Antinociceptive effects of calcitonin gene-related peptide injected into periaqueductal grey of rats with mononeuropathy.
Intra-periaqueductal grey (PAG) injection of calcitonin gene-related peptide (CGRP) induced dose-dependent increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with mononeuropathy. CGRP-induced increases in HWLs were blocked by intra-PAG injection of the CGRP antagonist CGRP8-37. The results demonstrated that CGRP and CGRP receptors in PAG play an important role in antinociception in rats with mononeuropathy.
Xu
S
S
Department of Physiology, College of Life Sciences, Peking University, Beijing, China.
Lundeberg
T
T
Yu
L
L
D000698:Analgesia; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism* / Q000494:pharmacology*; D008297:Male; D020422:Mononeuropathies / Q000188:drug therapy* / Q000503:physiopathology*; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D010147:Pain Measurement; D010487:Periaqueductal Gray / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D015740:Calcitonin Gene-Related Peptide