Naloxone decreases tolerance to hypotensive, hypovolemic stress healthy humans.
OBJECTIVE
In animal studies, naloxone, an opioid receptor antagonist, improves tolerance to hemorrhagic shock. The purpose of this study was to determine whether naloxone would augment tolerance to hypotensive hypovolemic stress (lower body negative pressure [LBNP]) in healthy human males.


METHODS
This study was a repeated measures design.


METHODS
The experiments were conducted in a laboratory setting.


METHODS
Eight healthy male subjects were tested. The subjects' ages were 30 +/- 4.0 yrs, height = 177 +/- 7.0 cm, and weight = 75.5 +/- 3.5 kg (mean +/- SEM).


METHODS
Subjects underwent two LBNP exposures terminated by the onset of vasodepression. At each of the exposures, using a double-blind procedure, the subjects received an intravenous injection of either saline placebo or naloxone in a dosage totaling 0.4 mg/kg.
Lightfoot
J T
JT
Department of Health Promotion and Kinesiology, University of North Carolina, Charlotte 28223, USA. jtlightf@email.uncc.edu
Katz
L
L
DeBate
K
K
D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure; D004311:Double-Blind Method; D005542:Forearm / Q000098:blood supply; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D020896:Hypovolemia / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011446:Prospective Studies; D012039:Regional Blood Flow; D012771:Shock, Hemorrhagic / Q000188:drug therapy
D009292:Narcotic Antagonists; D009270:Naloxone