Late asthmatic reaction caused by naphthylene-1,5 diisocyanate.
After occupational exposure to napthylene-1,5 diisocyanate (NDI) for 2 years, a 33-year-old female worker developed work-related asthma attacks. Occupational-type exposure tests with NDI resulted in a late asthmatic response, whereas a corresponding challenge test with 4,4'-methylenediphenyl diisocyanate was negative. We conclude that NDI exposure in the range of its occupational exposure limit caused occupational asthma in this subject.
Baur
X
X
Berufsgenossenschaftliches Forschungsinstitut für Arbeitismedizin (BGFA), Bochum, Germany. baur@bgfa:ruhr-uni-bochum.de
Wieners
D
D
Marczynski
B
B
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D018663:Adrenergic Agents / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D017953:Isocyanates / Q000506:poisoning*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000188:drug therapy; D013566:Sympathomimetics / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D018663:Adrenergic Agents; D017953:Isocyanates; D013566:Sympathomimetics; C023446:1,5-naphthylene di-isocyanate