Use of CpG DNA for enhancing specific immune responses.
CpG ODN, owing to its wide range of immunostimulatory effects has been found to be a potent Th1-type adjuvant that is effective with virtually any type of antigen, although responses are less impressive with PS than protein antigens. The use of CpG ODN as an adjuvant may allow the development of vaccines against a wider range of diseases, which could include therapeutic vaccines for chronic infections or cancer, effective pediatric vaccines for newborns, and easily delivered mucosal vaccines.
Davis
H L
HL
Loeb Health Research Institute, Ottawa, ON, Canada. hdavis@LRI.ca
D000818:Animals; D000941:Antigens / Q000276:immunology; D018899:CpG Islands / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans; D019444:Vaccines, DNA / Q000276:immunology*
D000941:Antigens; D019444:Vaccines, DNA; D004247:DNA