title: [Therapy of primary open-angle glaucoma by oftan-dipivefrin].
abstract: Choice of optimal hypotensive therapy with the minimal side effects remains a serious problem in therapy of glaucoma. The efficacy and safety of oftan-dipivefrin (Sante, Finland) and glaucon (Alcon, USA) are compared in a controlled balanced randomized open parallel study preceded by a period for discharge of the previous drugs. The period of discharge was 7 days, active treatment was administered for 8 weeks. Sixty patients aged 61-69 years were treated. Thirty-one patients were treated by oftan-dipivefrin (group 1) and 29 by glaucon (group 2). In parallel with this, a 1% pilocarpin solution was administered in both groups. The examinations carried out during all consultations included measurements of intraocular pressure before instillations every day at the same time, evaluation of visual acuity, tonography, and study of the central and peripheral visual fields. The time course of hypotensive effects of both drugs showed a sufficient decrease in intraocular pressure in both groups; the effect of oftan-dipivefrin was more pronounced, while glaucon caused the least number of side effects.
authors.forename: E A
authors.initials: EA
authors.lastname: Egorov
authors.forename: V N
authors.initials: VN
authors.lastname: Alekseev
authors.forename: V P
authors.initials: VP
authors.lastname: Erichev
authors.forename: V V
authors.initials: VV
authors.lastname: Usachev
authors.forename: S V
authors.initials: SV
authors.lastname: Simonova
authors.forename: L V
authors.initials: LV
authors.lastname: Iakubova
mesh_terms: D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000627:therapeutic use; D000368:Aged; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D008916:Miotics / Q000008:administration & dosage / Q000627:therapeutic use; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage / Q000627:therapeutic use; D012449:Safety; D016896:Treatment Outcome; D014792:Visual Acuity; D014794:Visual Fields
chemical_list: D000322:Adrenergic Agonists; D008916:Miotics; D009883:Ophthalmic Solutions; D010862:Pilocarpine; C015173:dipivefrin; D004837:Epinephrine