Improved estimation of dermal pesticide dose to agricultural workers upon reentry.
Agricultural workers reentering fields after pesticide application to engage in hand labor activities are subject to potentially significant dermal exposures to residues on foliage and in soil. Environmental Protection Agency (EPA) guidelines for assessment of post-application exposures were originally described in the 1984 Pesticide Assessment Guidelines Subdivision K which is currently undergoing revision. A successor document will eventually appear as Series 875, Group B Postapplication Exposure Monitoring Test Guidelines. Regulatory protocols found in these documents utilize dislodgeable foliar residues, foliage-to-human-transfer coefficients, and duration of activity to estimate exposure. Dermal absorption factors are then used to estimate dose. However, the experiments from which absorption factors are derived typically involve constant or nearly constant exposures which are not consistent with assumed field exposure conditions. This can lead to inconsistent interpretation and questionable dose estimates. An AFL-CIO challenge to procedures used by EPA to estimate the dose of the fungicide captan [N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide] to strawberry harvesters, which elicited a response from EPA, provides a useful opportunity for examination of the derivation and use of absorption factors. An improved, but still relatively simple, method for dermal dose estimation featuring explicit treatment of the time dependence of absorption has been developed. A benefit of the proposed method is capability for consideration of the effect of delay in post-shift washing on dose.
Kissel
J
J
Department of Environmental Health, University of Washington, Seattle, USA.
Fenske
R
R
D000383:Agriculture; D000818:Animals; D002215:Captan / Q000009:adverse effects* / Q000493:pharmacokinetics; D004784:Environmental Monitoring; D005659:Fungicides, Industrial / Q000009:adverse effects* / Q000493:pharmacokinetics; D006801:Humans; D016273:Occupational Exposure / Q000517:prevention & control*; D010575:Pesticides / Q000009:adverse effects* / Q000493:pharmacokinetics; D051381:Rats; D012869:Skin Absorption
D005659:Fungicides, Industrial; D010575:Pesticides; D002215:Captan