Effects of clobazam and vitamin E on the lipid peroxidation in the rat brain after electroconvulsive shock.
The effect of vitamin E and clobazam on lipid peroxides [LP] in the rat brain and the pattern of electroshock-induced seizures were assessed. Significant increase in the concentration of brain LP at the peak of seizures was found. Both vitamin E and clobazam reduced the levels of LP in the rat brain after electroshock. Clobazam combined with vitamin E inhibited markedly formation of LP in the rats with electroshock-induced seizures. Vitamin E augmented anticonvulsant effect of clobazam though itself it had not exhibited any anticonvulsant effect in this model of seizures. The action of two drugs combined resulted in reducing the intensity and the duration of seizures, and only minimal seizures were observed. In our opinion the obtained results possess some interesting clinical aspect They suggest that the combined treatment with clobazam and vitamin E of epileptic patient may decrease the intensity of epileptic seizures due to inhibition of LP formation.
Sobaniec
W
W
Department of Pediatric Neurology, Medical Academy of Białystok.
Kułak
W
W
Sobaniec
H
H
Farbiszewski
R
R
Drozdowski
W
W
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects*; D000078306:Clobazam; D004565:Electroconvulsive Therapy; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D008054:Lipid Peroxides; D001569:Benzodiazepines; D014810:Vitamin E; D000078306:Clobazam