[The combined use of fentanyl and clofelin in the anesthesiological support of adrenalectomy].
The analgetic effect of a combination of phentanyl and clonidine was investigated in 68 cases of adrenalectomy as an analgetic component of anesthesia. The analgesic potency of the used combination and stability of the autonomous functions were proved to be sufficient in surgical interventions for various types of adrenal tumors. It was found that the mechanism of the clonidine effect was not associated with vasodilatation and was based on its antinociceptive properties. The role of hemodynamic monitoring in prevention of possible complications and adverse effects of the described anesthetic technique was stressed.
Zakharov
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DA
Lebedinskiĭ
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D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000503:physiopathology / Q000601:surgery; D000315:Adrenalectomy / Q000379:methods*; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D019162:Anesthetics, Combined / Q000008:administration & dosage / Q000009:adverse effects; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged
D000700:Analgesics; D000701:Analgesics, Opioid; D019162:Anesthetics, Combined; D003000:Clonidine; D005283:Fentanyl