Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay.
The non-nutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin and sucralose were tested for DNA damaging activity in the rat hepatocyte/DNA repair assay. Using hepatocytes from F344 and Sprague-Dawley male rats, all were inactive despite strong responses for the positive control, 2-aminofluorene.
Jeffrey
A M
AM
New York Medical College, Department of Pathology, Basic Sciences Building, Valhalla, NY 10595, USA.
Williams
G M
GM
D000818:Animals; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D004260:DNA Repair; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009152:Mutagenicity Tests; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D013549:Sweetening Agents / Q000633:toxicity*
D013549:Sweetening Agents; D004247:DNA