[PPARs, cancer cells and inflammation].
The peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a ligand-dependent nuclear receptor that has been implicated in the modulation of aspects of development and homeostasis, including adipocyte differentiation and glucose metabolism. Recent reports indicate that PPAR gamma is also expressed at significant level in several other tissues, including macrophages, monocytes and aortic smooth muscle and cancer cells. In this point of view, PPARs are susceptible to mediated the modulation of immune cell activation and tumor cell differentiation. If a major role for PPARs in tumor cell differentiation is manifested, PPARs may also provide a link between nutrition and certain types of cancers.
Tomita
K
K
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University.
Hanafusa
T
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002454:Cell Differentiation; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D009369:Neoplasms / Q000473:pathology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000502:physiology*; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones; D014157:Transcription Factors / Q000819:agonists / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; C089946:2,4-thiazolidinedione