title: The effect of locally delivered controlled-release doxycycline or scaling and root planing on periodontal maintenance patients over 9 months.
abstract: BACKGROUND
  This research report evaluates clinical changes resulting from local delivery of doxycycline hyclate (DH) or traditional scaling and root planing (SRP) in a group of patients undergoing supportive periodontal therapy (SPT).
  
  
  METHODS
  In all, 141 patients received either DH (67) or SRP (74) treatment in sites > or =5 mm on one-half of their dentition at baseline and month 4.
  
  
  RESULTS
  Clinical results were determined at month 9. Baseline mean probing depth recordings were similar between the two groups (DH = 5.9 mm; SRP = 5.9 mm). Mean month 9 results showed similar clinical results for attachment level gain (DH 0.7 mm; SRP 0.8 mm) and probing depth reduction (DH 1.3 mm; SRP 1.1 mm). Percentage of sites showing > or =2 mm attachment level gain at month 9 was 24.7% in the DH group and 21.2% in the SRP group. Thirty-nine percent (39%) of DH sites and 38% of SRP sites showed > or =2 mm probing depth reduction. When treated sides of the dentition were compared to untreated sides, DH showed a difference in disease activity (> or =2 mm attachment loss) from 19.3% (untreated) to 7.2% (treated); and SRP from 14.3% (untreated) to 8.1% (treated).
  
  
  CONCLUSIONS
  Results show that both DH without concomitant mechanical instrumentation and SRP were equally effective as SPT in this patient group over the 9-month study period.
authors.affiliation: Atrix Laboratories, Inc, Fort Collins, CO 80525-4417, USA.
authors.forename: S
authors.initials: S
authors.lastname: Garrett
authors.forename: D F
authors.initials: DF
authors.lastname: Adams
authors.forename: G
authors.initials: G
authors.lastname: Bogle
authors.forename: K
authors.initials: K
authors.lastname: Donly
authors.forename: C H
authors.initials: CH
authors.lastname: Drisko
authors.forename: W W
authors.initials: WW
authors.lastname: Hallmon
authors.forename: E B
authors.initials: EB
authors.lastname: Hancock
authors.forename: P
authors.initials: P
authors.lastname: Hanes
authors.forename: C E
authors.initials: CE
authors.lastname: Hawley
authors.forename: L
authors.initials: L
authors.lastname: Johnson
authors.forename: R
authors.initials: R
authors.lastname: Kiger
authors.forename: W
authors.initials: W
authors.lastname: Killoy
authors.forename: J T
authors.initials: JT
authors.lastname: Mellonig
authors.forename: F J
authors.initials: FJ
authors.lastname: Raab
authors.forename: M
authors.initials: M
authors.lastname: Ryder
authors.forename: N
authors.initials: N
authors.lastname: Stoller
authors.forename: A
authors.initials: A
authors.lastname: Polson
authors.forename: H L
authors.initials: HL
authors.lastname: Wang
authors.forename: L E
authors.initials: LE
authors.lastname: Wolinsky
authors.forename: R A
authors.initials: RA
authors.lastname: Yukna
authors.forename: C Q
authors.initials: CQ
authors.lastname: Harrold
authors.forename: M
authors.initials: M
authors.lastname: Hill
authors.forename: V B
authors.initials: VB
authors.lastname: Johnson
authors.forename: G L
authors.initials: GL
authors.lastname: Soouthard
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D012534:Dental Scaling; D004318:Doxycycline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000517:prevention & control; D010510:Periodontal Diseases / Q000517:prevention & control*; D010514:Periodontal Pocket / Q000517:prevention & control; D012008:Recurrence; D016745:Root Planing; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D004318:Doxycycline