Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer.
Mutation of p53, a tumour suppressor gene, is uncommon in cervical cancer but the detection of human papillomavirus (HPV) DNA in cervical cancer is common. The findings of increased susceptibility to degradation of p53 by E6 protein of HPV16/18 in cervical cancer with homozygous arginine at codon 72 (HA72) of p53 led to this study on whether cervical cancers with HA72 were more aggressive with the increase in the rate of loss of p53 function. In 102 cervical cancers, 76.5% were HPV16/18 positive and 30% had HA72. No survival difference was detected between HA72 and non-HA72 tumours irrespective of HPV16/18 status. Furthermore, the detection of HPV16/18 in cervical cancer was found not to be of prognostic significance in this study.
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Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong. hysngan@hkucc.hku.hk
Liu
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Liu
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Cheng
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Wong
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D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001120:Arginine / Q000235:genetics*; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics / Q000401:mortality / Q000821:virology; D003062:Codon / Q000235:genetics*; D004268:DNA-Binding Proteins; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008875:Middle Aged; D009856:Oncogene Proteins, Viral / Q000502:physiology; D027383:Papillomaviridae / Q000302:isolation & purification; D011379:Prognosis; D011392:Proline / Q000235:genetics; D012097:Repressor Proteins; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000821:virology
D003062:Codon; D004268:DNA-Binding Proteins; C068651:E6 protein, Human papillomavirus type 16; C052603:E6 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53; D001120:Arginine; D011392:Proline