Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine.
The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.
Tamiz
A P
AP
Drug Discovery Program, Institute of Cognitive and Comuputational Science, Georgetown University Medical Center, Washington, DC 20007-2197, USA.
Smith
M P
MP
Kozikowski
A P
AP
D002460:Cell Line; D003042:Cocaine / Q000737:chemistry*; D015195:Drug Design; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D006575:Heterocyclic Compounds, 3-Ring; D003042:Cocaine