title: [Merkel cell tumor of the eyelids: review of the literature and report of 2 patients].
abstract: BACKGROUND
  The Markel cell carcinoma is a rare malignant skin tumor. The tumor was first described in 1972 by Toker and he named it trabecular carcinoma. We had the opportunity to treat two patients with a Merkel cell carcinoma of the upper and lower eyelid and reviewed the literature using the "Medline" database concerning Merkel cell carcinomas of the ocular adnexa.
  
  
  METHODS
  A 76-year-old female patient was referred to our hospital because of an inflammatory tumor of the left upper eyelid present for two months. A 91-year-old male patient noticed for four weeks a painless itching lesion at the left lower eyelid. The remaining ophthalmologic examination in these patients was unremarkable.
  
  
  RESULTS
  Both tumors were excised. Histological and immunohistochemical examination verified a Merkel cell carcinoma in both cases. The 76-year-old female patient exhibited no recurrent tumor after a follow-up of 18 months. The 91-year-old male patient had a recurrent tumor inferior to the temporal lower eyelid 7 months after tumor excision, however, lymph node metastasis is not present as of yet. The patient underwent radiation therapy with cobalt of the left orbit with a total dose of 60 Gy.
  
  
  CONCLUSIONS
  Merkel cell carcinomas can occur everywhere on the skin; the eyelids are affected in 10% of all cases. Best histochemical markers are cytokeratin 20 and neurospecific enolase. A review of the literature revealed 31 patients with Merkel cell carcinomas involving the eyelids. Female patients were more often affected than male patients. The upper eyelid was more frequently involved than the lower eyelid. Recurrent disease is frequent.
authors.affiliation: Universitäts-Augenklinik ULM. harald.gaeckle@medizin.uni-ulm.de
authors.forename: H C
authors.initials: HC
authors.lastname: Gäckle
authors.forename: C W
authors.initials: CW
authors.lastname: Spraul
authors.forename: P
authors.initials: P
authors.lastname: Wagner
authors.forename: P
authors.initials: P
authors.lastname: Möller
authors.forename: G K
authors.initials: GK
authors.lastname: Lang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015266:Carcinoma, Merkel Cell / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005142:Eyelid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005143:Eyelids / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery