Mucoadhesive and physicochemical characterization of Carbopol-Poloxamer gels containing triamcinolone acetonide.
The viscosity and bioadhesive property of Carbopol-Poloxamer gels containing triamcinolone acetonide to mucosa were tested according to various concentrations of Carbopol gels of various pH. The increase in Carbopol concentration caused increased viscosity and bioadhesiveness. The neutralization of pH in various concentrations of Carbopol gels showed the increased viscosity, showing the highest viscosity and highest bioadhesiveness when neutralized to pH 6. A relationship between the viscosity and bioadhesive strength was shown from the neutralized Carbopol gels. The physicochemical interactions between triamcinolone acetonide and polymers were investigated by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectrophotometry. According to FTIR and XRD studies, the drug did not show any evidence of an interaction with the polymers used and was present in an unchanged state.
Shin
S C
SC
College of Pharmacy, Chonnam National University, Kwangju, Korea.
Kim
J Y
JY
Oh
I J
IJ
D000180:Acrylic Resins; D000268:Adhesiveness; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D005079:Excipients / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011480:Protease Inhibitors / Q000737:chemistry*; D013053:Spectrophotometry; D014222:Triamcinolone Acetonide / Q000493:pharmacokinetics*
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D005079:Excipients; D011145:Polyvinyls; D011480:Protease Inhibitors; C006912:carboxypolymethylene; D020442:Poloxamer; D014222:Triamcinolone Acetonide