title: Carcinosarcoma of the uterus associated with a nongestational choriocarcinoma.
abstract: Choriocarcinoma has been reported in association with endometrial carcinoma and as a metaplastic change in multiple carcinomas, including liver, urinary bladder, lung, and the gastrointestinal tract. We report choriocarcinoma in conjunction with a carcinosarcoma (also called malignant müllerian mixed tumor) in a 71-year-old woman whose hysterectomy specimen revealed two polypoid lesions of the endometrium, one arising from the anterior endometrium and one arising from the posterior endometrium. Histologic examination revealed three histologic patterns. The anterior endometrial lesion showed a FIGO grade 2 endometrioid endometrial adenocarcinoma. The posterior endometrial lesion showed a carcinosarcoma composed of a high-grade adenocarcinoma and scant homologous stromal sarcoma. In addition, a choriocarcinoma was identified intermixed with the adenocarcinoma. The syncytiocytotrophoblasts and cytotrophoblasts stained strongly with 0 human chorionic gonadotropin (beta-hCG) and human placental lactogen (hPL). The patient's beta-hCG levels on postoperative days 14, 27, and 42 were 283, 32, and 7 mIU/mL, respectively. This unusual case suggests the importance of identifying the choriocarcinomatous component, since the serum beta-hCG can serve as a marker of tumor recurrence postoperatively.
authors.affiliation: Department of Pathology, University of Alabama at Birmingham, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Khuu
authors.forename: C P
authors.initials: CP
authors.lastname: Crisco
authors.forename: L
authors.initials: L
authors.lastname: Kilgore
authors.forename: W H
authors.initials: WH
authors.lastname: Rodgers
authors.forename: M G
authors.initials: MG
authors.lastname: Conner
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000302:isolation & purification; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000473:pathology*; D002296:Carcinosarcoma / Q000150:complications / Q000473:pathology*; D002822:Choriocarcinoma / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D018200:Mixed Tumor, Mullerian / Q000150:complications / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology*; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000150:complications* / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D018997:Chorionic Gonadotropin, beta Subunit, Human