title: DX-9065a, a specific factor Xa inhibitor, as a universal anticoagulant for blood collection tubes.
abstract: DX-9065a is a direct and selective factor Xa inhibitor. We evaluated the usefulness of DX-9065a in anticoagulating specimens for routine laboratory tests. Results using blood anticoagulated with DX9065a corresponded well with results with blood treated with ethylendiamine tetraacetic acid (EDTA) in the complete blood count (CBC), including white blood cell (WBC) differential count and morphology of blood cells. Clinical chemistry results from DX-9065a-treated samples were similar to results obtained with serum specimens except for leucine aminopeptidase (LAP) and cholinesterase (Ch-E). Thus, DX-9065a may be a useful universal anticoagulant for laboratory medicine.
authors.affiliation: Department of Laboratory Medicine, Osaka City University Hospital, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kumura
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: K
authors.initials: K
authors.lastname: Tominaga
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000925:Anticoagulants; D001772:Blood Cell Count; D001774:Blood Chemical Analysis / Q000379:methods*; D001800:Blood Specimen Collection / Q000295:instrumentation* / Q000379:methods*; D002624:Chemistry, Clinical / Q000379:methods; D002802:Cholinesterases / Q000097:blood; D003955:Diagnostic Tests, Routine; D004492:Edetic Acid; D065427:Factor Xa Inhibitors; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000097:blood; D009281:Naphthalenes; D011422:Propionates; D012044:Regression Analysis
chemical_list: C086910:(2S)-2-(4-(((3S)-1-acetimidoyl-3-pyrrolidinyl)oxy)phenyl)-3-(7-amidino-2-naphtyl)propanoic acid; D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D009281:Naphthalenes; D011422:Propionates; D004492:Edetic Acid; D002802:Cholinesterases; D007931:Leucyl Aminopeptidase