title: Effect of atypical antipsychotics on phencyclidine-induced expression of arc in rat brain.
abstract: The effect of atypical antipsychotics on the immediate-early gene, arc (activity-regulated cytoskeleton-associated gene), expression was investigated in phencyclidine (PCP)-treated rats using RT-PCR. Administration of PCP (10 mg/kg) increased arc mRNA levels in the prefrontal cortex, nucleus accumbens and posterior cingulate cortex. Pretreatment with clozapine (20 mg/kg), olanzapine (10 mg/kg) and risperidone (2 mg/kg), but not haloperidol (2 mg/kg), prevented PCP-induced arc expression in the prefrontal cortex and nucleus accumbens. Pretreatment of haloperidol increased the striatal arc mRNA levels. Clozapine, olanzapine and haloperidol inhibited the PCP-induced arc expression in the posterior cingulate cortex. These results suggest that the effects of antipsychotic drugs on PCP-induced arc expression in the prefrontal cortex and nucleus accumbens are useful for distinguishing atypical antipsychotic properties of the drugs.
authors.affiliation: Department of Chemistry, Faculty of Science, Kyushu University, Ropponmatasu, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakahara
authors.forename: T
authors.initials: T
authors.lastname: Kuroki
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Hondo
authors.forename: T
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: K
authors.initials: K
authors.lastname: Motomura
authors.forename: H
authors.initials: H
authors.lastname: Ueki
authors.forename: M
authors.initials: M
authors.lastname: Hirano
authors.forename: H
authors.initials: H
authors.lastname: Uchimura
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D003024:Clozapine / Q000494:pharmacology; D003598:Cytoskeletal Proteins / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D000077152:Olanzapine; D010622:Phencyclidine / Q000494:pharmacology*; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018967:Risperidone / Q000494:pharmacology; D014018:Tissue Distribution
chemical_list: D014150:Antipsychotic Agents; D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C092069:activity regulated cytoskeletal-associated protein; D001569:Benzodiazepines; D010890:Pirenzepine; D010622:Phencyclidine; D003024:Clozapine; D006220:Haloperidol; D018967:Risperidone; D000077152:Olanzapine