title: The discovery and synthesis of highly potent, A2a receptor agonists.
abstract: A series of N6,2-disubstituted adenosine analogues have been synthesized and their functional activity measured against A2a and A1 receptors. Examples of compounds with both a lipophilic N6-substituent and amino-functionalized 2-position were highly active at the A2a receptor on the human neutrophil.
authors.affiliation: Medicinal Sciences, Glaxo Wellcome Medicines Research Centre, Stevenage, Herts, UK. ser0079@glaxowellcome.co.uk
authors.forename: S E
authors.initials: SE
authors.lastname: Keeling
authors.forename: F D
authors.initials: FD
authors.lastname: Albinson
authors.forename: B E
authors.initials: BE
authors.lastname: Ayres
authors.forename: P R
authors.initials: PR
authors.lastname: Butchers
authors.forename: C L
authors.initials: CL
authors.lastname: Chambers
authors.forename: P C
authors.initials: PC
authors.lastname: Cherry
authors.forename: F
authors.initials: F
authors.lastname: Ellis
authors.forename: G B
authors.initials: GB
authors.lastname: Ewan
authors.forename: M
authors.initials: M
authors.lastname: Gregson
authors.forename: J
authors.initials: J
authors.lastname: Knight
authors.forename: K
authors.initials: K
authors.lastname: Mills
authors.forename: P
authors.initials: P
authors.lastname: Ravenscroft
authors.forename: L H
authors.initials: LH
authors.lastname: Reynolds
authors.forename: S
authors.initials: S
authors.lastname: Sanjar
authors.forename: M J
authors.initials: MJ
authors.lastname: Sheehan
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D019204:GTP-Binding Proteins; D058906:Purinergic P1 Receptor Agonists; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D058906:Purinergic P1 Receptor Agonists; D019204:GTP-Binding Proteins; D000241:Adenosine