title: 1-(2-Nitrophenyl)thiosemicarbazides: a novel class of potent, orally active non-peptide antagonist for the bradykinin B(2) receptor.
authors.affiliation: Department of Medicinal Chemistry, Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, England. ed.dziadulewicz@pharma.novartis.com
authors.forename: E K
authors.initials: EK
authors.lastname: Dziadulewicz
authors.forename: T J
authors.initials: TJ
authors.lastname: Ritchie
authors.forename: A
authors.initials: A
authors.lastname: Hallett
authors.forename: C R
authors.initials: CR
authors.lastname: Snell
authors.forename: S Y
authors.initials: SY
authors.lastname: Ko
authors.forename: R
authors.initials: R
authors.lastname: Wrigglesworth
authors.forename: G A
authors.initials: GA
authors.lastname: Hughes
authors.forename: A R
authors.initials: AR
authors.lastname: Dunstan
authors.forename: G C
authors.initials: GC
authors.lastname: Bloomfield
authors.forename: G S
authors.initials: GS
authors.lastname: Drake
authors.forename: M C
authors.initials: MC
authors.lastname: Brown
authors.forename: W
authors.initials: W
authors.lastname: Lee
authors.forename: G M
authors.initials: GM
authors.lastname: Burgess
authors.forename: C
authors.initials: C
authors.lastname: Davis
authors.forename: M
authors.initials: M
authors.lastname: Yaqoob
authors.forename: M N
authors.initials: MN
authors.lastname: Perkins
authors.forename: E A
authors.initials: EA
authors.lastname: Campbell
authors.forename: A J
authors.initials: AJ
authors.lastname: Davis
authors.forename: H P
authors.initials: HP
authors.lastname: Rang
mesh_terms: D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D065168:Bradykinin Receptor Antagonists; D002460:Cell Line; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy; D011392:Proline / Q000031:analogs & derivatives; D011869:Radioligand Assay; D051381:Rats; D043782:Receptor, Bradykinin B2; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D065168:Bradykinin Receptor Antagonists; C406222:N-(4-(2-(2-((2-dmethylaminoethyl)methylamino)ethylaminocarbonyl)pyrrolidinylsulfonyl)-2-nitrophenylamino)-N'-diphenylmethylthiourea; D043782:Receptor, Bradykinin B2; D011392:Proline; D013890:Thiourea