Synthetic analogues of netropsin and distamycin. V. Synthesis of a carbocyclic bis-lexitropsin as potential DNA cleaving agent.
A carbocyclic analogue of bis-distamycin, in which N-methylpyrroles were replaced by two trisubstituted benzene moieties joined by tetramethylenedioxy linkage, has been prepared. This compound bearing photosensitive benzotriazole moieties at the N-terminal residues. The synthetic method for the preparation of the bis-benzotriazolyllexitropsin was accomplished in twelve steps starting from 2-hydroxy-5-phenylazobenzoic acid.
Pućkowska
A
A
Department of Organic Chemistry, Medical Academy of Białystok.
Bartulewicz
D
D
Markowska
A
A
Zwierz
K
K
Rózański
A
A
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D000998:Antiviral Agents / Q000737:chemistry*; D002455:Cell Division; D004214:Distamycins / Q000737:chemistry*; D006801:Humans; D009429:Netropsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004214:Distamycins; C053654:lexitropsin; D009429:Netropsin; C030000:stallimycin