title: Design, development and performance of a novel multidose dry-powder inhaler.
abstract: The authors describe the design and development of a breath-actuated multidose dry-powder inhaler and summarize the in vitro and in vivo data demonstrating its robustness and performance in the laboratory and during clinical use. Drugs for the treatment of asthma--including budesonide, beclomethasone dipropionate and salbutamol--when formulated with lactose powder as a carrier and dispensed via this device, have exhibited clinical efficacy and safety profiles comparable with standard pressurized metered-dose inhalers and dry-powder formulations.
authors.affiliation: R&D at Innovata Biomed Ltd, Respiratory Division of ML Laboratories plc, St Albans, UK. mparryb@aol.com
authors.forename: M
authors.initials: M
authors.lastname: Parry-Billings
authors.forename: R N
authors.initials: RN
authors.lastname: Boyes
authors.forename: L M
authors.initials: LM
authors.lastname: Clisby
authors.forename: P
authors.initials: P
authors.lastname: Braithwaite
authors.forename: S
authors.initials: S
authors.lastname: Williams
authors.forename: A E
authors.initials: AE
authors.lastname: Harper
mesh_terms: D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D004867:Equipment Design; D006801:Humans; D009330:Nebulizers and Vaporizers; D011208:Powders
chemical_list: D018927:Anti-Asthmatic Agents; D011208:Powders