In vitro senescence models for human T lymphocytes.
Immunosenescence is an age-associated dysregulation of immune function which may contribute to the increased susceptibility of the elderly to infectious disease. Although age-associated changes are measurable in the innate immune system, it is the adaptive arm of the immune system which is particularly susceptible to the deleterious effects of ageing, especially the T cell compartment. In this review, the characteristics of longitudinal ageing in cultured monoclonal human T cell populations will be summarized. It will be argued that parallels between this in vitro model and T cell senescence in vivo suggest the use of such models to screen for interventions ameliorating immunosenescence in vivo.
Pawelec
G
G
Tübingen Ageing and Tumour Immunology (TATI) Group, Second Department of Internal Medicine, Medizinische Universitätsklinik und Poliklinik, Otfried-Müller-Str. 10, D-72076, Tübingen, Germany. graham.pawalec@uni-tuebingen.de
Adibzadeh
M
M
Rehbein
A
A
Hähnel
K
K
Wagner
W
W
Engel
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D015703:Antigens, CD / Q000378:metabolism; D017209:Apoptosis; D015415:Biomarkers / Q000032:analysis; D002455:Cell Division; D016922:Cellular Senescence / Q000276:immunology*; D002999:Clone Cells; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008938:Mitosis; D008954:Models, Biological; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology / Q000276:immunology*; D019098:Telomerase / Q000378:metabolism
D015703:Antigens, CD; D015415:Biomarkers; D016207:Cytokines; D019098:Telomerase