The potential role of gene therapy in the treatment of bladder cancer.
Based on understanding the molecular mechanism of bladder carcinogenesis, cancer gene therapy may well become a novel therapy in the near future. Currently, a viral vector system appears to be a better vehicle to deliver genes into target cells. Exploring different therapeutic strategies has generated promising results from preclinical bladder cancer models. Phase I clinical trials are underway to study the feasibility of this treatment for human bladder cancer patients. However, several potential problems associated with effective gene delivery need to be further refined.
Hsieh
J T
JT
Department of Urology, UT Southwestern Medical Center, Dallas, Texas, USA.
Dinney
C P
CP
Chung
L W
LW
D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000628:therapy*; D002986:Clinical Trials as Topic; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000628:therapy*