title: The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization.
abstract: Herein we report the cloning of cDNAs and incompletely processed hnRNAs from endothelia and heart that encode the alpha10 subunit forming part of the novel collagen type II-binding integrin alpha10beta1 of chondrocytes. Analysis of hnRNA clones and reported expressed sequence tags revealed the positions of 17 putative intron-exon splice junctions shared with those of the p150,95 (ITGAX) gene. Human alpha10 transcripts of 5.4 and 1.8 kb were not restricted to chondrocytes but, instead, were widely expressed in a panel of 24 tissue types, where the highest expression was found in muscle and heart. The human alpha10 subunit gene (ITGA10) was localized to band q21 of chromosome 1.
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine and Health Science, The University of Auckland, Auckland, New Zealand.
authors.forename: K
authors.initials: K
authors.lastname: Lehnert
authors.forename: J
authors.initials: J
authors.lastname: Ni
authors.forename: E
authors.initials: E
authors.lastname: Leung
authors.forename: S
authors.initials: S
authors.lastname: Gough
authors.forename: C M
authors.initials: CM
authors.lastname: Morris
authors.forename: D
authors.initials: D
authors.lastname: Liu
authors.forename: S X
authors.initials: SX
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Langley
authors.forename: G W
authors.initials: GW
authors.lastname: Krissansen
mesh_terms: D000595:Amino Acid Sequence; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D003001:Cloning, Molecular; D017124:Conserved Sequence / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D004730:Endothelium, Vascular / Q000378:metabolism; D005091:Exons / Q000235:genetics*; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D015723:Gene Library; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D039001:Integrin alpha Chains; D016023:Integrins / Q000737:chemistry / Q000235:genetics*; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D009206:Myocardium / Q000378:metabolism; D020161:Physical Chromosome Mapping; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D018076:DNA, Complementary; D039001:Integrin alpha Chains; D016023:Integrins; D012333:RNA, Messenger; C406210:integrin alpha 10