title: Simultaneous determination of tinidazole, furazolidone and diloxanide furoate in a combined tablet preparation by second-derivative spectrophotometry.
abstract: A second-derivative spectrophotometric procedure has been developed for the simultaneous determination of tinidazole (TD), furazolidone (FD) and diloxanide furoate (DF) in a commercial preparation. The method consists of the utilization of second-derivative absorption spectra of tablet extract in distilled water and then determination of the analyte concentration in the mixture was carried out using zero-crossing (ZC) and ratio-compensation (RC) techniques. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of TD (5-20 microg ml(-1)), FD (2.5-10 microg ml(-1)) and DF (7.5-15 microg ml(-1)). The results were found to be accurate and free from interference. The details of the statistical treatment of analytical data are also presented.
authors.affiliation: Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India. cvnp@bits-pilani.ac.in
authors.forename: C V
authors.initials: CV
authors.lastname: Prasad
authors.forename: V
authors.initials: V
authors.lastname: Sripriya
authors.forename: R N
authors.initials: RN
authors.lastname: Saha
authors.forename: P
authors.initials: P
authors.lastname: Parimoo
mesh_terms: D000981:Antiprotozoal Agents / Q000032:analysis*; D004338:Drug Combinations; D005663:Furans / Q000032:analysis; D005664:Furazolidone / Q000032:analysis; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D013607:Tablets / Q000032:analysis; D014011:Tinidazole / Q000032:analysis
chemical_list: D000981:Antiprotozoal Agents; D004338:Drug Combinations; D005663:Furans; D013607:Tablets; D014011:Tinidazole; D005664:Furazolidone; C004932:diloxanide furoate