[Dose the serum brain natriuretic peptide (BNP) level after open heart surgery reflect myocardial protection?].
This clinical study was conducted to determine whether the serum BNP level after open heart surgery reflects myocardial protection. The levels of BNP and CPK-MB were measured before and after 12 hours of cardiopulmonary bypass, then 1, 3, and 6 days after open heart surgery, and the relationship between the maximum levels of BNP and the CPK-MB after open heart surgery was examined. The patients were divided into two groups according to whether or not the maximum CPK MB was more than 100 IU/l after open heart surgery. A significant relationship between the maximum BNP and the maximum CPK-MB after open heart surgery was observed (p = 0.013). Moreover, the BNP was significantly increased in the group of patients with a maximum CPK-MB > or = 100 IU/l, compared to that in those with a maximum CPK-MB < 100 IU/l, 12 hours 1 day, and 6 days after open heart surgery (p < 0.01). These findings indicate that the serum level of BNP after open heart surgery can reflect myocardial protection.
Shirasawa
B
B
First Department of Surgery, Yamaguchi University School of Medicine, Ube, Japan.
Hamano
K
K
Kawamura
T
T
Gohra
H
H
Katoh
T
T
Fujimura
Y
Y
Zempo
N
N
Esato
K
K
D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006324:Heart Arrest, Induced; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011184:Postoperative Period
D007527:Isoenzymes; D020097:Natriuretic Peptide, Brain; D003402:Creatine Kinase