title: Effect of olprinone, phosphodiesterase III inhibitor, on cerebral blood flow assessed with technetium-99m-ECD SPECT.
abstract: Few clinical reports exist regarding the effects of phosphodiesterase III inhibitors on cerebral arteries. Therefore we used a [99mTc]-ECD brain SPECT and an ultrasound method to quantitatively evaluate cerebral and systemic flow dynamics after the administration of olprinone, a phosphodiesterase III inhibitor. In 15 patients (65 +/- 8 years, M/F = 13/2) with no abnormalities on a brain computed tomography (CT), cerebral blood flow and cardiac output were measured using [99mTc]-ECD brain SPECT and Doppler echocardiography, respectively. Measurements were repeated at baseline and after the administration of olprinone. Significant increases in cerebral blood flow (p = 0.0007) and cardiac output (p = 0.001) were observed, and systolic blood pressure (p = 0.02) and systemic vascular resistance (p = 0.002) significantly decreased. No significant correlation between the increase in cerebral blood flow and the increase in cardiac output was observed. The data indicate that olprinone has a direct vasodilator effect on the cerebral artery, which was little related to the increase in cardiac output in patients who had not experienced stroke.
authors.affiliation: Second Department of Internal Medicine, Kagawa Medical University, Kita Kagawa, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: K
authors.initials: K
authors.lastname: Mizushige
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: M
authors.initials: M
authors.lastname: Seki
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.forename: M
authors.initials: M
authors.lastname: Ohkawa
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003545:Cysteine / Q000031:analogs & derivatives; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D016014:Linear Models; D008297:Male; D015609:Organotechnetium Compounds; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology*; D019275:Radiopharmaceuticals
chemical_list: D007093:Imidazoles; D015609:Organotechnetium Compounds; D010726:Phosphodiesterase Inhibitors; D011728:Pyridones; D019275:Radiopharmaceuticals; C059498:olprinone; C059659:technetium Tc 99m bicisate; D003545:Cysteine