[Effect of lipoprotein lipase gene polymorphism on plasma lipid levels,BMI and subcutaneous fat distribution in simple obesity children].
OBJECTIVE
To assess the effect of Hind III DNA polymorphism in the lipoprotein lipase(LPL) gene on plasma lipid levels, body mass index(BMI) and subcutaneous fat distribution in simple obesity children.


METHODS
The polymerase chain reaction(PCR) and restriction fragment length polymorphism(RFLP) techniques were used to detect the Hind III-LPL genotypes in 92 children with simple obesity. The levels of the plasma lipid, plasma lipoproteins, BMI and skinfold thickness at three measuring points(biceps, subscapular and abdominal wall) were also measured.


RESULTS
The levels of TG, TC, LDL-C, Apo B, BMI, biceps and subscapular skinfold thickness with the average value of three measuring points in the obesity children with H(+) H(+)-LPL genotype were significantly higher than those in the obesity children with H(+) H(-)-LPL genotype.


CONCLUSIONS
LPL-Hind III polymorphism may modify the levels of plasma lipid. plasma lipoproteins and BMI in children with simple obesity, and in the mean while it may affect the distribution of subcutaneous fat.
Guo
X
X
Department of Pediatrics, Nanjing Medical University, Nanjing, Jiangsu, 210029 P.R. China.
Chen
R
R
Mo
B
B
Liu
Q
Q
D015992:Body Mass Index; D002648:Child; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D012885:Skinfold Thickness
D008055:Lipids; D008071:Lipoprotein Lipase