Pharmacoeconomics of therapeutic drug monitoring in transplantation.
Immunosuppressive drugs have contributed significantly to the success of organ transplantation. Therapeutic drug monitoring is an integral part of transplant protocols. However, there is little information concerning its positive contribution to pharmacoeconomics. Before developing studies to demonstrate the potential benefits of TDM, consideration must be given to the type of TDM to be evaluated. It is argued that, given that the lymphocyte in the central compartment is the target for immunosuppressants, Area-Under-the-Curve monitoring may be a better reflection of control and toxicity than traditional trough monitoring.
Potter
J M
JM
Queensland Health Pathology Service, The Prince Charles Hospital, Brisbane, Australia.
D019540:Area Under Curve; D016903:Drug Monitoring / Q000191:economics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000191:economics* / Q000493:pharmacokinetics*; D014180:Transplantation / Q000191:economics*
D007166:Immunosuppressive Agents