[Materno-fetal platelet allo-immunization revealed by in utero intracerebral fetal hemorrhage: proposed management for the next pregnancy].
Materno-fetal platelet allo-immunization causes fetal or neonatal thrombocytopenia and sometimes severe intracerebral bleeding. The HPA-1s antigen is most generally implicated. This accident can occur during the first pregnancy with a major risk of severe recurrence during the next pregnancy. These women require specific care in a specialized center although no consensus has been reached on management of second pregnancies. Proposed treatments include immunoglobulins and/or corticosteroids, fetal blood puncture and unique or iterative platelet transfusions.
Vauthier-Brouzes
D
D
Service de Gynécologie Obstétrique, CHU Pitié Salpêtrière, 75013 Paris.
Lefebvre
G
G
Saada
P
P
Darbois
Y
Y
Kaplan
C
C
D000032:Abortion, Therapeutic; D016824:Antigens, Human Platelet / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D005260:Female; D005315:Fetal Diseases / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn; D039661:Integrin beta3; D008431:Maternal-Fetal Exchange; D010298:Parity; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012008:Recurrence; D012307:Risk Factors; D013921:Thrombocytopenia / Q000150:complications* / Q000276:immunology*; D016216:Ultrasonography, Prenatal
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D007074:Immunoglobulin G; D039661:Integrin beta3