title: Effect of bilateral ovariectomy and ovarian steroid hormones on the antioxidant systems and plasma malondialdehyde levels in Wistar rats.
abstract: We studied in the Wistar rat the effect of bilateral ovariectomy and of the administration of estradiol (E2) alone or together with medroxyprogesterone (MPA) on the lipid peroxidation (MDA) and the enzymatic (SOD and catalase) and non-enzymatic (vitamins A and E) antioxidant systems. At 15 days after castration, we observed no variations in the lipid peroxidation levels (MDA), with there being a slight increase in vitamins A and E (p<0.05), catalase (p<0.01), and SOD (n.s.) activity. The addition of estradiol led to a decline (n.s.) in the MDA values and in the catalase and SOD activity, with no modification of the vit. A and E concentrations. The combined (E2+MPA) therapy did not modify the results obtained with E2 alone, although the catalase decline did now reach significance (p<0.05).
authors.affiliation: Department of Obstetrics and Gynaecology, School of Medicine, University of Extremadura, Badajoz, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez-Zubeldia
authors.forename: R
authors.initials: R
authors.lastname: Hernandez
authors.forename: J
authors.initials: J
authors.lastname: Viguera
authors.forename: J J
authors.initials: JJ
authors.lastname: Arbues
authors.forename: A
authors.initials: A
authors.lastname: Aparicio
authors.forename: J C
authors.initials: JC
authors.lastname: Millán
mesh_terms: D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors / Q000097:blood; D004338:Drug Combinations; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000097:blood; D008525:Medroxyprogesterone / Q000494:pharmacology*; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology*; D016877:Oxidants / Q000037:antagonists & inhibitors*; D045167:Progesterone Congeners / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000097:blood; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D004338:Drug Combinations; D008054:Lipid Peroxides; D016877:Oxidants; D045167:Progesterone Congeners; D014801:Vitamin A; D014810:Vitamin E; D004958:Estradiol; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D008525:Medroxyprogesterone