Poly(vinylbenzyl chloride) microsphere synthesis and their chemical modifications.
Vinylbenzyl chloride (VBC) was dispersion polymerized to give monodisperse microspheres in the presence of poly(vinylpyrrolidone) (PVP) as a steric stabilizer. The effect of PVP concentration on the size and on microsphere stability during the polymerization process was investigated. Microsphere size was examined when co-stabilizer molecules were employed with PVP during the polymerization reaction. The built-in reactive chloromethyl groups of the microspheres were the sites of the nucleophilic reaction of two amino-group model molecules, glucosamine (G), a hexosamine implicated in processes of molecular recognition, and also bovine serum albumin (BSA). Elemental analyses and Fourier transform infrared spectroscopy (FTIR) spectra showed that poly(vinylpyrrolidone) was associated with the microsphere network. Elemental analyses, attenuated total reflection infrared spectroscopy (ATR-FTIR), and zeta potential measurements confirmed G and BSA links at the microsphere surface.
Dumistracel
I
I
Laboratoire de Pharmacie Galénique et de Biopharmacie, URA CNRS 1218, Université de Paris-Sud, Châtenay-Malabry, France. irinad@mail.dntis.ro
Ponchel
G
G
Danila
G
G
Duchêne
D
D
Carpov
A
A
D002214:Capsules / Q000138:chemical synthesis* / Q000737:chemistry; D004058:Diffusion; D004339:Drug Compounding; D005079:Excipients; D005612:Freeze Drying; D005944:Glucosamine / Q000737:chemistry; D007526:Isoelectric Point; D008970:Molecular Weight; D011108:Polymers; D011145:Polyvinyls / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D011719:Pyrazines; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013501:Surface-Active Agents
D002214:Capsules; D005079:Excipients; D011108:Polymers; D011145:Polyvinyls; D011719:Pyrazines; D013501:Surface-Active Agents; D012710:Serum Albumin, Bovine; C080604:polyvinylbenzyl chloride; D011205:Povidone; D005944:Glucosamine