Mammary gland oncogenes as indicators of pathways important in mammary gland development.
The identification of dominant acting proto-oncogenes in mammary tumors from mice and humans has highlighted a number of signal transduction pathways that have subsequently been shown to have a role in normal mammary growth and differentiation. Here we describe the use of two different transgenic mouse strategies to investigate the function of two of these signalling pathways in the normal growth and differentiation of the mouse mammary gland during pregnancy.
Dickson
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C
Imperial Cancer Research fund, Lincoln's Inn Fields, London WC2A 3PX, UK.
Creer
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A
Fantl
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V
D000818:Animals; D002454:Cell Differentiation; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000166:cytology / Q000254:growth & development*; D008325:Mammary Neoplasms, Experimental / Q000235:genetics; D051379:Mice; D009857:Oncogenes; D011247:Pregnancy; D017978:Receptors, Growth Factor / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
D006133:Growth Substances; D017978:Receptors, Growth Factor; D019938:Cyclin D1