Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test.
CD. However, the pattern of responding at DRL-60s suggested poor schedule control for the WKY rats. Therefore, the performance of SHR in the DRL test does not appear to represent a valid model of ADHD. Further, our findings with the WKY rat suggest that this strain is a poor behavioural control for the SHR.
Bull
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E
Neuroscience Research, SmithKline Beecham Pharmaceuticals plc, New Frontiers Science Park, Harlow, Essex, UK.
Reavill
C
C
Hagan
J J
JJ
Overend
P
P
Jones
D N
DN
D000818:Animals; D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics / Q000503:physiopathology*; D001921:Brain / Q000502:physiology; D004195:Disease Models, Animal; D005838:Genotype; D007175:Impulsive Behavior / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009042:Motivation; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012055:Reinforcement Schedule; D013045:Species Specificity