title: Imprint cytology in the diagnosis of Helicobacter pylori. Does imprinting damage the biopsy specimen?
abstract: OBJECTIVE
  To investigate the efficacy of imprint cytology in the diagnosis of Helicobacter pylori infection and whether it damages the biopsy specimen for subsequent histologic examination.
  
  
  METHODS
  Two antral biopsies were taken from 76 patients with dyspeptic symptoms undergoing upper gastrointestinal endoscopy. Imprint cytology was made from the first specimen. This specimen was fixed in 10% formalin and sent for histopathologic examination. The second specimen was directly fixed in 10% formalin for routine histopathologic examination without being used for an imprint. The imprint smears were examined by cytopathologists. The biopsy specimens were examined by pathologists who did not know which specimens were used for the imprints.
  
  
  RESULTS
  H pylori was seen in smears from 55 (72%) patients and in both biopsy specimens from the same patients. The pathologists could not recognize the biopsy specimens from which the imprints were made. Concordance between imprint cytology and histopathology was 100%.
  
  
  CONCLUSIONS
  Imprint cytology is a suitable test for H pylori diagnosis, and imprints do not adversely affect the quality of the biopsy specimen.
authors.affiliation: Department of General Surgery and Pathology, Kocaeli University Medical School, Izmit, Turkey. acubukcu@superonline.com
authors.forename: A
authors.initials: A
authors.lastname: Cubukçu
authors.forename: N N
authors.initials: NN
authors.lastname: Gönüllü
authors.forename: C
authors.initials: C
authors.lastname: Erçin
authors.forename: A
authors.initials: A
authors.lastname: Alponat
authors.forename: A C
authors.initials: AC
authors.lastname: Kaur
authors.forename: Z
authors.initials: Z
authors.lastname: Cantürk
authors.forename: N
authors.initials: N
authors.lastname: Paksoy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology; D013272:Stomach Diseases / Q000382:microbiology / Q000473:pathology*