[The current status and future applications of gene therapy and immunogene therapy for malignant lymphoma].
The present therapy for malignant lymphoma including stem cell transplantation, has been greatly developed. However, treatments still remain ineffective for many patients. Gene therapy is providing new strategies for the treatments of malignant lymphoma. There are three major approaches; 1) killing the tumor cell itself by introducing anti-sense genes against oncogene, tumor suppressor genes or drug-sensitive genes. 2) modifying the immune response by introducing genes that will trigger anti-tumor response or tumor specific genes to antigen presenting cell. 3) decreasing the sensitivity of hemopoietic cells by introducing drug resistance genes. We describe here the current and future applications of gene therapy for malignant lymphoma.
Abe
A
A
First Department of Internal Medicine, Nagoya University School of Medicine.
Emi
N
N
D000888:Antibodies, Anti-Idiotypic / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007376:Interleukin-2 / Q000235:genetics; D008223:Lymphoma / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D019253:Proto-Oncogene Proteins c-bcl-2
D000888:Antibodies, Anti-Idiotypic; D000951:Antigens, Neoplasm; D007376:Interleukin-2; D016376:Oligonucleotides, Antisense; D019253:Proto-Oncogene Proteins c-bcl-2