Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous system.
An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domain that restricts protease activity at the cell surface. Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development.
Jaworski
D M
DM
Department of Anatomy, University of Vermont College of Medicine, Given C454, Burlington, VT, USA. djaworsk@zoo.uvm.edu
D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D018076:DNA, Complementary / Q000235:genetics; D004790:Enzyme Induction; D005109:Extracellular Matrix / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D017403:In Situ Hybridization; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000096:biosynthesis* / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013116:Spinal Cord / Q000196:embryology / Q000201:enzymology
D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases; C492242:Mmp24 protein, rat