title: Seroprevalence of human T-lymphotropic virus type 1 in Papua New Guinea and Irian Jaya measured using different western blot criteria.
abstract: BACKGROUND
  Endemic foci of HTLV-1 carriers have been found in the world, however, the origin of HTLV-1 in humans is still unclear. Since a distinct type of virus strain was isolated from the Solomon Islands, detailed surveys on HTLV-1 prevalence in New Guinea are important to shed light on its history of dissemination.
  
  
  OBJECTIVE
  To clarify the seroprevalence of HTLV-1 in different regions of New Guinea Island.
  
  
  METHODS
  Sera from 1221 individuals (649 males, 454 females and 118 unknown) in New Guinea Island were studied for the presence of antibodies to HTLV-1 by a particle agglutination and the Western blot (WB) tests. Two different sets of criteria, proposed by WHO and Kiyokawa et al., were employed to interpret the WB test. Since the latter seemed to lack adequate specificity, the WHO criteria was used for the evaluation of the seroprevalence throughout the study.
  
  
  RESULTS
  Seroprevalence of HTLV-1 differed by the WB criteria. By the more stringent criteria, HTLV-1 carriers were found in Madang, Chimbu and one hinterland province, Enga, in Papua New Guinea. An overall seroprevalence rate in different regions ranged from 0 to 14.6%. No seropositive individuals were found in Irian Jaya.
  
  
  CONCLUSIONS
  To avoid overestimating the seropositivity rates, the WHO criteria would be more appropriate to employ for WB test by using the samples obtained from tropical and/or malaria endemic areas. This study is the first to show HTLV-1 infected individuals in the hinterland of New Guinea Island.
authors.affiliation: Department of Anthropology, Unit of Human Biology and Genetics, Faculty of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takao
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: K K
authors.initials: KK
authors.lastname: Bhatia
authors.forename: N
authors.initials: N
authors.lastname: Saha
authors.forename: A
authors.initials: A
authors.lastname: Soemantri
authors.forename: O W
authors.initials: OW
authors.lastname: Kayame
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015153:Blotting, Western / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D015686:Gene Products, env / Q000276:immunology; D015683:Gene Products, gag / Q000276:immunology; D015490:HTLV-I Infections / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007223:Infant; D008297:Male; D008875:Middle Aged; D010219:Papua New Guinea / Q000453:epidemiology; D016036:Seroepidemiologic Studies
chemical_list: D015686:Gene Products, env; D015683:Gene Products, gag