[Therapeutic efficacy of microsphere-entrapped curcuma aromatica oil infused via hepatic artery against transplanted hepatoma in rats].
OBJECTIVE
To observe the therapeutic efficacy of microsphere-entrapped Curcuma aromatica oil (MS-CAO) infused via hepatic artery against transplanted hepatoma in rats.


METHODS
One hundred duplicated rats bearing transplanted hepatoma were randomly divided into control group, CAO group, blank microsphere (B-MS) group, high-dose and low-dose MS-CAO groups. Each group included twenty rats. Normal saline (0.2-0.3 ml), CAO (10mg/kg), B-MS (10mg/kg) and MS-CAO (10mg/kg, 5mg/kg) were infused from gastroduodenal artery into hepatic artery, in five groups of rats respectively. The survival periods and the tumor growth rates and necrosis grades were compared in rats among five groups.


RESULTS
Compared with the control group of rats, the tumor growth rates were significantly inhibited (1.23% +/- 0.66%, 4.86% +/- 1.47% vs 22.44% +/- 17.81%, F=10.21, P<0.01), the tumor necrosis grades were more extensive (Hc=23.63, P<0.01) and the survival periods were also prolonged (25.50 d +/- 3.89 d, 22.70 d +/- 3.92 d vs 11.70 d +/- 1.89 d, F=36.53, P<0.01) in either high-dose or low-dose MS-CAO group. The therapeutic effects of MS-CAO were superior to either CAO or B-MS.


CONCLUSIONS
The therapeutic efficacy of MS-CAO infused via hepatic artery against hepatoma was much better than that of CAO or B-MS in the rats bearing transplanted hepatoma.
Wu
W
W
Department of Cancer, Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China.
Deng
R
R
Ou
Y
Y
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D006499:Hepatic Artery; D007261:Infusions, Intra-Arterial; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy*; D008297:Male; D008863:Microspheres; D009368:Neoplasm Transplantation; D051381:Rats; D017208:Rats, Wistar
D000972:Antineoplastic Agents, Phytogenic