Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers.
The synthesis and antihypertensive activity of racemates and enantiomers of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylates have been reported.
Martín
E
E
Laboratorio de Farmacología, Facultad de Farmacia, Universidad de Salamanca, Spain.
Morán
A
A
Martín
M L
ML
San Román
L
L
Puebla
P
P
Medarde
M
M
Caballero
E
E
San Feliciano
A
A
D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009543:Nifedipine / Q000493:pharmacokinetics / Q000627:therapeutic use; D010080:Oxazoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011725:Pyridines / Q000737:chemistry* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013997:Time Factors
D000959:Antihypertensive Agents; D010080:Oxazoles; D011725:Pyridines; D009543:Nifedipine