Gastrointestinal osmoreceptors and renal sodium excretion in humans.
The hypothesis that natriuresis can be induced by stimulation of gastrointestinal osmoreceptors was tested in eight supine subjects on constant sodium intake (150 mmol NaCl/day). A sodium load equivalent to the amount contained in 10% of measured extracellular volume was administered by a nasogastric tube as isotonic or hypertonic saline (850 mM). In additional experiments, salt loading was replaced by oral water loading (3.5% of total body water). Plasma sodium concentration increased after hypertonic saline (+3.1 +/- 0.7 mM), decreased after water loading (-3.8 +/- 0.8 mM), and remained unchanged after isotonic saline. Oncotic pressure decreased by 9.4 +/- 1.2, 3.7 +/- 1.2, and 10.7 +/- 1.3%, respectively. Isotonic saline induced an increase in renal sodium excretion (104 +/- 15 to 406 +/- 39 micromol/min) that was larger than seen with hypertonic saline (85 +/- 15 to 325 +/- 39 micromol/min) and water loading (88 +/- 11 to 304 +/- 28 micromol/min). Plasma ANG II decreased to 22 +/- 6, 35 +/- 6, and 47 +/- 5% of baseline after isotonic saline, hypertonic saline, and water loading, respectively. Plasma atrial natriuretic peptide (ANP) concentrations and urinary excretion rates of endothelin-1 were unchanged. In conclusion, stimulation of osmoreceptors by intragastric infusion of hypertonic saline is not an important natriuretic stimulus in sodium-replete subjects. The natriuresis after intragastric salt loading was independent of ANP but can be explained by inhibition of the renin-angiotensin system.
Andersen
L J
LJ
Department of Medical Physiology, Panum Institute, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Jensen
T U
TU
Bestle
M H
MH
Bie
P
P
D000328:Adult; D000804:Angiotensin II / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D004068:Digestive System Physiological Phenomena; D004326:Drinking / Q000502:physiology; D019332:Endothelin-1 / Q000652:urine; D006801:Humans; D007441:Intubation, Gastrointestinal; D007552:Isotonic Solutions / Q000008:administration & dosage / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism*; D008297:Male; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage / Q000494:pharmacology; D012964:Sodium / Q000652:urine*; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000502:physiology*
D019332:Endothelin-1; D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D012965:Sodium Chloride; D009320:Atrial Natriuretic Factor; D012964:Sodium