Translocation (5;9)(q22;q34) in a case of acute lymphoblastic leukemia with multiple bone involvement: effectiveness of donor lymphocyte infusion for relapse after allogeneic stem cell transplantation.
A case of acute lymphoblastic leukemia with a new translocation, t(5;9)(q22;q34) is reported with special reference to the clinical features and the response to treatment. This case exhibited several unique clinical features, including expression of the myeloid antigen on the early pre-B-cell phenotype, multiple bone involvement, and favorable response to donor lymphocyte infusion despite early relapse after allogeneic hematopoietic stem cell transplantation.
Tsujimura
H
H
Division of Hematology-Oncology, Chiba Cancer Center Hospital, Chiba, Japan.
Kumagai
K
K
Yokota
A
A
Narita
M
M
Sakai
C
C
Takagi
T
T
D000328:Adult; D001859:Bone Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy; D002895:Chromosomes, Human, Pair 5; D002899:Chromosomes, Human, Pair 9; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D017710:Lymphocyte Transfusion; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous