title: Color as an indicator of the organization and compactibility of binary powder mixes.
abstract: The aim of this study was to relate the color of several binary mixes to their organization as observed by scanning electronic microscopy, and to their compactibility. Binary mixes of niflumic acid (yellow) with ethyl cellulose, hydroxypropylmethylcellulose, low-substituted hydroxypropylcellulose (L-HPC), and ibuprofen (all white) were prepared using different particle size ranges. Colors of the mixes were determined by diffuse reflectance spectroscopy using a chromameter. Linear correlation was observed between the yellowness index/whiteness index ratio (Y/W ratio) defined by the American Society for Testing and Materials (ASTM) standards and the mean particle size difference of the materials which governs the organization of the blend. Except for the least interacting mix, the niflumic acid/L-HPC series, the color of the blend was also related to the tensile strength of the tablets made from the binary mixes. Color could be an interesting indicator of the organization of a powder mix. Diffuse reflectance spectroscopy could be used as a quality control tool because any modification of the color of the mix may be an indicator of a modification of its compactibility.
authors.affiliation: School of Pharmacy, University of Geneva, Switzerland. jerome.barra@Firmenich.com
authors.forename: J
authors.initials: J
authors.lastname: Barra
authors.forename: A
authors.initials: A
authors.lastname: Ullrich
authors.forename: F
authors.initials: F
authors.lastname: Falson-Rieg
authors.forename: E
authors.initials: E
authors.lastname: Doelker
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003116:Color / Q000592:standards*; D003124:Colorimetry; D007052:Ibuprofen / Q000737:chemistry; D007785:Lactose / Q000031:analogs & derivatives / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009544:Niflumic Acid / Q000737:chemistry; D010078:Oxazines; D010316:Particle Size; D011208:Powders; D013057:Spectrum Analysis; D013499:Surface Properties / Q000187:drug effects; D013607:Tablets / Q000138:chemical synthesis*; D013718:Tensile Strength
chemical_list: D010078:Oxazines; D011208:Powders; D013607:Tablets; D009544:Niflumic Acid; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose; D007052:Ibuprofen