title: Marathon with cystic fibrosis and bilateral lung transplant.
abstract: The article presents studies performed before, during and after a marathon run (42,195 m) in a 32-year-old man who underwent a bilateral lung transplantation because of end-stage cystic fibrosis (CF) 15 months prior to the race. Before the run his FEV1 was 81% predicted, compared with 19% predicted before the operation, and his maximal oxygen uptake was 31.9 ml/kg(-1)/min(-1). He completed the New York City Marathon 1998 without major problems in 7 h 8 min 50s. Pulmonary tests, biochemical changes and endocrine responses indicated transient changes, mostly as expected in healthy marathon runners. The case demonstrates that physiological trainability and psychological will power following a successful bilateral lung transplantation can transform a chronically ill CF patient into a robust marathon runner.
authors.affiliation: Sunnaas Rehabilitation Hospital, Nesoddtangen, Norway.
authors.forename: J K
authors.initials: JK
authors.lastname: Stanghelle
authors.forename: J O
authors.initials: JO
authors.lastname: Koss
authors.forename: O
authors.initials: O
authors.lastname: Bjørtuft
authors.forename: O
authors.initials: O
authors.lastname: Geiran
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000097:blood; D003550:Cystic Fibrosis / Q000503:physiopathology / Q000601:surgery*; D005541:Forced Expiratory Volume; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D016040:Lung Transplantation; D008297:Male; D012420:Running / Q000502:physiology; D014527:Uric Acid / Q000097:blood
chemical_list: D014527:Uric Acid; D003402:Creatine Kinase; D006854:Hydrocortisone