[Comparison of the effects of inhaled nitric oxide and intravasculare regitine on pulmonary gas exchange in young dogs with oleic-acid acute lung injury].
In order to find an agent which truly improves hypoxemia of some serious pediatric lung diseases, the authors examined the independent effects of nitric oxide inhalation and regitine infusion on blood gases, intrapulmonary shunt and hemodynamics in young dogs with oleic-acid acute lung injury. After nitric oxide inhalation, the results showed moderate increases in PaO2 and SaO2 (P > 0.05) and a significant decrease in Qs/Q tau ratio (P < 0.01). There was a significant decrease of PAP(P < 0.05), while SAP remained unchanged. After regitine infusion, however, there were marked decreases in PaO2 and SaO2 (P < 0.01); meanwhile, Qs/Q tau rose (P < 0.05). These suggest that with the presence of pulmonary pathology nitric oxide inhalation may alleviate the elevated pulmonary pressure without alteration in systemic artery pressure; so it can improve pulmonary ventilation-perfusion distribution and cause favorable changes in blood gases. On the other hand, regitine, as a non-selective vasodilator, reduces pulmonary artery pressure at the cost of significant worsening of blood oxygenation and systemic hypotension; so its routine use in childhood pulmonary diseases should be cautiously considered.
Xu
Y
Y
Second Affiliated Hospital, Chengdu.
Zhou
T
T
Hua
Y
Y
Wang
Z
Z
Jin
Z
Z
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007262:Infusions, Intravenous; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000494:pharmacology*; D019301:Oleic Acid; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000503:physiopathology*; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects
D000959:Antihypertensive Agents; D001993:Bronchodilator Agents; D019301:Oleic Acid; D009569:Nitric Oxide; D010646:Phentolamine