Bench scale manufacture of multilamellar liposomes using a newly developed multistage pressure filtration device.
Liposomes are belonging to the modern kinds of drugs. They are facilitating the secure and well-targeted transport of substances inside the organism, and are gaining increasing importance in the pharmacological treatment of tumors and in gene-therapeutic strategies. Multilamellar liposomes have advantages to one-layer liposomes: the multiplicity of coats increases the effect of a reservoir and makes extremely prolonged releases of drugs possible. This study describes the aseptical manufacturing of different kinds of multilamellar liposomes. It has been shown that it is possible to produce liposome-suspensions with different shares of multilamellar liposomes in the scale of litres under aseptical circumstances using a newly constructed multi-stage-pressure-filtration-device.
Endruschat
J
J
G.O.T.-Gesellschaft für Therapieoptimierung und Targeting Entwicklungs mbH, Robert-Rössle-Str. 10, D-13125, Berlin, Germany.
Henschke
K
K
D004339:Drug Compounding / Q000295:instrumentation / Q000379:methods*; D005374:Filtration / Q000295:instrumentation*; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D011312:Pressure; D013535:Suspensions; D013696:Temperature
D008081:Liposomes; D013535:Suspensions