Direct lithiation and alkylation of trifluoromethyl enol ethers having a beta-sulfur substituent.
The direct lithiation and alkylation of beta-sulfur-alpha-trifluoromethyl substituted enol ethers 1-3 proceeded to give the alkylated products 4a-f, 5, 6a-c in moderate to high yields.
Yoshimatsu
M
M
Department of Chemistry, Faculty of Education, Gifu University, Japan.
Kinoshita
S
S
D000478:Alkylation; D005019:Ethyl Ethers / Q000737:chemistry*; D007202:Indicators and Reagents; D008094:Lithium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011437:Propylamines; D013455:Sulfur / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
D005019:Ethyl Ethers; D007202:Indicators and Reagents; D011437:Propylamines; D014753:Vinyl Compounds; D013455:Sulfur; D008094:Lithium; C007442:diisopropylamine