Antibody against a novel, myriocin (ISP-I)-based immunosuppressant, FTY720.
An antibody was prepared by immunizing rabbits with an ovalbumin conjugate of 2-amino-2-(2-(4-(4-mercaptobutyl)phenyl)ethyl)propane-1,3-diol HCl (AMPD-4), which contains the essential structure of the novel immunosuppressant FTY720. As the antibody reacted to not only AMPD-4, but also FTY720, it should be useful for immunoassay of FTY720 in body fluids, tissues and cells.
Fujita
T
T
Faculty of Pharmaceutical Sciences, Setsunan University, Osaka, Japan. fujita@pharm.setsunan.ac.jp
Matsumoto
N
N
Uchida
S
S
Kohno
T
T
Shimizu
T
T
Hirose
R
R
Yanada
K
K
Kurio
W
W
Watabe
K
K
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D000918:Antibody Specificity; D003429:Cross Reactions; D004797:Enzyme-Linked Immunosorbent Assay; D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D000068876:Fingolimod Hydrochloride; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D011412:Propanolamines / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D011409:Propylene Glycols / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D011817:Rabbits; D013110:Sphingosine / Q000031:analogs & derivatives
C407725:AMPD 4; D000906:Antibodies; D005229:Fatty Acids, Monounsaturated; D007166:Immunosuppressive Agents; D011412:Propanolamines; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine; C001996:thermozymocidin