title: Regenerative periodontal surgery in interproximal intrabony defects with biodegradable barriers.
abstract: OBJECTIVE
  The comparison of the effects of guided-tissue regeneration (GTR) using 2 different biodegradable barriers (polylactide acetyltributyl citrate; polydioxanon) in 3- and 2-wall intrabony defects.
  
  
  METHODS
  The polydioxanon barrier is an experimental membrane for GTR therapy that consists of an continuous occlusive barrier that has a layer of slings on the side that is meant to face the mucoperiosteal flap. 15 patients provided 15 pairs of similar contralateral periodontal defects: 12 predominantly 2-wall and 18 predominantly 3-wall intrabony defects. Each defect was randomly assigned to treatment with either polylactide acetyltributyl citrate (control [c]) or polydioxanon (test [t]) devices. At baseline and 6 months after surgery, clinical measurements (P1I, GI, PPD, PAL-V) were performed.
  
  
  RESULTS
  Barrier exposure was commonly observed in both groups (control/test): 5/4 after 7 days, 9/11 after 14 days and 11/12 after 28 days postsurgically. 4 weeks after surgery, 77% of all barriers were exposed to some extent. However, both treatments revealed a significant GI reduction (p<0.05), PPD reduction [-4.63+/-1.85 mm (t), -4.17+/-1.89 mm (c); p<0.001] and PAL-V gain [3.97+/-1.17 mm (t), 3.40 mm+/-1.40 (c); p<0.001] 6 months after surgery. Regarding GI and PPD reduction as well as PAL-V gain, there were neither statistically significant nor clinically relevant differences between test and control: similar clinical results were found 6 months after surgical treatment using both biodegradable barriers.
  
  
  CONCLUSIONS
  Based on the results of the present study, the use of both biodegradable barriers in GTR therapy may be recommended.
authors.affiliation: Poliklinik für Zahnerhaltungskunde, Klinik für Mund-, Zahn- und Kieferkrankheiten, Ruprecht-Karls-Universität Heidelberg, Germany.
authors.forename: C E
authors.initials: CE
authors.lastname: Dörfer
authors.forename: T S
authors.initials: TS
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Steinbrenner
authors.forename: R
authors.initials: R
authors.lastname: Holle
authors.forename: P
authors.initials: P
authors.lastname: Eickholz
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D001672:Biocompatible Materials / Q000737:chemistry; D002951:Citrates / Q000737:chemistry; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009061:Mouth Mucosa / Q000601:surgery; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D010518:Periodontitis / Q000601:surgery; D010521:Periosteum / Q000601:surgery; D010968:Plasticizers / Q000737:chemistry; D016687:Polydioxanone / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry; D013223:Statistics as Topic
chemical_list: D001672:Biocompatible Materials; D002951:Citrates; D008567:Membranes, Artificial; D010968:Plasticizers; D011091:Polyesters; C014953:2-acetyltributylcitrate; D016687:Polydioxanone; C033616:poly(lactide)