Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum.
The antibothropic fraction (ABF) already isolated from Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv.
Rocha
S L
SL
Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.
Frutuoso
V S
VS
Domont
G B
GB
Martins
M A
MA
Moussatché
H
H
Perales
J
J
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000997:Antivenins / Q000097:blood / Q000627:therapeutic use*; D001381:Azepines / Q000627:therapeutic use; D017837:Bothrops; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D003907:Dexamethasone / Q000627:therapeutic use; D006930:Hyperalgesia / Q000139:chemically induced* / Q000517:prevention & control*; D007213:Indomethacin / Q000627:therapeutic use; D009893:Opossums / Q000097:blood*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D014230:Triazoles / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000997:Antivenins; D001381:Azepines; D003435:Crotalid Venoms; D010975:Platelet Aggregation Inhibitors; D014230:Triazoles; D003907:Dexamethasone; C063964:bepafant; D007213:Indomethacin