Applications of (7)Li NMR in biomedicine.
The applications of (7)Li NMR spectroscopy and imaging in biology and experimental medicine have been progressing steadily. The interest derives primarily from the clinical use of Li salts to treat mania and manic-depressive illness. One area of investigation is ionic transport across the cellular membrane and compartmentation, so as to elucidate the mechanism(s) of therapeutic action and toxicity in clinical practice. The second is the development of a noninvasive, in vivo analytical tool to measure brain Li concentrations in humans, both as an adjunct to treatment and as a mechanistic probe. Here we review progress to date in this area.
Komoroski
R A
RA
Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. komoroskiricharda@exchange.uams.edu
D000818:Animals; D001682:Biological Availability; D001714:Bipolar Disorder / Q000188:drug therapy / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D008094:Lithium / Q000493:pharmacokinetics*; D016651:Lithium Carbonate / Q000493:pharmacokinetics / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008657:Metabolic Clearance Rate / Q000502:physiology
D016651:Lithium Carbonate; D008094:Lithium