A phytochemical investigation of Alchornea latifolia.
A phytochemical investigation of the chloroform leaf extract of Alchornea latifolia has been undertaken. Along with the triterpenoids taraxerone, friedelin, epifriedelinol, and taraxerol, the plant also contains seco-3,4-friedelin (dihydroputranjivic acid) (1) and seco-3,4-taraxerone (2). These A-ring-opened triterpenoids show in vitro cytotoxic activity against Hep-G2 and A-431 human cancer cell lines and are potent inhibitors of topoisomerase II.
Setzer
W N
WN
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA. wsetzer@matsci.uah.edu
Shen
X
X
Bates
R B
RB
Burns
J R
JR
McClure
K J
KJ
Zhang
P
P
Moriarity
D M
DM
Lawton
R O
RO
D019665:Euphorbiaceae; D006801:Humans; D016488:Medicine, African Traditional; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves; D010946:Plants, Medicinal; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000094042:Lupanes
D009828:Oleanolic Acid; D010936:Plant Extracts; D014315:Triterpenes; C060796:friedelin; D000094042:Lupanes; C009379:taraxerone