title: Morphogenetic cell movement in Dictyostelium.
abstract: Dictyostelium morphogenesis starts with the chemotactic aggregation of starving individual cells. The cells move in response to propagating waves of the chemoattractant cyclic AMP initiated by cells in the aggregation centre. During aggregation the cells begin to differentiate into several types with different signalling and chemotactic properties. These cell types sort out from each other to form an axial pattern in the slug. There is now good evidence that periodic chemotactic signals not only control aggregation, but also later stages of morphogenesis. These signals take the form of target patterns, spirals, multi-armed spirals and scroll waves. I will discuss their role in the control of cell movement during mound and slug formation and in the formation of the fruiting body.
authors.affiliation: Department of Anatomy and Physiology, WTB/MSI Complex, University of Dundee, Dundee, DD1 5EH, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Weijer
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004023:Dictyostelium / Q000166:cytology* / Q000502:physiology*; D009024:Morphogenesis