Effect of insulin-like growth factor-1 (IGF-1) on muscle and bone growth in experimental models.
The effect of protein restriction on the growth of muscle, bone and body tissue of rats fed a diet containing 5% protein (experimental group) and 12% protein (control group) was studied. The following parameters were analyzed: body, muscle and cartilage growth, tibial length, plasma insulin IGF-1 concentrations, and tissue proteoglycan, protein, RNA and insulin-like growth factor-1 concentrations. Protein synthesis in tissues was also determined. Except for protein concentration in the two tissues and of insulin-like growth factor-1 in cartilage, all other values differed significantly between groups. The lower ration and protein ingestion by group 1 receiving a 5% case in diet provoked a reduced secretion of the anabolic hormones insulin and IGF-1 and a lower synthesis of proteoglycans, RNA and protein, impairing total body growth and growth of the tissues analyzed.
Tirapegui
J
J
Department of Food Science and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil.
D000818:Animals; D001835:Body Weight / Q000502:physiology; D001846:Bone Development / Q000187:drug effects / Q000502:physiology*; D002356:Cartilage / Q000737:chemistry / Q000378:metabolism; D002364:Caseins / Q000008:administration & dosage; D004435:Eating / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D009132:Muscles / Q000187:drug effects; D011488:Protein Deficiency / Q000503:physiopathology; D011506:Proteins / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D002364:Caseins; D011506:Proteins; D007334:Insulin-Like Growth Factor I