In vitro activities of sitafloxacin (DU-6859a) and six other fluoroquinolones against 8,796 clinical bacterial isolates.
The in vitro activities of sitafloxacin, ciprofloxacin, trovafloxacin, levofloxacin, clinafloxacin, gatifloxacin, and moxifloxacin against 5,046 gram-negative bacteria, 3,344 gram-positive cocci, and 406 anaerobes were determined. Sitafloxacin was the most active agent against gram-positive cocci and anaerobes. Against Enterobacteriaceae and nonfermenters, its activity was either equivalent to or better than that of clinafloxacin.
Milatovic
D
D
Eijkman-Winkler Institute for Microbiology, Infectious Diseases & Inflammation, University Hospital Utrecht, Utrecht, The Netherlands. d.milatovic@lab.azu.nl
Schmitz
F J
FJ
Brisse
S
S
Verhoef
J
J
Fluit
A C
AC
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology*; D015169:Colony Count, Microbial; D024841:Fluoroquinolones; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C076246:sitafloxacin