title: Initial symptoms of Parkinson's disease with elderly onset.
abstract: OBJECTIVE
  As the incidence of Parkinson's disease (PD) is related to aging, we consider it important to determine how the initial symptoms change with age in order to diagnose early elderly cases of PD accurately.
  
  
  METHODS
  84 patients (age at onset 70.7+/-9.0 years; mean +/-1 SD) were studied to see whether the initial symptoms change according to age.
  
  
  RESULTS
  The prevalence of resting tremor was significantly lower in patients of advanced age (p = 0.041). In contrast, the incidence of postural and gait disorders increased significantly with aging (p = 0.032). The prevalences of rigidity and kinetic disorders, which are important clinical features of PD, were not influenced by aging.
  
  
  CONCLUSIONS
  These findings suggest that the cause of PD is not related to the aging process itself, since the prevalences of all symptoms were not influenced by aging. Knowledge of the prevalence of the initial symptoms of PD may contribute to the accurate diagnosis in early and elderly cases.
authors.affiliation: Department of Neurology, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo, Japan. nagaya2@ibm.net
authors.forename: H
authors.initials: H
authors.lastname: Nagayama
authors.forename: M
authors.initials: M
authors.lastname: Hamamoto
authors.forename: C
authors.initials: C
authors.lastname: Nito
authors.forename: S
authors.initials: S
authors.lastname: Takagi
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D020233:Gait Disorders, Neurologic / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D015995:Prevalence; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D014202:Tremor / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*