title: Sedation for vitreoretinal surgery: a comparison of anaesthetist-administered midazolam and patient-controlled sedation with propofol.
abstract: Local anaesthesia is increasingly being used for vitreoretinal surgery, but the optimal technique for sedation remains unclear. Anaesthetist-administered midazolam, which is often used, was compared in this study to patient-controlled sedation with propofol in 43 patients undergoing 50 vitreoretinal procedures. A variety of patient, anaesthetist and surgical endpoints were measured. There were no significant outcome differences between the two agents except that midazolam produced more amnesia for the local anaesthetic eye block. However, several outcomes and the observations in patients who experienced both agents showed a trend in favour of propofol for intraoperative sedation. We conclude that both approaches are safe and that patient-controlled sedation with propofol is at least as satisfactory as anaesthetist-administered midazolam.
authors.affiliation: Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, South Australia.
authors.forename: H R
authors.initials: HR
authors.lastname: Morley
authors.forename: A
authors.initials: A
authors.lastname: Karagiannis
authors.forename: D J
authors.initials: DJ
authors.lastname: Schultz
authors.forename: J C
authors.initials: JC
authors.lastname: Walker
authors.forename: H S
authors.initials: HS
authors.lastname: Newland
mesh_terms: D016292:Procedural Sedation; D018592:Cross-Over Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008874:Midazolam / Q000008:administration & dosage; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D017060:Patient Satisfaction; D015742:Propofol / Q000008:administration & dosage; D012160:Retina / Q000601:surgery*; D016896:Treatment Outcome; D014822:Vitreous Body / Q000601:surgery*
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol