[The effect of divalent cations on pepsinogen extrusion by permeable isolated gastric glands].
The model of permeable gastric glands obtained by its incubation with digiton (15 mg/ml) had investigated. It was shown, that stimulated influence of Ca2+ ions on pepsinogen extrusion completely or partly reproduced by cations of transient metals. Stimulated effects of cations of metals (5 x 10(-4) M) decrease in such order: Ca2+ > Cd2+ > Mn2+ > Co2+ > La3+. Nevertheless, Co2+ and La3+ in the same concentrations inhibit Ca2+ stimulated extrusion of pepsinogen by permeable isolated glands. Stimulated effect of Cd2+ and La3+ on pepsinogen extrusion in native glands was not reproducible. Besides these cations inhibit carbacholine-stimulated extrusion in native glands. It's concluded, that influence of metal cations on secretory function of gastric glands to a great extent is determined by their property to penetrate into secretory cells and cooperate with their plasma membranes.
Dubyts'kyĭ
L O
LO
I. Franko University, Ministry of Education of Ukraine, Lviv.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D002413:Cations, Divalent; D002463:Cell Membrane Permeability / Q000187:drug effects; D004072:Digitonin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007811:Lanthanum / Q000493:pharmacokinetics / Q000494:pharmacology*; D019216:Metals, Heavy / Q000493:pharmacokinetics / Q000494:pharmacology*; D020116:Pepsinogen A / Q000187:drug effects* / Q000378:metabolism; D013268:Stimulation, Chemical
D002413:Cations, Divalent; D019216:Metals, Heavy; D007811:Lanthanum; D002217:Carbachol; D020116:Pepsinogen A; D004072:Digitonin