title: [Cellular activity in healthy subjects with cardiovascular integral risk factors].
abstract: The study was made of permeability of erythrocytic membrane (PEM), electrokinetic properties of cellular nucleus (ECN) and phagocytic activity of neutrophils (PAN) in whole blood of 130 healthy subjects with integral risk factors of cardiovascular disease. First-level test immunogram was analysed. Hypercholesterolemia and hyperbetalipidemia were associated with high PAN. Obese patients with cardiovascular hereditary load had elevated PAN and PEM. In smokers PEM was elevated but ECN was subnormal, PAN rose in parallel with number of cigarettes smoked for a day. Combination of the risk factors led to low activity of the nucleus and high PAN. It is concluded that healthy subjects with integral risk factors develop changes in functional cell activity.
authors.forename: B V
authors.initials: BV
authors.lastname: Golovskoĭ
authors.forename: A P
authors.initials: AP
authors.lastname: Shavrin
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D002463:Cell Membrane Permeability; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications; D008055:Lipids / Q000097:blood; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D012016:Reference Values; D012307:Risk Factors
chemical_list: D008055:Lipids