[L-arginine and nitric oxide have effects on glomerulus hyperperfusion of early diabetic rats].
We used streptozotocin (STZ) to induce the animal model of diabetes mellitus in rats. On the 7th and 14th days of induction, kidney disorder, the levels of NO3- in plasma and tissue homogenate in different periods were observed. The NO3- levels in relation to the application of L-arginine (L-Arg) were also noted. The results showed that the kidney weight/body weight ratio significantly increased in different periods (P < 0.05). On the 7th day profuse proteinuria appeared and it markedly increased on the 14th day: creatinine clearance rate (Ccr) significantly raised, too (P < 0.005). The NO3- levels in plasma and tissue homogenate were getting higher with time. The level of NO3- significantly increased after L-Arg was perfused. It indicated that kidney disorder was present at the early stage of diabetes, and the raised Ccr indirectly indicated the increase of glomerular filtration rate. These suggest that NO3- and L-Arg may be important mediums which have effects of hyperfiltration and hyperperfusion of glomerulus.
Huang
S
S
Department of Kidney, First Affiliated Hospital, Chengdu.
Fu
P
P
Li
X
X
Zhang
X
X
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000473:pathology; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D009569:Nitric Oxide; D001120:Arginine