title: Cerebral oxygenation is better during mild hypothermic than normothermic cardiopulmonary bypass.
abstract: OBJECTIVE
  Normothermic cardiopulmonary bypass (CPB) has been recently used in cardiac surgery. However, there is a controversy whether there is a difference in incidence of neurological disorder after coronary artery bypass graft (CABG) surgery between normothermic CPB and mild hypothermic CPB. In this study, we assessed the effects of normothermia and mild hypothermia (32 degrees C) during CPB on jugular oxygen saturation (SjvO2).
  
  
  METHODS
  Twenty patients scheduled for elective CABG surgery were divided into two groups. Group 1 (n = 10) underwent normothermic (>35 degrees C) CPB, and Group 2 (n = 10) underwent mild hypothermic (32 degrees C) CPB. Alpha-stat blood gas regulation was applied. After inducing anesthesia, a 4.0 French fibre optic oximetry oxygen saturation catheter was inserted into the right jugular bulb to monitor SjvO2 continuously throughout anesthesia and surgery.
  
  
  RESULTS
  The SjvO2 in the normothermic group was decreased at 20 (41.5+/-2.4%) and 40 min (43.8+/-2.8%) after the onset of CPB compared with control (53.9+/-5.4%, P<0.05). However, there was no change in SjvO2 in the mild hypothermic group during the study. No changes in jugular venous-arterial differences of lactate or creatine phosphokinase isoenzyme BB were observed in two groups during the study.
  
  
  CONCLUSIONS
  Cerebral oxygenation, as assessed by SjvO2 was increased during mild hypothermic CPB than during normothermic CPB.
authors.affiliation: Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Okano
authors.forename: R
authors.initials: R
authors.lastname: Owada
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: Y
authors.initials: Y
authors.lastname: Kadoi
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: F
authors.initials: F
authors.lastname: Goto
mesh_terms: D000368:Aged; D001831:Body Temperature; D001921:Brain / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D006324:Heart Arrest, Induced; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen