Functional reconstitution of thymopoiesis after human immunodeficiency virus infection.
We have utilized combination antiretroviral therapy following human immunodeficiency virus type 1-induced human CD4(+) thymocyte depletion in the SCID-hu mouse to examine the immune competence of reconstituting thymocytes which appear following administration of combination therapy. These cells express a normal distribution of T-cell receptor variable gene families and are responsive to costimulatory signals. These results suggest that normal thymic function may be restored following antiretroviral treatment.
Kitchen
S G
SG
Division of Hematology-Oncology, Department of Medicine and UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, California 90095, USA.
Killian
S
S
Giorgi
J V
JV
Zack
J A
JA
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016049:Didanosine / Q000494:pharmacology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D017320:HIV Protease Inhibitors / Q000494:pharmacology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D019469:Indinavir / Q000494:pharmacology; D051379:Mice; D016513:Mice, SCID; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D015215:Zidovudine / Q000494:pharmacology
D017320:HIV Protease Inhibitors; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine; D019469:Indinavir; D016049:Didanosine