Chronic intracerebroventricular infusion of beta-amyloid (1-40) results in a selective loss of neuropeptides in addition to a reduction in choline acetyltransferase activity in the cortical mantle and hippocampus in the rat.
Nag
S
S
Department of Physiology, Faculty of Medicine, University of Hong Kong, Peoples Republic of China.
Yee
B K
BK
Tang
F
F
D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007263:Infusions, Parenteral; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D009479:Neuropeptides / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016229:Amyloid beta-Peptides; D009479:Neuropeptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D002795:Choline O-Acetyltransferase