title: Conservative treatment of childhood phimosis with topical conjugated equine estrogen ointment.
abstract: OBJECTIVE
  To assess the application of topical conjugated equine estrogen for the treatment of boys with phimosis.
  
  
  METHODS
  Fifteen boys with phimosis were included in the study. Conjugated equine estrogen (Premarin) 0.1% ointment was applied on the prepuce once daily. The treatment was continued until the prepuce was fully retractable. The patient was examined each second week up to a maximum treatment of 8 weeks. Retractability and the appearance of the foreskin were graded before and after treatment.
  
  
  RESULTS
  Thirteen of 15 boys (87%) referred with phimosis were successfully treated with conjugated equine estrogen ointment. An adverse effect of gynecomastia was seen in one boy (7%).
  
  
  CONCLUSIONS
  Conjugated equine estrogen ointment application for phimosis may be an alternative to surgery.
authors.affiliation: Department of Urology, St Marianna University School of Medicine, Kanagawa, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: K
authors.initials: K
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Yamagoe
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
mesh_terms: D000287:Administration, Topical; D002648:Child; D002675:Child, Preschool; D004966:Estrogens, Conjugated (USP) / Q000009:adverse effects / Q000627:therapeutic use*; D006177:Gynecomastia / Q000139:chemically induced; D006801:Humans; D008297:Male; D009824:Ointments; D010688:Phimosis / Q000188:drug therapy*
chemical_list: D004966:Estrogens, Conjugated (USP); D009824:Ointments