title: Biological problems with the replacement of a vector population by Plasmodium-refractory mosquitoes.
abstract: Attempts are being made to backcross into Anopheles gambiae s.s. the gene(s) which cause zoophily in Anopheles quadriannulatus. Such a backcrossed strain might be preferable to a Plasmodium-refractory strain as a basis for genetic control because a refractory strain could select for evasion of refractoriness in the wild Plasmodium population. The species composition of the malaria vector population in several Tanzanian villages was overwhelmingly An. gambiae s.s. in a normal rainy season, but consisted of four species, all proved by ELISA and/or PCR to carry P. falciparum sporozoites, at the time of the heavy rains associated with El Niño. Thus any scheme, for malaria transmission control by replacement of vectors by genetically-manipulated non-vectors, would have to be able to replace more than one species.
authors.affiliation: London School of Hygiene and Tropical Medicine, UK. chris.curtis@lshtm.ac.uk
authors.forename: C F
authors.initials: CF
authors.lastname: Curtis
authors.forename: H V
authors.initials: HV
authors.lastname: Pates
authors.forename: W
authors.initials: W
authors.lastname: Takken
authors.forename: C A
authors.initials: CA
authors.lastname: Maxwell
authors.forename: J
authors.initials: J
authors.lastname: Myamba
authors.forename: A
authors.initials: A
authors.lastname: Priestman
authors.forename: O
authors.initials: O
authors.lastname: Akinpelu
authors.forename: A M
authors.initials: AM
authors.lastname: Yayo
authors.forename: J T
authors.initials: JT
authors.lastname: Hu
mesh_terms: D000818:Animals; D000852:Anopheles / Q000235:genetics / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D007303:Insect Vectors; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology*; D016133:Polymerase Chain Reaction / Q000662:veterinary