title: Radical scavenging properties of tryptophan metabolites. Estimation of their radical reactivity.
abstract: Radical scavenging properties of tryptophan metabolites were estimated using their radical reactivity. Metabolites of the kynurenine and the melatonin biosynthesis pathway were mainly examined by use of a kinetical model. Their radical reactivity was determined as the reaction rate constant with a stable free radical, such as galvinoxyl; that is a phenoxy radical. The rate constants of the metabolites have a widely ranged spectrum, which can be divided into three groups. The first group (3-hydroxykynurenine, 3-hydroxyanthranilic acid, and indole-3-pyruvic acid) is more reactive than alpha-tocopherol; the reactivity of the second group (xanthurenic acid, serotonin, N-acetylserotonin) is similar to that of butylated hydroxytoluene (BHT); the third group (kynurenic acid, melatonin, and other ones) is less reactive than BHT.
authors.affiliation: Faculty of Nutrition, Kobe Gakuin University, Japan. goda@nutr.kobegakuin.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Goda
authors.forename: Y
authors.initials: Y
authors.lastname: Hamane
authors.forename: R
authors.initials: R
authors.lastname: Kishimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ogishi
mesh_terms: D016166:Free Radical Scavengers / Q000737:chemistry*; D005609:Free Radicals; D007211:Indoles / Q000737:chemistry*; D007700:Kinetics; D007736:Kynurenic Acid / Q000737:chemistry; D015227:Lipid Peroxidation; D008956:Models, Chemical; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000737:chemistry*; D014977:Xanthurenates / Q000737:chemistry
chemical_list: D016166:Free Radical Scavengers; D005609:Free Radicals; D007211:Indoles; D014977:Xanthurenates; C028330:xanthurenic acid; D014364:Tryptophan; D007736:Kynurenic Acid