A highly convergent approach to O- and N-linked glycopeptide analogues.
Deprotected C-glycopyranosyl-ketones have been conjugated by a chemoselective approach to a peptide or an amino acid bearing an aminooxy group on the N-terminus or on the side-chain, respectively. The coupling reaction, performed in aqueous media, does not require protecting groups on the peptide or saccharide moieties, nor auxiliary coupling reagents.
Peri
F
F
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milano.
Cipolla
L
L
La Ferla
B
B
Dumy
P
P
Nicotra
F
F
D000595:Amino Acid Sequence; D006020:Glycopeptides / Q000737:chemistry*; D008969:Molecular Sequence Data; D011487:Protein Conformation
D006020:Glycopeptides