title: Oral acyclovir for the management of herpes simplex virus keratitis in children.
abstract: OBJECTIVE
  To evaluate the use of oral acyclovir in pediatric patients with herpes simplex virus (HSV) keratitis.
  
  
  METHODS
  Retrospective noncomparative case series.
  
  
  METHODS
  Seven pediatric patients seen at the University of Minnesota Hospitals and Clinics with herpes simplex virus (HSV) infectious epithelial keratitis between January 1992 and October 1998. Patient ages ranged from 6 weeks to 5 years at time of presentation with a median of 1.7 and mean of 1.9 years.
  
  
  METHODS
  All patients received oral acyclovir; six of seven patients also received topical antiviral medications. Three of seven patients had topical antiviral therapy fail before being placed on oral acyclovir, and the remaining four patients were placed on oral acyclovir primarily.
  
  
  RESULTS
  All patients showed resolution of HSV infectious epithelial keratitis. Three patients have been maintained on prophylactic dosage of oral acyclovir because of recurrent disease or because they have been chronically treated with topical corticosteroids for immune stromal keratitis. All patients tolerated acyclovir well, and there were no adverse reactions.
  
  
  CONCLUSIONS
  Oral acyclovir is useful in treating HSV infectious epithelial keratitis in pediatric patients. It is beneficial in treating infectious epithelial keratitis and prophylactically either while treating with topical corticosteroids for immune stromal keratitis or for preventing recurrent infectious epithelial keratitis.
authors.affiliation: University of Minnesota, Department of Ophthalmology, Minneapolis, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Schwartz
authors.forename: E J
authors.initials: EJ
authors.lastname: Holland
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000284:Administration, Oral; D000998:Antiviral Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D003315:Cornea / Q000187:drug effects / Q000821:virology; D005260:Female; D018259:Herpesvirus 1, Human / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D016849:Keratitis, Herpetic / Q000188:drug therapy* / Q000821:virology; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir