title: A particulate pulse-release system and mathematical description with the Maxwell-Stefan theory.
abstract: In this contribution both the development of a multi-particulate delayed release system with release properties dependent on the swelling of an UV crosslinked coating and a mathematical model to describe its release properties are presented. The formulation consists of a water-soluble core coated with a copolymer of methacrylic acid and ethyl acrylate. Incorporating a network of crosslinked pentaerythritol triacrylate decreases the water-solubility of the coating. After immersing the formulation in water the coating will take up water and subsequently swell in such a degree that the diffusion coefficient of water in the coating will increase. This makes the coating permeable to the dissolved components present in the core. The swelling kinetics of the coating are such that the formulation has a pulse-release profile, i.e. a fast release of the contents is obtained after a pre-determined lag-time. Both the coating thickness and the duration of the UV crosslinking time can be used to adjust the lag-time. The experimental results are used to estimate the Maxwell-Stefan diffusion coefficients of water in the coating. The relation between the Maxwell-Stefan diffusion coefficient and the mole fraction of water in the coating differs from results found in the literature. However, the prediction of the release time based on the presented model is in good agreement with the experimental findings.
authors.affiliation: Department of Industrial Pharmacy, University of Groningen, 9713 AV, Groningen, The Netherlands. P.J.A.Hartman.Kok@farm.rug.nl
authors.forename: P J
authors.initials: PJ
authors.lastname: Hartman Kok
authors.forename: P
authors.initials: P
authors.lastname: Vonk
authors.forename: N W
authors.initials: NW
authors.lastname: Kossen
mesh_terms: D000179:Acrylates; D003692:Delayed-Action Preparations; D004058:Diffusion; D008689:Methacrylates; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008962:Models, Theoretical; D010330:Patents as Topic; D011673:Pulsatile Flow
chemical_list: D000179:Acrylates; D003692:Delayed-Action Preparations; D008689:Methacrylates; C040833:ethyl acrylate