title: Primary and adjuvant therapy, prognostic factors and survival in 1053 breast cancers diagnosed in a trial of mammography screening.
abstract: BACKGROUND
  As mammographic screening becomes more widespread, larger numbers of tumours are diagnosed while small and node negative.
  
  
  METHODS
  We examined detection mode, tumour size, node status, histological type, therapy and outcome in 1053 breast cancers diagnosed in one county of the Swedish Two-County Trial of mammographic screening for breast cancer.
  
  
  RESULTS
  Of patients undergoing total mastectomy with axillary dissection, 65% were found to be node negative. For tumours of size 1-9 mm, 95% were node negative. The major effects on survival were tumour size, node status and histological type. Primary adjuvant therapy had no significant association with survival.
  
  
  CONCLUSIONS
  The advent of mammography has substantially enhanced the possibilities for less radical treatment. There is an urgent need for therapeutic trials utilizing mammographic-pathological correlations to ascertain in advance which tumours can and which cannot benefit from more radical therapy.
authors.affiliation: Mammography Department, Central Hospital, Falun, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Tabar
authors.forename: H H
authors.initials: HH
authors.lastname: Chen
authors.forename: S W
authors.initials: SW
authors.lastname: Duffy
authors.forename: U B
authors.initials: UB
authors.lastname: Krusemo
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000628:therapy; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008327:Mammography; D008403:Mass Screening; D008408:Mastectomy / Q000401:mortality*; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis