title: Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity.
abstract: The thermogenic effect of tea is generally attributed to its caffeine content. We report here that a green tea extract stimulates brown adipose tissue thermogenesis to an extent which is much greater than can be attributed to its caffeine content per se, and that its thermogenic properties could reside primarily in an interaction between its high content in catechin-polyphenols and caffeine with sympathetically released noradrenaline (NA). Since catechin-polyphenols are known to be capable of inhibiting catechol-O-methyl-transferase (the enzyme that degrades NA), and caffeine to inhibit trancellular phosphodiesterases (enzymes that break down NA-induced cAMP), it is proposed that the green tea extract, via its catechin-polyphenols and caffeine, is effective in stimulating thermogenesis by relieving inhibition at different control points along the NA-cAMP axis. Such a synergistic interaction between catechin-polyphenols and caffeine to augment and prolong sympathetic stimulation of thermogenesis could be of value in assisting the management of obesity. International Journal of Obesity (2000) 24, 252-258
authors.affiliation: Institute of Physiology, University of Fribourg, Fribourg, Switzerland. abdul.dulloo@unifr.ch
authors.forename: A G
authors.initials: AG
authors.lastname: Dulloo
authors.forename: J
authors.initials: J
authors.lastname: Seydoux
authors.forename: L
authors.initials: L
authors.lastname: Girardier
authors.forename: P
authors.initials: P
authors.lastname: Chantre
authors.forename: J
authors.initials: J
authors.lastname: Vandermander
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D046508:Culture Techniques; D004809:Ephedrine / Q000494:pharmacology; D005419:Flavonoids; D041743:Herb-Drug Interactions; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D010101:Oxygen Consumption; D010636:Phenols / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013662:Tea
chemical_list: D000697:Central Nervous System Stimulants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D011108:Polymers; D013662:Tea; D002110:Caffeine; D002392:Catechin; D004809:Ephedrine; D009638:Norepinephrine