title: Successful non-surgical treatment of Candida tropicalis endocarditis with liposomal amphotericin-B (AmBisome).
abstract: Fungal endocarditis in children is most commonly a complication of palliative or curative surgery for congenital heart disease, rheumatic valvulitis and prolonged indwelling central venous and umbilical catheters. We describe here the case of a 3-y-old patient with chronic diarrhoea and prolonged total parenteral alimentation who developed severe C. tropicalis endocarditis and was treated successfully using a liposomal preparation of amphotericin-B (AmBisome) without surgical intervention.
authors.affiliation: Pediatric Infectious Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Melamed
authors.forename: E
authors.initials: E
authors.lastname: Leibovitz
authors.forename: O
authors.initials: O
authors.lastname: Abramson
authors.forename: A
authors.initials: A
authors.lastname: Levitas
authors.forename: N
authors.initials: N
authors.lastname: Zucker
authors.forename: R
authors.initials: R
authors.lastname: Gorodisher
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy*; D002675:Child, Preschool; D002908:Chronic Disease; D003967:Diarrhea / Q000150:complications; D004337:Drug Carriers; D004452:Echocardiography; D004696:Endocarditis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D008081:Liposomes; D008297:Male; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B