[Organochlorine compounds and breast cancer--is there a connection between environmental pollution and breast cancer?].
Some organochlorine compounds may have weak oestrogenic effects and are therefore suspected of increasing the risk of breast cancer. The risk of breast cancer was assessed prospectively in relation to the serum concentration of several organochlorines. In all 240 women, who developed breast cancer between 1976 and 1993 were together with 477 breast cancer-free controls enrolled in a cohort-nested case-control study. The serum dieldrin concentration was associated with a significantly increased dose-related risk of breast cancer (Odds Ratio 2.05; 95% confidence interval 1.17-3.57; p for trend 0.01). There was no overall association between risk of breast cancer and DDT or polychlorinated biphenyls. The results support the hypothesis that exposure to oestrogenic organochlorines may increase the risk of breast cancer.
Høyer
A P
AP
H:S Kommunehospitalet, Hovedstadens Center for Prospektive Befolkningsstudier. APH@post8.tele.dk
Grandjean
P
P
Jørgensen
T
T
Brock
J W
JW
Hartvig
H B
HB
D001943:Breast Neoplasms / Q000139:chemically induced*; D016022:Case-Control Studies; D003718:Denmark; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000097:blood; D004967:Estrogens / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D006801:Humans; D007306:Insecticides / Q000009:adverse effects* / Q000097:blood; D008019:Life Style; D011078:Polychlorinated Biphenyls / Q000009:adverse effects* / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors
D004785:Environmental Pollutants; D004967:Estrogens; D007306:Insecticides; D011078:Polychlorinated Biphenyls