Importance of a pyrogallol-type structure in catechin compounds for apoptosis-inducing activity.
Several catechin compounds were examined for their ability to induce apoptosis in human histiocytic lymphoma U937 cells. Catechins with a pyrogallol-type structure in a B-ring induced apoptosis and a 3-O-gallate group in cis-relationship to the B ring enhanced the activity. Catechins without a pyrogallol-type structure in a molecule lacked activity. These data suggest the important role of the 5'(3')-hydroxyl group in the B-ring and that a pyrogallol-type structure in a molecule is a minimum requirement for apoptosis induction by catechin compounds.
Saeki
K
K
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
Hayakawa
S
S
Isemura
M
M
Miyase
T
T
D017209:Apoptosis / Q000187:drug effects*; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D015394:Molecular Structure; D011748:Pyrogallol / Q000032:analysis*; D020298:U937 Cells
D011748:Pyrogallol; D002392:Catechin