Transfusion associated graft-versus-host disease, cytomegalovirus infection and HLA alloimmunization in neonatal and pediatric patients.
Modern transfusion support of pediatric patients requires attention to the necessity to provide specialized or modified blood components to these patients who are often immunocompromised and/or affected by very complex medical and surgical illnesses. In this review we will address three potential complications of transfusion that may require specialized components for their prevention in selected patients namely transfusion-associated graft-versus-host disease, transfusion-transmitted cytomegalovirus infection and HLA alloimmunization, with particular reference to the indications for prevention of these transfusion complications in neonatal and pediatric patients.
Hume
H A
HA
Department of Pediatrics, Université de Montréal, Québec, Canada. humeh@medclin.umontreal.ca
Preiksaitis
J B
JB
D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control*; D006680:HLA Antigens / Q000009:adverse effects*; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D007231:Infant, Newborn; D007518:Isoantibodies / Q000009:adverse effects; D008297:Male; D011247:Pregnancy; D065227:Transfusion Reaction
D006680:HLA Antigens; D007518:Isoantibodies