Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice.
The expression of cyclooxygenase-2 (COX-2) and striatal dopamine (DA) depletion in BALB/cAnNcrj (BALB/c) mice following a neurotoxic dose of methamphetamine (METH) was investigated. METH-treatment (4 mg/kg x 4, 2 h intervals, s.c.) induced a significant hyperthermia and a persistent depletion of striatal DA levels 72 h after the treatment. COX-2, a marker of the cytotoxic effect of inflammation and oxidative stress and thiobarbituric acid (TBA) were significantly induced in the striatum 72 h after the METH-treatment, but not in the hippocampus. These results suggest that COX-2 may participate in METH-induced neurotoxicity in striatum.
Kita
T
T
Department of Pharmacology, Nara Medical University, Kashihara, Japan. tkita@naramed-u.ac.jp
Shimada
K
K
Mastunari
Y
Y
Wagner
G C
GC
Kubo
K
K
Nakashima
T
T
D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D051546:Cyclooxygenase 2; D004298:Dopamine / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology*; D007527:Isoenzymes / Q000187:drug effects* / Q000378:metabolism; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects* / Q000378:metabolism; D013858:Thiobarbiturates / Q000378:metabolism*
D015259:Dopamine Agents; D007527:Isoenzymes; D013858:Thiobarbiturates; D008694:Methamphetamine; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; C029684:thiobarbituric acid; D004298:Dopamine