Central diabetes insipidus preceding acute myeloid leukemia with t(3;12)(q26;p12).
A 52-year-old woman presented with polyuria and polydipsia. A diagnosis of central diabetes insipidus (DI) was made, which turned out to be the first sign of acute myeloid leukemia (AML). Cytogenetic analysis revealed a balanced translocation between chromosome 3 and 12 t(3;12)(q26;p12). The patient was treated with standard induction chemotherapy and vasopressin. Before consolidation chemotherapy could be administered, deep venous thrombosis was diagnosed and leukemia relapsed. Rescue chemotherapy was started. This is the first report of an association between AML with t(3;12) and DI. Its possible pathogenesis is discussed with a review of the literature.
Nieboer
P
P
Department of Internal Medicine, University Hospital Groningen, The Netherlands. p.nieboer@int.azg.nl
Vellenga
E
E
Adriaanse
R
R
van de Loosdrecht
A A
AA
D000208:Acute Disease; D002881:Chromosomes, Human, Pair 12; D002893:Chromosomes, Human, Pair 3; D003919:Diabetes Insipidus / Q000209:etiology*; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications* / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic