Effect of a phosphorylated guar gum hydrolysate on increased calcium solubilization and the promotion of calcium absorption in rats.
The effect of a phosphorylated guar gum hydrolysate (P-GGH) on calcium solubilization and its influence on calcium absorption were studied in vitro and in vivo. P-GGH was prepared by chemically modifying a guar gum hydrolysate (GGH) with sodium metaphosphate. P-GGH inhibited the precipitation of calcium phosphate in vitro. The apparent calcium absorption and the amount of femur calcium were significantly higher in rats fed on the P-GGH diet (50 g/kg of diet) than in rats fed on the GGH diet (50 g/kg of diet) or the control diet. Moreover, the amount of soluble calcium in the ileal contents was significantly higher in the P-GGH-fed rats than in the GGH-fed rats. These results indicate that P-GGH may inhibit calcium phosphate formation in the lower part of the small intestine, and thus increase calcium absorption.
Watanabe
O
O
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan. watanabe@foodhokkaido.gr.jp
Hara
H
H
Kasai
T
T
D000818:Animals; D002118:Calcium / Q000493:pharmacokinetics*; D004043:Dietary Fiber / Q000494:pharmacology*; D005685:Galactans / Q000494:pharmacology*; D006868:Hydrolysis; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008351:Mannans / Q000494:pharmacology*; D010766:Phosphorylation; D053149:Plant Gums; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility
D004043:Dietary Fiber; D005685:Galactans; D008351:Mannans; D053149:Plant Gums; C007894:guar gum; D002118:Calcium