A review and proposed nomenclature for major proteins of the milk-fat globule membrane.
The characteristics and possible functions of the most abundant proteins associated with the bovine milk-fat globule membrane are reviewed. Under the auspices of the Milk Protein Nomenclature Committee of the ADSA, a revised nomenclature for the major membrane proteins is proposed and discussed in relation to earlier schemes. We recommend that proteins be assigned specific names as they are identified by molecular cloning and sequencing techniques. The practice of identifying proteins according to their Mr, electrophoretic mobility, or staining characteristics should be discontinued, except for uncharacterized proteins. The properties and amino acid sequences of the following proteins are discussed in detail: MUC1, xanthine dehydrogenase/oxidase, CD36, butyrophilin, adipophilin, periodic acid Schiff 6/7 (PAS 6/7), and fatty acid binding protein. In addition, a compilation of less abundant proteins associated with the bovine milk-fat globule membrane is presented.
Mather
I H
IH
Department of Animal and Avian Sciences, University of Maryland, College Park 20742, USA. im2@umail.umd.edu
D000595:Amino Acid Sequence; D000818:Animals; D000071797:Butyrophilins; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics; D002417:Cattle; D050556:Fatty Acid-Binding Proteins; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics; D008892:Milk / Q000737:chemistry*; D008894:Milk Proteins / Q000737:chemistry* / Q000235:genetics; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry / Q000235:genetics; D018996:Myelin P2 Protein / Q000737:chemistry / Q000235:genetics; D009363:Neoplasm Proteins; D010455:Peptides / Q000737:chemistry / Q000235:genetics; D000070780:Perilipin-2; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D009626:Terminology as Topic; D014968:Xanthine Dehydrogenase / Q000737:chemistry / Q000235:genetics
D000071797:Butyrophilins; D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D008894:Milk Proteins; D009077:Mucins; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D010455:Peptides; D000070780:Perilipin-2; D014968:Xanthine Dehydrogenase