title: [The permeability of the hemato-encephalic barrier and the proteolytic potential of the cerebrospinal fluid in severe craniocerebral trauma].
abstract: To study blood-brain barrier permeability and proteolytic changes in in patients with severe brain injury and to evaluate their impact on its course and outcome, the concentrations of albumin, plasminogen (plasmin), alpha 2-macroglobulin, alpha 2-antiplasmin, and alpha 1-antitrypsin were examined in 58 victims by enzyme immunoassay. The control group comprised 20 patients examined for lumbar discal hernia. The studies indicate that early severe brain injury showed blood-brain barrier dysfunction whose severity can be detected by the spinal fluid levels of albumin, plasminogen, and alpha 2-macroglobulin. Proteolytic changes in spinal fluid are determined by its albumin, plasminogen (plasmin), alpha 2-macroglobulin, alpha 2-antiplasmin, and alpha 1-antitrypsin concentrations and affect the development of secondary brain lesion and they are of practical value.
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Churliaev
authors.forename: N V
authors.initials: NV
authors.lastname: Nikiforova
authors.forename: A A
authors.initials: AA
authors.lastname: Lutsik
authors.forename: V A
authors.initials: VA
authors.lastname: Kuksinskiĭ
authors.forename: O F
authors.initials: OF
authors.lastname: Lykova
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Martynenkov
authors.forename: V S
authors.initials: VS
authors.lastname: Karpenko
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001812:Blood-Brain Barrier / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000502:physiology*; D006259:Craniocerebral Trauma / Q000134:cerebrospinal fluid* / Q000503:physiopathology*; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000134:cerebrospinal fluid / Q000503:physiopathology; D008159:Lumbar Vertebrae; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000134:cerebrospinal fluid*; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D015599:Trauma Severity Indices
chemical_list: D010447:Peptide Hydrolases