Pharmacokinetic interaction between diltiazem and tolbutamide.
The effect of co-administered tolbutamide and diltiazem on each drug's pharmacokinetics was studied in eight healthy male volunteers aged 21-25 years, with a 3 x 3 randomised crossover design. Each subject received orally 60 mg of diltiazem hydrochloride or 500 mg of tolbutamide, or both drugs. The washout period between each treatment was 7 days. Serum levels of diltiazem and tolbutamide were determined by HPLC. Serum profiles were analysed using a non-compartmental model. There was no change in the pharmacokinetics of diltiazem in the presence of tolbutamide. There was approximately 10% increase in AUC0-24 and Cmax for tolbutamide in the presence of diltiazem.
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Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Rao
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D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D018592:Cross-Over Studies; D004110:Diltiazem / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004338:Drug Combinations; D004347:Drug Interactions; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D014044:Tolbutamide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000959:Antihypertensive Agents; D004338:Drug Combinations; D007004:Hypoglycemic Agents; D014044:Tolbutamide; D004110:Diltiazem