Growth hormone treatment of patients with Prader-Willi syndrome. Swedish Growth Hormone Advisory Group.
Several studies have now been published on the effect of one or several years of growth hormone treatment on growth and body composition of children with Prader-Willi syndrome. The majority of the patients have responded with greatly increased growth rate, decreased body fat and increased muscle volume. Many of these children seem to have a functional growth hormone deficiency, probably secondary to their hypothalamic dysfunction. Further studies are needed to establish the long-term effect of this treatment on somatic and psychological well-being.
Ritzén
E M
EM
Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden.
Lindgren
A C
AC
Hagenäs
L
L
Marcus
C
C
Müller
J
J
Blichfeldt
S
S
D001823:Body Composition / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D020249:Hormone Replacement Therapy / Q000009:adverse effects / Q000523:psychology; D019382:Human Growth Hormone / Q000009:adverse effects / Q000172:deficiency / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000188:drug therapy; D007040:Hypoventilation / Q000150:complications / Q000188:drug therapy; D011218:Prader-Willi Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology
D019382:Human Growth Hormone