[HBV transmission from father to foetus and HBV DNA in tissues outside the liver].
OBJECTIVE
To study the possibility of HBV Transmission from father to foetus and HBV DNA in tissues outside liver.


METHODS
Paired sera were from 8 HBV man carriers whose wives were negative for HBVM and 8 foetuses who were infected with HBV in the womb. S gene nt 451-660 nucleotide, C gene nt 2,022-2,321 nucleotide were directly sequenced.


RESULTS
The homology of HBV sequence between father and foetus was very high. The mutations of 491, 494, 530, 546 and 581 nucleotide in the S gene caused 113, 114, 126, 131 and 143 amino acid substitution. HBV DNA can be detected in the tissues outside liver of foetus.


CONCLUSIONS
HBV transmission from father to foetus may be present. HBV DNA in tissues outside liver of foetus can be detected.
Wang
S
S
Institute of Military Medicine, Guangzhou Command PLA.
Jiang
P
P
Peng
G
G
D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005333:Fetus / Q000821:virology*; D006509:Hepatitis B / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D018812:Paternal Exposure; D016133:Polymerase Chain Reaction; D011247:Pregnancy
D004279:DNA, Viral