title: Surgical treatment of T3 lung cancer invading the chest wall.
abstract: Lung tumors invading the chest wall are classed as belonging to the T3 group and are considered potentially resectable. Their management, however, is controversial, and extrapleural resection, when possible, is preferred to en bloc resection which is regarded as a far more invasive and dangerous operation. Five year survival rates for completely resected cases range in the literature from 25 to 35%, but survival rates are much worse if lymph node metastases are present. These poor outcomes have prompted the development of combined surgical approaches: preoperative radiation therapy, with or without chemotherapy, has been used with an improvement in resectability rates, but only modest results in terms of median survival; in a number of case series, increased operative morbidity and mortality have been reported with this approach. The present report relates to 122 patients treated by en bloc (20 cases) or extrapleural (102 cases) resection, 31 of whom also received neoadjuvant treatment. The operative mortality was 4.6%. Median survival was 17 months after en bloc resection and 19 months after extrapleural resection. Though no statistically significant difference was found, extrapleural resection would appear to yield better results than the en bloc procedure.
authors.affiliation: IV Clinica Chirurgica Generale, Università La Sapienza, Roma.
authors.forename: V
authors.initials: V
authors.lastname: Beltrami
authors.forename: M
authors.initials: M
authors.lastname: Bezzi
authors.forename: G
authors.initials: G
authors.lastname: Illuminati
authors.forename: A
authors.initials: A
authors.lastname: Forte
authors.forename: A
authors.initials: A
authors.lastname: Angelici
authors.forename: A
authors.initials: A
authors.lastname: Bertagni
authors.forename: A
authors.initials: A
authors.lastname: Ciulli
authors.forename: L
authors.initials: L
authors.lastname: Gallinaro
authors.forename: A
authors.initials: A
authors.lastname: Lorenzotti
authors.forename: G
authors.initials: G
authors.lastname: Montesano
authors.forename: P G
authors.initials: PG
authors.lastname: Palumbo
authors.forename: V
authors.initials: V
authors.lastname: Prece
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002283:Carcinoma, Bronchogenic / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D013899:Thoracic Neoplasms / Q000473:pathology / Q000601:surgery*