Pathogenicity of a new neurotropic equine herpesvirus 9 (gazelle herpesvirus 1) in horses.
Pathogenicity of equine herpesvirus 9 (EHV-9), a new type of equine herpesvirus isolated from Gazella thomsoni, in horses was investigated by intranasal inoculation of EHV-9 (10(7) pfu) to two conventionally reared 8-months old half-bred weanling horses. Fever higher than 39 degrees C was recorded. Virus was recovered from nasal swabs and peripheral blood mononuclear cells. Both horses developed neutralizing antibody to EHV-9. Perivascular infiltration of mononuclear cells and glial reaction were found in the olfactory and limbic systems. The results suggested that EHV-9 has a pathogenicity in horses.
Taniguchi
A
A
Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
Fukushi
H
H
Matsumura
T
T
Yanai
T
T
Masegi
T
T
Hirai
K
K
D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000473:pathology / Q000821:virology; D002460:Cell Line; D004285:Dogs; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D006734:Horse Diseases / Q000473:pathology / Q000821:virology*; D006736:Horses; D008168:Lung / Q000473:pathology / Q000821:virology; D009500:Neutralization Tests / Q000662:veterinary; D018140:Varicellovirus / Q000472:pathogenicity*; D017201:Virus Shedding