Brain tachykinins and the regulation of salt intake.
The regulation of salt intake is achieved through the coordination of behavioral and physiological responses. Brain neuropeptides, such as the tachykinins, play an important role in orchestrating both of these responses. Intraventricular injections of NK3 receptor agonists, such as senktide, are potent in suppressing salt intake. Experimental results show that intraventricular injections of senktide that suppress salt intake have no effect on the ingestion of other tastes, such as sucrose. The means by which senktide suppresses salt intake was investigated in a series of experiments. Taste reactivity and lick rate analyses suggest that the activation of NK3 receptors reduces salt intake by modulating the oral-stimulating property of salt taste.
Flynn
F W
FW
Department of Psychology, University of Wyoming, Laramie 82071, USA. flynn@uwyo.edu
D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology; D012982:Sodium, Dietary; D013373:Substance P / Q000031:analogs & derivatives / Q000494:pharmacology; D015320:Tachykinins / Q000502:physiology*
D010446:Peptide Fragments; D012982:Sodium, Dietary; D015320:Tachykinins; C054724:senktide; D013373:Substance P