Microtubule dynamics and tubulin interacting proteins.
Microtubule dynamics are crucial in generation of the mitotic spindle. During the transition from interphase to mitosis, there is an increase in the frequency of microtubule catastrophes. Recent work has identified two proteins, Op 18/stathmin and XKCM1, which can promote microtubule catastrophes in vitro and in cells or extracts. Although both of these proteins share the ability to bind tubulin dimers, their mechanisms of action in destabilizing microtubules are distinct.
Walczak
C E
CE
Medical Science, Indiana University, Bloomington, IN 47405, USA. cwalczak@indiana.edu
D000818:Animals; D019281:Dimerization; D016547:Kinesins / Q000378:metabolism*; D008868:Microtubule Proteins; D008870:Microtubules / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D050777:Stathmin; D014404:Tubulin / Q000378:metabolism*; D029867:Xenopus Proteins
C088335:KIF11 protein, Xenopus; D008868:Microtubule Proteins; D010750:Phosphoproteins; D050777:Stathmin; D014404:Tubulin; D029867:Xenopus Proteins; D016547:Kinesins