Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in immunocompromised patients.
Recent studies have shown that mutations in two amino acid positions of the Pneumocystis carinii dihydropteroate synthase gene are significantly more common in immunocompromised patients with P. carinii pneumonia who fail sulfa or sulfone prophylaxis. This paper reviews the studies that suggest that these mutations may be responsible for some failures of prophylaxis in P. carinii.
Armstrong
W
W
Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA.
Meshnick
S
S
Kazanjian
P
P
D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004094:Dihydropteroate Synthase / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans; D016867:Immunocompromised Host; D009154:Mutation; D010419:Pentamidine / Q000627:therapeutic use; D011010:Pneumocystis / Q000201:enzymology / Q000235:genetics*; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D013449:Sulfonamides / Q000627:therapeutic use; D013450:Sulfones / Q000627:therapeutic use
D000890:Anti-Infective Agents; D013449:Sulfonamides; D013450:Sulfones; D010419:Pentamidine; D004094:Dihydropteroate Synthase