[Changes of plasma endothelin-1 in patients with congestive heart failure and the influence of metoprolol].
To investigate the alterations of plasma endothelin-1(ET-1) in patients with congestive heart failure(CHF) and the effects of metoprolol on it, plasma ET-1 and norepinephrine(NE) were measured in 43 patients using radioimmunoassay and high-performance liquid chromatography methods. Twenty-four patients were treated with metoprolol plus the routine therapy while the others were received the routine therapy only. The findings were that levels of plasma ET-1 and NE increased before the treatment, and decreased after the treatment with metoprolol for 1 month. There was no alteration of plasma ET-1 or NE in the control group.
Xu
H
H
Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Sun
M
M
Zhou
H
H
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood
D000319:Adrenergic beta-Antagonists; D019332:Endothelin-1; D008790:Metoprolol; D009638:Norepinephrine