Lipid A and related compounds. XXXVII. Determination of favorable binding linkages of lipid A analog to antigen moiety for synthetic vaccines.
For the determination of favorable binding linkages of lipid A analog as a synthetic immunoadjuvant to the antigen moiety for synthetic vaccines, new N-acylated L-serine-containing D-glucosamine analogs (Type A, B, C) were synthesized and their mitogenicities were examined. Among chemically synthesized compounds (6-15, 30), compound 8 for Type B exhibited the most potent mitogenicity.
Ikeda
K
K
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Miyajima
K
K
Shimizu
T
T
Achiwa
K
K
D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry*; D008050:Lipid A / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000737:chemistry; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D014614:Vaccines, Synthetic / Q000737:chemistry* / Q000378:metabolism
D000942:Antigens, Bacterial; D008050:Lipid A; D008070:Lipopolysaccharides; D014614:Vaccines, Synthetic; D013936:Thymidine