title: 17O-decoupled (1)H spectroscopy and imaging with a surface coil: STEAM decoupling.
abstract: (17)O-decoupled (1)H spin-echo imaging has been reported as a means of indirect (17)O detection, with potential application to measurement of blood flow and metabolism. In its current form, (17)O decoupling requires large RF amplitudes and a 180 degrees refocusing pulse, complicating its application in volume and surface coils, respectively. To overcome this problem, we have developed an (17)O-decoupled proton stimulated echo sequence ("STEAM decoupling") to allow (17)O detection with a surface coil. A high B(1) amplitude is easily generated, allowing complete decoupling of (17)O and (1)H. Slice-selective, (17)O-decoupled (1)H imaging is readily performed and the sequence is easily adapted for localized spectroscopy. Intrinsic correction for variations in B(1) and further compensation for B(1) inhomogeneity are discussed.
authors.affiliation: Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Charagundla
authors.forename: U
authors.initials: U
authors.lastname: Duvvuri
authors.forename: E A
authors.initials: EA
authors.lastname: Noyszewski
authors.forename: R
authors.initials: R
authors.lastname: Dandora
authors.forename: A H
authors.initials: AH
authors.lastname: Stolpen
authors.forename: J S
authors.initials: JS
authors.lastname: Leigh
authors.forename: R
authors.initials: R
authors.lastname: Reddy
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D010103:Oxygen Isotopes; D051381:Rats
chemical_list: D010103:Oxygen Isotopes; D006859:Hydrogen