Effect of dietary vitamin B6 contents on antibody production.
When mice were placed on diets extreme deficient in vitamin B6, ovalbumin-dependent antibody productions (IgE, IgG1, IgG2a) were significantly suppressed, and alanine aminotransferase activity in the liver was also significantly decreased. In the case of pyridoxine excess (6 mg% = about ten times standard amount) in a 70% casein diet, ovalbumin-dependent antibody productions were also considerably suppressed. These responses were weaker in a low casein (5%) or normal casein (20%) diet than in a 70% casein diet. The administration of high doses of pyridoxine (6 mg%) resulted in the suppression of hepatic cathepsin B activity. Therefore, we conclude that ovalbumin-dependent antibody productions (IgG1, IgE) were suppressed by pyridoxine excess diet (6 mg%), because hepatic cathepsin B activity was suppressed by the excess pyridoxine in diet.
Inubushi
T
T
Faculty of Home Economics, Tokushima Bunri University, Japan.
Okada
M
M
Matsui
A
A
Hanba
J
J
Murata
E
E
Katunuma
N
N
D000818:Animals; D000917:Antibody Formation; D002401:Cathepsin B / Q000378:metabolism; D004032:Diet; D008099:Liver / Q000201:enzymology; D051379:Mice; D011736:Pyridoxine / Q000008:administration & dosage*; D026681:Vitamin B 6 Deficiency / Q000276:immunology*
D002401:Cathepsin B; D011736:Pyridoxine