title: Retinopathy in a patient with thrombotic thrombocytopenic purpura complicated by polymyositis.
abstract: BACKGROUND
  Cotton wool spots are known to be a complication in patients with thrombotic thrombocytopenic purpura or with polymyositis.
  
  
  METHODS
  A 53-year-old woman developed numerous cotton wool spots around the optic disc of both eyes.
  
  
  METHODS
  Fluorescein angiography disclosed capillary obstruction and microaneurysms in the early phase, followed by dye leakage in the late phase. Systemically, she showed fever, hemolytic anemia, fragmented red blood cells, thrombocytopenia, proximal muscle weakness, and elevation of serum muscle enzymes. This led to a diagnosis of thrombotic thrombocytopenic purpura complicated by polymyositis.
  
  
  CONCLUSIONS
  We believe that this is the first case of thrombotic thrombocytopenic purpura complicated by polymyositis to develop cotton wool spots.
authors.affiliation: Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsuo
authors.forename: S
authors.initials: S
authors.lastname: Matsuura
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008875:Middle Aged; D017285:Polymyositis / Q000150:complications*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications*; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology