[An angiogenesis study of Dukes' B colonic tumors].
OBJECTIVE
To evaluate the angiogenesis in Dukes' B colon cancer.


METHODS
In 60 patients (age, 39-75 years), the microvessel density and the relationship between the angiogenesis and other histologic features were retrospectively evaluated. In an ongoing prospective study, 25 patients have been enrolled to determine the possible therapeutic implications of VEGF quantitative analysis.


RESULTS
The retrospective portion of this study confirms the prognostic value of the angiogenesis in terms of recurrences and survival. At present, no conclusions can be drawn from the prospective portion of the study.
Pantalone
D
D
Istituto di Clinica Chirurgica Generale e D.C.,Università degli Studi di Firenze, Italia.
Ziche
M
M
Messerini
L
L
Pazzagli
M
M
Morbidelli
L
L
Parenti
A
A
Donnini
S
S
Palomba
A R
AR
Tricarico
C
C
Paolucci
R
R
Taruffi
F
F
Andreoli
F
F
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D003106:Colon / Q000737:chemistry; D003110:Colonic Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology*; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D020033:Protein Isoforms / Q000032:analysis; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D014408:Biomarkers, Tumor; D016228:Endothelial Growth Factors; D008222:Lymphokines; D020033:Protein Isoforms; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors