The administration to Indonesians of monosodium L-glutamate in Indonesian foods: an assessment of adverse reactions in a randomized double-blind, crossover, placebo-controlled study.
Monosodium L-glutamate (MSG) has been suggested to cause postprandial symptoms after the ingestion of Chinese or oriental meals. Therefore, we examined whether such symptoms could be elicited in Indonesians ingesting levels of MSG typically found in Indonesian cuisine. Healthy volunteers (n = 52) were treated with capsules of placebo or MSG (1.5 and 3.0 g/person) as part of a standardized Indonesian breakfast. The study used a rigorous, randomized, double-blind, crossover design. The occurrence of symptoms after MSG ingestion did not differ from that after consumption of the placebo.
Prawirohardjono
W
W
Department of Pharmacology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia.
Dwiprahasto
I
I
Astuti
I
I
Hadiwandowo
S
S
Kristin
E
E
Muhammad
M
M
Kelly
M F
MF
D000293:Adolescent; D000328:Adult; D000368:Aged; D003296:Cooking; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007214:Indonesia; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010919:Placebos / Q000009:adverse effects; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000009:adverse effects*
D005503:Food Additives; D010919:Placebos; D012970:Sodium Glutamate