A case of Goodpasture's syndrome with massive pulmonary hemorrhage.
We present a typical case of Goodpasture's syndrome with massive pulmonary hemorrhage and acute deterioration of renal function. A 20-year-old male was admitted due to severe azotemia (blood urea nitrogen 214.7 mg/dL, serum creatinine 30.2 mg/dL) and was treated with emergency hemodialysis. On the 4th hospital day, a sudden onset of pulmonary hemorrhage developed. The circulating level of anti-glomerular basement membrane antibody was then elevated highly, and the kidney biopsy showed crescentic glomerulonephritis and linear deposition of IgG along the glomerular capillary. The patient was treated with intravenous high dose-steroid, oral cyclophosphamide and plasma exchanges. The pulmonary hemorrhage improved with the therapy, however, his renal function did not improve. He is currently on a regular schedule of hemodialysis.
Kim
Y O
YO
Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul.
Choi
J Y
JY
Park
J I
JI
Yoon
S A
SA
Yang
C W
CW
Hyoung
K
K
Bang
B K
BK
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications* / Q000503:physiopathology; D006469:Hemoptysis / Q000209:etiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male