title: N-myristoyltransferase.
abstract: Myristoylation refers to the co-translational addition of a myristoyl group to an amino-terminal glycine residue of a protein by an ubiquitously distributed enzyme myristoyl-CoA:protein N-myristoyltransferase (NMT, EC 2.3.1.97). This review describes the basic enzymology, molecular cloning and regulation of NMT activity in various pathophysiological processes such as colon cancer and diabetes.
authors.affiliation: Department of Pathology and Saskatoon Cancer Centre, College of Medicine, Royal University Hospital, University of Saskatchewan, Canada.
authors.forename: R V
authors.initials: RV
authors.lastname: Rajala
authors.forename: R S
authors.initials: RS
authors.lastname: Datla
authors.forename: T N
authors.initials: TN
authors.lastname: Moyana
authors.forename: R
authors.initials: R
authors.lastname: Kakkar
authors.forename: S A
authors.initials: SA
authors.lastname: Carlsen
authors.forename: R K
authors.initials: RK
authors.lastname: Sharma
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism; D000217:Acyltransferases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism; D000230:Adenocarcinoma / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000378:metabolism; D004792:Enzyme Precursors / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007700:Kinetics; D008969:Molecular Sequence Data; D015688:Oncogene Protein pp60(v-src) / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D000214:Acyl Coenzyme A; D004792:Enzyme Precursors; C040349:S-tetradecanoyl-coenzyme A; D000217:Acyltransferases; C050480:glycylpeptide N-tetradecanoyltransferase; D015688:Oncogene Protein pp60(v-src); D002154:Calpain; C098484:mu-calpain proenzyme; D002118:Calcium