Association between diabetic retinopathy and genetic variations in alpha2beta1 integrin, a platelet receptor for collagen.
Platelets might be involved in the pathogenesis of diabetic microangiopathy. Wide interindividual variations in the density of a platelet collagen receptor (alpha2beta1 integrin or glycoprotein Ia/IIa) are reportedly associated with polymorphism(s) in the gene encoding the alpha subunit of the receptor, including a Bgl II polymorphism in intron 7. The aim of the present study was to determine the relationship between the Bgl II polymorphism and the susceptibility to diabetic microangiopathy. A case-control study comparing 227 patients with type II diabetes mellitus (119 with versus 108 without diabetic retinopathy) as well as 169 nondiabetic subjects demonstrated that genotypes with Bgl II (+) allele had a significant increase in the risk for retinopathy. The odds ratio for Bgl II (+/+) to Bgl II (-/-) was 3.41 (95% CI, 1.49-7.78, P =.0036) when analysis was confined to those with a disease duration of diabetes of 10 years or more. The present study suggests that the presence of a Bg II (+) allele is a genetic risk factor for diabetic retinopathy. (Blood. 2000;95:1560-1564)
Matsubara
Y
Y
Department of Medicine, School of Medicine, Keio University, Tokyo, Japan.
Murata
M
M
Maruyama
T
T
Handa
M
M
Yamagata
N
N
Watanabe
G
G
Saruta
T
T
Ikeda
Y
Y
D000483:Alleles; D001426:Bacterial Proteins; D001792:Blood Platelets / Q000378:metabolism*; D016022:Case-Control Studies; D003094:Collagen / Q000378:metabolism*; D015252:Deoxyribonucleases, Type II Site-Specific; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000453:epidemiology / Q000235:genetics; D003930:Diabetic Retinopathy / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016023:Integrins / Q000235:genetics* / Q000502:physiology; D007438:Introns / Q000235:genetics; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics / Q000502:physiology; D015995:Prevalence; D038981:Receptors, Collagen; D012307:Risk Factors
D001426:Bacterial Proteins; D016023:Integrins; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D038981:Receptors, Collagen; D003094:Collagen; C024404:BglII endonuclease; D015252:Deoxyribonucleases, Type II Site-Specific