Total iron-binding capacity and serum transferrin determination under the influence of several clinical conditions.
In this study TIBC and serum-transferrin concentrations were determined by immunochemical turbidimetry, immunochemical nephelometry and radial immunodiffusion under normal and pathological clinical conditions. A total of 246 (123 male/123 female) patients were included [iron deficiency: 60 (18/42), iron overload: 56 (39/17), chronic inflammation: 47 (23/24), undefined diseases: 35 (16/19), healthy volunteers 48 (27/21)]. The data show that determination of TIBC from conversion of transferrin values using a constant factor results in significantly higher values compared to conversion with a function of first degree. For clinical practice the influence of different diseases is negligible. This study indicates that it is not possible to develop a universal algorithm for the conversion of transferrin values into TIBC.
Gottschalk
R
R
Medizinische Klinik III, Zentrum der Inneren Medizin, J.W. Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.
Wigand
R
R
Dietrich
C F
CF
Oremek
G
G
Liebisch
F
F
Hoelzer
D
D
Kaltwasser
J P
JP
D000293:Adolescent; D000328:Adult; D000368:Aged; D000753:Anemia, Refractory / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006432:Hemochromatosis / Q000097:blood; D006801:Humans; D007120:Immunochemistry; D005779:Immunodiffusion; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D012016:Reference Values; D012044:Regression Analysis; D014168:Transferrin / Q000032:analysis / Q000378:metabolism*
D014168:Transferrin; D007501:Iron