[Dependence of the protective effect of the elevated sodium level on the type of oxidative substrate in the isolated heart during "calcium paradox"].
Isolated guinea pig heart were perfused with the Tyrode solution followed in 15 min. by a 10-min. Ca(2+)-free solution with subsequent return to the normal Ca(2+)-containing Tyrode solution. Sarcolemma damage was measured by myoglobin release. The perfusion resulted in damage of the myocardium cells. The data obtained show that elevation of the extracellular pressure during reperfusion with the Ca(2+)-containing medium is more important than the absolute value of the osmotic pressure.
Chapman
R A
RA
School of Veterinary Science, Bristol University, Great Britain.
Alabovskiĭ
V V
VV
Vinokurov
A A
AA
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D015428:Myocardial Reperfusion Injury / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D009997:Osmotic Pressure; D010084:Oxidation-Reduction; D019289:Pyruvic Acid / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D012965:Sodium Chloride / Q000494:pharmacology
D009211:Myoglobin; D012965:Sodium Chloride; D019289:Pyruvic Acid; D012964:Sodium; D005947:Glucose; D002118:Calcium