Increased expression of sialyl Le(x) antigen in non-polypoid growth type of colorectal carcinoma.
Colorectal carcinoma can be morphologically divided into two different categories, namely polypoid growth (PG-type) and non-polypoid growth (NPG-type). To ascertain whether the expression of sialyl Le(x) antigen correlates with biologically and clinically important differences, an immunohistochemical assay was performed in 30 PG-type and 119 NPG-type cancers. In contrast to PG-type, the characteristics of the NPG-type include (1) an increased expression of sialyl Le(x); (2) a high rate of lymph node metastasis; (3) a high proportion of moderately differentiated adenocarcinoma cells; (4) young age of onset. It is concluded that differences in sialyl Le(x) expression between the PG-type and NPG-type cancers may be at least partly responsible for different tumor progression behavior.
Nakagoe
T
T
First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan. nakagoe@net.nagasaki-u.ac.jp
Fukushima
K
K
Nanashima
A
A
Sawai
T
T
Tsuji
T
T
Jibiki
M
M
Yamaguchi
H
H
Yasutake
T
T
Ayabe
H
H
Matuo
T
T
Tagawa
Y
Y
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D017668:Age of Onset; D000368:Aged; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016256:Lewis X Antigen / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009844:Oligosaccharides / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016016:Proportional Hazards Models; D000080506:Sialyl Lewis X Antigen; D015996:Survival Rate; D015854:Up-Regulation
D016256:Lewis X Antigen; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen