title: Clinical features and treatment of Malassezia folliculitis with fluconazole in orthotopic heart transplant recipients.
abstract: Orthotopic heart transplant recipients need immunosuppressive treatment and are at an increased risk for opportunistic infections such as Malassezia folliculitis. During a 4-month period (July to October 1990), 11 such cases were identified and treated; all were male with mean age of 43+/-9 years and on standard triple immunosuppressive therapy. Skin scrapings in potassium hydroxide (KOH) preparation with microscopy and/or culture identified either Malassezia furfur or Malassezia pachydermatis as the etiologic agent. A treatment with topical preparation (clotrimazole 1% and selenium sulfide lotion) was effective in 6 patients, whereas the rest received systemic fluconazole treatment with satisfactory outcome; all lesions were resolved within 3 weeks. Fluconazole appears to be an effective agent with excellent therapeutic outcome when administered for 3 weeks.
authors.affiliation: Department of Medicine, Temple University Health Sciences Center, School of Medicine, Philadelphia, Pennsylvania 19140, USA.
authors.forename: S
authors.initials: S
authors.lastname: Rhie
authors.forename: R
authors.initials: R
authors.lastname: Turcios
authors.forename: H
authors.initials: H
authors.lastname: Buckley
authors.forename: B
authors.initials: B
authors.lastname: Suh
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D005499:Folliculitis / Q000188:drug therapy* / Q000382:microbiology*; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D008290:Malassezia; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole