title: [A two-year follow-up of zidovudine plus lamivudine combined with indinavir in antivival naive HIV-infected patients].
abstract: Efficacy of a 3-drug combination (Zidovudine (AZT) + Lamivudine (3TC) + Indinavir (IDV)) has been evaluated in 17 anti-viral naive patients with HIV infection for 24 months. Our genotypic resistance assay was able to analyze more than 80% of the patients whose viral load (VL) was over 3,000 copies/ml. This therapy was continued in 11 patients (65%) for 24 months. Among them, VL was undetectable (VL < 400 copies/ml) in patients at 24 month (47% by intent-to-treat, 72% by on treatment). Of the 11 patients, a 3TC resistance-related mutantion was detected in only one case. The therapy was discontinued in 6 cases. Main reasons of the discontinuation were side effects. However, if the therapy was switched to other combinations when VL was undetectable, VL remained undetectable in 5 cases at 24 month.
authors.affiliation: AIDS Clinical Center, International Medical Center of Japan.
authors.forename: S
authors.initials: S
authors.lastname: Aizawa
authors.forename: A
authors.initials: A
authors.lastname: Sakai-Hachiya
authors.forename: S
authors.initials: S
authors.lastname: Ida
authors.forename: N
authors.initials: N
authors.lastname: Tachikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: M
authors.initials: M
authors.lastname: Aoki
authors.forename: A
authors.initials: A
authors.lastname: Yasuoka
authors.forename: S
authors.initials: S
authors.lastname: Oka
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D017320:HIV Protease Inhibitors / Q000008:administration & dosage*; D006801:Humans; D019469:Indinavir / Q000008:administration & dosage*; D019259:Lamivudine / Q000008:administration & dosage*; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*; D015215:Zidovudine / Q000008:administration & dosage*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D015215:Zidovudine; D019469:Indinavir