title: Serial positron emission tomography (PET) in gliomatosis cerebri treated with radiotherapy: a case report.
abstract: Results of serial positron emission tomography (PET) in a biopsy-proven case of gliomatosis cerebri (GC) are reported. Computed tomography (CT) with and without contrast failed to detect focal abnormalities, but magnetic resonance (MR) revealed iso-intensity or low-intensity lesions in T1-weighted images and high-intensity lesions in T2-weighted images. Lesions were seen in the left thalamus, right temporal lobe and claustrum, and pons. Radiotherapy remarkably improved clinical and imaging findings. Both before and shortly after radiotherapy, 11C-methionine PET images showed hypermetabolism while 15O-water PET images showed a marked increase in cerebral blood flow in GC lesions. However, 6 months later PET images had remarkably improved, appearing nearly normal.
authors.affiliation: Department of Neurology, Toride Kyodo General Hospital, 2-1-1 Hongoh, Toride City, Ibaraki, Japan. dw4s-sntn@asahi-net.or.jp
authors.forename: S
authors.initials: S
authors.lastname: Shintani
authors.forename: S
authors.initials: S
authors.lastname: Tsuruoka
authors.forename: T
authors.initials: T
authors.lastname: Shiigai
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D014055:Tomography, Emission-Computed