Determination of the prevalence of fibrinogen Banks peninsula mutation (gamma280Tyr-->Cys) by PCR.
A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. A novel polymerase chain reaction/restriction digestion assay for this mutation was developed and used for the screening of 300 apparently healthy European blood donors. None of these subjects carried the mutation.
Zimmermann
K
K
Baxter Hyland Immuno, Vienna, Austria.
Turecek
P L
PL
Schwarz
H P
HP
D019943:Amino Acid Substitution / Q000235:genetics*; D001317:Austria / Q000453:epidemiology; D015331:Cohort Studies; D017931:DNA Primers; D005060:Europe / Q000208:ethnology; D015241:Fibrinogens, Abnormal / Q000235:genetics*; D014644:Genetic Variation; D006579:Heterozygote; D006801:Humans; D008403:Mass Screening; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods*; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D015203:Reproducibility of Results; D044465:White People / Q000235:genetics
D017931:DNA Primers; D015241:Fibrinogens, Abnormal; C408369:fibrinogen Banks peninsula