Acute encephalopathy due to aluminum toxicity successfully treated by combined intravenous deferoxamine and hemodialysis.
Acute aluminum intoxication is uncommon in clinical practice but can be fatal. This limited experience is reflected in the paucity of data assessing a viable approach to the treatment of these patients. In this report, the authors describe the clinical course and successful, pharmacokinetic-based deferoxamine-hemodialysis treatment regimen of a patient with severe aluminum encephalopathy following alum bladder irrigation. The combined use of deferoxamine and appropriately timed hemodialysis appears to be a very reasonable means of treating patients with severe acute aluminum intoxication.
Nakamura
H
H
Division of Pediatric Pharmacology and Critical Care, Rainbow Babies and Children's Hospital, Cleveland, OH 44106-6010, USA.
Rose
P G
PG
Blumer
J L
JL
Reed
M D
MD
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000534:Alum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D003676:Deferoxamine / Q000008:administration & dosage / Q000627:therapeutic use*; D003693:Delirium / Q000139:chemically induced / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D006435:Renal Dialysis
D000534:Alum Compounds; C041524:aluminum sulfate; D003676:Deferoxamine