[Bilateral renal agenesis (Potter's syndrome) in a girl born to a hyperthyroid mother who received methimazole in early pregnancy].
Bilateral kidney agenesias (Potter syndrome) in a newborn of a hyperthyroid woman receiving methimazole during early pregnancy. This is a clinical case of a hyperthyroid woman that received methimazole during early pregnancy who gave birth to a girl with bilateral kidney agenesis. The initial clinical data was the presence of oligohydramnios detected by an ultrasound (US) at 19 gestational weeks. Another US at the term of the gestation showed anhydramnios, absence of renal silhouettes and bladder, which was corroborated when the girl was born. She died two days after she was born. Sufficient evidence exists that the methimazole administered during the early pregnancy can cause diverse congenital malformations including Potter's syndrome.
Rodríguez-García
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Servicio de Pediatría, Hospital General de Zona No. 32, Instituto Mexicano del Seguro Social, Minatítlán, Veracruz, México.
D000015:Abnormalities, Multiple / Q000139:chemically induced*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005145:Face / Q000002:abnormalities*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D008713:Methimazole / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D013577:Syndrome
D013956:Antithyroid Agents; D008713:Methimazole