title: Regulation of signal transduction by endocytosis.
abstract: Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the co-localization of activated receptors with downstream signaling molecules.
authors.affiliation: Department of Cell Biology, IMM-11, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: B P
authors.initials: BP
authors.lastname: Ceresa
authors.forename: S L
authors.initials: SL
authors.lastname: Schmid
mesh_terms: D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases