title: Delayed onset of pulmonary hypertension associated with an appetite suppressant, mazindol: a case report.
abstract: The use of the appetite suppressant agents aminorex and fenfluramine derivatives has been reported as a risk factor for the development of pulmonary hypertension. A 29-year-old female developed pulmonary hypertension suspected to be due to an amphetamine-like appetite suppressant agent, mazindol ((+/-)-5-(p-chlorophenyl)-2,5-dihydro-3H-imidazo [2,1-a] isoindol-5-ol). She was admitted to Sapporo Medical University Hospital with dyspnea due to severe pulmonary hypertension. Twelve months prior to admission, she had taken mazindol continuously for a period of 10 weeks. As yet, her pulmonary hypertension has not completely improved. This is the first reported case of mazindol-associated pulmonary hypertension, which developed after a long latent interval, and it suggests that mazindol is also a risk factor for the development of pulmonary hypertension, making long-term follow-up necessary for patients taking this anorectic agent.
authors.affiliation: Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Hagiwara
authors.forename: A
authors.initials: A
authors.lastname: Tsuchida
authors.forename: M
authors.initials: M
authors.lastname: Hyakkoku
authors.forename: K
authors.initials: K
authors.lastname: Nishizato
authors.forename: T
authors.initials: T
authors.lastname: Asai
authors.forename: Y
authors.initials: Y
authors.lastname: Nozawa
authors.forename: K
authors.initials: K
authors.lastname: Tsuchihashi
authors.forename: K
authors.initials: K
authors.lastname: Shimamoto
mesh_terms: D000328:Adult; D000635:Aminorex / Q000009:adverse effects / Q000627:therapeutic use; D001067:Appetite Depressants / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000503:physiopathology; D008454:Mazindol / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D001067:Appetite Depressants; D000635:Aminorex; D008454:Mazindol