Effects of potassium citrate/citric acid intake in a mouse model of polycystic kidney disease.
The kidney function in a model of autosomal dominant polycystic kidney disease (PKD), the Han:SPRD rat, is dramatically improved by chronic ingestion of a solution of potassium citrate and citric acid (KCitr). This study investigated whether this treatment would also be beneficial in the pcy/pcy mouse, a model of autosomal recessive PKD. Starting at 1 month of age, male CD-1 pcy/pcy and normal CD-1 mice were provided with a solution of 55 mM K(3) citrate/67 mM citric acid or tap water to drink. The pcy/pcy mice on the KCitr solution failed to grow normally and showed elevated plasma urea levels when compared to water-drinking littermates. Growth of normal CD-1 mice was not affected by KCitr intake. The pcy/pcy mice were then provided with a more dilute solution of KCitr to drink: this resulted in greater kidney wet and dry weights and a higher kidney weight/body weight ratio, but no beneficial effects. We conclude that pcy/pcy mice cannot tolerate a high level of KCitr intake and that a lower level is of no benefit. Whether KCitr therapy would be helpful in patients with PKD is still an open question.
Tanner
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GA
Department of Physiology and Biophysics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. gtanner@iupui.edu
Vijayalakshmi
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K
Tanner
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JA
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002614:Chelating Agents / Q000627:therapeutic use*; D019343:Citric Acid / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D017044:Polycystic Kidney, Autosomal Recessive / Q000097:blood / Q000188:drug therapy*; D019357:Potassium Citrate / Q000627:therapeutic use*; D014508:Urea / Q000097:blood
D002614:Chelating Agents; D004232:Diuretics; D019343:Citric Acid; D014508:Urea; D019357:Potassium Citrate