Regulatory circuits in Caulobacter.
The transcriptional regulator CtrA controls DNA replication, DNA methylation and cell division during the Caulobacter cell cycle. Recent work on this master cell cycle regulator has provided insight into its control mechanisms. Feedback regulation of ctrA transcription together with timed proteolysis of CtrA determine the levels of the regulator during the cell cycle. Multiple phosphorylation pathways regulate CtrA activity by a mechanism that includes dynamic subcellular localization of the corresponding sensor kinases.
Osterås
M
M
Division of Molecular Microbiology, Biozentrum, University of Basel, Basel, CH-4056, Switzerland.
Jenal
U
U
D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016935:Caulobacter crescentus / Q000166:cytology* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D004268:DNA-Binding Proteins; D004789:Enzyme Activation; D005246:Feedback; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors
D001426:Bacterial Proteins; C097706:CtrA protein, Caulobacter; D004268:DNA-Binding Proteins; D014157:Transcription Factors; D011494:Protein Kinases