title: Links between replication, recombination and genome instability in eukaryotes.
abstract: Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements.
authors.affiliation: Ludwig Institute for Cancer Research, Cancer Center and Dept of Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA.
authors.forename: H
authors.initials: H
authors.lastname: Flores-Rozas
authors.forename: R D
authors.initials: RD
authors.lastname: Kolodner
mesh_terms: D004249:DNA Damage; D004261:DNA Replication; D005057:Eukaryotic Cells; D016678:Genome; D011995:Recombination, Genetic