[The effect of scopolamine on the spatial organization of rat cortical potentials].
The influence of scopolamine (1 mg/kg, i.p.) on the spatial organization of the neocortical electrical activity was studied in rats. A decrease in the spectral power and coherence of brain potentials in the range of the dominant theta-rhythm peak (6.00-7.25 Hz) and their increase in the adjacent low-frequency band were observed. Both indices were decreased in the wide beta band (19.00-30.00 Hz). The described changes took place over the whole areas of the right hemisphere and parieto-temporal region of the left hemisphere. The obtained results are discussed with respect to the role of the cholinergic brain system in the higher nervous activity.
Koshtoiants
O Kh
OKh
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Korol'kova
T A
TA
Kozhechkin
S N
SN
Kozhedub
R G
RG
Sviderskaia
N E
NE
Petukhova
E G
EG
Balashova
A N
AN
D000818:Animals; D001931:Brain Mapping / Q000295:instrumentation / Q000379:methods; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology*; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D013997:Time Factors
D018727:Muscarinic Antagonists; D012601:Scopolamine