Newer agents for hormonal contraception in the male.
Efforts to create a hormonal contraceptive for men use testosterone to suppress the production of pituitary gonadotropins and, hence, spermatogenesis. However, conventional testosterone must be administered by frequent injection, and when given alone, is not 100% effective. Therefore, newer androgens and agents that synergistically suppress gonadotropin production are being studied to create an effective and commercially viable contraceptive.
Amory
J K
JK
Population Center for Research in Reproduction, Department of Veterans Affairs, Puget Sound Health Care System, and Department of Medicine, University of Washington, Seattle, WA 98195-6420, USA.
Bremner
W J
WJ
D000728:Androgens / Q000494:pharmacology; D003267:Contraception / Q000379:methods*; D003272:Contraceptive Agents, Male / Q000494:pharmacology; D004357:Drug Synergism; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D011372:Progestins / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D003272:Contraceptive Agents, Male; D011372:Progestins; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone