CD164--a novel sialomucin on CD34+ cells.
Hematopoiesis in adult bone marrow is a tightly regulated process involving interactions between cytokine and adhesion receptors on hematopoietic progenitor cells and their cognate ligands in the immediate microenvironment. These interactions control hematopoietic stem cell self-renewal, quiescence, commitment and migration. Recently, sialomucins have assumed some importance in hematopoiesis, with six of these receptors, CD34, PSGL-1, CD43, PCLP, CD45RA and CD164, having been identified on primitive hematopoietic precursor cells and/or their associated stromal/endothelial elements. This article reviews the cloning, expression and function of the recently identified sialomucin, CD164, which is highly expressed by primitive hematopoietic progenitor cells. The CD164 receptor is implicated in mediating or regulating hematopoietic precursor cell adhesion to stroma, and may serve as a potent negative regulator of hematopoietic progenitor cell proliferation.
Watt
S M
SM
The MRC Molecular Haematology Unit, Institute of Molecular Medicine, The John Radcliffe Hospital, Oxford, UK. Swatt@worf.molbiol.ox.ac.uk
Chan
J Y
JY
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34 / Q000737:chemistry; D051929:CD146 Antigen; D051930:Endolyn; D000939:Epitopes; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008562:Membrane Glycoproteins; D009077:Mucins / Q000737:chemistry; D019006:Neural Cell Adhesion Molecules; D020033:Protein Isoforms; D012333:RNA, Messenger; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D052116:Sialomucins
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34; D051929:CD146 Antigen; C497898:CD164 protein, human; D051930:Endolyn; D000939:Epitopes; D008024:Ligands; D008562:Membrane Glycoproteins; D009077:Mucins; D019006:Neural Cell Adhesion Molecules; D020033:Protein Isoforms; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D052116:Sialomucins