Planar polarity: out of joint?
Epithelial structures, such as the wing hairs and ommatidia in Drosophila, are aligned in the plane of the epithelium. This planar polarity requires the transmembrane receptor Frizzled. Recent studies have shed new light on mechanisms that could be involved in generating or transducing the polarity signal.
Bray
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Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK. sjb32@mole.bio.cam.ac.uk.
D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D016764:Cell Polarity / Q000502:physiology*; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D015398:Signal Transduction
C498477:CELSR2 protein, human; D015820:Cadherins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C095900:fj protein, Drosophila; C058784:fz protein, Drosophila