title: Novel C-ring analogues of 20(S)-camptothecin. Part 3: synthesis and their in vitro cytotoxicity of A-, B- and C-ring analogues.
abstract: Several 5-substituted alkoxy 20(S)-camptothecin analogues having A- and B-ring substituents were prepared via semi-synthesis. Most of these compounds were found to exhibit potent anti-cancer activity based on their in vitro cytotoxicity data obtained against human tumor cell lines.
authors.affiliation: Natural Products Division, Dr. Reddy's Research Foundation, Hyderabad, AP, India. duvvuri62@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Subrahmanyam
authors.forename: V M
authors.initials: VM
authors.lastname: Sarma
authors.forename: A
authors.initials: A
authors.lastname: Venkateswarlu
authors.forename: T V
authors.initials: TV
authors.lastname: Sastry
authors.forename: A S
authors.initials: AS
authors.lastname: Srinivas
authors.forename: C V
authors.initials: CV
authors.lastname: Krishna
authors.forename: D S
authors.initials: DS
authors.lastname: Deevi
authors.forename: S A
authors.initials: SA
authors.lastname: Kumar
authors.forename: M J
authors.initials: MJ
authors.lastname: Babu
authors.forename: N K
authors.initials: NK
authors.lastname: Damodaran
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002166:Camptothecin