[The use of psychotropic drugs in an Italian psychiatric hospital: a two-year-long follow-up study].
OBJECTIVE
Following the introduction of guidelines of rational drug use, the pharmacoepidemiology of psychotropic drugs was investigated in a sample of long-stay patients living in a Italian psychiatric hospital.


METHODS
A prospective, longitudinal two-year follow-up study was carried out. Information about sociodemographic and clinical characteristics of the inpatient population, and about medications prescribed, was collected at baseline and after one and two years of follow-up.


METHODS
Three wards of the psychiatric hospital of Milan.


METHODS
Number of patients taking psychotropic drugs, number of patients taking more than one neuroleptic or benzodiazepine, mean neuroleptic dose, psychopathological status according to the Brief Psychiatric Rating Scale (BPRS).


RESULTS
70 patients were recruited and followed for two years. At follow-up a reduction in the number of patients taking neuroleptic drugs was recorded, together with a 50% decrease in the number of patients taking more than one neuroleptic. A reduction in the use of depot formulations was in addition shown. Patients taking benzodiazepines decreased of 50%. According to the BPRS, no psychopatological changes were observed during the study.


CONCLUSIONS
These data suggest that education in psychopharmacology may guide towards a more rational use of drugs; longitudinal clinical audits should be implemented to monitor everyday practice.
Brambilla
P
P
Istituto di Ricerche Farmacologiche Mario Negri Milano. sxbra@tin.it
Monzani
E
E
Alessandri
M
M
Frova
M
M
Barbui
C
C
Erlicher
A
A
D000328:Adult; D000368:Aged; D010054:Brief Psychiatric Rating Scale; D002391:Catchment Area, Health; D004363:Drug Utilization; D005260:Female; D005500:Follow-Up Studies; D006778:Hospitals, Psychiatric / Q000706:statistics & numerical data*; D006801:Humans; D007558:Italy; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000534:rehabilitation; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000627:therapeutic use*
D011619:Psychotropic Drugs