Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans.
1. States of peripheral autonomic arousal accompany emotional behaviour, physical exercise and cognitive effort, and their central representation may influence decision making and the regulation of social and emotional behaviours. However, the cerebral functional neuroanatomy representing and mediating peripheral autonomic responses in humans is poorly understood. 2. Six healthy volunteer subjects underwent H215O positron emission tomography (PET) scanning while performing isometric exercise and mental arithmetic stressor tasks, and during corresponding control tasks. Mean arterial blood pressure (MAP) and heart rate (HR) were monitored during scanning. 3. Data were analysed using statistical parametric mapping (SPM99). Conjunction analyses were used to determine significant changes in regional cerebral blood flow (rCBF) during states of cardiovascular arousal common to both exercise and mental stressor tasks. 4. Exercise and mental stressor tasks, relative to their control tasks, were associated with significantly (P < 0.001) increased MAP and HR. Significant common activations (increased rCBF) were observed in cerebellar vermis, brainstem and right anterior cingulate. In both exercise and mental stress tasks, increased rCBF in cerebellar vermis, right anterior cingulate and right insula covaried with MAP; rCBF in pons, cerebellum and right insula covaried with HR. Cardiovascular arousal in both categorical and covariance analyses was associated with decreased rCBF in prefrontal and medial temporal regions. 5. Neural responses in discrete brain regions accompany peripheral cardiovascular arousal. We provide evidence for the involvement of areas previously implicated in cognitive and emotional behaviours in the representation of peripheral autonomic states, consistent with a functional organization that produces integrated cardiovascular response patterns in the service of volitional and emotional behaviours.
Critchley
H D
HD
Wellcome Department of Cognitive Neurology, Institute of Neurology and Autonomic Unit, National Hospital for Neurology and Neurosurgery, Institute of Neurology, University College London, Queen Square, London, UK. hugo@fil.ion.ucl.ac.uk
Corfield
D R
DR
Chandler
M P
MP
Mathias
C J
CJ
Dolan
R J
RJ
D000328:Adult; D001143:Arousal / Q000502:physiology*; D001341:Autonomic Nervous System / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D002320:Cardiovascular Physiological Phenomena; D002560:Cerebrovascular Circulation / Q000502:physiology; D015444:Exercise; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D013315:Stress, Psychological / Q000523:psychology; D014055:Tomography, Emission-Computed