title: Multiple 'serrated adenocarcinomas' of the colon with a cell lineage common to metaplastic polyp and serrated adenoma. Case report of a new subtype of colonic adenocarcinoma with gastric differentiation.
abstract: A 70-year-old woman underwent right hemicolectomy and six carcinomas were recognized in the resected colon. These carcinomas were considered to be of a cell lineage common to serrated adenoma (SA) and hyperplastic (metaplastic) polyp (H/MP), because of the occurrence of multiple SAs and H/MPs around the carcinomas, as well as the co-existence of SA and H/MP areas within the carcinomas. These carcinomas had the following common histological and immunohistochemical features: a serrated structure resembling SA; a lace-like structure; infiltrative growth within the muscularis propria, with dedifferentiation at the invasive front; and immunohistochemical expression of pS2 and human gastric mucin. Based on these features, a new subtype of carcinoma is proposed, with a cell lineage common to SA and H/MP. It would also seem that p53 is involved in the serrated adenoma-carcinoma sequence.
authors.affiliation: Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yao
authors.forename: K i
authors.initials: Ki
authors.lastname: Nishiyama
authors.forename: M
authors.initials: M
authors.lastname: Oya
authors.forename: T
authors.initials: T
authors.lastname: Kouzuki
authors.forename: M
authors.initials: M
authors.lastname: Kajiwara
authors.forename: M
authors.initials: M
authors.lastname: Tsuneyoshi
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D019070:Cell Lineage; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007417:Intestinal Polyps / Q000737:chemistry / Q000473:pathology*; D009077:Mucins / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology*
chemical_list: D009077:Mucins; D009363:Neoplasm Proteins