Utility of c-erbB-2 expression in tissue and sera of ovarian cancer patients.
In this study, expression of the c-erbB-2 gene in tumors and healthy tissue of patients with ovarian cancer was investigated. Serum c-erbB-2 protein levels were also determined. Elevated serum values were observed in 45% of patients. c-erbB-2 protein levels in the tumors were significantly higher than in healthy tissue. Overexpression of the protein was observed in 60% of patients. However, no association was found between the clinical variables and tumor c-erbB-2 expression. This is the first study in the literature investigating the c-erbB-2 oncoprotein levels in the normal and tumor tissue. We conclude that the role of the c-erbB-2 gene in ovarian cancer warrants further studies.
Yazici
H
H
I.U. Oncology Institute, Department of Basic Oncology, Capa, Istanbul, Turkey.
Dolapcioglu
K
K
Buyru
F
F
Dalay
N
N
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000097:blood / Q000737:chemistry*; D010053:Ovary / Q000737:chemistry; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000097:blood
D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases