[Determination of valaciclovir polybutylcyanoacrylate nanoparticles].
The valaciclovir content of polybutylcyanoacrylate nanoparticles was determined by HPLC after dissolving the valaciclovir-poly butylcyanoacrylate nanoparticles in a solvent mixture. ODS-C18 column was used. The mobile phase consisted of CH3OH-0.02 mol/L KH2PO4 (20:80). The linear range was 2.02-20.20 micrograms/ml; the recovery 97.30%, and RSD 4.90%. This method is accurate and can be used for determining the contents of other nanoparticles.
He
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Q
Department of Pharmaceutics, School of Pharmacy, Chengdu.
Zhang
Z
Z
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000032:analysis; D000998:Antiviral Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004659:Enbucrilate / Q000737:chemistry; D000077483:Valacyclovir; D014633:Valine / Q000031:analogs & derivatives* / Q000032:analysis
D000998:Antiviral Agents; D004659:Enbucrilate; D014633:Valine; D000077483:Valacyclovir; D000212:Acyclovir