[Cerebrovascular circulation during blockade of angiotensin receptors].
In experiments on anaesthetized rats, Losartan was found to cause an obvious decrease in the ABP in normotensive rats. The cerebral blood flow differed independence on cerebral vascular resistance and the ABP level. The autoregulation of the cerebral blood flow remained unaltered. In hypertensive rats Losartan caused a significant decrease in the ABP as compared with normotensive rats. A shift of lower limits of the cerebral blood flow autoregulation towards a lower ABP level, was observed.
Adzhienko
L M
LM
Piatigorsk State Pharmaceutical Academy, 357533, Piatigorsk, Kalinin Pr.,1.
D057911:Angiotensin Receptor Antagonists; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006706:Homeostasis; D006977:Hypertension, Renal / Q000503:physiopathology; D019808:Losartan / Q000494:pharmacology; D008297:Male; D051381:Rats
D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents; D019808:Losartan