Structural investigations of calcium and zinc binding in proteins.
Metal ions are used in a variety of ways in our cells to regulate, activate, and stabilise specific protein molecules. In this review, we describe some of the regulatory functions of calcium and zinc that have been examined using X-ray crystallographic structural studies of specific proteins. These studies indicate that very precise control of cellular activity can be achieved by exploiting the specific physio-chemical properties of different metal ions.
Brodersen
D E
DE
Institute of Molecular and Structural Biology, Aarhus University, Denmark.
Kjeldgaard
M
M
D000595:Amino Acid Sequence; D001665:Binding Sites; D020013:Calcium Signaling; D002135:Calcium-Binding Proteins / Q000737:chemistry* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000502:physiology*; D011487:Protein Conformation; D015032:Zinc / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D015032:Zinc