title: [Skin and osteoarticular bacterial infections of the diabetic foot. Ulcers of the diabetic foot: epidemiology and physiopathology].
abstract: BACKGROUND
  There are more than 2 million diabetics in France. Fifteen percent have suffered at one time or another from a foot ulcer. This condition accounts for 20% of all admissions of diabetic patients and for 50% of corresponding hospitalization stays. Fifteen to 25% of diabetic foot ulcers lead to an amputation, the patients being in the 45-65 year age range. Fifty percent of the amputated patients will have a contralateral amputation within the next 5 years.
  
  
  METHODS
  Diabetic foot ulcers result from damage caused by diabetic neuropathy and micro- or macroangiopathy. Ulceration is favored by usually minimal trauma and secondary infection. The neuropathy causes deformations and sensorial disorders. Repair is hindered by the often precarious vascular supply. Reduced antibacterial defense related to high serum glucose levels and impaired diapedesis favor superinfection.
  
  
  RESULTS
  Careful physical examination and appropriate explorations are required for proper care giving the patient the best chances for cure.
authors.affiliation: Service des Maladies infectieuses-Médecine interne B, Hôtel-Dieu, Nantes.
authors.forename: D
authors.initials: D
authors.lastname: Boutoille
authors.forename: S
authors.initials: S
authors.lastname: Leautez
authors.forename: D
authors.initials: D
authors.lastname: Maulaz
authors.forename: M
authors.initials: M
authors.lastname: Krempf
authors.forename: F
authors.initials: F
authors.lastname: Raffi
mesh_terms: D000368:Aged; D000671:Amputation, Surgical / Q000706:statistics & numerical data; D003920:Diabetes Mellitus / Q000453:epidemiology; D003925:Diabetic Angiopathies / Q000503:physiopathology; D017719:Diabetic Foot / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D003929:Diabetic Neuropathies / Q000503:physiopathology; D016523:Foot Ulcer / Q000453:epidemiology* / Q000503:physiopathology; D005602:France / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged