Possible analgesic effect of vigabatrin in animal experimental chronic neuropathic pain.
Since anticonvulsants have been used for treating neuralgias, an interest has arisen to experimentally test vigabatrin for its gabaergic mechanism of action. For this, 41 Wistar rats were used, and in 25 of them a constrictive sciatic neuropathy was induced (Bennet & Xie model). For testing pain symptoms, spontaneous (scratching) and evoked behaviors to noxious (46 degrees C) and non-noxious (40 degrees C) thermal stimuli were quantified. Moreover, a comparative pharmacological study of vigabatrin with other analgesic anticonvulsant drugs was also performed. The results showed a possible dose-dependent analgesic effect of vigabatrin (gamma-vinyl-GABA) on experimental neuropathic pain, as shown by the significant (p < 0.05) decreasing effect of vigabatrin on scratching and by its significant (p < 0.05) increasing effect on the latency of the right hindpaw withdrawal of the animals to noxious thermal stimulus. This was corroborated by similar findings with analgesic anticonvulsants (carbamazepine, phenytoin and valproic acid). This possible and not yet described analgesic effect of vigabatrin seems not to be opioid mediated.
Alves
N D
ND
Laboratory of Experimental Neurology (Department of Physiology and Pharmacology), Federal University of Ceará (UFC), Brazil.
de Castro-Costa
C M
CM
de Carvalho
A M
AM
Santos
F J
FJ
Silveira
D G
DG
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D002908:Chronic Disease; D009437:Neuralgia / Q000188:drug therapy*; D010672:Phenytoin / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000627:therapeutic use; D020888:Vigabatrin / Q000627:therapeutic use*
D000700:Analgesics; D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D020888:Vigabatrin