Endothelium-derived factors in microalbuminuric and nonmicroalbuminuric essential hypertensives.
Previous evidence has demonstrated a relationship between growth factors and cardiovascular diseases. This study was aimed at evaluating levels of some endothelium-derived growth factors, and their relationship with microalbuminuria (MAU), in essential hypertension. Ninety-nine mild-moderate essential hypertensives (EH) and 25 healthy controls were studied. All patients underwent 24-h blood pressure monitoring, serum endothelin-1 (ET-1), basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF), and 24-h MAU assays. Later, EH were divided into two subsets consisting of microalbuminurics (MAU >11 microg/min) and nonmicroalbuminurics (MAU <11 microg/min). In microalbuminuric EH, circulating ET-1, bFGF, and PDGF were significantly higher than in nonmicroalbuminurics (P < .0001, P < .0001, P < .005, respectively) or in controls. In the group of 99 EH, significant positive correlations of MAU with both ET-1 and bFGF (r = 0.35, P < .001, and r = 0.34, P < .001, respectively) were found. ET-1 and bFGF correlated significantly (r = 0.31, P < .002). Circulating bFGF also correlated significantly with MAU in the microalbuminuric EH subset (r = 0.49, P < .01). Our results show that in microalbuminuric EH circulating levels of certain growth factors are increased. In human essential hypertension these factors are linked with MAU, an early cardiovascular and renal damage marker.
Cottone
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Cattedra di Medicina Interna, Istituto di Clinica Medica e Malattie Cardiovascolari, University of Palermo, Italy. Sancott@tin.it
Vadalà
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Mangano
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Riccobene
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Vella
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Neri
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Mulé
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Piazza
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Amato
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Zagarrigo
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Cerasola
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D000328:Adult; D000419:Albuminuria / Q000097:blood* / Q000209:etiology / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D003404:Creatinine / Q000097:blood / Q000652:urine; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000652:urine; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D013053:Spectrophotometry
D015415:Biomarkers; D019332:Endothelin-1; D010982:Platelet-Derived Growth Factor; D016222:Fibroblast Growth Factor 2; D003404:Creatinine