title: Intracellular calcium releases facilitate induction of long-term depression.
abstract: In visual cortex layer II/III pyramidal neurons, long-term depression (LTD) of synaptic currents was induced by a combination of the intracellular increase of inositol-1,4,5-trisphosphate (IP(3)), achieved by photolyzing caged-IP(3), and the tetanization to nearby cortex, but not by either of these two procedures alone. A facilitatory role of an IP(3)-induced calcium release in LTD is suggested.
authors.affiliation: Department of Integrative Brain Science, Kyoto University Graduate School of Medicine, 606-8501, Kyoto, Japan. f50207@sakura.kudpc.kyoto-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Isomura
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D017774:Long-Term Potentiation; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure
chemical_list: D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium