Regulation of signal transduction by endocytosis.
Endocytosis of ligand-activated receptors has generally been considered a mechanism to attenuate signaling. There is now a growing body of evidence suggesting that this process is much more sophisticated and that endocytic membrane trafficking regulates both the intensity of signaling and the co-localization of activated receptors with downstream signaling molecules.
Ceresa
B P
BP
Department of Cell Biology, IMM-11, The Scripps Research Institute, La Jolla, CA 92037, USA.
Schmid
S L
SL
D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
D018719:Erb-b2 Receptor Tyrosine Kinases