Derivatised lipids in membranes. Physico-chemical aspects of N-biotinyl phosphatidylethanolamines, N-acyl phosphatidylethanolamines and N-acyl ethanolamines.
The physical properties of N-biotinyl phosphatidylethanolamines, N-acyl phosphatidylethanolamines and of N-acyl ethanolamines, in aqueous dispersions, are reviewed. Emphasis is placed on the calorimetric (i.e. chain melting) properties, the thermotropic phase behaviour, certain aspects of the structure and dynamics, and the miscibility with other membrane lipids. In the case of N-biotinyl phosphatidylethanolamines, the specific binding of avidin, and in the case of N-acyl ethanolamines, the function of the third chain, is also considered. All of these properties are relevant to the role of these rather unusual lipids in membranes.
Marsh
D
D
Max-Planck-Institut für biophysikalische Chemie, Abt. Spektroskopie, Göttingen, Germany. dmarsh@gwdg.de
Swamy
M J
MJ
D001360:Avidin / Q000737:chemistry; D001710:Biotin / Q000031:analogs & derivatives / Q000737:chemistry; D019921:Biotinylation; D002151:Calorimetry; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry; D004578:Electron Spin Resonance Spectroscopy; D004983:Ethanolamines / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000737:chemistry*; D008958:Models, Molecular; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D011485:Protein Binding; D019809:Streptavidin / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics; D014961:X-Ray Diffraction
D004983:Ethanolamines; D008563:Membrane Lipids; D010714:Phosphatidylethanolamines; C094175:dimyristoyl-N-biotinylphosphatidylethanolamine; D001360:Avidin; D001710:Biotin; D019809:Streptavidin; D004134:Dimyristoylphosphatidylcholine