title: Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.
abstract: The synthesis of a series of new antitumour agents, the benzothiazole substituted quinol ethers and esters, is reported via the hypervalent iodine mediated oxidation of hydroxylated 2-phenylbenzothiazoles. The products were found to be active in vitro against human colon and breast cancer cell lines with IC50 values in the nanomolar range.
authors.affiliation: Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, UK.
authors.forename: G
authors.initials: G
authors.lastname: Wells
authors.forename: T D
authors.initials: TD
authors.lastname: Bradshaw
authors.forename: P
authors.initials: P
authors.lastname: Diana
authors.forename: A
authors.initials: A
authors.lastname: Seaton
authors.forename: D F
authors.initials: DF
authors.lastname: Shi
authors.forename: A D
authors.initials: AD
authors.lastname: Westwell
authors.forename: M F
authors.initials: MF
authors.lastname: Stevens
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000494:pharmacology; D010084:Oxidation-Reduction; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006873:Hydroquinones; D013844:Thiazoles