Activation of apoptosis and its inhibition.
The induction of apoptosis, or controlled cell death, by various stimuli has been shown to activate a cascade of endoproteases, called caspases, that cleave numerous cellular proteins necessary for cellular homeostasis. This review discusses this family of proteases together with a variety of mammalian and viral regulatory proteins that act to control this activation.
Miller
D K
DK
Department of Immunology and Rheumatology, Merck Research Laboratories, Rahway, New Jersey 07065, USA. douglas_miller@merck.com
D000818:Animals; D017209:Apoptosis; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D004789:Enzyme Activation; D013379:Substrate Specificity
D061945:Caspase Inhibitors; D015853:Cysteine Proteinase Inhibitors; D020169:Caspases