title: Mood state and recent cocaine use are not associated with levels of cocaine cue reactivity.
abstract: Eighty-one cocaine-dependent outpatients were assessed for their reactions to cocaine-related cues in a laboratory setting. All subjects contributed a urine sample prior to the session. Compared with non-drug control cues, the cocaine stimuli produced increases in physiological arousal, self-reports of high, craving, and withdrawal, and self-reports of negative mood. Subjects who tested cocaine-positive on the day of testing differed only in skin resistance responding from those who tested cocaine-negative. Changes in cue-induced physiological and self-report measures were also not associated with between-subject variations in mood as measured by the Profile of Mood States (POMS) questionnaire administered prior to cue assessment. Thus, variations in baseline mood and recent cocaine use history do not introduce an additional source of variability in cue reactivity measurements. However, negative mood states at the start of a session were associated with higher levels of self-reported craving, high, and withdrawal both before and after cue exposure.
authors.affiliation: Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA. robbins@beaver.edu
authors.forename: S J
authors.initials: SJ
authors.lastname: Robbins
authors.forename: R N
authors.initials: RN
authors.lastname: Ehrman
authors.forename: A R
authors.initials: AR
authors.lastname: Childress
authors.forename: J W
authors.initials: JW
authors.lastname: Cornish
authors.forename: C P
authors.initials: CP
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects*; D001143:Arousal / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage* / Q000009:adverse effects; D019970:Cocaine-Related Disorders / Q000523:psychology* / Q000534:rehabilitation; D016578:Crack Cocaine; D003463:Cues; D004334:Drug Administration Schedule; D005712:Galvanic Skin Response / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009042:Motivation; D016713:Ritanserin / Q000627:therapeutic use
chemical_list: D016578:Crack Cocaine; D016713:Ritanserin; D003042:Cocaine