Effect of San-Ao-Tang on immediate and late airway response and leukocyte infiltration in asthmatic guinea pigs.
San-Ao-Tang (SAT), a traditional Chinese medicines, has been used to treat patients with the bronchial asthma for several centuries. However, the therapeutic mechanisms of this Chinese medicine are still far from clear. To understand the mechanism of antiasthmatic property of SAT, a guinea pig model of allergic asthma was used to investigate the effects of SAT on Dermatophagoides pteronyssinus-induced immediate and late asthmatic responses and airway inflammation. Our results showed that administration of SAT (10 g/kg) extracts significantly inhibited the antigen induced immediate asthmatic responses (IAR) in actively sensitized guinea pig. Examination of bronchoalveolar lavage fluid (BALF) revealed that SAT significantly inhibited the increase in neutrophil in the airway at 1, 2, 4, 6, 8 hr after antigen challenge. Histopathologic examination showed SAT suppressed the neutrophil infiltration into lung tissue. These results suggest that the antiasthmatic effect of SAT be mainly due to its bronchodilator effect and its ability to inhibit the neutrophil into the airway. The precise mechanism of action of SAT in asthma remains to be elucidated.
Kao
S T
ST
Department of Immunology and Cellular Physiology, School of Post Baccalaureate Chinese Medicine, and China Medical College Hospital, Taichung, Taiwan, ROC.
Yeh
T J
TJ
Hsieh
C C
CC
Yeh
F T
FT
Lin
J G
JG
D000403:Airway Resistance / Q000187:drug effects; D000485:Allergens / Q000276:immunology; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology; D008297:Male; D008925:Mites / Q000276:immunology; D020556:Neutrophil Infiltration / Q000187:drug effects*; D012137:Respiratory System / Q000473:pathology*; D013997:Time Factors
D000485:Allergens; D018927:Anti-Asthmatic Agents; D004365:Drugs, Chinese Herbal; C411354:san-ao-tang