Antiviral effect of flavonoids on the dengue virus.
In the present study we analysed the possible antiviral effect on dengue viruses of different flavonoids extracted and identified at the Chemistry Institute, UNAM, from the Mexican plants Tephrosia madrensis, Tephrosia viridiflora and Tephrosia crassifolia. The flavonoids glabranine and 7-O-methyl-glabranine presented 70% inhibition on the dengue virus at a concentration of 25 microM, while methyl-hildgardtol A, hildgardtol A and elongatine had no effect on viral growth. Our results show that glabranine and 7-O-methyl-glabranine isolated from Tephrosia s.p. exert a dose-dependent inhibitory effect in vitro on the dengue virus.
Sánchez
I
I
Instituto de Investigaciones Biomédicas, UNAM, Depto. de Biología Molecular, Circuito Interior, Ciudad Universitaria, 04510 México, D. F, México.
Gómez-Garibay
F
F
Taboada
J
J
Ruiz
B H
BH
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003716:Dengue Virus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology* / Q000633:toxicity; D008253:Macaca mulatta
D000998:Antiviral Agents; D005419:Flavonoids