L-myc polymorphism in cancer patients, healthy blood donors and elderly, tumor-free individuals in Russia.
L-myc polymorphism was investigated in 95 breast cancer (BC), 63 colorectal cancer (CC) and 58 lung cancer (LC) patients, as well as in 122 healthy, middle-aged blood donors (HBDs) and 184 elderly, tumor-free individuals. The occurrence of the S allele in the BC cohort (57%) was significantly higher than that in middle-aged, healthy females (41%) and elderly, non-affected women (47%), implying involvement of the L-myc genotype in BC susceptibility (age-adjusted OR = 1.74, 95% CI 1.11-2.73, p = 0.016). L-myc allele distribution in CC and LC was similar to that in controls. Contrary to earlier reports, L:S allele frequencies ratio in elderly blood donors (EBDs) did not significantly differ from that in HBDs (0.49:0. 51 and 0.54:0.46, respectively). However, the S allele had a tendency to be over-represented among elderly compared with middle-aged smokers (55% vs. 44%; OR = 1.57, 95% CI 0.98-2.50, p = 0. 059), which implies that it may be linked with tolerance to smoking effects.
Togo
A V
AV
Group of Molecular Diagnostics, N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Suspitsin
E N
EN
Grigoriev
M Y
MY
Ilyushik
E S
ES
Karpova
M B
MB
Hanson
K P
KP
Imyanitov
E N
EN
D000328:Adult; D000368:Aged; D001773:Blood Cells / Q000737:chemistry; D001782:Blood Donors; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D016259:Genes, myc; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008136:Longevity / Q000235:genetics; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012426:Russia / Q000453:epidemiology; D012907:Smoking / Q000235:genetics