title: Evidence of a major gene effect for angiotensinogen among Nigerians.
abstract: To dissect the genetic pathway of hypertension, we measured angiotensinogen in 685 members of 186 families recruited from a rural community in southwest Nigeria. Commingling and segregation analyses were carried out. A mixture of two and/or three distributions fits the data significantly better than a single distribution in commingling analysis, suggesting a major gene effect. Segregation analysis confirmed that a recessive major gene model for low values of angiotensinogen provides the best fit to the data and about 13% of the variance was due to the recessive gene segregation.
authors.affiliation: Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, IL 60153, USA.
authors.forename: X
authors.initials: X
authors.lastname: Guo
authors.forename: C
authors.initials: C
authors.lastname: Rotimi
authors.forename: R
authors.initials: R
authors.lastname: Cooper
authors.forename: A
authors.initials: A
authors.lastname: Luke
authors.forename: R C
authors.initials: RC
authors.lastname: Elston
authors.forename: O
authors.initials: O
authors.lastname: Ogunbiyi
authors.forename: R
authors.initials: R
authors.lastname: Ward
mesh_terms: D000293:Adolescent; D000328:Adult; D000808:Angiotensinogen / Q000097:blood / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D009549:Nigeria / Q000453:epidemiology; D012424:Rural Population
chemical_list: D000808:Angiotensinogen