title: Interferon-alpha-associated development of bullous lesions in mycosis fungoides.
abstract: We report a 67-year-old woman with mycosis fungoides (MF) who was receiving subcutaneous injections of recombinant interferon alpha-2b (IFN-alpha). After 2 months of IFN-alpha treatment, bullous lesions appeared on her trunk and extremities. A skin biopsy specimen from the trunk revealed histopathologic features of bullous MF. Bullous lesions with specific infiltrates of MF are very rare; to the best of our knowledge, this is the first case showing specific bullous lesions of MF developed under IFN-alpha treatment.
authors.affiliation: Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pföhler
authors.forename: S
authors.initials: S
authors.lastname: Ugurel
authors.forename: S
authors.initials: S
authors.lastname: Seiter
authors.forename: A
authors.initials: A
authors.lastname: Wagner
authors.forename: W
authors.initials: W
authors.lastname: Tilgen
authors.forename: U
authors.initials: U
authors.lastname: Reinhold
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects* / Q000627:therapeutic use; D009182:Mycosis Fungoides / Q000188:drug therapy*; D011994:Recombinant Proteins; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D007370:Interferon Type I; D011994:Recombinant Proteins