title: Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan.
abstract: Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quercetin 3-O-beta-(6"-feruloyl)-galactopyranoside, were isolated as the inhibitors of superoxide production by activity-guided fractionation. IC50 values were shown at the concentrations of 2.1 microM by quercetin 3-O-beta-(2"-galloyl)-glucopyranoside, 1.9 microM by quercetin 3-O-beta-(2"-galloyl)-rhamnoypranoside, and 3.5 microM by quercetin 3-O-beta-(6"-feruloyl)-galactopyranoside whose inhibitory potencies were similar to oxyphenylbutazone (IC50 = 1.9 microM) as a positive control.
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: D S
authors.initials: DS
authors.lastname: Jang
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: J
authors.initials: J
authors.lastname: Yun
authors.forename: B K
authors.initials: BK
authors.lastname: Min
authors.forename: K R
authors.initials: KR
authors.lastname: Min
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
mesh_terms: D000328:Adult; D004952:Esters; D006801:Humans; D008163:Luminescent Measurements; D008213:Lymphocyte Activation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D019664:Polygonaceae / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013481:Superoxides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015054:Zymosan / Q000494:pharmacology*
chemical_list: D004952:Esters; D013481:Superoxides; D015054:Zymosan; D011794:Quercetin