title: Sry-negative XX true hermaphrodite in a Basset hound.
abstract: A true hermaphrodite was diagnosed in a 7-mo.-old Basset hound. The diagnosis was based on the clinical signs, the histology of the gonads and the karyogram. Additionally, the dog was tested for the Y-linked gene Sry, which was negative. The Basset hound presented here is compared to other XX sex reversed animals described in the literature. In man, XX sex reversal is a heterogenous condition. The pathogenesis in Sry-negative individuals is not understood. Thus Sry-negative animals could serve as an animal model of the human disease.
authors.affiliation: Department of Reproduction, University of Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Hubler
authors.forename: B
authors.initials: B
authors.lastname: Hauser
authors.forename: V N
authors.initials: VN
authors.lastname: Meyers-Wallen
authors.forename: S
authors.initials: S
authors.lastname: Arnold
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D012734:Disorders of Sex Development / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery; D004285:Dogs; D005260:Female; D017353:Gene Deletion; D007621:Karyotyping; D009687:Nuclear Proteins; D016133:Polymerase Chain Reaction; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors