title: 'Full dose' reirradiation of human cervical spinal cord.
abstract: With the progress of modern multimodality cancer treatment, retreatment of late recurrences or second tumors became more commonly encountered in management of patients with cancer. Spinal cord retreatment with radiation is a common problem in this regard. Because radiation myelopathy may result in functional deficits, many oncologists are concerned about radiation-induced myelopathy when retreating tumors located within or immediately adjacent to the previous radiation portal. The treatment decision is complicated because it requires a pertinent assessment of prognostic factors with and without reirradiation, radiobiologic estimation of recovery of occult spinal cord damage from the previous treatment, as well as interactions because of multimodality treatment. Recent studies regarding reirradiation of spinal cord in animals using limb paralysis as an endpoint have shown substantial and almost complete recovery of spinal cord injury after a sufficient time after the initial radiotherapy. We report a case of "full" dose reirradiation of the entire cervical spinal cord in a patient who has not developed clinically detectable radiation-induced myelopathy on long-term follow-up of 17 years after the first radiotherapy and 5 years after the second radiotherapy.
authors.affiliation: Department of Radiation Oncology, SUNY Health Science Center, Syracuse, New York, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ryu
authors.forename: S
authors.initials: S
authors.lastname: Gorty
authors.forename: A M
authors.initials: AM
authors.lastname: Kazee
authors.forename: J
authors.initials: J
authors.lastname: Bogart
authors.forename: S S
authors.initials: SS
authors.lastname: Hahn
authors.forename: P S
authors.initials: PS
authors.lastname: Dalal
authors.forename: C T
authors.initials: CT
authors.lastname: Chung
authors.forename: R H
authors.initials: RH
authors.lastname: Sagerman
mesh_terms: D000328:Adult; D002574:Cervical Vertebrae; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D013116:Spinal Cord / Q000473:pathology / Q000528:radiation effects*; D013118:Spinal Cord Diseases / Q000175:diagnosis / Q000209:etiology*; D013120:Spinal Cord Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D013997:Time Factors