title: Aromatase and sulfatase inhibitors from Lepiota americana.
abstract: From an edible mushroom Lepiota americana Pk., (Agaricaceae), 2-aminophenoxazin-3-one that inhibited aromatase at IC50 = 5.7 microM and 3 beta-hydroxy-5,8-epidioxyergosta-6,22-diene that inhibited sulfatase at IC50 = 0.9 microM were isolated. Neither 2-aminophenoxazin-3-one was active against sulfatase nor was 3 beta-hydroxy-5,8-epidioxyergosta-6,22-diene active against aromatase.
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
authors.forename: K P
authors.initials: KP
authors.lastname: Bhat
authors.forename: S Y
authors.initials: SY
authors.lastname: Park
authors.forename: S H
authors.initials: SH
authors.lastname: Kang
authors.forename: E H
authors.initials: EH
authors.lastname: Yoo
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: H W
authors.initials: HW
authors.lastname: Lee
authors.forename: R J
authors.initials: RJ
authors.lastname: Krueger
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010078:Oxazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013429:Sulfatases / Q000037:antagonists & inhibitors*
chemical_list: D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D010078:Oxazines; C005512:3-aminophenoxazone; D013429:Sulfatases; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol