title: The manifold of vitamin B6 dependent enzymes.
abstract: Pyridoxal-5'-phosphate (vitamin B6) binding enzymes form a large superfamily that contains at least five different folds. The availability of an increasing number of known three-dimensional structures for members of this superfamily has allowed a detailed structural classification. Most progress has been made with the fold type I or aspartate aminotransferase family.
authors.affiliation: Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, S-171 77, Sweden. gunter@alfa.mbb.ki.se
authors.forename: G
authors.initials: G
authors.lastname: Schneider
authors.forename: H
authors.initials: H
authors.lastname: Käck
authors.forename: Y
authors.initials: Y
authors.lastname: Lindqvist
mesh_terms: D000411:Alanine Racemase / Q000737:chemistry / Q000378:metabolism; D000410:Alanine Transaminase / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000737:chemistry / Q000378:metabolism; D051263:D-Alanine Transaminase; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D006005:Phosphorylases / Q000737:chemistry / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011736:Pyridoxine / Q000378:metabolism*; D014367:Tryptophan Synthase / Q000737:chemistry / Q000378:metabolism
chemical_list: D004798:Enzymes; D006005:Phosphorylases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D051263:D-Alanine Transaminase; D014367:Tryptophan Synthase; D000411:Alanine Racemase; D011736:Pyridoxine