title: Physiologic and molecular alterations in carbohydrate metabolism during pregnancy and gestational diabetes mellitus.
abstract: Recent progress suggests that postreceptor mechanisms that contribute to insulin resistance of pregnancy appear to be multifactorial, but are exerted at the beta-subunit of the insulin receptor and at the level of IRS-1. Gestational diabetes mellitus represents the combination of acquired and intrinsic abnormalities of insulin action. The resistance to insulin-mediated glucose transport appears to be greater in skeletal muscle from GDM subjects than from pregnancy alone. There is also a modest but significant decrease in maximal insulin receptor tyrosine phosphorylation in muscle from obese GDM subjects. Results also suggest that increased insulin receptor serine/threonine phosphorylation and PC-1 could underlie the insulin resistance of pregnancy and pathogenesis of GDM. Whether additional defects are exerted further downstream from IRS-1 remains to be investigated.
authors.affiliation: Department of Nutrition, Case Western Reserve University, School of Medicine 44106-4935, USA.
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: J
authors.initials: J
authors.lastname: Shao
authors.forename: J E
authors.initials: JE
authors.lastname: Friedman
mesh_terms: D016640:Diabetes, Gestational / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism*; D005260:Female; D006801:Humans; D006946:Hyperinsulinism; D007333:Insulin Resistance; D011247:Pregnancy / Q000378:metabolism*
chemical_list: D004040:Dietary Carbohydrates