title: Control of spatial patterning and cell-type proportioning in Dictyostelium.
abstract: The spatial patterning of prestalk and prespore cells in the slug arises from the differential sorting of newly differentiated cell types as the mound forms. This pattern is highly organized along an anterior-posterior axis and is constant irrespective of the size of the organism. Cell-type differentiation is plastic until late in development. A change in the ratio of cell types resulting from removal of part of the slug leads to a rapid restoration of the original ratio of the cell types through a pathway involving dedifferentiation, redifferentiation, and sorting of the existing cells. This review provides insight into various molecules, morphogens, and pathways regulating spatial patterning and cell-type proportioning.
authors.affiliation: Department of Biology, Center for Molecular Genetics, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0634, USA.
authors.forename: S
authors.initials: S
authors.lastname: Mohanty
authors.forename: R A
authors.initials: RA
authors.lastname: Firtel
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology; D004023:Dictyostelium / Q000166:cytology* / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology