title: Irritant thresholds in subjects with colophony allergy.
abstract: The factors which determine individual susceptibility to the development of allergic contact dermatitis (ACD) are not well defined. Since it is known that the presence of skin irritation is well-documented as a promoter of sensitization, the sensitivity to irritation of subjects with ACD has been compared with a normal control group. Whilst 78% of those with a positive patch test reaction to the contact allergen colophony (colophonium) responded to a concentration of no higher than 2.5% sodium lauryl sulfate (SLS), only 44% of the matched control group reacted at this level of SLS. Thus, the results are consistent with the hypothesis that individuals with enhanced susceptibility to skin irritation are also more liable to develop allergic skin reactivity.
authors.affiliation: St John's Institute of Dermatology, St Thomas's Hospital, London, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Holloway
authors.forename: D K
authors.initials: DK
authors.lastname: Armstrong
authors.forename: D A
authors.initials: DA
authors.lastname: Basketter
authors.forename: J P
authors.initials: JP
authors.lastname: McFadden
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000009:adverse effects*; D016022:Case-Control Studies; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000503:physiopathology; D004198:Disease Susceptibility; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007114:Immunization; D007509:Irritants / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012116:Resins, Plant / Q000009:adverse effects*; D012867:Skin / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000009:adverse effects*; D013638:Tars / Q000009:adverse effects*
chemical_list: D000485:Allergens; D007509:Irritants; D012116:Resins, Plant; D013501:Surface-Active Agents; D013638:Tars; D012967:Sodium Dodecyl Sulfate; C013893:rosin