Vitamin D receptor genotype and breast cancer in Latinas (United States).
OBJECTIVE
Polymorphism in the vitamin D receptor (VDR) gene has been associated with variation in bone mineral density and with prostate cancer risk. The purpose of this study was to determine whether polymorphism in the VDR gene may also influence breast cancer risk.


METHODS
Polymorphisms in the 5' and 3' ends of the VDR gene were genotyped for 143 Latina women with breast cancer and 300 cohort controls.


RESULTS
Both the BsmI and poly-A polymorphisms in the 3' end of the VDR gene were associated with breast cancer risk, with a trend for increasing risk with increasing number of BsmI B alleles or short (S) poly-A alleles. Compared to subjects having two long poly-A alleles (genotype LL), odds ratios (and 95% confidence intervals) were 1.5 (1.0 2.3) and 3.2 (1.5-6.9) for subjects having genotypes SL and SS, respectively. Compared to BsmI genotype bb, odds ratios (and 95% confidence intervals) were 1.6 (1.1-2.5) and 2.2 (1.0-4.7) for genotypes Bb and BB respectively. The start codon polymorphism, FokI, was not associated with breast cancer risk.


CONCLUSIONS
These results suggest that polymorphic variation in or near the 3' end of the VDR gene influences breast cancer risk in Latina women.
Ingles
S A
SA
Department of Preventive Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles 90033, USA. ingles@hsc.usc.edu
Garcia
D G
DG
Wang
W
W
Nieters
A
A
Henderson
B E
BE
Kolonel
L N
LN
Haile
R W
RW
Coetzee
G A
GA
D000368:Aged; D001943:Breast Neoplasms / Q000208:ethnology* / Q000235:genetics*; D002140:California / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D014644:Genetic Variation; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D018167:Receptors, Calcitriol / Q000235:genetics*; D018570:Risk Assessment
D018167:Receptors, Calcitriol