Immunolocalization of connexin 26 in the developing mouse cochlea.
Gap junctions play a pivotal role in embryonic development by forming specialized regions of cell-cell communication. In this study, we demonstrate the temporal-spatial distribution of connexin 26 in the embryonic and early postnatal mouse cochlea. Our results show localization of this gap junction protein to specific cochlear structures, including the inner and outer sulcus cells, the supporting cells of the inner hair cells, the mesenchyme derived portion of the stria vascularis, and the cells of the spiral ligament that interface with the basal cells of the stria vascularis. This suggests that this gap junction protein of served patterns of connexin 26 distribution is important for the differentiation and development of these structures (e.g., the role of the inner sulcus cells in producing the tectorial membrane).
Frenz
C M
CM
Department of Otolaryngology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Van De Water
T R
TR
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D000072259:Connexin 26; D017630:Connexins / Q000032:analysis* / Q000096:biosynthesis; D005260:Female; D017629:Gap Junctions / Q000737:chemistry* / Q000378:metabolism; D006199:Hair Cells, Auditory, Inner / Q000737:chemistry* / Q000166:cytology / Q000196:embryology*; D018072:Hair Cells, Auditory, Outer / Q000737:chemistry* / Q000166:cytology / Q000196:embryology*; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011247:Pregnancy
D017630:Connexins; C000607043:Gjb2 protein, mouse; D000072259:Connexin 26