Bound and soluble adhesion molecule and cytokine levels in patients with severe burns.
We measured endotoxins, inflammatory cytokines and soluble adhesion molecules in the blood of 17 severe burn patients to determine the involvement of these factors in the pathophysiology of severe burns. All seventeen patients had burns with a total burn surface area of 20% or more and a burn index of 15% or more. Endotoxin was measured by an endotoxin-specific assay and tumor necrosis factor-alpha, interleukin 6 and interleukin 8 and soluble adhesion molecules were measured by enzyme-linked immunosorbent assay. CD11a, CD11b and CD18, measured by flow cytometry, were elevated in the non-surviving group, the septic shock group and the multiple organ dysfunction syndrome group, suggesting a close connection between these adhesion molecules and burns complicated by infection. Soluble adhesion molecules were found to indirectly reflect the level of endothelial cell adhesion molecules, suggesting that inflammatory cytokines may also be involved in their production.
Nakae
H
H
Department of Critical Care Medicine, Akita University, Medical School, Hondo, Japan.
Endo
S
S
Yamada
Y
Y
Inada
K
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood* / Q000401:mortality; D018845:CD11 Antigens / Q000097:blood; D018821:CD18 Antigens / Q000097:blood; D016207:Cytokines / Q000097:blood*; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012995:Solubility; D015996:Survival Rate; D015599:Trauma Severity Indices; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D015415:Biomarkers; D018845:CD11 Antigens; D018821:CD18 Antigens; D016207:Cytokines; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1