Zinc protection of mercury-induced hepatic toxicity in mice.
The actions and interactions of heavy metals on certain organ functions have been of concern, since occupational exposure to certain metals results in impairment of functions. Studies were carried out to determine the effects of zinc (Zn) and mercury (Hg) on murine liver. CD-1 male mice were administered 4 ppm HgCl2, 800 ppm ZnCl2, 4 ppm HgCl2+800 ppm ZnCl2 or deionized water in their drinking water for 12 weeks. Histological evaluation of the liver confirmed the toxic effects of Hg, as well as the normal morphology of the Zn-exposed animals. A combined treatment of both metals resulted in protection of the Hg-induced liver damage by Zn. The results of this experiment indicate that Hg has a toxic effect on liver, while Zn has a protective action against such toxic effects.
Afonne
O J
OJ
Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria.
Orisakwe
O E
OE
Ndubuka
G I
GI
Akumka
D D
DD
Ilondu
N
N
D000818:Animals; D001835:Body Weight; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008628:Mercury / Q000633:toxicity*; D051379:Mice; D009929:Organ Size; D015032:Zinc / Q000494:pharmacology*
D008628:Mercury; D015032:Zinc