title: Stability of meperidine in an implantable infusion pump using capillary gas chromatography-mass spectrometry and a deuterated internal standard.
abstract: A capillary gas chromatographic-mass spectrometric (GC MS) method is described for the analysis of meperidine using 3,3,5,5-[2H4]-meperidine as an internal standard. Chromatography was performed on a (5% phenyl) methylpolysiloxane column (30 m x 0.32 mm I.D., 0.25 microm film thickness) operated at 195 degrees C; helium carrier gas-50 cm/s(-1), tR = 2.3 min. Ionization was by electron impact (EI) and detection by selected ion monitoring of the molecular ions. The method provided high response linearity (mean r = 0.9982) and precision (< 6.5% C.V.). Application of this method to a pilot study of aqueous meperidine x HCl (10 mg/ml(-1)) stability in a surgically implantable infusion pump at 37 degrees C for 90 days revealed no demonstrable drug degradation.
authors.affiliation: Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston 29425-2207, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Harvey
authors.forename: C P
authors.initials: CP
authors.lastname: Toussaint
authors.forename: S E
authors.initials: SE
authors.lastname: Coe
authors.forename: E E
authors.initials: EE
authors.lastname: Watson
authors.forename: M G
authors.initials: MG
authors.lastname: O'Neil
authors.forename: K S
authors.initials: KS
authors.lastname: Patrick
mesh_terms: D000701:Analgesics, Opioid / Q000737:chemistry*; D003903:Deuterium; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D015918:Infusion Pumps, Implantable; D008614:Meperidine / Q000737:chemistry*; D010865:Pilot Projects; D012015:Reference Standards; D015203:Reproducibility of Results
chemical_list: D000701:Analgesics, Opioid; D008614:Meperidine; D003903:Deuterium