Cellular signaling with nitric oxide and cyclic guanosine monophosphate.
The understanding of the formation and biological actions of nitric oxide (NO) has grown extensively during the past two decades. With the discoveries of the biological effects of NO and nitrovasodilators on cyclic guanosine monophosphate, with the elucidation of the biochemical mechanisms of NO synthesis, and with the growing knowledge of regulation of NO synthases, the complexities of this signal transduction cascade and its participation in numerous cell signaling processes continues. NO can be recognized as an intracellular second messenger, a local substance for regulation of neighboring cells, a neurotransmitter, and probably a hormone acting at distant sites.
Martin
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E
Department of Integrative Biology, Pharmacology, University of Texas Health Science Center, Houston 77030, USA.
Davis
K
K
Bian
K
K
Lee
Y C
YC
Murad
F
F
D000818:Animals; D006152:Cyclic GMP / Q000378:metabolism / Q000502:physiology*; D005057:Eukaryotic Cells / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D009569:Nitric Oxide; D006152:Cyclic GMP