Effect of fluconazole on the pharmacokinetics of doxorubicin in nonhuman primates.
Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.
Warren
K E
KE
Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-1928, USA. warrenk@exchange.nih.gov
McCully
C M
CM
Walsh
T J
TJ
Balis
F M
FM
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics*; D000935:Antifungal Agents / Q000494:pharmacology*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004317:Doxorubicin / Q000493:pharmacokinetics*; D004347:Drug Interactions; D015725:Fluconazole / Q000494:pharmacology*; D006207:Half-Life; D007275:Injections, Intravenous; D008253:Macaca mulatta; D008297:Male; D013050:Spectrometry, Fluorescence
D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D004317:Doxorubicin; D015725:Fluconazole