title: The effect of dexamethasone pretreatment on chlordiazepoxide and oxazepam levels in rat plasma.
abstract: The effect of dexamethasone pretreatment on the level of chlordiazepoxide and oxazepam was examined in the plasma of rats administered with 80 mg/kg of chlorodiazepoxide per os. The concentration of free chlordiazepoxide and unconjugated oxazepam was determined by HPLC method after solid-phase extraction. Pretreatment with dexamethasone significantly increased chlordiazepoxide plasma level 3, 6 and 12 hrs after ingestion, however increase of oxazepam concentration was not statistically significant. AUC 1-24 h after dexamethasone was elevated, for chlordiazepoxide and for oxazepam.
authors.affiliation: Department of Toxicology, Warsaw Medical University, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Osicka-Koprowska
authors.forename: R
authors.initials: R
authors.lastname: Wasilewska
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000097:blood*; D002707:Chlordiazepoxide / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003907:Dexamethasone / Q000494:pharmacology*; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D010076:Oxazepam / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
chemical_list: D014151:Anti-Anxiety Agents; D005938:Glucocorticoids; D010076:Oxazepam; D002707:Chlordiazepoxide; D003907:Dexamethasone