title: Automated analysis of digital oximetry in the diagnosis of obstructive sleep apnoea.
abstract: BACKGROUND
  The gold standard diagnostic test for obstructive sleep apnoea (OSA) is overnight polysomnography (PSG) which is costly in terms of time and money. Consequently, a number of alternatives to PSG have been proposed. Oximetry is appealing because of its widespread availability and ease of application. The diagnostic performance of an automated analysis algorithm based on falls and recovery of digitally recorded oxygen saturation was compared with PSG.
  
  
  METHODS
  Two hundred and forty six patients with suspected OSA were randomly selected for PSG and automated off line analysis of the digitally recorded oximeter signal.
  
  
  RESULTS
  The PSG derived apnoea hypopnea index (AHI) and oximeter derived respiratory disturbance index (RDI) were highly correlated (R = 0.97). The mean (2SD) of the differences between AHI and RDI was 2.18 (12.34)/h. The sensitivity and specificity of the algorithm depended on the AHI and RDI criteria selected for OSA case designation. Using case designation criteria of 15/h for AHI and RDI, the sensitivity and specificity were 98% and 88%, respectively. If the PSG derived AHI included EEG based arousals as part of the hypopnea definition, the mean (2SD) of the differences between RDI and AHI was -0.12 (15. 62)/h and the sensitivity and specificity profile did not change significantly.
  
  
  CONCLUSIONS
  In a population of patients suspected of having OSA, off line automated analysis of the oximetry signal provides a close estimate of AHI as well as excellent diagnostic sensitivity and specificity for OSA.
authors.affiliation: Division of Respiratory Medicine, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1.
authors.forename: J C
authors.initials: JC
authors.lastname: Vázquez
authors.forename: W H
authors.initials: WH
authors.lastname: Tsai
authors.forename: W W
authors.initials: WW
authors.lastname: Flemons
authors.forename: A
authors.initials: A
authors.lastname: Masuda
authors.forename: R
authors.initials: R
authors.lastname: Brant
authors.forename: E
authors.initials: E
authors.lastname: Hajduk
authors.forename: W A
authors.initials: WA
authors.lastname: Whitelaw
authors.forename: J E
authors.initials: JE
authors.lastname: Remmers
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010092:Oximetry / Q000379:methods*; D017286:Polysomnography / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012891:Sleep Apnea Syndromes / Q000175:diagnosis*