title: [Antiepileptic effects of nimodipine on penicillin-induced seizures in rats].
abstract: Injecting penicillin (PNC) intraperitoneally in Wistar rats, we observed their epileptic behaviour and electroencephalographys. The results showed that nimodipine (NIM), a calcium antagonist, could inhibit the seizures and epileptic discharges significantly. No epileptic action was noted while NIM was injected before PNC. It supports our consideration of NIM as a new sort of nonsedative anticonvulsant in clinical practice.
authors.affiliation: Department of Neurology, First Affiliated Hospital, Chengdu.
authors.forename: X
authors.initials: X
authors.lastname: Zou
authors.forename: X
authors.initials: X
authors.lastname: Ruan
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: Q
authors.initials: Q
authors.lastname: Cai
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D004827:Epilepsy / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D008297:Male; D009553:Nimodipine / Q000627:therapeutic use*; D010406:Penicillins; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000927:Anticonvulsants; D002121:Calcium Channel Blockers; D010406:Penicillins; D009553:Nimodipine