title: Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria.
abstract: The development of effective malaria vaccines depends on the identification of targets of well-defined protective immune responses. Data and samples from a longitudinal study of a cohort of children from coastal Ghana were used to investigate the role of antibody responses to 3 regions of the Plasmodium falciparum glutamate-rich protein (GLURP). The data show that levels of the GLURP-specific IgG that occurs in the nonrepeat region of the antigen are significantly correlated with clinical protection from P. falciparum malaria, after correction for the confounding effect of age. Furthermore, levels of cytophilic antibodies were found to be of particular importance for protection, lending support to the hypothesis that antibody-dependent cellular inhibition is the important element in GLURP-specific protective immunity.
authors.affiliation: Immunology and Epidemiology Units, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
authors.forename: D
authors.initials: D
authors.lastname: Dodoo
authors.forename: M
authors.initials: M
authors.lastname: Theisen
authors.forename: J A
authors.initials: JA
authors.lastname: Kurtzhals
authors.forename: B D
authors.initials: BD
authors.lastname: Akanmori
authors.forename: K A
authors.initials: KA
authors.lastname: Koram
authors.forename: S
authors.initials: S
authors.lastname: Jepsen
authors.forename: F K
authors.initials: FK
authors.lastname: Nkrumah
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: L
authors.initials: L
authors.lastname: Hviid
mesh_terms: D000293:Adolescent; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D016778:Malaria, Falciparum / Q000517:prevention & control*; D008297:Male; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015800:Protozoan Proteins; D011994:Recombinant Proteins; C072492:glutamate-rich protein, Plasmodium