title: Association of interleukin-1 gene polymorphisms with Alzheimer's disease.
abstract: Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades.
authors.affiliation: Department of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland.
authors.forename: J A
authors.initials: JA
authors.lastname: Nicoll
authors.forename: R E
authors.initials: RE
authors.lastname: Mrak
authors.forename: D I
authors.initials: DI
authors.lastname: Graham
authors.forename: J
authors.initials: J
authors.lastname: Stewart
authors.forename: G
authors.initials: G
authors.lastname: Wilcock
authors.forename: S
authors.initials: S
authors.lastname: MacGowan
authors.forename: M M
authors.initials: MM
authors.lastname: Esiri
authors.forename: L S
authors.initials: LS
authors.lastname: Murray
authors.forename: D
authors.initials: D
authors.lastname: Dewar
authors.forename: S
authors.initials: S
authors.lastname: Love
authors.forename: T
authors.initials: T
authors.lastname: Moss
authors.forename: W S
authors.initials: WS
authors.lastname: Griffin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D007375:Interleukin-1