[Comparison between selenomethionine and sodium selenite on action potentials of cultured myocardiocytes].
The action potentials of ventricular myocardial cells were recorded with glass microelectrodes inside the cells from neonatal Wistar rats treated with selenomethionine and sodium selenite in concentrations of 1.0, 2.0, and 4.0 mg/L selenium. Both of selenomethionine and sodium selenite decreased the action potential parameters, such as action potential amplitude(APA), overshoot(OS), threshold potential(TP), maximum diastolic potential (MDP) and maximum rate of depolarization (Vmax). Selenomethionine decreased the action potential duration at 10%, 50% and 90% repolarization (APD10, APD50 and APD90), while sodium selenite prolonged APD10, APD50 and APD90 at dose of 4.0 mg/L selenium and decreased APD50 and APD90 at dose of 1.0 and 2.0 mg/L selenium. The results indicated that both sodium selenite and selenomethionine inhibit the transmembrane movement of Ca2- and sodium selenite also inhibits transmembrane movement of K+.
Peng
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S
Beijing Institute of Pharmacology and Toxicology, China.
Liu
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D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D008297:Male; D008839:Microelectrodes; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar; D012645:Selenomethionine / Q000494:pharmacology*; D018038:Sodium Selenite / Q000494:pharmacology*
D012645:Selenomethionine; D018038:Sodium Selenite