Novel oximes having 5-benzyl-2,4-thiazolidinedione as antihyperglycemic agents: synthesis and structure-activity relationship.
Oximes having 5-benzyl-2,4-thiazolidinedione were prepared, and their PPAR gamma agonistic activities and blood glucose lowering activities were evaluated. Biaromatic and methyl groups, attached to the oxime moiety, and the ethylene bridge between oxime and phenoxy groups are favorable to biological activities.
Yanagisawa
H
H
Medicinal Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. hyanag@shina.sankyo.co.jp
Takamura
M
M
Yamada
E
E
Fujita
S
S
Fujiwara
T
T
Yachi
M
M
Isobe
A
A
Hagisawa
Y
Y
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004341:Drug Evaluation; D006943:Hyperglycemia / Q000097:blood / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology; D007536:Isomerism; D051379:Mice; D008815:Mice, Inbred Strains; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000378:metabolism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014157:Transcription Factors / Q000819:agonists / Q000378:metabolism
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010091:Oximes; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D014157:Transcription Factors