title: The choroid plexuses and the barriers between the blood and the cerebrospinal fluid.
abstract: 1. The fluid homeostasis of the brain depends both on the endothelial blood-brain barrier and on the epithelial blood-cerebrospinal fluid (CSF) barrier located at the choroid plexuses and the outer arachnoid membrane. 2. The brain has two fluid environments: the brain interstitial fluid, which surrounds the neurons and glia, and the CSF, which fills the ventricles and external surfaces of the central nervous system. 3. CSF acts as a fluid cushion for the brain and as a drainage route for the waste products of cerebral metabolism. 4. Recent findings suggest that CSF may also act as a "third circulation" conveying substances secreted into the CSF rapidly to many brain regions.
authors.affiliation: Division of Physiology, Guy's, King's and St. Thomas' School of Biomedical Sciences, King's College London, UK. malcolm.segal@kcl.ac.uk
authors.forename: M B
authors.initials: MB
authors.lastname: Segal
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D002199:Capillary Permeability / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D002831:Choroid Plexus / Q000098:blood supply / Q000502:physiology*; D006801:Humans