New immunopharmacologic approaches to asthma: role of cytokine antagonism.
This article involves an elucidation of the potential inflammatory mechanisms associated with the treatment of allergic disease and asthma, and the possibility of cytokine antagonism as a potential therapeutic mechanism for the treatment of those diseases. There is a review of the role of cytokines in the allergic process and a description of a number of studies done with the capacity of certain cytokine antagonists to develop potential amelioration of immune dysregulation in asthma and atopic states.
Rosenwasser
L J
LJ
Division of Allergy and Clinical Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA.
D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D016207:Cytokines / Q000037:antagonists & inhibitors*; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation / Q000503:physiopathology; D007375:Interleukin-1 / Q000627:therapeutic use; D015847:Interleukin-4 / Q000627:therapeutic use; D008264:Macrophages / Q000502:physiology; D012137:Respiratory System / Q000503:physiopathology; D013601:T-Lymphocytes / Q000502:physiology
D016207:Cytokines; D007375:Interleukin-1; D015847:Interleukin-4