[New findings in orthopedic pathology].
The term orthopedic pathology refers to bone- and joint-affecting diseases which are important for the orthopedic surgeon. In the report presented here, emphasis is placed on the membrane-associated proteolysis, which is essential for the degradation of the extracellular matrix. Matrix-degrading processes play a role not only in arthrosis but also in rheumatoid arthritis. Moreover, they are strongly associated with the problem of loosening of protheses, which is of utmost importance for the orthopedic surgeon. In these processes, major roles are played by the plasminogen activator system, plasmin, different matrix metalloproteinases, including the membrane type matrix metalloproteases and different cathepsins. A deeper insight into the function of these proteins and their influence on the matrix degradation in joint diseases will open the way for new diagnostic and therapeutic strategies. Investigations into a large number of chondrosarcomas have shown that for this type of bone lesions, urokinase plasminogen activator and cathepsin B are prognostic parameters that are independent of the differentiation grade. Also, in this context, investigations into the membrane-bound proteases will be of great practical and diagnostic value.
Roessner
A
A
Institut für Pathologie, Otto-von-Guericke Universität Magdeburg.
Eberhardt
R
R
Häckel
C
C
Pap
G
G
Walter
H
H
Nebelung
W
W
Neumann
H W
HW
D019643:Arthroplasty, Replacement; D015415:Biomarkers; D001847:Bone Diseases / Q000473:pathology* / Q000601:surgery*; D002401:Cathepsin B / Q000032:analysis; D006801:Humans; D007592:Joint Diseases / Q000473:pathology* / Q000601:surgery*; D007595:Joint Prosthesis; D011379:Prognosis; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis
D015415:Biomarkers; D014568:Urokinase-Type Plasminogen Activator; D002401:Cathepsin B