Periventricular white matter hyperintensities on MRI: correlation with neuropathologic findings.
Periventricular white matter hyperintensities on postmortem magnetic resonance imaging (MRI) and myelin-stained frontal and parietal histologic sections were evaluated independently in 12 cases. There was a strong relationship between the extent of white matter hyperintensities on MRI and the extent of gross and microscopic changes seen in the white matter of myelin-stained sections, particularly in the frontal lobe. In this material, the extent of myelin rarefaction correlated with a 0- to 8-point white matter hyperintensity scale rating on MRI in the same brains.
Smith
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Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington 40536, USA.
Snowdon
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Markesbery
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D000375:Aging / Q000473:pathology; D001921:Brain / Q000473:pathology*; D002102:Cadaver; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018709:Statistics, Nonparametric