title: [A new potential promoter region of the human connexin 26 gene].
abstract: OBJECTIVE
  To explain regulatory mechanism of the human connexin 26(Cx26) gene.
  
  
  METHODS
  A DNase-1 hypersensitive 1.6 kb fragment upstream of the 5'-terminus of the Cx26 gene was sequenced and assayed with CAT reporter system.
  
  
  RESULTS
  The Cx26-1.6 kb sequence serves as a powerful promoter.
  
  
  CONCLUSIONS
  The Cx26-1.6 kb fragment contains two GT boxes (centering at-6158 and -6213 bp), and a TATA-less TTAAAA box (-6237/-6232 bp) which is another promoter region of the human Cx26.
authors.affiliation: Cancer Research Institute, Hunan Medical University, Changsha, Hunan, 410078 P.R. China.
authors.forename: B
authors.initials: B
authors.lastname: Peng
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Zhou
authors.forename: Z
authors.initials: Z
authors.lastname: Zeng
authors.forename: G
authors.initials: G
authors.lastname: Li
mesh_terms: D001483:Base Sequence; D015500:Chloramphenicol O-Acetyltransferase / Q000235:genetics; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics*; D004742:Enhancer Elements, Genetic; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic
chemical_list: D017630:Connexins; C000607042:GJB2 protein, human; D000072259:Connexin 26; D015500:Chloramphenicol O-Acetyltransferase