Drug resistance in human helminths: current situation and lessons from livestock.
In this review the available reports on drug resistance in human helminths, particularly hookworms and schistosomes, are critically analyzed. The experiences with helminths of livestock are then reviewed, in particular the factors contributing to the development of anthelmintic resistance, the mechanisms and genetics of resistance to various anthelmintic classes, and the methods available for detection. These experiences appear to be worryingly similar and relevant to the potential development of drug resistance in human helminths. Recommendations to reduce its risks are suggested.
Geerts
S
S
Institute of Tropical Medicine, B-2000 Antwerp, Belgium. sgeerts@itg.be
Gryseels
B
B
D000818:Animals; D000829:Animals, Domestic; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D004351:Drug Resistance / Q000235:genetics; D006373:Helminthiasis / Q000188:drug therapy / Q000469:parasitology; D006374:Helminthiasis, Animal / Q000188:drug therapy / Q000469:parasitology; D006376:Helminths / Q000187:drug effects* / Q000235:genetics; D006801:Humans
D000871:Anthelmintics