[Effects of high dietary zinc on liver function, hepatic drug metabolism enzymes and membrane fluidity in mice].
Mice were fed with high zinc diet (15 g/kg) for 3 weeks. High zinc could cause liver toxicity: 1. inhibiting the activity of GOT and GPT in liver homogenate, reducing GSH and glycogen contents. 2. increasing the activity of aniline hydroxylase and inhibiting the activities of NADPH-cytochrome C reducease, benzo-phytamine-N-demethylase and glutathione S-transferase. The activities of cytochrome P450 and cytochrome b5 were not obviously changed 3. increasing microsomal membrane fluidity in the superficial layers, but not in the deep layers.
Ding
H
H
Department of Pharmacology, Hubei Medical University, Wuhan, China.
Peng
R
R
Chen
J
J
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000502:physiology*; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D009245:NADH Dehydrogenase / Q000378:metabolism; D015032:Zinc / Q000494:pharmacology*
D009245:NADH Dehydrogenase; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D015032:Zinc