Genes, receptors, signals and responses to lipopolysaccharide endotoxin.
C3H/HeJ inbred mice have been very useful for identifying genetic elements responsible for endotoxin mediated responses. Depending on the type of assays employed, Tlr-2, Tlr-4 and Lps/Ran have been shown to be important in lipopolysaccharide (LPS)-mediated responses. The concept of a single LPS gene being responsible for the genetic defect found in C3H/HeJ mice should therefore be re-examined more closely. Given the most recent discoveries, it is probable that more than one signal transduction pathway is involved. One is a CD14-dependent pathway, the other a CD14-independent pathway. Identification of the genetic elements involved in these pathways will be beneficial in designing therapeutic strategies for treating patients with endotoxic or septic shock.
Wong
P M
PM
Department of Pathology and Laboratory Medicine, Fels Institute, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Chugn
S W
SW
Sultzer
B M
BM
D000818:Animals; D019446:Endotoxemia / Q000235:genetics*; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D015398:Signal Transduction / Q000502:physiology; D020931:ran GTP-Binding Protein / Q000378:metabolism
D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D020931:ran GTP-Binding Protein