Transient focal neurological deficits during pregnancy in carriers of inherited thrombophilia.
OBJECTIVE
The aim of our study was to investigate the association of transient ischemic cerebrovascular events during pregnancy and inherited thrombophilias.


METHODS
The study group comprised previously healthy pregnant women who had their first ischemic event during pregnancy (n=12). The control group included 24 healthy women matched with the study women for age, ethnicity, and smoking status. All women were evaluated for factor V Leiden mutation, methylenetetrahydrofolate reductase C677T gene mutation, the G20210A mutation in the prothrombin gene, and deficiencies of plasma proteins C and S and antithrombin III.


RESULTS
Inherited thrombophilia was detected in 83% of women with transient neurological manifestations compared with 17% of the control group (P<0.001).


CONCLUSIONS
Transient cerebrovascular ischemic events during pregnancy are associated with a high rate of inherited thrombophilias. Pregnant women with focal neurological symptoms should be evaluated for thrombophilia.
Kupferminc
M J
MJ
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ty o.
Yair
D
D
Bornstein
N M
NM
Lessing
J B
JB
Eldor
A
A
D000293:Adolescent; D000328:Adult; D005165:Factor V / Q000032:analysis; D005260:Female; D006579:Heterozygote; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications*; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D011247:Pregnancy; D011248:Pregnancy Complications; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000150:complications* / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)