Hepatoprotective effects of Liv-52 on ethanol induced liver damage in rats.
The mechanism of protective effects of Liv-52, a multiherbal hepatoprotective drug, on ethanol induced hepatic damage has been investigated. The results indicate that Liv-52 treatment prevents ethanol induced increase in the activity of the enzyme gamma-glutamyl transpeptidase. Concomitantly there was also a decrease in ethanol accentuated lipid peroxidation in liver following Liv-52 treatment. The activity of antioxidant enzymes; superoxide dismutase, glutathione peroxidase and the levels of glutathione were decreased following ethanol ingestion. Liv-52 treatment was found to have protective effects on the activity of superoxide dismutase and the levels of glutathione. The results obtained from the study indicate hepatoprotective nature of Liv-52 which might be attributed to its ability to inhibit lipid peroxidation.
Sandhir
R
R
Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh, India. medinst@pgi.chid.nic.in
Gill
K D
KD
D000818:Animals; D004338:Drug Combinations; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D004338:Drug Combinations; D010936:Plant Extracts; D000431:Ethanol; C002614:Liv 52