[Relationship between plasma NO and PaO2 of artery blood in the patients with chronic pulmonary heart disease].
The plasma nitric oxide(NO) level in the 28 patients with chronic pulmonary heart disease and health controls were measured. The results showed that NO level in the exacerbating patients and stable patients was significantly lower than that in health controls. The NO level in the patients getting worse was markedly lower than that in the stable patients. The lower the oxygen pressure of the artery blood (PaO2), the lower the NO level. when the patient's situation was improving, the plasma NO level increased with rising PaO2. The plasma NO level in patients was associated with the PaO2. This study suggests that the sustained pulmonary hypertension caused by chronic hypoxia may relate to the reduction of NO synthesis and release, and that NO may play an important role in the pathogenesis in chronic pulmonary heart disease.
Zhou
R
R
Department of Internal Medicine, Second Affililated Hospital, Hunan Meddical University, Changsha.
Li
B
B
Fang
J
J
D000368:Aged; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010100:Oxygen / Q000097:blood*
D009569:Nitric Oxide; D010100:Oxygen