Transtentorial cerebellar c-jun expression after focal cerebral cortical injury in mice.
Delayed and remote effect of focal cerebral cortical lesion on cerebellum remains unclear. The c-Jun, an inducible transcription factor of cellular immediate early gene, is the predominant transcription factor and consistent marker for neurons that respond to stress or injury. We use a mouse cryogenic injury model to study the spatial and temporal changes of c-jun in the cerebellum after focal neocortical lesion. A transient and moderate expression of c-jun mRNA was found in the cerebellum with central dominance since 3 day postinjury and gradually subsided within 2 weeks. A distinct increment of c-Jun protein expression in Purkinje cells of the bilateral cerebellar hemispheres with focal connotation in the vermis was detected since 1 week postinjury. These findings suggest that the delayed and remote c-jun expression of the cerebellum, functionally connected with the cerebral cortex, indicate transneuronal gene activation.
Liu
J S
JS
Department of Neurology, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, San-Ming District, Kaohsiung City, Taiwan.
Chang
Y Y
YY
Wu
H S
HS
Huang
C Y
CY
Chen
W H
WH
Lan
M Y
MY
Kao
Y F
YF
Chen
S S
SS
D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D002531:Cerebellum / Q000378:metabolism*; D003080:Cold Temperature / Q000009:adverse effects; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D051379:Mice; D010296:Parietal Lobe / Q000473:pathology*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D011689:Purkinje Cells / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors
D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger