title: [Identification of 2 families with hereditary nonpolyposis colonic cancer (HNPCC) and the Amsterdam criteria. Relevance of the genealogic tree and follow-up].
abstract: Hereditary nonpolyposis colorectal cancer (HNPCC) diagnosis is based either on the so-called "Amsterdam 1 criteria" or "Amsterdam 2 criteria", which includes extracolonic neoplasms associated with Lynch II syndrome. Many families are suspected of having a hereditary predisposition to cancer and may benefit from close surveillance. We describe a family (family 1) with suspected HNPCC at the beginning who fulfilled the Amsterdam 1 criteria over the course of its follow-up. We also describe an Amsterdam 2 family (family 2) with a very young affected individual. Both of them received genetic counseling and screening recommendations. A total colonoscopy was done to an asymptomatic member of family 1 and he was diagnosed with an early-stage colon cancer. He underwent subtotal colectomy because of the high risk of metachronous lesion. Screening recommendations must be the same in Amsterdam 2 families as in Amsterdam 1. Both families show the importance of considering the family history when hereditary criteria are suspected.
authors.affiliation: Servei d'Oncologia Mèdica, Hospital de Sant Pau, Barcelona. jbalmana@hsp.santpau.es
authors.forename: J
authors.initials: J
authors.lastname: Balmaña
authors.forename: J
authors.initials: J
authors.lastname: Brunet
authors.forename: G
authors.initials: G
authors.lastname: Capellà
authors.forename: D
authors.initials: D
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Palicio
authors.forename: F J
authors.initials: FJ
authors.lastname: Sancho
authors.forename: C
authors.initials: C
authors.lastname: Pericay
authors.forename: J J
authors.initials: JJ
authors.lastname: López López
authors.forename: E
authors.initials: E
authors.lastname: Marcuello
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000556:secondary / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D003082:Colectomy; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D003113:Colonoscopy; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005817:Genetic Counseling; D005820:Genetic Testing; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013997:Time Factors