title: Pulmonary hemodynamics contribute to indicate priority for lung transplantation in patients with cystic fibrosis.
abstract: OBJECTIVE
  Lung transplantation is a viable option for patients with cystic fibrosis. The current strategy of selection, based on spirometry and deterioration of quality of life, results in a high mortality on the waiting list. We reviewed the case histories of patients with cystic fibrosis accepted for lung transplantation to ascertain whether pulmonary hemodynamics could contribute to predict life expectancy.
  
  
  METHODS
  Forty-five patients with cystic fibrosis were accepted: 11 died on the waiting list (group I), 24 underwent transplantation (group II), and 10 are still waiting (group III). During evaluation we recorded spirometry, oxygen requirement, ratio of arterial oxygen tension to inspired oxygen fraction (PaO (2)/FIO (2)), arterial carbon dioxide tension (PaCO (2)), 6-minute walk test results, right ventricular ejection fraction, echocardiography, and pulmonary hemodynamics. We compared data from group I, II, and III patients. A comparison was also made within group II between the data collected at the time of evaluation and at the time of transplantation to quantify the deterioration during the waiting time.
  
  
  RESULTS
  The waiting time, spirometry, 6-minute walk test results, and right ventricular ejection fraction did not differ among the three groups. A statistically significant difference was found for PaO (2)/FIO (2), PaCO (2), mean pulmonary artery pressure, cardiac index, pulmonary arterial wedge pressure, and intrapulmonary shunt between groups I and II. Groups I and III showed statistically significant differences for mean pulmonary artery pressure, PaO (2)/FIO (2), and systemic vascular resistance indexed. No differences were observed between groups II and III. The comparison within group II showed a significant deterioration of pulmonary hemodynamics during the waiting time.
  
  
  CONCLUSIONS
  Pulmonary hemodynamics are worst in patients dying on the waiting list and deteriorate significantly during the waiting time. They may thus contribute to establish priority for lung transplantation in patients with cystic fibrosis.
authors.affiliation: University of Rome La Sapienza, Departments of Thoracic Surgery, Rome, Italy. Fevenuta@tin.it
authors.forename: F
authors.initials: F
authors.lastname: Venuta
authors.forename: E A
authors.initials: EA
authors.lastname: Rendina
authors.forename: G D
authors.initials: GD
authors.lastname: Rocca
authors.forename: T
authors.initials: T
authors.lastname: De Giacomo
authors.forename: F
authors.initials: F
authors.lastname: Pugliese
authors.forename: A M
authors.initials: AM
authors.lastname: Ciccone
authors.forename: C D
authors.initials: CD
authors.lastname: Vizza
authors.forename: G F
authors.initials: GF
authors.lastname: Coloni
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002648:Child; D003550:Cystic Fibrosis / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D010100:Oxygen / Q000097:blood; D018579:Patient Selection; D011652:Pulmonary Circulation; D011659:Pulmonary Gas Exchange; D013147:Spirometry; D013318:Stroke Volume; D014655:Vascular Resistance; D014850:Waiting Lists
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen