title: Evidence of endothelium involvement in the pathophysiology of hydrops fetalis?
abstract: A fetus with signs of hydrops is at high risk of intrauterine death. The pathophysiology of hydrops fetalis is still unclear. We found decreased concentrations of cyclic guanosine monophosphate in fetal plasma of alloimmunized pregnancies complicated by hydrops fetalis, which might suggest reduced nitric oxide production due to injury of fetal vascular endothelial cells.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Leiden University Medical Center, Leiden, The Netherlands. cdegroot@knoware.nl
authors.forename: C J
authors.initials: CJ
authors.lastname: De Groot
authors.forename: D
authors.initials: D
authors.lastname: Oepkes
authors.forename: J
authors.initials: J
authors.lastname: Egberts
authors.forename: H H
authors.initials: HH
authors.lastname: Kanhai
mesh_terms: D000328:Adult; D003404:Creatinine / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D004730:Endothelium, Vascular / Q000166:cytology / Q000503:physiopathology*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005333:Fetus / Q000503:physiopathology*; D005353:Fibronectins / Q000097:blood; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D007124:Immunoenzyme Techniques; D010976:Platelet Count; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000503:physiopathology; D012709:Serum Albumin / Q000032:analysis
chemical_list: D005353:Fibronectins; D006454:Hemoglobins; D012709:Serum Albumin; D003404:Creatinine; D006152:Cyclic GMP