Fibrin glue reduces the severity of intra-abdominal adhesions in a rat model.
BACKGROUND
The purpose of this study was to determine whether fibrin glue inhibits intra-abdominal adhesions.


METHODS
Twenty rats underwent midline laparotomy. To maximize adhesions, bilateral peritoneal muscular defects were created and covered with polypropylene mesh sewn with a braided suture. The bowel was abraded with dry gauze. Rats were randomized to either fibrin glue (FG) sprayed over the mesh or to control (no further treatment) groups. At 1 week, the adhesion density (graded 0 to 3), the percentage of the patch covered by adhesion (0% to 100%), and adhesion type were recorded.


RESULTS
The mean adhesion density was 1.45+/-0.33 for FG versus 2.8+/-0.11 for controls (P = 0.001). The mean percentage of adhesions was 36+/-9.9 for the FG group and 94+/-3.7 for controls (P = 0.0002). Bowel or solid organs were adherent to the patch in 6 of 20 (30%) in the FG group versus 12 of 20 (70%) in controls (P = 0.057).


CONCLUSIONS
Topical fibrin glue reduces the density and severity of intra-abdominal adhesions in a rat model.
de Virgilio
C
C
Department of Surgery, Harbor-UCLA Medical Center, Torrance, California 90509, USA.
Elbassir
M
M
Hidalgo
A
A
Schaber
B
B
French
S
S
Amin
S
S
Stabile
B E
BE
D000818:Animals; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D007813:Laparotomy; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D000267:Tissue Adhesions / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000494:pharmacology*
D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives