title: Early occlusion of coronary by-pass associated with the presence of factor V Leiden and the prothrombin 20210A allele: case report.
abstract: The presence of factor V Leiden mutation and the variation of the prothrombin gene 20210GA have been described as additional risk factors for arterial thrombosis when other acquired or metabolic risk factors are present. We report here a 56-year-old man who developed coronary artery disease since 1980 without any known risk factor and underwent a cardiopulmonary by-pass in 1997. In the first month after surgery, he became symptomatic, and an angiography showed complete occlusion of the grafts and some native coronary arteries. Three months after the second cardiopulmonary by-pass, a thrombophilic state was searched, and plasma levels of lipoprotein (a) (LPa) were measured. The patient is heterozygous for factor V Leiden mutation and has the variation 20210GA of the prothrombin gene and high levels of LPa. These findings induced us to add oral anticoagulation to the aspirin treatment, and the patient is in a good condition 11 months later.
authors.affiliation: Favaloro University, Institute of Cardiology and Cardiovascular Surgery, Division of Hematology, Buenos Aires, Argentina.
authors.forename: M L
authors.initials: ML
authors.lastname: Varela
authors.forename: Y P
authors.initials: YP
authors.lastname: Adamczuk
authors.forename: M E
authors.initials: ME
authors.lastname: Martinuzzo
authors.forename: R R
authors.initials: RR
authors.lastname: Forastiero
authors.forename: F R
authors.initials: FR
authors.lastname: Klein
authors.forename: A S
authors.initials: AS
authors.lastname: Rossi
authors.forename: L O
authors.initials: LO
authors.lastname: Carreras
mesh_terms: D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000235:genetics / Q000503:physiopathology / Q000601:surgery; D005165:Factor V / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D011516:Prothrombin / Q000235:genetics*; D012008:Recurrence; D013927:Thrombosis / Q000235:genetics / Q000503:physiopathology
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin