Increased bone turnover in epileptic patients treated with carbamazepine.
Bone turnover has been investigated in 12 epileptic patients before and after treatment with carbamazepine and in 15 sex- and age-matched control subjects. We found higher values of markers of bone formation (serum bone alkaline phosphatase, osteocalcin, and propeptides of types I and III procollagen) and of bone resorption (serum telopeptide of type I collagen and urine N-telopeptides of type I collagen) in patients than in controls. Our study demonstrates that carbamazepine induces an increase of bone turnover.
Verrotti
A
A
Department of Medicine, University of Chieti, Italy.
Greco
R
R
Morgese
G
G
Chiarelli
F
F
D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004828:Epilepsies, Partial / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008297:Male; D011446:Prospective Studies
D002220:Carbamazepine