title: [Apudocytes and mast cells in chronic inflammation of colon: clinicomorphological correlations].
abstract: OBJECTIVE
  To study functional morphology of a total population of endocrine cells of colon mucosa, mast and enterochromaffine cells.
  
  
  METHODS
  Light and electrone microscopy, immunohistochemical methods, morphometry were used to study endocrine and mast cells of the sigmoid colon in inflammation.
  
  
  RESULTS
  Changes of functional morphology and size of endocrine and mast cell population as well as apudocytes producing serotonin, melatonin, vasointestinal peptides were stated. Apudocyte and mass cell functional morphology, clinical symptoms and mucosal structural changes correlated. Specificity of some parameters in Chron's disease is shown.
  
  
  CONCLUSIONS
  The results may provide additional criteria in diagnosis of different variants of chronic colitis.
authors.forename: I V
authors.initials: IV
authors.lastname: Kozlova
authors.forename: M A
authors.initials: MA
authors.lastname: Osadchuk
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Popuchiev
mesh_terms: D001078:APUD Cells / Q000378:metabolism / Q000648:ultrastructure*; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003092:Colitis / Q000378:metabolism / Q000473:pathology; D003424:Crohn Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000648:ultrastructure*; D008407:Mast Cells / Q000378:metabolism / Q000648:ultrastructure*; D008550:Melatonin / Q000378:metabolism; D008875:Middle Aged; D011379:Prognosis; D012701:Serotonin / Q000378:metabolism; D012810:Sigmoid Diseases / Q000378:metabolism / Q000473:pathology*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D008550:Melatonin