[The relationship between the pathological classifications and molecular genetics of hydatidiform moles].
OBJECTIVE
To study the relationship between the pathological classification and molecular genetics of hydatidiform mole.


METHODS
32 cases of hydatidiform mole were analyzed by DNA restriction fragment length polymorphism (RFLP, hybridized with the probe 33.15).


RESULTS
DNA from only paternal origin was found in 21, and from both parents in 11. In the formeron the basis of pathological characteristics, the complete hydatidiform mole (CHM) and the partial hydatidiform mole (PHM) were 16 (76%, 16/21) and 5 (24%, 5/21) respectively, and in the later CHM and PHM were 5 (45%, 5/11) and 6 (55%, 6/11), respectively.


CONCLUSIONS
There is not much correlation between pathological classification and molecular genetics of hydatidiform mole.
Zhang
X
X
Third Hospital, Beijing Medical University.
Zhang
L
L
Zhou
X
X
D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000145:classification / Q000235:genetics* / Q000473:pathology; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology