title: Pediatric marrow transplantation for acute leukemia using unrelated donors and T-replete or -depleted grafts: a case-matched analysis.
abstract: A retrospective, case-matched analysis of the short-term toxicity, risk of GVHD and relapse as well as outcome in pediatric unrelated marrow transplantation was conducted by comparing recipients of T-replete and -depleted grafts in a two-center setting. Both groups contained 30 patients with acute leukemia matched by age at transplant, gender, primary diagnosis and disease status. Acute (90% vs 53%) and chronic (48% vs 0%) GVHD were more common among recipients of T-replete grafts. No significant differences in graft rejection/failure or viral infections were encountered between the two groups. Relapses were more prevalent (37% vs 15%) among recipients of T-depleted grafts. Outcome (EFS) was similar in the two groups. Consequently, in the analysis of transplant outcome, the higher risk of procedure-related, toxic complications among pediatric recipients of T-replete marrow grafts appears to be balanced by an increased risk of relapse among the recipients of T-depleted grafts.
authors.affiliation: Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, University of Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Vettenranta
authors.forename: U M
authors.initials: UM
authors.lastname: Saarinen-Pihkala
authors.forename: J
authors.initials: J
authors.lastname: Cornish
authors.forename: C
authors.initials: C
authors.lastname: Steward
authors.forename: D
authors.initials: D
authors.lastname: Pamphilon
authors.forename: L
authors.initials: L
authors.lastname: Hovi
authors.forename: A
authors.initials: A
authors.lastname: Oakhill
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D016026:Bone Marrow Transplantation; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000276:immunology / Q000628:therapy*; D008212:Lymphocyte Depletion; D008297:Male; D012189:Retrospective Studies; D014181:Transplantation Immunology; D014184:Transplantation, Homologous; D016896:Treatment Outcome