title: A fine balance between oxidised and reduced haem controls the survival of intraerythrocytic plasmodia.
abstract: The polymerisation of haemoglobin-derived ferri-protoporphyrin IX (Fe(III)PPIX) to haemozoin (malaria pigment) is a crucial process for intraerythrocytic plasmodia to prevent haem toxicity. It is also the target of in-use antimalarial drugs and newer compounds. This reaction and the inhibition thereof can be reproduced and studied in vitro.
authors.affiliation: Istituto di Microbiologia, Università di Milano, Italy. donatella.taramelli@unimi.it
authors.forename: D
authors.initials: D
authors.lastname: Taramelli
authors.forename: D
authors.initials: D
authors.lastname: Monti
authors.forename: N
authors.initials: N
authors.lastname: Basilico
authors.forename: S
authors.initials: S
authors.lastname: Parapini
authors.forename: F
authors.initials: F
authors.lastname: Omodeo-Salé
authors.forename: P
authors.initials: P
authors.lastname: Olliaro
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002478:Cells, Cultured; D004563:Electrochemistry; D004912:Erythrocytes / Q000469:parasitology*; D006418:Heme / Q000378:metabolism*; D006420:Hemeproteins / Q000378:metabolism*; D006427:Hemin / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D010961:Plasmodium / Q000378:metabolism*
chemical_list: D000962:Antimalarials; D006420:Hemeproteins; C020753:hemozoin; D006418:Heme; D006427:Hemin