title: Time course of response to ozone exposure in healthy adult females.
abstract: Ozone exposure causes acute decrements in pulmonary function, increases airway responsiveness, and changes the breathing pattern. We examined these responses in 19 ozone-responsive (DeltaFEV(1) > 5%) young females exposed to both air and 0.35 ppm ozone. The randomized 75-min exposures included two 30-min exercise periods at V(E) approximately 40 L/min. Responses were measured before, during, and after exposure and at 18 and 42 h postexposure. FVC, FEV(1), and FIV(0.5) decreased (p <.01) immediately postexposure by 13.2%, 19.9%, and 20.8%, respectively, and the airway responsiveness was significantly increased. Raw increased (p <.05), while TGV remained essentially unchanged. At 18 h postexposure, the airways were still hyperresponsive and FEV(1) and FIV(0.5) were still 5% below the preexposure levels. There were no residual effects in any of the variables at 42 h postexposure. During exercise in ozone the tidal volume was decreased (-14%) and respiratory frequency increased (+15%). The changes in airway responsiveness were not related to changes in spirometric measurements. We found no significant differences between postair and postozone mouth occlusion pressure (Pm(0.1)) and the hypercapnic response to CO(2) rebreathing. We conclude that ozone induced typical acute changes in airway responsiveness and that ventilatory (exercise), spirometric (inspiratory and expiratory), and plethysmographic pulmonary function may show some residual effects for up to 18 h after exposure. The ozone-induced alteration in breathing pattern during exercise does not appear to be related to a change in ventilatory drive.
authors.affiliation: National Center for Environmental Assessment, United States Environmental Protection Agency, MD 52, Research Triangle Park, NC 27711, USA. Folinsbee.Lawrence@epa.gov
authors.forename: L J
authors.initials: LJ
authors.lastname: Folinsbee
authors.forename: M J
authors.initials: MJ
authors.lastname: Hazucha
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D001273:Atmosphere Exposure Chambers; D002245:Carbon Dioxide / Q000008:administration & dosage; D005080:Exercise Test; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D016210:Methacholine Chloride / Q000494:pharmacology; D010126:Ozone / Q000008:administration & dosage / Q000009:adverse effects*; D010991:Plethysmography / Q000187:drug effects; D011897:Random Allocation; D012129:Respiratory Function Tests; D013147:Spirometry; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D016210:Methacholine Chloride; D002245:Carbon Dioxide; D010126:Ozone