title: Longitudinal study of adaptation to the stress of bone marrow transplantation.
abstract: OBJECTIVE
  This prospective longitudinal study of adaptation to bone marrow transplantation (BMT) addressed three questions: (1) When during BMT do individuals experience the greatest distress? (2) What factors are associated with this distress? (3) Are there variables that could be potential clinical indicators of persons in greatest need of preventive intervention?
  
  
  METHODS
  One hundred one participants undergoing either an autologous or allogeneic BMT completed questionnaires before hospitalization, before bone marrow infusion, 7 days and 14 days after transplantation, and then 1 month, 3 months, and 12 months after hospitalization. Adaptation was indicated by the degree of emotional distress. Independent variables were personal control, social support from specific sources, cognitive response, self-perception, and coping strategies, controlling for symptomatology.
  
  
  RESULTS
  The greatest emotional distress occurred after admission to the hospital and before the bone marrow infusion. Anxiety and depression decreased 1 week after the transplant, although symptomatology increased during this time. The periods of least emotional distress were 3 months and 1 year after transplantation. Factors that accounted for the greatest variance in emotional distress/adaptation were the degree of emotional distress at baseline, personal control, cognitive response, and symptomatology.
  
  
  CONCLUSIONS
  According to this longitudinal study, which includes pretransplant data, data from in-hospital transplantation, and posttransplant data, (1) psychosocial vulnerability of these BMT recipients was greatest during hospitalization before the transplant, (2) perceived personal control may be a potential indicator of vulnerability to secondary psychosocial morbidity, and (3) the demonstrated significance of psychosocial well-being before BMT indicates the importance of obtaining prospective data for both research and clinical purposes.
authors.affiliation: Indiana University School of Nursing, Indiana University Cancer Center, Indiananapolis, USA. iuoq700@iupui.edu
authors.forename: B L
authors.initials: BL
authors.lastname: Fife
authors.forename: G A
authors.initials: GA
authors.lastname: Huster
authors.forename: K G
authors.initials: KG
authors.lastname: Cornetta
authors.forename: V N
authors.initials: VN
authors.lastname: Kennedy
authors.forename: L P
authors.initials: LP
authors.lastname: Akard
authors.forename: E R
authors.initials: ER
authors.lastname: Broun
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D001007:Anxiety / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000523:psychology*; D003866:Depressive Disorder / Q000209:etiology; D005260:Female; D006760:Hospitalization; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000523:psychology / Q000628:therapy; D010351:Patient Discharge; D011446:Prospective Studies; D012944:Social Support; D013315:Stress, Psychological; D013997:Time Factors