The control of blepharospasm by essential fatty acids.
Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from a specific ratio of two free polyunsaturated fatty acids - linoleic acid and alpha-linolenic acid - the eye blinking rate following administration of Ro4-1284 is reduced to saline and no drug control levels. These results suggest a favorable prospect for essential fatty acids in general, and SR-3 in particular, to provide an improved therapeutic option for the clinical management of benign essential blepharospasm.
Mostofsky
D I
DI
Psychopharmacology Laboratory, Department of Psychology, Bar Ilan University, Ramat Gan, Israel. dmostof@bu.edu
Yehuda
S
S
Rabinovitz
S
S
Carasso
R
R
D012369:2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; D000818:Animals; D001764:Blepharospasm / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control*; D004298:Dopamine / Q000172:deficiency / Q000378:metabolism; D004338:Drug Combinations; D005228:Fatty Acids, Essential / Q000627:therapeutic use*; D008042:Linolenic Acids / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014741:Video Recording
D004338:Drug Combinations; D005228:Fatty Acids, Essential; D008042:Linolenic Acids; C112516:SR 3 linolenic acid; D012369:2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; D004298:Dopamine