title: Tyrosine sulfation: a modulator of extracellular protein-protein interactions.
abstract: Tyrosine sulfation is a post-translational modification of many secreted and membrane-bound proteins. Its biological roles have been unclear. Recent work has implicated tyrosine sulfate as a determinant of protein-protein interactions involved in leukocyte adhesion, hemostasis and chemokine signaling.
authors.affiliation: Departments of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Kehoe
authors.forename: C R
authors.initials: CR
authors.lastname: Bertozzi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites / Q000235:genetics; D001808:Blood Vessels / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D011499:Protein Processing, Post-Translational; D019707:Receptors, Chemokine / Q000378:metabolism; D013431:Sulfates / Q000378:metabolism; D015238:Sulfotransferases / Q000737:chemistry / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D016326:Extracellular Matrix Proteins; D019707:Receptors, Chemokine; D013431:Sulfates; C005662:tyrosine O-sulfate; D014443:Tyrosine; D015238:Sulfotransferases; C039079:protein-tyrosine sulfotransferase