Antibody-mediated insulin resistance treated by cessation of insulin administration.
A 45-year-old Japanese man was referred to our hospital because of hyperglycemia despite the administration of as much as 120 U/day of human insulin. He had no history of injecting animal insulin. Free insulin was below 5 microU/ml, but a high titer of total insulin (about 3,000 microU/ml) was observed, suggesting the presence of antibodies against human insulin. Scatchard analysis showed an increased insulin binding capacity in the plasma characterized by a higher affinity for insulin. He was successfully treated by cessation of insulin administration. A Scatchard analysis series showed that a reduction in the insulin binding capacity of antibodies paralleled the improvement in glycemic control.
Hara
K
K
The Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo.
Tobe
K
K
Uchigata
Y
Y
Nakazono
M
M
Yasuda
K
K
Terauchi
Y
Y
Iwamoto
Y
Y
Akanuma
Y
Y
Kimura
S
S
Kadowaki
T
T
D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000276:immunology; D007328:Insulin / Q000008:administration & dosage* / Q000276:immunology; D007330:Insulin Antibodies / Q000097:blood* / Q000276:immunology; D007333:Insulin Resistance / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D007330:Insulin Antibodies