title: [Chronic hepatitis: indicators of disease activity].
abstract: OBJECTIVE
  To assess correlations between activity of chronic hepatitis (CH) by morphological data on the liver and alaninaminotransferase (AlAT) serum levels in patients with viral and alcoholic liver lesions.
  
  
  METHODS
  Serological, biochemical blood tests and histology of hepatic biopsy were made in 47 patients with chronic hepatitis.
  
  
  RESULTS
  The Knodell index characterizing the activity of chronic hepatitis by morphological evidence correlated with AlAT activity in the serum. Normal values may be associated with 1 to 5 scores by the Knodell index. AsAT/AlAT was higher in patients with CH free of virus markers.
  
  
  CONCLUSIONS
  Morphological data (Knodell's index), AlAT activity and AsAT/AlAT indicate CH activity. AsAT/AlAT may help in elucidation of the presence or absence of alcohol abuse.
authors.forename: Ts G
authors.initials: TsG
authors.lastname: Masevich
authors.forename: L G
authors.initials: LG
authors.lastname: Ermolaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006508:Hepatitis Antibodies / Q000032:analysis*; D006518:Hepatitis Viruses / Q000276:immunology; D006519:Hepatitis, Alcoholic / Q000175:diagnosis* / Q000201:enzymology; D006521:Hepatitis, Chronic / Q000175:diagnosis* / Q000201:enzymology / Q000821:virology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D006508:Hepatitis Antibodies; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase