Lack of association between ACE gene polymorphism and left ventricular hypertrophy in essential hypertension.
The possible association between the insertion/deletion (I/D) polymorphism of the angiotensin I converting enzyme (ACE) gene and left ventricular hypertrophy (LVH) was investigated in a group of essential hypertensive patients. Seventy-one essential hypertensive patients (35 men and 36 women), aged 51 +/- 1 years, were genotyped by PCR for the I/D polymorphism of the ACE gene. Cardiac morphology and function were assessed by means of M-mode echocardiography. The relative frequencies of the three genotypes, DD, DI, and II, were respectively: 24%, 55%, and 21%. Mean values of left ventricular mass index were 145, 144, and 150 g/m2 for DD, DI, and II genotypes, without significant differences among them (P = 0.82). Likewise, the prevalence of LVH (76%, 64%, and 87%) was not significantly different among the three genotypes (P = 0.23). We conclude that the ACE gene I/D polymorphism is not associated with LVH in essential hypertension. Journal of Human Hypertension (2000) 14, 47-49.
Gomez-Angelats
E
E
Department of Internal Medicine, Hospital Clínic, Barcelona, Spain.
de la Sierra
A
A
Enjuto
M
M
Sierra
C
C
Oriola
J
J
Francino
A
A
Paré
J C
JC
Poch
E
E
Coca
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure; D003430:Cross-Sectional Studies; D004247:DNA / Q000235:genetics; D004251:DNA Transposable Elements; D004452:Echocardiography; D005260:Female; D017353:Gene Deletion; D005819:Genetic Markers; D005838:Genotype; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D013318:Stroke Volume
D004251:DNA Transposable Elements; D005819:Genetic Markers; D004247:DNA; D007703:Peptidyl-Dipeptidase A