Interleukin-18: biological properties and clinical implications.
IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.
Lebel-Binay
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Luti/Laboratoire de Recherche Chirurgicale, Bât. Gustave-Roussy, 3e étage, Hôpital Cochin, 27, rue du Faubourg-St-Jacques, 75014 Paris, France. sophie.lebel-binay@cochin.univ-paris5.fr
Berger
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A
Zinzindohoué
F
F
Cugnenc
P
P
Thiounn
N
N
Fridman
W H
WH
Pagès
F
F
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D003141:Communicable Diseases / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology; D020382:Interleukin-18 / Q000502:physiology*; D053727:Interleukin-18 Receptor alpha Subunit; D009369:Neoplasms / Q000276:immunology; D018123:Receptors, Interleukin / Q000502:physiology; D053724:Receptors, Interleukin-18
D016207:Cytokines; C508572:IL18R1 protein, human; D020382:Interleukin-18; D053727:Interleukin-18 Receptor alpha Subunit; D018123:Receptors, Interleukin; D053724:Receptors, Interleukin-18