[24-hour monitoring of gastric juice pH in assessment of anti-ulcer treatment].
OBJECTIVE
Comparison of various schemes of three-component eradication of duodenal ulcer (DU) using 24-h monitoring of gastric juice pH.


METHODS
62 DU patients in aggravation period have undergone 24-h monitoring of gastric juice pH and esophagogastroduodenoscopy with biopsy and H.pylori test of the treatment beginning and end. Patients of group 1 (n = 28) received ranitidin, metronidazole and amoxicillin while patients of group 2 (n = 34) took quamatel, metronidazole and amoxicillin.


RESULTS
24-h monitoring of pH of the gastric juice demonstrated that three-component therapy consisting of quamatel (20 mg/day, metronidazole (500 mg 4 times a day), amoxicillin (750 mg 3 times a day) maintains the level of intragastric acidity optimal for quick scarring of duodenal ulcer defect and led to eradication of H.pylori in 91.2% of cases.


CONCLUSIONS
24-h monitoring of gastric juice pH is a significant method of assessment of antiulcer treatment efficacy.
Maev
I V
IV
Andreev
N G
NG
Val'tsova
E D
ED
Romashkina
M A
MA
Ismailova
M Z
MZ
D000328:Adult; D000658:Amoxicillin / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001706:Biopsy; D002940:Circadian Rhythm / Q000502:physiology*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D016145:Endoscopy, Digestive System; D015738:Famotidine / Q000627:therapeutic use; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008875:Middle Aged; D011899:Ranitidine / Q000627:therapeutic use; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D008795:Metronidazole; D015738:Famotidine; D000658:Amoxicillin; D011899:Ranitidine