Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. I. Taxonomy, production, isolation and biological activities.
Two new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule, adxanthromycins A and B were isolated from the cultured broth of a streptomycete strain. The strain was identified as Streptomyces sp. NA-148 from its morphological and physiological characteristics. Adxanthromycins A and B inhibited the formation of the JY cell aggregates from 1.5 microg/ml, respectively, in a dose dependent manner. Components A and B also inhibited a human T cell leukemia cell line SKW-3 adhesion to soluble ICAM-1 in a dose-dependent manner with an IC50 of 18.8 microg/ml and 25.0 microg/ml, respectively.
Nakano
T
T
Department of Biosciences, Teikyo University, Utsunomiya, Japan.
Koiwa
T
T
Takahashi
S
S
Nakagawa
A
A
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000187:drug effects*; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010545:Peroxides / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014966:Xanthenes / Q000302:isolation & purification / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D016169:Lymphocyte Function-Associated Antigen-1; D010545:Peroxides; D014966:Xanthenes; C406042:adxanthromycin A; C406043:adxanthromycin B; D018799:Intercellular Adhesion Molecule-1