title: Hypoglycemic activity of root water decoction, sesquiterpenoids, and one polysaccharide fraction from Psacalium decompositum in mice.
abstract: The hypoglycemic activity of Psacalium decompositum (Asteraceae) was investigated in fasting healthy mice and alloxan-diabetic mice. The freeze-dried water decoction significantly reduced the blood glucose in normal mice (from 50.9 +/- 4.7 to 32.5 +/- 3.1 mg/dl) and in mild diabetic mice (from 208.5 +/- 13.0 to 52.3 +/- 7.0 mg/dl), 240 min after intraperitoneal administration (P < 0.005). This preparation also diminished fasting glycemia in severe diabetic mice, but the effects were minor (from 394.4 +/- 9.4 to 289.3 +/- 39.5 mg/dl). The main sesquiterpenoid constituents from P. decompositum roots, cacalol, cacalone and maturin, as well as the transformation product cacalol acetate, did not show a hypoglycemic effect on healthy mice. Nevertheless, two polysaccharide fractions (F1 and F3) obtained from the freeze-dried water extract significantly reduced the fasting glycemia in healthy mice. The best results were obtained with the F1 fraction.
authors.affiliation: Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, México D.F., Mexico.
authors.forename: F J
authors.initials: FJ
authors.lastname: Alarcon-Aguilar
authors.forename: M
authors.initials: M
authors.lastname: Jimenez-Estrada
authors.forename: R
authors.initials: R
authors.lastname: Reyes-Chilpa
authors.forename: B
authors.initials: B
authors.lastname: Gonzalez-Paredes
authors.forename: C C
authors.initials: CC
authors.lastname: Contreras
authors.forename: R
authors.initials: R
authors.lastname: Roman-Ramos
mesh_terms: D000496:Alloxan; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D014867:Water
chemical_list: D007004:Hypoglycemic Agents; D011134:Polysaccharides; D012717:Sesquiterpenes; D014867:Water; D000496:Alloxan