title: Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity.
abstract: 8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against A beta-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.
authors.affiliation: College of Pharmacy, Seoul National University, South Korea.
authors.forename: S S
authors.initials: SS
authors.lastname: Jew
authors.forename: C H
authors.initials: CH
authors.lastname: Yoo
authors.forename: D Y
authors.initials: DY
authors.lastname: Lim
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: I
authors.initials: I
authors.lastname: Mook-Jung
authors.forename: M W
authors.initials: MW
authors.lastname: Jung
authors.forename: H
authors.initials: H
authors.lastname: Choi
authors.forename: Y H
authors.initials: YH
authors.lastname: Jung
authors.forename: H
authors.initials: H
authors.lastname: Kim
authors.forename: H G
authors.initials: HG
authors.lastname: Park
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D053978:Pentacyclic Triterpenes; D010446:Peptide Fragments; D014315:Triterpenes; C074636:amyloid beta-protein (25-35); C017032:asiatic acid