Potential of recombinant human bone morphogenetic protein-2 in bone regeneration.
Recombinant human bone morphogenetic protein (rhBMP-2) has been used as a bone substitute. This article describes the rhBMP-2 structure, mechanisms of action, carriers, advantages, safety, and recent clinical studies relevant to dentistry.
Barboza
E
E
Universidade Federal Fluminense, Rio de Janeiro, Brazil. carlosbz@uol.com.br
Caúla
A
A
Machado
F
F
D016301:Alveolar Bone Loss / Q000188:drug therapy; D000818:Animals; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D001861:Bone Regeneration / Q000187:drug effects*; D004337:Drug Carriers; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D016212:Transforming Growth Factor beta
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D004337:Drug Carriers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2