title: Schizophrenia: the fundamental questions.
abstract: Identifying the correct phentotype of schizophrenia is perhaps the most important goal of modern research in schizophrenia. This identification is the necessary antecedent of indentifying the pathophysiology and etiology. A working model is proposed, which suggests that the phenotype should be defined on the basis of abnormalities in neural circuits and a fundamental cognitive process. This type of unitary model may be more heuristic than early ones that were based on heterogeneous signs and symptoms.
authors.affiliation: University of Iowa Hospitals and Clinics, Mental Health Clinical Research Center, 2911 JPP, 200 Hawkins Drive, Iowa City, IA, USA. nancy-andreasen@uiowa.edu
authors.forename: N C
authors.initials: NC
authors.lastname: Andreasen
mesh_terms: D006801:Humans; D012559:Schizophrenia / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology