title: Structure and stereochemistry of the higher bile acid isolated from turtle bile: (22S,25R)-3 alpha,12 alpha,15 alpha,22-tetrahydroxy-5 beta-cholestan-26-oic acid.
abstract: The structure and stereochemistry of the higher bile acid, tetrahydroxyisosterocholanic acid (TISA), which was previously isolated from the bile of Amyda japonica (turtle) and proposed as a tetrahydroxyisosterocholanic acid, have been established as (22S,25R)-3 alpha,12 alpha,15 alpha,22-tetrahydroxy-5 beta-cholestan-26-oic acid by X-ray crystallographic analysis of its ethyl ester.
authors.affiliation: Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kuramoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kameyama
authors.forename: M
authors.initials: M
authors.lastname: Kaneda
authors.forename: M
authors.initials: M
authors.lastname: Shiro
authors.forename: T
authors.initials: T
authors.lastname: Hoshita
authors.forename: M
authors.initials: M
authors.lastname: Une
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry*; D002777:Cholestanols / Q000032:analysis / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D018360:Crystallography, X-Ray; D005704:Gallbladder / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D014426:Turtles / Q000378:metabolism*
chemical_list: C406434:3,12,15,22-tetrahydroxycholestan-26-oic acid; D002777:Cholestanols