Analysis of potassium counter ion and inorganic cation impurities in pharmaceutical drug substance by capillary electrophoresis with conductivity detection.
Capillary electrophoresis with conductivity detection is a selective and quantitative method for the analysis of counter cations, such as potassium, in pharmaceutical drug substances. It is also a sensitive and specific technique for screening and measuring inorganic impurities in drug substance samples. Both counter ion and inorganic impurities can be measured in the same test.
Williams
R C
RC
The DuPont Pharmaceuticals Company, Pharmaceutical Research and Development, Experimental Station, Wilmington, DE 19880-0353, USA.
Boucher
R J
RJ
D000578:Amidines / Q000032:analysis; D002138:Calibration; D002412:Cations / Q000737:chemistry*; D003404:Creatinine; D043844:Crown Ethers; D004340:Drug Contamination; D004553:Electric Conductivity; D019075:Electrophoresis, Capillary; D017341:Etanidazole / Q000032:analysis; D004988:Ethers, Cyclic; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000032:analysis; D019808:Losartan / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011188:Potassium / Q000737:chemistry*; D013054:Spectrophotometry, Atomic
D000578:Amidines; D002412:Cations; D043844:Crown Ethers; D004988:Ethers, Cyclic; D007202:Indicators and Reagents; D007555:Isoxazoles; D004364:Pharmaceutical Preparations; D017341:Etanidazole; C015762:18-crown-6; D003404:Creatinine; D019808:Losartan; C118235:roxifiban; D011188:Potassium