title: Transposition of the great arteries, pulmonary atresia, and multiple ventricular septal defects associated with multiple cardiac rhabdomyomas in a case of tuberous sclerosis.
abstract: Multiple cardiac rhabdomyomas are frequently associated with tuberous sclerosis. However, very few cardiac malformations have been described with tuberous sclerosis. We report an unusual case of tuberous sclerosis with cerebral and renal lesions associated with dextrotransposition of the great arteries, pulmonary atresia, patent ductus arteriosus, multiple ventricular septal defects, and parachute mitral valve deformity. After reviewing other cases of congenital heart diseases associated with tuberous sclerosis, emphasis is made on the potential influence of multiple rhabdomyomas developing very early during fetal life on final cardiac structures.
authors.affiliation: Department of Cardiology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Jiang
authors.forename: A
authors.initials: A
authors.lastname: Pircova
authors.forename: N
authors.initials: N
authors.lastname: Sekarski
authors.forename: I
authors.initials: I
authors.lastname: Hack
authors.forename: R
authors.initials: R
authors.lastname: Laurini
authors.forename: R
authors.initials: R
authors.lastname: Janzer
authors.forename: M
authors.initials: M
authors.lastname: Payot
mesh_terms: D000015:Abnormalities, Multiple; D017809:Fatal Outcome; D005260:Female; D006330:Heart Defects, Congenital / Q000150:complications* / Q000000981:diagnostic imaging; D006338:Heart Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D006345:Heart Septal Defects, Ventricular / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D018633:Pulmonary Atresia / Q000000981:diagnostic imaging; D012207:Rhabdomyoma / Q000150:complications* / Q000000981:diagnostic imaging; D014188:Transposition of Great Vessels / Q000000981:diagnostic imaging; D014402:Tuberous Sclerosis / Q000150:complications*; D014463:Ultrasonography