title: Computationally efficient and statistically robust image reconstruction in three-dimensional diffraction tomography.
abstract: Diffraction tomography (DT) is an inversion scheme used to reconstruct the spatially variant refractive-index distribution of a scattering object. We developed computationally efficient algorithms for image reconstruction in three-dimensional (3D) DT. A unique and important aspect of these algorithms is that they involve only a series of two-dimensional reconstructions and thus greatly reduce the prohibitively large computational load required by conventional 3D reconstruction algorithms. We also investigated the noise characteristics of these algorithms and developed strategies that exploit the statistically complementary information inherent in the measured data to achieve a bias-free reduction of the reconstructed image variance. We performed numerical studies that corroborate our theoretical assertions.
authors.affiliation: Department of Radiology, The University of Chicago, Illinois 60637, USA. anastasi@jedi.bsd.uchicago.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Anastasio
authors.forename: X
authors.initials: X
authors.lastname: Pan
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003198:Computer Simulation; D007091:Image Processing, Computer-Assisted; D008962:Models, Theoretical; D014054:Tomography