[The clinic significance of serum hyaluronate and tumor necrosis factor alpha levels in liver diseases].
Serum levels of hyaluronic acid (HA) and tumor necrosis factor alpha (TNF alpha) in 94 patients with various liver diseases and 31 healthy controls were studied by RIA, Serum TNF alpha in hepatitis, liver cirrhosis (LC) and primary hepatic carcinoma (PHC) was higher than that of the control. Serum HA in chronic hepatitis, LC and PHC was higher than that in the control. The serum level of HA showed a positive correlation with the serum level of TNF alpha. It is considered that the increase of serum HA indicates an early fibrogenic tendency in patients with liver diseases. TNF alpha is involved in the formation of hepatic fibrosis.
Zou
B
B
Department of Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha.
Ling
Q
Q
Huo
J
J
Lin
L
L
He
J
J
Pan
Y
Y
D006521:Hepatitis, Chronic / Q000097:blood*; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D008103:Liver Cirrhosis / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D006820:Hyaluronic Acid