[Immunohistochemical and quantitative analysis of expression of basement membrane in squamous cell carcinoma of the oral cavity].
Fifty seven cases of oral squamous cell carcinoma (OSCC) were studied by immunohistochemical ABC method using type IV collagen and laminin antibodies and computer image analysis system to investigate the expression of basement membrane and its relation to clinicopathologic characteristics of the OSCC. The results demonstrated that: 1. in OSCC there were defects basement membrane in continuity of varying extents to complete loss of; 2. there was no correlation between the loss of basement membrane and tumor clinical stage (P > 0.05) by computer image analysis, while there was a highly significant correlation between the loss of basement membrane and histologic grading (P > 0.05). The well-differentiated tumor was associated with a low frequency of basement membrane loss. Therefore, the expression of basement membrane may be a useful parameter to evaluate tumor histologic differentiation.
Gu
X
X
Department of Stomatology, Hunan Medical University, Changsha.
Shen
Z
Z
Liu
S
S
D001485:Basement Membrane / Q000737:chemistry; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology; D003094:Collagen / Q000032:analysis*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis*; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D009367:Neoplasm Staging
D007797:Laminin; D003094:Collagen