title: Quantitative bone scintigraphy. A methodological evaluation in prostate cancer.
abstract: OBJECTIVE
  To evaluate a simple method for quantification of focal activity in bone scintigraphy (BS).
  
  
  METHODS
  The gamma camera was calibrated using a phantom. Quantitative bone scintigraphy (QBS) was performed on 11 men recently diagnosed with prostate cancer (PCa), for whom routine BS showed involvement of the skeleton. Following endocrine therapy for 4 to 8 months, a second QBS was performed. Changes in QBS values were then compared to changes in serum levels of prostate-specific antigen (PSA).
  
  
  RESULTS
  PSA response indicating regression of PCa was accompanied by a decrease in the QBS value in 8 of the 11 patients. The overall mean error of the QBS values was 15%.
  
  
  CONCLUSIONS
  QBS according to this method is a relatively simple procedure that might contribute to objective evaluation of therapeutic effects in skeletal metastases, although its validity must be tested in a larger clinical material.
authors.affiliation: Department of Diagnostic Radiology, Umeå University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Rydh
authors.forename: K R
authors.initials: KR
authors.lastname: Ahlström
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: L
authors.initials: L
authors.lastname: Johansson
authors.forename: J E
authors.initials: JE
authors.lastname: Damber
authors.forename: R
authors.initials: R
authors.lastname: Tomiç
authors.forename: S O
authors.initials: SO
authors.lastname: Hietala
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D018450:Disease Progression; D015902:Gamma Cameras; D006801:Humans; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen