Gap junctional intercellular communication and carcinogenesis.
Intercellular communications are indispensable for the maintenance of homeostasis in the multicellular organisms. Gap-type junctions are one of the most common and perhaps most interesting intercellular connections. Of various communication systems gap junctional intercellular communication is the only means for cells to directly exchange signals. Substantial progress has recently been made in the studies on the role of gap junctions both in experimental and human tumorigenesis. The present study is a review of the potential mechanisms associated with gap junctional cellular communication included in non-genotoxic tumorigenesis.
Sulkowski
S
S
Sulkowska
M
M
Skrzydlewska
E
E
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology*; D017630:Connexins / Q000737:chemistry / Q000502:physiology; D017629:Gap Junctions / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000648:ultrastructure
D015815:Cell Adhesion Molecules; D017630:Connexins