title: Baicalein: an in vitro antigenotoxic compound from Scutellaria baicalensis.
abstract: Bioassay-guided fractionation of an H2O extract of the root of Scutellaria baicalensis has furnished an in vitro antigenotoxic flavonoid, baicalein (1) and 2',5,5',7-tetrahydroxy-6',8-dimethoxyflavone (2). Compound 1 exhibited a dose-dependent inhibition of aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine mutagenicity in the Salmonella typhimurium bacterial mutation assay. In the chromosome aberration assay, compound 1, at a concentration of 5 microM, reduced the frequency of chromosome aberration induced by AFB1 but increased the clastogenic effect of AFB1 at a concentration of 50 microM.
authors.forename: B H
authors.initials: BH
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: T H
authors.initials: TH
authors.lastname: Kang
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: D H
authors.initials: DH
authors.lastname: Sohn
authors.forename: G I
authors.initials: GI
authors.lastname: Ko
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
mesh_terms: D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors*; D016587:Antimutagenic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D016587:Antimutagenic Agents; D044950:Flavanones; D005419:Flavonoids; C006680:baicalein; D016604:Aflatoxin B1