Dose findings of dihydroartemisinin in treatment of falciparum malaria.
Forty patients with uncomplicated P. falciparum malaria were respectively treated in an open randomized comparative study of dihydroartemisinin tablets given at total doses of 480 mg over 5 days and 640 mg over 7 days in a drug-resistant malaria endemic area in Hainan, China. The result showed that all patients were clinically cured. In 5-day and 7-day groups, the mean fever clearance times (FCT) were 26.1+/-10.2 and 21.1+/-11.8 hours respectively; the mean parasite clearance times (PCT) were 58.7+/-20.9 and 59.4+/-20.9 hours respectively, which showed no significant difference. 28-day follow-ups were accomplished on 39 and 37 cases respectively in two groups, the recrudescence rates were 20.5% (8/39) in 5-day group, while 2.7% (1/37) in 7-day group with significant difference (chi2=4.19, p<0.05). No clinical drug-related side effect was found in two groups during treatment.
Li
G Q
GQ
Tropical Medicine Institute, Guangzhou University of Traditional Chinese Medicine, PR China.
Wang
X H
XH
Guo
X B
XB
Fu
L C
LC
Jian
H X
HX
Chen
P Q
PQ
Li
G Q
GQ
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins; D002648:Child; D002681:China; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005334:Fever / Q000469:parasitology; D005500:Follow-Up Studies; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology; D008875:Middle Aged; D012717:Sesquiterpenes / Q000008:administration & dosage*; D013997:Time Factors
D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C039060:artenimol