Inhibition of cryptosporidium parvum in vitro by 9-(alkylthio)acridine derivatives.
The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.
Khalifa
L
L
Institute of Biotechnology, Faculty of Science, University of Granada, Spain.
Rosales
M J
MJ
Mascaro
C
C
Karolak-Wojciechowska
J
J
Bsiri
N
N
Brouant
P
P
Barbe
J
J
D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D002460:Cell Line; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000254:growth & development; D005243:Feces / Q000469:parasitology; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D000166:Acridines; D003049:Coccidiostats