Study of solution equilibria between aluminum(III) ion and ofloxacin.
The complex formation equilibria between aluminium(III) ion and ofloxacin in 0.1 mol/l(-1) ionic medium at 298 K were studied by glass electrode pH-metric and UV spectrophotometric measurements. Within ofloxacin to aluminium mole ratio ranging from 2:1 to 25:1 and in pH interval from 2.5 to 10.5, the obtained experimental results were explained by the formation of the following complexes: AI(Hoflo) (log beta1,1,1 = 15.93 +/- 0.03), Al(oflo)2 (log beta1,2,0= 14.84 +/- 0.07), Al(oflo) (log beta1,1,0 = 10.20 +/- 0.04) as well as several other mixed and pure hydrolytic complexes. The structure and mechanism of the formation of the complexes and their possible implications on aluminum toxicity were discussed.
Djurdjevic
P T
PT
Faculty of Science, Kragujevac, Yugoslavia. preki@knez.uis.kg.ac.yu
Jelikic-Stankov
M
M
D000535:Aluminum / Q000737:chemistry*; D000838:Anions / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D015394:Molecular Structure; D015242:Ofloxacin / Q000737:chemistry*; D011199:Potentiometry; D011522:Protons; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D017186:Titrimetry
D000838:Anions; D008024:Ligands; D011522:Protons; D012996:Solutions; D015242:Ofloxacin; D000535:Aluminum