[Humoral immunity and antigens of HLA system in acute pancreatitis].
In the authors investigations patients with acute pancreatitis had antibodies to endogenic antigens: to o-DNA--in 58.5%, to d-DNA--in 53.7%, to n-DNA in 51.2%, to trypsin--in 42.7%, to insulin--in 28.1% and to the tissue antigen of the pancreas--in 19.5%. A rise of serum immunoglobulins' and circulating immune complexes' levels were established. Alterations of humoral immunity in connection with high frequency of antigens HLA A1, B8, B18 associated with disregulation among T- and B-links of immune system detected in patients with acute pancreatitis, represent genetic and humoral mechanisms which mediate the development of autoimmune reactions in this disease.
Trukhan
D I
DI
Poluéktov
V L
VL
D000208:Acute Disease; D000917:Antibody Formation / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D015415:Biomarkers; D004247:DNA / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000276:immunology; D008297:Male; D010195:Pancreatitis / Q000276:immunology*; D011379:Prognosis; D014357:Trypsin / Q000276:immunology
D015415:Biomarkers; D006680:HLA Antigens; D007328:Insulin; D004247:DNA; D014357:Trypsin