Clinical correlates and prognosis in early spindle coma.
OBJECTIVE
To determine the prognostic significance of spindle coma (SC) according to etiology and EEG reactivity.


METHODS
We reviewed 15 patients with SC due to various causes within 8 days of coma to determine the prognostic significance of this EEG pattern.


RESULTS
The outcome among survivors was favorable: among 13 survivors, 9 were independent in all activities of daily living (ADLs) at 6 months; 3 were dependent in all ADLs; and one remained in coma. EEG reactivity to noxious stimuli best predicted outcome: All patients (whatever the coma etiology) with EEG reactivity survived; conversely, not all patients without EEG reactivity died.


CONCLUSIONS
In our patients, EEG reactivity independent of etiology predicted survival, neurological examination did not predict outcome. Most SC survivors had a meaningful recovery achieving all ADLs. From the literature, the cause of SC was predictive of outcome: encephalopathy, seizures and trauma had the best prognosis while hypoxia, CRA and structural lesions carried the worst. Literature review revealed that 23% of patients [56/242] died or remained in a persistent vegetative state (PVS). Best outcomes occurred when SC was due to drugs, encephalopathy or seizures: (0/14 died or were in a PVS). With trauma 15% [25/169] died or were in a PVS). Intermediate outcomes occurred with hypoxia and cardio-respiratory arrest (CRA): 33% [7/21] died or were in a PVS. The gravest outcomes occurred with brain-stem and cerebral infarctions, and tumors: 73% [22/30] died or were in a PVS.
Kaplan
P W
PW
Department of Neurology, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, Baltimore, USA.
Genoud
D
D
Ho
T W
TW
Jallon
P
P
D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D003128:Coma / Q000175:diagnosis* / Q000209:etiology* / Q000534:rehabilitation; D004569:Electroencephalography; D005260:Female; D006323:Heart Arrest; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D011379:Prognosis; D020127:Recovery of Function; D012189:Retrospective Studies