Control of Sindbis virus infection by antibody in interferon-deficient mice.
Antibodies clear Sindbis virus from infected animals through an unknown mechanism. To determine whether interferon-induced pathways are required for this clearance, we examined mice which are unable to respond to alpha/beta interferon or gamma interferon. Although extremely susceptible to infection, such mice survived and completely cleared virus if antibodies against Sindbis virus were given.
Byrnes
A P
AP
Department of Molecular Microbiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205, USA.
Durbin
J E
JE
Griffin
D E
DE
D000375:Aging; D018354:Alphavirus Infections / Q000276:immunology* / Q000401:mortality / Q000821:virology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology*; D002490:Central Nervous System / Q000821:virology; D020805:Central Nervous System Viral Diseases / Q000276:immunology / Q000401:mortality / Q000821:virology; D016898:Interferon-alpha / Q000172:deficiency / Q000502:physiology*; D016899:Interferon-beta / Q000172:deficiency / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012845:Sindbis Virus / Q000276:immunology* / Q000502:physiology; D019562:Viral Load; D014779:Virus Replication
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D016898:Interferon-alpha; D016899:Interferon-beta