Granulocyte selected live Salmonella enteritidis vaccine is species specific.
Selection of Salmonellae from granulocytes may result in safe and effective vaccine strains. We demonstrated that the reduced virulence of such strains is limited to the species in which the selection was made. Repeated (sequential) selection of Salmonella enteritidis from chicken granulocytes yielded an avirulent strain for chickens. Repeated (sequential) selection of Salmonella enteritidis from pig granulocytes (neutrophils) yielded a strain that was comparable to the original wildtype strain.
Kramer
T
T
Veterinary Medical Research Institute, Iowa State University, 1802 Elwood Drive, Ames, IA 50011, USA.
Vote
J
J
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002645:Chickens; D004531:Eggs / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D006098:Granulocytes / Q000382:microbiology*; D012477:Salmonella enteritidis / Q000276:immunology*; D013045:Species Specificity; D013552:Swine
D001428:Bacterial Vaccines