Effect of immunization with synthetic peptide corresponding to region 1-17 of human seminal plasma inhibin on fertility of male rats.
Immunization of adult male rats with a synthetic peptide corresponding to the region 1-17 of human seminal plasma inhibin (hSPI) resulted in agglutination of epididymal sperm, severely affecting the fertility of the animals (75% reduction in fertility as compared to control). This effect was found to be dependent on the antibody titer to hSPI. There was a significant rise in circulating follicle-stimulating hormone levels, with luteinizing hormone and testosterone levels remaining unaffected. The histology of the testes and other reproductive organs revealed that these organs remained unaltered. The N-terminal 1-17 amino acid peptide of hSPI may hold promise as an immunogen for male immunocontraception.
Vanage
G R
GR
Institute for Research in Reproduction, Mumbai, India.
Mehta
P B
PB
Moodbidri
S B
SB
Iyer
K S
KS
D000818:Animals; D000906:Antibodies / Q000097:blood; D003269:Contraception, Immunologic; D005260:Female; D005298:Fertility / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007265:Inhibins / Q000276:immunology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D010446:Peptide Fragments / Q000276:immunology*; D011247:Pregnancy; D051381:Rats; D012661:Semen / Q000276:immunology*; D013073:Sperm Agglutination / Q000276:immunology; D013076:Sperm Count; D013737:Testis / Q000033:anatomy & histology; D013739:Testosterone / Q000097:blood; D014611:Vaccination
D000906:Antibodies; D010446:Peptide Fragments; D013739:Testosterone; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone