[Cardiovascular alterations induced by the venom of Lachesis muta (serpentes: Viperidae) and its fibrinogenolitic enzyme].
The fibrinogenolytic activity of Lachesis muta stenophyrs venom was studied. Wistar rats catheterized at carotid artery and jugular vein were inoculated with crude venom or enzyme and changes in arterial pressure, cardiac frequency and electrocardiogram were monitored. The enzyme induced a greater fibrinogen reduction than the crude venom without any cardiovascular or histological alteration. In vitro crude venom coagulated blood whereas the enzyme reduced fibrinogen in 23%. Results suggest the potential use of the fibrinogenolytic enzyme as antithrombotic agent.
Granados-Zúñiga
J
J
Laboratorio Clínico, Hospital San Juan de Dios, San José, Costa Rica.
Aragón-Ortíz
F
F
D000704:Analysis of Variance; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D005340:Fibrinogen / Q000494:pharmacology*; D005342:Fibrinolysis; D006339:Heart Rate / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014757:Viper Venoms / Q000201:enzymology / Q000633:toxicity*; D017819:Viperidae
D014757:Viper Venoms; D005340:Fibrinogen