[Dihydrotestosterone therapy of men with coronary artery disease and processes of peroxidation].
In 11 men after myocardial infarction (mean age 58.8 years) influence of 3 months transdermal dihydrotestosterone (DHT) treatment on malondialdehyde (MDA), total cholesterol, HDL cholesterol, triglycerides and platelets was estimated. Decrease in MDA concentration after DHT treatment only in men with low (< 13 nmol/l) testosterone (T) level (p = 0.06) was observed. MDA concentration after 3 months DHT treatment was significantly lower in hypotestosteronemic in comparison to normotestosteronemic men (p < 0.05). Plasma lipid levels and platelet count were not affected by DHT administration. Decrease serum MDA concentration in low testosterone men with coronary artery disease may suggest that DHT treatment in this group has beneficial effects on peroxidation processes.
Barud
W
W
I Katedry i Kliniki Chorób Wewnetrznych Akademii Medycznej w Lublinie.
Wójcicka
G
G
Palusiński
R
R
Biłan
A
A
Hanzlik
J
J
D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy*; D013196:Dihydrotestosterone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D013196:Dihydrotestosterone