PU.1 expression in microglia.
The transcription factor PU.1 has a pivotal role in both the generation and function of macrophages. To determine whether PU.1 is also involved in microglial regulation, we investigated its expression following hypoxic-ischemia (HI) brain injury and in the BV-2 microglial cell line. We found that microglia constitutively expressed high levels of PU.1 protein in both their 'resting' and 'activated' states.
Walton
M R
MR
Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine and Health Science, University of Auckland, Auckland, New Zealand.
Gibbons
H
H
MacGibbon
G A
GA
Sirimanne
E
E
Saura
J
J
Gluckman
P D
PD
Dragunow
M
M
D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D002460:Cell Line; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism*; D007150:Immunohistochemistry; D017628:Microglia / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D015534:Trans-Activators / Q000096:biosynthesis*; D015854:Up-Regulation; D000099232:Proto-Oncogene Protein Spi-1
D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D000099232:Proto-Oncogene Protein Spi-1