title: CD101 expression by Langerhans cell histiocytosis cells.
abstract: OBJECTIVE
  Our objective was to study the expression of a recently identified cell surface molecule, CD101 and in Langerhans cell histiocytosis (LCH) patients as CD101 has been shown to be present on dendritic cells. We wanted to determine if CD101 expression could be helpful for the diagnosis of LCH in conjunction with other markers (CD1a, S100 protein), and could be predictive of the evolution and dissemination of the disease.
  
  
  RESULTS
  The expression of CD101 was studied by immunohistochemical technique in 11 cases of Langerhans cell histiocytosis on frozen sections. The expression of CD101 was positive in nine cases, high in six cases and low in three cases. There was no expression in the other two cases. No correlation with the evolution, the localization or the dissemination of the disease could be evidenced.
  
  
  CONCLUSIONS
  CD101 is a new phenotypic marker that might be useful in combination with other markers for the diagnosis of LCH. However, as the anti-CD101 antibody works only in frozen sections, its value is limited compared to anti-CD1a antibody.
authors.affiliation: Department of Dermatology; INSERM U448; Department of Pathology, Hôpital Henri-Mondor, Créteil, France. bouloc@univ-paris12.fr
authors.forename: A
authors.initials: A
authors.lastname: Bouloc
authors.forename: M L
authors.initials: ML
authors.lastname: Boulland
authors.forename: F
authors.initials: F
authors.lastname: Geissmann
authors.forename: S
authors.initials: S
authors.lastname: Fraitag
authors.forename: P
authors.initials: P
authors.lastname: Andry
authors.forename: D
authors.initials: D
authors.lastname: Teillac
authors.forename: A
authors.initials: A
authors.lastname: Bensussan
authors.forename: J
authors.initials: J
authors.lastname: Revuz
authors.forename: L
authors.initials: L
authors.lastname: Boumsell
authors.forename: J
authors.initials: J
authors.lastname: Wechsler
authors.forename: M
authors.initials: M
authors.lastname: Bagot
mesh_terms: D017951:Antigen Presentation; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D006646:Histiocytosis, Langerhans-Cell / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C093213:CD101 antigen, human; D008562:Membrane Glycoproteins