Preparation of microcapsules for skin allergy testing by the solvent evaporation process.
Polyurethanes and polyvinyl alcohol modified by stearyl isocyanate are used as a matrix for microparticles made by a solvent evaporation process to encapsulate allergenic molecules, with petrolatum used as a neutral vehicle. The encapsulation yields, depending on the agent to be encapsulated, vary from 22 to 45%.
Brosse
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Chimie et Physique des Matériaux Polymères, UMR 6515 CNRS-Université du Maine, Le Mans, France.
Soutif
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JC
Brosse
J C
JC
D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D001566:Benzocaine / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism; D002214:Capsules / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D003485:Cyanates; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000276:immunology; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D000432:Methanol / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D010577:Petrolatum; D011140:Polyurethanes / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000031:analogs & derivatives / Q000737:chemistry; D012882:Skin Tests; D012995:Solubility; D012996:Solutions; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014867:Water / Q000378:metabolism
D000485:Allergens; D002214:Capsules; D003485:Cyanates; D011140:Polyurethanes; D012996:Solutions; D012997:Solvents; D014867:Water; D010577:Petrolatum; D011142:Polyvinyl Alcohol; C005057:isocyanic acid; D001566:Benzocaine; D000432:Methanol