Infrared scanning laser tomography of macular cysts.
OBJECTIVE
To perform three-dimensional, noninvasive, quantitative analysis of cystoid macular edema and macular cysts using infrared scanning laser tomography and to correlate findings with visual acuity (VA) as a basis for interventional studies.


METHODS
Cross-sectional, nonrandomized study.


METHODS
Seventeen patients (29-86 years of age) with macular cysts associated with a broad spectrum of diseases.


METHODS
Confocal infrared imaging with scanning laser tomography with the TopSS (790 nm) (Laser Diagnostic Technologies, San Diego, CA) with digitized images was used to perform three-dimensional, quantitative analysis of cysts in the central 5 degrees of the macula.


METHODS
Measurements of macular cyst number, area, volume, depth, slope, height of the surrounding macular elevation, and correlation with VA.


RESULTS
Scanning laser tomography detected macular cysts in all patients. The number per patient ranged from 1 through 15. Cysts were accompanied by surrounding macular elevation in 16 patients (mean macular height, 216 microm). The area covered by cysts in the central 5 degrees was 0.087 to 0.969 mm2, and volume was 0.007 to 0.549 mm3. Visual acuity was significantly poorer in patients with greater cyst area (P = 0.0007), cyst volume (P = 0.0009), macular thickening (P = 0.0002), and cyst depth (P = 0.0013). Cyst number, average slope, and maximum slope, however, did not correlate significantly with VA. Grouping of macular cysts according to macular height and average cyst depth revealed that cysts in a more thickened retina were significantly deeper, had steeper slopes, and corresponded to worse VA. Macular height and average cyst depth were highly associated with each other, suggesting that in eyes with surrounding macular edema, cysts were deeper and may reflect more widespread tissue destruction. Individual confocal tomographic images provided additional information. Neither ophthalmoscopy nor fluorescein angiography delineated features such as retinal folds that suggested vitreous traction or changes in deeper layers that suggested occult choroidal new vessels.


CONCLUSIONS
Infrared scanning laser tomography is a rapid and noninvasive imaging method that provides quantitative analysis of macular cysts in addition to qualitative information not seen clinically. Because poor VA is related to severe involvement of the central retina, scanning laser tomography could provide an objective outcome measure for interventional studies.
Beausencourt
E
E
Schepens Eye Research Institute, Boston, Massachusetts 02114-2500, USA.
Remky
A
A
Elsner
A E
AE
Hartnett
M E
ME
Trempe
C L
CL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007259:Infrared Rays; D007834:Lasers; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis*; D008875:Middle Aged; D012815:Signal Processing, Computer-Assisted; D014054:Tomography / Q000379:methods*; D014792:Visual Acuity