[Influence of idiotypic network regulation on renal transplant].
Pretransplant sera from 68 patients were tested for antiidiotypic antibodies (Ab2) and anti-antiidiotypic antibodies (Ab3) by lyphocytotoxicity inhibitory and potentiating assay. In the first six nomths, 6% of the patients in the Ab2 group had had a rejection episode compared with 21% of the patients in the no antibody (P < 0.01), whereas patients in the Ab3 group had significant rejection episodes (67%) compared with no antibody group (P < 0.01). These results suggest that Ab2 can introduce recipients tolerating the graft in some degree and patients with Ab3 are of high risk of graft rejection.
Ye
Y
Y
Sir Run Run Shaw Hospital, Zhejiang Medical University, Hangzhou.
Yan
L
L
Zhang
X
X
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D005260:Female; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged
D000888:Antibodies, Anti-Idiotypic