title: Testicular germ cell tumors in prepubertal children.
abstract: Pediatric testicular germ cell tumors are rare. Fifteen children, all less than 5 years of age, were evaluated and treated during February 1987 to July 1996. The median age was 18 months (range, 4-60 months). All were staged according to the Pediatric Oncology Group/Children's Cancer Study Group staging system. Seven patients had stage III disease. Histologically, 9 patients had pure endodermal sinus tumor, 1 had endodermal sinus tumor with embryonal carcinoma, 1 had embryonal carcinoma alone, 2 had immature teratoma, and 2 had mature teratoma. Six children were kept on surveillance. All others received chemotherapy with cisplatin, bleomycin, and vinblastine. The 10-year actuarial overall survival rate was 86.7%.
authors.affiliation: Division of Paediatric Oncology, Medical College, Trivandrum, India. rcctvm@md2.vsnl.net.in
authors.forename: P
authors.initials: P
authors.lastname: Kusumakumary
authors.forename: B S
authors.initials: BS
authors.lastname: Mathew
authors.forename: S
authors.initials: S
authors.lastname: Hariharan
authors.forename: T
authors.initials: T
authors.lastname: Priyakumari
authors.forename: B
authors.initials: B
authors.lastname: Rajan
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000627:therapeutic use; D002675:Child, Preschool; D002945:Cisplatin / Q000627:therapeutic use; D018237:Germinoma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D016019:Survival Analysis; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014747:Vinblastine; D002945:Cisplatin