A new MICA allele with ten alanine residues in the exon 5 microsatellite.
The MICA and MICB genes code for protein products that have structural similarities to major histocompatibility complex (MHC) class I genes. These genes are upregulated by heat stress. They have been shown to interact with a common receptor (NKG2D/DAP10) on gammadelta T cells, CD8+ T cells and natural killer (NK) cells. The MICA gene has an expressed microsatellite, GCT, within the exon 5 which encodes for alanine. So far, four different repetitions of this short tandem have been reported. Also one non-synonymous, one synonymous substitution and a 1-bp insertion within this region have also been described. An association of Behcet's disease with the microsatellite A9 has been reported. Here we report a novel allele with 10 GCT repetitions (A10) which was detected by reference strand mediated conformation analysis and confirmed by DNA sequencing.
Pérez-Rodríguez
M
M
Anthony Nolan Research Institute, The Royal Free Hospital, London, United Kingdom.
Corell
A
A
Argüello
J R
JR
Cox
S T
ST
McWhinnie
A
A
Marsh
S G
SG
Madrigal
J A
JA
D000409:Alanine / Q000235:genetics*; D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D000409:Alanine