Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species.
Yanucamides A (1) and B (2) were isolated from the lipid extract of a Lyngbya majuscula and Schizothrixsp. assemblage collected at Yanuca Island, Fiji. The structures of compounds 1 and 2 were determined by spectroscopic methods. Both compounds contain a unique 2,2-dimethyl-3-hydroxy-7-octynoic acid, which has previously been described only as a component of kulolide-1 (3) and kulokainalide-1 (4), metabolites from the marine mollusk Philinopsis speciosa. Thus, the isolation of the yanucamides from this cyanobacterial assemblage supports the hypothesis that the kulolides and related metabolites are of cyanobacterial origin.
Sitachitta
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College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
Williamson
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Gerwick
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D000818:Animals; D001156:Artemia; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides; D005367:Fiji; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008974:Mollusca; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D016339:Spectrometry, Mass, Fast Atom Bombardment
D047630:Depsipeptides; D010456:Peptides, Cyclic; C406625:yanucamide A; C406626:yanucamide B