HLA-DMA allele polymorphism: no impact on kidney allograft outcome.
The purpose of this study was to analyze the association of HLA-DMA alleles with rejection episodes and early graft loss (EGL) in renal transplant recipients. One hundred and eighty four HLA-DMA alleles were retrospectively analyzed by DNA sequence analysis in 92 kidney transplant recipients. The gene frequencies of HLA-DMA *0101, *0102, *0103 and *0104 were found to be similar in all recipients, regardless of rejection vs non rejection episodes and EGL incidence. In conclusion, HLA-DMA allele polymorphism did not impact renal allograft outcome.
Saadeh
E
E
Austin Diagnostic Clinic, Austin, TX, USA.
Szatkowski
M
M
Vary
C P
CP
Smith
J D
JD
Himmelfarb
J
J
Mahoney
R J
RJ
D000483:Alleles; D006084:Graft Rejection / Q000276:immunology*; D006681:HLA-D Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008281:Maine; D011110:Polymorphism, Genetic; D012189:Retrospective Studies; D017422:Sequence Analysis, DNA; D014184:Transplantation, Homologous; D016896:Treatment Outcome
C416189:H2-M antigens; D006681:HLA-D Antigens; C084245:HLA-DM antigens; D000949:Histocompatibility Antigens Class II