Recognition and inhibition of HIV integrase by a novel dinucleotide.
The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually novel dinucleotide, pIsodApdC, which is a potent inhibitor of this key viral enzyme.
Taktakishvili
M
M
Department of Chemistry, The University of Iowa, Iowa City 52242, USA.
Neamati
N
N
Pommier
Y
Y
Nair
V
V
D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D009711:Nucleotides / Q000378:metabolism*
D019428:HIV Integrase Inhibitors; D009711:Nucleotides; D019427:HIV Integrase