Synthesis of a polymeric 4-N-linked sialoside which inhibits influenza virus hemagglutinin.
A multiple sialic acid-bearing polymer 7 has been made in which a novel 4-N-substituted sialoside 5 has been coupled to polyacrylamide. The conjugate 7 has been found to inhibit the agglutination of influenza virus to red blood cells with HAI inhibition constants of around 10(-6) M, based on the sialic acid concentration.
Wu
W Y
WY
Chemistry Department, Monash University, Clayton, Victoria, Australia.
Jin
B
B
Krippner
G Y
GY
Watson
K G
KG
D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002645:Chickens / Q000097:blood; D004912:Erythrocytes / Q000473:pathology; D006389:Hemagglutinins, Viral / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009975:Orthomyxoviridae / Q000737:chemistry*; D012794:Sialic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014764:Viral Proteins / Q000187:drug effects
D000180:Acrylic Resins; D006389:Hemagglutinins, Viral; D012794:Sialic Acids; D014764:Viral Proteins