Iodinated free fatty acid and 201T1 uptake in chronically hypoperfused myocardium: histologic correlation study.
123I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) is a tracer for the evaluation of ischemic heart disease. The purpose of this study was to assess the relationship between 1231-BMIPP uptake and myocardial fibrosis.


METHODS
Fifteen patients who underwent cardiac surgery were examined by imaging with 201TI and 123I-BMIPP, and histologic specimens were taken during surgery. The relative uptake of 201TI (%TI) and that of 123I-BMIPP (%BMIPP) were calculated. The percentage of fibrosis (%fibrosis) was analyzed with the specimen.


RESULTS
%TI correlated strongly with %fibrosis (r = -0.94; P < 0.001). %BMIPP also correlated significantly with %fibrosis (r = -0.88; P < 0.001), but the change in %BMIPP looked biphasic. In the category of only mild fibrosis, %BMIPP showed a steep decrease. 123I-BMIPP-201TI mismatch was found only for fibrosis <20%.


CONCLUSIONS
123I-BMIPP gave specific information about metabolic changes that occurred in ischemic myocardium without severe fibrotic changes.
Kudoh
T
T
Department of Nuclear Medicine and Diagnostic Imaging, School of Medicine, Kyoto University, Japan.
Tadamura
E
E
Tamaki
N
N
Hattori
N
N
Inubushi
M
M
Kubo
S
S
Magata
Y
Y
Nishimura
K
K
Matsuda
K
K
Konishi
J
J
D003327:Coronary Disease / Q000000981:diagnostic imaging; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D013794:Thallium Radioisotopes; C049338:iodofiltic acid