title: Factors affecting survival for floor-of-mouth carcinoma.
abstract: OBJECTIVE
  The treatment of extensive floor-of-mouth carcinoma has remained a challenging problem for head and neck surgeons. We have reviewed our experience in the surgical management of floor-of-mouth cancer in an attempt to identify factors influencing survival.
  
  
  METHODS
  A total of 144 patients with cancer involving the floor of the mouth were treated between March 1988 and November 1995. A retrospective chart review was conducted that captured information including clinical staging, therapeutic modalities, pathologic findings, and patient follow-up. Factors affecting survival were assessed by nonparametric analysis and analysis of variance.
  
  
  RESULTS
  There was no statistical significance for the effects of vascular invasion (P = 0.4019), lymphatic invasion (P = 0.3430), bone invasion (P = 0.1548), or positive margins (P = 0.1113) on survival. Extranodal extension and recurrent disease were strongly suggestive of influencing survival but were not statistically significant (P = 0.0650 and P = 0.0504, respectively). Nodal disease significantly affected survival (P = 0.0138) but did not affect recurrence (P = 0.451).
  
  
  CONCLUSIONS
  Mean survival for this cohort was 30.6 months. Positive node status significantly affected mean overall survival in this series, whereas extracapsular disease did not. These data suggest that aggressive surgical management of neck disease is mandated to maximize survival.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Klotch
authors.forename: C
authors.initials: C
authors.lastname: Muro-Cacho
authors.forename: T J
authors.initials: TJ
authors.lastname: Gal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality* / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009060:Mouth Floor; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies