Bi-directional signal transduction by integrin receptors.
The integrin family of cell surface glycoproteins functions primarily as receptors for extracellular matrix ligands. There are now many well characterized integrin-ligand interactions which are known to influence many aspects of cell behaviour including cell morphology, cell adhesion, cell migration as well as cellular proliferation and differentiation. However, in fulfilling these functions, integrins are not simple adhesion receptors that physically mediate connections across the plasma membrane. Rather, integrin function itself is highly regulated, largely through the formation of specific associations with both structural and regulatory components within cells. It is these intracellular interactions which allow integrin function to effect many biochemical signalling pathways and therefore to impinge upon complex cellular activities. Recently, much research has focused on elucidating the molecular mechanisms which control integrin function and the molecular processes which transduce integrin-mediated signalling events. In this review, we discuss progress in the field of integrin signal transduction including, where applicable, potential therapeutic applications arising from the research.
Coppolino
M G
MG
Division of Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Dedhar
S
S
D000818:Animals; D002135:Calcium-Binding Proteins / Q000502:physiology; D037282:Calreticulin; D002352:Carrier Proteins / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D016023:Integrins / Q000502:physiology*; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D012261:Ribonucleoproteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D000099200:Scaffold Protein ILK
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D016023:Integrins; D020928:Mitogen-Activated Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D012261:Ribonucleoproteins; D000099200:Scaffold Protein ILK; C109198:CIB1 protein, human; C496050:PTK2 protein, human