Interferon-alpha-associated development of bullous lesions in mycosis fungoides.
We report a 67-year-old woman with mycosis fungoides (MF) who was receiving subcutaneous injections of recombinant interferon alpha-2b (IFN-alpha). After 2 months of IFN-alpha treatment, bullous lesions appeared on her trunk and extremities. A skin biopsy specimen from the trunk revealed histopathologic features of bullous MF. Bullous lesions with specific infiltrates of MF are very rare; to the best of our knowledge, this is the first case showing specific bullous lesions of MF developed under IFN-alpha treatment.
Pföhler
C
C
Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany.
Ugurel
S
S
Seiter
S
S
Wagner
A
A
Tilgen
W
W
Reinhold
U
U
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects* / Q000627:therapeutic use; D009182:Mycosis Fungoides / Q000188:drug therapy*; D011994:Recombinant Proteins; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D007370:Interferon Type I; D011994:Recombinant Proteins