title: Activation of SoxR by overproduction of desulfoferrodoxin: multiple ways to induce the soxRS regulon.
abstract: The soxRS response, which protects cells against superoxide toxicity, is triggered by the oxidation of SoxR, a transcription factor. Superoxide excess and NADPH depletion induce the regulon. Unexpectedly, we found that the overproduction of desulfoferrodoxin, a superoxide reductase from sulfate-reducing bacteria, also induced this response. We suggest that desulfoferrodoxin interferes with the reducing pathway that keeps SoxR in its inactive form.
authors.affiliation: Institut Jacques Monod, CNRS-Universités Paris 6 et Paris 7, 75251 Paris Cedex 05, France.
authors.forename: P
authors.initials: P
authors.lastname: Gaudu
authors.forename: S
authors.initials: S
authors.lastname: Dubrac
authors.forename: D
authors.initials: D
authors.lastname: Touati
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics; D029968:Escherichia coli Proteins; D005288:Ferredoxins / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D009249:NADP / Q000378:metabolism; D010957:Plasmids / Q000235:genetics; D018085:Regulon; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D005288:Ferredoxins; D015534:Trans-Activators; D014157:Transcription Factors; C066602:desulfoferrodoxin; D013481:Superoxides; C070724:SoxR protein, Bacteria; C070725:SoxS protein, E coli; D009249:NADP; D013482:Superoxide Dismutase