title: Antidepressant options in primary care.
abstract: This article summarizes the basic and clinical pharmacology of the available antidepressants to aid the busy primary care practitioner in anticipating and predicting the effects of different antidepressants on patients; choosing a specific antidepressant for each patient based on these effects; selecting a sequential antidepressant for the patient who has not benefited from a trial of a specific type of antidepressant, either because of inadequate effect or treatment-limiting adverse effects; and avoiding adverse drug interactions when choosing an antidepressant for patients on other drug therapy.
authors.affiliation: Department of Psychiatry, University of Kansas School of Medicine, Wichita, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Preskorn
mesh_terms: D000928:Antidepressive Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy*; D004341:Drug Evaluation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D011320:Primary Health Care; D013375:Substance Withdrawal Syndrome / Q000473:pathology
chemical_list: D000928:Antidepressive Agents; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System