title: GTR with bioresorbable membranes in the treatment of intrabony defects: a clinical and histologic study.
abstract: The aim of the present study was to evaluate clinically and histologically the treatment of intrabony periodontal defects with a bioresorbable membrane barrier. Fifty-two intrabony periodontal defects were treated according to the principles of guided tissue regeneration (GTR) with a bioresorbable membrane. Results were evaluated by assessing probing pocket depth, recession of the gingival margin, and clinical attachment level at baseline and at 1 and 2 years after therapy. Bone level changes were evaluated radiographically. The postoperative phase was uneventful in all cases. There was a mean probing pocket depth reduction from 8.4 to 3.6 mm, a mean increase of gingival margin recession from 1.5 to 3.0 mm, and a mean clinical attachment level change from 9.9 to 6.5 mm. Mean attachment gain was 3.4 mm. Two teeth scheduled for extraction were also treated with the same bioresorbable membrane. The histologic analysis 6 months after treatment revealed the formation of new connective tissue attachment and new alveolar bone in both cases. Based on the histologic findings it can be concluded that the clinical improvements following GTR with this type of bioresorbable membrane may represent, at least in part, true periodontal regeneration.
authors.affiliation: Department of Periodontology and Conservative Dentistry, University of the Saarland, Homburg, Germany. zmkascu@med-rz.uni-sb.de
authors.forename: A
authors.initials: A
authors.lastname: Sculean
authors.forename: N
authors.initials: N
authors.lastname: Donos
authors.forename: G C
authors.initials: GC
authors.lastname: Chiantella
authors.forename: P
authors.initials: P
authors.lastname: Windisch
authors.forename: E
authors.initials: E
authors.lastname: Reich
authors.forename: M
authors.initials: M
authors.lastname: Brecx
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D001672:Biocompatible Materials; D001861:Bone Regeneration; D003739:Dental Cementum / Q000502:physiology; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D011098:Polyglactin 910; D012038:Regeneration; D018709:Statistics, Nonparametric
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; C094810:Resolut; D011098:Polyglactin 910