Serum müllerian-inhibiting substance levels during normal menstrual cycles.
OBJECTIVE
To measure serum levels of müllerian-inhibiting substance (MIS) during the normal menstrual cycle.


METHODS
Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at -80 degrees C until assayed.


METHODS
University of Louisville Departments of Obstetrics and Gynecology and Surgery.


METHODS
Twenty healthy women 22-35 years of age with normal menstrual cycles.


METHODS
Blood samples were collected on menstrual cycle day two or three and on the day of LH surge plus one and plus seven or eight.


METHODS
Serum MIS levels were measured by using an enzyme-linked immunosorbent assay.


RESULTS
Serum MIS levels ranged from a low of 1.4 +/- 0.9 ng/mL (mean [+/-SD]) in the early follicular phase, peaked mid-cycle at 1.7 +/- 1.1 ng/mL, and decreased to 1.4 +/- 0.9 ng/mL in the mid-luteal phase of the normal menstrual cycle.


CONCLUSIONS
Fluctuations in serum MIS levels during the menstrual cycle suggest that MIS may have a regulatory role in folliculogenesis.
Cook
C L
CL
University of Louisville, Louisville, Kentucky, USA. clcook01@gwise.louisville.edu
Siow
Y
Y
Taylor
S
S
Fallat
M E
ME
D000328:Adult; D054304:Anti-Mullerian Hormone; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D012016:Reference Values; D013735:Testicular Hormones / Q000097:blood*
D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone