title: Naloxone decreases tolerance to hypotensive, hypovolemic stress healthy humans.
abstract: OBJECTIVE
  In animal studies, naloxone, an opioid receptor antagonist, improves tolerance to hemorrhagic shock. The purpose of this study was to determine whether naloxone would augment tolerance to hypotensive hypovolemic stress (lower body negative pressure [LBNP]) in healthy human males.
  
  
  METHODS
  This study was a repeated measures design.
  
  
  METHODS
  The experiments were conducted in a laboratory setting.
  
  
  METHODS
  Eight healthy male subjects were tested. The subjects' ages were 30 +/- 4.0 yrs, height = 177 +/- 7.0 cm, and weight = 75.5 +/- 3.5 kg (mean +/- SEM).
  
  
  METHODS
  Subjects underwent two LBNP exposures terminated by the onset of vasodepression. At each of the exposures, using a double-blind procedure, the subjects received an intravenous injection of either saline placebo or naloxone in a dosage totaling 0.4 mg/kg.
authors.affiliation: Department of Health Promotion and Kinesiology, University of North Carolina, Charlotte 28223, USA. jtlightf@email.uncc.edu
authors.forename: J T
authors.initials: JT
authors.lastname: Lightfoot
authors.forename: L
authors.initials: L
authors.lastname: Katz
authors.forename: K
authors.initials: K
authors.lastname: DeBate
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001794:Blood Pressure; D004311:Double-Blind Method; D005542:Forearm / Q000098:blood supply; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D020896:Hypovolemia / Q000503:physiopathology*; D008150:Lower Body Negative Pressure; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D011446:Prospective Studies; D012039:Regional Blood Flow; D012771:Shock, Hemorrhagic / Q000188:drug therapy
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone