Sleep in subjects with autistic disorder: a neurophysiological and psychological study.
Polysomnography (EOG, EEG, EMG) was carried out in 17 male children and adolescents with autistic disorder, in seven patients with mental retardation and fragile X syndrome, and in five age- and sex-matched normal male subjects. Density of rapid eye movements was not significantly different in the three groups of subjects; however, some sleep parameters such as time in bed, sleep period time, and total sleep time were significantly lower in subjects with autistic disorder than in normal controls; moreover, patients with autistic disorder showed values of sleep period time, first REM latency and percent (%) sleep stage 1 lower than those of patients with fragile X syndrome with mental retardation. Density of muscle twitches was significantly higher in patients with autistic disorder than in normal controls. In contrast only minor differences were observed between patients with autistic disorder and those with fragile X syndrome with mental retardation. Furthermore, some psychoeducational profile-revised items such as perception and eye-hand coordination, showed significant correlation with some sleep parameters (time in bed, sleep latency, stage shifts, first REM latency and wakefulness after sleep onset). Childhood Autism Rating Scale (CARS) scores to visual response and non-verbal communication showed significant correlation with some tonic sleep parameters, such as sleep period time, wakefulness after sleep onset, and total sleep time. Relating to people and activity level items were found to be significantly correlated with rapid eye movement density. Our results suggest the existence of a sleep pattern in autistic patients different from that observed in subjects with mental retardation and from that of normal controls. In addition, these findings indicate that sleep parameters in these patients are correlated with some psychological indices generally used for the diagnosis of autistic disorder; for this reason, polysomnographies might be useful in the comprehension of the neurophysiological mechanisms underlying this condition.
Elia
M
M
Department of Neurology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Via Conte Ruggero 73, 94018, Troina, Italy. melia@oasi.en.it
Ferri
R
R
Musumeci
S A
SA
Del Gracco
S
S
Bottitta
M
M
Scuderi
C
C
Miano
G
G
Panerai
S
S
Bertrand
T
T
Grubar
J C
JC
D000293:Adolescent; D001321:Autistic Disorder / Q000503:physiopathology* / Q000523:psychology*; D001921:Brain / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005600:Fragile X Syndrome / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D008607:Intellectual Disability / Q000503:physiopathology / Q000523:psychology; D008297:Male; D012890:Sleep / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology