title: A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
authors.affiliation: SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex CM19 5AW, U.K. Peter_J_Lovell@sbphrd.com
authors.forename: P J
authors.initials: PJ
authors.lastname: Lovell
authors.forename: S M
authors.initials: SM
authors.lastname: Bromidge
authors.forename: S
authors.initials: S
authors.lastname: Dabbs
authors.forename: D M
authors.initials: DM
authors.lastname: Duckworth
authors.forename: I T
authors.initials: IT
authors.lastname: Forbes
authors.forename: A J
authors.initials: AJ
authors.lastname: Jennings
authors.forename: F D
authors.initials: FD
authors.lastname: King
authors.forename: D N
authors.initials: DN
authors.lastname: Middlemiss
authors.forename: S K
authors.initials: SK
authors.lastname: Rahman
authors.forename: D V
authors.initials: DV
authors.lastname: Saunders
authors.forename: L L
authors.initials: LL
authors.lastname: Collin
authors.forename: J J
authors.initials: JJ
authors.lastname: Hagan
authors.forename: G J
authors.initials: GJ
authors.lastname: Riley
authors.forename: D R
authors.initials: DR
authors.lastname: Thomas
mesh_terms: D002460:Cell Line; D006801:Humans; D008958:Models, Molecular; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D010636:Phenols; D011985:Receptors, Serotonin; D011994:Recombinant Proteins; C404922:SB 269970; D012702:Serotonin Antagonists; D013449:Sulfonamides; C104425:serotonin 7 receptor