Cortical laminar necrosis caused by immunosuppressive therapy and chemotherapy.
We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). Initial neuroradiologic studies showed cortical and white matter involvement. Follow-up studies showed cortical hyper-intense lesions on T1-weighted MR images, consistent with cortical laminar necrosis. The clinical and radiologic data indicate that a transient hypoxic-ischemic process could have been responsible for the encephalic lesions in these three patients.
Bargalló
N
N
Department of Radiology, Hospital Clínic Provincial de Barcelona, Spain.
Burrel
M
M
Berenguer
J
J
Cofan
F
F
Buñesch
L
L
Mercader
J M
JM
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D016572:Cyclosporine / Q000009:adverse effects; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D009336:Necrosis; D016559:Tacrolimus / Q000009:adverse effects; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000009:adverse effects
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D014750:Vincristine; D016572:Cyclosporine; D016559:Tacrolimus; D008727:Methotrexate