title: Intravascular low-power red laser light as an adjunct to coronary stent implantation: initial clinical experience.
abstract: Low-power red laser light (LPRLL) irradiation enhances endothelial cell growth in vitro and in vivo and reduces restenosis in animal models. The present study reports the preliminary clinical experience in our center. Eighty-one patients were treated with LPRLL, 30 mW/1 min, for in-stent restenosis (n = 27), elective stenting for recurrent restenosis (n = 16), and stenting for treatment of a suboptimal PTCA result (n = 38). All interventions were successful and no major adverse events due to LPRLL therapy were observed. At follow-up, 12 patients (14.8%) underwent an early control coronarogram due to target vessel restenosis. At 6 months, another 20 patients showed a significant restenosis of the target vessel. Preliminary clinical evaluation demonstrates that LPRLL is feasible and safe. The preliminary results suggest that LPRLL results in a decrease of in-stent restenosis when used during primary stenting.
authors.affiliation: Department of Cardiology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: I K
authors.initials: IK
authors.lastname: De Scheerder
authors.forename: K
authors.initials: K
authors.lastname: Wang
authors.forename: X R
authors.initials: XR
authors.lastname: Zhou
authors.forename: M
authors.initials: M
authors.lastname: Szilard
authors.forename: E
authors.initials: E
authors.lastname: Verbeken
authors.forename: Q B
authors.initials: QB
authors.lastname: Ping
authors.forename: H
authors.initials: H
authors.lastname: Yanming
authors.forename: H
authors.initials: H
authors.lastname: Jianhua
authors.forename: F
authors.initials: F
authors.lastname: Van de Warf
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000295:instrumentation*; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000628:therapy*; D004867:Equipment Design; D005240:Feasibility Studies; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D012008:Recurrence; D019233:Retreatment; D015607:Stents