title: PU.1 expression in microglia.
abstract: The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in microglial regulation, we investigated its expression following hypoxic-ischemia (HI) brain injury and in the BV-2 microglial cell line. We found that microglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states.
authors.affiliation: Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand.
authors.forename: M R
authors.initials: MR
authors.lastname: Walton
authors.forename: H
authors.initials: H
authors.lastname: Gibbons
authors.forename: G A
authors.initials: GA
authors.lastname: MacGibbon
authors.forename: E
authors.initials: E
authors.lastname: Sirimanne
authors.forename: J
authors.initials: J
authors.lastname: Saura
authors.forename: P D
authors.initials: PD
authors.lastname: Gluckman
authors.forename: M
authors.initials: M
authors.lastname: Dragunow
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D002460:Cell Line; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism*; D007150:Immunohistochemistry; D017628:Microglia / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015534:Trans-Activators / Q000096:biosynthesis*; D015854:Up-Regulation; D000099232:Proto-Oncogene Protein Spi-1
chemical_list: D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1