The uniqueness of the imprinting mechanism.
An epigenetic imprinting mechanism that is based on a gamete-specific methylation imprint restricts expression of a subset of mammalian genes to one parental chromosome. Recent results suggest that imprints may act only indirectly to induce monoallelic expression of coding genes. Instead, atypical non-coding RNAs appear to be a primary target of the imprints, and their parental-specific repression correlates with parental-specific expression of linked coding genes.
Sleutels
F
F
Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, 1066CX, The Netherlands.
Barlow
D P
DP
Lyle
R
R
D000818:Animals; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D018392:Genomic Imprinting / Q000235:genetics*; D006801:Humans