title: Clinical evaluation of the effect of a remineralizing toothpaste on dentinal sensitivity.
abstract: Dentinal hypersensitivity is a common dental problem without a satisfactory solution. Most therapies have focused on either trying to block the stimulation of dentinal nerves or on sealing open dentinal tubules. This study evaluated, in a double blind clinical trial, the effect of Enamelon, a dentifrice containing sodium fluoride, calcium salts and phosphate salts (calcium separated from the phosphate and fluoride by a plastic divider in the tube to prevent interaction) on dentinal hypersensitivity over an 8-week period. A conventional OTC dentifrice containing NaF without calcium and phosphate enhancement served as the control. A third dentifrice, containing sodium monofluorophosphate enhanced by calcium and phosphate salts, was also tested. Based upon subjective anecdotal information, net numbers of sensitive teeth which became non-sensitive, and a logit analysis of the change in the proportion of sensitive teeth over the study time period, Enamelon was the most effective product, and the OTC control the least effective.
authors.affiliation: Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, USA. hkaufman@notes.cc.sunysb.edu
authors.forename: H W
authors.initials: HW
authors.lastname: Kaufman
authors.forename: M S
authors.initials: MS
authors.lastname: Wolff
authors.forename: A E
authors.initials: AE
authors.lastname: Winston
authors.forename: C W
authors.initials: CW
authors.lastname: Triol
mesh_terms: D000704:Analysis of Variance; D002118:Calcium; D002130:Calcium Phosphates / Q000737:chemistry / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D016015:Logistic Models; D008297:Male; D010710:Phosphates / Q000627:therapeutic use; D018709:Statistics, Nonparametric
chemical_list: D002130:Calcium Phosphates; D003802:Dentifrices; C118793:Enamelon; D010710:Phosphates; C012980:fluorophosphate; D005459:Fluorides; D002118:Calcium