Nafarelin acetate for pituitary suppressions in in-vitro fertilisation cycles--a Singaporean experience.
OBJECTIVE
The aim of this prospective clinical trial was to determine if intranasal nafarelin acetate (NA) is as effective as leuprolide (LA), our standard GnRHa, in IVF cycles. In addition, we believe that this may be the first report of such a trial in an Asian IVF population.


METHODS
Midluteal GnRHa administration (LA = 0.5 mg/d; NA = 800 micrograms/d) was used with a standardised hMG ovarian stimulation protocol for all 88 consecutive cycles, randomised at recruitment.


RESULTS
There were no significant differences between LA and NA in terms of the mean duration of agonist to reach pituitary suppression, total hMG dosage, number of embryos produced or frozen and the clinical pregnancy rate (LA = 21.4% and NA = 16.3% per cycle).


CONCLUSIONS
Intranasal nafarelin acetate was as effective as leuprolide acetate in our series of IVF patients of Asian origin, and may be offered as an alternative choice for pituitary suppression.
Loh
S K
SK
Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore.
Leong
N K
NK
D000281:Administration, Intranasal; D000328:Adult; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro; D006728:Hormones / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D017274:Nafarelin / Q000494:pharmacology* / Q000627:therapeutic use; D010060:Ovulation; D010902:Pituitary Gland / Q000187:drug effects* / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D012846:Singapore
D005300:Fertility Agents, Female; D006728:Hormones; D017274:Nafarelin; D016729:Leuprolide