Ah receptor ligands and tumor promotion: survival of neoplastic cells.
A number of agonists of the aryl hydrocarbon or dioxin receptor (AhR) are potent tumor promoters in rodent liver. The prototype compound is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Tumor promotion by TCDD is likely to be AhR-mediated. Tumor promoters may affect the rate of division, terminal differentiation or death (apoptosis) of tumor precursor cells. The present paper reviews some of the effects of TCDD on liver cell homeostasis that have been observed under diverse experimental settings and discusses some of the possible underlying mechanisms.
Schwarz
M
M
Institute of Toxicology, University of Tübingen, Wilhelmstr. 56, D-72074, Tübingen, Germany. michael.schwarz@uni-tuebingen.de
Buchmann
A
A
Stinchcombe
S
S
Kalkuhl
A
A
Bock
K
K
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002273:Carcinogens / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D008024:Ligands; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008113:Liver Neoplasms / Q000139:chemically induced*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D018336:Receptors, Aryl Hydrocarbon / Q000819:agonists* / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*
D002273:Carcinogens; D008024:Ligands; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon; D013723:Teratogens