title: Factor XIIIa+ dermal dendrocytes in erythema elevatum diutinum and ordinary cutaneous leukocytoclastic vasculitis lesions.
abstract: Factor XIIIa+ dermal dendrocytes belong to the dermal microvascular unit and are related to wound healing, angiogenic and fibrogenic processes. Erythema elevatum diutinum (EED) is a leukocytoclastic vasculitis followed by repair and fibrosis. In order to verify the involvement of fXIIIa+DD in the pathogenesis of EED and ordinary leukocytoclastic vasculitis (OLV) these cells were immune labeled with anti-factor XIIIa antibody and quantified in 15 biopsies of EED, 18 of OLV and compared with 11 fragments of normal skin (NS). The number of vessels was evaluated by endothelial cell staining with anti CD34 antibody. FXIIIa+DD appeared in both groups of vasculitis with hyperthophic dendrites, with no difference in their number at any level of the dermis. The number of fXIIIa+DD in the superficial dermis was higher in OLV than in NS (p<0.001). The number of dermal vessels in the EED group was higher at all dermis depths evaluated when compared with NS (p<0.05) and in the middle and deep dermis when compared with OLV (p<0.05). The results suggest the participation of fXIIIa+DD in the immunopathological mechanisms of both groups of vasculitis studied. However, there was no correlation between the number of fXIIIa+DD and angiogenesis and fibrogenesis in the EED lesions.
authors.affiliation: University of São Paulo School of Medicine, Department of Pathology and Dermatology, Brazil.
authors.forename: L S
authors.initials: LS
authors.lastname: Pacheco
authors.forename: M N
authors.initials: MN
authors.lastname: Sotto
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003713:Dendritic Cells / Q000201:enzymology* / Q000473:pathology; D020405:Dermis / Q000166:cytology*; D004890:Erythema / Q000201:enzymology* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011503:Transglutaminases / Q000378:metabolism*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000150:complications / Q000201:enzymology* / Q000473:pathology
chemical_list: D018952:Antigens, CD34; D011503:Transglutaminases