Funalenone, a novel collagenase inhibitor produced by Aspergillus niger.
Funalenone, a phenalene compound that inhibits type I collagenase (MMP-1), was isolated from mycelium of Aspergillus niger FO-5904 by solvent extaction, ODS column chromatography, Sephadex LH-20 column chromatography and reversed phase HPLC. Funalenone inhibited 50% of type I collagenase activity at a concentration of 170 microM, but inhibited 18.3% and 38.7% against 72 kDa and 92 kDa type IV collagenase, respectively, at a concentration of 400 microM.
Inokoshi
J
J
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Shiomi
K
K
Masuma
R
R
Tanaka
H
H
Yamada
H
H
Omura
S
S
D001234:Aspergillus niger / Q000145:classification / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D007659:Ketones; D061965:Matrix Metalloproteinase Inhibitors; D011083:Polycyclic Compounds; D011480:Protease Inhibitors; C405054:funalenone