title: Effects of subdural haematoma on sensorimotor functioning and spatial learning in rats.
abstract: Twenty per cent of all strokes are haemorrhagic in character and are associated with severe disturbances in sensorimotor behaviour and cognition. Although spontaneous recovery of pre-stroke functioning occurs in some cases, the process is demanding, slow, and often incomplete. A first step in the preclinical testing of new putative, neuroprotective and recovery-supporting therapeutics is to validate animal models of brain injury. In a series of four experiments we evaluated the behavioural impairments and the time course of recovery of functional deficits in rats with an experimentally induced subdural haematoma. We found that unilateral subdural haematoma resulted in dysfunction in both simple reflexive (experiment 1) and skilled sensorimotor behaviour (experiment 2). Reflexive behaviour did not recover, or recovered only marginally, and neither did the deficits in skilled forepaw use. Bilateral subdural haematoma impaired the learning and memory performance of adult (experiment 3) and old rats (experiment 4) in the Morris water escape task. Considering the diversity of the deficits found in our experiments, we conclude that different models are needed to cover the broad range of deficits seen in stroke patients.
authors.affiliation: CNS Research, Bayer AG, Pharma Research Center, Building 500, Aprather Weg 18a, D-42096, Wuppertal, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Eijkenboom
authors.forename: I
authors.initials: I
authors.lastname: Gerlach
authors.forename: R
authors.initials: R
authors.lastname: Jork
authors.forename: D
authors.initials: D
authors.lastname: Lowe
authors.forename: F J
authors.initials: FJ
authors.lastname: van der Staay
mesh_terms: D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003337:Corpus Callosum / Q000473:pathology; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D004924:Escape Reaction / Q000502:physiology; D005552:Forelimb / Q000502:physiology; D020199:Hematoma, Subdural, Acute / Q000473:pathology / Q000503:physiopathology*; D006614:Hindlimb / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D009044:Motor Cortex / Q000473:pathology / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D012018:Reflex / Q000502:physiology; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology; D013028:Space Perception