The lipid-laden foam cell: an elusive target for therapeutic intervention.
Brewer
H B
HB
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Building 10, Room 7N115, 10 Center Drive MSC 1666, Bethesda, Maryland 20892-1666, USA. bryan@mdb.nhlbi.nih.gov
D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D001161:Arteriosclerosis / Q000378:metabolism / Q000517:prevention & control*; D016026:Bone Marrow Transplantation; D001921:Brain / Q000201:enzymology; D002784:Cholesterol / Q000378:metabolism*; D002788:Cholesterol Esters / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000493:pharmacokinetics; D006224:Cricetinae; D004790:Enzyme Induction; D005487:Foam Cells / Q000201:enzymology* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000201:enzymology; D007422:Intestines / Q000201:enzymology; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009928:Organ Specificity; D011487:Protein Conformation; D012326:RNA Splicing; D011973:Receptors, LDL / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D012867:Skin / Q000201:enzymology; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D001057:Apolipoproteins E; D002788:Cholesterol Esters; D002791:Cholesterol, Dietary; D007527:Isoenzymes; D008074:Lipoproteins; D011973:Receptors, LDL; D002784:Cholesterol; D002785:Sterol O-Acyltransferase