[Prevention of acute hepatic failure after "90%" hepatectomy by portal branch ligation in rats].
In this study, ligation of portal branches feeding 90% liver mass was performed in rats. After the ligation, 10% liver mass with portal blood perfusion underwent a progressive hypertrophy. It gained weight against the control by about 5-fold at the 14th day. The measurement of incorporation rate of H3-thymidine showed that the DNA synthesis increased rapidly in the liver tissue keeping portal blood supply. It reached a peak at 24 hours and retumed to normal at 7 days after the ligation. The ligated liver lobes under-went an atrophy gradually. With the pretreatment of such portal branch ligation 2 weeks before, 80% rats survived from the resection of ligated liver lobes which composed of 90% preceding liver mass. In the control group of sham portal branch ligation, all rats died within a short period of time after 90% hepatectomy. This study demonstrated that a secondary extended hepatectomy following the ligation of portal branches feeding 90% liver mass could prevent acute hepatic failure induced by primary 90% hepatectomy in rats.
Li
B
B
Department of Surgery, First Affiliated Hospital, Chengdu.
Saliez
A
A
Lambotte
L
L
D000818:Animals; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods; D008026:Ligation; D017114:Liver Failure, Acute / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D011169:Portal Vein / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar