E-cadherin at the cell periphery is a determinant of keratinocyte differentiation in vitro.
The origin of the signal for keratinocyte differentiation is still unknown. Here, we show that Ca(2+)- and density-induced translocation of E-cadherin, but not P-cadherin, is accompanied by induction of differentiation-specific proteins in cultured keratinocytes. Antibodies that artificially cluster cell-surface E-cadherin in low extracellular Ca(2+) also induce differentiation-specific proteins, implicating E-cadherin as a determinant of keratinocyte differentiation in vitro.
Owens
D W
DW
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, United Kingdom.
Brunton
V G
VG
Parkinson
E K
EK
Frame
M C
MC
D015820:Cadherins / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002448:Cell Adhesion; D002450:Cell Communication; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011503:Transglutaminases / Q000378:metabolism
D015820:Cadherins; D011498:Protein Precursors; C032253:involucrin; D011503:Transglutaminases; D002118:Calcium