No influence of adrenergic receptor polymorphisms on schizophrenia and antipsychotic response.
The adrenergic system plays an important role in psychiatric disorders such as depression and schizophrenia. Antagonism of the adrenergic receptor subtypes alpha1A and alpha2A has been found to have an antipsychotic effect. Genetic mutations in these receptors could be related to the alterations in the adrenergic system observed in psychiatric patients and to failure to respond to drug antagonism. We have studied one polymorphism in the alpha1A-adrenergic receptor (Arg492Cys) and two polymorphisms in the promoter region of the alpha2A-adrenergic receptor (-1291-C/G and -261-G/A) in a sample of clozapine-treated schizophrenic patients and controls. No clear differences were observed between the different groups suggesting that these polymorphisms did not play an important role in the aetiology of the disorder or in determining antipsychotic response.
Bolonna
A A
AA
Department of Psychological Medicine, Institute of Psychiatry, London, UK.
Arranz
M J
MJ
Munro
J
J
Osborne
S
S
Petouni
M
M
Martinez
M
M
Kerwin
R W
RW
D019943:Amino Acid Substitution; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*
C547713:ADRA1A protein, human; C547768:ADRA2A protein, human; D014150:Antipsychotic Agents; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; D003024:Clozapine