title: Cerebrospinal fluid protein concentrations in children: age-related values in patients without disorders of the central nervous system.
abstract: BACKGROUND
  The published reference values for cerebrospinal fluid (CSF) total protein concentrations in children suffer from two major drawbacks: (a) the age-related range often is too broad when applied to the steeply falling concentrations in early infancy; and (b) no values have been published for widely used dry chemistry methods.
  
  
  METHODS
  We conducted a 2-year retrospective survey of CSF results obtained in a children's hospital with a dry chemistry-based method set up on the Vitros 700 analyzer.
  
  
  RESULTS
  The data related to ambulatory children up to 16 years of age and term neonates with no clinical or biological signs of brain disease (n = 1074). Seven age groups with significantly different CSF protein values were identified, and their age-related percentiles (5th, 50th, and 95th) were determined. On the basis of the upper 95th percentile, from age 0 to 6 months the CSF protein concentrations fell rapidly from 1.08 to 0.40 g/L. A plateau (0.32 g/L) was reached from age 6 months to 10 years, followed by a slight increase (0.41 g/L) in the 10-16 years age range.
  
  
  CONCLUSIONS
  These results imply that CSF total protein concentrations in the pediatric setting, particularly in infants, must always be interpreted with regard to narrow age-related reference values to avoid false-positive results.
authors.affiliation: Service de Biochemie-Hormonologie, Hôpital Pèdiatrique Robert Debré, Paris, France. daniel.adrbp@wanadoo.fr
authors.forename: D
authors.initials: D
authors.lastname: Biou
authors.forename: J F
authors.initials: JF
authors.lastname: Benoist
authors.forename: C
authors.initials: C
authors.lastname: Nguyen-Thi
authors.forename: X
authors.initials: X
authors.lastname: Huong
authors.forename: P
authors.initials: P
authors.lastname: Morel
authors.forename: M
authors.initials: M
authors.lastname: Marchand
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012016:Reference Values; D012189:Retrospective Studies
chemical_list: D002556:Cerebrospinal Fluid Proteins