[Cytokines in the treatment and prevention of postoperative infectious complications in patients with colorectal cancer].
Surgery for colorectal carcinoma has supplemented the following cytokine-based procedures: (1) extracorporeal immunotherapy (EIT) with autologous rIL2-activated mononuclear cells for treatment of patients with infectious complications, and (2) extracorporeal infusion immunotherapy with native cytokines (perfusate of xenospleen) to prevent postoperative infectious complications. EIT was followed by an effective correction of T-cell immunodeficiency and rehabilitation of monocytic function; rapid decrease in symptoms of endotoxicity; improved response to conventional therapy, and, as a result, a fall in mortality rates (from 38.9 to 11.7%). Immunotherapy with native cytokines brought about a significant decrease in postoperative complication incidence (36.4-15.8%), the average length of stay in hospital falling by 6.8 days. Immunological correction with cytokines was instrumental in raising the efficacy of surgical treatment of colorectal tumors.
Ostanin
A A
AA
Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk.
Pal'tsev
A V
AV
Shalganova
I G
IG
Leplina
O Iu
OIu
Shevela
E Ia
EIa
Chernykh
E R
ER
D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery*; D016207:Cytokines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007239:Infections / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D016019:Survival Analysis; D016896:Treatment Outcome
D016207:Cytokines; D011994:Recombinant Proteins