title: Do glucocorticoids cause spinal epidural lipomatosis? When endocrinology and spinal surgery meet.
abstract: Here, we report pathogenetic aspects of spinal epidural lipomatosis (SEL) based on a literature review. SEL is a rare entity but can cause significant morbidity. Its symptoms can be identical to those of more common disorders such as vertebral and disc disease, and cord lesions (for example, transverse myelitis, multiple sclerosis and syringomyelia). Therefore, it often goes undiagnosed. In addition, SEL occurs in patients on glucocorticoid therapy, which can lead to myopathy, thereby mimicking the motor symptoms of SEL. Glucocorticoids seem to play a major role in the development of SEL, although idiopathic SEL has also been reported. The latter occurs almost exclusively in obese individuals who may have concurrent hypercortisolism. Once clinically suspected, SEL is best diagnosed by magnetic resonance imaging (MRI). Treatment of SEL is directed at reducing body weight in patients with idiopathic SEL, and at decreasing glucocorticoid excess in patients with endogenous or exogenous hypercortisolism. In severe cases, decompressive laminectomy might become necessary to alleviate the neurological symptoms caused by spinal cord compression.
authors.affiliation: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Koch
authors.forename: J L
authors.initials: JL
authors.lastname: Doppman
authors.forename: N J
authors.initials: NJ
authors.lastname: Patronas
authors.forename: L K
authors.initials: LK
authors.lastname: Nieman
authors.forename: G P
authors.initials: GP
authors.lastname: Chrousos
mesh_terms: D004824:Epidural Space; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D008068:Lipomatosis / Q000139:chemically induced* / Q000628:therapy; D013118:Spinal Cord Diseases / Q000139:chemically induced*
chemical_list: D005938:Glucocorticoids