title: [Effects of overdose fluoride on metabolism of extracellular matrix collagen and proteoglycan in condylar cartilage].
abstract: The study was conducted to evaluate the effects of chronic fluorosis on the metabolism of extracellular matrix in the development of rabbit condylar cartilage using the technique of pathology, biochemistry and radiographs. The results demonstrated that collagen content of condylar cartilage and the bone under condylar cartilage decreased (P < 0.01), and the proteoglycar contents increased significantly during the process of fluorosis (P < 0.01). The chondroprogenitor was obviously thin, and the cells of maturation zone increased in number. All the results indicated that overdose of fluoride retarded the growth of the condyle and ramus of the mandible.
authors.affiliation: School of Stomatology, Norman Bethune University of Medical Sciences, Changchun.
authors.forename: X
authors.initials: X
authors.lastname: Ni
authors.forename: J
authors.initials: J
authors.lastname: Cai
authors.forename: L
authors.initials: L
authors.lastname: Hou
mesh_terms: D000818:Animals; D002356:Cartilage / Q000378:metabolism / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism* / Q000473:pathology; D005260:Female; D009050:Fluorosis, Dental / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008335:Mandibular Condyle / Q000378:metabolism / Q000473:pathology; D011509:Proteoglycans / Q000378:metabolism*; D011817:Rabbits
chemical_list: D011509:Proteoglycans; D003094:Collagen