title: Treatment and outcome of dogs with leptospirosis: 36 cases (1990-1998).
abstract: OBJECTIVE
  To characterize serologic and clinical features and outcome of dogs with leptospirosis that were treated conservatively (i.e., medical management alone) or with hemodialysis.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  36 dogs with leptospirosis.
  
  
  METHODS
  History; results of physical examinations, ultrasonography, and serologic, hematologic, and serum biochemical analyses; time to resolution of azotemia; and outcome were obtained from medical records. Dogs were treated conservatively (n = 22) or with hemodialysis (14).
  
  
  RESULTS
  Between 1990 and 1998, amount of rainfall was positively correlated with number of cases of leptospirosis identified per year. Serum antibodies against 6 Leptospira serovars were measured, and titers were highest to Leptospira pomona in 16 (44%) dogs, L bratislava in 9 (25%) dogs, and L hardjo in 1 (3%) dog. Eight (22%) dogs had equally high titers to L pomona and L bratislava, 1 (3%) had equally high titers to L grippotyphosa and L canicola, and 1 (3%) had high titers to L grippotyphosa, L pomona, L canicola, and L bratislava. During initial evaluation, all dogs were azotemic. Thirty (83%) dogs survived, including 12 of 14 (86%) dogs treated with hemodialysis and 18 of 22 (82%) treated conservatively. Serum creatinine concentration was similar in both groups after resolution of clinical signs.
  
  
  CONCLUSIONS
  Infection with L pomona and L bratislava was recognized as a cause of leptospirosis in dogs, and resulted in development of acute renal failure with various degrees of azotemia. Prognosis for dogs with mild to moderate azotemia was good with conservative treatment, whereas treatment with hemodialysis appeared to improve prognosis for dogs with severe azotemia.
authors.affiliation: Veterinary Medical Teaching Hospital, University of California, Davis 95616, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Adin
authors.forename: L D
authors.initials: LD
authors.lastname: Cowgill
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001772:Blood Cell Count / Q000662:veterinary; D001806:Blood Urea Nitrogen; D002140:California / Q000453:epidemiology; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D004285:Dogs; D005260:Female; D007668:Kidney / Q000000981:diagnostic imaging; D007919:Leptospira / Q000276:immunology; D007922:Leptospirosis / Q000150:complications / Q000453:epidemiology / Q000628:therapy / Q000662:veterinary*; D008297:Male; D011379:Prognosis; D011891:Rain; D006435:Renal Dialysis / Q000662:veterinary*; D012189:Retrospective Studies; D014463:Ultrasonography; D014511:Uremia / Q000209:etiology / Q000628:therapy / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D003404:Creatinine