Signal transduction and cellular radiation responses.
Exposure of cells to ionizing radiation results in complex cellular responses resulting in cell death and altered proliferation states. The underlying cytotoxic, cytoprotective and cellular stress responses to radiation are mediated by existing signaling pathways, activation of which may be amplified by intrinsic cellular radical production systems. These signaling responses include the activation of plasma membrane receptors, the stimulation of cytoplasmic protein kinases, transcriptional activation, and altered cell cycle regulation. From the data presented, there is increasing evidence for the functional links between cellular signal transduction responses and DNA damage recognition and repair, cell survival, or cell death through apoptosis or reproductive mechanisms.
Schmidt-Ullrich
R K
RK
Department of Radiation Oncology Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
Dent
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Grant
S
S
Mikkelsen
R B
RB
Valerie
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K
D000818:Animals; D002518:Ceramides / Q000378:metabolism; D016207:Cytokines / Q000528:radiation effects; D004249:DNA Damage; D005609:Free Radicals; D006801:Humans; D018384:Oxidative Stress; D011830:Radiation Effects; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
D002518:Ceramides; D016207:Cytokines; D005609:Free Radicals; D011956:Receptors, Cell Surface