title: Role of motility in adherence to and invasion of a fish cell line by Vibrio anguillarum.
abstract: To understand further the role of the flagellum of Vibrio anguillarum in virulence, invasive and adhesive properties of isogenic motility mutants were analyzed by using a chinook salmon embryo cell line. Adhesion was unaffected but invasion of the cell line was significantly decreased in nonmotile or partially motile mutants, and the chemotactic mutant was hyperinvasive. These results suggest that active motility aids invasion by V. anguillarum, both in vivo and in vitro.
authors.affiliation: Department of Cell and Molecular Biology, Pathology, Umeâ University, S-901 87 Umeå, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Ormonde
authors.forename: P
authors.initials: P
authors.lastname: Hörstedt
authors.forename: R
authors.initials: R
authors.lastname: O'Toole
authors.forename: D L
authors.initials: DL
authors.lastname: Milton
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D002460:Cell Line; D002633:Chemotaxis; D005407:Flagella / Q000235:genetics; D020409:Molecular Motor Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D012474:Salmon / Q000382:microbiology*; D014733:Vibrio / Q000472:pathogenicity*
chemical_list: D001425:Bacterial Outer Membrane Proteins; D020409:Molecular Motor Proteins; C088135:MotY protein, Vibrio