Studies of methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804) 2: effect on certain antioxidant enzyme systems in mice bearing Ehrlich ascites carcinoma.
In order to decrease toxicity and/or increase radiosensitizing activity, a new 2-nitroimidazole derivative, methyl 2-nitroimidazole-1-acetohydroxamate (KIN-804), was synthesized to solve the problem of tumor hypoxia. Evaluation of the efficiency of KIN-804 was carried out through studying the antioxidant enzyme system: The superoxide dismutase (SOD), catalase and lipid peroxide levels provide a rough index of the balance between free radical generation and scavenging. Female albino mice were inoculated with Ehrlich ascites carcinoma (EAC) in the thigh. The administration of KIN-804 (i.p. 80 mg/kg body weight) was carried out 20 min before localized irradiation of 10 Gy. In general, the data revealed that KIN-804 administration, followed or not by gamma irradiation, exerted significant inhibition of SOD and catalase activities accompanied by a significant increase in lipid peroxide level in tumor-bearing mice.
Abu-Zeid
M
M
Department of Cancer Biology, National Cancer Institute, Cairo University, Egypt.
Hori
H
H
Nagasawa
H
H
Uto
Y
Y
Inayama
S
S
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D002374:Catalase / Q000097:blood / Q000378:metabolism / Q000528:radiation effects; D005260:Female; D006877:Hydroxamic Acids / Q000494:pharmacology*; D000860:Hypoxia / Q000201:enzymology; D008054:Lipid Peroxides / Q000097:blood / Q000378:metabolism / Q000528:radiation effects; D008099:Liver / Q000201:enzymology; D008168:Lung / Q000201:enzymology; D051379:Mice; D009593:Nitroimidazoles / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism / Q000528:radiation effects
D000975:Antioxidants; D006877:Hydroxamic Acids; D008054:Lipid Peroxides; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; C076264:2-nitroimidazole-1-methylacetohydroxamate; D002374:Catalase; D013482:Superoxide Dismutase