Sensitivity analysis of pharmacokinetic parameters in one-compartment models.
The quantitative properties of a compartmental model can be characterized by the pharmacokinetic parameters. The sensitivity analysis of pharmacokinetic parameters was studied in six kinds of one-compartment models. The sensitivity functions with respect to different pharmacokinetic parameters for these one-compartment models were deduced using the partial differentiation. The pharmacokinetic parameters were ranked according to their sensitivity functions.
Wu
G
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Service of Clinical Pharmacology and Toxicology, Chair of Special Pharmacology, Medical School, University of Udine, P.le S. Maria della Misericordia, Udine, 33100, Italy.
D000465:Algorithms; D019540:Area Under Curve; D003627:Data Interpretation, Statistical; D008954:Models, Biological; D010599:Pharmacokinetics