title: Structural energetics of protein folding and binding.
abstract: Structural energetics is a method for calculating the energetics of protein folding and binding reactions as a function of temperature. This approach allows measured energetics to be interpreted with regards to the protein structure and the prediction of energetics from known structures. Recent advances include improvements in the parameterization of enthalpy, entropy and heat capacity terms and new applications, especially with regards to understanding dynamic properties of proteins and how these are affected by ligand binding.
authors.affiliation: Department of Biochemistry, University of lowa, lowa City, IA 52246, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Edgcomb
authors.forename: K P
authors.initials: KP
authors.lastname: Murphy
mesh_terms: D000577:Amides / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D000577:Amides; D046911:Macromolecular Substances; D011506:Proteins