title: Thyroid structure and size and two-year follow-up of solitary cold thyroid nodules in an unselected population with borderline iodine deficiency.
abstract: OBJECTIVE
  Multinodular goitre has been found with a high prevalence in iodine-deficient areas, but less frequently in iodine-replete areas; the iodine intake sufficient to prevent goitre has not been established, however.
  
  
  METHODS
  We report data from an ultrasonic investigation of the thyroid glands of 2656 randomly selected subjects aged 41 to 71 years in an area with borderline iodine deficiency.
  
  
  RESULTS
  Median iodine concentration in spot urine samples was 70microg/l. Multinodular thyroid structure was found in 23% of the population, increasing in women from 20 to 46% with increasing age, and in men from 7 to 23%. Solitary, scintigraphically cold, thyroid nodules >10mm were found in 2.4% of the population with the same prevalence in the different age and sex groups. Two years of follow-up of these cold nodules revealed no signs of malignancies. Median thyroid volume was 11.0ml. Thyroid enlargement (>18ml for women and >25ml for men) was found among 13. 1% of the women and 6.2% of the men, and the prevalence increased with age. The presence of thyroid nodules was related to positive anti-thyroperoxidase antibody (TPO Ab) titres, whereas thyroid enlargement was associated with iodine excretion <50microg/day.
  
  
  CONCLUSIONS
  Thyroid enlargement was associated with low iodine excretion and median thyroid volume was slightly increased compared with iodine-replete areas. Multinodular thyroid structure was found with a high prevalence and was associated with TPO Ab >200kU/l. Cold thyroid nodules were moderately prevalent, with no cases of detected malignancies during 2 years of follow-up.
authors.affiliation: Department of Internal Medicine I, Bispebjerg Hospital, Copenhagen, Denmark. nils.knudsen@dadlnet.dk
authors.forename: N
authors.initials: N
authors.lastname: Knudsen
authors.forename: H
authors.initials: H
authors.lastname: Perrild
authors.forename: E
authors.initials: E
authors.lastname: Christiansen
authors.forename: S
authors.initials: S
authors.lastname: Rasmussen
authors.forename: H
authors.initials: H
authors.lastname: Dige-Petersen
authors.forename: T
authors.initials: T
authors.lastname: Jørgensen
mesh_terms: D000328:Adult; D000368:Aged; D003677:Deficiency Diseases / Q000473:pathology; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007455:Iodine / Q000172:deficiency*; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D011877:Radionuclide Imaging; D016606:Thyroid Nodule / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D007455:Iodine