[Development of lymphocytes].
Many subtypes in malignant lymphoma, especially those of B-cell lineage, have been established by linking morphologically each of them to one of the normal lymphoid development stages. Recent researches justified some of those entities in terms of clinical aspects and biological natures. Moreover, new techniques and findings in immunology settled many problems in the disease which had been unsolved by conventional ones. Single cell analysis on somatic hypermutation, for instance, shed light on the nature of Hodgkin's disease. A good knowledge of lymphocyte development makes it easier to understand malignant lymphoma, and is very important to hematologists and hematopathologists dealing with the disease. Development of lymphoid tissue and recent advances in this field will be briefly reviewed.
Takeuchi
K
K
Department of Pathology, Faculty of Medicine, University of Tokyo.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000502:physiology; D008223:Lymphoma / Q000473:pathology; D008565:Membrane Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D051757:PAX5 Transcription Factor; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; D051880:Receptors, Notch; D014157:Transcription Factors