Anaplastic carcinoma of the pancreas with rhabdoid features.
The malignant rhabdoid tumor (MRT) is histologically characterized by the invasive proliferation of polygonal to ovoid cells with abundant eosinophilic cytoplasm and eccentric vesicular nuclei with a prominent nucleolus. MRT frequently occurs in the kidney, but may also arise in other organs. However, MRT should be strictly distinguished from carcinomas with rhabdoid features. A post-mortem examination of a 68-year-old woman found an anaplastic carcinoma of the pancreas with rhabdoid features displaying extensive invasion into the neighboring tissues. To the best of our knowledge, this is the first case of a pancreatic tumor with rhabdoid features. Pathologists should consider that carcinomas showing rhabdoid features may also appear in the pancreas. As pancreatic tumors with rhabdoid features have characteristic histopathological features and poor prognosis compared to other pancreatic tumors, careful histopathological differential diagnosis is important.
Kuroda
N
N
First Department of Pathology, Kochi Medical School, Kochi, Japan.
Sawada
T
T
Miyazaki
E
E
Hayashi
Y
Y
Toi
M
M
Naruse
K
K
Fukui
T
T
Nakayama
H
H
Hiroi
M
M
Taguchi
H
H
Enzan
H
H
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007382:Intermediate Filaments / Q000648:ultrastructure; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology*; D018335:Rhabdoid Tumor / Q000737:chemistry / Q000473:pathology*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins