title: 3'-Beta-ethynyl and 2'-deoxy-3'-beta-ethynyl adenosines: first 3'-beta-branched-adenosines substrates of adenosine deaminase.
abstract: The 3'-C-branched-adenosine and 2'-deoxyadenosine analogues 1-7 were tested as substrate of adenosine deaminase. The 9-(3'-C-ethynyl-beta-D-ribo-pentofuranosyl)adenine 1 and its 2'-deoxy analogue 7 were deaminated by the enzyme while the vinyl and ethyl derivatives 2 and 3 were not. The 9-(3'-C-branched-beta-D-xylo-pentofuranosyl)adenines 4-6 were deaminated by the deaminase.
authors.affiliation: Laboratoire de Chimie Organique Biologique UMR 7509 du CNRS, Université Louis Pasteur, Faculté de Chimie, Strasbourg, France. dtritsch@chimie.u-strasbg.fr
authors.forename: D
authors.initials: D
authors.lastname: Tritsch
authors.forename: P M
authors.initials: PM
authors.lastname: Jung
authors.forename: A
authors.initials: A
authors.lastname: Burger
authors.forename: J F
authors.initials: JF
authors.lastname: Biellmann
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism*; D003839:Deoxyadenosines / Q000378:metabolism; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D003839:Deoxyadenosines; D009705:Nucleosides; D000243:Adenosine Deaminase; D000241:Adenosine