title: A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins.
abstract: The Bacillus subtilis genome encodes seven homologues of the small multidrug resistance (SMR) family of drug efflux pumps. Six of these homologues are paired in three distinct operons, and coexpression in Escherichia coli of one such operon, ykkCD, but not expression of either ykkC or ykkD alone, gives rise to a broad specificity, multidrug-resistant phenotype including resistance to cationic, anionic, and neutral drugs.
authors.affiliation: Department of Biology, University of California at San Diego, La Jolla, California 92093-0116, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Jack
authors.forename: M L
authors.initials: ML
authors.lastname: Storms
authors.forename: J H
authors.initials: JH
authors.lastname: Tchieu
authors.forename: I T
authors.initials: IT
authors.lastname: Paulsen
authors.forename: M H
authors.initials: MH
authors.lastname: Saier
mesh_terms: D017920:Antiporters / Q000235:genetics / Q000378:metabolism*; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics*; D001693:Biological Transport, Active / Q000235:genetics; D004352:Drug Resistance, Microbial / Q000235:genetics*; D018432:Drug Resistance, Multiple / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009876:Operon; D010641:Phenotype; D017386:Sequence Homology, Amino Acid
chemical_list: D017920:Antiporters; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; C075436:EmrE protein, E coli