Urinary concentration of corticoids in ponies with hyperlipoproteinaemia or hyperadrenocorticism.
The urinary corticoid:creatinine (c:c) ratio was determined in ten pony mares suffering from hyperlipoproteinaemia. The mean (+/- sd) urinary c:c ratio of these ten ponies (47 +/- 31 x 10(-6)) was not significantly different from that of twelve pony mares with a pituitary pars intermedia adenoma (31 +/- 18 x 10(-6). The correlation between the urinary concentration of corticoids and plasma total lipids, and the correlation between the urinary c:c ratio and plasma total lipids in ponies with hyperlipoproteinaemia were not significant (P > 0.05; r = 0.53 and r = 0.008, respectively). Preliminary results favour primary hyperadrenocorticism being associated with hyperlipoproteinaemia. In conclusion, the data presented here suggest that cortisol can contribute to insulin resistance in ponies with hyperlipoproteinaemia.
van der Kolk
J H
JH
Department of Large Animal Medicine and Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Wensing
T
T
D000305:Adrenal Cortex Hormones / Q000652:urine*; D000308:Adrenocortical Hyperfunction / Q000150:complications / Q000662:veterinary*; D000818:Animals; D003404:Creatinine / Q000652:urine*; D005260:Female; D006734:Horse Diseases / Q000503:physiopathology*; D006736:Horses; D006854:Hydrocortisone / Q000494:pharmacology; D006951:Hyperlipoproteinemias / Q000150:complications / Q000662:veterinary*; D007333:Insulin Resistance
D000305:Adrenal Cortex Hormones; D003404:Creatinine; D006854:Hydrocortisone