title: Sulphur-containing derivatives structurally related to fenoxycarb are potent growth inhibitors against the intracellular form of Trypanosoma cruzi.
abstract: Sulphur-containing derivatives structurally related to the insect growth regulator fenoxycarb were shown to be extremely active antiproliferative agents against the amastigote form of Trypanosoma cruzi in in vitro assays. All of these drugs had previously been proved to be remarkably potent growth inhibitors against the epimastigote form of the parasite.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, Buenos Aires, Argentina. jbr@qo.fcen.uba.ar
authors.forename: J B
authors.initials: JB
authors.lastname: Rodriguez
authors.forename: R
authors.initials: R
authors.lastname: Docampo
authors.forename: E G
authors.initials: EG
authors.lastname: Gros
mesh_terms: D000818:Animals; D002219:Carbamates / Q000737:chemistry*; D002478:Cells, Cultured; D010647:Phenyl Ethers / Q000737:chemistry / Q000494:pharmacology*; D048448:Phenylcarbamates; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000737:chemistry / Q000494:pharmacology*; D014344:Trypanocidal Agents / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000254:growth & development
chemical_list: D002219:Carbamates; D010647:Phenyl Ethers; D048448:Phenylcarbamates; D013440:Sulfides; D014344:Trypanocidal Agents; C052034:fenoxycarb