Susceptibilities of oral and nasal isolates of Streptococcus mitis and Streptococcus oralis to macrolides and PCR detection of resistance genes.
The susceptibility of viridans group streptococci to macrolides was determined. Thirteen isolates (17%) were resistant to erythromycin. Five strains carried an erm gene that was highly homologous to that in Tn917. Four strains had mefE genes that coded erythromycin efflux ability.
Ono
T
T
Department of Microbiology, Tokushima University School of Dentistry, Tokushima 770-8504, Japan. ono@dent.tokushima-u.ac.jp
Shiota
S
S
Hirota
K
K
Nemoto
K
K
Tsuchiya
T
T
Miyake
Y
Y
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D004269:DNA, Bacterial / Q000187:drug effects / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D005798:Genes, Bacterial / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009055:Mouth / Q000382:microbiology*; D009296:Nasal Cavity / Q000382:microbiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013291:Streptococcus / Q000187:drug effects* / Q000235:genetics; D019533:Streptococcus oralis / Q000187:drug effects* / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D000900:Anti-Bacterial Agents; D002352:Carrier Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D004917:Erythromycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase