[Effect of the long-term exposure of the isolated myometrium from nonpregnant rats to serum from pregnant women on its contractile activity and the beta-adrenergic reactivity].
Pregnant women's blood serum (the whole as well as 50- and 100-diluted) did not alter parameters of spontaneous motility, i.e. it did not affect the uterus myocytes' spontaneous motility, whereas the whole or 50-diluted serum raised considerable the rat myometrium's beta-adrenoreaction. The data obtained suggest that the beta-adrenoreaction of the rat uterus' myocytes increases after a prolonged contact with pregnant women's blood serum which may be due to the beta-adrenoreceptor synthesis activation and to an increase in their concentration because of diffusion from the blood serum. This suggests existence of humoral mechanisms of the myometrium beta-adrenoreaction regulation, the mechanisms creating the optimum uterus' contractile activity.
Sazanov
A V
AV
Viatka State Pedagogical University and Kirov State Medical Institute, 61002, Kirov, Lenin St., Russia.
Tsirkin
V I
VI
Dvorianskiĭ
S A
SA
D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001769:Blood / Q000378:metabolism*; D001790:Blood Physiological Phenomena; D004031:Diestrus / Q000502:physiology; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008686:Metestrus / Q000502:physiology; D009215:Myometrium / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014590:Uterine Contraction / Q000187:drug effects / Q000502:physiology*
D000318:Adrenergic beta-Agonists; D011943:Receptors, Adrenergic, beta; D004837:Epinephrine