title: Abnormal angular gyrus asymmetry in schizophrenia.
abstract: OBJECTIVE
  Few studies have evaluated the parietal lobe in schizophrenia despite the fact that it has an important role in attention, memory, and language-all functions that have been reported to be abnormal in schizophrenia. The inferior parietal lobule, in particular, is of interest because it is not only part of the heteromodal association cortex but also is part of the semantic-lexical network, which also includes the planum temporale. Both the inferior parietal lobule, particularly the angular gyrus of the inferior parietal lobule, and the planum temporale are brain regions that play a critical role as biological substrates of language and thought. The authors compared volume and asymmetry measures of the individual gyri of the parietal lobe by means of magnetic resonance imaging (MRI) scans.
  
  
  METHODS
  MRI scans with a 1. 5-Tesla magnet were obtained from 15 male chronic schizophrenic and 15 comparison subjects matched for age, gender, and parental socioeconomic status.
  
  
  RESULTS
  Inferior parietal lobule volumes showed a leftward asymmetry (left 7.0% larger than right) in comparison subjects and a reversed asymmetry (left 6.3% smaller than right) in schizophrenic subjects. The angular gyrus accounted for this difference in asymmetry, with the left angular gyrus being significantly larger (18.7%) than the right in comparison subjects, a finding that was not observed in schizophrenic patients. A further test of angular gyrus asymmetry showed a reversal of the normal left-greater-than-right asymmetry in the schizophrenic patients.
  
  
  CONCLUSIONS
  Patients with schizophrenia showed a reversed asymmetry in the inferior parietal lobule that was localized to the angular gyrus, a structure belonging to the heteromodal association cortex as well as being part of the semantic-lexical network. This finding contributes to a more comprehensive understanding of the neural substrates of language and thought disorder in schizophrenia.
authors.affiliation: Laboratory of Neuroscience, Department of Psychiatry, VA Medical Center, Harvard Medical School, Brockton, MA 02301, USA.
authors.forename: M
authors.initials: M
authors.lastname: Niznikiewicz
authors.forename: R
authors.initials: R
authors.lastname: Donnino
authors.forename: R W
authors.initials: RW
authors.lastname: McCarley
authors.forename: P G
authors.initials: PG
authors.lastname: Nestor
authors.forename: D V
authors.initials: DV
authors.lastname: Iosifescu
authors.forename: B
authors.initials: B
authors.lastname: O'Donnell
authors.forename: J
authors.initials: J
authors.lastname: Levitt
authors.forename: M E
authors.initials: ME
authors.lastname: Shenton
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000503:physiopathology; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000503:physiopathology; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007806:Language Disorders / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010296:Parietal Lobe / Q000033:anatomy & histology* / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000503:physiopathology; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012737:Sex Factors; D013702:Temporal Lobe / Q000033:anatomy & histology / Q000503:physiopathology