title: Outcomes of cardiac surgery in patients > or = 80 years: results from the National Cardiovascular Network.
abstract: OBJECTIVE
  The purpose of this study was to evaluate characteristics and outcomes of patients age > or =80 undergoing cardiac surgery.
  
  
  BACKGROUND
  Prior single-institution series have found high mortality rates in octogenarians after cardiac surgery. However, the major preoperative risk factors in this age group have not been identified. In addition, the additive risks in the elderly of valve replacement surgery at the time of bypass are unknown.
  
  
  METHODS
  We report in-hospital morbidity and mortality in 67,764 patients (4,743 octogenarians) undergoing cardiac surgery at 22 centers in the National Cardiovascular Network. We examine the predictors of in-hospital mortality in octogenarians compared with those predictors in younger patients.
  
  
  RESULTS
  Octogenarians undergoing cardiac surgery had fewer comorbid illnesses but higher disease severity and surgical urgency than younger patients. Octogenarians had significantly higher in-hospital mortality after cardiac surgery than younger patients: coronary artery bypass grafting (CABG) only (8.1% vs. 3.0%), CABG/aortic valve (10.1% vs. 7.9%), CABG/mitral valve (19.6% vs. 12.2%). In addition, they had twice the incidence of postoperative stroke and renal failure. The preoperative clinical factors predicting CABG mortality in the very elderly were quite similar to those for younger patients with age, emergency surgery and prior CABG being the powerful predictors of outcome in both age categories. Of note, elderly patients without significant comorbidity had in-hospital mortality rates of 4.2% after CABG, 7% after CABG with aortic valve replacement (CABG/AVR), and 18.2% after CABG with mitral valve replacement (CABG/MVR).
  
  
  CONCLUSIONS
  Risks for octogenarians undergoing cardiac surgery are less than previously reported, especially for CABG only or CABG/AVR. In selected octogenarians without significant comorbidity, mortality approaches that seen in younger patients.
authors.affiliation: Outcomes Research and Assessment Group, Duke Clinical Research Institute, Durham, North Carolina 27710, USA. alexa019@mc.duke.edu
authors.forename: K P
authors.initials: KP
authors.lastname: Alexander
authors.forename: K J
authors.initials: KJ
authors.lastname: Anstrom
authors.forename: L H
authors.initials: LH
authors.lastname: Muhlbaier
authors.forename: R D
authors.initials: RD
authors.lastname: Grosswald
authors.forename: P K
authors.initials: PK
authors.lastname: Smith
authors.forename: R H
authors.initials: RH
authors.lastname: Jones
authors.forename: E D
authors.initials: ED
authors.lastname: Peterson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000401:mortality*; D003327:Coronary Disease / Q000401:mortality / Q000601:surgery*; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D051437:Renal Insufficiency / Q000453:epidemiology; D012189:Retrospective Studies; D020521:Stroke / Q000453:epidemiology; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology