Synthesis and antiviral assays of some 2-substituted benzimidazole-N-carbamates.
Some 2-substituted benzimidazole-N-carbamates were synthesized and tested in vitro for antiviral activity. Two derivatives were active at noncytotoxic concentrations. The results confirmed the importance of the substituents at the 2-position of benzimidazole; an isopropylcarboxamide group led to the best activity.
Garuti
L
L
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italy.
Roberti
M
M
Gentilomi
G
G
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D014709:Vero Cells
D000998:Antiviral Agents; D001562:Benzimidazoles; D002219:Carbamates