Neurofilaments run sprints not marathons.
In neurons, cytoskeletal proteins are transported from where they are made - the cell body - along the axons, but it has long been disputed whether they are transported as subunits or polymers. A new analysis of neurofilament movement may help to resolve the controversy.
Brady
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D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001692:Biological Transport; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000378:metabolism*; D018076:DNA, Complementary / Q000008:administration & dosage; D049452:Green Fluorescent Proteins; D006801:Humans; D008164:Luminescent Proteins / Q000235:genetics; D008954:Models, Biological; D016501:Neurites / Q000378:metabolism; D016900:Neurofilament Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
D018076:DNA, Complementary; D008164:Luminescent Proteins; D016900:Neurofilament Proteins; D011993:Recombinant Fusion Proteins; C061195:neurofilament protein M; D049452:Green Fluorescent Proteins