title: [Additional effects of statins independent of the cholesterol-lowering as yet not shown to be clinically relevant].
abstract: The reduction in cardiovascular morbidity and mortality during the use of statins is due to their cholesterol lowering effect. In addition, the statins are assumed to exert lipid lowering independent actions, which may contribute to the beneficial effect. However, the evidence for these effects is based on less solid sub- and post hoc analyses of clinical trials and in vitro and animal experiments in which unrealistic doses of statins are used. On closer examination, most of these so-called lipid independent effects are in fact based on either direct or indirect cholesterol lowering. The clinical relevance has to be shown in prospective clinical trials.
authors.affiliation: Academisch Ziekenhuis St.-Radboud, afd. Algemene Interne Geneeskunde, Nijmegen.
authors.forename: A F
authors.initials: AF
authors.lastname: Stalenhoef
authors.forename: C D
authors.initials: CD
authors.lastname: Stehouwer
mesh_terms: D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D015986:Confounding Factors, Epidemiologic; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D007211:Indoles / Q000494:pharmacology; D008148:Lovastatin / Q000494:pharmacology; D017035:Pravastatin / Q000494:pharmacology; D019821:Simvastatin / Q000494:pharmacology
chemical_list: D000924:Anticholesteremic Agents; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin; D008148:Lovastatin; D019821:Simvastatin; D017035:Pravastatin