Hematological toxicity associated with tiazofurin-influence on erythropoiesis.
In this study hematological toxicity was analyzed after the single and repeated applications of tiazofurin (TZF). Cellularity of bone marrow, spleen and peripheral blood was examined, spanning the period of fifty days after the initial application. Analysis of hematological parameters was performed by slightly modified conventional techniques. The fraction of erythroid series was monitored during the experiment. Presented data describe kinetics of damage and recovery of hemopoietic tissue. Our results indicate that the effect of tiazofurin on cellularity of bone marrow and spleen and on erythropoiesis is reversible and dose dependent within tested dose range and therapeutic regimes. Twenty days after the application normal function of hemopoietic tissues was restored. This approach and results can be useful in defining the timing for sequencing and combination therapy with tiazofurin.
Vranić
V
V
Laboratory for Radiobiology and Molecular Genetics, The 'Vinca' Institute for Nuclear Sciences, Vinca, Mike Alasa 14, PO Box 522, Yu-11001, Belgrade, Yugoslavia.
Savovski
K
K
Dedović
N
N
Dimitrijević
B
B
D000505:Alopecia / Q000139:chemically induced; D000740:Anemia / Q000139:chemically induced; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D001772:Blood Cell Count / Q000187:drug effects; D001773:Blood Cells / Q000166:cytology / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects; D002100:Cachexia / Q000139:chemically induced; D002452:Cell Count / Q000187:drug effects; D003128:Coma / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004920:Erythropoiesis / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000633:toxicity; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013163:Splenomegaly / Q000139:chemically induced; D015996:Survival Rate
D000964:Antimetabolites, Antineoplastic; D006454:Hemoglobins; D012254:Ribavirin; C033706:tiazofurin