[Correlations of T lymphocyte subsets and IL-2, sIL-2R in patients with malignant ovarian tumor].
To study the relation between malignant ovarian tumor (MOT) and cell mediated immunity, the numbers of T lymphocyte subsets and levels of IL-2 and sIL-2R were measured simultaneously in 40 patients with MOT and 30 normal controls (NC), and the correlations between T subsets and IL-2, T subsets and sIL-2R were analyzed. The results were as follows: (1) The numbers of CD3+, CD4+, CD4+/CD8+ and the levels of IL-2 in the patients were lower than those in the NC significantly, and the opposite results were observed about CD8+ and sIL-2R (P < 0.01-0.001); (2) There were positive correlations between CD3+, CD4+, CD4+/CD8+ and IL-2 and there were negative correlations between CD3+, CD4+, CD4+/CD8+ and sIL-2R in MOT group (P < 0.01-0.001). The results suggested that the T lymphocyte immune function in MOT group was decreased. The reduced numbers of CD3+, CD4+, CD4+/CD8+ were related to the decreased levels of IL-2 and the increased levels of sIL-2R. It may be an important factor of incidence and development in MOT.
Wang
H
H
Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chengdu.
Peng
Z
Z
Zhang
C
C
D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000097:blood*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2