Inhibition of dopamine transport and binding of [3H] spiperone to dopamine D2 receptor by acute Pb-toxicity in vivo.
Alterations of dopamine transport and binding of [3H] spiperone to dopamine D2 receptor following acute lead intoxication in an in vivo experimental model in adult rats imitate the acute action of Pb2+ in occupationally exposed workers or in occasional incidents of poisoning. The results show that lead-intoxication causes an increased Pb level in blood, a decrease in dopamine uptake and release in synaptosomes and affects the dopamine D2 receptor. These data show that Pb-intoxication may cause severe disturbances in the transport and receptor binding of dopamine, which is involved in the regulation of a variety of functions including locomotor activity, emotion and neuroendocrine secretion.
Sulkowski
G
G
Department of Neurochemistry, Polish Academy of Sciences, Warszawa.
Dabrowska-Bouta
B
B
Waśkiewicz
J
J
Rafałowska
U
U
D000208:Acute Disease; D000818:Animals; D001667:Binding, Competitive / Q000502:physiology; D001692:Biological Transport; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000378:metabolism*; D065127:Dopamine D2 Receptor Antagonists; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*
D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D017448:Receptors, Dopamine D2; D007854:Lead; D013134:Spiperone; D004298:Dopamine