title: Venlafaxine versus fluoxetine in the treatment of atypical anorectic outpatients: a preliminary study.
abstract: The efficacy of venlafaxine and fluoxetine in the treatment of atypical anorexia nervosa (AN) was compared in a controlled trial. A consecutive series of 24 atypical anorectic females was assigned to either venlafaxine (75 mg/day) or fluoxetine (40 mg/day) plus cognitive-behavioural therapy (CBT). Eating Disorder Examination (EDE12.0D), Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) scores were compared before and after 6 months of treatment. Venlafaxine and fluoxetine determined an increase of body mass index (BMI) and a significant reduction of EDE12.0D and BDI scores; venlafaxine alone reduced STAI scores. It would seem that venlafaxine is as effective as fluoxetine when combined with CBT in the treatment of atypical AN.
authors.affiliation: Department of Neurologic and Psychiatric Sciences, University of Firenze, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Ricca
authors.forename: E
authors.initials: E
authors.lastname: Mannucci
authors.forename: A
authors.initials: A
authors.lastname: Paionni
authors.forename: M
authors.initials: M
authors.lastname: Di Bernardo
authors.forename: M
authors.initials: M
authors.lastname: Cellini
authors.forename: P L
authors.initials: PL
authors.lastname: Cabras
authors.forename: C M
authors.initials: CM
authors.lastname: Rotella
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000188:drug therapy* / Q000523:psychology; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D015897:Comorbidity; D003511:Cyclohexanols / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D010555:Personality Inventory; D000069470:Venlafaxine Hydrochloride
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003511:Cyclohexanols; D005473:Fluoxetine; D000069470:Venlafaxine Hydrochloride