Warfarin use and fracture risk.
Two recent studies examined the association between chronic use of warfarin, a vitamin K antagonist, and fracture rate among older women. Whereas one study reported no association, the other reported a significantly higher risk for vertebral and rib fractures among warfarin users compared with nonusers. The effect of vitamin K antagonists on age-related bone loss continues to be controversial.
Booth
S L
SL
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Mayer
J
J
D000818:Animals; D000925:Anticoagulants / Q000009:adverse effects*; D005260:Female; D050723:Fractures, Bone / Q000209:etiology*; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000209:etiology*; D014812:Vitamin K / Q000037:antagonists & inhibitors*; D014859:Warfarin / Q000009:adverse effects*; D016387:Women's Health
D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin