title: Aging-induced osteopenia in avian cortical bone.
abstract: Cortical bone loss contributes substantially to the degradation of skeletal integrity associated with aging. However, animal models that closely mimic age-related alterations in cortical bone are limited. The objective of this study was to determine if aged rooster cortical bone demonstrates phenotypic alterations similar to those observed in aged human cortical bone (i.e., expansion of the endocortical and periosteal envelopes and elevated cortical porosity). When compared with young adult roosters, aged roosters demonstrated significant expansion of the endocortical (16%) and periosteal (10%) envelopes, resulting in significantly increased cross-sectional moments of inertia. In addition, aged rooster bone demonstrated significantly elevated cortical porosity (51%) and average area of porosity (83%). We conclude that rooster bone demonstrates age-related adaptations similar to those of humans at both tissue and cellular levels, and may therefore represent a relatively useful, inexpensive animal model for investigating the mechanisms of age-related bone loss.
authors.affiliation: Department of Orthopaedic Surgery, University of Cincinnati, Cincinnati, OH 45267-0212, USA.
authors.forename: S
authors.initials: S
authors.lastname: Srinivasan
authors.forename: S A
authors.initials: SA
authors.lastname: Keilin
authors.forename: S
authors.initials: S
authors.lastname: Judex
authors.forename: R C
authors.initials: RC
authors.lastname: Bray
authors.forename: R F
authors.initials: RF
authors.lastname: Zernicke
authors.forename: T S
authors.initials: TS
authors.lastname: Gross
mesh_terms: D000367:Age Factors; D000375:Aging / Q000473:pathology*; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000473:pathology*; D002645:Chickens; D018483:Diaphyses / Q000473:pathology; D008297:Male; D010521:Periosteum / Q000473:pathology*; D014457:Ulna / Q000473:pathology*