[Clinical study of fructose 1,6-diphosphate on myocardial ischemia/reperfusion injuries].
Twenty ventricular septal defect patients who underwent cardiopulmonary bypass (CPB) were divided into 1,6-diphosphate group and controlled group (10 cases each). Blood samples were taken at pre- and post-cardiopulmonary bypass 30 min, 6 h, and 24 h to determine lactate dehydrogenase enzyme(LDH), creatine kinase enzyme(CK) and its isoenzyme(CK-MB) levels. We found that 1,6-diphosphate decreased the increasing levels of LDH, CK, and CK-MB after cardiopulmonary bypass. It is suggested that 1,6-diphosphate may attenuate myocardial ischemia/reperfusion injuries during cardiopulmonary bypass.
Liu
J
J
Department of Anesthesiology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Li
L
L
Wang
Y
Y
Chang
Y
Y
D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D003402:Creatine Kinase / Q000097:blood; D005635:Fructosediphosphates / Q000008:administration & dosage*; D006345:Heart Septal Defects, Ventricular / Q000201:enzymology / Q000601:surgery*; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*
D002314:Cardioplegic Solutions; D002317:Cardiovascular Agents; D005635:Fructosediphosphates; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; C029063:fructose-1,6-diphosphate