Antibiotic efficacy in vivo predicted by in vitro activity.
A brief overview of arguments found in the literature is presented to apply the E(max) concept to experimental studies of antibiotics as well as to their clinical application. It may turn out to be more flexible than schedules based on arbitrary parameters that have the disadvantage that they have to be proven in each individual situation.
Mattie
H
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Department of Infectious Diseases, C5-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008954:Models, Biological
D000900:Anti-Bacterial Agents