Novel C-ring analogues of 20(S)-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues.
Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.
Subrahmanyam
D
D
Natural Products Division, Dr. Reddy's Research Foundation, Hyderabad, AP, India. duvvuri62@hotmail.com
Sarma
V M
VM
Venkateswarlu
A
A
Sastry
T V
TV
Srinivas
A S
AS
Krishna
C V
CV
Deevi
D S
DS
Kumar
S A
SA
Babu
M J
MJ
Damodaran
N K
NK
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D002166:Camptothecin