title: alpha(2) Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-Imidazo)-1,3-dimethyl-6,7-dihydrothianaphthene [corrected] as a high-affinity ligand for the alpha(2D) adrenergic receptor.
authors.affiliation: Drug Discovery Division, The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Ross
authors.forename: M C
authors.initials: MC
authors.lastname: Jetter
authors.forename: M E
authors.initials: ME
authors.lastname: McDonnell
authors.forename: R E
authors.initials: RE
authors.lastname: Boyd
authors.forename: C D
authors.initials: CD
authors.lastname: Connelly
authors.forename: R P
authors.initials: RP
authors.lastname: Martinez
authors.forename: M A
authors.initials: MA
authors.lastname: Lewis
authors.forename: E E
authors.initials: EE
authors.lastname: Codd
authors.forename: R B
authors.initials: RB
authors.lastname: Raffa
authors.forename: A B
authors.initials: AB
authors.lastname: Reitz
mesh_terms: D000284:Administration, Oral; D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001667:Binding, Competitive; D002460:Cell Line; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D018712:Analgesics, Non-Narcotic; D007093:Imidazoles; D018341:Receptors, Adrenergic, alpha-2; D013876:Thiophenes