[Influence of portal triad clamping on the intestine in pigs].
A pig model of liver ischemia and intestinal congestion was made by portal triad clamping (PTC) for 45 minutes to investigate the influence of PTC on intestine. The results were as follows: 1. The level of cathepsin D was increased significantly after PTC as compared with the value before clamping (P < 0.05); 2. The endotoxin and lactic acid were significantly increased after PTC comparing with those of pre-clamping (P < 0.05, P < 0.01) and the control group (P < 0.05, P < 0.01); 3. The intestinal mucosa had a significant damage (P < 0.05) after PTC. The results indicate that PTC can result in intestinal mucosal lesion and enterotoxin absorption. Therefore, the protection of intestinal functions is important in hepatic surgery and preoperative bowel preparation should be done.
Liu
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Lu
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Han
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D000818:Animals; D003250:Constriction; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology*; D007511:Ischemia / Q000473:pathology; D008099:Liver / Q000098:blood supply*; D011169:Portal Vein; D013552:Swine