Calcium pumps: structural basis for and mechanism of calcium transmembrane transport.
Eukaryotic cells remove calcium from the cytosol using P-type pumps in the plasma membrane and in the sarco(endo)plasmic reticulum. These pumps share membrane topography and general mechanism of action, but differ in regulatory properties. Recent advances in the field include the three-dimensional structure of the sarco(endo)plasmic reticulum and further understanding of the transcriptional regulation of the plasma membrane P-type pump by calcium.
Carafoli
E
E
Department of Biochemistry, Center for the Study of Biomembranes of the National Council of Research (CNR), University of Padova, Padova, 35121, Italy. carafoli@civ.bio.unipd.it
Brini
M
M
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels / Q000737:chemistry*; D020865:Calcium Channels, P-Type / Q000737:chemistry; D000252:Calcium-Transporting ATPases / Q000737:chemistry*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry; D017433:Protein Structure, Secondary
D015220:Calcium Channels; D020865:Calcium Channels, P-Type; D020033:Protein Isoforms; D000252:Calcium-Transporting ATPases