title: [In vitro activities of carbapenem antibiotics against the various clinical isolates].
abstract: The annual changes of antibacterial activities of beta-lactam antibiotics, mainly carbapenem antibiotics, were investigated against 5 bacterial species, S. aureus (MSSA), methicillin-resistant S. aureus (MRSA), Klebsiella pneumoniae, Serratia marcescens, Pseudomonas aeruginosa, which had been isolated from the clinical materials at Toho University Omori Hospital during the period of 1995 to 1997. In addition, antibacterial activities against other main bacterial strains isolated from the clinical materials during 1997 were also determined. The five bacterial species on which annual changes of the sensitivity were investigated did not show any remarkable trend to increase in resistance to the carbapenem antibiotics tested. The antibacterial activities of the carbapenem antibiotics against MRSA were weak, and MIC90 values were between 25 and 50 micrograms/ml. In S. marcescens and P. aeruginosa on which high resistance by the production of metallo-beta-lactamase has become a problem in recent years, there were no remarkable changes in annual changes of sensitivities. Especially, MIC90 valuses of the carbapenem antibiotics against P. aeruginosa were between 12.5 and 25 micrograms/ml, 4 to 8 times better than that of PIPC, like the case of CAZ. Furthermore, the carbapenem antibiotics showed strong antibacterial activities against clinically important 16 bacterial species, from Gram-positive to Gram-negative bacteria.
authors.affiliation: Department of Laboratory Medicine, Toho University Omori Hospital.
authors.forename: F
authors.initials: F
authors.lastname: Kashitani
authors.forename: S
authors.initials: S
authors.lastname: Fukuzawa
authors.forename: C
authors.initials: C
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Yasui
authors.forename: S
authors.initials: S
authors.lastname: Yumoto
authors.forename: M
authors.initials: M
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Iwata
authors.forename: K
authors.initials: K
authors.lastname: Tateda
authors.forename: S
authors.initials: S
authors.lastname: Miyazaki
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
mesh_terms: D015780:Carbapenems / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000302:isolation & purification; D016106:Methicillin Resistance; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012706:Serratia marcescens / Q000187:drug effects* / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D015780:Carbapenems