title: Spatial and temporal stability of mtDNA haplogroup frequencies in native North America.
abstract: Mitochondrial DNA lineage frequencies in prehistoric Aleut, eastern Utah Fremont, Southwestern Anasazi, Pyramid Lake, and Stillwater Marsh skeletal samples from northwest Nevada and the Oneota of western Illinois are compared with those in 41 contemporary aboriginal populations of North America. The ancient samples range in age from 300 years to over 6,000 years. The results indicate that the prehistoric inhabitants of North America exhibit the same level of mtDNA variability as contemporary populations of the continent. Variation in modern mtDNA haplogroup frequencies is highly geographically structured, and the prehistoric samples exhibit the same geographic pattern of variation. This indicates that differentiation of regional patterns of mtDNA lineage variation occurred early in North American prehistory (much more than 2,000 years B.P.), has remained relatively stable since its origin, and was little influenced by the disruptions hypothesized for other genetic systems as a result of population declines and relocations at contact.
authors.affiliation: Laboratory of Biological Anthropology, University of Utah, Salt Lake City 84112, USA.
authors.forename: D H
authors.initials: DH
authors.lastname: O'Rourke
authors.forename: M G
authors.initials: MG
authors.lastname: Hayes
authors.forename: S W
authors.initials: SW
authors.lastname: Carlyle
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D004641:Emigration and Immigration / Q000706:statistics & numerical data / Q000639:trends; D005163:Factor Analysis, Statistical; D005787:Gene Frequency / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D009656:North America; D010163:Paleontology; D011110:Polymorphism, Genetic / Q000235:genetics; D044469:Racial Groups; D012111:Residence Characteristics / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: D004272:DNA, Mitochondrial; D005819:Genetic Markers