title: Use of the forced oscillation technique to assess airway obstruction and reversibility in children.
abstract: The forced oscillation technique (FOT) is particularly attractive in a pediatric setting as it requires only passive cooperation from the child. We assessed the sensitivity and specificity of this method for detecting airway obstruction and its reversibility in 313 children (3 to 16 yr of age) with asthma or chronic nocturnal cough. Baseline and post-bronchodilator (n = 251) resistance were measured (R(0)) with the FOT. Baseline R(0) was normalized for height and weight [R(0)(SD)]. In children able to perform forced expiratory maneuvers (n = 181), R(0)(SD) was independently correlated with FEV(1) (p < 0.02) and maximal expiratory flow at 50% (MEF(50)) (p < 0.004). The optimal R(0)(SD) cutoff value given by receiver operating characteristic (ROC) curves to discriminate between children with baseline FEV(1) < 80% or >/= 80% of predicted values yielded 84% sensitivity and 73% specificity. Post-bronchodilator changes in R(0)(SD) [DeltaR(0)(SD)] were mostly correlated to changes in MEF(50). The optimal DeltaR(0)(SD) cutoff value to discriminate between children with the presence or absence of significant reversibility in FEV(1) yielded 69% sensitivity and 78% specificity. In children unable to perform forced expiratory maneuvers (n = 132), this DeltaR(0)(SD) cutoff clearly identified a subgroup of young children with high R(0) values at baseline, that returned to normal after bronchodilation. We conclude that FOT measurements allow reliable evaluation of bronchial obstruction and its reversibility in asthmatic children over 3 yr old.
authors.affiliation: Service de Pédiatrie and Service de Pneumologie, Centre Hospitalier Intercommunal de Créteil, Créteil, France. delacour@im3.inserm.fr
authors.forename: C
authors.initials: C
authors.lastname: Delacourt
authors.forename: H
authors.initials: H
authors.lastname: Lorino
authors.forename: M
authors.initials: M
authors.lastname: Herve-Guillot
authors.forename: P
authors.initials: P
authors.lastname: Reinert
authors.forename: A
authors.initials: A
authors.lastname: Harf
authors.forename: B
authors.initials: B
authors.lastname: Housset
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology*; D000420:Albuterol / Q000008:administration & dosage*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D009991:Oscillometry; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects / Q000502:physiology
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol