[The effect of dexamethasone on the functional features in rats with Pliss lymphosarcoma transplant].
A computer-assisted method of video imaging the adhesive, permeability and thrombogenic properties of microvessels was used to study the effect of dexamethasone on the functional activity of the mesenteric microvascular endothelium in rats with Pliss' lymphosarcoma. Dexamethasone-21 Na-phosphate (0.1 mg/ml) was supplied to the desired mesenteric area and the necessary measurements were carried out. The latter showed that tumor growth was associated with microcirculation disturbances, namely, raised leukocyte adhesion to the mesenteric microvascular endothelium, microvascular permeability and thrombogenicity. Enhanced microvascular sensitivity to dexamethasone pointed to the important role played by changes in the adhesive properties of the endothelium among general paraneoplastic disorders of microcirculation.
Dubina
M V
MV
I.P. Pavlov State Medical University, St. Petersburg.
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D007962:Leukocytes / Q000187:drug effects; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008833:Microcirculation / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats
D018931:Antineoplastic Agents, Hormonal; D003907:Dexamethasone