DNA repair pathways and cancer prevention.
This article describes the five main classes of DNA repair processes that occur in humans with respect to their mechanism of action, major substrates, and role in protection against endogenous and environmental DNA damaging agents. The importance of all of these processes in protection from the initiation of neoplastic growth has been established either in studies of inheritable diseases affecting DNA repair or experiments with transgenic animals or both. The capacity of DNA repair pathways to deal with DNA damage is therefore a critical factor in the cellular response to environmental, and dietary carcinogens. DNA repair activity and factors affecting this activity either directly or indirectly must be taken into account in risk assessment.
Pegg
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Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033, USA.
D019883:Alkyl and Aryl Transferases / Q000378:metabolism; D024682:BRCA2 Protein; D004249:DNA Damage; D019175:DNA Methylation; D004260:DNA Repair; D019398:Genes, BRCA1; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics; D009369:Neoplasms / Q000517:prevention & control*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics
D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors; D011065:Poly(ADP-ribose) Polymerases; D019883:Alkyl and Aryl Transferases