Brugada syndrome and sudden cardiac death in children.
In five children from the same family who died after unexplained cardiac arrest, Brugada syndrome syndrome was suspected based on the transient manifestation of the typical electrocardiogram pattern in one of them. A mutation in the cardiac sodium-channel confirmed the diagnosis of Brugada syndrome, which suggests that this disease may cause sudden death in children.
Priori
S G
SG
Napolitano
C
C
Giordano
U
U
Collisani
G
G
Memmi
M
M
D002037:Bundle-Branch Block / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006323:Heart Arrest / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D062554:NAV1.5 Voltage-Gated Sodium Channel; D010375:Pedigree; D015222:Sodium Channels / Q000235:genetics; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000175:diagnosis / Q000235:genetics
D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels