Nitroglycerin for rapid tocolysis: development of a protocol and a literature review.
OBJECTIVE
A protocol for nitroglycerin (NTG) use based on experiences with regard to new and previously described obstetric cases is presented. The efficacy of NTG tocolysis for obstetric emergencies is clinically evaluated.


METHODS
Hemodynamically stable parturients requiring acute tocolysis were treated with intravenous NTG and closely monitored. Clinical information was subsequently abstracted from medical records and compared with data from previous reviews.


RESULTS
Tocolytic treatment was successful in all cases (22 of 22, 100%). Complications were clinically insignificant. The most common problem was transient hypotension, which occurred in 9 of 22 (41%) cases.


CONCLUSIONS
NTG is an effective tocolytic with minimal complications, rapid onset, and a brief half-life. These characteristics favor its use during select obstetric procedures. However, strict adherence to protocols for administration is advised.
O'Grady
J P
JP
Department of Obstetrics and Gynecology, Tufts University School of Medicine, Baystate Medical Center, Springfield, MA 01199, USA. patrick.ogrady@bhs.org
Parker
R K
RK
Patel
S S
SS
D002985:Clinical Protocols; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007262:Infusions, Intravenous; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000009:adverse effects; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D011247:Pregnancy; D011256:Pregnancy Outcome; D015145:Tocolysis / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data*; D014590:Uterine Contraction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D014665:Vasodilator Agents; D005996:Nitroglycerin