Kinases of the Src family: structure and functions.
Tyrosine kinases of the Src family are involved in different signal transduction pathways in cells. The corresponding genes participate in such vital processes as growth, differentiation, adhesion, transcription, etc. Specific structural changes confer oncogenic properties to the Src protein. In this review, we summarize the available data on the structure, substrates, regulation mechanisms, and role of nonreceptor tyrosine kinases by the example of the src gene product (as the prototype member of this family) and a number of related proteins.
Tatosyan
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AG
Institute of Carcinogenesis, Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, 115478, Russia. tatosyan@space.ru
Mizenina
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OA
D000818:Animals; D017209:Apoptosis; D002448:Cell Adhesion; D002453:Cell Cycle; D002454:Cell Differentiation; D002465:Cell Movement; D015971:Gene Expression Regulation, Enzymologic; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014158:Transcription, Genetic; D019061:src-Family Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D019061:src-Family Kinases