title: [Hyperhomocysteinemia and arterial or venous thrombosis. Retrospective study of 75 cases].
abstract: OBJECTIVE
  Previous studies suggest that hyperhomocysteinemia may be a risk factor for arterial and venous thrombosis. We retrospectively analyzed data from 75 patients with thrombosis.
  
  
  METHODS
  Thirty-four patients had arterial thrombosis, 22 venous thrombosis and 19 venous and arterial thrombosis. Of the 75 patients (49 men and 26 women, mean age 49 +/- 15 years) about two-thirds had recurrent episodes of thrombosis.
  
  
  RESULTS
  Hyperhomocysteinemia was defined as serum homocysteine level above 14.1 mumol/l (mean + 2.7 SD in healthy subjects) and was found in 67 patients (89%, CI95% = 80-95). Mean total homocysteine concentration was 21.6 +/- 13.6 mumol/l for the 75 patients. About half of the patients were smokers, 35% had hypertension and 25% high serum cholesterol. There was no significant relationship between serum homocysteine level and smoking status, hypertension or serum cholesterol level. Ten patients (13%, CI95% = 7-23) had low serum cobalamin (< 150 pmol/l). Serum folates were < or = 10 nmol in 41% of the patients in the arterial thrombosis group (CI95% = 25-59), in 27% in the venous thrombosis group (CI95% = 11-50), and in 31% in the arterial and venous thrombosis group (CI95% = 13-57). Thirteen patients received vitamin B supplementation. Hyperhomocysteinemia decreased in 12/13 patients (CI95% = 64-100) and returned to normal values in 9/13 patients (69%, CI95% = 38-91).
  
  
  CONCLUSIONS
  Our data show that hyperhomocysteinemia is frequently found in arterial and venous thrombosis. Further studies are needed to determine the clinical impact of homocysteine lowering therapy.
authors.affiliation: Laboratoire de Biochimie C, Groupe hospitalier Pitié-Salpêtrière, Paris.
authors.forename: N
authors.initials: N
authors.lastname: Jacob
authors.forename: P
authors.initials: P
authors.lastname: Cacoub
authors.forename: P
authors.initials: P
authors.lastname: Hausfater
authors.forename: Z
authors.initials: Z
authors.lastname: Tazi
authors.forename: S
authors.initials: S
authors.lastname: Hamidou
authors.forename: P
authors.initials: P
authors.lastname: Godeau
authors.forename: M J
authors.initials: MJ
authors.lastname: Foglietti
authors.forename: J C
authors.initials: JC
authors.lastname: Piette
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D014805:Vitamin B 12 / Q000008:administration & dosage
chemical_list: D006710:Homocysteine; D014805:Vitamin B 12