Social memory is impaired in neonatally ibotenic acid lesioned rats.
Postnatal lesion with ibotenic acid in the ventral hippocampus produces several behavioural effects that resemble the symptoms of schizophrenia. In the present study, we tested neonatally lesioned 1-year-old Sprague-Dawley rats for their social memory. It was found that social memory is worsened in lesioned rats. Subchronic treatment with haloperidol (0.025 mg/kg body weight) partly ameliorated this impairment. It was suggested that social memory might be a useful paradigm to test clinically used and potential antipsychotic drugs for their effects on learning and memory processes.
Becker
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A
Faculty of Medicine, Otto-von-Guericke University, Institute of Pharmacology and Toxicology, Leipziger Str. 44, 39120, Magdeburg, Germany. axel.becker@medizin.uni-magdeburg.de
Grecksch
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G
D000818:Animals; D000831:Animals, Newborn; D001931:Brain Mapping; D004195:Disease Models, Animal; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D007051:Ibotenic Acid / Q000494:pharmacology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000503:physiopathology; D012919:Social Behavior
D018691:Excitatory Amino Acid Antagonists; D007051:Ibotenic Acid