Studies on muscarinic M2 receptors in smooth muscle.
Histamine after M3 receptor alkylation with 4-DAMP mustard does not serve simply as a spasmogen but facilitates visualization of the M2-mediated contraction induced by oxotremorine M. We speculate that M3 receptor activation has a similar role in untreated tissue. The facilitation appears to involve protein kinase C. The results with propranolol suggest that the phospholipase D pathway may also be important in the development of the M2-mediated response.
Mitchelson
F
F
Department of Pharmaceutical Biology and Pharmacology, Victorian College of Pharmacy, Monash University, Parkville, Australia.
Shen
A
A
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D002432:Cecum / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D018721:Muscarinic Agonists / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010095:Oxotremorine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D043585:Receptor, Muscarinic M2; D043587:Receptor, Muscarinic M3; D011976:Receptors, Muscarinic / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D018721:Muscarinic Agonists; D043585:Receptor, Muscarinic M2; D043587:Receptor, Muscarinic M3; D011976:Receptors, Muscarinic; D010095:Oxotremorine; D006632:Histamine; D011433:Propranolol; D007545:Isoproterenol