title: Protective effect of ellagic acid on t-butyl hydroperoxide induced lipid peroxidation in isolated rat hepatocytes.
abstract: Ellagic acid, a plant polyphenol, showed protective effect on isolated rat hepatocytes against destruction due to lipid peroxide formation induced by t-butyl hydroperoxide in vitro. Ellagic acid inhibited the generation of superoxide anions and hydroxyl radicals both in enzymic and non enzymic systems, thus providing protection against oxidative damage.
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: K
authors.initials: K
authors.lastname: Singh
authors.forename: A K
authors.initials: AK
authors.lastname: Khanna
authors.forename: P K
authors.initials: PK
authors.lastname: Visen
authors.forename: R
authors.initials: R
authors.lastname: Chander
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004610:Ellagic Acid / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D020122:tert-Butylhydroperoxide / Q000037:antagonists & inhibitors* / Q000494:pharmacology
chemical_list: D004610:Ellagic Acid; D020122:tert-Butylhydroperoxide