[Effects of metabolic therapy on intracellular level of antioxidant system in elderly patients with ischemic heart disease].
Patients with ischemic heart disease (angina pectoris of functional class II and III) whose mean age was 67.4 +/- 1.67 years were divided into 3 randomized groups. 15 control patients received standard treatment. 30 and 15 patients of group 1 and 2, respectively, received standard treatment plus amino acid composition (100 mg 3 times a day sublingually) or preductal (20 mg 3 times a day)--groups 1 and 2, respectively. The treatment lasted 21 days. Before the treatment and on its day 1, 7 and 21 measurements were made of glutathione level, activity of glutathion-dependent enzymes, catalase, Cu, Zn-superoxide dismutase and malonic dialdehyde in red cells. The amino acid composition was found to raise the level of antioxidant system and suppress lipid peroxidation. Preductal raised the activity of Cu, Zn-superoxide dismutase and had an unbalanced effect on the antioxidant system.
Kalinina
E V
EV
Komissarova
I A
IA
Zaslavskaia
R M
RM
Novichkova
M D
MD
Kelimberdieva
E S
ES
D000368:Aged; D000596:Amino Acids / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000188:drug therapy* / Q000378:metabolism; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D016896:Treatment Outcome; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use*
D000596:Amino Acids; D014665:Vasodilator Agents; D010088:Oxidoreductases; D005978:Glutathione; D014292:Trimetazidine