title: Usefulness of hypotension during dobutamine echocardiography in predicting perioperative cardiac events.
abstract: This study was undertaken to determine the prognostic significance of hypotension induced during preoperative dobutamine stress echocardiography (DSE) before vascular and noncardiac thoracic surgery. Wall motion abnormality during DSE predicts perioperative risk. Although hypotension during DSE has not been shown to correlate with the presence or severity of coronary artery disease, its significance in perioperative risk assessment is unknown. We retrospectively studied 300 patients who had DSE within 6 months of noncardiac surgery. Perioperative events including death, myocardial infarction, ischemia, and arrhythmias were recorded. Odds ratios with 95% confidence intervals were used to examine the association between clinical and echocardiographic variables and perioperative events. A hypotensive response during DSE was seen in 85 patients (28%). Forty-eight patients (16%) had 54 perioperative complications including 4 cardiac-related deaths, 10 myocardial infarctions, 12 myocardial ischemic events, and 28 arrhythmias. Hypotension during DSE was predictive of the combined end point of perioperative cardiac mortality, myocardial infarction, and ischemia (odds ratio 4.04, 95% confidence interval 1.72 to 9.51). In a multivariate logistic regression model, hypotension during DSE remained a significant predictor (odds ratio 4.10, p<0.01). DSE-related hypotension was predictive of perioperative cardiac events and therefore may have a role in risk stratification before vascular or noncardiac thoracic surgery.
authors.affiliation: Department of Emergency Medicine, University of Michigan Medical Center, Ann Arbor, USA.
authors.forename: S M
authors.initials: SM
authors.lastname: Day
authors.forename: J G
authors.initials: JG
authors.lastname: Younger
authors.forename: D
authors.initials: D
authors.lastname: Karavite
authors.forename: D S
authors.initials: DS
authors.lastname: Bach
authors.forename: W F
authors.initials: WF
authors.lastname: Armstrong
authors.forename: K A
authors.initials: KA
authors.lastname: Eagle
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002316:Cardiotonic Agents / Q000008:administration & dosage; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D004280:Dobutamine / Q000008:administration & dosage; D004452:Echocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011379:Prognosis; D012189:Retrospective Studies; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine