[Clinico-diagnostic significance of fibronectin level determination in severely burnt].
Fibronectin content was determined in plasma and granulation tissues of burnt wounds in burnt patients as well as in plasma and wound exudate of patients operated on for large postoperative abdominal hernia and in whom for several days after surgery the continuous discharge of the wound exudate through the drainage tubes was observed. The same data were observed in fibroblast cultures and nutritional medium in which they have been cultured. It was established that dynamic determination of plasma fibronectin in burn disease allows to estimate the adequacy of the treatment to timely predict probability of development of complications and the outcome of the disease, while determination of fibronectin content in the granulation tissues of burn wounds indicates optimal terms for transplantation of fibroblasts and autotransplants as well as a significant increase of the effectiveness of surgical treatment for victims with spacious burns.
Alekseev
A A
AA
Lavrov
V A
VA
Ushakova
T A
TA
D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002478:Cells, Cultured; D005122:Exudates and Transudates / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D011379:Prognosis; D016038:Skin Transplantation / Q000502:physiology; D015599:Trauma Severity Indices; D014945:Wound Healing
D015415:Biomarkers; D005353:Fibronectins