title: Prenatally diagnosed sacrococcygeal teratoma: a unique expression of trisomy 1q.
abstract: Partial duplication of the long arm of chromosome 1 has been observed in fetal intracranial teratomas. We sonographically diagnosed a 19-week fetus with sacrococcygeal teratoma, cerebral ventriculomegaly, and cerebellar hypoplasia. Chromosomal analysis of amniocytes showed an unbalanced translocation between chromosomes 1 and 15, resulting in trisomy 1q21-->1 qter. Duplication or over expression at more than one locus on the long arm of chromosome 1 may be required for the development of an extra-gonadal teratoma.
authors.affiliation: Department of Obstetrics and Gynecology, Hartford Hospital, Connecticut 06102-5037, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Wax
authors.forename: P
authors.initials: P
authors.lastname: Benn
authors.forename: J D
authors.initials: JD
authors.lastname: Steinfeld
authors.forename: C J
authors.initials: CJ
authors.lastname: Ingardia
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D012445:Sacrococcygeal Region / Q000473:pathology*; D013724:Teratoma / Q000000981:diagnostic imaging* / Q000235:genetics; D016216:Ultrasonography, Prenatal