Morphology of the designed biodegradable cisplatin microsphere.
We observed the morphological changes in microspheres containing cisplatin (CDDP) embedded in poly-d,l,-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS). The in vitro release of CDDP from CDDP-PPMS continued for more than four weeks. Scanning electron microscopy revealed that though the particles of CDDP-PPMS were spherical and superficially smooth, small pores with a superficial irregularity appeared six months later. CDDP-PPMS particles were found in the stomata of the omentum after intraperitoneal administration. When CDDP-PPMS was administered after Yoshida sarcoma cells were intraperitoneally transplanted, CDDP-PPMS was observed histologically in the necrotic tissues of the omentum. These experimental results confirmed the release of CDDP from CDDP-PPMS and the histological efficacy of CDDP-PPMS in the omentum against peritoneal metastasis.
Natsugoe
S
S
First Department of Surgery, Kagoshima University School of Medicine, Japan.
Tokuda
K
K
Shimada
M
M
Kumanohoso
T
T
Baba
M
M
Takao
S
S
Tabata
M
M
Nakamura
K
K
Yoshizawa
H
H
Aikou
T
T
D000818:Animals; D001672:Biocompatible Materials; D002945:Cisplatin / Q000008:administration & dosage*; D004337:Drug Carriers; D008297:Male; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009852:Omentum / Q000473:pathology; D051381:Rats
D001672:Biocompatible Materials; D004337:Drug Carriers; D002945:Cisplatin