title: Parallel synthesis of a series of subtype-selective NMDA receptor antagonists.
abstract: A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for the NR1A/2B receptor subtype.
authors.affiliation: Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA. tracy.gregory@wl.com
authors.forename: T F
authors.initials: TF
authors.lastname: Gregory
authors.forename: J L
authors.initials: JL
authors.lastname: Wright
authors.forename: L D
authors.initials: LD
authors.lastname: Wise
authors.forename: L T
authors.initials: LT
authors.lastname: Meltzer
authors.forename: K A
authors.initials: KA
authors.lastname: Serpa
authors.forename: C S
authors.initials: CS
authors.lastname: Konkoy
authors.forename: E R
authors.initials: ER
authors.lastname: Whittemore
authors.forename: R M
authors.initials: RM
authors.lastname: Woodward
mesh_terms: D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D016627:Oxidopamine; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013563:Sympathectomy, Chemical; D013565:Sympatholytics
chemical_list: D018691:Excitatory Amino Acid Antagonists; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; D013565:Sympatholytics; D016627:Oxidopamine