Antiinfluenza virus effect of extracts from marine algae and invertebrates.
Sixty products, derived from marine organisms, typical of the Bulgarian Black Sea coast, were examined for inhibitory activity on the reproduction of influenza viruses in tissue cultures. The antiviral effect was investigated by the reduction of virus infectivity. Using representative strains of influenza virus it was shown that apparently the inhibitory effect was strain-specific. The most effective products were further studied in fertile hen's eggs and in experimental influenza infection in white mice.
Serkedjieva
J
J
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia. viroljul@bas.bg
Konaklieva
M
M
Dimitrova-Konaklieva
S
S
Ivanova
V
V
Stefanov
K
K
Popov
S
S
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002642:Chick Embryo; D056890:Eukaryota / Q000737:chemistry*; D006385:Hemagglutination Inhibition Tests; D009980:Influenza A virus / Q000187:drug effects*; D007448:Invertebrates; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*; D012623:Seawater; D013045:Species Specificity; D014020:Tissue Extracts / Q000494:pharmacology*
D000998:Antiviral Agents; D010936:Plant Extracts; D014020:Tissue Extracts