[Response of immune system and lymphoid tissue of respiratory and gastrointestinal organs to space flight factors].
The studies demonstrated that gamma-radiation drastically enhanced destructive processes and suppressed the mitotic activity of lymphocytes in the thymus and spleen. This resulted in the altered morphological picture of immune organs: the inversion of layers occurred in the thymus, the splenic white pulp increased by three times, lymphoid nodules with germinating centers disappeared, the marginal area became thinner. Following gamma-radiation, restorative processes in the thymus and spleen were noticeable just on day 3 and 7, respectively. However, the cell composition of murine immune organs failed to achieve control values by day 60 after exposure. Examining the responses of respiratory and digestive lymphoid tissue to acetaldehyde and drinking water organisms indicated that as the concentration of an acting agent and the time of exposure increased, there was lymphocytopoietic inhibition in the lymphoid formations whereas its small doses activated a local immune response.
Sapin
M R
MR
Erofeeva
L M
LM
Grigorenko
D E
DE
D000818:Animals; D003359:Cosmic Radiation / Q000009:adverse effects*; D004064:Digestive System / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects; D007107:Immune System / Q000473:pathology / Q000528:radiation effects*; D008214:Lymphocytes / Q000473:pathology / Q000528:radiation effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000276:immunology / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012137:Respiratory System / Q000276:immunology* / Q000473:pathology / Q000528:radiation effects; D013026:Space Flight; D013154:Spleen / Q000473:pathology / Q000528:radiation effects; D013950:Thymus Gland / Q000473:pathology / Q000528:radiation effects