title: Production of N-acyl-L-homoserine lactones by P. aeruginosa isolates from chronic lung infections associated with cystic fibrosis.
abstract: The N-acyl-L-homoserine lactones (AHLs) produced by sequential Pseudomonas aeruginosa isolates from chronically infected patients with cystic fibrosis were analyzed by thin-layer chromatography. It is demonstrated that both the amounts and the types of molecules synthesized by isolates from patients who were monitored over periods of up to 11 years do not change significantly during chronic colonization. However, in the case of a patient who became co-infected with an AHL-producing Burkholderia cepacia strain a dramatic reduction in the amounts of AHLs produced by the co-residing P. aeruginosa isolates was observed.
authors.affiliation: Lehrstuhl für Mikrobiologie, Technische Universität München, Am Hochanger 4, D-85350, Freising, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Geisenberger
authors.forename: M
authors.initials: M
authors.lastname: Givskov
authors.forename: K
authors.initials: K
authors.lastname: Riedel
authors.forename: N
authors.initials: N
authors.lastname: Høiby
authors.forename: B
authors.initials: B
authors.lastname: Tümmler
authors.forename: L
authors.initials: L
authors.lastname: Eberl
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000096:biosynthesis; D019121:Burkholderia Infections / Q000382:microbiology; D016956:Burkholderia cepacia; D002855:Chromatography, Thin Layer; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000382:microbiology*; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008171:Lung Diseases / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: C088386:homoserine lactone; D015107:4-Butyrolactone