Model systems to evaluate the use of transgenic haematophagous insects to deliver protective vaccines.
Insect vector control has proved an effective method for reducing the transmission of disease-causing organisms to human populations in many tropical countries. We are interested in employing direct genetic manipulation of insect vector genomes to use them in beneficial ways so as to have a profound and long-lasting effect on disease transmission. Our research focuses on assessing whether haematophagous insects may be used as a means to deliver protective proteins, such as an antimalarial vaccine, when they take a blood meal. The progress which has been made towards assessing this concept using a number of model systems is described.
Crampton
J M
JM
Liverpool School of Tropical Medicine, UK. jmc@liverpool.ac.uk
Stowell
S L
SL
Karras
M
M
Sinden
R E
RE
D000330:Aedes / Q000235:genetics*; D000818:Animals; D000953:Antigens, Protozoan / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D004331:Drosophila melanogaster; D017780:Malaria Vaccines / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D009032:Mosquito Control; D015800:Protozoan Proteins / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology; D011994:Recombinant Proteins / Q000096:biosynthesis; D019076:Transgenes
D000953:Antigens, Protozoan; D017780:Malaria Vaccines; D015800:Protozoan Proteins; D011994:Recombinant Proteins; C084246:ookinete surface antigen Pbs21, Plasmodium