title: Flutamide suppressed prostate hypertrophy in rats and mice.
abstract: OBJECTIVE
  To study the suppressive effect of flutamide (Flu) on benign prostate hypertrophy.
  
  
  METHODS
  The effect of Flu 10, 25, and 50 mg.kg-1 i.g. on the prostate was tested in orchiectomized rats with s.c. testosterone daily for 30 d and in mice implanted with homologous strain fetal mouse urogenital sinus for 14 d.
  
  
  RESULTS
  1) Flu dose-dependently suppressed the weight and volume of each lobe of the prostate to about 10%-50% of control. Also, the acini and height of epithelial cells atrophied. The effect was more powerful than that of estradiol (Est). 2) The weight and volume of the mouse prostate diminished in Flu-treated groups, but the dose-response relationship was seen only in volume. In this model, Est was better than Flu.
  
  
  CONCLUSIONS
  Flu possesses the suppressive action on benign prostate hypertrophy.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zhang
authors.forename: P F
authors.initials: PF
authors.lastname: Li
authors.forename: B L
authors.initials: BL
authors.lastname: Chen
authors.forename: D
authors.initials: D
authors.lastname: Li
mesh_terms: D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005485:Flutamide / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000726:Androgen Antagonists; D004958:Estradiol; D005485:Flutamide