Mannan-binding lectin concentration during normal human pregnancy.
Relative deficiency of mannan-binding lectin (MBL) is associated with recurrent miscarriage. To investigate whether MBL concentration alters as a result of pregnancy, serial measurements were made in 14 patients before and during normal early pregnancy. Additionally, a longitudinal study was made of one individual over several years and including two normal pregnancies. Three (20%) subjects experienced a significant increase in MBL concentration during pregnancy. It was concluded that a modest but significant increase in MBL concentration can result from pregnancy, but it is a rare occurrence in the first trimester.
Kilpatrick
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DC
Academic Unit, Department of Transfusion Medicine, 2 Forrest Road, Edinburgh EH1 2QN, UK.
D000026:Abortion, Habitual / Q000097:blood / Q000628:therapy; D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D037222:Collectins; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007962:Leukocytes / Q000276:immunology; D011247:Pregnancy
D002352:Carrier Proteins; D037222:Collectins