How are antibodies involved in the protective mechanism of susceptible mice infected with T. cruzi?
Host resistance to Trypanosoma cruzi is dependent on both natural and acquired immune responses. During the acute phase of the infection the presence of IFN-gamma, TNF-alpha, IL-12 and GM-CSF has been closely associated with resistance, whereas TGF-ss and IL-10 have been associated with susceptibility. Several investigators have demonstrated that antibodies are responsible for the survival of susceptible animals in the initial phase of infection and for the maintenance of low levels of parasitemia in the chronic phase. However, how this occurs is not yet understood. Our results and other data in the literature support the hypothesis that the protective role of antibodies in the acute phase of infection is dependent mostly on their ability to induce removal of bloodstream trypomastigotes from the circulation in addition to other concomitant cell-mediated events.
Umekita
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LF
Laboratório de Imunopatologia, Instituto Butantan, São Paulo, SP, Brasil. umekita@amcham.com.br
Mota
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I
D000818:Animals; D000913:Antibodies, Protozoan / Q000502:physiology*; D014355:Chagas Disease / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D004198:Disease Susceptibility; D051379:Mice; D014349:Trypanosoma cruzi / Q000276:immunology*
D000913:Antibodies, Protozoan; D016207:Cytokines