title: Cernuosides A and B, two sucrase inhibitors from Pulsatilla cernua.
abstract: Two oleanane-type oligoglycosides, cernuosides A (1) and B (2), were isolated from the roots of Pulsatilla cernua (Ranunculaceae). Structure elucidation was accomplished by 1D and 2D NMR (DQF-COSY, TOCSY, HMQC, HMBC, and ROESY) methods, FABMS, and hydrolysis. Both compounds showed moderate activity against sucrase.
authors.affiliation: Department of Phytochemistry, China Pharmaceutical University, Nanjing, People's Republic of China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: W
authors.initials: W
authors.lastname: Ye
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.forename: G
authors.initials: G
authors.lastname: Zhu
authors.forename: C T
authors.initials: CT
authors.lastname: Che
authors.forename: S
authors.initials: S
authors.lastname: Zhao
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002681:China; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006868:Hydrolysis; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013393:Sucrase / Q000037:antagonists & inhibitors*
chemical_list: D004791:Enzyme Inhibitors; D006027:Glycosides; C406770:cernuoside A; C406771:cernuoside B; D009828:Oleanolic Acid; D013393:Sucrase