title: [A trial of the use of aekol in preventing psychoautonomic disorders].
abstract: Autonomic dysfunction in chronic emotional stress is well documented. The aim of this study was to analyze the effects of natural antioxidant vitamin E (aekol). Twenty persons (16 women and 4 men, mean age 38 +/- 4 years) who reported recent occurrence of emotional stress were examined before and after a 4-week treatment with aekol (5 ml twice a day). Heart rate variability (taking into account very low-frequency (VLF, 0.003-0.04 Hz), low-frequency (LF, 0.04-0.15 Hz), and high-frequency (HF, 0.15-0.40 Hz) components) was computed from the power spectra (5-min epochs) of the EKG recorded in the patients in supine position. After the treatment, the HF power of the heart rate variability (an index of cardiac parasympathetic activity) increased (p < 0.05), whereas the VLF power (an index of the cerebral sympathetic activity) decreased (p < 0.01). The decrease in the VLF was accompanied by a reduction of anxiety level (p < 0.01). According to our hypothesis, the absolute and relative power of the VLF can be used as an index of anxiety or cerebral sympathetic activity, which significantly decreases after the aekol treatment.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: M G
authors.initials: MG
authors.lastname: Aĭrapetiants
authors.forename: N B
authors.initials: NB
authors.lastname: Khaspekova
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001342:Autonomic Nervous System Diseases / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D011603:Psychophysiology; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology / Q000523:psychology; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*; D014812:Vitamin K / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D014801:Vitamin A; D014812:Vitamin K; C059630:vitamin A, vitamin E, vitamin K3 drug combination; D014810:Vitamin E