Secondary amines as new pharmacophores for macrofilaricidal drug design.
Several secondary amines exhibit promising macrofilaricidal response in vivo through oral route of administration against Acanthocheilonema viteae in which N-hexylcyclohexylamine (1) shows 100% macrofilaricidal activity while a tertiary amine such as 9 elicits predominantly microfilaricidal (93%) response.
Srivastava
S K
SK
Divisions of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Chauhan
P M
PM
Bhaduri
A P
AP
Murthy
P K
PK
Chatterjee
R K
RK
D000588:Amines / Q000627:therapeutic use*; D000818:Animals; D000969:Antinematodal Agents / Q000737:chemistry / Q000627:therapeutic use; D003514:Cyclohexylamines / Q000627:therapeutic use; D004153:Dipetalonema / Q000187:drug effects; D015195:Drug Design; D005260:Female; D005368:Filariasis / Q000188:drug therapy; D005369:Filaricides / Q000737:chemistry / Q000627:therapeutic use*; D008297:Male; D009115:Muridae / Q000469:parasitology; D013329:Structure-Activity Relationship
D000588:Amines; D000969:Antinematodal Agents; D003514:Cyclohexylamines; D005369:Filaricides