title: Metaplastic carcinoma of the breast arising within complex sclerosing lesion: a report of five cases.
abstract: OBJECTIVE
  This study presents a series of five cases in which metaplastic carcinoma, predominantly low-grade adenosquamous carcinoma, of the breast is seen arising within a background of a complex sclerosing lesion. This association has been recognized previously but has not been documented in detail. This study describes the characteristics of the components present in each case and discusses the existing literature. This observation adds further evidence to support an association between some types of invasive breast carcinoma and sclerosing lesions of the breast.
  
  
  RESULTS
  Four of these cases were received as referral cases for opinion. The fifth was received as part of the routine surgical workload within our own institution. Two patients presented following mammographic screening and three symptomatically; their mean age was 62 years (range 49-68). The mean lesion size was 16 mm (range 7-24). All five lesions showed features of a complex sclerosing lesion/radial scar in the form of central sclerosis with elastosis and radiating benign entrapped tubules. One had associated benign papillary structures and two had focal benign squamous metaplasia. Four cases showed coexisting but distinct areas of low-grade adenosquamous carcinoma with glandular and squamous epithelial differentiation in a spindle cell background. One case had associated undifferentiated spindle cell carcinoma. Detailed immunophenotypic characteristics of two cases are presented.
  
  
  CONCLUSIONS
  This series illustrates a postulated but previously unconfirmed association between an unusual form of metaplastic breast carcinoma (adenosquamous carcinoma) and complex sclerosing lesions. The mechanisms of induction of breast carcinoma are poorly understood but these observations further emphasize the potential for sclerosing lesion of the breast to be associated with, and possibly give rise to, invasive carcinoma of different types. The precise nature of the interaction between the pathological processes remains unclear.
authors.affiliation: Department of Histopathology, Nottingham City Hospital, Nottingham, UK.
authors.forename: H
authors.initials: H
authors.lastname: Denley
authors.forename: S E
authors.initials: SE
authors.lastname: Pinder
authors.forename: P H
authors.initials: PH
authors.lastname: Tan
authors.forename: C S
authors.initials: CS
authors.lastname: Sim
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: T
authors.initials: T
authors.lastname: Barker
authors.forename: J
authors.initials: J
authors.lastname: Gearty
authors.forename: C W
authors.initials: CW
authors.lastname: Elston
authors.forename: I O
authors.initials: IO
authors.lastname: Ellis
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000209:etiology / Q000473:pathology*; D018196:Carcinoma, Adenosquamous / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012598:Sclerosis