Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice.
The organotin compounds dibutyltin (DBTC) and diphenyltin dichlorides (DPTC) were tested for trypanocidal activity on a Trypanosoma brucei-infected mice model. At a dose of 10 mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infected mice. Subinoculation of some healthy mice with the homogenates of liver, spleen, kidney, cerebrospinal fluid and blood from the mice considered cured, showed a few cases of relapse. The LD50 of DBTC and DPTC are 90 mg/kg and 75 mg/kg respectively.
Shuaibu
M N
MN
Institute of Tropical Medicine, Nagasaki University, Japan.
Ameh
D A
DA
Bonire
J J
JJ
Adaudi
A O
AO
Ibrahim
S
S
Nok
A J
AJ
D000818:Animals; D051379:Mice; D008807:Mice, Inbred BALB C; D009947:Organotin Compounds / Q000627:therapeutic use*; D018512:Parasitemia / Q000188:drug therapy; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014353:Trypanosomiasis, African / Q000188:drug therapy*
D009947:Organotin Compounds; C056189:di-n-butyltin; C086664:diphenyltin chloride; C020735:dibutyldichlorotin