title: Cytomegalovirus retinitis in a patient with Wegener's granulomatosis.
abstract: Cytomegalovirus retinitis (CMVR) is a rare complication of systemic immunosuppressive therapy in patients with rheumatic disorders. We describe a 44-year-old man with Wegener's granulomatosis who was treated with cyclophosphamide and methylprednisolone and who subsequently developed bilateral CMVR. In spite of discontinuation of immunosuppressive therapy and administration of systemic ganciclovir, retinitis recurred and maintenance therapy was needed. In conclusion, increased awareness of this potentially serious complication of immunosuppressive therapy is critical. If immune recovery is slow after discontinuation of immunosuppressive agents, prolonged antiviral therapy is required in order to prevent recurrences of CMVR.
authors.affiliation: Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey. tutkun@turk.net
authors.forename: I
authors.initials: I
authors.lastname: Tugal-Tutkun
authors.forename: N
authors.initials: N
authors.lastname: Kir
authors.forename: A
authors.initials: A
authors.lastname: Gül
authors.forename: M
authors.initials: M
authors.lastname: Koniçe
authors.forename: M
authors.initials: M
authors.lastname: Urgancioglu
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D015774:Ganciclovir / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D012008:Recurrence; D014792:Visual Acuity
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D015774:Ganciclovir; D008775:Methylprednisolone