Microglia and neuritic plaques in familial Alzheimer's disease induced by a new mutation of presenilin-1 gene. An ultrastructural study.
The results of the ultrastructural study of the brains of two sisters with familial Alzheimer's disease (AD) induced by a new mutation of presenilin-1 (PS-1) gene who died at the young age (35 and 37 years) are presented. In both cases, the changes typical of AD with particularly large number of neuritic plaques (NPs) were found. Microglial cells were located between amyloid core and neurites. At the ultrastructural level, the content of microglial cytoplasm was differentiated (amyloid fibrils or/and phagocytic bodies). This may suggest that microglial cells participate in forming of amyloid fibrils and/or phagocytosis of amyloid.
Lewandowska
E
E
Department of Neuropathology, Institute of Psychiatry and Neurology, Warszawa.
Bertrand
E
E
Kulczycki
J
J
Lipczyńska-Lojkowska
W
W
Lechowicz
W
W
Stankiewicz
J
J
D000328:Adult; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D017628:Microglia / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000648:ultrastructure*; D017354:Point Mutation / Q000235:genetics; D053764:Presenilin-1
D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1