Dynamic characteristics and adaptability of reflex eye movements of Fyn-kinase-deficient mice.
Fyn-kinase is expressed widely in the entire brain, including the cerebellum. Fyn-kinase-deficient mice are known to exhibit hypersensitivity to ethanol. To evaluate the cerebellar functions of Fyn-kinase, we examined the dynamic characteristics of the horizontal optokinetic response (HOKR) and vestibulo-ocular reflex (HVOR) and its adaptability in Fyn-kinase-deficient mice. The HOKR was induced by sinusoidal oscillation of a checkered screen and the HVOR was induced by sinusoidal oscillation of a turntable in darkness. The HOKR gains of mutant mice were higher than those of the wild-type mice, and the HVOR phases of mutant mice were less advanced than those of the wild-type mice. However, no difference was noted in the adaptability of the HOKR induced by 1 h of sustained screen oscillation between the mutant and wild-type mice. The cerebellar functions appear to be unaffected by Fyn-kinase knockout.
Kitazawa
H
H
Department of Physiology, Jichi Medical School, Yakushiji 3311, Minamikawachi, Tochigi, Japan. hiromasa@jichi.ac.jp
Katoh
A
A
Yagi
T
T
Nagao
S
S
D000818:Animals; D003624:Darkness; D006720:Homozygote; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D017120:Nystagmus, Optokinetic / Q000502:physiology*; D009991:Oscillometry; D010775:Photic Stimulation; D011505:Protein-Tyrosine Kinases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051076:Proto-Oncogene Proteins c-fyn; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*
D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn