No changes in dopamine D(1) receptor mRNA expressing neurons in the dorsal striatum of rats with oral movements induced by long-term haloperidol administration.
Neuroleptic-induced vacuous chewing movements (VCM) in rats, a putative analogue to tardive dyskinesia in man, may involve degeneration within striatum as well as changes in neurotransmitter and receptor expression. In this study, we measured the expression of dopamine D(1) receptor mRNA by dorsal striatal neurons in rats with high and low level of VCM after treatment with haloperidol for 38 weeks. Both the average integrated density of the in situ hybridization signal and number of cells obtained by the stereological cell counting remained within control level, irrespective of the level of haloperidol-induced oral dyskinesia.
Petersen
R
R
Department of Anatomy, Institute of Medical Biology, University of Odense, Odense, Denmark.
Finsen
B
B
Andreassen
O A
OA
Zimmer
J
J
Jørgensen
H A
HA
D000818:Animals; D002452:Cell Count; D018492:Dopamine Antagonists / Q000009:adverse effects*; D004334:Drug Administration Schedule; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D006220:Haloperidol / Q000009:adverse effects*; D008409:Mastication / Q000187:drug effects* / Q000502:physiology*; D017072:Neostriatum / Q000166:cytology / Q000187:drug effects* / Q000503:physiopathology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects* / Q000235:genetics*
D018492:Dopamine Antagonists; D012333:RNA, Messenger; D017447:Receptors, Dopamine D1; D006220:Haloperidol