[The immunological aspects of predicting antibiotic therapy efficacy in peritonitis patients].
The analysis of the impact of various group antibiotics on the mechanisms of development and correction of pathogenetically heterogeneous immune deficiency in 235 patients at age of 17 to 85 years with local (80 patients) and general (155 patients) peritonitis is presented. Cephalosporins and fluoroquinolones promoted restoration of the immune and interleukin (IL-1 and IL-2 of donors, IL-1r and IL-2r of patients) status and lowered the immunodepressive effect of glucocorticoids (GC) at the organism (cortisol, ACTH and cortisol-binding globulin) and cellular (GC receptors III) levels. Aminoglycosides and penicillins had no significant action on the immune and interleukin status but lowered the EG effect at the organism (aminoglycosides) and cellular (penicillins) levels. It is recommended that the antibiotics be used with an account of their involvement in the systemic reactions of the host.
Briskin
B S
BS
Chair of Surgical Diseases, Moscow Medical Institute of Stomatology.
Savchenko
Z I
ZI
Khachatrian
N N
NN
Evstifeeva
O V
OV
Nekrasova
N I
NI
Sosnovikova
O G
OG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007153:Immunologic Deficiency Syndromes / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D007375:Interleukin-1 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology; D011379:Prognosis
D000900:Anti-Bacterial Agents; D007375:Interleukin-1; D007376:Interleukin-2