Inhibition of cathepsin activities by vitamin B6 derivatives.
We found that pridoxal phosphate (PLP), a coenzyme form of vitamin B6, inhibited the activity of cathepsins B, K, S and L in vitro. Cathepsins activities in cultured splenocytes were suppressed by the addition of pridoxal (PL) or pridoxine (PI) in to the culture medium. A newly synthesized artificial vitamin B6 derivative, a pridoxal propionate derivative, CLIK-164, showed selective inhibition of cathepsin O/K.
Matsui
A
A
Tokushima Bunri University, Institute for Health Sciences, Japan.
Tsuzuki
H
H
Murata
E
E
Tada
Y
Y
Asao
T
T
Katunuma
N
N
D002403:Cathepsins / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D011422:Propionates / Q000494:pharmacology; D011736:Pyridoxine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013154:Spleen / Q000201:enzymology
C406022:CLIK 164; D004791:Enzyme Inhibitors; D011422:Propionates; D002403:Cathepsins; D011736:Pyridoxine