[Effect of the NMDA receptor antagonist on parameters of delayed visual differentiation and rearrangement of the impulse activity of neurons in visual and prefrontal cortices in monkeys].
With the aid of a multichannel leads the unit activity was recorded in the 17th and 8th cortical fields along with registering behavioural data in Rhesus monkeys. Multi-factor variance analysis revealed that the 2-amino-5-phospho-valeric acid (APV) effect involved a significant worsening of the monkeys' behavioural characteristics: duration of the short-term memory shortened (2-4-fold), motor reactions' time increased, and the changes of cognitive characteristics were always followed by significant rearrangements of the unit activity in the above areas. The data obtained suggest that these cognitive dysfunctions are due to a desynchronisation of unit activity in different areas of the cortex including the neuronal assemblies maintaining the short-term memory mechanisms associated with the glutamatergic structures.
Dudkin
K N
KN
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
Kruchinin
V K
VK
Chueva
I V
IV
D000818:Animals; D004193:Discrimination Learning / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008253:Macaca mulatta; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013997:Time Factors; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate