[Study of superinfection of HBV and HCV].
OBJECTIVE
To understand the situation in hepatitis B patients coinciding with HCV and to explore its influence on HCV on the replication of HBV.


METHODS
Using ELISA, 712 hepatitis B patients were tested for serum anti-HCV and markers of HBV.


RESULTS
Of the 712 patients, anti-HCV positive rate was 14.47% with the highest 48.98% in patients with severe hepatitis and the lowest 3.25% in patients with acute hepatitis. Markedly different anti-HCV positive rates (P < 0.001) in patients of different clinical stages were discovered. The more severe the case with longer the course, the higher the anti-HCV positive rates. In patients with superinfection of HBV and HCV, serum HBsAg, HBeAg and anti-HBcIgM positive rates were lower than those in patients with hepatitis B (P < 0.001, P < 0.001 and P < 0.05) but the anti-HBe positive rates were higher. All the differences showed an obvious statistical significance.


CONCLUSIONS
Hepatitis B coinciding with HCV infection is responsible for the deterioration of the disease and towards its formation of its chronic phase as well as for the inhibition of HBV replication.
Chen
X
X
Taishan Medical College, Shandong Province.
Xuan
M
M
Wu
D
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000254:growth & development; D006526:Hepatitis C / Q000453:epidemiology*; D018937:Hepatitis C Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015163:Superinfection; D014779:Virus Replication
D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D018937:Hepatitis C Antibodies