New approaches for cell-specific targeting: identification of cell-selective peptides from combinatorial libraries.
Peptides that recognize specific cell types promise to be valuable tools both in research and clinical applications. Cell-specific peptides can be useful as drug delivery vehicles, diagnostic agents, affinity reagents for cell purification, gene therapy delivery agents, and research tools to probe the nature of a cell's surface. Recently, cell-specific targeting-peptides have been identified by phage-display selections against purified cell-surface markers, whole cells in tissue culture, and even tissues within live animals. These methods for identifying cell-targeting peptides will certainly increase the tools available to the scientist for cell-specific targeting.
Brown
K C
KC
Department of Internal Medicine, Center for Biomedical Inventions, University of Texas, Southwestern Medical Center, Dallas, TX 75390-8573, USA. brown@ryburn.swmed.edu.
D000818:Animals; D001435:Bacteriophages / Q000235:genetics; D020650:Combinatorial Chemistry Techniques; D009928:Organ Specificity; D019151:Peptide Library; D011956:Receptors, Cell Surface / Q000737:chemistry
D019151:Peptide Library; D011956:Receptors, Cell Surface