Activation of adenosine A1 receptors facilitates the analgesic effect of ketorolac and ketorolac-caffeine combinations in the rat.
Pérez-Urizar
J
J
Departamento de Farmacología y Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, México, D.F., Mexico.
Aguirre-Bañuelos
P
P
López-Muñoz
F J
FJ
Castañeda-Hernández
G
G
Granados-Soto
V
V
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D019540:Area Under Curve; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D020910:Ketorolac / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D010627:Phenethylamines / Q000494:pharmacology; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017208:Rats, Wistar
D018712:Analgesics, Non-Narcotic; D000697:Central Nervous System Stimulants; D010627:Phenethylamines; D058906:Purinergic P1 Receptor Agonists; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; C027513:N(6)-cyclohexyladenosine; D002110:Caffeine; D000241:Adenosine; D020910:Ketorolac