[Relationship between pregnancy loss and antiphospholipid antibody].
OBJECTIVE
To investigate the relationship between history of pregnancy loss and antiphospholipid antibodies (APA), including anticardiolipin (ACA) and lupus anti-coagulant antibodies (LA).


METHODS
Levels of serum APA, ACA and LA were determined by enzyme linked immunoabsorbent assay and activated partial thromboplastin time method respectively in 122 patients with history of unexplained pregnancy loss (study group) and 100 normal nonpregnant women (control group). The study group was further divided into three subgroups: embryo growth arrest (n = 23), stillbirth (n = 31), and recurrent abortion (n = 63).


RESULTS
The positive rates of APA, ACA, LA in the study group were significantly higher than those in controls (P < 0.05-0.001). The above significance was true in both stillbirth and recurrent abortion groups but not in embryo growth arrest group.


CONCLUSIONS
Levels of serum APA were associated with pregnancy loss, especially recurrent abortion and stillbirth. We suggested routine screening of serum APA should be performed in patients with history of fetal wastage for the sake of early treatment.
Zhang
X
X
First Hospital of Dalian Medical University.
Qian
M
M
Liu
S
S
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005313:Fetal Death / Q000276:immunology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D011247:Pregnancy
D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor