title: Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase.
abstract: Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 3-days treated with L-carnitine and then with one administration of 7-MEOTA. Both compounds increased ChAT activity when administered separately. 3-day treatment of CRT followed by administration of 7-MEOTA normalized ChAT activity.
authors.affiliation: Military Medical Academy, Hradec Králové, Czech Republic. bajgar@pmfhk.cz
authors.forename: J
authors.initials: J
authors.lastname: Bajgar
authors.forename: F
authors.initials: F
authors.lastname: Skopec
authors.forename: J
authors.initials: J
authors.lastname: Herink
authors.forename: J
authors.initials: J
authors.lastname: Patocka
authors.forename: J
authors.initials: J
authors.lastname: Kvetina
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000201:enzymology*; D002331:Carnitine / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000201:enzymology*; D007700:Kinetics; D009474:Neurons / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013619:Tacrine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D013619:Tacrine; C016222:7-methoxytacrine; D002795:Choline O-Acetyltransferase; D002331:Carnitine