Bacterial adaptation to host innate immunity responses.
Several recent reports show that different bacterial components trigger innate and inflammatory responses in host organisms. In parallel, selected bacterial virulence factors have been identified that interfere with corresponding responses. In many cases, this involves interference with host proinflammatory signal transduction pathways, whereas in selected cases bacterial virulence factors interfere with host antibacterial mechanisms. This indicates that bacteria, besides activating cellular responses, also have the capacity to directly interact with branches of the innate defence.
Rhen
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Microbiology and Tumor Biology Center, Karolinska Institute, Swedish Institute for Infectious Disease Control, Stockholm, Solna, 171 77, 171 82, Sweden.
Eriksson
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Pettersson
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D000222:Adaptation, Physiological; D000818:Animals; D001419:Bacteria / Q000276:immunology* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D014774:Virulence