[Carcinoma arising within mammary fibroadenomas. A study of six patients].
We report six cases of carcinomas arising within fibroadenomas. Fibroadenoma is a benign neoplasm occurring in young women. Its association with carcinomas is unfrequent and particularly reported in older women. Few data are available on the histologic features of fibroadenomas harboring malignant lesions. In this study, most cases of fibroadenomas showed cysts, sclerosing adenosis, epithelial calcifications or papillary apocrine changes. These fibroadenomas are classified as complex and are a long-term risk factor for breast cancer. The complex fibroadenoma may be specific of fibroadenoma associated with carcinoma.
Tissier
F
F
Service d'Anatomie Pathologique, Hôpital Cochin, Paris, France.
De Roquancourt
A
A
Astier
B
B
Espie
M
M
Clot
P
P
Marty
M
M
Janin
A
A
D000232:Adenofibroma / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002114:Calcinosis / Q000473:pathology; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D005348:Fibrocystic Breast Disease / Q000473:pathology; D006801:Humans; D008875:Middle Aged