Ethambutol affects the spectral and polarisation sensitivity of on-responses in the optic nerve of rainbow trout.
Juvenile rainbow trout (Oncorhynchus mykiss) were given ethambutol (900 mg kg-1 body mass per day) for 4 weeks to examine its effects on vision. Using multi-unit recording from the optic nerve, spectral sensitivity of the on-responses were significantly affected in two regions, 340-440 nm and 600-660 nm. Off-responses were statistically unaffected. Changes in sensitivity to polarised light were also observed with on-responses to vertically-polarized light decreasing relative to horizontally-polarised light. In contrast, off-responses were less affected. The treatment effects were attributed to changes in the relative contribution of the photoreceptor channels as recorded at the level of the optic nerve.
Parkyn
D C
DC
Department of Biology, University of Victoria, BC, Canada.
Hawryshyn
C W
CW
D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D003118:Color Perception / Q000187:drug effects; D004594:Electrophysiology; D004977:Ethambutol / Q000494:pharmacology*; D017686:Oncorhynchus mykiss / Q000502:physiology*; D009900:Optic Nerve / Q000502:physiology*; D014785:Vision, Ocular / Q000187:drug effects*
D000995:Antitubercular Agents; D004977:Ethambutol