title: [Acute poisoning with industrial products].
abstract: Poisonings with industrial products represent approximately 7% of the cases reported to the poison centres. Ingestion of petroleum distillates induces irritation of the gastrointestinal tract, central nervous system depression and aspiration pneumonitis which may be severe; treatment is mainly supportive. Ethylene and diethylene glycol poisonings produce central nervous system depression, anion gap metabolic acidosis, osmolar gap and acute tubular necrosis; in severe cases, hypocalcaemia, cerebral oedema and heart failure may be observed; treatment often associates supportive measures, haemodialysis and administration of competitive inhibitors of alcohol dehydrogenase (ethanol or 4-methylpyrazole). Glycol ethers induce central nervous system depression and metabolic acidosis; in addition, ethylene glycol monobutyl ether produces haemolysis; monomethyl and monoethyl ethers are responsible for bone marrow and lymphoid organ toxicity, they adversely affect spermatogenesis and are teratogens.
authors.affiliation: Centre anti-poisons de Paris, Hôpital Fernand-Widal.
authors.forename: R
authors.initials: R
authors.lastname: Garnier
mesh_terms: D000062:Accidents, Occupational; D000208:Acute Disease; D000473:Alkanes / Q000506:poisoning; D000475:Alkenes / Q000506:poisoning; D005026:Ethylene Glycols / Q000506:poisoning*; D005260:Female; D006801:Humans; D006839:Hydrocarbons, Acyclic / Q000506:poisoning*; D006841:Hydrocarbons, Aromatic / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000175:diagnosis / Q000628:therapy; D019946:Propylene Glycol / Q000506:poisoning*
chemical_list: D000473:Alkanes; D000475:Alkenes; D005026:Ethylene Glycols; D006839:Hydrocarbons, Acyclic; D006841:Hydrocarbons, Aromatic; C013484:diethylene glycol; D019946:Propylene Glycol