Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts.
The aim of the present study is comparison of changes of principal hemorheological factors responsible for blood flow disorders in the microcirculation in patients with ischemic brain infarcts. It was found that in venous blood samples the erythrocyte aggregability (examined with a direct, highly sensitive, quantitative technique) was considerably more increased (by mean of 120%) than the blood plasma fibrinogen contents, blood plasma viscosity, and hematocrit which increased only by 23.7%, 7.4% and 3.6%, respectively, as compared to the same hemorheological factors in the healthy controls. These results led us to the following conclusion: among the other tests the enhanced erythrocyte aggregability, when measured with an appropriate technique, is the best diagnostic indicator of hemorheological derangements during development of the ischemic brain infarct.
Mchedlishvili
G
G
Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia.
Shakarishvili
R
R
Momtselidze
N
N
Gobejishvili
L
L
Aloeva
M
M
Mantskava
M
M
D000328:Adult; D000368:Aged; D001809:Blood Viscosity; D020520:Brain Infarction / Q000097:blood*; D004903:Erythrocyte Aggregation / Q000502:physiology*; D004907:Erythrocyte Deformability; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood
D005340:Fibrinogen