Lack of relationship between plasma thrombomodulin and portal hypertension in alcoholic liver disease.
The present study was performed to analyze the relationship between portal hypertension and alterations of the endothelium-derived proteins thrombomodulin, plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1), which were determined in plasma samples of 28 alcoholic cirrhotic patients and 46 controls. Although cirrhotics showed lower levels of PAI-1, but higher thrombomodulin and t-PA levels than controls, no relationship was observed between thrombomodulin, t-PA or PAI-1 and portal pressure. Therefore, the hypothesis that splachnic endothelial damage secondary to portal hypertension leads to altered thrombomodulin, t-PA and PAI-1 levels in alcoholic cirrhosis is not supported by the results of this study.
Alemán-Valls
M R
MR
Dpto. de Medicina Interna, Hospital Universitario de Canarias, Tenerife, Canary Islands, Spain.
González-Reimers
E
E
Santolaria-Fernández
F
F
Rodríguez-Martín
J M
JM
Díaz-Romero
F
F
Raya-Sánchez
J M
JM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000097:blood*; D008108:Liver Diseases, Alcoholic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D018180:Thrombomodulin / Q000097:blood*; D010959:Tissue Plasminogen Activator / Q000378:metabolism
D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D010959:Tissue Plasminogen Activator