title: Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats.
abstract: Tinospora cordifolia is widely used in Indian Ayurvedic medicine for treating diabetes mellitus. Oral administration of an aqueous T. cordifolia root extract (TCREt) to alloxan diabetic rats caused a significant reduction in blood glucose and brain lipids. The extract caused an increase in body weight, total haemoglobin and hepatic hexokinase. The root extract also lowers hepatic glucose-6-phosphatase and serum acid phosphatase, alkaline phosphatase, and lactate dehydrogenase in diabetic rats. Thus TCREt has hypoglycaemic and hypolipidaemic effect.
authors.affiliation: Department of Biochemistry, Annamalai University, Annamalai Nagar, India.
authors.forename: P
authors.initials: P
authors.lastname: Stanely
authors.forename: M
authors.initials: M
authors.lastname: Prince
authors.forename: V P
authors.initials: VP
authors.lastname: Menon
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D004798:Enzymes / Q000097:blood / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007194:India; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010743:Phospholipids / Q000097:blood; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D004798:Enzymes; D005230:Fatty Acids, Nonesterified; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D010743:Phospholipids; D002784:Cholesterol