title: Spontaneous sustained monomorphic ventricular tachycardia after administration of ajmaline in a patient with Brugada syndrome.
abstract: We present the case of a 13-year-old boy with an episode of aborted sudden death, absence of structural heart disease, and a characteristic ECG pattern of right bundle branch block with persistent ST-segment elevation in the right precordial leads, in whom a monomorphic sustained ventricular tachycardia developed spontaneously after the administration of ajmaline. This effect may be related to an increased inhomogeneity of repolarization mediated by the drug and demonstrates the arrhythmogenic potential of Class I antiarrhythmic drugs in patients with Brugada syndrome.
authors.affiliation: Department of Cardiology, University Hospital Virgen de la Arrixaca, Murcia, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Pinar Bermúdez
authors.forename: A
authors.initials: A
authors.lastname: García-Alberola
authors.forename: J
authors.initials: J
authors.lastname: Martínez Sánchez
authors.forename: J J
authors.initials: JJ
authors.lastname: Sánchez Muñoz
authors.forename: M
authors.initials: M
authors.lastname: Valdés Chávarri
mesh_terms: D000293:Adolescent; D000404:Ajmaline / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D002037:Bundle-Branch Block / Q000188:drug therapy*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D013577:Syndrome; D017180:Tachycardia, Ventricular / Q000139:chemically induced* / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000188:drug therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D000404:Ajmaline