Hepatitis delta virus: molecular biology, pathogenesis and immunology.
Hepatitis delta virus (HDV) is a unique infectious agent which causes severe liver disease in those infected with its helper virus, hepatitis B virus. No effective antiviral therapy for HDV exists. This review covers recent advances in the molecular biology, pathogenesis and immunology of HDV, with an emphasis on potential targets for the development of successful antiviral agents.
Casey
J L
JL
Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Maryland, USA. caseyj@medlib.georgetown.edu
D005838:Genotype; D006508:Hepatitis Antibodies / Q000097:blood; D018963:Hepatitis Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000502:physiology; D019701:Hepatitis D, Chronic / Q000209:etiology* / Q000276:immunology / Q000821:virology; D003698:Hepatitis Delta Virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D006801:Humans; D012367:RNA, Viral / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology; D014779:Virus Replication
D006508:Hepatitis Antibodies; D018963:Hepatitis Antigens; D012367:RNA, Viral