title: Just a little heartburn?
abstract: Lagergren et al. performed a population-based, case-control study to investigate the possible association between gastroesophageal reflux (GER) and adenocarcinoma of the esophagus and gastric cardia. They demonstrated an odds ratio of 7.7 for esophageal adenocarcinoma in patients with GER symptoms. The frequency, severity, and duration of symptoms correlated with an increased risk of esophageal adenocarcinoma. A weaker association was noted for GER and adenocarcinoma of the gastric cardia. No association surfaced between GER and squamous cell carcinoma of the esophagus.
authors.affiliation: University of Miami, School of Medicine/Mt. Sinai Medical Center, Division of Gastroenterology, Florida, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Green
authors.forename: R
authors.initials: R
authors.lastname: Amaro
authors.forename: J S
authors.initials: JS
authors.lastname: Barkin
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000453:epidemiology; D002299:Cardia; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000453:epidemiology; D006356:Heartburn / Q000209:etiology*; D006801:Humans; D012306:Risk; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D014481:United States