title: Severe type II Gaucher disease with ichthyosis, arthrogryposis and neuronal apoptosis: molecular and pathological analyses.
abstract: Severe infantile Gaucher disease associated with ichthyosis and neonatal death is a rare subgroup of Type II Gaucher disease. This group of infants has little, if any, detectable beta-glucocerebrosidase activity, and prior genetic analyses have been limited in detecting the mutations responsible for this phenotype. We document an Hispanic infant succumbing with arthrogryposis and collodion membrane covering the skin who had no detectable beta-glucocerebrosidase activity in tissue samples and who was homozygous for a rare recombinant allele, RecNciI. Microscopic evaluation demonstrated accumulation of Gaucher cells in visceral organs and extensive loss of neurons in the anterior horns, brainstem, and cortex of the nervous system. The apoptosis of neuronal cells from the anterior horns and brainstem are a reasonable explanation for the arthrogryposis and neonatal death, respectively.
authors.affiliation: Department of Pathology, Children's Hospital and Medical Center, University of Washington, Seattle, Washington, USA. lfinn@chmc.org
authors.forename: L S
authors.initials: LS
authors.lastname: Finn
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: S H
authors.initials: SH
authors.lastname: Chen
authors.forename: C R
authors.initials: CR
authors.lastname: Scott
mesh_terms: D017209:Apoptosis; D001176:Arthrogryposis / Q000150:complications / Q000473:pathology*; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D017809:Fatal Outcome; D005260:Female; D005776:Gaucher Disease / Q000150:complications / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D005962:Glucosylceramidase / Q000032:analysis / Q000235:genetics; D006801:Humans; D016113:Ichthyosiform Erythroderma, Congenital / Q000150:complications / Q000473:pathology*; D007231:Infant, Newborn; D008103:Liver Cirrhosis / Q000473:pathology; D009474:Neurons / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology / Q000648:ultrastructure
chemical_list: D005962:Glucosylceramidase