Low molecular weight dextran attenuates increase in extravascular lung water caused by ARDS.
We studied the effect of low molecular weight dextran (mean molecular weight 40,000, Dextran 40; LMD) on the accumulation of extravascular lung water (EVLW), and also on hemodynamics and blood gases, in the oleic acid (OA)-injured lung in pentobarbital anesthetized rats. Starting just before the OA injection (0.01 mL/kg via femoral vein), 10% LMD in lactated Ringer's solution was infused throughout the experiment (5 mL/kg/h) instead of lactated Ringer's solution. OA caused acute lung injury leading to decreased oxygenation (PaO2: 87 +/- 11 mmHg versus control group 128 +/- 11) and an increased permeability of the alveolar-capillary membrane, as shown by increases in EVLW (4.89 +/- 0.54 versus control group 4.07 +/- 0.14), and albumin leakage (0.043 +/- 0.015 versus control group 0.010 +/- 0.004). LMD protected against the increase in EVLW (4.14 +/- 0.10) and the hypoxemia (112 +/- 19 mmHg), but it did not reduce the albumin leakage into the alveolar space (0.052 +/- 0.009). These data suggest that LMD may limit the fluid accumulation that is secondary to OA-induced lung injury.
Yahagi
N
N
Department of Pathology, National Cardiovascular Center, Suita, Osaka, Japan.
Matsui
J
J
Matsui
S
S
Amakata
Y
Y
Kumon
K
K
Ueda-Ishibashi
H
H
D000418:Albumins / Q000032:analysis; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use*; D001784:Blood Gas Analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D015633:Extravascular Lung Water / Q000737:chemistry / Q000187:drug effects*; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D019301:Oleic Acid; D009929:Organ Size; D010952:Plasma Substitutes / Q000494:pharmacology / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology*
D000418:Albumins; D000925:Anticoagulants; D003911:Dextrans; D010952:Plasma Substitutes; D019301:Oleic Acid