Determination of tungsten in bulk drug substance and intermediates by ICP-AES and ICP-MS.
A quick and sensitive method has been developed and validated for the determination of tungsten in bulk drug substance and intermediates using either Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Sample preparation is by direct dissolution with a 80:20 (v/v) concentrated nitric acid:deionized water mixture and avoids labor intensive and potentially hazardous digestion techniques. Excellent agreement was found between ICP-AES and ICP-MS results and between Merck results and Microwave Induced Plasma Mass Spectrometry (MIP-MS) results provided by an independent raw material vendor.
Wang
T
T
Analytical Research Department, Merck Research Laboratories, Rahway, NJ 07065-0900, USA.
Ge
Z
Z
Wu
J
J
Li
B
B
Liang
A
A
D013058:Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011786:Quality Control; D012015:Reference Standards; D015203:Reproducibility of Results; D013052:Spectrometry, X-Ray Emission / Q000379:methods*; D014414:Tungsten / Q000032:analysis*
D004364:Pharmaceutical Preparations; D014414:Tungsten