Novel peptidomimetic hematoregulatory compounds.
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
Heerding
D A
DA
Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com
Abruzzese
M
M
Alberts
D
D
Burgess
J
J
Callahan
J F
JF
Huffman
W F
WF
King
A G
AG
LoCastro
S
S
DeMarsh
P
P
Pelus
L M
LM
Takata
J S
JS
Bhatnagar
P K
PK
D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000378:metabolism; D015195:Drug Design; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006133:Growth Substances / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D011955:Receptors, Drug / Q000737:chemistry / Q000187:drug effects
D000596:Amino Acids; D002317:Cardiovascular Agents; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C475895:Cxcl1 protein, mouse; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D011955:Receptors, Drug; D016179:Granulocyte Colony-Stimulating Factor; C086049:SK&F 107647; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor