[Insulin resistance induced by drugs or agents].
Glucocorticoids, oral contraceptives and nicotinic acid are associated with glucose intolerance, and the main cause of the glucose intolerance induced by these drugs is insulin resistance. Particularly glucocorticoids are difficult to substitute for another drugs, and frequency cause glucose intolerance. Now thiazolidinediones is available for reducing insulin resistance in clinical. And there are several evidences that thiazolidinediones can reduce insulin resistance induced by glucocorticoids in rats. But the clinical evidences are little. In future, it is necessary to investigate whether thiazolidinediones would be effective on reducing glucocorticoid-induced insulin resistance in clinical.
Matsui
J
J
Third Department of Internal Medicine, Hirosaki University School of Medicine.
Nakamura
J
J
Ogawa
Y
Y
Nakamura
T
T
Suda
T
T
D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects; D001581:Benzothiadiazines; D002839:Chromans / Q000494:pharmacology / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000009:adverse effects; D004232:Diuretics; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007333:Insulin Resistance; D009525:Niacin / Q000009:adverse effects; D051381:Rats; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use; D045162:Thiazolidinediones; D000077288:Troglitazone
D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D002839:Chromans; D003276:Contraceptives, Oral; D004232:Diuretics; D005938:Glucocorticoids; D007004:Hypoglycemic Agents; D049993:Sodium Chloride Symporter Inhibitors; D013844:Thiazoles; D045162:Thiazolidinediones; D009525:Niacin; D000077288:Troglitazone