Molecular remission induced by fractionated dose-escalating donor leukocyte infusion without graft-versus-host disease in a patient with chronic myelogenous leukemia relapsed after allogeneic bone marrow transplantation.
A 39-year-old male with CML who relapsed 5 years and 8 months after allogeneic bone marrow transplantation achieved complete molecular remission following fractionated dose-escalating donor leukocyte infusions. Acute or chronic graft-versus-host disease (GVHD) did not occur and the patient remained asymptomatic throughout treatment. Since no prophylaxis against GVHD was administered, this case indicated that the graft-versus-leukemia effect is entirely separate from GVHD in certain conditions.
Inai
K
K
First Department of Intemal Medicine, Fukui Medical University, School of Medicine, Japan. kinai@fmsrsa.fukui-med.ac.jp
Wano
Y
Y
Yamamoto
S
S
Ikebata
Y
Y
Iwasaki
H
H
Tsutani
H
H
Naiki
H
H
Ueda
T
T
D000328:Adult; D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000276:immunology / Q000628:therapy*; D017708:Leukocyte Transfusion; D008297:Male; D012008:Recurrence; D012074:Remission Induction; D014184:Transplantation, Homologous