Determination of glomerular filtration rate using a dual-detector gamma camera and the geometric mean of renal activity: correlation with the Tc-99m DTPA plasma clearance method.
OBJECTIVE
In this study, the authors studied the use of a dual-detector gamma camera to measure the glomerular filtration rate (GFR).


METHODS
Thirty-three patients with a wide range of renal function participated in this study. The GFR was measured using a dual-detector gamma camera by calculating the geometric mean of activity from each kidney and using an outline background. These results were compared with the GFR estimates obtained from Tc-99m DTPA plasma clearance using a multiple blood sample method.


RESULTS
Correlation was excellent between GFR estimated using the dual-detector gamma camera and GFR measured using the plasma clearance of Tc-99m DTPA with multiple blood samples (r = 0.89). The correlation was especially strong in children younger than 13 years (r = 0.94).


CONCLUSIONS
Measuring the GFR using a dual-detector gamma camera and calculating the geometric mean of renal activity yields relatively accurate results.
Delpassand
E S
ES
Department of Nuclear Medicine, The University of Texas, MD Anderson Cancer Center, Houston 77030, USA. edelpassand@di.mdacc.tmc.edu
Homayoon
K
K
Madden
T
T
Mathai
M
M
Podoloff
D A
DA
D000328:Adult; D002648:Child; D015902:Gamma Cameras; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D011866:Radioisotope Renography; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate
D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate