title: Antibody-mediated insulin resistance treated by cessation of insulin administration.
abstract: A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 microU/ml, but a high titer of total insulin (about 3,000 microU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.
authors.affiliation: The Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo.
authors.forename: K
authors.initials: K
authors.lastname: Hara
authors.forename: K
authors.initials: K
authors.lastname: Tobe
authors.forename: Y
authors.initials: Y
authors.lastname: Uchigata
authors.forename: M
authors.initials: M
authors.lastname: Nakazono
authors.forename: K
authors.initials: K
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Terauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Akanuma
authors.forename: S
authors.initials: S
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000276:immunology; D007328:Insulin / Q000008:administration & dosage* / Q000276:immunology; D007330:Insulin Antibodies / Q000097:blood* / Q000276:immunology; D007333:Insulin Resistance / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D007330:Insulin Antibodies