title: [Mesenteric vein and inferior vena cava thrombosis: disseminated intravascular coagulation and/or G 20210 A mutation of the prothrombin gene?].
abstract: The authors report the case of a 30-year-old man who died from pulmonary embolism and multiorgan failure caused by mesenteric and inferior vena cava thrombosis. The patient was found heterozygous for the prothrombin gene variant (G 20210 A). The family study showed the same asymptomatic anomaly in his brother. This recently described mutation is associated with an increased risk for venous thrombosis. The investigations and treatment of mesenteric venous thrombosis are discussed.
authors.affiliation: Département d'anesthésie-réanimation chirurgicale et médecine d'urgence, Centre hospitalier universitaire Côte-de-Nacre, Caen, France.
authors.forename: C
authors.initials: C
authors.lastname: Leclerc
authors.forename: M
authors.initials: M
authors.lastname: Fretigny
authors.forename: C
authors.initials: C
authors.lastname: Jehan
authors.forename: A
authors.initials: A
authors.lastname: Le Querrec
authors.forename: J L
authors.initials: JL
authors.lastname: Hanouz
authors.forename: J L
authors.initials: JL
authors.lastname: Gérard
authors.forename: H
authors.initials: H
authors.lastname: Bricard
mesh_terms: D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000235:genetics; D017809:Fatal Outcome; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000209:etiology* / Q000235:genetics; D008642:Mesenteric Veins; D009102:Multiple Organ Failure / Q000209:etiology; D009154:Mutation / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D011655:Pulmonary Embolism / Q000209:etiology; D014682:Vena Cava, Inferior; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics
chemical_list: D011516:Prothrombin