title: Use of clinical guidelines for treatment of anemia among hemodialysis patients.
abstract: Changing financial incentives have strongly influenced dosing patterns of recombinant human erythropoietin (rHuEPO) since its introduction in 1989. Although guidelines for prescribing rHuEPO exist, the extent to which they are adhered to is unknown. Using a retrospective cohort observational study design, the factors influencing the initial dosing of rHuEPO prescribed to 413 hemodialysis patients in 1994 were examined. Patient weight, the only recommended guideline, was not found to be a significant predictor of dosing of rHuEPO after controlling for selected patient demographic and clinical characteristics. The strongest predictor for initial rHuEPO dosing was hematocrit followed by White race (p < 0.05). Finally, each subsequent month was associated with a significantly larger initial rHuEPO dose, reflecting the general trend in increasing dose since 1991 (p < 0.001). In conclusion, despite the recent DOQI guidelines for treatment of anemia among persons with chronic renal failure, providers are not using patient weight as an independent criterion for determining dosing of rHuEPO.
authors.affiliation: Medical Technology and Practice Patterns Institute, Bethesda, Maryland, USA. mthamer@jhsph.edu
authors.forename: M
authors.initials: M
authors.lastname: Thamer
authors.forename: C M
authors.initials: CM
authors.lastname: Richard
authors.forename: J
authors.initials: J
authors.lastname: Klinkmann
authors.forename: P
authors.initials: P
authors.lastname: Ivanovich
authors.forename: G
authors.initials: G
authors.lastname: Lang
authors.forename: D J
authors.initials: DJ
authors.lastname: Cotter
mesh_terms: D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000188:drug therapy*; D001835:Body Weight; D015331:Cohort Studies; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005544:Forecasting; D006400:Hematocrit; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011994:Recombinant Proteins; D012044:Regression Analysis; D006435:Renal Dialysis; D012189:Retrospective Studies; D014168:Transferrin / Q000032:analysis; D044465:White People
chemical_list: D011994:Recombinant Proteins; D014168:Transferrin; D004921:Erythropoietin