title: Cox-2 expression in retinoblastoma.
abstract: OBJECTIVE
  Cox-2, a prostaglandin synthase, is overexpressed in colorectal cancers and is involved in angiogenesis as well as in tumorigenesis. In this study, we investigate the expression of Cox-2 in retinoblastoma.
  
  
  METHODS
  Twenty-nine formalin-fixed retinoblastoma specimens were examined by the labeled-streptavidin-biotin method using anti-Cox-2 antibody.
  
  
  RESULTS
  Cox-2 positive immunoreactions were observed in 28 (96%) of 29 retinoblastomas specimens.
  
  
  CONCLUSIONS
  This preliminary study suggests the overexpression of Cox-2 in both differentiated and undifferentiated retinoblastoma and its possible role in tumorigenesis.
authors.affiliation: Department of Ophthalmology, Kobe University School of Medicine, Kobe, Japan. zakir@fsbd.net
authors.forename: M M
authors.initials: MM
authors.lastname: Karim
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D002675:Child, Preschool; D051546:Cyclooxygenase 2; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D008565:Membrane Proteins; D010544:Peroxidases / Q000096:biosynthesis*; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis*; D019572:Retinal Neoplasms / Q000201:enzymology* / Q000473:pathology; D012175:Retinoblastoma / Q000201:enzymology* / Q000473:pathology
chemical_list: D007527:Isoenzymes; D008565:Membrane Proteins; D010544:Peroxidases; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases