title: Lidocaine patch 5%.
abstract: Lidocaine patch 5% comprises a soft, stretchy adhesive patch (l0 by 14 cm) containing 5% lidocaine (700 mg) for the topical treatment of pain associated with postherpetic neuralgia (PHN). Lidocaine provides analgesic relief by blocking neuronal sodium channels. In clinical trials (conducted over 12 hours to 24 days) involving patients with allodynia associated with PHN, treatment with lidocaine patch 5% resulted in a significant reduction in pain intensity and increased pain relief compared with vehicle patch. Lidocaine patch 5% was associated with few adverse events, the most frequent being mild skin redness or irritation at the application site which occurred with a similar incidence with lidocaine and vehicle patch.
authors.affiliation: Adis International Limited, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz
authors.forename: A M
authors.initials: AM
authors.lastname: Comer
authors.forename: H M
authors.initials: HM
authors.lastname: Lamb
mesh_terms: D000042:Absorption; D000279:Administration, Cutaneous; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006562:Herpes Zoster / Q000150:complications; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D009437:Neuralgia / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy*; D015222:Sodium Channels / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D015222:Sodium Channels; D008012:Lidocaine