Experimental study on the in vivo behaviour of a new collagen glue in lung surgery.
OBJECTIVE
To study the pneumostatic ability of a collagen polymerised with a polysaccharide (GAO) glue in lung surgery; its influence in pleuro-pulmonary adhesion formation; the pulmonary tissue reaction to it, its biodegradability, and the eventual alterations of pulmonary compliance induced by the glue.


METHODS
Two groups of ten rabbits (controls and treated) were operated under ventilatory assistance by thoracotomy to promote pleural adhesions, and injury to the lung. Repeated chest X-rays were carried out postoperatively. Lungs were examined histologically at day 40. In vitro tests were performed to study glue effects on pulmonary compliance.


RESULTS
Air leaks stopped 2 min after glue application. Persistent pneumothorax were likely seen in treated rabbits (ns). Glue induces a temporary reduction of pulmonary compliance. Glue did not increase adhesion formation, or interfere with the healing process.


CONCLUSIONS
For its properties, GAO seems to be a good and well-tolerated tool to reduce air leaks from the lung, without inducing residual pleural symphysis.
Feito
B A
BA
Department of Thoracic and Vascular Surgery, Avicenne Hospital, Bobigny, France. anatomie@smbh.univ-paris13.fr
Rath
A M
AM
Longchampt
E
E
Azorin
J
J
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003094:Collagen; D004195:Disease Models, Animal; D005260:Female; D006101:Granuloma, Giant Cell / Q000473:pathology; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008170:Lung Compliance; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011013:Pneumonectomy; D011030:Pneumothorax / Q000517:prevention & control; D011817:Rabbits; D011859:Radiography; D000267:Tissue Adhesions; D014014:Tissue Adhesives; D014945:Wound Healing
D001672:Biocompatible Materials; D014014:Tissue Adhesives; D003094:Collagen