title: Multivariate methods in developing an evolutionary strategy for tablet formulation.
abstract: The aim of this study was to develop a new strategy for choosing excipients in tablet formulation. Multivariate techniques such as principal component analysis (PCA) and experimental design were combined in a multivariate design for screening experiments. Of a total 87 investigated excipients, the initial screening experiments contained 5 lubricants, 9 binders, and 5 disintegrants, and 35 experiments were carried out. Considering a reduced factorial design was used, the resulting PCA and partial least squares (PLS) models offered good insight into the possibilities of tablet formulation. It also offered solutions to the problems and clearly gave directions for optimum formulations. Further, it offered several alternatives for achieving quality formulations. Additional experiments conducted to validate and verify the usefulness of the model were successful, resulting in several tablets of good quality. The conclusion is that a multivariate strategy in tablet of formulation is efficient and can be used to reduce the number of experiments drastically. Combining multivariate characterization, physicochemical properties, experimental design, multivariate design, and PLS would lead to an evolutionary strategy for tablet formulation. Since it includes a learning strategy that continuously incorporates data for new compounds and from conducted experiments, this would be an even more powerful tool than expert systems.
authors.affiliation: Pharmacia and Upjohn, Structure-Property Optimization Center, Uppsala, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Gabrielsson
authors.forename: A
authors.initials: A
authors.lastname: Nyström
authors.forename: T
authors.initials: T
authors.lastname: Lundstedt
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003657:Decision Making; D006801:Humans; D015999:Multivariate Analysis; D012107:Research Design; D013607:Tablets
chemical_list: D013607:Tablets