[The effect of anisodaminum and dexamethasone on microcirculation, TNF, LPO and pathology in MODS].
In order to evaluate the effect of anisodaminum and dexamethasone to the microcurculation, TNF, LPO and pathology in MODS, we first established MODS model using cecem ligature and perfuration of rabbit then divided it into four groups: anisodaminum, dexamethasone, combined anisodaminum and dexamethasone and control. After used the corresponding drugs we observed the change of microcirculation, TNF, LPO and organ pathology. The result showed that microcirculation improved, the serum level of TNF and LPO decreased, and the pathomorphological changes lessensed. It is suggested that the combined use of anisodaminum and dexamethasone may be a new way for treating MODS.
Yue
M
M
Department of General Surgery, General Hospital, Commission of Science, Technology and Industry for National Defense of the People's Republic of China, Beijing.
Li
C
C
Zhao
E
E
Li
X
X
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology; D008054:Lipid Peroxides / Q000097:blood*; D008168:Lung / Q000473:pathology; D008833:Microcirculation / Q000187:drug effects; D009102:Multiple Organ Failure / Q000378:metabolism* / Q000473:pathology; D011817:Rabbits; D012991:Solanaceous Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D012991:Solanaceous Alkaloids; D014409:Tumor Necrosis Factor-alpha; C003922:anisodamine; D003907:Dexamethasone