title: Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood.
abstract: Acute basophilic leukemia is an uncommon form of acute leukemia, rarely occurring as a de novo disease. We describe a case of de novo acute basophilic leukemia occurring in a 47-year-old man who presented with abnormal liver function tests in the absence of leukemic infiltration of the liver. We postulate that this presentation occurred as a consequence of pathophysiological features of the malignant basophilic blast cells.
authors.affiliation: Department of Anatomical Pathology, Canberra Hospital, Garran, ACT, Australia.
authors.forename: R A
authors.initials: RA
authors.lastname: Scolyer
authors.forename: M
authors.initials: M
authors.lastname: Brun
authors.forename: J
authors.initials: J
authors.lastname: D'Rozario
authors.forename: M
authors.initials: M
authors.lastname: Webb
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000473:pathology; D003561:Cytarabine / Q000627:therapeutic use; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D016130:Immunophenotyping; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D017254:Leukemic Infiltration / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology*
chemical_list: D003561:Cytarabine; D015255:Idarubicin