title: Risk of female breast cancer associated with serum polychlorinated biphenyls and 1,1-dichloro-2,2'-bis(p-chlorophenyl)ethylene.
abstract: This case-control study was designed to investigate the relationship between polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2'-bis(p-chlorophenyl)ethylene (DDE) and breast cancer risk in Connecticut. Cases were incident breast cancer patients who were either residents of Tolland County or who had a breast-related surgery at the Yale-New Haven Hospital in New Haven County. Controls were randomly selected from Tolland County residents or from patients who had newly diagnosed benign breast diseases or normal tissue at Yale-New Haven Hospital. A total of 475 cases and 502 controls had their serum samples analyzed for PCBs and DDE in 1995-1997. The age- and lipid-adjusted geometric mean serum level of DDE was comparable between the cases (460.1 ppb) and controls (456.2 ppb). The geometric mean serum level of PCBs was also comparable between cases (733.1 ppb) and controls (747.6 ppb). After adjustment for confounding factors, odds ratios of 0.96 (95% confidence interval, 0.67-1.36) for DDE and 0.95 (95% confidence interval, 0.68-1.32) for PCBs were observed when the third tertile was compared with the lowest. Further stratification by parity, lactation, and menopausal and estrogen receptor status also showed no significant association with serum levels of DDE or PCBs. The results by PCB congener groups also showed no major increased risk associated with any of the congener groups. Our study does not support the hypothesis that DDE and PCBs, as encountered through environmental exposure, increase the risk of female breast cancer.
authors.affiliation: Yale University School of Medicine and Yale Cancer Center, New Haven, Connecticut 06520, USA. tongzhang.zheng@yale.edu
authors.forename: T
authors.initials: T
authors.lastname: Zheng
authors.forename: T R
authors.initials: TR
authors.lastname: Holford
authors.forename: S T
authors.initials: ST
authors.lastname: Mayne
authors.forename: J
authors.initials: J
authors.lastname: Tessari
authors.forename: B
authors.initials: B
authors.lastname: Ward
authors.forename: D
authors.initials: D
authors.lastname: Carter
authors.forename: P H
authors.initials: PH
authors.lastname: Owens
authors.forename: P
authors.initials: P
authors.lastname: Boyle
authors.forename: R
authors.initials: R
authors.lastname: Dubrow
authors.forename: S
authors.initials: S
authors.lastname: Archibeque-Engle
authors.forename: O
authors.initials: O
authors.lastname: Dawood
authors.forename: S H
authors.initials: SH
authors.lastname: Zahm
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016022:Case-Control Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000009:adverse effects* / Q000097:blood; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D007306:Insecticides / Q000009:adverse effects* / Q000097:blood; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000009:adverse effects* / Q000097:blood; D011960:Receptors, Estrogen / Q000032:analysis; D012307:Risk Factors
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D011960:Receptors, Estrogen; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls