title: Otoacoustic emissions and auditory brainstem responses after neonatal hyperbilirubinemia.
abstract: Severe hyperbilirubinemia often results in hearing loss. Behavioral audiometry, auditory-evoked brainstem responses (ABRs) and otoacoustic emissions (OAEs) were performed in three such patients in an attempt to localize the pathophysiology of this hearing loss. Behavioral audiometric findings in these patients (all male, 4, 15 and 25 years old) ranged from severe in the 4-year-old, moderate in the 15-year-old and slight in the 25-year-old. Where obtained, ABR wave V thresholds were elevated or ABR were absent. However, absolute and inter-wave latency measurements were not indicative of brainstem pathology. OAEs (transient and distortion product) could only be obtained in the high- or low-frequency ranges in these patients. Our findings suggest that at least some lesions producing hearing loss in severe hyperbilirubinemia are in the cochlea, especially at the outer hair cells. Finally, we found that only moderately elevated serum bilirubin levels (<20 mg/dl) may contribute to the development of sensorineural hearing loss.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. kianoush@m.u-tokyo.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Sheykholeslami
authors.forename: K
authors.initials: K
authors.lastname: Kaga
mesh_terms: D000293:Adolescent; D000328:Adult; D001299:Audiometry / Q000379:methods; D001307:Auditory Perception / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem; D006311:Hearing Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications* / Q000175:diagnosis; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous; D012680:Sensitivity and Specificity