title: Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity.
abstract: The series of four dimers derived from head to tail coupling of the two enantiomers of the duocarmycin SA alkylation subunit are described.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. boger@scripps.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Boger
authors.forename: M
authors.initials: M
authors.lastname: Searcey
authors.forename: W C
authors.initials: WC
authors.lastname: Tse
authors.forename: Q
authors.initials: Q
authors.lastname: Jin
mesh_terms: D000478:Alkylation; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D004247:DNA / Q000187:drug effects; D000080890:Duocarmycins; D007211:Indoles; D007939:Leukemia L1210 / Q000188:drug therapy; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000080890:Duocarmycins; D007211:Indoles; D011758:Pyrroles; C066098:duocarmycin SA; D004247:DNA