Antimycobacterial activity of new ortho-, meta- and para-toluidine derivatives.
Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives.
Biava
M
M
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università La Sapienza, Rome, Italy. biava@axrma.uniroma1.it
Fioravanti
R
R
Porretta
G C
GC
Sleiter
G
G
Deidda
D
D
Lampis
G
G
Pompei
R
R
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D013045:Species Specificity; D013055:Spectrophotometry, Infrared; D014052:Toluidines / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells
D000900:Anti-Bacterial Agents; D014052:Toluidines