title: Bone-fracture incidence rate in two Italian regions with different fluoride concentration levels in drinking water.
abstract: The effect of the fluoride concentration in drinking water on the prevention of fractures related to osteoporosis has been questioned or contradicted in several recent studies. These studies have been mostly performed using water with artificially added fluoride, at the optimum level of about 1 mg/l. In the present study authors have investigated the effect of equal or greater fluoride concentrations (mean 1.45 mg/l) naturally present in waters supplied for human consumption to a population of 72.756 (Bracciano county), in comparison with a population of 126.189 (Avezzano county), supplied with low fluoride concentration water (mean 0.05 mg/l). The incidence of fractures in the years 1990 and 1991 was evaluated in the two areas (Bracciano and Avezzano), which are located in central Italy and where population have a similar life style, economic and social level and employment structure. The incidence data were obtained from the registers of the public hospital taken as a reference in each district. The authors noticed a significantly greater rate of fracture incidence at several parts of the body, in particular femur fractures (relative risks for males 4.28 and for females 2.64), in the population of the district of Avezzano than in the population of Bracciano. The greater concentration of fluoride in waters distributed for human consumption in Bracciano district seems to have the effect of protecting its inhabitants against fractures.
authors.affiliation: Dipartimento di Medicina interna e Sanità Pubblica Università degli studi dell'Aquila, Italia.
authors.forename: L
authors.initials: L
authors.lastname: Fabiani
authors.forename: V
authors.initials: V
authors.lastname: Leoni
authors.forename: M
authors.initials: M
authors.lastname: Vitali
mesh_terms: D005459:Fluorides / Q000032:analysis*; D050723:Fractures, Bone / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D014881:Water Supply / Q000032:analysis*
chemical_list: D005459:Fluorides