Some hormonal changes before and after vertical banded gastroplasty for severe obesity.
BACKGROUND
Hormonal disturbances play a role in the development of obesity, but may be a consequence of obesity itself. In this study we assessed the influence of the surgically-induced weight loss on some important hormonal abnormalities in the morbidly obese patients.


METHODS
Fasting serum prolactin, insulin, cortisol and thyroid hormones: free thyroxin (FT4), free triiodothyronine (FT3) and thyrotropin (TTH), have been studied by radioimmune methods before vertical banded gastroplasty (VBG) and after operation in the early (10-14 days) and late period when excess weight loss (EWL) 51.7-57.1% had been achieved.


RESULTS
On the 10-14 day after VBG, prolactin increased significantly in women (p<0.05), but decreased after weight loss (p<0.01). Fasting insulin was lowered significantly (p<0.05) soon after VBG in the hyperinsulinemic (51.7% of the total group) and diabetic (n-9) patients. After weight loss, insulin decreased significantly (p<0.0001) vs. preoperative. Concentration of cortisol was unchanged both in the early and in the late postoperative period. On the days 10-14, significant elevation of TTH and decrease of FT3 (p<0.05) have been noted. After essential weight loss TTH dropped significantly vs. preoperative (p<0.05) with no changes in FT3 and FT4 concentration.


CONCLUSIONS
VBG and consequent weight loss favorably influence the hormonal abnormalities in the morbidly obese. Further studies are needed to make clear a relationship between this and other parameters of metabolic syndrome. The hormonal abnormalities may influence the indications for surgery in less than morbidly obese patients with metabolic syndrome.
Yashkov
Y I
YI
Department of Liver, Bile Ducts and Pancreatic Surgery, Russian Research Center of Surgery, Moscow.
Vinnitsky
L I
LI
Poroykova
M V
MV
Vorobyova
N T
NT
D000328:Adult; D005260:Female; D015391:Gastroplasty; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000601:surgery*; D011388:Prolactin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D015431:Weight Loss
D006728:Hormones; D007328:Insulin; D013963:Thyroid Hormones; D011388:Prolactin; D006854:Hydrocortisone