title: Clear cell syringoid carcinoma: an ultrastructural and immunohistochemical study.
abstract: Syringoid carcinoma (syringoid "eccrine" carcinoma or eccrine epithelioma) is a rare cutaneous tumor with some controversy regarding its correct definition. It may also be difficult to differentiate from its benign counterpart (syringoma), other adnexal carcinomas, and cutaneous metastasis from adenocarcinomas. We present a case of a syringoid carcinoma of the clear cell variant complemented with an immunohistochemical and ultrastructural study, the latter revealing cytoplasmic accumulation of glycogen and presence of intercellular and intracellular lumina in clear tumor cells, as well as diverse hallmarks of malignancy (i.e., perineural invasion, tumor necrosis, and deep invasion). Clear tumor cells showed cytoplasmic and membranous immunoreactivity to epithelial membrane antigen, carcinoembryonic antigen, keratins, and S-100. Our ultrastructural and immunohistochemical results support the ductal differentiation of the glycogen-filled clear cell tumor population.
authors.affiliation: Department of Pathology, Hospital Clínico Universitario, University of Valencia, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Ramos
authors.forename: C
authors.initials: C
authors.lastname: Monteagudo
authors.forename: C
authors.initials: C
authors.lastname: Carda
authors.forename: E
authors.initials: E
authors.lastname: Montesinos
authors.forename: J
authors.initials: J
authors.lastname: Ferrer
authors.forename: A
authors.initials: A
authors.lastname: Peydro-Olaya
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012535:Scalp; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D007633:Keratins