Memory enhancement for emotional stimuli is impaired in early Alzheimer's disease.
Emotional arousal is associated with enhanced memory in neurologically intact individuals, but it is unknown whether this effect is obtained in Alzheimer's disease (AD). The current study compared emotional memory and emotional reactions in patients with early AD and in older controls. Participants viewed emotionally arousing (both pleasant and unpleasant) and neutral photographs while cognitive and electrophysiological reactions were assessed. Memory was tested by free recall and recognition. Emotional reactions were normal in the AD group, but the emotional memory effect (enhanced memory for emotional vs. neutral stimuli) was impaired. Recall results indicated that this effect was normal for pleasant stimuli but abnormal for unpleasant stimuli. These results suggest that the neural basis for the emotional memory effect may be disrupted in AD. Findings are discussed in terms of the role of the amygdala in mediating emotional memory.
Hamann
S B
SB
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA. shamann@emory.edu
Monarch
E S
ES
Goldstein
F C
FC
D000339:Affect / Q000502:physiology*; D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D000679:Amygdala / Q000502:physiology; D001143:Arousal / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis*; D011939:Mental Recall / Q000502:physiology; D012720:Severity of Illness Index