TMC-171A,B,C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282.
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
Kohno
J
J
Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, Japan.
Asai
Y
Y
Nishio
M
M
Sakurai
M
M
Kawano
K
K
Hiramatsu
H
H
Kameda
N
N
Kishi
N
N
Okuda
T
T
Komatsubara
S
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008358:Mannose / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003904:Mitosporic Fungi / Q000378:metabolism*; D008968:Molecular Conformation; D014885:Waxes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; C405182:TMC 154; C405183:TMC 171A; C405184:TMC 171B; C405185:TMC 171C; D014885:Waxes; D008358:Mannose