title: Genetics in the study of mosquito susceptibility to Plasmodium.
abstract: Within the past several years, a number of powerful genetic and genomic tools have been developed for use in research on the African malaria vector Anopheles gambiae. While these tools have been developed with a broad range of potential applications in mind, they have been particularly useful in advancing the effort to clone a set of An. gambiae genes that enable a refractory strain of this mosquito to encapsulate and kill a wide variety of different malaria parasites to which this mosquito is normally fully susceptible. This paper describes the latest progress in this map-based cloning research, which involves the collaborative contributions of a number of different laboratories in Europe and the United States.
authors.affiliation: Department of Biological Sciences, University of Notre Dame, IN 46556, USA. frank.h.collins.75@nd.edu
authors.forename: F H
authors.initials: FH
authors.lastname: Collins
authors.forename: R D
authors.initials: RD
authors.lastname: Saunders
authors.forename: F C
authors.initials: FC
authors.lastname: Kafatos
authors.forename: C
authors.initials: C
authors.lastname: Roth
authors.forename: Z
authors.initials: Z
authors.lastname: Ke
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Dymbrowski
authors.forename: L
authors.initials: L
authors.lastname: Ton
authors.forename: J
authors.initials: J
authors.lastname: Hogan
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics / Q000469:parasitology*; D003001:Cloning, Molecular; D004198:Disease Susceptibility; D007303:Insect Vectors; D010961:Plasmodium / Q000235:genetics / Q000472:pathogenicity*