title: Effect of acute moderate changes in PaCO2 on global hemodynamics and gastric perfusion.
abstract: OBJECTIVE
  To describe global hemodynamics and splanchnic perfusion changes in response to acute modifications in Paco2 in hemodynamically stable patients.
  
  
  METHODS
  Prospective, randomized crossover study.
  
  
  METHODS
  Medical-surgical intensive care unit at a community hospital (400,000 inhabitants).
  
  
  METHODS
  Ten critically ill patients who were sedated, paralyzed, and mechanically ventilated.
  
  
  METHODS
  Hypercapnia and hypocapnia were obtained by increasing and reducing instrumental deadspace in random order. After each intervention, patients returned to the basal condition. Each period lasted 80 min: 20 min to achieve stable Paco2 and 60 min for tonometer equilibration. In each period, global hemodynamic variables and tonometric data were collected. The periods were compared using analysis of variance.
  
  
  RESULTS
  Acute hypercapnia (Paco2 from 40+/-3 to 52+/-3 torr, p<.05) increased cardiac index (3.43+/-0.37 vs. 3.97+/-0.43 mL/min/m2, p<.05), heart rate (95+/-6 vs. 105+/-3 beats/min, p<.05), and mean pulmonary artery pressure (21+/-1 vs. 24+/-1 mm Hg, p<.05) and reduced systemic vascular resistance (992+/-98 vs. 813+/-93 dyne x sec/ cm5, p<.05) and oxygen extraction ratio (27+/-3% vs. 22+/-2%, p<.05). Standardized intramucosal Pco2 increased from 49+/-2 to 61+/-3 torr (p<.05) with an associated decrease in calculated intramucosal pH ([pHi] 7.35+/-0.03 vs. 7.25+/-0.02, p<.05), but the gastro-arterial Pco2 gradient (deltaPco2) did not change. Acute hypocapnia (Paco2 from 41+/-3 to 34+/-3 torr, p<.05; pH 7.41+/-0.01 to 7.47+/-0.02, p<.05) induced slight increments in systemic vascular resistance (995+/-117 vs. 1088 +/- 160 dyne x sec/cm5, p<.05) and oxygen extraction ratio (28+/-2% vs. 30+/-2%, p<.05). Standardized intramucosal Pco2 decreased (50+/-4 vs. 44+/-3 torr, p<.05), pHi increased (7.33+/-0.03 vs. 7.36+/-0.02; p<.05), but deltaPco2 did not change.
  
  
  CONCLUSIONS
  In this small group of stable patients, moderate acute variations in Paco2 had a significant effect on global hemodynamics, but splanchnic perfusion, assessed by deltaPco2, did not change. In these conditions, the use of pHi to evaluate gastric perfusion appears unreliable.
authors.affiliation: Intensive Care Services, Corporació Sanitaria Parc Taulí, Sabadell, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Mas
authors.forename: P
authors.initials: P
authors.lastname: Saura
authors.forename: D
authors.initials: D
authors.lastname: Joseph
authors.forename: L
authors.initials: L
authors.lastname: Blanch
authors.forename: F
authors.initials: F
authors.lastname: Baigorri
authors.forename: A
authors.initials: A
authors.lastname: Artigas
authors.forename: R
authors.initials: R
authors.lastname: Fernández
mesh_terms: D000208:Acute Disease; D000368:Aged; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood*; D018592:Cross-Over Studies; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply*; D006439:Hemodynamics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*; D016857:Hypocapnia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D011446:Prospective Studies; D015203:Reproducibility of Results; D012121:Respiration, Artificial / Q000009:adverse effects; D012126:Respiratory Dead Space; D013152:Splanchnic Circulation; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide