title: Sacropelvic resection for recurrent anorectal cancer. A multidisciplinary approach.
abstract: A multimodal approach including preoperative external beam radiation, surgical resection, and intraoperative electron radiation was used in 23 patients with locally advanced anal or recurrent rectal cancers involving the sacrum. The proximal extent of complete sacral resection was S2 in three patients, S3 in 12 patients, S4 in two patients, and S5 in one patient. The tumor was confined to the anterior sacral cortex in five patients. The resection was marginal in 10, contaminated marginal in 11, and intralesional in two patients. At 19 to 54 months of followup, five patients are alive without evidence of disease and four are alive with disease. Twelve patients died of their disease, and two died of other causes. There was a mean survival of 32.9 months for the patients who were alive at followup. Kaplan-Meier survival for all patients was 82% at 1 year and 73% at 2 years, with death of disease as an endpoint. Thirteen (57%) patients had another local recurrence develop at a mean of 17.2 months. Eight (35%) patients had metastatic disease develop at a mean of 16.3 months. Proper patients selection is important in ensuring a favorable outcome from this aggressive surgery.
authors.affiliation: University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Nelson
authors.forename: L L
authors.initials: LL
authors.lastname: Gunderson
authors.forename: F H
authors.initials: FH
authors.lastname: Sim
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010388:Pelvis / Q000601:surgery*; D011183:Postoperative Complications; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D012447:Sacrum / Q000601:surgery*; D015996:Survival Rate