title: Presence of cholinesterases in Echinococcus granulosus protoscolices.
abstract: Cholinesterases were detected in protoscolices of Echinococcus granulosus spectrophotometrically and electrophoretically. To characterize these activities as acetylcholinesterases or pseudocholinesterases, BW284C51 and the organophosphate anthelmintic Neguvón were assayed as specific inhibitors of acetylcholinesterases, while Iso-OMPA was employed as specific inhibitor of pseudocholinesterases. We concluded that these cholinesterase (ChE) activities would be considered as possible targets in chemotherapy.
authors.affiliation: Laboratory of Parasitology, Faculty of Pharmacy, University of Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Giménez-Pardo
authors.forename: R M
authors.initials: RM
authors.lastname: Ros Moreno
authors.forename: C
authors.initials: C
authors.lastname: De Armas-Serra
authors.forename: F
authors.initials: F
authors.lastname: Rodríguez-Caabeiro
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D002802:Cholinesterases / Q000378:metabolism*; D004446:Echinococcus / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D014236:Trichlorfon / Q000494:pharmacology
chemical_list: D000871:Anthelmintics; D002800:Cholinesterase Inhibitors; D002093:Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; D014236:Trichlorfon; D000110:Acetylcholinesterase; D002802:Cholinesterases