[Expression and significance of p53, c-erbB2, CEA proteins in colorectal adenoma and carcinoma].
Expression of p53, c-erB2, CEA proteins in 15 cases of normal colorectal mucosa, 40 adenoma and 40 carcinoma of colon were studied with immunohistochemistry. The positive rate of p53, c-erbB2, CEA in colorectal carcinomas were significantly higher than those in adenoma. The positive rate of p53 in adenoma with severe atypical hyperplasia was higher than that in the mild (P< 0.01), and was higher in colorectal carcinomas of poor differentiation that that in the well-differentiated ones (P< 0.05). The novel type monoclonal antibody of CEA Col-1 had a high sensitivity and specificity for the tissue of colorectal carcinoma in which the positive rate was 85%. The results suggested the alteration p53, c-erbB2 are involve in the tumorgenesis and development of colorectal carcinoma; and detection of p53, c-erbB2 and CEA proteins are helpful in distinguishing benign and malignant polyps of colon.
Shu
M
M
Department of Microbiology, Hunan Medical University, Changsha.
Liu
S
S
Yu
P
P
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism*; D000236:Adenoma / Q000235:genetics / Q000378:metabolism*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53