title: A phytochemical investigation of Alchornea latifolia.
abstract: A phytochemical investigation of the chloroform leaf extract of Alchornea latifolia has been undertaken. Along with the triterpenoids taraxerone, friedelin, epifriedelinol, and taraxerol, the plant also contains seco-3,4-friedelin (dihydroputranjivic acid) (1) and seco-3,4-taraxerone (2). These A-ring-opened triterpenoids show in vitro cytotoxic activity against Hep-G2 and A-431 human cancer cell lines and are potent inhibitors of topoisomerase II.
authors.affiliation: Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA. wsetzer@matsci.uah.edu
authors.forename: W N
authors.initials: WN
authors.lastname: Setzer
authors.forename: X
authors.initials: X
authors.lastname: Shen
authors.forename: R B
authors.initials: RB
authors.lastname: Bates
authors.forename: J R
authors.initials: JR
authors.lastname: Burns
authors.forename: K J
authors.initials: KJ
authors.lastname: McClure
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.forename: D M
authors.initials: DM
authors.lastname: Moriarity
authors.forename: R O
authors.initials: RO
authors.lastname: Lawton
mesh_terms: D019665:Euphorbiaceae; D006801:Humans; D016488:Medicine, African Traditional; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves; D010946:Plants, Medicinal; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000094042:Lupanes
chemical_list: D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; C060796:friedelin; D000094042:Lupanes; C009379:taraxerone