Plasmodium falciparum clones resistant to (S)-9-(3-hydroxy-2-phosphonylmethoxy-propyl)adenine carry amino acid substitutions in DNA polymerase delta.
Smeijsters
L J
LJ
Department of Parasitology and Tropical Veterinary Medicine, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Zijlstra
N M
NM
Veenstra
J
J
Verstrepen
B E
BE
Heuvel
C
C
Overdulve
J P
JP
de Vries
E
E
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology*; D001665:Binding Sites; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics / Q000528:radiation effects; D016415:Sequence Alignment; D014466:Ultraviolet Rays
D000977:Antiparasitic Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; C050127:9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine; D004259:DNA-Directed DNA Polymerase; D000225:Adenine