Quantitative collagen as a golden standard in differential diagnosing of fibrotic changes in liver tissue.
Determining a presence and degree of liver fibrosis provides means for diagnosing disease related processes. We have used two data mining methods, discriminant and regression analyses, to acquire knowledge from the data of 211 patients. We have shown and discussed that quantitative collagen has a distinguished discriminating power and can serve as a golden standard. We have additionally succeeded to obtain a formula consisting of standardised blood tests that can replace quantitative collagen. Practical implications of this is a non-invasive and cost efficient patient examination. All the results are now left for clinical evaluation and so is the current way of histopathological classifications.
Jonsson
J
J
Linköpings Universitet, Department of Biomedical Engineering, Medical Informatics, Sweden.
Babic
A
A
D001706:Biopsy; D003094:Collagen / Q000032:analysis*; D003196:Computer Graphics; D003936:Diagnosis, Computer-Assisted; D003937:Diagnosis, Differential; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology; D012015:Reference Standards
D003094:Collagen