title: Atypical chronic myeloid leukemia with der(20)t(17;20)(q21;q13).
abstract: We present a case of atypical chronic myeloid leukemia that developed blastic transformation four months after initial presentation, with the blast cells showing multilineage antigen expression. A novel karyotypic abnormality, der(20)t(17;20)(q21;q13), was found in bone marrow cells at diagnosis. The potential role of such an aberration in leukemogenesis is discussed.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital, People's Republic of China.
authors.forename: S K
authors.initials: SK
authors.lastname: Ma
authors.forename: T S
authors.initials: TS
authors.lastname: Wan
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: Y L
authors.initials: YL
authors.lastname: Kwong
authors.forename: L C
authors.initials: LC
authors.lastname: Chan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002869:Chromosome Aberrations; D006801:Humans; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics*; D008297:Male