title: Efficacy of moxidectin equine oral gel against endoscopically-confirmed Gasterophilus nasalis and Gasterophilus intestinalis (Diptera: Oestridae) infections in horses.
abstract: A 3 m, video gastroscope was used to screen 47 horses suspected of being naturally infected with equine bot larvae. 17 of 47 (36.2%) candidate horses harbored Gasterophilus nasalis larvae in the proximal duodenum and 46 of 47 (97.9%) had G. intestinalis larvae in the stomach. All horses infected with G. nasalis had concurrent infections with G. intestinalis. 14 horses with dual infections were allocated randomly to two treatment groups. Seven horses in Group 1 received 2% moxidectin oral gel once at a dosage of 0.4 mg/kg bodyweight (BW), and seven horses in Group 2 were untreated controls. 14 days after treatment, all horses were necropsied and the stomach and proximal duodenum harvested from each. Bot larvae were recovered, identified to species and instar, and counted. At the label dosage, moxidectin oral gel was 100 and 97.6% effective (P < 0.05) against third-instar G. nasalis and G. intestinalis, respectively. In addition to demonstrating the boticidal efficacy of moxidectin, this trial illustrated that gastroscopy/duodenoscopy is a feasible method for confirming infections with different species of bot larvae in the horse.
authors.affiliation: East Tennessee Clinical Research, Inc., Knoxville 37922, USA. creinemey@aol.com
authors.forename: C R
authors.initials: CR
authors.lastname: Reinemeyer
authors.forename: P J
authors.initials: PJ
authors.lastname: Scholl
authors.forename: F M
authors.initials: FM
authors.lastname: Andrews
authors.forename: D W
authors.initials: DW
authors.lastname: Rock
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004064:Digestive System / Q000469:parasitology*; D004175:Diptera; D004386:Duodenum / Q000469:parasitology; D005773:Gastroscopy / Q000662:veterinary; D005782:Gels; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology; D006736:Horses; D007306:Insecticides / Q000008:administration & dosage; D018942:Macrolides; D010273:Parasitic Diseases, Animal / Q000188:drug therapy*; D011897:Random Allocation; D013270:Stomach / Q000469:parasitology
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D007306:Insecticides; D018942:Macrolides; C027837:moxidectin