Antinociceptive effects induced by intra-periaqueductal grey administration of neuropeptide Y in rats.
Hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation increased dose-dependently after intra-periaqueductal grey (PAG) injection of neuropeptide Y (NPY). Furthermore, the NPY-induced increases in HWLs were attenuated by intra-PAG injection of the Y1 receptor antagonist NPY28-36. The results demonstrated that NPY plays an important role in antinociception in PAG, in which Y1 receptor is involved in.
Wang
J Z
JZ
Department of Physiology, College of Life Science, Peking University, Beijing, China.
Lundeberg
T
T
Yu
L
L
D000698:Analgesia; D000818:Animals; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism* / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology*; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D010147:Pain Measurement; D010487:Periaqueductal Gray / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009478:Neuropeptide Y