title: Acute histological effects of interstitial hyperthermia on normal rat brain.
abstract: Histological changes in the brains of Fischer rats at different times after interstitial heating with various thermal doses were studied. The brains, subjected to sham-heating, and heating at 39 and 40 degrees C for 30 min showed mild capillary congestion and minimal vacuolation at 4, 24 and 72 h. In the brains heated to 41, 42 and 43 degrees C for 30 min, there was local vascular congestion, petechiae, vacuolation and cellular shrinkage with nuclear pyknosis at 4 h; enhanced congestion and petechiae, acute cellular necrosis, infiltration of polymorphonuclear leukocytes and marked vacuolation at the margin at 24h; total coagulative necrosis of all parenchymal and vascular elements, early liquefaction necrosis and vascular hyperplasia at the margin at 72 h; enhanced vascular hyperplasia at the margin at 120 h and 168 h. The threshold thermal dose for the histopathological damage in the rat brain was heating at 41 degrees C for 30 min.
authors.affiliation: Department of Natural Sciences, Catholic University of Korea, College of Medicine, Seucho-ku, Seoul. lsyng@cmc.cuk.ac.kr
authors.forename: S Y
authors.initials: SY
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Akuta
authors.forename: M
authors.initials: M
authors.lastname: Uda
authors.forename: C W
authors.initials: CW
authors.lastname: Song
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology* / Q000502:physiology; D006979:Hyperthermia, Induced / Q000009:adverse effects; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors