Actions and interactions of the IGF system in Alzheimer's disease: review and hypotheses.
Insulin-like growth factors (IGF) are pleiotrophic polypeptides affecting all aspects of growth and development. The IGF system, including ligands, receptors, binding proteins and proteases is also involved in pathophysiological conditions, such as cancer and degenerative conditions. In this review, the actions and interactions of the IGF system as it relates to Alzheimer's disease will be investigated.
Lackey
B R
BR
Endocrine Physiology Laboratory, Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA. blackey@clemson.edu
Gray
S L
SL
Henricks
D M
DM
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007328:Insulin / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism* / Q000502:physiology*
D007328:Insulin; D019253:Proto-Oncogene Proteins c-bcl-2; D013002:Somatomedins; D020169:Caspases