Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention.
Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of morbidity and mortality in Western societies. Current therapies, such as reduction of plasma cholesterol, significantly reduce, but do not come close to eliminating, the complications of ASCVD. Therefore, novel therapeutic approaches to the prevention of acute coronary events and progression of atherosclerosis are still needed. The complex metabolism of high density lipoproteins represents an attractive potential target for therapeutic intervention. Here, we will discuss those components of the high density lipoprotein metabolism and lipid transport pathways that are potential preventative or therapeutic targets for ASCVD.
Rader
D J
DJ
University of Pennsylvania Medical Center, 614 BRBII/III 421 Curie Blvd., Philadelphia, PA 19104, USA. rader@mail.med.upenn.edu
Maugeais
C
C
D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D018955:CD36 Antigens / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D053480:Cholesterol Ester Transfer Proteins; D005796:Genes; D006023:Glycoproteins; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008565:Membrane Proteins; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000235:genetics; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D018528:ATP-Binding Cassette Transporters; D018955:CD36 Antigens; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008071:Lipoprotein Lipase