Finding function through structural genomics.
The recent availability of whole-genome sequences and large numbers of protein-coding regions from high-throughput cDNA analysis has fundamentally changed experimental biology. These efforts have provided huge databases of protein sequences, many of which are of unknown function. Deciphering the functions of these myriad proteins presents a major intellectual challenge.
Shapiro
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L
Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA. shapiro@anguilla.physbio.mssm.edu
Harris
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T
D000595:Amino Acid Sequence; D000818:Animals; D001709:Biotechnology; D019295:Computational Biology; D017124:Conserved Sequence; D016678:Genome; D006801:Humans; D008969:Molecular Sequence Data; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D013329:Structure-Activity Relationship
D011506:Proteins