[The use of angiotensin-converting enzyme inhibitors in patients with chronic glomerulonephritis].
Results are analyzed of a prolonged treatment with inhibitors of the angiotensin-converting enzyme (captopril, Capoten, 100 to 150 mg daily, Renitec, 10 to 20 mg daily) in 53 patients with chronic glomerulonephritis. Of these, 23 patients presented with nephrotic syndrome in prehypertensive stage, 30 were in the stage of chronic renal insufficiency. The time-related course of proteinemia was studied as were indices for systemic hemodynamics, azotemia. Shown in the study was a significant effect of ACE inhibitors on proteinuria, indicators of systemic hypertension. A tendency toward decline in indices for creatinemia was noted. A concept is considered of multifactor effect of ACE inhibitors resulting in inhibition of progression of renal insufficiency.
Dudar
I O
IO
D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use*; D002908:Chronic Disease; D004656:Enalapril / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000175:diagnosis / Q000188:drug therapy; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril; D002216:Captopril