Medical therapy of supraesophageal gastroesophageal reflux disease.
Medical therapy of supraesophageal gastroesophageal reflux disease (GERD) is based on the principals for treating patients with heartburn and erosive esophagitis, observations from the few available clinical trials, and clinical experience. In general, patients with supraesophageal GERD require higher doses of antireflux therapy, principally with proton pump inhibitors, for longer periods of time to effectively relieve symptoms compared with patients with heartburn and/or erosive esophagitis. This article reviews the current literature and discusses a suggested approach to medical management of these often complex patients.
Katz
P O
PO
Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania 19146, USA.
Castell
D O
DO
D000465:Algorithms; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D004941:Esophagitis / Q000209:etiology / Q000628:therapy*; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy / Q000628:therapy*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006356:Heartburn / Q000209:etiology / Q000628:therapy*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008019:Life Style; D054328:Proton Pump Inhibitors
D004791:Enzyme Inhibitors; D005765:Gastrointestinal Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors