The effect of dopamine on the rapidly adapting receptors in the dog lung.
The effect of an infusion of dopamine (50 microg/kg per min) on both resting and histamine-stimulated discharge of rapidly adapting receptors has been studied in the dog lung. In dogs pretreated with propranolol and phentolamine (1 mg/kg) dopamine inhibited the ability of histamine to stimulate the rapidly adapting receptors. This inhibition was attenuated by sulpiride, a selective D(2)antagonist, (0.5 mg/kg i.v.). Dopamine did not affect the increases in R(L)or the falls in C(dyn)produced by histamine. It is suggested that dopamine may play a role in the control of lung function by reducing the ability of sensory nerves to produce harmful reflex activity.
Jackson
D M
DM
Department of Pharmacology, Astra Charnwood, Loughborough, Leics, LE11 ORH, UK. Dale.Jackson@Charnwood.gb.astra.com
Simpson
W T
WT
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001249:Asthma / Q000517:prevention & control*; D002628:Chemoreceptor Cells / Q000187:drug effects*; D004195:Disease Models, Animal; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D007275:Injections, Intravenous; D008168:Lung / Q000187:drug effects* / Q000294:innervation / Q000502:physiology; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D013469:Sulpiride / Q000494:pharmacology
D000318:Adrenergic beta-Agonists; D018492:Dopamine Antagonists; D013469:Sulpiride; D006632:Histamine; D004298:Dopamine