Abortive oncogeny and cell cycle-mediated events in Alzheimer disease.
Alzheimer disease, the leading cause of senile dementia, is characterised by the degeneration of select neuronal populations. While the mechanism(s) underlying such cell loss are largely unknown, recent findings indicate inappropriate re-entry into the cell cycle resembling an abortive oncogeny. In postmitotic neurons, such mitotic re-entrance is deleterious and one that involves virtually the entire spectrum of the described pathological events in Alzheimer disease including, ultimately, cell death.
Raina
A K
AK
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Zhu
X
X
Monteiro
M
M
Takeda
A
A
Smith
M A
MA
D000544:Alzheimer Disease / Q000473:pathology*; D017209:Apoptosis; D002453:Cell Cycle; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D009474:Neurons / Q000166:cytology*; D009857:Oncogenes
D006133:Growth Substances