Female gamete segregation in two carriers of translocations involving 2q and 14q.
FISH, using a combination of whole-chromosome painting and telomeric probes, was used to study the gamete segregation of two female carriers of translocations involving the same chromosome arms, 2q and 14q. Preimplantation genetic diagnosis of the first polar bodies of these oocytes permitted selecting normal embryos for replacement.
Escudero
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T
The Institute for Reproductive Medicine and Science, Saint Barnabas Medical Center, Livingston, NJ-07052, USA.
Lee
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M
Sandalinas
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Munné
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S
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D001706:Biopsy; D020090:Chromosome Segregation; D002883:Chromosomes, Human, Pair 14; D002889:Chromosomes, Human, Pair 2; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008214:Lymphocytes / Q000648:ultrastructure; D009865:Oocytes / Q000648:ultrastructure; D011247:Pregnancy; D019836:Preimplantation Diagnosis; D014178:Translocation, Genetic