title: The influence of stiffness of the fixator on maturation of callus after segmental transport.
abstract: The treatment of large bony defects by callus distraction is well accepted, but the duration of treatment is long and the rate of complications increases accordingly. We have examined the effect of the stiffness of the axial fixator on reducing the time for maturation of callus. We created a mid-diaphyseal defect of 15 mm in the metatarsal bone in sheep and stabilised it with a ring fixator. After four days a bony segment was transported for 16 days at 1 mm per day. After 64 days the animals were divided into four groups, three with axial interfragmentary movement (IFM) of 0.5, 1.2 and 3.0 mm, respectively, and a control group. The 3.0 mm IFM group had the smallest bone density (p = 0.001) and area of callus and the largest IFM after 12 weeks; it also had typical clinical signs of hypertrophic nonunion. The most rapid stiffening of the callus was in the 0.5 mm group which had the smallest IFM (p = 0.04) after 12 weeks and radiological signs of bridging of the defect. These results indicate that suitable dynamic axial stimulation can enhance maturation of distraction callus when the initial amplitude is small, but that a large IFM can lead to delayed union.
authors.affiliation: Department of Orthopaedic Research and Biomechanics, University of Ulm, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Claes
authors.forename: J
authors.initials: J
authors.lastname: Laule
authors.forename: K
authors.initials: K
authors.lastname: Wenger
authors.forename: G
authors.initials: G
authors.lastname: Suger
authors.forename: U
authors.initials: U
authors.lastname: Liener
authors.forename: L
authors.initials: L
authors.lastname: Kinzl
mesh_terms: D000818:Animals; D002146:Bony Callus / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005592:Fracture Fixation / Q000295:instrumentation* / Q000379:methods*; D012756:Sheep; D013997:Time Factors; D014057:Tomography, X-Ray Computed