Evaluation of the aldosterone synthase (CYP11B2) gene polymorphism in patients with myocardial infarction.
Left ventricular remodeling after myocardial infarction involves activation of the renin-angiotensin-aldosterone system. Recently, the biallelic -344T/C polymorphism of the aldosterone synthase gene was associated with increased aldosterone levels, arterial hypertension, diastolic dysfunction, and left ventricular dilatation. We hypothesized that this polymorphism may also affect left ventricular geometry and function after myocardial infarction. By using a standardized questionnaire, as well as anthropometric and echocardiographic measurements, we thus studied 606 patients (533 men and 73 women) who had a myocardial infarction before the age of 60 years. The aldosterone synthase gene polymorphism was analyzed after polymerase chain reaction amplification and restriction enzyme digestion. The results demonstrated that there was no association of the aldosterone synthase gene polymorphism with echocardiographically determined left ventricular dimensions, wall thicknesses, or indexes of systolic or diastolic function. Furthermore, anthropometric data, including blood pressure levels, were balanced between the different genotypes. Finally, the allele frequency was similar for patients with myocardial infarction and a sample group from the normal population (n=1675). The data indicate that the allele status of the aldosterone synthase gene polymorphism is not useful for the identification of patients with myocardial infarction who have impaired left ventricular function or unfavorable remodeling.
Hengstenberg
C
C
Klinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, Germany. christian.hengstenberg@klinik.uni-reg ensburg.de
Holmer
S R
SR
Mayer
B
B
Löwel
H
H
Engel
S
S
Hense
H W
HW
Riegger
G A
GA
Schunkert
H
H
D000483:Alleles; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006352:Heart Ventricles / Q000201:enzymology; D006801:Humans; D006973:Hypertension / Q000235:genetics; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D009206:Myocardium / Q000201:enzymology; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics; D012307:Risk Factors
D019405:Cytochrome P-450 CYP11B2