title: [Modern noninvasive methods for terminating pregnancy in the 2nd trimester].
abstract: Pregnancy interruption upon medical indications between the 13th and 21st gestational weeks is carried out mainly by two-phase invasive techniques including intraamnial application of NaCl and vaginally prostaglandins, laminarie or solutio rivanoli, followed by a surgical treatment (instrumental revision). Because of its invasive character these techniques can cause severe complications. The application of prostaglandin analogues (P.G.) is safer but it is connected with gastrointestinal side effects and their action is often protrachirated especially "primigravida" with a undeveloped infantile P.V.C.U. the author proposes a highly effective non-invasive technique implementing the following combination: sensibilization with an antiprogestin (synthetic norsteroid--Ru 486), applied perorally: 1 tablet 200 mg; 24 hours before the intracervical (vaginal) insertion of the PGO2 tablet or gel. Results are extremely effective and good: the time for pregnancy interruption is reduced to more than 50% (average 5 to 10 hours), side effects and complications are minimized and the hospital stay is significantly reduced.
authors.affiliation: University Maternity Hospital Maĭchin Dom.
authors.forename: T
authors.initials: T
authors.lastname: Chernev
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage; D000028:Abortion, Induced / Q000379:methods*; D000282:Administration, Intravaginal; D000284:Administration, Oral; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000008:administration & dosage; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D013997:Time Factors
chemical_list: D000021:Abortifacient Agents, Steroidal; D015735:Mifepristone