Cellular and humoral factors in colostrum of HIV infected and uninfected lactating mothers.
OBJECTIVE
To compare the cellular and humoral factors in colostrum from HIV infected and uninfected lactating mothers.


METHODS
Cross sectional study.


METHODS
Maternity Ward.


METHODS
Colostrum was collected from 130 mothers (62 HIV seropositives and 68 HIV seronegatives). These colostrum samples were tested for total cell count, cell viability, differential count, phagocytic activity of macrophages, 'T' cell counts, IgA, IgM and IgG levels.


RESULTS
There was a statistically significant decrease in the phagocytosis and 'T' cell number (p <0.001) and in the IgA and IgG levels (p<0. 05) in the colostrum obtained from HIV seropositive mothers as compared to HIV seronegative ones.


CONCLUSIONS
Some of the cellular and humoral factors are reduced in colostrum samples obtained from HIV seropositives as compared to normals.
Manohar
A A
AA
Department of Microbiology, T.N. Medical College and B.Y.L. Nair Charitable Hospital, Mumbai Central, Mumbai 400 008, India.
Williamson
M
M
Kamat
H A
HA
Koppikar
G V
GV
Merchant
R H
RH
D000293:Adolescent; D000328:Adult; D001942:Breast Feeding; D016022:Case-Control Studies; D003126:Colostrum / Q000737:chemistry* / Q000166:cytology* / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D015483:HIV Antibodies / Q000032:analysis*; D015658:HIV Infections / Q000276:immunology*; D018023:HIV Seronegativity / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D018655:Lymphocyte Count; D008264:Macrophages / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D011644:Puerperal Disorders / Q000276:immunology*; D013601:T-Lymphocytes
D015483:HIV Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M