[Effects of low concentration ozone on the respiratory system of mice].
Effects of low concentration of O3 on the respiratory system in mice were studied in the present study. Mice were exposed to 0.1, 0.25 and 1.0 mg/m3 of O3, respectively for 8 h per day for 3 days. Cilia in brochia, Lipid peroxide (LPO) in lung tissue and phagocytic function of macrophage in mice were examined. The results showed that there were cilia damage in the 1.0 mg/m3 group and swelling of mitochondrias as well as endoplasmic reticulums in the 0.25 mg/m3 group. But no damage was found in the group of 0.1 mg/m3. Furthermore, phagocytic rates in the 0.25 and 1.0 mg/m3 groups were significantly lower than that of control group (P < 0.01). No differences in LPO leads were found.
Li
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D
Department of Environmental Health, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
Yu
G
G
Song
H
H
Lian
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X
D000818:Animals; D001980:Bronchi / Q000648:ultrastructure; D002923:Cilia / Q000648:ultrastructure; D004781:Environmental Exposure; D008054:Lipid Peroxides / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010126:Ozone / Q000009:adverse effects*; D012137:Respiratory System / Q000187:drug effects*
D008054:Lipid Peroxides; D010126:Ozone