title: Statistical comparison of high-shear versus low-shear granulation using a common formulation.
abstract: Experimental combinations from the ranges assigned to the independent factors were studied using both a low-shear (planetary) mixer and a high-shear mixer for granulation. The independent factors studied were X1 calcium phosphate/mannitol ratio, X2 pregelatinized starch, X3 magnesium stearate, X4 mixer type, and X5 compression pressure. To optimize the tablet properties fully, the experimental range was varied from -2 to +2 experimental units, with the exception of X4, which was assigned -1 for the planetary mixer and +1 for the high-shear mixer. Drug dissolution did not seem to be affected by mixer type, but tablet hardness was affected by mixer type.
authors.affiliation: Merck Research Laboratories, West Point, PA 19486, USA.
authors.forename: P K
authors.initials: PK
authors.lastname: Shiromani
authors.forename: J
authors.initials: J
authors.lastname: Clair
mesh_terms: D002626:Chemistry, Pharmaceutical; D008432:Mathematical Computing; D012995:Solubility; D013607:Tablets
chemical_list: D013607:Tablets