[Biology of brain metastases: current concepts].
Brain metastasis results from complex interactions between host cells and primitive tumor cells. An analysis of the molecular pathways at the cellular level is provided in this review of the literature. The principal new therapeutic modalities are directly based on our comprehension of those molecular biology hypothesis.
Kehrli
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Service de Neurochirurgie, Hôpital de Hautepierre, avenue Molière, 67098 Strasbourg Cedex, France.
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism / Q000556:secondary*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology; D018450:Disease Progression; D010450:Endopeptidases / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008833:Microcirculation; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating; D009389:Neovascularization, Pathologic; D009414:Nerve Growth Factors / Q000502:physiology; D009928:Organ Specificity
D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; D010450:Endopeptidases