Cortical development: receiving reelin.
Recent genetic and biochemical studies indicate that lipoprotein receptors are components of the neuronal receptor for Reelin, mediating the glycoprotein's essential function in cortical development. At least eight cadherin-related neuronal receptors may also play a part in this signalling system.
Gilmore
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Department of Neuroscience, Case Western Reserve University Medical School/University Hospitals of Cleveland, Cleveland, Ohio 44106, USA. kxh26@po.cwru.edu
Herrup
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D000818:Animals; D053329:Apolipoprotein E2; D001057:Apolipoproteins E / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D051379:Mice; D008818:Mice, Neurologic Mutants; D019579:Neocortex / Q000196:embryology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism; D000091363:Protocadherins; D011956:Receptors, Cell Surface; D000091042:Reelin Protein; D012697:Serine Endopeptidases
D053329:Apolipoprotein E2; D001057:Apolipoproteins E; D015820:Cadherins; D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D008079:Lipoproteins, VLDL; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C113143:Pcdha4 protein, mouse; D000091363:Protocadherins; D011956:Receptors, Cell Surface; D000091042:Reelin Protein; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases