Higher incidence of elevated body temperature or increased C-reactive protein level in asthmatic children showing transient reduction of theophylline metabolism.
The authors investigated whether theophylline metabolism is decreased in asthmatic patients and what condition may be related to its reduction. Fifty-two children with asthma were given 15 mg/kg/day aminophylline intravenously at a constant rate. Blood and spot urine samples were collected at 24 hours, 48 hours, and 72 hours after beginning infusion. The ratio of plasma theophylline concentration at 72 hours to that at 24 hours (C72h/C24h) varied from 0.42 to 1.51 (average 0.894). Plasma theophylline concentration of patients with lower C72h/C24h than average reduced significantly, while the concentration of those with higher C72h/C24h remained unchanged. The urinary ratio of the sum of the metabolites to theophylline was significantly increased in the patients with the lower ratio. Among the demographic characteristics examined, significant difference was found only in the incidence of patients with C-reactive protein (CRP) of 0.5 mg/dl or greater or patients with a fever of 37.5 degrees C or greater when admitted. Acute febrile illness accompanied by increased CRP level may affect theophylline metabolism.
Yamaguchi
A
A
Department of Pediatrics, St. Marianna University School of Medicine, Kanagawa, Japan.
Tateishi
T
T
Okano
Y
Y
Matuda
T
T
Akimoto
Y
Y
Miyoshi
T
T
Kobayashi
S
S
Koitabashi
Y
Y
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D001993:Bronchodilator Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D002097:C-Reactive Protein / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D013806:Theophylline / Q000009:adverse effects / Q000097:blood / Q000378:metabolism* / Q000652:urine
D001993:Bronchodilator Agents; D002097:C-Reactive Protein; D013806:Theophylline