title: Role of the IGF system in trophoblast invasion and pre-eclampsia.
abstract: Insulin-like growth factor-II (IGF-II) and IGF binding protein-1 (IGFBP-1) appear to play an important role in paracrine interactions at the maternal-fetal interface in human pregnancy. Patterns of expression of IGF-II and IGFBP-1 at the decidual-trophoblast interface suggest paracrine interactions occur between the IGF-II-expressing invading cytotrophoblast and maternal decidua-derived IGFBP-1. Autocrine/paracrine actions of trophoblast-derived IGF-II may be important in invasion, and for both trophoblast and decidual function. The actions of IGFBP-1 in binding IGF, and as an integrin ligand, suggest it may have multiple roles in the interactions between the invading trophoblast and the maternal decidua. Abundant decidual IGFBP-1 may interact with the IGF-II-expressing, protease-secreting trophoblast to modulate invasion. In-vitro studies of trophoblast-decidual cell interactions in invasion, and clinical observations in a gestational disorder with shallow placental invasion such as pre-eclampsia, have provided new insights into the possible role(s) of IGFBP-1 in trophoblast invasion. The precise mechanisms underlying IGF and IGFBP-1 action at the decidual-trophoblast interface remain to be elucidated. The potential predictive value of serum IGFBP-1 concentrations in pre-eclampsia also remains to be established.
authors.affiliation: Department of Gynecology & Obstetrics, Stanford University Medical Center, CA 94305-5317, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Irwin
authors.forename: L F
authors.initials: LF
authors.lastname: Suen
authors.forename: N A
authors.initials: NA
authors.lastname: Martina
authors.forename: S P
authors.initials: SP
authors.lastname: Mark
authors.forename: L C
authors.initials: LC
authors.lastname: Giudice
mesh_terms: D003656:Decidua / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology*; D005260:Female; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000502:physiology; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy; D013002:Somatomedins / Q000502:physiology*; D014327:Trophoblasts / Q000502:physiology*
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D013002:Somatomedins