title: Auditory evoked potentials in the assessment of central nervous system effects of antimigraine drugs.
abstract: Because the "intensity dependence" of cortical auditory evoked potentials (IDAP) is under serotonergic control, it can be used to assess central antimigraine effects of 5HT1B/1D agonists. We measured IDAP before and 2 h after naratriptan (5 mg, n = 19) and zolmitriptan (5 mg, n = 19) in healthy volunteers. IDAP was expressed as the amplitude-stimulus intensity function ("ASF slope"). Naratriptan tended to increase ASF slope (mean difference 0.23 +/- 0.62 microV/10 dB, p = 0.06) while zolmitriptan (0.08 +/- 0.95 microV/10 dB, p = 0.35) did not. We assessed the suitability of IDAP for measuring central antimigraine drug effects using repeatability data (see companion paper). We calculated the trade-off between the size of the expected drug effects (ASF slope difference) and the necessary sample size. Because of poor repeatability 36 to 80 subjects are required to detect ASF slope changes in the 0.25-0.5 microV/10 dB range. These data can be used to design trials using IDAP.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, The Netherlands.
authors.forename: K I
authors.initials: KI
authors.lastname: Roon
authors.forename: P S
authors.initials: PS
authors.lastname: Sándor
authors.forename: G G
authors.initials: GG
authors.lastname: Schoonman
authors.forename: F P
authors.initials: FP
authors.lastname: Lamers
authors.forename: J
authors.initials: J
authors.lastname: Schoenen
authors.forename: M D
authors.initials: MD
authors.lastname: Ferrari
authors.forename: J G
authors.initials: JG
authors.lastname: van Dijk
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D010880:Piperidines / Q000494:pharmacology*; D015203:Reproducibility of Results; D018401:Sample Size; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014363:Tryptamines
chemical_list: D007211:Indoles; D010080:Oxazoles; D023303:Oxazolidinones; D010880:Piperidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C089750:zolmitriptan; C106783:naratriptan