title: The use and development of retroviral vectors to deliver cytokine genes for cancer therapy.
abstract: In this review, we describe technical advancements of retroviral vectors to address issues of safety, titer, and clinical scale manufacturing to produce high-quality retroviral vector preparations that have made direct intratumoral administration of cytokine encoding recombinant vectors a feasible cancer therapy in the clinic. We also review possible further advances in retroviral vector design, which may prove important in expanding these clinical applications.
authors.affiliation: Chiron Corporation Center for Gene Therapy, San Diego, CA 92121, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Fong
authors.forename: S L
authors.initials: SL
authors.lastname: Sauter
authors.forename: C E
authors.initials: CE
authors.lastname: Ibañez
authors.forename: P L
authors.initials: PL
authors.lastname: Sheridan
authors.forename: D J
authors.initials: DJ
authors.lastname: Jolly
mesh_terms: D016207:Cytokines / Q000235:genetics*; D005822:Genetic Vectors / Q000009:adverse effects / Q000592:standards; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D012190:Retroviridae / Q000235:genetics*
chemical_list: D016207:Cytokines