A possible cross-talk of retinoic acid- and TPA-driven myeloid differentiation pathways.
Retinoic acid (RA) and phorbol esters are important regulators of cellular proliferation and differentiation processes which are capable of arresting growth and inducing differentiation of various leukemic cells. We have studied and compared the effects of these agents on the line of v-myb oncogene-transformed chicken monoblasts BM2. We found that although there are differences in the differentiation kinetics and cell cycle stop points, the differentiation pathways induced by RA and phorbol esters seem to be significantly interconnected.
Zemanová
K
K
Department of Genetics and Molecular Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
Smarda
J
J
D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002461:Cell Line, Transformed; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D020239:Receptor Cross-Talk; D018168:Receptors, Retinoic Acid / Q000187:drug effects / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
D018168:Receptors, Retinoic Acid; D014212:Tretinoin; D013755:Tetradecanoylphorbol Acetate