title: Treatment of severe depression.
abstract: A significant minority of depressed outpatients and a vast majority of those hospitalized for depression can be considered severely ill. Severe depressive states are quite heterogeneous and include the more classical subforms (e.g., melancholia or psychotic depression) as well as various comorbid presentations. This article reviews the classification, phenomenology, pathophysiology, and treatment of severe depression.
authors.affiliation: University of Pittsburgh School of Medicine, PA, USA. thaseme@msx.upmc.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Thase
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D004359:Drug Therapy, Combination; D004565:Electroconvulsive Therapy; D006801:Humans; D010555:Personality Inventory / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011613:Psychotherapy; D012720:Severity of Illness Index
chemical_list: D000928:Antidepressive Agents