Long term survival of a patient with malignant pleural mesothelioma as a late complication of radiotherapy for Hodgkin's disease treated with 90yttrium-silicate.
A case of malignant pleural mesothelioma (PM) 24 years after thoracic radiotherapy for Hodgkin's disease is presented. As primary treatment and to relieve symptoms of dyspnea secondary to pleural effusion a thoracic drain was installed, followed by intracavitary radiation therapy with 90yttrium-silicate. Minor complaints of fever and a dry cough as a side-effect of this treatment were effectively treated with prednisone during 2 weeks. The patient remains in a good clinical condition now 6 years after diagnosis. Considering the few therapeutic options the use of 90yttrium-silicate intrapleural installation could be propagated as a safe and effective antitumour treatment for a selected group of patients with malignant PM.
Kramer
G
G
ARTI, Joint Centre for Radiotherapy Arnhem-Nijmegen, Wagnerlaan 47, 6815 AD, Arnhem, The Netherlands. gkramer@radian.nl
Gans
S
S
Rijnders
A
A
Leer
J
J
D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000209:etiology*; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010997:Pleural Neoplasms / Q000209:etiology*; D017741:Survivors; D015021:Yttrium Radioisotopes / Q000009:adverse effects
D015021:Yttrium Radioisotopes