title: Choriocarcinoma and teratoma in the ovary of a cynomolgus monkey.
abstract: An ovarian choriocarcinoma was found in a 13-year-old cynomolgus monkey (Macaca fascicularis). The tumor was accompanied by a mature teratoma in the contralateral ovary. Histologically, the choriocarcinoma was characterized by nests of cells where cytotrophoblasts occupied the periphery with syncytiotrophoblasts at the center. Immunohistochemical staining for anti-human chorionic gonadotropin was positive in the syncytiotrophoblasts. The teratoma consisted of well-differentiated epidermal cells, sebaceous glands, hair follicles, cartilage, bone, and teeth. Choriocarcinoma metastases were in multiple organs. The concomitant development of choriocarcinoma and teratoma in the ovary is a consistent finding with the human counterparts of these lesions.
authors.affiliation: Department of Toxicology, Dainippon Pharmaceutical Co., Suita, Osaka, Japan. kaoru-toyozawa@dainippon-pharm.co.jp
authors.forename: K
authors.initials: K
authors.lastname: Toyosawa
authors.forename: K
authors.initials: K
authors.lastname: Okimoto
authors.forename: T
authors.initials: T
authors.lastname: Koujitani
authors.forename: E
authors.initials: E
authors.lastname: Kikawa
mesh_terms: D000740:Anemia / Q000662:veterinary; D000818:Animals; D002822:Choriocarcinoma / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000662:veterinary*; D010051:Ovarian Neoplasms / Q000473:pathology / Q000662:veterinary*; D013724:Teratoma / Q000473:pathology / Q000662:veterinary*; D014592:Uterine Hemorrhage / Q000662:veterinary