title: A pilot study evaluating the treatment of postparotidectomy sialoceles with botulinum toxin type A.
abstract: OBJECTIVE
  To report our experience in treating 4 cases of recurrent siacloceles with botulinum toxin type A after partoid surgery.
  
  
  METHODS
  This is a prospective, nonrandomized, nonblinded pilot study describing a new use for botulinum toxin type A.
  
  
  METHODS
  Tertiary academic medical center.
  
  
  METHODS
  Four patients (2 men and 2 women) with persistent postparotidectomy sialoceles who had undergone various treatment failures were included. The diagnosis was made by fine-needle aspiration of the mass based on well-recognized cytologic features of the entity, as well as an elevated amylase level and no evidence of tumor or infection.
  
  
  METHODS
  Sialoceles were aspirated before local injection of botulinum toxin type A (30-50 U) subcutaneously.
  
  
  METHODS
  The patients were followed up 1 week after receiving botulinum toxin type A injection and then at monthly intervals. They were extensively questioned and examined for any evidence of side effects or recurrence.
  
  
  RESULTS
  All patients had total resolution of sialocele or external salivary fistula within 1 month of treatment. None of the patients to date have demonstrated recurrences at 7 through 13 months, and there were no complications, particularly facial nerve weakness.
  
  
  CONCLUSIONS
  Our findings suggested that botulinum toxin type A offers a highly effective, safe, and noninvasive method of treatment in postparotidectomy sialocele.
authors.affiliation: Division of Otolaryngology--Head and Neck Surgery, Department of Surgery, Albany Medical College, NY 12208, USA.
authors.forename: H
authors.initials: H
authors.lastname: Vargas
authors.forename: L T
authors.initials: LT
authors.lastname: Galati
authors.forename: S M
authors.initials: SM
authors.lastname: Parnes
mesh_terms: D000328:Adult; D000368:Aged; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D003560:Cysts / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000601:surgery*; D010307:Parotid Neoplasms / Q000601:surgery*; D010865:Pilot Projects; D011183:Postoperative Complications / Q000188:drug therapy*; D011446:Prospective Studies; D012008:Recurrence; D012463:Saliva; D013396:Suction; D016896:Treatment Outcome
chemical_list: D019274:Botulinum Toxins, Type A