title: The anatomy of aphasia revisited.
abstract: OBJECTIVE
  To determine lesion locations associated with the various types of aphasic disorders in patients with stroke.
  
  
  BACKGROUND
  The anatomy of aphasia has been challenged by several recent studies. Discrepancies are likely to be due to methodologic issues.
  
  
  METHODS
  We examined 107 patients with a standardized aphasia battery and MRI. Three examiners blinded to the clinical data rated signal abnormalities in 69 predetermined regions of interest. The statistical procedure used classification tree testing, which selected regions associated with each aphasic disorder.
  
  
  RESULTS
  1) Nonfluent aphasia depended on the presence of frontal or putaminal lesions; 2) repetition disorder on insula-external capsule lesions; 3) comprehension disorder on posterior lesions of the temporal gyri; 4) phonemic paraphasia on external capsule lesions extending either to the posterior part of the temporal lobe or to the internal capsule; 5) verbal paraphasia on temporal or caudate lesions; and 6) perseveration on caudate lesions. These analyses correctly classified 67% to 94% of patients.
  
  
  CONCLUSIONS
  Lesion location is the main determinant of aphasic disorders at the acute stage. Most clinical-radiologic correlations supported the classic anatomy of aphasia.
authors.affiliation: Department of Neurology, Lille University Hospital, France.
authors.forename: A
authors.initials: A
authors.lastname: Kreisler
authors.forename: O
authors.initials: O
authors.lastname: Godefroy
authors.forename: C
authors.initials: C
authors.lastname: Delmaire
authors.forename: B
authors.initials: B
authors.lastname: Debachy
authors.forename: M
authors.initials: M
authors.lastname: Leclercq
authors.forename: J P
authors.initials: JP
authors.lastname: Pruvo
authors.forename: D
authors.initials: D
authors.lastname: Leys
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000473:pathology*; D013577:Syndrome