title: Polyhydroxylated pyrrolidine and piperidine alkaloids from Adenophora triphylla var. japonica (Campanulaceae).
abstract: Adenophora triphylla var. japonica (Campanulaceae) yielded two new alkaloids, the 6-C-butyl derivative of 2R,5R-bis(hydroxymethyl)-3R,4R-dihydroxypyrrolidine (DMDP) and alpha-1-C-ethyl-fagomine, together with the known alkaloids 1,4-dideoxy-1,4-imino-D-arabinitol, 1-deoxynojirimycin, and 1-deoxymannojirimycin. 6-C-Butyl-DMDP showed inhibitory activity toward almond beta-glucosidase (IC50 = 68 microM), whereas alpha-1-C-ethyl-fagomine inhibited bovine liver beta-galactosidase (IC50 = 29 microM).
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. naoki22@po.incl.ne.jp
authors.forename: N
authors.initials: N
authors.lastname: Asano
authors.forename: M
authors.initials: M
authors.lastname: Nishida
authors.forename: M
authors.initials: M
authors.lastname: Miyauchi
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Kizu
authors.forename: Y
authors.initials: Y
authors.lastname: Kameda
authors.forename: A A
authors.initials: AA
authors.lastname: Watson
authors.forename: R J
authors.initials: RJ
authors.lastname: Nash
authors.forename: G W
authors.initials: GW
authors.lastname: Fleet
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification*; D010944:Plants / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000470:Alkaloids; D010880:Piperidines; D011759:Pyrrolidines