Microcalorimetric studies of the toxic action of La3+ in mitochondria isolated from Star-cross 288 chicken heart tissue cells.
The thermogenic curves of the metabolism of mitochondria isolated from the heart of chicken Star-cross 288 and the effect of La3+ on it were studied by using an LKB-2277 BioActivity Monitor, ampoule method, at 37 degrees C. After isolation from the chicken heart tissue, mitochondria still have metabolic activity and can live for a long time by using the stored nutrients. From the thermogenic curves, we obtained the thermokinetic equations under different conditions. The kinetics show that La3+ has changed the metabolism completely.
Yi
L
L
Department of Chemistry, Wuhan University, People's Republic of China.
Fengjiao
D
D
Ruming
Z
Z
Xuesong
S
S
Cunxin
W
W
Song-sheng
Q
Q
D000818:Animals; D001681:Biological Assay / Q000379:methods; D002153:Calorimetry, Indirect; D002645:Chickens; D006321:Heart / Q000187:drug effects*; D007811:Lanthanum / Q000633:toxicity*; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D009206:Myocardium / Q000166:cytology / Q000473:pathology; D011868:Radioisotopes / Q000633:toxicity*; D013816:Thermodynamics
D011868:Radioisotopes; D007811:Lanthanum