Neurotransmitter dysfunction in patients with borderline personality disorder.
Neurotransmitter system dysfunction may contribute to the borderline personality disorder traits of impulsive aggression and affective instability. This article reviews evidence from neurochemical assays, receptor-density studies, neuroendocrine-challenge paradigms, functional neuroimaging studies, and candidate-gene research, which converge to identify particular neurotransmitter systems that seem to be dysregulated in patients with borderline personality disorder.
Gurvits
I G
IG
Mount Sinai School of Medicine, New York, USA.
Koenigsberg
H W
HW
Siever
L J
LJ
D000109:Acetylcholine / Q000378:metabolism; D000339:Affect; D000374:Aggression; D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism; D001883:Borderline Personality Disorder / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000378:metabolism*; D006801:Humans; D007175:Impulsive Behavior / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018377:Neurotransmitter Agents; D001127:Arginine Vasopressin; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D009638:Norepinephrine