Effects of radiation on a model of malignant glioma invasion.
We sought to characterize the effects of radiation alone and in combination with BCNU and dexamethasone on malignant glioma invasion. A model of malignant glioma invasion into a gel matrix of collagen type I was used to characterize response to radiation treatment for four malignant glioma cell lines (C6, U251, U373, A172) and nine primary human glioblastoma explants. A radiation dose dependent inhibition of invasion was noted for the C6 astrocytoma cell line but not the other cell lines or explants. Addition of BCNU and dexamethasone to radiation produced additional inhibition of invasion among the cell lines and explants but could not suppress invasion entirely.
Bauman
G S
GS
Department of Radiation Oncology, London Regional Cancer Clinic, University of Western Ontario, Canada. glenn_bauman@lrcc.on.ca
MacDonald
W
W
Moore
E
E
Ramsey
D A
DA
Fisher
B J
BJ
Amberger
V R
VR
Del Maestro
R M
RM
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001254:Astrocytoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D002330:Carmustine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004307:Dose-Response Relationship, Radiation; D005909:Glioblastoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D005910:Glioma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D066298:In Vitro Techniques; D009361:Neoplasm Invasiveness / Q000473:pathology; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects
D018906:Antineoplastic Agents, Alkylating; D002330:Carmustine