[The relationship between immunosuppression and oxygen free radicals in burned patients].
The serum immunosuppression effect and its relation to oxygen free radicals were studied in patients with thermal injury (n = 11, total body surface area 20%-83%). The serum MDA, sIL-2R increased significantly in burned patients (P < 0.01 all). The serum of burned patients depressed the IL-2 productin of normal human PBMC (P < 0.01). Antioxidants decreased the serum sIL-2R in burned patients and attenuated the suppressive effect IL-2 production of normal human PBMC (P < 0.05 all). The results suggest that oxygen free radicals participate in the serum immunosuppression effect in burned patients.
Xie
Y
Y
Department of Burn and Plastic Surgery, Xiangya Hospital, Hunan Medical University, Changsha.
Ma
E
E
Guo
S
S
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D002056:Burns / Q000097:blood / Q000276:immunology*; D005260:Female; D005609:Free Radicals; D006801:Humans; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000096:biosynthesis*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015375:Receptors, Interleukin-2 / Q000097:blood*; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D005609:Free Radicals; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D014810:Vitamin E; D008315:Malondialdehyde