Calcium channelopathies.
Calcium is an important intracellular signaling molecule, and altered calcium channel function can cause widespread cellular changes. Genetic mutations in calcium channels that cause what appear to be trivial alterations of calcium currents in vitro can result in serious diseases in muscles and the nervous system. This article reviews calcium channelopathies in humans and mice.
Lorenzon
N M
NM
Department of Anatomy & Neurobiology, Colorado State University, Fort Collins, USA.
Beam
K G
KG
D000818:Animals; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D004594:Electrophysiology; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D009135:Muscular Diseases / Q000235:genetics*; D009154:Mutation / Q000502:physiology*; D009422:Nervous System Diseases / Q000235:genetics* / Q000378:metabolism; D013329:Structure-Activity Relationship
D015220:Calcium Channels