title: Inhibition of inducible nitric oxide synthase by acetamidine derivatives of hetero-substituted lysine and homolysine.
abstract: The synthesis and in vitro evaluation of the acetamidine derivatives of hetero-substituted lysine and homolysine analogues have identified potent inhibitors of human nitric oxide synthase enzymes, including examples with marked selectivity for the inducible isoform.
authors.affiliation: Glaxo Wellcome Research and Development, Stevenage, Hertfordshire, UK. rjy40958@glaxowellcome.co.uk
authors.forename: R J
authors.initials: RJ
authors.lastname: Young
authors.forename: R M
authors.initials: RM
authors.lastname: Beams
authors.forename: K
authors.initials: K
authors.lastname: Carter
authors.forename: H A
authors.initials: HA
authors.lastname: Clark
authors.forename: D M
authors.initials: DM
authors.lastname: Coe
authors.forename: C L
authors.initials: CL
authors.lastname: Chambers
authors.forename: P I
authors.initials: PI
authors.lastname: Davies
authors.forename: J
authors.initials: J
authors.lastname: Dawson
authors.forename: M J
authors.initials: MJ
authors.lastname: Drysdale
authors.forename: K W
authors.initials: KW
authors.lastname: Franzman
authors.forename: C
authors.initials: C
authors.lastname: French
authors.forename: S T
authors.initials: ST
authors.lastname: Hodgson
authors.forename: H F
authors.initials: HF
authors.lastname: Hodson
authors.forename: S
authors.initials: S
authors.lastname: Kleanthous
authors.forename: P
authors.initials: P
authors.lastname: Rider
authors.forename: D
authors.initials: D
authors.lastname: Sanders
authors.forename: D A
authors.initials: DA
authors.lastname: Sawyer
authors.forename: K J
authors.initials: KJ
authors.lastname: Scott
authors.forename: B G
authors.initials: BG
authors.lastname: Shearer
authors.forename: R
authors.initials: R
authors.lastname: Stocker
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: M C
authors.initials: MC
authors.lastname: Tackley
authors.forename: R G
authors.initials: RG
authors.lastname: Knowles
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II; D009952:Ornithine / Q000031:analogs & derivatives / Q000494:pharmacology; D013440:Sulfides / Q000494:pharmacology; D013450:Sulfones / Q000494:pharmacology
chemical_list: D000081:Acetamides; D004791:Enzyme Inhibitors; C409003:GW 273629; D007202:Indicators and Reagents; D007527:Isoenzymes; D013440:Sulfides; D013450:Sulfones; C409004:GW 274150; D009952:Ornithine; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D008239:Lysine