title: Sleep disorders and portal-systemic encephalopathy following transjugular intrahepatic portosystemic stent shunt in patients with liver cirrhosis. Relation to plasma tryptophan.
abstract: Neuropsychiatric symptoms due to any type of dysfunction and/or portal-systemic shunting are summarized as hepatic encephalopathy (HE). HE in the presence of liver cirrhosis and/or portal-systemic shunting has been termed portal-systemic encephalopathy (PSE). PSE is most frequent among the HE syndromes and is almost exclusively seen in patients with advanced cirrhosis and portal hypertension. Portal-systemic shunting either spontaneous due to portal hypertension, following surgical portocaval anastomosis, or subsequent to transjugular intrahepatic portosystemic stent-shunt (TIPSS) is regarded as the primary causative condition for PSE, not hepatic dysfunction per se. PSE may be considered as a disorder of multiple neurotransmitter systems among which derangements of the serotonergic system have been documented most consistently. Incipient PSE is frequently paralleled by the occurrence of sleep disorders, however, their relation to PSE remains unclear. We observed a transient increase of sleep disorders post-TIPSS, which were only in part correlated to other symptoms of PSE. Among the biochemical parameters studied only an association between arterial ammonia levels and sleep disorders became apparent, whereas no significant relation was observed for peripheral tryptophan.
authors.affiliation: Dept. of Psychiatry, University of Göttingen, Germany. jwiltfa@gwdg.de
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
authors.forename: W
authors.initials: W
authors.lastname: Nolte
authors.forename: J
authors.initials: J
authors.lastname: von Heppe
authors.forename: E
authors.initials: E
authors.lastname: Bahn
authors.forename: J
authors.initials: J
authors.lastname: Pilz
authors.forename: G
authors.initials: G
authors.lastname: Hajak
authors.forename: E
authors.initials: E
authors.lastname: Rüther
authors.forename: G
authors.initials: G
authors.lastname: Ramadori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000641:Ammonia / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006501:Hepatic Encephalopathy / Q000209:etiology*; D006801:Humans; D006975:Hypertension, Portal / Q000601:surgery*; D008103:Liver Cirrhosis / Q000097:blood* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic / Q000009:adverse effects*; D012893:Sleep Wake Disorders / Q000209:etiology*; D015607:Stents / Q000009:adverse effects*; D013997:Time Factors; D014364:Tryptophan / Q000097:blood*
chemical_list: D000641:Ammonia; D014364:Tryptophan