Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice.
This study was undertaken to investigate the effect of endogenous mu-receptor-selective peptide endomorphin 1, administered intracerebroventricularly, on oxygen consumption in mice. The intracerebroventricular injection of endomorphin 1 (3-30 nmol) significantly increased oxygen consumption in unrestrained mice. The effect of endomorphin 1 (30 nmol) was significantly antagonized by the simultaneous intraperitoneal administration of naloxone (100 nmol). These results suggest that endomorphin 1 stimulates oxygen consumption, and that the mu-opioid receptor influences energy balance in mice.
Asakawa
A
A
Second Department of Internal Medicine, Kobe University School of Medicine, Japan.
Inui
A
A
Ueno
N
N
Fujimiya
M
M
Fujino
M A
MA
Kasuga
M
M
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D002555:Cerebrospinal Fluid; D004435:Eating / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D017450:Receptors, Opioid, mu / Q000819:agonists*
D000701:Analgesics, Opioid; D009842:Oligopeptides; D017450:Receptors, Opioid, mu; C105293:endomorphin 1