title: Replication and recombination intersect.
abstract: A bacterial housekeeping function, which requires both recombination and replication enzymes, has been identified that re-establishes inactivated replication forks under normal growth conditions. Some long-tract gene-conversion events initiated by double-strand breaks in yeast and mammalian cells can be attributed to recombination-directed DNA replication. Double-strand break repair in yeast has been shown to require both leading- and lagging-strand DNA synthesis. These observations suggest that the recombination and replication machinery cooperate to maintain genomic integrity.
authors.affiliation: Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. k-marians@ski.mskcc.org
authors.forename: K J
authors.initials: KJ
authors.lastname: Marians
mesh_terms: D000818:Animals; D004261:DNA Replication / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D011995:Recombination, Genetic
chemical_list: D004269:DNA, Bacterial