title: [Proper usage of thiazolidinediones].
abstract: For the proper usage of thiazolidinedione, 5 preparations including troglitazone, pioglitazone and rosiglitazone in Japan and USA, the package insert of preparation were carefully reviewed from the point of view on indication of pathophysiology of Type 2 Diabetes Mellitus, mono or combined therapy and safety including hepatotoxicity, fluid accumulation. Careful reading of the package insert and patient leaflet, if any, is essential for the proper and safe usage of this important and prospective medicine. True usefulness waits for many long-term multi-center mega-size clinical trials.
authors.affiliation: University of Teikyo.
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D002839:Chromans / Q000008:administration & dosage / Q000009:adverse effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D007333:Insulin Resistance; D017114:Liver Failure, Acute / Q000139:chemically induced; D000077205:Pioglitazone; D000077154:Rosiglitazone; D013844:Thiazoles / Q000008:administration & dosage / Q000009:adverse effects; D045162:Thiazolidinediones; D000077288:Troglitazone
chemical_list: D002839:Chromans; D007004:Hypoglycemic Agents; D013844:Thiazoles; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D000077288:Troglitazone; D000077205:Pioglitazone