Ion channels and the control of blood pressure.
Ion channels exist in all cells and are enormously varied in structure, function and regulation. Some progress has been made in understanding the role that ion channels play in the control of blood pressure, but the discipline is still in its infancy. Ion channels provide many different targets for intervention in disorders of blood pressure and exciting advances have been made in this field. It is possible that new drugs, as well as antisense nucleotide technology or gene therapy directed towards ion channels, may form a new class of treatments for high and low blood pressure in the future.
Baker
E H
EH
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London, UK. ebaker@sghms.ac.uk
D001794:Blood Pressure / Q000502:physiology*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects; D011487:Protein Conformation
D002121:Calcium Channel Blockers; D007473:Ion Channels