Regulation of the cdk inhibitor p27 and its deregulation in cancer.
p27 is a cell cycle inhibitor whose cellular abundance increases in response to many antimitogenic stimuli. In this review, we summarize the current knowledge on p27 function and its regulation by synthesis and by ubiquitin-mediated degradation. Importantly, p27 degradation is enhanced in many aggressive human tumors. The frequency with which this is observed suggests that loss of p27 may confer a growth advantage to these cancers. From a practical point of view, immunodetection of p27 in tumors may prove to be useful in the assessment of prognosis and may ultimately influence the therapy of this disease.
Slingerland
J
J
Department of Medicine, University of Toronto, Toronto Ontario, Canada.
Pagano
M
M
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D018797:Cell Cycle Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors; D006706:Homeostasis; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000032:analysis / Q000502:physiology*; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology*; D025521:Tumor Suppressor Proteins
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D008869:Microtubule-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D018844:Cyclin-Dependent Kinases