ACE inhibitors suppress ischemia-induced arrhythmias by reducing the spatial dispersion of ventricular repolarization.
The effect of angiotensin-converting enzyme (ACE) inhibitors on ischemia-induced spatial dispersion of ventricular repolarization was investigated in 12 pentobarbitone-anesthetized sheep. The obtuse marginal coronary artery was occluded in the pretreated animals (enalapril maleate, 0.4 mg/kg, i.v., n = 6) and controls (normal saline, i.v., n = 6). The activation-recovery intervals were determined from the unipolar ECGs acquired from the ischemic region. There was a significant increase in the pooled activation-recovery interval dispersion in both groups at 30 min of coronary occlusion (p < 0.01), however, the increase in the treatment group was smaller than that of the controls (15.9 +/- 9.7 vs. 43.6 +/- 19.9 ms, p < 0. 01). Ventricular ectopic beats were observed in the 6 controls and in only 1 pretreated animal.


CONCLUSIONS
ACE inhibitors suppress the spatial dispersion of ventricular repolarization and this may be attributed to, at least in part, its antiarrhythmic effect.
Wang
L
L
School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia. lwang@csu.edu.au
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D003327:Coronary Disease; D004562:Electrocardiography; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications* / Q000188:drug therapy; D012756:Sheep; D016276:Ventricular Function / Q000187:drug effects* / Q000502:physiology; D018879:Ventricular Premature Complexes / Q000517:prevention & control
D000806:Angiotensin-Converting Enzyme Inhibitors; D004656:Enalapril