title: Low molecular weight heparin after mechanical heart valve replacement.
abstract: BACKGROUND
  Patients with mechanical heart valves require life-long anticoagulation. We report here the first large and comparative series of consecutive patients anticoagulated with low molecular weight heparin (LMWH) after mechanical heart valve replacement.
  
  
  RESULTS
  In this comparative, nonrandomized study, 208 consecutive patients who underwent a single or double heart valve replacement with mechanical prostheses were anticoagulated subcutaneously with unfractionated heparin (UH) in the first period (n=106) and LMWH in the second phase (n=102) of the study. Baseline characteristics were similar in the 2 groups. The mean durations of UH and LMWH treatments were 13.6+/-0.5 and 14.1+/-0.6 days, respectively (not significant). On the second day of treatment, 87% of patients treated with LMWH had an anti-Xa activity within the range of efficacy (0.5 to 1 IU/mL), but only 9% of UH-treated patients had an activated partial-thromboplastin time value within the therapeutic range (1.5 to 2.5 times control, P<0.0001 between the 2 groups). On the last day of prescription, all LMWH-treated patients had anti-Xa activity above 0.5 IU/mL, but 19% were above 1 IU/mL. In the UH group, 27% of patients had an activated partial-thromboplastin time above 1.5 times control, but 62% were overanticoagulated. Two major bleedings occurred in each group, and one stroke occurred in the UH group.
  
  
  CONCLUSIONS
  In this first comparative study, anticoagulation with LMWHs after mechanical heart valve replacement appears feasible, provides adequate biological anticoagulation, and compares favorably with UH anticoagulation. Randomized studies are now needed to further evaluate this new therapeutic approach.
authors.affiliation: Departments of Cardiology, Pitié-Salpétrière Hospital, Paris, France. gilles.montalescot@psl.ap-hop-paris.fr
authors.forename: G
authors.initials: G
authors.lastname: Montalescot
authors.forename: V
authors.initials: V
authors.lastname: Polle
authors.forename: J P
authors.initials: JP
authors.lastname: Collet
authors.forename: P
authors.initials: P
authors.lastname: Leprince
authors.forename: A
authors.initials: A
authors.lastname: Bellanger
authors.forename: I
authors.initials: I
authors.lastname: Gandjbakhch
authors.forename: D
authors.initials: D
authors.lastname: Thomas
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D013927:Thrombosis / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin