Central nervous system (CNS) tuberculosis following allogeneic stem cell transplantation.
Tuberculosis is an uncommon infectious complication after stem cell transplantation. We report a patient who presented with a brain mass, 3 months after pulmonary tuberculosis had been diagnosed and while he was receiving triple antituberculous therapy. He had extensive chronic GVHD. The diagnosis was made after biopsy of the lesion. The cerebral mass was excised, antituberculous treatment was maintained and the patient made a complete neurologic recovery. Six months later, he died of gram-negative septic shock. Mycobacterial infections should be considered in allograft recipients with chronic GVHD and solid lesions in the brain. Bone Marrow Transplantation (2000) 25, 567-569.
Campos
A
A
Bone Marrow Transplant Unit, Instituto Português de Oncologia, Porto, Portugal.
Vaz
C P
CP
Campilho
F
F
Morais
A
A
Guimarães
M A
MA
Lopes
C
C
Portal
A
A
Carvalhais
A
A
Pimentel
P
P
D001921:Brain / Q000473:pathology / Q000601:surgery; D002494:Central Nervous System Infections / Q000209:etiology / Q000382:microbiology / Q000628:therapy; D006086:Graft vs Host Disease / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012772:Shock, Septic / Q000209:etiology; D014184:Transplantation, Homologous / Q000009:adverse effects; D020306:Tuberculosis, Central Nervous System / Q000209:etiology* / Q000628:therapy; D014397:Tuberculosis, Pulmonary / Q000139:chemically induced / Q000150:complications