title: Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers.
abstract: The synthesis and antihypertensive activity of racemates and enantiomers of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylates have been reported.
authors.affiliation: Laboratorio de Farmacología, Facultad de Farmacia, Universidad de Salamanca, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Martín
authors.forename: A
authors.initials: A
authors.lastname: Morán
authors.forename: M L
authors.initials: ML
authors.lastname: Martín
authors.forename: L
authors.initials: L
authors.lastname: San Román
authors.forename: P
authors.initials: P
authors.lastname: Puebla
authors.forename: M
authors.initials: M
authors.lastname: Medarde
authors.forename: E
authors.initials: E
authors.lastname: Caballero
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009543:Nifedipine / Q000493:pharmacokinetics / Q000627:therapeutic use; D010080:Oxazoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011725:Pyridines / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D010080:Oxazoles; D011725:Pyridines; D009543:Nifedipine