The role of nitric oxide in apoptosis.
Nitric oxide (NO) has been shown to play important roles in modulating cell viability. Both proapoptotic and antiapoptotic functions of NO have been reported. This article discusses our current understanding on the mechanisms responsible for the dual actions of NO in regulating apoptosis and propose that one common mechanism for NO-mediated inhibition of apoptosis is the inhibition of caspases via nitrosylation.
Li
J
J
Department of Surgery, University of Pittsburgh School of Medicine, PA, USA.
Billiar
T R
TR
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology*
D009569:Nitric Oxide