title: The potential benefits of advanced therapeutic modalities in the treatment of diabetic foot wounds.
abstract: This article discusses the advantages and disadvantages of primary wound healing as compared with primary amputation in individuals with chronic diabetic foot wounds. The authors review the potential benefits of vascular surgical procedures and advanced dressings, including two of the most promising modalities in modern wound care: growth factors and bioengineered skin. In this era of cost-conscious health-care administration, it is incumbent on the practitioner to consider not only the basic science of wound care, but also the economic aspect of treatment rendered. These various interventions, dressings, growth factor delivery systems, and new modalities could significantly reduce healing time, thereby reducing the risk of infection, hospitalization, and amputation while improving quality of life. If so, they may be truly cost-effective.
authors.affiliation: Department of Orthopaedics, University of Texas Health Science Center, San Antonio 78284-7776, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hogge
authors.forename: D
authors.initials: D
authors.lastname: Krasner
authors.forename: H
authors.initials: H
authors.lastname: Nguyen
authors.forename: L B
authors.initials: LB
authors.lastname: Harkless
authors.forename: D G
authors.initials: DG
authors.lastname: Armstrong
mesh_terms: D001458:Bandages; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D017719:Diabetic Foot / Q000191:economics / Q000503:physiopathology / Q000628:therapy*; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D017768:Skin, Artificial; D014945:Wound Healing
chemical_list: D006133:Growth Substances