[Effect of ionizing radiation on functional activity of macrophagesĭ].
It was shown that in vitro irradiation (8 Gy) of murine peritoneal macrophages suppressed their spontaneous cytotoxity and induced growth-stimulating activity. Exposure to 4 Gy induced mRNA proximal factors--TGF-beta and TNF-alpha and boosted growth-stimulating activity. These effects should be considered when evaluating efficacy of radiotherapy for tumors.
Zubova
S G
SG
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Bykova
T B
TB
Zaritskii
A Iu
AIu
Myshkov
A I
AI
Okulov
V B
VB
D000818:Animals; D017737:Macrophages, Peritoneal / Q000378:metabolism* / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D012333:RNA, Messenger / Q000528:radiation effects; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D016212:Transforming Growth Factor beta / Q000528:radiation effects; D014409:Tumor Necrosis Factor-alpha / Q000528:radiation effects
D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha