Collagen application for sealing of arterial puncture sites in comparison to pressure dressing: a randomized trial.
One-hundred patients undergoing routine diagnostic or interventional catheterization were randomly assigned to receive either percutaneously applied collagen (group A; n = 50) or conventional pressure dressing (group B; n = 50) for sealing of the femoral artery. Clinical variables were comparable in both groups. The heparin dose was 100 IU/kg in 30 patients and 200 IU/kg in 20 patients of either group. The average compression time was 4.3 minutes in group A and 42.3 minutes in group B (p < 0.001). Bleeding was not observed in group A but was observed in 6/50 patients in group B. The time to ambulation was 6.4 hours (range: 4-12 hours) in group A and 21.6 hours (range: 10-48 hours) in group B (p < 0.001). Hematomas with a diameter of > 6 cm developed in 4/50 patients in group A and in 11/50 patients in group B (p < 0.05). Blood transfusion or surgical interventions were not required and there was no loss of ankle pulses in either group.


CONCLUSIONS
Percutaneously applied collagen reduced compression time and duration of bedrest after diagnostic catheterization and PTCA. Despite earlier ambulation, the incidence of bleeding was lower with collagen than with conventional pressure dressing.
Schräder
R
R
Abt. f. Kardiologie, ZIM, Center of Internal Medicine, Universitätsklinikum, Theodor Stern-Kai 7, D-6000 Frankfurt am Main 70, Federal Republic of Germany.
Steinbacher
S
S
Burger
W
W
Kadel
C
C
Vallbracht
C
C
Kaltenbach
M
M
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001458:Bandages; D006328:Cardiac Catheterization / Q000009:adverse effects*; D003094:Collagen / Q000627:therapeutic use; D004864:Equipment and Supplies; D005260:Female; D005263:Femoral Artery / Q000293:injuries; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016602:Needlestick Injuries / Q000150:complications / Q000628:therapy*; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D011312:Pressure; D016896:Treatment Outcome
D006490:Hemostatics; D003094:Collagen