title: Treatment of acute disseminated encephalomyelitis with intravenous immunoglobulin.
abstract: Acute disseminated encephalomyelitis (ADEM) is a presumed immune-mediated, demyelinating disease of the CNS for which the standard treatment is high-dose steroids. We describe two patients with ADEM in whom treatment with IV methylprednisolone coincided with deterioration in their clinical status. They were subsequently treated with IV immunoglobulin and exhibited dramatic clinical improvement, with return to their previous level of functioning.
authors.affiliation: McGill University Health Centre, the Montreal Neurological Hospital, Québec, Canada. mdjs@musica.mcgill.ca
authors.forename: D J
authors.initials: DJ
authors.lastname: Sahlas
authors.forename: S P
authors.initials: SP
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Guerin
authors.forename: M
authors.initials: M
authors.lastname: Veilleux
authors.forename: G
authors.initials: G
authors.lastname: Francis
mesh_terms: D000208:Acute Disease; D000328:Adult; D004673:Encephalomyelitis, Acute Disseminated / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging
chemical_list: D016756:Immunoglobulins, Intravenous