How cholesterol modulates the signal.
By coupling to cholesterol, Hedgehog can be anchored to the cells where it is made, yet to act as a morphogen, it must be able to move away from its source. Novel genes have now been identified that control the release and dispersal of Hedgehog, shedding new light on the part played by cholesterol in these processes.
Ingham
P W
PW
MRC Intercellular Signalling Group, Developmental Genetics Programme, The Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK. p.w.ingham@shefffield.ac.uk.
D000818:Animals; D001667:Binding, Competitive; D002784:Cholesterol / Q000502:physiology*; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D011509:Proteoglycans / Q000378:metabolism; D015398:Signal Transduction; D014921:Wings, Animal / Q000166:cytology
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D011509:Proteoglycans; C077245:hh protein, Drosophila; D002784:Cholesterol