RNA folding: beyond Watson-Crick pairs.
Several crystal structures of RNA fragments, alone or in complex with a specific protein, have been recently solved. In addition, the structures of an artificial ribozyme, the leadzyme, and the cleavage product of a human pathogen ribozyme, have extended the structural diversity of ribozyme architectures. The attained set of folding rules and motifs expand the repertoire seen previously in tRNA structures.
Westhof
E
E
UPR9002, Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg-Cedex, F-67084, France. E.Westhof@ibmc.u-strasbg.fr.
Fritsch
V
V
D020029:Base Pairing; D006801:Humans; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*
D012313:RNA