In vitro and in vivo antibacterial activities of biapenem in the fields of obstetrics and gynecology.
Biapenem is a new injectable carbapenem antibiotic which has favorable pharmacokinetic properties, and is stable to hydrolysis by dehydropeptidase I. Biapenem inhibited more than 90% of clinical isolates of Streptococcus agalactiae, Escherichia coli, Peptostreptococcus magnus, Bacteroides fragilis and Prevotella bivia at the concentration of 3.13 mg/l. The MIC(90) of biapenem against Pseudomonas aeruginosa was lower than that of panipenem, equivalent to that of imipenem, and greater than that of meropenem. The in vivo efficacy of biapenem was evaluated using the experimental infection model of uterine endometritis. The accumulation of neutrophils in the uterus in the biapenem- treated group was less marked than in the nontreated group, as well as bacteriological response. These results suggest that the new antimicrobial agent biapenem might be useful for the treatment of polymicrobial infections in the fields of obstetrics and gynecology.
Mikamo
H
H
Department of Obstetrics and Gynecology, School of Medicine, Gifu University, Gifu, Japan. mikamo@cc.gifu-u.ac.jp
Sato
Y
Y
Hayasaki
Y
Y
Tamaya
T
T
D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D004716:Endometritis / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D051381:Rats; D017207:Rats, Sprague-Dawley; D013845:Thienamycins / Q000494:pharmacology*; D014591:Uterine Diseases / Q000188:drug therapy* / Q000382:microbiology*
D013845:Thienamycins; C065257:biapenem