The highly protective effect of newborn circumcision against invasive penile cancer.
OBJECTIVE
We determined the relation between newborn circumcision and both invasive penile cancer (IPC) and carcinoma in situ (CIS) among adult male members of a large health maintenance organization.


METHODS
Circumcision status was ascertained by a combination of pathology reports, medical record review, and questionnaires for 213 adult male members of a large prepaid health plan who were diagnosed with IPC or CIS.


RESULTS
Of 89 men with IPC whose circumcision status was known, 2 (2.3%) had been circumcised as newborns, and 87 were not circumcised. Of 118 men with CIS whose circumcision status was known, 16 (15.7%) had been circumcised as newborns.


CONCLUSIONS
Our results confirm the highly protective effect of newborn circumcision against IPC and the less protective effect against CIS.
Schoen
E J
EJ
Department of Genetics, Pediatrics, Kaiser Permanente Medical Center, Oakland, California 94611-5693, USA. edgar.schoen@ncal.kaiperm.org
Oehrli
M
M
Colby
C d
Cd
Machin
G
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D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002140:California; D002277:Carcinoma / Q000473:pathology / Q000517:prevention & control*; D002278:Carcinoma in Situ / Q000517:prevention & control; D002944:Circumcision, Male; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010412:Penile Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology