Human breast cancer specimens: diffraction-enhanced imaging with histologic correlation--improved conspicuity of lesion detail compared with digital radiography.
Seven breast cancer specimens were examined with diffraction-enhanced imaging at 18 keV with a silicon crystal with use of the silicon 333 reflection in Bragg mode. Images were compared with digital radiographs of the specimen, and regions of increased detail were identified. Six of the seven cases (86%) showed enhanced visibility of surface spiculation that correlated with histopathologic information, including extension of tumor into surrounding tissue.
Pisano
E D
ED
Department of Radiology, UNC-Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill 27599-7510, USA. etpisano@med.unc.edu
Johnston
R E
RE
Chapman
D
D
Geradts
J
J
Iacocca
M V
MV
Livasy
C A
CA
Washburn
D B
DB
Sayers
D E
DE
Zhong
Z
Z
Kiss
M Z
MZ
Thomlinson
W C
WC
D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000473:pathology; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008327:Mammography / Q000295:instrumentation*; D011856:Radiographic Image Enhancement / Q000295:instrumentation*; D017356:Synchrotrons; D014961:X-Ray Diffraction / Q000295:instrumentation*