[Is there an increase of serum antisperm antibodies following surgery in the cervical transformation zone for cervical intraepithelial neoplasia (CIN)?].
OBJECTIVE
This prospective controlled study was performed to investigate whether operative procedures of the uterine cervix lead to a change in the titre of humoral antispermatozoal antibodies.


METHODS
Humoral antispermatozoal antibodies were measured using an ELISA in 15 patients undergoing cervical scraping, 20 having conisation, 10 having a loop excision before and at least 3 months after surgery as well as in 10 fertile women as a control group.


RESULTS
There were no significant differences in age between groups, in the distribution of initial and final levels of humoral antispermatozoal antibodies (IgG, IgA), and no significant change of the antibody titres (pre- and postoperative) within the individual groups.


CONCLUSIONS
In patients of fertile age, the formation of humoral isoantibodies does not have to be taken into account in selecting the method of diagnosing and treating cervical intraepithelial neoplasia (CIN).
Nawroth
F
F
Klinik für Gynäkologie und Geburtshilfe, Funktionsbereich Gynäkologische Endokrinologie und Fortpflanzungsmedizin, Klinikum Neubrandenburg. Frank.Nawroth@medizin.uni-koeln.de
Sudik
R
R
Wolf
C
C
Quaas
J
J
D000328:Adult; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000276:immunology / Q000601:surgery*; D019092:Conization / Q000009:adverse effects; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007518:Isoantibodies / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013094:Spermatozoa / Q000276:immunology*; D002578:Uterine Cervical Dysplasia / Q000097:blood / Q000276:immunology* / Q000601:surgery*
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007518:Isoantibodies