title: Determination of glomerular filtration rate using a dual-detector gamma camera and the geometric mean of renal activity: correlation with the Tc-99m DTPA plasma clearance method.
abstract: OBJECTIVE
  In this study, the authors studied the use of a dual-detector gamma camera to measure the glomerular filtration rate (GFR).
  
  
  METHODS
  Thirty-three patients with a wide range of renal function participated in this study. The GFR was measured using a dual-detector gamma camera by calculating the geometric mean of activity from each kidney and using an outline background. These results were compared with the GFR estimates obtained from Tc-99m DTPA plasma clearance using a multiple blood sample method.
  
  
  RESULTS
  Correlation was excellent between GFR estimated using the dual-detector gamma camera and GFR measured using the plasma clearance of Tc-99m DTPA with multiple blood samples (r = 0.89). The correlation was especially strong in children younger than 13 years (r = 0.94).
  
  
  CONCLUSIONS
  Measuring the GFR using a dual-detector gamma camera and calculating the geometric mean of renal activity yields relatively accurate results.
authors.affiliation: Department of Nuclear Medicine, The University of Texas, MD Anderson Cancer Center, Houston 77030, USA. edelpassand@di.mdacc.tmc.edu
authors.forename: E S
authors.initials: ES
authors.lastname: Delpassand
authors.forename: K
authors.initials: K
authors.lastname: Homayoon
authors.forename: T
authors.initials: T
authors.lastname: Madden
authors.forename: M
authors.initials: M
authors.lastname: Mathai
authors.forename: D A
authors.initials: DA
authors.lastname: Podoloff
mesh_terms: D000328:Adult; D002648:Child; D015902:Gamma Cameras; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D011866:Radioisotope Renography; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate