Magnesium oxide augmentation of verapamil maintenance therapy in mania.
The authors compared the antimanic effects of a verapamil-magnesium oxide (V-M) combination with a verapamil-placebo combination (V-P) in patients pretreated with verapamil. BPRS scores and serum magnesium levels were compared. The V-M combination was found to be significantly more effective than V-P in reducing manic symptoms (P=0.015). Serum magnesium levels were significantly higher in the V-M group (P<0.04). These data suggest that magnesium may increase antimanic efficacy of verapamil by mechanisms which may operate at the intracellular level. The magnesium-verapamil combination may have clinical application as an adjunct to verapamil in the maintenance therapy of mania.
Giannini
A J
AJ
Chemical Abuse Centers Inc., 721 Boardman-Poland Road, Suite 200, Boardman, OH 44512-5105, USA.
Nakoneczie
A M
AM
Melemis
S M
SM
Ventresco
J
J
Condon
M
M
D000328:Adult; D018692:Antimanic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D004032:Diet; D004359:Drug Therapy, Combination; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D008297:Male; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use*
D018692:Antimanic Agents; D014700:Verapamil; D008274:Magnesium