New tools for malaria therapy.
In the absence of vaccines, new chemotherapies are needed urgently to help in the prevention and control of malaria. A number of strategies are being followed world-wide in attempts to discover and develop them: (a) resurrecting 'forgotten' molecules; (b) developing new formulations of existing products; (c) finding ways to bypass known toxicological limitations of existing products; (d) looking for combinations of existing products; (e) discovering molecules which reverse the resistance phenotype; (f) identifying 'old' chemical entities (OCEs) for new, antimalarial, indications; (g) discovering new chemical entities (NCEs) directed towards already exploited biological targets; (h) discovering NCEs directed to novel biological targets. Examples of such strategies are given below, together with an indication of their advantages and limitations.
Gutteridge
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UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland. gutteridgew@who.ch
D015195:Drug Design; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000188:drug therapy*