Thyroid hormone action and brain development.
Thyroid hormone (TH) plays a crucial role in brain development. Developing rodent cerebellum might be an excellent model for studying the molecular mechanisms of TH action in the brain because perinatal hypothyroidism greatly affects its ontogeny. Although the TH-regulated genes that play crucial roles in cerebellar development have not yet been fully characterized, recent studies have provided novel insights into TH action in brain development.
Koibuchi
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Department of Physiology, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan. koibuchi@dokkyomed.ac.jp
Chin
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WW
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development; D001921:Brain / Q000196:embryology* / Q000254:growth & development*; D004622:Embryo, Mammalian / Q000502:physiology; D004625:Embryo, Nonmammalian; D005314:Embryonic and Fetal Development; D013963:Thyroid Hormones / Q000502:physiology*
D013963:Thyroid Hormones