[Coinfection with HIV and HTLV-I infection and survival in AIDS stage. French Guiana Study. GECVIG (Clinical HIV Study Group in Guiana)].
OBJECTIVE
The purpose of this study was to investigate the effect of HTLVI infection on survival in AIDS patients in French Guiana.


METHODS
A cohort of 151 adult patients with AIDS were followed from January 1992 through June 1996. Kaplan-Meier survival curves were established. Using the Cox model, multivariate analysis was performed to examine different factors affecting survival.


RESULTS
The incidence of HTLVI infection in this cohort was 11.9% and 57.6% of the patients died during the study period. Multivariate analysis disclosed that older age at diagnosis of AIDS (over 45 years) and low CD4 count (< 100/mm3) were predictors of poor survival. HIV-HTLVI co-infection was strongly correlated with reduced survival (p = 0.02; RR = 2.2; CI = 1.1-4.5).


CONCLUSIONS
In our region, all patients with HIV infection should be screened for HTLVI infection. In case of co-infection, early care should included adapted antiretroviral regimens.
Sobesky
M
M
Centre d'Information et de Soins de l'Immunodéficience humaine, CHG de Cayenne. sobeskym@nplus.gf
Couppie
P
P
Pradinaud
R
R
Godard
M C
MC
Alvarez
F
F
Benoît
B
B
Carme
B
B
Lebeux
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality; D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D015490:HTLV-I Infections / Q000150:complications* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate