title: Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence?
abstract: OBJECTIVE
  A long-term prospective analysis of patients with benign meningioma was undertaken to determine whether progesterone receptor (PR) status of the excised tumor has any influence on recurrence.
  
  
  METHODS
  Between 1983 and 1985, a total of 62 meningiomas in 53 patients (age range 19-79 years, mean age 55.6 years) were studied for clinical, histological, and pathological characteristics, including hormone receptor status and DNA features. Progesterone receptor status was quantified by cryostat section assay, and then factors affecting recurrence were analyzed. During 1997 all case records were reviewed to determine whether tumor had recurred in any patient, and PR status was correlated with tumor recurrence. Of the 62 tumors, 60 were benign, and of the benign tumors 29 (48%) were PR positive. Patients harboring 14 of the 60 benign tumors were lost to follow up. Of the 46 tumors included in the final analysis, 13 were recurrent (all within 5 years) and 33 were nonrecurrent. Of the 33 nonrecurrent tumors, 14 had not recurred 5 to 10 years postresection and 19 had not recurred after more than 10 years. Chi-square analysis of the results did not show an association between recurrence and patient's sex, extent of resection, histological subtype, or tumor site but did show an association between recurrence and PR negativity (p = 0.013).
  
  
  CONCLUSIONS
  The results indicate that benign meningiomas that are PR positive are less likely to recur, a finding that has prognostic and therapeutic implications.
authors.affiliation: Department of Neurosurgery, Royal Hallamshire Hospital, Sheffield, United Kingdom.
authors.forename: P E
authors.initials: PE
authors.lastname: Fewings
authors.forename: R D
authors.initials: RD
authors.lastname: Battersby
authors.forename: W R
authors.initials: WR
authors.lastname: Timperley
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000601:surgery; D008578:Meninges / Q000473:pathology; D008579:Meningioma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D011980:Receptors, Progesterone / Q000032:analysis*
chemical_list: D011980:Receptors, Progesterone