title: Randomised prospective parallel trial of therapeutic versus subtherapeutic nasal continuous positive airway pressure on simulated steering performance in patients with obstructive sleep apnoea.
abstract: BACKGROUND
  Obstructive sleep apnoea (OSA) impairs vigilance and may lead to an increased rate of driving accidents. In uncontrolled studies accident rates and simulated steering performance improve following treatment with nasal continuous positive airway pressure (NCPAP). This study seeks to confirm the improvement in steering performance in a randomised controlled trial using subtherapeutic NCPAP as a control treatment.
  
  
  METHODS
  Fifty nine men with OSA (Epworth Sleepiness Score (ESS) of > or =10, and > or =10/h dips in SaO(2) of >4% due to OSA) received therapeutic or subtherapeutic NCPAP ( approximately 1 cm H(2)O) for one month. Simulated steering performance over three 30-minute "drives" was quantified as: standard deviation (SD) of road position, deterioration in SD across the drive, length of drive before "crashing", and number of off-road events. The reaction times to peripheral target stimuli during the drive were also measured.
  
  
  RESULTS
  Subtherapeutic NCPAP did not improve overnight >4% SaO(2) dips/h compared with baseline values, thus acting as a control. The SD of the steering position improved from 0.36 to 0.21 on therapeutic NCPAP, and from 0.35 to 0.30 on subtherapeutic NCPAP (p = 0.03). Deterioration in SD of the steering position improved from 0.18 to 0.06 SD/h with therapeutic NCPAP and worsened from 0.18 to 0.24 with subtherapeutic NCPAP (p = 0.04). The reaction time to target stimuli was quicker after therapeutic than after subtherapeutic NCPAP (2.3 versus 2.7 seconds, p = 0.04).
  
  
  CONCLUSIONS
  Therapeutic NCPAP improves steering performance and reaction time to target stimuli in patients with OSA, lending further support to the hypothesis that OSA impairs driving, increases driving accident rates, and that these improve following treatment with NCPAP.
authors.affiliation: Osler Chest Unit, Churchill Campus, Oxford Radcliffe Trust, Oxford OX3 7LJ, UK.
authors.forename: M
authors.initials: M
authors.lastname: Hack
authors.forename: R J
authors.initials: RJ
authors.lastname: Davies
authors.forename: R
authors.initials: R
authors.lastname: Mullins
authors.forename: S J
authors.initials: SJ
authors.lastname: Choi
authors.forename: S
authors.initials: S
authors.lastname: Ramdassingh-Dow
authors.forename: C
authors.initials: C
authors.lastname: Jenkinson
authors.forename: J R
authors.initials: JR
authors.lastname: Stradling
mesh_terms: D000063:Accidents, Traffic / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D001334:Automobile Driving / Q000592:standards; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods*; D012891:Sleep Apnea Syndromes / Q000628:therapy*; D012893:Sleep Wake Disorders / Q000209:etiology