In vivo lymphoproliferation in the popliteal lymph node (PLN) assay can be inhibited by leflunomide's active metabolite A77 1726.
Schorlemmer
H U
HU
Research Laboratories, Hoechst Marion Roussel Deutschland GmbH, DG Rheumatology, Frankfurt, Germany. hansulrich.schorlemmer@hmrag.com
Kurrle
R
R
Schleyerbach
R
R
Bartlett
R R
RR
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D003437:Crotonates; D004305:Dose-Response Relationship, Drug; D006087:Graft vs Host Reaction / Q000187:drug effects; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007555:Isoxazoles / Q000378:metabolism / Q000494:pharmacology; D000077339:Leflunomide; D008198:Lymph Nodes / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D009570:Nitriles; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D014052:Toluidines
D000814:Aniline Compounds; D003437:Crotonates; D006885:Hydroxybutyrates; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D009570:Nitriles; D014052:Toluidines; C527525:teriflunomide; D000077339:Leflunomide