title: Treatment of ligature-induced peri-implantitis defects by regenerative procedures: a clinical study in dogs.
abstract: We carried out a clinical evaluation of the hard tissue fill following treatment of ligature-induced peri-implantitis in dogs. Four dogs were used and their mandibular premolars (P2, P3 and P4) were removed. After 3 months of healing, two titanium implants were placed on each side of the mandible. After 3 months, the abutment connection was performed, and experimental peri-implantitis was induced by placement of cotton ligatures in a submarginal position. The ligatures and abutments were removed after one month, and the peri-implant bone defects were assigned randomly to one of the treatments: debridement (control), debridement plus guided bone regeneration (GBR), debridement plus mineralized bone graft (BG), and debridement plus guided bone regeneration associated with a mineralized bone graft (GBR + BG). Clinical measurements of the peri-implant bone defects before and 5 months after treatment revealed no statistically significant differences between the defects treated by GBR, BG and GBR + BG. These 3 treatment methods provided more hard tissue fill than debridement alone (p < 0.05). Thus, it can be concluded that GBR, BG or a combination of the two techniques can enhance the hard tissue fill in defects caused by peri-implantitis in dogs.
authors.affiliation: Department of Prosthesis and Periodontology, University of Campinas, Piracicaba, S.P., Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Machado
authors.forename: C M
authors.initials: CM
authors.lastname: Stefani
authors.forename: E A
authors.initials: EA
authors.lastname: Sallum
authors.forename: A W
authors.initials: AW
authors.lastname: Sallum
authors.forename: V A
authors.initials: VA
authors.lastname: Tramontina
authors.forename: F H
authors.initials: FH
authors.lastname: Nociti Júnior
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001641:Bicuspid; D001861:Bone Regeneration; D015921:Dental Implants / Q000009:adverse effects*; D004195:Disease Models, Animal; D004285:Dogs; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods* / Q000706:statistics & numerical data; D008026:Ligation / Q000009:adverse effects; D008334:Mandible; D010518:Periodontitis / Q000209:etiology / Q000628:therapy*; D011897:Random Allocation; D013997:Time Factors; D014025:Titanium
chemical_list: D015921:Dental Implants; D014025:Titanium