XE-CT CBF changes during normative aging, cognitive decline and dementia.
Factors accelerating cerebral degenerative changes represent potentially modifiable risks for cognitive decline. Putative risk factors accelerating mild cognitive decline and dementia were correlated with repeated measures of cerebral atrophy, CT densitometry, perfusions and cognitive testing among neurologically and cognitively normative volunteers. TIAs, hypertension, smoking and male gender accelerate cerebral degenerative changes, mild cognitive decline and dementia. Intervention by control of risk factors and cholinesterase inhibitors should prevent cerebral atropho-degenerative changes so that optimal cognitive performance is maintained.
Meyer
J S
JS
Cerebrovascular Research Laboratories, Veterans Administration Medical Center, Houston, TX, USA.
Rauch
G M
GM
Rauch
R A
RA
Haque
A
A
Crawford
K
K
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D003704:Dementia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D014978:Xenon
D014978:Xenon