Association of interleukin-1 gene polymorphisms with Alzheimer's disease.
Interleukin-1 (IL-1) is markedly overexpressed in Alzheimer's disease. We found the IL-1A 2,2 genotype in 12.9% of 232 neuropathologically confirmed Alzheimer's disease patients and 6.6% of 167 controls from four centers in the United Kingdom and United States (odds ratio, 3.0; controlled for age and for ApoE [apolipoprotein E] genotype). Homozygosity for both allele 2 of IL-1A and allele 2 of IL-1B conferred even greater risk (odds ratio, 10.8). IL-1 genotypes may confer risk for Alzheimer's disease through IL-1 overexpression and IL-1-driven neurodegenerative cascades.
Nicoll
J A
JA
Department of Neuropathology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, Scotland.
Mrak
R E
RE
Graham
D I
DI
Stewart
J
J
Wilcock
G
G
MacGowan
S
S
Esiri
M M
MM
Murray
L S
LS
Dewar
D
D
Love
S
S
Moss
T
T
Griffin
W S
WS
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D007375:Interleukin-1