NK cell receptors: of missing sugar and missing self.
Natural killer cells in mice detect cells in distress using lectin-like receptors that bind to self-MHC class I molecules. A new co-crystal structure suggests how NK cell maturation and attack may be mediated by receptor interaction at two distinct sites on the MHC class I molecule, both involving glycosylation.
Parham
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Department of Structural Biology, Fairchild Building, Stanford University, Stanford, CA 94305-5400, USA. peropa@leland.stanford.edu.
D000818:Animals; D000950:Antigens, Ly; D001665:Binding Sites; D002241:Carbohydrates / Q000737:chemistry; D018360:Crystallography, X-Ray; D006031:Glycosylation; D007694:Killer Cells, Natural / Q000737:chemistry; D037181:Lectins, C-Type; D008285:Major Histocompatibility Complex; D051379:Mice; D008954:Models, Biological; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000502:physiology*; D055630:Receptors, NK Cell Lectin-Like
D000950:Antigens, Ly; D002241:Carbohydrates; D037181:Lectins, C-Type; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like