title: Comparative analysis of left ventricular hemodynamics and hypertrophy after aortic valve replacement with homografts or mechanical valves.
abstract: OBJECTIVE
  The study aim was to examine comparatively the effects of prosthetic and homograft valves in the aortic position on ventricular hemodynamics and structure.
  
  
  METHODS
  Hemodynamic evaluations were performed at rest and during exercise in 38 patients who had undergone aortic valve replacement (AVR) with either a homograft (n = 19) or prosthetic valve (19-23 mm; n = 19). Using echocardiographic, electrocardiographic and hematologic methods, the pressure gradient (PG); aortic valve area; diameters of left anterior wall, posterior wall (PW) and interventricular septum (IVS); ejection fraction (EF); left ventricular mass (LVM) and mass index (LVMI); electrocardiographic data of LV hypertrophy; hemoglobin; hematocrit and lactate dehydrogenase (LDH) levels were measured.
  
  
  RESULTS
  LVM and LVMI decreased significantly after surgery in both groups (p<0.001), but the decrease was significantly greater in the homograft group (p<0.05). The IVS and PW diameters in the homograft group decreased significantly postoperatively (p<0.05); the inter-group difference was also significant (p<0.01). In the homograft group there was a significant improvement in EF (p<0.05), and the exercise PG was significantly less. Both groups showed improved LV hypertrophy and correlation between V1S >24 mm criteria and LVMI measurements. Postoperative LDH levels in the homograft group were significantly lower than preoperative levels (p<0.05); the intergroup difference was also significant (p<0.001).
  
  
  CONCLUSIONS
  Our data suggest that homografts, as compared to mechanical prostheses, provide significantly better hemodynamics in the aortic position.
authors.affiliation: Department of Cardiovascular Surgery, Ege University Medical Faculty, Izmir, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Basarir
authors.forename: F
authors.initials: F
authors.lastname: Islamoglu
authors.forename: E
authors.initials: E
authors.lastname: Ozkisacik
authors.forename: Y
authors.initials: Y
authors.lastname: Atay
authors.forename: M
authors.initials: M
authors.lastname: Boga
authors.forename: T
authors.initials: T
authors.lastname: Bakalim
authors.forename: M
authors.initials: M
authors.lastname: Ozbaran
authors.forename: A
authors.initials: A
authors.lastname: Telli
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery* / Q000637:transplantation; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D002648:Child; D005260:Female; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D007223:Infant; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous; D016277:Ventricular Function, Left