title: Remission onset and relapse in depression. An 18-month prospective study of course for 100 first admission patients.
abstract: BACKGROUND
  Few prospective studies of course for first admission depressives are reported.
  
  
  METHODS
  One hundred consecutive depressed inpatients were followed prospectively over 18 months. Course was defined operationally using the Hamilton Depression scale and ICD-10 criteria. Results were analysed using life-tables.
  
  
  RESULTS
  The cumulative probabilities of remission onset by 3 and 18 months were 0.67 (95% C.I.=0.57-0.77) and 0.82 (95% C.I.=0.74-0.90). The cumulative probability of relapse was 0.25 (95% C.I.=0.15-0.35); 53% of those relapsing did so in the first 2 months. Younger age at onset, longer illness length, higher depression and anxiety ratings, predicted delayed remission onset. ICD-10 episode severity predicted relapse.
  
  
  CONCLUSIONS
  The chances of remission onset at 3 months and relapse were increased relative to other studies; risk of chronicity was similar. Predictors of outcome to emerge were similar to other studies.
  
  
  CONCLUSIONS
  Adoption of these remission onset criteria may identify earlier (at 3 months), subjects at high risk of chronicity. After remission onset, subjects with severe illnesses warrant careful follow-up to detect relapse, particularly during the first 2 months.
  
  
  CONCLUSIONS
  The operational criteria used were different to other prospective studies. Relatively few psychosocial variables were included in the analysis.
authors.affiliation: Department of Psychiatry, University of Dublin, Trinity College, Dublin, Ireland.
authors.forename: D
authors.initials: D
authors.lastname: O'Leary
authors.forename: F
authors.initials: F
authors.lastname: Costello
authors.forename: N
authors.initials: N
authors.lastname: Gormley
authors.forename: M
authors.initials: M
authors.lastname: Webb
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000534:rehabilitation*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D012016:Reference Values; D012074:Remission Induction; D012720:Severity of Illness Index; D013997:Time Factors