Hormonal side effects in women: typical versus atypical antipsychotic treatment.
Neuroleptic-induced hyperprolactinemia can cause menstrual disorders, impaired fertility, galactorrhea, and sexual dysfunction, as well as hypoestrogenism secondary to disruption of the hypothalamic-pituitary-ovarian axis. The development of the prolactin-sparing atypical antipsychotic drugs offers prevention and resolution of these adverse reactions. Thus far, this property of the new medications has received insufficient clinical attention. The authors use case vignettes to discuss assessment and management of clinical situations that arise as a result of antipsychotic-induced endocrine changes.
Dickson
R A
RA
Department of Psychiatry, University of Calgary, Alberta, Canada.
Seeman
M V
MV
Corenblum
B
B
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced* / Q000517:prevention & control; D007006:Hypogonadism / Q000139:chemically induced / Q000517:prevention & control; D008599:Menstruation Disturbances / Q000139:chemically induced / Q000517:prevention & control; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D011788:Quality of Life; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000517:prevention & control
D014150:Antipsychotic Agents; D011388:Prolactin