Enkephalin-cell interactions.
Enkephalin analogs for multivalent ligand systems, bivalent enkephalins, multivalent enkephalins on polymers, multivalent ligands on vesicles, simultaneous activation of two different receptor systems, and cell interactions of enkephalin/polypeptide conjugates are described. Multivalent ligand systems can trigger receptor-receptor interactions and are considered to possess interesting possibilities in terms of enhanced potency, reduction of side effects, and a new biological activity.
Kimura
S
S
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Japan.
Imanishi
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000502:physiology; D002417:Cattle; D002462:Cell Membrane / Q000502:physiology*; D003911:Dextrans / Q000737:chemistry; D004745:Enkephalins / Q000138:chemical synthesis / Q000502:physiology*; D008024:Ligands; D008081:Liposomes / Q000502:physiology; D008969:Molecular Sequence Data; D011957:Receptors, Opioid / Q000502:physiology*
D003911:Dextrans; D004745:Enkephalins; D008024:Ligands; D008081:Liposomes; D011957:Receptors, Opioid