[Preventive and therapeutic effects of radix Salviae miltiorrhizae on glycerol-induced acute renal failure in rats].
Three substances obtained from Radix Salviae Miltiorrhizae were administered to rats with acute renal failure (ARF) induced by intramuscular injection of glycerol. The rats treated with the substances had significantly lower serum urea and creatinine levels than the untreated animals. In the treated group, the survival percentage was higher than that in the untreated group. Examination of kidneys showed that the treated group had significantly lighter renal damage than the untreated group. These results suggest that the three substances exert preventive and therapeutic effects on the ARF in rats and the effects are probably the result of adenosine antagonism.
Jin
H
H
Department of Pharmacy, Shenyang Pharmaceutical University.
Wang
A
A
Wang
Y
Y
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005990:Glycerol; D007668:Kidney / Q000473:pathology; D008297:Male; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D018047:Receptors, Purinergic P1 / Q000187:drug effects; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D018047:Receptors, Purinergic P1; D003404:Creatinine; D005990:Glycerol