Extensive vitiligo after ganciclovir treatment of GvHD in a patient who had received donor T cells expressing herpes simplex virus thymidine kinase.
The use of donor T cells expressing a suicide gene for destruction of graft-versus-host effector cells provides a tool for alloreactivity modulation. We describe a case of extensive vitiligo that developed after ganciclovir treatment of cutaneous chronic graft-versus-host disease in a patient who had received donor T lymphocytes expressing herpes simplex virus thymidine kinase at the time of transplantation.
Aubin
F
F
Cahn
J Y
JY
Ferrand
C
C
Angonin
R
R
Humbert
P
P
Tiberghien
P
P
D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D015774:Ganciclovir / Q000009:adverse effects* / Q000627:therapeutic use; D006086:Graft vs Host Disease / Q000188:drug therapy*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male; D018139:Simplexvirus / Q000201:enzymology*; D013601:T-Lymphocytes / Q000637:transplantation*; D013937:Thymidine Kinase / Q000378:metabolism*; D014820:Vitiligo / Q000139:chemically induced*
D000998:Antiviral Agents; D013937:Thymidine Kinase; D015774:Ganciclovir