Interactions of galanin and morphine in the spinal antinociception in rats with mononeuropathy.
The increased hind-paw withdrawal latency (HWL) to thermal stimulation and hind-paw withdrawal threshold (HWT) to mechanical stimulation induced by morphine were attenuated by intrathecal injection of 1 or 3 nmol, but not 0.3 nmol of the selective galanin antagonist galantide. The result indicated a possible interaction between galanin and opioids in the transmission of presumed nociceptive information in the spinal cord of rats with mononeuropathy.
Zhang
Y P
YP
Department of Physiology and National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Science, Peking University, Beijing, China.
Lundeberg
T
T
Yu
L C
LC
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D003714:Denervation; D004347:Drug Interactions; D019004:Galanin / Q000494:pharmacology*; D006358:Hot Temperature; D007278:Injections, Spinal; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D012584:Sciatic Nerve / Q000502:physiology / Q000601:surgery; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D000701:Analgesics, Opioid; D009020:Morphine; D019004:Galanin