Experimental Goettingen minipig and beagle dog as two species used in bioequivalence studies for clinical pharmacology (5-aminosalicylic acid and atenolol as model drugs).
Due to proven similarities in biotransformation between man and minipig, minipig seems to be the experimental animal of choice for preclinical pharmacokinetic studies when an experiment with a drug exhibiting a great first pass bioelimination (like 5-aminosalicylic acid) is to be realised. On the other hand, both minipig and dog may be suitable species for a pharmacokinetic study with a drug characterized by a small extent of first pass biotransformation (like atenolol).
Kvetina
J
J
Institute of Experimental Biopharmaceutics, Joint Laboratory of Czech Academy of Sciences and PRO.MED.CS, Hradec Králové, Czech Republic. uebf@hk.cesnet.cz
Svoboda
Z
Z
Nobilis
M
M
Pastera
J
J
Anzenbacher
P
P
D000818:Animals; D019540:Area Under Curve; D001262:Atenolol / Q000097:blood / Q000493:pharmacokinetics*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D006801:Humans; D019804:Mesalamine / Q000097:blood / Q000493:pharmacokinetics*; D013552:Swine; D013556:Swine, Miniature; D013810:Therapeutic Equivalency
D019804:Mesalamine; D001262:Atenolol