title: Effects of resistance training on bone parameters in young and mature rats.
abstract: 1. Osteoporosis is a major public health problem that is predicted to worsen over the next decade and preventative strategies that increase bone strength have become the focus of substantial research. 2. Although mechanical load is a primary factor in the acquisition and maintenance of skeletal tissue, the type of exercise used and when in life it is most effectively prescribed remain inconclusive. 3. The present study compared 10 weeks of resistance training in both young and mature female Sprague-Dawley rats and measured bone density and body composition by dual energy X-ray absorptiometry and biomechanical properties by three point bending tests of the tibia and femur. 4. No significant differences were observed for any of the bone parameters when comparing exercise and control groups at either age. This was despite using a comparable training protocol to that in humans and using loads of approximately 150% bodyweight. 5. The present study concludes that more intensive work programmes of resistance training or different outcome measures are required when using animal models for skeletal research.
authors.affiliation: School of Physiotherapy, University of Melbourne, Carlton, Victoria, Australia. k.bennell@physio.unimelb.edu.au
authors.forename: K
authors.initials: K
authors.lastname: Bennell
authors.forename: C
authors.initials: C
authors.lastname: Page
authors.forename: K
authors.initials: K
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Warmington
authors.forename: D
authors.initials: D
authors.lastname: Plant
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Palamara
authors.forename: D
authors.initials: D
authors.lastname: Williams
authors.forename: J D
authors.initials: JD
authors.lastname: Wark
mesh_terms: D000367:Age Factors; D000818:Animals; D001696:Biomechanical Phenomena; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D015900:Radiography, Dual-Energy Scanned Projection; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000000981:diagnostic imaging / Q000502:physiology