Search for an IgG response against neural antigens in experimental spinal cord injury.
In order to determine if a specific response is induced after spinal cord injury, we performed a kinetic search for IgG antibodies against various spinal cord antigenic preparations in a rat contusion model. Even though spinal cord injured animals showed two reactive bands, these could be originated by the reaction of natural antibodies, since they were also observed before lesion. Thus, these antibodies would not be of relevance in the pathogenic events of spinal cord injury in this rat model. Our findings do not demonstrate the existence of a specific IgG response against spinal cord constituents after injury.
Ibarra
A
A
Instituto Nacional de Diagnóstico y Referencia Epidemiológicos (INDRE), SSA, México D.F., Mexico.
Martinez
S
S
Reyes
J
J
Meza-Lucas
A
A
Mandujano
A
A
Grijalva
I
I
Madrazo
I
I
Correa
D
D
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D003288:Contusions / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D004676:Myelin Basic Protein / Q000276:immunology; D051381:Rats; D020318:Rats, Long-Evans; D013116:Spinal Cord / Q000276:immunology*; D013119:Spinal Cord Injuries / Q000276:immunology*
D000941:Antigens; D001323:Autoantibodies; D007074:Immunoglobulin G; D004676:Myelin Basic Protein