[Could apoptosis be contributed to the occurrence of aortic dissection?].
This clinical study was conducted to determine whether apoptosis is contributed to the occurrence of aortic dissection. The subjects comprised 11 patients who underwent Stanford type A aortic dissection and 4 autopsy cases, being the control group. The occurrence of apoptosis was determined by the TUNEL assay using an aortic wall specimen, and the distribution of macrophages and h-MMP-9 was examined by immunohistological staining. Apoptotic cells were observed in the aortic specimens for all of the 11 patients who underwent Standford type A aortic dissection, but not in any of the 4 autopsy cases. Moreover, apoptotic cells were present in large numbers on the surface of the false lumen strongly in 8 patients who underwent surgery within 1 month after aortic dissection, but not in 3 who underwent treatment after than 1 month. Those phenomena were also observed in the immunohistological staining of CD 68 and h-MMP-9. These findings indicate that apoptosis could be contributed to the occurrence of aortic dissection.
Shirasawa
B
B
First Department of Surgery, Yamaguchi University School of Medicine, Japan.
Hamano
K
K
Kobayashi
T
T
Kawamura
T
T
Gohra
H
H
Katoh
T
T
Fujimura
Y
Y
Zempo
N
N
Esato
K
K
D000368:Aged; D000784:Aortic Dissection / Q000209:etiology / Q000473:pathology*; D001011:Aorta / Q000166:cytology / Q000201:enzymology; D001014:Aortic Aneurysm / Q000209:etiology / Q000473:pathology*; D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D008875:Middle Aged
D015415:Biomarkers; D020780:Matrix Metalloproteinase 9