title: Comparison of environmental tobacco smoke concentrations and mutagenicity for several indoor environments.
abstract: Environmental tobacco smoke (ETS) is a major source for indoor air pollution. Although ETS-caused indoor air pollution has been well studied in the developed countries, few studies have examined ETS indoor air pollution in China, which currently has the largest population of tobacco smokers. In this study, respirable-particulate (RP) from ETS-contaminated (RP-ETS) indoor air was collected and measured in 5 different indoor environments during the winter in the northwestern Liaoning Province, China. The extractable portion of RP-ETS (ERP-ETS) was obtained by dichloromethane extraction and used in the Salmonella mutagenicity assay in the presence of S9 using strains TA98, TA100, and TA1538. The percentage of RP-ETS attributable to ETS (ETS-RP) and the percentage of ERP-ETS attributable to ETS (ETS-ERP) were estimated by measuring the concentration of solanesol, an ETS marker. Comparative results in 5 different indoor environments were: (1) the concentration of RP-ETS ranged from 197.3 to 1227.6 microg/m(3) and approximately 64.7 to 92. 0% of the RP-ETS originated from ETS; (2) the concentration of ERP-ETS ranged 88.8 to 601.5 microg/m(3) and approximately 83.1 to 95.4% of the ERP-ETS originated from ETS; (3) the mutagenic potency (revertants/m(3)) of ERP-ETS ranged from 60.4 to 595.5 for TA98, from 33.7 to 312.8 for TA100, and from 49.7 to 475.2 for TA1538. The data indicate that the extent of ETS pollution and the potential health hazards of ETS to humans in the five indoor environments are in the following increasing order: rural bedrooms, urban living rooms, office rooms, restaurants, and passenger cars in that area.
authors.affiliation: Pesticide Research Center and Microbiology Department, Michigan State University, East Lansing, MI 48824, USA. zhourenq@pilot.msu.edu
authors.forename: R
authors.initials: R
authors.lastname: Zhou
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: A
authors.initials: A
authors.lastname: Haug
mesh_terms: D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000032:analysis*; D000818:Animals; D001711:Biotransformation; D002681:China; D006798:Housing; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis* / Q000493:pharmacokinetics / Q000633:toxicity*; D016273:Occupational Exposure; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000032:analysis*; D001335:Vehicle Emissions / Q000009:adverse effects / Q000032:analysis
chemical_list: D009153:Mutagens; D014028:Tobacco Smoke Pollution; D001335:Vehicle Emissions