Bile acids are physiological ligands for a nuclear receptor.
Bile acids are essential for the solubilization and transport of dietary lipids and are the major products of cholesterol catabolism. Results presented here show that bile acids are physiological ligands for the farnesoid X receptor (FXR), an orphan nuclear receptor. When bound to bile acids, FXR repressed transcription of the gene encoding cholesterol 7 alpha-hydroxylase, which is the rate-limiting enzyme in bile acid synthesis, and activated the gene encoding intestinal bile acid-binding protein, which is a candidate bile acid transporter. These results demonstrate a mechanism by which bile acids transcriptionally regulate their biosynthesis and enterohepatic transport.
Walters
J R
JR
Gastroenterology Section Division of Medicine Imperial College School of Medicine Hammersmith Hospital, London W12 0NN, UK. julian.walters@ic.ac.uk.
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology*; D006801:Humans; D008024:Ligands; D051379:Mice; D011817:Rabbits; D051381:Rats; D014158:Transcription, Genetic
D001647:Bile Acids and Salts; D008024:Ligands