Adenosine with cold blood cardioplegia during coronary revascularization.
OBJECTIVE
To investigate whether adenosine in association with blood cardioplegia results in more rapid cardiac arrest or improved myocardial protection.


METHODS
A prospective, randomized, placebo-controlled double-blind clinical study.


METHODS
Operative and intensive care units in a university hospital, Finland.


METHODS
Forty patients undergoing primary, elective coronary revascularization.


METHODS
Adenosine as a bolus dose, 12 mg intravenously, was given immediately before the induction of blood cardioplegia.


RESULTS
There were nonsignificantly higher serial serum values of CK (MB) (p = 0.33), troponin-T (p = 0.23), and troponin-I (p = 0.10) in the adenosine group. There were no differences between the groups in arrest time, blood pressure decrease, or lactate extraction.


CONCLUSIONS
The adenosine regimen used in this study did not cause more rapid arrest with blood cardioplegia. The effect on cardioprotection was insignificant.
Rinne
T
T
Department of Anaesthesia and Intensive Care, Tampere University Hospital, and Medical School, Finland.
Laurikka
J
J
Penttilä
I
I
Kaukinen
S
S
D000241:Adenosine / Q000008:administration & dosage*; D001769:Blood; D003080:Cold Temperature; D003402:Creatine Kinase / Q000097:blood; D004311:Double-Blind Method; D006324:Heart Arrest, Induced / Q000379:methods; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase; D000241:Adenosine