The effect of orally administered cisapride on intestinal motility in conscious horses.
Seven Thoroughbred horses were laparotomized and Force Transducers were fixed on the proximal jejunal and cecal serosa. After observation of the digestive tract motility in consciousness, cisapride (0, 0.5, 0.75 or 1 mg/kg) was orally administered. In horses treated with 0.75 mg/kg or 1.0 mg/kg cisapride, the migrating contraction (MC) of the jejunum was significantly increased in frequency.
Sasaki
N
N
Equine Research Institute, Japan Racing Association, Utsunomiya-city, Tochigi.
Yoshihara
T
T
D000284:Administration, Oral; D000818:Animals; D002432:Cecum / Q000187:drug effects; D020117:Cisapride / Q000008:administration & dosage / Q000494:pharmacology*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006736:Horses / Q000502:physiology*; D007583:Jejunum / Q000187:drug effects; D008297:Male
D005765:Gastrointestinal Agents; D020117:Cisapride