Effect of honey on multidrug resistant organisms and its synergistic action with three common antibiotics.
A total of 15 bacterial strains (7 Pseudomonas & 8 Klebsiella species) isolated from various samples which showed multi-drug resistance were studied to verify in vitro antibacterial action of honey on the principle of Minimum Inhibitory Concentration (MIC) & its synergism with 3 common antibiotics--Gentamicin, Amikacin & Ceftazidime. The MIC of honey with saline for both organisms was found to be 1:2. The synergistic action was seen in the case of Pseudomonas spp. and not with Klebsiella spp.
Karayil
S
S
Department of Microbiology, T.N.M.C. & B.Y.L. Nair Charitable Hospital, Mumbai.
Deshpande
S D
SD
Koppikar
G V
GV
D000583:Amikacin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002442:Ceftazidime / Q000627:therapeutic use; D018432:Drug Resistance, Multiple; D004357:Drug Synergism; D005839:Gentamicins / Q000627:therapeutic use; D006722:Honey; D007709:Klebsiella / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000583:Amikacin; D002442:Ceftazidime