[Study on the relationship between intratumor microvessel density and neck metastasis of laryngeal and hypopharyngeal squamous cell carcinomas].
Sixty-one laryngeal and hypopharyngeal squamous cell, carcinoma (LC, HPC) tissue slides were immunochemically stained using LSAB method to study epithelium cells. The results demonstrated that (1) intratumor microvessel density (ITMD) in LC and HPC group was higher than that of the benign group (P < 0.05). ITMD was higher in the subgroup of LC and HPC with positive lymph node positive than that with negative lymph nodes. This result suggest that ITMD is relevant not only to the nature of the tumor, but also to lymph node metastasis. The level of ITMD is an important predictive sign of metastasis. (2) The relationship between ITMD and the clinical staging had no statistic significance (P > 0.05). (3) The analysis on the relationship between ITMD and pathologic differentiation indicated that the level of ITMD raised gradually with the lowering of the pathologic differentiation.
Yu
Z
Z
Beijing Istitute of Otolaryngology.
Wang
T
T
Luan
X
X
D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000556:secondary*; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000098:blood supply / Q000473:pathology*; D007822:Laryngeal Neoplasms / Q000098:blood supply* / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged