Superoxide anion production by neutrophils derived from peripheral blood of schizophrenic patients.
Evidence indicates that excess free radicals formation may occur in patients with schizophrenia. A study comparing the production of superoxide anion by peripheral blood neutrophils of 29 schizophrenic patients with that of 17 healthy volunteers detected a significant statistical increase in superoxide anion production in schizophrenic patients compared to the healthy control group. Despite the fact that oxidative mechanisms may play a role in schizophrenia, further studies are needed to define their involvement. Such studies would shed light on the etiology and pathogenesis of schizophrenia and may lead to new therapeutic approaches using antioxidants, which might partially alleviate or prevent the symptoms of schizophrenia.
Melamed
Y
Y
Abarbanel Mental Health Center, Bat-Yam, Israel.
Sirota
P
P
Dicker
D R
DR
Fishman
P
P
D000293:Adolescent; D000328:Adult; D005260:Female; D005609:Free Radicals; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D011569:Psychiatric Status Rating Scales; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*; D013481:Superoxides / Q000378:metabolism*
D005609:Free Radicals; D017382:Reactive Oxygen Species; D013481:Superoxides