title: Serum levels of eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lipid peroxidation products, interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remission.
abstract: We determined serum levels of myeloperoxidase (MPO), eosinophilic cationic protein (ECP), reactive oxygen species measured as thiobarbituric acid reactive substances (TBARS), interleukin (IL)-5, and interferon (IFN)-gamma in 14 asthmatic children during an asthma attack and remission. Twelve healthy children served as controls. In atopic asthmatics, asthma attack resulted insignificant elevations of ECP, MPO, and TBARS compared to remission. TBARS levels were also higher at remission compared to controls. However, there was a great deal of overlap in the values of asthmatics and controls. IL-5 and IFN-gamma were detectable at low levels and only in a few patients. These results provide further evidence for participation of eosinophils, neutrophils and reactive oxygen species in the pathogenesis of acute asthma, and suggest that their products may be used in monitoring asthma attack. Serum IL-5 and IFN-gamma levels are not appropriate for use in the follow-up of asthmatic children.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Kalayci
authors.forename: Y
authors.initials: Y
authors.lastname: Saraçlar
authors.forename: K
authors.initials: K
authors.lastname: Kilinç
authors.forename: B E
authors.initials: BE
authors.lastname: Sekerel
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000209:etiology / Q000276:immunology; D001798:Blood Proteins / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D047091:Eosinophil Granule Proteins; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood; D015848:Interleukin-5 / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D009195:Peroxidase / Q000097:blood; D017382:Reactive Oxygen Species / Q000378:metabolism; D012129:Respiratory Function Tests; D012260:Ribonucleases; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D015848:Interleukin-5; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D017392:Thiobarbituric Acid Reactive Substances; D007371:Interferon-gamma; D009195:Peroxidase; D012260:Ribonucleases