title: Body surface mapping of retrograde P waves in the intact dog by simulation of accessory pathway re-entry.
abstract: OBJECTIVE
  To investigate a noninvasive technique to localize the atrial insertion site of concealed accessory pathways based on the analysis of body surface potential maps (BSPMs) of retrograde P waves in dogs with simulated retrograde pathways.
  
  
  METHODS
  Orthodromic tachycardias were simulated by atrial stimulations at eight different sites around the atrioventricular ring with long (250 ms and 300 ms) and short (100 ms and 130 ms) coupling times in 14 anesthetized dogs to have P waves well separated from the T wave or occurring during the T wave, respectively. The distance between pacing sites was 15 to 40 mm in group 1 (eight dogs) and 2 mm (in the right atrial free wall region) in group 2 (six dogs). Beats were signal-averaged during 30 s and BSPMs were constructed from 63 unipolar leads.
  
  
  RESULTS
  The P wave BSPM pattern for any specific stimulation site was stable and reproducible (correlation coefficient greater than 0.98), and similar in different dogs at long coupling interval stimulations. The thoracic distribution of negative potentials and position of the potential minimum clearly identified the stimulation site when long coupling time stimulations were used. The spatial resolution of the technique as determined by comparison of correlation coefficients in group 2 was 6 mm (P<0.05). When short coupling time stimulations were used (fast tachycardia simulation), the T wave masked the P wave potential distribution in four of eight dogs, but the retrograde P wave map could still be accurately extracted by subtracting a straight line joining the onset and offset of the P wave in 24 of 28 (86%) of the tachycardia simulation sites in these four dogs.
  
  
  CONCLUSIONS
  The BSPM patterns of simulated retrograde P waves are specifically related to the site of atrial stimulation. Although the T wave altered these BSPM patterns, a subtraction technique recovered the pattern of the retrograde P wave in 93% of all simulated orthodromic tachycardias. The spatial resolution of the retrograde P wave BSPM method was 6 mm.
authors.affiliation: Hôpital du Sacré-C ur, Montréal, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Pintér
authors.forename: F
authors.initials: F
authors.lastname: Molin
authors.forename: P
authors.initials: P
authors.lastname: Savard
authors.forename: G
authors.initials: G
authors.lastname: Tremblay
authors.forename: G
authors.initials: G
authors.lastname: Sierra
authors.forename: R
authors.initials: R
authors.lastname: Nadeau
mesh_terms: D000818:Animals; D018780:Body Surface Potential Mapping; D002304:Cardiac Pacing, Artificial; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008297:Male; D012815:Signal Processing, Computer-Assisted; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000175:diagnosis / Q000503:physiopathology*; D014927:Wolff-Parkinson-White Syndrome / Q000175:diagnosis / Q000503:physiopathology