Effects of insulin therapy and glycemic control on distribution of HDL alpha and pre-beta subfractions in non insulin-dependent diabetic subjects.
OBJECTIVE
The heterogeneous population of HDL particles can be separated into six classes which may provide a more sensitive index of cardiovascular risk than HDL cholesterol. The aim of this study was therefore to evaluate HDL distribution in NIDDM.


RESULTS
Twenty-five individuals were treated with diet and sulfonylurea and 14 with insulin; both groups had similar plasma lipid profiles and BMI, but the insulin-treated subjects were older and their diabetes was of longer duration. The major findings were a greater proportion of apoA1 in alpha 1-HDL in the insulin-treated group (24.3 +/- 5.2% vs 20.8 +/- 4.0%), which is a desirable profile, and a greater proportion of pre-beta 1-HDL, which are the initial acceptors of cellular cholesterol.


CONCLUSIONS
Our results suggest a beneficial influence of insulin treatment on reverse cholesterol transport. Moreover, glycemic control (HbA1c) also related to alpha 3-HDL significantly (r = 0.51; p < 0.01), indicating an association between poorer glycemic control and an adverse HDL profile.
Sasahara
T
T
Baker Medical Research Institute, University of Melbourne, Austin, Australia.
Jerums
G
G
Nestel
P
P
D000284:Administration, Oral; D000368:Aged; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000187:drug effects* / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000188:drug therapy*; D004035:Diet Therapy / Q000379:methods; D004586:Electrophoresis; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D015151:Immunoblotting; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity
D001786:Blood Glucose; D008076:Cholesterol, HDL; D007004:Hypoglycemic Agents; D007328:Insulin