title: High prevalence of antithyroid antibodies in anti-glomerular basement membrane antibody-mediated disease.
abstract: Anti-glomerular basement membrane antibody (anti-GBM Ab)-mediated disease and autoimmune thyroiditis are characterized by the presence of organ-specific antibodies. The diagnosis of autoimmune thyroiditis is usually based on the presence of serum antithyroid antibodies. Few studies have addressed the relationship between anti GBM-Ab mediated disease and autoimmune thyroid pathology. Given that this disorder is often asymptomatic, associations of the two pathologies may be under-diagnosed. This study investigated the prevalence of serum antithyroid antibodies (antithyroglobulin (anti-TG) and anti-thyroid peroxidase (anti-TPO)) in patients with anti-GBM Ab-mediated disease. Antithyroid antibodies presence was investigated in sera from 35 patients in whom anti-GBM Ab-mediated disease had been diagnosed. Anti-glomerular basement membrane antibodies and anti-thyroid antibodies (anti-TG and anti-TPO) were assayed using an enzyme-linked immunosorbent assay. Forty-five percent of patients with anti-GBM Ab-mediated disease (16/35) had positive antithyroid antibody titers. Eighteen percent (3/16) suffered from subclinical hypothyroidism. In conclusion, the high prevalence of antithyroid antibodies in these patients suggests a possible pathogenic link between autoimmune thyroiditis and anti GBM Ab-mediated disease.
authors.affiliation: Nephrology Service, Hospital Clinic, University of Barcelona, Catalonia, Spain. emirapei@medicina.ub.es
authors.forename: J
authors.initials: J
authors.lastname: Ara
authors.forename: J
authors.initials: J
authors.lastname: Robert
authors.forename: E
authors.initials: E
authors.lastname: Mirapeix
authors.forename: A
authors.initials: A
authors.lastname: Botey
authors.forename: A
authors.initials: A
authors.lastname: Darnell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019867:Anti-Glomerular Basement Membrane Disease / Q000097:blood* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013961:Thyroid Gland / Q000276:immunology*
chemical_list: D001323:Autoantibodies