title: Primary obstructive megaureter in adults: need for an aggressive management strategy.
abstract: OBJECTIVE
  Primary obstructive megaureter (POM) is an uncommon disease in adults. We reviewed our experience with this disease to determine the clinical profile, management and prognosis of this disease in adults.
  
  
  METHODS
  We studied 37 adults with POM who presented from January 1989 to December 1998. Their clinical presentation, renal function, radiologic data, complications, treatment as well as the results and follow-up were studied.
  
  
  RESULTS
  The patients' age ranged from 13 to 52 years. Male:female ratio was 27:10. Seven patients had bilateral disease. All patients were symptomatic excepting 2. Complications at presentation were loin pain (26 cases), urinary infection (15 cases), calculus disease (17 cases), azotaemia (5 cases), and obstructive jaundice (1 case). Associated congenital anomalies included contralateral renal agenesis (2 cases), posterior urethral valve (1 case) and exstrophy of bladder (1 case). Thirty-four patients required surgical intervention. Of these, 26 patients underwent ureteroneocystostomy (UNC) with ureteral tailoring in 18 patients; 4 patients were treated endoscopically by ureteric meatotomy and stenting, 2 patients with nonfunctioning kidney by nephroureterectomy, 2 patients in advanced renal failure by percutaneous nephrostomy alone. In 4 out of 5 patients uraemia did not improve despite adequate drainage.
  
  
  CONCLUSIONS
  The majority of adults with POM are symptomatic, have complications and require surgical correction. Complications of stone formation (46%) and renal failure (13.5%) are unusually common in adults. Once renal failure is advanced, intervention appears futile, therefore, it is imperative to treat these patients as soon as possible. Surgical correction by ureteric re-implantation is effective and has low morbidity.
authors.affiliation: Department of Urology, All India Institute of Medical Sciences, New Delhi.
authors.forename: L N
authors.initials: LN
authors.lastname: Dorairajan
authors.forename: A K
authors.initials: AK
authors.lastname: Hemal
authors.forename: N P
authors.initials: NP
authors.lastname: Gupta
authors.forename: S N
authors.initials: SN
authors.lastname: Wadhwa
mesh_terms: D000293:Adolescent; D000328:Adult; D004108:Dilatation, Pathologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D014513:Ureter / Q000473:pathology; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging / Q000628:therapy*