The Gerhard Zbinden memorial lecture. Are environmental chemicals affecting the integrity or expression of the human genome?
Toxicology is entering a new phase wherein powerful model systems will become available to predict toxicity and to study mechanisms of action. For these new techniques to achieve their potential it will be necessary for toxicologists to pose precise questions, and to design experiments to answer those questions unequivocally. These needs are illustrated by recent examples from the study of endocrine disruption in mammals and the validation of accelerated (transgenic) rodent cancer bioassays.
Ashby
J
J
Central Toxicology Laboratory, AstraZeneca, Alderley Park, Cheshire, UK. john.ashby@ctl.zeneca.com
D000818:Animals; D004785:Environmental Pollutants / Q000009:adverse effects*; D015870:Gene Expression / Q000187:drug effects*; D015894:Genome, Human; D006801:Humans; D011960:Receptors, Estrogen / Q000187:drug effects; D012107:Research Design; D013329:Structure-Activity Relationship; D014116:Toxicology / Q000639:trends*
D004785:Environmental Pollutants; D011960:Receptors, Estrogen