title: Mitigation of arthritis by high-dose administration of a COX-2 inhibitor in the collagen-induced arthritis model in the mouse.
authors.affiliation: G.D. Searle, St. Louis, MO, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Obukowicz
authors.forename: R L
authors.initials: RL
authors.lastname: Ornberg
mesh_terms: D000818:Animals; D001168:Arthritis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D003094:Collagen / Q000276:immunology; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage* / Q000097:blood; D004305:Dose-Response Relationship, Drug; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage* / Q000097:blood; D013449:Sulfonamides / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D011720:Pyrazoles; C405508:SC 046; D013449:Sulfonamides; D003094:Collagen; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases