1-octanol/water distribution coefficient of oxolinic acid: influence of pH and its relation to the interaction with dissolved organic carbon.
The distribution of oxolinic acid (OA) between 1-octanol and buffers at a broad range of pH values was studied and found to decrease with increasing pH. The distribution coefficient to dissolved organic carbon (DOC), log DDOC, was estimated and compared with an experimentally derived log DDOC, showing the experimental value to be almost three orders of magnitude higher. Because only the neutral molecule is assumed to distribute to 1-octanol, the interaction with DOC is considered to be electrostatic in character.
Lützhøft
H C
HC
Department of Analytical and Pharmaceutical Chemistry, Royal Danish School of Pharmacy, Copenhagen O, Denmark. hchl@mail.dfh.dk
Vaes
W H
WH
Freidig
A P
AP
Halling-Sørensen
B
B
Hermens
J L
JL
D020003:1-Octanol / Q000737:chemistry* / Q000378:metabolism; D002138:Calibration; D002244:Carbon / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D010093:Oxolinic Acid / Q000737:chemistry* / Q000378:metabolism
D002244:Carbon; D010093:Oxolinic Acid; D020003:1-Octanol