Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development.
A new germinal center kinase (GCK) family kinase, Misshapen/NIKs-related kinase (MINK), has been cloned and its expression has been characterized in several tissues and various developmental stages of the mouse brain. MINK encodes a 1300 amino acid polypeptide, consisting of an N-terminal kinase domain, a proline-rich intermediate region, and a C-terminal GCK homology region. The expression of MINK is up-regulated during the postnatal development of the mouse brain. MINK activates the cJun N-terminal kinase and the p38 pathways.
Dan
I
I
Kusumi Membrane Organizer Project, ERATO, JST, 5-11-33 Chiyoda, Nagoya, Japan.
Watanabe
N M
NM
Kobayashi
T
T
Yamashita-Suzuki
K
K
Fukagaya
Y
Y
Kajikawa
E
E
Kimura
W K
WK
Nakashima
T M
TM
Matsumoto
K
K
Ninomiya-Tsuji
J
J
Kusumi
A
A
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D002460:Cell Line; D003001:Cloning, Molecular; D004789:Enzyme Activation; D018507:Gene Expression Regulation, Developmental; D000081410:Germinal Center Kinases; D051379:Mice; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics*; D010802:Phylogeny; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D015398:Signal Transduction; D014162:Transfection; D015854:Up-Regulation
D000081410:Germinal Center Kinases; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D017346:Protein Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases