Synthesis of peptides mimicking chemokine receptor CCR5 and their inhibitory effects against HIV-1 infection.
Peptides mimicking chemokine receptor CCR5 were synthesized and their anti-HIV-1 activities evaluated. Prepared compounds, especially a sulfated derivatives, showed significant anti-HIV-1 activities. Furthermore, a hybrid molecule linked to an N-carbomethoxycarbonyl-prolyl-phenylalanine (CPF) moiety had a greater effect.
Konishi
K
K
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Ikeda
K
K
Achiwa
K
K
Hoshino
H
H
Tanaka
K
K
D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015699:HIV Envelope Protein gp120 / Q000187:drug effects; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*; D019713:Receptors, CCR5 / Q000737:chemistry* / Q000187:drug effects
D019380:Anti-HIV Agents; D015699:HIV Envelope Protein gp120; D010455:Peptides; D019713:Receptors, CCR5