title: Histopathologic changes in retinoblastoma after chemoreduction.
abstract: OBJECTIVE
  To report the histologic findings in the eyes of two patients with bilateral retinoblastoma who underwent chemoreduction therapy and enucleation of one eye.
  
  
  METHODS
  Clinical histories were obtained for both patients. The enucleated eyes were routinely processed and sections were stained with hematoxylin and eosin.
  
  
  RESULTS
  The first patient underwent two cycles of carboplatin, vincristine, and etoposide, and the second patient underwent one cycle of carboplatin, vincristine, and etoposide before enucleation. The eyes of both patients exhibited a clinical type 3 regression pattern. Histopathologic examination showed a gliotic mass with interspersed calcifications in one eye and necrotic tumor adjacent to histologically intact retinoblastoma in the other eye.
  
  
  CONCLUSIONS
  Chemoreduction has variable effects on retinoblastoma and the clinical type 3 regression pattern has several histologic counterparts.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dithmar
authors.forename: T M
authors.initials: TM
authors.lastname: Aabert
authors.forename: H E
authors.initials: HE
authors.lastname: Grossniklaus
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002675:Child, Preschool; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007223:Infant; D012160:Retina / Q000187:drug effects / Q000473:pathology*; D019572:Retinal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012175:Retinoblastoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery