title: Sensitive detection of myocardial contraction abnormality in chronic hemodialysis patients by ultrasonic tissue characterization with integrated backscatter.
abstract: Since acoustic properties of the myocardium are sensitive to the myocardial structure and the contractile conditions of myocyte, the authors evaluated cardiac dysfunction based on the integrated ultrasonic backscatter in 18 hemodialysis (HD) patients (duration: 102 +/- 84 months, mean age: 57.6 +/- 9.7 years) and 11 age-matched normals. The cyclic variation of integrated backscatter (CV-IB) at interventricular septum (IVS) and left ventricular posterior wall (PW) was measured and compared with percent fractional shortening (%FS) and percent wall thickening (%Th). The CV-IB of HD patients was smaller than that of control subjects (IVS: 6.2 +/- 1.1 dB vs 8.2 +/- 1.1 dB, p = 0.0003 and PW: 8.4 +/- 2.2 vs 10.3 +/- 1.3, p= 0.025). No significant difference was observed in %FS and %Th between HD patients and control subjects. In HD, the ratio of velocities of early diastolic inflow (E) to late atrial inflow was decreased (0.7 +/- 0.2 vs 1.1 +/- 0.7, p = 0.049) and deceleration time of E was prolonged significantly (200 +/- 28 msec vs 159 +/- 30 msec, p = 0.0082). In the absence of overt cardiac systolic dysfunction, myocardial damage indicated as a decrease in CV-IB and diastolic dysfunction identified on transmitral velocity waveform were detected, which may reflect from the myocardial fibrosis. As a mechanism, pressure overload, hyperparathyroidism, and anemia were neglected, and the other humoral factors may contribute to the myocardial damage in chronic renal failure.
authors.affiliation: Second Department of Internal Medicine, Kagawa Medical University, Japan. katsumz@kms.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Mizushige
authors.forename: T
authors.initials: T
authors.lastname: Tokudome
authors.forename: M
authors.initials: M
authors.lastname: Seki
authors.forename: I
authors.initials: I
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Hirao
authors.forename: S
authors.initials: S
authors.lastname: Nozaki
authors.forename: S
authors.initials: S
authors.lastname: Miki
authors.forename: S
authors.initials: S
authors.lastname: Yuasa
authors.forename: H
authors.initials: H
authors.lastname: Matsuo
mesh_terms: D000368:Aged; D000740:Anemia / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D003131:Combined Modality Therapy; D015150:Echocardiography, Doppler / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric