title: An evaluation of fluid bed drying of aqueous granulations.
abstract: The purpose of the work described was twofold: (a) to apply heat and mass balance approaches to evaluate the fluid bed drying cycle of an aqueous granulation, and (b) to determine the effect of the temperature and relative humidity of the drying air on the ability to meet a predetermined moisture content specification. Water content determinations were performed using Karl Fischer titration, and Computrac and Mark 1 moisture analyzers. The water vapor sorption isotherms were measured using a gravimetric moisture sorption apparatus with vacuum-drying capability. Temperature, relative humidity, and air flow were measured during the drying cycle of a production-scale fluid bed dryer. Heat and mass balance equations were used to calculate the evaporation rates. Evaporation rates calculated from heat and mass balance equations agreed well with the experimental data, whereas equilibrium moisture content values provided useful information for determination of the upper limit for inlet air humidity. Increasing the air flow rate and inlet temperature reduced the drying time through the effect on the primary driving force. As expected, additional drying of granules during the equilibration period did not show a significant impact on reducing the final moisture content of granules. Reducing the drying temperature resulted in measurement of higher equilibrium moisture content for the granules, which was in good agreement with the water vapor sorption data. Heat and mass balance equations can be used to successfully model the fluid bed drying cycle of aqueous granulations. The water vapor sorption characteristics of granules dictate the final moisture content at a given temperature and relative humidity.
authors.affiliation: Process Development Center, Abbott Laboratories, Abbott Park, Illinois 60064-4000, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Hlinak
authors.forename: A
authors.initials: A
authors.lastname: Saleki-Gerhardt
mesh_terms: D000327:Adsorption; D000388:Air; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D006112:Gravitation; D006358:Hot Temperature; D006813:Humidity; D012995:Solubility; D014618:Vacuum; D014867:Water / Q000032:analysis* / Q000737:chemistry
chemical_list: D014867:Water