Campylobacter jejuni lipopolysaccharides from Guillain-Barré syndrome patients induce IgG anti-GM1 antibodies in rabbits.
Lipopolysaccharides (LPS) from Campylobacter jejuni strains isolated from patients with Guillain-Barré syndrome (GBS) display molecular mimicry with GM1. We immunized rabbits with C. jejuni LPS from GBS-associated strains containing a GM1-like epitope. All animals produced high titre anti-LPS antibodies that were cross-reactive with GM1. We conclude that C. jejuni strains from GBS patients are able to induce antibodies that cross-react with gangliosides and LPS. This study further confirms the role of molecular mimicry in the induction of anti-ganglioside antibodies in GBS patients.
Ang
C W
CW
Department of Neurology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands.
Endtz
H P
HP
Jacobs
B C
BC
Laman
J D
JD
de Klerk
M A
MA
van der Meché
F G
FG
van Doorn
P A
PA
D000818:Animals; D000906:Antibodies / Q000097:blood*; D000917:Antibody Formation; D016123:Campylobacter jejuni; D004195:Disease Models, Animal; D000939:Epitopes; D005677:G(M1) Ganglioside / Q000276:immunology*; D005678:G(M2) Ganglioside / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D000906:Antibodies; D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D005678:G(M2) Ganglioside; D005677:G(M1) Ganglioside