Predicting the time needed to achieve steady state if absorption and elimination constants are equal.
A simple table is derived to facilitate the rapid estimation of the number of dose administrations needed to achieve a certain fraction of the steady-state plasma concentration in the case of one-compartment model with uniform multiple oral dosing and equal absorption and elimination constants.
Singer
J
J
Chinoin Pharmaceutical and Chemical Works Ltd., Budapest, Hungary.
Vereczkey
L
L
D000042:Absorption; D000284:Administration, Oral; D006801:Humans; D007262:Infusions, Intravenous; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010599:Pharmacokinetics; D011237:Predictive Value of Tests; D013997:Time Factors