The Ets family member Erg gene is expressed in mesodermal tissues and neural crests at fundamental steps during mouse embryogenesis.
The Erg gene belongs to the Ets family encoding a class of transcription factors. To gain new insight on the in vivo functional specificity of the Erg gene within the wide Ets family, we used in situ hybridization to determine its expression pattern during murine embryogenesis. We found that the Erg gene expression predominates in mesodermal tissues, including the endothelial, precartilaginous and urogenital areas. A specific Erg gene expression was also identified in migrating neural crest cells. A comparison with Fli-1, the most closely Erg-related gene, revealed that both gene expressions partially overlap, suggesting that they may contribute to related functions in these tissues. Like other Ets family genes, Erg seems involved in several fundamental developmental steps in murine embryogenesis, including epithelio-mesenchymal transition, cell migration, settlement and differentiation.
Vlaeminck-Guillem
V
V
CNRS UMR 319, Institut de Biologie de Lille, BP447, 1 rue Calmette, 59021 Lille, cedex, France.
Carrere
S
S
Dewitte
F
F
Stehelin
D
D
Desbiens
X
X
Duterque-Coquillaud
M
M
D000818:Animals; D002465:Cell Movement; D004268:DNA-Binding Proteins / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics* / Q000502:physiology; D015870:Gene Expression; D008648:Mesoderm / Q000378:metabolism*; D051379:Mice; D009432:Neural Crest / Q000166:cytology / Q000378:metabolism*; D015513:Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics*; D051789:Proto-Oncogene Protein c-fli-1; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D000071230:Transcriptional Regulator ERG; D014566:Urogenital System
D004268:DNA-Binding Proteins; C072312:ERG protein, human; C497426:Fli1 protein, mouse; D015513:Oncogene Proteins; D051789:Proto-Oncogene Protein c-fli-1; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000071230:Transcriptional Regulator ERG