title: Cataract development after trabeculectomy with mitomycin C: a 1-year study.
abstract: OBJECTIVE
  To measure cataract changes quantitatively in the crystalline lens after trabeculectomy with mitomycin C and to identify associated clinical factors.
  
  
  METHODS
  Forty-one consecutive trabeculectomy patients (41 eyes) were enrolled in this prospective study. The enrollment criteria were: phakic eye, no history of intraocular surgeries or inflammation, and no corneal opacification. The transparency of the lens was measured and analyzed by an anterior segment analysis system preoperatively and 1, 3, and 12 months postoperatively. Cataract development was correlated with clinical factors using a multivariate regression analysis.
  
  
  RESULTS
  During the first postoperative month, changes occurred primarily in the anterior segment of the lens, but later, deeper lenticular areas also started to show an increase in light scattering intensity. Multivariate regression analyses demonstrated that some clinical factors were associated with cataract development.
  
  
  CONCLUSIONS
  Slight cataractous changes develop after trabeculectomy with mitomycin C as early as 1 month postoperatively, and they gradually increase in extent and in intensity during the next 11 months.
authors.affiliation: Department of Ophthalmology, Gifu University School of Medicine, Gifu-ken, Japan.
authors.forename: L
authors.initials: L
authors.lastname: Daugeliene
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kitazawa
mesh_terms: D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002386:Cataract / Q000209:etiology* / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D011446:Prospective Studies; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin