title: Differential tumor surveillance by natural killer (NK) and NKT cells.
abstract: Natural tumor surveillance capabilities of the host were investigated in six different mouse tumor models where endogenous interleukin (IL)-12 does or does not dictate the efficiency of the innate immune response. Gene-targeted and lymphocyte subset-depleted mice were used to establish the relative importance of natural killer (NK) and NK1.1(+) T (NKT) cells in protection from tumor initiation and metastasis. In the models examined, CD3(-) NK cells were responsible for tumor rejection and protection from metastasis in models where control of major histocompatibility complex class I-deficient tumors was independent of IL-12. A protective role for NKT cells was only observed when tumor rejection required endogenous IL-12 activity. In particular, T cell receptor Jalpha281 gene-targeted mice confirmed a critical function for NKT cells in protection from spontaneous tumors initiated by the chemical carcinogen, methylcholanthrene. This is the first description of an antitumor function for NKT cells in the absence of exogenously administered potent stimulators such as IL-12 or alpha-galactosylceramide.
authors.affiliation: Cellular Cytotoxicity Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, 3084 Victoria, Australia. m.smyth@ari.unimelb.edu.au
authors.forename: M J
authors.initials: MJ
authors.lastname: Smyth
authors.forename: K Y
authors.initials: KY
authors.lastname: Thia
authors.forename: S E
authors.initials: SE
authors.lastname: Street
authors.forename: E
authors.initials: E
authors.lastname: Cretney
authors.forename: J A
authors.initials: JA
authors.lastname: Trapani
authors.forename: M
authors.initials: M
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Kawano
authors.forename: S B
authors.initials: SB
authors.lastname: Pelikan
authors.forename: N Y
authors.initials: NY
authors.lastname: Crowe
authors.forename: D I
authors.initials: DI
authors.lastname: Godfrey
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005260:Female; D005699:Galactosylceramides / Q000494:pharmacology; D019673:Genes, T-Cell Receptor alpha; D018664:Interleukin-12 / Q000494:pharmacology / Q000502:physiology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008099:Liver / Q000276:immunology; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014407:Tumor Cells, Cultured
chemical_list: D005699:Galactosylceramides; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D018664:Interleukin-12; D008748:Methylcholanthrene