title: Phages will out: strategies of host cell lysis.
abstract: Most phages accomplish host lysis using a muralytic enzyme, or endolysin, and a holin, which permeabilizes the membrane at a programmed time and thus controls the length of the vegetative cycle. By contrast, lytic single-stranded RNA and DNA phages accomplish lysis by producing a single lysis protein without muralytic activity.
authors.affiliation: Dept of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128, USA. ryland@tamu.edu
authors.forename: I
authors.initials: I
authors.lastname: Young
authors.forename: I
authors.initials: I
authors.lastname: Wang
authors.forename: W D
authors.initials: WD
authors.lastname: Roof
mesh_terms: D000595:Amino Acid Sequence; D001435:Bacteriophages / Q000378:metabolism* / Q000472:pathogenicity; D002463:Cell Membrane Permeability; D010450:Endopeptidases / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000821:virology; D008565:Membrane Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; C108624:S holin, bacteriophage lambda; D014764:Viral Proteins; C082268:Rz protein, bacteriophage lambda; D010450:Endopeptidases; C001143:endolysin