title: Stimulus frequency affects c-fos expression in the rat visual system.
abstract: We have characterised the c-fos expression patterns in various centers of the visual pathway of adult rats monocularly stimulated either by continuous or flickering light at different frequencies. Results show different immunocytochemical patterns in all centers studied, the geniculate lateral complex (LGC), superior colliculus (SC) and primary visual cortex (Oc1), depending on the physical characteristics of the stimulus (blinking frequency and light wavelength). After stimulation of the left eye, the ipsilateral pathway presents a substantial density of immunoresponsive cells, which is greater than expected with respect to the number of fibers that project ipsilaterally from the retina to the LGC and the superficial layers of the SC. A surprisingly high positive immunoresponsiveness is obtained in all cases with coherent light stimulation in the red spectrum (634 nm).
authors.affiliation: Department of Anatomy, Alicante Medical School, Miguel Hernandez University, Campus of San Juan, Alicante, Spain. correa@umh.es
authors.forename: J
authors.initials: J
authors.lastname: Correa-Lacárcel
authors.forename: M J
authors.initials: MJ
authors.lastname: Pujante
authors.forename: F F
authors.initials: FF
authors.lastname: Terol
authors.forename: V
authors.initials: V
authors.lastname: Almenar-García
authors.forename: A
authors.initials: A
authors.lastname: Puchades-Orts
authors.forename: J J
authors.initials: JJ
authors.lastname: Ballesta
authors.forename: J
authors.initials: J
authors.lastname: Lloret
authors.forename: J A
authors.initials: JA
authors.lastname: Robles
authors.forename: F
authors.initials: F
authors.lastname: Sanchez-del-Campo
mesh_terms: D000818:Animals; D000906:Antibodies; D001923:Brain Chemistry / Q000502:physiology*; D003116:Color; D015353:Eye Enucleation; D017781:Genes, Immediate-Early / Q000502:physiology; D005829:Geniculate Bodies / Q000378:metabolism; D008297:Male; D010775:Photic Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D013477:Superior Colliculi / Q000378:metabolism; D015349:Vision, Monocular / Q000502:physiology; D014793:Visual Cortex / Q000378:metabolism; D014795:Visual Pathways / Q000378:metabolism*
chemical_list: D000906:Antibodies; D016760:Proto-Oncogene Proteins c-fos