Acute basophilic leukemia presenting with abnormal liver function tests and the absence of blast cells in the peripheral blood.
Acute basophilic leukemia is an uncommon form of acute leukemia, rarely occurring as a de novo disease. We describe a case of de novo acute basophilic leukemia occurring in a 47-year-old man who presented with abnormal liver function tests in the absence of leukemic infiltration of the liver. We postulate that this presentation occurred as a consequence of pathophysiological features of the malignant basophilic blast cells.
Scolyer
R A
RA
Department of Anatomical Pathology, Canberra Hospital, Garran, ACT, Australia.
Brun
M
M
D'Rozario
J
J
Webb
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000473:pathology; D003561:Cytarabine / Q000627:therapeutic use; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D006801:Humans; D015255:Idarubicin / Q000627:therapeutic use; D016130:Immunophenotyping; D007621:Karyotyping; D015471:Leukemia, Basophilic, Acute / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D017254:Leukemic Infiltration / Q000473:pathology*; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D014411:Neoplastic Stem Cells / Q000473:pathology*
D003561:Cytarabine; D015255:Idarubicin