The role of SLP-76 and LAT in lymphocyte development.
SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRbeta locus.
Pivniouk
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Division of Immunology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. pivniouk@a1.tch.harvard.edu
Geha
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D048868:Adaptor Proteins, Signal Transducing; D000483:Alleles; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002454:Cell Differentiation; D019070:Cell Lineage; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D005246:Feedback; D018507:Gene Expression Regulation, Developmental; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006410:Hematopoiesis; D006801:Humans; D008213:Lymphocyte Activation; D008565:Membrane Proteins; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D010750:Phosphoproteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D016176:T-Lymphocyte Subsets / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology; D019076:Transgenes; D045567:VDJ Recombinases
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C110810:LAT protein, human; C491734:Lat protein, mouse; D008565:Membrane Proteins; D010750:Phosphoproteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; C092947:SLP-76 signal Transducing adaptor proteins; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases