DNA fragmentation in the CA2 sector of gerbil hippocampus following transient forebrain ischemia.
It has been reported that following transient forebrain ischemia in the gerbil, "delayed neuronal death" and "reactive change" occur in hippocampal CA1 and CA2 sectors, respectively. In the present study, using the gerbil transient forebrain ischemia model, we examined brain sections after various recirculation periods and demonstrated, employing the in situ nick-end labeling (TUNEL) method, a nuclear DNA fragmentation in the damaged CA2 neurons.
Iwai
T
T
Department of Neurosurgery, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu, Japan. tiwai@cc.gifu-u.ac.jp
Niwa
M
M
Hara
A
A
Mori
H
H
Uematsu
T
T
Sakai
N
N
D000818:Animals; D053938:DNA Fragmentation / Q000502:physiology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D009474:Neurons / Q000473:pathology