Gamma(delta) T cells: non-classical ligands for non-classical cells.
A recent study describes direct binding between a gammadelta T-cell receptor and its ligand, T22, a non-classical class I major histocompatibility complex (MHC) molecule. A companion study, solving the crystal structure of T22, highlights the differences between this interaction and those of classical MHC molecules and alphabeta T cells.
Steele
C R
CR
Department of Immunobiology, GKT School of Medicine, Guy's Hospital, London, SE1 9RT, UK.
Oppenheim
D E
DE
Hayday
A C
AC
D003461:Crystallography; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism*; D018448:Models, Immunological; D008958:Models, Molecular; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D011506:Proteins; D016692:Receptors, Antigen, T-Cell, gamma-delta; C089395:T22 antigen