Flow-injection extraction-spectrophotometric method for the determination of chlorhexidine in pharmaceutical preparations.
The spectrophotometric determination of trace amounts of chlorhexidine was carried out by liquid-liquid extraction using bromophenol blue with a flow system. The determination of chlorhexidine in the range of 1 x 10(-4) to 1 x 10(-5) M was possible with a sampling frequency of 40 samples per hour. The method was satisfactorily applied to the determination of chlorhexidine in pharmaceutical preparations.
Pérez-Ruiz
T
T
Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, Spain. tpr@fcu.um.es
Martínez-Lozano
C
C
Sanz
A
A
Sánchez
A
A
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D001978:Bromphenol Blue; D002710:Chlorhexidine / Q000032:analysis*; D017022:Flow Injection Analysis; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D015203:Reproducibility of Results; D012997:Solvents; D013053:Spectrophotometry / Q000379:methods
D000891:Anti-Infective Agents, Local; D004364:Pharmaceutical Preparations; D012997:Solvents; D001978:Bromphenol Blue; D002710:Chlorhexidine