title: Reduction of contrast material dose and artifacts by a saline flush using a double power injector in helical CT of the thorax.
abstract: OBJECTIVE
  Our objective was to evaluate a combined method of contrast material bolus followed by saline solution flush for thoracic helical CT and statistical comparison with a uniphasic injection protocol.
  
  
  METHODS
  Fifty patients underwent helical CT of the thorax using 60 ml of contrast material (370 mg I/ml) followed by flushing with 30 ml of physiologic saline solution. These 50 patients had been examined before using our previous protocol, 75 ml of the same contrast material without a subsequent saline solution. Mean attenuation values for both protocols were measured in the superior vena cava, the pulmonary trunk, and the ascending aorta. Image artifacts and mediastinal and hilar depiction were graded and compared.
  
  
  RESULTS
  Mean attenuation values in the superior vena cava were considerably higher in the regimen without saline solution flush (459 H versus 352 H) and in the pulmonary trunk and the ascending aorta were almost identical for both protocols. Injection of saline solution diminished surrounding artifacts (p = 0.001). Grading results for the evaluation of mediastinal and hilar structures were not significantly different in the two protocols (p = 0.564).
  
  
  CONCLUSIONS
  Injection of contrast material followed by a saline solution bolus using a double power injector when performing thoracic helical CT allows a 20% reduction of contrast material volume to 60 ml with a similar degree of enhancement. In addition, perivenous artifacts in the superior vena cava are significantly reduced.
authors.affiliation: Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Haage
authors.forename: T
authors.initials: T
authors.lastname: Schmitz-Rode
authors.forename: D
authors.initials: D
authors.lastname: Hübner
authors.forename: W
authors.initials: W
authors.lastname: Piroth
authors.forename: R W
authors.initials: RW
authors.lastname: Günther
mesh_terms: D000328:Adult; D000368:Aged; D016477:Artifacts; D003287:Contrast Media / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic / Q000379:methods*; D012965:Sodium Chloride; D007507:Therapeutic Irrigation; D013899:Thoracic Neoplasms / Q000601:surgery*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D012965:Sodium Chloride