title: Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.
abstract: Oximes having 5-benzyl-2,4-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evaluated. Biaromatic and methyl groups, attached to the oxime moiety, and the ethylene bridge between oxime and phenoxy groups are favorable to biological activities.
authors.affiliation: Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. hyanag@shina.sankyo.co.jp
authors.forename: H
authors.initials: H
authors.lastname: Yanagisawa
authors.forename: M
authors.initials: M
authors.lastname: Takamura
authors.forename: E
authors.initials: E
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Fujita
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: M
authors.initials: M
authors.lastname: Yachi
authors.forename: A
authors.initials: A
authors.lastname: Isobe
authors.forename: Y
authors.initials: Y
authors.lastname: Hagisawa
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004341:Drug Evaluation; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology; D007536:Isomerism; D051379:Mice; D008815:Mice, Inbred Strains; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000378:metabolism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014157:Transcription Factors / Q000819:agonists / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010091:Oximes; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D014157:Transcription Factors