Pulsed ultrasound enhances the killing of Escherichia coli biofilms by aminoglycoside antibiotics in vivo.
Escherichia coli biofilms on two polyethylene disks were implanted subcutaneously into rabbits receiving systemic gentamicin. Ultrasound was applied for 24 h to one disk. Both disks were removed, and viable bacteria were counted. Pulsed ultrasound significantly reduced bacterial viability below that of nontreated biofilms without damage to the skin.
Rediske
A M
AM
Department of Microbiology, Brigham Young University, Provo, Utah.
Roeder
B L
BL
Nelson
J L
JL
Robison
R L
RL
Schaalje
G B
GB
Robison
R A
RA
Pitt
W G
WG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development; D004927:Escherichia coli Infections / Q000382:microbiology; D005839:Gentamicins / Q000494:pharmacology*; D016459:Prosthesis-Related Infections / Q000382:microbiology; D011817:Rabbits; D014465:Ultrasonics
D000900:Anti-Bacterial Agents; D005839:Gentamicins