Heterotrimeric G proteins in heart disease.
Guanine nucleotide binding proteins (G proteins) are largely grouped into three classes: heterotrimeric G proteins, ras-like or small molecular weight GTP binding proteins, and others like Gh. In the heart G proteins transduce signals from a variety of membrane receptors to generate diverse effects on contractility, heart rate, and myocyte growth. This central position of G proteins forming a switchboard between extracellular signals and intracellular effectors makes them candidates possibly involved in the pathogenesis of cardiac hypertrophy, heart failure, and arrhythmia. This review focuses primarily on discoveries of heterotrimeric G protein alterations in heart diseases that help us to understand the pathogenesis and pathophysiology. We also discuss the underlying molecular mechanisms of heterotrimeric G protein signalling.
Zolk
O
O
Klinik III für Innere Medizin, Universität zu Köln, Germany.
Kouchi
I
I
Schnabel
P
P
Böhm
M
M
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism; D006332:Cardiomegaly / Q000378:metabolism; D006331:Heart Diseases / Q000209:etiology / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D017202:Myocardial Ischemia / Q000378:metabolism; D015398:Signal Transduction
D020962:Heterotrimeric GTP-Binding Proteins