B-1 cells: orthodox or conformist?
B-1 cells differ from conventional peripheral B cells (B-2) by anatomical location, surface marker expression, antibody repertoire and growth properties. The lineage hypothesis of B-1 cell development attributes the properties of B-1 cells to their unique origin. The induced differentiation hypothesis suggests the surface-immunoglobulin-driven development of B-1 cells from common B-1/B-2 cell progenitors. In both models self-antigen-induced signalling plays the central role in positive selection of B-1 cells. The ability of B-1 cells to be positively selected by self-antigens raises questions about the mechanism of this phenomenon.
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Laboratory of Lymphocyte Signaling, Institute for Genetics, University of Köln, Köln, D-50931, Germany.
Tarakhovsky
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D000818:Animals; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D001323:Autoantibodies / Q000096:biosynthesis; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D018956:CD5 Antigens / Q000276:immunology; D002454:Cell Differentiation; D019070:Cell Lineage; D017637:Clonal Deletion; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D010703:Phorbol Esters / Q000494:pharmacology; D011947:Receptors, Antigen, B-Cell / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D018800:Thy-1 Antigens / Q000235:genetics / Q000276:immunology
D000944:Antigens, Differentiation, B-Lymphocyte; D001323:Autoantibodies; D001324:Autoantigens; D018956:CD5 Antigens; D007143:Immunoglobulin Heavy Chains; D010703:Phorbol Esters; D011947:Receptors, Antigen, B-Cell; D018800:Thy-1 Antigens