title: Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.).
abstract: The effect of exposure to sublethal concentrations of the organophosphate pesticide, quinalphos (1.12, 0.22 mg/l) on biochemical parameters of muscle and enzyme activities in brain, liver and kidney of the Indian major carp, Labeo rohita was studied after 15, 30 and 45 days. The muscle protein and RNA levels decreased whereas DNA levels and acid phosphatase were elevated. Similarly, alkaline phosphatase was depleted. The brain acetyl cholinesterase activity was decreased most (-75.43%) in 1.12 mg/l concentration over a period of 45 days. Lactic dehydrogenase levels in brain and liver were elevated whereas in the kidney they were inhibited. Succinic dehydrogenase and adenosine triphosphatase activities were depleted in brain, liver and kidney. The effects have been discussed for different organ tissues in relation to the pesticide.
authors.affiliation: Aquatic Animal Health Division, Central Institute of Freshwater Aquaculture, Kausalyaganga, Bhubaneswar, India.
authors.forename: B K
authors.initials: BK
authors.lastname: Das
authors.forename: S C
authors.initials: SC
authors.lastname: Mukherjee
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism; D000135:Acid Phosphatase / Q000187:drug effects / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000187:drug effects* / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002347:Carps; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000201:enzymology; D009946:Organothiophosphorus Compounds / Q000633:toxicity*; D011506:Proteins / Q000187:drug effects / Q000378:metabolism; D012313:RNA / Q000187:drug effects / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D013995:Time
chemical_list: D007306:Insecticides; D009946:Organothiophosphorus Compounds; D011506:Proteins; C009145:quinalphos; D012313:RNA; D004247:DNA; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000110:Acetylcholinesterase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases