Relative abundance of placental pro-atrial natriuretic factor mRNA in normal pregnancy and pre-eclampsia.
Atrial natriuretic factor (ANF), produced by cytotrophoblast cells of the human placenta, may be involved in the regulation of uteroplacental blood flow. Pre-eclampsia is associated with maternal hypertension and reduced uteroplacental perfusion. The relationship between pre-eclampsia and placental production of ANF is not known. This study measured pro-ANF mRNA levels by Northern blot analysis in placentae delivered by caesarean section at preterm and term gestations from women with normotensive and pre-eclamptic pregnancies and found no significant difference between pre-eclampsia and normal pregnancy at either gestation. This result suggests that placental production of ANF is not altered at the pretranslational level during pre-eclampsia.
Gude
N M
NM
Department of Perinatal Medicine, Royal Women's Hospital, Carlton, Vic., Australia. nmgude@ariel.its.unimelb.edu.au
Stebbing
P N
PN
Wang
L
L
Xue
J
J
Brennecke
S P
SP
Lim
A T
AT
D000328:Adult; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000096:biosynthesis*; D001483:Base Sequence; D015152:Blotting, Northern; D002585:Cesarean Section; D005260:Female; D005865:Gestational Age; D006801:Humans; D008969:Molecular Sequence Data; D010920:Placenta / Q000737:chemistry*; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D011247:Pregnancy / Q000502:physiology*; D011256:Pregnancy Outcome; D011336:Probability; D011498:Protein Precursors / Q000032:analysis / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000032:analysis*; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
D011498:Protein Precursors; D012333:RNA, Messenger; D009320:Atrial Natriuretic Factor