title: [Physiology and pathophysiology of erectile dysfunction].
abstract: Erectile dysfunction is an entity associated with age but is not necessarily a consequence of aging. During erection the penis acts as a capacitor--accumulating blood under pressure. Erectile function is, therefore, dependent on the integration and regulation of functional interplay between psychologic, neurologic, endocrine and vasoactive factors. Any imbalance in the integration of these factors will result in erectile dysfunction. Trabecular smooth muscle is an important structure, which contributes to control of detumescence and erection. The smooth muscle tone is mediated by many hormones and vasoactive factors (e.g. norepinephrine, acetylcholine, NO, VIP, prostaglandins etc.) but its functioning is also dependent on a sufficient oxygenation to prevent the fibrosis of this important structure. This oxygenated state is achieved during erections. So we can conclude: Erections are good for erections.
authors.affiliation: Urologischen Abteilung, Landeskrankenanstalten Salzburg. A.Jungwirth@lkasbg.gv.at
authors.forename: A
authors.initials: A
authors.lastname: Jungwirth
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D004594:Electrophysiology; D007172:Erectile Dysfunction / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D008297:Male; D009479:Neuropeptides / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000502:physiology; D010410:Penile Erection / Q000502:physiology*; D010413:Penis / Q000033:anatomy & histology / Q000502:physiology* / Q000503:physiopathology; D012725:Sexual Behavior / Q000502:physiology
chemical_list: D009479:Neuropeptides; D019001:Nitric Oxide Synthase