title: The relative frequencies of HLA-DRB1*01 alleles in the major US populations.
abstract: The frequencies of alleles in the HLA-DRB1*01 family were determined in each of five US populations from a database of 82,979 individuals. Individuals typed as DR1 (or DRB1*01) comprised between 7.6%-21.3% of the individuals in each population group. Fifty-nine DR1 individuals were randomly selected from each group and subjected to high-resolution DNA typing by polymerase chain reaction using sequence-specific oligonucleotide probes. DRB1*0101 was the most common allele in the Caucasian, Asian/Pacific Islander, and Native American groups while the DRB1*0102 allele was found in the majority of African Americans and Hispanics. DRB1*0103 was present at a similar frequency in all populations. DRB1*0104, DRB1*0105, and DRB1*0106 alleles were not observed.
authors.affiliation: Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Collins
authors.forename: T
authors.initials: T
authors.lastname: Tang
authors.forename: R
authors.initials: R
authors.lastname: Slack
authors.forename: D
authors.initials: D
authors.lastname: Sintasath
authors.forename: R J
authors.initials: RJ
authors.lastname: Hartzman
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D044469:Racial Groups / Q000235:genetics*; D014481:United States
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains