title: IgA-lambda/IgG-kappa biclonal myeloma in which two clones proliferated in individual sites.
abstract: A 72-year-old man was admitted to our hospital because of lumbago and numbness of legs. Tumor invasion at the fourth lumbar vertebra was revealed. Immunohistochemistry using specific antibodies against each heavy and light chain of immunoglobulin revealed that the myeloma cells in bone marrow were all IgA-lambda type whereas they were all positive for IgG-kappa type in a tumor of the fourth lumbar vertebra. These data indicate that the patient had IgG-kappa/IgA-lambda biclonal myeloma. Different phenotypes of M-proteins and distinct proliferating sites for two clones suggest that they may have resulted from two independent transforming events.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical University, Shinjuku-ku.
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Yaguchi
authors.forename: S
authors.initials: S
authors.lastname: Okabe
authors.forename: K
authors.initials: K
authors.lastname: Miyazawa
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
mesh_terms: D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000097:blood* / Q000276:immunology; D007146:Immunoglobulin lambda-Chains / Q000097:blood* / Q000276:immunology; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000293:injuries / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009101:Multiple Myeloma / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D016103:Spinal Fractures / Q000175:diagnosis / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains