Cell-substrate interactions and signaling through ILK.
Interactions between cells and the extracellular matrix (ECM) result in the regulation of cell growth, cell differentiation and cell migration. These interactions are mediated by integrins and growth factor receptors and intracellular effectors that couple these receptors to downstream components are key to the transduction of ECM signals. This review summarizes recent advances in our understanding of signal transduction via integrins, focusing on the role of integrin-linked kinase in some of these pathways. Research into this interesting protein is uncovering novel aspects of coordinated signaling by the ECM and growth factors.
Dedhar
S
S
Department of Biochemistry, University of British Columbia, BC Cancer Agency and Vancouver Hospital, Jack Bell Research Center, Vancouver, BC, V6H 3Z6, Canada. sdedhar@interchange.ubc.ca
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D016023:Integrins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction; D000099200:Scaffold Protein ILK
D016023:Integrins; D017346:Protein Serine-Threonine Kinases; D000099200:Scaffold Protein ILK