title: Palmoplantar hyperkeratosis in Irish terriers: evidence of autosomal recessive inheritance.
abstract: An abnormal development of the epidermis of the footpad was observed in Irish terriers. At the age of six months, the affected animals developed smooth parchment-like footpads. The pad epidermis then hardened and grew lateral cone-like protrusions of up to 5 mm in diameter. Fissures and cracks developed and these predisposed the animal to secondary infection. The repeated occurrence in subsequent generations led to the assumption of a hereditary form of hyperkeratosis. Evidence for an autosomal recessive mode of inheritance was derived from a retrospective analysis of the breeder's records. The clinical, histopathological and ultrastructural features of the disease are presented and the genetic transmission and its implications discussed.
authors.affiliation: Department of Reproduction, Faculty of Veterinary Medicine, University of Zürich, Switzerland.
authors.forename: H
authors.initials: H
authors.lastname: Binder
authors.forename: S
authors.initials: S
authors.lastname: Arnold
authors.forename: C
authors.initials: C
authors.lastname: Schelling
authors.forename: M
authors.initials: M
authors.lastname: Suter
authors.forename: P
authors.initials: P
authors.lastname: Wild
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology; D004285:Dogs; D005260:Female; D005528:Foot / Q000473:pathology; D007645:Keratoderma, Palmoplantar / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010375:Pedigree