[Concentration of macroergic phosphates and oxidative potential of skeletal muscles].
It is known that a long-duration decline of high-energy phosphate (HP) level in skeletal muscles, induced by administration of beta-guanidinpropionic acid (beta-GPA), is followed by an increase in mitochondrial enzyme activities (MEA). The same increase in MEA was observed in the course of physical exercise training. Under gravitational inloading decrease in MEA and increase in the level of high-energy phosphates occurred. If changes in (HP) level are believed to trigger the alterations in MEA, the increase in high-energy phosphate levels in muscles is to lead to a decline in MEA as well. The present work was purposed to reveal if changes in HP level under different contractile activity levels may be associated with changes in oxidative potential in the skeletal muscles.
Nemirovskaia
T L
TL
Faculty of Basic Medicine, Moscow State University.
Shenkman
B S
BS
Mazin
M G
MG
Koshelev
V B
VB
Maevskiĭ
E I
EI
Grishina
E
E
D000818:Animals; D003401:Creatine / Q000008:administration & dosage; D004579:Electron Transport; D006146:Guanidines / Q000008:administration & dosage; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism*; D010084:Oxidation-Reduction; D010710:Phosphates / Q000378:metabolism*; D011422:Propionates / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar
D006146:Guanidines; D010710:Phosphates; D011422:Propionates; D003401:Creatine; C005775:guanidinopropionic acid