title: Combined electroconvulsive-clozapine therapy.
abstract: We reviewed 36 reported psychiatric patients who were treated with a combination of electroconvulsive therapy (ECT) and clozapine. The indication of the ECT-clozapine treatment was resistance to classical antipsychotic agents, clozapine, or ECT alone. Sixty-seven percent of the patients benefited from the combined treatment. In most of the patients, the combined treatment was safe and well tolerated. Adverse reactions occurred in 16.6% of the patients and included prolonged ECT-induced seizures (one case), supraventricular (one case) and sinus tachycardia, and blood pressure elevation. It seems that combined ECT-clozapine treatment is effective and safe. This strategy may be a therapeutic option in treatment-resistant patients.
authors.affiliation: Ness Ziona Mental Health Center, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Kupchik
authors.forename: B
authors.initials: B
authors.lastname: Spivak
authors.forename: R
authors.initials: R
authors.lastname: Mester
authors.forename: I
authors.initials: I
authors.lastname: Reznik
authors.forename: N
authors.initials: N
authors.lastname: Gonen
authors.forename: A
authors.initials: A
authors.lastname: Weizman
authors.forename: M
authors.initials: M
authors.lastname: Kotler
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy / Q000628:therapy; D003024:Clozapine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000188:drug therapy / Q000628:therapy; D004565:Electroconvulsive Therapy; D005260:Female; D006801:Humans; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy / Q000628:therapy*; D012559:Schizophrenia / Q000188:drug therapy / Q000628:therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine