Immunohistochemical localization of some extracellular molecules and their integrin receptors in the rat Pacinian corpuscles.
The present results suggest that laminin-1 and 3 are localized in the specialized Schwann cells of Pacinian corpuscles, in spite of incomplete deposition of the basal lamina on the surface of their cytoplasmic processes. In addition, laminin-3 is concentrated and probably function as a stop protein not only in the neuromuscular junction, but also in the specialized Schwann cells enveloping the dendritic zone of the afferent axon. No significant changes of immunostaining for both laminins and their integrin receptors following denervation of Pacinian corpuscles indicate that their synthesis is independent to afferent axon as a prerequisite for successful reinnervation.
Dubový
P
P
Department of Anatomy, Medical Faculty, Brno, Czech Republic.
Svízenská
I
I
Jancálek
R
R
Klusáková
I
I
D000818:Animals; D003714:Denervation; D005260:Female; D007150:Immunohistochemistry; D016023:Integrins / Q000378:metabolism*; D007797:Laminin / Q000378:metabolism*; D008297:Male; D010141:Pacinian Corpuscles / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012583:Schwann Cells / Q000276:immunology / Q000378:metabolism
D016023:Integrins; D007797:Laminin; C121346:laminin 1