Virucidal and chlamydicidal activities of eye drops with povidone-iodine liposome complex.
Povidone-iodine (PVP-I) is a broad-spectrum microbicide with in vitro activity against bacteria, viruses, fungi and protozoans. A 5% solution of PVP-I proved to be highly effective in ophthalmic surgery for the prophylaxis of endophthalmitis. For the antiseptic treatment of eye infections a novel application form of PVP-I has been developed by using a PVP-I liposome complex which demonstrated an excellent antimicrobial efficacy. In this study it could be shown that the novel liposomal formulations containing 2.5 or 5% PVP-I were as active as the aqueous solution against herpes simplex virus type 1, adenovirus type 8, coxsackievirus A9 and Chlamydia trachomatis in cell culture referring to equal PVP-I concentrations. Long-term cytotoxicity experiments demonstrated a moderate cytotoxicity for both formulations with a better tolerability of the liposomal PVP-I formulation compared with the aqueous solution. There is no evidence for a genotoxic activity of these agents.
Wutzler
P
P
Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany. wutzler@zmkh.ef.uni-jena.de
Sauerbrei
A
A
Klöcking
R
R
Burkhardt
J
J
Schacke
M
M
Thust
R
R
Fleischer
W
W
Reimer
K
K
D000260:Adenoviruses, Human / Q000187:drug effects*; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects*; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D004770:Enterovirus / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008081:Liposomes; D008297:Male; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D011206:Povidone-Iodine / Q000494:pharmacology*; D011817:Rabbits; D014709:Vero Cells
D000891:Anti-Infective Agents, Local; D008081:Liposomes; D009883:Ophthalmic Solutions; D011206:Povidone-Iodine