title: HLA-DRB and -DQB1 polymorphism in the Macedonian population.
abstract: HLA-DRB1, DRB3/4/5 and DQB1 polymorphism has been studied in a population of 80 unrelated healthy Macedonians using molecular methods. Twenty-five different DRB1 alleles were identified of which DRB1*1104, *1501, *1601, and *1101 were found most frequently. Among the 15 identified DQB1 alleles, two were predominant: DQB1*0301 and *0502. The most frequent three-locus haplotypes were DRB1*1104-DRB3*02-DQB1*0301 (18%/), DRB1*1101-DRB3*02-DQB1*0301 (9%) and DRB1*1601-DRB5*02-DQB1*0502 (10%). Polymorphism for DRB1*04, *13 and *15 haplotypes was extensive. Eleven different DR2-related haplotypes were found, some of which were unusual for European populations: DRB1*1501-DRB5*0102-DQB1*0502, DRB1*1501-DRB5*02-DQB1*0502, DRB1*1501-DRB5*0102-DQB1*0601.
authors.affiliation: Institute of Blood Transfusion, Skopje, Republic of Macedonia.
authors.forename: A
authors.initials: A
authors.lastname: Hristova-Dimceva
authors.forename: W
authors.initials: W
authors.lastname: Verduijn
authors.forename: R F
authors.initials: RF
authors.lastname: Schipper
authors.forename: G M
authors.initials: GM
authors.lastname: Schreuder
mesh_terms: D000483:Alleles; D004247:DNA / Q000032:analysis; D005260:Female; D005787:Gene Frequency; D005802:Genes, MHC Class II; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018843:Republic of North Macedonia / Q000208:ethnology
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D004247:DNA