Differential neurotrophin levels in cerebrospinal fluid and their changes during development in newborn rat.
Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND 1-21. NGF levels decreased from PND 1-3 to PND 9. At PND 15 and 17, NGF levels peaked a second time and rapidly decreased to PND 21. BDNF peaked at PND 13-15, while NT-3 levels peaked at PND 7-9. Each of the three neurotrophins has its own characteristic pattern in changes in cerebrospinal fluid levels.
Xia
Y X
YX
Department of Obstetrics and Gynaecology, Miyazaki Medical College, 5200 Kihara, Kiyotake-Cho, Miyazaki, Japan.
Ikeda
T
T
Xia
X Y
XY
Ikenoue
T
T
D000375:Aging / Q000134:cerebrospinal fluid*; D000818:Animals; D000831:Animals, Newborn; D019208:Brain-Derived Neurotrophic Factor / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D009414:Nerve Growth Factors / Q000134:cerebrospinal fluid*; D020933:Neurotrophin 3 / Q000134:cerebrospinal fluid*; D051381:Rats; D017208:Rats, Wistar
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020933:Neurotrophin 3