[Generic screening for breast cancer].
Following the cloning of BRCA1 and BRCA2 it has been suggested that genetic screening may be of benefit for women at high familial risk. To be able to assess whether this is the case more research is needed on the penetrance of the different mutations, their prevalence in the population, the biological and environmental factors affecting the development of cancer in mutation carriers and the natural history of genetically determined breast cancer. Furthermore, studies on the efficacy of preventive measures, on counselling and on psychological effects of testing are also needed.
Ponti
A
A
Dipartimento di Oncologia dell'Ospedale S. Giovanni Antica Sede, A.S.L.1, Torino.
Giordano
L
L
D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors