title: An evaluation of mattress encasings and high efficiency particulate filters on asthma control in the tropics.
abstract: The effect of two allergen avoidance modalities, Allergy Control Covers (ACC) and High Efficiency Particulate Filters (HEPA) on asthma control in children were evaluated. This was an open study involving 24 dust mite sensitive asthmatic children. Following a 4 week run-in period, the subjects were randomly allocated to use mattresses fitted with ACC (n = 6), HEPA filters in their bedrooms (n = 12) or act as controls (n = 6) for a study duration of 4 months. Measurements of the major Dermatophagoides spp. mite allergens, Der p 1 and Der f 1, levels in dust samples obtained from mattresses were made at baseline, 1, 2 and 4 months post implementation. Daily symptom scores including morning and evening peak flow readings, and monthly spirometry and exercise bronchoprovocation tests were carried out Our results showed that dust mite allergen levels in mattresses fell at 1 and 2 months post implementation in the ACC group (p<0.05). In contrast, no decrease in allergen levels was seen in the HEPA and control group. At the end of the 16 weeks, only the ACC group showed improvement in FEV1 and reduction in diurnal peak expiratory flow rate (p<0.05). Improvement in mean symptom scores was also observed for both the ACC and HEPA groups, but not the control groups (p<0.05). Although the numbers in this study were small, the results Indicate that the effectiveness on mite exposure barrier covers was short-lived, and the improvement in asthma control though documented was not obvious.
authors.affiliation: Department of Paediatrics, National University of Singapore, Singapore.
authors.forename: D G
authors.initials: DG
authors.lastname: Thiam
authors.forename: C F
authors.initials: CF
authors.lastname: Tim
authors.forename: L S
authors.initials: LS
authors.lastname: Hoon
authors.forename: Z
authors.initials: Z
authors.lastname: Lei
authors.forename: L
authors.initials: L
authors.lastname: Bee-Wah
mesh_terms: D000293:Adolescent; D039741:Antigens, Dermatophagoides; D001249:Asthma / Q000517:prevention & control*; D001513:Beds; D002648:Child; D004391:Dust / Q000032:analysis; D005260:Female; D005374:Filtration / Q000295:instrumentation*; D006023:Glycoproteins / Q000032:analysis; D006798:Housing; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests; D014329:Tropical Climate
chemical_list: D039741:Antigens, Dermatophagoides; D004391:Dust; D006023:Glycoproteins