title: [Nitric oxide inhalation as an effective therapy for acute respiratory distress syndrome due to near-drowning: a case report].
abstract: A 16-year-old boy with acute respiratory distress syndrome (ARDS) due to near-drowning was admitted to our hospital. ARDS was treated with low-level nitric oxide (NO) inhalation (ranging from 4 ppm to 1 ppm) for 24 days. Oxygenation was improved and pulmonary hypertension was reduced after NO inhalation, but systemic blood pressure, heart rate, and cardiac output were not affected. PaO2 improved from 153 Torr to 354 Torr under identical ventilating conditions (F1O2 1.0), and mean pulmonary arterial pressure fell from 40 mm Hg to 27 mmHg. It has been reported that NO inhalation alleviates ventilation-flow mismatch and pulmonary hypertension. It is unclear, however, whether this therapy improves the prognosis for ARDS. In our patient, NO inhalation was effective in alleviating the oxygenation impairment and pulmonary hypertension associated with ARDS.
authors.affiliation: First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: S
authors.initials: S
authors.lastname: Hirosako
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: N
authors.initials: N
authors.lastname: Saita
authors.forename: M
authors.initials: M
authors.lastname: Suga
authors.forename: I
authors.initials: I
authors.lastname: Kukita
authors.forename: K
authors.initials: K
authors.lastname: Okamoto
authors.forename: M
authors.initials: M
authors.lastname: Ando
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015701:Near Drowning / Q000150:complications*; D009569:Nitric Oxide / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000628:therapy*; D012138:Respiratory Therapy; D016896:Treatment Outcome
chemical_list: D009569:Nitric Oxide