title: Heterogeneity of dermal deposition of eosinophil granule major basic protein in acute lesions of atopic dermatitis.
abstract: Deposition of eosinophil granule major basic protein (MBP) often occurs in acute and chronic lesions of atopic dermatitis, but it is not clear what the factors may be that are related to the MBP deposition in some skin lesions of the disease. The purpose of this study was to determine whether a personal or family history of respiratory atopy is related to the intensity of MBP deposition in acute lesions. We immunohistochemically stained biopsy specimens from acute, non-oozing indurated erythematous lesions of atopic dermatitis with BMK-13, a monoclonal antibody which recognizes MBP. The subjects were 40 adult patients with atopic dermatitis. Of the 40 patients, 22 had a personal history of respiratory atopy, 8 had a family history of respiratory atopy, and 10 had neither a personal nor a family history of respiratory atopy. Deposition of MBP was observed in the specimens from 24 (60%) of the 40 patients examined. Furthermore, there were great individual differences in the intensity of MBP deposition. A strong MBP deposition was often seen in specimens from patients with atopic dermatitis who had a personal or family history of respiratory atopy, but was absent in specimens from those patients with atopic dermatitis who had neither a personal nor a family history of respiratory atopy. We conclude that a strong MBP deposition seems to occur in acute lesions of those patients with atopic dermatitis who have a predisposition to respiratory atopy.
authors.affiliation: Department of Dermatology, Shiga University of Medical Science, Seta, Otsu, Japan. omoto@belle.shiga-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Omoto
authors.forename: L H
authors.initials: LH
authors.lastname: Gu
authors.forename: H
authors.initials: H
authors.lastname: Sugiura
authors.forename: M
authors.initials: M
authors.lastname: Uehara
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D003876:Dermatitis, Atopic / Q000378:metabolism*; D047091:Eosinophil Granule Proteins; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D012260:Ribonucleases; D012867:Skin / Q000378:metabolism*
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases