Chromosome 22q11 deletions are not found in autistic patients identified using strict diagnostic criteria. IMGSAC. International Molecular Genetics Study of Autism Consortium.
A group of 103 subjects with a strict diagnosis of autism were tested for deletion of band q11.2 on the long arm of chromosome 22. No deletions were found, indicating that when a patient has been diagnosed with autism using strict and consistent criteria, in the absence of other indications, it is unlikely that this individual will have a 22q11 deletion. Testing for 22q11 deletions is therefore unlikely to be necessary in these patients. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:15-17, 2000.
Ogilvie
C M
CM
Department of Cytogenetics, Division of Medical and Molecular Genetics, Guy's and St. Thomas' Hospital, London. c.ogilvie@umds.ac.uk
Moore
J
J
Daker
M
M
Palferman
S
S
Docherty
Z
Z
D000293:Adolescent; D001321:Autistic Disorder / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002872:Chromosome Deletion; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male