Ocular, cerebral and systemic interrelationships of cytomegalovirus infection in a post-mortem study of AIDS patients.
OBJECTIVE
Eighty-six post-mortems of AIDS patients were reviewed microscopically and the presence of cytomegalovirus (CMV) infection in the viscera, brain and eye was recorded.


METHODS
Immunohistochemical stains and in situ hybridisation with a CMV probe were performed.


CONCLUSIONS
CMV infection was observed in 63% of the cases. Visceral, cerebral and ocular involvement were overall 49%, 33% and 29%, respectively. The visceral form with no concomitant ocular and/or cerebral infection was the main cause of death (31%) in the 54 CMV-infected patients. Although CMV retinitis occurred mostly (20%) as a component of systemic disease, in 13% of the CMV-infected patients the eyes only were involved, while there were no cases with CMV limited to the brain. In the absence of systemic involvement, 9% of the cases showed concomitant ocular and cerebral infection, but because we failed to observe CMV optic neuritis without ocular involvement, retrograde viral spread from the brain through the optic nerve appears to be an infrequent mechanism of CMV retinitis.
Pecorella
I
I
Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Italy.
Ciardi
A
A
Credendino
A
A
Marasco
A
A
Di Tondo
U
U
Scaravilli
F
F
D017088:AIDS-Related Opportunistic Infections / Q000473:pathology* / Q000821:virology; D000328:Adult; D001344:Autopsy; D001927:Brain Diseases / Q000473:pathology / Q000821:virology; D015331:Cohort Studies; D003586:Cytomegalovirus Infections / Q000473:pathology; D017726:Cytomegalovirus Retinitis / Q000473:pathology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies