Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.
Ferguson
D M
DM
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA.
Kramer
S
S
Metzger
T G
TG
Law
P Y
PY
Portoghese
P S
PS
D000595:Amino Acid Sequence; D002460:Cell Line; D004399:Dynorphins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011869:Radioligand Assay; D017473:Receptors, Opioid, kappa / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; C026843:dynorphin (1-13); D004399:Dynorphins