title: Detection and importance of laxative use in adolescents with anorexia nervosa.
abstract: OBJECTIVE
  The frequency of laxative use in adolescents with anorexia nervosa is poorly described. This study of adolescents with anorexia nervosa examined self-report and biochemical screening methods for the detection of laxative use, the pattern of laxative use in this population over time, and the associated medical complications and psychopathology.
  
  
  METHODS
  Forty-three consecutive patients with anorexia nervosa were studied. Initial assessment encompassed psychiatric history, medical examination, and administration of the Eating Disorders Examination, Child Behavior Checklist, and Youth Self-Report. Biochemical investigations, including random urinary laxative screening, were performed at assessment and follow-up.
  
  
  RESULTS
  The frequency of laxative use from self-report alone was 12%; combined with urine screening it was 19%. The frequency of laxative use increased to 32% with prospective follow-up. Medical complications were associated with laxative use at follow-up. Laxative use was associated with longer duration of disease and with higher scores on the Eating Disorders Examination subscale Eating Concern.
  
  
  CONCLUSIONS
  Laxative use is common among adolescents with anorexia nervosa, and the risk of associated medical complications increases over time. Biochemical screening will improve detection of laxative use. Longer duration of illness and greater Eating Concern scores are associated with increased risk of laxative use, and monitoring patients at increased risk is important.
authors.affiliation: Princess Margaret Hospital for Children, Perth, Western Australia.
authors.forename: J
authors.initials: J
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Batik
authors.forename: L J
authors.initials: LJ
authors.lastname: Palmer
authors.forename: D
authors.initials: D
authors.lastname: Forbes
authors.forename: B M
authors.initials: BM
authors.lastname: McDermott
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000175:diagnosis* / Q000523:psychology / Q000652:urine; D002400:Cathartics / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010555:Personality Inventory / Q000706:statistics & numerical data; D011379:Prognosis; D011594:Psychometrics; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology / Q000652:urine; D014904:Western Australia
chemical_list: D002400:Cathartics