title: [123I]IPCIT and [123I]beta-CIT as SPECT tracers for the dopamine transporter: a comparative analysis in nonhuman primates.
abstract: [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([123I]-CIT) and its isopropylester analog [123I]PCIT, both of which are phenyltropane derivatives of cocaine with high affinity for the dopamine (DA) transporter, were compared using single photon emission computed tomography in nonhuman primates. Although IPCIT is significantly more selective for the DA transporter than beta-CIT, striatal distribution volumes of specifically bound tracer were similar for both tracers. Compartmental modeling results were compared with a simple peak equilibrium method used previously by this group. The peak equilibrium method is shown to overestimate striatal distribution volumes, primarily due to a difference in the calculated time of peak specific uptake.
authors.affiliation: Yale University and VA Connecticut Healthcare Center, West Haven 06516, USA. ellen.scanley@yale.edu
authors.forename: B E
authors.initials: BE
authors.lastname: Scanley
authors.forename: M S
authors.initials: MS
authors.lastname: Gandelman
authors.forename: M
authors.initials: M
authors.lastname: Laruelle
authors.forename: M S
authors.initials: MS
authors.lastname: Al-Tikriti
authors.forename: R M
authors.initials: RM
authors.lastname: Baldwin
authors.forename: S S
authors.initials: SS
authors.lastname: Zoghbi
authors.forename: P B
authors.initials: PB
authors.lastname: Hoffer
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: J L
authors.initials: JL
authors.lastname: Neumeyer
authors.forename: R B
authors.initials: RB
authors.lastname: Innis
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003042:Cocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009419:Nerve Tissue Proteins; D010215:Papio; D013045:Species Specificity; D013997:Time Factors; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D008024:Ligands; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C079213:RTI 121; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine