Peripheral administration of a serine protease inhibitor blocks kindling.
An inhibitor of tissue plasminogen activator (tPA) was tested for its effects on the rapid kindling induced by a series of afterdischarges (ADs) triggered in hippocampus over a 3-h period. Rats injected with vehicle prior to the session had prolonged ADs in tests carried out 10 days later. This was not the case for animals treated with the inhibitor. These findings support the hypothesis that activity-driven proteolysis contributes importantly to the production of long-lasting physiological changes.
Hoffman
K B
KB
Ancile Pharmaceuticals, San Diego, CA 92121, USA.
Hwee
V
V
Larson
J
J
Lynch
G
G
D000818:Animals; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007696:Kindling, Neurologic / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D013450:Sulfones / Q000494:pharmacology*; D010959:Tissue Plasminogen Activator / Q000187:drug effects* / Q000502:physiology; D014361:Trypsin Inhibitors / Q000494:pharmacology*
D015842:Serine Proteinase Inhibitors; D013450:Sulfones; D014361:Trypsin Inhibitors; C002010:4-(2-aminoethyl)benzenesulfonylfluoride; D010959:Tissue Plasminogen Activator