title: [Diarrhea in a patient with Down syndrome and endemic sprue].
abstract: BACKGROUND
  Down syndrome is associated with disorders such as celiac disease, hypothyroidism, and insulin-dependent diabetes mellitus. In patients with mono- or oligosymptomatic celiac disease the time interval between the onset of symptoms and diagnosis often is unacceptably long.
  
  
  METHODS
  A female patient with Down syndrome is presented who had acute watery diarrhea, which spontaneously ceased but recurred after a few days. After endoscopic and histologic evaluation and measurement of gliadin, endomysium, and reticulin antibodies celiac sprue was diagnosed. Further investigation showed findings of autoimmune hypothyroidism and secondary hyperparathyreoidism. After the patient was put on a gluten-free diet her state quickly improved.
  
  
  CONCLUSIONS
  Associations between Down syndrome and autoimmune diseases exist. Patients with acute gastrointestinal symptoms should be evaluated as to celiac disease. The time interval between the onset of symptoms and diagnosis of celiac disease can be shortened, if all diagnostic tools are used at the appropriate time.
authors.affiliation: Medizinische Klinik, Ferdinand-Sauerbruch-Klinikum, Klinikum Wuppertal GmbH, Universität Witten-Herdecke.
authors.forename: G
authors.initials: G
authors.lastname: Micklefield
authors.forename: I U
authors.initials: IU
authors.lastname: Wenzel
mesh_terms: D001323:Autoantibodies / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology*; D004314:Down Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D008875:Middle Aged; D013967:Thyroiditis, Autoimmune / Q000175:diagnosis / Q000235:genetics / Q000473:pathology
chemical_list: D001323:Autoantibodies