Vagus nerve stimulation therapy for epilepsy in older adults.
The authors assessed the efficacy, safety, and tolerability of vagus nerve stimulation (VNS) for refractory epilepsy in 45 adults 50 years of age and older. They determined seizure frequency, adverse effects, and quality of life. At 3 months, 12 patients had a >50% decrease in seizure frequency; at 1 year, 21 of 31 studied individuals had a >50% seizure decrease. Side effects were mild and transient. Quality of life scores improved significantly with time.
Sirven
J I
JI
Mayo Clinic, Scottsdale, AZ 85259, USA. Sirven.Joseph@mayo.edu
Sperling
M
M
Naritoku
D
D
Schachter
S
S
Labar
D
D
Holmes
M
M
Wilensky
A
A
Cibula
J
J
Labiner
D M
DM
Bergen
D
D
Ristanovic
R
R
Harvey
J
J
Dasheiff
R
R
Morris
G L
GL
O'Donovan
C A
CA
Ojemann
L
L
Scales
D
D
Nadkarni
M
M
Richards
B
B
Sanchez
J D
JD
D004558:Electric Stimulation; D004827:Epilepsy / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014630:Vagus Nerve / Q000503:physiopathology*