title: Simultaneous presence of C-ANCA and P-ANCA in a patient with concurrent Churg-Strauss syndrome and giant cell temporal arteritis.
abstract: We herein describe the case of a 77-year-old woman, who presented clinical and histopathological evidence of giant cell arteritis (GCA) involving the temporal artery, together with a Churg-Strauss syndrome (CSS). Our patient presented positive anti-neutrophil cytoplasmic antibodies (ANCA), with cytoplasmic staining pattern (C-ANCA) that was specific against proteinase 3 (PR3), and also a perinuclear pattern (P-ANCA) with specificity against myeloperoxidase (MPO). To our knowledge, the simultaneous presence in the same patient of both types of antibodies has not been previously reported.
authors.affiliation: Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Guardiola
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Pla
authors.forename: J
authors.initials: J
authors.lastname: López-Contreras
authors.forename: J M
authors.initials: JM
authors.lastname: Llobet
authors.forename: P
authors.initials: P
authors.lastname: Domingo
authors.forename: M
authors.initials: M
authors.lastname: Franco
authors.forename: C
authors.initials: C
authors.lastname: Díaz
authors.forename: G
authors.initials: G
authors.lastname: Vázquez
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D000918:Antibody Specificity; D015415:Biomarkers; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D003593:Cytoplasm / Q000201:enzymology / Q000276:immunology; D005260:Female; D013700:Giant Cell Arteritis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D053146:Myeloblastin; D009195:Peroxidase / Q000276:immunology; D012697:Serine Endopeptidases / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D009195:Peroxidase; D012697:Serine Endopeptidases; D053146:Myeloblastin