Morphology and classification of acute myeloid leukemias.
The morphology and classification of AML are discussed. In addition to routine morphology and cytochemistry, however, it is now necessary to use newer modalities of immunocytochemistry or flow cytometry to confirm a diagnosis. These latter are essential for the diagnosis of the newer described entities of AML with minimal differentiation (FAB-M0) and acute megakaryoblastic leukemia (FAB-M7). Cytogenetics and fluorescent-in-situ-hybridization techniques are also very important for diagnosis as in FAB-M3 (promyelocytic leukemia) but also for detecting those myeloid leukemias that are associated with a favorable or unfavorable response.
Krause
J R
JR
Department of Pathology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000145:classification* / Q000473:pathology*