title: [Could apoptosis be contributed to the occurrence of aortic dissection?].
abstract: This clinical study was conducted to determine whether apoptosis is contributed to the occurrence of aortic dissection. The subjects comprised 11 patients who underwent Stanford type A aortic dissection and 4 autopsy cases, being the control group. The occurrence of apoptosis was determined by the TUNEL assay using an aortic wall specimen, and the distribution of macrophages and h-MMP-9 was examined by immunohistological staining. Apoptotic cells were observed in the aortic specimens for all of the 11 patients who underwent Standford type A aortic dissection, but not in any of the 4 autopsy cases. Moreover, apoptotic cells were present in large numbers on the surface of the false lumen strongly in 8 patients who underwent surgery within 1 month after aortic dissection, but not in 3 who underwent treatment after than 1 month. Those phenomena were also observed in the immunohistological staining of CD 68 and h-MMP-9. These findings indicate that apoptosis could be contributed to the occurrence of aortic dissection.
authors.affiliation: First Department of Surgery, Yamaguchi University School of Medicine, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Shirasawa
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Kawamura
authors.forename: H
authors.initials: H
authors.lastname: Gohra
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimura
authors.forename: N
authors.initials: N
authors.lastname: Zempo
authors.forename: K
authors.initials: K
authors.lastname: Esato
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000209:etiology / Q000473:pathology*; D001011:Aorta / Q000166:cytology / Q000201:enzymology; D001014:Aortic Aneurysm / Q000209:etiology / Q000473:pathology*; D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008264:Macrophages / Q000473:pathology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D020780:Matrix Metalloproteinase 9