title: Recurrent detoxification may elevate alcohol craving as measured by the Obsessive Compulsive Drinking scale.
abstract: Research has demonstrated a relationship between the number of previous alcohol detoxifications and increased severity of the alcohol withdrawal syndrome (AWS) that is hypothesized to be similar to an electrophysiologic "kindling process." Application of a "kindling" model to AWS suggests that neuroadaptation of the central nervous system to repeated detoxifications may also cause neurobehavioral alterations that may affect "craving." This study examined craving as assessed by the Obsessive Compulsive Drinking Scale (OCDS) in 67 adult outpatients meeting DSM-IV criteria (American Psychiatric Association, 1994) for alcohol dependence and AWS having either < 2 and > or = 2 previous detoxifications. Results of ANCOVA revealed that patients with > or = 2 previous detoxifications had higher scores on a scale that measures obsessive thoughts about alcohol, drinking urges and behaviors, and a composite of these scores after controlling for alcohol dependence severity, depressive symptoms and number of drinks 2 weeks prior to the study. Findings emphasize the need to address craving and other psychological variables with respect to treatment of AWS.
authors.affiliation: Medical University of South Carolina, Alcohol Research Center, Charleston 29425, USA. malcolmr@musc.edu
authors.forename: R
authors.initials: R
authors.lastname: Malcolm
authors.forename: J E
authors.initials: JE
authors.lastname: Herron
authors.forename: R F
authors.initials: RF
authors.lastname: Anton
authors.forename: J
authors.initials: J
authors.lastname: Roberts
authors.forename: J
authors.initials: J
authors.lastname: Moore
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000523:psychology*; D000437:Alcoholism / Q000523:psychology* / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000523:psychology