Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci.
Nonobese diabetic (NOD) mice carrying a segment of chromosome flanking the disrupted IFN-gamma receptor gene from original 129 ES cells are resistant to development of diabetes. However, extended backcrossing of this mouse line to the NOD mouse resulted in a segregation of the IFN-gammaR-deficient genotype from the diabetes-resistant phenotype. These results indicate that the protection of NOD mice from the development of diabetes is not directly linked to the defective IFN-gamma receptor gene but, rather, is influenced by the presence of a diabetes-resistant gene(s) closely linked to the IFN-gammaR loci derived from the 129 mouse strain.
Kanagawa
O
O
Center for Immunology, Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110, USA. kanagawa@pathbox.wustl.edu
Xu
G
G
Tevaarwerk
A
A
Vaupel
B A
BA
D019264:Adoptive Transfer; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D008040:Genetic Linkage / Q000276:immunology*; D005819:Genetic Markers / Q000276:immunology; D020022:Genetic Predisposition to Disease / Q000209:etiology / Q000235:genetics*; D005838:Genotype; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis; D007113:Immunity, Innate / Q000235:genetics; D007371:Interferon-gamma / Q000378:metabolism / Q000494:pharmacology; D007515:Islets of Langerhans / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D017471:Receptors, Interferon / Q000096:biosynthesis / Q000235:genetics*; D000096743:Interferon gamma Receptor
D005819:Genetic Markers; D015395:Histocompatibility Antigens Class I; D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor