Anti-inflammatory drugs and Alzheimer-type pathology in aging.
Anti-inflammatory drugs have been suggested as a treatment for AD. The authors examined the AD-type pathology in postmortem brain tissue from elderly nondemented individuals who were chronically exposed to anti-inflammatory drugs. The results suggest that 1) these drugs do not affect the formation of either senile plaques or neurofibrillary tangles and 2) nonsteroidal anti-inflammatory drugs may be more effective than steroids in treating AD because of their ability to suppress the microglial activation associated with senile plaques.
Mackenzie
I R
IR
Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, Canada. imackenz@vanhosp.bc.ca
D000368:Aged; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology*; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D007150:Immunohistochemistry
D000893:Anti-Inflammatory Agents