Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha.
Treatment with interferon-alpha (IFN-alpha) has been associated with the occurrence of a number of autoimmune disorders. We report a case of chronic inflammatory demyelinating polyneuropathy (CIDP) occurring in a patient with a chronic viral hepatitis C infection who received a novel, long-acting form of IFN-alpha. After withdrawal of the interferon treatment, this patient responded to a single extended course of plasma exchange that resulted in a complete clinical remission of symptoms without relapse.
Meriggioli
M N
MN
Section of Neuromuscular Disorders, Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA. mmeriggi@neuro.rush.edu
Rowin
J
J
D000328:Adult; D004185:Disability Evaluation; D018737:Hand Strength; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D008297:Male; D009431:Neural Conduction; D010951:Plasma Exchange; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology
D016898:Interferon-alpha