Interferon-gamma-dependent/independent expression of indoleamine 2,3-dioxygenase. Studies with interferon-gamma-knockout mice.
The role of IFN-gamma in the expression of indoleamine 2,3-dioxygenase (IDO), a tryptophan oxidizing enzyme, in mouse tissues under physiological and pathological conditions was investigated using IFN-gamma-knockout mice. The results revealed that i) the expression of IDO in the large intestine or in the cecum is mediated by IFN-gamma, ii) for the systemic IDO induction under endotoxin shock, IFN-gamma is a dominant inducer but not essential, and an IFN-gamma-independent mechanism is also operative, iii) the systemic induction of IDO caused by IL-12 or Pokeweed mitogen is mediated by IFN-gamma, and iv) the constitutive IDO expression in the epididymis is IFN-gamma-independent.
Takikawa
O
O
Osaka Bioscience Institute, Japan. takikawa@uow.edu.au
Tagawa
Y
Y
Iwakura
Y
Y
Yoshida
R
R
Truscott
R J
RJ
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects / Q000276:immunology; D004822:Epididymis / Q000201:enzymology; D015971:Gene Expression Regulation, Enzymologic / Q000276:immunology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018664:Interleukin-12 / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011070:Poly I-C / Q000494:pharmacology; D012772:Shock, Septic / Q000201:enzymology; D014366:Tryptophan Oxygenase / Q000096:biosynthesis / Q000235:genetics*
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D018664:Interleukin-12; D007371:Interferon-gamma; D014366:Tryptophan Oxygenase; D011070:Poly I-C