Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity.
Nan
F
F
Drug Discovery Program, Georgetown Institute for Cognitive & Computational Sciences, Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, N.W., Washington, D.C. 20007-2197, USA.
Bzdega
T
T
Pshenichkin
S
S
Wroblewski
J T
JT
Wroblewska
B
B
Neale
J H
JH
Kozikowski
A P
AP
D000818:Animals; D016466:CHO Cells; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors*; D002460:Cell Line; D006224:Cricetinae; D004151:Dipeptides / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043425:Glutamate Carboxypeptidase II; D005977:Glutarates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D010721:Phosphinic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D004151:Dipeptides; D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; D005977:Glutarates; D008024:Ligands; D010721:Phosphinic Acids; D018094:Receptors, Metabotropic Glutamate; C406223:bis(glutar-2-ylmethyl)phosphinic acid; C102718:metabotropic glutamate receptor 3; C027172:isospaglumic acid; D002268:Carboxypeptidases; D043425:Glutamate Carboxypeptidase II