Behaviorally-evoked plasma catecholamine response and 24-hour excretion of urinary catecholamines among cardiac and vascular reactors.
Individuals differ in the cardiac and vascular processes that underlie blood pressure elevations evoked by environmental stimuli; such differences may reflect variability in sympathoadrenal response. We separated 108 healthy, young-adult males into those with predominant elevations in either cardiac output or peripheral resistance when exposed to psychological challenges. We then asked if they differed on other measures of cardiovascular response, concomitant plasma catecholamine reactions or 24-h urinary excretion of catecholamines. Cardiac reactors, relative to vascular reactors, showed reduced cardiac pre-ejection period, a smaller reduction in stroke volume, and elevated plasma epinephrine response and 24-h urinary epinephrine excretion. Vascular reactors, relative to cardiac reactors, responded to mental stress with more elevated diastolic blood pressure, a rise in peripheral resistance and pulse wave velocity, and a greater reduction in stroke volume. Vascular reactors, however, did not show plasma norepinephrine response or 24-h urinary norepinephrine excretion that was greater than cardiac reactors. The results provide partial support for the hypothesis that variability in sympathoadrenal activity contributes to individual differences in cardiac and vascular reactivity, and extend prior observations by demonstrating covariation of behaviorally-elicited cardiac reactivity with the 24-h excretion of epinephrine.
McCaffery
J M
JM
Department of Psychology, University of Pittsburgh, 4015 O'Hara Street, Pittsburgh, PA 15260, USA.
Muldoon
M F
MF
Bachen
E A
EA
Jennings
J R
JR
Manuck
S B
SB
D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000235:genetics / Q000502:physiology*; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology*; D002302:Cardiac Output / Q000235:genetics / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004837:Epinephrine / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014655:Vascular Resistance / Q000235:genetics / Q000502:physiology*
D009638:Norepinephrine; D004837:Epinephrine