Bioactive alkaloids from Brunsvigia radulosa.
A phytochemical investigation of the bulbs of Brunsvigia radulosa yielded the new alkaloid 1-O-acetylnorpluviine, together with the known structures 1-epideacetylbowdensine, crinamine, crinine, hamayne, lycorine, anhydrolycorin-6-one and sternbergine. All structures were established by spectroscopic evidence. Some of the 13C assignments which were reported for crinamine and hamayne were corrected by means of 2D NMR techniques. In order to provide a further structure for biological testing, crinamine was converted to apohaemanthamine. The alkaloids were tested for activity against two strains of cultured Plasmodium falciparum and for cytotoxicity with BL6 mouse melanoma cells.
Campbell
W E
WE
Chemistry Department, University of Cape Town, Rondeboch, South Africa. skoonin@uctgsh1.uct.ac.za
Nair
J J
JJ
Gammon
D W
DW
Codina
C
C
Bastida
J
J
Viladomat
F
F
Smith
P J
PJ
Albrecht
C F
CF
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D047151:Amaryllidaceae Alkaloids; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D007212:Indolizines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured
C411131:1-O-acetylnorpluviine; D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D007212:Indolizines; C411129:crinamine; C411130:apohemanthamine