[Postradiation changes in the brain asymmetry and higher mental functions of right- and left-handed subjects (the sequelae of the accident at the Chernobyl Atomic Electric Power Station)].
The present study was aimed at comparative electrophysiological, clinical, and neurophysiological assessment of the brain functional state in dextrals (50 men) and sinistrals (5 men), who participated in the Chernobyl clean. The patients were observed over the course of 10 years (from 1990 to 1999). The results of examination of healthy persons (20 dextrals and 10 sinistrals) were used as a control. The clinical examination revealed the earlier manifestation and more severe development of paroxysmal and epileptic seizures in sinistrals than in dextrals. Electrophysiological study showed a progressive decrease in interhemispheric asymmetry of the EEG coherence characteristic for a healthy brain to inversion of its sign. These changes were more pronounced in sinistrals. In the remote terms after radiation, the interhemispheric EEG coherence decreased over the whole cortex, especially, in the frontal and central areas in both groups of patients. Neurophysiological study revealed a progressive impairment of voluntary motor activity and tactile sensibility, especially, in the left hand. These defects were more expressed in sinistrals than in dextrals. The results of complex and longitudinal examination suggest that the observed changes in brain asymmetry and interhemispheric interaction can be not only a result of a dysfunction of subcortical limbic-reticular and mediobasal brain structures but also a result of the white matter damage including corpus callosum. More expressed impairments in sinistrals than in dextrals can be explained by specific morphofunctional organization of the brain in persons with different sensor and motor asymmetries.
Zhavoronkova
L A
LA
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Gogitidze
N V
NV
Kholodova
N B
NB
D000328:Adult; D004292:Dominance, Cerebral / Q000502:physiology / Q000528:radiation effects*; D004569:Electroencephalography / Q000379:methods / Q000528:radiation effects / Q000706:statistics & numerical data; D004594:Electrophysiology; D006613:Higher Nervous Activity / Q000502:physiology / Q000528:radiation effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011210:Power Plants; D018788:Radioactive Hazard Release; D018709:Statistics, Nonparametric; D013997:Time Factors; D014455:Ukraine