[The inhibitory effect of hydroprednisolone on tumor necrosis factor in rabbits' temporomandibular joint disturbance syndrome].
In order to study the mechanism of hydroprednisolone for temporomandibular joint disturbance syndrome (TMJDS), 12 white rabbits were injected TNF into the rabbits' right TMJDS for 2 to 3 times, 90,000 u each time, then another drug, 2 mg hydroprednisolone, was injected into these TMJDS again. The rabbits were killed after 8 to 18 days and the TMJDS were examined by microscope. We found the articular tissues only destroyed slightly and sometimes the cartilages were nearly normal. So, the study suggested that hydroprednisolone can reduce the destruction of TNF on rabbit's TMJ obviously. This may be the cause why hydroprednisolone is useful to TMJDS.
Gu
Z
Z
Department of Stomatology, First Teaching Hospital, Zhejiang Medical University, Hangzhou.
Cao
Z
Z
Fang
Y
Y
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D008297:Male; D011239:Prednisolone / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D013704:Temporomandibular Joint / Q000473:pathology*; D013706:Temporomandibular Joint Dysfunction Syndrome / Q000188:drug therapy / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha; D011239:Prednisolone