title: Common complications of advanced cancer.
abstract: Complications due to cancer and its treatment are common and increase in incidence and severity as the disease progresses. Central nervous system complications affect 15% to 20% of patients, and up to 75% have bone metastases at some point during the disease process. Endocrine abnormalities include hypercalcemia, adrenal insufficiency, and inappropriate antidiuretic syndrome. Hematologic disorders, malignant effusions, and gastrointestinal (GI) problems may cause significant morbidity.
authors.affiliation: Harry R. Horvitz Center for Palliative Medicine, the Department of Hematology/Medical Oncology, and the Taussig Cancer Center, The Cleveland Clinic, OH 44195, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Nelson
authors.forename: D
authors.initials: D
authors.lastname: Walsh
authors.forename: O
authors.initials: O
authors.lastname: Abdullah
authors.forename: F
authors.initials: F
authors.lastname: McDonnell
authors.forename: J
authors.initials: J
authors.lastname: Homsi
authors.forename: S
authors.initials: S
authors.lastname: Komurcu
authors.forename: S B
authors.initials: SB
authors.lastname: LeGrand
authors.forename: D S
authors.initials: DS
authors.lastname: Zhukovsky
mesh_terms: D018450:Disease Progression; D004700:Endocrine System Diseases / Q000209:etiology / Q000628:therapy; D005767:Gastrointestinal Diseases / Q000209:etiology / Q000628:therapy; D006402:Hematologic Diseases / Q000209:etiology / Q000628:therapy; D006801:Humans; D009135:Muscular Diseases / Q000209:etiology / Q000628:therapy; D009369:Neoplasms / Q000150:complications* / Q000628:therapy*; D009422:Nervous System Diseases / Q000209:etiology / Q000628:therapy; D010166:Palliative Care; D014652:Vascular Diseases / Q000209:etiology / Q000628:therapy