Usefulness of screening for congenital or acquired hemostatic abnormalities in women with previous complicated pregnancies.
Activated protein C resistance (APCR) is a common cause of familial thrombophilia and venous thrombosis. The aim of the study was to investigate the prevalence of APCR associated with factor V Leiden mutation and its relevance in comparison to other risk factors for thromboembolic disorders in women with a history of previous complicated pregnancies (history of fetal loss in the second and third trimester n = 34, preeclampsia n = 46). The frequency of APCR was significantly higher in women with a history of fetal loss and preeclampsia (23.5 and 26.1%, respectively) compared with a control group (3.8%). The prevalence of antithrombin, protein C and protein S deficiencies and the presence of antiphospholipid antibodies were also investigated: the prevalence of at least one disorder was 41.2% in the group with previous fetal loss, 37.0% in the group with previous preeclampsia and 7.5% in the control group.
Mello
G
G
Institute of Obstetrics and Gynaecology, University of Florence, Italy.
Parretti
E
E
Martini
E
E
Mecacci
F
F
La Torre
P
P
Cioni
R
R
Lucchetti
R
R
Fedi
S
S
Gori
A M
AM
Pepe
G
G
Prisco
D
D
Abbate
R
R
D020016:Activated Protein C Resistance / Q000150:complications / Q000235:genetics; D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000991:Antithrombins / Q000172:deficiency / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005165:Factor V / Q000009:adverse effects / Q000235:genetics; D005192:Family Health; D005260:Female; D005313:Fetal Death / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D006490:Hemostatics / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008403:Mass Screening; D016555:Matched-Pair Analysis; D017354:Point Mutation; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology; D011264:Pregnancy Trimesters; D015995:Prevalence; D020151:Protein C Deficiency / Q000097:blood / Q000151:congenital; D018455:Protein S Deficiency / Q000097:blood / Q000151:congenital; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000209:etiology; D044465:White People / Q000235:genetics
D017153:Antibodies, Anticardiolipin; D000991:Antithrombins; D006490:Hemostatics; D016682:Lupus Coagulation Inhibitor; C095381:factor V Leiden; D005165:Factor V