title: Determination of tungsten in bulk drug substance and intermediates by ICP-AES and ICP-MS.
abstract: A quick and sensitive method has been developed and validated for the determination of tungsten in bulk drug substance and intermediates using either Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sample preparation is by direct dissolution with a 80:20 (v/v) concentrated nitric acid:deionized water mixture and avoids labor intensive and potentially hazardous digestion techniques. Excellent agreement was found between ICP-AES and ICP-MS results and between Merck results and Microwave Induced Plasma Mass Spectrometry (MIP-MS) results provided by an independent raw material vendor.
authors.affiliation: Analytical Research Department, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Ge
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: B
authors.initials: B
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Liang
mesh_terms: D013058:Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011786:Quality Control; D012015:Reference Standards; D015203:Reproducibility of Results; D013052:Spectrometry, X-Ray Emission / Q000379:methods*; D014414:Tungsten / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D014414:Tungsten