Antinociceptive substances from Incarvillea delavayi.
Antinociceptive activities of an Incarvillea delavayi extract, as well as its constituents, 8-epideoxyloganic acid and delavayine A, were evaluated in the acetic acid induced writhing test in mice. An oral administration of the delavayi extract weakly decreased the number of writhings and stretchings in this test, in a dose-dependent manner. Furthermore, orally administered 8-epideoxyloganic acid showed weak antinociceptive activity, whereas administration by subcutaneous injection did not. However, subcutaneous injection of delavayine A, a novel monoterpene alkaloid, showed a more significant level of antinociceptive activity.
Nakamura
M
M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Kido
K
K
Kinjo
J
J
Nohara
T
T
D000284:Administration, Oral; D000470:Alkaloids; D000700:Analgesics / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D039821:Monoterpenes; D010146:Pain / Q000188:drug therapy; D010147:Pain Measurement; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013729:Terpenes / Q000737:chemistry* / Q000302:isolation & purification
C404985:8-epideoxyloganic acid; D000470:Alkaloids; D000700:Analgesics; D039821:Monoterpenes; D010936:Plant Extracts; D011714:Pyrans; D013729:Terpenes; C404986:delavayine A