Biomimetic modeling of copper oxidase reactivity.
Bioinspired copper-model-complexes that react with O(2) provide an opportunity to probe biological reactivity at a small-molecule level of detail. Biological structural information combined with appropriate ligand design has proven sufficient to create Cu:O(2) complexes capable of external substrate oxidation. Most notable developments during the review period are the bioinspired catalysts capable of aerobic alcohol-oxidation. The extension of this oxidative reactivity to other important organic transformations beyond the scope of the inspiring system completes a modeling paradigm.
Mahadevan
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Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Gebbink
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Stack
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D002384:Catalysis; D003300:Copper; D004578:Electron Spin Resonance Spectroscopy; D008956:Models, Chemical; D010088:Oxidoreductases / Q000737:chemistry* / Q000378:metabolism*; D010100:Oxygen
D003300:Copper; D010088:Oxidoreductases; C024748:copper oxidase; D010100:Oxygen