Giant negative T waves in Guillain-Barré syndrome.
A Guillain-Barré syndrome patient showed giant negative T waves on electrocardiography at the height of the disease, with large left ventricular hypokinesis on echocardiography and extensive defects on 123I-meta-iodobenzylguanidine myocardial scintigraphy. Gamma-globulin improved the neurological symptoms, and the above abnormalities resolved. We speculate that cardiac sympathetic nerve endings were transiently damaged, with consequent myocardial injury, due to norepinephrine toxicity.
Yoshii
F
F
Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan.
Kozuma
R
R
Haida
M
M
Shinohara
Y
Y
Yoshitake
M
M
Abe
S
S
Handa
S
S
D019797:3-Iodobenzylguanidine / Q000031:analogs & derivatives; D000368:Aged; D004452:Echocardiography / Q000379:methods; D005260:Female; D020275:Guillain-Barre Syndrome / Q000150:complications* / Q000503:physiopathology; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008475:Median Nerve / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology; D010543:Peroneal Nerve / Q000503:physiopathology; D012720:Severity of Illness Index; D013565:Sympatholytics; D013599:Systole / Q000502:physiology; D013979:Tibial Nerve / Q000503:physiopathology; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology
D013565:Sympatholytics; C049322:4-amino-3-iodobenzylguanidine; D019797:3-Iodobenzylguanidine