title: Changes in the rCBF images of patients with Alzheimer's disease receiving Donepezil therapy.
abstract: Alzheimer's disease is associated with a loss in presynaptic cholinergic function. It has been suggested that cholinergic inhibitors such as donepezil hydrochloride (Donepezil) could restore this function and improve some of the symptoms of Alzheimer's disease. Previous work has shown that Donepezil improves cognitive and global function in patients with mild to moderate Alzheimer's disease. This study reviewed retrospectively 12 patients who had previously had a 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) single photon emission tomography (SPET) regional cerebral blood flow (rCBF) examination and had gone on to receive Donepezil therapy. These patients were recalled for a further 99Tcm-HMPAO SPET rCBF examination and the image data sets were compared. The results showed an overall increase in global cerebral blood flow (P = 0.04) averaged over the group with a percentage change in blood flow ranging from -1.8% to 6.4%. However, some patients showed a slight decrease in blood flow. When the data were analysed in terms of regional cerebral blood flow, we found that the most significant increase in blood flow occurred in the frontal lobes (P = 0.02).
authors.affiliation: Department of Bio-Medical Physics, University of Aberdeen, UK. r.staff@biomed.abdn.ac.uk
authors.forename: R T
authors.initials: RT
authors.lastname: Staff
authors.forename: H G
authors.initials: HG
authors.lastname: Gemmell
authors.forename: M F
authors.initials: MF
authors.lastname: Shanks
authors.forename: A D
authors.initials: AD
authors.lastname: Murray
authors.forename: A
authors.initials: A
authors.lastname: Venneri
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D000077265:Donepezil; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007189:Indans / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007189:Indans; D018697:Nootropic Agents; D010880:Piperidines; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D000077265:Donepezil