Tuberculosis and Pelger-Huët anomaly. Case report.
We describe a patient with pulmonary tuberculosis and a rare disturbance of leukocyte segmentation, known as "Pelger-Huët anomaly", which can be observed in various diseases such as malignancies and/or infections. The importance of this association is equivocal: some authors have related to the association the particular severity of tuberculosis or the death they observed; in the case reported we noted no evidence of such a relation, notwithstanding the presence of the homozygous form of the Pelger-Huët anomaly. We suggest therefore that, when Pelger-Huët anomaly is found, an underlying disease should be searched for; the course of this illness, however, might not be affected.
Cicchitto
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G
Division of Pneumophtisiology, Clinical Laboratory, E. Morelli Hospital, Sondalo, SO, Italy.
Parravicini
M
M
De Lorenzo
S
S
Di Pisa
G
G
Malacrida
A
A
D000328:Adult; D005260:Female; D006098:Granulocytes / Q000473:pathology; D006720:Homozygote; D006801:Humans; D010381:Pelger-Huet Anomaly / Q000150:complications* / Q000235:genetics / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000473:pathology