title: Relative importance of flow versus pressure in splanchnic perfusion during cardiopulmonary bypass in rabbits.
abstract: BACKGROUND
  Decreased gastrointestinal perfusion has been reported during cardiopulmonary bypass (CPB). Conflicting results have been published concerning thresholds of pressure and flow to avoid splanchnic ischemia during CPB. This study compared splanchnic perfusion during independent and randomized variations of CPB pump flow or arterial pressure.
  
  
  METHODS
  Ten rabbits were studied during mild hypothermic (36 degrees C) nonpulsatile CPB using neonatal oxygenators. Simultaneous measurements of tissue blood flow in four different splanchnic areas (gastric, jejunum, ileum, and liver) were performed by laser Doppler flowmetry (LDF) before CPB (T0) and during a 4-step factorial experimental block design. Pressure and flow were alternatively high or low in random order.
  
  
  RESULTS
  Laser Doppler flowmetry was significantly lower than pre-CPB value but was better preserved (analysis of covariance) in all organs, except liver, when CPB flow was high, whatever the pressure. Splanchnic LDF values in the low- versus high-flow groups expressed as perfusion unit were (mean +/- SD): stomach, 94+/-66 versus 137+/-75; jejunum, 118+/-78 versus 172+/-75; ileum, 95+/-72 versus 146+/-83; and liver, 79+/-72 versus 108+/-118. No significant difference of LDF was observed between the high- and low-pressure groups, whatever the flow, except for liver: stomach, 115+/-64 versus 117+/-83; jejunum, 141+/-80 versus 148+/-83; ileum, 127+/-87 versus 114+/-76; liver, 114+/-88 versus 73+/-70.
  
  
  CONCLUSIONS
  Prevention of splanchnic ischemia during CPB should focus on preservation of high CPB blood flow rather than on high pressure.
authors.affiliation: Departement d'anesthesie Reanimatón, Université Claude Bernard, Lyon, France. bastien@cismsun.univ-lyon1.fr
authors.forename: O
authors.initials: O
authors.lastname: Bastien
authors.forename: V
authors.initials: V
authors.lastname: Piriou
authors.forename: A
authors.initials: A
authors.lastname: Aouifi
authors.forename: C
authors.initials: C
authors.lastname: Flamens
authors.forename: R
authors.initials: R
authors.lastname: Evans
authors.forename: J J
authors.initials: JJ
authors.lastname: Lehot
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001831:Body Temperature / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005260:Female; D007082:Ileum / Q000098:blood supply; D017078:Laser-Doppler Flowmetry; D008297:Male; D010106:Oxygenators; D011817:Rabbits; D012039:Regional Blood Flow / Q000502:physiology; D013152:Splanchnic Circulation / Q000502:physiology*; D013270:Stomach / Q000098:blood supply