title: Immune and pathophysiological processes in baboons experimentally infected with Ebola virus adapted to guinea pigs.
abstract: The dynamics of pathophysiological and immunological parameters monitored in monkeys Papio hamadryas infected with the guinea pig-adapted Ebola virus strain demonstrated that this viral strain preserved its virulence for monkeys and caused the disease with characteristic features similar to those caused by non-adapted Ebola virus. However, certain previously unknown patterns have been observed: (1) prolongation of the febrile period by two days; (2) extended period was characterized by stability of serum biochemical parameters; (3) marked vacuolization of the neutrophil cytoplasm; (4) appearance of juvenile lymphocytes on day 3 and by the end of the disease; and (5) a considerable increase in the spontaneous mononuclear proliferation (along with a decrease in the mitogen-induced proliferation) during the terminal stage of infection. The severity of pathological coagulation was found to correlate with the activity of serum cytokines IFN-alpha and TNF-alpha: their activities increased about 250- and 100-fold, respectively. There was significant alteration in the activity of natural killer cells, that dropped by the time of animal death.
authors.affiliation: Institute of Molecular Biology, State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Russia.
authors.forename: G M
authors.initials: GM
authors.lastname: Ignatiev
authors.forename: A A
authors.initials: AA
authors.lastname: Dadaeva
authors.forename: S V
authors.initials: SV
authors.lastname: Luchko
authors.forename: A A
authors.initials: AA
authors.lastname: Chepurnov
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001772:Blood Cell Count; D004195:Disease Models, Animal; D029043:Ebolavirus / Q000276:immunology* / Q000472:pathogenicity*; D005260:Female; D006168:Guinea Pigs; D019142:Hemorrhagic Fever, Ebola / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D066298:In Vitro Techniques; D016898:Interferon-alpha / Q000097:blood; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D009504:Neutrophils / Q000473:pathology; D010215:Papio; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014617:Vacuoles / Q000473:pathology; D014774:Virulence
chemical_list: D016898:Interferon-alpha; D014409:Tumor Necrosis Factor-alpha