[Anticoagulant activity of coumarins from Ferula communis L].
Ferula communis is an ombelliferous plant of the Mediterranean regions. It is represented in Morocco by two varieties: brevifolia and genuina. The later is very rich in a soap or resinous gum. This product, collected from the roots, is largely used in traditional medicine. It is know as fessoukh in Morocco and other Arab countries. This plant is also well known for its toxicity and its anticoagulant activity. In the present review, are discussed: (1) the ethnobotany of the plant, especially medicinal uses of fessoukh in traditional medicine as well as alimentary use of young stems as legumes; (2) clinical and biochemical data of intoxication by this plant, which are dominated by haemorrhage as a consequence of blood coagulation disturbance; (3) 4-hydroxycoumarins isolated from Ferula communis L. and their anticoagulant activity; (4) the role of vitamin K1 in the treatment of poisoning by this plant.
Lamnaouer
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Institut Agronomique et Vétérinaire Hassan II, Département de Pharmacie Toxicologie et Biochimie, Rabat-Instituts, Maroc.
D015110:4-Hydroxycoumarins / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology* / Q000506:poisoning; D000818:Animals; D000925:Anticoagulants / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology* / Q000506:poisoning; D001779:Blood Coagulation Factors / Q000502:physiology; D005309:Ferula / Q000737:chemistry* / Q000506:poisoning; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D007558:Italy; D009018:Morocco; D010939:Plant Poisoning / Q000188:drug therapy / Q000662:veterinary; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced; D010837:Vitamin K 1 / Q000502:physiology / Q000627:therapeutic use
D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D001779:Blood Coagulation Factors; D010837:Vitamin K 1; C068805:4-hydroxycoumarin