Role of acyl-CoA binding protein in acyl-CoA metabolism and acyl-CoA-mediated cell signaling.
Long-chain acyl-CoA esters (LCA) act both as substrates and intermediates in metabolism and as regulators of various intracellular functions. Acyl-CoA binding protein (ACBP) binds LCA with high affinity and is believed to play an important role in intracellular acyl-CoA transport and pool formation and therefore also for the function of LCA as metabolites and regulators of cellular functions . The free concentration of cytosolic LCA is efficiently buffered to low nanomole concentration by ACBP and fatty acid binding protein (FABP). An additional important factor is the activity of acyl-CoA hydrolases. The estimated cellular free LCA concentration is two to four orders of magnitude lower than the concentrations reported to be necessary to regulate most LCA-affected cellular functions. Preliminary evidence indicates that the regulatory effect of LCA might be mediated by the LCA/ACBP complex.
Knudsen
J
J
Institute of Biochemistry, Odense University, Denmark.
Neergaard
T B
TB
Gaigg
B
B
Jensen
M V
MV
Hansen
J K
JK
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology / Q000502:physiology*; D026261:Diazepam Binding Inhibitor; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D006801:Humans; D011485:Protein Binding; D015398:Signal Transduction / Q000187:drug effects
D000214:Acyl Coenzyme A; D002352:Carrier Proteins; D026261:Diazepam Binding Inhibitor