title: Single inoculation of replication-defective adenovirus-vectored vaccines at birth in piglets with maternal antibodies induces high level of antibodies and protection against pseudorabies.
abstract: In neonates, one limitation of vaccination is its inhibition by maternal antibodies. We show that piglets vaccinated intramuscularly once at birth with recombinant replication-defective adenoviruses developed comparable neutralizing antibody response against pseudorabies virus, independently of the presence or absence of maternal antibodies, and were partially protected against challenge 16 weeks later.
authors.affiliation: Unite de Génétique Moléculaire, Génétique virale, INRA, Ecole Nationale Vétérinaire, 7 avenue du Général de Gaulle, 94704, Maisons Alfort, France.
authors.forename: M
authors.initials: M
authors.lastname: Monteil
authors.forename: M F
authors.initials: MF
authors.lastname: Le Pottier
authors.forename: A A
authors.initials: AA
authors.lastname: Ristov
authors.forename: R
authors.initials: R
authors.lastname: Cariolet
authors.forename: R
authors.initials: R
authors.lastname: L'Hospitalier
authors.forename: B
authors.initials: B
authors.lastname: Klonjkowski
authors.forename: M
authors.initials: M
authors.lastname: Eloit
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology*; D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D011558:Herpesvirus 1, Suid / Q000235:genetics; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007273:Injections, Intramuscular; D051379:Mice; D011557:Pseudorabies / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; C107752:glycoprotein D, pseudorabies virus; C070915:glycoprotein gII, pseudorabies virus; C042966:pseudorabies virus glycoproteins