Computational modeling of the baroreflex arc: nucleus tractus solitarius.
In this study, we examine the utility of computational modeling in understanding nervous system function. We start by examining the reasons for, and major approaches to, computational modeling. We then chose a modeling approach and applied different variations to understanding nucleus tractus solitarius (NTS) neuronal responses to various baroreceptive stimuli. We examine the results in light of our objectives and with regard to the known parameters of the system under investigation. Our results demonstrate that modeling can be a useful tool in analysis of (and examination of underlying mechanisms for) NTS behavior on many levels.
Rogers
R F
RF
Central Research and Development, E.I. Du Pont De Nemours and Co., Inc., Wilmington, DE 19880-0328, USA. rfr@eplrx7.es.dupont.com
Rybak
I A
IA
Schwaber
J S
JS
D000818:Animals; D017704:Baroreflex / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology; D011311:Pressoreceptors / Q000166:cytology / Q000502:physiology*; D017552:Solitary Nucleus / Q000166:cytology / Q000502:physiology*