Determination of methotrimeprazine in pharmaceutical preparations by visible spectrophotometry.
A spectrophotometric method is described for determination of methotrimeprazine (levomepromazine). The aim of this work was to develop a simple, rapid, precise, and accurate visible spectrophotometric method for determination of methotrimeprazine in tablet, oral solution, and injection. The method is based on methotrimeprazine reaction with bromophenol blue, resulting in a stable, light yellow-green ion-pair complex that, after extraction with chloroform, presented maximum absorption at 409 nm. Beer's law was obeyed in the concentration range from 5.0 to 25.0 micrograms/ml. The proposed standardized method was applied to commercially available and simulated samples. The accuracy of the method was confirmed by recovery tests.
Kedor-Hackmann
E R
ER
Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil. ermkedor@usp.br
Prado
M S
MS
Santoro
M I
MI
D014150:Antipsychotic Agents / Q000032:analysis* / Q000737:chemistry; D004339:Drug Compounding; D006801:Humans; D008728:Methotrimeprazine / Q000032:analysis* / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013053:Spectrophotometry / Q000379:methods* / Q000592:standards
D014150:Antipsychotic Agents; D008728:Methotrimeprazine