Chronic immobilization-induced stress increases plasma testosterone and delays testicular maturation in pubertal rats.
We investigated whether chronic stress, applied from prepuberty to early puberty, interferes with the spermatogenic and androgenic testicular functions. Male pubertal rats (40 days old) were immobilized 6 h per day for 15 days. Plasma concentrations of corticosterone, prolactin and testosterone were significantly augmented following immobilization, whereas plasma luteinizing hormone decreased and follicle-stimulating hormone was not altered. Acute immobilization (5 min) increased prolactin and testosterone levels in control rats but caused a significantly higher increase in these hormones when superimposed on chronic stress. A lower extent of testicular maturation was observed in pubertal rats immobilized from prepuberty.
Almeida
S A
SA
Department of Physiology, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
Petenusci
S O
SO
Franci
J A
JA
Rosa e Silva
A A
AA
Carvalho
T L
TL
D000818:Animals; D003345:Corticosterone / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D007103:Immobilization / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology; D013312:Stress, Physiological / Q000097:blood* / Q000473:pathology*; D013737:Testis / Q000254:growth & development*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003345:Corticosterone