A role for leptin in the antiaging action of dietary restriction: a hypothesis.
A neuroendocrine signal may play an important role in the antiaging action of dietary restriction (DR). Recent studies have suggested that falling leptin levels by starvation activate the hypothalamic-pituitary-adrenal axis, and suppress gonadal, somatotropic, and thyroid axes as a response for adaptation. Accumulated evidence indicates that similar hormonal changes also occur in DR rodents. In this article, we advance that a reduction in plasma leptin levels in DR rodents might be a critical neuroendocrine modulator in the antiaging action of dietary restriction.
Shimokawa
I
I
Department of Pathology, Nagasaki University School of Medicine, Nagasaki City, Japan. shimo@net.nagasaki-u.ac.jp
Higami
Y
Y
D000375:Aging / Q000502:physiology*; D000818:Animals; D004032:Diet; D006801:Humans; D020738:Leptin / Q000502:physiology*; D008962:Models, Theoretical; D009490:Neurosecretory Systems / Q000503:physiopathology; D013217:Starvation / Q000503:physiopathology
D020738:Leptin