title: Determination of the prevalence of fibrinogen Banks peninsula mutation (gamma280Tyr-->Cys) by PCR.
abstract: A mutation of Tyr-->Cys at position 280 of the gamma chain of fibrinogen was recently determined to be the cause for fibrinogen Banks peninsula. A novel polymerase chain reaction/restriction digestion assay for this mutation was developed and used for the screening of 300 apparently healthy European blood donors. None of these subjects carried the mutation.
authors.affiliation: Baxter Hyland Immuno, Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Zimmermann
authors.forename: P L
authors.initials: PL
authors.lastname: Turecek
authors.forename: H P
authors.initials: HP
authors.lastname: Schwarz
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D001317:Austria / Q000453:epidemiology; D015331:Cohort Studies; D017931:DNA Primers; D005060:Europe / Q000208:ethnology; D015241:Fibrinogens, Abnormal / Q000235:genetics*; D014644:Genetic Variation; D006579:Heterozygote; D006801:Humans; D008403:Mass Screening; D017354:Point Mutation; D016133:Polymerase Chain Reaction / Q000379:methods*; D012150:Polymorphism, Restriction Fragment Length; D015995:Prevalence; D015203:Reproducibility of Results; D044465:White People / Q000235:genetics
chemical_list: D017931:DNA Primers; D015241:Fibrinogens, Abnormal; C408369:fibrinogen Banks peninsula