[Antagonistic action of organic selenium on lead poisoning].
Ninety white rats were treated with liquid lead acetate. When the concentration of lead in urine was more than (0.81 +/- 0.26) mg/L and blood lead was more than (4.8 +/- 0.33) mg/L, the rats were divided into three groups randomly. The oxygenic damage indicators in serum showed SOD activity decreased and MDA content increased. In one group of lead rats fed with an organic selenium compound (code FCQY) the SOD activities were high and the lipid peroxidation was inhibited compared with controls without selenium supplementation. The lead contents of bone, kidney and liver were measured. The results suggested that the organic selenium compound could interfere with the absorption and accumulation of lead.
He
B
B
Qingdao Public Health and Anti-epidemic Station, China.
Xu
Z
Z
Hao
W
W
Wang
S
S
D000818:Animals; D005260:Female; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D018036:Selenium Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D013482:Superoxide Dismutase / Q000097:blood*
D018036:Selenium Compounds; D007854:Lead; D008315:Malondialdehyde; D013482:Superoxide Dismutase