[Loss of junB expression causes a myeloproliferative syndrome resembling chronic myeloid leukemia].
JunB, a member of the AP-1 family of transcription factors, has been implicated in the control of proliferation and differentiation of various cell types including myeloid cells. We found that absence of junB expression in the myeloid lineage of mice lead to a myeloproliferative syndrome resembling human chronic myeloid leukaemia. The disease was due to a cell autonomous increase in the proliferation of immature myeloid cells. These results suggest that junB is a negative regulator of myelopoiesis.
Jochum
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Forschungsinstitut für Molekulare Pathologie (I.M.P.), Wien, Osterreich.
Passegue
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Wagner
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EF
D000818:Animals; D016758:Genes, jun; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009196:Myeloproliferative Disorders / Q000235:genetics*; D016755:Proto-Oncogene Proteins c-jun / Q000172:deficiency / Q000235:genetics / Q000502:physiology*
D016755:Proto-Oncogene Proteins c-jun