title: The influence of repeated prestressors on single stress response in rats.
abstract: The effect of various stressors of different intensity applied in random order before the final single immersion restraint stress was tested in two inbred rat strains, isoprenaline-sensitive and isoprenaline-resistant. The isoprenaline-sensitive strain revealed higher incidence of heart lesions after this single acute stress and low incidence of gastric lesions. The isoprenaline-resistant strain had the opposite characteristics. These differences were constantly reproducible when this strong stressor was used. After prestress by different stressors (tail-flick, ether anaesthesia, Porsolt swimming stress) at different time schedules, the incidence of gastric ulcer lesions, the weight of organs (heart, adrenals, spleen) changed substantially in isoprenaline-sensitive rats only. The most important result was reversal of the extent of gastric lesions. The isoprenaline-sensitive strain revealed more lesions than the isoprenaline-resistant one. The repeated different prestressors mainly changed the reactivity of animals, isoprenaline-sensitive rats becoming more similar to isoprenaline-resistant rats. These findings urged us to interpret carefully the results obtained in stress research with different and multiple stressors both in animals and humans.
authors.affiliation: Department of Normal, Pathological and Clinical Physiology, Charles University, 3rd Faculty of Medicine, Prague, Czech Republic. yamamoto@lf3.cuni.cz
authors.forename: A
authors.initials: A
authors.lastname: Yamamotová
authors.forename: M
authors.initials: M
authors.lastname: Starec
authors.forename: H
authors.initials: H
authors.lastname: Rasková
authors.forename: R
authors.initials: R
authors.lastname: Rokyta
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004351:Drug Resistance; D006321:Heart / Q000033:anatomy & histology; D006339:Heart Rate / Q000502:physiology; D007101:Immersion; D007545:Isoproterenol / Q000494:pharmacology; D009929:Organ Size; D017288:Pain Threshold / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013154:Spleen / Q000033:anatomy & histology; D013276:Stomach Ulcer / Q000209:etiology; D013312:Stress, Physiological / Q000097:blood / Q000150:complications / Q000209:etiology* / Q000503:physiopathology*; D013550:Swimming
chemical_list: D000318:Adrenergic beta-Agonists; D001786:Blood Glucose; D007545:Isoproterenol