Endothelial apoptosis: could it have a role in the pathogenesis and treatment of disease?
Endothelial apoptosis can be found in a number of diseases. This review summarizes the current knowledge about the causes and consequences of endothelial apoptosis, and analyzes its possible role in the pathogenesis and treatment of several diseases. Novel forms of therapy based on the proposed pathophysiologic mechanisms are discussed.
Stefanec
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Section of Critical Care Medicine, Saint Vincent Hospital and Medical Center, New York, NY, USA. stefanet@mskcc.org
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology*