The relative frequencies of HLA-DRB1*01 alleles in the major US populations.
The frequencies of alleles in the HLA-DRB1*01 family were determined in each of five US populations from a database of 82,979 individuals. Individuals typed as DR1 (or DRB1*01) comprised between 7.6%-21.3% of the individuals in each population group. Fifty-nine DR1 individuals were randomly selected from each group and subjected to high-resolution DNA typing by polymerase chain reaction using sequence-specific oligonucleotide probes. DRB1*0101 was the most common allele in the Caucasian, Asian/Pacific Islander, and Native American groups while the DRB1*0102 allele was found in the majority of African Americans and Hispanics. DRB1*0103 was present at a similar frequency in all populations. DRB1*0104, DRB1*0105, and DRB1*0106 alleles were not observed.
Collins
M M
MM
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
Tang
T
T
Slack
R
R
Sintasath
D
D
Hartzman
R J
RJ
Ng
J
J
Hurley
C K
CK
Ng
J
J
Hurley
C K
CK
D000483:Alleles; D005787:Gene Frequency; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D044469:Racial Groups / Q000235:genetics*; D014481:United States
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains