cDNA cloning of run, a Caenorhabditis elegans Runt domain encoding gene.
PEBP2/CBF is a heterodimeric transcription factor composed of alpha and beta subunits. The essential roles of mammalian PEBP2alpha genes, PEBP2aA/CBFA1 and PEBP2alphaB/CBFA2 in osteogenesis and hematopoiesis have been well documented. The PEBP2alpha proteins contain a 128 amino acid (aa) region which is highly homologous to Drosophila melanogaster runt and lozenge. The evolutionarily conserved region has been named the Runt domain. In this study, we isolated a cDNA encoding the Caenorhabditis elegans homolog of mammalian PEBP2alpha. The cDNA encodes a 301-aa protein with a highly conserved Runt domain. In addition, a IWRPF five aa motif is present at the C-terminal end.
Bae
S C
SC
Department of Biochemistry, School of Medicine, Chungbuk National University, Chungju, South Korea. scbae@med.chungbuk.ac.kr
Lee
J
J
D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D017238:Genes, Helminth; D016678:Genome; D015801:Helminth Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D015801:Helminth Proteins