title: Hypothalamic vasopressin gene expression increases in both males and females postpartum in a biparental rodent.
abstract: In previous studies, the closely related neuropeptide hormones oxytocin and vasopressin have been implicated in the central mediation of parental behaviour. Several studies in rats and sheep have demonstrated a role for oxytocin in the initiation of maternal behaviour. Recently, a few studies in a biparental species, the prairie vole (Microxytocinus ochrogaster) have suggested that vasopressin is important for paternal care. The present study investigated this latter possibility by measuring changes in vasopressin and oxytocin hypothalamic gene expression 1 day and 6 days following parturition in prairie voles which show paternal care and in montane voles (M. montanus) which lack paternal care. In prairie voles, vasopressin gene expression increased in both males and females postpartum, relative to sexually naive controls. In the non-paternal montane vole, no change in vasopressin gene expression was observed in either sex. In contrast to this species difference in vasopressin gene expression, hypothalamic oxytocin gene expression increased in both prairie and montane vole females, but not in males of either species. To augment measures of gene expression, we assessed vasopressin (V1a) and oxytocin receptor binding in both species. Although forebrain vasopressin V1a receptor binding was not altered following parturition in either species, oxytocin receptor binding increased in the ventromedial nucleus of the hypothalamus in females, but not males, in both prairie and montane voles. In summary, vasopressin gene expression increases in both males and females postpartum in a biparental species and oxytocin gene expression and receptor binding increase selectively in females. These results are consistent with earlier reports of a role for vasopressin in paternal care and for oxytocin in maternal behaviour.
authors.affiliation: Department of Psychology and Neuroscience Program, Florida State University, Tallahassee, FL 32306-1270, USA.
authors.forename: Z X
authors.initials: ZX
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: L J
authors.initials: LJ
authors.lastname: Young
authors.forename: T R
authors.initials: TR
authors.lastname: Insel
mesh_terms: D000818:Animals; D003411:Arvicolinae; D005260:Female; D015870:Gene Expression / Q000502:physiology; D007031:Hypothalamus / Q000737:chemistry / Q000502:physiology*; D007457:Iodine Radioisotopes; D008297:Male; D008425:Maternal Behavior / Q000502:physiology*; D010121:Oxytocin / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry / Q000502:physiology; D010332:Paternal Behavior; D049590:Postpartum Period / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D011869:Radioligand Assay; D018045:Receptors, Oxytocin / Q000032:analysis / Q000378:metabolism; D017483:Receptors, Vasopressin / Q000032:analysis / Q000378:metabolism; D012737:Sex Factors; D013495:Supraoptic Nucleus / Q000737:chemistry / Q000502:physiology; D014667:Vasopressins / Q000235:genetics* / Q000378:metabolism / Q000494:pharmacology; D014697:Ventromedial Hypothalamic Nucleus / Q000737:chemistry / Q000502:physiology
chemical_list: D007457:Iodine Radioisotopes; D012333:RNA, Messenger; D018045:Receptors, Oxytocin; D017483:Receptors, Vasopressin; D014667:Vasopressins; D010121:Oxytocin