Induction of tissue plasminogen activator in differentiated NG108-15 cells.
Plasminogen activators may facilitate neurite outgrowth and neuronal migration in the developing nervous system. The expression of tissue plasminogen activator by NG108-15 neuroblastoma grown under a variety of conditions has been explored. High tissue plasminogen mRNA expression correlates with growth conditions which induce morphological differentiation and neurite outgrowth; however, NG108-15 cells grown in suspension with dibutyryl-cAMP also show a high level of tissue plasminogen activator expression.
Friedman
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GC
Department of Biochemistry, University of Colorado Health Sciences Center, Denver, CO, USA.
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D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D002454:Cell Differentiation / Q000502:physiology; D003470:Culture Media / Q000494:pharmacology; D005326:Fetal Proteins / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000502:physiology*; D009447:Neuroblastoma; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D012333:RNA, Messenger / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000235:genetics*; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000201:enzymology
D003470:Culture Media; D005326:Fetal Proteins; D012333:RNA, Messenger; D003994:Bucladesine; D010959:Tissue Plasminogen Activator