Preliminary evaluation of cytotoxic properties of Raphia hookeri fruit mesocarp.
The aqueous and n-butanol fractions of the methanolic extract of Raphia hookeri fruit mesocarp was evaluated for cytotoxic properties using three different bioassays. The n-butanol fraction exhibited greater cytotoxicity than the aqueous fraction when tested against brine shrimp, mosquito larvae, and 5-day old tadpoles, the cytotoxicity towards the tadpoles being the most pronounced (LC(50)=0.83 ppm).
Obuotor
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Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
Onajobi
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D000818:Animals; D001156:Artemia / Q000187:drug effects*; D002025:Bufonidae; D003465:Culex / Q000187:drug effects*; D005638:Fruit; D007814:Larva / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D010946:Plants, Medicinal
D010936:Plant Extracts