title: Efficacy of SCH56592 in a rabbit model of invasive aspergillosis.
abstract: SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.
authors.affiliation: Departments of Medicine, San Antonio, Texas 78284, USA. KIRKPATRICK@UTHSCSA.EDU
authors.forename: W R
authors.initials: WR
authors.lastname: Kirkpatrick
authors.forename: R K
authors.initials: RK
authors.lastname: McAtee
authors.forename: A W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: D
authors.initials: D
authors.lastname: Loebenberg
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: T F
authors.initials: TF
authors.lastname: Patterson
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D001230:Aspergillus / Q000302:isolation & purification; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D005260:Female; D007165:Immunosuppression Therapy; D017964:Itraconazole / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; D017964:Itraconazole; C101425:posaconazole; D000666:Amphotericin B