title: PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation.
abstract: The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF 1163B by having an additional hydroxyl group on the side chain.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika, Ltd., Yokohama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: H
authors.initials: H
authors.lastname: Nose
authors.forename: A
authors.initials: A
authors.lastname: Hosoya
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Usui
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: T
authors.initials: T
authors.lastname: Shomura
authors.forename: S
authors.initials: S
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Tatsuta
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry*; D047028:Macrocyclic Compounds; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010407:Penicillium; D013237:Stereoisomerism
chemical_list: D000935:Antifungal Agents; D047028:Macrocyclic Compounds; C405057:PF 1163A; C405058:PF 1163B