title: Study of implanted biomaterial functionality by diphosphonate molecules labeled with radioactive 99mTc.
abstract: An implanted biomaterial can be transformed into young bone after some months, but it has not necessary reached full biofunctionality. Mineral concentration kinetics and crystal-structure studies, still being carried out in our group, are completed here by biofunctionality determinations. A natural coral is implanted in vivo at the cortical level of the femoral diaphyoff++ in rabbits. Diphosphonates molecules labeled with radioactive 99mTc are then injected in rabbits and the fixation of the radioactivity is analyzed in several sites for 8 mo after the implantation. Nuclear instruments and methods are used for the measurements. Four successive cycles of osseous remodeling are determined before reaching a biofunctional phase.
authors.affiliation: Laboratoire de Physique Corpusculaire de Clermont-Ferrand, Université Blaise Pascal, Aubière, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Irigaray
authors.forename: H
authors.initials: H
authors.lastname: Oudadesse
authors.forename: V
authors.initials: V
authors.lastname: Brun
authors.forename: P
authors.initials: P
authors.lastname: Labarre
authors.forename: M
authors.initials: M
authors.lastname: Rapp
authors.forename: J C
authors.initials: JC
authors.lastname: Madelmont
authors.forename: J
authors.initials: J
authors.lastname: Bonafous
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004164:Diphosphonates / Q000737:chemistry*; D015609:Organotechnetium Compounds / Q000737:chemistry*; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D004164:Diphosphonates; D015609:Organotechnetium Compounds