title: Acute encephalopathy due to aluminum toxicity successfully treated by combined intravenous deferoxamine and hemodialysis.
abstract: Acute aluminum intoxication is uncommon in clinical practice but can be fatal. This limited experience is reflected in the paucity of data assessing a viable approach to the treatment of these patients. In this report, the authors describe the clinical course and successful, pharmacokinetic-based deferoxamine-hemodialysis treatment regimen of a patient with severe aluminum encephalopathy following alum bladder irrigation. The combined use of deferoxamine and appropriately timed hemodialysis appears to be a very reasonable means of treating patients with severe acute aluminum intoxication.
authors.affiliation: Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children's Hospital, Cleveland, OH 44106-6010, USA.
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: P G
authors.initials: PG
authors.lastname: Rose
authors.forename: J L
authors.initials: JL
authors.lastname: Blumer
authors.forename: M D
authors.initials: MD
authors.lastname: Reed
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000534:Alum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D003676:Deferoxamine / Q000008:administration & dosage / Q000627:therapeutic use*; D003693:Delirium / Q000139:chemically induced / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D006435:Renal Dialysis
chemical_list: D000534:Alum Compounds; C041524:aluminum sulfate; D003676:Deferoxamine