title: Atopy and pulmonary function abnormalities in children with a history of acute bronchiolitis.
abstract: To assess the relationship between acute viral bronchiolitis and subsequent development of asthma, we studied retrospectively 97 index children, aged between 9 and 14 years, and 52 controls. The bronchiolitis group showed significantly lower values for mean expiratory flow at 50% of vital capacity (MEF50) higher incidence of atopy, and were more sensitive to methacholine than were controls, even if they had not shown recurrent wheezing episodes. It is suggested that an increased incidence of atopy, bronchial hyperresponsiveness, and reduced expiratory flows may be detectable in children with a history of acute bronchiolitis, regardless of the fact that they did not develop subsequent clinical symptoms suggestive of bronchial asthma.
authors.affiliation: Servicio de Neumología, Hospital Miguel Servet, Zaragoza Spain. med0009039@nacom.es
authors.forename: J
authors.initials: J
authors.lastname: Arribas
authors.forename: C
authors.initials: C
authors.lastname: Colás
authors.forename: A
authors.initials: A
authors.lastname: Sebastián
authors.forename: R
authors.initials: R
authors.lastname: Larraga
authors.forename: J L
authors.initials: JL
authors.lastname: Olivares
authors.forename: I
authors.initials: I
authors.lastname: Pastor
authors.forename: F
authors.initials: F
authors.lastname: Duce
mesh_terms: D000208:Acute Disease; D001985:Bronchial Provocation Tests; D001988:Bronchiolitis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D016085:Bronchoconstrictor Agents; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000453:epidemiology; D015994:Incidence; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008499:Medical Records; D016210:Methacholine Chloride; D010366:Peak Expiratory Flow Rate; D012016:Reference Values; D013147:Spirometry; D014797:Vital Capacity
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride