Comparison of the effect of lipid A analog E5531 and the lipid A from Escherichia coli on phospholipid membrane properties.
The effect of the lipid A analog E5531 on the phospholipid membrane was compared with that of the lipid A from Escherichia coli (EC). E5531 decreased the phase transition temperature of dipalmitoylphosphatidylcholine (DPPC) membrane and increased the fluidity and micropolarity. On the other hand, the effect of EC on the membrane was contradictory. These results suggested that the reason for the difference of biological effects of these two lipid A would be caused by the differences from the effect on the cell membranes.
Asai
Y
Y
Formulation Research Laboratory, Kawashima, Eisai Company, Limited, Gifu, Japan.
Watanabe
S
S
D002462:Cell Membrane / Q000502:physiology; D004926:Escherichia coli / Q000737:chemistry*; D008050:Lipid A / Q000031:analogs & derivatives* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000378:metabolism; D008081:Liposomes; D008560:Membrane Fluidity / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism*
D008050:Lipid A; D008070:Lipopolysaccharides; D008081:Liposomes; D010743:Phospholipids; C092845:E 5531