title: Review of fluoride research since 1959.
abstract: The evidence for the two main hypotheses proposed for the mode of action of F in reducing caries is reviewed. The current conclusion is that low concentrations of F in plaque, which need frequent renewal, favour remineralization of dental tissue (i.e. a net reduction of demineralization) in the later stages of a cariogenic episode. This replaces the other view that a high concentration of F in the tooth mineral reduces its solubility.
authors.forename: G N
authors.initials: GN
authors.lastname: Jenkins
mesh_terms: D003731:Dental Caries / Q000188:drug therapy*; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D012106:Research
chemical_list: D005459:Fluorides