Solid phase synthesis of diamides as potential bone resorption inhibitors.
Unsymmetrical diamide libraries have been prepared by a general and versatile solid phase route, using diacid templates in combination with aromatic and aliphatic amines chosen with the help of statistical experimental design. The compounds were tested as potential inhibitors of osteoclast vacuolar ATPase.
Edvinsson
K M
KM
Preclinical R&D, AstraZeneca R&D Mölndal, Sweden. karin.edvinsson@karobio.se
Herslöf
M
M
Holm
P
P
Kann
N
N
Keeling
D J
DJ
Mattsson
J P
JP
Nordén
B
B
Shcherbukhin
V
V
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D002645:Chickens; D016208:Databases, Factual; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D010010:Osteoclasts / Q000187:drug effects / Q000201:enzymology; D013698:Templates, Genetic
D000577:Amides; D004791:Enzyme Inhibitors; D000251:Adenosine Triphosphatases