[The morphological validation for the clinical use of a nerve transplantation method].
The paper summarizes the results of long-term studies made by the Department of Morphology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, and the data available in the literature on the problems of neurografting and histogenesis of nervous tissue in the human prenatal development. It presents data on the conditions that most favourably affect the acceptance and development of neurografts, the integration of their cell elements with the recipient's brain, and the correction of dysfunctions. Emphasis is laid on the choice of a donor's material, the modes of its treatment and insertion, on the determination of grafting sites and scope, on immunosuppression and postoperative drug provision.
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D001921:Brain / Q000276:immunology / Q000473:pathology / Q000601:surgery; D016380:Brain Tissue Transplantation / Q000276:immunology / Q000379:methods / Q000473:pathology; D016332:Fetal Tissue Transplantation / Q000276:immunology / Q000379:methods / Q000473:pathology; D005865:Gestational Age; D006085:Graft Survival; D006801:Humans; D009417:Nerve Tissue / Q000196:embryology / Q000637:transplantation*; D009474:Neurons / Q000637:transplantation; D014019:Tissue Donors