Nonclassical effects of 1alpha,25-dihydroxyvitamin D(3) and its analogs.
The activated form of vitamin D(3), 1alpha,25(OH)(2)D(3), not only plays a central role in bone and calcium metabolism but has also potent antiproliferative and prodifferentiating effects. Moreover, the combined presence of 25(OH)D(3)-1alpha-hydroxylase as well as the vitamin D receptor in several tissues introduced the idea of a paracrine role for 1alpha,25(OH)(2)D(3). By introducing chemical modifications into the flexible parent molecule 1alpha,25(OH)(2)D(3), a whole generation of vitamin D analogs was created. Due to a clear dissociation of the antiproliferative and prodifferentiating effects from calcemic effects, these analogs can be used not only for the treatment of bone disorders but also for non-classical applications.
Verstuyf
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A
Laboratorium voor Experimentele Geneeskunde en Endocrinologie (Legendo), Katholieke Universiteit Leuven, Belgium.
Verlinden
L
L
Segaert
S
S
Van Etten
E
E
Mathieu
C
C
Bouillon
R
R
D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy
D002117:Calcitriol; D002118:Calcium