title: Interaction with human immunodeficiency virus (HIV) type 2 predicts HIV type 1 genotype.
abstract: In West Africa, India, and certain regions of Europe, both human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) are known to cocirculate. To investigate the HIV-1 subtypes involved in dual HIV-1 and HIV-2 infections, we sequenced the envelope C2-V3 region from 29 dually infected female commercial sex workers from Senegal. The majority of women (23 of 29) were infected by HIV-1 subtype A. Within the HIV-1 subtype A sequences, 14 of 23 (60.8%) clustered with the West African associated A/G recombinant form (IbNG), and 9 of 23 (39.2%) formed a separate cluster distinct from the A/G IbNG. In contrast, in HIV-1 singly infected individuals, non-IbNG subtype A was found in only 13 of 98 (13.3%). Therefore, the lack of protection and/or interaction with HIV-2 was associated with a distinct HIV-1 A genotype. These results suggest differences in the biological properties of HIV-1 genotypes and their in vivo interaction with HIV-2.
authors.affiliation: Department of Immunology, Harvard AIDS Institute, Harvard School of Public Health, 651 Huntington Avenue, Boston, Massachusetts, 02115, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Sarr
authors.forename: J L
authors.initials: JL
authors.lastname: Sankalé
authors.forename: D J
authors.initials: DJ
authors.lastname: Hamel
authors.forename: K U
authors.initials: KU
authors.lastname: Travers
authors.forename: A
authors.initials: A
authors.lastname: Guèye-Ndiaye
authors.forename: M
authors.initials: M
authors.lastname: Essex
authors.forename: S
authors.initials: S
authors.lastname: Mboup
authors.forename: P J
authors.initials: PJ
authors.lastname: Kanki
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics; D000595:Amino Acid Sequence; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000502:physiology; D015498:HIV-2 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012675:Senegal / Q000453:epidemiology; D016415:Sequence Alignment