title: [Growth and differentiation of epi- and perineural structures under graded stretching].
abstract: Light and electron microscopic and ultrastructural studies of the epi- and perineurium of sciatic and tibial nerves were performed in 63 adult mongrel dogs during lengthening the femur and leg at rates of 0.5 and 1 mm a day (no more than 0.25 mm per dose) by the Il-izarov procedure. Hypertrophy of the biosynthetic apparatus, complication of intercellular and cytostromal contacts were observed in the fibroblasts of the epineurium, in the cell elements of vascular walls and perineurium during distraction. There was growth and associated changes in the volume ratios of the wall components of epineural structures, as well as new formation of structures of the intrinsic innervation apparatus of epi- and perineural sheaths. At all levels (organ, tissue, cellular, and subcellular) the new formed structures incorporated into the preexisting ones without disintegrating them, which is a characteristic feature for intercalar growth.
authors.forename: M M
authors.initials: MM
authors.lastname: Shchudlo
mesh_terms: D000818:Animals; D001852:Bone Lengthening; D002455:Cell Division; D004285:Dogs; D010525:Peripheral Nerves / Q000254:growth & development* / Q000648:ultrastructure; D010812:Physical Stimulation; D012584:Sciatic Nerve / Q000254:growth & development / Q000648:ultrastructure; D013979:Tibial Nerve / Q000254:growth & development / Q000648:ultrastructure