Incidence and significance of profound hypotension during dobutamine stress echocardiography.
BACKGROUND
Mild hypotension (drops of systolic blood pressure of > or = 20 mmHg) occurs in 14-38% of dobutamine stress echo (DSE) and carries a good prognosis for subsequent cardiac events. The incidence and significance of more profound hypotension (PH) (> or = 50 mmHg) is unknown.


OBJECTIVE
The aim of the study was to determine the incidence of PH during DSE and its prognosis for subsequent cardiac events.


METHODS
We reviewed 617 DSE performed at our institution between 1992 and 1996 and identified two DSE subgroups. The first group (PH group) consisted of all patients with PH during DSE. A second group was selected with baseline characteristics similar to the PH group but without PH during DSE (non-PH group). Follow-up was by a physician chart review and direct telephone contact. Cardiac event rates were determined for hard [myocardial infarction (MI), or cardiac death] and soft (angina, congestive heart failure, coronary angioplasty, or coronary bypass surgery) events occurring after the DSE.


RESULTS
Of the 617 DSE performed, 16 (3%) patients developed PH (PH group) during DSE, with 13 showing no inducible ischemia. The hard and soft cardiac event rate in this 13 PH group was 46% (mean follow-up of 28.7 +/- 18 months). Of the non-PH group, 32 patients had a negative DSE with a coronary event rate of 12.5%. Profound hypotension correlated with a significantly higher cardiac event rate (p < 0.02).


CONCLUSIONS
The incidence of PH during DSE is low (3%) and appears to predict a worse prognosis for subsequent cardiac events.
Dhond
M R
MR
Division of Cardiovascular Medicine, University of California Davis Medical Center, Sacramento 95817, USA.
Whitley
T B
TB
Singh
S
S
Nguyen
T T
TT
Bommer
W J
WJ
D002140:California / Q000453:epidemiology; D002316:Cardiotonic Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging* / Q000401:mortality / Q000503:physiopathology; D004280:Dobutamine / Q000009:adverse effects*; D004452:Echocardiography / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D015994:Incidence; D008297:Male; D008499:Medical Records; D009203:Myocardial Infarction / Q000209:etiology; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D015996:Survival Rate
D002316:Cardiotonic Agents; D004280:Dobutamine