title: Inhibitory effect of herbal medicines on rotavirus infectivity.
abstract: The inhibitory effect of some traditional herbal medicines on the infectivity of rotavirus, which predominantly occurs in sporadic diarrhea in infants and young children, was investigated. Among the 34 kinds of herbal medicines tested, the fruit of Citrus aurantium had the most potent inhibitory activity on rotavirus infection. The active components of the fruit of Citrus aurantium were neohesperidin and hesperidin. Their 50% inhibitory concentrations were 25 and 10 microM, respectively.
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul, Korea.
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: M J
authors.initials: MJ
authors.lastname: Song
authors.forename: E A
authors.initials: EA
authors.lastname: Bae
authors.forename: M J
authors.initials: MJ
authors.lastname: Han
mesh_terms: D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012401:Rotavirus / Q000187:drug effects* / Q000472:pathogenicity; D014774:Virulence / Q000187:drug effects
chemical_list: D010936:Plant Extracts