title: Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.
abstract: Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid peroxidation products, decrease in cytochrome P-450 and NADP. H-cytochrome c-reductase activity, and inhibition of liver monooxygenases (aniline hydroxylase, ethylmorphine-N-demethylase, amidopyrine-N-demethylase and analgin-N-demethylase). These effects were most pronounced on the 7th day after virus inoculation as compared to the 5th one. Supplementation of mice with vitamin E before virus inoculation leads to liver protection against oxidative stress and toxicosis. A marked decrease of lipid peroxidation products and an increase of cytochrome P-450 and activities of monooxygenases was established. The stabilizing effect of vitamin E was dose-dependent and was most pronounced on the 5th day after virus inoculation as compared to the 7th one.
authors.affiliation: Department of Medical Physics and Biophysics, Medical University, 2 Zdrave Str., Sofia, Bulgaria.
authors.forename: M
authors.initials: M
authors.lastname: Mileva
authors.forename: L
authors.initials: L
authors.lastname: Tancheva
authors.forename: R
authors.initials: R
authors.lastname: Bakalova
authors.forename: A
authors.initials: A
authors.lastname: Galabov
authors.forename: V
authors.initials: V
authors.lastname: Savov
authors.forename: S
authors.initials: S
authors.lastname: Ribarov
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004177:Dipyrone / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005037:Ethylmorphine-N-Demethylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D009980:Influenza A virus / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000821:virology; D008297:Male; D051379:Mice; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000201:enzymology*; D018384:Oxidative Stress / Q000187:drug effects; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D004177:Dipyrone; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase; D005037:Ethylmorphine-N-Demethylase; C019666:amidopyrine N-demethylase; D009251:NADPH-Ferrihemoprotein Reductase