Trypanosoma brucei RNase HI requires its divergent spacer subdomain for enzymatic function and its conserved RNA binding motif for nuclear localization.
Kobil
J H
JH
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Box GB-6, Brown University, Providence, RI 02912,USA.
Campbell
A G
AG
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D011485:Protein Binding; D015800:Protozoan Proteins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D016053:RNA, Protozoan / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D016914:Ribonuclease H / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D014346:Trypanosoma brucei brucei / Q000201:enzymology*
D015800:Protozoan Proteins; D016053:RNA, Protozoan; D016601:RNA-Binding Proteins; D016914:Ribonuclease H; C078856:ribonuclease HI