Molecular determinants of drug resistance in tuberculosis.
Rapid detection of drug-resistant tuberculosis (TB) has become increasingly important in the era of pandemic human immunodeficiency virus infection and antibiotic resistance. The identification of the molecular correlates of antibiotic resistance in Mycobacterium tuberculosis have engendered the development of DNA-based assays for the identification of drug-resistant TB. This review summarizes the recent discoveries concerning resistance to isoniazid, rifampin, pyrazinamide, ethambutol, streptomycin, amikacin, kanamycin and the quinolones.
Riska
P F
PF
State University of New York-Health Science Center at Brooklyn, New York, USA.
Jacobs
W R
WR
Alland
D
D
D000995:Antitubercular Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics*; D014376:Tuberculosis / Q000188:drug therapy / Q000235:genetics*; D018088:Tuberculosis, Multidrug-Resistant / Q000235:genetics
D000995:Antitubercular Agents