Palladium-catalyzed synthesis of cephalotaxine analogues.
The synthesis of cephalotaxine ring analogues 10 was achieved by two successive intramolecular palladium-catalyzed reactions of 12 via 11, namely an allylic amination and a Heck reaction. The substrates 12 were obtained by alkylation of primary amines 13 with tosylates 14.
Tietze
L F
LF
Institut für Organische Chemie der Universität, Göttingen, Germany. ltietze@gwdg.de
Schirok
H
H
Wöhrmann
M
M
D000478:Alkylation; D002384:Catalysis; D006248:Harringtonines / Q000138:chemical synthesis*; D000077863:Homoharringtonine; D010165:Palladium
D006248:Harringtonines; D010165:Palladium; D000077863:Homoharringtonine