title: Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography.
abstract: We compared regional cerebral blood flow (rCBF) in 15 patients with DSM IIIR obsessive-compulsive disorder (OCD), 15 patients with DSM IIIR panic disorder and 15 healthy controls matched for age, sex and hand preference, using uptake of technetium-99m-D,L-hexamethyl-propylene amine oxime (99mTc HMPAO), on single photon emission computerised tomography (SPECT). Caudate rCBF was significantly reduced in OCD patients compared to healthy subjects and panic disorder patients. When four patients were excluded from each group, right caudate rCBF remained significantly lower in OCD patients than in panic disorder patients or healthy subjects. The data suggest functional involvement of the right caudate nucleus is present in OCD.
authors.affiliation: Department of Psychological Medicine, St. Bartholomew's and The Royal London School of Medicine and Dentistry, West Smithfield, UK. j.v.lucey@mds.qmw.ac.uk
authors.forename: J V
authors.initials: JV
authors.lastname: Lucey
authors.forename: D C
authors.initials: DC
authors.lastname: Costa
authors.forename: G
authors.initials: G
authors.lastname: Busatto
authors.forename: L S
authors.initials: LS
authors.lastname: Pilowsky
authors.forename: I M
authors.initials: IM
authors.lastname: Marks
authors.forename: P J
authors.initials: PJ
authors.lastname: Ell
authors.forename: R W
authors.initials: RW
authors.lastname: Kerwin
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000098:blood supply* / Q000000981:diagnostic imaging; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging* / Q000503:physiopathology; D016584:Panic Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019690:Technetium Tc 99m Exametazime