[Effects of flunarizine and vitamin C on hemodynamics in rat heart subjected to ischemia-reperfusion].
Langendorff perfusion isolated rat heart was subjected to total global ischemia (coronary flow rate is equal to zero) for 10 minutes and reperfusion for 15 minutes. The heart rate (HR), left ventricular developed pressure (LVDP), coronary flow rate (CFR), electrocardiogram (ECG) and the effects of calcium antagonist-flunarizine (FNZ) and/or oxygen free radical scavenger--vitamine C on the above parameters were observed. The results showed that FNZ dilated coronary vessel (P < 0.01) and had a slight negative chronotropic effect, but it had no effect on LVP. Vitamine C did not affect HR, LVP and CFR. The recovery of the product of HR and LVDP-Rate Pressure Product (RPP) in the FNZ + Vit. C group, Vit. C group and FNZ group was significantly higher than that in the control group (P < 0.05) at ten minutes reperfusion. All the results suggest that FNZ and Vit. C may improve the recovery of heart function after reperfusion.
Xian
Y
Y
Department of Physiology, School of Basic Medical Sciences, Chengdu.
Lan
T
T
Wang
Y
Y
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D005444:Flunarizine / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D066298:In Vitro Techniques; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar
D002121:Calcium Channel Blockers; D016166:Free Radical Scavengers; D001205:Ascorbic Acid; D005444:Flunarizine