[Clinical case of the month. Mental confusion due to the administration of tramadol in a patient treated with MOAI].
However currently less used, MAOI (monoamine-oxidase inhibitor) antidepressants have specific indications like refractory or atypical depressions. The main difficulties related to MAOI therapy consist in their potentially very dangerous interactions with certain foods on the one side, many medications on the other side. For example, we report the case of a patient treated for a resistant depression by phenelzine (Nardelzine) who presented a severe delirium after the administration of tramadol (Contramal, Dolzam). This case shows the importance of particular attention before the association of any drug in a patient treated by MAOI.
Calvisi
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Service de Psychiatrie et Psychologie médicale, Université de Liège.
Ansseau
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M
D003221:Confusion / Q000139:chemically induced*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology*; D009294:Narcotics / Q000009:adverse effects* / Q000493:pharmacokinetics; D010624:Phenelzine / Q000493:pharmacokinetics / Q000494:pharmacology*; D014147:Tramadol / Q000009:adverse effects* / Q000493:pharmacokinetics
D008996:Monoamine Oxidase Inhibitors; D009294:Narcotics; D014147:Tramadol; D010624:Phenelzine