Simultaneous determination of tinidazole, furazolidone and diloxanide furoate in a combined tablet preparation by second-derivative spectrophotometry.
A second-derivative spectrophotometric procedure has been developed for the simultaneous determination of tinidazole (TD), furazolidone (FD) and diloxanide furoate (DF) in a commercial preparation. The method consists of the utilization of second-derivative absorption spectra of tablet extract in distilled water and then determination of the analyte concentration in the mixture was carried out using zero-crossing (ZC) and ratio-compensation (RC) techniques. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of TD (5-20 microg ml(-1)), FD (2.5-10 microg ml(-1)) and DF (7.5-15 microg ml(-1)). The results were found to be accurate and free from interference. The details of the statistical treatment of analytical data are also presented.
Prasad
C V
CV
Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India. cvnp@bits-pilani.ac.in
Sripriya
V
V
Saha
R N
RN
Parimoo
P
P
D000981:Antiprotozoal Agents / Q000032:analysis*; D004338:Drug Combinations; D005663:Furans / Q000032:analysis; D005664:Furazolidone / Q000032:analysis; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013607:Tablets / Q000032:analysis; D014011:Tinidazole / Q000032:analysis
D000981:Antiprotozoal Agents; D004338:Drug Combinations; D005663:Furans; D013607:Tablets; D014011:Tinidazole; D005664:Furazolidone; C004932:diloxanide furoate