title: Diagnosis and treatment of intravascular lymphomatosis.
abstract: OBJECTIVE
  To describe a patient with unusually good outcome of a rare, high-grade lymphoma that often involves the nervous system.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A 70-year-old pharmacist first presented with meningoencephalitislike symptoms and 6 months later with acute confusional state followed by complex partial status epilepticus. Diagnosis of intravascular lymphomatosis was made using detection and biopsy of a bilateral adrenal tumor.
  
  
  RESULTS
  Polychemotherapy consisting of CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone) led to complete remission. The patient's survival time currently exceeds 21/2 years.
  
  
  CONCLUSIONS
  The possibility of intravascular lymphomatosis should be considered in adult patients with unclear meningoencephalitic syndrome, acute confusional state, dementia, or other unexplained neurologic conditions with signs of a systemic disease. In intravascular lymphomatosis, as in other high-grade non-Hodgkin lymphomas, CHOP polychemotherapy should be the standard treatment.
authors.affiliation: Department of Neurology, University Hospital, Basel, Switzerland.
authors.forename: T P
authors.initials: TP
authors.lastname: Baumann
authors.forename: N
authors.initials: N
authors.lastname: Hurwitz
authors.forename: E
authors.initials: E
authors.lastname: Karamitopolou-Diamantis
authors.forename: A
authors.initials: A
authors.lastname: Probst
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
authors.forename: A J
authors.initials: AJ
authors.lastname: Steck
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone