title: Nasogastric feeding enhances nutritional status in paediatric liver disease but does not alter circulating levels of IGF-I and IGF binding proteins.
abstract: OBJECTIVE
  Complications of childhood cirrhosis include abnormal growth and malnutrition, associated with abnormalities in circulating IGFs and IGFBPs. Controlled studies suggest that intensive enteral feeding enhances nutritional status. The aim was to ascertain whether nasogastric feeding improves nutritional status in clinical practice and to assess the effect of feeding on serum IGF-I and IGFBPs.
  
  
  METHODS
  Thirty-three children (median age 0.6 years) with biliary atresia and failure to thrive who were treated with nasogastric feeding.
  
  
  METHODS
  Height, weight and triceps skin fold thickness were measured prior to feeding and regularly for 1 year or until feeding was stopped. Serum IGF-I and IGFBPs were measured by immunoassay at the same intervals.
  
  
  RESULTS
  The median duration of feeding was 3.7 months. Twenty-two stopped feeding after liver transplantation, while 10 stopped electively and 1 boy died. Before feeding, the children were losing weight and height centile. Triceps skin fold thickness, weight and height SD scores improved with feeding. Baseline serum IGF-I and IGFBP-3 were low, while IGFBP-1 and IGFBP-2 were raised. IGF-I and IGFBP-1 did not change with feeding. IGFBP-2 fell and reached a nadir by 3 months, while IGFBP-3 rose temporarily for 4-6 weeks.
  
  
  CONCLUSIONS
  Nasogastric feeding improves body composition in paediatric liver disease but circulating IGF-I and IGFBPs remain abnormal and do not play a major role in mediating these changes. This does not exclude a paracrine or autocrine effect of IGF-I.
authors.affiliation: Department of Medicine, Child Health, King's College School of Medicine and Dentistry, London, UK. richard.holt@gstt.sthames.nhs.uk
authors.forename: R I
authors.initials: RI
authors.lastname: Holt
authors.forename: J P
authors.initials: JP
authors.lastname: Miell
authors.forename: J S
authors.initials: JS
authors.lastname: Jones
authors.forename: G
authors.initials: G
authors.lastname: Mieli-Vergani
authors.forename: A J
authors.initials: AJ
authors.lastname: Baker
mesh_terms: D001656:Biliary Atresia / Q000097:blood* / Q000628:therapy; D001823:Body Composition; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D009752:Nutritional Status; D010288:Parenteral Nutrition
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I