Circadian variation in BDNF mRNA expression in the rat hippocampus.
BDNF mRNA levels in the hippocampus were studied during the circadian cycle by in situ hybridization. These levels display a circadian pattern, which may be due to regulation by corticosterone. This may have consequences for hippocampal functioning at different time points of the circadian cycle.
Schaaf
M J
MJ
Division of Medical Pharmacology, Sylvius Laboratories, Leiden/Amsterdam Center for Drug Research, 2300 RA, Leiden, Netherlands.
Duurland
R
R
de Kloet
E R
ER
Vreugdenhil
E
E
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis / Q000235:genetics*; D002940:Circadian Rhythm / Q000235:genetics*; D003345:Corticosterone / Q000502:physiology; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000378:metabolism*; D017403:In Situ Hybridization; D066298:In Vitro Techniques; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar
D019208:Brain-Derived Neurotrophic Factor; D012333:RNA, Messenger; D003345:Corticosterone