A transcript map of a 10-Mb region of chromosome 19: a source of genes for human disorders, including candidates for genes involved in asthma, heart defects, and eye development.
Several projects have produced maps of the physical position of genes within the human genome, either on a genome-wide scale or of a more detailed subsection of a chromosome. However, these maps largely rely on the mapping of expressed sequences (cDNAs and ESTs) back onto physical maps by their localization onto specific fragments of DNA within the radiation hybrid panels. In this report we present a gene map of a section of chromosome 19 that has been derived by combining the use of a method of gene identification (exon trapping) that does not rely on expression patterns, with data available in the genome databases to produce a fine-detailed transcript map. This map also provides several potential candidates for disorders that map to this region of the genome. Details of the maps and more detailed descriptions of cosmid contigs, exon sequences, and expression patterns for the 96 exons that form the basis of this transcript map are available on a series of Web pages that are referenced in this report. These Web pages can be accessed from http://www.nottingham.ac.uk/ pdzmgh/tm/livemap19q. html.
Hamshere
M
M
Institute of Genetics, University of Nottingham, Nottingham, NG7 2UH, United Kingdom. marion.hamshere@nottingham.ac.uk
Cross
S
S
Daniels
M
M
Lennon
G
G
Brook
J D
JD
D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics; D020224:Expressed Sequence Tags; D005123:Eye / Q000196:embryology; D005124:Eye Abnormalities / Q000235:genetics*; D005796:Genes; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D020407:Internet; D012333:RNA, Messenger / Q000235:genetics*; D014158:Transcription, Genetic
D018076:DNA, Complementary; D012333:RNA, Messenger