title: Chronic cardiac denervation affects the speed of coronary vascular regulation.
abstract: OBJECTIVE
  We tested the hypothesis that the rate of adaptation of coronary metabolic vasodilatation and autoregulation is modulated by the cardiac nerves.
  
  
  METHODS
  Anaesthetised dogs (seven innervated (control) and seven with denervated hearts) were subjected to controlled pressure perfusion of the left main coronary artery. Heart rate was controlled by pacing.
  
  
  RESULTS
  The steady state autoregulation curves and metabolic regulation curves were similar in the two groups. A sudden increase or decrease in heart rate was associated with a faster response (22% shorter half-times) in the innervated than the denervated dogs (P < 0.001). A sudden increase or decrease in coronary arterial perfusion pressure was associated with a slower response (24% longer half-times) in the innervated than the denervated hearts (P < 0.005).
  
  
  CONCLUSIONS
  We conclude that the speed of response to metabolic and perfusion pressure changes is partly mediated by cardio-cardiac reflexes. Reflex coronary vasodilatation appears to reinforce the metabolic vasodilatation of a heart rate increase and oppose the vasoconstriction in response to increased perfusion pressure.
authors.affiliation: Department of Medical Physics, Academic Medical Centre, University of Amsterdam, The Netherlands. I.Vergroesen@amc.uva.nl
authors.forename: I
authors.initials: I
authors.lastname: Vergroesen
authors.forename: D
authors.initials: D
authors.lastname: Merkus
authors.forename: J W
authors.initials: JW
authors.lastname: van Teeffelen
authors.forename: J
authors.initials: J
authors.lastname: Dankelman
authors.forename: J A
authors.initials: JA
authors.lastname: Spaan
authors.forename: H B
authors.initials: HB
authors.lastname: van Wezel
authors.forename: M I
authors.initials: MI
authors.lastname: Noble
authors.forename: A J
authors.initials: AJ
authors.lastname: Drake-Holland
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D002304:Cardiac Pacing, Artificial; D003326:Coronary Circulation; D003714:Denervation; D004285:Dogs; D005260:Female; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D006706:Homeostasis; D008297:Male; D010101:Oxygen Consumption; D012018:Reflex; D013997:Time Factors; D014666:Vasomotor System