Foreign protein production in plant tissue cultures.
Foreign proteins synthesised by plants are now in the marketplace, and clinical trials for plant-derived therapeutic proteins are underway. Economic analysis of plant production systems has helped identify the types of protein that would be most suitable for manufacture using tissue culture methods. The major advantages associated with in vitro plant systems include the ability to manipulate environmental conditions for better control over protein levels and quality, the rapidity of production compared with agriculture, and the use of simpler and cheaper downstream processing schemes for product recovery from the culture medium.
Doran
P M
PM
Department of Biotechnology, University of New South Wales, Sydney, NSW 2052, Australia. p.doran@unsw.edu.au
D000383:Agriculture / Q000379:methods; D000818:Animals; D046508:Culture Techniques / Q000379:methods; D006031:Glycosylation; D006801:Humans; D010330:Patents as Topic; D059828:Plant Cells; D063245:Plant Development; D010944:Plants / Q000235:genetics* / Q000378:metabolism*; D030821:Plants, Genetically Modified / Q000235:genetics; D011499:Protein Processing, Post-Translational; D011786:Quality Control; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D015203:Reproducibility of Results; D019076:Transgenes / Q000235:genetics*
D011994:Recombinant Proteins