Dolastatin 3 and two novel cyclic peptides from a palauan collection of Lyngbya majuscula.
A collection of Lyngbya majuscula from Palau contained the peptides dolastatin 3 (1), homodolastatin 3 (2), and kororamide (3), together with aplysiatoxin (4), debromoaplysiatoxin (5), and oscillatoxin A (6). The structures of the new peptides homodolastatin 3 (2) and kororamide (3) were determined by interpretation of spectroscopic data and chemical degradation.
Mitchell
S S
SS
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
Faulkner
D J
DJ
Rubins
K
K
Bushman
F D
FD
D000596:Amino Acids / Q000032:analysis; D047630:Depsipeptides; D008401:Gas Chromatography-Mass Spectrometry; D019428:HIV Integrase Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D019029:Palau; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000596:Amino Acids; D047630:Depsipeptides; D019428:HIV Integrase Inhibitors; D010456:Peptides, Cyclic; C406773:dolastatin 3; C406775:homodolastatin 3; C406774:kororamide