title: Effects of metoprolol and ramipril on action potentials after myocardial infarction in rats.
abstract: The effects of chronic treatment with the beta-adrenoceptor antagonist metoprolol, the angiotensin converting enzyme inhibitor ramipril, their combination, or placebo on action potential configuration 6 weeks after myocardial infarction in rats were studied. Action potentials were measured in isolated left ventricular posterior papillary muscles and compared with action potentials from a sham operated group without infarction. After infarction, the action potential amplitude was reduced and this phenomenon was partially reversed by metoprolol- and ramipril-treatment. Prolonged repolarisation after infarction compared to sham operated animals was additionally delayed after metoprolol treatment. Thus, metoprolol extends the refractory period, which may counteract tachyarrhythmia.
authors.affiliation: Institute of Physiology, Humboldt University (Charité),Tucholskystr. 2 10117, Berlin, Germany. kay-dietrich.wagner@charite.de
authors.forename: K
authors.initials: K
authors.lastname: Wagner
authors.forename: A
authors.initials: A
authors.lastname: Kamkin
authors.forename: I
authors.initials: I
authors.lastname: Kiseleva
authors.forename: H
authors.initials: H
authors.lastname: Theres
authors.forename: H
authors.initials: H
authors.lastname: Scholz
authors.forename: J
authors.initials: J
authors.lastname: Günther
mesh_terms: D000200:Action Potentials; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D004558:Electric Stimulation; D006321:Heart / Q000503:physiopathology*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000503:physiopathology*; D017257:Ramipril / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D008790:Metoprolol; D017257:Ramipril