Discrepancies between effects of recombinant human growth hormone on absorption and secretion of water and electrolytes on the human jejunum compared to results reported on rat jejunum.
Previous studies in rats showed that the administration of recombinant human growth hormone markedly increased intestinal absorption of electrolytes and water and suggested that growth hormone would be a useful antidiarrheal agent. We therefore examined the effect of recombinant human growth hormone on the human jejunum in vivo, using a triple lumen nonabsorbable marker technique. Healthy subjects were studied on two different test days, one as a control and a second where recombinant human growth hormone was injected subcutaneously in a dose of 100 microg/kg. With this dose we achieved equal or higher growth hormone serum levels than in previous rat studies. However the administration of recombinant human growth hormone did not stimulate absorption or inhibit secretion of water and electrolytes in the human jejunum in vivo. We believe that the discrepancy between humans and rats is most likely due to the species difference rather than to differences in methods that were used. Therefore recombinant human growth hormone cannot be considered a useful proabsorptive antidiarrheal agent in humans.
Högenauer
C
C
Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA.
Santa Ana
C A
CA
Porter
J L
JL
Fordtran
J S
JS
D000328:Adult; D000818:Animals; D004573:Electrolytes / Q000378:metabolism*; D005260:Female; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology; D013045:Species Specificity; D014867:Water / Q000378:metabolism*
D004573:Electrolytes; D011994:Recombinant Proteins; D014867:Water; D019382:Human Growth Hormone