Allogeneic hematopoietic stem cell transplantation: current issues and future prospects.
Major developments have occurred in the field of hematopoietic stem cell transplantation since the first successful transplants from HLA-identical siblings in the late 60's. The formally experimental procedure has become established therapy for a number of congenital or acquired disorders of the hematopoietic system and for chemotherapy-sensitive malignancies. Reduced transplant-related mortality has led to a widening of indications. The present review summarizes current issues and future prospects in allogeneic stem cell transplantation. These issues and prospects will include; stem cell sources, alternative donors, graft-versus-host disease, indications and long-term survival following allogeneic stem cell transplantation.
Socié
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Service de Greffe de Moelle, Hôpital Saint-Louis, Paris, France. gsocie@chu-stlouis.fr
Gluckman
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D000208:Acute Disease; D000328:Adult; D000367:Age Factors; D000741:Anemia, Aplastic / Q000151:congenital / Q000628:therapy; D002648:Child; D005312:Fetal Blood; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors