title: Repellent and antifeedant activity of salicylic acid and related compounds against the biting midge, Culicoides impunctatus (Diptera: Ceratopogonidae).
abstract: An artificial membrane, blood-feeding method was used to assess the repellent and antifeedant effects of derivatives of salicylic acid on the biting midge Culicoides impunctatus Goetghebeur. Trans-2-hydroxycyclohexanecarboxylic acid, 6-methylsalicylic acid, 2,6-dihydroxy-4-methylbenzoic acid, and salicyluric acid caused highly significant inhibition of feeding, with salicyluric acid performing significantly greater than the other compounds. Investigating the effects of alkyl substitution of salicylic acid, o-thymotic and o-cresotic acids were also effective. A pilot clinical trial using salicyluric acid indicated that it provided a protective effect and it was hypothesized that this may have resulted primarily from contact, because no significant repellent effects were shown for this compound in a microscope slide test, designed to demonstrate repellency with volatile compounds.
authors.affiliation: Department of Pathology, Medical School, University of Newcastle upon Tyne, UK.
authors.forename: A E
authors.initials: AE
authors.lastname: Stuart
authors.forename: C J
authors.initials: CJ
authors.lastname: Brooks
authors.forename: R J
authors.initials: RJ
authors.lastname: Prescott
authors.forename: A
authors.initials: A
authors.lastname: Blackwell
mesh_terms: D000818:Animals; D002519:Ceratopogonidae; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007302:Insect Repellents; D012459:Salicylates
chemical_list: D007302:Insect Repellents; D012459:Salicylates