Improved compression properties of propyphenazone spherical crystals.
Spherical propyphenazone crystals were produced by an agglomeration technique using a three solvents system. After selecting the best propyphenazone solvent (ethyl alcohol), non-solvent (demineralized water) and bridging liquid (isopropyl acetate), several of their ratios were tested by a Sheffé ternary diagram. Micromeritic properties of agglomerates such as flowability, were improved and their compression behavior was investigated and compared to that of raw crystals. By compression and densification studies, along with tablet SEM analysis, we have been able to explain the compression mechanism of propyphenazone spherical crystals and have shown that their better tablet/ability can be due to the small size of individual particles in the agglomerates
Di Martino
P
P
Laboratorio di Tecnica Farmaceutica, Facoltà di Farmacia, Dipartimento di Scienze Chimiche, Via S. Agostino, 62032, Camerino, Italy. dimartin@camserv.unicam.it
Di Cristofaro
R
R
Barthélémy
C
C
Joiris
E
E
Palmieri Filippo
G
G
Sante
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D004339:Drug Compounding; D004548:Elasticity; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011208:Powders; D011312:Pressure; D012995:Solubility; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011208:Powders; D012997:Solvents; D013607:Tablets; C009077:propyphenazone; D000983:Antipyrine