Small diameter vascular prosthesis with a nonthrombogenic phospholipid polymer surface: preliminary study of a new concept for functioning in the absence of pseudo- or neointima formation.
The purpose of this study was to prepare a small diameter vascular prosthesis functioning without pseudointima formation. A nonthrombogenic phospholipid polymer, the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, has a cell membrane-like structure and has demonstrated strong nonthrombogenicity. We have recently prepared 2 kinds of vascular prostheses, 2 mm in diameter, composed of the MPC polymer and segmented polyurethane (SPU). One includes 7.5 wt% MPC polymer (SPU/MPC[7.5] prosthesis), and the other includes 10.0 wt% (SPU/MPC[10] prosthesis). These prostheses were placed in rabbit carotid arteries and were retrieved at 1 and 4 weeks after implantation. A pseudointima was observed at 4 weeks on the SPU/MPC(7.5). For the SPU/MPC(10), the surface was macroscopically clear without a pseudointima even after a 4 week implantation. It appears that the SPU/MPC(10) prosthesis, functioning without a pseudointima, possesses a stronger nonthrombogenicity and would be more applicable for clinical use.
Yoneyama
T
T
The Second Department of Surgery, Tokyo Medical and Dental University School of Medicine, Japan. YoneyamaT@aol.com
Ito
M
M
Sugihara
K
K
Ishihara
K
K
Nakabayashi
N
N
D000714:Anastomosis, Surgical; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D005337:Fibrin / Q000648:ultrastructure; D005500:Follow-Up Studies; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D011474:Prosthesis Design; D011817:Rabbits; D013499:Surface Properties; D013927:Thrombosis / Q000473:pathology*; D017539:Tunica Intima / Q000473:pathology*; D014654:Vascular Patency
D001672:Biocompatible Materials; D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D011108:Polymers; D011140:Polyurethanes; D010767:Phosphorylcholine; C079200:poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate); D005337:Fibrin