MSY2: a slowly evolving minisatellite on the human Y chromosome which provides a useful polymorphic marker in Chinese populations.
We present the second human Y-specific minisatellite, MSY2 (DYS440). It consists of three or four copies of a 99-110bp repeat unit and is located about 1kb upstream of the DBY gene. The most common allele contains four units, but a three-unit allele has arisen on at least four occasions; in chimpanzees and orangutans, MSY2 contains only two units. It is therefore evolving slowly and provides a particularly useful polymorphic marker for Chinese populations.
Bao
W
W
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK.
Zhu
S
S
Pandya
A
A
Zerjal
T
T
Xu
J
J
Shu
Q
Q
Du
R
R
Yang
H
H
Tyler-Smith
C
C
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002681:China; D004247:DNA / Q000737:chemistry / Q000235:genetics; D015342:DNA Probes; D005260:Female; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D008969:Molecular Sequence Data; D002679:Pan troglodytes / Q000235:genetics; D011110:Polymorphism, Genetic; D011148:Pongo pygmaeus / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014998:Y Chromosome / Q000235:genetics*
D015342:DNA Probes; D005819:Genetic Markers; D004247:DNA