Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitors.
Nonpeptidyl aryloxymethylphosphonates were prepared and evaluated as protein tyrosine phosphatase inhibitors. The results suggest that aryloxymethylphosphonates are effective nonhydrolyzable phosphotyrosine surrogates and provide further insight into the molecular mechanisms by which phosphate mimics inhibit phosphatase function.
Ibrahimi
O A
OA
Department of Chemistry, New York University, New York, 10003, USA.
Wu
L
L
Zhao
K
K
Zhang
Z Y
ZY
D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D009943:Organophosphorus Compounds; D017027:Protein Tyrosine Phosphatases