Restoration of impaired T-cell proliferation after parathyroidectomy in hemodialysis patients.
OBJECTIVE
Severe secondary hyperparathyroidism is not infrequent in hemodialysis patients and recent studies suggest that parathyroid hormone (PTH) may play a role in the genesis of cell immunity abnormalities in uremia. The aim of the present study is to describe the effect of parathyroidectomy on T- and B-cell functions in hemodialysis patients.


METHODS
The study was performed on 6 patients with severe secondary hyperparathyroidism. iPTH, B, CD4(+), CD8(+), total number of lymphocytes, lymphoproliferative response to PHA, PWM and Candidin, and IgG, IgM, IL-2 production in vitro were determined 1 day before and 4 months after parathyroidectomy.


RESULTS
The lymphoproliferative response to PHA increased significantly after parathyroidectomy. We also observed a trend to an increase in production of IgG and IgM after PWM stimulation before therapy.


CONCLUSIONS
The present study suggests that patients with extremely high levels of PTH show a complete restoration of impaired T-cell proliferation after parathyroidectomy.
Tzanno-Martins
C
C
Division of Immunology, University of São Paulo Medical School, São Paulo, Brazil. jotape@telnet.com.br
Futata
E
E
Jorgetti
V
V
Duarte
A J
AJ
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D006435:Renal Dialysis; D013601:T-Lymphocytes / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D010281:Parathyroid Hormone; D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens