title: Socioeconomic status, hostility, and risk factor clustering in the Normative Aging Study: any help from the concept of allostatic load?
abstract: OBJECTIVE
  To examine the relationships between socioeconomic status (SES), psychosocial vulnerability (hostility), and allostatic load. Allostatic load refers to the cumulative physiological cost of adaptation to stress.
  
  
  METHODS
  We examined the relationships between SES (as measured by educational attainment), hostility, and allostatic load in the Normative Aging Study, a longitudinal study of community-dwelling men aged 21 to 80 years and free of known chronic medical conditions at entry in the 1960s. In 1986, the revised Minnesota Multiphasic Personality Inventory was administered by mail, from which a hostility measure was derived by summing the scores from three Cook-Medley subscales: Hostile Affect, Hostile Attribution, Aggressive Responding. An index of allostatic load was constructed from data collected during physical exams conducted between 1987 and 1990 (i.e. measures reflecting "wear and tear" on the cardiovascular, endocrine, and metabolic systems). Cross-sectional relationships between education, hostility, and allostatic load were examined in 818 men.
  
  
  RESULTS
  Separate linear regression analyses indicated that lower levels of educational attainment and greater hostility were both associated with higher allostatic load scores (p < .05 and p < .01, respectively). Less education was also associated with higher hostility (p < .001). When allostatic load was regressed simultaneously on education and hostility, the effect of education was attenuated, while hostility (p < .05) maintained an independent effect.
  
  
  CONCLUSIONS
  Our findings suggest that lower levels of education and greater hostility are associated with greater "wear and tear" on the body. The effects of education on allostatic load may be mediated by hostility.
authors.affiliation: Department of Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115-6096 USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Kubzansky
authors.forename: I
authors.initials: I
authors.lastname: Kawachi
authors.forename: D
authors.initials: D
authors.lastname: Sparrow
mesh_terms: D000222:Adaptation, Physiological; D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology* / Q000523:psychology*; D001786:Blood Glucose; D001794:Blood Pressure; D001824:Body Constitution; D002395:Catecholamines / Q000652:urine; D004522:Educational Status; D005163:Factor Analysis, Statistical; D005500:Follow-Up Studies; D006791:Hostility; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008137:Longitudinal Studies; D008950:MMPI; D008297:Male; D008875:Middle Aged; D012959:Socioeconomic Factors; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D014481:United States
chemical_list: D001786:Blood Glucose; D002395:Catecholamines; D008055:Lipids