title: Synthesis and anti-inflammatory and analgesic activities of pyridyloxy- and phenoxyalkanoic acid derivatives.
abstract: Synthesis of pyridyloxy-, pyridyloxyphenoxy- and phenoxylphenoxyalkanate derivatives and their anti-inflammatory and analgesic activities were investigated. Analysis of structure-activity relationships showed that in pyridyloxyalkanoic acid derivatives anti-edematous potency was associated with the presence of chlorophenoxypropionic acid moiety and 2-nitrated methyl propionates contributed to the analgesic activity.
authors.affiliation: Natural Products Research Institute, Seoul National University, Korea. Khshin@plaza.snu.ac.kr
authors.forename: K H
authors.initials: KH
authors.lastname: Shi
authors.forename: S S
authors.initials: SS
authors.lastname: Lim
authors.forename: S H
authors.initials: SH
authors.lastname: Jung
authors.forename: J
authors.initials: J
authors.lastname: Ji
authors.forename: E B
authors.initials: EB
authors.lastname: Lee
authors.forename: D C
authors.initials: DC
authors.lastname: Kim
authors.forename: K J
authors.initials: KJ
authors.lastname: Shin
authors.forename: D J
authors.initials: DJ
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Park
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal