[Isolation of highly active strain producing the antistaphylococcal antibiotic batumin].
The use of chemical and UV-induced mutageneses allowed us to increase the biosynthetic activity of the strain capable of producing new antistaphylococcal antibiotic, batumin. The strain of Pseudomonas batumici N17 producing 87-100 mg batumin per liter culture liquid was selected. Its activity was 3.5-5 times higher than the activity of the most potent natural strain. P. batumici N17 was shown to be stable in relation to the synthesis of batumin.
Smirnov
V V
VV
Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Churkina
L N
LN
Perepnikhatka
V I
VI
Mukvich
N S
NS
Garagulia
A D
AD
Kiprianova
E A
EA
Kravets
A N
AN
Dovzhenko
S A
SA
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D016296:Mutagenesis; D009930:Organic Chemicals; D011549:Pseudomonas / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D013210:Staphylococcus / Q000187:drug effects*; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D009930:Organic Chemicals; C088306:batumin