Why are growth factors important in oligodendrocyte physiology?
Recent studies in chicken, rodents and transgenic mice have provided new insight on the nature of factors essential to oligodendrocyte development. Here we first review how sonic hedgehog (shh) graded signalling induces emergence of oligodendrocytes in the embryonic spinal cord from birds to man. We then discuss the way in which thyroid hormone successively signals different thyroid receptors to control fate determination, growth and differentiation in the oligodendrocyte lineage. Platelet-derived growth factor (PDGF) is a potent regulator of oligodendrocyte progenitor (OP) migration and proliferation, while insulin-like growth factor 1 (IGF-1) acts both on neurons and myelin-forming cells to promote myelination. The balance between OP proliferation and differentiation appears to be controlled by different sets of growth factors locally synthesized in the central nervous system (CNS) as well as glutamate. In experimental models of multiple sclerosis (MS), the neuregulin isoform glial growth factor 2, IGF-1 and some neurotrophins can promote remyelination after an episode of inflammatory demyelination. A future challenge is to determine how to induce multipotential neural precursors to generate migratory OP and enhance the remyelination process in the adult CNS.
Dubois-Dalcq
M
M
Unité de Neurovirologie et Régénération du Système Nerveux, Institut Pasteur, Paris, France.
Murray
K
K
D000818:Animals; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D009186:Myelin Sheath / Q000502:physiology; D009414:Nerve Growth Factors / Q000502:physiology; D009836:Oligodendroglia / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology; D013234:Stem Cells / Q000502:physiology; D013963:Thyroid Hormones / Q000502:physiology
D006133:Growth Substances; D009414:Nerve Growth Factors; D013963:Thyroid Hormones