title: Myocardial perfusion scanning in patients considered for late arterial switch.
abstract: BACKGROUND
  Our aims were to evaluate left ventricular uptake of radionuclide in patients with Mustard's or Senning's procedure, comparing them with patients who had undergone banding of the pulmonary trunk and conversion to the arterial switch.
  
  
  METHODS
  Technetium perfusion scans were performed on 27 patients (25 male), aged from 10 to 28 years with a mean of 17.8 years and a standard deviation of 5.8 years, who had undergone Mustard's or Senning's procedure for correction of complete transposition. Of the 27 patients, six had been accepted for staged conversion to an arterial switch. At the time of the study, two of the six patients had undergone completion to the switch and four had undergone banding of the pulmonary trunk with two then proceeding to the arterial switch. Cardiac catheterisation to measure left ventricular pressure was performed in all six patients and scores for left ventricular uptake of isotope were compared with echocardiographic index of the thickness of the left ventricular posterior wall and measurements of left ventricular pressure.
  
  
  RESULTS
  Uptake of isotope by the left ventricle was generally poor, but was higher in patients following banding and conversion to the arterial switch, as well as in two patients with native obstruction of the left ventricular outflow tract, and one other who subsequently was found to have pulmonary venous obstruction. There was a positive correlation between the thickness of the left posterior wall in diastole and left ventricular uptake of isotope (r = 0.74, p < 0.05). There also a positive correlation between left ventricular pressure and uptake of the isotope (r = 0.68, p < 0.05).
  
  
  CONCLUSIONS
  Uptake of radionuclide by the left ventricle after Mustard's or Senning's procedure for complete transposition appears to reflect ventricular pressure and myocardial mass. A prospective study would be required to determine the predictive ability of such scans regarding the ultimate outcome of conversion to arterial switch, but our initial findings suggest that the technique provides an additional non-invasive method of monitoring left ventricular response to pulmonary arterial banding.
authors.affiliation: Royal Hospital for Sick Children, Yorkhill NHS Trust, Glasgow, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: McLeod
authors.forename: J
authors.initials: J
authors.lastname: De Giovanni
authors.forename: E
authors.initials: E
authors.lastname: Silove
authors.forename: H
authors.initials: H
authors.lastname: Alton
authors.forename: R
authors.initials: R
authors.lastname: Poyner
authors.forename: W
authors.initials: W
authors.lastname: Brawn
mesh_terms: D000293:Adolescent; D000328:Adult; D006328:Cardiac Catheterization; D002648:Child; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D013667:Technetium; D014188:Transposition of Great Vessels / Q000000981:diagnostic imaging* / Q000601:surgery*; D016277:Ventricular Function, Left
chemical_list: D013667:Technetium