Bacterial pili: molecular mechanisms of pathogenesis.
Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.
Sauer
F G
FG
Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Mulvey
M A
MA
Schilling
J D
JD
Martinez
J J
JJ
Hultgren
S J
SJ
D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism / Q000472:pathogenicity* / Q000648:ultrastructure; D004927:Escherichia coli Infections / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism; D014552:Urinary Tract Infections / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology
D001426:Bacterial Proteins; D016207:Cytokines; D018832:Molecular Chaperones