Cytochrome c release from mitochondria: all or nothing.
During the process of apoptosis, cytochrome c is released from mitochondria into the cytosol where it helps to activate the caspases, a family of killer proteases. The release of cytochrome c is a rapid, complete and kinetically invariant event.
Martinou
J C
JC
Desagher
S
S
Antonsson
B
B
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000502:physiology; D003574:Cytochrome c Group / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology*; D006367:HeLa Cells; D006801:Humans; D007425:Intracellular Membranes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology*; D008954:Models, Biological
D003574:Cytochrome c Group; D020169:Caspases