title: Primary lymphoepithelioma-like carcinoma of the lung.
abstract: Lymphoepithelioma is an undifferentiated carcinoma with prominent lymphoid stroma in the nasopharynx. Tumors with similar histology have been reported with other localizations, including the lungs, and are designated as lymphoepithelioma-like carcinomas (LELC). Primary LELC of the lung is very rare, and scant information is available in the scientific literature. This paper details the case of a 25-year-old Caucasian male patient with the diagnosis (determined by thoracotomy) of primary LELC of the lung. Immunohistochemical analysis was negative for Epstein-Barr virus, as was the in situ hybridization of the tumor cells. Observation of the nasopharynx and a magnetic resonance image of the cavum were normal. Because the tumor (T4N2M0) could not be resected, the patient was treated with chemotherapy, carboplatin/5-fluorouracil, completing two cycles. The patient's condition worsened when he developed contralateral pneumonia, which was then followed by pericardial effusion. The patient died 36 h later from cardiac tamponade. Presented here is a revision of this rare pathology, not often reported in the literature.
authors.affiliation: Department of Pneumology, Centro Hospitalar de Vila Nova de Gaia, Rua Conceição Fernandes, 4430, Vila Nova de Gaia, Portugal. barroso.pneumo@clix.pt
authors.forename: A
authors.initials: A
authors.lastname: Barroso
authors.forename: R
authors.initials: R
authors.lastname: Nogueira
authors.forename: H
authors.initials: H
authors.lastname: Lencastre
authors.forename: J
authors.initials: J
authors.lastname: Seada
authors.forename: B
authors.initials: B
authors.lastname: Parente
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D016190:Carboplatin; D005472:Fluorouracil