False-positive pregnancy test associated with gonadoblastoma.
Gonadoblastomas are known to be hormonally active tumors that occur in streak or dysgenetic gonads of patients with intersex abnormalities. Several reports document their ability to produce beta-human chorionic gonadotropin (HCG), but none have documented an elevated peripheral serum beta-HCG. We report on the case of a patient with pure gonadal dysgenesis with XY karyotype who was found to have an elevated peripheral serum beta-HCG after a positive pregnancy test. Knowledge of gonadoblastoma's potential to elevate serum beta-HCG levels may prevent unnecessary searches for other causes.
Schanne
F J
FJ
Division of Pediatric Urology, Children's Hospital of Philadelphia, PA, 19104 USA.
Cooper
C S
CS
Canning
D A
DA
D000293:Adolescent; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005189:False Positive Reactions; D005260:Female; D006061:Gonadal Dysgenesis, 46,XY / Q000097:blood / Q000150:complications*; D018238:Gonadoblastoma / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D011258:Pregnancy Tests
D018997:Chorionic Gonadotropin, beta Subunit, Human