Some new 1,2,3,4-tetrahydroquinoline derivatives.
Two 1,2,3,4-tetrahydoquinoline-based compounds were synthesized and evaluated for antinociceptive properties. Both compounds displayed no significant analgesic activity and at the higher dose showed no characterized CNS depressant activity.
Ferranti
A
A
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna, Italy.
Giovanninetti
G
G
Piazza
F
F
Romualdi
P
P
Capobianco
A
A
Candeletti
S
S
D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D064729:Neurokinin-1 Receptor Antagonists; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
C408890:2-butyl-1,2,3,4-tetrahydro-5-quinolinol; C408891:2-methyl-1,2,3,4-tetrahydroquinoline-5-methanol; D000700:Analgesics; D064729:Neurokinin-1 Receptor Antagonists; D011804:Quinolines