title: Genomic-scale analysis of gene expression in resting and activated T cells.
abstract: Recent advances in gene array technology and isolation of lymphocytes now allow comprehensive analysis of gene expression in many different types of T cells. So far only a few sets of results have been published. However it is already clear that these analyses provide accurate measurements of gene expression in T cells. This technology offers the first opportunity to examine global and subtle changes in gene expression in response to specific stimuli.
authors.affiliation: Departments of Biochemistry and Molecular Biology, Immunology and Medicine, Howard Hughes Medical Institute, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA. marrackp@njc.org
authors.forename: P
authors.initials: P
authors.lastname: Marrack
authors.forename: T
authors.initials: T
authors.lastname: Mitchell
authors.forename: D
authors.initials: D
authors.lastname: Hildeman
authors.forename: R
authors.initials: R
authors.lastname: Kedl
authors.forename: T K
authors.initials: TK
authors.lastname: Teague
authors.forename: J
authors.initials: J
authors.lastname: Bender
authors.forename: W
authors.initials: W
authors.lastname: Rees
authors.forename: B C
authors.initials: BC
authors.lastname: Schaefer
authors.forename: J
authors.initials: J
authors.lastname: Kappler
mesh_terms: D000818:Animals; D002469:Cell Separation; D016208:Databases, Factual; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D016678:Genome; D006358:Hot Temperature; D006801:Humans; D019169:Jurkat Cells; D008213:Lymphocyte Activation / Q000187:drug effects / Q000235:genetics*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D010703:Phorbol Esters / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
chemical_list: D010703:Phorbol Esters; D012333:RNA, Messenger