Similar effects of diets high in oleic or linoleic acids on coagulation and fibrinolytic factors in healthy humans.
OBJECTIVE
Monounsaturated fatty acids (MUFA) have been shown to be beneficial. Their haemostatic effects, however, are poorly known. We compared the effects of oleic acid (OA) and linoleic acid (LA) on variables related with coagulation and fibrinolysis in healthy subjects.


RESULTS
Thirty-eight healthy volunteers (20 women, 18 men; mean age 27) consumed a saturated fat baseline diet for four weeks and were then switched to either a high LA diet (11.5 en%) or a high OA diet (18.0 en%) for another four weeks when nearly all food was provided for the whole day. A control group of 13 subjects consumed their habitual diet throughout the study. No differences between the OA and LA diets were found in the plasma levels of fibrinogen, plasminogen activator inhibitor, antithrombin III, von Willebrand factor antigen or D-dimers. Factor FVII coagulant activity was significantly lower after the OA diet.


CONCLUSIONS
The results indicate largely similar effects for OA and LA on factors related with coagulation and fibrinolysis in humans. The effects of dietary fatty acid composition on FVII coagulant activity should be further studied.
Turpeinen
A M
AM
Department of Applied Chemistry and Microbiology (Nutrition), University of Helsinki, Finland.
Mutanen
M
M
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects* / Q000502:physiology; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D006490:Hemostatics / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008041:Linoleic Acids / Q000008:administration & dosage*; D008297:Male; D009829:Oleic Acids / Q000008:administration & dosage*; D012016:Reference Values; D012680:Sensitivity and Specificity
D004041:Dietary Fats; D005227:Fatty Acids; D006490:Hemostatics; D008041:Linoleic Acids; D009829:Oleic Acids