title: [Intraperitoneal cisplatin plus epinephrine and surgical debulking for the treatment of advanced peritoneal carcinomatosis in the rat].
abstract: OBJECTIVE
  To evaluate and compare the effects of cytoreductive surgery with intraperitoneal cisplatin and epinephrine on peritoneal carcinomatosis in the rat.
  
  
  METHODS
  Twenty-day old peritoneal carcinomatosis was obtained after intraperitoneal injection of 1 x 10(6) DHD/K12/PROb cells into BDIX rats. The surgical treatment included electric fulguration of the peritoneal tumors with spleen and omentum removal while intraperitoneal chemotherapy included platinum (3 mg/kg) associated with epinephrine (2 mg/kg).
  
  
  RESULTS
  Surgery did not increase rat survival unlike cisplatin or cisplatin/epinephrine chemotherapy. Intraperitoneal chemotherapy alone with cisplatin +/- epinephrine increased survival but did not provide cure. Surgery followed by intraperitoneal cisplatin and epinephrine cured four out of five twenty-day old peritoneal carcinomatosis.
  
  
  CONCLUSIONS
  Surgery combined with intraperitoneal cisplatin and epinephrine could be an efficient treatment for peritoneal carcinomatosis in man.
authors.affiliation: Unité INSERM 517, Facultés de Médecine et Pharmacie, Dijon.
authors.forename: L
authors.initials: L
authors.lastname: Benoit
authors.forename: C
authors.initials: C
authors.lastname: Duvillard
authors.forename: J L
authors.initials: JL
authors.lastname: Beltramo
authors.forename: P
authors.initials: P
authors.lastname: Brunet-Lecomte
authors.forename: B
authors.initials: B
authors.lastname: Chauffert
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000601:surgery*; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004837:Epinephrine / Q000627:therapeutic use*; D005260:Female; D008297:Male; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D051381:Rats; D011919:Rats, Inbred Strains; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014662:Vasoconstrictor Agents; D002945:Cisplatin; D004837:Epinephrine