[A case with HTLV-I associated myelopathy (HAM) accompanied by primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH)].
We reported a 60-year-old female patient with HTLV-I associated myelopathy (HAM) accompanied by primary biliary cirrhosis (PBC) and autoimmune hepatitis (AIH). The diagnosis of PBC and AIH was confirmed by liver biopsy. HAM is considered to be mediated by cellular immune mechanisms, while humoral immune mechanisms may play a predominant role in the development of PBC and AIH. Flowcytometric analysis of lymphocyte subset of peripheral blood was within normal limits. We then collected CD4 positive cells from the patient. These cells expressed T helper 2 (Th 2) cytokine mRNA such as IL-4 and IL-10, but did not express Th 1 cytokines, indicating the predominance of Th 2 in this patient. This case suggested the possibility that disease associated Th 2 might develop in the course of Th1-mediated disease like HAM.
Nagami
S
S
Department of Neurology Kisiwada City Hospital.
Konisi
T
T
Kataoka
H
H
Kikui
S
S
Takayanagi
T
T
Suzumura
A
A
D005260:Female; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D008105:Liver Cirrhosis, Biliary / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000150:complications / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D016753:Interleukin-10; D015847:Interleukin-4