title: Genetic dissection of Plasmodium falciparum blood infection levels and other complex traits related to human malaria infection.
abstract: There is accumulating evidence of host genetic control in malaria infection and, in humans, some genes have been associated with severe malaria. Nevertheless, other important genes controlling blood infection levels, malarial disease and immune responses are likely to be identified. In this paper, we focus on segregation and linkage analyses of blood infection levels in an urban population living in Burkina Faso. We found evidence of a complex genetic control and a linkage to chromosome 5q31-q33. The identification of genes controlling complex traits related to malaria infection should be helpful in understanding protective mechanisms and the relationship between infection, malaria attacks and severe malaria.
authors.affiliation: Université de la Méditerranée, Faculté des Sciences de Luminy, Marseille, France. rihet@luminy.univ-mrs.fr
authors.forename: P
authors.initials: P
authors.lastname: Rihet
authors.forename: Y
authors.initials: Y
authors.lastname: Traoré
authors.forename: C
authors.initials: C
authors.lastname: Aucan
authors.forename: T
authors.initials: T
authors.lastname: Traoré-Leroux
authors.forename: B
authors.initials: B
authors.lastname: Kumulungui
authors.forename: A S
authors.initials: AS
authors.lastname: Traoré
authors.forename: L
authors.initials: L
authors.lastname: Abel
authors.forename: F
authors.initials: F
authors.lastname: Fumoux
mesh_terms: D000367:Age Factors; D000818:Animals; D002871:Chromosome Banding; D002895:Chromosomes, Human, Pair 5; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000235:genetics* / Q000469:parasitology*; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics*; D012621:Seasons