[Relationship of C-erbB-2 oncogene overexpression to estrogen progesterone receptors in brease cancer and its prognostic significance].
In order to understand the relationship of C-erbB-2 oncogene overexpression to ER and PR in breast cancer and its prognostic significance, we examined overexpression of C-erbB-2 oncogene in 106 breast carcinomas by using immunohistochemical techniques (LSAB). The results showed that the positive rate of C-erbB-2 overexpression was 63.21% (67/106). The overexpression of C-erbB-2 oncogene related negatively with survival. 81.63% of the cases with overexpression of C-erbB-2 oncogene survived < or = 5 years and 34.29% survived > 10 years. There were significant associations of C-erbB-2 overexpression with advance clinical stage, high histological grade, and positive axillary node status in breast cancers. Negative relationship between hormone receptors and C-erbB-2 oncogene. All of these findings suggested that overexpression of C-erbB-2 oncogene might be an important prognostic factor and the detection of C-erbB-2 oncogene might be arranged as a regular pathological examination in the cases of breast cancer.
Yang
J
J
Department of General Surgery, First Affiliated Hospital, Chengdu.
Xing
T
T
Yao
X
X
Hu
R
R
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D018734:Genes, erbB-2; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone