Relationships between cholesterol, apolipoprotein E polymorphism and dementia: a cross-sectional analysis from the PAQUID study.
This study assesses the cross-sectional relationship between serum cholesterol level and dementia, controlling for apolipoprotein E (apoE) genotype, in a nested case-control study of 334 elderly French subjects aged 73 and over who participated in the PAQUID study (37 demented subjects and 297 nondemented controls). A diagnosis of dementia was established by two-step screening: (1) psychometric testing and DSM-III-R criteria and (2) neurologist's confirmation. Cholesterol, its fractions and apoE genotype were determined from a blood sample. Elevated high-density lipoprotein cholesterol was associated with a significantly decreased risk of dementia, independent of apoE status and other potential confounding variables, suggesting that cholesterol fractions could be involved in both Alzheimer's disease and vascular dementia.
Bonarek
M
M
INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.
Barberger-Gateau
P
P
Letenneur
L
L
Deschamps
V
V
Iron
A
A
Dubroca
B
B
Dartigues
J F
JF
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001057:Apolipoproteins E / Q000032:analysis* / Q000235:genetics; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D003704:Dementia / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies
D001057:Apolipoproteins E; D008076:Cholesterol, HDL