The 5 alpha-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations.
The methanol extract of heartwood of Artocarpus incisus showed potent 5 alpha-reductase inhibitory activity. We investigated the 5 alpha-reductase inhibitory effects of nine compounds isolated from A. incisus. Chlorophorin (IC50 = 37 microM) and artocarpin (IC50 = 85 microM) showed more potent inhibitory effects than did alpha-linolenic acid, which is known as a naturally occurring potent inhibitor. Structure-activity investigations suggested that the presence of an isoprene substituent (prenyl and geranyl) would enhance 5 alpha-reductase inhibitory effects.
Shimizu
K
K
Department of Forest Products, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Fukuda
M
M
Kondo
R
R
Sakai
K
K
D058891:5-alpha Reductase Inhibitors; D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D014197:Trees / Q000737:chemistry*
D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors