title: Effect of saline irrigation flow rate on temperature profile during cooled radiofrequency ablation
abstract: Introduction: Cooled radiofrequency ablation has been developed clinically for the treatment of ventricular tachycardia. Although clinical studies employ a constant saline flow rate for cooling, we hypothesized that varying the flow rates might optimize the temperature profile at depth.Methods: In excised ovine left ventricle, we compared the temperature profile from a catheter tip electrode thermocouple to those placed at depths of 0.0 mm, 1.0 mm, and 2.0 mm. We compared the following settings: 20 Watts without flow, 20 Watts with 0.3 cc/sec flow, 20 Watts with 0.5 cc/sec flow, and 70 degrees C surface temperature without flow (temperature control).Results: The temperatures decreased from 77.5+/-10.5 degrees C, 91.7+/-6.3 degrees C, 65.5+/-11.8 degrees C, and 52. 5+/-11.8 degrees C at 20 W without saline irrigation at the tip, 0.0 mm, 1.0 mm, and 2.0 mm, respectively, to 33.0+/-1.4 degrees C*, 63. 4+/-7.0 degrees C*, 57.1+/-5.8 degrees C*, 49.9+/-5.8 degrees C+ at 20 W with 0.5 ml/sec flow (*P<0.01, +P=0.09). The lesion volumes were 79.6 mm(3) for 20 W without flow, 64.1 mm(3) for 20 W with 0.3 ml/sec flow, 47.5 mm(3) for 20 W with 0.5 ml/sec flow, and 28.6 mm(3) for temperature control.Conclusions: We conclude that 1) the temperature profile greatly depends upon the rate of saline flow for cooling; 2) at high flow rates, the 0.0 mm and 1.0 mm temperatures are similar; 3) even at high irrigation rates, lesion size is greater than for temperature control; 4) the tip temperature significantly underestimates the surface temperature and improved methods of measuring temperature are needed.
authors.affiliation: Cardiac Arrhythmia Service, New England Medical Center, Boston, MA.
authors.initials: WS
authors.lastname: Wong
authors.initials: BA
authors.lastname: VanderBrink
authors.initials: RE
authors.lastname: Riley
authors.initials: M
authors.lastname: Pomeranz
authors.initials: MS
authors.lastname: Link
authors.initials: MK
authors.lastname: Homoud
authors.initials: III
authors.lastname: Estes
authors.initials: PJ
authors.lastname: Wang