alpha-Substituted N-(sulfonamido)alkyl-beta-aminotetralins: potent and selective neuropeptide Y Y5 receptor antagonists.
Youngman
M A
MA
Drug Discovery, The R. W. Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, Pennsylvania 19477, USA.
McNally
J J
JJ
Lovenberg
T W
TW
Reitz
A B
AB
Willard
N M
NM
Nepomuceno
D H
DH
Wilson
S J
SJ
Crooke
J J
JJ
Rosenthal
D
D
Vaidya
A H
AH
Dax
S L
SL
D002460:Cell Line; D006801:Humans; D011869:Radioligand Assay; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D014162:Transfection
D017476:Receptors, Neuropeptide Y; D013449:Sulfonamides; D013764:Tetrahydronaphthalenes; C100568:neuropeptide Y5 receptor