Expression of hnRNP A2/B1 proteins in human cancer cell lines.
The overexpression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is recently reported informative as a marker of lung cancer for early detection. To examine whether the expression of the proteins is specific for lung cancer, immunological analyses were performed both in lung and non-lung cancer cell lines. In immunostaining and Western blotting, the expression of A2/B1 was observed not only in the lung cancer cells but also in non-lung cancer cells. The expression of hnRNP A2/B1 is not specific for lung cancer and quantitative determination of A2/B1 is required to elucidate their significance in carcinogenesis.
Satoh
H
H
Division of Respiratory Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-city, Ibaraki 305-8575, Japan.
Kamma
H
H
Ishikawa
H
H
Horiguchi
H
H
Fujiwara
M
M
Yamashita
Y T
YT
Ohtsuka
M
M
Sekizawa
K
K
D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D015151:Immunoblotting; D008175:Lung Neoplasms / Q000737:chemistry; D008856:Microscopy, Fluorescence; D009369:Neoplasms / Q000737:chemistry*; D012261:Ribonucleoproteins / Q000032:analysis*; D014407:Tumor Cells, Cultured
D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D012261:Ribonucleoproteins; C439768:hnRNP A2