The -323Ins10 polymorphism for factor VII is not associated with coronary atherosclerosis in symptomatic men. The REGRESS study group.
Elevated factor VII coagulant activity (FVII:C) has been associated with an increased risk of ischaemic heart disease, particularly for fatal events. Results of studies on the association between FVII:C and atherosclerosis are not consistent. FVII:C levels are influenced by several environmental factors and by genetic factors. One of the genetic factors is the -323Ins10 polymorphism in the promoter region of the factor VII gene, which is strongly related to FVII:C, and thus may be associated with ischaemic heart disease. We studied the association of this polymorphism with the severity and progression of atherosclerosis. In 511 male patients of the Regression Growth Evaluation Statin Study, the genotype for the -323Ins10 polymorphism was determined. The minimum obstruction diameter and the mean segment diameter were determined at baseline and after a 2-year follow-up period, and new lesion formation was assessed as well. Cardiovascular events were recorded. No relationship was observed between the -323Ins10 polymorphism and angiographic measures of disease progression, nor on the risk of new cardiovascular events. The results suggest that there is no association between the -323Ins10 polymorphism for factor VII and the severity or progression of coronary atherosclerosis in male patients with symptomatic coronary artery disease.
Lievers
K J
KJ
Department of Human Nutrition and Epidemiology, Agricultural University, Wageningen, The Netherlands.
Mennen
L I
LI
Rattink
A P
AP
Zwinderman
A H
AH
Jukema
J W
JW
Schouten
E G
EG
de Maat
M P
MP
D000328:Adult; D000368:Aged; D003029:Coagulants / Q000009:adverse effects; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000209:etiology / Q000235:genetics*; D018450:Disease Progression; D005167:Factor VII / Q000009:adverse effects / Q000235:genetics*; D016368:Frameshift Mutation / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic; D012307:Risk Factors
D003029:Coagulants; D005167:Factor VII