title: Central motor conduction to lower limb after transcranial magnetic stimulation in spinocerebellar ataxia type 2 (SCA2).
abstract: OBJECTIVE
  To evaluate central motor conduction to lower limbs in spinocerebellar ataxia type 2 (SCA2).
  
  
  METHODS
  Transcranial magnetic stimulation was performed to study the corticospinal tracts of 18 patients with SCA2.
  
  
  RESULTS
  Central motor conduction time (CMCT) to lower limbs and thresholds were abnormal in 8 patients (44%); CMCT and thresholds were significantly correlated with disease duration and disability.
  
  
  CONCLUSIONS
  Corticospinal tract involvement is more frequent than previously reported in SCA2. Prolonged CMCT and increased threshold should not be used to differentiate between various type of autosomal dominant cerebellar ataxia. Similar to that reported in Friedreich's ataxia, we suggest that examining central motor conduction to the lower limbs may assist in evaluating the progressive steps of neurodegeneration in SCA2.
authors.affiliation: Istituto di Scienze Neurologiche, Università di Catania, Viale A. Doria 6, 95125, Catania, Italy.
authors.forename: D A
authors.initials: DA
authors.lastname: Restivo
authors.forename: S
authors.initials: S
authors.lastname: Giuffrida
authors.forename: G
authors.initials: G
authors.lastname: Rapisarda
authors.forename: A
authors.initials: A
authors.lastname: Antonuzzo
authors.forename: R
authors.initials: R
authors.lastname: Saponara
authors.forename: A
authors.initials: A
authors.lastname: Reggio
authors.forename: A
authors.initials: A
authors.lastname: Trovato Salinaro
authors.forename: R
authors.initials: R
authors.lastname: Raffaele
authors.forename: E
authors.initials: E
authors.lastname: Domina
authors.forename: A
authors.initials: A
authors.lastname: Trovato
authors.forename: D F
authors.initials: DF
authors.lastname: Condorelli
authors.forename: G
authors.initials: G
authors.lastname: Pennisi
mesh_terms: D000328:Adult; D000368:Aged; D003711:Demyelinating Diseases / Q000503:physiopathology; D004558:Electric Stimulation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007395:Interneurons / Q000502:physiology; D007866:Leg / Q000294:innervation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009431:Neural Conduction / Q000502:physiology*; D011712:Pyramidal Tracts / Q000166:cytology / Q000503:physiopathology*; D020754:Spinocerebellar Ataxias / Q000175:diagnosis* / Q000503:physiopathology*; D050781:Transcranial Magnetic Stimulation