The cortical vibrissae representation is normal in transgenic mice lacking the 5-HT(1B) receptor.
Recent studies have suggested that 5-HT may modulate thalamocortical development in somatosensory cortex (S-I) of rats and mice, and that the 5-HT(1B) receptor may play a critical role in this process. Analysis of CO-stained sections through lamina IV of S-I in perinatal and adult 5-HT(1B) knockout mice revealed a normal vibrissae-related pattern, indicating that activation of the 5-HT(1B) receptor is not necessary for the normal development of the vibrissae representation in S-I.
Boylan
C B
CB
Department of Anatomy and Neurobiology, Medical College of Ohio, 3035 Arlington Avenue, Toledo, OH, USA. cboylan@mco.edu
Kesterson
K L
KL
Crnko-Hoppenjans
T A
TA
Ke
M
M
Rizk
T
T
Mooney
R D
RD
Rhoades
R W
RW
D000818:Animals; D001923:Brain Chemistry / Q000235:genetics; D003576:Electron Transport Complex IV / Q000032:analysis; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000235:genetics*; D013003:Somatosensory Cortex / Q000737:chemistry* / Q000201:enzymology / Q000254:growth & development*; D014738:Vibrissae / Q000294:innervation*
D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D003576:Electron Transport Complex IV