title: Are there proliferating neuronal precursors in adult rat dorsal root ganglia?
abstract: The origin of new neurons in dorsal root ganglia of adult rat was investigated using an experimental model in which postnatal neurogenesis naturally occurring is enhanced and restricted in a brief period of life. Possible mitotic origin of new neurons was investigated by means of 5-bromo-2-deoxyuridine, anti-NF 200 antibody was used to detect if proliferated cells showed a neuronal phenotype. The results suggest that postnatal neurogenesis in dorsal root ganglia could depend only in part on precursor proliferation and that normally new neurons derive from the late differentiation of postmitotic cells.
authors.affiliation: Institute of Morphological Sciences, University of Urbino, Crocicchia, I-61029, Urbino, Italy. s.ciaroni@uniurb.it
authors.forename: S
authors.initials: S
authors.lastname: Ciaroni
authors.forename: T
authors.initials: T
authors.lastname: Cecchini
authors.forename: R
authors.initials: R
authors.lastname: Cuppini
authors.forename: P
authors.initials: P
authors.lastname: Ferri
authors.forename: P
authors.initials: P
authors.lastname: Ambrogini
authors.forename: C
authors.initials: C
authors.lastname: Bruno
authors.forename: P
authors.initials: P
authors.lastname: Del Grande
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism; D002455:Cell Division; D002467:Cell Nucleus / Q000737:chemistry / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005727:Ganglia, Spinal / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D008297:Male; D016900:Neurofilament Proteins / Q000032:analysis; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016900:Neurofilament Proteins; C051774:neurofilament protein H; D001973:Bromodeoxyuridine