Dopamine-transporter density in nucleus accumbens of type-1 alcoholics.
We have shown that alcoholic patients have a lower number of dopamine transporters in the nucleus accumbens, which mediates the rewarding effects of addictive drugs. Thus, certain dopaminergic agents may be beneficial in the treatment of alcohol withdrawal and in the long-term treatment of alcoholism with selective use.
Tupala
E
E
Hall
H
H
Särkioja
T
T
Räsänen
P
P
Tiihonen
J
J
D000437:Alcoholism / Q000378:metabolism*; D001345:Autoradiography; D002352:Carrier Proteins / Q000032:analysis*; D004298:Dopamine / Q000032:analysis*; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009714:Nucleus Accumbens / Q000737:chemistry*
D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D004298:Dopamine