title: Baroreceptors, alpha1-adrenergic receptors, and regulation of mesenteric blood flow.
abstract: In the mesenteric circulation of the rat a myogenic autoregulatory system operates at 0.1-0.15 Hz. Negative admittance phase in the region above 0.2 Hz suggested operation of an arterial baroreflex. The present study was designed to test this interpretation and to identify the neurotransmitter involved. In rats anesthetized with isoflurane, blood pressure and mesenteric blood flow (transit time ultrasound) were measured with central mechanisms intact, after sinoaortic denervation, and after denervation of the mesenteric bed. Sinoaortic denervation abrogated the negative phase in the band from 0.3 to 0.6 Hz and increased admittance gain in this region. Subsequent mesenteric denervation had no further effect on the pressure-flow transfer function. In a separate experiment, alpha1-adrenergic blockade reduced, but did not remove, the negative admittance phase in the 0.2- to 0.5-Hz band without altering admittance gain. It is concluded that the baroreflex acting on the mesenteric circulation can be identified by admittance phase, but that admittance gain is uninformative. Part of the response is mediated by alpha1-adrenergic transmission.
authors.affiliation: Lady Davis Institute and Division of Nephrology, Sir Mortimer B. Davis-Jewish General Hospital, Montréal, QC, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Abu-Amarah
authors.forename: W A
authors.initials: WA
authors.lastname: Cupples
mesh_terms: D000818:Animals; D007530:Isoflurane / Q000494:pharmacology; D008297:Male; D010656:Phenylephrine / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*; D013152:Splanchnic Circulation
chemical_list: D018340:Receptors, Adrenergic, alpha-1; D010656:Phenylephrine; D007530:Isoflurane; D011224:Prazosin