Nonreceptor interactions in the pharmacology of blood platelets.
On the basis of values corresponding to concentrations exhibiting 50% inhibition of platelet aggregation induced with different stimuli and 50% inhibition of arachidonic acid liberation and thromboxane generation, we compared the antiplatelet effect of two cationic amphiphilic drugs--chloroquine and dithiaden. Compared to chloroquine, dithiaden was much more effective in inhibiting platelet aggregation, A-23187 induced arachidonic acid liberation and thromboxane generation. Chloroquine, on the other hand, was more effective in the inhibition of thrombin-induced arachidonic acid liberation.
Nosál
R
R
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava. exfarano@savba.sk
Jancinová
V
V
D000328:Adult; D016718:Arachidonic Acid / Q000097:blood; D001582:Benzothiepins / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D000001:Calcimycin / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology; D013929:Thromboxane B2 / Q000097:blood
D001582:Benzothiepins; D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D000001:Calcimycin; D013929:Thromboxane B2; C100170:dithiadene; D002738:Chloroquine; D010741:Phospholipases A; D013917:Thrombin