Infection-resistant alloplasts.
Prosthesis-related infection accounts for nearly half of nosocomial infections, resulting in significant morbidity, mortality, prolonged hospitalization, and higher healthcare costs. Although numerous antimicrobial-coated surfaces have been suggested to guard against prosthesis-related infection, only a few, such as minocylcine plus rifampin, are clinically protective. The differences in clinical efficacy can be attributed at least in part to differences in the magnitude of leaching of the antimicrobial agent off the surface. There is a pressing need to explore the clinical efficacy of antimicrobial surfaces suitable for use in devices intended for long-term use.
Darouiche
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Department of Physical Medicine and Rehabilitation, Baylor College of Medicine and Veterans Affairs Medical Center, Houston, Texas 77030, USA. darouiche.rahab_o@houston.va.gov
D000818:Animals; D020099:Coated Materials, Biocompatible; D006801:Humans; D019736:Prostheses and Implants; D016459:Prosthesis-Related Infections / Q000517:prevention & control*; D013499:Surface Properties
D020099:Coated Materials, Biocompatible