5-Nitroimidazole derivatives as possible antibacterial and antifungal agents.
Some novel 1-[2-[[5-(2-furanyl)-4-substituted 4H-1,2,4-triazol-3-yl[thio[ethyl[-2-methyl-5-nitro-1H-imidazoles (3), 1-[3-[[5-(2-furanyl/2-thienyl)-4-substituted 4H-1,2,4-triazol-3-yl[-thio]-2-hydroxypropyl[-2-methyl-5-nitro-1H- imidazoles (5) and 1-[3-[(N,N-disubstituted thiocarbamoyl)-thio[-2-hydroxypropyl]-2-methyl-5-nitro-1H-imidazoles (7) were synthesized and evaluated for in vitro antibacterial and antifungal activity. Some of 5 were found to be effective against bacteria and fungi (minimum inhibitory concentration (MIC) 7.3-125 micrograms/ml), whereas 7 were found to be effective against fungi (MIC 3-25 micrograms/ml).
Günay
N S
NS
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Capan
G
G
Ulusoy
N
N
Ergenç
N
N
Otük
G
G
Kaya
D
D
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009593:Nitroimidazoles / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009593:Nitroimidazoles; C052587:4-nitroimidazole