title: [Planning sample size in ophthalmologic studies].
abstract: An essential aspect in the cooperation of clinic and biometry consists in designing of studies, e.g. during the preparation of grant applications or for review by official drug surveillance institutions. A central aspect in study planning is the design-adequate and well-documented prediction of sample size, which should be recommended for any intended study. Based on several examples for sample size planning in study designs, which are of common relevance for ophthalmology, guidelines are derived to enable clinical researchers to perform sample size planning on their own. The latter can be based on the various available software packages for sample size prediction.
authors.affiliation: Koordinierungszentrum für Klinische Studien, Universität Mainz. krummi@imsd.uni-mainz.de
authors.forename: F
authors.initials: F
authors.lastname: Krummenauer
authors.forename: B
authors.initials: B
authors.lastname: Dick
authors.forename: O
authors.initials: O
authors.lastname: Schwenn
authors.forename: N
authors.initials: N
authors.lastname: Pfeiffer
mesh_terms: D015982:Bias; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D017408:Guidelines as Topic; D006801:Humans; D009885:Ophthalmology / Q000706:statistics & numerical data*; D012107:Research Design; D018401:Sample Size