title: Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel.
abstract: BACKGROUND
  Injectable hyaluronic acid gel is a non-animal biomaterial used for soft tissue augmentation.
  
  
  OBJECTIVE
  The dermal implantation of this naturally occurring polysaccharide is reported to be well tolerated by patients, with a longer duration in tissue than bovine collagen without any major local or systemic side effects. We report a case of an acute hypersensitivity reaction in a woman after her third injection for improvement of melolabial fold wrinkles.
  
  
  METHODS
  An adverse granulomatous-like response to the intradermal injection of a modified hyaluronic acid gel is described.
  
  
  RESULTS
  The patient developed indurated and erythematous papulocystic nodules in the melolabial folds bilaterally at the sites of injection.
  
  
  CONCLUSIONS
  Injectable hyaluronic acid gel can be associated with severe allergic reactions and patients should be warned of this possible treatment side effect.
authors.affiliation: Washington Institute of Dermatologic Laser Surgery, Washington, D.C. 20037, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Lupton
authors.forename: T S
authors.initials: TS
authors.lastname: Alster
mesh_terms: D000208:Acute Disease; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005260:Female; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007271:Injections, Intradermal; D008875:Middle Aged; D012008:Recurrence; D015595:Skin Aging / Q000187:drug effects; D012871:Skin Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy
chemical_list: D001672:Biocompatible Materials; D005782:Gels; D006820:Hyaluronic Acid