[The expression of P16, Rb and cyclin D1 and biological behavior of laryngeal cancer].
To determine the effect of gene of carcinorma on the proliferation and regulation in primary laryngeal cancer, P16, Rb, Cyclin D1 were examined with immunohistochemical SABC method in 36 cases of primary laryngeal cancer. The results showed: P16 was positive in 11 of 36 in carcinoma specimens (30.6%), 22 of 36 in the specimens surrounding the carcinoma (61.1%) were positive. The difference was significant (P < 0.05). The positive rates of Rb and Cyclin D1 were 61.1% and 47.2% respectively. Comparing the positive rate of P16 to Rb was more significantly (P < 0.05). In most circumstances, when Rb was positive, P16 was negative and vice versa. The positive rate of Rb correlated with the one of Cyclin D1 positively by rank correlation. The expression of P16 and Rb was significantly different between well and poor tissues differenciation. The expression had no significant difference in the same antibody in various clinical stage and position or in the same stage and position but different antibody. The results suggest that the feedback regulation chain consisted of P16 plays an important role in the proliferation and regulation.
Dai
S
S
P L A 463 Hospital, Shenyang.
Huang
W
W
Gan
X
X
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019938:Cyclin D1 / Q000096:biosynthesis; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis; D005260:Female; D015870:Gene Expression; D016161:Genes, Retinoblastoma; D019940:Genes, bcl-1; D019942:Genes, p16; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016160:Retinoblastoma Protein / Q000096:biosynthesis
D019941:Cyclin-Dependent Kinase Inhibitor p16; D016160:Retinoblastoma Protein; D019938:Cyclin D1