Enantiomeric separation of optically active pyridazinone derivatives by chiral HPLC.
Several 4,5-disubstituted 3(2H)-pyridazinone derivatives containing 2-hydroxymethylpyrrolidino moiety as a chiral building block were synthetized. Separation of enantiomers was carried out by chiral HPLC on Chiralcel OJ and OF columns. Mobile phases consisted of hexane, ethanol and 2-propanol. Chiralcel OJ column was capable of separating most of the enantiomeric pairs. For one type of compound. Chiralcel OF column was used for separation.
Bidló-Iglóy
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M
Institute for Drug Research, Budapest, Hungary.
Mátyus
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P
D019840:2-Propanol / Q000737:chemistry; D001565:Benzoates; D002482:Cellulose / Q000031:analogs & derivatives; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D000431:Ethanol / Q000737:chemistry; D006586:Hexanes / Q000737:chemistry; D009904:Optical Rotation; D011724:Pyridazines / Q000032:analysis / Q000302:isolation & purification*; D015203:Reproducibility of Results; D013237:Stereoisomerism; D013696:Temperature
D001565:Benzoates; D006586:Hexanes; D011724:Pyridazines; C090722:tris(4-methylbenzoate)cellulose; D000431:Ethanol; D002482:Cellulose; D019840:2-Propanol