title: Frequencies of HLA-A2 alleles in five U.S. population groups. Predominance Of A*02011 and identification of HLA-A*0231.
abstract: Direct DNA sequencing was used to determine the frequency of alleles within the HLA-A2 family in five US population groups. The most frequently detected HLA-A2 allele in all groups was HLA-A*02011. Caucasian and Native American populations appear to be the most homogeneous exhibiting 95.7% and 94.3% A*02011, respectively. Hispanic and Asian/Pacific Islander populations were the most allelicly diverse populations with 9 and 7 different HLA-A2 alleles present, respectively, but the majority of the populations were HLA-A*02011. African-Americans were also diverse, not in the number of alleles seen, but in the percentage of non-A*02011 alleles in the population. HLA-A*0202 (25.8%) and A*0205 (12.9%) were present in a large percentage of African-Americans. Only 13 of the 31 known HLA-A2 alleles were observed in the study. The allelic distributions reflected statistically significant differences among population groups.
authors.affiliation: Department of Microbiology, Georgetown University Medical Center, Washington, DC, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Ellis
authors.forename: V
authors.initials: V
authors.lastname: Henson
authors.forename: R
authors.initials: R
authors.lastname: Slack
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: R J
authors.initials: RJ
authors.lastname: Hartzman
authors.forename: C
authors.initials: C
authors.lastname: Katovich Hurley
mesh_terms: D001741:Black or African American; D000483:Alleles; D000595:Amino Acid Sequence; D001213:Asian; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D015789:HLA-A2 Antigen / Q000235:genetics*; D006630:Hispanic or Latino; D006801:Humans; D007198:Indians, North American; D008969:Molecular Sequence Data; D010641:Phenotype; D014481:United States
chemical_list: D015789:HLA-A2 Antigen