title: Accuracy of echocardiographic right ventricular parameters in patients with different end-stage lung diseases prior to lung transplantation.
abstract: BACKGROUND
  Because there are few data available on the accuracy of 2D-echocardiography to assess right ventricular (RV) size and function in patients with far-advanced lung disease, in this prospective study, we compared various echocardiographic RV parameters with RV volumes derived from magnetic resonance imaging (MRI).
  
  
  METHODS
  In 32 patients (18 male, 17 female) presenting for lung transplantation, we measured RV end-diastolic and end-systolic area as well as derived RV fractional area change, long-axis diameter, short-axis diameter, tricuspid valve anulus diameter (using 2D apical or sub-costal 4-chamber view), and RV end-diastolic diameter (using M-mode in the parasternal short-axis view). These values were compared with RV end-diastolic and end-systolic volumes derived by MRI, serving as the gold standard.
  
  
  RESULTS
  Right ventricular end-diastolic area was the most accurate echocardiographic parameter of RV size (correlation to MRI: r = 0.88, p < 0.001), followed by RV end-diastolic short-axis diameter (r = 0.75, p < 0.001), long axis diameter (r = 0.66, p < 0.001), and tricuspid valve anulus diameter (r = 0.63, p < 0.001). In contrast, M-mode measurement of RV end-diastolic diameter was possible in only 24/35 (68%) patients and showed a weak correlation to MRI-derived RV end-diastolic volume (r = 0.56, p = 0.004). Right ventricular fractional area change correlated well with MRI-derived RV ejection fraction (r = 0.84, p < 0.0001). In a sub-group analysis, patients with vascular lung disease showed best agreement between both methods for RV end-diastolic area and RV fractional area change compared with patients with restrictive or obstructive lung disease.
  
  
  CONCLUSIONS
  This study shows that in patients with far-advanced lung diseases, RV end-diastolic area demonstrated the best correlation with MRI-derived measurement of RV end-diastolic volume, and RV fractional area change compared favorably with MRI-derived ejection fraction. Despite reduced image quality, especially in patients with obstructive lung disease, these parameters can yield clinically valuable information.
authors.affiliation: Department of Internal Medicine 4, University of Vienna, Austria. Peter.Schenk@akh-wien.ac.at
authors.forename: P
authors.initials: P
authors.lastname: Schenk
authors.forename: S
authors.initials: S
authors.lastname: Globits
authors.forename: J
authors.initials: J
authors.lastname: Koller
authors.forename: C
authors.initials: C
authors.lastname: Brunner
authors.forename: O
authors.initials: O
authors.lastname: Artemiou
authors.forename: W
authors.initials: W
authors.lastname: Klepetko
authors.forename: O C
authors.initials: OC
authors.lastname: Burghuber
mesh_terms: D000328:Adult; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging*; D006439:Hemodynamics; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012129:Respiratory Function Tests; D013318:Stroke Volume; D014463:Ultrasonography; D016278:Ventricular Function, Right