Biosynthesis of depudecin, a metabolite of Nimbya scirpicola.
Feeding experiments of labeled acetates to Nimbya scirpicola proved the carbon origin of the straight-chain polyketide, depudecin. Differential hydrogen exchange of the 2H label originating from 2H labeled acetate along the polyketide chain occurred. In particular, the deuterium of an epoxide methine at C-3 was lost to a substantial extent in the formation of depudecin.
Tanaka
M
M
Plant Protection Research Laboratory, Japan Tobacco Inc., Yokohama, Kanagawa. masayasu.tanaka@ims.jti.co.jp
Fujimori
T
T
Nabeta
K
K
D000466:Alkadienes / Q000737:chemistry / Q000378:metabolism*; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism*; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000254:growth & development / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy
D000466:Alkadienes; D004852:Epoxy Compounds; D005233:Fatty Alcohols; C072251:depudecin