Using fMRI to study recovery from acquired dysphasia.
We have used functional magnetic resonance imaging (fMRI) to characterize brain activations associated with two distinct language tasks performed by a 28-year-old woman after partial recovery from dysphasia due to a left frontal hemispheric ischemic stroke. MRI showed that her ischemic lesion extended posteriorly from the left inferior frontal to the perisylvian cortex. fMRI scans of both language tasks revealed substantial differences in activation pattern relative to controls. The nature of this difference was task-specific. During performance of a verbal semantic decision task, the patient, in contrast to controls, activated a network of brain areas that excluded the inferior frontal gyrus (in either hemisphere). A second task involving rhyme judgment was designed to place a heavier cognitive load on language production processes and activated the left inferior frontal gyrus (Broca's area) strongly in normal controls. During this task, the most prominent frontal activation in the patient occurred in the right homologue of Broca's area. Subsequent analysis of this data by methods able to deal with responses of changing amplitude revealed additional, less sustained recruitment by the patient of cortex adjacent to the infarct in the region inferior to Broca's area during rhyming. These results suggest that in addition to changes in cognitive strategy, recovery from dysphasia could be mediated by both the preservation of neuronal networks in and around the infarct and the use of homologous regions in the contralateral hemisphere.
Calvert
G A
GA
Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), John Radcliffe Hospital, Headington, Oxford, OX3 9DU. gemma@fmrib.ox.ac.uk
Brammer
M J
MJ
Morris
R G
RG
Williams
S C
SC
King
N
N
Matthews
P M
PM
D000328:Adult; D001039:Aphasia, Broca / Q000175:diagnosis* / Q000209:etiology / Q000534:rehabilitation*; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D015600:Glasgow Coma Scale; D006801:Humans; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D020127:Recovery of Function; D013997:Time Factors