title: Physical, chemical, and biological evaluations of P760: a new gadolinium complex characterized by a low rate of interstitial diffusion.
abstract: An original gadolinium chelate, termed P760, which diffuses through the vascular endothelium but at a much lower rate than nonspecific agents (NSA), is described. P760 is a gadolinium macrocyclic compound based on a DOTA structure that is substituted by hydrophilic bulky groups branched on the amino-carboxylic residues. The molecular weight is 5293, and the molecular volume, measured by light scattering, is 30 times higher (11.5 nm3) than that of gadolinium (Gd)-DOTA (0.38 nm3). The increase in molecular volume and weight has two consequences: a) higher relaxivity (r1; 24.7 mM-1.s-1 compared with 3.4 mM-1.s-1 for Gd-DOTA at 20 Mhz, 37 degrees C); and b) a lengthening of its transport rate through the endothelium. P760 presents a peculiar pharmacokinetic profile: at early times post injection, the blood concentrations are higher than those of Gd-DOTA, but after 20 minutes, the blood concentrations are equal for the two compounds. The body clearances of the products are identical (i.e., glomerular filtration rate). P760 molecules are large enough to have a restricted diffusion through the endothelium but, conversely, small enough to pass freely through the glomerular membrane. This limited extravasation has been observed in rabbits by magnetic resonance angiography or in investigations of tumor permeability. Further experimental imaging studies are needed to define the clinical interest of such properties.
authors.affiliation: Guerbet Research Division, Roissy, France. corotc@guerbet-group.com
authors.forename: C
authors.initials: C
authors.lastname: Corot
authors.forename: M
authors.initials: M
authors.lastname: Port
authors.forename: I
authors.initials: I
authors.lastname: Raynal
authors.forename: A
authors.initials: A
authors.lastname: Dencausse
authors.forename: M
authors.initials: M
authors.lastname: Schaefer
authors.forename: O
authors.initials: O
authors.lastname: Rousseaux
authors.forename: C
authors.initials: C
authors.lastname: Simonot
authors.forename: L
authors.initials: L
authors.lastname: Devoldere
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: M
authors.initials: M
authors.lastname: Foulon
authors.forename: P
authors.initials: P
authors.lastname: Bourrinet
authors.forename: B
authors.initials: B
authors.lastname: Bonnemain
authors.forename: D
authors.initials: D
authors.lastname: Meyer
mesh_terms: D000818:Animals; D002199:Capillary Permeability; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics; D004058:Diffusion; D004730:Endothelium, Vascular / Q000378:metabolism; D005682:Gadolinium; D008297:Male; D008536:Meglumine / Q000737:chemistry / Q000493:pharmacokinetics; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C120577:gadolinium compound P760; D008536:Meglumine; D005682:Gadolinium; C072417:gadoterate meglumine