title: 4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.
authors.affiliation: Searle Research and Development, 700 Chesterfield Parkway, St. Louis, Missouri 63198, USA. john.j.talley@monsanto.com
authors.forename: J J
authors.initials: JJ
authors.lastname: Talley
authors.forename: D L
authors.initials: DL
authors.lastname: Brown
authors.forename: J S
authors.initials: JS
authors.lastname: Carter
authors.forename: M J
authors.initials: MJ
authors.lastname: Graneto
authors.forename: C M
authors.initials: CM
authors.lastname: Koboldt
authors.forename: J L
authors.initials: JL
authors.lastname: Masferrer
authors.forename: W E
authors.initials: WE
authors.lastname: Perkins
authors.forename: R S
authors.initials: RS
authors.lastname: Rogers
authors.forename: A F
authors.initials: AF
authors.lastname: Shaffer
authors.forename: Y Y
authors.initials: YY
authors.lastname: Zhang
authors.forename: B S
authors.initials: BS
authors.lastname: Zweifel
authors.forename: K
authors.initials: K
authors.lastname: Seibert
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy; D051546:Cyclooxygenase 2; D004487:Edema / Q000188:drug therapy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000097:blood / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000096926:Benzenesulfonamides
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D051546:Cyclooxygenase 2; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D007555:Isoxazoles; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases; D011994:Recombinant Proteins; D013449:Sulfonamides; C406224:valdecoxib; D000096926:Benzenesulfonamides; C496540:PTGS2 protein, human