The human dendritic cell marker CD83 maps to chromosome 6p23.
The chromosomal localization of the human CD83 gene was determined using somatic cell hybrids, a radiation hybrid mapping panel and FISH analysis on human metaphase chromosomes. PCR-based analysis of a single chromosome hybrid panel identified the presence of the CD83 gene on human chromosome 6 and subsequent analysis of the Genebridge4 radiation panel located the gene between AFMa192wg9 and AFMb322wd1 with a lod score of 9.2. Finally, using FISH analysis the CD83 gene was localized to chromosome 6 band p23.
Berchtold
S
S
Department of Dermatology, University of Erlangen-Nürnberg, Germany.
Jones
T
T
Mühl-Zürbes
P
P
Sheer
D
D
Schuler
G
G
Steinkasserer
A
A
D015703:Antigens, CD; D015415:Biomarkers; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D003713:Dendritic Cells / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics*; D017404:In Situ Hybridization, Fluorescence; D008562:Membrane Glycoproteins / Q000235:genetics*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D000097802:CD83 Antigen
D015703:Antigens, CD; D015415:Biomarkers; D004247:DNA; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D000097802:CD83 Antigen