Successful non-surgical treatment of Candida tropicalis endocarditis with liposomal amphotericin-B (AmBisome).
Fungal endocarditis in children is most commonly a complication of palliative or curative surgery for congenital heart disease, rheumatic valvulitis and prolonged indwelling central venous and umbilical catheters. We describe here the case of a 3-y-old patient with chronic diarrhoea and prolonged total parenteral alimentation who developed severe C. tropicalis endocarditis and was treated successfully using a liposomal preparation of amphotericin-B (AmBisome) without surgical intervention.
Melamed
R
R
Pediatric Infectious Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Leibovitz
E
E
Abramson
O
O
Levitas
A
A
Zucker
N
N
Gorodisher
R
R
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy*; D002675:Child, Preschool; D002908:Chronic Disease; D003967:Diarrhea / Q000150:complications; D004337:Drug Carriers; D004452:Echocardiography; D004696:Endocarditis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D008081:Liposomes; D008297:Male; D016896:Treatment Outcome
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B