title: Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3',5'-methanephosphonates.
abstract: [formula: see text] A method for a large-scale synthesis of stereodefined oligo(nucleoside 3',5'-methanephosphonates) has been developed, based on transient 3'-O protection, which allows for the conversion of the protecting chirally defined methanephosphonanilidate group, located at the 3' end of a stereoregular oligomer, into diastereomerically pure "oligomeric building blocks" for stereospecific coupling with the 5'-OH group of another oligonucleotide.
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódz, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Pyzowski
authors.forename: L A
authors.initials: LA
authors.lastname: Wozniak
authors.forename: W J
authors.initials: WJ
authors.lastname: Stec
mesh_terms: D007202:Indicators and Reagents; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D013936:Thymidine