title: Prompt and durable engraftment in two older adult patients with high risk chronic myelogenous leukemia (CML) using ex vivo expanded and unmanipulated unrelated umbilical cord blood.
abstract: Delayed engraftment, graft failure, and adverse transplant-related events have been observed in unrelated umbilical cord blood (UCB) recipients, particularly in those receiving a low leukocyte cell dose and in CML patients. We report the outcomes of two older adult patients with high risk CML who received a low leukocyte cell dose of unmanipulated UCB cells supplemented with ex vivo expanded (AastromReplicell System) UCB cells. Each engrafted promptly and neither patient experienced GVHD or life-threatening infection. Both remain engrafted with cells exclusively of donor origin and are in cytogenetic remission at 19 and 8 months follow-up. Ex vivo expanded UCB cells appear to facilitate hematopoietic recovery and therefore may increase the number of CML patients eligible for unrelated UCB transplant.
authors.affiliation: Hackensack University Medical Center, Hackensack, NJ, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Pecora
authors.forename: P
authors.initials: P
authors.lastname: Stiff
authors.forename: A
authors.initials: A
authors.lastname: Jennis
authors.forename: S
authors.initials: S
authors.lastname: Goldberg
authors.forename: R
authors.initials: R
authors.lastname: Rosenbluth
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: K L
authors.initials: KL
authors.lastname: Goltry
authors.forename: J
authors.initials: J
authors.lastname: Douville
authors.forename: R D
authors.initials: RD
authors.lastname: Armstrong
authors.forename: A K
authors.initials: AK
authors.lastname: Smith
authors.forename: R A
authors.initials: RA
authors.lastname: Preti
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002066:Busulfan / Q000627:therapeutic use; D015925:Cryopreservation; D005260:Female; D005312:Fetal Blood / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000628:therapy*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D014470:Umbilical Cord
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D002066:Busulfan