title: In vivo and in vitro immunomodulatory activities of Trichilia glabra aqueous leaf extracts.
abstract: The effects of Trichilia glabra (Meliaceae) aqueous leaf extract on mouse lymphocytes were studied. The in vitro proliferation of T and B lymphocytes was completely impaired. Besides, the extract significantly diminished both antibody and delayed hypersensitivity responses in treated mice. These results suggest that the extract exerts a marked immunomodulatory effect on the murine immune system.
authors.affiliation: Dpto. Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellón II, Piso 4, Ciudad Universitaria, Buenos Aires, Argentina. fbenen@qb.fcen.uba.ar
authors.forename: F
authors.initials: F
authors.lastname: Benencia
authors.forename: M C
authors.initials: MC
authors.lastname: Courrèges
authors.forename: F C
authors.initials: FC
authors.lastname: Coulombié
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000917:Antibody Formation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006968:Hypersensitivity, Delayed; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts