title: Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study.
abstract: This study assesses the cross-sectional relationship between serum cholesterol level and dementia, controlling for apolipoprotein E (apoE) genotype, in a nested case-control study of 334 elderly French subjects aged 73 and over who participated in the PAQUID study (37 demented subjects and 297 nondemented controls). A diagnosis of dementia was established by two-step screening: (1) psychometric testing and DSM-III-R criteria and (2) neurologist's confirmation. Cholesterol, its fractions and apoE genotype were determined from a blood sample. Elevated high-density lipoprotein cholesterol was associated with a significantly decreased risk of dementia, independent of apoE status and other potential confounding variables, suggesting that cholesterol fractions could be involved in both Alzheimer's disease and vascular dementia.
authors.affiliation: INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Bonarek
authors.forename: P
authors.initials: P
authors.lastname: Barberger-Gateau
authors.forename: L
authors.initials: L
authors.lastname: Letenneur
authors.forename: V
authors.initials: V
authors.lastname: Deschamps
authors.forename: A
authors.initials: A
authors.lastname: Iron
authors.forename: B
authors.initials: B
authors.lastname: Dubroca
authors.forename: J F
authors.initials: JF
authors.lastname: Dartigues
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000032:analysis* / Q000235:genetics; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies
chemical_list: D001057:Apolipoproteins E; D008076:Cholesterol, HDL