Occurrence of serum M-protein species in Japanese patients older than 50 years based on relative mobility in cellulose acetate membrane electrophoresis.
We investigated the occurrence of serum M-protein species in 2,007 Japanese patients older than 50 years of age. All sera samples were analyzed by cellulose acetate membrane electrophoresis. The relative mobility of an M-protein band was calculated by dividing the migration distance of M protein by that of albumin. M proteins were found to be present in 71 of 2,007 cases (3.5%). Men 80-89 years old showed the highest occurrence of M proteins, 11.0%. The relative mobility of M-protein bands, especially the band of the IgA-type M protein, increased as the patient's age advanced. The patients had higher levels of the IgG-type M protein than healthy Japanese subjects. We found that the occurrence of M-protein species in Japanese patients increases with their age. The IgG-type M protein was most frequently expressed among other types. The mobility of the M protein was greater in older patients probably because of aging-related changes in the carbohydrate chain of immunoglobulins composing an M-protein molecule.
Kurihara
Y
Y
School of Allied Health Sciences, Faculty of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. yuriko.ando.mtec@med.tmd.ac.jp
Shiba
K
K
Fukumura
Y
Y
Kobayashi
I
I
Kamei
S
S
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D064211:Connectin; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood; D009124:Muscle Proteins; D009194:Myeloma Proteins / Q000032:analysis*; D009369:Neoplasms / Q000097:blood; D012016:Reference Values; D008258:Waldenstrom Macroglobulinemia / Q000097:blood
D064211:Connectin; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009124:Muscle Proteins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins