title: Synthesis and anticonvulsant activity of some (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones.
abstract: Fifteen new (2/4-substituted)benzaldehyde (2-oxobenzothiazolin-3-yl)acetohydrazones were synthesized and their structures were elucidated by NMR and elemental analysis. Their anticonvulsant activity was tested by a pentylenetetrazole induced seizure test. Compounds 4e and 4h were found to be the most promising among the others.
authors.affiliation: Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Cakir
authors.forename: E
authors.initials: E
authors.lastname: Yildirim
authors.forename: T
authors.initials: T
authors.lastname: Ercanli
authors.forename: K
authors.initials: K
authors.lastname: Erol
authors.forename: M F
authors.initials: MF
authors.lastname: Sahin
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D001547:Benzaldehydes; D013844:Thiazoles