title: Medial temporal lobe width on CT scanning in Alzheimer's disease: comparison with vascular dementia, depression and dementia with Lewy bodies.
abstract: A simple linear measurement of the minimum width of the medial temporal lobe (MTL) on angled CT scans has been suggested as an accurate ante-mortem marker for Alzheimer's disease (AD). To determine the clinical utility and specificity of this finding, we performed angled CT scans with 5-mm slices in 116 subjects referred to a geographically based Old Age Psychiatry service in Newcastle. Diagnoses were of NINCDS/ADRDA AD (n = 69, 36 probable and 33 possible). NINDS/AIREN vascular dementia (VaD, n = 25), consensus criteria for dementia with Lewy bodies (DLB, n = 9) and DSM-IV criteria for major depression (n = 13). Subjects were well matched for age. Minimum MTL width was significantly greater in depressed subjects (13.7 mm) compared to those with dementia, though no differences were seen within the dementia groups (AD 10.8, VaD 10.4, and DLB 10.9 mm). An MTL width below 11.5 mm had a sensitivity of 54% (56/103) and a specificity of 77% (10/13) for distinguishing dementia from depression. We conclude that a single cross-sectional measurement of MTL width on CT does not help differentiate between different types of dementia, though it may provide some supportive evidence when distinguishing depression from dementia.
authors.affiliation: Institute for the Health of the Elderly, University of Newcastle-upon-Tyne, Glasgow, UK. j.t.o'brien@ncl.ac.uk
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
authors.forename: S
authors.initials: S
authors.lastname: Metcalfe
authors.forename: A
authors.initials: A
authors.lastname: Swann
authors.forename: J
authors.initials: J
authors.lastname: Hobson
authors.forename: K
authors.initials: K
authors.lastname: Jobst
authors.forename: C
authors.initials: C
authors.lastname: Ballard
authors.forename: I
authors.initials: I
authors.lastname: McKeith
authors.forename: A
authors.initials: A
authors.lastname: Gholkar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D015140:Dementia, Vascular / Q000000981:diagnostic imaging*; D003866:Depressive Disorder / Q000473:pathology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology*; D008297:Male; D013702:Temporal Lobe / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed