title: [Expression of protein p53 in superficial transitional carcinoma of the bladder with differing course].
abstract: OBJECTIVE
  To determine the prognostic value of p53 protein expression in relation to progression of superficial bladder cancer.
  
  
  METHODS
  A retrospective study was conducted in which p53 protein was determined in TUR fragments of 18 patients with superficial transitional cell carcinoma of the bladder with no evidence of tumor progression in the last 6 years and in 13 patients with superficial tumors that had become invasive. DO-7 monoclonal antibody was utilized (+if stained nuclei were more than 25%).
  
  
  RESULTS
  Expression of p53 protein was found in 9 patients (50%) with bladder tumors that had not progressed and in 6 patients (46.1%) with bladder tumors that had become invasive (p = 0.83).
  
  
  CONCLUSIONS
  Determination of p53 protein was not related with cancer progression in this series.
authors.affiliation: Servicio de Urología y Anatomía Patológica, Hospital Son Dureta, Palma de Mallorca, España.
authors.forename: M
authors.initials: M
authors.lastname: Rebassa Llull
authors.forename: C
authors.initials: C
authors.lastname: Gutiérrez Sanz-Gadea
authors.forename: D
authors.initials: D
authors.lastname: Muñoz Vélez
authors.forename: M
authors.initials: M
authors.lastname: Esteva Bauzá
authors.forename: C
authors.initials: C
authors.lastname: Gómez Bellvert
authors.forename: A
authors.initials: A
authors.lastname: Mus Malleu
authors.forename: V
authors.initials: V
authors.lastname: Riera Marí
authors.forename: F
authors.initials: F
authors.lastname: Hidalgo Pardo
authors.forename: I
authors.initials: I
authors.lastname: Torrens Darder
authors.forename: M
authors.initials: M
authors.lastname: Ozonas Moragues
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*; D001749:Urinary Bladder Neoplasms / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53