title: Evaluation of skeletal muscle metabolism and response to erythropoietin treatment in patients with chronic renal failure using 99Tcm-sestamibi leg scintigraphy.
abstract: It is well known that uraemia affects skeletal muscle metabolism. This has been attributed to a variety of causes, including anaemia, vitamin D, carnitine deficiency and hyperparathyroidism. The aim of this study was to ascertain whether 99Tcm-sestamibi leg scintigraphy is useful in the evaluation of skeletal muscle metabolism and the monitoring of treatment response in uraemic myopathy. Forty patients with chronic renal failure and 24 normal controls underwent examination. Fifteen patients with chronic renal failure received erythropoietin treatment. 99Tcm-sestamibi leg scintigraphy was performed in all subjects and in 15 patients after therapy. The calf-to-ankle uptake ratio was calculated by semi-quantitative analysis and normalized to lean body mass. The normalized uptake ratios were significantly different between patients and controls. After erythropoietin therapy, there was a significant increase in the normalized uptake ratios compared with pre-therapy. Our results suggest that 99Tcm-sestamibi leg scintigraphy is useful in the assessment of muscle metabolic abnormalities and the effect of treatment in uraemic myopathy.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sarikaya
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: T F
authors.initials: TF
authors.lastname: Cermik
authors.forename: M
authors.initials: M
authors.lastname: Birtane
authors.forename: S
authors.initials: S
authors.lastname: Berkarda
mesh_terms: D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D007866:Leg / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging* / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D017256:Technetium Tc 99m Sestamibi; D014463:Ultrasonography
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D004921:Erythropoietin; D017256:Technetium Tc 99m Sestamibi