title: Tubulointerstitial nephritis associated with Legionnaires' disease.
abstract: A 47-year-old man was admitted to our hospital for community-acquired pneumonia complicated with acute renal failure. Legionella pneumophila serogroup type 1 was grown in BCYE (buffered charcoal yeast extract) agar for sputum culture. Although his respiratory illness responded to intravenous erythromycin therapy, renal failure worsened and necessitated hemodialysis. Renal biopsy showed profound tubulointerstitial nephritis. After initiation of steroid therapy his renal function improved and he was discharged thereafter. These findings suggest that in Legionnaires' disease with acute renal failure, tubulointerstitial nephritis should also be considered and steroid therapy may be an effective modality for the renal complication.
authors.affiliation: Iwao Hospital, Kutukichou, Kagoshima.
authors.forename: K
authors.initials: K
authors.lastname: Nishitarumizu
authors.forename: Y
authors.initials: Y
authors.lastname: Tokuda
authors.forename: H
authors.initials: H
authors.lastname: Uehara
authors.forename: M
authors.initials: M
authors.lastname: Taira
authors.forename: K
authors.initials: K
authors.lastname: Taira
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007684:Kidney Tubules / Q000648:ultrastructure; D016952:Legionella pneumophila / Q000276:immunology / Q000302:isolation & purification; D007877:Legionnaires' Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial; D005938:Glucocorticoids; D011239:Prednisolone