Effect of a polysaccharide (TAP) from the fruiting bodies of Tremella aurantia on glucose metabolism in mouse liver.
An acidic polysaccharide (TAP) obtained from the fruiting bodies of Tremella aurantia significantly increased the activities of glucokinase, hexokinase, and glucose-6-phosphate dehydrogenase, and decreased the activity of glucose-6-phosphatase in normal and diabetic mouse liver after intraperitoneal administration, while the glycogen content in the liver was reduced. Furthermore, TAP lowered the plasma cholesterol level in normal and diabetic mice.
Kiho
T
T
Department of Pharmaceutics, Gifu Pharmaceutical University, Japan. kiho@gifu-pu.ac.jp
Morimoto
H
H
Kobayashi
T
T
Usui
S
S
Ukai
S
S
Aizawa
K
K
Inakuma
T
T
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D011134:Polysaccharides / Q000494:pharmacology*
D007328:Insulin; D008112:Liver Glycogen; D011134:Polysaccharides; D002784:Cholesterol; D005947:Glucose