Cytokines and their receptors in cardiovascular diseases--role of gp130 signalling pathway in cardiac myocyte growth and maintenance.
Interleukin (IL)-6-related cytokines share gp130 as the signal-transducing protein. Cardiac myocytes produce various kinds of cytokines including IL-6 and cardiotrophin-1. Activation of gp130 transduces hypertrophic and cytoprotective signals in cardiac myocytes via JAK/STAT, MAP kinase and PI-3 kinase pathways. Besides various well-established mechanisms by which cardiac growth and myocardial remodeling are regulated, gp130 signalling may be a newly discovered mechanism that regulates these events in association with cytoprotective effect in myocardial diseases.
Yamauchi-Takihara
K
K
Department of Molecular Medicine, Osaka University Medical School, Osaka, Japan. takihara@imed3.med.osaka-u.ac.jp
Kishimoto
T
T
D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D016207:Cytokines / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D017978:Receptors, Growth Factor / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D015850:Interleukin-6; D017978:Receptors, Growth Factor