title: Effects of Re-arterialization on early graft function and regeneration in the rat model of heterotopic auxiliary liver transplantation.
abstract: In the rat model of heterotopic auxiliary liver transplantation, graft re-arterialization may influence the outcome of inter-liver competition. This was investigated in the current study using two transplanted groups with or without graft re-arterialization. Immediately after reperfusion, the re-arterialized grafts showed significantly higher bile flow rate and bilirubin excretion than the grafts without re-arterialization. DNA synthesis rate was also increased more drastically in the re-arterialized group following the transplantation. Without re-arterialization, the rats developed more pronounced cytolysis and cholestasis. Among the long-term survivors, all healthy re-arterialized grafts regenerated, whereas 5/6 non-re-arterialized grafts atrophied. These data demonstrate that the re-arterialization increases graft survival by improving early hepatic function, enhancing regenerative response and preventing post-transplant biliary complications in this rat model.
authors.affiliation: Division of Experimental Surgery, Department of Surgery, University Hospital of Ghent, Belgium. yedong.fan@rug.ac.be
authors.forename: Y D
authors.initials: YD
authors.lastname: Fan
authors.forename: M
authors.initials: M
authors.lastname: Praet
authors.forename: B
authors.initials: B
authors.lastname: Vanzieleghem
authors.forename: D
authors.initials: D
authors.lastname: Vanwynsberghe
authors.forename: D
authors.initials: D
authors.lastname: Stoop
authors.forename: G
authors.initials: G
authors.lastname: Leroux-Roels
authors.forename: J
authors.initials: J
authors.lastname: Delanghe
authors.forename: B
authors.initials: B
authors.lastname: de Hemptinne
mesh_terms: D000818:Animals; D001646:Bile / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D006085:Graft Survival; D006499:Hepatic Artery / Q000601:surgery*; D008099:Liver / Q000098:blood supply / Q000503:physiopathology; D008115:Liver Regeneration; D016031:Liver Transplantation; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D016042:Transplantation, Heterotopic
chemical_list: D004247:DNA