Stimulus compounding enhances conditioned suppression produced by cocaine-paired stimuli.
When 2 stimuli that occasion cocaine self-administration are presented in compound, their ability to increase cocaine-reinforced operant responding is substantially enhanced. The goal of the present experiment was to determine whether stimulus compounding could produce analogous enhancements of a classically conditioned drug effect. Food-maintained responding in rats was suppressed by a tone and a light that were individually paired with response-independent cocaine (3 mg/kg iv). This conditioned suppression was significantly enhanced when the stimuli were presented together in a stimulus-compounding test. The magnitude of this enhancement was similar to that in previous studies in which responding was suppressed by shock-paired stimuli. These results demonstrate that multiple drug-related cues interact in a predictable manner to influence both operant and classically conditioned behavior.
Panlilio
L V
LV
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA. lpanlili@intra.nida.nih.gov
Weiss
S J
SJ
Schindler
C W
CW
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects*; D003463:Cues; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D005502:Food; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D018765:Dopamine Uptake Inhibitors; D003042:Cocaine