title: Potential use of radiolabeled antisense oligonucleotides in oncology.
abstract: Antisense oligodeoxynucleotides (ODNs) have great promise for therapy. Oligomers labeled with gamma-emitting radioelements have great promise for diagnosis. These radiolabeled oligomers can be used to identify the presence of a particular messenger RNA through simple external detection of radioactivity by means of scintigraphy. This review evaluates the progress in the development of antisense oligodeoxynucleotides for non-invasive imaging of chemoresistance. As nominated by H.N. Wagner at the final session of Nuclear Medicine congress in Denver, the deoxyribonucleic acid is "the molecule of the millennium".
authors.affiliation: Laboratoire d'Etude des Radiopharmaceutiques, ESA CNRS 5077, Université J. Fourier, Grenoble, France.
authors.forename: A S
authors.initials: AS
authors.lastname: Gauchez
authors.forename: A
authors.initials: A
authors.lastname: Du Moulinet D'Hardemare
authors.forename: J
authors.initials: J
authors.lastname: Lunardi
authors.forename: J P
authors.initials: JP
authors.lastname: Vuillez
authors.forename: D
authors.initials: D
authors.lastname: Fagret
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D016376:Oligonucleotides, Antisense / Q000737:chemistry / Q000627:therapeutic use*; D011868:Radioisotopes / Q000737:chemistry*
chemical_list: D016376:Oligonucleotides, Antisense; D011868:Radioisotopes