title: Regulation of early expression of Dlx3, a Xenopus anti-neural factor, by beta-catenin signaling.
abstract: The ectoderm of the pre-gastrula Xenopus embryo has previously been shown to be at least partially patterned along the dorsal-ventral axis. The early expression of the anti-neural homeodomain gene Dlx3 is localized to the ventral ectoderm by a mechanism that occurs prior to gastrulation and is independent of the Spemann organizer. The repression of Dlx3 is mediated by signaling though beta-catenin, but is probably not dependent on the induction of the Xnr3 or chordin genes by beta-catenin. We propose a model in which this early regulation of Dlx3 accounts for the pro-neural bias of dorsal ectoderm.
authors.affiliation: Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Beanan
authors.forename: J A
authors.initials: JA
authors.lastname: Feledy
authors.forename: T D
authors.initials: TD
authors.lastname: Sargent
mesh_terms: D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism*; D004475:Ectoderm; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D018021:Lithium Chloride / Q000494:pharmacology; D015398:Signal Transduction; D015534:Trans-Activators; D014157:Transcription Factors / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology* / Q000235:genetics; D051176:beta Catenin
chemical_list: C495266:CTNNB1 protein, Xenopus; D003598:Cytoskeletal Proteins; C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; C093133:SIA1 protein, Xenopus; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; D029867:Xenopus Proteins; C109036:Zic3 protein, Xenopus; D051176:beta Catenin; C094620:nodal3.1 protein, Xenopus; D018021:Lithium Chloride