Parkinson's disease surgery: advances and future strategies.
The recent resurgence of surgical treatment of Parkinson's disease has generated enormous interest in the scientific community and with the general public. Both ablation (pallidotomy, thalamotomy), deep brain stimulation (thalamus, pallidum, subthalamus), and neural transplantation (human, porcine) have been demonstrated to be effective for specific subsets of Parkinson's disease patients. Future studies need to define better the ideal target sites and lesion volume of ablation and stimulation procedures, and optimising graft survival in neural transplantation. Numerous potential surgical interventions are currently being evaluated.
Tan
E K
EK
Department of Neurology, Singapore General Hospital, Singapore.
D016380:Brain Tissue Transplantation / Q000639:trends; D004599:Electric Stimulation Therapy / Q000639:trends; D016332:Fetal Tissue Transplantation / Q000639:trends; D005544:Forecasting; D006801:Humans; D010300:Parkinson Disease / Q000601:surgery*; D011612:Psychosurgery / Q000639:trends*