Computerized reminders to monitor liver function to improve the use of etretinate.
OBJECTIVE
to determine whether computerized reminders during the process of prescribing can improve the use of drugs requiring prior laboratory testing according to the indications listed in the Drug Package Insert.


METHODS
Change in proportion of appropriate prescribing and frequency of severe hepatotoxicity between pre- and post-intervention.


METHODS
etretinate, a medication indicated for psoriasis, was selected as a monitored drug because it was the most prescribed of all the identified drugs that require specific prior laboratory tests. Computerized reminders are designed to alert a physician who is about to prescribe etretinate either without the alanine aminotransferase (ALT) test or the aspartate aminotransferase (AST) test within 3 months or despite abnormality in ALT or AST. Data on alerts were gathered by using electronic mail whenever alerts occurred.


RESULTS
prescriptions of etretinate with normal ALT or AST results within the previous three months increased suddenly from 25.9% (127/491) in the pre-intervention period to 66.2% (353/533) in the post-intervention period (P < 0.0001). Moreover, three patients who used etretinate had markedly abnormal tests in the pre-intervention period, but none of the patients were classified in this way in the post-intervention period.


CONCLUSIONS
the computerized reminders appear to improve physicians' use of a drug requiring specific prior laboratory tests.
Koide
D
D
Department of Pharmacoepidemiology, Faculty of Medicine, University of Tokyo, Japan. koide@hcc.h.u-tokyo.ac.jp
Ohe
K
K
Ross-Degnan
D
D
Kaihara
S
S
D056486:Chemical and Drug Induced Liver Injury; D003195:Computer Communication Networks; D011307:Drug Prescriptions / Q000592:standards*; D005050:Etretinate / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008107:Liver Diseases / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011787:Quality of Health Care / Q000458:organization & administration; D017010:Reminder Systems
D007641:Keratolytic Agents; D005050:Etretinate