Progress in molecular genetics of autosomal dominant polycystic kidney disease.
Among the prevalent human genetic disorders, human autosomal dominant polycystic kidney disease is certainly one of the most challenging, both from a clinical and a fundamental perspective. In the recent years, important progress opened novel research avenues to elucidate the genetic basis, the cellular pathophysiologic mechanisms and the molecular function of genes and proteins involved in autosomal dominant polycystic kidney disease.
Trudel
M
M
Institut de Recherches Cliniques de Montreal, Molecular Genetics and Development, Faculte de Medecine de l'Universite de Montreal, Montreal, Quebec H2W 1R7 Canada. Trudelm@IRCM.qc.ca
Guillaume
R
R
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D050396:TRPP Cation Channels
D008565:Membrane Proteins; D011506:Proteins; D050396:TRPP Cation Channels