title: The sera from GM1 ganglioside antibody positive patients with Guillain-Barré syndrome or chronic inflammatory demyelinating polyneuropathy blocks Na+ currents in rat single myelinated nerve fibers.
abstract: OBJECTIVE
  To determine the possible role of anti-GM1 ganglioside antisera from patients with Gullain-Barr*e syndrome (GBS) or chronic inflammatory demyelinating polyneuropathy (CIDP) in the development of nerve dysfunction.
  
  
  METHODS
  The effect of the anti-GM1 antibody positive antisera obtained from 4 GBS patients and 1 CIDP patient on membrane potential and ionic currents in rat single myelinated nerve fibers was investigated using the voltage clamp technique and compared with that of the anti-GM1 negative antisera obtained from 3 healthy controls and 2 GBS patients.
  
  
  RESULTS
  In the presence of active complement, anti-GM1 positive antisera from 5 patients including 4 GBS patients and 1 CIDP patient significantly suppressed Na+ current more than anti-GM1 negative antisera.
  
  
  CONCLUSIONS
  This study supports the notion that anti-GM1 antibody is one of the causative factors of conduction abnormality in GBS patients.
authors.affiliation: Third Department of Medicine, Shiga University of Medical Science, Otsu.
authors.forename: T
authors.initials: T
authors.lastname: Takigawa
authors.forename: H
authors.initials: H
authors.lastname: Yasuda
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: M
authors.initials: M
authors.lastname: Haneda
authors.forename: A
authors.initials: A
authors.lastname: Kashiwagi
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Saida
authors.forename: H
authors.initials: H
authors.lastname: Kitasato
authors.forename: R
authors.initials: R
authors.lastname: Kikkawa
mesh_terms: D000328:Adult; D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000494:pharmacology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000502:physiology; D018408:Patch-Clamp Techniques; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000276:immunology*; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000187:drug effects*
chemical_list: D007106:Immune Sera; D015221:Potassium Channels; D015222:Sodium Channels; D005677:G(M1) Ganglioside; D012964:Sodium