Antinociceptive activity of I3,II8-binaringenin, a biflavonoid present in plants of the guttiferae.
This paper describes the antinociceptive action of 13,118-binaringenin (GB-1a), a biflavonoid isolated from Clusia columnaris and present in several plants of the family Guttiferae, in a writhing test and a formalin test. It was found that it exhibits potent and dose-related antinociceptive action in both experimental models, with ID50 values of 22 mumol/kg against the writhing test and 28 mumol/kg against the second phase of the formalin test. It was more potent than some well-known analgesic drugs used as reference. Based on a hot-plate test its mechanism of action seems to be unrelated with the opioid receptors.
Bittar
M
M
de Souza
M M
MM
Yunes
R A
RA
Lento
R
R
Delle Monache
F
F
Cechinel Filho
V
V
D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D044946:Biflavonoids; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010944:Plants / Q000737:chemistry*
D018712:Analgesics, Non-Narcotic; D044946:Biflavonoids; D005419:Flavonoids; C406718:I3,II8-binaringenin