title: Current distribution of a pyrethroid resistance gene (kdr) in Anopheles gambiae complex from west Africa and further evidence for reproductive isolation of the Mopti form.
abstract: In the field, the kdr mutation, involved in pyrethroid resistance, has been found widely distributed in the Savanna form of Anopheles gambiae s.s., but never in wild populations of the Mopti form or An. arabiensis, even in areas where both occur in sympatry with resistant Savanna populations. Under laboratory conditions, Mopti and Savanna forms were fully able to interbreed and the kdr mutation was transmissible from one form to the other. Both forms appeared to be exposed to pyrethroid selection pressure in the field. The absence of the kdr mutation in the Mopti form and the total lack of Mopti-Savanna heterozygotes in field populations provides further evidence of a pre-copulatory barrier to gene flow between these two forms. Molecular markers, including kdr, are powerful tools for studying population genetics and circulation of resistance genes, and should be used through an integrated approach for a better understanding of the speciation process.
authors.affiliation: LIN/IRD, Montpellier, France.
authors.forename: F
authors.initials: F
authors.lastname: Chandre
authors.forename: S
authors.initials: S
authors.lastname: Manguin
authors.forename: C
authors.initials: C
authors.lastname: Brengues
authors.forename: J
authors.initials: J
authors.lastname: Dossou Yovo
authors.forename: F
authors.initials: F
authors.lastname: Darriet
authors.forename: A
authors.initials: A
authors.lastname: Diabate
authors.forename: P
authors.initials: P
authors.lastname: Carnevale
authors.forename: P
authors.initials: P
authors.lastname: Guillet
mesh_terms: D000354:Africa, Western; D000818:Animals; D000852:Anopheles / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D011722:Pyrethrins / Q000494:pharmacology*; D012098:Reproduction
chemical_list: D011722:Pyrethrins