[Chronic hepatitis: indicators of disease activity].
OBJECTIVE
To assess correlations between activity of chronic hepatitis (CH) by morphological data on the liver and alaninaminotransferase (AlAT) serum levels in patients with viral and alcoholic liver lesions.


METHODS
Serological, biochemical blood tests and histology of hepatic biopsy were made in 47 patients with chronic hepatitis.


RESULTS
The Knodell index characterizing the activity of chronic hepatitis by morphological evidence correlated with AlAT activity in the serum. Normal values may be associated with 1 to 5 scores by the Knodell index. AsAT/AlAT was higher in patients with CH free of virus markers.


CONCLUSIONS
Morphological data (Knodell's index), AlAT activity and AsAT/AlAT indicate CH activity. AsAT/AlAT may help in elucidation of the presence or absence of alcohol abuse.
Masevich
Ts G
TsG
Ermolaeva
L G
LG
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006508:Hepatitis Antibodies / Q000032:analysis*; D006518:Hepatitis Viruses / Q000276:immunology; D006519:Hepatitis, Alcoholic / Q000175:diagnosis* / Q000201:enzymology; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000201:enzymology / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
D015415:Biomarkers; D006508:Hepatitis Antibodies; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase