title: Addition of inulin to breakfast does not acutely affect serum ionized calcium and parathyroid hormone concentrations.
abstract: OBJECTIVE
  The aim of the present study was to investigate the effects of inulin on calcium metabolism. The study consisted of two separate parts both of which had a randomized two-period cross-over design.
  
  
  METHODS
  Fifteen young healthy women volunteered to participate in this study. During the first part of the study, cheese containing 210 mg of calcium, either with 15 g of inulin or without any inulin, was ingested at breakfast, and in the second part, 210 mg of calcium as a supplement, either with 15 g inulin or without inulin, was ingested. The whole day's diet was standardized. Before breakfast, and 2, 4, 6 and 8 h after breakfast, a blood sample was taken, and intact parathyroid hormone (iPTH), ionized calcium (iCa) and total calcium were measured. Urine was collected throughout the day, and the 8-, 12- and 24-hour calcium excretion was calculated.
  
  
  RESULTS
  The iPTH or iCa concentration curves (AUCs) did not differ over 8 h, whether or not inulin was consumed at breakfast. The postload urinary calcium excretion was not affected by the inulin.
  
  
  CONCLUSIONS
  Fifteen grams of inulin in fresh cheese or with a calcium supplement (210 mg Ca) taken at breakfast does not acutely affect the markers of calcium metabolism as opposed to a corresponding breakfast without inulin.
authors.affiliation: Valio Ltd R&D Centre, Division of Nutrition, University of Helsinki, Helsinki, Finland.
authors.forename: U
authors.initials: U
authors.lastname: Teuri
authors.forename: M
authors.initials: M
authors.lastname: Kärkkäinen
authors.forename: C
authors.initials: C
authors.lastname: Lamberg-Allardt
authors.forename: R
authors.initials: R
authors.lastname: Korpela
mesh_terms: D000328:Adult; D019540:Area Under Curve; D002118:Calcium / Q000097:blood* / Q000652:urine; D018592:Cross-Over Studies; D019587:Dietary Supplements; D004435:Eating; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007444:Inulin / Q000494:pharmacology*; D010281:Parathyroid Hormone / Q000097:blood*
chemical_list: D010281:Parathyroid Hormone; D007444:Inulin; D002118:Calcium