Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea.
A unique bicyclic peptide, moroidin (1), from the seeds of Celosia argentea (Amaranthaceae) strongly inhibited the polymerization of tubulin. The stereostructure of moroidin (1) was reinvestigated by spectroscopic data, chemical degradation, and molecular dynamics simulation.
Morita
H
H
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Shimbo
K
K
Shigemori
H
H
Kobayashi
J
J
D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014404:Tubulin / Q000096:biosynthesis
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; D014404:Tubulin; C409807:moroidin; D003078:Colchicine; D004121:Dimethyl Sulfoxide