[Application of multi-tumor markers in ovarian carcinoma].
OBJECTIVE
To improve the specificity and sensitivity of diagnosis and to strengthen postoperative monitoring for patients with ovarian cancer.


METHODS
Sera obtained from patients-ovarian epithelial carcinoma (67 cases), benign ovarian tumor (33 cases) and from donor (38 cases) as control. Serologic examination of 5 tumor markers--SA, LSA, CA125, CP2, and 6B11Ab2 was performed.


RESULTS
The sensitivity and specificity in diagnosis of ovarian cancer were 83.6% and 85.9% respectively for CA125 alone (> 35 kU/L) whereas 86.6% and 94.4% respectively for multi-tumor markers combined in which 3 or more indices showed positive. In addition, serial measurements of multi-tumor markers have been done for 1 year after operation in 24 cases of ovarian epithelial carcinoma. The correlations between the levels of multi-tumor markers either and the results of second look operation or and clinical manifestation of recurrence were analyzed.


CONCLUSIONS
Multi-tumor markers examination could improve the diagnosis of ovarian cancer and early detection of recurrence.
Feng
J
J
Gynecological Oncology Center, People's Hospital, Beijing Medical University.
Qian
H
H
Tian
Y
Y
D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood*; D018269:Carcinoma, Endometrioid / Q000097:blood; D018284:Cystadenocarcinoma, Serous / Q000097:blood; D018293:Cystadenoma, Serous / Q000097:blood; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood*
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen