title: Scanning tunnelling microscopy and molecular modelling of xanthine monolayers self-assembled at the solid-liquid interface: relevance to the origin of life.
abstract: The development of scanning tunnelling microscopy (STM) has allowed examination of inorganic crystalline surfaces and their interactions with organic adsorbates with unparalleled resolution. As a novel technique in origin of life studies, the application of STM is detailed with particular attention paid to the methods employed in the analysis of organic monolayer structures. STM imaging and molecular modelling of self-assembled monolayers of the purine base, xanthine, formed on the surfaces of graphite and molybdenum disulfide are presented as an example. The putative role of such structures in the origin of life is discussed.
authors.affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand.
authors.forename: S J
authors.initials: SJ
authors.lastname: Sowerby
authors.forename: G B
authors.initials: GB
authors.lastname: Petersen
mesh_terms: D006860:Hydrogen Bonding; D017348:Microscopy, Electron, Scanning Transmission; D008956:Models, Chemical; D008958:Models, Molecular; D008968:Molecular Conformation; D000069497:Origin of Life; D019820:Xanthine / Q000737:chemistry*
chemical_list: D019820:Xanthine