title: Plasma Lp(a) values in familial hypercholesterolemia and its relation to coronary heart disease.
abstract: OBJECTIVE
  To analyze plasma Lp(a) levels and examine different risk factors and coronary heart disease (CHD) in a sample of genetically diagnosed familial hypercholesterolemia (FH) patients.
  
  
  RESULTS
  Ninety heterozygous FH patients and 41 non-FH relatives were enrolled in a study to evaluate their plasma and lipoprotein cholesterol, as well as their triglyceride and Lp(a) levels. We found no differences in plasma Lp(a) levels and log transformed values between 90 FH subjects and their 41 unaffected relatives (22.3 mg/dl +/- 19.4 vs 17.7 mg/dl +/- 21.3 and 1.12 +/- 0.5 vs 0.96 +/- 0.54) nor between null allele and defective allele FH subjects (log Lp (a) levels 2.013 +/- 0.282 vs 1.959 +/- 0.151). FH CHD+ were significantly older, and had higher mean systolic and diastolic blood pressure and higher mean plasma triglyceride levels than FH CHD-. No differences in mean and log transformed Lp(a) plasma concentrations were found.
  
  
  CONCLUSIONS
  Plasma Lp(a) levels are not related to LDL receptor status and class mutations, nor to the presence of CHD in FH patients.
authors.affiliation: Endocrine Service, Hospital Clinico Universitario, University of Valencia, Spain.
authors.forename: J T
authors.initials: JT
authors.lastname: Real
authors.forename: J F
authors.initials: JF
authors.lastname: Ascaso
authors.forename: F J
authors.initials: FJ
authors.lastname: Chaves
authors.forename: S
authors.initials: S
authors.lastname: Tenés
authors.forename: M A
authors.initials: MA
authors.lastname: Priego
authors.forename: O
authors.initials: O
authors.lastname: Puig
authors.forename: M E
authors.initials: ME
authors.lastname: Armengod
authors.forename: R
authors.initials: R
authors.lastname: Carmena
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000235:genetics*; D017270:Lipoprotein(a) / Q000009:adverse effects / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: D008078:Cholesterol, LDL; D017270:Lipoprotein(a)