Transcriptional mechanisms in the development of motor control.
Considerable progress has been made in understanding how combinatorially expressed transcription factors control the development of neuronal subtypes in the fly and vertebrate central nervous systems. The mode of action of many of these factors has been conserved from invertebrates to vertebrates throughout evolution, such as the formation and regulation of specific transcriptional complexes, the utilization of repressors for maintaining specificity, and the use of phosphorylation as an important means for transiently altering transcriptional activity.
Jurata
L W
LW
Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, 92037, USA. ljurata@ems.salk.edu
Thomas
J B
JB
Pfaff
S L
SL
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004331:Drosophila melanogaster; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics / Q000502:physiology; D009046:Motor Neurons / Q000378:metabolism* / Q000502:physiology*; D010766:Phosphorylation; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D013997:Time Factors; D014158:Transcription, Genetic / Q000235:genetics*
D012097:Repressor Proteins