1-(2-Nitrophenyl)thiosemicarbazides: a novel class of potent, orally active non-peptide antagonist for the bradykinin B(2) receptor.
Dziadulewicz
E K
EK
Department of Medicinal Chemistry, Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, England. ed.dziadulewicz@pharma.novartis.com
Ritchie
T J
TJ
Hallett
A
A
Snell
C R
CR
Ko
S Y
SY
Wrigglesworth
R
R
Hughes
G A
GA
Dunstan
A R
AR
Bloomfield
G C
GC
Drake
G S
GS
Brown
M C
MC
Lee
W
W
Burgess
G M
GM
Davis
C
C
Yaqoob
M
M
Perkins
M N
MN
Campbell
E A
EA
Davis
A J
AJ
Rang
H P
HP
D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D065168:Bradykinin Receptor Antagonists; D002460:Cell Line; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy; D011392:Proline / Q000031:analogs & derivatives; D011869:Radioligand Assay; D051381:Rats; D043782:Receptor, Bradykinin B2; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D065168:Bradykinin Receptor Antagonists; C406222:N-(4-(2-(2-((2-dmethylaminoethyl)methylamino)ethylaminocarbonyl)pyrrolidinylsulfonyl)-2-nitrophenylamino)-N'-diphenylmethylthiourea; D043782:Receptor, Bradykinin B2; D011392:Proline; D013890:Thiourea