Stimulation of memory T cells by cytokines.
Mature T cells can be classified on the basis of cell surface markers into naïve- and memory-phenotype cells. These phenotypically-defined subsets exhibit distinct kinetic behaviour in vivo. Thus, naïve-phenotype T cells persist long-term in a non-dividing state, while memory-phenotype T cells include cycling cells and have a more rapid rate of turnover. We have investigated the possibility that the different kinetic behaviour of naïve- and memory-phenotype T cells reflects a differential responsiveness to cytokines. It was discovered that memory-, but not naïve-, phenotype T cells were stimulated to proliferate by a variety of infection-induced cytokines. These results suggest that cytokines contribute to the high background rate of turnover exhibited by memory T cells.
Tough
D F
DF
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, UK. david.tough@jenner.ac.uk
Sun
S
S
Zhang
X
X
Sprent
J
J
D000818:Animals; D000941:Antigens; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D016207:Cytokines / Q000494:pharmacology*; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D007156:Immunologic Memory / Q000187:drug effects*; D007700:Kinetics; D008213:Lymphocyte Activation; D051379:Mice; D010641:Phenotype; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*
D000941:Antigens; D016207:Cytokines; D018960:Hyaluronan Receptors