Absence of p21 WAF1 and p27 kip1 gene mutations in various feline tumours.
The coding regions of tumour suppressor and cell cycle regulatory genes p21 WAF1 and p27 Kip1 were investigated in 101 feline tumours of various types. No damaging mutations were present in the analysed areas of the genes.
Mayr
B
B
Institute for Animal Breeding and Genetics, Vienna, Austria.
Wilhelm
B
B
Reifinger
M
M
Brem
G
G
D000230:Adenocarcinoma / Q000235:genetics / Q000662:veterinary; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002280:Basal Cell Carcinoma / Q000235:genetics / Q000662:veterinary; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000662:veterinary; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D050760:Cyclin-Dependent Kinase Inhibitor p27; D016213:Cyclins / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005354:Fibrosarcoma / Q000235:genetics / Q000662:veterinary; D018219:Histiocytoma, Benign Fibrous / Q000235:genetics / Q000662:veterinary; D015674:Mammary Neoplasms, Animal / Q000235:genetics; D008545:Melanoma / Q000235:genetics / Q000662:veterinary; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000662:veterinary*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000662:veterinary; D016133:Polymerase Chain Reaction / Q000662:veterinary; D017422:Sequence Analysis, DNA; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D017931:DNA Primers; D004273:DNA, Neoplasm; D008869:Microtubule-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27