title: Exposure and allergic sensitization to cockroach allergen in East Germany.
abstract: BACKGROUND
  Some studies suggest that the prevalence of sensitization to cockroach allergens may be higher in the United States than in Europe, but there are no comparable data from population-based studies.
  
  
  OBJECTIVE
  To determine the prevalence of allergic sensitization to German cockroach (GCR) in German schoolchildren and to assess its clinical relevance; and to determine the exposure to the major GCR allergen Bla g 2 in non-selected homes and nurseries.
  
  
  METHODS
  The prevalence of allergic sensitization to GCR and other allergens was determined by measurement of specific IgE and skin-prick tests in a cross-sectional study of 2993 children aged 5-11 years in Dresden, Germany. The prevalence of atopic disease was determined by questionnaire, and pulmonary function and bronchial hyperresponsiveness to hypertonic saline were measured. Bla g 2 exposure was determined on floors of 187 kitchens and 47 nurseries by a commercial sandwich ELISA.
  
  
  RESULTS
  One hundred and twenty-seven (4.2%) of the children had specific IgE (> 0.7 kU/L) against GCR. Among children with current wheeze, 8.4% were GCR-sensitized. Compared to data from the United States, the prevalence of sensitization to cockroach was similar in children without asthma (3.9%), but less frequent in asthmatic children from Dresden (6.1%). After adjustment for positive reactions to other allergens (SX1 test) no significant impact of GCR sensitization on wheeze or other symptoms and diagnoses was found. Bla g 2 was detected in 29% of the kitchens and 43% of the nurseries. None of these sites had exposure levels above the proposed threshold for causing disease of 80 ng/g dust.
  
  
  CONCLUSIONS
  The data suggest that allergic sensitization to GCR is less frequent in asthmatics from Dresden, Germany than in US cities. The data indicate that GCR sensitization is not an independent risk factor for asthma and other atopic diseases in 5-11-year-olds from this city.
authors.affiliation: University Children's Hospital Dresden, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Hirsch
authors.forename: C
authors.initials: C
authors.lastname: Stappenbeck
authors.forename: V
authors.initials: V
authors.lastname: Neumeister
authors.forename: S K
authors.initials: SK
authors.lastname: Weiland
authors.forename: E
authors.initials: E
authors.lastname: Von Mutius
authors.forename: U
authors.initials: U
authors.lastname: Keil
authors.forename: W
authors.initials: W
authors.lastname: Leupold
mesh_terms: D000485:Allergens; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003058:Cockroaches; D003430:Cross-Sectional Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D015995:Prevalence
chemical_list: D000485:Allergens; D016282:Aspartic Acid Endopeptidases; C094699:allergen Bla g 2