Effect of cadmium on Pekin duck total body water, water flux, renal filtration, and salt gland function.
The following hypotheses were examined using Pekin ducks (Anas platyrhynchos) as a model for marine ducks: cadmium (Cd) intake affects (1) salt gland and/or kidney function of ducks and (2) osmoregulation differently in male and female ducks. Birds were fed 0, 50, or 300 microg Cd/g food. They were gradually acclimated to 450 mM NaCl and then drank 300 mM NaCl for 3 mo while salt gland secretion (SGS), glomerular filtration rate (GFR), total body water (TBW), and water flux (WF) were measured in ducks eating control and high-Cd diets. Cadmium ingestion did not markedly affect body mass, but significantly enlarged the salt glands and kidneys. Enhancement of kidney mass was greater in males. Cadmium ingestion did not affect TBW or WF, but tended to increase interstitial fluid space at the expense of intracellular fluid. Sex did not affect TBW, but males had greater WF. Birds that ate Cd diets, especially the higher Cd diet, exhibited renal tubular damage and lower GFR. Ducks that ate Cd had lower plasma sodium concentration and osmolality and, to activate SGS, required longer infusion of NaCl and larger increments
Bennett
D C
DC
Department of Zoology, University of British Columbia, Vancouver, Canada.
Hughes
M R
MR
Elliott
J E
JE
Scheuhammer
A M
AM
Smits
J E
JE
D000818:Animals; D001834:Body Water / Q000187:drug effects / Q000378:metabolism*; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D004032:Diet; D004372:Ducks / Q000502:physiology*; D004435:Eating / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D012491:Salt Gland / Q000187:drug effects* / Q000378:metabolism; D014018:Tissue Distribution; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002104:Cadmium