title: Medical management of eosinophilic granuloma of the cervical spine.
abstract: We report a case of eosinophilic granuloma involving the vertebral bodies of the cervical spine in a 33-month-old girl. This lesion was diagnosed by needle biopsy and treated with prednisone and vinblastine therapy along with immobilization in a Minerva brace. The child has done well over a 9-month follow-up and has shown MRI evidence of resolution of the lesion, reestablishment of structural integrity within the cervical spine and potential reconstitution of the involved vertebral bodies.
authors.affiliation: Department of Neurosurgery, University of Pittsburgh Medical Center, Children's Hospital of Pittsburgh, PA 15213, USA. eilevy@juno.com
authors.forename: E I
authors.initials: EI
authors.lastname: Levy
authors.forename: A
authors.initials: A
authors.lastname: Scarrow
authors.forename: R C
authors.initials: RC
authors.lastname: Hamilton
authors.forename: M R
authors.initials: MR
authors.lastname: Wollman
authors.forename: C
authors.initials: C
authors.lastname: Fitz
authors.forename: I F
authors.initials: IF
authors.lastname: Pollack
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001707:Biopsy, Needle; D001915:Braces; D002574:Cervical Vertebrae / Q000473:pathology; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004803:Eosinophilic Granuloma / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D011241:Prednisone / Q000008:administration & dosage*; D013122:Spinal Diseases / Q000188:drug therapy* / Q000473:pathology; D014747:Vinblastine / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D011241:Prednisone