Study of the reaction mechanism of 1,8-diazafluoren-9-one with the amino acid, L-alanine.
This paper describes the study of the reaction between 1, 8-diazafluoren-9-one (DFO) with the amino acid L-alanine in methyl alcohol. Particular interest was paid to the possible role of the solvent which appears to react with the DFO to form a hemiketal that is the reactive species. A potential reaction pathway is proposed based on the current data collected. The reaction intermediates and products were identified by a variety of spectroscopic methods including mass spectrometry (MS), nuclear magnetic resonance (NMR) spectroscopy, and X-ray crystallography.
Wilkinson
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Forensic Identification Research Section, NPS Building, Room 503, Royal Canadian Mounted Police, 1200 Vanier Parkway, Ottawa, Ontario, Canada.
D000409:Alanine / Q000737:chemistry*; D001372:Aza Compounds / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003878:Dermatoglyphics; D005554:Forensic Medicine; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D000432:Methanol / Q000737:chemistry; D009555:Ninhydrin / Q000737:chemistry; D015203:Reproducibility of Results; D012997:Solvents / Q000737:chemistry
C406982:1,8-diazafluoren-one; D001372:Aza Compounds; D007202:Indicators and Reagents; D012997:Solvents; D009555:Ninhydrin; D000409:Alanine; D000432:Methanol