title: Probes for imidazoline binding sites: synthesis and evaluation of a selective, irreversible I2 ligand.
abstract: An irreversible ligand (7) has been prepared based on the selective I2 ligand 2-BFI. Compound 7 displayed high affinity and selectivity for I2-sites and has been shown to irreversibly bind to these sites in rat brain. Compound 7 should, therefore, prove an invaluable tool for the further elucidation of I2-site function.
authors.affiliation: School of Chemistry, University of Bristol, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Coates
authors.forename: P
authors.initials: P
authors.lastname: Grundt
authors.forename: E S
authors.initials: ES
authors.lastname: Robinson
authors.forename: D J
authors.initials: DJ
authors.lastname: Nutt
authors.forename: R
authors.initials: R
authors.lastname: Tyacke
authors.forename: A L
authors.initials: AL
authors.lastname: Hudson
authors.forename: J W
authors.initials: JW
authors.lastname: Lewis
authors.forename: S M
authors.initials: SM
authors.lastname: Husbands
mesh_terms: D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D054755:Imidazoline Receptors; D066298:In Vitro Techniques; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008024:Ligands; D019920:Photoaffinity Labels; D051381:Rats; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects; D011955:Receptors, Drug / Q000187:drug effects*
chemical_list: D054755:Imidazoline Receptors; D008024:Ligands; D019920:Photoaffinity Labels; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug