title: [Levels of proinflammatory cytokines: IL-1, IL-6, IL-8, TNF-alpha and receptor IL-6R in Lyme borreliosis].
abstract: We estimated serum concentrations of cytokines IL-1, IL-6, IL-8, TNF-alfa and IL-6R of patients with diagnosed Lyme disease treated with beta-lactam antibiotics. Detection of proinflammatory cytokines was performed in ELISA tests. The examination was performed before and after treatment. Comparison with control group stated statistically significant higher concentration of IL-1 and IL-6 before and after treatment. There were no differences in concentration of TNF-alfa, IL-8 and IL-6R. Comparing concentrations of cytokines before and after treatment there was no differences either. Lack of changes in concentration of proinflammatory cytokines during beta-lactam therapy could be explained by too short period of therapy or immunologic background of inflammatory process in Lyme disease which was only initiated by spirochete Borrelia burgdorferi.
authors.affiliation: Kliniki Chorób Pasozytniczych i Neuroinfekcji AM w Białymstoku.
authors.forename: M
authors.initials: M
authors.lastname: Kondrusik
authors.forename: R
authors.initials: R
authors.lastname: Swierzbińska
authors.forename: J M
authors.initials: JM
authors.lastname: Zajkowska
authors.forename: S A
authors.initials: SA
authors.lastname: Pancewicz
authors.forename: T
authors.initials: T
authors.lastname: Hermanowska-Szpakowicz
mesh_terms: D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D008193:Lyme Disease / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016209:Interleukin-8; D019947:Receptors, Interleukin-6; D014409:Tumor Necrosis Factor-alpha