Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon.
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.
Deonarain
R
R
MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom.
Alcamí
A
A
Alexiou
M
M
Dallman
M J
MJ
Gewert
D R
DR
Porter
A C
AC
D000818:Animals; D000998:Antiviral Agents / Q000502:physiology*; D001483:Base Sequence; D002478:Cells, Cultured; D017931:DNA Primers; D020022:Genetic Predisposition to Disease; D007370:Interferon Type I / Q000096:biosynthesis* / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D014777:Virus Diseases / Q000235:genetics
D000998:Antiviral Agents; D017931:DNA Primers; D007370:Interferon Type I