title: Neural and local effects of hypoxia on cardiovascular responses to obstructive apnea.
abstract: Obstructive sleep apnea (OSA) acutely increases systemic (Psa) and pulmonary (Ppa) arterial pressures and decreases ventricular stroke volume (SV). In this study, we used a canine model of OSA (n = 6) to examine the role of hypoxia and the autonomic nervous system (ANS) in mediating these cardiovascular responses. Hyperoxia (40% oxygen) completely blocked any increase in Ppa in response to obstructive apnea but only attenuated the increase in Psa. In contrast, after blockade of the ANS (20 mg/kg iv hexamethonium), obstructive apnea produced a decrease in Psa (-5.9 mmHg; P < 0.05) but no change in Ppa, and the fall in SV was abolished. Both the fall in Psa and the rise in Ppa that persisted after ANS blockade were abolished when apneas were induced during hyperoxia. We conclude that 1) hypoxia can account for all of the Ppa and the majority of the Psa response to obstructive apnea, 2) the ANS increases Psa but not Ppa in obstructive apnea, 3) the local effects of hypoxia associated with obstructive apnea cause vasodilation in the systemic vasculature and vasoconstriction in the pulmonary vasculature, and 4) a rise in Psa acts as an afterload to the heart and decreases SV over the course of the apnea.
authors.affiliation: Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.
authors.forename: H
authors.initials: H
authors.lastname: Schneider
authors.forename: C D
authors.initials: CD
authors.lastname: Schaub
authors.forename: C A
authors.initials: CA
authors.lastname: Chen
authors.forename: K A
authors.initials: KA
authors.lastname: Andreoni
authors.forename: A R
authors.initials: AR
authors.lastname: Schwartz
authors.forename: P L
authors.initials: PL
authors.lastname: Smith
authors.forename: J L
authors.initials: JL
authors.lastname: Robotham
authors.forename: C P
authors.initials: CP
authors.lastname: O'Donnell
mesh_terms: D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D002319:Cardiovascular System / Q000503:physiopathology*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000502:physiology; D018738:Hexamethonium / Q000494:pharmacology; D018496:Hyperoxia / Q000150:complications / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications* / Q000503:physiopathology*; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology; D015656:Respiratory Mechanics / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology*; D013318:Stroke Volume / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
chemical_list: D018738:Hexamethonium