An efficient one-pot method for the large-quantitative production of radiopharmaceutical ligand: diazadioximes.
An efficient one-pot procedure for the preparation of diazadioxime was described. Treatment of ketooximes with alkyldiamine followed by NaBH4 in dry ethanol afforded the corresponding d,l-diazadioximes in 56--74% yield without isolation of the intermediates.
Ding
H J
HJ
Department of Nuclear Medicine, School of Technology for Medical Sciences, Kaohsiung Medical University, Taiwan, R.O.C.
Huang
Y F
YF
Tzeng
C C
CC
Yeh
S J
SJ
Wei
L L
LL
D003959:Diamines / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D010091:Oximes / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
D003959:Diamines; D007202:Indicators and Reagents; D008024:Ligands; D010091:Oximes; D019275:Radiopharmaceuticals