title: Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures.
abstract: Lithospermum erythrorhizon cells cultured in pigment production (M-9) medium produced lithospermic acid B, a dimerized caffeic acid ester derivative, in quantities similar to the production of shikonin. The cells also produced a related dimer, (+)-rabdosiin. In Linsmaier-Skoog liquid medium, which suppresses shikonin production, both lithospermic acid B and (+)-rabdosiin were still formed. Lithospermic acid, a caffeic acid-rosmarinic acid conjugate, was isolated as a main constituent in Lithospermum hairy root cultures. In the aerial parts of L. erythrorhizon, the content of these phenylpropanoid oligomers was relatively low compared to that of rosmarinic acid.
authors.affiliation: Department of Pharmacognosy, Gifu Pharmaceutical University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Yazaki
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000378:metabolism; D002109:Caffeic Acids / Q000737:chemistry / Q000378:metabolism; D002478:Cells, Cultured; D053630:Depsides; D019281:Dimerization; D017705:Lignans; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000737:chemistry / Q000378:metabolism; D010944:Plants / Q000737:chemistry / Q000378:metabolism
chemical_list: D001572:Benzofurans; D002109:Caffeic Acids; D053630:Depsides; D017705:Lignans; D009285:Naphthoquinones; C115102:rabdosiin; C016101:shikonin; C076944:salvianolic acid B