D1 dopamine receptor signalling defect in spontaneous hypertension.
Dopamine modulates cardiovascular function by actions in the central and peripheral nervous system, by altering the secretion/release of prolactin, pro-opiomelanocortin, vasopressin, aldosterone, and renin, and by directly affecting renal function. Dopamine produced by the renal proximal tubule exerts an autocrine/paracrine action via two classes of dopamine receptors, D1-like (D1 and D5) and D2-like (D2, D3, and D4), that are differentially expressed along the nephron. The autocrine/paracrine function of dopamine, manifested by tubular rather than by haemodynamic mechanisms, becomes most evident during extracellular fluid volume expansion. This renal autocrine/paracrine function is lost in essential hypertension and in some animal models of genetic hypertension. The molecular basis for the dopaminergic dysfunction in hypertension may involve an abnormal post-translational modification of dopamine receptors.
Felder
R A
RA
Department of Pathology, University of Virginia Center for the Health Sciences, Charlottesville, VA, USA.
Eisner
G M
GM
Jose
P A
PA
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000235:genetics / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000502:physiology; D011954:Receptors, Dopamine / Q000502:physiology; D017447:Receptors, Dopamine D1 / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D011956:Receptors, Cell Surface; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D019204:GTP-Binding Proteins