[From the genetics to the prevention of stroke].
Genetic risk factors implicated in stroke are reviewed. There is evidence that family history of vascular disease is an independent risk factor for stroke. Twin studies demonstrated that there is a genetic component for stroke. I review the possible pathogenetic relevance of several vascular risk factors, namely dyslipoproteinemia, Lp(a), ApoE, homocystein, and prothrombotic states. Finally, I carry out an overview of genetic monogenic disorders manifesting with embolic stroke, thrombotic stroke or hemorrhagic stroke. This review corroborates that there are many genetic risk factors of stroke, though further studies will be necessary to establish whether or not these factors are pathogenetically independent from acquired factors.
Berciano
J
J
Servicio de Neurología, Hospital Universitario Marqués de Valdecilla, Santander, España. neuro@humv.es
D001053:Apolipoproteins / Q000235:genetics; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D015870:Gene Expression / Q000235:genetics; D006801:Humans; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000517:prevention & control*
D001053:Apolipoproteins