Antihyperglycemic acetylenic glucosides from Bidens pilosa.
In vivo bioassay-guided fractionation of the aqueous alcohol extract of the aerial parts of Bidens pilosa Sch. Bip. var. radiata (Asteraceae) using C57 BL/Ks-db/db mice as a model for type 2 diabetes, yielded two known polyacetylenic glucosides, identified as 2-beta-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-+ ++triyne (1) and 3-beta-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,1 2-triyne (2). A 3:2 mixture of compounds 1 and 2 effected a significant drop in blood glucose.
Ubillas
R P
RP
Mendez
C D
CD
Jolad
S D
SD
Luo
J
J
King
S R
SR
Carlson
T J
TJ
Fort
D M
DM
D000114:Acetylene / Q000737:chemistry; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D005960:Glucosides; D007004:Hypoglycemic Agents; D000114:Acetylene