Consolidation behavior of an experimental, cross-linked polyalkyl ammonium polymer.
The effect of various factors (i.e., particle size, lubricant, moisture, and excipients) on the tableting properties of DMP 504 powder, an experimental, cross-linked polyalkyl ammonium polymer, was studied using an instrumented single-punch tablet press. The results indicate that plastic deformation is the primary consolidation mechanism for DMP 504. Lubrication of DMP 504 with magnesium stearate resulted in negative interaction in compactibility. The increase in tablet hardness with increase in water content of DMP 504 (up to 2.5%) could be attributed to the lubricating effect of water. Increasing the water content above the optimum moisture range (i.e., 2.5% to 4.0%) caused a drastic reduction in tablet crushing strength due to the hydrodynamic resistance. A mixture of DMP 504 with microcrystalline cellulose or starch led to a positive interaction with respect to compactibility. A deviation in tablet strength from the linear interpolated value did not correspond to a deviation in tablet thickness. The improved compactibility for the mixture of DMP 504 and microcrystalline cellulose or starch is not related directly to the facilitated densification.
Chang
R K
RK
DuPont Pharmaceutical Company, Experimental Station, Wilmington, DE 19880, USA.
Hussain
M A
MA
D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D008153:Lubrication; D010316:Particle Size; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D013607:Tablets / Q000737:chemistry
C111415:DMP-504; D011108:Polymers; D000644:Quaternary Ammonium Compounds; D013607:Tablets