title: Social memory is impaired in neonatally ibotenic acid lesioned rats.
abstract: Postnatal lesion with ibotenic acid in the ventral hippocampus produces several behavioural effects that resemble the symptoms of schizophrenia. In the present study, we tested neonatally lesioned 1-year-old Sprague-Dawley rats for their social memory. It was found that social memory is worsened in lesioned rats. Subchronic treatment with haloperidol (0.025 mg/kg body weight) partly ameliorated this impairment. It was suggested that social memory might be a useful paradigm to test clinically used and potential antipsychotic drugs for their effects on learning and memory processes.
authors.affiliation: Faculty of Medicine, Otto-von-Guericke University, Institute of Pharmacology and Toxicology, Leipziger Str. 44, 39120, Magdeburg, Germany. axel.becker@medizin.uni-magdeburg.de
authors.forename: A
authors.initials: A
authors.lastname: Becker
authors.forename: G
authors.initials: G
authors.lastname: Grecksch
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001931:Brain Mapping; D004195:Disease Models, Animal; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D006801:Humans; D007051:Ibotenic Acid / Q000494:pharmacology*; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000503:physiopathology; D012919:Social Behavior
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007051:Ibotenic Acid