Influence of insulin resistance on total renin level in normotensive women with polycystic ovary syndrome.
OBJECTIVE
To evaluate the influence of insulin resistance on the plasma total renin level in normotensive women with polycystic ovary syndrome (PCOS).


METHODS
Prospective, controlled study.


METHODS
University hospital.


METHODS
Twenty-five normotensive women with PCOS were compared with 11 normotensive control women with regular cycles and no features of PCOS.


METHODS
Clinical, ultrasonographic, and hormonal findings were used to define PCOS. Insulin resistance was estimated by continuous infusion of glucose with model assessment in the early follicular phase.


METHODS
Plasma levels of total renin and angiotensin II and serum levels of gonadotropins, DHEAS, total T, free T, 17 alpha-hydroxyprogesterone, and PRL were determined.


RESULTS
Plasma concentrations of angiotensin II were similar in the PCOS group and the control group. The concentration of total renin in plasma was higher in women with PCOS than in healthy women independent of insulin resistance. The sensitivity and specificity of the plasma total renin level to diagnose women with PCOS were calculated as 80% and 71.4%, respectively.


CONCLUSIONS
The plasma total renin level is higher in normotensive women with PCOS than in healthy women independent of insulin resistance.
Hacihanefioglu
B
B
Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty and Experimental Medicine and Research Center, Istanbul University, Turkey. hburak@escortnet.com
Seyisoglu
H
H
Karsidag
K
K
Elter
K
K
Aksu
F
F
Yilmaz
T
T
Gurol
A O
AO
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D011446:Prospective Studies; D012016:Reference Values; D012083:Renin / Q000097:blood*
D006728:Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D012083:Renin