Prostate-seminal vesicle cancers induced in noble rats.
Susceptibility of Noble strain rats to induced cancers in the accessory sex glands was determined. Following an IV inoculation of methylnitrosourea plus three successive SC implants of testosterone propionate, early stage adenocarcinomas were observed in the seminal vesicles and anterior prostates, but not in the dorsolateral nor in the ventral lobes.
Pollard
M
M
Lobund Laboratory, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Wolter
W R
WR
Sun
L
L
D000818:Animals; D004195:Disease Models, Animal; D005834:Genital Neoplasms, Male / Q000139:chemically induced / Q000473:pathology*; D005856:Germ-Free Life; D008297:Male; D008770:Methylnitrosourea; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles; D013739:Testosterone
D013739:Testosterone; D008770:Methylnitrosourea