title: Roxatidine in duodenal ulcer.
abstract: Roxatidine acetate is a new H2-receptor antagonist. A randomized double-blind clinical trial in fifty-three patients with endoscopically proven duodenal ulcers > 5 mm in diameter was undertaken to compare safety and efficacy of roxatidine with that of ranitidine. Twenty-six patients received roxatidine (75 mg bid) while 27 patients received ranitidine (150 mg bid) for 4 weeks. One patient in each group did not come for follow up. Roxatidine and ranitidine had comparable ulcer healing rates (22/25 vs 22/26); roxatidine, however, resulted in greater reduction in the number and severity of night time pain episodes (p < 0.05). No adverse event was reported during 4 weeks of treatment with roxatidine. Thus roxatidine achieves the primary therapeutic goal of relief of pain better than ranitidine.
authors.affiliation: Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.
authors.forename: C M
authors.initials: CM
authors.lastname: Habibullah
authors.forename: M A
authors.initials: MA
authors.lastname: Habeeb
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006635:Histamine H2 Antagonists / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010880:Piperidines / Q000008:administration & dosage*; D011899:Ranitidine / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D006635:Histamine H2 Antagonists; D010880:Piperidines; D011899:Ranitidine; C053742:roxatidine acetate