[Influence of MP infection on immunologic function in patients with chronic obstructive pulmonary disease].
The aim of this study was to detect Mycoplasma pneumoniae(MP) in sputum with chronic obstructive pulmonary disease(COPD) by using polymerase chain reaction and measured the level of sIL-2R in chronic pulmonary heart disease(CPHD) patients by Enzyme Linked Immnosorbert Assay(ELISA). At the same time, we also measured the level of the serum total IgE in CPHD patients. We determine the relationship between the sIL-2R and lymphocytes. The results showed that rate of MP infection in COPD patients was 34.59%. The rate of MP infection in CPHD patients and asthmatic patients were significantly higher than that in patients with chronic bronchitis. The level of sIL-2R in patients with CPHD who had MP infection increased significantly higher than that in CPHD patients which didn't have MP infection. There was a linear negative correlation between the level of sIL-2R and lymphocytes. The level of serum total IgE in CPHD patients with MP infection was higher than that in patients with other infection. These data suggest that MP is a common agent in COPD patients, particularly in CPHD and asthma. MP infection can impair the cellular immunity and immunotherapy combined with antibiotics may be more effective.
Yin
D
D
Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Yin
B
B
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008173:Lung Diseases, Obstructive / Q000276:immunology / Q000382:microbiology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011019:Pneumonia, Mycoplasma / Q000276:immunology*; D016133:Polymerase Chain Reaction; D011660:Pulmonary Heart Disease / Q000209:etiology / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000097:blood*
D015375:Receptors, Interleukin-2; D007073:Immunoglobulin E