Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity.
8 Semi-synthetic derivatives of asiatic acid were prepared and their protective effect against A beta-induced neurotoxicity was evaluated. Among them, asiatic acid (2), and 4, 16 showed 97, 92 and 87% of protective effect, respectively.
Jew
S S
SS
College of Pharmacy, Seoul National University, South Korea.
Yoo
C H
CH
Lim
D Y
DY
Kim
H
H
Mook-Jung
I
I
Jung
M W
MW
Choi
H
H
Jung
Y H
YH
Kim
H
H
Park
H G
HG
D000544:Alzheimer Disease / Q000188:drug therapy; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D053978:Pentacyclic Triterpenes; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D016229:Amyloid beta-Peptides; D018696:Neuroprotective Agents; D053978:Pentacyclic Triterpenes; D010446:Peptide Fragments; D014315:Triterpenes; C074636:amyloid beta-protein (25-35); C017032:asiatic acid