[Influence of the presence of hot flashes during menopause on the metabolism of nitric oxide. Effects of hormonal replacement treatment].
BACKGROUND
To asses if the hot flushes during the menopause are associated to alterations in the metabolism of nitric oxide, total antioxidant activity and other biochemical parameters. To evaluate the effect of hormone replacement therapy (HRT) in the metabolism of nitric oxide, total antioxidant activity and biochemistry in menopausal women with and without hot flushes.


METHODS
Experimental study. This study included 29 healthy menopausal women with hot flushes (12 with HRT) and 20 without them (6 with HRT), 45-55 years old, with duration of menopause ranging from 1 to 5 years. Control group included 14 fertile women. Determinations of estradiol, nitrite-nitrate, total antioxidant activity and basic analytic, were performed before previous and after 4-6 month of HRT therapy.


RESULTS
Previously to HRT, hot flushes were associated to smaller level of total antioxidant activity (p < 0.05) in plasma, without differences in nitrite-nitrate concentrations. HRT was associated to increase in total antioxidant activity level and nitrite-nitrate concentrations (p < 0.05) in menopausal women, with and without hot flushes.


CONCLUSIONS
Hot flushes during the menopause indicate a high level of oxidative stress and a higher cardiovascular risk. HRT decreased the oxidative stress level and increased the nitric oxide derivate metabolites in menopausal women with and without hot flushes.
Leal Hernández
M
M
Departamento de Fisiología y Farmacología, Facultad de Medicina, Universidad de Murcia.
Abellán Alemán
J
J
Carbonell Meseguer
L F
LF
Díaz Fernández
J
J
García Sánchez
F A
FA
Martínez Selva
J M
JM
D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D019584:Hot Flashes / Q000378:metabolism*; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D008593:Menopause / Q000187:drug effects* / Q000378:metabolism*; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism*; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D045167:Progesterone Congeners / Q000008:administration & dosage; D012307:Risk Factors; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D000975:Antioxidants; D001786:Blood Glucose; D009566:Nitrates; D009573:Nitrites; D045167:Progesterone Congeners; D012709:Serum Albumin; D014280:Triglycerides; D009569:Nitric Oxide; D004958:Estradiol; D002784:Cholesterol; D017258:Medroxyprogesterone Acetate; D001663:Bilirubin