title: Two-component and phosphorelay signal transduction.
abstract: Two-component and phosphorelay signal transduction systems are the major means by which bacteria recognize and respond to a variety of environmental stimuli. Recent results have implicated these systems in the regulation of a variety of essential processes including cell-cycle progression, pathogenicity, and developmental pathways. Elucidation of the structures of the interacting domains is leading to an understanding of the mechanisms of molecular recognition and phosphotransfer in these systems.
authors.affiliation: Division of Cellular Biology, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. hoch@scripps.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Hoch
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism* / Q000472:pathogenicity; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism*; D005809:Genes, Regulator / Q000502:physiology; D010766:Phosphorylation; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors; D011494:Protein Kinases