title: Eukaryotic DNA polymerases, a growing family.
abstract: In eukaryotic cells, DNA polymerases are required to maintain the integrity of the genome during processes, such as DNA replication, various DNA repair events, translesion DNA synthesis, DNA recombination, and also in regulatory events, such as cell cycle control and DNA damage checkpoint function. In the last two years, the number of known DNA polymerases has increased to at least nine (called alpha, beta, gamma, delta, epsilon, zeta, eta, t and iota), and yeast Saccharomyces cerevisiae contains REV1 deoxycytidyl transferase.
authors.affiliation: Institute of Veterinary Biochemistry, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. hubscher@vetbio.unizh.ch
authors.forename: U
authors.initials: U
authors.lastname: Hübscher
authors.forename: H P
authors.initials: HP
authors.lastname: Nasheuer
authors.forename: J E
authors.initials: JE
authors.lastname: Syväoja
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004258:DNA Polymerase III / Q000378:metabolism; D019951:DNA Polymerase beta / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000201:enzymology*; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D009713:Nucleotidyltransferases; D029701:Saccharomyces cerevisiae Proteins; D000094769:DNA Polymerase iota; D000097462:DNA Polymerase theta; D000099270:Y-Family DNA Polymerases
chemical_list: D004247:DNA; D004258:DNA Polymerase III; D019951:DNA Polymerase beta; D004259:DNA-Directed DNA Polymerase; D005656:Fungal Proteins; D009713:Nucleotidyltransferases; D029701:Saccharomyces cerevisiae Proteins; D000094769:DNA Polymerase iota; D000097462:DNA Polymerase theta; C100951:REV1 protein, S cerevisiae; D000099270:Y-Family DNA Polymerases; C112338:Rad30 protein; C000722070:POLI protein, human