[Effects of sandostatin on gastric mucosal perfusion in rats with portal hypertensive gastropathy].
OBJECTIVE
To observe the effects of sandostatin on gastric mucosal blood flow (GMBF) in rats with (portal hypertensive gastropathy, PHG) and its mechanisms.


METHODS
Two weeks after portal vein ligation, the changes of systemic hemodynamics, GMBF, (portal vein pressure, PVP) were observed and plasma glucagon, plasma and gastric mucosal NO2-/NO3-, 6-Keto-PGF(1alpha) were measured after intravenous sandostatin, propranolol and normal saline.


RESULTS
GMBF and PVP were reduced after intravenous sandostatin or propranolol. Sandostatin decreased plasma glucagon, plasma and gastric mucosal NO2-/NO3-, and had no effect on MAP and heart rate of PHG rats as compared with control group of PHG. Propranolol had not these effects, but it might decrease MAP and heart rate. There were no differences of plasma and gastric mucosal 6-Keto-PGF(1alpha) between all PHG groups.


CONCLUSIONS
Sandostatin reduced GMBF of rats with PHG by hindering glucagon, NO, and had no effect on systemic hemodynamics.
Le
Q
Q
Department of Gastroenterolgy, Fuzhou General Hospital, Fuzhou 350025, China.
Zhang
X
X
Zhang
J
J
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005934:Glucagon / Q000097:blood; D006975:Hypertension, Portal / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000096:biosynthesis; D015282:Octreotide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects
D005765:Gastrointestinal Agents; D009569:Nitric Oxide; D015121:6-Ketoprostaglandin F1 alpha; D005934:Glucagon; D015282:Octreotide