title: Two-dimensional finite element modelling of the neonatal head.
abstract: Electrical impedance tomography (EIT) could allow the early diagnosis of infant brain injury following birth asphyxia. The purpose of this work was to determine the effect of variations in skull, scalp or cerebrospinal fluid (CSF) resistivity, as these vary in clinical conditions and could degrade image quality. These factors were investigated using finite element models of the adult and neonatal head. The results suggest that there is a wide range over which the resistivity of the neonatal skull has little effect on the sensitivity to a central impedance change. The scalp and CSF appear to shunt current away from the brain; when their resistivity was decreased from normal values, this shunting effect increased and caused a decrease in sensitivity to a central resistance change. The resistivity of neonatal skull has not, to our knowledge, been directly measured and will anyway vary within and between individuals; this work suggests that EIT will be relatively insensitive to variations in neonatal skull impedance.
authors.affiliation: Department of Clinical Neurophysiology, University College, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Gibson
authors.forename: R H
authors.initials: RH
authors.lastname: Bayford
authors.forename: D S
authors.initials: DS
authors.lastname: Holder
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000502:physiology; D017097:Electric Impedance; D006257:Head / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007231:Infant, Newborn; D008953:Models, Anatomic; D008954:Models, Biological; D012535:Scalp / Q000033:anatomy & histology / Q000502:physiology; D012886:Skull / Q000033:anatomy & histology / Q000502:physiology; D014054:Tomography / Q000379:methods* / Q000706:statistics & numerical data