Estimating in vitro glass fiber dissolution rate from composition.
A method is presented for calculating the dissolution rate constant of a borosilicate glass fiber in the lung, as measured in vitro, from the oxide composition in weight percent. It is based upon expressing the logarithm of the dissolution rate as a linear function of the composition. It was found that the calculated dissolution rate constant agreed with the measured value within the variation of the measured data in a set of compositions in which the dissolution rate constant ranged over a factor of 100. The method was shown to provide a reasonable estimate of dissolution over a considerably wider range of composition than what was used to determine the parameters, such as a set of data in which the dissolution rate constant varied over a factor of 100,000. The dissolution rate constant may be used to estimate whether disease would ensue following animal inhalation or intraperitoneal studies.
Eastes
W
W
Owens Corning, Science and Technology Center, 2790 Columbus Road, Route 16, Granville, OH 43023-1200, USA. walter.eastes@owenscorning. com
Potter
R M
RM
Hadley
J G
JG
D000818:Animals; D005898:Glass / Q000032:analysis / Q000737:chemistry*; D066298:In Vitro Techniques; D019570:Inhalation Exposure; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000139:chemically induced; D008956:Models, Chemical; D010087:Oxides / Q000032:analysis; D051381:Rats; D012995:Solubility
D010087:Oxides