Identification and analysis of a third mouse Polycomb gene, MPc3.
A new mouse Polycomb (Pc) gene, MPc3, has been identified. The MPc3 protein contains the highly conserved chromodomain and carboxy-terminal COOH box of other known Pc proteins from diverse species. Like other Pc proteins, MPc3 physically interacts with the RING finger proteins RING1A and dinG/RING1B. MPc3 maps to the distal arm of mouse chromosome 11 (11E2), a region that contains other known Pc genes in addition to several disease loci that may be linked to abnormal Pc gene function.
Hemenway
C S
CS
Department of Pediatrics, and the Tulane Cancer Center, University School of Medicine, New Orleans, LA 70112, USA. chemenw@tmcpop.tmc.tulane.edu
Halligan
B W
BW
Gould
G C
GC
Levy
L S
LS
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D004247:DNA / Q000737:chemistry / Q000235:genetics; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D004622:Embryo, Mammalian / Q000378:metabolism; D005091:Exons; D018507:Gene Expression Regulation, Developmental; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D051379:Mice; D008815:Mice, Inbred Strains; D033681:Mitochondrial Membrane Transport Proteins; D008969:Molecular Sequence Data; D063150:Polycomb Repressive Complex 1; D063146:Polycomb-Group Proteins; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D020798:Two-Hybrid System Techniques
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D033681:Mitochondrial Membrane Transport Proteins; D063146:Polycomb-Group Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins; D004247:DNA; C570429:Cbx8 protein, mouse; D063150:Polycomb Repressive Complex 1; C489840:Ring1 protein, mouse