Fetal growth is not associated with early onset of severe retinopathy in type 1 diabetes mellitus.
Reduced fetal growth has been suggested as a possible risk factor for diabetic nephropathy. The aim of the present study was to examine whether there could be an association also with rapidly progressing severe retinopathy in younger type 1 diabetic patients. Maternal pregnancy, as well as birth parameters of 27 type 1 diabetic patients with severe retinopathy diagnosis at a median age of 25 years, were studied retrospectively. The control group consisted of 22 type 1 diabetic patients with mild background retinopathy and with similar age, age at onset, and duration of diabetes. Mothers of the subjects with severe retinopathy had a higher body mass index (P = 0.03) but similar age, blood pressure levels, and weight gain during pregnancy as those of the control group. All but four babies, two in each group, were born after 37 completed gestational weeks. There were no differences regarding birth weight or of relative birth weight corrected for gestational length. Head circumference, birth length, and placenta weight were similar. The results indicate that fetal growth is not a factor of major importance for the development of severe retinopathy in younger type 1 diabetic patients.
Agardh
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Department of Ophthalmology, Malmö University Hospital, S-205 02, Malmö, Sweden.
Herbst
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Aberg
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Agardh
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D000328:Adult; D017668:Age of Onset; D001724:Birth Weight; D001824:Body Constitution; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D011247:Pregnancy; D012189:Retrospective Studies