title: Antinociceptive activity of I3,II8-binaringenin, a biflavonoid present in plants of the guttiferae.
abstract: This paper describes the antinociceptive action of 13,118-binaringenin (GB-1a), a biflavonoid isolated from Clusia columnaris and present in several plants of the family Guttiferae, in a writhing test and a formalin test. It was found that it exhibits potent and dose-related antinociceptive action in both experimental models, with ID50 values of 22 mumol/kg against the writhing test and 28 mumol/kg against the second phase of the formalin test. It was more potent than some well-known analgesic drugs used as reference. Based on a hot-plate test its mechanism of action seems to be unrelated with the opioid receptors.
authors.forename: M
authors.initials: M
authors.lastname: Bittar
authors.forename: M M
authors.initials: MM
authors.lastname: de Souza
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
authors.forename: R
authors.initials: R
authors.lastname: Lento
authors.forename: F
authors.initials: F
authors.lastname: Delle Monache
authors.forename: V
authors.initials: V
authors.lastname: Cechinel Filho
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D044946:Biflavonoids; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010944:Plants / Q000737:chemistry*
chemical_list: D018712:Analgesics, Non-Narcotic; D044946:Biflavonoids; D005419:Flavonoids; C406718:I3,II8-binaringenin