[Prognosis prediction of S-phase fraction and p53, c-erbB-2, estrogen receptor, progesterone receptor in axillary node-negative breast cancer].
The prognostic factors in 180 axillary node-negative breast cancer patients with more than 5 year follow-up were searched for with multiple regression. Based on the regression results, the cases with treatment failure in 5 year and the cases with 5 year disease free survival were matched at 1:2 ratio. Then the c-erbB-2 protein, p53 Protein, estrogen receptor (ER), progesterone receptor (PR) and the S-phase fraction (SPF) were measured in paraffin-embedded breast cancer tissue. The results were analysed with log-rank test and Cox-Model. Among the biobehaviour factors measured, the SPF was the strongest prognosis predictor for ANN. The 5 year disease free survival rate of ANN with SPF < 10% or > 10% was 94% and 52% respectively (P < 0.001). The treatment failure relative risk of patients with SPF > 10% ANN was 11.31. The relative risk of other four factors was respectively, PR 3.58 (P < 0.002), ER 2.93 (P < 0.05), p53 1.44 (P > 0.3), c-erbB-2 1.38 (P > 0.5). The combination of PR or EP with SPF could make the relative risk even higher.
Zhang
S
S
Department of Oncology, Second Hospital, Zhejiang Medical University, Hangzhou.
Yuan
Y
Y
Wang
X
X
D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D016555:Matched-Pair Analysis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D012307:Risk Factors; D016196:S Phase; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53