Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.
Zhou
P
P
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Takaishi
Y
Y
Duan
H
H
Chen
B
B
Honda
G
G
Itoh
M
M
Takeda
Y
Y
Kodzhimatov
O K
OK
Lee
K H
KH
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006678:HIV / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D019380:Anti-HIV Agents; D003374:Coumarins; D016207:Cytokines