title: Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet.
abstract: Docosahexaenoic acid (DHA) is an essential nutrient for human health, but has extremely high oxidative susceptibility. We examined the suppressing effect of sesamin, a sesame seed lignan, on lipidperoxides in rats fed a low alpha-tocopherol and high DHA containing diet. Groups of rats were fed four experimental diets: low alpha-tocopherol (10 mg/kg diet) control diet, low alpha-tocopherol + 0.2% sesamin diet, low alpha-tocopherol + 0.5% DHA diet and low alpha-tocopherol + 0.5% DHA + 0.2% sesamin diet. TBARS concentrations in plasma and liver were significantly increased by DHA, but were completely suppressed by sesamin. Alpha-tocopherol concentrations in plasma and liver decreased by addition of DHA, but with sesamin recovered to the control level. The addition of DHA into the diets caused remarkable increases of DHA concentrations in plasma and liver lipids. Sesamin caused a significant increase of DHA concentrations in the triacylglycerol of plasma.
authors.affiliation: Department of Food and Nutrition, Sugiyama Jogakuen University, Nagoya, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamashita
authors.forename: M
authors.initials: M
authors.lastname: Kagaya
authors.forename: N
authors.initials: N
authors.lastname: Higuti
authors.forename: Y
authors.initials: Y
authors.lastname: Kiso
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D004149:Dioxoles / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000008:administration & dosage; D004357:Drug Synergism; D006461:Hemolysis; D017705:Lignans / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood*; D008099:Liver / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D004042:Dietary Fats, Unsaturated; D004149:Dioxoles; D017705:Lignans; D008054:Lipid Peroxides; D014280:Triglycerides; D014810:Vitamin E; D004281:Docosahexaenoic Acids; C054125:sesamin