[Familial amyloid polyneuropathy type I complicated by chronic glaucoma: 3 cases].
OBJECTIVE
We report 3 cases of familial amyloid polyneuropathy type I (FAP) with amyloid infiltration of the vitreum and glaucoma.


METHODS
We reviewed the records of three patients, 2 females and one male, aged 41, 47 and 83 years respectively. The 3 patients had familial amyloid polyneuropathy type I with vitreous infiltration and open angle glaucoma. The two women underwent a liver graft four years earlier. Vitrectomy allowed confirmation of the diagnosis in the 83-year-old patient. Two patients underwent trabeculectomy, histological analysis of the iris and the trabeculum was obtained for one patient.


RESULTS
The tree patients presented a polyneuropathy, vitreous infiltration and open angle glaucoma. Results of light microscopy of the iris and the trabeculum showed amyloid deposits in the iris and the trabecular meshworks.


CONCLUSIONS
Familial amyloid polyneuropathy is a hereditary disease which may have a wide range of ocular manifestations. Glaucoma is among the most serious complications of familial amyloid polyneuropathy.
Frau
E
E
Service d'Ophtalmologie, CHU de Bicêtre, 78, avenue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.
Lautier-Frau
M
M
Saindelle-Ribeaudeau
F
F
Adams
D
D
Bousquet
A
A
Labétoulle
M
M
Offret
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017772:Amyloid Neuropathies / Q000150:complications* / Q000175:diagnosis; D002908:Chronic Disease; D003224:Congo Red; D005260:Female; D005901:Glaucoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D014130:Trabeculectomy; D014792:Visual Acuity
D003224:Congo Red