Serum procalcitonin and proinflammatory cytokines in a patient with acute severe leptospirosis.
Leptospirosis is a zoonosis, with clinical manifestations ranging from the imperceptible to severe, potentially fatal renal and liver failure accompanied by haemorrhage and jaundice. In this case report of a patient with severe leptospirosis, serum levels of procalcitonin decreased ahead of any obvious clinical improvement, and thus may be useful as a prognostic marker. Levels of soluble IL-2 receptor were very high and correlated well with the clinical course.
Petros
S
S
Universität Leipzig, Medizinische Klinik I, Abteilung für Intensivmedizin, Germany.
Leonhardt
U
U
Engelmann
L
L
D000208:Acute Disease; D000372:Agglutination Tests; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015415:Biomarkers; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007118:Immunoassay; D015850:Interleukin-6 / Q000097:blood; D007919:Leptospira / Q000276:immunology; D007922:Leptospirosis / Q000188:drug therapy / Q000276:immunology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011498:Protein Precursors / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000097:blood; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000900:Anti-Bacterial Agents; D015415:Biomarkers; C000606589:CALCA protein, human; D016207:Cytokines; D015850:Interleukin-6; D011498:Protein Precursors; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide