PriA-directed replication fork restart in Escherichia coli.
The encounter of a replication fork with either a damaged DNA template, a nick in the template strand or a 'frozen' protein-DNA complex can stall the replisome and cause it to fall apart. Such an event generates a requirement for replication fork restart if the cell is going to survive. Recent evidence shows that replication fork restart is effected by the action of the recombination proteins generating a substrate for PriA-directed replication fork assembly.
Marians
K J
KJ
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. k-marians@ski.mskcc.org
D002876:Chromosomes, Bacterial; D004261:DNA Replication / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D004926:Escherichia coli / Q000235:genetics*; D010641:Phenotype; D051716:Replication Protein A
D004268:DNA-Binding Proteins; D051716:Replication Protein A