title: An autoradiographic study in mu-opioid receptor knockout mice.
abstract: An autoradiographic study was carried out to study the opioid binding sites in a mu-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. Mu-opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional mu-opioid receptor does not affect the expression of the other two opioid receptors.
authors.affiliation: Department of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church St. S.E., Minneapolis, MN, USA.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: V S
authors.initials: VS
authors.lastname: Seybold
authors.forename: H H
authors.initials: HH
authors.lastname: Loh
mesh_terms: D000818:Animals; D001345:Autoradiography; D001479:Basal Ganglia / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009714:Nucleus Accumbens / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism; D017450:Receptors, Opioid, mu / Q000235:genetics / Q000378:metabolism*
chemical_list: D017450:Receptors, Opioid, mu