Superficial gastric carcinoma developed on localized hypertrophic lymphocytic gastritis: a variant of localized Ménétrier's disease?
Ménétrier's disease is a rare premalignant condition that usually involves the entire stomach. Only few cases of localized disease have been reported, rarely with cancer. Lymphocytic gastritis is a newly described entity that may share a common pathogenesis with Ménétrier's disease. The authors report the case of a 62 year old woman with known liver cirrhosis in whom endoscopic examination of the stomach showed an antral tumor. Examination of the surgical specimen showed a superficial gastric adenocarcinoma developed on an hypertrophic gastropathy with both Ménétrier's disease and lymphocytic gastritis features. This observation strengthens the hypothesis of a common mechanism between Ménétrier's disease and lymphocytic gastritis, which may be part of the same disease spectrum. This disease could also correspond to the "hypertrophic lymphocytic gastritis" recently described.
Charton-Bain
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Service d'Anatomie Pathologique, Hôpital Broussais, Paris, France.
Paraf
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Bruneval
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D000230:Adenocarcinoma / Q000209:etiology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005758:Gastritis, Hypertrophic / Q000150:complications / Q000473:pathology*; D006801:Humans; D008218:Lymphocytosis / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000209:etiology / Q000473:pathology*