title: The use of a hydrophobic matrix for the sustained release of a highly water soluble drug.
abstract: An experimental investigation into the use of a hydrophobic matrix to control the release of a highly water soluble drug was undertaken. Matrices consisting of hydrogenated vegetable oil and calcium sulfate with a 4% drug loading showed a sustained-release profile of up to 24 hr. The release mechanism from such matrices seemed to obey both root time kinetics and first-order behavior. Investigations showed that the effect of geometry had a significant effect on the drug release rate.
authors.affiliation: Smithkline Beecham Pharmaceuticals, Pharmaceutical Technologies Department, Harlow, Essex, United Kingdom.
authors.forename: L G
authors.initials: LG
authors.lastname: Martini
authors.forename: M
authors.initials: M
authors.lastname: Coles
authors.forename: K
authors.initials: K
authors.lastname: Gravell
authors.forename: S
authors.initials: S
authors.lastname: Stephenson
authors.forename: C M
authors.initials: CM
authors.lastname: Thomson
mesh_terms: D000465:Algorithms; D002133:Calcium Sulfate / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D005079:Excipients / Q000737:chemistry*; D010938:Plant Oils; D012995:Solubility; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D010938:Plant Oils; D013607:Tablets; D002133:Calcium Sulfate