title: A comparison between in vitro studies of protein lesions generated by brain electrodes and finite element model simulations.
abstract: The aim of this study was to develop a finite element model for simulation of the thermal characteristics of brain electrodes and to compare its performances with an in vitro experimental albumin model. Ten lesions were created in albumin using a monopolar electrode connected to a Leksell Neuro Generator and a computer-assisted video system was used to determine the size of the generated lesions. A finite element model was set up of the in vitro experiments using the same thermal properties. With a very simple heat source applied to the finite element model in the proximity of the upper part of the tip, a good agreement (no deviations in width and distance from tip but a deviation in length of -1.6 mm) with the in vitro experiments (width 4.6 +/- 0.1 mm and length 7.4 +/- 0.1 mm) was achieved when comparing the outline of the lesion. In addition, a gelatinous albumin-model was set up and compared to computer simulations resulting in deviations in width of -0.4 mm, length of -2.2 mm and distance from the tip of -0.1 mm. Hence, the utilisation of finite element model simulations may be a useful complement to in-vitro experiments.
authors.affiliation: Department of Biomedical Engineering, Linköping University, Sweden. olaer@imt.liu.se
authors.forename: O
authors.initials: O
authors.lastname: Eriksson
authors.forename: J
authors.initials: J
authors.lastname: Wren
authors.forename: D
authors.initials: D
authors.lastname: Loyd
authors.forename: K
authors.initials: K
authors.lastname: Wårdell
mesh_terms: D000418:Albumins; D001921:Brain / Q000601:surgery*; D003198:Computer Simulation; D004598:Electrosurgery; D020342:Finite Element Analysis; D066298:In Vitro Techniques; D008839:Microelectrodes; D008959:Models, Neurological; D009069:Movement Disorders / Q000601:surgery
chemical_list: D000418:Albumins