Studies on anti-folate antimalarials in east Africa.
Chlorproguanil-dapsone (CD) appears to be a promising anti-folate combination (Amukoye et al., 1997) to substitute for pyrimethamine-sulfadoxine (PS), which has a long half-life and against which there is resistance in several Plasmodium falciparum populations including the highly endemic lowland area near Muheza, Tanzania (Trigg et al., 1997).
Ortelli
F
F
London School of Hygiene and Tropical Medicine, UK.
Maxwell
C A
CA
Curtis
J
J
Watkins
W M
WM
D000351:Africa, Eastern; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D003622:Dapsone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005493:Folic Acid Antagonists / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy*; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000031:analogs & derivatives / Q000627:therapeutic use; D011739:Pyrimethamine / Q000627:therapeutic use; D013413:Sulfadoxine / Q000627:therapeutic use
D000962:Antimalarials; D005493:Folic Acid Antagonists; D013413:Sulfadoxine; C007030:chlorproguanil; D003622:Dapsone; D002727:Proguanil; D011739:Pyrimethamine