title: Covalent tethering of ligands to retinal rod cyclic nucleotide-gated channels: binding site structure and allosteric mechanism.
authors.affiliation: Department of Physiology and Biophysics, University of Colorado School of Medicine, Denver 80262, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Karpen
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
authors.forename: R L
authors.initials: RL
authors.lastname: Brown
mesh_terms: D000345:Affinity Labels; D000494:Allosteric Regulation; D000557:Ambystoma; D000818:Animals; D001386:Azides / Q000138:chemical synthesis / Q000493:pharmacokinetics; D001665:Binding Sites; D002417:Cattle; D006152:Cyclic GMP / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000493:pharmacokinetics; D054815:Cyclic Nucleotide-Gated Cation Channels; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005136:Eye Proteins / Q000737:chemistry / Q000378:metabolism; D006160:Guanosine Triphosphate; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D010446:Peptide Fragments / Q000737:chemistry / Q000302:isolation & purification; D010761:Phosphorus Radioisotopes; D011865:Radioisotope Dilution Technique; D011894:Rana pipiens; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*
chemical_list: D000345:Affinity Labels; D001386:Azides; D054815:Cyclic Nucleotide-Gated Cation Channels; D005136:Eye Proteins; D007473:Ion Channels; D008024:Ligands; D010446:Peptide Fragments; D010761:Phosphorus Radioisotopes; C081534:8-(4-azidophenacyl)thio-cyclic GMP; C016276:8-bromocyclic GMP; D006160:Guanosine Triphosphate; D006152:Cyclic GMP