title: Endovascular healing is inadequate for fixation of Dacron stent-grafts in human aortoiliac vessels.
abstract: BACKGROUND
  migration and kinking of stent-grafts can occur late after endovascular aneurysm repair. It is unknown if endovascular grafts incorporate enough to be permanently anchored. In this report, healing of aortic stent-grafts was assessed in humans.
  
  
  METHODS
  we retrieved 23 Dacron stent-grafts from patients treated for an aortic aneurysm since 1993. Twelve stent-grafts were explanted at late conversion to open repair and 11 at autopsy. The deaths were unrelated to graft fixation. The median age of the patients was 74 years (IQR 55-84 years) and the grafts were explanted 9 months (1-31 months) after insertion. Microscopic slides were prepared by conventional techniques or by cutting and grinding arterial specimens embedded in plastic with the stent-grafts in situ.
  
  
  RESULTS
  the stent-grafts detached readily from the native arteries at surgery or autopsy, except when the stents had hooks or barbs which engaged the vessel wall. A space filled with poorly organised blood components persisted between the graft and the aortic wall 2.5 years after implantation. No firm incorporation of the grafts was observed proximally in the aneurysm neck or distally in the iliac segment. A friable neo-intimal layer covered parts of the luminal aspect of the grafts.
  
  
  CONCLUSIONS
  endovascular healing provides poor fixation of Dacron stent-grafts in humans. At present, fixation relies on the mechanical properties of the stent-grafts.
authors.affiliation: Department of Vascular Surgery, Malmö University Hospital, Malmö, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Malina
authors.forename: J
authors.initials: J
authors.lastname: Brunkwall
authors.forename: K
authors.initials: K
authors.lastname: Ivancev
authors.forename: J
authors.initials: J
authors.lastname: Jönsson
authors.forename: J
authors.initials: J
authors.lastname: Malina
authors.forename: B
authors.initials: B
authors.lastname: Lindblad
mesh_terms: D000368:Aged; D001012:Aorta, Abdominal / Q000473:pathology / Q000601:surgery; D001013:Aorta, Thoracic / Q000473:pathology / Q000601:surgery; D001807:Blood Vessel Prosthesis; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000473:pathology / Q000601:surgery; D008297:Male; D011093:Polyethylene Terephthalates; D015607:Stents; D014945:Wound Healing
chemical_list: D011093:Polyethylene Terephthalates