title: Sub-Tenon's local anaesthesia: the effect of hyaluronidase.
abstract: OBJECTIVE
  A prospective, randomised, double blind study was used to investigate the effect of hyaluronidase on the quality of block achieved with sub-Tenon's local anaesthesia.
  
  
  METHODS
  150 patients scheduled for elective cataract surgery were randomly allocated to either sub-Tenon's block with 3 ml lignocaine 2%/adrenaline 1:200 000 alone or with the addition of 30 IU/ml of hyaluronidase. The blocks were assessed for degree of akinesia and reduction of eyelid movement, and also post-injection and postoperative pain scores.
  
  
  RESULTS
  Akinesia and reduction of eyelid movement measured 10 minutes after injection were significantly better in the group with hyaluronidase added to the anaesthetic solution. Postoperative pain scores were not significantly different between the two groups but the post-injection pain score was greater (marginally significant) in the group with hyaluronidase added.
  
  
  CONCLUSIONS
  The addition of hyaluronidase significantly improves the quality of the motor blockade achieved with sub-Tenon's local anaesthesia, but has no effect on the sensory blockade.
authors.affiliation: Department of Ophthalmology, Royal United Hospital, Bath, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Rowley
authors.forename: J E
authors.initials: JE
authors.lastname: Hale
authors.forename: R D
authors.initials: RD
authors.lastname: Finlay
mesh_terms: D000328:Adult; D000368:Aged; D000772:Anesthesia, Local / Q000379:methods*; D002387:Cataract Extraction; D004311:Double-Blind Method; D005133:Eye Movements / Q000187:drug effects; D005143:Eyelids / Q000187:drug effects; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000517:prevention & control; D011446:Prospective Studies
chemical_list: D006821:Hyaluronoglucosaminidase