title: Capturing the paradigm shift in HIV treatment: changing attitudes in the choice of combination antiretroviral drugs by high HIV caseload Australian GPs (1996-1997).
abstract: The use of combination antiretroviral therapy for HIV infection is a rapidly changing field. To assess the impact of recent studies on prescribing patterns, two surveys of 21 high HIV caseload Australian GPs were undertaken in June 1996 and June 1997 to plot changes in the choice of combination antiviral therapy. Of the 17 GPs who responded to the survey in each year, the number of HIV-infected patients seen at their practices were estimated to be 5,061 in 1996 and 5,912 in 1997. In 1996, 40% of their patients were estimated to be on antiretroviral therapy compared to 60% in 1997 (p < 0.05). In 1996, most GPs preferred using dual combination therapy (59%); whereas in 1997, triple combination therapy was preferred (82%). Between 1996 and 1997, there was a significant change by high caseload Australian GPs in the choice of antiretroviral drugs with many combinations being preferred prior to presentation of efficacy data for those combinations, or recommendation through national guidelines.
authors.affiliation: Community HIV Research Network, University of New South Wales, Darlinghurst, Australia. don.smith@unsw.edu.av
authors.forename: D
authors.initials: D
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Goggin
authors.forename: H
authors.initials: H
authors.lastname: Meldrum
authors.forename: S
authors.initials: S
authors.lastname: Phillips
authors.forename: D
authors.initials: D
authors.lastname: Russell
authors.forename: M
authors.initials: M
authors.lastname: Bloch
authors.forename: N J
authors.initials: NJ
authors.lastname: Bodsworth
authors.forename: N
authors.initials: N
authors.lastname: Roth
authors.forename: M G
authors.initials: MG
authors.lastname: Law
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D001315:Australia / Q000453:epidemiology; D004359:Drug Therapy, Combination; D005194:Family Practice / Q000706:statistics & numerical data* / Q000639:trends*; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data* / Q000639:trends*
chemical_list: D019380:Anti-HIV Agents