title: [Genetic diagnosis and cardiovascular diseases].
abstract: Many of cardiovascular diseases are multifactorial and both environmental and genetic factors are associated with their onset and/or progression. Recently, the development of genetic analysis has enabled us to understand genetic backgrounds regulating the susceptibility to the specific environmental factors. These progress may bring us new strategies for diagnosis and/or prevention of diseases. In this review, we mainly discuss the current knowledge of these genetic analysis and perspectives in cardiovascular diseases. We also present briefly genetic mutations in cardiomyopathy, long QT syndrome, congenital cardiovascular diseases and so on. Additionally, we describe considerable problems about the interpretation and notification of the results of genetic diagnosis.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo.
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: R
authors.initials: R
authors.lastname: Nagai
mesh_terms: D001779:Blood Coagulation Factors / Q000235:genetics; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000235:genetics*; D006711:Homocystine / Q000378:metabolism; D006801:Humans; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000235:genetics; D020412:Multifactorial Inheritance; D019001:Nitric Oxide Synthase / Q000235:genetics; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics
chemical_list: D001779:Blood Coagulation Factors; D006711:Homocystine; D019001:Nitric Oxide Synthase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP)