IC202B and C, new siderophores with immunosuppressive activity produced by Streptoalloteichus sp. 1454-19.
IC202B (1) and C (2) were isolated from the culture filtrate of Streptoalloteichus sp. 1454-19. The structures were elucidated by various NMR spectral analyses including 1H-15N HMBC and FAB-MS experiments. IC202B and C showed immunosuppressive activity on a mixed lymphocyte culture reaction at the same IC50 value of 1.6 microg/ml.
Iijima
M
M
Institute for Chemotherapy, MCRF, Shizuoka, Japan.
Someno
T
T
Ishizuka
M
M
Sawa
R
R
Naganawa
H
H
Takeuchi
T
T
D000192:Actinomycetales / Q000737:chemistry / Q000378:metabolism*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017262:Siderophores / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000577:Amides; D006877:Hydroxamic Acids; C405822:IC 202B; C405823:IC 202C; D007166:Immunosuppressive Agents; D017262:Siderophores