Free-Wilson analysis of the antibacterial activity of fluoronaphthyridines against various microbes. A new application of indicator variables.
The quantitative structure-activity relationship of the antibacterial activity of eighteen fluoronaphthyridines against nine species of bacteria was analyzed by the Free-Wilson method. A new indicator variable, which designates the species of bacteria, was useful in predicting the antibacterial activity against the various microbes.
Terada
Y
Y
Faculty of Pharmacy, Meijo University, Nagoya, Japan. yterada@meijo-u.ac.jp
Nanya
K
K
D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003627:Data Interpretation, Statistical; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D009287:Naphthyridines