title: Magnetoencephalography in children with Landau-Kleffner syndrome and acquired epileptic aphasia.
abstract: OBJECTIVE
  Landau-Kleffner syndrome (LKS) is epileptiform aphasia acquired during childhood and occurring in children with previously normal language development. The epileptiform activity in these children is thought to result in a functional ablation of eloquent speech areas. The purpose of this study was to investigate the usefulness of magnetoencephalography (MEG) for localizing the source of epileptiform activity in these patients.
  
  
  METHODS
  Nineteen patients with acquired aphasia and a suspected diagnosis of LKS were referred for MEG evaluation. Patients ranged in age from 4 to 14 years. Fourteen MEG studies were performed on a 74-channel system, four on a 148-channel whole-head system, and one on a 37-channel system.
  
  
  RESULTS
  Thirteen of the 19 patients had perisylvian MEG spikes. In 10 of the patients, the spikes were bilateral, and in three they were unilateral. Four other patients had non-sylvian spikes, and two patients had no spikes recorded. The results of MR imaging were normal or noncontributory for all 19 patients.
  
  
  CONCLUSIONS
  MEG can play a useful role in evaluating children with LKS and acquired epileptiform aphasia, both in diagnosis and in aiding presurgical localization of epileptiform activity when surgery is being considered.
authors.affiliation: Division of Neuroradiology, Scripps Clinic, La Jolla, CA 92037, USA.
authors.forename: D F
authors.initials: DF
authors.lastname: Sobel
authors.forename: M
authors.initials: M
authors.lastname: Aung
authors.forename: H
authors.initials: H
authors.lastname: Otsubo
authors.forename: M C
authors.initials: MC
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D012815:Signal Processing, Computer-Assisted