Oxcarbazepine versus carbamazepine treatment and induction of serum lipid abnormalities.
Long-term treatment with carbamazepine is associated with many metabolic changes, including elevations in serum cholesterol, high-density lipoprotein, low-density lipoprotein, and triglyceride levels. Oxcarbazepine has been reported to be a preferable antiepileptic drug, when compared to carbamazepine with respect to its effects on lipid metabolism, especially cholesterol, high-density lipoproteins, and low-density lipoproteins. The case of a 16-year-old girl who developed high serum cholesterol and low-density lipoprotein levels on both of these medications successively, while triglyceride and high-density lipoprotein levels were unaffected, is reported.
Papacostas
S
S
Cyprus Institute of Neurology and Genetics, Nicosia.
D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002220:Carbamazepine / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002675:Child, Preschool; D008078:Cholesterol, LDL / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000139:chemically induced*; D008111:Liver Function Tests; D000078330:Oxcarbazepine; D012640:Seizures / Q000188:drug therapy; D014280:Triglycerides / Q000097:blood
D000927:Anticonvulsants; D008078:Cholesterol, LDL; D014280:Triglycerides; D002220:Carbamazepine; D000078330:Oxcarbazepine