title: Repeated 131I treatment of a residual ovarian teratoma containing malignant thyroid tissue.
abstract: A 49-year-old woman with ovarian teratoma received 131I treatment three times for an unresectable mass containing malignant thyroid tissue after surgery. Repeated 131I treatment effectively reduced serum thyroglobulin (Tg) level and tumour uptake of 131I, despite absence of any change in size of the treated tumour. Treatment did not inhibit the increase of serum CA-125 and tumour 201Tl uptake, associated with progression of a radioresistant intratumoral hyper-perfused tissue component, detected by colour Doppler ultrasound. Serum CA-125 level and tumour 201Tl uptake were not significantly changed despite temporary increases in serum Tg level after each 131I treatment. These observations indicate the importance of diagnostic measures using combined functional imaging and tumour markers in managing this rare tumour.
authors.affiliation: Department of Radiology, Yamaguchi University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Suga
authors.forename: A
authors.initials: A
authors.lastname: Hirabayashi
authors.forename: K
authors.initials: K
authors.lastname: Motoyama
authors.forename: N
authors.initials: N
authors.lastname: Kume
authors.forename: N
authors.initials: N
authors.lastname: Matsunaga
authors.forename: H
authors.initials: H
authors.lastname: Tamura
authors.forename: H
authors.initials: H
authors.lastname: Kato
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood; D002828:Choristoma / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008875:Middle Aged; D018365:Neoplasm, Residual; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D019233:Retreatment; D013724:Teratoma / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D013961:Thyroid Gland; D013964:Thyroid Neoplasms / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D013972:Thyrotropin / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D018615:Ultrasonography, Doppler, Color
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D014284:Triiodothyronine; D013972:Thyrotropin