The dynamin family of mechanoenzymes: pinching in new places.
The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicle trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to these diverse but related functions are discussed.
McNiven
M A
MA
Dept of Biochemistry and Molecular Biology, The Center for Basic Research in Digestive Diseases, Mayo Foundation, Rochester, MN 55905, USA. mcniven.mark@mayo.edu
Cao
H
H
Pitts
K R
KR
Yoon
Y
Y
D000199:Actins / Q000648:ultrastructure; D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism / Q000648:ultrastructure*; D034281:Dynamins; D004705:Endocytosis / Q000502:physiology; D011992:Endosomes / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000737:chemistry / Q000502:physiology*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D008969:Molecular Sequence Data
D000199:Actins; D020558:GTP Phosphohydrolases; D034281:Dynamins