title: Assessing the potential carcinogenic activity of magnetic fields using animal models.
abstract: We update our 1997 publication by reviewing 29 new reports of tests of magnetic fields (MFs) in six different in vivo animal models of carcinogenesis: 2-year, lifetime, or multigeneration exposure studies in rats or mice; and promotion/progression models (rat mammary carcinoma, rat liver focus, mouse skin, several models of human leukemia/lymphoma in rats and mice, and brain cancer in rats). Individual experiments are evaluated using a set of data quality criteria, and summary judgments are made across multiple experiments by applying a criterion of rough reproducibility. The potential for carcinogenicity of MFs is discussed in light of the significant body of carcinogenesis data from animal bioassays that now exists. Excluding abstracts, approximately 80% of the 41 completed studies identified in this and our previous review roughly satisfy data quality criteria. Among these studies, the criterion for independent reproducibility is not satisfied for any positive results but is satisfied for negative results in chronic bioassays in rats and mice and for negative results in both promotion and co-promotion assays using the SENCAR mouse skin model. Results of independent replication studies using the rat mammary carcinoma model were conflicting. We conclude that long-term exposure to continuous 50- or 60-Hz MFs in the range of 0.002-5 mT is unlikely to result in carcinogenesis in rats or mice. Though results of most promotion/progression assays are negative, a weak promoting effect of MFs under certain exposure conditions cannot be ruled out based on available data.
authors.affiliation: Electric Power Research Institute, Palo Alto, California, USA. jmccann@xpressweb.com
authors.forename: J
authors.initials: J
authors.lastname: McCann
authors.forename: R
authors.initials: R
authors.lastname: Kavet
authors.forename: C N
authors.initials: CN
authors.lastname: Rafferty
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004574:Electromagnetic Fields / Q000009:adverse effects*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D015203:Reproducibility of Results; D018570:Risk Assessment