title: Successful bone marrow transplantation in an adult patient with reactive hemophagocytic syndrome associated with myelodysplastic syndrome.
abstract: We report an adult case of reactive hemophagocytic syndrome (RHS) associated with myelodysplastic syndrome (MDS) who received emergency bone marrow transplantation (BMT). Despite methylprednisolone pulse therapy, high-dose gamma-globulin, and chemotherapy containing etoposide, the pancytopenia progressed. After informed consent, the patient underwent syngeneic BMT using melphalan as the conditioning regimen. The patient has been well without relapse of RHS and MDS for more than 2 years after BMT. This result suggests that the above strategy, including BMT, should be considered for the treatment of adult RHS associated with hematological malignancy.
authors.affiliation: Fifth Department of Internal Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan. gd2t-krsn@asahi-net.or.jp
authors.forename: T
authors.initials: T
authors.lastname: Karasuno
authors.forename: H
authors.initials: H
authors.lastname: Teshima
authors.forename: A
authors.initials: A
authors.lastname: Hiraoka
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Masaoka
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D018572:Disease-Free Survival; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000628:therapy*; D010198:Pancytopenia; D014185:Transplantation, Isogeneic
chemical_list: D008558:Melphalan