title: Mannan-binding lectin concentration during normal human pregnancy.
abstract: Relative deficiency of mannan-binding lectin (MBL) is associated with recurrent miscarriage. To investigate whether MBL concentration alters as a result of pregnancy, serial measurements were made in 14 patients before and during normal early pregnancy. Additionally, a longitudinal study was made of one individual over several years and including two normal pregnancies. Three (20%) subjects experienced a significant increase in MBL concentration during pregnancy. It was concluded that a modest but significant increase in MBL concentration can result from pregnancy, but it is a rare occurrence in the first trimester.
authors.affiliation: Academic Unit, Department of Transfusion Medicine, 2 Forrest Road, Edinburgh EH1 2QN, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: Kilpatrick
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000628:therapy; D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D037222:Collectins; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007962:Leukocytes / Q000276:immunology; D011247:Pregnancy
chemical_list: D002352:Carrier Proteins; D037222:Collectins