The treatment with alendronate in hemifacial spasm associated with Paget's disease of bone.
The association of Paget's disease of bone and hemifacial spasm has rarely been reported. Hemifacial spasm is often associated with compression of the facial nerve by a vascular loop at the point where the nerve leaves the brainstem before traversing the cerebellopontine angle. It is believed that narrowing of the cerebellopontine angle cistern caused by Paget's disease increases the chance of vascular compression of the facial nerve. Whilst specific antipagetic therapy such as calcitonin has been used with good response in hemifacial spasm associated with Paget's disease, the usefulness of the newer bisphosphonates is not clear. A 65-year-old woman with hemifacial spasm associated with Paget's disease was treated with alendronate, and the hemifacial spasm became very infrequent 4 months after commencement of the therapy.
Fu
K K
KK
Department of Medicine, The University of, Hong Kong, Hong Kong.
Ko
A
A
D000368:Aged; D019386:Alendronate / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D005071:Evoked Potentials / Q000502:physiology; D005152:Facial Muscles / Q000503:physiopathology; D005260:Female; D019569:Hemifacial Spasm / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D010001:Osteitis Deformans / Q000150:complications* / Q000188:drug therapy*
D019386:Alendronate