Zebrafish: a genetic approach in studying hematopoiesis.
The zebrafish (Danio rerio) has emerged in recent years as an exciting animal model system for studying vertebrate organ development and, in particular, the development of the hematopoietic system. The combined advantages of developmental biology and genetic screens for mutations in zebrafish have provided insights into early events in hematopoiesis and identified several genes required for normal blood development in vertebrates. As a result of the large-scale mutagenesis screens for developmental mutants, several zebrafish mutants with defects in blood development have been recovered. This review discusses how these blood mutations in zebrafish have given new perspectives on hematopoietic development.
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Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts, USA.
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D000818:Animals; D004195:Disease Models, Animal; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology; D009154:Mutation; D015027:Zebrafish / Q000097:blood* / Q000235:genetics*