title: Quantifying the risks of hypertension, age, sex and smoking in patients with abdominal aortic aneurysm.
abstract: BACKGROUND
  The prevalence of abdominal aortic aneurysm (AAA) in a community-based sample of men and women aged 65-79 years was correlated with known risk factors. In addition, the effect of high blood pressure and the use of antihypertensive medication on growth of AAAs were studied.
  
  
  METHODS
  Aortic diameter was assessed by ultrasonography and data on risk factors were collected by self-administered questionnaire for 5356 men and women as part of a randomized controlled trial.
  
  
  RESULTS
  Current hypertension increased the risk of having an aortic aneurysm by 30-40 per cent while use of antihypertensive medication increased the risk by 70-80 per cent, adjusting for current blood pressure. There was no clear relationship between hypertension and growth rates of existing aneurysms in this study, although these results were largely from data on small aneurysms. Men were nearly six times more likely to develop an AAA than women; the risk increased by 40 per cent every 5 years after the age of 65 years. Smoking was an independent risk factor for AAA, with level of exposure being more significant than duration.
  
  
  CONCLUSIONS
  Male sex, smoking and hypertension are strong risk factors for the development of AAA. In this study hypertension did not significantly increase the growth rate of existing aneurysms. Smoking remains the most important avoidable risk factor for AAA. The analyses presented here suggest that selection for screening, other than by age and sex, is not worthwhile.
authors.affiliation: Clinical Effectiveness Unit, Royal College of Surgeons of England, London, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Vardulaki
authors.forename: N M
authors.initials: NM
authors.lastname: Walker
authors.forename: N E
authors.initials: NE
authors.lastname: Day
authors.forename: S W
authors.initials: SW
authors.lastname: Duffy
authors.forename: H A
authors.initials: HA
authors.lastname: Ashton
authors.forename: R A
authors.initials: RA
authors.lastname: Scott
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects*
chemical_list: D000959:Antihypertensive Agents