Efficient multigram synthesis of the bifunctional chelating agent (S)-1-p-isothiocyanatobenzyl-diethylenetriaminepentaacetic acid [correction of diethylenetetraminepentaacetic acid].
We have developed and optimized the synthesis of the title compound, eliminating all HPLC purifications prior to the final product. The yield (and scale) of the synthesis was increased from 19% (200 mg) to 75% (26 g).
Corson
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Department of Chemistry, University of California Davis, One Shields Avenue, Davis, California 95616-5295, USA.
Meares
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D000911:Antibodies, Monoclonal / Q000737:chemistry; D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004337:Drug Carriers / Q000138:chemical synthesis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D012997:Solvents
D000911:Antibodies, Monoclonal; D002614:Chelating Agents; D004337:Drug Carriers; D012997:Solvents; C054343:1-(4-isothiocyanatobenzyl)diethylenetriaminepentaacetic acid; D004369:Pentetic Acid