Acute ethanol administration and transient ischemia: a behavioral and neuropathological study.
A pressing clinical question is how acute ethanol exposure might alter the outcome of a simultaneous transient ischemic attack (TIA), since ethanol is known to dysregulate key intermediary metabolites post-ischemia. Mongolian gerbils were administered ethanol (1 or 4 g/kg, s.c.) 1 hour before induction of transient ischemia, via bilateral carotid occlusions of 5 minutes duration. A control group was administered isotonic saline and rendered ischemic. All animals were maintained normothermic during the ischemic procedure. Subjects underwent behavioral assay of acquisition to the water maze 7 days after recovery from the surgery, and neuropathological examination 1-month after the ischemic brain insult. There were no behavioral or neuropathological between-group differences suggesting that mechanisms other than adverse ethanol-induced perturbations of ischemic processes predominate in mediating epidemiological findings of elevated stroke morbidity with high ethanol consumption.
McCrea
S
S
Cerebrovascular Ischemia Research Laboratory, University of Saskatchewan, Saskatoon, Canada.
Miyashita
H
H
Wishart
T
T
Ijaz
S
S
Howlett
W
W
Shuaib
A
A
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000473:pathology*; D002492:Central Nervous System Depressants / Q000097:blood / Q000494:pharmacology*; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000473:pathology* / Q000523:psychology* / Q000601:surgery; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol