title: [The structure of the white pulp of the spleen and the peripheral blood indices in rats under increased muscle activity].
abstract: The white pulp structure was studied in rat spleen white pulp in conditions of increased muscle activity as well as certain parameters of peripheral blood. 36 male outbred albino rats were involved. Experimental rats were subjected to the increased physical load (everyday swimming seances lasting from 10 to 40 hrs during 4 weeks). The number of erythrocytes, leukocytes and level of hemoglobin were determined in peripheral blood. Perimeter squares and density of lymphoid nodules (LN) and marginal zone (MZ) as well as LN minimal and maximal diameter and MZ minimal and maximal width were determined in histological sections prepared at the level of the organ portae using TV-computer set. Besides, marginal sinuses width were measured in nine sites in every LN as well as the capsule thickness in three sites and at the level of portae. The data obtained indicate that increased muscle activity causes reorganization of red and white pulp in the direction of growth of the red pulp square which is associated with the increase of erythropoietic function. The appearance of lymphoid nodules with germination centres indicates lymphocytopoietic function intensification while the significant increase of marginal zone morphometric parameters witnesses its participant in primary immune response. High correlation between certain blood indexes and the parameters of lymphoid nodules and marginal zones supports these data.
authors.affiliation: Department of Anatomy and Sporting Morphology, P. F. Lesgaft Academy of Physical Culture, St. Petersburg.
authors.forename: O N
authors.initials: ON
authors.lastname: Gruzdeva
authors.forename: V N
authors.initials: VN
authors.lastname: Chikhman
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004906:Erythrocyte Count; D006454:Hemoglobins / Q000032:analysis*; D007958:Leukocyte Count; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009929:Organ Size / Q000502:physiology; D051381:Rats; D013154:Spleen / Q000033:anatomy & histology*; D013550:Swimming; D013997:Time Factors; D015430:Weight Gain / Q000502:physiology
chemical_list: D006454:Hemoglobins