Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis.
Bioassay-guided fractionation of an H2O extract of the root of Scutellaria baicalensis has furnished an in vitro antigenotoxic flavonoid, baicalein (1) and 2',5,5',7-tetrahydroxy-6',8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine mutagenicity in the Salmonella typhimurium bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5 microM, reduced the frequency of chromosome aberration induced by AFB1 but increased the clastogenic effect of AFB1 at a concentration of 50 microM.
Lee
B H
BH
Lee
S J
SJ
Kang
T H
TH
Kim
D H
DH
Sohn
D H
DH
Ko
G I
GI
Kim
Y C
YC
D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors*; D016587:Antimutagenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
D016587:Antimutagenic Agents; D044950:Flavanones; D005419:Flavonoids; C006680:baicalein; D016604:Aflatoxin B1