title: [Polychemotherapy-induced changes in the antioxidant state of blood in patients with inoperable cancer of the stomach].
abstract: Changes in antioxidant characteristics of blood in patients with inoperable tumors of the stomach were followed before and after combination polychemotherapy which comprised intraperitoneal and endolymphatic injection of drugs. General strengthening therapy was given prior to treatment. It was found that enzymatic activity as a component of antioxidant defenses offered by lymphocytes is low in such patients which adversely affects the structural and functional integrity of lymphocyte membranes. After chemotherapy, said function improved significantly showing a tendency towards normalizing. This effect correlated with clinical improvement and better quality of life in patients with inoperable gastric tumors.
authors.affiliation: Research Institute of Oncology, Rostov-on-Don.
authors.forename: E M
authors.initials: EM
authors.lastname: Frantsiiants
authors.forename: L A
authors.initials: LA
authors.lastname: Orlovskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Shalashnaia
authors.forename: N V
authors.initials: NV
authors.lastname: Mucienko
authors.forename: B Kh
authors.initials: BKh
authors.lastname: Anapalian
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D000975:Antioxidants / Q000378:metabolism*; D001790:Blood Physiological Phenomena / Q000187:drug effects; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D013274:Stomach Neoplasms / Q000097:blood* / Q000188:drug therapy*
chemical_list: D000975:Antioxidants