PF1163A and B, new antifungal antibiotics produced by Penicillium sp. II. Physico-chemical properties and structure elucidation.
The structures of new antifungal antibiotics, PF1163A and B, were elucidated by spectroscopic analyses of the degradation products and by X-ray crystallography of the de-2-hydroxyethyl derivative of PF1163B. Both antibiotics consist of a 13-membered macrocyclic structure containing a derivative of N-methyl tyrosine and a hydroxy fatty acid. PF1163A differs from PF 1163B by having an additional hydroxyl group on the side chain.
Sasaki
T
T
Pharmaceutical Research Center, Meiji Seika, Ltd., Yokohama, Japan.
Nose
H
H
Hosoya
A
A
Yoshida
S
S
Kawaguchi
M
M
Watanabe
T
T
Usui
T
T
Ohtsuka
Y
Y
Shomura
T
T
Takano
S
S
Tatsuta
K
K
D000935:Antifungal Agents / Q000737:chemistry*; D047028:Macrocyclic Compounds; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010407:Penicillium; D013237:Stereoisomerism
D000935:Antifungal Agents; D047028:Macrocyclic Compounds; C405057:PF 1163A; C405058:PF 1163B