Influence of exposure to new circumstances on pharmacokinetics of plasma drugs concentrations in rats.
The influences of emotional changes induced by being exposed to a new environment on the pharmacokinetics of plasma drug concentration were studied in male Wistar rats. Transfer from a familiar home cage to a new home cage was considered to induce psychological (non-physical) emotional changes. First, nicorandil and zonisamide, drugs that act on the peripheral system and central nervous systems, were used, respectively. Immediately after oral administration of nicorandil (10 mg/kg) or zonisamide (50 mg/kg), the animals were transferred to new home cages. Plasma nicorandil and zonisamide concentrations were determined by high-performance liquid chromatography at 1 and 4 h after administration. Plasma nicorandil concentration in the group transferred to new home cages was significantly decreased relative to levels in the non-transferred control group. However, zonisamide concentrations were unchanged. These findings suggest that the pharmacokinetics of nicorandil, but not those of zonisamide, tend to be influenced by non-physically induced emotional changes.
Hashimoto
Y
Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Kawasaki
H
H
Gomita
Y
Y
D000818:Animals; D007555:Isoxazoles / Q000493:pharmacokinetics*; D008297:Male; D020108:Nicorandil / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism*; D000078305:Zonisamide
D007555:Isoxazoles; D020108:Nicorandil; D000078305:Zonisamide