Stability study of piroxicam and cinnoxicam in solid pharmaceuticals.
The pseudo-first order rate constant for the hydrolysis of cinnoxicam as a function of temperature was obtained by variable-temperature kinetic experiments. The method used is on a generalization of non-isothermal analysis, and takes advantage of the capabilities of modern data collection and processing systems. A spectrophotometric method under non isothermal conditions was carried out. The results obtained are identical to those obtained under the same conditions by using traditional constant-temperature kinetic runs. This provides the possibility of reducing the amount of time spent and chemicals usually used in collecting kinetic data in mechanistic studies in solution by an order of magnitude.
Ficarra
R
R
Dipartimento Farmaco-Chimico, Università di Messina, Facoltà di Farmacia, Italy. pficarra@pharma.unime.it
Villari
A
A
Micali
N
N
Tommasini
S
S
Calabrò
M L
ML
Di Bella
M R
MR
Melardi
S
S
Agresta
M F
MF
Coppolino
S
S
Stancanelli
R
R
D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006868:Hydrolysis; D007700:Kinetics; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000032:analysis; D012996:Solutions; D013696:Temperature
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D012996:Solutions; D010894:Piroxicam; C057291:piroxicam cinnamate