Genomic-scale analysis of gene expression in resting and activated T cells.
Recent advances in gene array technology and isolation of lymphocytes now allow comprehensive analysis of gene expression in many different types of T cells. So far only a few sets of results have been published. However it is already clear that these analyses provide accurate measurements of gene expression in T cells. This technology offers the first opportunity to examine global and subtle changes in gene expression in response to specific stimuli.
Marrack
P
P
Departments of Biochemistry and Molecular Biology, Immunology and Medicine, Howard Hughes Medical Institute, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, CO 80206, USA. marrackp@njc.org
Mitchell
T
T
Hildeman
D
D
Kedl
R
R
Teague
T K
TK
Bender
J
J
Rees
W
W
Schaefer
B C
BC
Kappler
J
J
D000818:Animals; D002469:Cell Separation; D016208:Databases, Factual; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D016678:Genome; D006358:Hot Temperature; D006801:Humans; D019169:Jurkat Cells; D008213:Lymphocyte Activation / Q000187:drug effects / Q000235:genetics*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D010703:Phorbol Esters / Q000494:pharmacology; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism
D010703:Phorbol Esters; D012333:RNA, Messenger