[The effect of the duration of coronary occlusion on the healing of an experimental myocardial infarct].
Increasing the period of myocardial ischaemia prior to conduction of reperfusion adequality induces complicated healing of experimental myocardial infarction, thereby resulting in postinfarctional aneurysm of the heart. Complicated healing of myocardial infarction upon of coronary blood re-circulation after 3 or more hours of ischaemia, happens due to disbalance of necrotic and reparative processes in the infarct zone. Conduction of reperfusion induces activation of necrotic processes with retention and slowdown of reparative processes.
Syroïd
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DV
M. Gorky Medical University, Ministry of Public Health of Ukraine, Donetsk.
Sokrut
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VM
Shvyrenko
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IR
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003327:Coronary Disease / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D003402:Creatine Kinase / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D009203:Myocardial Infarction / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D009336:Necrosis; D013300:Streptokinase / Q000008:administration & dosage; D015912:Thrombolytic Therapy; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*
D005343:Fibrinolytic Agents; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D013300:Streptokinase