DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
Geijtenbeek
T B
TB
Department of Tumor Immunology, University Medical Center St. Radboud, Nijmegen, The Netherlands.
Kwon
D S
DS
Torensma
R
R
van Vliet
S J
SJ
van Duijnhoven
G C
GC
Middel
J
J
Cornelissen
I L
IL
Nottet
H S
HS
KewalRamani
V N
VN
Littman
D R
DR
Figdor
C G
CG
van Kooyk
Y
Y
D015704:CD4 Antigens / Q000502:physiology; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000821:virology*; D015815:Cell Adhesion Molecules / Q000502:physiology; D002465:Cell Movement; D002478:Cells, Cultured; D002584:Cervix Uteri / Q000166:cytology; D018920:Coculture Techniques; D003713:Dendritic Cells / Q000276:immunology / Q000502:physiology* / Q000821:virology; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D015658:HIV Infections / Q000635:transmission*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D037102:Lectins / Q000502:physiology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000821:virology; D008221:Lymphoid Tissue / Q000166:cytology / Q000821:virology; D046911:Macromolecular Substances; D008297:Male; D009092:Mucous Membrane / Q000166:cytology / Q000821:virology*; D019713:Receptors, CCR5 / Q000502:physiology; D015728:Receptors, HIV / Q000502:physiology*; D012007:Rectum / Q000166:cytology; D014162:Transfection; D014599:Uterus / Q000166:cytology
D015704:CD4 Antigens; D015815:Cell Adhesion Molecules; D015699:HIV Envelope Protein gp120; D037102:Lectins; D046911:Macromolecular Substances; D019713:Receptors, CCR5; D015728:Receptors, HIV