title: [Clinicopathological and immunohistochemical study of hepatoblastoma].
abstract: To investigate the relationship between immunoreaction of histologic subtype and prognosis, this paper analysed the clinicopathological data from 20 cases of hepatoblastoma. Immunohistochemical staining was performed in 18 cases. The results showed that cytopolasmic postivities of epithlial tumor cells were observed by CK, AFP, S-100 protein and vimentin in 14, 10, 9 and 4 cases respectively. Positive staining for CEA was seen in the nuclei of epithelial tumor cells in 11 cases. Nuclear P53 protein staining was found in 9 cases. Nuclear and cytoplasmic postivities of P16 protein were observed in 7 cases. S-100 protein, vimentin, CK and P16 protein were detected in mesenchymal component in 1 case. This study suggested that immunoreactions of hepatoblastomas were different in histologic subtypes. The expression may correlate with the neoplastic differentiation and prognosis.
authors.affiliation: Department of Pathology, First Affiliated Hospital, Chengdu.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Cheng
mesh_terms: D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002675:Child, Preschool; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D005260:Female; D018197:Hepatoblastoma / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D008297:Male; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D002272:Carcinoembryonic Antigen; D019941:Cyclin-Dependent Kinase Inhibitor p16; D016159:Tumor Suppressor Protein p53