Complexity in the spindle checkpoint.
Cell viability requires accurate chromosome segregation at mitosis. The spindle checkpoint ensures that anaphase is not attempted until the sister chromatids of each chromosome are attached to spindle microtubules from opposite poles. The checkpoint mechanism involves a signal transduction cascade that is more complex than was originally envisioned.
Burke
D J
DJ
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22906, USA. dburke@virginia.edu.
D000818:Animals; D018797:Cell Cycle Proteins; D005656:Fungal Proteins / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000235:genetics / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D015003:Yeasts
C070351:BUB2 protein, S cerevisiae; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins