Estrogens and euosteogenesis in men.
The bone mineral density (BMD) has been analyzed in 200 male patients divided in 4 groups of age as follows: (A) 40-49, (B) 50-59, (C) 60-69, and (D) 70 years and above. BMD was measured by using the DEXA technique both in the ultradistal and mediodistal region of radius of the non-dominant side. In addition, the serum levels of testosterone (Ts), dihydrotestosterone (DHT) and 17-beta estradiol (E-2) have also been measured. The data obtained have shown that bone mineral density values are decreasing also in the males with advancing age, and the positive correlation (p < 0.05) of BMD with the E-2 levels also tend to decrease. These results suggest the hypothesis that the true sexual hormones regulating the rhythm of osteogenesis may be the estrogens in the males, too.
Maugeri
D
D
Institute of Internal Medicine and Geriatrics, Catania University, Italy.
Panebianco
P
P
Barbagallo
P
P
Malaguarnera
M
M
Curasi
M P
MP
Russo
M S
MS
Santangelo
A
A
Speciale
S
S
Scarpinato
R A
RA
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D000728:Androgens / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000097:blood / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology / Q000503:physiopathology; D013739:Testosterone / Q000097:blood
D000728:Androgens; D004967:Estrogens; D013739:Testosterone; D004958:Estradiol