title: Coexistence of several unbalanced translocations in a case of neuroblastoma: the contribution of multicolor spectral karyotyping.
abstract: Spectral karyotyping (SKY) is based on the simultaneous hybridization of a set of 24 chromosome-specific DNA painting probes, each labeled with a different fluor combination. Automatic classification, based on the measurement of the spectrum for each chromosome, was applied to metaphases obtained from the affected bone marrow of a neuroblastoma case. Spectral karyotyping allowed the identification of chromosomal aberrations that could not be identified by the use of the G-banding technique, and revealed a number of gains and unbalanced translocations.
authors.affiliation: Institute of Hematology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Trakhtenbrot
authors.forename: N
authors.initials: N
authors.lastname: Cohen
authors.forename: E
authors.initials: E
authors.lastname: Rosner
authors.forename: N
authors.initials: N
authors.lastname: Gipsh
authors.forename: F
authors.initials: F
authors.lastname: Brok-Simoni
authors.forename: M
authors.initials: M
authors.lastname: Mandel
authors.forename: N
authors.initials: N
authors.lastname: Amariglio
authors.forename: G
authors.initials: G
authors.lastname: Rechavi
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping / Q000379:methods*; D009447:Neuroblastoma / Q000235:genetics*; D014178:Translocation, Genetic