T-cell lymphoproliferative disorder of vitreous associated with mycosis fungoides.
59-year-old man with a history of mycosis fungoides developed loss of visual acuity and visual field in the left eye. Epiretinal lesions were present in the right eye and multifocal choroidal lesions, optic disc edema, and vitritis were present in the left eye. A diagnostic vitrectomy was performed and cytologic examination of the vitreous confirmed the diagnosis of T-cell lymphoproliferative disorder. Systemic and intrathecal chemotherapy resulted in marked improvement in ocular signs and symptoms. At last follow-up, the patient was found to have improved visual acuity in the left eye; however, significant worsening of his systemic condition developed and he died shortly thereafter.
Williams
G C
GC
Department of Ophthalmology, Baylor College of Medicine, USA.
Holz
E
E
Lee
A G
AG
Font
R L
RL
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002830:Choroid Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D005134:Eye Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D019574:Optic Nerve Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology*; D014821:Vitrectomy; D014822:Vitreous Body / Q000187:drug effects / Q000473:pathology*