Voltammetric study and determination of buprenorphine in pharmaceuticals.
The oxidation of buprenorphine on a carbon paste electrode has been studied using voltammetric techniques under both semi-infinite linear diffusion and hydrodynamic conditions. By applying a simple electrode pretreatment a good reproducibility of the current signal is obtained (R.S.D. = 0.85%, n = 6 for a 1.0 x 10(-5) M buprenorphine concentration). The limit of detection was found to be 2.0 x 10(-7) M. The voltammetric method developed for the determination of buprenorphine in pharmaceutical preparations was examined for its applicability to liquid and solid preparations.
García-Fernández
M A
MA
Departamento de Química Física y Analítica, Universidad de Oviedo, Asturias, Spain.
Fernández-Abedul
M T
MT
Costa-García
A
A
D000701:Analgesics, Opioid / Q000032:analysis*; D002047:Buprenorphine / Q000032:analysis*; D004058:Diffusion; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011786:Quality Control; D015203:Reproducibility of Results; D013499:Surface Properties
D000701:Analgesics, Opioid; D004364:Pharmaceutical Preparations; D002047:Buprenorphine