[The influence of L-triiodothyronine on the action of desipramine on beta and serotonin 2A receptor, monoamines in the rat brain].
The co-administration of thyroid hormone and antidepressants is often useful in the treatment of refractory depression. The aim of this study is to clarify the anti-depressive mechanisms of repeated co- administration of thyroid hormone (T3) and desipramine (DMI) in the rat brain. Forced swimming test, open-field test, monoamine contents, beta receptor, and serotonin (5HT)2A receptor were compared in four experimental groups (control, T3, DMI, DMI+T3). In the forced swimming test, the (DMI+T3) group showed a significantly decreased immobility time compared with that of the control group. The noradrenaline (NA) content in the prefrontal cortex was highest in the (DMI+T3) group. Although beta receptor was not altered in any brain region in the (DMI+T3) group, 5HT2A receptor was significantly decreased, and the dopamine (DA) turnover rate was significantly increased in the prefrontal cortex. This study suggests that the addition of T3 enhanced the action of DMI alone on the monoaminergic system in the prefrontal cortex.
Watanabe
A
A
Department of Neuropsychiatry, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Japan.
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage*; D015306:Biogenic Monoamines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D003891:Desipramine / Q000008:administration & dosage*; D004298:Dopamine / Q000032:analysis; D004357:Drug Synergism; D008297:Male; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A; D011943:Receptors, Adrenergic, beta / Q000032:analysis*; D011985:Receptors, Serotonin / Q000032:analysis*; D014284:Triiodothyronine / Q000008:administration & dosage*
D000928:Antidepressive Agents; D015306:Biogenic Monoamines; D044402:Receptor, Serotonin, 5-HT2A; D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin; D014284:Triiodothyronine; D003891:Desipramine; D004298:Dopamine; D009638:Norepinephrine