Mortality from primary pulmonary hypertension in the United States, 1979-1996.
OBJECTIVE
To determine whether primary pulmonary hypertension mortality in the United States increased since 1979 coincident with the introduction of anorexigens.


METHODS
Examination of annual age-adjusted and age-specific primary pulmonary hypertension mortality in the United States from 1979 through 1996 and in five selected states from 1992 through 1996.


METHODS
The United States, from 1979 through 1996.


METHODS
Residents of the United States, from 1979 through 1996.


METHODS
None.


RESULTS
Annual age-adjusted mortality increased at different rates among white men and women and black men and women. The greatest increase was among black women (who also had the highest rates). Age-specific mortality showed a high rate among infants < 1 year old, a low rate in childhood, and an ascending rate throughout the remainder of life. Similar patterns were identified at the state level.


CONCLUSIONS
Primary pulmonary hypertension mortality in the United States has increased notably since 1979. Some portion of this increase may be related to the introduction of anorexigens. Improvements in diagnostic recognition may also explain part of the increase in mortality. These results need to be confirmed in a diagnosis validation study, particularly because the same mortality data suggest that the disease may be more common in the elderly than has been previously reported.
Lilienfeld
D E
DE
Department of Medicine, School of Medicine (Dr. Rubin), University of California at San Diego, USA. David.Lilienfeld@bms.com
Rubin
L J
LJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001067:Appetite Depressants / Q000008:administration & dosage / Q000009:adverse effects; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000401:mortality*; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D014481:United States / Q000453:epidemiology
D001067:Appetite Depressants