Dietary fish oil sensitizes A549 lung xenografts to doxorubicin chemotherapy.
A549 xenografts were allowed to grow in nude mice to about 5 mm in diameter, then diets were changed to modified AIN-76 diets containing 19% wt./wt. fish oil (FO) or 20% wt./wt. corn oil (CO). Ten days later dietary ferric citrate (0.3% wt./dry wt.) was added and doxoribicin (DOX) treatment (3.6 mg/kg i.v. each of the 5 days for 18 days) commenced. Treatment with DOX halted the growth of tumors in the CO fed mice. However, in those mice, which consumed FO or FO with ferric citrate, treatment with DOX caused significant tumor regression.
Hardman
W E
WE
Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. hardman@uthscsa.edu
Moyer
M P
MP
Cameron
I L
IL
D000704:Analysis of Variance; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003314:Corn Oil / Q000008:administration & dosage / Q000494:pharmacology; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000494:pharmacology; D004317:Doxorubicin / Q000627:therapeutic use*; D004357:Drug Synergism; D005290:Ferric Compounds / Q000494:pharmacology; D005395:Fish Oils / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008175:Lung Neoplasms / Q000178:diet therapy / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012074:Remission Induction; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004042:Dietary Fats, Unsaturated; D005290:Ferric Compounds; D005395:Fish Oils; C025314:ferric citrate; D003314:Corn Oil; D004317:Doxorubicin