Antigen processing and presentation by intestinal epithelial cells - polarity and complexity.
The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa
Hershberg
R M
RM
Divisions of Gastroenterology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Mayer
L F
LF
D000818:Animals; D017951:Antigen Presentation; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016764:Cell Polarity; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology* / Q000276:immunology*; D008954:Models, Biological
D000949:Histocompatibility Antigens Class II