title: Gilbert's syndrome accounts for the phenotypic variability of congenital dyserythropoietic anemia type II (CDA-II).
abstract: The molecular basis for the considerable variation of serum bilirubin levels and the incidence of gallstone formation in patients with congenital dyserythropoietic anemia (CDA) type II are unknown. We show that the combined effect of an increased bilirubin load caused by dyserythropoiesis in CDA II and decreased bilirubin conjugation caused by reduced expression of uridine diphosphate glucuronosyl transferase (UGT1A) would increase the risk of hyperbilirubinemia (P <.005) and gallstone formation (chi(2): P <. 001). The rate of gallstone formation in patients with CDA II is 4. 75-fold the rate of patients without Gilbert's syndrome, and gallstone diagnosis occurs at a younger age (P < 0.01). These findings should be considered during the follow-up of patients with CDA II.
authors.affiliation: Dipartimento di Pediatria, Seconda Università degli Studi di Napoli, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Perrotta
authors.forename: E M
authors.initials: EM
authors.lastname: del Giudice
authors.forename: R
authors.initials: R
authors.lastname: Carbone
authors.forename: V
authors.initials: V
authors.lastname: Servedio
authors.forename: F
authors.initials: F
authors.lastname: Schettini
authors.forename: B
authors.initials: B
authors.lastname: Nobili
authors.forename: A
authors.initials: A
authors.lastname: Iolascon
mesh_terms: D000293:Adolescent; D000328:Adult; D000742:Anemia, Dyserythropoietic, Congenital / Q000150:complications / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002769:Cholelithiasis / Q000209:etiology / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005878:Gilbert Disease / Q000150:complications / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology / Q000235:genetics; D007558:Italy; D008297:Male; D009004:Monosaccharide Transport Proteins / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D012189:Retrospective Studies; D000099237:UDP-Galactose Translocators
chemical_list: D009004:Monosaccharide Transport Proteins; D000099237:UDP-Galactose Translocators