The application of DNA microarrays in gene expression analysis.
DNA microarray technology is a new and powerful technology that will substantially increase the speed of molecular biological research. This paper gives a survey of DNA microarray technology and its use in gene expression studies. The technical aspects and their potential improvements are discussed. These comprise array manufacturing and design, array hybridisation, scanning, and data handling. Furthermore, it is discussed how DNA microarrays can be applied in the working fields of: safety, functionality and health of food and gene discovery and pathway engineering in plants.
van Hal
N L
NL
RIKILT (State Institute for Quality Control of Agricultural Products), Gene Expression and Detection Centre, PO Box 230, 6700 AE, Wageningen, The Netherlands. n.l.w.vanhal@rikilt.wag-ur.nl
Vorst
O
O
van Houwelingen
A M
AM
Kok
E J
EJ
Peijnenburg
A
A
Aharoni
A
A
van Tunen
A J
AJ
Keijer
J
J
D001709:Biotechnology; D005524:Food Technology; D015870:Gene Expression; D005818:Genetic Engineering; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010945:Plants, Edible / Q000235:genetics; D012449:Safety