[An endometrium morphometry study on ovariectomized rats subjected to nilestriol and estradiol replalcement therapies].
This study was designed to evaluate the effect of estrogen on rat endometrium and compare the results of Nilestriol and Estradiol replacement therapies for preventing osteoporosis in ovariectomized rats. Forty 4-month old SD female rats were randomly divided into four groups, namely sham operation, bilateral ovariectomy, ovariectomy plus supplementary ethinyl estradiol (0.2 microgram/100 g B. W. qd x 5), and ovariectomy plus supplementary Nilestriol (0.15 mg/100 g B. W. once a week). Computerized image analyzer was used to evaluate the endomitrial pathological changes 10 weeks later. The results showed an atrophied endometrium in ovariectomized group, a slightly proliferative endometrium in Nilestriol treated group, and a markedly proliferative endometrium with local atypical hyperplasia in estradiol treated group. The difference between group 3 and group 4 in morphometry was significant (P < 0.5). These suggest the relative safety of Nilestriol replacement therapy for preventing menopausal osteoporosis.
Xu
K
K
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chengdu.
Liu
H
H
Bi
S
S
Yang
S
S
Tan
J
J
D000818:Animals; D004717:Endometrium / Q000473:pathology*; D004958:Estradiol / Q000627:therapeutic use*; D004964:Estriol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007091:Image Processing, Computer-Assisted; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000473:pathology*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D004958:Estradiol; D004964:Estriol