title: Vzg-1/lysophosphatidic acid-receptor involved in peripheral pain transmission.
abstract: The nociception by intraplantar (i.pl.) lysophosphatidic acid (LPA) injection was significantly, but partially blocked when mice received intrathecal (i.t.) antisense oligodeoxynucleotide treatment for the vzg-1 type LPA-receptor. The residual LPA-nociception observed under the condition of pertussis toxin-treatment, which is expected to block presynaptic contribution, was abolished by diphenhydramine (i.pl.), an H1-type histamine receptor antagonist. Taking into account that vzg-1 mRNA was detected in the dorsal root ganglion by RT-PCR method, these findings suggest that the LPA-induced nociception is attributed to the mechanism through vzg-1 receptor on nociceptor endings, and to that through unidentified LPA-receptor on peripheral, possibly mast cells.
authors.affiliation: Department of Molecular Pharmacology, Nagasaki University School of Pharmaceutical Sciences, 1-14 Bunkyo-machi, Nagasaki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Renbäck
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: F
authors.initials: F
authors.lastname: Nyberg
authors.forename: H
authors.initials: H
authors.lastname: Ueda
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D004155:Diphenhydramine / Q000494:pharmacology; D008246:Lysophospholipids / Q000494:pharmacology*; D008297:Male; D008407:Mast Cells / Q000378:metabolism; D051379:Mice; D020319:Oligodeoxyribonucleotides, Antisense / Q000494:pharmacology; D010146:Pain / Q000378:metabolism*; D010147:Pain Measurement; D037342:Pertussis Toxin; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; D010566:Virulence Factors, Bordetella / Q000494:pharmacology
chemical_list: D000779:Anesthetics, Local; D008246:Lysophospholipids; D020319:Oligodeoxyribonucleotides, Antisense; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; D010566:Virulence Factors, Bordetella; D004155:Diphenhydramine; D037342:Pertussis Toxin