title: MRI pontine hyperintensity after supratentorial ischemic stroke relates to poor clinical outcome.
abstract: OBJECTIVE
  MRI studies in patients with atherosclerosis often reveal ill-defined hyperintensity in the pons on T2-weighted images. This pontine hyperintensity (PHI) does not fulfill the criteria of a brain infarct, and its clinical relevance is not established. We examined the frequency, as well as the radiological and clinical correlates, of PHI in poststroke patients.
  
  
  METHODS
  Three hundred nineteen patients were studied 3 months after supratentorial ischemic stroke with the use of 1.0-T MRI. Brain infarcts, atrophy, white matter hyperintensities, and PHI were registered. The clinical outcome was assessed 3 and 15 months after the stroke.
  
  
  RESULTS
  Of the patients, 152 (47.6%) had PHI. The risk factors for stroke did not differ in patients without or with PHI. PHI was related to a higher frequency (P=0.002) and larger volume (P<0.001) of supratentorial brain infarcts, to parietal (P=0.020) and temporal (P=0.002) atrophy, to central atrophy (P< or =0.040), and to white matter hyperintensity grade (P<0.001). Brain infarcts that affected the corpus striatum (putamen, caudate, and pallidum) (P< or =0. 011) or pyramidal tract (P<0.001) were more frequent in patients with PHI. The 3- and 15-month outcomes were worse in patients with PHI (P< or =0.004). The total volume of brain infarcts (OR 1.22), mean atrophy (OR 3.59), and PHI (OR 3.76) were independent correlates of a poor 15-month outcome.
  
  
  CONCLUSIONS
  PHI after supratentorial ischemic stroke deserves attention because it relates to poor clinical outcome.
authors.affiliation: Departments of Radiology, Helsinki University Central Hospital, Helsinki, Finland. ritta.mantyla@helsinki.fi
authors.forename: R
authors.initials: R
authors.lastname: Mäntylä
authors.forename: T
authors.initials: T
authors.lastname: Pohjasvaara
authors.forename: R
authors.initials: R
authors.lastname: Vataja
authors.forename: O
authors.initials: O
authors.lastname: Salonen
authors.forename: H J
authors.initials: HJ
authors.lastname: Aronen
authors.forename: C G
authors.initials: CG
authors.lastname: Standertskjöld-Nordenstam
authors.forename: M
authors.initials: M
authors.lastname: Kaste
authors.forename: T
authors.initials: T
authors.lastname: Erkinjuntti
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000175:diagnosis*; D002526:Cerebellar Diseases / Q000175:diagnosis*; D002552:Cerebral Ventricles / Q000473:pathology; D003342:Corpus Striatum / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011149:Pons / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology*