Trisomy of chromosome 10 in two cases of ovarian carcinoma.
Simple numerical chromosome aberrations have been observed in tumorigenesis and may point to indicative initiating or early events in tumorigenesis. We have identified two cases of ovarian carcinomas with trisomy of chromosome 10 using conventional GTG-banding and fluorescence in situ hybridization. This is, to our knowledge, the first report of trisomy 10 as a simple karyotypic abnormality observed in ovarian carcinoma. These results suggest that further studies investigating whether chromosome 10 genes are associated with the pathogenesis of some ovarian tumors are warranted.
Wang
J
J
Cytogenetics Laboratory, the Montreal Children's Hospital, Departments of Human Genetics and Pathology, McGill University, Montréal, Québec, Canada.
Mes-Masson
A M
AM
Tonin
P N
PN
Provencher
D
D
Eydoux
P
P
D018262:Adenocarcinoma, Clear Cell / Q000235:genetics* / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000235:genetics* / Q000473:pathology; D000328:Adult; D002871:Chromosome Banding; D020223:Chromosome Painting; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D014314:Trisomy / Q000235:genetics*; D014407:Tumor Cells, Cultured