title: Adventures with poxviruses of vertebrates.
abstract: Because they were the largest of all viruses and could be visualised with a light microscope, the poxviruses were the first viruses to be intensively studied in the laboratory. It was clear from an early date that they caused important diseases of humans and their domestic animals, such as smallpox, cowpox, camelpox, sheeppox, fowlpox and goatpox. This essay recounts some of the early history of their recognition and classification and then expands on aspects of research on poxviruses in which the author has been involved. Studies on the best-known genus, Orthopoxvirus, relate to the use of infectious ectromelia of mice as a model for smallpox, embracing both experimental epidemiology and pathogenesis, studies on the genetics of vaccinia virus and the problem of non-genetic reactivation (previously termed 'transformation') and the campaign for the global eradication of smallpox. The other group of poxviruses described here, the genus Leporipoxvirus, came to prominence when the myxoma virus was used for the biological control of Australian wild rabbits. This provided a unique natural experiment on the coevolution of a virus and its host. Future research will include further studies of the many immunomodulatory genes found in all poxviruses of vertebrates, since these provide clues about the workings of the immune system and how viruses have evolved to evade it. Some of the many recombinant poxvirus constructs currently being studied may come into use as vaccines or for immunocontraception. A field that warrants study but will probably remain neglected is the natural history of skunkpox, raccoonpox, taterapox, yabapox, tanapox and other little-known poxviruses. A dismal prospect is the possible use of smallpox virus for bioterrorism.
authors.affiliation: John Curtin School of Medical Research, Australian National University, G.P.O. Box 334, Canberra, Australia. fenner@jcsmr.anu.edu.au
authors.forename: F
authors.initials: F
authors.lastname: Fenner
mesh_terms: D000818:Animals; D049673:History, 20th Century; D006801:Humans; D051379:Mice; D011212:Poxviridae; D011213:Poxviridae Infections / Q000453:epidemiology / Q000266:history / Q000821:virology*; D011817:Rabbits; D012106:Research; D014714:Vertebrates / Q000821:virology*