[The electroencephalographic evolution of a group of patients on a ketonic diet].
BACKGROUND
A ketogenic diet is an old method for the treatment of resistant epilepsy in children, which has been revived in recent years because of its proven efficacy.


OBJECTIVE
To correlate electroencephalographic findings and clinical changes observed in a group of patients on the classical ketogenic diet, to determine the validity of the electroencephalogram in following-up treatment.


METHODS
We made a prospective evaluation of 11 patients aged between 1 and 19 years for an average period of 22 months. The patients had different types of resistant epilepsy according to Schmidt's score as modified by Aicardi, with a sleep encephalogram prior to treatment and 3, 6, 12 and 24 months later, after following the protocol of the classical ketogenic diet.


RESULTS
The sleep encephalograph recordings showed changes in all patients. In 9% of cases they became normal, there was great improvement in 45.45% and some improvement in 45.45%. No patient had worsening of the recording. There was over 50% reduction in the number of seizures seen in 72.7% of the children and complete control was achieved in 27.3%.


CONCLUSIONS
Normalization or improvement of sleep encephalogram recordings was correlated with improvement in seizures. Electroenchephalogram follow-up is a useful method for prediction of response to treatment with a ketogenic diet.
Panico
L R
LR
Centro Asistencial El Arbol, Santa Fe, Argentina. dietasur@hotmail.com
Ríos
V G
VG
Demartini
M G
MG
Carniello
M A
MA
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004032:Diet; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007657:Ketone Bodies / Q000096:biosynthesis*; D007662:Ketosis / Q000150:complications / Q000178:diet therapy*; D008297:Male; D012720:Severity of Illness Index
D007657:Ketone Bodies