Fatty acid-depleted albumin induces the formation of echovirus A particles.
Picornavirus infection requires virus uncoating, associated with the production of 135S "A" particles and 80S empty particles from 160S mature virions, to release the RNA genome into the cell cytoplasm. Normal albumin inhibits this process. We now show that when depleted of fatty acids, albumin induces the formation of echovirus A particles.
Ward
T
T
Division of Virology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G11 5JR, United Kingdom.
Powell
R M
RM
Chaudhry
Y
Y
Meredith
J
J
Almond
J W
JW
Kraus
W
W
Nelsen-Salz
B
B
Eggers
H J
HJ
Evans
D J
DJ
D000418:Albumins / Q000737:chemistry / Q000502:physiology*; D029822:Enterovirus B, Human / Q000235:genetics / Q000502:physiology*; D005227:Fatty Acids / Q000737:chemistry*; D016679:Genome, Viral; D012367:RNA, Viral; D014771:Virion
D000418:Albumins; D005227:Fatty Acids; D012367:RNA, Viral