title: [Serological study of hepatitis C virus NS5 protein epitopes and their clinical and diagnostic significance].
abstract: Three peptides corresponding to the 2295-2317 aa NS5 HCV region and individual parts of this region were synthesized. Antigenic properties of these peptides were investigated. The 2295-2317 aa region contains at least two epitopes of different nature. The full-sized peptide is more promising for the diagnostic studies. Optimal conditions for ELISA with this peptide were defined, allowing the maximum complete utilization of the potentialities of both epitopes.
authors.forename: I V
authors.initials: IV
authors.lastname: Kruglov
authors.forename: O O
authors.initials: OO
authors.lastname: Znoĭko
authors.forename: M P
authors.initials: MP
authors.lastname: Finogenova
authors.forename: O L
authors.initials: OL
authors.lastname: Ogienko
authors.forename: M V
authors.initials: MV
authors.lastname: Ianina
authors.forename: N A
authors.initials: NA
authors.lastname: Sergeeva
authors.forename: D M
authors.initials: DM
authors.lastname: Braginskiĭ
authors.forename: N V
authors.initials: NV
authors.lastname: Doroshenko
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Semiletov
mesh_terms: D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000097:blood*; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D017361:Viral Nonstructural Proteins / Q000276:immunology*; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000939:Epitopes; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase