Prospects for genetic therapy of cardiovascular disease.
Significant progress has been made in cardiovascular gene therapy. Further investigations are required to understand the basic science of vectors, mechanisms of gene delivery, vector-associated immunogenicity, and pathophysiology of vascular and myocardial diseases. In addition, catheter and stent devices will be required to deliver vectors to the vasculature and myocardium (Fig. 3). Despite these scientific challenges, molecular therapies for cardiovascular diseases are being implemented into clinical practice.
Duckers
H J
HJ
Department of Experimental Cardiology, Erasmus University of Rotterdam, Netherlands.
Nabel
E G
EG
D000818:Animals; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000235:genetics / Q000628:therapy*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics / Q000628:therapy*; D016896:Treatment Outcome