Neurotrophins: neurotrophic modulation of neurite growth.
As well as regulating neuronal survival, neurotrophins control the growth of axons and dendrites. New light has been shed on the mechanism of this latter control process by the discovery that the common neurotrophin receptor p75(NTR) interacts in a ligand-dependent manner with RhoA, a known regulator of actin assembly.
Davies
A M
AM
School of Biology, Bute Medical Buildings, University of St. Andrews, St. Andrews, KY16 9TS, UK. amd2@st-and.ac.uk.
D000818:Animals; D002455:Cell Division; D015723:Gene Library; D006023:Glycoproteins / Q000378:metabolism; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology*; D016501:Neurites / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism* / Q000502:physiology*; D020917:Receptor, trkA / Q000378:metabolism
D006023:Glycoproteins; D009414:Nerve Growth Factors; D020800:Receptor, Nerve Growth Factor; D011505:Protein-Tyrosine Kinases; D020917:Receptor, trkA