title: [Regulation of distractional osteogenesis: biochemical aspects].
abstract: The samples of intact compact bone, bone tissue of new-born puppies (BP), distractional regenerate bone (DRB), new cancellous bone (NCB) filling in the transported fragment were fractionated by the degree of maturity while substituting canine tibial shaft defect using bifocal distraction-compression osteosynthesis. Comparative analysis of the composition of the mineral phase and the organic matrix of different derivatives of bone tissue revealed the identity of low-mineralized fractions of BP and NCB. It was suggested that the fractions were produced by DRB cells which were phenotypically different from osteogenic ones. There is evidence that the high proliferating potential of the least mature DRB fraction is maintained by relative hypoxia in the "growth zone" of the latter and by the changing concentrations of local factors depending on the rate of distraction.
authors.forename: V I
authors.initials: VI
authors.lastname: Shevtsov
authors.forename: K S
authors.initials: KS
authors.lastname: Desiatnichenko
authors.forename: O P
authors.initials: OP
authors.lastname: Berezovskaia
authors.forename: L S
authors.initials: LS
authors.lastname: Kuznetsova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015519:Bone Density; D001861:Bone Regeneration / Q000502:physiology*; D001842:Bone and Bones / Q000293:injuries / Q000378:metabolism*; D002455:Cell Division; D004285:Dogs; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D019344:Lactic Acid / Q000378:metabolism; D019289:Pyruvic Acid / Q000378:metabolism
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase