Uveal effusion syndrome: clinical features, surgical treatment, histologic examination of the sclera, and pathophysiology.
OBJECTIVE
To clarify clinical features and pathophysiology and to evaluate surgical outcome of subscleral sclerectomy for primary uveal effusion syndrome.


METHODS
Prospective, consecutive noncomparative case series.


METHODS
Nineteen eyes of 16 patients diagnosed with uveal effusion syndrome treated in our clinic between 1989 and 1998.


METHODS
Patients were examined by routine ophthalmologic examinations, fluorescein and indocyanine green angiography; measurement of the axial length of the eyeball; magnetic resonance imaging; and echography. Subscleral sclerectomy (sclerectomy under the scleral flap) was performed at the equator on all patients. Histologic examination of excised sclera was carried out on all samples. Patients were followed for outcome over time.


METHODS
Reattachment of the choroid and retina with resolution of the serous fluid.


RESULTS
Three subgroups were identified: In type 1, nanophthalmic eye; the eyeball is small (average axial length 16 mm) and high hypermetropic (average +16 diopters); in type 2, the eyeball size is normal (average axial length 21 mm) with small refractive error; and in type 3, the eyeball size is normal. Histologically, types 1 and 2 demonstrated abnormal sclera with disorganization of collagen fiber bundles and deposits of proteoglycans in the matrix, whereas type 3 showed normal sclera. Subscleral sclerectomy was effective for types 1 and 2, inducing postoperative resolution of the subretinal fluid. However, type 3 eyes were not helped by this technique.


CONCLUSIONS
Primary uveal effusion syndrome is caused by abnormalities of the sclera and increased resistance to transscleral fluid outflow as subscleral sclerectomy is an effective treatment in types 1 and 2 only, correct preoperative classification is essential for early surgical management.
Uyama
M
M
Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan.
Takahashi
K
K
Kozaki
J
J
Tagami
N
N
Takada
Y
Y
Ohkuma
H
H
Matsunaga
H
H
Kimoto
T
T
Nishimura
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000648:ultrastructure; D005122:Exudates and Transudates; D005124:Eye Abnormalities / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D008279:Magnetic Resonance Imaging; D008297:Male; D008850:Microphthalmos / Q000150:complications / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D011446:Prospective Studies; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D012590:Sclera / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery / Q000648:ultrastructure*; D012599:Sclerostomy; D013577:Syndrome; D014603:Uveal Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000601:surgery
D003094:Collagen; D007208:Indocyanine Green