title: Do early adverse experiences establish a cognitive vulnerability to depression on exposure to mirroring life events in adulthood?
abstract: BACKGROUND
  We pursue a 'lock and key' hypothesis which posits that early adverse events ('locks') create an increased vulnerability to depression in the face of mirroring life events ('keys') in adulthood. Here we examine whether any such vulnerability links are cognitively mediated.
  
  
  METHODS
  We study a sample of 96 clinically depressed patients who reported an identifiable 'cognitive schema' being activated when depressed. We examine for significant associations between early adverse events and later precipitants to the patients' depression, and then assess the extent to which any identified links are cognitively mediated.
  
  
  RESULTS
  Qualitative analyses suggested quite strong associations between early childhood experiences and identified schemas, while the quantitative analyses identified few links.
  
  
  CONCLUSIONS
  These contrasting results may present a challenge to the hypothesis or reflect methodological limitations, and we therefore detail some of the complexities involved in identifying cognitive schemas.
authors.affiliation: School of Psychiatry, University of New South Wales and Mood Disorders Unit, Prince of Wales Hospital, Randwick, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Parker
authors.forename: G
authors.initials: G
authors.lastname: Gladstone
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: K
authors.initials: K
authors.lastname: Wilhelm
authors.forename: K
authors.initials: K
authors.lastname: Roy
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D003071:Cognition; D003865:Major Depressive Disorder / Q000523:psychology*; D006801:Humans; D008016:Life Change Events; D013997:Time Factors