title: Cortical reorganization after acute unilateral hearing loss traced by fMRI.
abstract: Unilateral acoustic stimulation produces a functional MRI (fMRI)-blood-oxygenation-level-dependent (BOLD) response mainly in the contralateral auditory cortex. In unilateral deaf patients, the BOLD response is bilateral. We studied a subject with sudden hearing loss after cochlear nerve resection before and repeatedly after surgery. During normal bilateral hearing, contralateral cortical BOLD responses were found. Progressing compensatory reorganization with bilateral representation of unilateral stimulation was detected over a period of approximately 1 year.
authors.affiliation: Department of Radiology, University of Basel, Switzerland.
authors.forename: D
authors.initials: D
authors.lastname: Bilecen
authors.forename: E
authors.initials: E
authors.lastname: Seifritz
authors.forename: E W
authors.initials: EW
authors.lastname: Radü
authors.forename: N
authors.initials: N
authors.lastname: Schmid
authors.forename: S
authors.initials: S
authors.lastname: Wetzel
authors.forename: R
authors.initials: R
authors.lastname: Probst
authors.forename: K
authors.initials: K
authors.lastname: Scheffler
mesh_terms: D000208:Acute Disease; D001301:Audiometry, Pure-Tone; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003638:Deafness / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged