Engineering biosynthetic pathways: new routes to chiral amino acids.
The engineering of microbial biosynthetic pathways is advancing rapidly because of new molecular genetic approaches, sophisticated analysis of metabolic flux and the rapid sequencing of diverse bacterial genomes. The classical methods of mutagenesis/selection, originally applied in the development of amino-acid-over-producing bacteria are now being complemented by an increasingly rational strategy.
Fotheringham
I
I
Biosciences, NSC Technologies, Mount Prospect, IL 60056, USA. Ifotheri@glcc.com.
D000596:Amino Acids / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D015202:Protein Engineering; D013237:Stereoisomerism
D000596:Amino Acids