Spectrophotometry assay of imipramine and desipramine using ammonium metavanadate and its application to pharmaceutical preparations.
Simple and sensitive method for determination of imipramine and desipramine is reported. The procedure is based on the oxidation of the drugs by ammonium metavanadate. Linear calibration graphs were obtained in the concentration range 0.6-40 microg ml(-1) of imipramine and 0.7-35 microg ml(-1) of desipramine with a relative standard deviation (RSD) less than 0.5%. The method was applied to the determination of the drugs in pharmaceutical preparations and compared favourably with independent official methods.
Misiuk
W
W
Institute of Chemistry, University of Bialystok, Poland.
D000929:Antidepressive Agents, Tricyclic / Q000032:analysis*; D003891:Desipramine / Q000032:analysis*; D007099:Imipramine / Q000032:analysis*; D007202:Indicators and Reagents; D007452:Iodates; D007501:Iron / Q000737:chemistry; D016877:Oxidants; D019999:Pharmaceutical Solutions; D011192:Potassium Dichromate / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets; D013696:Temperature; D014638:Vanadates
D000929:Antidepressive Agents, Tricyclic; D007202:Indicators and Reagents; D007452:Iodates; D016877:Oxidants; D019999:Pharmaceutical Solutions; D013607:Tablets; D014638:Vanadates; D007501:Iron; C101036:ammonium metavanadate; D007099:Imipramine; D011192:Potassium Dichromate; D003891:Desipramine