[An experimental study on promoting reconstruction of microcirculation of the ischemic skin flap with basic fibroblast growth factor].
OBJECTIVE
This study was to determine whether the basic fibroblast growth factor (bFGF) could promote reconstruction of microcirculation in the ischemic portion of a random skin flap.


METHODS
Five methods were used in the experiment: measurement of the survival area of the skin flap; light and electron microscopic studies; immunohistochemical observation of the endothelial cell and microvessel image analysis technology (IAT).


RESULTS
The survival area and microvessels in the skin flap were significantly increased in the treated group. The results indicate that bFGF can stimulate the proliferation and differentiation of endothelial cells in vivo and promote the microcirculation of the ischemic flap.


CONCLUSIONS
bFGF could promote reconstruction of microcirculation of the ischemic skin flap.
Guo
C
C
Clinical College of Chongqing Medical University.
Zhang
Y
Y
Zhang
D
D
D000818:Animals; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006085:Graft Survival / Q000187:drug effects; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps
D016222:Fibroblast Growth Factor 2