title: [Haplotypes of two diallelic Y chromosome loci in the indigenous and migrant populations of Siberia].
abstract: Two diallelic Y-chromosome markers, the Y Alu polymorphism (YAP) and the T-C transition (Tat), were analyzed in the indigenous (Tuvinian, Buryat, Northern Altaic, and Tatar) and migrant (Slavic) populations of Siberia. A high frequency of the allele C was revealed in several indigenous populations (25-55%) and in Russians (20.8%). The YAP+ allele occurred at a surprisingly high frequency (31.4%) and was completely linked with the C allele in Buryats. The YAP+ chromosome was also found in the Tuvinian population (1.5%). The two diallelic loci showed a marked linkage disequilibrium (D = 92.4%) in the total sample. The YAP-/T and YAP-/C haplotypes prevailed in both indigenous and migrant populations: their respective frequencies were 80.4 and 19.6% in the Slavic population and 71.8 and 19.9%, respectively, in the indigenous one. The YAP+/C (7.8%) and YAP+/T (0.5%) haplotypes were found only in the indigenous population. An appreciable heterogeneity in haplotype frequency distribution between regional subpopulations was revealed in Russians, Tuvinians, and Buryats. The origin and evolution of Y-chromosome lines in Northern Asia are considered.
authors.affiliation: Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Stepanov
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
mesh_terms: D000483:Alleles; D004641:Emigration and Immigration; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D011995:Recombination, Genetic; D014998:Y Chromosome