[Specific changes in the parameters of blood antioxidant status in patients with cervical carcinoma in the course of cancer therapyĭ].
Parameters of the blood and plasma antioxidant systems were investigated at different stages of specific therapy for T3NxM0 cervical tumors in 23 patients to identify mechanisms of "relative" drug resistance. Treatment included preoperative telegammatherapy (10 Gy), aregional and regional lymphinfusion with low and high doses of cytostatics, respectively, complemented with endolymphatic injection of tocopherol acetate 100 ng. As a result, surgery after Wertheim became feasible in 14 out of 23 patients following external exposure to 30-40 Gy. Morphological examination detected metastases into the regional lymph nodes in 3 patients. The advantages offered by the treatment modality include adequate response to therapy as well as access to control of free-radical processes taking place in membranes of immunocompetent cells which in turn assures good clinical results.
Rozenko
L Ia
LIa
Research Institute of Oncology, Ministry of Health of the RF, Rostov-on-Don.
Sidorenko
Iu S
IuS
Frantsiiants
E M
EM
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D001790:Blood Physiological Phenomena; D002277:Carcinoma / Q000276:immunology* / Q000628:therapy*; D002374:Catalase / Q000378:metabolism; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007267:Injections; D008208:Lymphatic System; D008214:Lymphocytes / Q000276:immunology*; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000628:therapy*; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D005609:Free Radicals; D014801:Vitamin A; D014810:Vitamin E; D002374:Catalase; D013482:Superoxide Dismutase