[The role of biochemical processes in the pathogenesis of complicated hydrocephalus in children].
Spinal fluid radical formation levels, malonic dialdehyde concentrations, and intrinsic antioxidative activity were studied in 84 patients with hydrocephalus. The findings suggest that there is a considerable activation of free radical reactions and lipid peroxidation, as well as a reduction in antioxidative activity. These changes were most drastically profound in children with inflammation-complicated hydrocephalus with spinal fluid hemorrhagic changes in particular. Timely correction of impaired energy exchange in children by using antioxidants and nootropics promotes the arrest of inflammation and prevents a number of postoperative complications.
Mirsadykov
D A
DA
Artarian
A A
AA
Promyslov
M Sh
MSh
Aref'eva
I A
IA
D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000209:etiology; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000378:metabolism; D004359:Drug Therapy, Combination; D005609:Free Radicals / Q000134:cerebrospinal fluid; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D007223:Infant; D015227:Lipid Peroxidation; D008163:Luminescent Measurements; D008315:Malondialdehyde / Q000134:cerebrospinal fluid; D018697:Nootropic Agents / Q000627:therapeutic use
D000975:Antioxidants; D005609:Free Radicals; D018697:Nootropic Agents; D008315:Malondialdehyde