Unusual CD4+CD8+ phenotype in a greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I).
We describe the first Greek patient diagnosed with Adult T cell leukemia (ATL) characterized by an expansion of CD4+CD8+ double positive lymphocytes. Low levels of plasma antibodies against HTLV-I Env and Gag proteins were detected. Analysis of the the patient's DNA revealed that she was infected by a cosmopolitan strain of HTLV-I. Since HTLV-I usually leads to the expansion of CD4+ cells, this patient illustrates a rare immunophenotype, which suggests that the HTLV-I-induced proliferative response may occur in a pre-T cell stage.
Ciminale
V
V
Department of Hematology, Metaxa Cancer Hospital of Piraeus, Piraeus, Greece.
Hatziyanni
M
M
Felber
B K
BK
Bear
J
J
Hatzakis
A
A
Pavlakis
G N
GN
D001483:Base Sequence; D015704:CD4 Antigens / Q000032:analysis*; D016827:CD8 Antigens / Q000032:analysis*; D005260:Female; D015481:HTLV-I Antibodies / Q000097:blood; D015368:Human T-lymphotropic virus 1 / Q000145:classification / Q000302:isolation & purification*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology* / Q000821:virology; D008875:Middle Aged; D008969:Molecular Sequence Data; D010641:Phenotype
D015704:CD4 Antigens; D016827:CD8 Antigens; D015481:HTLV-I Antibodies