Selective estrogen receptor modulators (SERMs): effects on multiple organ systems.
SERMs represent a structurally diverse group of compounds which interact with the estrogen receptor but which elicit agonist or antagonist activity depending on the organ system and physiological context. Evaluation of the actions of these compounds has led researchers to a fuller understanding not only of the antiestrogens but also of steroid signaling in general. Based on their evolving clinical profiles, SERMs have the potential to address long-term health maintenance needs of women in their non-reproductive years.
Agnusdei
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European Medical Coordinator, Skeletal Diseases, Eli Lilly & Co., Florence, Italy. agnusdei_donato@lilly.com
Iori
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D000818:Animals; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology* / Q000627:therapeutic use
D020845:Selective Estrogen Receptor Modulators