title: Psychopathology in treated Wilson's disease determined by means of CPRS expert and self-ratings.
abstract: OBJECTIVE
  To examine the occurrence and severity of psychopathological symptoms in patients with treated Wilson's disease (WD) and to evaluate the clinical utility of a self-assessment.
  
  
  METHODS
  Twenty-six consecutive patients with confirmed WD were investigated using the Comprehensive Psychopathological Rating Scale (CPRS) and the CPRS Self-rating Scale.
  
  
  RESULTS
  The total CPRS scores ranged from 2.5 to 59.0 (mean 29.4 +/- 15.5). Most common symptoms were: autonomic disturbances, observed muscular tension, fatiguability, reduced sexual interest, lack of appropriate emotion, concentration difficulties, reduced sleep, aches and pains, hostile feelings, apparent sadness and failing memory. Agreement between interview-based ratings and self-ratings was low.
  
  
  CONCLUSIONS
  The patients with treated WD have prominent psychopathology in the same range as in patients with moderate to severe depressive disorders. A specific symptom profile has been identified. If confirmed, the identification of the typical symptom profile might be of great importance. The patients with WD tend to underestimate the presence of psychopathological symptoms.
authors.affiliation: Department of Neuroscience, Psychiatry, Uppsala University Hospital, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Portala
authors.forename: K
authors.initials: K
authors.lastname: Westermark
authors.forename: L
authors.initials: L
authors.lastname: von Knorring
authors.forename: L
authors.initials: L
authors.lastname: Ekselius
mesh_terms: D000328:Adult; D005104:Expert Testimony; D005260:Female; D006527:Hepatolenticular Degeneration / Q000523:psychology*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012647:Self-Assessment; D012720:Severity of Illness Index; D013001:Somatoform Disorders / Q000175:diagnosis / Q000209:etiology