Integrin signalling: a new Cas(t) of characters enters the stage.
Cellular morphology is determined by the organization of the intracellular actin cytoskeleton, which is influenced by external and internal cues. Focal adhesions are sites at which the actin cytoskeleton is linked to the extracellular matrix by integrin receptor complexes. In addition to providing structural tethering points for cells, integrin receptor complexes transduce signals that influence a broad range of cellular processes, including migration, proliferation, transformation and apoptosis. The Cas proteins (p130Cas, HEF1/Cas-L and Efs/Sin), a family of docking proteins containing multiple interaction domains, are important components of integrin receptor signalling and have been implicated in all of these processes.
O'Neill
G M
GM
Fox Chase Cancer Center, Division of Basic Science, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.
Fashena
S J
SJ
Golemis
E A
EA
D000199:Actins / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D016923:Cell Death / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D048429:Cell Size / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D050719:Crk-Associated Substrate Protein; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011506:Proteins; D050717:Retinoblastoma-Like Protein p130; D015398:Signal Transduction / Q000502:physiology*
D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; C493841:BCAR1 protein, human; D050719:Crk-Associated Substrate Protein; C484351:EFS protein, human; D016023:Integrins; C099942:NEDD9 protein, human; D010750:Phosphoproteins; D011506:Proteins; D050717:Retinoblastoma-Like Protein p130