Solid-phase synthesis of cyclic imides.
A cyclative cleavage strategy for the synthesis of cyclic imides on a polystyrene resin is described. After optimization of the cleavage conditions, a small array of succinimides and phthalimides was synthesized. The methodology was then applied to a drug discovery project, in which it was used to synthesize a new class of delta-opioid receptor ligand by both automated and manual methods.
Barn
D R
DR
Medicinal Chemistry Department, Organon Laboratories Ltd., Scotland, U.K.
Morphy
J R
JR
D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D007094:Imides / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D015394:Molecular Structure; D011137:Polystyrenes; D012116:Resins, Plant; D013329:Structure-Activity Relationship
D007094:Imides; D007202:Indicators and Reagents; D011137:Polystyrenes; D012116:Resins, Plant