title: Western diet, family history of colorectal cancer, NAT2, GSTM-1 and risk of colon cancer.
abstract: OBJECTIVE
  In this study we examine the combined effects of Western diet, age at diagnosis, and genetic susceptibility.
  
  
  METHODS
  We use data collected as part of an incident case-control study of colon cancer. Family history of colorectal cancer, N-acetyltransferase (NAT2), and glutathione-S-transferase (GSTM-1) are studied with Western diet and age at diagnosis.
  
  
  RESULTS
  A significant interaction between age at time of diagnosis, Western dietary pattern, and family history of colorectal cancer (p for interaction = 0.03) was detected. Those with a family history of colorectal cancer who ate a predominantly Western diet were at increased risk of colon cancer (OR 14.0, 95% CI 3.9-50.1 for < or = 55 years; OR 7.7, 95% CI 2.0-29.1 for 56-66 years; OR 1.6, 95% CI 0.8-3.2 for > or = 67 years) compared to those without a family history of colorectal cancer and low levels of a Western diet. Associations with the Western diet were stronger than individual components of the dietary pattern. Neither NAT2 nor GSTM-1 showed significant interaction with Western diet.
  
  
  CONCLUSIONS
  The extent to which diet comprising a Western dietary pattern influences risk of colon cancer is dependent on age. This dietary pattern also appears to modulate the colon cancer risk associated with a family history of colon cancer.
authors.affiliation: Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Slattery
authors.forename: J D
authors.initials: JD
authors.lastname: Potter
authors.forename: K N
authors.initials: KN
authors.lastname: Ma
authors.forename: B J
authors.initials: BJ
authors.lastname: Caan
authors.forename: M
authors.initials: M
authors.lastname: Leppert
authors.forename: W
authors.initials: W
authors.lastname: Samowitz
mesh_terms: D017668:Age of Onset; D000368:Aged; D001191:Arylamine N-Acetyltransferase / Q000032:analysis / Q000378:metabolism; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000209:etiology* / Q000235:genetics*; D004032:Diet; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D012737:Sex Factors
chemical_list: D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase