Toward antiviral strategies that resist viral escape.
We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug design strategy that would hinder the development of drug resistance.
Endy
D
D
Department of Chemical Engineering, University of Wisconsin-Madison, Madison, WI 53706-1691, USA.
Yin
J
J
D000998:Antiviral Agents / Q000494:pharmacology*; D017123:Bacteriophage T7 / Q000187:drug effects / Q000235:genetics; D003198:Computer Simulation; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D016372:RNA, Antisense / Q000378:metabolism; D012367:RNA, Viral / Q000096:biosynthesis; D014780:Viruses / Q000187:drug effects*
D000998:Antiviral Agents; D016372:RNA, Antisense; D012367:RNA, Viral