Effect of crude extracts of Erythrina americana Mill. on aggressive behavior in rats.
Three alkaloid fractions were obtained from seeds of Erythrina americana: free alkaloids in hexane, free alkaloids in methanol and liberated alkaloids. The pharmacological evaluation of these fractions on rats showed that, administered in a dose of 3 mg/kg, the three fractions diminished the aggressive behavior. This is comparable when diazepam is used as a control. An interaction between the cholinergic and GABAergic system could be suggested.
Garín-Aguilar
M E
ME
ENEP-Iztacala, UNAM. Tlalnepantla, Edo. de Méx., Mexico.
Luna
J E
JE
Soto-Hernández
M
M
Valencia del Toro
G
G
Vázquez
M M
MM
D000374:Aggression / Q000187:drug effects*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003975:Diazepam / Q000494:pharmacology; D004895:Erythrina / Q000737:chemistry*; D007928:Lethal Dose 50; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D013997:Time Factors
D000470:Alkaloids; D010936:Plant Extracts; D003975:Diazepam