title: A family of gamma-like calcium channel subunits.
abstract: The gamma subunit was initially identified as an auxiliary subunit of the skeletal muscle calcium channel complex. Evidence for the existence of further gamma subunits arose following the characterization of a genetic defect that induces epileptic seizures in stargazer mice. We present here the first account of a family of at least five putative gamma subunits that are predominantly expressed in brain. The gamma-2 and gamma-4 subunits shift the steady-state inactivation curve to more hyperpolarized potentials upon coexpression with the P/Q type alpha(1A) subunit. The coexpression of the gamma-5 subunit accelerates the time course of current activation and inactivation of the alpha(1G) T-type calcium channel.
authors.affiliation: Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Str. 29, 80802, Munich, Germany. klugbauer@ipt.med.tu-muenchen.de
authors.forename: N
authors.initials: N
authors.lastname: Klugbauer
authors.forename: S
authors.initials: S
authors.lastname: Dai
authors.forename: V
authors.initials: V
authors.lastname: Specht
authors.forename: L
authors.initials: L
authors.lastname: Lacinová
authors.forename: E
authors.initials: E
authors.lastname: Marais
authors.forename: G
authors.initials: G
authors.lastname: Bohn
authors.forename: F
authors.initials: F
authors.lastname: Hofmann
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001464:Barium / Q000378:metabolism; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020747:Calcium Channels, T-Type / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D003001:Cloning, Molecular; D004553:Electric Conductivity; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D006801:Humans; D017403:In Situ Hybridization; D007700:Kinetics; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D009928:Organ Specificity; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D014162:Transfection
chemical_list: D020747:Calcium Channels, T-Type; D020033:Protein Isoforms; D012333:RNA, Messenger; D011993:Recombinant Fusion Proteins; D001464:Barium; D002118:Calcium