title: Development of neuron-neuron synapses.
abstract: Our understanding of neuronal synapse development has advanced in recent years. The development of glycinergic synapses appears to depend on gephyrin and glycine receptor activity. Molecular characterization of the structure and development of glutamatergic synapses is in progress, but the underlying mechanisms remain unclear. Activity-dependent mechanisms and specific molecules that regulate the morphological development of dendritic spines have recently been identified.
authors.affiliation: Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114,USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Sheng
mesh_terms: D000818:Animals; D003712:Dendrites / Q000378:metabolism; D006801:Humans; D009045:Motor Endplate / Q000737:chemistry / Q000378:metabolism; D009414:Nerve Growth Factors / Q000378:metabolism / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009420:Nervous System / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D013569:Synapses / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
chemical_list: D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D017470:Receptors, Glutamate