title: Oxidative stress in alcoholic liver disease.
abstract: We report on the prooxidant (lipid peroxides) and antioxidant levels (ascorbic acid, reduced glutathione, superoxide dismutate activity) in healthy individuals (30) and patients with cirrhosis (37; 22 alcoholic cirrhosis and 15 non alcoholic cirrhosis). A significant increase in plasma lipid peroxide (P < 0.05) and ascorbic acid (P < 0.01) and a significant decrease in reduced glutathione (P < 0.001) and superoxide dismutase activity (P < 0.05) in haemolysate was observed in cirrhosis patients compared to the control group. A significant decrease in reduced glutathione (P < 0.01) and superoxide dismutase (P < 0.05) activity was also observed when the alcoholic cirrhosis group was compared to non alcoholic group. A significant increase in aspartate transaminase (P < 0.05), gamma glutamyl transaminase (P < 0.01) and aspartate transaminase/alanine transaminase (P < 0.05) ratio was seen in alcoholic cirrhosis group. A significant positive correlation between gamma glutamyl transferase and lipid peroxides (r = 0.48, P < 0.05) was observed in alcoholic cirrhosis.
authors.affiliation: Department of Biochemistry, Sri Ramachandra Medical College & Research Institute, Chennai.
authors.forename: G
authors.initials: G
authors.lastname: Nalini
authors.forename: C
authors.initials: C
authors.lastname: Hariprasad
authors.forename: V A
authors.initials: VA
authors.lastname: Narayanan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001205:Ascorbic Acid / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008104:Liver Cirrhosis, Alcoholic / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: D008054:Lipid Peroxides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001205:Ascorbic Acid