Effect of rooperol on collagen synthesis and cell growth.
The effect of rooperol on type I collagen synthesis in normal skin and lung fibroblasts and cell growth in normal and transformed fibroblasts was investigated. Low concentrations of rooperol selectively inhibited the growth of transformed cells while stimulating collagen synthesis in normal fibroblasts. Elevated collagen synthesis and deposition could impede tumour cell invasion and metastasis, implying that rooperol may be useful as an antimetastatic agent in the treatment of cancer.
Dietzsch
E
E
Department of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Observatory, South Africa.
Albrecht
C F
CF
Parker
M I
MI
D002396:Catechols / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003094:Collagen / Q000096:biosynthesis*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism; D012867:Skin / Q000378:metabolism
D002396:Catechols; D016861:Cyclooxygenase Inhibitors; C079659:rooperol; D003094:Collagen