[Pathophysiology of collateral coronary circulation].
The study presents the concepts of collateral circulation in the heart. These vessels can reduce the fatal consequences of occlusion of large coronary artery. There are described two mechanisms of its growth: vasculogenesis (mitosis of endothelial cells, and smooth muscle cells), and angiogenesis (migration and mitosis of endothelial cells). These processes are triggered by ischemia and by expression of peptide growth factors. Growth factors are produced by macrophages and often are found in inflammation tissue. Therapeutic angiogenesis remains controversial, however in the near future stimulation of angiogenesis by peptides, drugs and gene therapy will have a place in therapy of ischemic heart disease.
Pogorzelska-Dyrbuś
J
J
I Katedry i Zakładu Histologii i Embriologii Slaskiej Akademii Medycznej w Katowicach.
Dyrbuś
K
K
D003097:Collateral Circulation / Q000502:physiology*; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000378:metabolism / Q000503:physiopathology*; D006133:Growth Substances / Q000378:metabolism; D006801:Humans
D006133:Growth Substances