title: Inflammation after sclerocorneal versus clear corneal tunnel phacoemulsification.
abstract: OBJECTIVE
  To compare the postoperative inflammation after phacoemulsification followed by intraocular lens (IOL) implantation by means of sclerocorneal versus clear corneal tunnel incision.
  
  
  METHODS
  Randomized controlled clinical trial.
  
  
  METHODS
  One hundred eyes of 100 patients were examined at a German University eye hospital.
  
  
  METHODS
  One hundred eyes with cataract necessitating phacoemulsification with posterior chamber IOL implantation were randomly assigned to receive a temporal sclerocorneal or clear corneal tunnel incision by a single surgeon.
  
  
  METHODS
  Preoperative and postoperative inflammation was evaluated by measurement of flare using laser flare photometry. Statistical inference was mainly based on nonparametric group comparisons by use of two sample Wilcoxon tests.
  
  
  RESULTS
  Mean anterior chamber flare in the group with sclerocorneal tunnel increased from 7.5 photon counts/ms preoperatively to 19.6 at 6 hours postoperatively and decreased to 11.1 (day 1), 11.7 (day 2), 11.6 (day 3), and 9.2 (5 months) during the postoperative course. The mean flare in the clear corneal tunnel incision group increased from 7.7 preoperatively to 12.9 at 6 hours postoperatively and then decreased to 9.2 (day 1), 9.8 (day 2), 9.1 (day 3), and 9.2 (5 months). Individual postoperative flare changes were significantly lower in the clear corneal tunnel group at the day of surgery (P<0.0001), as well as at day 1 (P = 0.0011), day 2 (P = 0.0079), and day 3 (P = 0.0020). After 5 months, no statistically significant difference was found.
  
  
  CONCLUSIONS
  After phacoemulsification and foldable IOL implantation, postoperative alteration in the blood-aqueous barrier was statistically significantly lower with the clear corneal tunnel incision group compared with the sclerocorneal incision group, in the first 3 days postoperatively.
authors.affiliation: Department of Ophthalmology, Johannes Gutenberg-University, Mainz, Germany.
authors.forename: H B
authors.initials: HB
authors.lastname: Dick
authors.forename: O
authors.initials: O
authors.lastname: Schwenn
authors.forename: F
authors.initials: F
authors.lastname: Krummenauer
authors.forename: R
authors.initials: R
authors.lastname: Krist
authors.forename: N
authors.initials: N
authors.lastname: Pfeiffer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000473:pathology*; D018916:Blood-Aqueous Barrier; D003315:Cornea / Q000601:surgery*; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies; D012029:Refraction, Ocular; D012590:Sclera / Q000601:surgery*; D014606:Uveitis, Anterior / Q000209:etiology* / Q000473:pathology; D014792:Visual Acuity