Determination of zinc contents in rabbits with cerebral ischemia by NAA and ICP-AES.
Cerebral ischemia is an important cerebral vascular disease, and zinc is a necessary trace element for humans. In this work, a cerebral ischemia model of rabbit was established by operation. The samples of brain and serum in the animal models were collected. The Zn contents in the samples were determined by neutron activation analysis and inductively coupled plasma-atomic emission spectrometry. The results show the Zn contents in brain decreased 2 mo after cerebral ischemia, and Zn contents in serum decreased even more obviously. In addition, a positive correlation of Zn contents between left and right cerebral hemispheres was observed, and the positive correlation between brain and serum was also observed. A test of Chinese medicine was also carried out in the work. Two Chinese medicines were fed to rabbits with cerebral ischemia in the experiments. The results showed they probably can prevent the decrease of Zn contents in serum.
Wang
Y
Y
Shanghai Institute of Nuclear Research, Academia Sinica.
Zhao
H
H
Zhang
T
T
Tan
M
M
Zhuang
G
G
Chen
B
B
Huang
Z
Z
Tian
H
H
Sun
Q
Q
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000097:blood / Q000378:metabolism*; D004365:Drugs, Chinese Herbal; D013058:Mass Spectrometry / Q000379:methods; D009501:Neutron Activation Analysis; D011817:Rabbits; D015032:Zinc / Q000032:analysis* / Q000097:blood
D004365:Drugs, Chinese Herbal; D015032:Zinc