Pharmacokinetics of indomethacin in poultry.
Indomethacin (INDO) is a nonsteroidal antiinflammatory drug widely used since the 1970s. The pharmacokinetic behavior of INDO (2 mg/kg) has been studied after intravenous (i.v.) and oral administration to broiler chickens. After i.v. administration, a first fast distribution phase and a later and slower elimination phase were observed. The elimination half-life and mean residence time (MRT) obtained were 1.0 hr and 0.8 hr, respectively. After oral administration, a flip-flop phenomenon was observed giving an elimination half-life and MRT approximately three times and six times higher, respectively, than the i.v. administration. The plasma concentrations after oral administration were sustained during 8-10 hr, giving an antinflammatory cover over the dose producing 50% of maximal effect during this time period.
Cristòfol
C
C
Departament de Farmacologia i de Terapèutica, Facultat de Veterinària, UAB, Bellaterra, Spain.
Valladares
J E
JE
Martí
G
G
Arboix
M
M
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002645:Chickens / Q000378:metabolism*; D006207:Half-Life; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007275:Injections, Intravenous
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin