Total and local changes in the arthritis adjuvans.
Arthritis adjuvans was studied in the murine model. An effect of different treatment (methotrexate, tauredon, collagen hydrolysate) was estimated in the course of developing disease (day 3, 5, 11 and 21). Repeated evaluation of body weight and peripheral blood leukograms as a total response of organism was performed. Oedema of paw periarticular and tail regions, light- and electron-microscopical screening and immunohistochemical investigation of prevalence of interleukin-1-beta (IL-1beta) and tumour necrosis factor (TNF-alpha) were estimated. The most pronounced benefit effect of methotrexate at stabilization of the monocytes blood level, synovial membrane cell invasion and TNF-alpha immunopositivity was ascertained.
Martínek
J
J
Department of Histology and Embryology, 1st Medical Faculty, Charles University, Prague, Czech Republic. jmart@lf1.cuni.cz
Hulejová
H
H
Adam
M
M
D000818:Animals; D018501:Antirheumatic Agents / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D007375:Interleukin-1 / Q000378:metabolism; D008727:Methotrexate / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects; D051381:Rats; D011917:Rats, Inbred Lew; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D018501:Antirheumatic Agents; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D006052:Gold Sodium Thiomalate; D003094:Collagen; D008727:Methotrexate