Mesangial nephropathy in Sjögren's syndrome.
We describe a 36-year-old woman with Primary Sjögren's Syndrome (PSS). Purpura, corneal perforation, metabolic acidosis, decreased glomerular filtration, hypokalemia, hyposthenuria, and polyuria were present. Chronic renal insufficiency and renal tubular acidosis type I were diagnosed. Kidney biopsy revealed mesangial glomerulonephritis, interstitial nephritis, and tubular atrophy. Replacement treatment with saliva, tears, and potassium citrate was started. She was given prednisone and cyclophosphamide. This would be the first description of PSS, mesangial glomerulonephritis, and chronic renal insufficiency.
Gamrón
S
S
Rheumatology Unit, Hospital Nacional de Clínicas, School of Medicine, National University of Córdoba, Argentina.
Barberis
G
G
Onetti
C M
CM
Strusberg
I
I
Hliba
E
E
Martellotto
G
G
Jara
H G
HG
Sesin
A M
AM
D000141:Acidosis, Renal Tubular / Q000150:complications / Q000473:pathology; D000328:Adult; D005260:Female; D005920:Glomerular Mesangium / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology; D009395:Nephritis, Interstitial / Q000150:complications* / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000473:pathology