title: Cognitive-behavioral stress management intervention effects on anxiety, 24-hr urinary norepinephrine output, and T-cytotoxic/suppressor cells over time among symptomatic HIV-infected gay men.
abstract: The present study tested the effects of a multimodal cognitive-behavioral stress management (CBSM) intervention on anxious mood, perceived stress, 24-hr urinary catecholamine levels, and changes in T-lymphocyte subpopulations over time in symptomatic HIV+ gay men. Seventy-three men were randomized to either a group-based CBSM intervention (n = 47) or a wait-list control (WLC) condition (n = 26). Men assigned to CBSM showed significantly lower posttreatment levels of self-reported anxiety, anger, total mood disturbance, and perceived stress and less norepinephrine (NE) output as compared with men in the WLC group. At the individual level, anxiety decreases paralleled NE reductions. Significantly greater numbers of T-cytotoxic/suppressor (CD3+CD8+) lymphocytes were found 6 to 12 months later in those assigned to CBSM. Moreover, greater decreases in NE output and a greater frequency of relaxation home practice during the 10-week CBSM intervention period predicted higher CD3+CD8+ cell counts at follow-up.
authors.affiliation: Department of Psychology, University of Miami, Coral Gables, Florida 33124, USA. MAntoni@umiami.ir.miami.edu
authors.forename: M H
authors.initials: MH
authors.lastname: Antoni
authors.forename: D G
authors.initials: DG
authors.lastname: Cruess
authors.forename: S
authors.initials: S
authors.lastname: Cruess
authors.forename: S
authors.initials: S
authors.lastname: Lutgendorf
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: G
authors.initials: G
authors.lastname: Ironson
authors.forename: N
authors.initials: N
authors.lastname: Klimas
authors.forename: M A
authors.initials: MA
authors.lastname: Fletcher
authors.forename: N
authors.initials: N
authors.lastname: Schneiderman
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D001008:Anxiety Disorders / Q000276:immunology / Q000523:psychology / Q000628:therapy*; D017252:CD3 Complex / Q000097:blood; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015928:Cognitive Behavioral Therapy; D015658:HIV Infections / Q000276:immunology* / Q000523:psychology; D018451:Homosexuality, Male / Q000523:psychology*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D009638:Norepinephrine / Q000652:urine*; D010555:Personality Inventory; D011598:Psychoneuroimmunology; D013315:Stress, Psychological / Q000150:complications*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D017252:CD3 Complex; D009638:Norepinephrine