[Expression of CD44V6 and nm23-H1 in thyroid papillary adenocarcinoma and lymph node metastasis].
Expression of CD44V6 and nm23-H1 in thyroid papillary adenocarcinoma (TPC) was studied in 84 patients by immunohistochemistry. The positive rates of CD44V6 and nm23-H1 were 63.1% and 48.8% respectively. An increased CD44V6 and a decreased nm23-H1 positive rate in patients with lymph node metastasis (LNM) were observed (P < 0.01). Negative correlation was existed between overexpression of CD44V6 and low-expression of nm23-H1 (P < 0.01). The results suggested that CD44V6 and nm23-H1 play important role in LNM of TPC and disordered expression of CD44V6 and nm23-H1 are involved in the process of LNM.
Wei
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Q
Department of Pathology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Fan
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D000231:Adenocarcinoma, Papillary / Q000378:metabolism* / Q000556:secondary; D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000096:biosynthesis*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis*; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology; D014157:Transcription Factors / Q000096:biosynthesis*
D000951:Antigens, Neoplasm; C112697:CD44v6 antigen; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins