5-HT1P receptor-mediated slow depolarization in neurons of guinea pig inferior mesenteric ganglion.
OBJECTIVE
To study the effects of several 5-hydroxytryptamine (5-HT) receptor subtype antagonists on 5-HT-induced depolarization and the effects of 5-HT1P receptor agonist on the membrane potential in the neurons of guinea pig inferior mesenteric ganglion (IMG).


METHODS
Intracellular recordings were made from neurons of the isolated guinea pig IMG.


RESULTS
Cyproheptadine (5-HT1/2 antagonist 10 mumol.L-1, n = 7) and BRL 24924 (5-HT1P antagonist 10 mumol.L-1, n = 19) reversibly suppressed 5-HT slow response; pressure ejection of MCPP (5-HT1P agonist 10 mmol.L-1) induced a slow depolarization in most of 5-HT sensitive neurons (10/14).


CONCLUSIONS
5-HT-induced slow depolarization is mediated by 5-HT1P receptor.
Wang
L C
LC
Department of Physiology, Anhui Medical University, Hefei, China.
Cai
S R
SR
Huang
Z X
ZX
Shao
Q L
QL
Ma
R C
RC
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D001549:Benzamides; D019086:Bridged Bicyclo Compounds, Heterocyclic; D006634:Histamine H1 Antagonists; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D003533:Cyproheptadine; D012701:Serotonin; C053006:renzapride