title: Determination of Lansoprazole in pharmaceutical dosage forms by two different spectroscopic methods.
abstract: Two different ultraviolet (UV) spectroscopic methods were developed for determination of Lansoprazole in pharmaceutical dosage forms. The solutions of the standard and the sample were prepared in 0.1 M NaOH and phosphate buffer pH 6.6. Both UV spectrophotometric and derivative spectroscopic techniques were applied. Second-order derivative spectra were generated between 200 and 400 nm at N = 9, deltalambda = 31.5. The linear range for the UV spectrophotometric method was 3.0-25.0 microg ml(-1) and that for the derivative spectroscopic method was 0.5-25.0 microg ml(-1). The developed methods were applied to three different pharmaceutical preparations. The percentage recovery was 100.2%.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ozaltín
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents / Q000032:analysis*; D002138:Calibration; D002214:Capsules / Q000737:chemistry; D005069:Evaluation Studies as Topic; D005079:Excipients / Q000737:chemistry; D064747:Lansoprazole; D009853:Omeprazole / Q000031:analogs & derivatives* / Q000032:analysis; D012044:Regression Analysis; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000191:economics / Q000379:methods*
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D002214:Capsules; D005079:Excipients; D064747:Lansoprazole; D009853:Omeprazole