Hemodynamic effect of a low-resistance artificial lung in series with the native lungs of sheep.
BACKGROUND
An artificial lung with 1 to 6 month work life could act as a bridge to transplantation. A pumpless artificial lung has been developed.


METHODS
The artificial lung was placed in series with the native lungs of adult sheep. Hemodynamics were observed, as the right ventricle generated flow through the device. Through a left thoracotomy, two 20-mm grafts were anastomosed in an end-to-side fashion to the pulmonary artery. The grafts were externalized, and directed flow through the chest wall, to the extracorporeal lung. The animals were recovered, weaned from the ventilator, and when standing, flow was diverted through the device.


RESULTS
Five of 7 animals survived 24 hours with 75% to 100% of the cardiac output diverted through the device. All animals were active, with interest in food and water, and able to stand.


CONCLUSIONS
The right ventricle perfused the artificial lung with 75% to 100% of the cardiac output for 24 hours. This device demonstrates the feasibility of a pumpless pulmonary assist device relying on the right ventricle for perfusion.
Lynch
W R
WR
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109, USA.
Montoya
J P
JP
Brant
D O
DO
Schreiner
R J
RJ
Iannettoni
M D
MD
Bartlett
R H
RH
D000818:Animals; D001187:Artificial Organs; D002302:Cardiac Output; D005112:Extracorporeal Circulation; D006439:Hemodynamics; D011652:Pulmonary Circulation; D012756:Sheep