title: Symptoms and signs reported during patch testing.
abstract: BACKGROUND
  In a pilot questionnaire study, there was a high frequency of subjective complaints and distant skin reactions during patch testing as reported at the day of test reading, particularly in female patients.
  
  
  OBJECTIVE
  To document in a controlled study possible side-effects of a generalized nature occurring during the test procedure.
  
  
  METHODS
  A questionnaire study on symptoms and signs reported at application and at reading of standard patch tests was conducted with 401 patients, with the patients serving as their own controls.
  
  
  RESULTS
  An eczematous flare-up during patch testing was observed in 3.7% of the patients. There were plenty of different symptoms of malaise but, with one exception (itch on the back), the number of symptoms tended to be less on the day of reading than on the day of application of the tests. This held true also for itch occurring in the patients' dermatitis. There was no statistical correlation between symptoms and signs on the one hand and positive patch tests on the other.
  
  
  CONCLUSIONS
  Distant skin reactions and impairment of general health occurring during patch testing are often reported at the time of test reading. However, with the exception of itch on the back, symptoms and signs are rather less common after the application of patch tests than before.
authors.affiliation: Department of Dermatology, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Inerot
authors.forename: H
authors.initials: H
authors.lastname: Möller
mesh_terms: D000328:Adult; D002648:Child; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D004485:Eczema / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests / Q000009:adverse effects*; D010865:Pilot Projects; D012737:Sex Factors; D011795:Surveys and Questionnaires; D013548:Sweden