[Kashin-Beck disease in China: osteochondrodysplasia related to nutrition and environment].
Kashin-Beck disease is a endemic juvenile osteochondrodysplasy, whose association with selenium deficiency and/or mycotoxin toxicity has been corroborated by epidemiological studies in China, including Tibet. Iodine deficiency appears to be a new etiological factor. Together with the geographical and epidemiological exploration of the disease, scientific multidisciplinary investigations (clinics, radiological imaging, histology, environmental and molecular biology) should afford to understand the cause of the disease before it disappears as a consequence of the evolution of the Chinese Society, including in Tibet.
Vanderpas
J
J
Neve
J
J
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002681:China; D003677:Deficiency Diseases / Q000150:complications* / Q000188:drug therapy; D019587:Dietary Supplements; D019353:Endemic Diseases; D005506:Food Contamination; D006801:Humans; D007455:Iodine / Q000172:deficiency / Q000627:therapeutic use; D009183:Mycotoxins / Q000009:adverse effects; D009747:Nutritional Physiological Phenomena; D010009:Osteochondrodysplasias / Q000209:etiology* / Q000517:prevention & control; D012643:Selenium / Q000172:deficiency / Q000627:therapeutic use; D018609:Tibet
D009183:Mycotoxins; D007455:Iodine; D012643:Selenium