title: Renal dopamine and noradrenaline excretion during CNS-induced natriuresis in spontaneously hypertensive rats: influence of dietary sodium.
abstract: Abnormalities in dopamine (DA) and noradrenaline (NA) activities and sodium handling may be involved in the pathogenesis of hypertension. The present study was designed to investigate whether any differences exist between normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) in urinary excretion of DA, NA and sodium after 15 weeks on a low, medium or high sodium diet and during a subsequent elevation of the cerebroventricular fluid sodium concentration (CNS-induced natriuresis). Seven features were noted: (1) Basal sodium and DA excretion after the diet regimen was correlated to the dietary sodium content in both strains, except that sodium and DA excretion in SHR showed no further increase after the high sodium diet over and above that after medium sodium diet. (2) For any given sodium diet, SHR excreted more DA and NA as compared with WKY. (3) Blood pressure in SHR, as opposed to that in WKY, was higher after medium and high sodium diet than after low sodium diet. (4) During CNS-induced natriuresis NA excretion decreased or remained unchanged in WKY, but increased in SHR. (5) The DA/NA excretion ratio during CNS-induced natriuresis increased in WKY while decreased in SHR, which would not favour a natriuretic/vasodilatory response in the latter. (6) The ability of SHR to respond with CNS-induced natriuresis was attenuated after high sodium diet. (7) The magnitude of CNS-induced natriuresis was in both strains correlated to the sodium diet; the higher the dietary sodium content, the greater the natriuretic response. In conclusion, the study shows some clear differences in the catecholamine and sodium handling between WKY and SHR which may be involved in the pathogenesis of hypertension in SHR. Furthermore, increased sodium in the diet sensitizes the brain and kidney to increase the ability to respond with natriuresis for a given sodium stimulus.
authors.affiliation: Department of Physiology, University of Uppsala, Biomedical Center, Uppsala, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Hansell
authors.forename: B
authors.initials: B
authors.lastname: Isaksson
authors.forename: M
authors.initials: M
authors.lastname: Sjöquist
authors.forename: M S
authors.initials: MS
authors.lastname: Jöquist
mesh_terms: D000818:Animals; D004039:Diet, Sodium-Restricted; D004298:Dopamine / Q000652:urine*; D006973:Hypertension / Q000503:physiopathology* / Q000652:urine; D007668:Kidney / Q000378:metabolism*; D009318:Natriuresis; D009638:Norepinephrine / Q000652:urine*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012016:Reference Values; D012964:Sodium / Q000134:cerebrospinal fluid*; D012982:Sodium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012982:Sodium, Dietary; D012964:Sodium; D004298:Dopamine; D009638:Norepinephrine