In vivo and in vitro immunomodulatory activities of Trichilia glabra aqueous leaf extracts.
The effects of Trichilia glabra (Meliaceae) aqueous leaf extract on mouse lymphocytes were studied. The in vitro proliferation of T and B lymphocytes was completely impaired. Besides, the extract significantly diminished both antibody and delayed hypersensitivity responses in treated mice. These results suggest that the extract exerts a marked immunomodulatory effect on the murine immune system.
Benencia
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F
Dpto. Química Biológica, Facultad de Ciencias Exactas y Naturales, Pabellón II, Piso 4, Ciudad Universitaria, Buenos Aires, Argentina. fbenen@qb.fcen.uba.ar
Courrèges
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MC
Coulombié
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FC
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000917:Antibody Formation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005260:Female; D006968:Hypersensitivity, Delayed; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts