title: Thrombus within an aortic aneurysm does not reduce pressure on the aneurysmal wall.
abstract: OBJECTIVE
  The role of thrombus within an aneurysm in relation to the risk of rupture is controversial. In literature, reports describing reduction and increase of rupture risk can be found. In the era of endovascular treatment of abdominal aortic aneurysms, a possible reduction of risk of rupture by the presence of thrombus within the aneurysmal sac can be important in relation to the location of an endoleak to the aneurysmal wall and in relation to the effect of the thrombosis of the endoleak, either spontaneously or by intervention.
  
  
  METHODS
  In nine patients who underwent operation for an infrarenal aortic aneurysm by open procedure at the level of the thickest thrombus lining, the pressure within the aneurysmal thrombus (just inside the aneurysmal wall) was measured and compared with the systemic pressure.
  
  
  RESULTS
  Pressure within systemic circulation and aneurysmal thrombus correlated well for the mean pressure (r = 0.90; P <.001) and for pulse pressure (r = 0.74; P <.01) Also, there was agreement between the levels of the mean pressure. Conduction of mean and pulse pressure to the aneurysmal wall was not related to the thickness of the thrombus at the level of the pressure measurement (r = 0.18 and r = 0.08, respectively).
  
  
  CONCLUSIONS
  We conclude that thrombus within the aneurysm does not reduce both the mean and the pulse pressure near the aneurysmal wall and thus will not reduce the risk of rupture of the aneurysm.
authors.affiliation: Department of Surgery, Section Vascular Surgery, Leiden University Medical Center, Leiden, The Netherlands.
authors.forename: G W
authors.initials: GW
authors.lastname: Schurink
authors.forename: J M
authors.initials: JM
authors.lastname: van Baalen
authors.forename: M J
authors.initials: MJ
authors.lastname: Visser
authors.forename: J H
authors.initials: JH
authors.lastname: van Bockel
mesh_terms: D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000503:physiopathology* / Q000601:surgery; D001019:Aortic Rupture / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011312:Pressure; D018570:Risk Assessment; D013927:Thrombosis / Q000503:physiopathology*