title: Corneal epithelial changes due to adenovirus type 8 infection. A non-contact photomicrographic in vivo study in the human cornea.
abstract: OBJECTIVE
  To investigate corneal epithelial changes in human adenovirus type 8 (Ad8) infection, and compare them with herpes simplex virus type 1 (HSV1) changes.
  
  
  METHODS
  12 patients with Ad8 infection: in 10 verified by tissue culture, in 2 clinically. The corneae were photographed by non-contact photomicrography.
  
  
  RESULTS
  Within the first days the epithelium showed multiple elevations measuring about 20-30 microm in diameter, and from about day 5 large numbers of scattered subsurficial abnormal cells. At the end of the first week larger (about 150-200 microm in diameter) epithelial foci started to appear. No focal ulcerative changes were observed.
  
  
  CONCLUSIONS
  The subsequent stages of Ad8 cytopathic effect are difficult to discern. The primary virus target seems to be the deeper epithelial layers. The damaged cells are probably successively transported toward the surface and desquamated. The etiology of larger focal changes is unclear. The presence (HSV1) or absence (Ad8) of ulcerative changes differentiates these two infections.
authors.affiliation: Department of Ophthalmology, Malmö University Hospital, Sweden.
authors.forename: H M
authors.initials: HM
authors.lastname: Tabery
mesh_terms: D000258:Adenovirus Infections, Human / Q000473:pathology* / Q000821:virology; D000260:Adenoviruses, Human / Q000302:isolation & purification*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003588:Cytopathogenic Effect, Viral; D019573:Epithelium, Corneal / Q000473:pathology* / Q000821:virology; D015828:Eye Infections, Viral / Q000473:pathology* / Q000821:virology; D005260:Female; D018259:Herpesvirus 1, Human; D006801:Humans; D016849:Keratitis, Herpetic / Q000473:pathology / Q000821:virology; D007637:Keratoconjunctivitis / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D010784:Photomicrography; D012189:Retrospective Studies