The effect of dexamethasone pretreatment on chlordiazepoxide and oxazepam levels in rat plasma.
The effect of dexamethasone pretreatment on the level of chlordiazepoxide and oxazepam was examined in the plasma of rats administered with 80 mg/kg of chlorodiazepoxide per os. The concentration of free chlordiazepoxide and unconjugated oxazepam was determined by HPLC method after solid-phase extraction. Pretreatment with dexamethasone significantly increased chlordiazepoxide plasma level 3, 6 and 12 hrs after ingestion, however increase of oxazepam concentration was not statistically significant. AUC 1-24 h after dexamethasone was elevated, for chlordiazepoxide and for oxazepam.
Osicka-Koprowska
A
A
Department of Toxicology, Warsaw Medical University, Poland.
Wasilewska
R
R
D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood*; D002707:Chlordiazepoxide / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D010076:Oxazepam / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
D014151:Anti-Anxiety Agents; D005938:Glucocorticoids; D010076:Oxazepam; D002707:Chlordiazepoxide; D003907:Dexamethasone