Differential effects of quinolinic acid lesions of the medial prefrontal cortex on the expression of morphine- and dizocilpine- induced behavioural plasticity in the rat.
Development and expression of behavioural sensitization have been shown to be differentially affected by drugs and lesions. Here we assessed the effects of quinolinic acid lesions of the rat medial prefrontal cortex on the expression of enhanced locomotion and rearing that has been induced prior to the lesions by 14 daily injections of morphine (10 mg/kg), dizocilpine (MK-801) (0.3 mg/kg) or the combination of both drugs. Expression of tolerance to morphine-induced behavioural inhibition was blocked by the lesions while the expression of MK-801 -induced sensitization was not affected and the expression of the sensitization induced by the drug combination was only mildly attenuated. These results suggest that the expression of behavioural plasticity induced by different drugs is mediated at least in part by different neural substrates.
Tzschentke
T M
TM
Department of Neuropharmacology, Zoological Institute, University of Tübingen, Mohlstrasse, Germany. thomas.tzschentke@grunenthal.com
Schmidt
W J
WJ
D000704:Analysis of Variance; D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004347:Drug Interactions; D004361:Drug Tolerance; D005163:Factor Analysis, Statistical; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D017378:Quinolinic Acid / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016291:Dizocilpine Maleate; D009020:Morphine; D017378:Quinolinic Acid