title: Synthesis and evaluation of daunorubicin-paclitaxel dimers.
abstract: Bifunctional, heterodimeric compounds were synthesized to test their ability to create polyvalent arrays between DNA and microtubules in cells. Each dimer was examined for the capacity to bind to microtubules and for cytotoxicity against MES-SA and MES-SA/Dx5 cell lines.
authors.affiliation: Department of Chemistry, Stanford University, CA 94305-5080, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Kar
authors.forename: P D
authors.initials: PD
authors.lastname: Braun
authors.forename: T J
authors.initials: TJ
authors.lastname: Wandless
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003630:Daunorubicin / Q000737:chemistry* / Q000494:pharmacology; D019281:Dimerization; D004354:Drug Screening Assays, Antitumor; D017239:Paclitaxel / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D017239:Paclitaxel; D003630:Daunorubicin