Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodeling.
Pc-G and trx-G genes are responsible for maintenance of transcriptional regulation and provide a cellular memory mechanism throughout development. Studies in fly, yeast, mouse, and human have implicated modulation of higher-order chromatin structure as an important component in this process. Specifically, connections between SWI/SNF complexes and trx-G genes have provided a mechanistic link between chromatin remodeling and transcriptional regulation. Here we discuss recent genetic and biochemical data that has shed light on the molecular mechanisms and pathways associated with Pc-G and trx-G function in developmental processes such as cell cycle control and hematopoiesis. genesis 26:189-197, 2000.
Gebuhr
T C
TC
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Bultman
S J
SJ
Magnuson
T
T
D000818:Animals; D002843:Chromatin / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D019476:Insect Proteins / Q000235:genetics*; D063150:Polycomb Repressive Complex 1; D014157:Transcription Factors / Q000235:genetics*
D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; C066770:Pc protein, Drosophila; D014157:Transcription Factors; C063460:Trl protein, Drosophila; D063150:Polycomb Repressive Complex 1