Efficacy of bothropic antivenom and its IgG(T) fraction in restoring fibrinogen levels of Bothrops jararaca envenomed mice.
Bothropic antivenom and its IgG(T) fraction, administered 4 h after experimental envenoming by Bothrops jararaca in Swiss mice, were compared for their abilities to restore fibrinogen 24 or 48 h after treatment. IgG(T) was able to normalise fibrinogen levels as efficiently as conventional antivenom. As IgG(T) also neutralises most anti-toxic activities of Bothrops venom, our results suggest that IgG(T) could be a better alternative treatment for envenoming due to the reduced amount of extraneous proteins, which may facilitate the induction of early adverse reactions.
Fernandes
I
I
Laboratório de Immunopatologia, Instituto Butantan, São Paulo, Brazil. irenefer@usp.br
Tavares
F L
FL
Sano-Martins
I S
IS
Takehara
H A
HA
D000818:Animals; D000997:Antivenins / Q000494:pharmacology*; D017837:Bothrops; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors*; D005340:Fibrinogen / Q000378:metabolism*; D007074:Immunoglobulin G / Q000494:pharmacology*; D051379:Mice
D000997:Antivenins; D003435:Crotalid Venoms; D007074:Immunoglobulin G; D005340:Fibrinogen