Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats.
The effect of dl-alpha-lipoic acid on lipid peroxidation and antioxidants status has been studied in the blood of young and aged rats. dl-alpha-lipoic acid, an antioxidant, was administered intraperitoneally for 7 and 14 days. Enzymatic and non-enzymatic antioxidant levels decreased with age but this decrease was attenuated by dl-alpha-lipoic acid. Lipid peroxide levels increased with age, and were decreased by lipoic acid administration. These results suggest that biochemical lesions which are considered to be part of the normal ageing process are neutralized by dl-alpha-lipoic acid.
Arivazhagan
P
P
Department of Medical Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India.
Juliet
P
P
Panneerselvam
C
C
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology*
D000975:Antioxidants; D008063:Thioctic Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione