Hypokalemia-induced ultrastructural, histochemical and connexin-43 alterations resulting in atrial and ventricular fibrillations.
Perfusion of the isolated guinea pig heart with hypokalemic solution provide simple model for examination of the molecular mechanisms involved in the incidence of atrial and/or ventricular fibrillations. The results point out that dispersion of the metabolic and subcellular alterations and heterogenously impaired intercellular coupling might account for electrical disturbances and desynchronization of the myocardium thus facilitate occurrence of fibrillation.
Tribulová
N
N
Institute for Heart Research, Slovak Academy of Sciences, Bratislava. usrdtri@savba.sk
Manoach
M
M
Varon
D
D
Okruhlicová
L
L
Slobodová
Z
Z
Kubovcáková
L
L
D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology*; D018031:Connexin 43 / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006651:Histocytochemistry; D007008:Hypokalemia / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D014693:Ventricular Fibrillation / Q000209:etiology*
D018031:Connexin 43