Influence of different parameters on reconstitution of lyophilized SLN.
Drug-loaded solid lipid nanoparticles (SLN) suitable for parenteral administration were freeze-dried. The lipid matrix Imwitor 900 (concentration, 2.5%) was stabilized with Lipoid E 80 and sodium glycocholate. The influence of different parameters of lyophilization like the protective effect of cryoprotectants, freezing velocity, and thermal treatment was investigated. The results of this study demonstrate that, by optimizing critical process parameters, i.v.-injectable SLN-dispersions can be freeze-dried, preserving their small particle size.
Zimmermann
E
E
Department of Pharmaceutics, Biopharmaceutics and Biotechnology, The Free University of Berlin, Kelchstr. 31, D-12169, Berlin, Germany.
Müller
R H
RH
Mäder
K
K
D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D005612:Freeze Drying / Q000379:methods; D008055:Lipids / Q000737:chemistry*; D010316:Particle Size; D013053:Spectrophotometry / Q000379:methods
D004337:Drug Carriers; D008055:Lipids