The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice.
The effect of dimethylarsinic acid (DMA) on skin tumorigenesis by UVB irradiation was examined. Hairless mice (Hos: HR-1) irradiated with UVB at a dose of 2 kJ/m(2) twice weekly, were fed with drinking water containing 1000 ppm DMA, a main metabolite of inorganic arsenics, produced more skin tumors than DMA-untreated mice. Histopathological examination revealed that the mouse malignant tumors with severe atypism appeared only in the treatment group of UVB plus 1000 ppm DMA. These positive results point out the importance of dimethylated metabolites of inorganic arsenic in the process of skin carcinogenesis.
Yamanaka
K
K
Nihon University College of Pharmacy, 7-7-1 Narashinodai, Funabashi, Chiba, Japan. yamanaka@pha.nihon-u.ac.jp
Katsumata
K
K
Ikuma
K
K
Hasegawa
A
A
Nakano
M
M
Okada
S
S
D000284:Administration, Oral; D000818:Animals; D002101:Cacodylic Acid / Q000494:pharmacology*; D018450:Disease Progression; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D002101:Cacodylic Acid