[Activity of the genome of cardiomyocytes as an indicator of the development of adaptive changes in the myocardium following exposure of the central nervous system to electromagnetic fields].
Methods of cardiomyocyte nuclei isolation from the myocard homogeneous mixture, and of cardiomyocyte genome activity estimation were elaborated. In the experiments with hyperlipoproteidemic rats, cardiomyocyte genome activity was shown to reflect the primary adaptive changes in the myocard, and to serve a reliable index of their influence on the CNS regulatory centres exposed to electromagnetic field, which is used for hyperlipoproteidemia treatment. The cardiomyocyte genome activity was used to distinguish between three types of development of adaptive reactions in the myocard.
Zubkova
S M
SM
Russian Scientific Centre of Rehabilitating Medicine and Health Resort Cure, Moscow.
Mikhaĭlik
L V
LV
Varakina
N I
NI
Strukova
E V
EV
Bobkova
A S
AS
D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology / Q000528:radiation effects*; D004574:Electromagnetic Fields; D016678:Genome; D006321:Heart / Q000503:physiopathology*; D006951:Hyperlipoproteinemias / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy; D008297:Male; D009206:Myocardium / Q000473:pathology*; D051381:Rats