["Non-solvent shock agglomeration technology" as a new alternative method for work on ibuprofen. 4. Production and evaluation of quick release forms].
During compaction of shock-agglomerated S(+)ibuprofen it was of interest if and how far the sometimes strongly differing quality or the origin of the source material has effects on the tabletting properties and on tablet quality. Moreover, conventional and shock agglomerated substances are compared with regard to the parameters mentioned. The technology of "non-solvent shock agglomeration" results in substances suitable for direct tabletting. Additionally, the resulting comprimates have characteristics which can be clearly traced back to the special quality of the ibuprofen-shock agglomerates. By using different agents in the process of substance preparation specific galenic properties can be achieved.
Möller
T
T
Institut für Pharmazeutische Technologie, Karl-Franzens-Universität Graz, Austria.
Korsatko
W
W
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000032:analysis; D004339:Drug Compounding; D005079:Excipients; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000008:administration & dosage* / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D011208:Powders; D012995:Solubility; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D011208:Powders; D013607:Tablets; D007052:Ibuprofen