title: [Bilateral malfunction of peripheral vestibular organs. Observations of 20 cases of Dandy syndrome].
abstract: BACKGROUND
  Dandy's Syndrome initially provokes dizziness and vertigo. Later on patients suffer from motion unsteadiness especially in dark surroundings and from oscillopsies. Gentamicin is ototoxic mostly for the vestibular part of the inner ear, and it is nephrotoxic. It may cause transitory renal dysfunction. Chronic or acute renal insufficiencies inhibit gentamicin clearance.
  
  
  METHODS
  Among 20 cases we found 15 who had previously been treated with aminoglycosides (13 with gentamicin and two with streptomycin). Ten of our patients showed symptoms of preexistant chronic nephrosis or of transitory renal insufficiency caused by gentamicin therapy. In all 13 cases, peripheral vestibular function was destroyed or severely damaged by antibiotic. The same patients had no hearing loss.
  
  
  CONCLUSIONS
  The different reactions of the cochlear and the vestibular end organs support the theoretical basis for transtympanic gentamicin treatment of Menière's disease.--Other reasons for Dandy's Syndrome were bilateral Menière's disease, skull fractures, and bilateral vestibular disorders.
authors.affiliation: HNO-Klinik Klinikum Wuppertal GmbH.
authors.forename: G
authors.initials: G
authors.lastname: Lange
authors.forename: R
authors.initials: R
authors.lastname: Keller
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003638:Deafness / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D013577:Syndrome; D015837:Vestibular Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D014722:Vestibule, Labyrinth / Q000187:drug effects / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins