Apolipoprotein E genotype and lipid and lipoprotein levels in dementia.
In 64 individuals with dementia (26 Alzheimer type, 34 of vascular origin and 4 other types of dementia) apolipoprotein E genotype was identified. Frequency of epsilon4 allele was 36.5% in Alzheimer patients and 32.4% in vascular dementia ones. In a group of 39 nondemented individuals of the same age the epsilon4 frequency was 11.5%. In demented patients, carriers of epsilon4, a tendency to higher plasma levels of atherogenic lipids (total cholesterol and low-density lipoprotein cholesterol) as compared with noncarriers was observed. It is possible that the epsilon4 form may aggravate the course of dementia through a moderate influence on the atherogenic lipoprotein level. The results showed that both Alzheimer disease and vascular dementia shared the same risk factors which is consistent with current opinion about a link existing between these two types of dementia.
Wehr
H
H
Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland. wehr@ipin.edu.pl
Parnowski
T
T
Puzyński
S
S
Bednarska-Makaruk
M
M
Bisko
M
M
Kotapka-Minc
S
S
Rodo
M
M
Wołkowska
M
M
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000097:blood / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D002784:Cholesterol / Q000097:blood; D003704:Dementia / Q000097:blood* / Q000235:genetics*; D015140:Dementia, Vascular / Q000097:blood / Q000235:genetics; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001057:Apolipoproteins E; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol