title: Diuretic induced change in lung water assessed by electrical impedance tomography.
abstract: Monitoring patients with left ventricular failure can be difficult. Electrical impedance tomography (EIT) produces cross-sectional images of changes in the impedance of the thorax. We measured changes in the electrical impedance of the lung in nine volunteers following a diuretic challenge. The hypothesis was that lung impedance would increase with diuretic induced fluid loss. Heart rate, blood pressure and urine output were also recorded. After diuretic the mean urine output was 1220 ml compared with 187 ml after placebo. Following diuretic administration, mean thoracic impedance increased by 13.6% (p < 0.01) and lung impedance increased by 7.8% (p < 0.05). Taken as a group there was a correlation between overall impedance change and total urine output. However, for each individual, the time course of change in impedance and urine output did not correlate significantly. Our findings show that EIT may offer a better guide to the response of the lung to diuretic treatment than simply measuring urine output. The urine output is neither specific nor sensitive in the assessment of lung water. Mean lung impedance, however, is largely determined by lung water. The study showed that lung impedance can be recorded at supra-normal values. EIT may help in the management of patients with excess lung water.
authors.affiliation: Pulmonary Medicine, University of Sheffield, UK.
authors.forename: T J
authors.initials: TJ
authors.lastname: Noble
authors.forename: N D
authors.initials: ND
authors.lastname: Harris
authors.forename: A H
authors.initials: AH
authors.lastname: Morice
authors.forename: P
authors.initials: P
authors.lastname: Milnes
authors.forename: B H
authors.initials: BH
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D000328:Adult; D001834:Body Water / Q000187:drug effects* / Q000502:physiology*; D002034:Bumetanide / Q000494:pharmacology; D002307:Cardiography, Impedance / Q000379:methods*; D004231:Diuresis; D004232:Diuretics / Q000494:pharmacology*; D004311:Double-Blind Method; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D014054:Tomography / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D004232:Diuretics; D002034:Bumetanide