[Nucleolar organizers and mitotic conditions in endometrial hyperplasia and carcinomaĭ].
The study deals with the levels of nucleolar organizers (NO) and mitotic conditions in 85 samples of the endometrium (proliferative stage of menstrual cycle--5; glandular hyperplasia--10; adenomatosis--15; atypical hyperplasia--25 and adenocarcinoma--25). These findings point to a significant increase in NO number in atypical hyperplasia and especially in adenocarcinoma. The latter showed an inverse correlation between the index under study and cell differentiation stage. Endometrial mitosis displayed a higher mitotic index, a larger fraction of pathological mitoses and cells passing through metaphase as well as a variety of pathological forms of karyokinesis. A high correlation between NO number and mitotic index was observed for different conditions of the endometrium.
Ellinidi
V N
VN
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Pozharisskii
K M
KM
D000230:Adenocarcinoma / Q000503:physiopathology* / Q000648:ultrastructure; D000328:Adult; D000368:Aged; D004714:Endometrial Hyperplasia / Q000473:pathology / Q000503:physiopathology*; D016889:Endometrial Neoplasms / Q000503:physiopathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008875:Middle Aged; D008938:Mitosis; D008940:Mitotic Index; D009697:Nucleolus Organizer Region