title: Identification of a novel HLA-Cw*07 variant (Cw*0714) in a German Caucasian family.
abstract: We report herein the identification of a new HLA-Cw*07 allele in two members of a German Caucasian family. This novel allele, designated as Cw*0714, differs from Cw*07011 and Cw*0706 by two nucleotide changes: one at codon 66 (AAC-->AAG) in the exon 2, leading to an amino acid change from Asn to Lys; and another silent substitution at codon 99 (TAT-->TAC) in the exon 3. The latest substitution (T-->C at the third position of codon 99) was not seen in any of the HLA-Cw*07 alleles reported so far, thus being characteristic to the new HLA-Cw*0714 allele.
authors.affiliation: Servei d'Immunologia, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Lozano
authors.forename: M T
authors.initials: MT
authors.lastname: Arias
authors.forename: J M
authors.initials: JM
authors.lastname: Vilà
authors.forename: I
authors.initials: I
authors.lastname: Gimferrer
authors.forename: L
authors.initials: L
authors.lastname: Places
authors.forename: A
authors.initials: A
authors.lastname: Hummler
authors.forename: G
authors.initials: G
authors.lastname: Ehninger
authors.forename: J
authors.initials: J
authors.lastname: Martorell
authors.forename: J
authors.initials: J
authors.lastname: Vives
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D015236:HLA-C Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D044465:White People / Q000235:genetics*
chemical_list: D015236:HLA-C Antigens