title: Hepatocyte growth factor/scatter factor-induced intracellular signalling.
abstract: Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in the development of a number of cellular phenotypes, including proliferation, mitogenesis, formation of branching tubules and, in the case of tumour cells, invasion and metastasis. This fascinating cytokine transduces its activities via its receptor encoded by the c-met oncogene, coupled to a number of transducers integrating the HGF/SF signal to the cytosol and the nucleus. The downstream transducers coupled to HGF/MET, most of which participate in overlapping pathways, determine the development of the cell's phenotype, which in most cell types is dual.
authors.affiliation: Laboratory of Cell Biology, Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, London, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Stuart
authors.forename: S M
authors.initials: SM
authors.lastname: Riordan
authors.forename: S
authors.initials: S
authors.lastname: Lidder
authors.forename: L
authors.initials: L
authors.lastname: Crostella
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: G G
authors.initials: GG
authors.lastname: Skouteris
mesh_terms: D000818:Animals; D017228:Hepatocyte Growth Factor / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D010641:Phenotype; D019859:Proto-Oncogene Proteins c-met / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met