title: [Clinical or biological symptoms leading to the search for amyloidosis].
abstract: BACKGROUND
  The extracellular, multifocal, disseminated or diffuse localization of amyloidosis accounts for the diversity of clinical presentations and late diagnosis.
  
  
  BACKGROUND
  However, early diagnosis is important, as new drugs have been recently introduced. Both clinical picture and biology help guide diagnosis, including either kidney, heart, skin or neurologic involvement associated with monoclonal gammapathy (primary idiopathic amyloidosis AL); underlying inflammatory or infectious disease, familial Mediterranean fever with proteinuria (secondary amyloidosis AA); cardiac, neurologic or ocular involvement (heredofamilial amyloidosis); carpal tunnel syndrome, joint pain (amyloidosis of hemodialysis). Furthermore, amyloid fibrils are identified on salivary gland biopsy.
  
  
  CONCLUSIONS
  Due to the introduction of new specific drugs aimed at curing various amyloidoses, early diagnosis is important. Chemotherapy and hematopoietic stem cell transplantation are promising regarding AL amyloidosis, while liver transplantation has proven remarkably successful in heredofamilial amyloidosis. Progress in molecular biology should allow identification of various forms of familial amyloidosis.
authors.affiliation: Service de Médecine Interne, Centre Hospitalier Lyon-Sud, Pierre-Bénite, France.
authors.forename: H
authors.initials: H
authors.lastname: Rousset
authors.forename: C
authors.initials: C
authors.lastname: Sauron
authors.forename: R
authors.initials: R
authors.lastname: Barouky
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans