Normal human plasma contains antibodies that specifically block neuropathy-associated human anti-GM1 IgG-antibodies.
Intravenous immunoglobulin (IVIg) is used in the treatment of a variety of autoimmune diseases. The blocking of disease-associated antibodies by anti-idiotype antibodies present in IVIg has been proposed as an action mechanism. Anti-GM1 antibodies have been implicated in motor neuropathies. Although IVIg is frequently applied for these diseases, the presence in IVIg or in human plasma of anti-idiotype antibodies that recognize anti-GM1 antibodies has not been clearly demonstrated. Here we present evidence that normal human plasma contains antibodies that inhibit the binding of anti-GM1 IgG-antibodies from neuropathy patients but do not inhibit anti-GM1 IgG-antibodies of rabbit origin with the same fine specificity. The significance of these findings in the course of acute and chronic neuropathies is discussed.
Lopez
P H
PH
Departamento de Química Biológica "Dr. Ranwel Caputto", Facultad de Ciencias Químicas, Universidad Nacional de Córdoba and CIQUIBIC, CONICET, 5000, Córdoba, Argentina.
Irazoqui
F J
FJ
Nores
G A
GA
D000328:Adult; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D005677:G(M1) Ganglioside / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D016472:Motor Neuron Disease / Q000276:immunology*; D011817:Rabbits
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G; D005677:G(M1) Ganglioside