Aromatase and sulfatase inhibitors from Lepiota americana.
From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC50 = 5.7 microM and 3 beta-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC50 = 0.9 microM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3 beta-hydroxy-5,8-epidioxyergosta-6,22-diene active against aromatase.
Kim
D S
DS
Jeong
H J
HJ
Bhat
K P
KP
Park
S Y
SY
Kang
S H
SH
Yoo
E H
EH
Lee
M
M
Lee
H W
HW
Krueger
R J
RJ
Kim
D S
DS
D000363:Agaricales / Q000737:chemistry*; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013429:Sulfatases / Q000037:antagonists & inhibitors*
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D010078:Oxazines; C005512:3-aminophenoxazone; D013429:Sulfatases; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol