title: Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity.
abstract: Dynamic susceptibility contrast-enhanced magnetic resonance (MR) imaging in tumors is restricted by relaxivity effects, which may obscure any abnormality of first-pass kinetics in the re-circulation phase. The purposes of this study were a) to document the magnitude of relaxivity effects with a variety of commonly used MR susceptibility imaging techniques; and b) to determine whether the re-circulation phase of the first-pass curve in tumors differs from that in normal tissue. We have confirmed that residual relaxivity effects can be eliminated from dynamic susceptibility contrast-enhanced data by several techniques. Application of these methods to enhancing vascular tumors allows detection of abnormalities in the re-circulation phase, which would otherwise be obscured. These abnormalities are independent of relative cerebral blood volume (rCBV) and presumably represent deviations from the predicted gamma variat flow pattern seen in normal tissues. We believe that the parameter rR described here provides an indicator of the chaotic nature of neovascular angiogenesis, which may be of benefit in diagnosis and management.
authors.affiliation: Philips Medical Systems, Hammersmith, London, United Kingdom. ak@medphysics.leeds.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Kassner
authors.forename: D J
authors.initials: DJ
authors.lastname: Annesley
authors.forename: X P
authors.initials: XP
authors.lastname: Zhu
authors.forename: K L
authors.initials: KL
authors.lastname: Li
authors.forename: I D
authors.initials: ID
authors.lastname: Kamaly-Asl
authors.forename: Y
authors.initials: Y
authors.lastname: Watson
authors.forename: A
authors.initials: A
authors.lastname: Jackson
mesh_terms: D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000098:blood supply / Q000473:pathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D019786:Gadolinium DTPA