[Bone histomorphometric changes in ovariectomized goat at different time courses].
Using histopatholoical method, we investigated the bone histomorphometric changes in ovariectomied goats at different time courses. Eight goats, female, aged one and a half years, were randomly divided into two groups, the control and the ovariectomy (OVX). Iliac crest biopsies were separately processed before ovariectomy and at 60 days, 120 days and 180 days after ovariectomy. The histomorphometric changes were observed. It was found that the bone structure in trabecular bone remained relatively constant in the control group throughout the whole study. In contrast, the trabecular quantity was slightly decreased and the trabeculae were disconnected in OVX at 60 days after ovariectomy. The bone structure was characterized by the thinning of the trabeculae, the further discontinuance and quantity loss of trabeculae, and the anlargement of marrow cavity at 120 days to 180 days after ovariectomy. Apparently, these bone structural changes manifested with typical osteopenia pathological changes. Our results may serve as a basis for the design of further studies using OVX goat as an animal model for postmenopausal osteoporosis.
Li
L
L
Biomedical Engineering Research Unit, School of Basic Medicine Sciences, Chengdu.
Wu
W
W
Chen
H
H
Tan
J
J
Zheng
H
H
Weng
L
L
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006041:Goats; D006801:Humans; D007085:Ilium / Q000473:pathology; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000473:pathology*; D010052:Ovariectomy; D013997:Time Factors