Measuring arterial strain induced by endovascular stents.
Endovascular stents are expandable, fenestrated tubes that are threaded in their collapsed state through an artery to a site of occlusion, plastically enlarged and left as permanent implants to scaffold the artery open. The stent induces large-scale vascular strains that are difficult to measure in vivo and yet can be critical determinants of stent-vessel biology. A method is developed to measure the strain tensor developed on the surface of an artery as a stent is expanded in vivo. Arterial sections are marked with reference points and imaged as the stent is expanded. An axially symmetric parametric model of the artery is determined for each expansion time-point, and these reference points are back-projected onto this surface. The back-projected reference points are grouped and analysed to determine the circumferential, axial and torsional strain tensor components in each arterial subsection. The method is characterised in vitro using bovine artery segments and a latex phantom, and is then tested on rabbits to demonstrate its feasibility in vivo. In vitro experiments on stented bovine arteries show typical post-stenting strains of 0.60, -0.26, and 0.08 mm mm-1 in the circumferential, axial and torsional directions, respectively, sampled every 1 mm along the length of the stented region. Phantom experiments characterise the RMS error of system measurements as 0.1 mm mm-1. The system is shown capable of measuring strains of straight, accessible vessels in the presence of respiratory/cardiac motion and visual glare in vivo.
Squire
J C
JC
Department of Electrical Engineering & Computer Science, Massachusetts Institute of Technology, Cambridge, USA. jcsquire@mit.edu
Rogers
C
C
Edelman
E R
ER
D000818:Animals; D001158:Arteries / Q000502:physiology*; D002417:Cattle; D005240:Feasibility Studies; D006801:Humans; D066298:In Vitro Techniques; D019047:Phantoms, Imaging; D011817:Rabbits; D015607:Stents; D013314:Stress, Mechanical