Inhibitory actions of ropivacaine on tumor necrosis factor-alpha-induced leukocyte adhesion and tissue accumulation in vivo.
We have examined the effect of ropivacaine, a local anesthetic, on leukocyte-endothelium interactions induced by tumor necrosis factor-alpha (TNF-alpha) in vivo by the use of intravital microscopy in the mouse cremaster microcirculation. It was found that ropivacaine markedly reduced venular leukocyte adhesion and tissue recruitment in response to TNF-alpha challenge, whereas leukocyte rolling was unchanged. Thus, treatment with ropivacaine may be a useful pharmacological tool to control acute inflammation.
Zhang
X W
XW
Department of Surgery, Malmö University Hospital, Lund University, Malmö 20502, Sweden.
Thorlacius
H
H
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D019007:P-Selectin / Q000502:physiology; D000077212:Ropivacaine; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000577:Amides; D019007:P-Selectin; D014409:Tumor Necrosis Factor-alpha; D000077212:Ropivacaine