title: Experience with a strong bleaching treatment for skin hyperpigmentation in Orientals.
abstract: Although a variety of topical treatments have been used for skin hyperpigmentation, the effectiveness of each varies after prolonged treatment. In this study, 136 Oriental patients who were followed up for more than 12 weeks were analyzed. The treatment protocol was composed of two steps: bleaching (2 to 6 weeks) and healing (2 to 6 weeks); 0.1% to 0.4% all-trans retinoic acid aqueous gel was originally prepared and applied concomitantly with hydroquinone-lactic acid ointment for bleaching. After obtaining sufficient improvement of the hyperpigmentation, a corticosteroid was applied topically with hydroquinone and ascorbic acid for healing. Improvement was evaluated with a narrow-band reflectance spectrophotometer. The results were successful in more than 80 percent of cases of senile lentigines and postinflammatory hyperpigmentations, especially on the face. Sixty percent of cases of nevus spilus were also successfully treated. Although the transient adverse effects of this treatment may be more severe than conventional treatment, this strong bleaching protocol improves a variety of hyperpigmented lesions, including nevus spilus, with a higher success rate and a shorter treatment period than conventional protocols.
authors.affiliation: Department of Plastic, Reconstructive, and Aesthetic Surgery, University of Tokyo, Japan. yoshimura-pla@h.u-tokyo.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: K
authors.initials: K
authors.lastname: Harii
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.forename: T
authors.initials: T
authors.lastname: Iga
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D044466:Asian People; D005260:Female; D005782:Gels; D006801:Humans; D006873:Hydroquinones / Q000008:administration & dosage; D017495:Hyperpigmentation / Q000628:therapy*; D007641:Keratolytic Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009824:Ointments; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D005782:Gels; D006873:Hydroquinones; D007641:Keratolytic Agents; D009824:Ointments; D014212:Tretinoin; C031927:hydroquinone