To be or not to be a pro-T?
Recent studies have begun to unravel some of the molecular pathways that appear to control the processes of T cell determination in the earliest thymocyte precursors. In addition, the analyses of mouse mutants with an entirely alymphoid thymus have shed light on the developmental relationship of pro-T cells and thymic dendritic cells, revealing that development of thymocytes and thymic dendritic cells can be dissociated.
Di Santo
J P
JP
Unité des Cytokines et Développement Lymphoïde, Institut Pasteur, Paris, F-75724, France. disanto@pasteur.fr
Radtke
F
F
Rodewald
H R
HR
D000818:Animals; D002135:Calcium-Binding Proteins; D002454:Cell Differentiation; D019070:Cell Lineage; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs; D006410:Hematopoiesis / Q000235:genetics; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D051798:Inhibitor of Differentiation Protein 1; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D011828:Radiation Chimera; D018121:Receptors, Cytokine / Q000502:physiology; D051880:Receptors, Notch; D012097:Repressor Proteins; D000072099:Serrate-Jagged Proteins; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology; D014157:Transcription Factors / Q000145:classification / Q000502:physiology; D014158:Transcription, Genetic
D002135:Calcium-Binding Proteins; D016207:Cytokines; D016298:Hematopoietic Cell Growth Factors; C497453:ID1 protein, human; C497455:Idb1 protein, mouse; D051798:Inhibitor of Differentiation Protein 1; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D018121:Receptors, Cytokine; D051880:Receptors, Notch; D012097:Repressor Proteins; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors