title: HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma.
abstract: Castleman disease (CD) is a lymphoproliferative disorder of unknown etiology that is associated with the development of secondary tumors, including B-cell lymphoma. Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) sequences have been described in some cases of multicentric Castleman disease (MCD). Using a monoclonal antibody against an HHV-8-latent nuclear antigen, we show that HHV-8 is specifically associated with a variant of MCD in which HHV-8-positive plasmablasts that show lambda light-chain restriction localize in the mantle zone of B-cell follicles and coalesce to form microscopic lymphomas in some cases. Furthermore, we show that the frank plasmablastic lymphoma that develops in patients with this plasmablastic variant of MCD is also positive for HHV-8 and lambda light chain. Plasmablastic lymphoma associated with MCD is a new disease entity associated with HHV-8 infection. (Blood. 2000;95:1406-1412)
authors.affiliation: Departments of Oncology, Molecular Pathology and Histopathology, University College London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Dupin
authors.forename: T L
authors.initials: TL
authors.lastname: Diss
authors.forename: P
authors.initials: P
authors.lastname: Kellam
authors.forename: M
authors.initials: M
authors.lastname: Tulliez
authors.forename: M Q
authors.initials: MQ
authors.lastname: Du
authors.forename: D
authors.initials: D
authors.lastname: Sicard
authors.forename: R A
authors.initials: RA
authors.lastname: Weiss
authors.forename: P G
authors.initials: PG
authors.lastname: Isaacson
authors.forename: C
authors.initials: C
authors.lastname: Boshoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D001706:Biopsy; D005871:Castleman Disease / Q000150:complications / Q000473:pathology / Q000821:virology*; D005260:Female; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications; D006566:Herpesviridae Infections / Q000473:pathology / Q000821:virology*; D019288:Herpesvirus 8, Human; D006801:Humans; D007146:Immunoglobulin lambda-Chains; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008223:Lymphoma / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D013154:Spleen / Q000473:pathology / Q000821:virology; D013160:Splenic Neoplasms / Q000473:pathology / Q000821:virology
chemical_list: D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D007146:Immunoglobulin lambda-Chains; D009687:Nuclear Proteins; C109540:latency-associated nuclear antigen