Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions.
Three experiments investigated effects of jejunal lipid infusions given on 4 or 21 consecutive days in adult, male Sprague-Dawley rats. In experiment 1, 7-h infusions of linoleic or oleic acid (0.2 ml/h for 7 h; total load = 11.5 kcal) on 4 consecutive days reduced total intake (ad libitum consumption of the liquid diet Boost, Mead Johnson, plus load) by approximately 15% and decreased weight gain compared with 4-day tests with saline administration. In experiment 2, linoleic acid at 0.1 ml/h for 7 h (5.7 kcal) was ineffective, whereas the same load delivered in 3.5 h produced effects similar in magnitude to those in the first experiment. In experiment 3, jejunal infusions of linoleic acid (0.2 ml/h for 7 h) on 21 consecutive days reduced mean total intake by 16%, body weight by 10%, and carcass fat by 48% compared with controls receiving saline. The net decrease in caloric intake may reflect the combined activation of pre- and postabsorptive mechanisms, and it suggests a possible treatment for obesity.
Cox
J E
JE
Department of Psychology, University of Alabama at Birmingham, Alabama 35294, USA. jecox@uab.edu
Tyler
W J
WJ
Randich
A
A
Kelm
G R
GR
Bharaj
S S
SS
Jandacek
R J
RJ
Meller
S T
ST
D000273:Adipose Tissue / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D007583:Jejunum / Q000187:drug effects / Q000502:physiology*; D019787:Linoleic Acid / Q000008:administration & dosage*; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
D019301:Oleic Acid; D019787:Linoleic Acid