title: Pedophilia and temporal lobe disturbances.
abstract: Paraphilias may occur with brain disease, but the nature of this relationship is unclear. The authors report 2 patients with late-life homosexual pedophilia. The first met criteria for frontotemporal dementia; the second had bilateral hippocampal sclerosis. Both were professional men with recent increases in sexual behavior. In both, 18-fluorodeoxyglucose positron emission tomography revealed prominent right temporal lobe hypometabolism. These cases and the literature suggest that bilateral anterior temporal disease affecting right more than left temporal lobe can increase sexual interest. A predisposition to pedophilia may be unmasked by hypersexuality from brain disease. These observations have potential implications for all neurologically based paraphilias.
authors.affiliation: Department of Neurology, University of California at Los Angeles, USA. mmendez@UCLA.edu
authors.forename: M F
authors.initials: MF
authors.lastname: Mendez
authors.forename: T
authors.initials: T
authors.lastname: Chow
authors.forename: J
authors.initials: J
authors.lastname: Ringman
authors.forename: G
authors.initials: G
authors.lastname: Twitchell
authors.forename: C H
authors.initials: CH
authors.lastname: Hinkin
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D010378:Pedophilia / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D012725:Sexual Behavior / Q000502:physiology; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18