Accessory molecules for MHC class II peptide loading.
Accessory molecules, such as HLA-DM and invariant chain, modulate the ligands bound to MHC class II molecules in antigen-presenting cells. Recent investigations, including gene targeting experiments, have shed light on the functions of these molecules, their mechanisms of action, interactions with class II molecules, and the relationships with associated molecules such as tetraspanins and HLA-DO.
Busch
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R
Department of Pediatrics, Stanford University Medical Center, Stanford, CA 94305-5208, USA. rbusch@leland.stanford.edu
Doebele
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RC
Patil
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NS
Pashine
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A
Mellins
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D000818:Animals; D017951:Antigen Presentation; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006681:HLA-D Antigens / Q000276:immunology / Q000378:metabolism; D015803:HLA-DR3 Antigen / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D011485:Protein Binding
D000944:Antigens, Differentiation, B-Lymphocyte; C416186:H-2O antigen; C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; C046148:HLA-DO antigens; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; C045084:invariant chain