title: Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells.
abstract: OBJECTIVE
  To study actions of allitridi extracted from garlic on intracellular calcium in isolated rat brain cells.
  
  
  METHODS
  Brain cells were isolated from newborn rat brain with Fura 2-AM measurements of intracellular Ca2+ concentration ([Ca2+]i).
  
  
  RESULTS
  Allitridi 1-100 mumol.L-1 concentration-dependently blocked increases of [Ca2+]i caused by potassium chloride and sodium glutamate (Glu) with IC50 of 59.7 and 69.9 mumol.L-1 respectively. Allitridi 100 mumol.L-1 blocked norepinephrine (Nor)-induced [Ca2+]i elevation.
  
  
  CONCLUSIONS
  Allitridi is an effective agent for blocking the [Ca2+]i increase caused by potassium chloride, Nor and Glu.
authors.affiliation: Department of Pharmacology, Nanjing Medical University, China.
authors.forename: X H
authors.initials: XH
authors.lastname: Ma
authors.forename: X X
authors.initials: XX
authors.lastname: Pan
authors.forename: T P
authors.initials: TP
authors.lastname: Liu
mesh_terms: D000498:Allyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002469:Cell Separation; D005737:Garlic / Q000737:chemistry*; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D010946:Plants, Medicinal; D011189:Potassium Chloride / Q000037:antagonists & inhibitors; D051381:Rats; D017207:Rats, Sprague-Dawley; D012970:Sodium Glutamate / Q000037:antagonists & inhibitors; D013440:Sulfides / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D013440:Sulfides; C042577:diallyl trisulfide; D011189:Potassium Chloride; D002118:Calcium; D012970:Sodium Glutamate; D009638:Norepinephrine