title: Acute renal artery and vein thrombosis after renal transplant, associated with a short partial thromboplastin time and factor V Leiden mutation.
abstract: Renal graft thrombosis is a rare but devastating complication of renal transplantation. It accounts for one-third to one-half of early graft losses. We report a patient with acute renal artery and vein thrombosis associated with abnormally short activated partial thromboplastin time (aPTT) and factor V Leiden mutation. Vascular thrombosis developed on the ninth post-transplant day and led to a graft loss. Before transplantation, the patient had three episodes of thrombosis of arteriovenous access for hemodialysis. Our case illustrates the importance of investigating pretransplant patients for hypercoagulable states, particularly those with short aPTT.
authors.affiliation: Department of Medicine, Medical University of South Carolina, Charleston 29525, USA.
authors.forename: N
authors.initials: N
authors.lastname: Guirguis
authors.forename: M N
authors.initials: MN
authors.lastname: Budisavljevic
authors.forename: S
authors.initials: S
authors.lastname: Self
authors.forename: P R
authors.initials: PR
authors.lastname: Rajagopalan
authors.forename: J
authors.initials: J
authors.lastname: Lazarchick
mesh_terms: D000208:Acute Disease; D000328:Adult; D005165:Factor V / Q000235:genetics*; D005260:Female; D006085:Graft Survival / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation; D009154:Mutation; D010314:Partial Thromboplastin Time; D011237:Predictive Value of Tests; D012077:Renal Artery / Q000503:physiopathology; D012078:Renal Artery Obstruction / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D012082:Renal Veins / Q000503:physiopathology; D017211:Treatment Failure; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology
chemical_list: C095381:factor V Leiden; D005165:Factor V