Positron emission tomography: radioisotope and radiopharmaceutical production.
A Centre for Positron Emission Tomography (PET) has been operational within the Department of Nuclear Medicine at the Austin & Repatriation Medical Centre (A&RMC) in Melbourne for seven years. PET is a non-invasive imaging technique based on the use of biologically relevant compounds labelled with short-lived positron-emitting radionuclides such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18. The basic facility consists of a medical cyclotron (10 MeV proton & 5 MeV deuteron), six lead-shielded hotcells with associated radiochemistry facilities, radiopharmacy and a whole body PET scanner. A strong radiolabelling development program, including the production of 15O-oxygen, 15O-carbon monoxide, 15O-carbon dioxide, 15O-water, 13N-ammonia, 18F-FDG, 18F-FMISO, 11C-SCH23390 and 11C-flumazenil has been pursued to support an ambitious clinical and research program in neurology, oncology, cardiology and psychiatry.
Tochon-Danguy
H J
HJ
Centre for PET, Austin & Repatriation Medical Centre, Melbourne, Victoria, Australia.
Sachinidis
J I
JI
Egan
G F
GF
Chan
J G
JG
Berlangieri
S U
SU
McKay
W J
WJ
Scott
A M
AM
D015195:Drug Design; D004867:Equipment Design; D005947:Glucose / Q000378:metabolism; D000860:Hypoxia / Q000000981:diagnostic imaging / Q000503:physiopathology; D009422:Nervous System Diseases / Q000000981:diagnostic imaging; D010100:Oxygen / Q000378:metabolism; D011786:Quality Control; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000592:standards; D012039:Regional Blood Flow; D014055:Tomography, Emission-Computed / Q000295:instrumentation* / Q000379:methods
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D005947:Glucose; D010100:Oxygen