Isolation of fusobacteria from the oral cavities of malnourished Nigerian children living in agricultural and herding villages.
A previous study demonstrated the presence and possible involvement of Fusobacterium necrophorum in the pathogenesis of noma lesions of children living in agricultural and herding villages in northwestern Nigeria. In order to determine if F. necrophorum was part of the oral flora of malnourished children with no noma lesions, a study of the fusobacteria present in the oral cavities of 30 children, 2-6 years of age in Sokoto State, was undertaken. Swabs taken of the oral cavity were cultured on selective fusobacteria medium using conventional anaerobic microbiological techniques. F. nucleatum was recovered from each child and F. necrophorum was isolated from the oral cavity of only one child. The presence of F. nucleatum and the lack of F. necrophorum, except in one case, suggests that the latter is not normal flora in the children at risk for noma. F. necrophorum, a putative trigger organism for noma may gain a foothold only when certain staging conditions (i.e., lowered host resistance and/or oral lesion) are present.
Falkler
W A
WA
Department of OCBS, School of Dentistry, University of Maryland, Baltimore, MD, USA. wfalkler@umaryland.edu
Enwonwu
C O
CO
Ewell
A J
AJ
Idigbe
E O
EO
D000693:Anaerobiosis; D001431:Bacteriological Techniques; D002648:Child; D002675:Child, Preschool; D003470:Culture Media; D005673:Fusobacterium / Q000145:classification* / Q000302:isolation & purification; D005674:Fusobacterium Infections; D005675:Fusobacterium necrophorum / Q000254:growth & development; D016967:Fusobacterium nucleatum / Q000254:growth & development; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D009549:Nigeria; D009625:Noma / Q000382:microbiology; D009748:Nutrition Disorders / Q000382:microbiology*; D012307:Risk Factors; D012423:Rural Health
D003470:Culture Media