Sequence, expression, and location of zebrafish frizzled 10.
Members of the frizzled gene family encode seven-pass transmembrane proteins that function in the interpretation and reception of Wnt-mediated cell-cell communication events. To investigate frizzled function in early zebrafish development, we isolated the maternally contributed frizzled 10 (fz10) gene and localized it to linkage group 8 using radiation hybrid mapping. The cloned zebrafish fz10 is closely related to the fz10 group from other organisms. Zygotic expression of fz10 is observed in the posterior tail mesenchyme, dorsal neural tube, and different parts of the brain.
Nasevicius
A
A
University of Minnesota Medical School, Department of Genetics, Cell Biology, and Development, Institute of Human Genetics, Room 6-160 Jackson Hall, 321 Church Street S.E., Minneapolis 55455, USA.
Hyatt
T M
TM
Hermanson
S B
SB
Ekker
S C
SC
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology / Q000502:physiology; D002874:Chromosome Mapping; D004625:Embryo, Nonmammalian; D051157:Frizzled Receptors; D005775:Gastrula; D018507:Gene Expression Regulation, Developmental; D006257:Head / Q000196:embryology; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D013623:Tail / Q000196:embryology / Q000502:physiology; D015027:Zebrafish / Q000196:embryology / Q000235:genetics*; D029961:Zebrafish Proteins
D051157:Frizzled Receptors; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D029961:Zebrafish Proteins; C492386:fzd10 protein, zebrafish