Single inoculation of replication-defective adenovirus-vectored vaccines at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies.
In neonates, one limitation of vaccination is its inhibition by maternal antibodies. We show that piglets vaccinated intramuscularly once at birth with recombinant replication-defective adenoviruses developed comparable neutralizing antibody response against pseudorabies virus, independently of the presence or absence of maternal antibodies, and were partially protected against challenge 16 weeks later.
Monteil
M
M
Unite de Génétique Moléculaire, Génétique virale, INRA, Ecole Nationale Vétérinaire, 7 avenue du Général de Gaulle, 94704, Maisons Alfort, France.
Le Pottier
M F
MF
Ristov
A A
AA
Cariolet
R
R
L'Hospitalier
R
R
Klonjkowski
B
B
Eloit
M
M
D000256:Adenoviridae / Q000235:genetics / Q000276:immunology*; D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D011558:Herpesvirus 1, Suid / Q000235:genetics; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007273:Injections, Intramuscular; D051379:Mice; D011557:Pseudorabies / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology*
D000914:Antibodies, Viral; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; C107752:glycoprotein D, pseudorabies virus; C070915:glycoprotein gII, pseudorabies virus; C042966:pseudorabies virus glycoproteins