Chemical stability of nucleic acid-derived drugs.
Nucleic acid-derived drugs exhibit both chemical and physical instability. This mini-review focuses on the prevalent hydrolytic and oxidative pathways of chemical degradation as they are affected by various endogenous (primary structure, chemical modifications in bases, sugars and phosphate residues) and exogenous (pH, buffer concentration, metal cation presence, oxygen presence) factors.
Pogocki
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Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Schöneich
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C
D015195:Drug Design; D006868:Hydrolysis; D009696:Nucleic Acids / Q000737:chemistry*; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis* / Q000737:chemistry
D009696:Nucleic Acids; D004364:Pharmaceutical Preparations