title: mtDNA A3243G MELAS mutation is not associated with multigenerational female migraine.
abstract: The authors searched for mitochondrial DNA (mtDNA) A3243G mutation in peripheral blood leukocytes from female migraine patients with pure matrilinear history of migraine along two or three generations. The current study was designed to exclude any male transmission of the disease. The mutation was absent in all patients. We conclude that mtDNA A3243G mutation does not contribute to the pathogenesis of pure matrilinear multigenerational migraine with or without aura.
authors.affiliation: IRCCS Neuromed, Pozzilli, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Buzzi
authors.forename: G
authors.initials: G
authors.lastname: Di Gennaro
authors.forename: M
authors.initials: M
authors.lastname: D'Onofrio
authors.forename: O
authors.initials: O
authors.lastname: Ciccarelli
authors.forename: F M
authors.initials: FM
authors.lastname: Santorelli
authors.forename: D
authors.initials: D
authors.lastname: Fortini
authors.forename: G
authors.initials: G
authors.lastname: Nappi
authors.forename: F
authors.initials: F
authors.lastname: Nicoletti
authors.forename: C
authors.initials: C
authors.lastname: Casali
mesh_terms: D000328:Adult; D000368:Aged; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006801:Humans; D017241:MELAS Syndrome / Q000150:complications* / Q000235:genetics*; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications* / Q000235:genetics*; D009154:Mutation / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial