title: [Cerebral magnetic resonance imaging (MRI) in the diagnosis of leptomeningeal carcinomatosis in melanoma patients].
abstract: OBJECTIVE
  Meningeal involvement is frequent in metastatic melanoma, approximately 30% in autopsy series. Functional signs may be misleading and the neurological examination may be normal. Certain diagnosis requires identification of tumor cells in the cerebrospinal fluid. CSF cytology is however sometimes negative and magnetic resonance imaging (MRI) with gadolinium injection may provide the diagnosis. The aim of this retrospective study was to assess the role of imaging in the diagnosis of leptomeningeal carcinomatosis.
  
  
  METHODS
  The diagnosis of leptomeningeal carcinomatosis was made in 8 patients between 1992 and 1998. All had signs of neurological function impairment, but the neurology examination was abnormal in only 2.
  
  
  RESULTS
  Cytology examination of the cerebrospinal fluid provided the diagnosis of leptomeningeal carcinomatosis in 5 patients. One out of 5 brain CT scans were positive, showing meningeal enhancement confirmed by brain MRI. The spinal tap was not contributive in 2 cases and was not done in 1. In these three cases, the brain CT did not provide any diagnostic element while the brain MRI with gadolinium injection confirmed the diagnosis of leptomeningeal carcinomatosis.
  
  
  CONCLUSIONS
  Forty-one percent of patients with autopsy proven leptomeningeal carcinomatosis have a normal ante mortem spinal tap. Brain MRI with gadolinium injection has better sensitivity than brain CT scan. All patients with nonspecific neurological signs and a normal spinal tap should be explored with a brain MRI.
authors.affiliation: Services de Dermatologie, Institut Gustave-Roussy, 94805 Villejuif Cedex.
authors.forename: F
authors.initials: F
authors.lastname: Dupuis
authors.forename: R
authors.initials: R
authors.lastname: Sigal
authors.forename: A
authors.initials: A
authors.lastname: Margulis
authors.forename: S
authors.initials: S
authors.lastname: Mercier
authors.forename: A
authors.initials: A
authors.lastname: Spatz
authors.forename: G
authors.initials: G
authors.lastname: Mamelle
authors.forename: E
authors.initials: E
authors.lastname: Lartigau
authors.forename: P
authors.initials: P
authors.lastname: Duvillard
authors.forename: M F
authors.initials: MF
authors.lastname: Avril
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008581:Meningitis / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D008875:Middle Aged; D009300:Nasal Septum; D009669:Nose Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology; D013997:Time Factors; D014057:Tomography, X-Ray Computed