The effect of weight loss with or without exercise training on large artery compliance in healthy obese men.
BACKGROUND
Obesity is an independent risk factor for cardiovascular morbidity and mortality. Large artery compliance is thought to be associated with cardiovascular risk. The effect of weight loss on large artery compliance is not yet clarified.


OBJECTIVE
To investigate the effect of weight loss, with or without exercise, on vessel wall properties in healthy obese men.


METHODS
This was a pair-matched randomized intervention study. All subjects were on an energy-restricted diet. One subject from each pair was also on an exercise programme. Measurements were performed before and at the end of the study period. The study lasted for 3 months.


METHODS
The vessel wall properties of the brachial and common carotid artery were assessed using a vessel wall movement detector system in combination with applanation tonometry.


RESULTS
The mean body mass index was 32.3+/-0.4 kg/m2 and decreased (P < 0.001) to 27.6+/-0.4 kg/mm2 during the study. The mean blood pressure decreased (P < 0.001) by 6%. At operating pressures, carotid artery distensibility was 27.5+/-1.7 x 10(-3)/kPa at the start of the study and 31.1+/-1.8 x 10(-3)/kPa (P < 0.04) at the end of the study. Brachial and carotid artery compliances were 0.11+/-0.01 and 1.35+/-0.08 mm2/kPa at the start of the study and tended to increase to 0.12+/-0.001 (P = 0.06) and 1.48+/-0.08 mm2/kPa (P = 0.057), respectively, at the end of the study. Isobaric compliance did not change. The diet-and-exercise group did not differ statistically from the only-diet group in the effects on weight loss, blood pressure and arterial compliance.


CONCLUSIONS
This study shows that weight loss increased carotid artery distensibility at operating pressures, but not under isobaric conditions. This increase is probably due to the decrease in blood pressure. The addition of exercise did not result in an additional effect within 3 months.
Balkestein
E J
EJ
Department of Pharmacology, Maastricht University, The Netherlands. e.balkestein@farmaco.unimaas.nl
van Aggel-Leijssen
D P
DP
van Baak
M A
MA
Struijker-Boudier
H A
HA
Van Bortel
L M
LM
D000328:Adult; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D015992:Body Mass Index; D001916:Brachial Artery / Q000503:physiopathology; D002339:Carotid Arteries / Q000503:physiopathology; D004038:Diet, Reducing; D005081:Exercise Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome; D014666:Vasomotor System / Q000503:physiopathology*; D015431:Weight Loss