Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats.
The hydro-alcohol extract of the dry leaves of Peumus boldus and boldine, showed abortive and teratogenic action and changes in the blood levels of bilirubin, cholesterol, glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and urea in rats. The long term administration of the extract and boldine did not cause histological modification during a period of 90 days.
Almeida
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Laboratório de Farmacologia do Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife, Pernambuco, CEP 50670-901, Brazil.
Melo
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AM
Xavier
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D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000633:toxicity*; D001060:Aporphines / Q000097:blood / Q000633:toxicity*; D001774:Blood Chemical Analysis; D020964:Embryo Loss / Q000139:chemically induced; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D019770:Lauraceae / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000097:blood / Q000633:toxicity; D018515:Plant Leaves / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013723:Teratogens / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001060:Aporphines; D010936:Plant Extracts; D013723:Teratogens; C011686:boldine