The relationship of oxidized lipids to coronary artery stenosis.
A total of 1200 patients with angina were cardiac catheterized establishing that 63% had 70-100% stenosis, 12% had 10-69% stenosis of one or more of their coronary arteries and 25% had microvascular angina listed as 0% stenosis. Prior to catheterization 10 ml of blood was drawn and the plasma subjected to analysis for the concentration of cholesterol, lipid peroxides (LPX), total antioxidant capacity (TAOC), fibrinogen (FB), ceruloplasmin (CP) and activation of polymorphonuclear leukocytes (PMNLs). Comparisons were made to non-smoking controls without angina. Significant differences in LPX were found between the patients with 0 and 10-69% stenosis (P<0.001), with 10-69 and 70-100% stenosis (P<0.001), and with 0 and 70-100% stenosis (P<0.001). Under 70 years of age there was a significant difference in LPX between patients with all levels of stenosis and age and sex matched controls (P<0.001). Differences in the mean plasma cholesterol concentration for different levels in the degree of stenosis were not significant, indicating that LPX provided consistent data on the severity of stenosis while the plasma cholesterol concentration did not. Compared with controls an increase in activation of PMNLs (P<0.01), an increase in concentration of both FB and CP (P<0.01) and a decrease in total antioxidant capacity were noted in the plasma of catheterized patients. In summary the concentration of oxidation products rather than the concentration of cholesterol in the plasma identified stenosis in cardiac catheterized patients.
Kummerow
F A
FA
The Burnsides Research Laboratory and The Harlan E. Moore Heart Research Foundation, University of Illinois, 1208 W. Pennsylvania Avenue, Urbana, IL 61801, USA.
Olinescu
R M
RM
Fleischer
L
L
Handler
B
B
Shinkareva
S V
SV
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D006328:Cardiac Catheterization; D002570:Ceruloplasmin / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D015227:Lipid Peroxidation; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011336:Probability; D018570:Risk Assessment; D017678:Sex Distribution
D000975:Antioxidants; D015415:Biomarkers; D005340:Fibrinogen; D002784:Cholesterol; D002570:Ceruloplasmin