[The effect of growth hormone on wound healing rate in adult burns].
OBJECTIVE
To determine the wound healing effect of rHGH in adult burn patients.


METHODS
16 patients with burn wounds covering over 60% of total body surface (TBSA) were enrolled in this placebo controlled prospective study. They were comparable in nutrient intake, TBSA, and full thickness burn area. rHGH group patients were given rHGH subcutaneously in the dose of 0.3u.Kg-1 at 8 am each morning for 10 days beginning from POD 1. The control group patients were given normal saline as placebo. All the patients received scar excision within 4 days postburn, and the excision wounds were covered with autologous skin pulp grafting. Serum amino acid profile was analyzed at day 1 and day 20 post burn. Healing time of burn wound area and donor site was recorded. Wound healing rate was assessed at day 30 after day.


RESULTS
1. The healing time of autologous skin pulp grafting and donor site, and the length of hospital stay were significantly shorter in GH group patients than control group. 2. The amino acid profile showed no difference between two groups at day 1 and was significantly better in GH group at day 20.


CONCLUSIONS
rHGH could enhance the wound healing rate, improve amino acid profile, and reduce the length of hospital stay of severe burn patients.
Sun
Y
Y
Department of Burn, Beijing Burn Institute, Beijing Jishuitan Hospital.
Zhou
Y
Y
Jiang
Z
Z
D000328:Adult; D002056:Burns / Q000188:drug therapy*; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D016038:Skin Transplantation; D014945:Wound Healing / Q000187:drug effects*
D011994:Recombinant Proteins; D013006:Growth Hormone