[Protective action of Acanthopanax giraldii harms polysaccharides against experimental liver injury in rats and mice].
The experimental data indicate that Acanthopanax giraldii polysaccharides (AGP) significantly inhibit the elevation of serum ALT in CCl4-, D-galactosamine- and thioacetamide-intoxicated rats and mice. In CCl4-intoxicated mice, the retention of serum BSP was also reduced obviously by AGP. AGP was found to shorten the pentobarbital sleeping time in both normal and CCl4-intoxicated mice.
Dang
Y
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Department of Pharmacology, Lanzhou Medical College.
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000209:etiology; D005260:Female; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013448:Sulfobromophthalein
D011134:Polysaccharides; D013448:Sulfobromophthalein; D000410:Alanine Transaminase