Does the oxidative/glycolytic ratio determine proliferation or death in immune recognition?
Here we discuss the possibility that the way cells utilize fuel(s) for energy confers the properties that can be recognized by the immune system and, reciprocally, that recognition by the immune system can alter the balance of the cell's energy metabolism. We propose that immune recognition, of somatic cells via MHC can alter the their energy metabolism and induce a metabolic shift. We demonstrate the reciprocal relationship that inducing a shift in metabolism toward glycolysis by supplying glucose and insulin results in the upregulation of immunologically recognizable molecules such as cell surface Fas. Thus, immune recognition can induce metabolic deviation. Metabolic deviation can result in altered immune recognition and ultimately in cell proliferation, cell differentiation, or cell death.
Newell
M K
MK
Department of Medicine, University of Vermont College of Medicine, Burlington 05405, USA. mnewell@mail.uccs.edu
Harper
M E
ME
Fortner
K
K
Desbarats
J
J
Russo
A
A
Huber
S A
SA
D000818:Animals; D017209:Apoptosis; D016923:Cell Death / Q000276:immunology / Q000502:physiology*; D002454:Cell Differentiation; D002455:Cell Division / Q000276:immunology / Q000502:physiology*; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D006801:Humans; D007328:Insulin / Q000502:physiology; D008285:Major Histocompatibility Complex; D008954:Models, Biological; D019014:fas Receptor / Q000502:physiology
D007328:Insulin; D019014:fas Receptor; D005947:Glucose