title: Aortic stiffness as a risk factor for recurrent acute coronary events in patients with ischaemic heart disease.
abstract: OBJECTIVE
  Aortic elasticity is an important determinant of left ventricular performance and coronary blood flow. Moreover, it has been shown that aortic elastic properties deteriorate in patients with coronary artery disease. However, the predictive role of aortic elasticity in the occurrence of coronary events, has not been addressed so far. Therefore, we set out to test prospectively the hypothesis that invasive as well as non-invasive measures of aortic elastic properties, assessed at rest from pressure-diameter relationships, could predict the development of recurrent coronary events.
  
  
  RESULTS
  Clinical variables and measures of aortic function were assessed in 54 normotensive patients with coronary artery disease. The aortic pressure-diameter relationship was derived invasively with a high-fidelity Y shaped catheter (developed in our Institution) for aortic diameter measurements, simultaneously with a Millar catheter for aortic pressure measurements. Aortic root distensibility was assessed by non-invasive techniques. During an average of 3 years follow-up, 12 of 54 patients either developed unstable angina (n=8) or acute myocardial infarction (n=4). By multivariate Cox model analysis, aortic stiffness was the strongest predictor of progression to any end-point (relative risk: 3.24, CI: 1.79 to 5.83;P=0.000). When aortic stiffness was not considered, aortic distensibility was the only independent predictor for acute coronary syndromes (relative risk: 0.37 CI: 0.21 to 0.65;P=0.000).
  
  
  CONCLUSIONS
  In patients with coronary artery disease, aortic elastic properties are powerful and independent risk factors for recurrent acute coronary events.
authors.affiliation: Hippokration Hospital, Department of Cardiology, University of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
authors.forename: J
authors.initials: J
authors.lastname: Dernellis
authors.forename: E
authors.initials: E
authors.lastname: Tsiamis
authors.forename: C
authors.initials: C
authors.lastname: Stratos
authors.forename: L
authors.initials: L
authors.lastname: Diamantopoulos
authors.forename: A
authors.initials: A
authors.lastname: Michaelides
authors.forename: P
authors.initials: P
authors.lastname: Toutouzas
mesh_terms: D001011:Aorta / Q000503:physiopathology*; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000453:epidemiology* / Q000503:physiopathology; D004452:Echocardiography; D004548:Elasticity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000503:physiopathology; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors