title: [Insulin sensitizer and urate metabolism].
abstract: Gout patients often have various characteristics of insulin resistance (IR) syndrome such as glucose intolerance, hyperlipidemia, hypertension and obesity. In addition, epidemiological data suggest that hyperuricemia is associated with higher rates of death due to cardiovascular and cerebrovascular disorders. However, it has not conclusively been shown whether the association between hyperuricemia and increased death rate is secondary to the association between IR and death or hyperuricemia itself is an independent risk of death. It is of interest to examine the effects of insulin sensitizer which was developed recently on serum urate concentration because it may provide a new idea as to the mechanism of the association between IR, hyperuricemia and vascular disorders. In the present paper, we discuss the relevance of IR to hyperuricemia and gout, and show the data of urate and glucose metabolism obtained from control subjects or the patients with hyperuricemia, gout or type 2 diabetes.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University.
authors.forename: M
authors.initials: M
authors.lastname: Iwatani
authors.forename: T
authors.initials: T
authors.lastname: Wasada
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: N
authors.initials: N
authors.lastname: Kamatani
mesh_terms: D002839:Chromans / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006073:Gout / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D006949:Hyperlipidemias; D006973:Hypertension; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007333:Insulin Resistance; D008297:Male; D009765:Obesity; D013577:Syndrome; D013844:Thiazoles / Q000627:therapeutic use*; D045162:Thiazolidinediones; D000077288:Troglitazone; D014527:Uric Acid / Q000097:blood*
chemical_list: D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D014527:Uric Acid; D000077288:Troglitazone; D005947:Glucose