title: Airway cross section strongly influences alveolar plateau slope of capnograms for smaller tidal volumes.
abstract: We compared the predictions of the single path convection-diffusion model (SPM) and the well-mixed single acinus model (SAM) with the normalized slopes (NS) of experimentally measured volumetric capnograms in which VT was varied in three healthy spontaneously breathing adults. For values of VT greater than 15 ml/kg, the tidal volume penetrates deep into the acinar airways, mixing by molecular diffusion is rapid and the predictions of the SAM and SPM both agree with the experiment. The SPM however shows much better agreement with the experimental NS data than does the SAM for values of VT less than 10 ml/kg. The explanation for the departure of the SAM from the observed experimental data, at small VT, is that it represents the limiting case (of well-mixed alveolar gas) for the SPM, only at large VT, where the assumption of rapid mixing is most accurate. We conclude that in general, gas phase diffusivity and total acinar airway cross sectional area variation with cumulative volume into the lung are essential to realistically model airway gas exchange between VT and FRC and to obtain agreement with experimental data under the widest range of breathing conditions.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia 19104-6392, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Huang
authors.forename: G C
authors.initials: GC
authors.lastname: Yang
authors.forename: P W
authors.initials: PW
authors.lastname: Scherer
authors.forename: G R
authors.initials: GR
authors.lastname: Neufeld
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology*; D008954:Models, Biological; D011650:Pulmonary Alveoli / Q000502:physiology*; D011659:Pulmonary Gas Exchange; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide