title: Therapeutic effects and tolerability of fluvoxamine treatment in adolescents with dysthymia.
abstract: OBJECTIVE
  The aim of the study was to evaluate therapeutic effects and tolerability of fluvoxamine (150-200 mg daily) in 21 dysthymic adolescents.
  
  
  METHODS
  Twenty-one adolescents, attending psychiatric clinics, who met DSM-III-R criteria for dysthymia, without significant co-morbidity were the subjects.
  
  
  METHODS
  Axis I and II diagnoses were made by using SCID-P and SCID II. Score A of >13 on HAMD-S at baseline was mandatory. The HAMD-S was completed after 4, 8, and 26 weeks. Adverse effects were recorded after 1, 2, 4, and 8, weeks. Tolerability was assessed by using CGI-T after 1, 2, and 4 weeks. Adverse effects caused three subjects to withdraw from the study.
  
  
  RESULTS
  Good clinical response (decrease of HAMD-S score >50%) was observed after 4 weeks in 48% of patients; after 8 weeks in 56% of patients, and after 26 weeks in 44% patients. Relapse occurred in 34% of subjects. Fluvoxamine was well tolerated in 76.2% of the adolescents; poor toleration resulted in its discontinuation in 14.2% adolescents.
authors.affiliation: II Department of Psychiatry, Medical University of Lodz, Poland. polbvasi@post.ld.onet.pl
authors.forename: J
authors.initials: J
authors.lastname: Rabe-Jablonska
mesh_terms: D000293:Adolescent; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D019263:Dysthymic Disorder / Q000188:drug therapy*; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016666:Fluvoxamine