Increased levels of circulating ICAM-1, E-selectin, and IL-2 receptors in celiac disease.
Adhesive interactions between endothelium and circulating cells are crucial for the development of inflammatory reactions. We found significantly higher serum levels of soluble intracellular adhesion molecule-1 (sICAM-1, 492.5 +/- 22.1 ng/ml) in patients with active celiac disease (including IgA-deficient patients) than in patients on a gluten-free diet (335.7 +/- 20.0 ng/ml) (P < 0.001) and healthy controls (207.4 +/- 11.2 ng/ml) (P < 0.001). The concentration of soluble E-selectin in sera from celiac patients (37.2 +/- 3.4 ng/ml) was also higher (P < 0.001) than in sera from healthy controls (15.5 +/- 0.7 ng/ml) but, in contrast to sICAM-1, it remained high in the patients after treatment (30.2 +/- 2.7 ng/ml). Interestingly, the concentration of circulating soluble interleukin-2 receptors, molecules indicating lymphocyte activation, was only increased in sera from patients with active celiac disease (2943.0 +/- 214.1 pg/ml), and the level in sera from treated patients and healthy controls was comparable (1936 +/- 349 and 1416 +/- 111.7 pg/ml). The elevated serum level of soluble cell adhesion molecules could be used as a supplementary, noninvasive procedure for monitoring intestinal immune reactions.
Jelínková
L
L
Department of Immunology, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic.
Tucková
L
L
Sánchez
D
D
Krupicková
S
S
Pozler
O
O
Nevoral
J
J
Kotalová
R
R
Tlaskalová-Hogenová
H
H
D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000097:blood* / Q000178:diet therapy; D002648:Child; D002675:Child, Preschool; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood*
D019040:E-Selectin; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1