title: Activation or destruction of T cells via macrophages.
abstract: Macrophages (MPhi) affect the T cell response in two mutually exclusive ways: activation or deletion. A MPhi type with T cell activating functions (M1) is able to express and upregulate receptors of the B7 family. IFN-gamma favours this MPhi differentiation pathway via upregulation of CD80 (B7-1) and CD86 (B7-2). The treatment of MPhi with IFN-gamma enhances the alphaCD3-mediated T cell blast transformation and reduces the fraction of deleted T cells. This MPhi type may prevent antibody-mediated T cell destruction by the expression of costimulatory receptors. An IL-10-induced MPhi type (M2) fails to express costimulatory molecules of the B7 family but is an effective cell for T cell destruction. Forming cellular conjugates with T cells through antibodies or immune complexes, M2-MPhi preferentially delete targeted cells in vitro and in vivo.
authors.affiliation: Children's University Hospital, Tübingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Orlikowsky
authors.forename: G E
authors.initials: GE
authors.lastname: Dannecker
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Horowitz
authors.forename: D
authors.initials: D
authors.lastname: Niethammer
authors.forename: M K
authors.initials: MK
authors.lastname: Hoffmann
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology; D017951:Antigen Presentation / Q000276:immunology*; D017252:CD3 Complex / Q000276:immunology; D002470:Cell Survival; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000187:drug effects / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology*; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D008934:Mitogens; D009500:Neutralization Tests; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic; D015854:Up-Regulation
chemical_list: D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D008934:Mitogens; D007371:Interferon-gamma