title: Giant negative T waves in Guillain-Barré syndrome.
abstract: A Guillain-Barré syndrome patient showed giant negative T waves on electrocardiography at the height of the disease, with large left ventricular hypokinesis on echocardiography and extensive defects on 123I-meta-iodobenzylguanidine myocardial scintigraphy. Gamma-globulin improved the neurological symptoms, and the above abnormalities resolved. We speculate that cardiac sympathetic nerve endings were transiently damaged, with consequent myocardial injury, due to norepinephrine toxicity.
authors.affiliation: Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Yoshii
authors.forename: R
authors.initials: R
authors.lastname: Kozuma
authors.forename: M
authors.initials: M
authors.lastname: Haida
authors.forename: Y
authors.initials: Y
authors.lastname: Shinohara
authors.forename: M
authors.initials: M
authors.lastname: Yoshitake
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: S
authors.initials: S
authors.lastname: Handa
mesh_terms: D019797:3-Iodobenzylguanidine / Q000031:analogs & derivatives; D000368:Aged; D004452:Echocardiography / Q000379:methods; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000503:physiopathology; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008475:Median Nerve / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D010543:Peroneal Nerve / Q000503:physiopathology; D012720:Severity of Illness Index; D013565:Sympatholytics; D013599:Systole / Q000502:physiology; D013979:Tibial Nerve / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology
chemical_list: D013565:Sympatholytics; C049322:4-amino-3-iodobenzylguanidine; D019797:3-Iodobenzylguanidine