[Pharmacokinetics of Caulis Erycibes injection in rabbits].
The pharmacokinetics of single i.m. doses of Caulis Erycibes injection in ten rabbits was studied. The concentration of scopoletin-one of the effective components in Caulis Erycibes injection in serum was analyzed by high performance liquid chromotography with fluorescence monitor. In eight of ten rabbits a second peak was found on the serum concentration-time curve. The absorption of scopoletin was quick with Tmax 1 = 8.08 +/- 3.88 min, Cmax 1 = 145.45 +/- 47.65 ng/ml. The time to the second peak concentration (Tmax 2) was 2.45 +/- 1.79 h, Cmax 2 = 48.66 +/- 41.66 ng/ml. The other parameters were as follows: Ke = 0.56 +/- 0.37 h-1, T1/2 = 1.81 +/- 1.14 h, MRT = 156.61 +/- 98.41, CL/F = 220.54 +/- 109.35 ml/min, Vd/F = 30.49 +/- 19.34 L, AUC = 8.52 +/- 5.15 micrograms.min/ml. The reason for the appearance of double peaks was discussed.
Zhou
Y
Y
First Teaching Hospital, Guangxi Medical University, Nanning.
Li
M
M
Zhao
S
S
D000818:Animals; D018501:Antirheumatic Agents / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D007273:Injections, Intramuscular; D019684:Magnoliopsida; D008297:Male; D011817:Rabbits; D012603:Scopoletin / Q000493:pharmacokinetics*
D018501:Antirheumatic Agents; D004365:Drugs, Chinese Herbal; D012603:Scopoletin