title: From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility.
abstract: The Abl tyrosine kinase plays an important role in axonogenesis. Recent reports indicate that this role involves interaction with several different protein families, including LAR phosphatases, catenin/cadherin cell adhesion complexes, Trio family GEFs, and Ena/VASP family actin regulatory proteins. These findings suggest that Abl and its associated proteins may regulate cell adhesion and actin polymerization, thereby regulating growth cone motility during axonogenesis.
authors.affiliation: Biology Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Imlanier@mit.edu
authors.forename: L M
authors.initials: LM
authors.lastname: Lanier
authors.forename: F B
authors.initials: FB
authors.lastname: Gertler
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002465:Cell Movement; D003599:Cytoskeleton / Q000378:metabolism; D029721:Drosophila Proteins; D020439:Growth Cones / Q000201:enzymology* / Q000502:physiology*; D010766:Phosphorylation; D011485:Protein Binding; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D016315:Proto-Oncogene Proteins c-abl / Q000378:metabolism*; D054557:Receptor-Like Protein Tyrosine Phosphatases; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000199:Actins; D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D016315:Proto-Oncogene Proteins c-abl; C117978:Lar protein, Drosophila; D017027:Protein Tyrosine Phosphatases; D054557:Receptor-Like Protein Tyrosine Phosphatases; D020741:rho GTP-Binding Proteins