title: Active steroidogenesis in the normal rat skin.
abstract: Using the radiolabeled precursors of adrenal steroids (14)C-11-deoxycorticosterone (DOC) and (14)C-progesterone ((14)C-PROG) we demonstrate that rat skin can synthesize a number of steroids. TLC separation of labeled metabolites show that among the (14)C-steroid products, two co-migrate with corticosterone (B) and 11-dehydrocorticosterone (A) standards. Thus, normal rodent skin possesses steroidogenic activity that can be shown using progesterone or DOC as primary substrates.
authors.affiliation: Department of Pathology, Medical Center, Loyola University, Maywood, IL 60153, USA. aslomin@wpo.it.luc.edu
authors.forename: A
authors.initials: A
authors.lastname: Slominski
authors.forename: C E
authors.initials: CE
authors.lastname: Gomez-Sanchez
authors.forename: M F
authors.initials: MF
authors.lastname: Foecking
authors.forename: J
authors.initials: J
authors.lastname: Wortsman
mesh_terms: D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D003345:Corticosterone / Q000096:biosynthesis; D003900:Desoxycorticosterone / Q000096:biosynthesis / Q000378:metabolism; D008297:Male; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D020303:Rats, Inbred Dahl; D012867:Skin / Q000378:metabolism*; D013256:Steroids / Q000096:biosynthesis*
chemical_list: D002250:Carbon Radioisotopes; D013256:Steroids; D003900:Desoxycorticosterone; D011374:Progesterone; D003345:Corticosterone