Purification and bioassays of a diuretic and natriuretic fraction from garlic (Allium sativum).
The intravenous administration of a purified fraction (6 microg/kg) to anaesthesized dogs was followed by a significant biphasic diuretic and natriuretic response which reached a maximum at 180 min after injection. Chloride, but not potassium ions, followed the natriuretic profile. No changes were observed in arterial blood pressure or in the electrocardiogram. The purified garlic fraction also induced an inhibitory dose-dependent effect on kidney Na, K-ATPase.
Pantoja
C V
CV
Departamento de Fisiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Casilla 160-C., Concepción, Chile.
Martín
N T
NT
Norris
B C
BC
Contreras
C M
CM
D000490:Allium / Q000737:chemistry*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D004231:Diuresis / Q000187:drug effects; D004232:Diuretics / Q000302:isolation & purification* / Q000494:pharmacology*; D004285:Dogs; D004573:Electrolytes / Q000652:urine; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014563:Urodynamics / Q000187:drug effects
D004232:Diuretics; D004573:Electrolytes; D011506:Proteins; D000254:Sodium-Potassium-Exchanging ATPase