title: Incidence of atrial fibrillation after mild or moderate hypothermic cardiopulmonary bypass.
abstract: OBJECTIVE
  Atrial fibrillation remains a significant source of morbidity after coronary artery bypass grafting (CABG). Whether cardiopulmonary bypass (CPB) temperature influences the occurrence of postoperative atrial fibrillation in CABG patients has not been specifically examined. In the present study, we reviewed postoperative data from patients who were prospectively randomized to mild or moderate hypothermic CPB for elective CABG to determine the incidence of postoperative atrial fibrillation.
  
  
  METHODS
  Randomized, single center, observational study.
  
  
  METHODS
  Tertiary university medical center.
  
  
  METHODS
  Adults undergoing elective CABG surgery.
  
  
  METHODS
  Enrolled patients were prospectively randomized to mild (34 degrees C [93.2 degrees F]) or moderate (28 degrees C [82.4 degrees F]) hypothermic CPB.
  
  
  RESULTS
  The incidence of postoperative atrial fibrillation was determined by review of ICU and hospital records. There was a significantly higher incidence of atrial fibrillation in the moderate compared with the mild hypothermic CPB group. Patients who had postoperative atrial fibrillation were significantly older than those without atrial fibrillation. Furthermore, a significant increase in the relative risk of developing postoperative atrial fibrillation was found for both age and CPB temperature.
  
  
  CONCLUSIONS
  Our results indicate that the temperature of systemic cooling during CPB is an important factor in the development of atrial fibrillation after CABG surgery. In addition, this study confirms that increasing age is a significant determinant of postoperative atrial fibrillation.
authors.affiliation: Department of Anesthesiology, Columbia-Presbyterian Medical Center, Columbia University New York, NY, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Adams
authors.forename: E J
authors.initials: EJ
authors.lastname: Heyer
authors.forename: A E
authors.initials: AE
authors.lastname: Simon
authors.forename: E
authors.initials: E
authors.lastname: Delphin
authors.forename: E A
authors.initials: EA
authors.lastname: Rose
authors.forename: M C
authors.initials: MC
authors.lastname: Oz
authors.forename: D J
authors.initials: DJ
authors.lastname: McMahon
authors.forename: L S
authors.initials: LS
authors.lastname: Sun
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000209:etiology*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects* / Q000379:methods*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011446:Prospective Studies; D012307:Risk Factors; D013696:Temperature