The effect of locally delivered controlled-release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months.
BACKGROUND
This research report evaluates clinical changes resulting from local delivery of doxycycline hyclate (DH) or traditional scaling and root planing (SRP) in a group of patients undergoing supportive periodontal therapy (SPT).


METHODS
In all, 141 patients received either DH (67) or SRP (74) treatment in sites > or =5 mm on one-half of their dentition at baseline and month 4.


RESULTS
Clinical results were determined at month 9. Baseline mean probing depth recordings were similar between the two groups (DH = 5.9 mm; SRP = 5.9 mm). Mean month 9 results showed similar clinical results for attachment level gain (DH 0.7 mm; SRP 0.8 mm) and probing depth reduction (DH 1.3 mm; SRP 1.1 mm). Percentage of sites showing > or =2 mm attachment level gain at month 9 was 24.7% in the DH group and 21.2% in the SRP group. Thirty-nine percent (39%) of DH sites and 38% of SRP sites showed > or =2 mm probing depth reduction. When treated sides of the dentition were compared to untreated sides, DH showed a difference in disease activity (> or =2 mm attachment loss) from 19.3% (untreated) to 7.2% (treated); and SRP from 14.3% (untreated) to 8.1% (treated).


CONCLUSIONS
Results show that both DH without concomitant mechanical instrumentation and SRP were equally effective as SPT in this patient group over the 9-month study period.
Garrett
S
S
Atrix Laboratories, Inc, Fort Collins, CO 80525-4417, USA.
Adams
D F
DF
Bogle
G
G
Donly
K
K
Drisko
C H
CH
Hallmon
W W
WW
Hancock
E B
EB
Hanes
P
P
Hawley
C E
CE
Johnson
L
L
Kiger
R
R
Killoy
W
W
Mellonig
J T
JT
Raab
F J
FJ
Ryder
M
M
Stoller
N
N
Polson
A
A
Wang
H L
HL
Wolinsky
L E
LE
Yukna
R A
RA
Harrold
C Q
CQ
Hill
M
M
Johnson
V B
VB
Soouthard
G L
GL
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000517:prevention & control; D010510:Periodontal Diseases / Q000517:prevention & control*; D010514:Periodontal Pocket / Q000517:prevention & control; D012008:Recurrence; D016745:Root Planing; D016037:Single-Blind Method; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004318:Doxycycline