title: Autoapheresis and intraoperative blood salvage in oncologic surgery.
abstract: Transfusion of predeposit or salvaged autologous blood has continued to grow since the 1980s. Issues such as the indications for use and cost effectiveness as well as the safety of autologous blood salvaged during cancer surgery have emerged and should be addressed. The concern for possible contamination of autologous RBC with cancer cells responsible for metastasis has limited the use of autologous salvaged blood in cancer patients. Nevertheless, clinical experience has been gained on the use of salvaged blood in patients with colorectal, gastric, renal, hepatic, breast, bladder and lung cancer. No evidence has been reported showing an increase in metastasis or a decrease in patient survival, in spite of the obvious demonstration that salvaged blood is contaminated with viable tumor cells which are not washed out of the RBC layer during intraoperative blood salvage (IOBS). However, a number of limitations have hampered the widespread use of IOBS in these patients and the technique is not well established. Increasing knowledge of the deleterious effects of allogeneic blood transfusion both in terms of the increased number of viral or bacterial infections and the down-regulation of the patient's immune system have recalled attention to IOBS and to the techniques such as filtration, which might reduce the risk of reinfusion of cancer cells, or totally eliminate the risks such as irradiation has been proposed by Hansen's group. This paper reviews the topic with some emphasis on our personal experience with gamma and X-ray irradiation of salvaged blood in a large reference hospital, where IOBS and filtration of salvaged blood were established for use in cancer patients in 1993 and 1996.
authors.affiliation: Immunohematology Services, San Martino University Hospital, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Valbonesi
authors.forename: R
authors.initials: R
authors.lastname: Bruni
authors.forename: G
authors.initials: G
authors.lastname: Lercari
authors.forename: G
authors.initials: G
authors.lastname: Florio
authors.forename: P
authors.initials: P
authors.lastname: Carlier
authors.forename: F
authors.initials: F
authors.lastname: Morelli
mesh_terms: D001769:Blood / Q000528:radiation effects; D001781:Blood Component Removal / Q000379:methods*; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000379:methods*; D002588:Cesium Radioisotopes; D017558:Elective Surgical Procedures; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms / Q000097:blood / Q000601:surgery*; D009360:Neoplastic Cells, Circulating / Q000528:radiation effects; D016896:Treatment Outcome
chemical_list: D002588:Cesium Radioisotopes