title: [High-methylprednisolone treatment in acute cervical spinal cord injury without fracture and dislocation].
abstract: We compared methylprednisolone (MP), surgical decompression and both in acute cervical spinal cord injury without fracture and dislocation. The study involved 32 acute cervical spinal cord injury without fracture and dislocation. MP was given to 8 cases (high-MP group) within 8 hours after injury. 12 cases (surgical group) underwent surgical decompression (anterior or posterior approach) within 48 hours after injury. 12 cases (combined group) were treated with MP within 8 hour of their injury and surgical decompression within 48 hours after injury. Neurological function was assessed using scores according to international standards for neurological and functional classification of spinal cord injury. The results showed that combined group were more effective than high-MP or surgical group, in the complete or incomplete spinal cord injury, and in motor and sensory. The risk of such complication as gastrointestinal bleeding or delayed wound healing is not significant with using high-MP.
authors.affiliation: Department of Orthopedic, Beijing Army General Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Sun
authors.forename: S
authors.initials: S
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Huang
mesh_terms: D000368:Aged; D002574:Cervical Vertebrae / Q000293:injuries*; D003131:Combined Modality Therapy; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D013119:Spinal Cord Injuries / Q000209:etiology / Q000628:therapy*
chemical_list: D008054:Lipid Peroxides; D008775:Methylprednisolone