Quantitative determination of dimethicone in commercial tablets and capsules by Fourier transform infrared spectroscopy and antifoaming activity test.
Fourier transform infrared (FTIR) spectroscopy and antifoaming activity test have been employed for the quantitative analysis of dimethicone. Linearity, accuracy and precision are presented for both methods. These methods have been also used to compare different dimethicone-containing proprietary medicines. FTIR spectroscopy has shown to be adequate for quantitation of dimethicone in commercial tablets and capsules in order to comply with USP requirements. The antifoaming activity test is able to detect incompatibilities between dimethicone and other constituents. The presence of certain enzymes in some medicinal products increases the defoaming properties of these formulations.
Torrado
G
G
Department of Pharmaceutical Technology, Faculty of Pharmacy, Alcalá de Henares University, Madrid, Spain.
García-Arieta
A
A
de los Ríos
F
F
Menéndez
J C
JC
Torrado
S
S
D000934:Antifoaming Agents / Q000737:chemistry*; D002214:Capsules; D015203:Reproducibility of Results; D012841:Simethicone / Q000032:analysis*; D013010:Sonication; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
D000934:Antifoaming Agents; D002214:Capsules; D013607:Tablets; D012841:Simethicone