title: Age, dental infections, and coronary heart disease.
abstract: Epidemiological and intervention studies have suggested that infections are risk factors for coronary heart disease (CHD). Dental infections have appeared as cardiovascular risk factors in cross-sectional and in follow-up studies, and the association has been independent of the "classic" coronary risk factors. This case-control study aimed at detailed assessment of the dental pathology found in various CHD categories (including elderly patients). Altogether, 85 patients with proven coronary heart disease and 53 random controls, matched for sex, age, geographic area, and socio-economic status, were compared with regard to dental status, assessed blindly with four separate scores, and to the "classic" coronary risk factors (seven of the controls had CHD, and they were not included in the analyses). The dental indices were higher among CHD patients than in the controls, but, contrary to previous studies, the differences were not significant (between the CHD patients and their matched controls or among the different CHD categories). This result could not be explained by potential confounding factors. The participants in the present study were older and had more often undergone recent dental treatment in comparison with subjects in our earlier studies. Age correlated with the severity of dental infections only in the random controls but not in the coronary patients who, although young, already had high dental scores. We believe that the higher age of the participants in the present study is the most likely reason for the results. Other possible explanations include an age-related selection bias among older CHD patients, and the fact that those participating in studies like this may have better general health and thus also less severe dental infections. Thus, the role of dental infections as a coronary risk factor varies according to the characteristics of the population studied.
authors.affiliation: Dept of Medicine, Helsinki University Central Hospital, Finland. kimmo.mattila.km@bayer.fi
authors.forename: K J
authors.initials: KJ
authors.lastname: Mattila
authors.forename: S
authors.initials: S
authors.lastname: Asikainen
authors.forename: J
authors.initials: J
authors.lastname: Wolf
authors.forename: H
authors.initials: H
authors.lastname: Jousimies-Somer
authors.forename: V
authors.initials: V
authors.lastname: Valtonen
authors.forename: M
authors.initials: M
authors.lastname: Nieminen
mesh_terms: D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000145:classification / Q000150:complications*; D003430:Cross-Sectional Studies; D003729:Dental Care; D003731:Dental Caries / Q000145:classification / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D016017:Odds Ratio; D010510:Periodontal Diseases / Q000145:classification / Q000150:complications*; D010512:Periodontal Index; D012307:Risk Factors; D015983:Selection Bias; D012737:Sex Factors; D016037:Single-Blind Method; D012923:Social Class