Involvement of carbon monoxide in the innervation of the canine cervical esophagus and trachea.
We investigated the involvement of carbon monoxide (CO) in the innervation of the canine cervical esophagus and trachea by means of immunohistochemistry using an antiserum against heme oxygenase-2 (HO-2). We detected HO-2-immunoreactive nerve fibers around the blood vessels and submucosal glands of the esophagus and trachea. We found HO-2-immunoreactive neurons in ganglia in the trachea and in the myenteric plexus of the esophagus. These results suggest that CO is involved as a neurotransmitter in the innervation of the canine esophagus and trachea.
Hisa
Y
Y
Department of Otolaryngology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Japan.
Koike
S
S
Bamba
H
H
Shogaki
K
K
Tadaki
N
N
Uno
T
T
D000818:Animals; D002248:Carbon Monoxide / Q000502:physiology*; D004285:Dogs; D004947:Esophagus / Q000294:innervation*; D006419:Heme Oxygenase (Decyclizing) / Q000032:analysis; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000737:chemistry; D018377:Neurotransmitter Agents / Q000502:physiology*; D014132:Trachea / Q000294:innervation*
D018377:Neurotransmitter Agents; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)