title: Postirradiation morphea of the breast presentation of two cases and review of the literature.
abstract: The advent of radiation therapy as a common modality in the treatment and palliation of breast cancer has led to the observation of morphea developing months to years after supervoltage radiation therapy, in and around the site of treatment. We report 2 new cases of morphea at the site of previous supervoltage radiation therapy for breast cancer. The time period between irradiation and onset of morphea in our 2 patients were an atypically long 6.5 years and 32 years, the latter being the longest reported such interval. With conservative treatment, the inflammatory component of the lesions resolved over an approximately 1-year period, leaving residual sclerosis. These patients are compared to those previously reported in the medical literature so as to summarize the range of clinical presentation and course. Recognition of postirradiation morphea is important in distinguishing it from infectious cellulitis, recurrent carcinoma, metastatic carcinoma or development of a second primary carcinoma.
authors.affiliation: Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520-8059, USA.
authors.forename: J V
authors.initials: JV
authors.lastname: Schaffer
authors.forename: C
authors.initials: C
authors.lastname: Carroll
authors.forename: I
authors.initials: I
authors.lastname: Dvoretsky
authors.forename: M J
authors.initials: MJ
authors.lastname: Huether
authors.forename: M
authors.initials: M
authors.lastname: Girardi
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D012594:Scleroderma, Localized / Q000209:etiology*; D012867:Skin / Q000473:pathology / Q000528:radiation effects