Cell cycle regulation by the Cdc25 phosphatase family.
Activation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and Cdc25C. Cdc25A plays an important role at the G1/S-phase transition. Cdc25B undergoes activation during S-phase and plays a role in activating the mitotic kinase Cdk1/cyclin B in the cytoplasm. Active Cdk1/cyclin B then phosphorylates and activates Cdc25C leading to a positive feedback mechanism and to entry into mitosis. Cdc25A and B are potential human oncogenes. In addition, Cdc25 is a main player of the G2 arrest caused by DNA damage or in the presence of unreplicated DNA.
Nilsson
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Deutsches Krebsforschungszentrum, Dept. Applied Tumor Virology, Heidelberg, Germany.
Hoffmann
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D002384:Catalysis; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000502:physiology; D009857:Oncogenes; D015398:Signal Transduction; D020687:cdc25 Phosphatases / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D020666:ras-GRF1 / Q000378:metabolism*
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D020666:ras-GRF1; C517004:CDC25A protein, human; C517008:CDC25B protein, human; D020687:cdc25 Phosphatases