title: Does an infected peripancreatic fluid collection or abscess mandate operation?
abstract: OBJECTIVE
  To assess the treatment of peripancreatic fluid collections or abscess with percutaneous catheter drainage (PCD).
  
  
  BACKGROUND
  Surgical intervention has been the mainstay of treatment for infected peripancreatic fluid collections and abscesses. Increasingly, PCD has been used, with mixed results reported in the literature.
  
  
  METHODS
  A retrospective chart review of 1993 to 1997 was performed on 82 patients at a tertiary care public teaching hospital who had computed tomography-guided aspiration for suspected infected pancreatic fluid collection or abscess. Culture results, need for subsequent surgical intervention, length of stay, and death rate were assessed.
  
  
  RESULTS
  One hundred thirty-five aspirations were performed in 82 patients (57 male patients, 25 female patients) with a mean age of 40 years (range 17-68). The etiologies were alcohol (41), gallstones (32), and other (9). The mean number of Ranson's criteria was four (range 0-9). All patients received antibiotics. Forty-eight patients had evidence of pancreatic necrosis on computed tomography scan. Cultures were negative in 40 patients and positive in 42. Twenty-five of the 42 culture-positive patients had PCD as primary therapy, and 6 required subsequent surgery. Eleven patients had primary surgical therapy, and five required subsequent surgery. Six patients were treated with only antibiotics. The death rates were 12% for culture-positive patients and 8% for the entire 82 patients.
  
  
  CONCLUSIONS
  Historically, patients with positive peripancreatic aspirate culture have required operation. This series reports an evolving strategy of reliance on catheter drainage. PCD should be considered as the initial therapy for culture-positive patients, with surgical intervention reserved for patients in whom treatment fails.
authors.affiliation: Department of Surgery, University of Southern California School of Medicine, Los Angeles, USA.
authors.forename: N B
authors.initials: NB
authors.lastname: Baril
authors.forename: P W
authors.initials: PW
authors.lastname: Ralls
authors.forename: S M
authors.initials: SM
authors.lastname: Wren
authors.forename: R R
authors.initials: RR
authors.lastname: Selby
authors.forename: R
authors.initials: R
authors.lastname: Radin
authors.forename: D
authors.initials: D
authors.lastname: Parekh
authors.forename: N
authors.initials: N
authors.lastname: Jabbour
authors.forename: S C
authors.initials: SC
authors.lastname: Stain
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging / Q000601:surgery; D000038:Abscess / Q000000981:diagnostic imaging / Q000601:surgery*; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging / Q000601:surgery; D010182:Pancreatic Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000601:surgery; D015641:Radiography, Interventional; D012189:Retrospective Studies; D013396:Suction; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents