title: Enhanced accumulation of pericardial fluid ferritin in patients with coronary artery disease.
abstract: BACKGROUND
  Ferritin is a storage protein for iron that can either represent a source of iron or perform a cytoprotective action as an iron sequestrant.
  
  
  OBJECTIVE
  To compare the concentrations of ferritin in pericardial fluid of patients with valvular heart disease, serving as controls, and in patients with coronary artery disease.
  
  
  METHODS
  We studied a total of 59 consecutive male patients undergoing elective heart valve replacement (group 1: n = 22, mean +/- SD age 55 +/- 11 years) or elective coronary artery bypass grafting (group 2: n = 37, mean +/- SD age 59 +/- 9 years).
  
  
  METHODS
  Iron status indicators, total protein and albumin concentrations, and lactate dehydrogenase activities were determined in pericardial fluid and serum samples obtained from patients during surgery.
  
  
  RESULTS
  Pericardial fluid concentrations of ferritin in both patient populations were significantly (P < 0.001) greater than the concentrations in sera: group 1, 375 (107-2030) micrograms/l compared with 146.5 (21-407) micrograms/l; group 2, 1115 (226-2500) micrograms/l compared with 152.0 (16-398) micrograms/l (median (range)), respectively. Moreover, pericardial fluid ferritin concentration was significantly (P < 0.01) greater in patients undergoing coronary artery bypass grafting than in those undergoing heart valve replacement, whereas serum ferritin concentrations did not differ between the two patient populations.
  
  
  CONCLUSIONS
  As pericardial fluid reflects the composition of the myocardial interstitium, we suggest that ferritin released can serve as a potential source of iron in the cardiac interstitium that may promote the generation of oxygen free radicals. Conversely, we presume that induction of ferritin synthesis, representing an important mechanism by which tissue adapts to hypoxic damage, can afford myocardial cytoprotection.
authors.affiliation: Department of Cardiovascular Surgery, Semmelweis University of Medicine, Budapest, Hungary. laszlo.selmeci@mailexcite.com
authors.forename: L
authors.initials: L
authors.lastname: Selmeci
authors.forename: M
authors.initials: M
authors.lastname: Antal
authors.forename: F
authors.initials: F
authors.lastname: Horkay
authors.forename: B
authors.initials: B
authors.lastname: Merkely
authors.forename: I
authors.initials: I
authors.lastname: Szokodi
authors.forename: L
authors.initials: L
authors.lastname: Bíró
authors.forename: M
authors.initials: M
authors.lastname: Székely
authors.forename: J
authors.initials: J
authors.lastname: Jobbágy
authors.forename: J
authors.initials: J
authors.lastname: Szépvölgyi
authors.forename: M
authors.initials: M
authors.lastname: Tóth
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology*; D005293:Ferritins / Q000032:analysis* / Q000097:blood; D006349:Heart Valve Diseases / Q000503:physiopathology; D006801:Humans; D007501:Iron / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000737:chemistry*; D012307:Risk Factors
chemical_list: D005293:Ferritins; D007501:Iron; D007770:L-Lactate Dehydrogenase