title: Serum tumor marker CA 125 is an early and sensitive indicator of veno-occlusive disease in children undergoing bone marrow transplantation.
abstract: Veno-occlusive disease (VOD) is a potentially lethal complication of patients undergoing bone marrow transplantation (BMT). The diagnosis of VOD is currently based on clinical signs and unspecific laboratory findings. CA 125 is an oncofetal antigen used as a tumor marker in various malignancies, especially in those originating from the female reproductive tract or gastrointestinal organs, whereas serum CA 125 levels are not increased in hematological malignancies. Several pathophysiological alterations occurring in VOD may lead to elevations in serum CA 125 levels. Therefore, we explored the behavior of this marker as a diagnostic tool in VOD. Twenty-nine pediatric transplant patients were studied. Eight patients (28%) developed clinical VOD, and a significant increase in serum CA 125 was noted in all of them. During the 7 days preceding the diagnosis of VOD, an increase of at least 57% in serum CA 125 from the pre-BMT value was observed in 6 (86%) of 7 of the evaluable patients with VOD. In contrast, a similar increase was noted in only 6 of the 21 non-VOD patients during the post-BMT period of 30 days. Accordingly, the sensitivity and specificity of serum CA 125 for predicting or detecting VOD were 86% and 71%, respectively. The serum levels of CA 125 were not affected by the presence of Graft-versus-Host Disease (GvHD) or a septic infection. In conclusion, serum CA 125 is of value as an early marker of VOD in children undergoing BMT.
authors.affiliation: Children's Hospital, University of Helsinki, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Petäjä
authors.forename: S
authors.initials: S
authors.lastname: Pitkänen
authors.forename: K
authors.initials: K
authors.lastname: Vettenranta
authors.forename: A
authors.initials: A
authors.lastname: Fasth
authors.forename: M
authors.initials: M
authors.lastname: Heikinheimo
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation; D018394:CA-125 Antigen / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D010022:Osteopetrosis / Q000175:diagnosis; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000175:diagnosis; D016511:Severe Combined Immunodeficiency / Q000175:diagnosis; D014652:Vascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology
chemical_list: D015415:Biomarkers; D018394:CA-125 Antigen