Morphological alterations of the choroid plexus in late-onset Alzheimer's disease.
Anomalies of the cerebrospinal fluid flow rate and composition that have been reported in patients suffering from Alzheimer's disease (AD) could be related to alterations of the choroid plexuses (CD). Here we report a photonic and electron morphometric study in which we compared the height of CP epithelial cells and the thickness of their basement membrane on post-mortem samples from AD patients, age-matched controls and two newborns. Ageing appeared associated with epithelial atrophy and basement membrane thickening, but these features were significantly accentuated in AD. These data suggest that a dramatic alteration of the secretion and filtration could be involved in the multiparametric pathogenesis of late-onset AD.
Serot
J M
JM
Laboratoire d'Immunologie (GRIP, JE DRED 251) Faculté de Médecine, UHP Nancy I, France.
Béné
M C
MC
Foliguet
B
B
Faure
G C
GC
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D002831:Choroid Plexus / Q000473:pathology* / Q000648:ultrastructure; D004847:Epithelial Cells / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D008875:Middle Aged; D012016:Reference Values; D013398:Sudden Infant Death / Q000473:pathology