Spectrophotometric methods for the determination of benazepril hydrochloride in its single and multi-component dosage forms.
Three sensitive and accurate methods are presented for the determination of benazepril in its dosage forms. The first method uses derivative spectrophotometry to resolve the interference due to formulation matrix. The second method depends on the color formed by the reaction of the drug with bromocresol green (BCG). The third one utilizes the reaction of benazepril, after alkaline hydrolysis, with 3-methylbenzothialozone (MBTH) hydrazone where the produced color is measured at 593 nm. The latter method was extended to develop a stability-indicating method for this drug. Moreover, the derivative method was applied for the determination of benazepril in its combination with hydrochlorothiazide. The proposed methods were applied for the analysis of benazepril in the pure form and in tablets. The coefficient of variation was less than 2%.
El-Yazbi
F A
FA
Faculty of Pharmacy, Alexandria University, El-Mesallah, Egypt.
Abdine
H H
HH
Shaalan
R A
RA
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D001552:Benzazepines / Q000032:analysis*; D001961:Bromcresol Green; D004232:Diuretics; D004338:Drug Combinations; D004355:Drug Stability; D006835:Hydrazones / Q000032:analysis; D006852:Hydrochlorothiazide / Q000032:analysis; D007202:Indicators and Reagents; D015203:Reproducibility of Results; D049993:Sodium Chloride Symporter Inhibitors; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets; D013844:Thiazoles / Q000032:analysis
C405983:3-methylbenzothiazolone hydrazone; D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D004232:Diuretics; D004338:Drug Combinations; D006835:Hydrazones; D007202:Indicators and Reagents; D049993:Sodium Chloride Symporter Inhibitors; D012996:Solutions; D013607:Tablets; D013844:Thiazoles; D006852:Hydrochlorothiazide; D001961:Bromcresol Green; C044946:benazepril