title: Expression of chick BMP-1/Tolloid during patterning of the neural tube and somites.
abstract: The expression pattern described here is that of the chick BMP-1/Tolloid family of secreted metalloproteinases during early stages of development. BMP-1/Tolloid transcripts are expressed in the blastoderm, at gastrulation stages and as the neural plate forms and neural tube folds, BMP-1/Tolloid is found at the neural plate/ectodermal transition. Expression is maintained in the premigratory neural crest, and transiently in the migrating cephalic neural crest cells. BMP-1/Tolloid is also expressed in the caudal, but not in the anterior notochord, and in the ventral neural tube at the time of dorso-ventral patterning. Further sites of BMP-1/Tolloid expression are the lateral plate mesoderm and the dermotome and the myotome of the somites.
authors.affiliation: Instituto Cajal de Neurobiología, C.S.I.C., Av. Doctor Arce 37, E-28002, Madrid, Spain. marti@cajal.csic.es
authors.forename: E
authors.initials: E
authors.lastname: Martí
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D055395:Bone Morphogenetic Protein 1; D019485:Bone Morphogenetic Proteins / Q000235:genetics*; D002642:Chick Embryo; D002970:Cleavage Stage, Ovum / Q000502:physiology; D015870:Gene Expression; D008666:Metalloendopeptidases / Q000235:genetics*; D045726:Metalloproteases; D011506:Proteins / Q000235:genetics*; D019170:Somites; D055394:Tolloid-Like Metalloproteinases
chemical_list: D019485:Bone Morphogenetic Proteins; D011506:Proteins; D045726:Metalloproteases; D055394:Tolloid-Like Metalloproteinases; D008666:Metalloendopeptidases; D055395:Bone Morphogenetic Protein 1