Effect of 7-methoxytacrine and L-carnitine on the activity of choline acetyltransferase.
Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 3-days treated with L-carnitine and then with one administration of 7-MEOTA. Both compounds increased ChAT activity when administered separately. 3-day treatment of CRT followed by administration of 7-MEOTA normalized ChAT activity.
Bajgar
J
J
Military Medical Academy, Hradec Králové, Czech Republic. bajgar@pmfhk.cz
Skopec
F
F
Herink
J
J
Patocka
J
J
Kvetina
J
J
D000818:Animals; D001479:Basal Ganglia / Q000201:enzymology*; D002331:Carnitine / Q000494:pharmacology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005260:Female; D006624:Hippocampus / Q000201:enzymology*; D007700:Kinetics; D009474:Neurons / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013619:Tacrine / Q000031:analogs & derivatives* / Q000494:pharmacology
D013619:Tacrine; C016222:7-methoxytacrine; D002795:Choline O-Acetyltransferase; D002331:Carnitine