SPAC: identification of polypeptides using their amino-acid composition.
We describe here new software able to retrieve from protein or nucleic acid databases, the sequence corresponding to a protein or peptide whose only amino acid composition and molecular weight are known. This algorithm is particularly devoted to the retrieval of partial sequences, a task that other available software performs poorly. Its accuracy for the attribution of a protein fragment to a sequence could represent an easy and economical first tool upstream the use of more sophisticated and expensive methods in proteomic research. SPAC (Sequence Protein Alignment with Composition) is a shareware available software on web site http://www.univ-tln.fr/ approximately grillas/SPAC/. This web site also presents help and a detailed description of the algorithm and interface.
Grillasca
J P
JP
Département de Génie Biologique, Université de Toulon et du Var, La Garde, France. grillasca@univ-tln.fr
Planells
R
R
Aubert
D
D
Antonini
F
F
D000465:Algorithms; D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D016208:Databases, Factual; D006801:Humans; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D015203:Reproducibility of Results; D016415:Sequence Alignment / Q000379:methods / Q000706:statistics & numerical data; D012984:Software
D000596:Amino Acids; D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins