Reexpression of the major PKC substrate, SSeCKS, correlates with the tumor-suppressive effects of SCH51344 on rat-6/src and rat-6/ras fibroblasts but not on rat-6/raf fibroblasts.
Gelman
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IH
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Xi
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Kumar
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CC
D054758:A Kinase Anchor Proteins; D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D018797:Cell Cycle Proteins; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D011905:Genes, ras; D016391:Genes, src; D008934:Mitogens / Q000235:genetics / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D013379:Substrate Specificity
D054758:A Kinase Anchor Proteins; C102361:Akap12 protein, rat; D000634:Aminoquinolines; D016588:Anticarcinogenic Agents; D018797:Cell Cycle Proteins; D008934:Mitogens; D011720:Pyrazoles; D012333:RNA, Messenger; C096472:SCH 51344; D011493:Protein Kinase C