title: Hypolipemia associated with the wasting condition of rabbits infected with Strongyloides papillosus.
abstract: Rabbits develop a wasting condition in the intestinal stage of Strongyloides papillosus infection. Serum inflammatory cytokine and lipid profiles were investigated in five rabbits infected with S. papillosus and five uninfected pair-fed controls to ascertain whether the disease is inflammatory cytokine-mediated cachexia. Tumor necrosis factor alpha (TNF alpha) was detected in one infected animal at Day 7 after infection. Interleukin (IL)-1 was detected in three infected, and one control, animals at Day 28. IL-6 remained unchanged in both the groups. Infected animals developed hypolipemia, including hypotriglyceridemia in the intestinal stage of infection. Control animals lost body weight in the same manner as the infected animals, but had elevated cholesterols and phospholipids with normal triglyceride concentrations. The results suggested that the wasting condition has no association with cachexia induced by TNF alpha. IL-1 or IL-6, and that hepatic function for lipid synthesis is affected during the intestinal stage of S. papillosus infection.
authors.affiliation: National Institute of Animal Health, Shichinohe, Aomori, Japan. yoshion@niah.affrc.go.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Motokawa
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006400:Hematocrit / Q000662:veterinary; D007009:Hypolipoproteinemias / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007559:Ivermectin / Q000627:therapeutic use; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D010743:Phospholipids / Q000097:blood; D011817:Rabbits / Q000469:parasitology*; D013321:Strongyloides / Q000472:pathogenicity*; D013322:Strongyloidiasis / Q000097:blood / Q000150:complications / Q000662:veterinary*; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D019282:Wasting Syndrome / Q000097:blood / Q000209:etiology / Q000662:veterinary*; D015431:Weight Loss
chemical_list: D000871:Anthelmintics; D005230:Fatty Acids, Nonesterified; D007375:Interleukin-1; D015850:Interleukin-6; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010743:Phospholipids; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D007559:Ivermectin; D002784:Cholesterol