The brain and thymus have much in common: a functional analysis of their microenvironments.
Research into the neural and immune systems has begun to converge. Since the first reports that interleukins play important roles in both systems and that lymphocytes secrete neuronal factors, scientists have been surprised by the ever-increasing list of interactions. Here, Rolf Mentlein and Marion Kendall examine the major supporting cells of the brain and thymus - astrocytes and thymic epithelial cells - the similar neuroectodermal origin of which could explain such fundamental analogies.
Mentlein
R
R
Anatomisches Institut, Universität Kiel, D-240988 Kiel, Germany. rment@anat.uni-kiel.de
Kendall
M D
MD
D000818:Animals; D001921:Brain / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D004847:Epithelial Cells / Q000276:immunology; D006801:Humans; D009432:Neural Crest / Q000276:immunology; D009457:Neuroglia / Q000276:immunology; D015213:Neuroimmunomodulation; D013950:Thymus Gland / Q000276:immunology*
D016207:Cytokines