Molecular forms of alpha-melanocyte-stimulating hormone in pheochromocytoma tissue.
The molecular forms of alpha-melanocyte-stimulating hormone (MSH) in pheochromocytoma tissues have been characterized using reversed-phase HPLC and radioimmunoassay. Six alpha-MSH-related peptides were detected. Three of the six peaks had elution times identical to those of synthetic desacetyl-alpha-MSH, alpha-MSH and diacetyl-alpha-MSH. The remaining three forms of the alpha-MSH-like immunoreactivity suggest a different processing of pro-opiomelanocortin in this tissue than in the intermediate lobe of the pituitary gland. Current results confirm that alpha-MSH are present in human pheochromocytoma and suggest that alpha-MSH has role in the pathophysiology of this tissue.
Gardi
J
J
Endocrine Unit, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Khalil
W K
WK
Vecsernyés
M
M
Gáspár
L
L
Szécsi
M
M
Julesz
J
J
D000310:Adrenal Gland Neoplasms / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism; D010673:Pheochromocytoma / Q000378:metabolism*; D011863:Radioimmunoassay; D000521:alpha-MSH / Q000737:chemistry* / Q000378:metabolism*
D010446:Peptide Fragments; D000521:alpha-MSH