title: [Genetic factors and insulin resistance].
abstract: Diabetes is characterized by impaired insulin secretion from pancreatic beta-cell and/or insulin resistance in peripheral tissues. Genetic factors affecting the insulin sensitivities have been described, including the mutations of genes of insulin receptor, insulin receptor substrate-1, glycogen synthase, uncoupling proteins, beta3-adrenergic receptor, and peroxisome proliferator-activated receptor gamma. Mutant insulin receptors might act as a monogenic factor, but most of the others act as one of the genetic factors of a polygenetic disease.
authors.affiliation: Department of Metabolism and Clinical Nutrition, Kyoto University Graduate School of Medicine.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Seino
mesh_terms: D002352:Carrier Proteins / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics; D006006:Glycogen Synthase / Q000235:genetics; D006801:Humans; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000235:genetics*; D007473:Ion Channels; D008565:Membrane Proteins / Q000235:genetics; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D009154:Mutation; D010750:Phosphoproteins / Q000235:genetics; D011506:Proteins / Q000235:genetics; D011972:Receptor, Insulin / Q000235:genetics; D011943:Receptors, Adrenergic, beta / Q000235:genetics; D022702:Receptors, Adrenergic, beta-3; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2
chemical_list: D002352:Carrier Proteins; C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D010750:Phosphoproteins; D011506:Proteins; D011943:Receptors, Adrenergic, beta; D022702:Receptors, Adrenergic, beta-3; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D006006:Glycogen Synthase; D011972:Receptor, Insulin