title: Role of Fas--FasL interactions in the pathogenesis and regulation of autoimmune demyelinating disease.
abstract: Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) represent complex processes that lead to destruction of oligodendrocytes (ODCs) and myelin. T cells are integral to the development of these diseases, but whether T cell-mediated cytolytic mechanisms are involved in the destruction of MHC Class II-negative targets, such as oligodendroglia and myelin, in the CNS is unclear. The primary lytic mechanism employed by CD4+ T cells is Fas-dependent, but can be MHC-unrestricted. Thus, T cell-mediated Fas-FasL interactions could directly contribute to the pathology of EAE and MS. This review summarizes studies from our laboratory and others that implicate Fas-FasL interactions in both the pathogenesis and regulation of demyelinating diseases.
authors.affiliation: Department of Molecular Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Sabelko-Downes
authors.forename: J H
authors.initials: JH
authors.lastname: Russell
authors.forename: A H
authors.initials: AH
authors.lastname: Cross
mesh_terms: D000818:Animals; D016923:Cell Death / Q000276:immunology; D020278:Demyelinating Autoimmune Diseases, CNS / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D019463:Mice, Inbred MRL lpr; D008822:Mice, Transgenic; D018448:Models, Immunological; D009103:Multiple Sclerosis / Q000276:immunology; D009186:Myelin Sheath / Q000276:immunology; D009836:Oligodendroglia / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D019014:fas Receptor / Q000378:metabolism*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D019014:fas Receptor