title: Enzyme evolution. Design by necessity.
authors.forename: G A
authors.initials: GA
authors.lastname: Petsko
mesh_terms: D019747:Aldose-Ketose Isomerases / Q000737:chemistry / Q000235:genetics; D019020:Directed Molecular Evolution; D007209:Indole-3-Glycerol-Phosphate Synthase / Q000737:chemistry / Q000235:genetics; D016296:Mutagenesis; D017510:Protein Folding; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; D007209:Indole-3-Glycerol-Phosphate Synthase; D019747:Aldose-Ketose Isomerases; C029865:phosphoribosylanthranilate isomerase