title: [The second phase clinical observation of anti-radiation effect by superoxide dismutase].
abstract: Multiple center randomized controlled double blind clinical trait was conducted to evaluate the anti-radiotherapy effect by SOD (produced by Hunan Biochemical Work) in 159 patients. Injection of 4000U SOD immediately after receiving radiotherapy significantly reduced the occurrence rate of skin, oral mucosal, pelvic visceral and systematic adverse reaction, only the reduction of leukopenia did not reach the statistical significant level. No adverse effect of SOD injection was observed. The results suggest that SOD is a safe and effective agent to attenuate the radiotherapy reactions.
authors.affiliation: Xiangya Hospital, Hunan Medical University, Changsha.
authors.forename: Q
authors.initials: Q
authors.lastname: Tu
authors.forename: J
authors.initials: J
authors.lastname: Tang
authors.forename: L
authors.initials: L
authors.lastname: Shen
authors.forename: Y
authors.initials: Y
authors.lastname: Lei
authors.forename: S
authors.initials: S
authors.lastname: Yu
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: J
authors.initials: J
authors.lastname: He
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.forename: F
authors.initials: F
authors.lastname: Dong
authors.forename: H
authors.initials: H
authors.lastname: Peng
authors.forename: H
authors.initials: H
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011882:Radiotherapy, High-Energy; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D014839:Vomiting / Q000188:drug therapy / Q000209:etiology
chemical_list: D011837:Radiation-Protective Agents; D013482:Superoxide Dismutase