Disparate requirement for T cells in resistance to mucosal and acute systemic candidiasis.
Although highly susceptible to orogastric candidiasis, T-cell receptor delta- and alpha-chain knockout mice, deficient in gammadelta and alphabeta T cells, respectively, were found to be resistant to disseminated candidiasis of endogenous origin and to acute systemic candidiasis (resulting from intravenous injection).
Jones-Carson
J
J
Division of Infectious Diseases, University of Colorado Health Science Center, Denver, Colorado, USA.
Vazquez-Torres
A
A
Warner
T
T
Balish
E
E
D000818:Animals; D001921:Brain / Q000382:microbiology; D002176:Candida albicans / Q000378:metabolism; D002177:Candidiasis / Q000276:immunology*; D015169:Colony Count, Microbial; D004947:Esophagus / Q000382:microbiology / Q000473:pathology; D007668:Kidney / Q000382:microbiology; D008099:Liver / Q000382:microbiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009092:Mucous Membrane / Q000276:immunology / Q000382:microbiology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000502:physiology; D013154:Spleen / Q000382:microbiology; D013270:Stomach / Q000382:microbiology / Q000473:pathology; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D013997:Time Factors
D011948:Receptors, Antigen, T-Cell