Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates.
Two new tprD alleles have been identified in Treponema pallidum: tprD2 is found in 7 of 12 T. pallidum subsp. pallidum isolates and 7 of 8 non-pallidum isolates, and tprD3 is found in one T. pallidum subsp. pertenue isolate. Antibodies against TprD2 are found in persons with syphilis, demonstrating that tprD2 is expressed during infection.
Centurion-Lara
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A
Departments of Medicine and Pathobiology, University of Washington, Seattle, Washington 98195-7185, USA.
Sun
E S
ES
Barrett
L K
LK
Castro
C
C
Lukehart
S A
SA
Van Voorhis
W C
WC
D000483:Alleles; D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000276:immunology; D020440:Gene Duplication; D005798:Genes, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013587:Syphilis / Q000097:blood; D014210:Treponema pallidum / Q000235:genetics* / Q000276:immunology
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; C406409:Tpr protein, Treponema