title: Heart rate variability, late potentials and QT dispersion as markers of myocardial involvement in patients with Behçet's disease.
abstract: BACKGROUND
  Myocardial involvement in Behçet's disease has been reported to be relatively rare.
  
  
  OBJECTIVE
  To evaluate myocardial involvement noninvasively in patients with Behçet's disease by measuring signal-averaged electrocardiography (SAECG), QT dispersion and heart rate variability (HRV).
  
  
  METHODS
  The study group comprised 28 eligible patients (16 male, mean age 37+/-13 years) of 33 patients with Behçet's disease, and 25 age- and sex-matched control subjects.
  
  
  RESULTS
  The echocardiographic left ventricular measurements were within normal limits and similar in both groups except the E/A ratio, which was significantly lower in patients with the disease than in control patients. Minimal pericardial effusion was detected in four patients. Considering the SAECG recordings, values of root mean square voltage in the last 40 ms were 30+/-18 microV and 38+/-18 microV in patients with Behçet's disease and in the control group, respectively. The number of cases with a value less than 20 microV was seven (25%) and one (4%) in the same groups, respectively. Both QT dispersion and the corrected QT interval dispersion were significantly increased in patients with Behçet's disease compared with the control patients (50.2+/-16.6 versus 20.4+/-18.8, P<0.01). Although all HRV measures appeared to be decreased in the Behçet's group, only the standard deviation of all filtered RR intervals in the entire 24 h ECG recordings and the percentage of differences between adjacent filtered RR intervals that are greater than 50 ms for the whole analysis values differed significantly between the groups (P<0.05). No significant difference was observed in frequency domain parameters. In the Holter ECG recording, grade 2 or greater premature ventricular complexes were observed in seven patients from the Behçet's group (25%) but in only one subject from the control group (4%) (P<0.05).
  
  
  CONCLUSIONS
  Patients with Behçet's disease appeared to have significantly increased QT dispersion, a left ventricular diastolic dysfunction pattern in echocardiography, a high incidence of positive late potentials and more complex ventricular arrhythmias, suggesting myocardial involvement and the existence of an arrhythmogenic substrate, whereas the HRV measures do not suggest a clear autonomic abnormality in Behçet's disease.
authors.affiliation: University School of Medicine, Izmir, Turkey. ozgurasl@superonline.com
authors.forename: O
authors.initials: O
authors.lastname: Kirimli
authors.forename: O
authors.initials: O
authors.lastname: Aslan
authors.forename: O
authors.initials: O
authors.lastname: Göldeli
authors.forename: S
authors.initials: S
authors.lastname: Güneri
authors.forename: O
authors.initials: O
authors.lastname: Badak
authors.forename: E
authors.initials: E
authors.lastname: Fetil
authors.forename: S
authors.initials: S
authors.lastname: Ozkan
mesh_terms: D000293:Adolescent; D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D018487:Ventricular Dysfunction, Left / Q000209:etiology