title: Didanosine once daily: an overview.
abstract: The current focus on simplifying treatment regimens for patients with human immunodeficiency virus (HIV) infection has contributed to the interest in once-daily therapy. The triphosphate of didanosine (2',3'-dideoxyinosine or DDI) has a long intracellular half-life, which supports the use of didanosine in a once-daily dosing schedule. Early clinical studies found that changes in surrogate markers were similar whether didanosine was dosed once or twice daily, while toxic effects occurred less frequently with once-daily dosing. Didanosine once-a-day used in combination with other drugs has also been studied, and results of some of these trials are summarized in this paper.
authors.affiliation: Royal Free Centre for HIV Medicine, Royal Free Hospital, Hampstead, London, UK. myoule@rfh1.demon.co.uk
authors.forename: M
authors.initials: M
authors.lastname: Youle
mesh_terms: D002986:Clinical Trials as Topic; D016049:Didanosine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans
chemical_list: D016049:Didanosine