Molecular imprinting for drug bioanalysis. A review on the application of imprinted polymers to solid-phase extraction and binding assay.
Molecularly imprinted polymers have been applied as selective sorbents in several analytical techniques, including liquid chromatography, capillary electrophoresis and capillary electrochromatography, solid-phase extraction, and 'immunoassay'. An advantage of this type of sorbent is the possibility to synthesize polymers with selectivity pre-determined for a particular analyte. This review critically discusses the use of imprinted polymers for analysis of drugs and other compounds in biological samples, with emphasis on their use as highly selective solid-phase extraction sorbents for sample pre-concentration and alternative binding entities in immunoassay type protocols.
Andersson
L I
LI
Bioanalytical Chemistry, AstraZeneca R&D Södertälje, Sweden. lars.i.andersson@astrazeneca.com
D001667:Binding, Competitive; D001704:Biopolymers / Q000032:analysis; D002853:Chromatography, Liquid / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D005544:Forecasting; D007118:Immunoassay / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis; D011108:Polymers
D001704:Biopolymers; D004364:Pharmaceutical Preparations; D011108:Polymers