title: [Diabetic muscle infarct].
abstract: METHODS
  A 64-year-old diabetic man with secondary failure of treatment with oral hypoglycemic agents was admitted to our clinical department to initiate insulin therapy. The patient was otherwise in good health. Before his dismissal he acutely developed symptoms of pain in his left calf. In addition, the patient was unable to move his left leg and presented palpable pea-sized nodules of his left calf.
  
  
  METHODS
  Laboratory investigations revealed elevated serum creatine kinase levels on day two after the onset of clinical symptoms (peak value: 2238 U/I). There was evidence for antinuclear antibodies, c-reactive protein was normal. An ultrasound investigation showed a focal edema or bleeding located to the musculus gastrocnemius. Duplex-sonography excluded thrombosis or embolisation. Magnetic resonance imaging showed a diffuse enhancement of signal intensity within the musculus soleus and in areals of the musculus gastrocnemius, as signs of increased blood supply. All clinical findings were consistent with the diagnosis of diabetic muscle infarction.
  
  
  METHODS
  Under symptomatic treatment with tramadol, diclofenac ointment, and fragmented heparin serum creatine kinase returned to normal levels (105 U/I) within 14 days. In accordance, symptoms of local pain disappeared completely. After two weeks of treatment the patient was able to move his leg without pain.
  
  
  CONCLUSIONS
  This is the first presentation of a patient with diabetic muscle infarction from the onset of symptoms until full recovery. In addition, this case confirms previous descriptions that this condition can be diagnosed by clinical and sonographic findings in combination with magnetic resonance imaging without invasive histologic techniques.
authors.affiliation: Deutsches Diabetes-Forschungsinstitut, Heinrich-Heine-Universität Düsseldorf.
authors.forename: H S
authors.initials: HS
authors.lastname: Willenberg
authors.forename: K
authors.initials: K
authors.lastname: Wiefels
authors.forename: E
authors.initials: E
authors.lastname: Driesch
authors.forename: H
authors.initials: H
authors.lastname: Hauner
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis*; D003925:Diabetic Angiopathies / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007238:Infarction / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000473:pathology; D014463:Ultrasonography