title: Insulin receptors in the brain cortex of aging mice.
abstract: The aim of the present study was to analyze whether aging also affects central insulin receptors in brain cortex as it does in whole brain of BALB/c-nu mice. Results showed statistically significant decrease of number and increase of affinity of insulin high affinity binding sites in old animals. As a consequence, central insulin actions, among which neuromodulation of monoaminergic system, can result altered during aging.
authors.affiliation: Gerontologic Research Department, Center of Biochemistry, INRCA, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zaia
authors.forename: L
authors.initials: L
authors.lastname: Piantanelli
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D002540:Cerebral Cortex / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011972:Receptor, Insulin / Q000378:metabolism*
chemical_list: D007328:Insulin; D011972:Receptor, Insulin