Evaluation of oxidative stress before and after control of glycemia and after vitamin E supplementation in diabetic patients.
The present study evaluates the presence of oxidative stress in the uncontrolled diabetic state. Glycemic control reduced the oxidative stress, but total normalization of the parameters of oxidative stress was not achieved, indicating continued oxidant injury despite optimal control of the diabetes. Vitamin E supplementation for 4 weeks in these patients further reduced the oxidative stress, suggesting that vitamin E supplementation might be helpful in reducing free-radical-induced oxidant injury.
Sharma
A
A
Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Kharb
S
S
Chugh
S N
SN
Kakkar
R
R
Singh
G P
GP
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy; D005260:Female; D005913:Glipizide / Q000627:therapeutic use; D005978:Glutathione / Q000097:blood; D005905:Glyburide / Q000627:therapeutic use; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D005978:Glutathione; D005905:Glyburide; D005913:Glipizide