IX. Mast cell-deficient mice and intestinal biology.
Mutant mice that express abnormalities in mast cell development represent a powerful tool for the investigation of multiple aspects of mast cell biology. In addition, the identification of the genes affected by these mutations has not only increased our knowledge about the mast cell but has opened new areas of investigation as to the role of these gene products in gastrointestinal pathology, immunology, and physiology.
Wershil
B K
BK
Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA. bkwershil@aol.com
D000818:Animals; D002452:Cell Count; D002874:Chromosome Mapping; D004068:Digestive System Physiological Phenomena; D005818:Genetic Engineering; D007107:Immune System / Q000502:physiology; D007422:Intestines / Q000502:physiology*; D008407:Mast Cells / Q000166:cytology* / Q000502:physiology*; D051379:Mice; D008817:Mice, Mutant Strains / Q000033:anatomy & histology* / Q000235:genetics / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology
D009479:Neuropeptides