title: Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target.
abstract: In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls.
authors.affiliation: Universidad de Costa Rica, Escuela de Química, San José, Costa Rica.
authors.forename: V
authors.initials: V
authors.lastname: Castro
authors.forename: P
authors.initials: P
authors.lastname: Rüngeler
authors.forename: R
authors.initials: R
authors.lastname: Murillo
authors.forename: E
authors.initials: E
authors.lastname: Hernandez
authors.forename: G
authors.initials: G
authors.lastname: Mora
authors.forename: H L
authors.initials: HL
authors.lastname: Pahl
authors.forename: I
authors.initials: I
authors.lastname: Merfort
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002489:Central America; D006801:Humans; D019169:Jurkat Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008519:Medicine, Traditional; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D008517:Phytotherapy; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D016328:NF-kappa B; D012717:Sesquiterpenes