Selective sparing of NADPH-d positive spinal cord neurons affected by ischemia.
Histochemical characterization of NADPH diaphorase positive neuronal pools in the rabbit lumbosacral segments was performed during and after transient spinal cord ischemia. Strongly enhanced staining of NADPH diaphorase positive structures appeared in the superficial dorsal horn, the pericentral region and in the neurons of the sacral parasympathetic nucleus at the end of 40 min of abdominal aorta ligation or after 1 day reperfusion. Four days after ischemia, NADPH-d positive neurons and vessels were detected in the central gray matter despite well developed necrosis in this location. Regional nitric oxide synthesis and its vasodilatatory effect during the period of aortic occlusion may account for the observed selective resistance of these spinal cord neurons to transient ischemia.
Kluchová
D
D
Department of Anatomy, Medical Faculty of Safárik University, Kosice, Slovakia. kluch@dodo.sk
Marsala
J
J
D000818:Animals; D005260:Female; D007511:Ischemia / Q000201:enzymology* / Q000473:pathology; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009336:Necrosis; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D011817:Rabbits; D015427:Reperfusion Injury / Q000201:enzymology / Q000473:pathology; D013116:Spinal Cord / Q000098:blood supply* / Q000201:enzymology* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
D009252:NADPH Dehydrogenase