Limits to the capacity of transplants of olfactory glia to promote axonal regrowth in the CNS.
Olfactory bulb ensheathing cell (OBEC) transplants promoted axonal regeneration in the spinal cord dorsal root entry zone and in the corticospinal tract. However, OBECs failed to promote abducens internuclear neuron axon regeneration when transplanted at the site of nerve fibre transection. In experiments performed in both cats and rats, OBECs survived for up to 2 months, lining themselves up along the portion of the regrowing axons proximal to the interneuron cell body. However, OBECs migrated preferentially towards abducens somata, in the direction opposite to the oculomotor nucleus target. OBECs seem to promote nerve fibre regeneration only where preferred direction of glial migration coincides with the direction of axonal growth towards its target.
Gudiño-Cabrera
G
G
Departamento de Plasticidad Neural, Instituto Cajal, CSIC, Madrid, Spain.
Pastor
A M
AM
de la Cruz
R R
RR
Delgado-García
J M
JM
Nieto-Sampedro
M
M
D000010:Abducens Nerve / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001369:Axons / Q000502:physiology*; D002415:Cats; D002465:Cell Movement; D002470:Cell Survival; D003714:Denervation; D007395:Interneurons / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology*; D009457:Neuroglia / Q000502:physiology* / Q000637:transplantation*; D009830:Olfactory Bulb / Q000166:cytology*; D011712:Pyramidal Tracts / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000503:physiopathology*