title: Uncoating kinetics of hepatitis A virus virions and provirions.
abstract: When the growth kinetics of immature hepatitis A virus provirions and mature virions were monitored, distinct eclipse phases were noted for both types of particles. Strikingly, uncoating of virions occurred around 4 h postinfection, while uncoating of provirions occurred predominantly between 8 and 10 h postinfection. It is proposed that the heterogeneous mixture of infectious hepatitis A virus particles (virions and provirions) typically present in inocula is responsible for the normally asynchronous nature of hepatitis A virus uncoating kinetics.
authors.affiliation: Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research, Fairfield, Victoria, Australia 3078. nebishop@fs2.scg.man.ac.uk
authors.forename: N E
authors.initials: NE
authors.lastname: Bishop
authors.forename: D A
authors.initials: DA
authors.lastname: Anderson
mesh_terms: D006507:Hepatovirus / Q000254:growth & development* / Q000472:pathogenicity / Q000502:physiology; D007700:Kinetics; D011499:Protein Processing, Post-Translational; D014764:Viral Proteins / Q000378:metabolism; D014771:Virion / Q000254:growth & development* / Q000472:pathogenicity
chemical_list: D014764:Viral Proteins