Plasmacytoma of the breast. A report of two cases diagnosed by aspiration biopsy.
BACKGROUND
Extramedullary plasmacytoma of the breast is an uncommon neoplasm, occurring either as a solitary tumor or as evidence of disseminated multiple myeloma.


METHODS
Two cases of plasmacytoma of the breast were diagnosed by fine needle aspiration cytology. Aspiration smears showed a dispersed population of plasmacytoid cells with eccentric nuclei, abundant cytoplasm and the characteristic paranuclear hof.


CONCLUSIONS
The clinical, cytologic and immunophenotypic features of plasmacytoma are characteristic, and the importance of distinguishing these neoplasms from primary mammary tumors is important to avoid unnecessary surgery.
Cangiarella
J
J
Department of Pathology, New York University School of Medicine, New York, USA. joan.cangiarella@ccmail.med.nyu.edu
Waisman
J
J
Cohen
J M
JM
Chhieng
D
D
Symmans
W F
WF
Goldenberg
A
A
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000368:Aged; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000378:metabolism; D001707:Biopsy, Needle; D001940:Breast / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018567:Breast Neoplasms, Male / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase / Q000378:metabolism; D010954:Plasmacytoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*
D015703:Antigens, CD; D000943:Antigens, Differentiation; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D008562:Membrane Glycoproteins; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D009244:NAD+ Nucleosidase; D051997:ADP-ribosyl Cyclase 1