Lymphocytic hypophysitis in a patient with systemic lupus erythematosus.
A case of lymphocytic hypophysitis in a patient with systemic lupus erythematosus is described. A 20-year-old woman was admitted to our hospital with generalized myalgia and facial rash in May 1998. The patient had a medical history, physical examination, and laboratory findings compatible with systemic lupus erythematosus (SLE). Headache and nausea had developed 3 months previously and worsened over the following months. Hormonal investigation showed hypopituitarism except for prolactin. A magnetic resonance image of the brain showed a mass lesion in the pituitary fossa. A trans-sphenoidal surgical procedure was performed which revealed a dark-yellowish hematoma. Microscopic examination showed diffuse infiltration of lymphocytes and plasma cells with fibrosis in the anterior pituitary. Post-operatively the patient's headaches and nausea resolved. This indicates that lymphocytic hypophysitis may be associated with SLE.
Ji
J D
JD
Hospital for Rheumatic Disease, Hanyang University Medical Center, Korea.
Lee
S Y
SY
Choi
S J
SJ
Lee
Y H
YH
Song
G G
GG
D000328:Adult; D005260:Female; D006406:Hematoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007018:Hypopituitarism / Q000150:complications; D007249:Inflammation / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008214:Lymphocytes / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D010902:Pituitary Gland / Q000098:blood supply / Q000473:pathology