Preventive effect of melatonin on the progression of carbon tetrachloride-induced acute liver injury in rats.
We examined the preventive effect of melatonin on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rats. In rats injected with CCl4 (1.0 ml/kg body weight), liver injury appeared 6 h after the injection and progressed at 24 h. This liver injury progression was prevented by treatment with melatonin (50 or 100 mg/kg body weight), which was conducted 6 h after CCl4 injection. An increase in liver lipid peroxide content and a decrease in liver reduced glutathione content occurred with the liver injury progression. These changes were prevented by the post-treatment of melatonin (50 or 100 mg/kg body weight). These results indicate that melatonin can prevent the progression of CCl4-induced acute liver injury through its antioxidant action.
Ohta
Y
Y
Department of Biochemistry, School of Medicine, Fujita Health University, Aichi, Japan.
Kongo
M
M
Sasaki
E
E
Nishida
K
K
Ishiguro
I
I
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology* / Q000517:prevention & control*; D018450:Disease Progression; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008550:Melatonin / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000975:Antioxidants; D008550:Melatonin