title: Successful allogeneic bone marrow transplantation for childhood-onset refractory anemia with ringed sideroblasts.
abstract: Refractory anemia with ringed sideroblasts (RARS) is an extremely rare type of myelodysplastic syndrome in children. We describe a 10-year-old boy with RARS presented with pancytopenia. He remained relatively stable with only a few transfusions until age of 20 years, when he underwent an allogeneic bone marrow transplantation (BMT) because of increased transfusion requirements. He remains in complete chimeric state at 20 months posttransplant with normal hematologic parameters. To our knowledge, this is the first description of successful BMT in a patient with childhood-onset RARS. The indication of BMT for this rare disorder in children is discussed.
authors.affiliation: Department of Pediatrics, Hematopoietic Stem Cell Transplant Program, Chonnam National University Medical School, Kwangju, Korea. hoonkook@chonnam.ac.kr
authors.forename: H
authors.initials: H
authors.lastname: Kook
authors.forename: C J
authors.initials: CJ
authors.lastname: Kim
authors.forename: W S
authors.initials: WS
authors.lastname: Yoon
authors.forename: D W
authors.initials: DW
authors.lastname: Ryang
authors.forename: T J
authors.initials: TJ
authors.lastname: Hwang
mesh_terms: D000753:Anemia, Refractory / Q000628:therapy*; D000756:Anemia, Sideroblastic / Q000628:therapy*; D016026:Bone Marrow Transplantation; D002648:Child; D006801:Humans; D008297:Male; D014184:Transplantation, Homologous