A-kinase anchoring proteins: protein kinase A and beyond.
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.
Edwards
A S
AS
Howard Hughes Medical Institute, Vollum Institute, Oregon Health Sciences University, Portland, OR 97201, USA.
Scott
J D
JD
D054758:A Kinase Anchor Proteins; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000378:metabolism*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D029589:Seminal Plasma Proteins
D054758:A Kinase Anchor Proteins; C112944:A kinase anchor protein (kap-1), C elegans; C484688:AKAP2 protein, human; C487775:AKAP5 protein, human; C112596:AKAP7 protein, human; C119719:AKAP9 protein, human; D048868:Adaptor Proteins, Signal Transducing; C121679:Akap200 protein, Drosophila; C487791:Akap7 protein, mouse; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; D017868:Cyclic AMP-Dependent Protein Kinases