title: Bleeding and selective serotonin reuptake inhibitors in childhood and adolescence.
abstract: The selective serotonin reuptake inhibitors (SSRIs) are becoming widely used in children and adolescents, with possible unexpected side effects being observed over time. SSRIs have been associated with bleeding in adults who have unremarkable routine hematologic laboratory results except abnormal bleeding time or platelet counts in few cases. Given the increase of pediatric SSRI prescriptions, in this article we describe five children, ages 8 through 15, who developed bruising or epistaxis 1 week to 3 months after starting SSRI treatment. It is possible that the effects SSRI on platelet functioning are causing the bleeding observed in some patients and/or that a separate coagulopathy is present and contributing to bleeding. The subject matter deserves future investigation.
authors.affiliation: Department of Child Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Lake
authors.forename: B
authors.initials: B
authors.lastname: Birmaher
authors.forename: S
authors.initials: S
authors.lastname: Wassick
authors.forename: K
authors.initials: K
authors.lastname: Mathos
authors.forename: A K
authors.initials: AK
authors.lastname: Yelovich
mesh_terms: D000293:Adolescent; D002648:Child; D003288:Contusions / Q000139:chemically induced; D004844:Epistaxis / Q000139:chemically induced; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D020280:Sertraline / Q000009:adverse effects*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline