The effect of hyaluronic acid-carboxymethylcellulose in reducing adhesion reformation in rabbits.
The effect of hyaluronic acid-carboxymethylcellulose film (Seprafilm) in reducing postoperative adhesion formation was examined in a rabbit induced-adhesion model. During laparotomy, the ileocaecal region was mechanically and chemically abraded to induce lesions. After a 28-day recovery period, adhesions were lysed by microsurgery and Seprafilm was applied to the lysed lesion in 10 rabbits and six rabbits received physiological saline. A third laparotomy was performed 10-14 days later and the area of adhesion reformation was compared to that found prior to application of test materials. The area of adhesion reformation with Seprafilm decreased to (mean +/- standard deviation) 11.71 +/- 10.97% of the originally lysed lesion and, the area was significantly reduced compared with controls treated with physiological saline. These results suggest that the use of Seprafilm may be a valuable new anti-adhesion material for abdominal or pelvic surgery and may be superior to existing anti-adhesion materials and techniques.
Osada
H
H
Department of Obstetrics and Gynaecology, Nihon University School of Medicine, Tokyo, Japan.
Minai
M
M
Tsunoda
I
I
Fujii
T K
TK
Tsubata
K
K
Satoh
K
K
D000818:Animals; D001672:Biocompatible Materials; D005260:Female; D006820:Hyaluronic Acid; D007813:Laparotomy; D008567:Membranes, Artificial; D008866:Microsurgery; D011183:Postoperative Complications; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control*
D001672:Biocompatible Materials; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid