title: Inhibition of cryptosporidium parvum in vitro by 9-(alkylthio)acridine derivatives.
abstract: The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.
authors.affiliation: Institute of Biotechnology, Faculty of Science, University of Granada, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Khalifa
authors.forename: M J
authors.initials: MJ
authors.lastname: Rosales
authors.forename: C
authors.initials: C
authors.lastname: Mascaro
authors.forename: J
authors.initials: J
authors.lastname: Karolak-Wojciechowska
authors.forename: N
authors.initials: N
authors.lastname: Bsiri
authors.forename: P
authors.initials: P
authors.lastname: Brouant
authors.forename: J
authors.initials: J
authors.lastname: Barbe
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D002460:Cell Line; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000187:drug effects* / Q000254:growth & development; D005243:Feces / Q000469:parasitology; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
chemical_list: D000166:Acridines; D003049:Coccidiostats