title: Influence of insulin resistance on total renin level in normotensive women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate the influence of insulin resistance on the plasma total renin level in normotensive women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective, controlled study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Twenty-five normotensive women with PCOS were compared with 11 normotensive control women with regular cycles and no features of PCOS.
  
  
  METHODS
  Clinical, ultrasonographic, and hormonal findings were used to define PCOS. Insulin resistance was estimated by continuous infusion of glucose with model assessment in the early follicular phase.
  
  
  METHODS
  Plasma levels of total renin and angiotensin II and serum levels of gonadotropins, DHEAS, total T, free T, 17 alpha-hydroxyprogesterone, and PRL were determined.
  
  
  RESULTS
  Plasma concentrations of angiotensin II were similar in the PCOS group and the control group. The concentration of total renin in plasma was higher in women with PCOS than in healthy women independent of insulin resistance. The sensitivity and specificity of the plasma total renin level to diagnose women with PCOS were calculated as 80% and 71.4%, respectively.
  
  
  CONCLUSIONS
  The plasma total renin level is higher in normotensive women with PCOS than in healthy women independent of insulin resistance.
authors.affiliation: Department of Obstetrics and Gynecology, Cerrahpasa Medical Faculty and Experimental Medicine and Research Center, Istanbul University, Turkey. hburak@escortnet.com
authors.forename: B
authors.initials: B
authors.lastname: Hacihanefioglu
authors.forename: H
authors.initials: H
authors.lastname: Seyisoglu
authors.forename: K
authors.initials: K
authors.lastname: Karsidag
authors.forename: K
authors.initials: K
authors.lastname: Elter
authors.forename: F
authors.initials: F
authors.lastname: Aksu
authors.forename: T
authors.initials: T
authors.lastname: Yilmaz
authors.forename: A O
authors.initials: AO
authors.lastname: Gurol
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000503:physiopathology*; D011446:Prospective Studies; D012016:Reference Values; D012083:Renin / Q000097:blood*
chemical_list: D006728:Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D012083:Renin