Dynamics of intercellular communication during melanoma development.
Melanoma development involves processes determined collectively by various microenvironmental factors, among which intercellular communication has drawn increased attention. Cell-cell crosstalk mediated by cadherins and connexins results in coordinated regulation of cell growth, differentiation, apoptosis and migration. Abnormal expression of adhesion receptors and dysregulated intercellular communication appears to drive tumor development and progression.
Li
G
G
Program of Cell and Molecular Biology, Biomedical Graduate Studies, University of Pennsylvania School of Medicine and The Wistar Institute, Philadelphia, PA 19104, USA.
Herlyn
M
M
D000818:Animals; D015820:Cadherins / Q000378:metabolism / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D002450:Cell Communication / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology; D006801:Humans; D008545:Melanoma / Q000378:metabolism / Q000503:physiopathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000503:physiopathology*
D015820:Cadherins; D015815:Cell Adhesion Molecules