title: Novel peptidomimetic hematoregulatory compounds.
abstract: The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
authors.affiliation: Department of Medicinal Chemistry, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com
authors.forename: D A
authors.initials: DA
authors.lastname: Heerding
authors.forename: M
authors.initials: M
authors.lastname: Abruzzese
authors.forename: D
authors.initials: D
authors.lastname: Alberts
authors.forename: J
authors.initials: J
authors.lastname: Burgess
authors.forename: J F
authors.initials: JF
authors.lastname: Callahan
authors.forename: W F
authors.initials: WF
authors.lastname: Huffman
authors.forename: A G
authors.initials: AG
authors.lastname: King
authors.forename: S
authors.initials: S
authors.lastname: LoCastro
authors.forename: P
authors.initials: P
authors.lastname: DeMarsh
authors.forename: L M
authors.initials: LM
authors.lastname: Pelus
authors.forename: J S
authors.initials: JS
authors.lastname: Takata
authors.forename: P K
authors.initials: PK
authors.lastname: Bhatnagar
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D002177:Candidiasis / Q000188:drug therapy; D002317:Cardiovascular Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D002460:Cell Line; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000378:metabolism; D015195:Drug Design; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006133:Growth Substances / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D011955:Receptors, Drug / Q000737:chemistry / Q000187:drug effects
chemical_list: D000596:Amino Acids; D002317:Cardiovascular Agents; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors; C475895:Cxcl1 protein, mouse; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D011955:Receptors, Drug; D016179:Granulocyte Colony-Stimulating Factor; C086049:SK&F 107647; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor