title: In vitro activity of ABT 773, a new ketolide antibiotic, against Chlamydia pneumoniae.
abstract: The in vitro activities of ABT 773, telithromycin (HMR 3647), azithromycin, clarithromycin, erythromycin, and levofloxacin were tested against 20 strains of Chlamydia pneumoniae. The MIC at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by ABT 773 were 0.015 microg/ml (range, 0.008 to 0.015 microg/ml). ABT 773 was the most active antibiotic tested in this study.
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203-2098, USA.
authors.forename: S
authors.initials: S
authors.lastname: Strigl
authors.forename: P M
authors.initials: PM
authors.lastname: Roblin
authors.forename: T
authors.initials: T
authors.lastname: Reznik
authors.forename: M R
authors.initials: MR
authors.lastname: Hammerschlag
mesh_terms: D002690:Chlamydia Infections / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D048628:Ketolides; D008826:Microbial Sensitivity Tests
chemical_list: D048628:Ketolides; D004917:Erythromycin; C405499:cethromycin