title: Prevalence and clinical significance of anti-phospholipid antibodies in multiple sclerosis: a study of 89 patients.
abstract: The prevalence of serum anti-phospholipid antibodies (aPL) was evaluated in multiple sclerosis (MS) patients to search for a possible association with a distinct form of the disease. Anti-cardiolipin antibodies (Ab) (aCL) and anti-beta 2 glycoprotein I Ab (abeta2GPI) were measured together with antinuclear Ab (ANA), anti-double-stranded DNA Ab (anti-ds DNA) and anti-myelin Ab in 89 patients. Twenty-nine (32.6%) patients had serum aPL, 19xaCL (15 of the IgG and four of the IgM isotype), 14 abeta2GPI (two IgG and 12 IgM) (four of these patients had both Ab). Prevalence of aCL correlated with that of ANA, which were positive in 52 patients (P=0. 005) and with anti-myelin Ab detected in two patients (P=0.046) but not with that of anti-ds DNA (mostly of the IgM class) detected in 28% of case by ELISA. No correlation could be found between aPL and age, sex, duration of the disease from diagnosis, category of MS, clinical course, clinical symptoms, serum IgM levels nor atypical lesions by magnetic resonance imaging. Hence, aCL and abeta2GPI are neither rare in MS nor associated with a specific clinical form of the disease and they cannot be a diagnosis exclusion criteria.
authors.affiliation: Laboratory of Immunology, CNRS ESA 6031, Poitiers, France.
authors.forename: V
authors.initials: V
authors.lastname: Roussel
authors.forename: F
authors.initials: F
authors.lastname: Yi
authors.forename: M O
authors.initials: MO
authors.lastname: Jauberteau
authors.forename: C
authors.initials: C
authors.lastname: Couderq
authors.forename: C
authors.initials: C
authors.lastname: Lacombe
authors.forename: V
authors.initials: V
authors.lastname: Michelet
authors.forename: R
authors.initials: R
authors.lastname: Gil
authors.forename: P
authors.initials: P
authors.lastname: Couratier
authors.forename: J M
authors.initials: JM
authors.lastname: Vallat
authors.forename: J L
authors.initials: JL
authors.lastname: Preud'homme
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood / Q000276:immunology; D000974:Antibodies, Antinuclear / Q000097:blood / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000097:blood / Q000276:immunology*; D005260:Female; D005602:France / Q000453:epidemiology; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D009186:Myelin Sheath / Q000276:immunology; D015995:Prevalence; D053482:beta 2-Glycoprotein I
chemical_list: D017153:Antibodies, Anticardiolipin; D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I