title: Effects of carnosine and related compounds on the stability and morphology of erythrocytes from alcoholics.
abstract: The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These beneficial properties of the dipeptides do not appear to be directly related to their antioxidant or buffering properties.
authors.affiliation: Mental Health Research Institute, Medical Academy of Sciences of Russia, Tomsk, Russia.
authors.forename: V D
authors.initials: VD
authors.lastname: Prokopieva
authors.forename: N A
authors.initials: NA
authors.lastname: Bohan
authors.forename: P
authors.initials: P
authors.lastname: Johnson
authors.forename: H
authors.initials: H
authors.lastname: Abe
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000097:blood* / Q000188:drug therapy; D017738:Alkanesulfonic Acids / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002021:Buffers; D002336:Carnosine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006461:Hemolysis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology
chemical_list: D017738:Alkanesulfonic Acids; D000897:Anti-Ulcer Agents; D002021:Buffers; D010879:Piperazines; C033681:N-acetylcarnosine; D002336:Carnosine; C008916:piperazine-N,N'-bis(2-ethanesulfonic acid)