title: Antipsychotic drug use patterns and the cost of treating schizophrenia.
abstract: This study investigated the relationships between antipsychotic drug use patterns and direct costs for 3,321 Medi-Cal patients with schizophrenia. Ordinary least-squares regression models were used to estimate the impact on costs of receiving antipsychotic drug treatment, delays in treatment, changes in therapy, and continuous therapy. Average costs were $25,940 per year per patient. Having used an antipsychotic drug was correlated with lower psychiatric hospital costs ($2,846 less) but higher nursing home costs. Completing one year of uninterrupted drug therapy was correlated with higher nursing home costs. Delayed drug treatment and changes in therapy increased the cost by $9,418 and $9,719, respectively.
authors.affiliation: Department of Pharmaceutical Economics and Policy, Univeristy of Southern California, 1540 East Alcazar Street, Los Angeles, USA. combs@hsc.usc.edu
authors.forename: J S
authors.initials: JS
authors.lastname: McCombs
authors.forename: M B
authors.initials: MB
authors.lastname: Nichol
authors.forename: B M
authors.initials: BM
authors.lastname: Johnstone
authors.forename: G L
authors.initials: GL
authors.lastname: Stimmel
authors.forename: J
authors.initials: J
authors.lastname: Shi
authors.forename: R
authors.initials: R
authors.lastname: Smith
mesh_terms: D000328:Adult; D000368:Aged; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000191:economics* / Q000627:therapeutic use; D002140:California; D003362:Cost-Benefit Analysis / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000191:economics; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010343:Patient Admission / Q000191:economics; D012559:Schizophrenia / Q000188:drug therapy / Q000191:economics*
chemical_list: D014150:Antipsychotic Agents