title: Brachytherapy optimal planning with application to intravascular radiation therapy.
abstract: We have been studying brachytherapy planning with the objective of minimizing the maximum deviation of the delivered dose from prescribed dose bounds for treatment volumes. A general framework for optimal treatment planning is presented and the minmax optimization is formulated as a linear program. Dose rate calculations are based on the dosimetry formulation of the American Association of Physicists in Medicine, Task Group 43. We apply the technique to optimal planning for intravascular brachytherapy of intimal hyperplasia using ultrasound data and 192Ir seeds. The planning includes determination of an optimal dwell-time sequence for a train of seeds that deliver radiation while stepping through the vessel lesion. The results illustrate the advantage of this strategy over the common approach of delivering radiation by positioning a single train of seeds along the whole lesion.
authors.affiliation: Computer Science Department, Johns Hopkins University, Baltimore, MD 21218, USA. ps@cs.jhu.edu
authors.forename: P
authors.initials: P
authors.lastname: Sadegh
authors.forename: F A
authors.initials: FA
authors.lastname: Mourtada
authors.forename: R H
authors.initials: RH
authors.lastname: Taylor
authors.forename: J H
authors.initials: JH
authors.lastname: Anderson
mesh_terms: D000465:Algorithms; D001918:Brachytherapy / Q000379:methods*; D003198:Computer Simulation; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D006965:Hyperplasia / Q000532:radiotherapy; D008955:Models, Cardiovascular; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012008:Recurrence; D013499:Surface Properties; D017539:Tunica Intima / Q000473:pathology; D014463:Ultrasonography