title: Studies on controlled release dimenhydrinate from matrix tablet formulations.
abstract: In this study, controlled release dosage forms of dimenhydrinate were prepared with different polymers as MC, HEC, Carbopol 934, Eudragit RLPM and Eudragit NE 30 D at different concentrations (2.5-10%). Direct compression (DC) and wet granulation (WG) techniques were used to prepare the tablets. Magnesium stearate was the lubricant while starch gel was the binder. For the quality control of tablets prepared according to 11 different formulations, weight deviation, hardness, friability, diameter-height ratio, content uniformity of the active substance and in vitro dissolution techniques were performed. Dissolution rate of these tablets was controlled by USP XXII dissolution method and the profile of each tablet was plotted and only for F 5 was evaluated kinetically.
authors.affiliation: Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskişehir, Turkey. lgenc@andolu.edu.tr
authors.forename: L
authors.initials: L
authors.lastname: Genç
authors.forename: H
authors.initials: H
authors.lastname: Bilaç
authors.forename: E
authors.initials: E
authors.lastname: Güler
mesh_terms: D002626:Chemistry, Pharmaceutical; D004111:Dimenhydrinate / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D006634:Histamine H1 Antagonists / Q000008:administration & dosage*; D012995:Solubility; D013607:Tablets
chemical_list: D006634:Histamine H1 Antagonists; D013607:Tablets; D004111:Dimenhydrinate