[Apudocytes and mast cells in chronic inflammation of colon: clinicomorphological correlations].
OBJECTIVE
To study functional morphology of a total population of endocrine cells of colon mucosa, mast and enterochromaffine cells.


METHODS
Light and electrone microscopy, immunohistochemical methods, morphometry were used to study endocrine and mast cells of the sigmoid colon in inflammation.


RESULTS
Changes of functional morphology and size of endocrine and mast cell population as well as apudocytes producing serotonin, melatonin, vasointestinal peptides were stated. Apudocyte and mass cell functional morphology, clinical symptoms and mucosal structural changes correlated. Specificity of some parameters in Chron's disease is shown.


CONCLUSIONS
The results may provide additional criteria in diagnosis of different variants of chronic colitis.
Kozlova
I V
IV
Osadchuk
M A
MA
Kvetnoĭ
I M
IM
Popuchiev
V V
VV
D001078:APUD Cells / Q000378:metabolism / Q000648:ultrastructure*; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003092:Colitis / Q000378:metabolism / Q000473:pathology; D003424:Crohn Disease / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000648:ultrastructure*; D008407:Mast Cells / Q000378:metabolism / Q000648:ultrastructure*; D008550:Melatonin / Q000378:metabolism; D008875:Middle Aged; D011379:Prognosis; D012701:Serotonin / Q000378:metabolism; D012810:Sigmoid Diseases / Q000378:metabolism / Q000473:pathology*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D008550:Melatonin