Genetics in the study of mosquito susceptibility to Plasmodium.
Within the past several years, a number of powerful genetic and genomic tools have been developed for use in research on the African malaria vector Anopheles gambiae. While these tools have been developed with a broad range of potential applications in mind, they have been particularly useful in advancing the effort to clone a set of An. gambiae genes that enable a refractory strain of this mosquito to encapsulate and kill a wide variety of different malaria parasites to which this mosquito is normally fully susceptible. This paper describes the latest progress in this map-based cloning research, which involves the collaborative contributions of a number of different laboratories in Europe and the United States.
Collins
F H
FH
Department of Biological Sciences, University of Notre Dame, IN 46556, USA. frank.h.collins.75@nd.edu
Saunders
R D
RD
Kafatos
F C
FC
Roth
C
C
Ke
Z
Z
Wang
X
X
Dymbrowski
K
K
Ton
L
L
Hogan
J
J
D000818:Animals; D000852:Anopheles / Q000235:genetics / Q000469:parasitology*; D003001:Cloning, Molecular; D004198:Disease Susceptibility; D007303:Insect Vectors; D010961:Plasmodium / Q000235:genetics / Q000472:pathogenicity*