Prolonged QT interval and torsades de pointes caused by the combination of fluconazole and amitriptyline.
Dorsey
S T
ST
Biblo
L A
LA
D000639:Amitriptyline / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D004347:Drug Interactions; D004562:Electrocardiography; D004638:Emergency Treatment; D005260:Female; D015725:Fluconazole / Q000009:adverse effects*; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000175:diagnosis*; D008875:Middle Aged; D013575:Syncope / Q000139:chemically induced* / Q000175:diagnosis*; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis*
D000929:Antidepressive Agents, Tricyclic; D000935:Antifungal Agents; D000639:Amitriptyline; D015725:Fluconazole