title: Oral gastrografin in neonates: a note of caution.
abstract: Hyperosmolar feeds are known to increase gastrointestinal permeability, predisposing to absorption of toxins. They are also associated with necrotising enterocolitis (NEC) in neonates. A case of a neonate with suspected NEC who died following Gram-negative septicaemia possibly related to oral gastrografin is reported. Hyperosmolarity of gastrografin may have caused complete loss of mucosal integrity in the compromised bowel leading to Gram-negative septicaemia.
authors.affiliation: Department of Neonatology, Kirwan Hospital for Women, Townsville, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Tuladhar
authors.forename: A
authors.initials: A
authors.lastname: Daftary
authors.forename: S K
authors.initials: SK
authors.lastname: Patole
authors.forename: J S
authors.initials: JS
authors.lastname: Whitehall
mesh_terms: D016470:Bacteremia / Q000139:chemically induced*; D003287:Contrast Media / Q000009:adverse effects* / Q000737:chemistry; D003974:Diatrizoate Meglumine / Q000009:adverse effects*; D020345:Enterocolitis, Necrotizing / Q000139:chemically induced*; D017809:Fatal Outcome; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007454:Iodides / Q000009:adverse effects* / Q000737:chemistry; D009994:Osmolar Concentration
chemical_list: D003287:Contrast Media; D007454:Iodides; D003974:Diatrizoate Meglumine