Cytokinesis without myosin II.
The ability of substrate-anchored Dictyostelium cells to divide without myosin II has opened the possibility of analysing the formation of cleavage furrows in the absence of a contractile ring made of filamentous myosin and actin. Similar possibilities exist in mutants of budding yeast and, less strictly, also in drug-treated mammalian cells. Myosin-II-independent activities in Dictyostelium include the microtubule-induced programming of the cell surface into ruffling areas and regions that are converted into a concave furrow, as well as the translocation of cortexillins and cross-linked membrane proteins towards the cleavage furrow. A centripetal flow of actin filaments followed by their disassembly in the cleavage furrow is proposed to underlie the translocation.
Gerisch
G
G
Max-Planck-Institut für Biochemie, Martinsried, D-82152, Germany. gerisch@biochem.mpg.de
Weber
I
I
D000199:Actins / Q000378:metabolism; D000818:Animals; D002455:Cell Division; D004023:Dictyostelium / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D009218:Myosins / Q000235:genetics / Q000502:physiology*; D015800:Protozoan Proteins
D000199:Actins; D008840:Microfilament Proteins; D015800:Protozoan Proteins; C101109:ctxA protein, Dictyostelium discoideum; C101110:ctxB protein, Dictyostelium discoideum; D009218:Myosins