy Intake; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D008055:Lipids / Q000008:administration & dosage; D009748:Nutrition Disorders / Q000209:etiology / Q000628:therapy*; D010288:Parenteral Nutrition; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D000596:Amino Acids; D008055:Lipids; D005947:Glucose