The serological response to papillomaviruses.
The antibody response to papillomaviruses is a key determinant of protective immunity. HPV serology is also an important epidemiological tool for the assay of past and present HPV infections and for prediction of HPV-associated cancers and their precursor lesions. This review focuses on the assay of antibody responses to the HPV capsid, its use as a marker of cumulative HPV exposure and surveys how HPV seroepidemiology has been used to elucidate the spread of HPV infection in various populations, the natural history of HPV infection and that exposure to HPV is associated with increased risk for several human cancers.
Dillner
J
J
Laboratory of Tumour Virus Epidemiology, The Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, S-17177, Sweden.
D000914:Antibodies, Viral / Q000096:biosynthesis; D002213:Capsid / Q000276:immunology; D005260:Female; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000096:biosynthesis; D027383:Papillomaviridae / Q000276:immunology*; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000209:etiology
D000914:Antibodies, Viral; D007132:Immunoglobulin Isotypes