title: Determinants of quality of life at first presentation with schizophrenia.
abstract: BACKGROUND
  Quality of life (QOL) has gained importance as a global measure of social and clinical outcome in schizophrenia.
  
  
  OBJECTIVE
  To identify the clinical correlates of QOL at the time of first presentation with schizophrenia.
  
  
  METHODS
  Over two years, consecutive first-episode psychosis patients presenting to a catchment area psychiatric service underwent validated clinical assessments of premorbid adjustment, illness duration, symptoms and QOL.
  
  
  RESULTS
  At presentation, subjects already had a diminished QOL. Although independent of gender and age at onset of psychosis, QOL was influenced by premorbid adjustment, duration of untreated psychosis and symptoms.
  
  
  CONCLUSIONS
  Reducing the duration of untreated psychosis may have a beneficial effect on the subsequent QOL of patients presenting with schizophrenia. First-episode patients with a protracted duration of untreated psychosis or impaired premorbid adjustment may warrant specific treatment interventions to prevent the development of secondary handicaps.
authors.affiliation: Family Centre, Blackrock, Co. Dublin, Republic of Ireland.
authors.forename: S
authors.initials: S
authors.lastname: Browne
authors.forename: M
authors.initials: M
authors.lastname: Clarke
authors.forename: M
authors.initials: M
authors.lastname: Gervin
authors.forename: J L
authors.initials: JL
authors.lastname: Waddington
authors.forename: C
authors.initials: C
authors.lastname: Larkin
authors.forename: E
authors.initials: E
authors.lastname: O'Callaghan
mesh_terms: D000328:Adult; D017668:Age of Onset; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011581:Psychological Tests; D011788:Quality of Life; D012044:Regression Analysis; D012559:Schizophrenia / Q000175:diagnosis* / Q000628:therapy; D012565:Schizophrenic Psychology; D013997:Time Factors