title: Inhibition of cathepsin activities by vitamin B6 derivatives.
abstract: We found that pridoxal phosphate (PLP), a coenzyme form of vitamin B6, inhibited the activity of cathepsins B, K, S and L in vitro. Cathepsins activities in cultured splenocytes were suppressed by the addition of pridoxal (PL) or pridoxine (PI) in to the culture medium. A newly synthesized artificial vitamin B6 derivative, a pridoxal propionate derivative, CLIK-164, showed selective inhibition of cathepsin O/K.
authors.affiliation: Tokushima Bunri University, Institute for Health Sciences, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Matsui
authors.forename: H
authors.initials: H
authors.lastname: Tsuzuki
authors.forename: E
authors.initials: E
authors.lastname: Murata
authors.forename: Y
authors.initials: Y
authors.lastname: Tada
authors.forename: T
authors.initials: T
authors.lastname: Asao
authors.forename: N
authors.initials: N
authors.lastname: Katunuma
mesh_terms: D002403:Cathepsins / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D011422:Propionates / Q000494:pharmacology; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013154:Spleen / Q000201:enzymology
chemical_list: C406022:CLIK 164; D004791:Enzyme Inhibitors; D011422:Propionates; D002403:Cathepsins; D011736:Pyridoxine