The adenomatous polyposis coli protein.
Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell. First, APC is a component of the Wnt signalling pathway; second, APC may have a role in cell migration; finally, APC may regulate proliferation and apoptosis.
Näthke
I S
IS
Department of Anatomy and Physiology, University of Dundee, UK. i.s.nathke@dundee.ac.uk
D025601:Adenomatous Polyposis Coli Protein; D002468:Cell Physiological Phenomena; D015179:Colorectal Neoplasms / Q000503:physiopathology; D003598:Cytoskeletal Proteins / Q000502:physiology*; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D025601:Adenomatous Polyposis Coli Protein; D003598:Cytoskeletal Proteins; D009363:Neoplasm Proteins