Discovery of the ceruloplasmin homologue hephaestin: new insight into the copper/iron connection.
Approximately 75 years ago Hart and colleagues discovered that copper deficiency impaired mammalian iron metabolism. Discovery of hephaestin identifies a critical new component of the copper and iron connection in mammals. Hephaestin appears to be a multicopper oxidase required for efficient export of iron from the intestine.
Eisenstein
R S
RS
Department of Nutritional Sciences, University of Wisconsin, Madison 53706, USA.
D002570:Ceruloplasmin / Q000378:metabolism*; D003300:Copper / Q000172:deficiency* / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D007501:Iron / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*
C492164:HEPH protein, human; D008565:Membrane Proteins; D003300:Copper; D007501:Iron; D002570:Ceruloplasmin