title: Heart failure alters the strength and mechanisms of the muscle metaboreflex.
abstract: We hypothesized that excessive sympathoactivation observed during strenuous exercise in subjects with heart failure (HF) may result from tonic activation of the muscle metaboreflex (MMR) via hypoperfusion of active skeletal muscle. We studied MMR responses in dogs during treadmill exercise by graded reduction of terminal aortic blood flow (TAQ) before and after induction of HF by rapid ventricular pacing. At a low workload, in both control and HF experiments, large decreases in TAQ were required to elicit the MMR pressor response. During control experiments, this pressor response resulted from increased cardiac output (CO), whereas in HF CO did not increase; thus the pressor response was solely due to peripheral vasoconstriction. In HF, MMR activation also induced higher plasma levels of vasopressin, norepinephrine (NE), and renin. At a higher workload, in control experiments any reduction of TAQ elicited MMR pressor responses. In HF, before any vascular occlusion, TAQ was already below MMR control threshold levels and reductions in TAQ again did not result in higher CO; thus SAP increased via peripheral vasoconstriction. NE rose markedly, indicating intense sympathetic activation. We conclude that in HF, the MMR is likely tonically active at moderate workloads and contributes to the tonic sympathoactivation.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Hammond
authors.forename: R A
authors.initials: RA
authors.lastname: Augustyniak
authors.forename: N F
authors.initials: NF
authors.lastname: Rossi
authors.forename: P C
authors.initials: PC
authors.lastname: Churchill
authors.forename: K
authors.initials: K
authors.lastname: Lapanowski
authors.forename: D S
authors.initials: DS
authors.lastname: O'Leary
mesh_terms: D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001696:Biomechanical Phenomena; D001794:Blood Pressure; D002302:Cardiac Output; D002303:Cardiac Output, Low / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009638:Norepinephrine / Q000097:blood; D005082:Physical Exertion; D012018:Reflex; D012039:Regional Blood Flow; D012083:Renin / Q000097:blood; D014667:Vasopressins / Q000097:blood
chemical_list: D014667:Vasopressins; D012083:Renin; D009638:Norepinephrine