title: Treatment with ibandronate preserves bone in experimental tumour-induced bone loss.
abstract: Cancer-induced bone diseases are often associated with increased bone resorption and pathological fractures. In recent years, osteoprotective agents such as bisphosphonates have been studied extensively and have been shown to inhibit cancer-related bone resorption in experimental and clinical studies. The third-generation bisphosphonate, ibandronate (BM 21.0955), is a potent compound for controlling tumour osteolysis and hypercalcaemia in rats bearing Walker 256 carcinosarcoma. We have studied the effect of ibandronate given as an interventional treatment on bone strength and bone loss after the onset of tumour growth in bone. Our results suggest that it is capable of preserving bone quality in rats bearing Walker 256 carcinosarcoma cells. Since other bisphosphonates have produced comparable results in man after their success in the Walker 256 animal models our findings suggest that ibandronate may be a powerful treatment for maintaining skeletal integrity in patients with metastatic bone disease.
authors.affiliation: Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Centre and Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Kurth
authors.forename: S Z
authors.initials: SZ
authors.lastname: Kim
authors.forename: I
authors.initials: I
authors.lastname: Sedlmeyer
authors.forename: L
authors.initials: L
authors.lastname: Hovy
authors.forename: F
authors.initials: F
authors.lastname: Bauss
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy* / Q000209:etiology; D002279:Carcinoma 256, Walker / Q000150:complications*; D004164:Diphosphonates / Q000627:therapeutic use*; D000077557:Ibandronic Acid; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004164:Diphosphonates; D000077557:Ibandronic Acid