High frequency of loss of heterozygosity for 1p35-p36 (D1S247) in Wilms tumor.
We analyzed the loss of heterozygosity (LOH) for 1p in 18 Wilms tumors using a panel of 11 polymorphic markers. Loss of heterozygosity was identified in 56% of the tumors. The smallest region of overlap was defined for marker D1S247, underlying the 1p35-1p36.1 locus. This is the highest LOH frequency for 1p, or for the well-defined 11p13 and 11p15.5 loci. Based on the fact that tumors of all stages, with both favorable and unfavorable histology, exhibited LOH, we suggest that the 1p35-1p36.1 locus is involved in the etiology of Wilms tumor.
Steinberg
R
R
Department of Pediatric Surgery, Tel Aviv, Israel.
Freud
E
E
Zer
M
M
Ziperman
I
I
Goshen
Y
Y
Ash
S
S
Stein
J
J
Zaizov
R
R
Avigad
S
S
D002648:Child; D002675:Child, Preschool; D002878:Chromosomes, Human, Pair 1; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009367:Neoplasm Staging; D009396:Wilms Tumor / Q000235:genetics* / Q000473:pathology