title: Regulation of cutaneous allergic reaction by odorant inhalation.
abstract: Olfactory stimuli modulate emotional conditions and the whole body immune system. Effects of odorant inhalation on cutaneous immune reaction were examined. Contact hypersensitivity to 2,4, 6-trinitrochlorobenzene was elicited in C57BL/6 mice. The reaction was suppressed at both the induction and elicitation phases by exposure to an odorant, citralva. Topical application of citralva or lyral/lilial did not affect the reaction. The suppressive effect of citralva was more potent than that of another odorant, lyral/lilial. Citralva decreased the number of epidermal Langerhans cells, whereas lyral/lilial had a weak effect. Citralva but not lyral/lilial induced plasma corticosterone. Glucocorticoid receptor antagonist abrogated the suppressive effect of citralva on contact hypersensitivity. Serum interleukin-12 was downregulated by exposure to citralva or lyral/lilial. These data demonstrate that olfactory stimuli regulate the cutaneous immune system.
authors.affiliation: Life Science Research Center, Shiseido, Yokohama, Japan. junichi.hosoi@to.shiseido.co.jp
authors.forename: J
authors.initials: J
authors.lastname: Hosoi
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000447:Aldehydes / Q000494:pharmacology; D000485:Allergens; D000818:Animals; D053138:Cyclohexenes; D016207:Cytokines / Q000097:blood; D003877:Dermatitis, Contact / Q000517:prevention & control*; D005260:Female; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D007801:Langerhans Cells / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009570:Nitriles / Q000494:pharmacology*; D009812:Odorants; D010476:Perfume; D018035:Receptors, Odorant / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000485:Allergens; D053138:Cyclohexenes; D016207:Cytokines; D009570:Nitriles; D010476:Perfume; D018035:Receptors, Odorant; D016753:Interleukin-10; D018664:Interleukin-12; C054764:citralva; C092244:hydroxyisohexyl 3-cyclohexene carboxaldehyde