title: Overview of clinical trials with MIT-MANUS: a robot-aided neuro-rehabilitation facility.
abstract: We are applying robotics and information technology to assist, enhance, and quantify neuro-rehabilitation. Our goal is a new class of interactive, user-affectionate clinical devices designed not only for evaluating patients, but also-for delivering meaningful therapy via engaging "video games". Notably, the novel robot MIT-MANUS has been designed and programmed for clinical neurological applications, and has undergone extensive clinical trials for more than four years at Burke Rehabilitation Hospital - White Plains, NY. This paper will review results of the first clinical trial of 20 patients, which showed that: - Stroke patients treated daily with additional robot-aided therapy during acute rehabilitation had improved outcome in motor activity at hospital discharge, when compared to a control group that received only standard acute rehabilitation treatment. - This improved outcome was sustained after three years. - The neuro-recovery process continued far beyond the commonly accepted 3 months post-stroke interval.
authors.affiliation: Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge MA 02139, USA. hikrebs@mit.edu
authors.forename: H I
authors.initials: HI
authors.lastname: Krebs
authors.forename: N
authors.initials: N
authors.lastname: Hogan
authors.forename: B T
authors.initials: BT
authors.lastname: Volpe
authors.forename: M L
authors.initials: ML
authors.lastname: Aisen
authors.forename: L
authors.initials: L
authors.lastname: Edelstein
authors.forename: C
authors.initials: C
authors.lastname: Diels
mesh_terms: D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009518:New York; D010291:Paresis / Q000209:etiology; D026741:Physical Therapy Modalities / Q000379:methods*; D020127:Recovery of Function; D012047:Rehabilitation Centers / Q000706:statistics & numerical data; D012371:Robotics / Q000379:methods* / Q000706:statistics & numerical data; D020521:Stroke / Q000150:complications / Q000523:psychology; D000071939:Stroke Rehabilitation; D016896:Treatment Outcome; D018910:Video Games / Q000523:psychology