[The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test].
Antimutagenic activity of 20 and 40% ethanol extracts from the biomass of Rhodiola rosea, Polyscias filicifolia, Panax ginseng and Ungernia victoris cultured cells have been studied. DDDTDP, ethidium bromide, benz(a)pyrene, benzidine served as model mutagens for Salmonella typhimurium TA 98 strain (the latter two were tested in presence of metabolic activation system); for S. typhimurium TA 100 strain these were tio-tefa, bichromate potassium and sodium azide and heavy metal compounds (chlorides of manganese, zinc, cadmium, lead acetate) for both strains. Higher capacity of the extracts from the biomass of R. rosea and P. filicifolia to counteract gene mutations induced by various mutagens was demonstrated (ca. 90% inhibition in isolated cases). In the experiment with the metabolic activation most effective proved to be the extracts from the P. ginseng biomass (up to 34% and 47% mutagenicity inhibition).
Duhan
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Baryliak
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Nester
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Dvornyk
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Kunakh
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D016587:Antimutagenic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests / Q000379:methods / Q000706:statistics & numerical data; D009154:Mutation; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000166:cytology; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics
D016587:Antimutagenic Agents; D010936:Plant Extracts