Need for liver transplantation in Indian children.
BACKGROUND
Liver transplantation (LT) is the most successful and accepted mode of therapy for failing liver in children. Pediatric LT has neither been widely attempted nor its need objectively assessed in our country.


OBJECTIVE
To assess requirement of LT in children at a tertiary care hospital.


METHODS
Data of children admitted to pediatric GE services (January 1992 to June 1997) were retrospectively analyzed. Subgroups of children with acute liver disease (ALD), chronic liver disease (CLD), neonatal cholestasis syndrome (NCS) and other etiology were evaluated for need for LT according to established criteria.


RESULTS
Of the total 301 inpatients with liver diseases assessed at our center, ALD constituted 26% (n=79), CLD 35% (n=106), NCS 27% (n=82) and miscellaneous 11% (n=34). Among ALD, 19% (n=15) had FHF and 67% (n=10) qualified for LT (INR>4.0). Of CLD, LT was warranted in 13% (2/15) cases of Wilson's disease (Wilson's score > 6) and 60% of cirrhotics (n=40/66) with decompensation. NCS comprised extrahepatic biliary atresia (EHBA) in 43, choledochal cyst in 2, paucity of intralobular bile duct (PILBD) in 2, neonatal hepatitis in 23, and was of indeterminate etiology in 12 cases. Of NCS groups, LT was the only therapeutic option in 45% (n=36) of cases (EHBA 34, choledochal cyst 2). Of 34 cases of EHBA requiring LT, 32 presented after 4 months of age and other 2 children had decompensation before four months of age. Both children with choledochal cysts had decompensated liver disease. One patient of Crigler Najjar syndrome type I had kernicterus and qualified for LT.


CONCLUSIONS
Our data shows need for LT in 30% of children with liver diseases constituted by cirrhosis (45%), biliary atresia (38%) and FHF (11%).
Mehrotra
P
P
Department of Gastroenterology (Pediatric GE), Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226 014, India.
Yachha
S K
SK
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D007231:Infant, Newborn; D008107:Liver Diseases / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000706:statistics & numerical data* / Q000639:trends; D020380:Needs Assessment / Q000458:organization & administration*; D010343:Patient Admission / Q000706:statistics & numerical data / Q000639:trends; D018579:Patient Selection; D012189:Retrospective Studies