["Non-solvent shock agglomeration"--technology of a new alternative method for sustained release of ibuprofen. 5. Production and evaluation of retard formulations].
Conventional and prepared racemic and optically pure substances were assessed with regard to their suitability to be processed into retarded formulations by direct tabletting. In this respect conventional ibuprofen and specially granulated substances usually show only insufficient properties. Fluid bed granulated S(+)ibuprofen, however, can be suitably transformed into slow release forms by using traditional agents (above all cellulose ether); the low bulk and tapped volume of these granulates, however, is a limiting factor. Shock agglomerated ibuprofen (in particular racemic substance) offers all preconditions of dissolution in acid environment correspondingly prepared substances can cause significant release retardation in artificial intestinal juice. Moreover acceptable tablet qualities (e.g. hardness) can be guaranteed.
Möller
T
T
Institut für Pharmazeutische Technologie, Universität Graz, Austria.
Korsatko
W
W
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D007052:Ibuprofen / Q000008:administration & dosage*; D008855:Microscopy, Electron, Scanning; D011208:Powders; D012995:Solubility; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011208:Powders; D013607:Tablets; D007052:Ibuprofen