Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model.
BACKGROUND
The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury.


METHODS
Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with alpha set at P<0.05.


RESULTS
Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P<0.01), indicating preserved renal function in rabbits treated with glycyrrhizin.


CONCLUSIONS
Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model.
Subramanian
S
S
Department of Surgery, David Grant Medical Center, Travis AFB, California 94535, USA.
Bowyer
M W
MW
Egan
J C
JC
Knolmayer
T J
TJ
D000818:Animals; D001806:Blood Urea Nitrogen; D019695:Glycyrrhizic Acid / Q000494:pharmacology*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D011817:Rabbits; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D019087:Selectins / Q000502:physiology*; D013997:Time Factors
D019087:Selectins; D019695:Glycyrrhizic Acid