title: The evaluation of high risk and pre-invasive breast lesions and the decision process for follow up and surgical intervention.
abstract: Atypical epithelial hyperplasia, lobular carcinoma in situ (lobular neoplasia), radial scar, and ductal carcinoma in situ are considered high-risk lesions that predispose toward the future development of non-invasive or invasive breast cancer. Generally, those women with atypical epithelial hyperplasia, radial scar, or lobular carcinoma in situ can be managed conservatively by close surveillance. The minority of women may consider prophylactic mastectomy. Ductal carcinoma in situ can usually be managed by lumpectomy with or without radiation, with some patients requiring mastectomy due to extensive disease.
authors.affiliation: The New York Presbyterian Hospital, Cornell University Medical College, NY 10021, USA. rsimmons@strang.org
authors.forename: R M
authors.initials: RM
authors.lastname: Simmons
authors.forename: M P
authors.initials: MP
authors.lastname: Osborne
mesh_terms: D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology* / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000628:therapy; D018275:Carcinoma, Lobular / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008408:Mastectomy / Q000379:methods; D009361:Neoplasm Invasiveness; D011300:Preoperative Care; D011379:Prognosis; D018570:Risk Assessment