title: Human retinal astroglia. A comparative study of adult and the 18 month postnatal developmental stage.
abstract: The immunohistochemical location of glial fibrillary acidic protein (GFAP) was used to study the state of maturation of retinal astrocytes from an 18-mo-old infant and to compare it with the situation in the adult. Infant astrocytes showed intense GFAP immunoreactivity in the perikarya and possessed spindle-like enlargements in their processes, while in the adult immunoreactivity in the perikarya was scarce and the spindle-like enlargements were not evident. Two types of astrocyte were observed in adult and child retinas: elongated and star-shaped. In the adult, the star-shaped type tend to be more stylised and to have longer processes than in the infant. In the infant, numerous astrocyte cell bodies were observed over vessels, while in the adult these were scarce. In the infant, the star-shaped astrocytes made up a honeycomb plexus, but this was not fully developed. These results suggest that at 18 mo of postnatal development the retinal astrocytes are still increasing and growing into the astroglial structure found in adults.
authors.affiliation: Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Facultad de Medicina, Universidad Complutense Madrid, Spain. atrivino@med.ucm.es
authors.forename: A
authors.initials: A
authors.lastname: Triviño
authors.forename: J M
authors.initials: JM
authors.lastname: Ramírez
authors.forename: J J
authors.initials: JJ
authors.lastname: Salazar
authors.forename: A I
authors.initials: AI
authors.lastname: Ramírez
mesh_terms: D000328:Adult; D001253:Astrocytes / Q000166:cytology / Q000502:physiology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D012160:Retina / Q000166:cytology / Q000254:growth & development*
chemical_list: D005904:Glial Fibrillary Acidic Protein