title: Local transrectal enzymatic treatment for chronic nonbacterial prostatitis and prostatodynia: initial clinical experience.
abstract: We report our initial clinical experience with local transrectal application of enzymatic treatment for chronic nonbacterial prostatitis and prostatodynia in 20 patients. Using a specially designed symptom score for evaluation of subjective treatment parameters, a statistically significant improvement of symptoms was found in the areas of pain, micturition, and recreational activities. No statistically significant differences were noted in laboratory values before and after treatment. Minimal local side effects were seen in only one patient. A favorable clinical response was noted in 75% of patients, whereas the remaining 25% showed only moderate improvement of symptoms. No patient experienced complete treatment failure.
authors.affiliation: Department of Urology, University of Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Kerbl
authors.forename: R
authors.initials: R
authors.lastname: Zisch
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000285:Administration, Rectal; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D002918:Chymotrypsin; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D010184:Pancreatic Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D010206:Papain / Q000008:administration & dosage / Q000627:therapeutic use*; D011469:Prostatic Diseases / Q000188:drug therapy; D011472:Prostatitis / Q000188:drug therapy*; D012189:Retrospective Studies; D013949:Thymus Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014357:Trypsin
chemical_list: D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D010184:Pancreatic Extracts; D013949:Thymus Extracts; C009685:chymotrypsin, papain, trypsin drug combination; D002918:Chymotrypsin; D014357:Trypsin; D010206:Papain