title: Efficacy of an ivermectin controlled-release capsule against some rarer nematode parasites of sheep.
abstract: A controlled trial was conducted to evaluate the efficacy of the intraruminal ivermectin controlled-release capsule (CRC) (IVOMEC Maximizer CR Capsule for Sheep, Merial Ltd.) against induced incoming third-stage larvae and established adult infections with some rarer gastrointestinal nematode parasites of sheep. Twenty-one worm-free lambs were allocated by restricted randomisation based on body weight within sex to one of the following treatments: unmedicated control, ivermectin CRC given on Day 0 prior to induced infection, and ivermectin CRC given on Day 70 after establishment of induced infection. The ivermectin CRC delivers ivermectin at a minimum dose rate of 20 microg/kg/day for 100 days. Infections were induced by daily administration of third-stage larvae for five consecutive days. Nematodes were counted on Day 84, 14 days after treatment of established infection. The treatment with the ivermectin CRC prevented the establishment of Ostertagia leptospicularis, O. ostertagi, Bunostomum trigonocephalum, Cooperia oncophora, C. punctata, C. surnabada, Nematodirus helvetianus, N. roscidus and Strongyloides papillosus by >99% as compared with the untreated controls (p < 0.01). The administration of the ivermectin CRC reduced established adult infections of O. ostertagi, B. trigonocephalum, C. oncophora, C. punctata, C. surnabada, N. roscidus and S. papillosus by >99% (p < 0.01), and reduced established adult infections of O. leptospicularis and N. helvetianus by 96.5 and 98.4% (p < 0.01), respectively.
authors.affiliation: Kathrinenhof Research Center, Merial GmbH, Rohrdorf-Lauterbach, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Rehbein
authors.forename: D
authors.initials: D
authors.lastname: Barth
authors.forename: M
authors.initials: M
authors.lastname: Visser
authors.forename: R
authors.initials: R
authors.lastname: Winter
authors.forename: W K
authors.initials: WK
authors.lastname: Langholff
mesh_terms: D000018:Abomasum / Q000469:parasitology; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D002214:Capsules; D003692:Delayed-Action Preparations; D005260:Female; D007421:Intestine, Small / Q000469:parasitology; D007559:Ivermectin / Q000008:administration & dosage / Q000592:standards / Q000627:therapeutic use*; D008297:Male; D009348:Nematoda / Q000302:isolation & purification; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D011897:Random Allocation; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D018709:Statistics, Nonparametric
chemical_list: D000871:Anthelmintics; D002214:Capsules; D003692:Delayed-Action Preparations; D007559:Ivermectin