title: E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro.
abstract: The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.
authors.affiliation: Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, United Kingdom.
authors.forename: D W
authors.initials: DW
authors.lastname: Owens
authors.forename: V G
authors.initials: VG
authors.lastname: Brunton
authors.forename: E K
authors.initials: EK
authors.lastname: Parkinson
authors.forename: M C
authors.initials: MC
authors.lastname: Frame
mesh_terms: D015820:Cadherins / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion; D002450:Cell Communication; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011503:Transglutaminases / Q000378:metabolism
chemical_list: D015820:Cadherins; D011498:Protein Precursors; C032253:involucrin; D011503:Transglutaminases; D002118:Calcium