title: A new quantitative method for the diagnosis of right ventricular hypertensive disorders in 3 dimensions.
abstract: A new 3-dimensional (3D) method is described for the diagnosis of normal and hypertensive right ventricular (RV) conditions on the basis of similarity of RV structure to models of normal average shape or hypertensive average shape. Right ventricular quantification in multiple views (coronal, sagittal, and transverse) was obtained by measuring tangent angle differences (TADs) between RV tracings and average shapes at 128 points around the ventricular contour in each view. The TAD measurements of all views were then combined to quantify the closest 3D fit of the ventricle to a normal or hypertensive model.
  
  
  RESULTS
  In 24 lamb casts measured in vitro, an accurate diagnosis was obtained in 11 of 12 normotensive casts (specificity 92%) and 11 of 12 hypertensive casts (sensitivity 92%).
  
  
  CONCLUSIONS
  Accurate 3D diagnosis of in vitro normotensive and hypertensive RV conditions can be realized by measuring the TADs between the ventricle and average-shaped models.
authors.affiliation: Department of Cardiology, Children's Hospital, Boston, Mass, USA.
authors.forename: E N
authors.initials: EN
authors.lastname: Marcus
authors.forename: R A
authors.initials: RA
authors.lastname: Munoz
authors.forename: G
authors.initials: G
authors.lastname: Palacio
authors.forename: D L
authors.initials: DL
authors.lastname: Wessel
authors.forename: S D
authors.initials: SD
authors.lastname: Colan
mesh_terms: D000818:Animals; D016319:Corrosion Casting; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging*; D017380:Hypertrophy, Right Ventricular / Q000145:classification / Q000000981:diagnostic imaging* / Q000209:etiology; D066298:In Vitro Techniques; D008962:Models, Theoretical; D015203:Reproducibility of Results; D012756:Sheep; D012826:Silicone Elastomers
chemical_list: D012826:Silicone Elastomers