[Disorders of hormone reception and intracellular signaling in hypertension].
This article discusses the disruption taking place due to hypertension in regulatory cell systems. These can either participate in development of the pathology or, on the opposite, provide compensation, be part of the mechanism that brings to normal the functional and metabolic state of cells under this disease. Data on increased level of Ca2+, higher reactivity of cells in relation of Ca2+ mobilizing hormones, alkalinisation of cytoplasma, activation of phosphoinozitide metabolism and stimulation of proteinkinaze C evidence in favour of the suggestion that these disruptions of regulatory cell systems are the material basis of the phenomenon of "structural support" to arterial hypertension.
Chazov
E I
EI
Russian Cardiology Research and Production Complex, RF Health Ministry, Moscow.
Men'shikov
M Iu
MIu
Tkachuk
V A
VA
D000818:Animals; D002118:Calcium / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D006728:Hormones; D011956:Receptors, Cell Surface; D002118:Calcium