title: Two cases of osteosarcoma occurring as second malignancy of childhood cancer.
abstract: We report on two patients in whom osteosarcoma occurred as second malignancy of childhood cancer. One patient had a malignant teratoma and the other adrenocortical carcinoma as the primary cancer. The emergence of cancer in cured cases and long-term survival cases of childhood cancer may result in an increase in the number of osteosarcomas seen in adolescence occurring as second malignancy. Anti-cancer drugs in large does were used for the treatment of a malignant teratoma in the former. These anti-cancer drugs may be involved in the occurrence of the second malignancy. In the latter, the patient has the germ-line mutation of p53 tumor suppressor gene, so genetic factors are presumably related to the occurrence of the second malignancy.
authors.affiliation: Division of Orthopaedic Surgery, Chiba Cancer Center, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yonemoto
authors.forename: S
authors.initials: S
authors.lastname: Tatezaki
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Inoue
mesh_terms: D000293:Adolescent; D000306:Adrenal Cortex Neoplasms; D018268:Adrenocortical Carcinoma; D002081:Buttocks; D002648:Child; D005260:Female; D005269:Femur; D006801:Humans; D016609:Neoplasms, Second Primary; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000556:secondary*; D011859:Radiography; D013724:Teratoma; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53