title: Proteinases in bone resorption: obvious and less obvious roles.
abstract: Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.
authors.affiliation: Center for Clinical and Basic Research, 222 Ballerup Byvej, DK-2750, Ballerup, Denmark. jmd@ccbr.dk
authors.forename: J M
authors.initials: JM
authors.lastname: Delaissé
authors.forename: M T
authors.initials: MT
authors.lastname: Engsig
authors.forename: V
authors.initials: V
authors.lastname: Everts
authors.forename: M
authors.initials: M
authors.lastname: del Carmen Ovejero
authors.forename: M
authors.initials: M
authors.lastname: Ferreras
authors.forename: L
authors.initials: L
authors.lastname: Lund
authors.forename: T H
authors.initials: TH
authors.lastname: Vu
authors.forename: Z
authors.initials: Z
authors.lastname: Werb
authors.forename: B
authors.initials: B
authors.lastname: Winding
authors.forename: A
authors.initials: A
authors.lastname: Lochter
authors.forename: M A
authors.initials: MA
authors.lastname: Karsdal
authors.forename: T
authors.initials: T
authors.lastname: Troen
authors.forename: T
authors.initials: T
authors.lastname: Kirkegaard
authors.forename: T
authors.initials: T
authors.lastname: Lenhard
authors.forename: A M
authors.initials: AM
authors.lastname: Heegaard
authors.forename: L
authors.initials: L
authors.lastname: Neff
authors.forename: R
authors.initials: R
authors.lastname: Baron
authors.forename: N T
authors.initials: NT
authors.lastname: Foged
mesh_terms: D001847:Bone Diseases / Q000201:enzymology; D001862:Bone Resorption; D010450:Endopeptidases / Q000378:metabolism*; D005109:Extracellular Matrix / Q000201:enzymology; D006801:Humans
chemical_list: D010450:Endopeptidases