title: Connective tissue-type mast cell leukemia in a dog.
abstract: An unusual case diagnosed as connective tissue-type mast cell leukemia with marked mastocyte infiltration into visceral organs in a seven-year-old female Curly-Coated retriever is presented. Acute circulatory collapse, emesis, diarrhea, abdominal enlargement, icterus, cyanosis, dyspnea, pulmonary edema, hepatomegary, ascites, and right ventricular enlargement were observed. Hematologic and biochemical examinations revealed mast cell leukemia, mature neutrophilia, monocytosis, thrombocytopenia, hemolytic hyperbilirubinemia, hyperhistaminemia, renal and hepatic injuries. Mast cells were distributed systemically, but predominantly in the diaphragm and liver with a large mass among the serosa of ileum, cecum and colon. Mast cells were stained intensely by both safranin and berberine sulfate.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Tottori University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Hikasa
authors.forename: T
authors.initials: T
authors.lastname: Morita
authors.forename: Y
authors.initials: Y
authors.lastname: Futaoka
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.forename: K
authors.initials: K
authors.lastname: Kagota
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D001599:Berberine / Q000032:analysis; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007946:Leukemia, Mast-Cell / Q000473:pathology / Q000662:veterinary*; D010619:Phenazines / Q000032:analysis
chemical_list: D010619:Phenazines; D001599:Berberine; C009195:safranine T