Ly6d-L, a cell surface ligand for mouse Ly6d.
The mouse Ly6 gene family encodes proteins found in lymphocytes and other cells. Some are involved in cell activation; no ligands have been found. A ligand for Ly6d (ThB) was identified on lymphocytes using microspheres loaded with Ly6d and the cDNA isolated from a spleen/thymus library by panning on Ly6d. The Ly6d ligand (Ly6d-L) is a nonglycosylated protein of 9 kDa of broad distribution, rich in cysteine, with no discernable transmembrane sequence. Its N and C termini are on the cell surface, where it associates with a 30 kDa protein. Ly6d-L is homologous with an EGF repeat of Notch.
Apostolopoulos
J
J
Molecular Immunogenetics and Transplantation Laboratory, Austin Research Institute, Austin and Repatriation Medical Centre, Heidelberg, Victoria, Australia. j.apostolopoulos@ari.unimelb.edu.au
McKenzie
I F
IF
Sandrin
M S
MS
D000595:Amino Acid Sequence; D000818:Animals; D000950:Antigens, Ly / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D019556:COS Cells; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D018076:DNA, Complementary; D020690:GTPase-Activating Proteins; D008024:Ligands; D008214:Lymphocytes / Q000378:metabolism; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008863:Microspheres; D008969:Molecular Sequence Data; D012995:Solubility; D014162:Transfection
D000950:Antigens, Ly; D002352:Carrier Proteins; D018076:DNA, Complementary; D020690:GTPase-Activating Proteins; D008024:Ligands; D008565:Membrane Proteins; C504363:TBC1D15 protein, mouse