title: Childhood sexual abuse and preterm labor in adulthood: an endocrinological hypothesis.
abstract: Anecdotal reports link adverse pregnancy outcomes, such as preterm delivery, to women with histories of childhood sexual abuse. Although little research has been conducted on this subject, we provide an overview of known health effects of violence against women and posit a biological explanation for adverse pregnancy outcomes among this population. Specifically, we hypothesize that early traumatic experiences of childhood sexual abuse may activate corticotropin releasing hormone (CRH) gene expression in the brain, and a vulnerability to elevated CRH gene expression in the placenta. Those traumatized by early abuse may be more susceptible to stress vís a vís CRH dysregulation during a major psychosocial stressor, such as pregnancy. Elevated CRH has been associated with preterm labor.
authors.affiliation: Division of Women's Health Issues, American College of Obstetricians and Gynecologists, Georgetown University, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Horan
authors.forename: L D
authors.initials: LD
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Schulkin
mesh_terms: D000328:Adult; D000818:Animals; D002648:Child; D002650:Child Abuse, Sexual; D002675:Child, Preschool; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D005239:Fear; D005260:Female; D006801:Humans; D009490:Neurosecretory Systems / Q000503:physiopathology; D007752:Obstetric Labor, Premature / Q000209:etiology*; D011247:Pregnancy; D013216:Reflex, Startle; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D003346:Corticotropin-Releasing Hormone