Protein kinases: six degrees of separation?
Recent evidence for cross-talk between protein kinase B (PKB) and the Raf-1 and NF-kappaB signalling pathways has provided new hints to the complex roles that PKB may play in regulating gene transcription and also raised questions about where and when these targets are relevant.
Scheid
M P
MP
Ontario Cancer Institute, Toronto, M5G 2M9, Canada.
Woodgett
J R
JR
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D002470:Cell Survival; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000502:physiology*; D051057:Proto-Oncogene Proteins c-akt; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D015398:Signal Transduction; D014158:Transcription, Genetic
D008024:Ligands; D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D019908:Proto-Oncogene Proteins c-raf