Is adrenomedullin a causal agent in some cases of type 2 diabetes?
The study of two populations with a recent onset of type 2 diabetes showed that a subset of the patients had higher levels of adrenomedullin (AM) than the rest of the diabetics. In this subset, physiological elevations of AM might have triggered the disease in predisposed individuals. Diabetics showed higher levels of AM than healthy controls. In addition, glycemia was measured in diabetic rats after injection of saline, AM, or antiAM antibody. AM elevated glycemia, whereas the antibody reduced circulating glucose to normal. These results suggest that manipulation of AM levels could represent a new approach in the management of diabetes for the appropriate individuals.
Martínez
A
A
Department of Cell and Cancer Biology, National Cancer Institute, Medicine Branch, Division of Clinical Sciences, National Institutes of Health, Bethesda, MD 20892, USA. martineza@bprb.nci.nih.gov
Elsasser
T H
TH
Bhathena
S J
SJ
Pío
R
R
Buchanan
T A
TA
Macri
C J
CJ
Cuttitta
F
F
D000293:Adolescent; D053607:Adrenomedullin; D000328:Adult; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000209:etiology* / Q000235:genetics; D016640:Diabetes, Gestational / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000502:physiology*; D010641:Phenotype; D011236:Prediabetic State / Q000097:blood / Q000209:etiology; D011247:Pregnancy; D051381:Rats; D011918:Rats, Inbred SHR
D000906:Antibodies; D001786:Blood Glucose; D010455:Peptides; D053607:Adrenomedullin