Rhenium-188-Labeled DTPA: a new radiopharmaceutical for intravascular radiation therapy.
Balloon angioplasty is a standard treatment for artherosclerotic coronary artery disease. However, its clinical value is reduced by a high restenosis rate. A new concept in preventing restenosis is the use of a liquid-filled balloon containing a beta-emitting radioisotope. In this study, we performed biodistribution studies of Re-188 perrhenate and Re-188 diethylenetriaminopentaacetate (DTPA) to assess the resulting organ dose values in the event of balloon rupture if these agents are used for the clinical inhibition of restenosis after percutaneous transluminal coronary angioplasty (PTCA). After injecting Re-188 preparations intravenously, rats were killed at 10 min, 30 min, 60 min, 2 h, and 6 h (n = 5 per group). Tissue concentrations were calculated and expressed as percent injected dose per gram or per milliliter (%ID/g or %ID/mL). In addition, urine excretion and thyroid gland uptake were evaluated in rats (n = 5 per group) with a gamma camera after administration of 37 MBq (1 mCi) of each agent. Our data showed that both agents were excreted primarily via urine. However, the excretion of Re-188 DTPA was much faster than that of Re-188 perrhenate via the urinary system. The biodistribution data revealed that radioactivity levels in the stomach and the thyroid gland were high in the perrhenate group but low in the Re-188 DTPA group. The concentration levels in other tissues including lung, liver, testis, muscle, and blood were low throughout this study for both agents. The thyroid radiation value in the Re-188 perrhenate group was 0.163 mGy/MBq, which was much higher than that of the Re-188 DTPA group (0.0167 mGy/MBq). The stomach radiation value was as high as 0.127 mGy/MBq for Re-188 perrhenate, compared with 0.013 mGy/MBq for Re-188 DTPA. In conclusion, in the event of balloon rupture, the release of Re-188 DTPA results in lower radiation doses than Re-188 perrhenate, especially to the thyroid gland and the stomach. Our data suggest that Re-188 DTPA is a useful radiopharmaceutical for endovascular irradiation.
Hsieh
B T
BT
Institute of Nuclear Energy Research, Lung-Tan, Taiwan.
Hsieh
J F
JF
Tsai
S C
SC
Lin
W Y
WY
Huang
H T
HT
Ting
G
G
Wang
S J
SJ
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D008297:Male; D004369:Pentetic Acid / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000652:urine; D011868:Radioisotopes; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use* / Q000652:urine; D011878:Radiotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012211:Rhenium / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000652:urine; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000378:metabolism; D014018:Tissue Distribution
D011868:Radioisotopes; D019275:Radiopharmaceuticals; C015428:perrhenate; D012211:Rhenium; D004369:Pentetic Acid