The effect of pentylenetetrazole-kindling on the extracellular glutamate and taurine levels in the frontal cortex of rats.
We studied the extracellular concentration of glutamate and taurine in the frontal cortex of freely-moving pentylenetetrazole (PTZ) kindled rats using an in vivo microdialysis. A significant and sustained increase in the glutamate level was observed in the kindled rats, in contrast, a slight and delayed increase was observed in the non-kindled rats when the same grade seizure was induced by PTZ. The convulsive dose of PTZ administration caused a decrease in taurine levels in the controls, however, no significant changes were found in the kindled rats.
Li
Z
Z
Department of Medical Physics, School of Allied Health Science, Faculty of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka, Japan.
Yamamoto
Y
Y
Morimoto
T
T
Ono
J
J
Okada
S
S
Yamatodani
A
A
D000818:Animals; D003292:Convulsants; D005110:Extracellular Space / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism*; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000378:metabolism; D013654:Taurine / Q000378:metabolism*
D003292:Convulsants; D013654:Taurine; D018698:Glutamic Acid; D010433:Pentylenetetrazole