Renin-producing hepatoblastoma.
Renin-producing tumors of extrarenal origin are rare in children. An 8-year-old boy with hepatoblastoma and hypertension associated with a high plasma renin level is reported. After chemotherapy, the plasma renin level normalized and the hypertension spontaneously resolved. The patient underwent surgery, and a right trisegmentectomy of the liver and a partial resection of the second and third segments were performed. The tumor was as shown the source of renin by immunohistochemical study and reverse transcriptase-polymerase chain reaction.
Moritake
H
H
The Department of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan.
Taketomi
A
A
Kamimura
S
S
Ikuno
Y
Y
Seo
Y
Y
Fukuda
T
T
Iguchi
H
H
Okamura
J
J
D002648:Child; D018197:Hepatoblastoma / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood; D008113:Liver Neoplasms / Q000097:blood / Q000378:metabolism*; D008297:Male; D012083:Renin / Q000096:biosynthesis* / Q000097:blood
D012083:Renin