Are neurological abnormalities in schizophrenic patients and their siblings the result of perinatal trauma?
OBJECTIVE
Previous findings of increased neurological abnormalities in schizophrenic patients and their non-psychotic siblings raise the question of possible causes. The purpose of the present study was to examine the role of perinatal trauma in the aetiology of neurological abnormality.


METHODS
Obstetric information obtained from hospital records for 55 schizophrenic patients and 19 non-psychotic siblings was scored blindly and separately from a neurological assessment of hard and soft signs.


RESULTS
Obstetric complications (OCs) were significantly increased in patients but not in siblings compared to their respective neonatal control groups. Neurological abnormalities were related to OCs in siblings but not in patients. Neurological abnormalities in patients were negatively related to reduced neonatal head circumference.


CONCLUSIONS
Early somatic trauma may increase the probability of neurological abnormality in individuals who are genetically 'at risk'.
Cantor-Graae
E
E
Department of Community Medicine, Lund University, University Hospital, Malmö, Sweden.
Ismail
B
B
McNeil
T F
TF
D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D005260:Female; D006257:Head / Q000002:abnormalities*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D007744:Obstetric Labor Complications; D010554:Personality Disorders / Q000175:diagnosis; D011247:Pregnancy; D011569:Psychiatric Status Rating Scales; D011897:Random Allocation; D012559:Schizophrenia / Q000175:diagnosis / Q000209:etiology*; D012801:Sibling Relations