title: Isosteric replacement of acidic with neutral residues in extracellular loop-2 of the kappa-opioid receptor does not affect dynorphin A(1-13) affinity and function.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Ferguson
authors.forename: S
authors.initials: S
authors.lastname: Kramer
authors.forename: T G
authors.initials: TG
authors.lastname: Metzger
authors.forename: P Y
authors.initials: PY
authors.lastname: Law
authors.forename: P S
authors.initials: PS
authors.lastname: Portoghese
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D004399:Dynorphins / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000378:metabolism / Q000494:pharmacology*; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D011869:Radioligand Assay; D017473:Receptors, Opioid, kappa / Q000819:agonists* / Q000235:genetics / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D010446:Peptide Fragments; D017473:Receptors, Opioid, kappa; C026843:dynorphin (1-13); D004399:Dynorphins