Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome.
Human CC-chemokine receptor genes are known to be clustered. The detailed structure of this cluster was established by radiation hybrid mapping, and organization of BAC contigs by fluorescence hybridization on combed genomic DNA. A main cluster of six genes (CCR1, CCR3, CCRL2, CCR5, CCR2 and CCXCR1), covered by four BACs, was mapped to the 3p21.3 region of the human genome. Five other genes (CCR9, CCBP2, CX3CR1, CCR8 and CCR4) were found to be spread over a relatively large region between this main cluster and the 3p telomere.
Maho
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A
IRIBHN, Université Libre de Bruxelles, Campus Erasme, Brussels, Belgium.
Bensimon
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A
Vassart
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G
Parmentier
M
M
D000073883:CX3C Chemokine Receptor 1; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D020451:Contig Mapping; D005453:Fluorescence; D015698:Genomic Library; D006801:Humans; D006822:Hybrid Cells; D008126:Lod Score; D008565:Membrane Proteins; D005810:Multigene Family / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010454:Peptide Termination Factors / Q000235:genetics*; D020161:Physical Chromosome Mapping; D016133:Polymerase Chain Reaction; D054388:Receptors, CCR; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface / Q000235:genetics; D019707:Receptors, Chemokine / Q000235:genetics*; D018121:Receptors, Cytokine / Q000235:genetics; D043562:Receptors, G-Protein-Coupled; D015728:Receptors, HIV / Q000235:genetics; D000097628:Chemokine Receptor D6
D000073883:CX3C Chemokine Receptor 1; D008565:Membrane Proteins; D010454:Peptide Termination Factors; D054388:Receptors, CCR; D054447:Receptors, CCR10; D011956:Receptors, Cell Surface; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine; D043562:Receptors, G-Protein-Coupled; D015728:Receptors, HIV; D000097628:Chemokine Receptor D6; C119309:CC chemokine receptor 9; C489002:ETF1 protein, human; C091671:XCR1 protein, human