Evidence of a major gene effect for angiotensinogen among Nigerians.
To dissect the genetic pathway of hypertension, we measured angiotensinogen in 685 members of 186 families recruited from a rural community in southwest Nigeria. Commingling and segregation analyses were carried out. A mixture of two and/or three distributions fits the data significantly better than a single distribution in commingling analysis, suggesting a major gene effect. Segregation analysis confirmed that a recessive major gene model for low values of angiotensinogen provides the best fit to the data and about 13% of the variance was due to the recessive gene segregation.
Guo
X
X
Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA.
Rotimi
C
C
Cooper
R
R
Luke
A
A
Elston
R C
RC
Ogunbiyi
O
O
Ward
R
R
D000293:Adolescent; D000328:Adult; D000808:Angiotensinogen / Q000097:blood / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009549:Nigeria / Q000453:epidemiology; D012424:Rural Population
D000808:Angiotensinogen