title: Efficacy and effectiveness of five day treatment of uncomplicated falciparum with artemisinin or artesunate in Vietnam.
abstract: A study on efficacy and effectiveness of artemisinin (total dose of 60 mg/kg) and artesunate (total dose of 12 mg/kg over five days) in treatment of uncomplicated malaria was conducted in highly malaria transmitted areas in Vietnam. 126 uncomplicated malaria cases finished 14 day follow-up. 100% cure rate achieved at day 14 in patients of the efficacy groups received either artemisinin or artesunate, while it was 83% and 93% in patients treated respectively with artemisinin and artesunate of the effectiveness groups. Compliance of the treatment regimens was discussed.
authors.affiliation: Institute of Malariology, Parasitology and Entomology, Ha Noi, Vietnam.
authors.forename: N B
authors.initials: NB
authors.lastname: Le
authors.forename: T Y
authors.initials: TY
authors.lastname: Pham
authors.forename: B N
authors.initials: BN
authors.lastname: Nguyen
authors.forename: C T
authors.initials: CT
authors.lastname: Dang
authors.forename: T L
authors.initials: TL
authors.lastname: Pham
authors.forename: D C
authors.initials: DC
authors.lastname: Le
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D037621:Artemisinins; D000077332:Artesunate; D002648:Child; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D005334:Fever / Q000469:parasitology; D005500:Follow-Up Studies; D006801:Humans; D007783:Lactones / Q000494:pharmacology / Q000627:therapeutic use*; D016778:Malaria, Falciparum / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D012717:Sesquiterpenes / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome; D014744:Vietnam
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D007783:Lactones; D012717:Sesquiterpenes; D000077332:Artesunate; C075875:artemisin