Is factor V Leiden a risk factor for fetal loss?
A successful pregnancy is dependent on the development of adequate placental circulation. The abnormalities of placental vasculature may result in a number of gestational pathologies, including fetal loss. The aim of our study was to determine whether women with f V Leiden are at an increased risk of pregnancy loss. For this purpose we assessed three groups of women. In a prospective group we examined 30 females with spontaneous abortions for f V Leiden. In a retrospective group we assessed the frequency of abortions in 80 women (172 pregnancies) with f V Leiden (72 heterozygous, 8 homozygous) from 57 unrelated families. In a control group we evaluated the frequency of abortions in 45 women without f V Leiden. Factor V Leiden was found in 3% of women in the 1st group. Fetal loss occurred in 10% of women in the 2nd group and in 9% in the 3rd group. Factor V Leiden was not found to be a risk factor for fetal loss in our study group.
Dulícek
P
P
Department of Clinical Haematology, University Teaching Hospital, Hradec Králové. dulicek@fnhk.cz
Chrobák
L
L
Kalousek
I
I
Pesavová
L
L
Pecka
M
M
Stránský
P
P
D000022:Abortion, Spontaneous / Q000209:etiology / Q000235:genetics*; D020016:Activated Protein C Resistance / Q000235:genetics; D000328:Adult; D005165:Factor V / Q000032:analysis* / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors
C095381:factor V Leiden; D005165:Factor V