title: Automated exchange transfusion for life-threatening plasmodium falciparum malaria--lessons relating to prophylaxis and treatment.
abstract: We report a case of traveller to Kenya who contracted severe plasmodium falciparum malaria complicated by disseminated intravascular coagulation and acute renal failure. She had taken no antimalarial prophylaxis in view of concerns in the media regarding the adverse effects of mefloquine. There was a protracted delay before the diagnosis of malaria was made. Clinical recovery occurred following treatment with intravenous quinine, haemofiltration and manual/automated red-cell exchange transfusions. Automated red-cell exchange transfusion resulted in a marked decrease in the parasitaemia, before a response to quinine therapy would have been anticipated, leading to a successful outcome thereafter. In conjunction with other groups we therefore feel that exchange transfusions should be considered in seriously ill patients with falciparum malaria, multiorgan complications and parasitaemias greater than 10%.
authors.affiliation: Department of Haematology, Royal Hallamshire Hospital NHS Trust, Sheffield, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Mainwaring
authors.forename: M J
authors.initials: MJ
authors.lastname: Leach
authors.forename: N
authors.initials: N
authors.lastname: Nayak
authors.forename: S T
authors.initials: ST
authors.lastname: Green
authors.forename: D A
authors.initials: DA
authors.lastname: Jones
authors.forename: D A
authors.initials: DA
authors.lastname: Winfield
mesh_terms: D000328:Adult; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000517:prevention & control / Q000628:therapy*; D015767:Mefloquine / Q000627:therapeutic use; D018512:Parasitemia / Q000628:therapy; D014195:Travel
chemical_list: D015767:Mefloquine