title: Rapid neutrophil response controls fast-replicating intracellular bacteria but not slow-replicating Mycobacterium tuberculosis.
abstract: Being one of the first cells to invade the site of infection, neutrophils play an important role in the control of various bacterial and viral infections. In the present work, the contribution of neutrophils to the control of infection with different intracellular bacteria was investigated. Mice were treated with the neutrophil-depleting monoclonal antibody RB6-8C5, and the time course of infection in treated and untreated mice was compared by using intracellular bacterial species and strains varying in virulence and replication rate. The results indicate that neutrophils are crucial for the control of fast-replicating intracellular bacteria, whereas early neutrophil effector mechanisms are dispensable for the control of the slow-replicating Mycobacterium tuberculosis.
authors.affiliation: Max-Planck-Institut für Infektionsbiologie, D-10117 Berlin, Germany. seiler@mpiib-berlin.mpg.de
authors.forename: P
authors.initials: P
authors.lastname: Seiler
authors.forename: P
authors.initials: P
authors.lastname: Aichele
authors.forename: B
authors.initials: B
authors.lastname: Raupach
authors.forename: B
authors.initials: B
authors.lastname: Odermatt
authors.forename: U
authors.initials: U
authors.lastname: Steinhoff
authors.forename: S H
authors.initials: SH
authors.lastname: Kaufmann
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007150:Immunohistochemistry; D008089:Listeria monocytogenes / Q000254:growth & development / Q000276:immunology; D008088:Listeriosis / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009161:Mycobacterium / Q000254:growth & development / Q000276:immunology; D009164:Mycobacterium Infections / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000254:growth & development* / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis; D016897:Respiratory Burst; D012481:Salmonella Infections, Animal / Q000276:immunology / Q000382:microbiology; D012486:Salmonella typhimurium / Q000254:growth & development / Q000276:immunology; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology
chemical_list: D000911:Antibodies, Monoclonal