Aqueous humour levels of topically applied ciprofloxacin and ofloxacin in the same subjects.
OBJECTIVE
To evaluate aqueous humour levels of topical 0.3% ciprofloxacin and 0.3% ofloxacin in the same subjects.


METHODS
Thirty-two bilateral cataractous patients received topical 0.3% ciprofloxacin in one eye and 0.3% ofloxacin in the other eye before each cataract extraction. Eyedrops were repetitively instilled for 6 h. Aqueous humour samples were collected and assayed for drug concentrations by a method described originally by us using high-performance liquid chromatography.


RESULTS
Mean aqueous ciprofloxacin and ofloxacin levels were 0.33 +/- 0.04 microgram/ml (mean +/- SEM) and 1.34 +/- 0.14 micrograms/ml respectively (p < 0.0001).


CONCLUSIONS
Ofloxacin level in the aqueous humour is 4 times higher than that of ciprofloxacin in the same subjects.
Cekiç
O
O
Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Batman
C
C
Totan
Y
Y
Yasar
U
U
Basci
N E
NE
Bozkurt
A
A
Kayaalp
S O
SO
Zilelioglu
O
O
D000287:Administration, Topical; D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D019072:Antibiotic Prophylaxis / Q000379:methods; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000493:pharmacokinetics*; D009883:Ophthalmic Solutions
D000890:Anti-Infective Agents; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin; D015242:Ofloxacin