Isolation of a new potent cytotoxic pigment along with indigotin from the pathogenic basidiomycetous fungus Schizophyllum commune.
An indole derivative, schizocommunin, was isolated along with indigotin (indigo), indirubin, isatin, and tryptanthrin, from the liquid culture medium in which a culture of Schizophyllum commune, isolated from the bronchus of a human patient with allergic bronchopulmonary mycosis, had been grown. The structure of schizocommunin was established by spectroscopic investigation. Schizocommunin showed the strong cytotoxicity against murine lymphoma cells. The assignments of the 1H- and 13C-NMR signals of indigotin were also listed.
Hosoe
T
T
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Nozawa
K
K
Kawahara
N
N
Fukushima
K
K
Nishimura
K
K
Miyaji
M
M
Kawai
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D007203:Indigo Carmine; D007211:Indoles / Q000302:isolation & purification* / Q000633:toxicity; D008223:Lymphoma; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010860:Pigments, Biological / Q000302:isolation & purification; D012567:Schizophyllum / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007211:Indoles; D010860:Pigments, Biological; C405922:schizocommunin; D007203:Indigo Carmine