Effects of neonatal treatment with Tyr-MIF-1 and naloxone on the long-term body weight gain induced by repeated postnatal stressful stimuli.
Stressful stimuli repeatedly applied during the first postnatal weeks can induce body weight gain in the mouse during adulthood. This effect can be prevented by injecting naloxone concomitantly with stress. The peptides belonging to the Tyr-MIF-1 family have a great modulating activity on numerous stress-induced phenomena. The aim of the present work was to compare the effect of repeated neonatal injections of Tyr-MIF-1 or naloxone on the long-term body weight gain induced by a stressing procedure applied daily during the first three weeks of life. The results indicate that although naloxone blocked the development of the stress-induced effects, Tyr-MIF-1 potentiated them.
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Laboratorio di Alimenti, Istituto Superiore di Sanità, Rome, Italy. damore.antonio@pop.tiscalinet.it
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D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000818:Animals; D000831:Animals, Newborn; D004435:Eating / Q000187:drug effects; D009075:MSH Release-Inhibiting Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D018847:Opioid Peptides / Q000502:physiology; D013312:Stress, Physiological / Q000473:pathology* / Q000503:physiopathology*; D015430:Weight Gain / Q000187:drug effects*
D009292:Narcotic Antagonists; D018847:Opioid Peptides; D009270:Naloxone; C036930:tyrosyl-prolyl-leucyl-glycinamide; D009075:MSH Release-Inhibiting Hormone