The prophylactic effects of artemether against Schistosoma japonicum infections.
The fight against schistosomiasis in China has been very effective in reducing the number of infections across the country. However, the drug of choice, praziquantel, has no prophylactic effect, which reduces its efficacy in high transmission areas. This situation has prompted efforts to find prophylactic compounds, the most promising of which is the drug artemether. In this article, Xiao Shuhua, Mark Booth and Marcel Tanner review the results of laboratory tests and field trials of artemether against schistosomiasis in China.
Xiao
S H
SH
The Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai 200025, China.
Booth
M
M
Tanner
M
M
D000818:Animals; D000077549:Artemether; D037621:Artemisinins; D002681:China; D004285:Dogs; D011817:Rabbits; D012549:Schistosoma japonicum / Q000187:drug effects / Q000254:growth & development; D012554:Schistosomiasis japonica / Q000517:prevention & control*; D012556:Schistosomicides / Q000627:therapeutic use*; D012717:Sesquiterpenes / Q000627:therapeutic use*
D037621:Artemisinins; D012556:Schistosomicides; D012717:Sesquiterpenes; D000077549:Artemether