Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease.
Oligodendrocyte-specific protein (OSP/claudin-11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin-11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin-11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin-11 as an autoantigen in the development of autoimmune demyelinating disease.
Bronstein
J M
JM
Departments of Neurology and the Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA. jbronste@ucla.edu
Tiwari-Woodruff
S
S
Buznikov
A G
AG
Stevens
D B
DB
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D057167:Claudins; D020278:Demyelinating Autoimmune Diseases, CNS / Q000503:physiopathology*; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*
C120453:CLDN11 protein, human; D057167:Claudins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins