title: Experimental basis for cancer prevention by vitamin E.
abstract: Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies (experimental pathology, immunology and molecular biology, synergism, selectivity and safety), in vitro biochemical studies, and human studies (epidemiology and biomarkers, prevention of many pathologic entities other than cancer).
authors.affiliation: Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Massachusetts, USA. gerald_shklar@hms.harvard.edu
authors.forename: G
authors.initials: G
authors.lastname: Shklar
authors.forename: S K
authors.initials: SK
authors.lastname: Oh
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor; D004195:Disease Models, Animal; D016021:Epidemiologic Studies; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D009374:Neoplasms, Experimental / Q000517:prevention & control; D014810:Vitamin E / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D014408:Biomarkers, Tumor; D014810:Vitamin E