Case study of paired cadaver renal allografts from the same donor: influence of local DIC kidney and concomitant acute rejection on early graft outcome.
We report the clinical course of 2 recipients whose renal allografts were obtained from the same cadaver donor after cardiac arrest. The recipients showed different outcomes after transplantation. Graft biopsy after reperfusion revealed disseminated intravascular coagulation (so-called DIC kidney) and severe acute tubular necrosis (ATN) in both recipients. While one graft showed primary nonfunction, the other graft became functional after a post-operative anuric period. Serial graft biopsies performed during the oligo-anuric period revealed recovery of ATN and no intra-glomerular fibrin thrombi, but development of acute rejection was detected in both recipients. The left kidney graft showed more severe local DIC kidney than the right kidney, as well as more severe acute rejection in the oligo-anuric period. Despite aggressive anti-rejection therapy, the left kidney graft showed primary nonfunction. Therefore, severe acute rejection leading to primary nonfunction might have been related to more severe ischemic injury and more extensive local DIC kidney in the left kidney.
Takeda
A
A
Kidney Center, Nagoya Daini Red Cross Hospital, Aichi, Japan.
Morozumi
K
K
Uchida
K
K
Haba
T
T
Tominaga
Y
Y
Yoshida
A
A
Orihara
A
A
Kobayashi
T
T
Yokoyama
I
I
D000328:Adult; D000368:Aged; D001706:Biopsy; D002102:Cadaver; D004211:Disseminated Intravascular Coagulation / Q000473:pathology*; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000473:pathology; D016030:Kidney Transplantation / Q000276:immunology / Q000473:pathology / Q000502:physiology; D007683:Kidney Tubular Necrosis, Acute / Q000473:pathology; D008875:Middle Aged