Effect of albumin administration on L-tryptophan levels in the serum and tissues of rats with puromycin aminonucleoside-induced nephrosis.
We examined the effect of albumin administration on L-tryptophan (Trp) levels in the serum and tissues of rats with puromycin aminonucleoside (PAN)-induced nephrosis. PNA-injected rats showed increased urinary protein and serum non-esterified fatty acids levels and decreased serum albumin level at 8 days after the injection. The nephrotic rats showed a decrease in total serum Trp level and increases in free serum Trp and liver and kidney Trp levels but no change in urinary Trp level. At 5 min after intravenous injection of bovine serum albumin, the nephrotic rats had serum albumin concentration similar to the level of non-nephrotic rats and showed a recovery of decreased total serum Trp with the reduction of increased free serum Trp and liver Trp.
Sasaki
E
E
Department of Biochemistry, School of Medicine, Fujita Health University, Aichi, Japan.
Ohta
Y
Y
Ishiguro
I
I
D000818:Animals; D002417:Cattle; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009401:Nephrosis / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D011507:Proteinuria; D011692:Puromycin Aminonucleoside / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000494:pharmacology*; D014364:Tryptophan / Q000097:blood / Q000378:metabolism*
D012710:Serum Albumin, Bovine; D011692:Puromycin Aminonucleoside; D014364:Tryptophan