title: Cerebral protection in severe brain injury: physiological determinants of outcome and their optimisation.
abstract: The primary role of intensive care in acute head injury lies in the prevention, detection and reversal of secondary neuronal injury. The maintenance of optimal systemic and cerebrovascular physiology can substantially contribute to these aims. There is, however, a role for novel neuroprotective interventions, many of which are currently under investigation.
authors.affiliation: Department of Anaesthesia, University of Cambridge Clinical School, Addenbrooke's Hospital, UK.
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
mesh_terms: D001930:Brain Injuries / Q000503:physiopathology / Q000628:therapy*; D003422:Critical Care / Q000379:methods*; D006706:Homeostasis; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods; D018696:Neuroprotective Agents / Q000627:therapeutic use; D011379:Prognosis; D012307:Risk Factors
chemical_list: D018696:Neuroprotective Agents