[Main causes of hyperuricemia in diabetes mellitus].
OBJECTIVE
Investigation of hyperuricemia (HU) causes in diabetes mellitus (DM).


METHODS
Purin, lipid and carbohydrate metabolisms, renal excretion of uric acid (UA) were examined in 535 patients with DM. Non-insulin-dependent DM (NIDDM) and insulin-dependent DM (IDDM) were diagnosed in 369 and 166 patients, respectively.


RESULTS
Hyperglycemia and glucosuria in DM enhance renal excretion of UA. However, HU in DM occurs significantly more frequently than in the population (22.5 +/- 3.0% in IDDM and 29.9 +/- 2.5% of cases in NIDDM).


CONCLUSIONS
In NIDDM, HU genesis is strongly related with renal lesions. In IDDM, HU genesis is associated with metabolic factors (high activity of xantinoxidase, lipid peroxidation, obesity). However, combination of factors is, as a rule, involved in HU development: renal dysfunction and hyperproduction of UA.
Madianov
I V
IV
Balabolkin
M I
MI
Markov
D S
DS
Markova
T N
TN
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000652:urine; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000652:urine; D006029:Glycosuria / Q000652:urine; D006801:Humans; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood* / Q000652:urine
D015415:Biomarkers; D001786:Blood Glucose; D014527:Uric Acid