title: Multiple endocrine neoplasia type 1 in a crossbred dog.
abstract: Multiple endocrine neoplasia type 1 was diagnosed in a 12-year-old male crossbred dog. Relevant history included polyuria and polydipsia of four months' duration. Physical examination revealed abdominal enlargement, seborrhoea and polypnoea. Diagnostic tests indicated hypercalcaemia, elevated serum alkaline phosphatase and alanine aminotransferase, an exaggerated response to adrenocorticotropic stimulation of the adrenal gland, lack of cortisol suppression with a low dose dexamethasone suppression test and suppression of cortisol secretion with a high dose dexamethasone test. An enlarged right parathyroid gland was removed surgically and confirmed histopathologically to be a parathyroid adenoma. The pituitary-dependent hyperadrenocorticism was treated successfully with mitotane for 14 months before the patient was euthanased for an unrelated problem.
authors.affiliation: Department of Veterinary Clinical Sciences, Massey University, Palmerston North, New Zealand.
authors.forename: M C
authors.initials: MC
authors.lastname: Walker
authors.forename: B R
authors.initials: BR
authors.lastname: Jones
authors.forename: W G
authors.initials: WG
authors.lastname: Guildford
authors.forename: H M
authors.initials: HM
authors.lastname: Burbidge
authors.forename: M R
authors.initials: MR
authors.lastname: Alley
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D008297:Male; D008939:Mitotane / Q000627:therapeutic use; D018761:Multiple Endocrine Neoplasia Type 1 / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010282:Parathyroid Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008939:Mitotane