The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response.
Although Drosophila possesses potent immune responses, little is known about the microbial pathogens that infect Drosophila. We have identified members of the bacterial genus Erwinia that induce the systemic expression of genes encoding antimicrobial peptides in Drosophila larvae after ingestion. These Erwinia strains are phytopathogens and use flies as vectors; our data suggest that these strains have also evolved mechanisms for exploiting their insect vectors as hosts. Erwinia infections induce an antimicrobial response in Drosophila larvae with a preferential expression of antibacterial versus antifungal peptide-encoding genes. Antibacterial peptide gene expression after Erwinia infection is reduced in two Drosophila mutants that have reduced numbers of hemocytes, suggesting that blood cells play a role in regulating Drosophila antimicrobial responses and also illustrating that this Drosophila-Erwinia interaction provides a powerful model for dissecting host-pathogen relationships.
Basset
A
A
Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette Cedex, France.
Khush
R S
RS
Braun
A
A
Gardan
L
L
Boccard
F
F
Hoffmann
J A
JA
Lemaitre
B
B
D000818:Animals; D030801:Animals, Genetically Modified; D004330:Drosophila / Q000276:immunology / Q000382:microbiology*; D029721:Drosophila Proteins; D015964:Gene Expression Regulation, Bacterial; D019476:Insect Proteins / Q000235:genetics; D007814:Larva / Q000378:metabolism; D016973:Pectobacterium carotovorum / Q000472:pathogenicity*
C054756:DptA protein, Drosophila; D029721:Drosophila Proteins; D019476:Insect Proteins