title: Effect of an antioxidant (quercetin) on sodium-lauryl-sulfate-induced skin irritation.
abstract: Quercetin is a bioflavonoid with antioxidant and anti-inflammatory activity. The purpose of this study was to examine the effect of quercetin on acute skin irritation, with special interest in the skin barrier function recovery. Acute irritant contact dermatitis was induced in 15 patients by 24-h occlusion of 2% sodium lauryl sulfate (SLS) (day (D) 1). The influence of application on SLS-irritated skin of topical quercetin for 5 consecutive Ds, compared to vehicle and controls, was studied. Parameters measured were transepidermal water loss (TEWL) and erythema index. Final measurements were taken on D 7 after a 1-D rest period. TEWL and the erythema index continued to rise 2 D after application of SLS and 1 D after treatment with quercetin, vehicle or controls. Both TEWL and erythema values at D 7 did not return to values before the SLS barrier disruption at all the test sites. Therefore, quercetin topically applied after induction of irritant contact dermatitis does not appear to increase the recovery of barrier function and erythema caused by SLS.
authors.affiliation: Department of Dermatology, University of Athens, A. Sygros Hospital, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Katsarou
authors.forename: E
authors.initials: E
authors.lastname: Davoy
authors.forename: K
authors.initials: K
authors.lastname: Xenos
authors.forename: M
authors.initials: M
authors.lastname: Armenaka
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D019540:Area Under Curve; D017453:Dermatitis, Irritant / Q000188:drug therapy*; D004890:Erythema / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D008297:Male; D014677:Pharmaceutical Vehicles; D010919:Placebos; D011794:Quercetin / Q000008:administration & dosage / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*; D013501:Surface-Active Agents / Q000009:adverse effects*; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D007509:Irritants; D014677:Pharmaceutical Vehicles; D010919:Placebos; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D011794:Quercetin