title: Enhanced platelet aggregation, high homocysteine level, and microvascular disease in diabetic muscle infarctions: implications for therapy.
abstract: Muscle infarction is a rare complication in patients with diabetes mellitus, probably because of the rich vascular supply of this tissue. We describe a patient with type 1 diabetes who had infarction of the muscles in her right thigh. We report, for the first time, that the patient, in addition to an advanced microvascular disease in the muscle, had increased plasma total homocysteine levels and increased platelet aggregation. These pathologies might have a synergistic effect on the development of this rare complication and should be treated aggressively to prevent further episodes.
authors.affiliation: Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: V
authors.initials: V
authors.lastname: Rajkumar
authors.forename: P
authors.initials: P
authors.lastname: Ragatzki
authors.forename: A
authors.initials: A
authors.lastname: Sima
authors.forename: J
authors.initials: J
authors.lastname: Levy
mesh_terms: D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood / Q000150:complications* / Q000473:pathology; D005260:Female; D005492:Folic Acid / Q000627:therapeutic use; D006397:Hematinics / Q000627:therapeutic use; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007238:Infarction / Q000097:blood / Q000150:complications* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D017566:Microvascular Angina / Q000209:etiology* / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology; D010974:Platelet Aggregation / Q000502:physiology*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D006397:Hematinics; D010975:Platelet Aggregation Inhibitors; D006710:Homocysteine; D005492:Folic Acid; D001241:Aspirin