Vaccination against malaria: targets, strategies and potentiation of immunity to blood stage parasites.
Malaria is the world's major parasitic disease, for which effective control measures are urgently needed. One of the difficulties hindering successful vaccine design against Plasmodium is an incomplete knowledge of antigens eliciting protective immunity, the precise types of immune response for which to aim, and how these can be induced. A greater appreciation of the mechanisms of protective immunity, on the one hand, and of immunopathology, on the other, should provide critical clues to how manipulation of the immune system may best be achieved. This review discusses the current state of malaria vaccine development and research to understand the factors involved in the modulation of vaccine-potentiated immunity to the pathogenic blood-borne stages of the parasite.
Taylor-Robinson
A W
AW
School of Biology, University of Leeds, Leeds, United Kingdom. bgyawtr@leeds.ac.uk
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology; D016207:Cytokines / Q000276:immunology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D007109:Immunity; D008288:Malaria / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control* / Q000628:therapy; D017780:Malaria Vaccines / Q000276:immunology / Q000627:therapeutic use*; D010961:Plasmodium / Q000276:immunology / Q000502:physiology; D019444:Vaccines, DNA / Q000276:immunology / Q000627:therapeutic use
D000953:Antigens, Protozoan; D016207:Cytokines; D017780:Malaria Vaccines; D019444:Vaccines, DNA