Spontaneous oscillation of oxy- and deoxy- hemoglobin changes with a phase difference throughout the occipital cortex of newborn infants observed using non-invasive optical topography.
We investigated spontaneous changes in the cerebral oxygenation state of infants during quiet sleeping by using a form of multi-channel near-infrared spectroscopy: non-invasive optical topography. Eight infants born at 32-39 weeks were studied at postconceptional term age (38-43 weeks). Spatially synchronized oscillations of changes in the concentration of oxy- and deoxy- hemoglobin ([oxy-Hb] and [deoxy-Hb]) were observed throughout the occipital cortex. Time series analysis based on the theory of non-linear oscillators showed that the mean periods of the oscillation for each infant ranged from 11 to 18 s. The phase lag of [oxy-Hb] relative to [deoxy-Hb] was stable at about 3pi/4. This phase difference may result from interplay between the vasomotion and the oxygen consumption in relation to brain activity.
Taga
G
G
Department of Pure and Applied Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo, Japan. taga@complex.c.u-tokyo.ac.jp
Konishi
Y
Y
Maki
A
A
Tachibana
T
T
Fujiwara
M
M
Koizumi
H
H
D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D009778:Occipital Lobe / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism*; D012890:Sleep / Q000502:physiology; D019265:Spectroscopy, Near-Infrared
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin