title: Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects.
abstract: OBJECTIVE
  To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects.
  
  
  METHODS
  Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography.
  
  
  RESULTS
  Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 +/- 0.04 microgram/ml (mean +/- SEM) and 1.34 +/- 0.14 micrograms/ml respectively (p < 0.0001).
  
  
  CONCLUSIONS
  Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Cekiç
authors.forename: C
authors.initials: C
authors.lastname: Batman
authors.forename: Y
authors.initials: Y
authors.lastname: Totan
authors.forename: U
authors.initials: U
authors.lastname: Yasar
authors.forename: N E
authors.initials: NE
authors.lastname: Basci
authors.forename: A
authors.initials: A
authors.lastname: Bozkurt
authors.forename: S O
authors.initials: SO
authors.lastname: Kayaalp
authors.forename: O
authors.initials: O
authors.lastname: Zilelioglu
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D019072:Antibiotic Prophylaxis / Q000379:methods; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions
chemical_list: D000890:Anti-Infective Agents; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D015242:Ofloxacin