[Study on the effects of hyaluronic acid-streptomycin perfusion through the round window on the function and morphology in guinea pig inner ears].
To investigate the effects of the hyaluronic acid-streptomycin (HA-SM) perfusion through round window on the function and morphology of the inner ear in guinea pig, membrous labyrinth mapping, temporal bone section after celloidin embedding, transmission electron microscopy, electrocochlegraphy (ECochG) and electronystagmography (ENG) were examined. The nystagmus duration induced by caloric test was obviously reduced in comparison with that of the preoperation (P< 0.01), while the action potential(AP) by ECochG was not obviously changed. The sensory cells of estibular organs were severely damaged, while the morphology of corti's organs were significantly damaged after HA-SM perfusion. The results suggest that the HA-SM perfusion through the round window may selectively destroy the vestibular function, whereas the auditory function is not obviously damaged.
Yin
T
T
Department of Otolaryngology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Lu
Y
Y
Chen
Z
Z
Ren
J
J
Xie
D
D
Yang
X
X
Tan
W
W
Zhu
D
D
D000818:Animals; D001300:Audiometry, Evoked Response; D007758:Ear, Inner / Q000503:physiopathology* / Q000648:ultrastructure; D004584:Electronystagmography; D005072:Evoked Potentials, Auditory; D005260:Female; D006168:Guinea Pigs; D006820:Hyaluronic Acid; D008297:Male; D009925:Organ of Corti / Q000648:ultrastructure; D012405:Round Window, Ear; D013307:Streptomycin; D014724:Vestibular Function Tests
D006820:Hyaluronic Acid; D013307:Streptomycin