Simultaneous interaction of steroidal drugs with gamma- and hydroxypropyl-beta-cyclodextrin studied by charge-transfer chromatography.
The simultaneous interaction of 15 steroidal drugs with tau-cyclodextrin (tauCD) and hydroxypropyl-beta-CD (HPbetaCD) was determined by charge transfer chromatography and the relative strength of interaction was calculated for each drug-tauCD-HPbetaCD ternary complex. The mixture of CDs interacted with each steroidal drugs decreasing the lipophilicity of the guest molecules. The chemical structure of steroidal drugs markedly influenced their capacity to interact with the mixture of CDs, the more lipophilic compounds formed stronger complexes with CDs. In the overwhelming majority of cases the stability of drug-tauCD-HPbetaCD system was higher than those of binary (drug-tauCD and drug-HPbetaCD) system indicating the probability of ternary complex formation. The data indicated that the ternary complex formation has to be taken into consideration in pharmaceutical formulations containing more than one type of CD or CD derivatives.
Cserháti
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Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest. forgacs@cric.chemres.hu
Forgács
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D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002855:Chromatography, Thin Layer; D003505:Cyclodextrins / Q000737:chemistry*; D000432:Methanol; D012044:Regression Analysis; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000737:chemistry*; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins
D003505:Cyclodextrins; D012997:Solvents; D013256:Steroids; D047392:beta-Cyclodextrins; D047408:gamma-Cyclodextrins; C479659:hydroxypropyl-gamma-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C023792:gamma-cyclodextrin; D000432:Methanol