The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family.
Here we report the identification of Dfz3, a novel member of the Frizzled family of seven-pass transmembrane receptors. Like Dfz2, Dfz3 is a target gene of Wingless (Wg) signalling, but in contrast to Dfz2, it is activated rather than repressed by Wg signalling in imaginal discs. We show that Dfz3 is not required for viability but is necessary for optimal Wg signalling at the wing margin.
Sivasankaran
R
R
Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.
Calleja
M
M
Morata
G
G
Basler
K
K
D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D017344:Genes, Insect; D019476:Insect Proteins / Q000235:genetics* / Q000502:physiology; D008969:Molecular Sequence Data; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics* / Q000502:physiology; D043562:Receptors, G-Protein-Coupled; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D051157:Frizzled Receptors; D019476:Insect Proteins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D051155:Wnt1 Protein; C400046:fz3 protein, Drosophila; C074622:wg protein, Drosophila