title: Signalling pathways that direct prestalk and stalk cell differentiation in Dictyostelium.
abstract: Prestalk cell differentiation in Dictyostelium is induced by DIF and two DIF-induced genes, ecmA and ecmB, have revealed the existence of multiple prestalk and stalk cell sub-types. These different sub-types are defined by the pattern of expression of subfragments derived from the ecmA and ecmB promoters. These markers have been utilised in three ways; for fate mapping in vivo, to investigate the molecular mechanisms underlying DIF signalling and to explore the relative requirement for DIF and other signalling molecules for prestalk and stalk cell differentiation in vitro. The heterogeneity of the prestalk and stalk populations seems to be reflected in differences in the cell signalling pathways that they utilise.
authors.affiliation: MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK.
authors.forename: A
authors.initials: A
authors.lastname: Early
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004023:Dictyostelium / Q000166:cytology* / Q000502:physiology*; D017125:Genes, Protozoan; D006588:Hexanones / Q000378:metabolism; D008190:Lyases / Q000502:physiology; D010088:Oxidoreductases; D010422:Pentanones / Q000378:metabolism; D015800:Protozoan Proteins / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: C075859:DIF-1 3(5)-dechlorinase; D006588:Hexanones; D010422:Pentanones; D015800:Protozoan Proteins; C055365:1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl-)-1-pentanone; C055364:1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; D010088:Oxidoreductases; D008190:Lyases