Application of cross-impact analysis to the relationship between aldehyde dehydrogenase 2 allele and the flushing syndrome.
The experimental approach has been used to study successfully the relationship between the polymorphism of aldehyde dehydrogenase 2 and the flushing syndrome. In the present study, a probabilistic approach was used to analyse this relationship. Using cross-impact analysis and experimental data, the probability of the occurrence of flushing, the extent by which ALDH2*2/*2 enhances flushing more than ALDH2*1/*2, the extent by which ALDH2*1/*1 enhances non-flushing more than ALDH2*1/*2, etc. can be calculated. Two examples are given to show the potential use of cross-impact analysis.
Wu
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Department of Medico-Biocybernetics, Faculty of Medico-Biology, Russian State Medical University, Moscow 117437, Russia.
D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D005483:Flushing / Q000235:genetics*; D006801:Humans; D015233:Models, Statistical; D011110:Polymorphism, Genetic / Q000235:genetics; D013577:Syndrome
C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial