[Thrombotic thrombocytopenic purpura (Moschkowitz-syndrome) caused by ticlopidine].
BACKGROUND
Only in a few case reports the thrombotic thrombocytopenic purpura was related to ticlopidine with a controversial discussion about this association.


METHODS
In a 57-year-old female patient, who was admitted with fluctuating central neurological abnormalities and generalized purpura, was made the diagnosis of a thrombotic thrombocytopenic purpura (TTP, Moschcowitz' syndrome). On admission there were a distinct anemia and thrombocytopenia. Corresponding to the hemolysis the laboratory findings showed raised reticulocytes and elevated LDH with > 900 U/l. The peripheral blood smear showed an enrichment of fragmented red cells (15%) and the bone marrow indicated a hyperplastic erythrocytopoesis and a left shift in megakaryocytopoesis. An increase of eosinophilic granulocytes and the tissue basophilic cells directed to a possible allergic phenomenon of the underlying disease. Until 3 weeks before admission she had been on ticlopidine after a left heart catheter with stenting the left coronary artery 6 weeks earlier. Beside taking of acetylsalicylacid and thyroid hormone there was no other regular medication. An early treatment with fresh frozen plasma and plasmapheresis with plasma exchange with fresh frozen plasma led directly to an elevation of thrombocytes and a normalization of hemolytic parameters.


CONCLUSIONS
This case demonstrates the possible relationship between thrombotic thrombocytopenic purpura and the administration of ticlopidine.
Chemnitz
J M
JM
Klinik I für Innere Medizin, Universität zu Köln.
Schulz
A
A
Salameh
A
A
Scheid
C
C
Müller
R
R
Draube
A
A
Diehl
V
V
Söhngen
D
D
D005260:Female; D006801:Humans; D008875:Middle Aged; D010949:Plasma; D010956:Plasmapheresis; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects; D013988:Ticlopidine / Q000009:adverse effects*; D016896:Treatment Outcome
D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine