title: An efficient one-pot method for the large-quantitative production of radiopharmaceutical ligand: diazadioximes.
abstract: An efficient one-pot procedure for the preparation of diazadioxime was described. Treatment of ketooximes with alkyldiamine followed by NaBH4 in dry ethanol afforded the corresponding d,l-diazadioximes in 56--74% yield without isolation of the intermediates.
authors.affiliation: Department of Nuclear Medicine, School of Technology for Medical Sciences, Kaohsiung Medical University, Taiwan, R.O.C.
authors.forename: H J
authors.initials: HJ
authors.lastname: Ding
authors.forename: Y F
authors.initials: YF
authors.lastname: Huang
authors.forename: C C
authors.initials: CC
authors.lastname: Tzeng
authors.forename: S J
authors.initials: SJ
authors.lastname: Yeh
authors.forename: L L
authors.initials: LL
authors.lastname: Wei
mesh_terms: D003959:Diamines / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010091:Oximes / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
chemical_list: D003959:Diamines; D007202:Indicators and Reagents; D008024:Ligands; D010091:Oximes; D019275:Radiopharmaceuticals