title: The results of ingredient patch testing in contact dermatitis elicited by povidone-iodine preparations.
abstract: 10 cases of contact dermatitis which began during the application of povidone-iodine preparations were examined with patch tests using 2 kinds of povidone-iodine preparations and their ingredients, i.e., povidone-iodine, polyoxyethylene nonylphenyl ether and glycerin, and also the components of povidone-iodine, i.e., iodine and polyvinylpyrrolidone. All 10 cases reacted positively to the povidone-iodine preparations and povidone-iodine, 3 out of the 10 to polyoxyethylene nonylphenyl ether, 1 out of the 9 tested to iodine, while no positive response was found to glycerin or polyvinyl-pyrrolidone. It was difficult to distinguish between allergic responses from irritation, as responses to patches of povidone-iodine and its preparations usually include irritation at high frequencies. Based on comparison of results with a control group, however, those showing + or stronger reactions to 2% povidone-iodine at days 3 to 5 were considered to be allergic. Thus, 4 out of the 10 cases were considered as sensitization to povidone-iodine. Another 3 cases were found to be polyoxyethylene nonylphenyl ether sensitized, and another 1 iodine sensitized, while the patch test reactions of the other 2 were considered to have been elicited by irritation.
authors.affiliation: Department of Dermatology, Yamaguchi Red Cross Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nishioka
authors.forename: T
authors.initials: T
authors.lastname: Seguchi
authors.forename: H
authors.initials: H
authors.lastname: Yasuno
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000485:Allergens / Q000009:adverse effects; D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000145:classification*; D017453:Dermatitis, Irritant / Q000145:classification*; D005260:Female; D005990:Glycerol / Q000009:adverse effects; D006801:Humans; D007455:Iodine / Q000009:adverse effects; D007466:Iodophors / Q000009:adverse effects*; D007509:Irritants / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010592:Pharmaceutic Aids / Q000009:adverse effects; D011092:Polyethylene Glycols / Q000009:adverse effects; D011205:Povidone / Q000009:adverse effects; D011206:Povidone-Iodine / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects
chemical_list: D000485:Allergens; D000891:Anti-Infective Agents, Local; D007466:Iodophors; D007509:Irritants; D010592:Pharmaceutic Aids; D013501:Surface-Active Agents; C404762:polyoxyethylene(10)nonylphenyl ether; D011092:Polyethylene Glycols; D011206:Povidone-Iodine; D007455:Iodine; D011205:Povidone; D005990:Glycerol