Evolution of the human genome under selective pressure from malaria: applications for control.
Research on the molecular basis for resistance of humans to malaria has been vigorous during the last 10 years, with new discoveries and extension of work from previous decades. Much of the work has important implications both for understanding pathogenesis and for applications for control of disease.
Miller
L H
LH
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. lmiller@niaid.nih.gov
D000818:Animals; D019143:Evolution, Molecular; D006453:Hemoglobinopathies / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D008288:Malaria / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D012641:Selection, Genetic