title: Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy.
abstract: Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series of affected subjects was genotyped for a set of genetic markers along the tau protein gene. A specific haplotype is significantly overrepresented in patients versus controls. This haplotype is the same already reported in association with progressive supranuclear palsy. These data show that corticobasal degeneration and progressive supranuclear palsy, in addition to several clinical, pathological, and molecular features, may have the same genetic background.
authors.affiliation: Department of Oncology, Biology and Genetics, University of Genova, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Di Maria
authors.forename: M
authors.initials: M
authors.lastname: Tabaton
authors.forename: T
authors.initials: T
authors.lastname: Vigo
authors.forename: G
authors.initials: G
authors.lastname: Abbruzzese
authors.forename: E
authors.initials: E
authors.lastname: Bellone
authors.forename: C
authors.initials: C
authors.lastname: Donati
authors.forename: E
authors.initials: E
authors.lastname: Frasson
authors.forename: R
authors.initials: R
authors.lastname: Marchese
authors.forename: P
authors.initials: P
authors.lastname: Montagna
authors.forename: D G
authors.initials: DG
authors.lastname: Munoz
authors.forename: P P
authors.initials: PP
authors.lastname: Pramstaller
authors.forename: G
authors.initials: G
authors.lastname: Zanusso
authors.forename: F
authors.initials: F
authors.lastname: Ajmar
authors.forename: P
authors.initials: P
authors.lastname: Mandich
mesh_terms: D000368:Aged; D000483:Alleles; D001480:Basal Ganglia Diseases / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D013494:Supranuclear Palsy, Progressive / Q000235:genetics*