Liver dysfunction due to apoptosis in a patient with systemic lupus erythematosus.
We report on a 23-year-old Japanese female with a 13-year history of systemic lupus erythematosus (SLE), and two episodes of deterioration followed by treatment with high dose prednisolone. Although she had been recently treated with prednisolone (12.5 mg daily), her liver function became worse in July 1998. Results of a liver biopsy revealed multi-focal hepatic cell death in a severe fatty liver, without any inflammatory cell invasion. The biopsy also showed a positive TUNEL (Tdt-catalysed DNA nick end labelling) reaction indicating apoptosis. Her liver function recovered rapidly following steroid pulse therapy. Serum soluble Fas ligand (sFasL) was found to be elevated to a concentration of 0.395 ng/ml at the time of liver damage, but was less than 0.03 ng/ml before liver damage and after prednisolone treatment. The liver damage in this case appeared to be involved with apoptosis induced by sFasL. Although hepatitis associated with SLE is rare, apoptosis directly related to elevated sFasL levels might cause this complication.
Mukai
M
M
Division of Clinical Immunology and Hematology, Department of Medicine,Sapporo City General Hospital, Chuo-ku, Sapporo, Japan. masaya-mukai@hokkaido.med.or.jp
Bohgaki
T
T
Notoya
A
A
Kohno
M
M
Tateno
M
M
Kobayashi
S
S
D000328:Adult; D017209:Apoptosis; D001706:Biopsy; D053222:Fas Ligand Protein; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006505:Hepatitis / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D020287:In Situ Nick-End Labeling; D008024:Ligands; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008562:Membrane Glycoproteins / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D019014:fas Receptor / Q000097:blood
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D005938:Glucocorticoids; D008024:Ligands; D008562:Membrane Glycoproteins; D019014:fas Receptor; D011239:Prednisolone