title: [Heparin-induced thrombocytopenia and hemofiltration: regional anticoagulation with sodium citrate].
abstract: The symptoms, diagnosis, and therapy for a septic patient with acute renal failure on continuous hemofiltration and heparin-anticoagulation who developed heparin-induced thrombocytopenia type II are described. Different alternatives for anticoagulation of extracorporal circulation are discussed. The principles of anticoagulation with sodium citrate are presented. It is necessary to closely monitor and, if need be, correct the serum calcium levels and acid base metabolism. We show that regional anticoagulation with sodium citrate is an effective and safe treatment.
authors.affiliation: Klinik für Anästhesiologie und Intensivtherapie, Städtisches Krankenhaus Dresden-Friedrichstadt.
authors.forename: T
authors.initials: T
authors.lastname: Künstle
authors.forename: S
authors.initials: S
authors.lastname: Maulhardt
authors.forename: M
authors.initials: M
authors.lastname: Grünberger
authors.forename: K F
authors.initials: KF
authors.lastname: Rothe
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use*; D019343:Citric Acid / Q000627:therapeutic use*; D005112:Extracorporeal Circulation; D006440:Hemofiltration / Q000009:adverse effects*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000925:Anticoagulants; D019343:Citric Acid; D006493:Heparin