Electrochemical study on the determination of tinidazole in tablets.
The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8-11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH < 4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton-Robinson buffer of pH 3.0, which allows quantification over the range 0.03-7.30 microg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.
Abu Zuhri
A Z
AZ
Chemistry Department, An-Najah National University, Nablus, Palestine. abuzuhri@najah.edu
Al-Khalil
S
S
Shubietah
R M
RM
El-Hroub
I
I
D000994:Antitrichomonal Agents / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D010084:Oxidation-Reduction; D010472:Perchlorates; D011048:Polarography / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D013607:Tablets / Q000032:analysis*; D014011:Tinidazole / Q000032:analysis*
D000994:Antitrichomonal Agents; D010472:Perchlorates; D013607:Tablets; D014011:Tinidazole