title: Activity revealed in MRI of multiple sclerosis without contrast agent. A preliminary report.
abstract: Disease activity in multiple sclerosis is usually accompanied by blood-brain barrier disruption, which can be assessed with contrast-enhanced magnetic resonance imaging (MRI). This paper describes a technique that gives information about disease activity using magnetization transfer MRI. Image combination methods using follow-up scans, like the one presented here, have the potential to show MS lesions that correlate with enhancement.
authors.affiliation: Division of Medical Physics, University of Leicester, Leicester Royal Infirmary, Leicester, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Horsfield
authors.forename: M A
authors.initials: MA
authors.lastname: Rocca
authors.forename: M
authors.initials: M
authors.lastname: Cercignani
authors.forename: M
authors.initials: M
authors.lastname: Filippi
mesh_terms: D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000473:pathology*; D003287:Contrast Media; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA