title: Isolation of iso-grayanotoxin II from leaves of Leucothoe grayana Max. Its X-ray crystallographic analysis and acute toxicity in mice.
abstract: The structure of iso-grayanotoxin II, a new diterpenoid from Leucothoe grayana MAX., has been determined as 3 beta,5 beta,6 beta,14 beta,16 alpha-pentahydroxygrayanotox-9(10)-ene by spectroscopic and X-ray crystallographic analysis. The lethal dosage level of iso-grayanotoxin II in mice was lower than that of grayanotoxin III.
authors.affiliation: Department of Applied Chemistry, Osaka Institute of Technology, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Terai
authors.forename: D
authors.initials: D
authors.lastname: Araho
authors.forename: K
authors.initials: K
authors.lastname: Osakabe
authors.forename: M
authors.initials: M
authors.lastname: Katai
authors.forename: I
authors.initials: I
authors.lastname: Narama
authors.forename: T
authors.initials: T
authors.lastname: Matsuura
authors.forename: J
authors.initials: J
authors.lastname: Katakawa
authors.forename: T
authors.initials: T
authors.lastname: Tetsumi
authors.forename: M
authors.initials: M
authors.lastname: Sato
mesh_terms: D000818:Animals; D002849:Chromatography, Gas; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D007536:Isomerism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry*; D010947:Plants, Toxic / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014118:Toxins, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D004224:Diterpenes; D014118:Toxins, Biological; C020750:grayanotoxin II