Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**
Replacing the ammonium polar head in cationic lipids 1 (A=N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.
Guénin
E
UMR CNRS 6521, Université de Bretagne Occidentale Département de Chimie 6, avenue Le Gorgeu, BP 809, 29285 Brest Cedex (France).
Hervé
AC
Floch
V
Loisel
S
Yaouanc
JJ
Clément
JC
Férec
C
des Abbayes H