title: Keratomycosis: clinical and microbiologic experience with dematiaceous fungi.
abstract: OBJECTIVE
  To assess the significance of dematiaceous fungi in the causation of keratomycosis.
  
  
  METHODS
  Retrospective, noncomparative case series.
  
  
  METHODS
  Eighty-eight cases of dematiaceous fungal keratitis seen at the L. V. Prasad Eye Institute, Hyderabad, India from January 1991 through December 1996.
  
  
  METHODS
  Only culture-proven cases were analyzed.
  
  
  METHODS
  Predisposing factors, clinical characteristics, microbiology, treatment methods, and outcome.
  
  
  RESULTS
  Of 557 cases of fungal keratitis seen during the study period, dematiaceous fungi were the etiologic agents in 88 (15.7%), after Fusarium in 210 (37.6%) and Aspergillus species in 170 cases (30.4%), respectively. Trauma was the most common predisposing factor (47.7%). Fifty-three eyes (61.3%) had the classical clinical picture of yellow-white, dry raised infiltrate with feathery hyphate edges at initial examination. The characteristic macroscopic pigmentation was seen in only 24 eyes (27.27%). Septate branching fungal filaments were identified in 78 smears (88.63%) on light microscopy, of which 5 (5.7%) also showed the presence of bacteria. Curvularia species dominated the spectrum (22.7%). Treatment was started in 48 eyes with topical antifungal agents, whereas 37 received both oral and topical antifungal agents. Outcome data were available for 68 cases. Forty-nine (72%) responded to medical therapy, whereas 13 eyes required therapeutic penetrating keratoplasty and 6 eyes had to be eviscerated.
  
  
  CONCLUSIONS
  This is the largest series of keratitis caused by dematiaceous fungi reported to date. It clearly brings out the clinical importance of this group of corneal infections.
authors.affiliation: Sight Savers' Corneal Training Centre, L.V. Prasad Eye Institute, Banjara Hills, Hyderabad, India. prashant@lvpeye.stph.net
authors.forename: P
authors.initials: P
authors.lastname: Garg
authors.forename: U
authors.initials: U
authors.lastname: Gopinathan
authors.forename: K
authors.initials: K
authors.lastname: Choudhary
authors.forename: G N
authors.initials: GN
authors.lastname: Rao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003315:Cornea / Q000382:microbiology* / Q000473:pathology; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007634:Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D003904:Mitosporic Fungi / Q000302:isolation & purification*; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D012189:Retrospective Studies
chemical_list: D000935:Antifungal Agents