Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives.
Thirteen 3-substituted benzothiazolone derivatives have been synthesized. Their chemical structures have been elucidated by IR and NMR spectral data and by elemental analyses. Among these compounds, 1-¿3-[2(3H)-benzothiazolon-3-yl[propanoyl]morpholine (5b); 1-¿3-[2(3H)-benzothiazolon-3-yl[propanoyl]-4-benzylpiperidine++ + (5c); 1-¿3-[2(3H)-benzothiazolon-3-yl[-propanoyl]-4-phenylpiperazine (5d); 3-[3-(4-benzylpiperidine-1-yl)propyl]-2(3H)-benzothiazolone (5k); 3-[3-(4-benzylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5I); 3-[3-(4-phenylpiperazine-1-yl)propyl]-2(3H)-benzothiazolone (5m) have been found to be significantly more active than the others.
Cakir
B
B
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Hipodrom, Ankara, Turkey.
Ulucay
A
A
Dogruer
D S
DS
Isimer
A
A
Sahin
M F
MF
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D005260:Female; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D018712:Analgesics, Non-Narcotic; D013844:Thiazoles