title: Surgery: independent prognostic factor in curable and far advanced gastric cancer.
abstract: The hospital records of 639 patients affected by primary gastric cancer who were consecutively admitted to our unit during the period 1981-1995 were reviewed. Overall 220 underwent total gastrectomy (38 palliative), 12 had resection of the gastric stump, 195 had distal subtotal gastrectomy (55 palliative), 78 had bypass procedures, 72 had explorative laparotomy, and 62 had no operation. Univariate and multivariate analyses were used to evaluate 5-year survival with respect to the main clinical, pathologic, and treatment variables after both curative and palliative treatments. Overall the 5-year survival after curative treatment (320 patients-operative mortality excluded) was 55.5%: 91.1% for stage IA, 71.5% IB, 62.4% II, 37.5% IIIA, 31.5% IIIB. Among patients who underwent palliative treatment 5-year survival was 13.1% after gastric resection (total or distal subtotal), 4.9% after the bypass procedures, 0 after explorative laparotomy, and 0 after no operation. Univariate and multivariate survival analyses showed that variables independently associated with poor survival were advanced stage, upper location and D1 lymphadenectomy after curative treatment, tumor spread to distant sites, and nonresectional surgery after palliative treatment. Multivariate analysis showed that even though survival with gastric cancer depends on predetermined factors, the type of surgery can have a significant effect on prognosis after both curative and palliative treatment.
authors.affiliation: Department of Digestive Surgery, School of Medicine, Catholic University, Largo A. Gemelli n. 8, 00168 Rome, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Doglietto
authors.forename: F
authors.initials: F
authors.lastname: Pacelli
authors.forename: P
authors.initials: P
authors.lastname: Caprino
authors.forename: A
authors.initials: A
authors.lastname: Sgadari
authors.forename: F
authors.initials: F
authors.lastname: Crucitti
mesh_terms: D000704:Analysis of Variance; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000145:classification; D015390:Gastric Bypass; D018530:Gastric Stump / Q000601:surgery; D006801:Humans; D007813:Laparotomy; D015993:Life Tables; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D010166:Palliative Care; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome