title: Aggressive angiomyxoma in females: is radical resection the only option?
abstract: BACKGROUND
  Aggressive angiomyxoma is a rare mesenchymal tumor, characterized by frequent local recurrences. Our aim is to assess the role of radical resection.
  
  
  METHODS
  Retrospective case review. The records of five patients with aggressive angiomyxoma during the period from 1984 to 1998 were reviewed and analyzed. A MEDLINE search from 1983 to May 1999 was performed. The clinical presentation, surgical treatment, resection margin involvement and clinical outcomes were analyzed.
  
  
  RESULTS
  Together with our five cases, 106 cases have been reported in the world literature. The female-to-male ratio was 6.6:1. The age distribution was wide, with the peak incidence at 31 to 35. The local recurrence rate was high. Seventy-one percent of recurrence occurred within the first 3 years. Patients with clear resection margins have similar chances of remaining disease-free compared with those having tumor-involved resection margins. There was no correlation between the size of the tumors and the chance of recurrence.
  
  
  CONCLUSIONS
  Though we aim for complete resection, incomplete or partial resection is acceptable, especially when high operative morbidity is anticipated and preservation of fertility is an issue. Long-term follow-up and careful monitoring with imaging techniques are essential for timely identification of recurrence and prompt resection.
authors.affiliation: Department of Obstetrics and Gynecology, University of Hong Kong, Queen Mary Hospital, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Chan
authors.forename: E
authors.initials: E
authors.lastname: Hon
authors.forename: S W
authors.initials: SW
authors.lastname: Ngai
authors.forename: T Y
authors.initials: TY
authors.lastname: Ng
authors.forename: L C
authors.initials: LC
authors.lastname: Wong
authors.forename: I M
authors.initials: IM
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005833:Genital Neoplasms, Female / Q000401:mortality* / Q000601:surgery*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009232:Myxoma / Q000401:mortality* / Q000601:surgery*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D012189:Retrospective Studies