title: Airflow obstruction in bronchiectasis: correlation between computed tomography features and pulmonary function tests.
abstract: BACKGROUND
  An obstructive defect is usual in bronchiectasis, but the pathophysiological basis of airflow obstruction remains uncertain. High resolution computed tomographic (CT) scanning now allows quantitation of static morphological abnormalities, as well as dynamic changes shown on expiratory CT scans. The aim of this study was to determine which static and dynamic structural abnormalities on the CT scan are associated with airflow obstruction in bronchiectasis.
  
  
  METHODS
  The inspiratory and expiratory features on the CT scan of 100 patients with bronchiectasis undergoing concurrent lung function tests were scored semi-quantitatively by three observers.
  
  
  RESULTS
  On univariate analysis the extent and severity of bronchiectasis, the severity of bronchial wall thickening, and the extent of decreased attenuation on the expiratory CT scan correlated strongly with the severity of airflow obstruction; the closest relationship was seen between decreased forced expiratory volume in one second (FEV(1)) and the extent of decreased attenuation on the expiratory CT scan (R(s) = -0.55, p<0. 00005). On multivariate analysis bronchial wall thickness and decreased attenuation were consistently the strongest independent determinants of airflow obstruction. The extent of decreased attenuation was positively associated with the severity of bronchial wall thickness, but was not independently linked to gas transfer levels. Endobronchial secretions seen on CT scanning had no functional significance; the severity of bronchial dilatation was negatively associated with airflow obstruction after adjustment for other morphological features.
  
  
  CONCLUSIONS
  These findings indicate that airflow obstruction in bronchiectasis is primarily linked to evidence of intrinsic disease of small and medium airways on CT scanning and not to bronchiectatic abnormalities in large airways, emphysema, or retained endobronchial secretions.
authors.affiliation: Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Roberts
authors.forename: A U
authors.initials: AU
authors.lastname: Wells
authors.forename: D G
authors.initials: DG
authors.lastname: Milne
authors.forename: M B
authors.initials: MB
authors.lastname: Rubens
authors.forename: J
authors.initials: J
authors.lastname: Kolbe
authors.forename: P J
authors.initials: PJ
authors.lastname: Cole
authors.forename: D M
authors.initials: DM
authors.lastname: Hansell
mesh_terms: D000328:Adult; D000368:Aged; D001987:Bronchiectasis / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D001988:Bronchiolitis / Q000175:diagnosis; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012115:Residual Volume; D014057:Tomography, X-Ray Computed; D014109:Total Lung Capacity; D014797:Vital Capacity / Q000502:physiology