Non-conventional locations of hormone receptors (binding sites). A review.
Recent findings on the noncanonical positions of some well-known extracellular mediators and their receptors are reviewed. Peptide hormones (insulin) and/or their binding sites (cell membrane insulin receptor, nuclear insulin receptor); steroid hormones (corticosteroids and estrogens) and their putative membrane receptors are in the scope of this paper. The possible roles of these unusually located receptors in the intracellular signal propagation and physiological responses are also discussed.
Fülöp
A K
AK
Department of Genetics, Cell- and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary.
Hegyesi
H
H
D000818:Animals; D011972:Receptor, Insulin / Q000302:isolation & purification*; D018160:Receptors, Cytoplasmic and Nuclear / Q000302:isolation & purification*; D011987:Receptors, Steroid / Q000302:isolation & purification*; D013769:Tetrahymena pyriformis
D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D011972:Receptor, Insulin