Improved controlled release study of lomustine.
Lomustine (CCNU) microcapsules was prepared by improved recoacervation method, then mixed microcapsules with 0.7% collagen swelling solution to prepare the emulsion, spreaded the emulsion on the plate to form membrane and cross-linked it, the membrane would be planted into body and was expected to release at steady speed. The concentration of CCNU and the CCNU content of microcapsules were measured by ultraviolet spectrophotometry to observe the release of CCNU be slow and constant, approach to 0-class release approximately.
Sun
Y
Y
Department of Biomaterials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Tianjin, P.R.China.
Zhou
H
H
Zhang
Q
Q
Wu
X
X
D020341:Absorbable Implants; D018906:Antineoplastic Agents, Alkylating / Q000493:pharmacokinetics; D002021:Buffers; D002214:Capsules / Q000737:chemistry; D003094:Collagen / Q000378:metabolism; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D008130:Lomustine / Q000493:pharmacokinetics*; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; D002021:Buffers; D002214:Capsules; D003692:Delayed-Action Preparations; D008130:Lomustine; D003094:Collagen