Gastric-Mucocutaneous gammadelta T cell lymphoma: possible association with Epstein-Barr virus?
Gammadelta T cell lymphoma is usually either subcutaneous or hepato-splenic and involvement of other extranodal sites is rare. Here we report an unusual case of gammadelta T cell lymphoma involving the subcutaneous tissue, vocal cords, gastric mucosa and the central nervous system with a rapidly progressive clinical course and fatal outcome. Epstein-Barr virus (EBV) was shown to be present in the tumor cells, and is thought to play a role in the pathophysiology of this particular case of lymphoma.
Shapira
M Y
MY
Division of Medicine, Hadassah University Hospital, Hebrew University--Hadassah Medical School, Jerusalem, Israel. shapiram@hadassah.org.il
Caspi
O
O
Amir
G
G
Zlotogorski
A
A
Naparstek
Y
Y
D000328:Adult; D004817:Epidermis / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007820:Laryngeal Mucosa / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000821:virology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology / Q000821:virology
D016692:Receptors, Antigen, T-Cell, gamma-delta