Understanding enediyne-protein interactions: diyl atom transfer results in generation of aminoacyl radicals.
[formula: see text] The origin of the protein modulating capacity of enediynes has been probed. A series of synthetic enediyne-derived diyls participated in atom transfer chemistry with a labeled amino acid. Subsequent experiments suggest that diyl radicals may modulate protein architecture via formation of captodatively stabilized radicals.
Jones
G B
GB
Department of Chemistry, Northeastern University, Boston, Massachusetts 02115, USA. grjones@lynx.neu.edu
Plourde
G W
GW
Wright
J M
JM
D000475:Alkenes; D000480:Alkynes; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D001059:Apoproteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry*; D009353:Zinostatin
D000475:Alkenes; D000480:Alkynes; D000596:Amino Acids; D001059:Apoproteins; D011506:Proteins; D009353:Zinostatin