title: Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women.
abstract: Cervical scrapes from 116 British women referred with cervical cancer were tested for the presence of high oncogenic risk human papillomavirus (HPV) genotypes (HPV(hr)). Ninety-four per cent of the scrapes had one or more of these virus types and 66% were HPV16-positive. HPV18 was more frequent in adenocarcinoma. No evidence was found for an increased cancer risk associated with the HPV16 E6 350G variant. The HLA DRB1* and DQB1* alleles in these women and in 155 women with normal cytology and negative for HPV(hr) DNA were compared. DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer. This was more marked in cancers positive for HPV types other than HPV16. In contrast, DRB1*1501 alone and in combination with DQB1*0602 was not significantly elevated in cancers overall, but did show some excess in HPV16-positive cancers (2P = 0.05), associated with HPV16-positive cervical cancers. Taking all cancers together, a marginally significant protective effect was found for DQB1*0501 (2P = 0.03) but no protective effect could be seen for DRB1*1301.
authors.affiliation: Department of Mathematics, Statistics & Epidemiology, Imperial Cancer Research Fund, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Cuzick
authors.forename: G
authors.initials: G
authors.lastname: Terry
authors.forename: L
authors.initials: L
authors.lastname: Ho
authors.forename: J
authors.initials: J
authors.lastname: Monaghan
authors.forename: A
authors.initials: A
authors.lastname: Lopes
authors.forename: P
authors.initials: P
authors.lastname: Clarkson
authors.forename: I
authors.initials: I
authors.lastname: Duncan
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics* / Q000821:virology*; D004739:England / Q000453:epidemiology; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D014412:Tumor Virus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics* / Q000821:virology*; D014626:Vaginal Smears
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens