The utility of fibrin/fibrinogen degradation products in superficial bladder cancer.
Fibrin/fibrinogen degradation products are either absent or present at exceedingly low levels in the urine of healthy persons. Although various nonspecific inflammatory conditions of the urinary tract can result in detectable amounts of FDP in the urine, the presence of FDP is far more prevalent in urine from patients with bladder cancer. Urinary FDP levels tend to be higher in patients with tumors of increasing grade and stage. This correlation results in improved sensitivity in detecting more aggressive tumors. Current monoclonal antibody immunoassays are simple, rapid, and inexpensive, and can be performed on urine samples in the clinical setting. The overall accuracy of these immunoassays ranges from 75% to 80% (Table 1), suggesting that the urine FDP test should not be used alone for the surveillance of superficial bladder cancer. When assays for urine FDP are combined with urine cytology, the sensitivity for detecting tumors is improved. Prospective data are needed to determine whether using these tests in combination can safely permit a reduced frequency of endoscopic surveillance.
Tsihlias
J
J
Department of Urology, University of Texas M. D. Anderson Cancer Center, Houston, USA.
Grossman
H B
HB
D014408:Biomarkers, Tumor / Q000652:urine*; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000652:urine; D003937:Diagnosis, Differential; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine*; D005342:Fibrinolysis; D006801:Humans; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D012008:Recurrence; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000652:urine*; D014556:Urine / Q000166:cytology
D014408:Biomarkers, Tumor; D005338:Fibrin Fibrinogen Degradation Products