Nucleoside diphosphate kinase (nm23 protein) expression in retinoblastoma.
Forty-two enucleated eyes of 42 patients with unilateral retinoblastoma were studied histologically, including histochemically examination with anti-nm23 polyclonal antibody which does not recognise cDNA but its product. Primary tumours of >15 mm diameter with less evidence of apoptosis and with the most pleomorphic and anaplastic nuclei were associated with an increased risk of distant metastasis, but rosette formation did not discriminate. A high intensity of nm23 staining also indicated a tendency to metastasize, consistent with childhood neuroblastoma but in contrast to findings in carcinoma of the breast, colon and uterine cervix.
Bardak
Y
Y
Ophthalmology Department, Medical Faculty, Süleyman Demirel University, Isparta, Turkey. ybardak@hotmail.com
Cekiç
O
O
Ayhan
A
A
Günalp
I
I
Bulay
O
O
D000951:Antigens, Neoplasm / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002470:Cell Survival; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis*; D054778:NM23 Nucleoside Diphosphate Kinases; D009362:Neoplasm Metastasis; D009701:Nucleoside-Diphosphate Kinase / Q000096:biosynthesis*; D019572:Retinal Neoplasms / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D012175:Retinoblastoma / Q000201:enzymology* / Q000473:pathology / Q000556:secondary / Q000601:surgery; D012189:Retrospective Studies; D014157:Transcription Factors / Q000096:biosynthesis*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins