Strategies for targeting complement inhibitors in ischaemia/reperfusion injury.
A transplanted organ suffers inherently from an ischaemic insult and subsequent reperfusion injury. The severity of such early events is thought to influence the success of the transplant procedure, not only in the immediate post-transplant period, but also to predispose the graft to both acute and chronic rejection. In this paper, we review the influence of the complement system upon ischaemia,reperfusion injury. The recognition of the involvement of complement has led to novel strategies to try to modulate ischaemia/reperfusion injury, some of which we have summarized. Finally, we note our own strategy to target complement inhibition in ischaemic tissues.
Dong
J
J
Department of Nephrology & Transplantation, King's College, University of London, Guy's Hospital, UK.
Pratt
J R
JR
Smith
R A
RA
Dodd
I
I
Sacks
S H
SH
D000818:Animals; D003167:Complement Activation; D003169:Complement Inactivator Proteins / Q000378:metabolism* / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology; D008954:Models, Biological; D016377:Organ Transplantation / Q000009:adverse effects; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology*
D003169:Complement Inactivator Proteins