title: An overview of the treatment of superficial bladder cancer. Intravesical chemotherapy.
abstract: Superficial bladder cancer accounts for approximately 70% to 80% of all newly diagnosed bladder cancers. The vast majority of these cancers are transitional bladder tumors of various histologic grades (I to III). Superficial tumors include carcinoma in situ (CIS), tumors confined to the epithelium (Ta), and superficial tumors that invade the lamina propria (T1) but do not involve superficial muscle layers. The primary treatment for eradication of stage Ta and T1 bladder cancers is transurethral resection of the tumor. Many patients with superficial bladder tumors treated with endoscopic surgery alone have recurrence or tumor progression at some point in their follow-up, and, in these patients, the need for adjuvant treatment becomes a major concern.
authors.affiliation: Department of Surgery, Children's Hospital, Boston, Massachusetts.
authors.forename: J L
authors.initials: JL
authors.lastname: Duque
authors.forename: K R
authors.initials: KR
authors.lastname: Loughlin
mesh_terms: D000283:Administration, Intravesical; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002278:Carcinoma in Situ / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D015251:Epirubicin / Q000627:therapeutic use; D005009:Ethoglucid / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D016685:Mitomycin / Q000627:therapeutic use; D013852:Thiotepa / Q000627:therapeutic use; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D015251:Epirubicin; D005009:Ethoglucid; D016685:Mitomycin; D004317:Doxorubicin; D013852:Thiotepa