[The dependence of the temperature response to pyrogens on the ambient temperature and the initial body temperature].
The dependence of the temperature response to injection of Freund's complete adjuvant (FCA) containing killed and dried Mycobacterium butyricum on ambient temperature within 8-10, 14-16, 20-22, 26-28 degrees C ranges and initial body temperature was studied in experiments on rats, guinea pigs, and rabbits. The duration of the hyperthermic response was maximal at an ambient temperature 14-16 degrees C, and its dynamics can be divided in 2 phases, initial febrile and subsequent subfebrile. An increase in rectal temperature after application of the agent was the higher the lower was its initial value and vice versa. The hyperthermic response to FCA did not occur at 8-10 degrees C.
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D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology*; D006168:Guinea Pigs; D008297:Male; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012007:Rectum; D013696:Temperature; D013821:Thermometers; D013997:Time Factors
D011749:Pyrogens; D005620:Freund's Adjuvant