Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro.
Microbroth dilution tests in vitro showed the same IC(50) values for itraconazole and hydroxy-itraconazole, within a mode +/- one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10-15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with bioassay marker strains of Candida kefyr and Candida albicans showed no susceptibility variations outside the mode +/- one dilution range. We conclude that few fungi differ substantially in their susceptibility to itraconazole and hydroxy-itraconazole.
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Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK. f.odds@abdn.ac.uk
Bossche
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D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D005658:Fungi / Q000187:drug effects*; D017964:Itraconazole / Q000031:analogs & derivatives* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D014249:Trichophyton / Q000187:drug effects
D000935:Antifungal Agents; C084794:hydroxyitraconazole; D017964:Itraconazole