Pre-training blocks the improving effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation performance in aged rats.
We investigated the effect of pre-training on the improvement of spatial navigation performance provided by a cholinesterase inhibitor, tetrahydroaminoacridine (3 mg/kg, i.p.), and a positive modulator of NMDA receptor, D-cycloserine (10 mg/kg, i.p.), or their combination in aged rats. Pre-training consisted of spatial or non-spatial conditions and took place in either the same or a separate room. We found that any kind of pre-training was able to eliminate the enhancing effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation. However, none of these pre-training conditions was able to block the age-related deficit in spatial navigation. These results indicate that tetrahydroaminoacridine and D-cycloserine, separately or in combination, do not themselves alleviate the age-related spatial memory deficit, but may enhance procedural aspects of water maze learning in aged rats.
Aura
J
J
Department of Neuroscience and Neurology, University of Kuopio and Kuopio University Hospital, P.O. Box 1627, FIN-70211, Kuopio, Finland. aura@messi.uku.fi
Riekkinen
P
P
D000375:Aging / Q000502:physiology*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000502:physiology*; D003523:Cycloserine / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D011597:Psychomotor Performance / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013037:Spatial Behavior / Q000187:drug effects* / Q000502:physiology; D013550:Swimming; D013619:Tacrine / Q000494:pharmacology*; D014796:Visual Perception / Q000187:drug effects / Q000502:physiology
D002800:Cholinesterase Inhibitors; D013619:Tacrine; D003523:Cycloserine