Histone deacetylases: silencers for hire.
Over the past few years, the long-standing idea that covalent modification of chromatin can play a role in determining states of gene activity has been confirmed. Eukaryotic genes can be silenced by deacetylation of acetyl-lysine moieties in the N-terminal tails of histones. Recent work links histone deacetylases with an increasing number of repressors, suggesting that deacetylation might be a rather pervasive feature of transcriptional repression systems.
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Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, Edinburgh, UK EH9 3JR.
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D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D020868:Gene Silencing; D006655:Histone Deacetylases / Q000502:physiology*; D006801:Humans; D051740:Ikaros Transcription Factor; D009687:Nuclear Proteins / Q000378:metabolism; D056971:Nuclear Receptor Co-Repressor 1; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D051900:Smad3 Protein; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C497239:IKZF1 protein, human; C106285:IKZF3 protein, human; C539127:NCOR1 protein, human; D009687:Nuclear Proteins; D056971:Nuclear Receptor Co-Repressor 1; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; C071731:SIN3 protein, S cerevisiae; C497790:SMAD3 protein, human; D029701:Saccharomyces cerevisiae Proteins; D051900:Smad3 Protein; D015534:Trans-Activators; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C060614:SKI protein, human; D051740:Ikaros Transcription Factor; C120917:MTA2 protein, human; D006655:Histone Deacetylases