title: Synthesis of new fluidity-enhanced amphiphilic compounds for soluble protein two-dimensional crystallization purpose.
abstract: The synthesis of new amphiphilic compounds is described. The structures are rationally designed for soluble protein two-dimensional (2D) crystallization purpose. Special attention is devoted to fluidity properties expected of resulting monolayers. A series of 13 compounds was prepared containing unsaturated, branched or fluorinated alkyl chains. Structures are either symmetrical or dissymmetrical and present a hydroxyl group as polar head, eventually complemented with two other 'secondary' hydrophilic functions.
authors.affiliation: Laboratoire de Synthèse, Bioorganique associé au CNRS, Université Louis Pasteur, Illkirch, France.
authors.forename: S
authors.initials: S
authors.lastname: Nuss
authors.forename: C
authors.initials: C
authors.lastname: Mioskowski
authors.forename: L
authors.initials: L
authors.lastname: Lebeau
mesh_terms: D003460:Crystallization; D015195:Drug Design; D007202:Indicators and Reagents / Q000138:chemical synthesis*; D008560:Membrane Fluidity; D015394:Molecular Structure; D009675:Novobiocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D012995:Solubility
chemical_list: D007202:Indicators and Reagents; D011506:Proteins; D009675:Novobiocin