In vitro evaluation study of the membrane autotransfusion system experimental prototype: MATS-I.
Membrane Autotransfusion System (MATS) utilizing plasmapheresis technology has been developed in our laboratory. A specially designed polyethylene hollow fiber membrane was utilized. This study was conducted to evaluate performance of the first experimental prototype, MATS-I. The results of this study showed that the MATS-I could concentrate diluted blood at 10% of the initial hematocrit concentration (HCTi) into over 40% after passing through the system at a transmembrane pressure of 70 mm Hg. Moreover, the MATS-I can continuously treat 10,000 ml of diluted blood at various HCTi levels without deteriorating its performances. Even though the MATS-I met all required performances as an autotransfusion system, several areas of improvement of the system were necessary to meet various clinical needs. The next prototype, MATS-II, can be designed based on experiences obtained from the MATS-I. The MATS is smaller, more atraumatic and continuous, and is a faster system when compared to the currently available centrifugal autotransfusion devices.
Fukunaga
K
K
Department of Internal Medicine IV, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Shimoyama
T
T
Sawada
K
K
Mueller
J
J
Sueoka
A
A
Nosé
Y
Y
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001804:Blood Transfusion, Autologous / Q000295:instrumentation / Q000379:methods; D002417:Cattle; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D005240:Feasibility Studies; D006400:Hematocrit; D006440:Hemofiltration / Q000295:instrumentation; D008567:Membranes, Artificial; D008838:Microcomputers; D010956:Plasmapheresis; D020959:Polyethylene / Q000737:chemistry; D011312:Pressure; D013813:Therapy, Computer-Assisted; D013997:Time Factors
D001672:Biocompatible Materials; D008567:Membranes, Artificial; D020959:Polyethylene