Formation of mineralized scar tissue induced by implants containing collagen-calcium phosphate gel.
The ability of a collagen-calcium phosphate gel to induce physiologic closure of subcutaneous polyethylene tube implants was tested. The openings of several tubes that had been filled with the gel were occluded by scars of mineralized connective tissue. Differentiation of cells into palisading fibroblasts and elaboration of a linear collagen matrix at the tissue-gel interface was seen.
Nevins
A
A
Division of Endodontics, Nassau County Medical Center, East Meadow, NY 11554, USA.
Finkelstein
F
F
Borden
B G
BG
Moodnik
R
R
D000818:Animals; D002130:Calcium Phosphates / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D002921:Cicatrix; D003094:Collagen / Q000494:pharmacology*; D003238:Connective Tissue / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects; D020007:Implants, Experimental; D011193:Potassium Iodide / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000187:drug effects
D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D011193:Potassium Iodide; C485838:calcium phosphate, monobasic, anhydrous; D003094:Collagen; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous