Collagenous colitis: a long-term follow-up study.
OBJECTIVE
Collagenous colitis was first described in 1976. It is a rare disorder and the long-term course and prognosis of the disease are unknown. The aim of this study was to evaluate the course of the disease more than 5 years after the diagnosis.


METHODS
A retrospective follow-up of patients with collagenous colitis diagnosed during the period 1979-1990.


METHODS
All examinations performed at the time of diagnosis were reviewed and the clinical courses of the patients were determined by evaluation of the medical records. At a follow-up visit in 1996 complete histories were obtained and conventional laboratory tests were performed.


RESULTS
Two men and 22 women aged 20-82 years with collagenous colitis were identified. At the time of diagnosis, extensive investigation did not reveal other gastrointestinal diseases. At the time of follow-up, six patients had died from diseases unrelated to collagenous colitis, 10 patients suffered from chronic or intermittent diarrhoea, and four patients had been without gastrointestinal symptoms for the last 2-10 years. None of the patients developed colorectal cancer or chronic inflammatory bowel disease. Four patients were lost to follow-up.


CONCLUSIONS
Collagenous colitis is a benign disease, most often with a chronic course. No association with other gastrointestinal diseases was found.
Bonderup
O K
OK
Department of Medical Gastroenterology, Aalborg Hospital, Denmark.
Folkersen
B H
BH
Gjersøe
P
P
Teglbjaerg
P S
PS
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003092:Colitis / Q000150:complications / Q000473:pathology*; D003094:Collagen / Q000378:metabolism; D003106:Colon / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D003094:Collagen