Isolation of iso-grayanotoxin II from leaves of Leucothoe grayana Max. Its X-ray crystallographic analysis and acute toxicity in mice.
The structure of iso-grayanotoxin II, a new diterpenoid from Leucothoe grayana MAX., has been determined as 3 beta,5 beta,6 beta,14 beta,16 alpha-pentahydroxygrayanotox-9(10)-ene by spectroscopic and X-ray crystallographic analysis. The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III.
Terai
T
T
Department of Applied Chemistry, Osaka Institute of Technology, Japan.
Araho
D
D
Osakabe
K
K
Katai
M
M
Narama
I
I
Matsuura
T
T
Katakawa
J
J
Tetsumi
T
T
Sato
M
M
D000818:Animals; D002849:Chromatography, Gas; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D007536:Isomerism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry*; D010947:Plants, Toxic / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014118:Toxins, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
D004224:Diterpenes; D014118:Toxins, Biological; C020750:grayanotoxin II