Antioxidant stobadine and neurobehavioural development of the rat offspring.
Stobadine (STO) is a potential neuro- and cardioprotective drug with high antioxidative properties. The presented study investigated the effects of oral STO administration (5, 15 and 50 mg/kg/d) during pregnancy and lactation to dams on neurobehavioural development of their offspring (body growth and maturation, sensory functions, neuromotor and reflex development, levels of activity and emotional reactivity, memory and learning processes). The results of our experiments showed that long-term administration of STO had no adverse effects on the course of pregnancy and lactation in dams and on the neurobehavioural development of offspring.
Dubovický
M
M
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava. exfadubm@savba.savba.sk
Ujházy
E
E
Kovacovský
P
P
Rychlík
I
I
Navarová
J
J
Jansák
J
J
D000161:Acoustic Stimulation; D000284:Administration, Oral; D000375:Aging / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002243:Carbolines / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007774:Lactation; D007858:Learning / Q000187:drug effects*; D008098:Litter Size / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects*; D013216:Reflex, Startle / Q000187:drug effects
D000975:Antioxidants; D002243:Carbolines; C100106:dicarbine