[Clinical significance of galactose oxidase-Schiff reaction in the detection of carcinoma and precancerous lesions of large intestine].
OBJECTIVE
To study the clinical value of galactose oxidase-Schiff (GO-S) reaction to test carcinoma and precancerous lesions of large intestine.


METHODS
127 patients who had symptoms and signs of digestive tract diseases and 10 normal controls were studied, with their samples of rectum mucus smears stained. The histological sections of 73 cases of carcinoma and precancerous lesions of large intestine were stained with GO-S reaction.


RESULTS
The positive rates of GO-S reaction in carcinoma and precancerous lesions of large intestine were over 80%. The specificity and sensitivity of GO-S reaction to detect carcinoma and precancerous lesions of large intestine were 98% and 86%, respectively. The positive predictive value was 90%.


CONCLUSIONS
GO-S reaction, being satisfactory and sensitive marker of carcinoma and precancerous lesions of large intestine, can be used for screening and general survey of these lesions.
Qin
J
J
Department of Pathology, Wulumuqi Railway Central Hospital.
Zhang
Q
Q
Fang
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D005692:Galactose Oxidase; D006801:Humans; D008297:Male; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000378:metabolism; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C016467:Thomsen-Friedenreich antigen; D005692:Galactose Oxidase