[Effect of ischemia/reperfusion in cardiac surgery with cardiopulmonary bypass on nitric oxide levels of peripheral blood in patients].
To examine the effect of ischemia/reperfusion in cardiac surgery with cardiopulmonary bypass (CPB) on nitric oxide (NO) levels of peripheral blood, venous levels of NO2- and NO3- were measured at multiple time-points before, during, and after CPB by means of high-pressure liquid chromatograph to reflect NO concentration indirectly in 20 patients. The results showed there was a linear regression between the decreased trend of NO release at the period of peri-CPB is related to the endothelial cell activation caused by ischemia/reperfusion at the same time. Therefore it is necessary to explore the regulation and action of NO release during systemic inflammatory response procedure in CPB.
Xiao
X
X
Division of Cardiothoracic Surgery, First Affiliated Hospital, Changdu.
Liang
M
M
Yu
Q
Q
Huang
Y
Y
Zhou
P
P
Zhang
X
X
Zeng
W
W
Tian
Z
Z
D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000097:blood* / Q000209:etiology; D009569:Nitric Oxide / Q000097:blood*
D009569:Nitric Oxide