A common polymorphism in the human insulin-like growth factor binding protein 3 gene.
A common polymorphism generated by an A to C transition at nucleotide 7580 in the third intron of the insulin-like growth factor binding protein 3 gene was found. This polymorphism can be identified by Nde 1 restriction of genomic DNA amplified with a specifically designed restriction enzyme site-generating oligonucleotide primer. The frequency of the A and C alleles was estimated at 0.6 and 0.4 in the Caucasians, 0.63 and 0.37 in Blacks, respectively.
Sun
G
G
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
Chagnon
M
M
Bouchard
C
C
D019943:Amino Acid Substitution; D044383:Black People / Q000235:genetics; D002897:Chromosomes, Human, Pair 7; D005787:Gene Frequency; D016678:Genome; D006579:Heterozygote; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D007438:Introns; D008969:Molecular Sequence Data; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D044465:White People / Q000235:genetics
D018972:Insulin-Like Growth Factor Binding Protein 3