title: Effect of prolonged asphyxia on skin blood flow in fetal lambs.
abstract: OBJECTIVE
  To determine the effect of a prolonged period of asphyxia on skin blood flow, a potential indicator of fetal cardiovascular responses to asphyxia, in the chronically catheterized fetal lamb.
  
  
  METHODS
  Eight chronically instrumented pregnant ewes were studied at 118 +/- 1 days' gestation. After a control period, fetal acid-base status was assessed and regional blood flows were determined with dye-labeled microspheres. Fetal asphyxia was then induced by partial umbilical cord occlusion, decreasing fetal arterial oxygen pressure to 15 torr while maintaining pH above 7.28. Fetal cardiovascular status was monitored continuously. Fetal acid base status was evaluated every 10-15 minutes during cord occlusion. Regional blood flow determinations were repeated after 90 minutes of stable asphyxia. Results are expressed as the mean +/- standard error. Student t test for paired data was used to compare hemodynamic, acid-base, and regional blood flow determinations before cord occlusion and after 90 minutes of asphyxia.
  
  
  RESULTS
  There was a significant increase in blood flow to the fetal scalp from a control value of 52 +/- 8 mL per minutes per 100 g to 175 +/- 30 mL per minute per 100 g at 90 minutes of asphyxia (P =.01). Similarly, there was an increase in blood flow to the skin overlying the fetal hindquarter from 39 +/- 12 mL per minute per 100 g during control to 153 +/- 47 mL per minute per 100 g at asphyxia (P =.038).
  
  
  CONCLUSIONS
  In the chronically instrumented fetal lamb, a 90-minute period of asphyxia produced by partial cord occlusion resulted in a significant increase in blood flow to the fetal skin.
authors.forename: P D
authors.initials: PD
authors.lastname: Bobby
authors.forename: A C
authors.initials: AC
authors.lastname: Santos
mesh_terms: D000818:Animals; D001237:Asphyxia; D005260:Female; D005333:Fetus / Q000098:blood supply* / Q000502:physiology; D006340:Heart Rate, Fetal; D011247:Pregnancy; D012039:Regional Blood Flow; D012756:Sheep; D012867:Skin / Q000098:blood supply* / Q000196:embryology*; D013997:Time Factors