[Measurement of serum tumor necrosis factor-alpha and interleukin-8 in children with low respiratory tract infection (LRTI) caused by Mycoplasma pneumonia].
OBJECTIVE
To investigate the immunopathological mechanism of LRTI caused by Mycoplasma pneumonia.


METHODS
Serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) from 30 patients with LRTI caused by Mycoplasma pneumonia, were measured with sequence saturated solution competitive radioimmunoassay and sandwich ELISA.


RESULTS
The level of serum TNF-alpha and IL-8 of patients suffering from LRTI caused by Mycoplasma pneumonia were magnificantly higher than that of healthy children. Meanwhile, a positive relationship between serum TNF-alpha and IL-8 was noticed.


CONCLUSIONS
TNF-alpha plays an important role in LRTI caused by Mycoplasma pneumonia, and serves the key factor to the elevation of IL-8.
Che
L
L
Capital Institute of Pediatrics, Beijing.
Lu
J
J
Lu
J
J
D000293:Adolescent; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000097:blood*; D011863:Radioimmunoassay; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha