Synthesis and analgesic activity of N-(N-acetyl-L-amino-acyl)-5-methoxytryptamines.
5-Methoxytryptamine was acylated with N-acetyl-L-amino acids to give rise the corresponding N-(N-acetyl-L-amino acyl)-5-methoxytryptamines. The analgesic activity was evaluated by the tail flick test. Among the 6 compounds, the analgesic potency of N-(N-acetyl-tryptophanyl)-5-methoxytryptamine (5e) and N-(N-acetyl-glycyl)-5-methoxytryptamine (5a) are much more potent than that of melatonin.
Dongmei
H
H
College of Pharmaceutical Sciences, Beijing Medical University, PR China.
Chao
W
W
Ming
Z
Z
Shiqi
P
P
D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D008297:Male; D008550:Melatonin / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D017288:Pain Threshold / Q000187:drug effects; D014363:Tryptamines / Q000138:chemical synthesis* / Q000737:chemistry
D000700:Analgesics; D014363:Tryptamines; D008550:Melatonin