Evaluation of autoantibodies against oxidized LDL and antioxidant status in top soccer and basketball players after 4 months of competition.
Antioxidant status and titers of autoantibodies against oxidized low-density lipoproteins (ox-LDL-Ab) were investigated in top soccer (S; n = 21, age 24.6 +/- 4.3 years) and basketball (B; n 3,000 mIU/ml) in ox-LDL-Ab were found in half the players (12S and 4B) with a maximum reaching 6000 mIU/ml (normal range: 200-600 mIU/ml), showing an in vivo LDL oxidation. There was no correlation between ox-LDL-Ab titers and chlolesterol, LDL cholesterol, or antioxidant levels. Nevertheless, plasma vitamin C concentration was lower in athletes having high levels of ox-LDL-Ab when compared with those with normal levels (8.49 +/- 3.14 mirogram/ml vs. 10.39 +/- 2.55 microgram/ml), but this difference was not statistically significant. In conclusion, our data suggest that potential atherogenic and cardiovascular risks as reflected by high titers in ox-LDL-Ab may exist in some top athletes despite a nonaltered antioxidant status.
Pincemail
J
J
University of Liège CHU, Department of Cardiovascular Surgery and CREDEC, Liège, Belgium. J.pincemail.ulg.ac.be
Lecomte
J
J
Castiau
J
J
Collard
E
E
Vasankari
T
T
Cheramy-Bien
J
J
Limet
R
R
Defraigne
J
J
D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001490:Basketball / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance; D012643:Selenium / Q000097:blood; D012916:Soccer / Q000502:physiology*; D013997:Time Factors; D014801:Vitamin A / Q000097:blood; D014810:Vitamin E / Q000097:blood; D014815:Vitamins / Q000097:blood*
D000975:Antioxidants; D001323:Autoantibodies; D008077:Lipoproteins, LDL; D014815:Vitamins; C099252:oxidized low density lipoprotein; D014801:Vitamin A; D014810:Vitamin E; D002784:Cholesterol; D005979:Glutathione Peroxidase; D012643:Selenium; D001205:Ascorbic Acid