title: Antifungal and larvicidal cordiaquinones from the roots of Cordia curassavica.
abstract: In addition to the known cordiaquinones A and B, two novel meroterpenoid naphthoquinones, named cordiaquinones J and K, have been isolated from the roots of Cordia curassavica. Their structures were elucidated by spectrometric methods including EI, D/CI mass spectrometry, 1H, 13C and 2D-NMR experiments. The four naphthoquinones demonstrated antifungal activities against Cladosporium cucumerinum, Candida albicans and toxic properties against larvae of the yellow fever-transmitting mosquito Aedes aegypti.
authors.affiliation: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, BEP, Ecole de Pharmacie, Switzerland.
authors.forename: J R
authors.initials: JR
authors.lastname: Ioset
authors.forename: A
authors.initials: A
authors.lastname: Marston
authors.forename: M P
authors.initials: MP
authors.lastname: Gupta
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002963:Cladosporium / Q000187:drug effects; D005659:Fungicides, Industrial / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D005659:Fungicides, Industrial; D007306:Insecticides; D009285:Naphthoquinones; C411134:cordiaquinone J; C411133:cordiaquinone K