Effects of chlorpromazine or diltiazem given intraperitoneally alone or in combination on peritoneal transport of solute and water.
Calcium channel blocker given intraperitoneally (i.p.) in rats was reported to increase urea D/P ratio without protein loss. Chlorpromazine (CP) given i.p. in humans was reported to increase ultrafiltration (UF) and urea clearance. We studied the effects of i.p. Diltiazem (DZ) (15 mg/kg) and i.p. chlorpromazine (0.25 mg/L dialysate)--given alone or in combination--on urea D/P ratio, dialysate protein (Dpro), glucose concentration (Dg), UF, and drainage volume (Vd). Six male Sprague-Dawley rats were studied. The rats underwent 21 consecutive 30-minute exchanges with 15 mL of 1.5% of Dianeal solution (Baxter Healthcare Inc., Deerfield, Illinois, U.S.A.). DZ or CP was added to the dialysis solution during exchanges 4-6 and 10-12. During exchange 16-18 both DZ and CP were added to the dialysis solution. Exchanges 1-3, 7-9, 13-15, and 19-21 were control exchanges performed with 1.5% Dianeal solution alone. The mean weight of the rats was 541.6 +/- 44 g. The animals' blood pressure remained stable during the study period. An increase in D/Purea ratio was observed with DZ, with CP, and with the two drugs in combination, without increase in dialysate protein loss. An increase in UF with a decrease in D/D0 was observed with DZ, with CP, and with the two drugs in combination, suggesting a mechanism other than osmotic gradient--such as increased blood flow or decreased surface tension.
Thitiarchakul
S
S
Department of Medicine, Faculty of Medicine, Thammasat University, Prathumthani, Thailand.
Lal
S M
SM
Moore
H L
HL
Nolph
K D
KD
D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage* / Q000494:pharmacology; D003956:Dialysis; D004110:Diltiazem / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D010537:Peritoneum / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014462:Ultrafiltration; D014508:Urea / Q000378:metabolism; D014867:Water / Q000378:metabolism*
D014867:Water; D014508:Urea; D004110:Diltiazem; D002746:Chlorpromazine