Recombinant in vitro tools to predict drug metabolism and safety.
Drug metabolism determines several pharmacological and toxicological properties of pharmaceuticals and is catalysed by drug metabolizing enzymes. Prediction of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes. This review describes and evaluates the use of recombinant models that contain human drug metabolizing enzymes to facilitate the prediction of pharmacokinetic properties of candidate drugs in humans.
Friedberg
I
Biomedical Research Centre,Ninewells Hospital and Medical School, Ninewells Hospital, Dundee, UK DD1 9SY.