Adult mesoblastic nephroma.
We report a case of asymptomatic mesoblastic nephroma in a 54-year-old woman. The tumor showed immunohistochemical reactions similar to developing nephrons. Electron microscopy showed immature tubules with numerous intracytoplasmic intermediate filaments. Recent studies support the concept of pathogenesis of the mesoblastic nephroma originating from collecting ducts. However, this case exhibited a complex pattern of antigenic expression not restricted to the collecting ducts, but including the glycoprotein CD24 and the neural cell adhesion molecule (NCAM). The following differential diagnoses will be discussed: benign mixed epithelial and stromal tumor, metanephric adenoma, and nephrogenic adenofibroma.
Daniel
L
L
Service d'Anatomie Pathologique et de Neuropathologie, Marseille, France. ldaniel@ap-hm.fr
Lechevallier
E
E
Bouvier
C
C
Coulange
C
C
Pellissier
J F
JF
D000232:Adenofibroma / Q000175:diagnosis; D000236:Adenoma / Q000175:diagnosis; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D051927:CD24 Antigen; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007382:Intermediate Filaments / Q000648:ultrastructure; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D008562:Membrane Glycoproteins; D008875:Middle Aged; D018193:Neoplasms, Complex and Mixed / Q000175:diagnosis; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis; D018201:Nephroma, Mesoblastic / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D019006:Neural Cell Adhesion Molecules / Q000032:analysis; D014057:Tomography, X-Ray Computed
D015703:Antigens, CD; D014408:Biomarkers, Tumor; D051927:CD24 Antigen; C497889:CD24 protein, human; C507497:KRT7 protein, human; D053552:Keratin-7; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules; D007633:Keratins