A comparison of estimators of the population recombination rate.
Three new estimators of the population recombination rate C = 4Nr are introduced. These estimators summarize the data using the number of distinct haplotypes and the estimated minimum number of recombination events, then calculate the value of C that maximizes the likelihood of obtaining the summarized data. They are compared with a number of previously proposed estimators of the recombination rate. One of the newly proposed estimators is generally better than the others for the parameter values considered here, while the three programs that calculate maximum-likelihood estimates give conflicting results.
Wall
J D
JD
Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA. jdwall@midway.uchicago.edu
D000818:Animals; D005828:Genetics, Population; D006801:Humans; D011995:Recombination, Genetic