title: amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge.
abstract: In a variety of organisms, early neurogenesis requires the function of basic-helix-loop-helix (bHLH) transcription factors. For the Drosophila PNS, such transcription factors are encoded by the proneural genes (atonal and the achaete-scute complex, AS-C). We have identified a proneural gene, amos, that has strong similarity with atonal in its bHLH domain. We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS.
authors.affiliation: Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom.
authors.forename: S E
authors.initials: SE
authors.lastname: Goulding
authors.forename: P
authors.initials: P
authors.lastname: zur Lage
authors.forename: A P
authors.initials: AP
authors.lastname: Jarman
mesh_terms: D000825:Animal Structures / Q000166:cytology / Q000254:growth & development; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D002454:Cell Differentiation / Q000235:genetics; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D019281:Dimerization; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs / Q000235:genetics; D019476:Insect Proteins / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000235:genetics* / Q000378:metabolism; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins / Q000378:metabolism; D009833:Olfactory Pathways / Q000166:cytology / Q000254:growth & development; D018034:Olfactory Receptor Neurons / Q000737:chemistry* / Q000166:cytology / Q000502:physiology; D017933:Peripheral Nervous System / Q000166:cytology / Q000254:growth & development; D012333:RNA, Messenger / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013234:Stem Cells / Q000737:chemistry* / Q000166:cytology / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; C405512:Amos protein, Drosophila; C090080:Da protein, Drosophila; C082142:ato protein, Drosophila; C099964:lz protein, Drosophila