title: Dose findings of dihydroartemisinin in treatment of falciparum malaria.
abstract: Forty patients with uncomplicated P. falciparum malaria were respectively treated in an open randomized comparative study of dihydroartemisinin tablets given at total doses of 480 mg over 5 days and 640 mg over 7 days in a drug-resistant malaria endemic area in Hainan, China. The result showed that all patients were clinically cured. In 5-day and 7-day groups, the mean fever clearance times (FCT) were 26.1+/-10.2 and 21.1+/-11.8 hours respectively; the mean parasite clearance times (PCT) were 58.7+/-20.9 and 59.4+/-20.9 hours respectively, which showed no significant difference. 28-day follow-ups were accomplished on 39 and 37 cases respectively in two groups, the recrudescence rates were 20.5% (8/39) in 5-day group, while 2.7% (1/37) in 7-day group with significant difference (chi2=4.19, p<0.05). No clinical drug-related side effect was found in two groups during treatment.
authors.affiliation: Tropical Medicine Institute, Guangzhou University of Traditional Chinese Medicine, PR China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Li
authors.forename: X H
authors.initials: XH
authors.lastname: Wang
authors.forename: X B
authors.initials: XB
authors.lastname: Guo
authors.forename: L C
authors.initials: LC
authors.lastname: Fu
authors.forename: H X
authors.initials: HX
authors.lastname: Jian
authors.forename: P Q
authors.initials: PQ
authors.lastname: Chen
authors.forename: G Q
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000008:administration & dosage*; D037621:Artemisinins; D002648:Child; D002681:China; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D005334:Fever / Q000469:parasitology; D005500:Follow-Up Studies; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology; D008875:Middle Aged; D012717:Sesquiterpenes / Q000008:administration & dosage*; D013997:Time Factors
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C039060:artenimol