title: Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling.
abstract: Long-chain acyl-CoA esters (LCA) act both as substrates and intermediates in metabolism and as regulators of various intracellular functions. Acyl-CoA binding protein (ACBP) binds LCA with high affinity and is believed to play an important role in intracellular acyl-CoA transport and pool formation and therefore also for the function of LCA as metabolites and regulators of cellular functions . The free concentration of cytosolic LCA is efficiently buffered to low nanomole concentration by ACBP and fatty acid binding protein (FABP). An additional important factor is the activity of acyl-CoA hydrolases. The estimated cellular free LCA concentration is two to four orders of magnitude lower than the concentrations reported to be necessary to regulate most LCA-affected cellular functions. Preliminary evidence indicates that the regulatory effect of LCA might be mediated by the LCA/ACBP complex.
authors.affiliation: Institute of Biochemistry, Odense University, Denmark.
authors.forename: J
authors.initials: J
authors.lastname: Knudsen
authors.forename: T B
authors.initials: TB
authors.lastname: Neergaard
authors.forename: B
authors.initials: B
authors.lastname: Gaigg
authors.forename: M V
authors.initials: MV
authors.lastname: Jensen
authors.forename: J K
authors.initials: JK
authors.lastname: Hansen
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology / Q000502:physiology*; D026261:Diazepam Binding Inhibitor; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000214:Acyl Coenzyme A; D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor