Striatal dopamine in early-onset primary torsion dystonia with the DYT1 mutation.
Although nigrostriatal dopaminergic dysfunction has been suggested in early onset primary torsion dystonia (PTD) with the DYT1 mutation, the actual status of brain dopamine (DA) is unknown. In a DYT1 mutation-positive autopsy patient with PTD, we found that nigral cellularity was normal and that subregional striatal DA levels were within the control range, except for those in the rostral portions of the putamen and caudate nucleus (50% to 54% of control means). Our data suggest that the DYT1 mutation is not associated with significant damage to the nigrostriatal DA system, in keeping with the absence of parkinsonism and levodopa response in this disorder.
Furukawa
Y
Y
Movement Disorders Research Laboratory, Centre for Addiction and Mental Health, The Clarke Division, Toronto, Ontario, Canada. Yoshiaki_Furukawa@camh.net
Hornykiewicz
O
O
Fahn
S
S
Kish
S J
SJ
D017668:Age of Onset; D001483:Base Sequence; D002648:Child; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis*; D004422:Dystonia Musculorum Deformans / Q000235:genetics* / Q000378:metabolism*; D006719:Homovanillic Acid / Q000032:analysis*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics
D004298:Dopamine; D006719:Homovanillic Acid