title: Can magnesium sulfate reduce the risk of cerebral injury after perinatal asphyxia?
abstract: Hypoxia-ischemia produces brain damage by processes that continue for many hours after reoxygenation/reperfusion. This provides a window of opportunity for therapy aimed at preventing further loss of brain cells. Sulfate magnesium can prevent posthypoxic brain injury by blocking glutamate receptors within the calcium (Ca++) ion channel. We used sulfate magnesium in nine newborn infant after perinatal hypoxia. We investigated the brain damage, by ultrasound examination, on third day, in first, second and third week, and third, sixth month of life. We have estimated the neurological development in the first week of life and third and twelfth month of life. We did not find deviations in ultrasound examination. We did not observe convulsions. We did not observe any side effect of this therapy. The examination at 1 of year of life in all of children was correct.
authors.affiliation: Polish Mother's Health Center, Department of Neonatology, Lódź, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Maroszyńska
authors.forename: B
authors.initials: B
authors.lastname: Sobolewska
authors.forename: E
authors.initials: E
authors.lastname: Gulczyńska
authors.forename: L
authors.initials: L
authors.lastname: Zylińska
authors.forename: E
authors.initials: E
authors.lastname: Lerch
authors.forename: M
authors.initials: M
authors.lastname: Kicińska
authors.forename: M
authors.initials: M
authors.lastname: Rudecka
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001921:Brain / Q000473:pathology*; D016923:Cell Death / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008278:Magnesium Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male
chemical_list: D008278:Magnesium Sulfate