title: Latanoprost-induced iris color darkening: a case report with long-term follow-up.
abstract: OBJECTIVE
  To determine the effect on iris color of discontinuing latanoprost (LP) treatment in a patient with pronounced iris color darkening, and to assess the possible role of sympathetic innervation.
  
  
  METHODS
  In a patient demonstrating pronounced iris color darkening in both eyes after treatment with LP for 6 months, magnified iris color photographs were taken at 3- to 6-month intervals for 5 years after discontinuation of LP treatment. Pupillary testing for sympathetic insufficiency was performed with cocaine 10% or hydroxyamphetamine 1%.
  
  
  RESULTS
  The iris color did not appreciably change after discontinuing LP. The cocaine-induced increase in pupillary diameter was considerably greater for the control subject than for the patient who demonstrated the LP-induced color change.
  
  
  CONCLUSIONS
  Latanoprost-induced iris color darkening does not appreciably change for several years after discontinuing treatment. Some eyes that show LP-induced darkening may have relative ocular sympathetic insufficiency.
authors.affiliation: Department of Ophthalmology, University of Nebraska Medical Center, Omaha 68198-5540, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Camras
authors.forename: D G
authors.initials: DG
authors.lastname: Neely
authors.forename: E L
authors.initials: EL
authors.lastname: Weiss
mesh_terms: D000959:Antihypertensive Agents / Q000009:adverse effects*; D001342:Autonomic Nervous System Diseases / Q000175:diagnosis; D003042:Cocaine / Q000008:administration & dosage; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000187:drug effects* / Q000294:innervation; D007499:Iris Diseases / Q000139:chemically induced* / Q000473:pathology; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects*; D011680:Pupil / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000473:pathology
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D003042:Cocaine