Synthesis of 7-substituted tetracycline derivatives.
[formula: see text] The synthesis of 7-substituted tetracycline derivatives has been accomplished in high yield from 7-halotetracyclines by modified Suzuki and Stille coupling protocols. These novel derivatives may serve as a new class of tetracycline antibiotics effective against multi-antibiotic-resistant bacteria.
Koza
D J
DJ
Department of Science and Allied Health, Mount Ida College, Newton, Massachusetts 02459, USA. dkoza@mountida.edu
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D013754:Tetracyclines / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D013754:Tetracyclines