title: Pathogenicity of a new neurotropic equine herpesvirus 9 (gazelle herpesvirus 1) in horses.
abstract: Pathogenicity of equine herpesvirus 9 (EHV-9), a new type of equine herpesvirus isolated from Gazella thomsoni, in horses was investigated by intranasal inoculation of EHV-9 (10(7) pfu) to two conventionally reared 8-months old half-bred weanling horses. Fever higher than 39 degrees C was recorded. Virus was recovered from nasal swabs and peripheral blood mononuclear cells. Both horses developed neutralizing antibody to EHV-9. Perivascular infiltration of mononuclear cells and glial reaction were found in the olfactory and limbic systems. The results suggested that EHV-9 has a pathogenicity in horses.
authors.affiliation: Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Fukushi
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.forename: T
authors.initials: T
authors.lastname: Masegi
authors.forename: K
authors.initials: K
authors.lastname: Hirai
mesh_terms: D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000473:pathology / Q000821:virology; D002460:Cell Line; D004285:Dogs; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D006734:Horse Diseases / Q000473:pathology / Q000821:virology*; D006736:Horses; D008168:Lung / Q000473:pathology / Q000821:virology; D009500:Neutralization Tests / Q000662:veterinary; D018140:Varicellovirus / Q000472:pathogenicity*; D017201:Virus Shedding