title: The investigations into the interferon-like activity of Polygonum L. genus.
abstract: The interferon inducing abilities of eleven ethanolic extracts obtained from nine taxons of Polygonum L. genus, were tested in the cell culture of monkey kidney. The extracts from the herb of Polygonum amphibium L. and the rhizome and fruit of Polygonum bistorta L. induced a substance showing an interferon-like activity. Biological activity studies showed that the protective titre (the highest dilution which protected cells by 50% against virus infection) of the interferon-like materials was 1:10-1:15.
authors.affiliation: Department of Pharmaceutical Botany, Medical University, Lublin, Poland.
authors.forename: H D
authors.initials: HD
authors.lastname: Smolarz
authors.forename: T
authors.initials: T
authors.lastname: Skwarek
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D029822:Enterovirus B, Human / Q000187:drug effects; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D019664:Polygonaceae / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D007369:Interferon Inducers; D010936:Plant Extracts; D007372:Interferons