title: Evaluation of a computer-based decision support system for treatment of hypertension with drugs: retrospective, nonintervention testing of cost and guideline adherence.
abstract: OBJECTIVE
  To evaluate a computerized decision support system (DSS) for drug treatment of hypertension, regarding quality, safety, and cost compared to actual antihypertensive drug treatment.
  
  
  METHODS
  The medical profiles of 338 hypertensive patients treated with drugs against hypertension were processed by the DSS. The drug treatment proposed by the system was then compared to actual treatment given by their physician.
  
  
  METHODS
  Four health centres in the county of Västerbotten, in Sweden.
  
  
  METHODS
  A list of hypertensive patients was extracted from the computerized medical records of each health centre and every fifth patient's medical profile was assessed by the system.
  
  
  METHODS
  None.
  
  
  METHODS
  Drug used, drug used in relation to certain major diseases such as diabetes mellitus, asthma, ischaemic heart disease (IHD), and previous myocardial infarction. Adherence to hypertension guidelines, safety, and cost.
  
  
  RESULTS
  The DSS suggested significantly more thiazides and significantly fewer calcium antagonists than the physicians had prescribed, with a total cost reduction of 33-40%, depending on doses chosen. The DSS drug profile was more adherent to guidelines in patients with major complicating diseases, suggesting an improvement in treatment quality for these patients by the DSS.
  
  
  CONCLUSIONS
  The DSS which fully implements current guidelines may improve the quality of antihypertensive treatment, concurrently leading to a considerable reduction in drug costs.
authors.affiliation: Department of Public Health, University of Umeâ, Department of Pharmacology, Sweden. mats.persson@fammed.umu.se
authors.forename: M
authors.initials: M
authors.lastname: Persson
authors.forename: T
authors.initials: T
authors.lastname: Mjörndal
authors.forename: B
authors.initials: B
authors.lastname: Carlberg
authors.forename: J
authors.initials: J
authors.lastname: Bohlin
authors.forename: L H
authors.initials: LH
authors.lastname: Lindholm
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000191:economics* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D017046:Cost Savings; D003362:Cost-Benefit Analysis; D003658:Decision Making, Computer-Assisted; D020000:Decision Support Systems, Clinical; D016527:Drug Costs; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000191:economics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013548:Sweden; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents