Activity revealed in MRI of multiple sclerosis without contrast agent. A preliminary report.
Disease activity in multiple sclerosis is usually accompanied by blood-brain barrier disruption, which can be assessed with contrast-enhanced magnetic resonance imaging (MRI). This paper describes a technique that gives information about disease activity using magnetization transfer MRI. Image combination methods using follow-up scans, like the one presented here, have the potential to show MS lesions that correlate with enhancement.
Horsfield
M A
MA
Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, UK.
Rocca
M A
MA
Cercignani
M
M
Filippi
M
M
D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000473:pathology*; D003287:Contrast Media; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D003287:Contrast Media; D019786:Gadolinium DTPA