title: Elevated serum transforming growth factor beta1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM.
abstract: Transforming growth factor beta (TGF-beta) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-beta in various EBV-associated diseases correlating positively with EBV-specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.
authors.affiliation: Laboratory of Immunovirology, Pediatric Research Center and Department of Microbiology & Immunology, University of Montreal and Sainte-Justine Hospital, Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: A
authors.initials: A
authors.lastname: Ahmad
authors.forename: J F
authors.initials: JF
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Dolcetti
authors.forename: E
authors.initials: E
authors.lastname: Vaccher
authors.forename: U
authors.initials: U
authors.lastname: Prasad
authors.forename: J
authors.initials: J
authors.lastname: Menezes
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D020031:Epstein-Barr Virus Infections / Q000097:blood* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D012044:Regression Analysis; D016212:Transforming Growth Factor beta / Q000097:blood*
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D016212:Transforming Growth Factor beta