Chromosome 6p influences on different dyslexia-related cognitive processes: further confirmation.
In this study, which is a continuation and an extension of an earlier study, we enrolled two new families (N=31) and recruited more individuals from the previously ascertained families (N=56). The eight multiplex families (N=171) presented in this study were ascertained from a sample of adult probands whose childhood reading history is well documented through archival information. Six phenotypes were constructed to span a range of dyslexia-related cognitive processes. These phenotypes were (1) phonemic awareness (of spoken words); (2) phonological decoding (of printed nonwords); (3) rapid automatized naming (of colored squares or object drawings); (4) single-word reading (orally, of printed real words); (5) vocabulary; and (6) spelling (of dictated words). In addition, the diagnosis of lifelong dyslexia was established by clinical means. Genotyping was done with nine highly polymorphic markers from the 6p22.3-6p21.3 region. The results of two- and multipoint identity-by-descent and identity-by-state analyses supported the importance of a putative locus in the D6S464-D6S273 region for a number of dyslexia-related cognitive deficits.
Grigorenko
E L
EL
Department of Psychology, Yale University, New Haven, CT 06520, USA.
Wood
F B
FB
Meyer
M S
MS
Pauls
D L
DL
D000293:Adolescent; D000328:Adult; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D003071:Cognition; D004410:Dyslexia / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology*; D005192:Family Health; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D008957:Models, Genetic; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D011932:Reading; D015203:Reproducibility of Results; D018401:Sample Size; D012984:Software; D014825:Vocabulary