title: LC determination of octreotide acetate in compound formulations of Sandostatin and diamorphine hydrochloride.
abstract: The determination of octreotide acetate in compound formulations of Sandostatin and diamorphine hydrochloride by RP-LC is described. Octreotide acetate, diamorphine hydrochloride and their respective degradants, [des-Thr-ol8]-octreotide and 6-O-acetylmorphine, were baseline resolved using a Lichrospher-60 RP-select B column with a mobile phase composition of acetonitrile/phosphate buffer (pH 7.4, 20 mM) (35:65 v/v) with UV detection at 210 nm. The method is simple, selective, precise and suitable for the determination of octreotide acetate in admixture.
authors.affiliation: Department of Pharmaceutical Sciences, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK.
authors.forename: N
authors.initials: N
authors.lastname: Kyaterekera
authors.forename: J N
authors.initials: JN
authors.lastname: Tettey
authors.forename: G G
authors.initials: GG
authors.lastname: Skellern
authors.forename: D G
authors.initials: DG
authors.lastname: Watson
authors.forename: J
authors.initials: J
authors.lastname: Urie
authors.forename: J R
authors.initials: JR
authors.lastname: McDade
authors.forename: H
authors.initials: H
authors.lastname: Fielding
mesh_terms: D002021:Buffers; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004338:Drug Combinations; D003932:Heroin / Q000032:analysis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D015282:Octreotide / Q000032:analysis* / Q000737:chemistry
chemical_list: D002021:Buffers; D004338:Drug Combinations; D003932:Heroin; D015282:Octreotide