[Efficacy of beta-carotene on lipid peroxidation induced by N-nitrosodimethylamine in rats].
The effect of beta-carotene (beta-C) on lipid peroxidation induced by N-nitrosodimethylamine (NDMN) in rats was studied. Thirty clear conventional SD rats were randomly devided into 3 groups and were intragastricly given daily water (10 ml/kg). NDMN (1.75 mg/kg), and NDMN (1.75 mg/kg) plus beta-C (25 mg/kg) respectively. The results showed that: compared with group 1, the activities of SOD and GSH-Px in NDMN group were significantly decreased (P < 0.05), the values of MDA and ROOH increased (P < 0.05). The activities of SOD and GSH-Px in group 3 were significantly higher and the contents of ROOH and MDA were significantly lower than that of NDMN group (P < 0.05). These results suggested that free radicals and lipid peroxidation may be a carcinogenic path for NDMN and other nitrosamines. beta-C had ability to inhibit the lipid peroxidation induced by NDMN.
Chen
Q
Q
School of Public Health, Sun Yat-sen University of Medical Sciences, Guangzhou, China.
Wang
S
S
Mei
J
J
Xu
Y
Y
D000818:Animals; D004128:Dimethylnitrosamine; D005979:Glutathione Peroxidase / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000097:blood; D019207:beta Carotene / Q000494:pharmacology*
D019207:beta Carotene; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D004128:Dimethylnitrosamine