[Application and analysis of biochemical indices for the evaluation of antisilicosis treatment. Study on anti-silicosis therapy and its evaluation research group].
The levels of serum Ceruloplasmin (Cp), Superoxide dismutase (SOD) and IgG of 296 silicosis patients treated by tetrandrine, polyvinylpridine-N-Oxide, hydroxypiperaquinoline phosphate and aluminium citrate were measured. Sera were collected before and after the 1st, 3rd and 6th therapy courses. 144 Silicosis patients without treatment were observed as controls. The levels of these three indices decreased by the end of treatment. The levels of SOD were fluctuated, which were increased after the 3rd course, but decreased after the 1st and 6th courses. The decrease of Cp, SOD and IgG consisted with the clinical effectiveness of the treatment, indicating that Cp, SOD and IgG were appropriate biochemical indicators for the evaluation of antisilicosis drugs. The quality control and the statistics standardization for data analysis are important.
Liu
B
B
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing, China.
Qin
X
X
D000470:Alkaloids / Q000627:therapeutic use*; D044182:Benzylisoquinolines; D002570:Ceruloplasmin / Q000378:metabolism; D004359:Drug Therapy, Combination; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D011144:Polyvinylpyridine N-Oxide / Q000627:therapeutic use*; D012829:Silicosis / Q000097:blood / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood*
D000470:Alkaloids; D044182:Benzylisoquinolines; D007074:Immunoglobulin G; C009438:tetrandrine; D011144:Polyvinylpyridine N-Oxide; D013482:Superoxide Dismutase; D002570:Ceruloplasmin