Synthesis of new fluidity-enhanced amphiphilic compounds for soluble protein two-dimensional crystallization purpose.
The synthesis of new amphiphilic compounds is described. The structures are rationally designed for soluble protein two-dimensional (2D) crystallization purpose. Special attention is devoted to fluidity properties expected of resulting monolayers. A series of 13 compounds was prepared containing unsaturated, branched or fluorinated alkyl chains. Structures are either symmetrical or dissymmetrical and present a hydroxyl group as polar head, eventually complemented with two other 'secondary' hydrophilic functions.
Nuss
S
S
Laboratoire de Synthèse, Bioorganique associé au CNRS, Université Louis Pasteur, Illkirch, France.
Mioskowski
C
C
Lebeau
L
L
D003460:Crystallization; D015195:Drug Design; D007202:Indicators and Reagents / Q000138:chemical synthesis*; D008560:Membrane Fluidity; D015394:Molecular Structure; D009675:Novobiocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012995:Solubility
D007202:Indicators and Reagents; D011506:Proteins; D009675:Novobiocin