Gene therapy of pediatric leukemia.
Gene therapy approaches offer the possibility of adding a treatment modality that is non-cross-reactive with chemotherapy to the therapeutic options for children with leukemia. Current strategies under evaluation in preclinical models include modification of leukemia cells to decrease tumorogenicity or increase immunogenicity and gene transfer to immune system cells to enhance immune function. Some of these approaches are now being evaluated in clinical trials.
Heslop
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Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. hheslop@bcm.tmc.edu
D002648:Child; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism