title: DNA rearrangements at the extremities of the Streptomyces ambofaciens linear chromosome: evidence for developmental control.
abstract: In Streptomyces, a genomic instability results from frequent recombination events which occur at the ends of the linear chromosomal DNA. These events are believed to be responsible for the variability observed in these regions among Streptomyces species and strains. In order to identify functions able to control this type of genome plasticity, mutators as well as mutants produced at different stages of development have been characterized in S. ambofaciens. Their characterization suggests the existence of a relationship between genomic instability and colony development.
authors.affiliation: Laboratoire de Génétique et Microbiologie, Faculté des Sciences de l'Université Henri-Poincaré, Nancy 1, France.
authors.forename: A
authors.initials: A
authors.lastname: Dary
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: T
authors.initials: T
authors.lastname: Wenner
authors.forename: B
authors.initials: B
authors.lastname: Decaris
authors.forename: P
authors.initials: P
authors.lastname: Leblond
mesh_terms: D002876:Chromosomes, Bacterial; D004269:DNA, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D015321:Gene Rearrangement; D016680:Genome, Bacterial; D009154:Mutation; D011995:Recombination, Genetic; D013302:Streptomyces / Q000235:genetics* / Q000254:growth & development
chemical_list: D004269:DNA, Bacterial