Antihyperglycaemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats.
Musa sapientum commonly known as 'banana' is widely used in Indian folk medicine for the treatment of diabetes mellitus. Oral administration of 0.15, 0.20 and 0.25 g/kg body weight of the chloroform extract of the flowers for 30 days resulted in a significant reduction in blood glucose and glycosylated haemoglobin and an increase in total haemoglobin. The extract prevented a decrease in body weight, and also resulted in a decrease in free radical formation in the tissues. Thus the study shows that banana flower extract (BFEt) has an antihyperglycaemic action. The decrease in thiobarbituric acid reactive substances (TBARS) and the increase in reduced glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) clearly shows the antioxidant property of BFEt. The effect of BFEt was more prominently seen in the case of animals given 0.25 g/kg body weight. BFEt was more effective than glibenclamide.
Pari
L
L
Department of Biochemistry, Annamalai University, Annamalai Nagar - 608 002, Tamil Nadu, India.
Umamaheswari
J
J
D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects*; D002374:Catalase / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D005978:Glutathione / Q000187:drug effects / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000187:drug effects / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D019862:Zingiberales / Q000627:therapeutic use*
D001786:Blood Glucose; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D000496:Alloxan; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione