title: Nitric oxide-mediated mucus hypersecretion protects the stomach of ovariectomized rats.
abstract: The actions of ovariectomy on nitric oxide synthase (assessed by the citrullin assay), mucus secretion (assessed by the Alcyan blue technique) and ulcerogenic response (indomethacin (30 mg kg(-1), s.c. , 4 h) or cysteamine (400 mg kg(-1), s.c., 24 h)) were studied in the female rat stomach. Ovariectomy increased nitric oxide synthase and mucus secretion, and decreased the severity of lesions, effects reversed by the nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME, 10 mg kg(-1), s.c., 4 h before measurements). Therefore, estrogen-deficiency protects the gastric mucosa by nitric oxide (NO)-mediated mucus hypersecretion.
authors.affiliation: First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary. laszlof@koki.hu
authors.forename: E
authors.initials: E
authors.lastname: Morschl
authors.forename: I
authors.initials: I
authors.lastname: Bretus
authors.forename: I
authors.initials: I
authors.lastname: Pávó
authors.forename: L
authors.initials: L
authors.lastname: Topa
authors.forename: Z
authors.initials: Z
authors.lastname: Weiszhar
authors.forename: F
authors.initials: F
authors.lastname: László
mesh_terms: D000818:Animals; D004967:Estrogens / Q000172:deficiency*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D009093:Mucus / Q000378:metabolism*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000096:biosynthesis; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004967:Estrogens; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester