title: [Olfactory disorders and general pathology. Analysis and review of the literature].
abstract: BACKGROUND
  Disturbances of the sense of smell have been documented in many general pathologies. The actual etiology of such impairments is often difficult to determine. The aim of the authors is to review the literature on olfactory disorders in general diseases.
  
  
  BACKGROUND
  Acute and chronic liver disorders are frequently associated with hyposmia, which can be improved by vitamin A intake. Renal insufficiency could induce hyposmia according to the severity of the renal disease. Olfactory disorders seem to regress after transplantation but not after dialysis. Patients with AIDS--especially neurological forms--often present with taste and smell impairments. Smell alteration can also be noted in hypothyroidism and pseudohypoparathyroidism. In addition, taste and smell impairments have been described in patients with adrenal insufficiency or Cushing's disease. Subsequent to glucocorticoid therapy, adrenal insufficiency can induce regressive olfactory hypersensitivity. Olfactory impairments in diabetic patients can be associated with diabetic macrovascular manifestations due to ischemic alterations in the olfactory neuroepithelium. Impairment of the sense of smell has been described in many systemic diseases such as Horton's arteritis and Sjögren's syndrome.
  
  
  CONCLUSIONS
  Olfactory disorders should be investigated in patients presenting one of the above-mentioned diseases.
authors.affiliation: Service de médecine interne, université Paris V, hôpital Raymond-Poincaré, Garches, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Norès
authors.forename: B
authors.initials: B
authors.lastname: Biacabe
authors.forename: P
authors.initials: P
authors.lastname: Bonfils
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000473:pathology; D003480:Cushing Syndrome / Q000150:complications / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications* / Q000473:pathology; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D000857:Olfaction Disorders / Q000209:etiology* / Q000473:pathology / Q000628:therapy