title: Albendazole treatment for Giardia intestinalis infections in school children.
abstract: A randomized controlled trial, 113 school children with Giardia intestinalis infection were treated with albendazole or tinidazole. Albendazole 400 mg once a day x 3 days and tinidazole 50 mg/kg single dose were given orally to 62 and 51 children, respectively. Parasitological cure was documented when there were > or = 2 times negative stool examination for G. intestinalis at 1-2 weeks after therapy. Thirty-one of 62 (50%) children treated with albendazole and 49 of 51 (96.1%) children treated with tinidazole had parasitological cure (p < 0.001). No major side effects were observed except one case in tinidazole group had severe headache for 30 hours. Albendazole appears to be safe and produced a moderate cure rate for G. intestinalis infection when a 3 day anthelmintic regimen is given.
authors.affiliation: Department of Tropical Pediatrics, Faculty of Tropical Medicine, Bangkok, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Pengsaa
authors.forename: C
authors.initials: C
authors.lastname: Sirivichayakul
authors.forename: C
authors.initials: C
authors.lastname: Pojjaroen-anant
authors.forename: S
authors.initials: S
authors.lastname: Nimnual
authors.forename: P
authors.initials: P
authors.lastname: Wisetsing
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000284:Administration, Oral; D000293:Adolescent; D017677:Age Distribution; D015766:Albendazole / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D002648:Child; D015362:Child Nutrition Disorders / Q000150:complications; D002675:Child, Preschool; D005243:Feces / Q000469:parasitology; D005260:Female; D005873:Giardiasis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D015995:Prevalence; D013785:Thailand / Q000453:epidemiology; D014011:Tinidazole / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000981:Antiprotozoal Agents; D014011:Tinidazole; D015766:Albendazole