[Long-term evolution of C-terminal of HCV NS3 protein containing the predicted CTL epitopes in two HCV patients].
OBJECTIVE
To investigate the Long-term evolution of NS3 C-terminal protein containing the predicted CTL epitopes.


METHODS
The HLA typing was determined serologically in two chronic HCV patients. Based on this, the HLA restricted CTL epitopes were predicted by HLA binding motif. Sera samples were amplified by PCR, HCV was sequenced and translated into proteins. The changes of predicted CTL epitopes were analysed.


RESULTS
No obvious change was observed in predicted CTL epitopes in two chronic HCV patients during 5 and 3 years.


CONCLUSIONS
It demonstrated that the C-terminal of HCV NS3 protein containing the predicted CTL epitopes may have no relationship with HCV persistence.
Wang
T
T
Department of Basie Medicine, Fourth Medical University of PLA, Xi'an.
Guo
H
H
Wang
G
G
D000328:Adult; D000595:Amino Acid Sequence; D018984:Epitopes, T-Lymphocyte; D019698:Hepatitis C, Chronic / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D017361:Viral Nonstructural Proteins / Q000276:immunology*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D018984:Epitopes, T-Lymphocyte; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases