Combinatorial protein reagents to manipulate protein function.
The design and use of combinatorial protein libraries has become a fast moving field in molecular biology. Different experimental systems supporting various selection schemes are now available. The latest breakthroughs include evolutionary experiments to improve existing binding surfaces, selections of homodimerizing peptides, the use of peptide aptamers to disrupt protein interactions inside living cells, and functional selections of aptamers to probe regulatory networks.
Colas
P
P
Laboratoire de Biologie Moléculaire et Cellulaire, Ecole Normale Supérieure, Lyon, 69364, France. Pierre.Colas@ens-lyon.fr.
D020650:Combinatorial Chemistry Techniques; D019143:Evolution, Molecular; D007202:Indicators and Reagents / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
D007202:Indicators and Reagents; D011506:Proteins