Anti-herpes virus activity of Solanum steroidal glycosides.
Since some Solanum-genus plants have traditionally been used for anti-cancer and anti-herpes agents from olden times, we examined anti-herpes simplex virus type 1 (HSV-1) activity of typical steroidal glycosides with the frameworks of spirostane (including nuatigenin glycoside), furostane, solasodane, tomatidane and ergostane (including dimer) obtained from Solanum plants. Among these steroidal glycosides, the spirostanol glycosides were most effective. An inclination was observed for the potency of activity to decrease in the order of spirostane, tomatidane, ergostane, solasodane, nuatigenin type, dimer of ergostane and furostane. It was also suggested that the activity depends on the kind of oligosacchride moiety.
Ikeda
T
T
Laboratory of Natural Medicines, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Ando
J
J
Miyazono
A
A
Zhu
X H
XH
Tsumagari
H
H
Nohara
T
T
Yokomizo
K
K
Uyeda
M
M
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D006027:Glycosides; D013256:Steroids