Characterization of breast lesion morphology with delayed 3DSSMT: an adjunct to dynamic breast MRI.
The purpose of the study was to determine the sensitivity and specificity of various morphologic criteria in distinguishing malignant from benign breast lesions using a new sequence (3DSSMT) performed immediately after dynamic breast MRI. 3DSSMT combines a water-selective spectral-spatial excitation and an on-resonance magnetization transfer pulse with three-dimensional spoiled gradient-echo imaging. Morphologic features of 87 pathologically confirmed lesions were analyzed. The presence of either skin thickening, or a combination of a spiculated or microlobulated border, with a rim, ductal, linear, or clumped enhancement pattern was 94% specific and 54% sensitive for malignancy. Conversely, the presence of either a perfectly smooth border, a well-defined margin, non-enhancing internal septations, or a macrolobulated border was 97% specific and 35% sensitive for a benign diagnosis. In conclusion, delayed 3DSSMT discriminates a significant number of benign and malignant breast lesions; it has the potential to improve the diagnostic accuracy of dynamic breast MRI.
Leong
C S
CS
Department of Radiology, Lucas MRS/I Center, Stanford University, California 94305-5488, USA.
Daniel
B L
BL
Herfkens
R J
RJ
Birdwell
R L
RL
Jeffrey
S S
SS
Ikeda
D M
DM
Sawyer-Glover
A M
AM
Glover
G H
GH
D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012680:Sensitivity and Specificity