[Physiological manifestations of action of a gene regulating predisposition to a pendulum-like movements in rodents].
Physiological effects of the gene determining predisposition to a stereotypical hyperkinesis in the form of pedulum movements (PM) are manifested in some behavioral peculiarities (total motor activity, emotionality, intensity of the startle reflex, sensitivity of the 5-HT2 receptors, predisposition to catalepsy). High frequency of the PM occurring in Wistar rat stock suggests that the gene determining the PM expression is not a pathological one but controls some adaptive properties of the nervous system. Relationships between the PM expression and the degree of predisposition to catalepsy are biphasic and may be described by an inverted U-shaped curve.
Kolpakov
V G
VG
Institue of Cytology and Genetics, Siberian Branch of the Russian Academy of Sci., 10 Pr. Lavrentieva, Novosibirsk 630090.
Alekhina
T A
TA
Barykina
N N
NN
Chuguĭ
V F
VF
Popova
N K
NK
D000161:Acoustic Stimulation; D000818:Animals; D002375:Catalepsy / Q000235:genetics; D003672:Defecation / Q000235:genetics; D006948:Hyperkinesis / Q000235:genetics; D009043:Motor Activity / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000235:genetics; D012641:Selection, Genetic; D013239:Stereotyped Behavior / Q000502:physiology*