title: Evaluation of tickGARD(PLUS), a novel vaccine against Boophilus microplus, in lactating Holstein-Friesian cows.
abstract: The effects of vaccination with the Bm 86 vaccine TickGARD(PLUS) against infestation with cattle tick (Boophilus microplus) and of holding cattle on a feedpad until 09:00 hours after the morning milking was tested on 40 mid lactation Holstein cattle using a factorial design. Vaccination resulted in a 56% reduction in tick numbers in the field over one generation, and a 72% reduction in laboratory measures of the reproductive efficiency of ticks. The liveweight gain of vaccinated cattle over 27 weeks was 18.6 kg higher than that of controls, and vaccinated cattle tended to have lower somatic cell count in milk (SCC). There were no other significant differences in measures of production. Cattle kept on the feedpad after the morning milking carried 26% more ticks than those returned immediately to their paddocks.
authors.affiliation: Department of Primary Industries, Queensland Australian Tropical Dairy Institute, Mutdapilly Research Station, Peak Crossing. n.jonsson@vet.gla.ac.uk
authors.forename: N N
authors.initials: NN
authors.lastname: Jonsson
authors.forename: A L
authors.initials: AL
authors.lastname: Matschoss
authors.forename: P
authors.initials: P
authors.lastname: Pepper
authors.forename: P E
authors.initials: PE
authors.lastname: Green
authors.forename: M S
authors.initials: MS
authors.lastname: Albrecht
authors.forename: J
authors.initials: J
authors.lastname: Hungerford
authors.forename: J
authors.initials: J
authors.lastname: Ansell
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood; D001835:Body Weight; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology / Q000517:prevention & control*; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D005260:Female; D005298:Fertility; D007774:Lactation; D008892:Milk / Q000378:metabolism; D011793:Queensland; D011897:Random Allocation; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D013987:Ticks / Q000276:immunology* / Q000502:physiology; D014611:Vaccination / Q000379:methods / Q000662:veterinary*; D019444:Vaccines, DNA / Q000276:immunology / Q000592:standards
chemical_list: D000906:Antibodies; D019444:Vaccines, DNA