title: Open Nissen fundoplication and highly selective vagotomy as a treatment for gastro-oesophageal reflux disease.
abstract: BACKGROUND
  Open Nissen fundoplication has been the most common surgical treatment of gastro-oesophageal reflux disease (GORD). The present paper describes the symptomatic result, and quantifies the acid reduction achieved by open Nissen fundoplication combined with highly selective vagotomy (HSV) in a consecutive case series.
  
  
  METHODS
  A study of 106 patients undergoing open Nissen fundoplication and HSV for GORD was performed between 1988 and 1996. A history consistent with reflux was obtained and the diagnosis confirmed with ambulatory oesophageal pH studies and endoscopy. Postoperative pH studies were performed, and peri-operative and late complications were recorded. A standard questionnaire was sent out to patients postoperatively to assess the efficacy of surgery.
  
  
  RESULTS
  Pre-operative pH studies were performed on 104 (98%) patients, and on 97 (91.5%) following surgery. There was a highly significant improvement in all parameters of the pH study postoperatively. All symptoms, including bloating and dysphagia, improved significantly postoperatively, except flatulence, which was exacerbated. The majority of patients were very satisfied with their outcome, 82% rating the operation from 80 to 100% successful. Complications were rare and there was no mortality.
  
  
  CONCLUSIONS
  Open Nissen fundoplication and HSV is an effective method of treating GORD, producing an improvement in symptoms and in ambulatory pH studies.
authors.affiliation: Department of Surgery, Christchurch Hospital, New Zealand.
authors.forename: R D
authors.initials: RD
authors.lastname: Bohmer
authors.forename: R H
authors.initials: RH
authors.lastname: Roberts
authors.forename: R J
authors.initials: RJ
authors.lastname: Utley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004947:Esophagus / Q000378:metabolism; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D014629:Vagotomy, Proximal Gastric