title: Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: mimic of Hodgkin disease in nodal metastases.
abstract: We present the clinical and pathologic findings of a case of sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid in a 39-year-old woman. This particular case is notable because it initially presented as a cervical lymph node metastasis, and the initial clinical and histologic impression was Hodgkin disease, nodular sclerosis type. Sclerosing mucoepidermoid carcinoma with eosinophilia is a differentiated malignant neoplasm of the thyroid that can be confused with anaplastic carcinoma, medullary carcinoma, squamous cell carcinoma, or, as in this case, Hodgkin disease. A correct diagnosis of sclerosing mucoepidermoid carcinoma with eosinophilia involves awareness of this entity and appropriate immunohistochemical analysis. In this article, we briefly review the literature and stress the histologic and cytologic findings characteristic of sclerosing mucoepidermoid with eosinophilia of the thyroid.
authors.affiliation: Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Solomon
authors.forename: Z W
authors.initials: ZW
authors.lastname: Baloch
authors.forename: K E
authors.initials: KE
authors.lastname: Salhany
authors.forename: S
authors.initials: S
authors.lastname: Mandel
authors.forename: R S
authors.initials: RS
authors.lastname: Weber
authors.forename: V A
authors.initials: VA
authors.lastname: LiVolsi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D018277:Carcinoma, Mucoepidermoid / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D009333:Neck / Q000473:pathology; D037981:Neck Dissection; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor