New cytotoxic agents, BE-54238A and B, produced by a streptomycete.
New cytotoxic substances, designated BE-54238A and B, were isolated from the culture broth of Streptomyces sp. A54238. The active principles were extracted from the mycelium by methanol and purified by Diaion HP-20 and Sephadex LH-20 column chromatographies. BE-54238A and B exhibited cytotoxic activity against murine and human tumor cell lines.
Tsukamoto
M
M
Exploratory Research Laboratories, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd, Japan.
Nakajima
S
S
Murooka
K
K
Hirayama
M
M
Hirano
K
K
Yoshida
S
S
Kojiri
K
K
Suda
H
H
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use*; D005285:Fermentation; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use*; D013302:Streptomyces; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; C406045:BE 54238B; D011763:Pyrrolizidine Alkaloids; C406044:BE 54238A