Melanin-concentrating hormone (MCH) modifies memory retention in rats.
The purpose of the present study was to evaluate the possible effect of melanin-concentrating hormone (MCH) on learning and memory by using the one-trial step-down inhibitory avoidance test in rats. The peptide was infused into hippocampus, amygdala, and entorhinal cortex. MCH caused retrograde facilitation when given at 0 or 4 h post-training into hippocampus, but only at 0 h into amygdala. From these results, it seems that MCH modulates memory early after training by acting on both the amygdala and hippocampus and, 4 h after training, on the hippocampus.
Monzon
M E
ME
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina. memonzon.epractica@mater.fcm.unc.edu.ar
de Souza
M M
MM
Izquierdo
L A
LA
Izquierdo
I
I
Barros
D M
DM
de Barioglio
S R
SR
D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D018728:Entorhinal Cortex / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007028:Hypothalamic Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008543:Melanins / Q000008:administration & dosage / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D010907:Pituitary Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007028:Hypothalamic Hormones; D008543:Melanins; D010907:Pituitary Hormones; C019463:melanin-concentrating hormone