Histologic observations of periodontal wound healing after treatment with PerioGlas in nonhuman primates.
The effect of PerioGlas (synthetic bone particulate) on wound healing of experimental palatal periodontal defects in monkeys was evaluated. Chronic periodontal defects were created on the palatal aspects of maxillary molars and premolars. Open-flap debridement was performed. Experimental sites received PerioGlas, while control sites received no further treatment. Histologic measurements were performed on new bone, new cementum, epithelial downgrowth, and recession. Results showed significantly more new cementum and less epithelial downgrowth in the sites that received PerioGlas (P < 0.05). The present results indicate that PerioGlas may enhance periodontal wound healing outcomes.
Karatzas
S
S
Department of Periodontology and Oral Biology, Boston University, Massachusetts 02118, USA.
Zavras
A
A
Greenspan
D
D
Amar
S
S
D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D002516:Ceramics / Q000494:pharmacology*; D008253:Macaca mulatta; D008297:Male; D014945:Wound Healing / Q000187:drug effects*
C022107:Bioglass; D018786:Bone Substitutes