title: Dual function glutamate-related ligands: discovery of a novel, potent inhibitor of glutamate carboxypeptidase II possessing mGluR3 agonist activity.
authors.affiliation: Drug Discovery Program, Georgetown Institute for Cognitive & Computational Sciences, Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, N.W., Washington, D.C. 20007-2197, USA.
authors.forename: F
authors.initials: F
authors.lastname: Nan
authors.forename: T
authors.initials: T
authors.lastname: Bzdega
authors.forename: S
authors.initials: S
authors.lastname: Pshenichkin
authors.forename: J T
authors.initials: JT
authors.lastname: Wroblewski
authors.forename: B
authors.initials: B
authors.lastname: Wroblewska
authors.forename: J H
authors.initials: JH
authors.lastname: Neale
authors.forename: A P
authors.initials: AP
authors.lastname: Kozikowski
mesh_terms: D000818:Animals; D016466:CHO Cells; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors*; D002460:Cell Line; D006224:Cricetinae; D004151:Dipeptides / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043425:Glutamate Carboxypeptidase II; D005977:Glutarates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D010721:Phosphinic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D004151:Dipeptides; D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; D005977:Glutarates; D008024:Ligands; D010721:Phosphinic Acids; D018094:Receptors, Metabotropic Glutamate; C406223:bis(glutar-2-ylmethyl)phosphinic acid; C102718:metabotropic glutamate receptor 3; C027172:isospaglumic acid; D002268:Carboxypeptidases; D043425:Glutamate Carboxypeptidase II