Identification of the novel allele HLA-B*1546 which belongs to the serological B72 type: implications for bone marrow transplantation.
The identification of the novel allele HLA-B*1546, which has serological B50 and B72 reactivity, was found in two members of a family of Turkish origin. In the sequence analysis the new allele differs from B*1501 by four nucleotides in exon 2. Its structure suggests that it may have originated by gene conversion with B*40, B*41, B*44, B*4501, B*47, B*4901 or B*50. At the protein level, the new allele has three amino acid differences compared to B*1501. Sequence alignment demonstrates that amino acid residue 46 is crucial for serological B72 reactivity. Due to substantial differences with other B*15 variants a possible mismatch may impair clinical outcome of bone marrow transplantation.
Elsner
H A
HA
Department of Transfusion Medicine, Hannover Medical School, Germany.
Wölpl
A
A
Goldmann
S F
SF
Blasczyk
R
R
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001788:Blood Grouping and Crossmatching; D016026:Bone Marrow Transplantation / Q000276:immunology*; D005260:Female; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology*; D059910:HLA-B15 Antigen; D006801:Humans; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation; D011110:Polymorphism, Genetic; D016511:Severe Combined Immunodeficiency / Q000628:therapy*
D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D007519:Isoantigens