L-DOPA-induced neurotoxic and apoptotic changes on cultured chromaffin cells.
Adrenal chromaffin cell (ACC) transplantation has been considered as one of the therapeutic strategies for Parkinson disease (PD). This strategy involves the administration of L-DOPA, although in reduced doses, to ACC-transplanted patients. Using cytochemical and morphological methods, we examined the effects of clinically applicable concentrations of L-DOPA on cultured chromaffin cells. We found an increase of cell death in both necrotic and apoptotic patterns. These data suggest that therapeutic preventive measures during ACC transplantation processes for PD should be taken.
Corona-Morales
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Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, DF.
Castell
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Zhang
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D000818:Animals; D017209:Apoptosis; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D019439:Chromaffin Cells / Q000187:drug effects* / Q000473:pathology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D020287:In Situ Nick-End Labeling; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D009336:Necrosis; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009498:Neurotoxins; D007980:Levodopa