title: Successful eradication of Helicobacter pylori as determined by ((13))C-urea breath test does not alter fibrinogen and acute phase response markers.
abstract: In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successful eradication proven by the 13C-urea breath test does not alter acute phase response markers. These findings indicate that Helicobacter pylori infection is unlikely to affect atherosclerosis unfavourably via acute phase response.
authors.affiliation: ISOTOPIX, Institute for Nuclear Medicine, Vienna and Department of Nuclear Medicine, University of Vienna, Vienna, Austria.
authors.forename: I
authors.initials: I
authors.lastname: Schweeger
authors.forename: P
authors.initials: P
authors.lastname: Fitscha
authors.forename: H
authors.initials: H
authors.lastname: Sinzinger
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001944:Breath Tests; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D017291:Clarithromycin / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood / Q000150:complications; D005260:Female; D005340:Fibrinogen / Q000187:drug effects* / Q000378:metabolism; D005500:Follow-Up Studies; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D009853:Omeprazole / Q000031:analogs & derivatives; D000077402:Pantoprazole; D013454:Sulfoxides / Q000627:therapeutic use; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D014508:Urea
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D013454:Sulfoxides; D014280:Triglycerides; D008795:Metronidazole; D014508:Urea; D005340:Fibrinogen; D000077402:Pantoprazole; D017291:Clarithromycin; D009853:Omeprazole