title: Correlation of TGF beta 1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts.
abstract: The epidemiologic association of human papillomavirus (HPV) infection with dysplasia and cervical cancer is well established. Transforming growth factor beta 1 (TGF beta 1) has regulatory effects on a broad spectrum of cell types and is a growth inhibitory protein for epithelial cells. To examine the phenotype of experimentally generated, HPV-11 transformed human tissues, we looked at expression of TGF beta 1 and a number of proliferation-enhancing molecules which are known to be regulated by TGF beta 1, including bcl-2, c-myc, c-Ha-ras, c-jun and NFkB. HPV-11 transformed xenografts showed up-regulation of TGF beta 1 expression and down-regulation of the expression levels of bcl-2, c-myc, c-Ha-ras, c-jun and NFkB. These results suggest that TGF beta 1 may exert antiproliferative effects on HPV-11 transformed papillomas by down-regulating different proliferation-enhancing molecules.
authors.affiliation: Department of Microbiology and Immunology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine 17033, USA.
authors.forename: M K
authors.initials: MK
authors.lastname: Shier
authors.forename: E B
authors.initials: EB
authors.lastname: Neely
authors.forename: M G
authors.initials: MG
authors.lastname: Ward
authors.forename: M E
authors.initials: ME
authors.lastname: Richards
authors.forename: E C
authors.initials: EC
authors.lastname: Manders
authors.forename: C
authors.initials: C
authors.lastname: Meyers
authors.forename: M K
authors.initials: MK
authors.lastname: Howett
mesh_terms: D001483:Base Sequence; D002455:Cell Division / Q000502:physiology*; D002472:Cell Transformation, Viral; D017931:DNA Primers; D015536:Down-Regulation; D006801:Humans; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D027383:Papillomaviridae / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016212:Transforming Growth Factor beta / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D017931:DNA Primers; D016328:NF-kappa B; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta