Hypoglycaemic and other related actions of Tinospora cordifolia roots in alloxan-induced diabetic rats.
Tinospora cordifolia is widely used in Indian Ayurvedic medicine for treating diabetes mellitus. Oral administration of an aqueous T. cordifolia root extract (TCREt) to alloxan diabetic rats caused a significant reduction in blood glucose and brain lipids. The extract caused an increase in body weight, total haemoglobin and hepatic hexokinase. The root extract also lowers hepatic glucose-6-phosphatase and serum acid phosphatase, alkaline phosphatase, and lactate dehydrogenase in diabetic rats. Thus TCREt has hypoglycaemic and hypolipidaemic effect.
Stanely
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P
Department of Biochemistry, Annamalai University, Annamalai Nagar, India.
Prince
M
M
Menon
V P
VP
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000201:enzymology; D004798:Enzymes / Q000097:blood / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007194:India; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010743:Phospholipids / Q000097:blood; D018517:Plant Roots; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D004798:Enzymes; D005230:Fatty Acids, Nonesterified; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D010743:Phospholipids; D002784:Cholesterol