title: Extent of surgery for intermediate-risk well-differentiated thyroid cancer.
abstract: BACKGROUND
  Methods of assigning patients with papillary or follicular thyroid cancer (well-differentiated thyroid cancer) to risk groups for the purpose of determining appropriate therapy have been developed. Despite these efforts, the optimal extent of surgery for intermediate-risk patients remains controversial.
  
  
  METHODS
  A retrospective study was conducted of 208 patients with well-differentiated thyroid cancer (DTC) from two institutions. Univariate and multivariate analysis of patient- and tumor-related variables was performed. A regression model was obtained, three risk groups (low, intermediate, and high) were defined, and survival curves were generated.
  
  
  RESULTS
  Prognostic variables were age (P <0.001), distant metastases (P <0.001), tumor size (P <0.001) and an aggressive growth pattern (P = 0.03) by univariate analysis and age (P <0.001) and distant metastases (P <0.001) by multivariate analysis. Tumor size (P = 0.07) was included in the regression model. Total thyroidectomy appeared to provide a survival advantage for intermediate risk patients. High-risk patients treated by lobectomy had a poorer prognosis.
  
  
  CONCLUSIONS
  Total thyroidectomy may provide a survival advantage for intermediate-risk patients with DTC. A prospective randomized trial with 200 such patients is required to confirm this finding.
authors.affiliation: Department of Surgery, University of Alabama at Birmingham School of Medicine, USA.
authors.forename: S
authors.initials: S
authors.lastname: Beenken
authors.forename: D
authors.initials: D
authors.lastname: Roye
authors.forename: H
authors.initials: H
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Sellers
authors.forename: M
authors.initials: M
authors.lastname: Urist
authors.forename: A
authors.initials: A
authors.lastname: Diethelm
authors.forename: H
authors.initials: H
authors.lastname: Goepfert
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012306:Risk; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy