Dysregulation of the protein tyrosine kinase LCK in lymphoproliferative disorders and in other neoplasias.
Initially identified as a T-cell specific member of the Src family of protein tyrosine kinases, Lck has become the object of intensive investigations which have revealed a key role for this kinase in the central processes controlling T-cell development, activation, proliferation and survival. Experimental evidence of the oncogenic potential of Lck, together with the identification of defects in the regulation of Lck expression or activity in T-cell leukemias, suggests that dysregulation of Lck might play a role in neoplastic transformation. Here we review the data documenting a potential role for this kinase in the initiation and maintenance of the transformed state in human cancers.
Majolini
M B
MB
Department of Evolutionary Biology, University of Siena, Italy.
Boncristiano
M
M
Baldari
C T
CT
D002471:Cell Transformation, Neoplastic; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000502:physiology*; D008232:Lymphoproliferative Disorders / Q000201:enzymology* / Q000235:genetics; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics
D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)