title: Influence of spin probe structure on its distribution in SLN dispersions.
abstract: Solid lipid nanoparticles (SLN) are drug carrier system composed of biodegradable substances, which are solid at room temperature. The physico-chemical properties and structure of the incorporated compounds can affect their partitioning in SLN dispersions. In this work the influence of lipophilicity and structure of different SP on its location in SLN were studied. By electron paramagnetic resonance (EPR) measurements it was found that lipophilic SP distribute between a solid glyceride core and a soft phospholipid layer, with the more polar part (piperidine ring or methylcarboxylic groups) oriented toward the water-lipid interface. The majority of SP is located in the phospholipid layer, but the portion in the solid lipid core increases with SP lipophilicity. The hydrophilic Tempol does not incorporate into SLN.
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia.
authors.forename: P
authors.initials: P
authors.lastname: Ahlin
authors.forename: J
authors.initials: J
authors.lastname: Kristl
authors.forename: M
authors.initials: M
authors.lastname: Sentjurc
authors.forename: J
authors.initials: J
authors.lastname: Strancar
authors.forename: S
authors.initials: S
authors.lastname: Pecar
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D004578:Electron Spin Resonance Spectroscopy; D008055:Lipids / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D020442:Poloxamer / Q000737:chemistry; D013025:Glycine max; D013113:Spin Labels; D014280:Triglycerides / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D008055:Lipids; D010713:Phosphatidylcholines; D013113:Spin Labels; D014280:Triglycerides; D020442:Poloxamer; C005859:tripalmitin