Protective effect of capsaicin on the osmotic fragility of human erythrocytes.
Capsaicin exerts a stabilizing effect on erythrocytes making them more resistant to lysis under hypotonic stress. The protective action of capsaicin on osmotic fragility (OF) was not receptor mediated since no dose responsive effect was observed. The results suggest that this protective effect of capsaicin on OF is due to a direct interaction of capsaicin with the erythrocyte membrane rather than due to any alteration in the intracellular metabolism of erythrocytes.
Rizvi
S I
SI
Department of Biochemistry, University of Allahabad, India.
Srivastava
P P
PP
D000328:Adult; D002211:Capsaicin / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006801:Humans; D009997:Osmotic Pressure; D012016:Reference Values
D002211:Capsaicin