Cholesterol in signal transduction.
Membrane cholesterol impinges on signal transduction in several ways, which is highlighted in particular by the Hedgehog signaling pathway. In Hedgehog signaling, cholesterol is important for ligand biogenesis, as well as for signal transduction in receiving cells. Hedgehog ligands are post-translationally modified by cholesterol, and the Hedgehog receptor, Patched, is structurally similar to the Niemann-Pick C1 protein, which functions in intracellular lipid transport. Although the exact role of cholesterol in Hedgehog signal transduction remains elusive and is probably multifaceted, studies over the past year have implicated raft membrane subdomains, cholesterol transport and a link between protein and lipid trafficking in endocytic compartments.
Incardona
J P
JP
Department of Biological Structure and Center for Developmental Biology, University of Washington, Seattle 98195, USA. jincar@u. washington.edu
Eaton
S
S
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins; D051242:Caveolin 1; D022461:Caveolins; D002784:Cholesterol / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology; D006028:Glycosphingolipids / Q000378:metabolism; D053823:Hedgehog Proteins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D050356:Lipid Metabolism; D008562:Membrane Glycoproteins; D008565:Membrane Proteins / Q000378:metabolism; D000077296:Niemann-Pick C1 Protein; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators
D002352:Carrier Proteins; D051242:Caveolin 1; D022461:Caveolins; D006028:Glycosphingolipids; D053823:Hedgehog Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C106881:NPC1 protein, human; D000077296:Niemann-Pick C1 Protein; D011506:Proteins; D015534:Trans-Activators; D002784:Cholesterol