Comparison of pivmecillinam and cephalexin in acute uncomplicated urinary tract infection.
The clinical and bacteriological efficacy of a 3-day course of pivmecillinam, 200 mg three times daily, was compared with that of a 7-day course of cephalexin, 250 mg four times daily, in 216 patients with a bacteriologically confirmed, acute, uncomplicated, urinary tract infection. Both treatments were similarly effective. Clinical cure or improvement was obtained in 95.3% of patients given pivmecillinam and in 93.6% of patients given cephalexin. Bacteriological success was achieved in 89.7 and 81.7% patients taking pivmecillinam or cephalexin, respectively. Eradication rates for Escherichia coli were 90.1% for pivmecillinam and 80.6% for cephalexin. Both treatments were well tolerated. This study has confirmed that a 3-day course of pivmecillinam is effective and well tolerated in uncomplicated cystitis.
Menday
A P
AP
Leo Pharmaceuticals, Princes Risborough, Bucks, UK. paul.menday@leo-pharma.com
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000561:Amdinocillin Pivoxil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D002506:Cephalexin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003556:Cystitis / Q000188:drug therapy / Q000382:microbiology; D004311:Double-Blind Method; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D005483:Flushing / Q000139:chemically induced; D019584:Hot Flashes / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000561:Amdinocillin Pivoxil; D002506:Cephalexin