Genomic-scale gene expression profiling of normal and malignant immune cells.
Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene expression physiology of immune cells appears remarkably ordered and logical. Each stage of lymphocyte differentiation can be defined by a characteristic gene expression signature. Genes that are co-regulated over hundreds of experimental conditions often encode functionally related proteins. Gene expression profiles also provide unprecedented ability to define the molecular and functional relationships between normal and malignant lymphocyte cell populations.
Alizadeh
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AA
Department of Biochemistry, M309 Genetics, Alway Building, Stanford University School of Medicine, Stanford, CA 94305, USA.
Staudt
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LM
D000465:Algorithms; D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis / Q000235:genetics; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation / Q000235:genetics; D002461:Cell Line, Transformed; D054278:Embryonal Carcinoma Stem Cells; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D016678:Genome; D018858:Germinal Center / Q000166:cytology; D006801:Humans; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000276:immunology; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D005819:Genetic Markers; D012333:RNA, Messenger; D012334:RNA, Neoplasm