A preliminary study on intravenous infusion of sodium eicosapentaenoate.
Eicosapentaenoic acid (EPA) and arachidonic acid (AA), made into sodium salt solution (50 micrograms/ml), were used for intravenous infusion. In a preclinical study in dogs, Na-EPA lowered the activity of transminases (glutamic pyruvic transaminase [GPT], glytamic oxaloacetic transaminase [GOT]); however, Na-AA increased the activity of GPT and GOT. In the clinical study, the numbers of leukocytes and lymphocytes of volunteers increased and remained at that level for 3 to 5 days after intravenous infusion. The study indicated that an intravenous infusion of Na-EPA may have anti-inflammatory and immunomodulatory effects.
Liu
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Y
Department of Surgery, Rui-Jin Hospital, Shanghai No. 2 Medical University, China.
Chen
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D
D000818:Animals; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage* / Q000494:pharmacology*; D005395:Fish Oils; D006801:Humans; D007249:Inflammation; D007262:Infusions, Intravenous; D007962:Leukocytes; D008214:Lymphocytes; D000637:Transaminases / Q000378:metabolism*
D005395:Fish Oils; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid; D000637:Transaminases