title: Morphology of the designed biodegradable cisplatin microsphere.
abstract: We observed the morphological changes in microspheres containing cisplatin (CDDP) embedded in poly-d,l,-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS). The in vitro release of CDDP from CDDP-PPMS continued for more than four weeks. Scanning electron microscopy revealed that though the particles of CDDP-PPMS were spherical and superficially smooth, small pores with a superficial irregularity appeared six months later. CDDP-PPMS particles were found in the stomata of the omentum after intraperitoneal administration. When CDDP-PPMS was administered after Yoshida sarcoma cells were intraperitoneally transplanted, CDDP-PPMS was observed histologically in the necrotic tissues of the omentum. These experimental results confirmed the release of CDDP from CDDP-PPMS and the histological efficacy of CDDP-PPMS in the omentum against peritoneal metastasis.
authors.affiliation: First Department of Surgery, Kagoshima University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Natsugoe
authors.forename: K
authors.initials: K
authors.lastname: Tokuda
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Kumanohoso
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: S
authors.initials: S
authors.lastname: Takao
authors.forename: M
authors.initials: M
authors.lastname: Tabata
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Yoshizawa
authors.forename: T
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D002945:Cisplatin / Q000008:administration & dosage*; D004337:Drug Carriers; D008297:Male; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009852:Omentum / Q000473:pathology; D051381:Rats
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D002945:Cisplatin