title: Synthesis and structure-activity relationships of a new class of selective EP3 receptor agonist, 13,14-didehydro-16-phenoxy analogues of prostaglandin E1.
abstract: A series of 13,14-didehydro-16-phenoxy analogues of prostaglandin E1 was synthesized and their agonistic activity on EP receptor subtypes was evaluated. 13,14-Didehydro-16-phenoxy-1-decarboxy analogues, 7e and 7f, display highly selective activity on the EP3 receptor subtype, thus, their utility as a selective anti-ulcer agent can be expected.
authors.affiliation: Medicinal Research Center, Taisho Pharmaceutical Co., Ltd., Ohmiya, Saitama, Japan. s14801@ccm.taisho.co.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Shimazaki
authors.forename: K
authors.initials: K
authors.lastname: Kameo
authors.forename: T
authors.initials: T
authors.lastname: Tanami
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: N
authors.initials: N
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Kiuchi
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: F
authors.initials: F
authors.lastname: Sato
authors.forename: A
authors.initials: A
authors.lastname: Ichikawa
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D015394:Molecular Structure; D018078:Receptors, Prostaglandin E / Q000819:agonists*; D058308:Receptors, Prostaglandin E, EP3 Subtype; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype; D000527:Alprostadil