Henoch-Schonlein purpura and streptococcal infection: a prospective case-control study.
A prospective, matched, case-control study conducted over a period of 3 years was designed to examine the association of group A beta-haemolytic streptococcal infections and Henoch-Schonlein purpura. Demographic and clinical data were collected as well as measurement of antistreptolysin O titres and throat swab culture on all children admitted with Henoch-Schonlein purpura, as well as their matched controls. Antistreptolysin O titre positivity was associated with a 10-fold increase in the risk of Henoch-Schonlein purpura. Renal involvement was common among cases with positive antistreptolysin O titres (27%) compared with cases with a negative titre (8%) but this difference has no statistical significance.
al-Sheyyab
M
M
Department of Pediatrics, Jordan University of Science, Irbid, Jordan. sheyyab@nol.com.jo
Batieha
A
A
el-Shanti
H
H
Daoud
A
A
D000293:Adolescent; D000989:Antistreptolysin / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000209:etiology* / Q000382:microbiology; D007223:Infant; D008297:Male; D010614:Pharynx / Q000382:microbiology; D011446:Prospective Studies; D012307:Risk Factors; D013290:Streptococcal Infections / Q000097:blood / Q000150:complications* / Q000382:microbiology; D013297:Streptococcus pyogenes
D000989:Antistreptolysin