[Statistically evaluated 95% prediction ranges as alternative to reference ranges exemplified by polychlorinated dibenzo-p-dioxins/dibenzofurans and lead].
Using the 95% prediction limits of an age-related multiplicative regression model describing the datasets of blood examinations carried out on subjects suspected of having been exposed to lead and to polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/F), it was shown that the relevant curves can be used as an alternative to reference ranges describing the actual background exposure to these pollutants. The upper limit of the actual German background exposure can be estimated by the following equations: PCDD/F as International Toxicity Equivalents in the age range of 10-70 years [pg/g lipid basis] = 1.64.age0.871 and lead in the age range of 15-80 years [microgram/l] = 18.15.age0.3638.
Wittsiepe
J
J
Abteilung für Hygiene, Sozial- und Umweltmedizin, Ruhr-Universität Bochum. wittsiepe@hygiene.ruhr-uni-bochum.de
Schrey
P
P
Flieger
A
A
Ewers
U
U
Wilhelm
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001572:Benzofurans / Q000097:blood*; D002648:Child; D004147:Dioxins / Q000097:blood*; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005858:Germany; D006801:Humans; D007854:Lead / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012016:Reference Values
D001572:Benzofurans; D004147:Dioxins; D004785:Environmental Pollutants; D007854:Lead; C023614:dibenzofuran; C020887:dibenzo(1,4)dioxin