title: Prophylactic mastectomy; evolving perspectives.
abstract: It is not at all uncommon for surgeons dealing with breast disease to be confronted with the issue of prophylactic mastectomy. Recent advances in understanding the genetic basis of susceptibility to breast cancer and a better identification of the histological factors affecting a woman's lifetime risk of developing breast cancer have contributed to placing prophylactic mastectomy in a proper clinical perspective. Existing data suggest that prophylactic total mastectomy significantly reduces, but does not totally eliminate, the risk of subsequent development of cancer. However, the benefit of prophylactic mastectomy over alternative strategies (surveillance and chemoprevention) remains to be proven. Currently, prophylactic mastectomy may be considered in a few, carefully selected patients. The decision to perform a prophylactic mastectomy should be a multidisciplinary one. Detailed patient' counselling is very important; the patient should understand the limitations of prophylactic mastectomy and the need for postoperative follow-up. Furthermore, she should be well informed about the alternative strategies.
authors.affiliation: Department of Surgery, 251 Hellenic Air Force (HAF) General Hospital, Athens, Greece. georgesakorafas@yahoo.com
authors.forename: G H
authors.initials: GH
authors.lastname: Sakorafas
authors.forename: A G
authors.initials: AG
authors.lastname: Tsiotou
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000235:genetics / Q000517:prevention & control / Q000601:surgery*; D003376:Counseling; D003657:Decision Making; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000009:adverse effects / Q000379:methods*; D008875:Middle Aged; D017060:Patient Satisfaction
chemical_list: D000970:Antineoplastic Agents