title: Growth hormone treatment of patients with Prader-Willi syndrome. Swedish Growth Hormone Advisory Group.
abstract: Several studies have now been published on the effect of one or several years of growth hormone treatment on growth and body composition of children with Prader-Willi syndrome. The majority of the patients have responded with greatly increased growth rate, decreased body fat and increased muscle volume. Many of these children seem to have a functional growth hormone deficiency, probably secondary to their hypothalamic dysfunction. Further studies are needed to establish the long-term effect of this treatment on somatic and psychological well-being.
authors.affiliation: Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden.
authors.forename: E M
authors.initials: EM
authors.lastname: Ritzén
authors.forename: A C
authors.initials: AC
authors.lastname: Lindgren
authors.forename: L
authors.initials: L
authors.lastname: Hagenäs
authors.forename: C
authors.initials: C
authors.lastname: Marcus
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: S
authors.initials: S
authors.lastname: Blichfeldt
mesh_terms: D001823:Body Composition / Q000187:drug effects; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002648:Child; D020249:Hormone Replacement Therapy / Q000009:adverse effects / Q000523:psychology; D019382:Human Growth Hormone / Q000009:adverse effects / Q000172:deficiency / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006935:Hypercapnia / Q000150:complications / Q000188:drug therapy; D007040:Hypoventilation / Q000150:complications / Q000188:drug therapy; D011218:Prader-Willi Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology
chemical_list: D019382:Human Growth Hormone