title: Clinical efficacy and antimicrobial pharmacodynamics.
abstract: Changes in the susceptibility of bacterial pathogens and the availability of new antimicrobial drugs mean that physicians need to understand the underlying pharmacodynamics of each antimicrobial therapy. Antimicrobial pharmacodynamics determine clinical efficacy and should therefore be carefully considered when selecting appropriate antibiotic agents in the therapeutic setting.
authors.affiliation: Department of Medical Microbiology, City Hospital NHS Trust, Birmingham.
authors.forename: R
authors.initials: R
authors.lastname: Wise
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D003362:Cost-Benefit Analysis; D004352:Drug Resistance, Microbial / Q000276:immunology; D024841:Fluoroquinolones; D006192:Haemophilus Infections / Q000188:drug therapy; D006193:Haemophilus influenzae / Q000187:drug effects / Q000276:immunology; D006801:Humans; D018942:Macrolides; D010403:Penicillin Resistance / Q000276:immunology; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000517:prevention & control; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D018942:Macrolides