title: Identification of chick frizzled-10 expressed in the developing limb and the central nervous system.
abstract: We have identified chick frizzled (Fz)-10, encoding a Wnt receptor, and examined the expression pattern during embryogenesis. Fz-10 is expressed in the region posterior to the Hensen's node at stage 6. Fz-10 expression is detected in the dorsal domain of the neural tube and the central nervous system of the developing embryo. In the developing limb, Fz-10 expression starts at stage 18 in the posterior-dorsal region of the distal mesenchyme, and gradually expands to the anterior-distal region. Fz-10 is also expressed in the feather bud and branchial arch. Implantation of Sonic hedgehog (Shh)-expressing cells into the anterior margin of the limb bud resulted in the induction of Fz-10 expression in anterior-dorsal mesenchyme.
authors.affiliation: Department of Molecular Biology, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawakami
authors.forename: N
authors.initials: N
authors.lastname: Wada
authors.forename: S
authors.initials: S
authors.lastname: Nishimatsu
authors.forename: C
authors.initials: C
authors.lastname: Komaguchi
authors.forename: S
authors.initials: S
authors.lastname: Noji
authors.forename: T
authors.initials: T
authors.lastname: Nohno
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins; D001483:Base Sequence; D002490:Central Nervous System / Q000196:embryology*; D002642:Chick Embryo; D018076:DNA, Complementary; D051157:Frizzled Receptors; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D018878:Limb Buds / Q000196:embryology; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics; D015534:Trans-Activators
chemical_list: D030161:Avian Proteins; D018076:DNA, Complementary; C492383:FZD10 protein, Gallus gallus; D051157:Frizzled Receptors; D053823:Hedgehog Proteins; D011506:Proteins; D011956:Receptors, Cell Surface; D015534:Trans-Activators