[The effects of exogenous actin-binding casein kinase injected into the oocytes and ova of the clawed toad].
The effects of microinjections of exogenous casein kinase 2 on the structural organization of the maturing oocytes and eggs were studied in Xenopus laevis. Kinase inhibited the progesterone-stimulated oocyte maturation and induced dislocation of pigment granules. The morphological effect was shown to be dose-dependent. The results obtained are discussed in the light of the possible influence of casein kinase 2 on the organization of the cortical actin cytoskeleton through phosphorylation of actin-binding proteins.
Riabova
L V
LV
Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
Elizarov
S M
SM
Vasetskiĭ
S G
SG
D000199:Actins / Q000378:metabolism*; D000818:Animals; D047388:Casein Kinases; D003599:Cytoskeleton / Q000187:drug effects; D005260:Female; D007527:Isoenzymes / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D008845:Microinjections; D008854:Microscopy, Electron; D009865:Oocytes / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D010063:Ovum / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D011494:Protein Kinases / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D014982:Xenopus laevis
D000199:Actins; D007527:Isoenzymes; D011494:Protein Kinases; D047388:Casein Kinases