title: Smads as transcriptional co-modulators.
abstract: The Smad signalling pathway is critical for transmitting transforming growth factor-beta (TGF-beta) superfamily signals from the cell surface to the nucleus. In the nucleus, Smads regulate transcriptional responses by recruiting co-activators and co-repressors to a wide array of DNA-binding partners. Thus, Smads function as transcriptional co-modulators to regulate TGFbeta-dependent gene expression.
authors.affiliation: Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada. liliana.attisano@utoronto.ca
authors.forename: L
authors.initials: L
authors.lastname: Attisano
authors.forename: J L
authors.initials: JL
authors.lastname: Wrana
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002467:Cell Nucleus / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004330:Drosophila; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D012697:Serine Endopeptidases; D015398:Signal Transduction; D051901:Smad4 Protein; D015534:Trans-Activators / Q000378:metabolism*; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; C497796:SMAD4 protein, human; D051901:Smad4 Protein; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D014452:Ubiquitins; C116420:ZFYVE16 protein, human; D012697:Serine Endopeptidases