title: [Substituted benzo[b]thiophenes with anti-leukotriene activity].
abstract: The cyclizing reaction of cinnamic acid (Ia) with thionyl chloride was optimized and a series of 3-chloro-6-subst.benzo[b]thiophene-2-carbonyl chlorides Va-Vn was prepared. Chloride Va was transformed into a series of N-aryl-3-subst. (Cl, OCH3, OH) benzo[b]thiophene-2-carboxamides VII, IX, X. The drugs were subjected to an evaluation of selected antileucotriene activities in vitro and of the anti-inflammatory effect in vivo. In agreement with the assumed mechanism, inhibition of the ear inflammation is conditioned by the antileucotriene activity, whereas inhibition of the carrageen oedema is not due to this mechanism alone.
authors.affiliation: Ustav organické chemie Vysoké skoly chemicko-technologické, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Nic
authors.forename: M
authors.initials: M
authors.lastname: Havelková
authors.forename: M
authors.initials: M
authors.lastname: Terinek
authors.forename: J
authors.initials: J
authors.lastname: Palecek
authors.forename: J
authors.initials: J
authors.lastname: Svoboda
authors.forename: A
authors.initials: A
authors.lastname: Jandera
authors.forename: V
authors.initials: V
authors.lastname: Panajotová
authors.forename: M
authors.initials: M
authors.lastname: Kuchar
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004487:Edema / Q000188:drug therapy; D020024:Leukotriene Antagonists / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D007975:Leukotriene B4 / Q000096:biosynthesis; D051379:Mice; D009504:Neutrophils / Q000378:metabolism; D051381:Rats; D013876:Thiophenes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D020024:Leukotriene Antagonists; D013876:Thiophenes; D007975:Leukotriene B4