title: Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas.
abstract: Tumour necrosis factor alpha (TNF-alpha) appears important in ultraviolet-induced immunosuppression, suggesting that it is a susceptibility candidate for cutaneous basal cell carcinoma (BCC). We now describe data on the association between TNF microsatellite polymorphisms, first on susceptibility in 202 controls and 133 cases each having two to 30 BCCs, and secondly, within the cases, on BCC numbers. The data show that the proportions of individuals with TNF a1- and a7-containing genotypes were significantly different (P = 0. 0271, P = 0.0393, respectively) between cases and controls. Secondly, within the cases, TNF alleles d4 (P = 0.023) and d6 (P = 0.006) alone, and the TNF a2-b4-d5 haplotype (P = 0.007), were significantly associated with the number of BCC lesions. These preliminary data provide the first evidence that TNF microsatellite polymorphism may influence the pathogenesis of multiple BCC.
authors.affiliation: ARC Epidemiology Research Unit, Stopford Building, University of Manchester, Manchester, U.K.
authors.forename: A H
authors.initials: AH
authors.lastname: Hajeer
authors.forename: J T
authors.initials: JT
authors.lastname: Lear
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
authors.forename: M
authors.initials: M
authors.lastname: Naves
authors.forename: J
authors.initials: J
authors.lastname: Worthington
authors.forename: D A
authors.initials: DA
authors.lastname: Bell
authors.forename: A G
authors.initials: AG
authors.lastname: Smith
authors.forename: W P
authors.initials: WP
authors.lastname: Bowers
authors.forename: P W
authors.initials: PW
authors.lastname: Jones
authors.forename: R C
authors.initials: RC
authors.lastname: Strange
authors.forename: A A
authors.initials: AA
authors.lastname: Fryer
mesh_terms: D000483:Alleles; D002280:Basal Cell Carcinoma / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics; D012044:Regression Analysis; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha