Lymphatic transport of proteins after subcutaneous administration.
This mini-review summarizes the relevant literature regarding the lymphatic transport of proteins after subcutaneous administration. A review of the physiology of the lymphatics and inherent anatomical differences between blood and lymph capillaries is presented followed by a brief overview of the general characteristics of protein absorption and bioavailability following S.C. injection. A description of factors known to directly affect the lymphatic uptake of macromolecules follows and is supported by representative data from this laboratory. A brief perspective on the importance of lymphatic uptake and transport in understanding the biopharmaceutical properties of protein drugs and potentially targeting the lymphatics is presented.
Porter
C J
CJ
Department of Pharmaceutics, Victorian College of Pharmacy Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia.
Charman
S A
SA
D000818:Animals; D001692:Biological Transport; D006801:Humans; D007279:Injections, Subcutaneous; D008208:Lymphatic System / Q000378:metabolism*; D011506:Proteins / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics
D011506:Proteins