title: Hematologic study of newborn umbilical cord blood.
abstract: Hematological parameters in newborn umbilical cord blood samples (n = 476), collected at the Hospital Provincial del Centenario, Rosario, were studied. They were divided into 3 groups: (I) full term newborns with weight according to gestational age; (II) low weight and normal gestational age; (III) preterm newborns. The results were as follows: group (I) Hb: 15.5 +/- 1.1 g/dl; RBC; 4.66 +/- 0.33 x 10(12)/l; PCV: 49% +/- 4.3%, MCV 105.1 +/- 5.3 fl; MHC: 33.2 +/- 1.2 pg. Decreased Hb concentration (p < 0.05) and increased MCV (p < 0.01) were observed in preterm newborns in comparison with normal ones, and a slight PCV increase and RBC values in low weight newborns compared to the control group (p < 0.05). Erythrocyte morphology was normal as well as reticulocyte values in these samples. The electrophoretic pattern was (FA) with the following Hb F values 66.3 +/- 6.8%, and Hb A2 0.45 +/- 0.3% in group (I), with a significant increase of Hb F in 30-35 weeks preterm newborns. Group (I) values are considered as normal hematological parameters in newborns in our country, whereas MCV < 94.7 fl is considered as a neonatal microcytosis marker, consequently an alert to investigate alpha-thalassemia. There was no influence on Hb concentration due to maternal smoking habit. The present work could be of relevance for our region since up to the present time there are no similar records.
authors.affiliation: Departamento Bioquímica Clínica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.
authors.forename: N I
authors.initials: NI
authors.lastname: Noguera
authors.forename: G
authors.initials: G
authors.lastname: Detarsio
authors.forename: S M
authors.initials: SM
authors.lastname: Pérez
authors.forename: I M
authors.initials: IM
authors.lastname: Bragós
authors.forename: O
authors.initials: O
authors.lastname: Lanza
authors.forename: J H
authors.initials: JH
authors.lastname: Rodríguez
authors.forename: I
authors.initials: I
authors.lastname: Acosta
authors.forename: R
authors.initials: R
authors.lastname: Davoli
authors.forename: A C
authors.initials: AC
authors.lastname: Milani
mesh_terms: D004909:Erythrocyte Indices; D004912:Erythrocytes; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005319:Fetal Hemoglobin / Q000032:analysis; D006400:Hematocrit; D006443:Hemoglobin A2 / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D011446:Prospective Studies
chemical_list: D006454:Hemoglobins; D006443:Hemoglobin A2; D005319:Fetal Hemoglobin