title: Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
abstract: The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
authors.forename: P
authors.initials: P
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: H
authors.initials: H
authors.lastname: Duan
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: G
authors.initials: G
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: O K
authors.initials: OK
authors.lastname: Kodzhimatov
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006678:HIV / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D003374:Coumarins; D016207:Cytokines