title: Reduced F-18 fluorodeoxyglucose uptake within marrow after external beam radiation.
abstract: OBJECTIVE
  The authors examined the delayed effects of external beam radiation on the metabolism of intravertebral marrow cavities.
  
  
  METHODS
  Two neurologically normal persons who had completed a full course of external beam radiotherapy for squamous cell carcinoma of the head and neck had positron emission tomography (PET) scans with F-18 fluorodeoxyglucose (FDG) to identify residual neoplasm.
  
  
  RESULTS
  Abnormally low uptake of F-18 FDG was noted within the central marrow cavities of the cervical vertebral bodies in both cases.
  
  
  CONCLUSIONS
  Diminished metabolic activity within irradiated marrow can be revealed by F-18 FDG PET imaging techniques. Further correlative MRI PET studies are needed to determine if this postradiation phenomenon is related to fatty infiltration of the marrow cavity.
authors.affiliation: Department of Neurology, University of Missouri School of Medicine, Columbia 65212, USA. MeyerMA@health.missouri.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Meyer
authors.forename: C A
authors.initials: CO
authors.lastname: Nathan
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000528:radiation effects*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000532:radiotherapy; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy; D006801:Humans; D008297:Male; D018365:Neoplasm, Residual; D019275:Radiopharmaceuticals; D011882:Radiotherapy, High-Energy; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18