[The expression of proliferating cell nuclear antigen and p53 protein in salivary gland tumours].
The expressions and distributions of PCNA and p53 protein were studied with anti-PCNA and anti-p53 protein MoAbs, using immunohistochemical staining method in salivary gland tumour. The relationship between PCNA and p53 protein was also studied. Results indicated: Malignant mixed tumour (MmT) had a higher proliferating index (PI) of PCNA. The PI could be used as one of adjuvant diagnostic criteria; and as an important parameter for grading mucoepidermoid carcinoma (MEC); The positive expression of p53 might be a good tumour marker for MmT; Tumour tissues with positive expression of p53 had been shown higher PI of PCNA, however there was no significance difference in our group; It remained to be studied later.
Tian
Y
Y
Affiliated Stomatologic Hospital of China Medical University, Shenyang.
Wang
Z
Z
Zhong
M
M
D008949:Adenoma, Pleomorphic / Q000378:metabolism; D014408:Biomarkers, Tumor; D018277:Carcinoma, Mucoepidermoid / Q000378:metabolism; D006801:Humans; D018198:Mixed Tumor, Malignant / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D012468:Salivary Gland Neoplasms / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53