Synthesis and study of a new adenine-acridine tandem, inhibitor of exonuclease III.
A new heterodimer adenine-chain-acridine containing a mixed amido-guanidinium linker chain was synthesized. To achieve the synthesis a new method of introduction of aminoalkyl chain at position 9 of adenine was designed. The heterodimer interacts specifically with the abasic sites in DNA and inhibits the major base excision repair enzyme in Escherichia coli, Exonuclease III.
Belmont
P
P
LEDSS, Chimie Bioorganique, UMR CNRS 5616, Université Joseph Fourier, Grenoble, France.
Demeunynck
M
M
Constant
J F
JF
Lhomme
J
J
D000166:Acridines / Q000737:chemistry*; D000225:Adenine / Q000737:chemistry*; D000818:Animals; D004247:DNA / Q000737:chemistry / Q000187:drug effects; D004260:DNA Repair; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D005090:Exodeoxyribonucleases / Q000037:antagonists & inhibitors*; D006801:Humans; D051379:Mice; D014407:Tumor Cells, Cultured
D000166:Acridines; D004791:Enzyme Inhibitors; D004247:DNA; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III; D000225:Adenine