Specificity of human antibodies reactive with pneumococcal C polysaccharide.
Antibodies reactive with C polysaccharide (PS) were found in healthy adults, pneumococcal patients, and vaccinees. These antibodies were not directed to the phosphocholine determinant of the C PS, as they appear to be in mice, since the human antibodies were inhibitable only with C PS. We found another population of phosphocholine-specific antibodies inhibitable only by phosphocholine and related compounds.
Frasch
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CE
Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research, Bethesda, Maryland, USA. frasch@cber.fda.gov
Concepcion
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NF
D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology*; D000918:Antibody Specificity; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D010767:Phosphorylcholine / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000097:blood / Q000276:immunology*; D012709:Serum Albumin / Q000276:immunology; D014611:Vaccination; D014612:Vaccines / Q000276:immunology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011135:Polysaccharides, Bacterial; D012709:Serum Albumin; D014612:Vaccines; C027158:polysaccharide C-substance (Streptococcus); D010767:Phosphorylcholine