title: Angiogenesis in early-invasive and low-malignant-potential epithelial ovarian carcinoma.
abstract: OBJECTIVE
  To evaluate angiogenesis in ovaries of women with stage I invasive and low-malignant-potential epithelial ovarian carcinoma.
  
  
  METHODS
  Ovarian specimens of 49 consecutive women with primary stage I invasive (n = 15) or stage I low-malignant-potential epithelial ovarian carcinoma (n = 34) were stained immunohistochemically for factor VIII-related antigen. Microvessel counts were tested for correlation with patient age, race, parity, previous oral contraceptive use, histologic type, tumor grade, tumor size, ascites, tumor excrescences, and disease-free and overall survival. Statistical analysis included multiple linear regression, Student t tests, factorial analysis of variance, and Cox proportional hazards regression, with P <.05 considered statistically significant.
  
  
  RESULTS
  Microvessel counts of ovarian specimens of women with stage I invasive epithelial ovarian carcinoma (median 30, range 17-73) were significantly higher than those of women with stage I low-malignant-potential epithelial ovarian carcinoma (median 10, range 5-23), (P <.001). Among women with low-malignant-potential disease, microvessel counts did not differ significantly between serous and mucinous carcinomas (median 10, range 5-23 versus median 11, range 5-20, respectively, P =.78). There was no correlation between microvessel counts and age, tumor grade, tumor size, ascites, or tumor excrescences.
  
  
  CONCLUSIONS
  Angiogenesis as assessed by microvessel counts is more intense in stage I invasive ovarian epithelial carcinoma compared with stage I low-malignant-potential carcinoma, and might assist in differentiating between these histopathologic entities.
authors.affiliation: Department of Obstetrics and Gynecology, State University of New York Health Science Center at Brooklyn, Brooklyn, NY 11203-2098, USA.
authors.forename: O
authors.initials: O
authors.lastname: Abulafia
authors.forename: J E
authors.initials: JE
authors.lastname: Ruiz
authors.forename: K
authors.initials: K
authors.lastname: Holcomb
authors.forename: T M
authors.initials: TM
authors.lastname: Dimaio
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: D M
authors.initials: DM
authors.lastname: Sherer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000098:blood supply* / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000473:pathology*