title: Do blood concentrations of neurone specific enolase and S-100 beta protein reflect cognitive dysfunction after abdominal surgery?ISPOCD Group.
abstract: Neurone specific enolase (NSE) and S-100 beta protein have been used as markers of brain damage. We hypothesized that blood concentrations of NSE and S-100 beta protein reflect cognitive dysfunction after abdominal surgery. We studied 65 elderly patients in whom neuropsychological testing was performed before abdominal surgery, at discharge from hospital and after 3 months. Serum concentrations of NSE and S-100 beta protein were measured before surgery and after 24, 48 and 72 h. Serum concentrations of S-100 beta protein increased significantly while NSE concentrations decreased significantly. The increase in S-100 beta protein concentration after 48 h was significantly greater in patients with delirium. No correlation was found between cognitive dysfunction and S-100 beta protein or NSE concentration. We conclude that blood concentrations of S-100 beta protein increase after abdominal surgery and may be related to postoperative delirium.
authors.affiliation: Department of Anaesthesia, Copenhagen University Hospital, Denmark.
authors.forename: L S
authors.initials: LS
authors.lastname: Rasmussen
authors.forename: M
authors.initials: M
authors.lastname: Christiansen
authors.forename: H
authors.initials: H
authors.lastname: Rasmussen
authors.forename: P A
authors.initials: PA
authors.lastname: Kristensen
authors.forename: J T
authors.initials: JT
authors.lastname: Moller
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000175:diagnosis*; D003693:Delirium / Q000097:blood / Q000175:diagnosis; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009414:Nerve Growth Factors; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011183:Postoperative Complications / Q000175:diagnosis*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
chemical_list: D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase