Thyroid transcription factor-1 is a marker of lung and thyroid carcinomas.
Thyroid transcription factor-1 (TTF-1) is a tissue specific transcription factor expressed in epithelial cells of the thyroid and lung, as well as in certain areas of the brain. Recent investigations have shown that TTF-1 is also commonly present in a wide variety of thyroid and lung tumors. Because of its restrictive expression, TTF-1 is a useful immunohistochemical marker in the diagnosis of tumors of thyroid or lung origin.
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University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000175:diagnosis; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D009687:Nuclear Proteins / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000175:diagnosis; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000032:analysis*
D014408:Biomarkers, Tumor; C000614412:NKX2-1 protein, human; D009687:Nuclear Proteins; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors