Development of new drug delivery system for protein drugs using silicone (I).
A novel technique, by which protein drugs effective in small doses can be released over a long period, was developed using silicone and a water-soluble substance. In this study, interferon (IFN) was used as a model of the protein drugs. The IFN-silicone formulation released IFN over long periods of time in vitro and suppressed tumor growth in nude mice for about 100 days after a single administration. This indicates that physiologically active IFN is released over a prolonged period of time from the IFN-silicone formulation in vivo. Silicone formulations are expected to be a practically feasible sustained-release formulation.
Kajihara
M
M
Research Center, Sumitomo Pharmaceuticals Co. Ltd., 3-45 Kurakakiuchi 1-Chome, Ibaraki-shi, Osaka, Japan. kajihara@sumitomopharm.co.jp
Sugie
T
T
Mizuno
M
M
Tamura
N
N
Sano
A
A
Fujioka
K
K
Kashiwazaki
Y
Y
Yamaoka
T
T
Sugawara
S
S
Urabe
Y
Y
D000818:Animals; D003692:Delayed-Action Preparations; D004129:Dimethylpolysiloxanes; D005260:Female; D005998:Glycine / Q000737:chemistry; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use; D007700:Kinetics; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D009368:Neoplasm Transplantation; D009997:Osmotic Pressure; D010316:Particle Size; D011208:Powders; D012828:Silicones / Q000737:chemistry*; D012995:Solubility; D014407:Tumor Cells, Cultured
D003692:Delayed-Action Preparations; D004129:Dimethylpolysiloxanes; D016898:Interferon-alpha; D011208:Powders; D012828:Silicones; C013830:baysilon; D005998:Glycine