title: Estrogen receptor variants are present in many normal human tissues.
abstract: Estrogen receptors (ER) are present in various reproductive tissues as well as in other tissues not considered classical targets for estrogen. A variety of alternatively spliced ER variants which co-exist with the wild-type receptor has also been described in many tissues. We analyzed the presence of both wild-type and variant receptors from normal human tissues of various origin using semi-nested PCR and direct automated sequence of the amplified products. We demonstrate that many normal human tissues of various origin contain a number of spliced variants of the estrogen receptor that co-exist with the wild-type receptor. Variants lacking exons 2, 4, 5, and 7 are detected in a variety of normal human tissues.
authors.affiliation: Cancer Research Laboratory, 491 LSA, University of California, Berkeley, CA 94720, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: S K
authors.initials: SK
authors.lastname: Chiou
authors.forename: R
authors.initials: R
authors.lastname: Guzman
authors.forename: S
authors.initials: S
authors.lastname: Nandi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005091:Exons; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D011960:Receptors, Estrogen