Phages will out: strategies of host cell lysis.
Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.
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Dept of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. ryland@tamu.edu
Wang
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Roof
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D000595:Amino Acid Sequence; D001435:Bacteriophages / Q000378:metabolism* / Q000472:pathogenicity; D002463:Cell Membrane Permeability; D010450:Endopeptidases / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000821:virology; D008565:Membrane Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D008565:Membrane Proteins; C108624:S holin, bacteriophage lambda; D014764:Viral Proteins; C082268:Rz protein, bacteriophage lambda; D010450:Endopeptidases; C001143:endolysin