title: A review on the nonoperative removal of necrotic tissue from burn wounds.
abstract: The study of nonoperative debridement of burns got underway during the Second World War. A large number of substances such as enzymes of plant origin, acids and proteolytic enzymes of bacterial origin were examined since. The proteolytic enzymes derived from filtrates of C. histolyticum and B. subtilis have attracted the greatest interest. Although enzymatic debridement would seem at first sight to be an attractive form of treatment, unfortunately the results are highly variable.
authors.affiliation: University Hospital Groningen, Department of Surgery, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Klasen
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000150:complications / Q000473:pathology* / Q000628:therapy*; D002921:Cicatrix / Q000188:drug therapy* / Q000209:etiology; D002986:Clinical Trials as Topic; D003646:Debridement / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009336:Necrosis; D010447:Peptide Hydrolases / Q000627:therapeutic use; D011379:Prognosis; D019289:Pyruvic Acid / Q000627:therapeutic use; D011817:Rabbits; D013381:Subtilisins / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
chemical_list: C023177:sultilains; D019289:Pyruvic Acid; D010447:Peptide Hydrolases; D013381:Subtilisins