[The artificial lymph node].
Adsorption of lymphocytes on the sorbents in correction of inflammatory lesions has significant clinical perspectives as the cells and active biological substances they secrete function actively in inflamed tissues acting in the site of its application: every cell adsorbs and inactivates foreign substances, every cytokin affects certain target cells. The products of these cells functioning and dissociation as well as the products of immune system reaction to them remain on the sorbent and are eliminated together with granules during bandaging or by the end of the treatment thus do not entering the organism. Lymphocytic monolayer on the sorbent does not prevent its specific action in pathologic nidus. In this case sorbent does not only drain the tissue duplicating certain primitive non specific functions of regional lymph node (barrier, filtrating, transport, draining and protective functions) but also performs certain highly specialized functions of immunocompetent organs--selective adsorption and inactivation of antigenic substances. It is reasonable to use sorbents for adsorbing lymphocytes in kapron containers which exclude the preparation leak into wounds and cavities and act as a filter preventing fast inactivation of the preparation by large fragments of tissue detritus.
Borodin
Iu I
IuI
Institute of Clinical and Experimental Lymphology, Siberian Section, Russian Academy of Medical Sciences, Novosibirsk.
Liubarskiĭ
M S
MS
Maĭborodin
I V
IV
Pekarev
O G
OG
Smagin
A A
AA
D000818:Animals; D002209:Caprolactam; D002448:Cell Adhesion; D008198:Lymph Nodes / Q000166:cytology / Q000502:physiology*; D008214:Lymphocytes / Q000166:cytology / Q000502:physiology; D008855:Microscopy, Electron, Scanning; D016060:Sorption Detoxification / Q000295:instrumentation* / Q000379:methods; D013154:Spleen / Q000166:cytology; D013499:Surface Properties; D013552:Swine; D013997:Time Factors
D002209:Caprolactam; C000362:capron