Nonsteroidal anti-inflammatory drug use in dentistry: gastrointestinal implications.
Pain management long has been an important consideration in dental care. Nonopioid analgesics such as aspirin, acetaminophen, and many of the nonsteroidal anti-inflammatory drugs (NSAIDs) generally provide predictable outcomes for control of dental pain because of their analgesic and anti-inflammatory properties. The anti-inflammatory action of NSAIDs also is being investigated in treatment of periodontal disease when used as an adjunct to non-surgical management. Since NSAID use by dental patients is high, gastrointestinal complications may arise, affecting long-term use of these agents. Systemic considerations of NSAID use are reviewed, as are complications frequently resulting in ulceration of the gastric mucosa.
Nguyen
A M
AM
Baylor College of Medicine, Houston, TX, USA.
Graham
D Y
DY
Gage
T
T
Griffiths
G R
GR
D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000188:drug therapy / Q000201:enzymology; D010518:Periodontitis / Q000188:drug therapy*; D014098:Toothache / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D016861:Cyclooxygenase Inhibitors; D016595:Misoprostol; D009853:Omeprazole