The development of and perspectives for genetic engineering of malaria parasites.
The genetic manipulation of malaria parasites is a rapidly emerging technology that offers great promise for the investigation of many aspects of infection. Currently it is possible to transform avian, rodent, primate as well as human parasites, the latter three on a stable, drug selectable basis. This review focuses on the history of the development of the technology, current abilities and future perspectives.
Waters
A P
AP
Department of Parasitology, Leiden University Medical Centre, The Netherlands. a.p.waters@parasitology.medfac.leidenuniv.nl
Janse
C J
CJ
D000818:Animals; D016054:DNA, Protozoan / Q000737:chemistry; D004274:DNA, Recombinant / Q000737:chemistry; D005818:Genetic Engineering; D006801:Humans; D008288:Malaria / Q000469:parasitology*; D010961:Plasmodium / Q000235:genetics*; D014162:Transfection; D019076:Transgenes
D016054:DNA, Protozoan; D004274:DNA, Recombinant