title: Accuracy of normal-dose contrast-enhanced MR angiography in assessing renal artery stenosis and accessory renal arteries.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the accuracy of breath-hold contrast-enhanced MR angiography in the assessment of renal artery stenosis and accessory renal arteries using a standard dose of gadolinium.
  
  
  METHODS
  Thirty-eight patients suspected of having renal artery stenosis underwent MR angiography and intraarterial digital subtraction angiography, which was the method of reference. Three-dimensional gradient-echo MR subtraction angiography (TR/TE, 5.8/1.8 msec) was performed on a 1.5-T imager using a phased array body coil. Before imaging, a separate timing bolus sequence was used, administering 1.0 ml of contrast agent. Gadopentetate dimeglumine (15 ml) was injected using an MR power injector. Two observers, who were unaware of each other's interpretation and of MR findings, assessed digital subtraction angiography. Likewise, two other observers assessed MR angiography.
  
  
  RESULTS
  Digital subtraction angiography depicted 75 main and 17 accessory renal arteries (n = 92). All main renal arteries and 13 accessory renal arteries were identified on MR angiography. Compared with digital subtraction angiography, MR imaging correctly classified 57 of 66 arteries without a hemodynamically significant stenosis (0-49%), 22 of 22 arteries as significantly stenotic (50-99%), and four of four occluded arteries; five stenoses were overestimated. There was one false-positive finding of an accessory renal artery on MR angiography that was identified retrospectively on digital subtraction angiography. Interobserver agreement was high. Sensitivity and specificity for grading significant stenosis were 100% and 85%, respectively.
  
  
  CONCLUSIONS
  Contrast-enhanced MR angiography, using +/-0.1 mmol/kg of gadolinium, is an accurate method in the assessment of renal artery stenosis and accessory renal arteries.
authors.affiliation: Department of Radiology, University Hospital, Nijmegen, The Netherlands.
authors.forename: M B
authors.initials: MB
authors.lastname: Korst
authors.forename: F B
authors.initials: FB
authors.lastname: Joosten
authors.forename: C T
authors.initials: CT
authors.lastname: Postma
authors.forename: G J
authors.initials: GJ
authors.lastname: Jager
authors.forename: J K
authors.initials: JK
authors.lastname: Krabbe
authors.forename: J O
authors.initials: JO
authors.lastname: Barentsz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012077:Renal Artery / Q000002:abnormalities* / Q000473:pathology; D012078:Renal Artery Obstruction / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA