[The effect of serum TGFb1 of patients with chronic hepatitis B in liver fibrosis formation].
OBJECTIVE
To observe the relation between serum transforming growth factor beta 1(TGF beta 1) and level of PCIII, LN, HA, proliferation of hepatic fibrotic tissue.


METHODS
Serum TGF beta 1 was detected by ELISA in 58 patients with chronic hepatitis B(CHB) and 18 patients with liver cirrhosis(LC). 20 healthy persons served as normal control(NC). Liver puncture was performed in 29 patients with CHB. Diagnosis of pathological histology and quantitative analysis of collagenous and reticular fibers were made.


RESULTS
(1)Serum TGF beta 1 levels in CHB and LC were notably higher than in NC (P < 0.01) and increased successively in mild, moderate and severe degrees of CHB and LC(P < 0.01/0.05). (2)Serum TGF beta 1 was correlated with serum levels of PCIII, LN, HA(P < 0.01/0.05)positively. The quantity of hepatic collagenous and reticular fibers went up in mild, moderate and severe degrees of CHB(P < 0.01/0.05). Meanwhile serum TGF beta 1 rose at the same degree.


CONCLUSIONS
Serum TGF beta 1 levels increase in CHB and LC. With hepatic pathological change worsening, serum TGF beta 1 and the quantity of hepatic collagenous and reticular fibers increased to the same degree. This suggests that TGF beta 1 is a crucial factor in accelerating liver fibrosis and plays a decisive role in liver fibrosis.
Liu
F
F
Department of Infectious Disease, Third Hospital of Hebei Medical University, Shijiazhuang.
Li
B
B
Nan
Y
Y
D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000097:blood*
D016212:Transforming Growth Factor beta