title: Biological UV dosimeters in the assessment of the biological hazard from environmental radiation.
abstract: To determine the impact of environmental UV radiation, biological dosimeters that weight directly the incident UV components of sunlight have been developed, improved and evaluated in the frame of the BIODOS project. Four DNA-based biological dosimeters ((i) phage T7, (ii) uracil thin layer, (iii) spore dosimeter and (iv) DLR-biofilm) have been assessed from the viewpoint of their biological relevance, spectral response and quantification of their biological effectiveness. The biological dosimeters have been validated by comparing their readings with weighted spectroradiometer data, by comparison with other biological doses, as well as with the determined amounts of DNA UV photoproducts. The data presented here demonstrate that the biological dosimeters are potentially reliable field dosimeters for measuring the integrated biologically effective irradiance for DNA damage.
authors.affiliation: Institute of Biophysics and Radiation Biology, Semmelweis University of Medicine, Budapest, Hungary. berces@puskin.sote.hu
authors.forename: A
authors.initials: A
authors.lastname: Bérces
authors.forename: A
authors.initials: A
authors.lastname: Fekete
authors.forename: S
authors.initials: S
authors.lastname: Gáspár
authors.forename: P
authors.initials: P
authors.lastname: Gróf
authors.forename: P
authors.initials: P
authors.lastname: Rettberg
authors.forename: G
authors.initials: G
authors.lastname: Horneck
authors.forename: G
authors.initials: G
authors.lastname: Rontó
mesh_terms: D001412:Bacillus subtilis / Q000528:radiation effects; D017123:Bacteriophage T7 / Q000528:radiation effects; D018441:Biofilms / Q000528:radiation effects; D004249:DNA Damage / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D011874:Radiometry; D013171:Spores, Bacterial / Q000187:drug effects; D013472:Sunlight; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014498:Uracil / Q000528:radiation effects
chemical_list: D014498:Uracil