title: Biometry of the fetal heart between 10 and 17 weeks of gestation.
abstract: OBJECTIVE
  Assessment of the dimensions of the cardiac chambers and the great arteries in the human fetus may be helpful in the prenatal diagnosis of congenital heart disease. The purpose of this prospective cross-sectional study was to compile normative data in fetal cardiac measurements in early pregnancy. The structure of the fetal heart was examined in 136 normal singleton fetuses between 10 and 17 weeks of gestation.
  
  
  METHODS
  The transversal heart diameter, both ventricular dimensions, interventricular septal thickness, heart area, heart circumference, thoracic diameter, thoracic circumference and thoracic area were measured in the four-chamber view during diastole. Diameters of the pulmonary trunk and ascending aorta were obtained in the short axis and long axis view during systole. Ultrasound examinations were performed with a 5.0-MHz transvaginal and/or transabdominal phased-array sector scanner.
  
  
  RESULTS
  The four-chamber view and the cross-over of the pulmonary artery and the aorta were adequately visualized in 44% of the fetuses at 10 weeks of gestation, in 75% at 11 weeks of gestation, in 93% at 12 weeks of gestation and in 100% of the fetuses at 13-17 weeks of gestation. Before 14 weeks of gestation transvaginal sonography was superior to the transabdominal sonography in visualization of the fetal heart and great arteries. After 14 weeks of gestation transabdominal sonography accurately demonstrated the structure of the fetal heart. The ratio of right and left ventricle (RV/LV) and the ratio of the pulmonary trunk and aorta (PT/AO) were constant during this period of gestation (approximately 1.00 and 1. 10, respectively). The ratio of the cardiac and thoracic area showed only a slight increase with advancing gestational age, but with significant correlation. The fetal heart rate showed a slow decrease from 167 to 150 bpm in this period of gestation. The transversal heart diameter, both ventricular dimensions, interventricular septal thickness, heart area, cardiothoracic diameter ratio, aortic diameter and the pulmonary trunk diameter showed a highly significant linear correlation to the gestational age and the biparietal diameter.
  
  
  CONCLUSIONS
  The advancing quality of ultrasound images allows fetal echocardiography in the first and early second trimester. Our normative data could be the basis of studying the development of cardiac structures in congenital heart disease and it might be helpful in the detection of some congenital heart defects in early pregnancy.
authors.affiliation: Division of Prenatal Medicine, Department of Obstetrics and Gynecology, Medical University of Lübeck, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Gembruch
authors.forename: C
authors.initials: C
authors.lastname: Shi
authors.forename: J M
authors.initials: JM
authors.lastname: Smrcek
mesh_terms: D001011:Aorta / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D001699:Biometry / Q000379:methods*; D003430:Cross-Sectional Studies; D003971:Diastole; D004452:Echocardiography; D005260:Female; D005318:Fetal Heart / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D011651:Pulmonary Artery / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D012016:Reference Values; D012044:Regression Analysis; D013599:Systole; D016216:Ultrasonography, Prenatal / Q000379:methods