title: Brain SPECT imaging in Huntington's disease before and after therapy with olanzapine. Case report.
abstract: Olanzapine, an atypical antipsychotic drug, was administered to a patient with Huntington's disease (HD) with marked choreiform movements. Brain SPECT with 99mTc-HMPAO was performed before and after treatment. Brain SPECT imaging has been performed in patients with HD in order to determine the status of basal ganglia perfusion. The use of brain SPECT with 99mTc-HMPAO before and after treatment in patients with HD has not been yet reported. The marked hypoperfusion of the basal ganglia on brain SPECT performed before therapy with olanzapine improved significantly after treatment.
authors.affiliation: Department of Radiology, Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas (UNICAMP), Brazil. elba@mn-d.com
authors.forename: E C
authors.initials: EC
authors.lastname: Etchebehere
authors.forename: M C
authors.initials: MC
authors.lastname: Lima
authors.forename: W
authors.initials: W
authors.lastname: Passos
authors.forename: J A
authors.initials: JA
authors.lastname: Maciel Júnior
authors.forename: A O
authors.initials: AO
authors.lastname: Santos
authors.forename: C D
authors.initials: CD
authors.lastname: Ramos
authors.forename: E E
authors.initials: EE
authors.lastname: Camargo
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D014150:Antipsychotic Agents; D019275:Radiopharmaceuticals; D001569:Benzodiazepines; D019690:Technetium Tc 99m Exametazime; D010890:Pirenzepine; D000077152:Olanzapine