Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy.
Immunologists are already comfortable with the need for monitoring many different gene products simultaneously. It is a common challenge to remember what CD-one-hundred-and-something is, and an ever-increasing number of colours are required for identification on the flow cytometer. Gene expression arrays now offer the possibility of extending this approach beyond the cell surface and expanding it dramatically to survey the entire catalogue of gene transcripts in a lymphoid cell.
Glynne
R J
RJ
Eos Biotechnology, South San Francisco, 94080, USA.
Ghandour
G
G
Goodnow
C C
CC
D000465:Algorithms; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D016477:Artifacts; D002469:Cell Separation; D016000:Cluster Analysis; D003627:Data Interpretation, Statistical; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008223:Lymphoma / Q000235:genetics / Q000473:pathology; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D012334:RNA, Neoplasm / Q000096:biosynthesis / Q000235:genetics; D013045:Species Specificity
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D012333:RNA, Messenger; D012334:RNA, Neoplasm