Genetic and embryological approaches to studies of neural tube defects: a critical review. NTD Collaborative Group.
Experimental embryological models have suggested that the morphology and quantity of neural tube defects may be governed by their position along the anteroposterior axis of the embryo. Inductive interactions and genetic regulation during axis development may play a role in the patterning of neural tube defects. A major challenge in the study of human neural tube defects is determining whether the spectrum of developmental neural tube anomalies found in individuals and their families mirror experimental models and are regulated by similar processes. We have found that the various neural tube defect phenotypes can be clustered according to their position along the anteroposterior axis. The findings correlate well to the pattern of early genes expression, inductive models of the embryonic axis, and mutant NTD animal models. We suggest that NTD should be studied by their location along the anteroposterior axis and that specific mutant genes may be identified by the observed pattern of NTD in an individual or a family.
George
T M
TM
Pediatric Neurosurgery Service, Duke University Medical Center, Durham, NC 27705, USA.
Speer
M C
MC
D000818:Animals; D019521:Body Patterning; D001921:Brain / Q000002:abnormalities / Q000196:embryology*; D004475:Ectoderm / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D009420:Nervous System / Q000196:embryology; D009436:Neural Tube Defects / Q000196:embryology* / Q000235:genetics*