title: Diabetic nephropathy accompanied by iodine-induced non-autoimmune primary hypothyroidism: two case reports.
abstract: We reported 2 diabetic patients with nephrotic syndrome due to advanced diabetic nephropathy complicated by non-autoimmune primary hypothyroidism. Hypothyroidism developed along with the anasarcous status. Histological examinations of the thyroid gland revealed almost normal thyroid follicles without lymphocytic infiltration. The amounts of thyroid hormone lost into the extravascular space such as in urine and ascites were not sufficient to cause hypothyroidism alone. Serum total iodine levels measured during the hypothyroidal state in both cases were definitely elevated, and the perchlorate discharge test of both cases showed positive discharge (24 and 34%, respectively). The thyroid functions normalized after iodine restriction in the first case and initiating hemodialysis in the second case, in parallel with normalization of serum total iodine levels. These findings suggest that impaired renal handling of iodine resulting in elevation of serum iodine levels, rather than an autoimmune mechanism or extravascular hormone loss, played a principal role in the development of primary hypothyroidism found in these 2 patients, probably through a prolonged Wolff-Chaikoff effect.
authors.affiliation: Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan.
authors.forename: U
authors.initials: U
authors.lastname: Bando
authors.forename: Y
authors.initials: Y
authors.lastname: Ushiogi
authors.forename: D
authors.initials: D
authors.lastname: Toya
authors.forename: N
authors.initials: N
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Fujisawa
mesh_terms: D000368:Aged; D001201:Ascites / Q000000981:diagnostic imaging / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000150:complications*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D007455:Iodine / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications*; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology; D013963:Thyroid Hormones / Q000378:metabolism / Q000652:urine; D014057:Tomography, X-Ray Computed
chemical_list: D013963:Thyroid Hormones; D007455:Iodine