Anticoagulative effect of pepsin.
Anticoagulative effect of pepsin is observed in vitro when its concentration is 36 microM and higher. This effect is due to inhibition of fibrin monomer polymerization. Protamine abolishes anticoagulative effect of pepsin. Pepsin does not influence platelet aggregation induced by ADP and collagen.
Gacko
M
M
Department of Instrumental Analysis, Medical Academy, Białystok, Poland.
Roszkowska-Jakimiec
W
W
Jasielczuk
J
J
D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D010434:Pepsin A / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011479:Protamines / Q000494:pharmacology; D011517:Prothrombin Time; D013918:Thrombin Time
D000925:Anticoagulants; D011479:Protamines; D010434:Pepsin A