title: Vasoseal hemostasis following coronary interventions with abciximab.
abstract: Femoral arteriotomy management using a collagen vascular hemostasis device (VasoSeal, Datascope Corporation, Montvale, New Jersey) was studied in 50 consecutive patients following interventional coronary procedures performed with abciximab (ReoPro, Eli Lilly and Company, Indianapolis, Indiana). Low-dose weight-adjusted or no heparin was employed. The first 25 patients were permitted to sit up after 6 hours with ambulation the following day. The second 25 patients were allowed to sit up after 1 hour and ambulate after 6 hours. Despite early activity and ambulation, there were no hemorrhagic complications including hematoma, pseudoaneurysm, blood transfusion, or surgical repair. Hemoglobin and platelet counts remained stable overnight prior to discharge. This pilot study demonstrates the potential efficacy of VasoSeal in achieving early sheath removal and ambulation in patients undergoing interventional procedures using ReoPro.
authors.affiliation: Easton Hospital, Easton, PA 18042, USA.
authors.forename: L
authors.initials: L
authors.lastname: Lunney
authors.forename: K
authors.initials: K
authors.lastname: Karim
authors.forename: T
authors.initials: T
authors.lastname: Little
mesh_terms: D000077284:Abciximab; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D000911:Antibodies, Monoclonal / Q000009:adverse effects; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000379:methods; D003094:Collagen / Q000627:therapeutic use; D004434:Early Ambulation; D004864:Equipment and Supplies; D005260:Female; D005263:Femoral Artery / Q000293:injuries; D006489:Hemostatic Techniques / Q000295:instrumentation*; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016602:Needlestick Injuries / Q000209:etiology / Q000628:therapy; D010865:Pilot Projects; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D006490:Hemostatics; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D003094:Collagen; D000077284:Abciximab