Selective oestrogen receptor modulation: molecular pharmacology for the millennium.
Knowledge of the mechanism of action and pharmacology of tamoxifen and raloxifene, for the prevention of breast cancer and osteoporosis respectively, has opened the door for the discovery of multifunctional medicines. There is now the potential to prevent osteoporosis, coronary heart disease, breast and endometrial cancer in postmenopausal women with elevated risk factors.
Levenson
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Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, Illinois 60611, USA.
Jordan
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VC
D001943:Breast Neoplasms / Q000737:chemistry* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*
D011960:Receptors, Estrogen