Serotonergic modulation of the P13 midlatency auditory evoked potential in the rat.
The vertex-recorded, sleep state-dependent P13 midlatency auditory evoked potential in the rat may be generated, in part, by pedunculopontine nucleus (PPN) projections. Injections into the PPN of the 5-HT(1A) serotonin receptor agonist, 8-hydroxy-2-di-n-propylaminotetralin hydrobromide (DPAT), were found to reduce the amplitude of the P13 potential in a dose- and time-dependent manner. The suppressive effect of DPAT was blocked or reduced by pretreatment with the 5-HT(1A) serotonin receptor antagonist, Pindobind. These results show that the P13 potential can be modulated by known inhibitory serotonergic inputs to the PPN.
Miyazato
H
H
Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Skinner
R D
RD
Crews
T
T
Williams
K
K
Garcia-Rill
E
E
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D000081005:Cyclohexane Monoterpenes; D016057:Evoked Potentials, Auditory, Brain Stem; D008297:Male; D008636:Mesencephalon / Q000502:physiology*; D008845:Microinjections; D010869:Pindolol / Q000031:analogs & derivatives / Q000494:pharmacology; D011149:Pons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D000081005:Cyclohexane Monoterpenes; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C084712:pindobind; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D010869:Pindolol