title: Biologically variable pulsation improves jugular venous oxygen saturation during rewarming.
abstract: BACKGROUND
  Conventional pulsatile (CP) roller pump cardiopulmonary bypass (CPB) was compared to computer controlled biologically variable pulsatile (BVP) bypass designed to return beat-to-beat variability in rate and pressure with superimposed respiratory rhythms. Jugular venous O2 saturation (SjvO2) below 50% during rewarming from hypothermia was compared for the two bypass techniques. A SjvO2 less than 50% during rewarming is correlated with cognitive dysfunction in humans.
  
  
  METHODS
  Pigs were placed on CPB for 3 hours using a membrane oxygenator with alpha-stat acid base management and arterial filtration. After apulsatile normothermic CPB was initiated, animals were randomized to CP (n = 8) or BVP (roller pump speed adjusted by an average of 2.9 voltage output modulations/second; n = 8), then cooled to a nasopharyngeal temperature of 28 degrees C. During rewarming to stable normothermia, SjvO2 was measured at 5 minute intervals. The mean and cumulative area for SjvO2 less than 50% was determined.
  
  
  RESULTS
  No between group difference in temperature existed during hypothermic CPB or during rewarming. Mean arterial pressure, arterial partial pressure O2, and arterial partial pressure CO2 did not differ between groups. The hemoglobin concentration was within 0.4 g/dL between groups at all time periods. The range of systolic pressure was greater with BVP (41 +/- 18 mm Hg) than with CP (12 +/- 4 mm Hg). A greater mean and cumulative area under the curve for SjvO2 less than 50% was seen with CP (82 +/- 96 versus 3.6% +/- 7.3% x min, p = 0.004; and 983 +/- 1158 versus 42% +/- 87% x min; p = 0.004, Wilcoxon 2-sample test).
  
  
  CONCLUSIONS
  Computer-controlled BVP resulted in significantly greater SjvO2 during rewarming from hypothermic CPB. Both mean and cumulative area under the curve for SjvO2 less than 50% exceeded a ratio of 20 to 1 for CP versus BVP. Cerebral oxygenation is better preserved during rewarming from moderate hypothermia with bypass that returns biological variability to the flow pattern.
authors.affiliation: Department of Anesthesia, University of Manitoba, Winnipeg, Canada. amutch@ms.umanitoba.ca
authors.forename: W A
authors.initials: WA
authors.lastname: Mutch
authors.forename: R K
authors.initials: RK
authors.lastname: Warrian
authors.forename: G M
authors.initials: GM
authors.lastname: Eschun
authors.forename: L G
authors.initials: LG
authors.lastname: Girling
authors.forename: L
authors.initials: L
authors.lastname: Doiron
authors.forename: M S
authors.initials: MS
authors.lastname: Cheang
authors.forename: G R
authors.initials: GR
authors.lastname: Lefevre
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001921:Brain / Q000098:blood supply*; D002315:Cardiopulmonary Bypass / Q000295:instrumentation; D002534:Hypoxia, Brain / Q000209:etiology; D007601:Jugular Veins; D010100:Oxygen / Q000097:blood*; D011673:Pulsatile Flow; D017694:Rewarming / Q000379:methods*; D013552:Swine
chemical_list: D010100:Oxygen