A randomized, comparative study of fluorometholone 0.2% and fluorometholone 0.1% acetate after photorefractive keratectomy.
OBJECTIVE
To compare the efficacy and tolerance of fluorometholone 0.1% acetate and fluorometholone 0.2% eyedrops in the postoperative management of photorefractive keratectomy (PRK).


METHODS
A randomised single-blind comparative study was performed on two groups of 30 patients who underwent myopic PRK. The first group was given fluorometholone 0.1% acetate and the second fluorometholone 0.2%. Uncorrected and best corrected visual acuity, haze, IOP and local tolerance were evaluated. Statistical analysis was done using parametric and non-parametric tests.


RESULTS
Visual acuity did not differ in the two groups; both were homogeneous as far as refractive error and haze were concerned. Three patients (10%) treated with fluorometholone 0.2% and two patients (6.6%) with fluorometholone 0.1% acetate developed ocular hypertension, but this was not statistically significant.


CONCLUSIONS
Fluorometholone 0.1% acetate was effective on inflammation after PRK, with the same efficacy as fluorometholone 0.2%.
Vetrugno
M
M
Department of Ophthalmology and Otorhinolaryngology, University of Bari, Italy. oftalmo@cimedoc.uniba.it
Quaranta
G M
GM
Maino
A
A
Cardia
L
L
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005469:Fluorometholone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D019466:Glare; D005938:Glucocorticoids; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D054018:Lasers, Excimer; D008297:Male; D009216:Myopia / Q000601:surgery*; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D018903:Photorefractive Keratectomy / Q000009:adverse effects*; D012449:Safety; D016037:Single-Blind Method; D014606:Uveitis, Anterior / Q000209:etiology / Q000517:prevention & control*; D014792:Visual Acuity / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D005469:Fluorometholone