Is mantle cell lymphoma a sex-related disease?
Mantle cell lymphomas are characterized by a male predominance with a range between 55 and 65 years (sex ratio M/F of 6.5). When the sex ratio of patients having mantle cell lymphoma was compared to that of each of the subtypes of non-Hodgkin's lymphomas, it was significantly higher in all cases except Burkitt's and lymphoblastic T-cell lymphomas. These observations suggest a possible relation between the chromosome X and mantle cell lymphomas which has to be explored.
Decaudin
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D
Department of Hematology, Institut Curie, Paris, France. didier.decaudin@curie.net
Salanoubat
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C
Carde
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P
D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D012744:Sex Ratio; D014960:X Chromosome