PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities.
Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies. PF1163A and B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. These compounds inhibited the ergosterol biosynthesis in Candida albicans.
Nose
H
H
Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan.
Seki
A
A
Yaguchi
T
T
Hosoya
A
A
Sasaki
T
T
Hoshiko
S
S
Shomura
T
T
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000378:metabolism; D004875:Ergosterol / Q000096:biosynthesis; D005285:Fermentation; D006801:Humans; D047028:Macrocyclic Compounds; D008826:Microbial Sensitivity Tests; D010407:Penicillium; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000935:Antifungal Agents; D047028:Macrocyclic Compounds; C405057:PF 1163A; C405058:PF 1163B; D004875:Ergosterol