title: Endometrial cancer in Olmsted County, MN: trends in incidence, risk factors and survival.
abstract: OBJECTIVE
  We updated an earlier study in this community from 1945-1974 in order to assess trends in the incidence of, risk factors for, and survival from endometrial cancer in 1975-1991.
  
  
  METHODS
  Incidence rates were based on all new cases of endometrial cancer diagnosed among Olmsted County, Minnesota, women during the years 1975-1991, with the population denominator from decennial census data. Risk factors were assessed with conditional logistic regression comparing the incidence cases to age- and gender-matched controls with intact uteri seen the same year the case was diagnosed. Survival was assessed using the Kaplan-Meier method.
  
  
  RESULTS
  The incidence of endometrial cancer (age-adjusted to 1970 United States total) in 1975-1991 was 14.3 per 100,000 person-years, which is slightly increased from 1965-74. The rate was 21.7 per 100,000 person-years after adjustment for hysterectomy prevalence. As in the previous study, conjugated estrogen use for six months or more (odds ratio [OR] 2.71; 95% confidence interval [CI] 1.14-6.46) and body mass index (OR 1.06; 95% CI 1.01-1.11) increased the risk of endometrial cancer. The five-year relative survival rate (82%) was not improved over the earlier study.
  
  
  CONCLUSIONS
  A small increase in endometrial cancer incidence was linked to the same risk factors identified in an earlier study in this community. No improvement in survival was seen.
authors.affiliation: Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Beard
authors.forename: L C
authors.initials: LC
authors.lastname: Hartmann
authors.forename: G L
authors.initials: GL
authors.lastname: Keeney
authors.forename: C S
authors.initials: CS
authors.lastname: Crowson
authors.forename: G D
authors.initials: GD
authors.lastname: Malkasian
authors.forename: P C
authors.initials: PC
authors.lastname: O'Brien
authors.forename: L J
authors.initials: LJ
authors.lastname: Melton
mesh_terms: D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000401:mortality; D015914:Estrogen Replacement Therapy / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000706:statistics & numerical data; D015994:Incidence; D016015:Logistic Models; D008910:Minnesota / Q000453:epidemiology; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors