Association of HLA-DRB1 alleles with giant cell tumour of bone.
OBJECTIVE
To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone.


METHODS
HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours.


RESULTS
Five of the eight patients were found to be positive for HLA-DRB1*0801/3, the distribution of this allele in healthy white controls being quite low (2%). All but one of the patients possessing DRB1*080 also expressed DRB1*070.


CONCLUSIONS
HLA-DRB1*080 is pre-dominant in patients with immunophenotypic HLA-DR negative giant cell tumour of bone; individuals with the genotype 070/080 are at particularly high risk of developing giant cell tumour of bone.
Varanasi
S S
SS
Department of Clinical Biochemistry, Medical School, University of Newcastle, Newcastle upon Tyne, UK.
Athanasou
N A
NA
Briceno
I
I
Papiha
S S
SS
Datta
H K
HK
D000483:Alleles; D001859:Bone Neoplasms / Q000276:immunology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D018212:Giant Cell Tumor of Bone / Q000276:immunology*; D006684:HLA-DR Antigens / Q000032:analysis*; D059811:HLA-DRB1 Chains; D006801:Humans; D016133:Polymerase Chain Reaction
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains