How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures.
In most cells, the structure of the actin cytoskeleton is regulated by Rho-family G proteins. Recent work has outlined a highly conserved signaling pathway from G protein activation to actin assembly. The key downstream components are WASP family proteins - adaptor molecules that bind multiple signaling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functional protein complex that nucleates and crosslinks actin filaments.
Mullins
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Department of Cellular and Molecular Pharmacology, University of California Medical School, San Francisco, CA 94129, USA. dyche@itsa. ucsf.edu
D008841:Actin Cytoskeleton / Q000737:chemistry / Q000378:metabolism; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001704:Biopolymers / Q000378:metabolism; D016764:Cell Polarity; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D051316:Wiskott-Aldrich Syndrome Protein; D020741:rho GTP-Binding Proteins / Q000378:metabolism
C495926:ACTR2 protein, human; C495928:ACTR3 protein, human; D051377:Actin-Related Protein 2; D051378:Actin-Related Protein 3; D000199:Actins; D001704:Biopolymers; D003598:Cytoskeletal Proteins; D011506:Proteins; C495767:WAS protein, human; D051316:Wiskott-Aldrich Syndrome Protein; D020741:rho GTP-Binding Proteins