title: Effects of omeprazole paste on healing of spontaneous gastric ulcers in horses and foals: a field trial.
abstract: A multicentre, blinded, randomised complete-block, field trial was conducted with 140 horses and foals age 4 weeks-28 years to determine if omeprazole paste is effective and safe in promoting healing of spontaneous gastric ulcers under a variety of field conditions and in different breeds and ages of horses. Horses in the study had gastric ulceration as determined by gastroscopy and were divided into replicates of 4 or 5 animals. One horse in each replicate was assigned randomly to receive an empty omeprazole syringe (sham-dosed control) and the remaining horses received omeprazole paste once daily for 28 days. Gastroscopy was repeated at the end of the study. Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls. Ulcers were improved in 32.4 and 99.0% of the control and omeprazole groups, respectively. Ulcers were completely healed in 8.9 and 86.7% of the control and omeprazole groups, respectively. Under typical field conditions, omeprazole was effective at enhancing healing of spontaneous gastric ulcers in horses of a variety of ages and breeds.
authors.affiliation: College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: MacAllister
authors.forename: R L
authors.initials: RL
authors.lastname: Sifferman
authors.forename: S R
authors.initials: SR
authors.lastname: McClure
authors.forename: G W
authors.initials: GW
authors.lastname: White
authors.forename: N J
authors.initials: NJ
authors.lastname: Vatistas
authors.forename: J E
authors.initials: JE
authors.lastname: Holste
authors.forename: G F
authors.initials: GF
authors.lastname: Ericcson
authors.forename: J L
authors.initials: JL
authors.lastname: Cox
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001947:Breeding; D004311:Double-Blind Method; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005773:Gastroscopy / Q000662:veterinary; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D006799:Housing, Animal; D008297:Male; D009824:Ointments; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome; D014481:United States
chemical_list: D004791:Enzyme Inhibitors; D009824:Ointments; D009853:Omeprazole