Chronic ulcerative stomatitis: a case report.
BACKGROUND
Certain mucocutaneous diseases present with painful, ulcerative, or erosive oral manifestations. Chronic ulcerative stomatitis is a newly recognized disease of unknown origin which presents clinically with features of desquamative gingivitis. This report marks only the thirteenth case reported in the world literature. A review of previous reports and studies is presented along with a review of immunofluorescence techniques critical to proper diagnosis. These diseases are difficult to diagnose without the use of immunofluorescence techniques. A 54-year-old Caucasian woman presented with a 2- to 3-year history of stomatitis and dry mouth.


METHODS
Direct immunofluorescence revealed a speckled pattern of IgG deposits in the basal one-third of the epithelium, while indirect immunofluorescence confirmed the presence of stratified epithelium-specific antinuclear antigen (SES-ANA), both pathognomonic for chronic ulcerative stomatitis.


RESULTS
The patient was successfully treated using topical corticosteroid therapy.
Lorenzana
E R
ER
Baylor College of Dentistry, Texas A and M University System, Dallas 75266-0677, USA.
Rees
T D
TD
Glass
M
M
Detweiler
J G
JG
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000032:analysis; D001623:Betamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D002908:Chronic Disease; D004848:Epithelium / Q000276:immunology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D005891:Gingivitis / Q000175:diagnosis; D005892:Gingivitis, Necrotizing Ulcerative / Q000175:diagnosis*; D005938:Glucocorticoids; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008875:Middle Aged; D014987:Xerostomia / Q000175:diagnosis
D000893:Anti-Inflammatory Agents; D000974:Antibodies, Antinuclear; D005938:Glucocorticoids; D007074:Immunoglobulin G; C011175:betamethasone-17,21-dipropionate; D001623:Betamethasone