The time of day that etidronate is ingested does not influence its therapeutic effect in osteoporosis.
To investigate whether the therapeutic effect of etidronate is affected by the time of ingestion we have retrospectively studied 110 osteoporotic patients. They had been taking etidronate according to the manufacturer's instructions for a mean duration of 2.6 years either on waking (n=47), on retiring (n=47), or during the day (n= 16). No significant differences were found between the three groups with respect to percentage change in bone mineral density at all sites either for the first year of treatment or for the mean yearly percent change throughout the total course of treatment. These findings suggest that the time of ingestion of etidronate does not influence the therapeutic effect if a two hour fast before and after ingestion is adhered to.
Cook
G J
GJ
Division of Radiological Sciences and Medical Engineering Guys, Kings College and St. Thomas' School of Medicine, London, UK.
Blake
G M
GM
Fogelman
I
I
D000284:Administration, Oral; D000368:Aged; D015519:Bone Density; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D004435:Eating; D012968:Etidronic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy* / Q000473:pathology; D019518:Postprandial Period; D012189:Retrospective Studies
D012968:Etidronic Acid