title: The effect of anthocyanosides in a multiple oral dose on night vision.
abstract: OBJECTIVE
  In view of research demonstrating the ability of anthocyanosides in a multiple oral dose to improve night vision in normal individuals, we assessed their effect on three night vision tests: full-field absolute scotopic retinal threshold (SRT), dark adaptation rate (DAR) and mesopic contrast sensitivity (MCS).
  
  
  METHODS
  In a double-masked, placebo-controlled, cross-over study, 18 young normal volunteers were randomly assigned to one of three different regimens of multiple oral administrations of 12 and 24 mg anthocyanosides, and a placebo, given twice daily for 4 days. A 2 week washout period was allowed between each 4 day treatment period. SRT, DAR and MCS was tested 1 day before and at days 1, 2, 3 and 4 during the treatment period.
  
  
  RESULTS
  No significant effect was found on any of the three above-mentioned night vision tests. The study had a power of 0.95 to detect a 0.1 log unit improvement in SRT and 0.5 log unit improvement in MCS.
  
  
  CONCLUSIONS
  Multiple oral administrations of 12 and 24 mg anthocyanosides twice a day appear to lack significant effect on night vision tests.
authors.affiliation: Department of Ophthalmology, Assaf Harofeh Medical Center, Tel Aviv University, Israel. dzadok@yahoo.com
authors.forename: D
authors.initials: D
authors.lastname: Zadok
authors.forename: Y
authors.initials: Y
authors.lastname: Levy
authors.forename: Y
authors.initials: Y
authors.lastname: Glovinsky
mesh_terms: D000328:Adult; D000872:Anthocyanins / Q000008:administration & dosage / Q000494:pharmacology*; D015350:Contrast Sensitivity / Q000187:drug effects; D018592:Cross-Over Studies; D003623:Dark Adaptation / Q000187:drug effects; D003624:Darkness; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D012684:Sensory Thresholds / Q000187:drug effects; D014785:Vision, Ocular / Q000187:drug effects*
chemical_list: D000872:Anthocyanins; D010936:Plant Extracts