title: Prediction of creatinine clearance from serum creatinine in patients with rheumatoid arthritis: comparison of six formulae and one nomogram.
abstract: The estimation of glomerular filtration rate is important for the medical treatment of patients with rheumatoid arthritis (RA). However, the determination of endogenous creatinine clearance (Clcr) from a 24-h urine collection is an unreliable and time-consuming procedure. We therefore tested the accuracy of six equations and one nomogram for the prediction of Clcr from serum creatinine (Scr) in 38 patients with RA and 20 controls. A positive correlation was found for all methods in the controls (r = 0.83-0.94) and RA patients (r = 0.51-0.69). The methods did not overestimate Clcr in RA. In the RA group the simple formula published by Cockcroft [Clcr = ((140 - age) x body weight)/(72 x Scr), x 0.85 for females] showed the best correlation with the measured Clcr. In RA the Cockroft formula can reliably be used to predict Clcr from Scr.
authors.affiliation: Medizinische Poliklinik, Ludwig-Maximilians Universität Munich, Germany. hjanders@clinbio.med.uni-muenchen.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Anders
authors.forename: M
authors.initials: M
authors.lastname: Rihl
authors.forename: O
authors.initials: O
authors.lastname: Loch
authors.forename: M
authors.initials: M
authors.lastname: Schattenkirchner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood* / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D010045:Outpatients; D011237:Predictive Value of Tests; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D003404:Creatinine