Chronic fatigue syndrome and/or fibromyalgia as a variation of antiphospholipid antibody syndrome: an explanatory model and approach to laboratory diagnosis.
Chronic Fatigue and/or Fibromyalgia have long been diseases without definition. An explanatory model of coagulation activation has been demonstrated through use of the ISAC panel of five tests, including, Fibrinogen, Prothrombin Fragment 1+2, Thrombin/ AntiThrombin Complexes, Soluble Fibrin Monomer, and Platelet Activation by flow cytometry. These tests show low level coagulation activation from immunoglobulins (Igs) as demonstrated by Anti-B2GPI antibodies, which allows classification of these diseases as a type of antiphospholipid antibody syndrome. The ISAC panel allows testing for diagnosis as well as monitoring for anticoagulation protocols in these patients.
Berg
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HEMEX Laboratories, Inc., Phoenix, Arizona 85021, USA.
Berg
L H
LH
Couvaras
J
J
Harrison
H
H
D016736:Antiphospholipid Syndrome / Q000145:classification / Q000175:diagnosis*; D019411:Clinical Laboratory Techniques; D003937:Diagnosis, Differential; D015673:Fatigue Syndrome, Chronic / Q000175:diagnosis*; D005356:Fibromyalgia / Q000175:diagnosis*; D006801:Humans