Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation.
Several retinoid binding proteins and nuclear receptors are specifically expressed in murine placenta. However, little is known about molecular events and target genes regulated by retinoids during placentation. Here, we report that several retinoic acid-inducible (Stra) genes, originally isolated by a differential screening procedure, exhibit specific expression patterns in mouse placental tissues. Three Stra genes, including the ephrinB1 receptor tyrosine kinase ligand, are prominently expressed in the regions of exchanges between maternal and embryonic circulations, i.e. the yolk sac and/or the labyrinthine zone of the mature placenta. The Meis2 homeobox gene appears to be specifically expressed in maternally-derived cell populations. Three other Stra genes, including the AP-2-related gene AP-2gamma, are differentially expressed in the trophoblastic cell lineage. Thus, retinoids may regulate various signaling pathways in specific placental cell-types.
Sapin
V
V
Unité INSERM 384, Laboratoire de Biochimie Médicale, Faculté de Médecine, 28 Place Henri Dunant, BP 38, 63001 Clermont-Ferrand, Cedex, France.
Bouillet
P
P
Oulad-Abdelghani
M
M
Dastugue
B
B
Chambon
P
P
Dollé
P
P
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D036387:Ephrin-B1; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014212:Tretinoin / Q000378:metabolism* / Q000494:pharmacology; D014327:Trophoblasts / Q000502:physiology
D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D036387:Ephrin-B1; D018398:Homeodomain Proteins; D008565:Membrane Proteins; C102641:Mrg1 protein, mouse; D011506:Proteins; C108001:Stra6 protein, mouse; C102019:Stra8 protein, mouse; C583890:Tfap2c protein, mouse; D050656:Transcription Factor AP-2; D014157:Transcription Factors; D014212:Tretinoin