title: Efficacy evaluations of the use of oral tilmicosin in pneumonic calves.
abstract: The therapeutic effect of oral tilmicosin was compared with enrofloxacin, and the efficacy of three doses of the drug was examined in two fully randomized blinded field trials. Pneumonic milk-fed calves between 3 days and 2.5 months of age were allocated into two groups in trial 1 (50 animals) and into three groups in trial 2 (69 calves). In the first trial, the animals were treated with 25 mg/kg/day tilmicosin or 2.5 mg/kg/day enrofloxacin in milk for 5 days. In the second trial, the calves received either 25 mg/kg/day tilmicosin for 5 days or 3 days, or else 12.5 mg/kg tilmicosin for 5 days. All calves were clinically examined for 10 days. In the first trial, oral tilmicosin at a dose of 25 mg/kg/day for 5 days proved to be effective for the treatment of endemic pasteurellosis of milk-fed calves. The efficacy was the same as that of enrofloxacin. All three doses in the second trial were effective and were statistically equivalent to the original dose tested.
authors.affiliation: Department of Microbiology and Infectious Diseases, University of Veterinary Science, Budapest, H-1581, Hungary. fodor@novell.vmri.hu
authors.forename: L
authors.initials: L
authors.lastname: Fodor
authors.forename: L
authors.initials: L
authors.lastname: Reeve-Johnson
authors.forename: A
authors.initials: A
authors.lastname: Hodge
authors.forename: J
authors.initials: J
authors.lastname: Varga
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones; D018942:Macrolides; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000662:veterinary*; D015363:Quinolones / Q000008:administration & dosage*; D016896:Treatment Outcome; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides; D015363:Quinolones; D000077422:Enrofloxacin; C052319:tilmicosin; D015645:Tylosin