title: Ethnic differences in intestinal disaccharidase values in children in Finland.
abstract: BACKGROUND
  Intestinal disaccharidase activities tend to be low in villous atrophy, but there are only a few reports of enzyme activities in children with normal villous architecture.
  
  
  METHODS
  In the current study the data were reviewed on disaccharidase activities in duodenal biopsy specimens of normal villous structure in 223 children undergoing upper gastrointestinal endoscopy in 1997 and 1998. The ancestry was Finnish in 188 children (median age 8.0 years; range, 0.2-18 years), African in 27 children (median age 5.0 years; range, 1-13 years), and other in eight children.
  
  
  RESULTS
  The mean activities of lactase, sucrase, and maltase were significantly higher in Finnish children than in children of African origin (P < 0.0001, P < 0.002, and P < 0.02, respectively). Lactase activity decreased with increasing age (P < 0.001), but age had no significant effect on maltase and sucrase activities. Among Finnish children, 31% (59/188) had lactase activity below the established reference range of 20 units (units are micromoles of substrate hydrolyzed per minute at 37 degrees C per gram of protein) and one child had a probable sucrase-isomaltase deficiency. When these 60 children with low enzyme activities were excluded, the geometric means were lactase, 35.7 units (95% confidence interval [CI], 32.8-38.6 units); maltase, 241 units (95% CI, 225-258 units); and sucrase, 57.5 units (95% CI, 53.5-61.6 units). Among the children of African origin, lactase activity was decreased in 67% (18/27). All three enzyme activities were decreased in parallel more often among the African children (8/27) than among the Finnish children (9/188; P < 0.002).
  
  
  CONCLUSIONS
  Ethnicity has a strong effect on disaccharidase values in children with normal villous structure. African children have lower activities of lactase, sucrase, and maltase in duodenal specimens than do children of Finnish origin.
authors.affiliation: Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland.
authors.forename: K L
authors.initials: KL
authors.lastname: Kolho
authors.forename: E
authors.initials: E
authors.lastname: Savilahti
mesh_terms: D000293:Adolescent; D000349:Africa / Q000208:ethnology; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004186:Disaccharidases / Q000378:metabolism*; D004386:Duodenum / Q000201:enzymology / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D005006:Ethnicity; D005387:Finland; D016481:Helicobacter Infections / Q000201:enzymology; D016480:Helicobacter pylori; D006801:Humans; D007223:Infant; D007422:Intestines / Q000201:enzymology*; D043322:Lactase; D012016:Reference Values; D013393:Sucrase / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D004186:Disaccharidases; D043322:Lactase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D013393:Sucrase