title: The role of Tc-99m (V) DMSA scintigraphy in the evaluation of superscan on bone scintigraphy.
abstract: OBJECTIVE
  This study evaluated the biodistribution of Tc-99m (V) DMSA in patients with superscans on bone imaging and defined its role in differentiating the underlying cause.
  
  
  METHODS
  Nine patients (five with metastatic and four with metabolic bone disease) with classical superscans were entered into the study. All patients had the necessary radiologic and biochemical studies and a final diagnosis was reached accordingly. Tc-99m (V) DMSA scintigraphy was performed 1 week after Tc-99m MDP whole-body bone imaging.
  
  
  RESULTS
  In four of five patients with widespread skeletal metastases, Tc-99m (V) DMSA scan showed diffusely increased bone uptake. In the remaining patient, the Tc-99m (V) DMSA scan showed a normal distribution pattern. All patients with metabolic bone disease had increased bone uptake on Tc-99m (V) DMSA scans.
  
  
  CONCLUSIONS
  Tc-99m (V) DMSA shows increased bone uptake in patients having a superscan appearance in metastatic or metabolic bone disease. Tc-99m (V) DMSA imaging may play a role in the evaluation of patients with equivocal bone scan findings for a superscan.
authors.affiliation: Pamukkale University Medical Faculty, Department of Nuclear Medicine, Denizli, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Yüksel
authors.forename: S
authors.initials: S
authors.lastname: Ilgan
authors.forename: N
authors.initials: N
authors.lastname: Arslan
authors.forename: O
authors.initials: O
authors.lastname: Uğur
authors.forename: E
authors.initials: E
authors.lastname: Oztürk
authors.forename: H
authors.initials: H
authors.lastname: Bayhan
mesh_terms: D000328:Adult; D000368:Aged; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid