title: Synthesis of both enantiomers of 4-vinyl oxazolidin-2-one from a single precursor: D-isoascorbic acid.
abstract: A convenient synthesis of (S)- and (R)-4-vinyl oxazolidin-2-one 1 and 2 from the same inexpensive starting material, D-isoascorbic acid, is described. The title compounds were obtained in 44% and 38% yield, respectively, by operationally simple steps. This approach is a suitable alternative to the literature methods and enhances the synthetic utility of these intermediates. Inc.
authors.affiliation: Centro di Studio per la Chimica dei Recettori e delle Molecole Biologicamente Attive-Istituto di Chimica, Università Cattolica del S. Cuore, Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Delle Monache
authors.forename: D
authors.initials: D
authors.lastname: Misiti
authors.forename: P
authors.initials: P
authors.lastname: Salvatore
authors.forename: G
authors.initials: G
authors.lastname: Zappia
mesh_terms: D001205:Ascorbic Acid; D010080:Oxazoles / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D010080:Oxazoles; C005056:isoascorbic acid; D001205:Ascorbic Acid