title: Retinoblastoma in adults. Report of three cases and review of the literature.
abstract: Retinoblastoma usually presents in children younger than 5 years. To our knowledge, 20 cases of retinoblastoma in adults (older than 20 years) have been reported in the literature. Of 173 patients with histopathologically proven retinoblastoma seen in our institute, three were adults. All the patients had endophytic tumors with vitreous seeds. Ultrasonography did not reveal calcification in two cases. Immunohistochemistry with neuron-specific enolase was used to confirm the diagnosis in two cases. All three patients ultimately required enucleation. None of the patients had been referred with a diagnosis of retinoblastoma. The diagnosis of retinoblastoma should be considered in cases of whitish mass lesion in the fundus of an adult.
authors.affiliation: Medical Research Foundation, Chennai, India. MDSAAA35@giasmd01.vsn1.net.in
authors.forename: J
authors.initials: J
authors.lastname: Biswas
authors.forename: B
authors.initials: B
authors.lastname: Mani
authors.forename: M P
authors.initials: MP
authors.lastname: Shanmugam
authors.forename: D
authors.initials: D
authors.lastname: Patwardhan
authors.forename: K S
authors.initials: KS
authors.lastname: Kumar
authors.forename: S S
authors.initials: SS
authors.lastname: Badrinath
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor; D001706:Biopsy; D003937:Diagnosis, Differential; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000276:immunology / Q000378:metabolism; D019572:Retinal Neoplasms / Q000000981:diagnostic imaging / Q000201:enzymology / Q000473:pathology* / Q000601:surgery; D012175:Retinoblastoma / Q000000981:diagnostic imaging / Q000201:enzymology / Q000473:pathology* / Q000601:surgery; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; D010751:Phosphopyruvate Hydratase