[Effect of hydrocortisone on composition of polyphosphoinositides in liver cell nuclear membrane and rat brain].
The action of hydrocortisone in vivo was shown to cause changes both in the total amount of phospholipids and polyphosphoinositides of rat liver and brain nuclear membranes. The hormone increased the content of five from seven phospholipid fractions including the fraction of monophosphoinositide when acting in concentration and exposition leading to activation of biosynthetic processes. The increasing of monophosphoinositides amount was accompanied by the decreasing of triphosphoinositides content which indicated the redistribution among the phosphoinositides fractions under the steroid hormone action in both cell types.
Gevorkian
E S
ES
Yerevan State University, Armenia.
Iavroian
Zh V
ZhV
Artsruni
I G
IG
Demirkhanian
L O
LO
Akopian
N R
NR
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009685:Nuclear Envelope / Q000187:drug effects* / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats
D018129:Phosphatidylinositol Phosphates; D006854:Hydrocortisone