title: Chronic anabolic-androgenic steroid treatment during adolescence increases anterior hypothalamic vasopressin and aggression in intact hamsters.
abstract: The present study examines the hypothesis that exposure to anabolic-androgenic steroids (AAS) during adolescent development predisposes hamsters to heightened levels of aggressive behavior by influencing the anterior hypothalamic-arginine vasopressin (AH-AVP) neural system. To test this, adolescent male hamsters (Mesocricetus auratus) were treated with high doses of AAS, tested for offensive aggression in the absence or presence of AH-AVP receptor antagonists, and then examined for changes in AH-AVP expression and neural organization. AAS exposure during adolescence significantly increased aggression intensity (number of attacks and bites) and initiation (latency to the first bite). Yet, only increases in aggression intensity were inhibited by AH-AVP receptor antagonism. Adolescent AAS-treated hamsters showed significant increases in AH-AVP fiber density and peptide content. However, no alterations in AH-AVP neuronal organization or mRNA expression were found. Together, these data suggest that adolescent AAS exposure increase aggression intensity by altering AH-AVP expression and activity, providing direct evidence for a causal role of AH-AVP expression and function in early onset AAS-stimulated aggression.
authors.affiliation: Department of Psychiatry, The University of Massachusetts Medical Center, 55 Lake Avenue, North, Worcester, MA 01655, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Harrison
authors.forename: D F
authors.initials: DF
authors.lastname: Connor
authors.forename: C
authors.initials: C
authors.lastname: Nowak
authors.forename: K
authors.initials: K
authors.lastname: Nash
authors.forename: R H
authors.initials: RH
authors.lastname: Melloni
mesh_terms: D000374:Aggression / Q000187:drug effects*; D045930:Anabolic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D006224:Cricetinae; D004797:Enzyme-Linked Immunosorbent Assay; D007032:Hypothalamus, Anterior / Q000737:chemistry / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008647:Mesocricetus; D009412:Nerve Fibers / Q000737:chemistry; D009474:Neurons / Q000737:chemistry; D012333:RNA, Messenger / Q000032:analysis; D017483:Receptors, Vasopressin / Q000502:physiology; D012741:Sexual Maturation
chemical_list: D045930:Anabolic Agents; D065092:Antidiuretic Hormone Receptor Antagonists; D012333:RNA, Messenger; D017483:Receptors, Vasopressin; D001127:Arginine Vasopressin