title: Experimental Goettingen minipig and beagle dog as two species used in bioequivalence studies for clinical pharmacology (5-aminosalicylic acid and atenolol as model drugs).
abstract: Due to proven similarities in biotransformation between man and minipig, minipig seems to be the experimental animal of choice for preclinical pharmacokinetic studies when an experiment with a drug exhibiting a great first pass bioelimination (like 5-aminosalicylic acid) is to be realised. On the other hand, both minipig and dog may be suitable species for a pharmacokinetic study with a drug characterized by a small extent of first pass biotransformation (like atenolol).
authors.affiliation: Institute of Experimental Biopharmaceutics, Joint Laboratory of Czech Academy of Sciences and PRO.MED.CS, Hradec Králové, Czech Republic. uebf@hk.cesnet.cz
authors.forename: J
authors.initials: J
authors.lastname: Kvetina
authors.forename: Z
authors.initials: Z
authors.lastname: Svoboda
authors.forename: M
authors.initials: M
authors.lastname: Nobilis
authors.forename: J
authors.initials: J
authors.lastname: Pastera
authors.forename: P
authors.initials: P
authors.lastname: Anzenbacher
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001262:Atenolol / Q000097:blood / Q000493:pharmacokinetics*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D006801:Humans; D019804:Mesalamine / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine; D013556:Swine, Miniature; D013810:Therapeutic Equivalency
chemical_list: D019804:Mesalamine; D001262:Atenolol