title: Oral manifestations of pediatric vertical HIV infection.
abstract: To assess the prevalence and prognostic significance of the history of oral manifestations in children with human immunodeficiency virus infection (HIV), a cohort study of 73 children with vertical HIV infection was conducted. The study subjects were examined every 6 months for oral manifestations. The period prevalence of oral manifestations ranged from a low of 1% for submandibular enlargement and 3% for hairy leukoplakia to a high of 36% for xerostomia and 51% for cervical lymphadenopathy. The occurrence of oral manifestations did not change significantly over time from 1995 to 1998. Finally, the odds of occurrence of cervical lymphadenopathy, xerostomia, and oral candidiasis were greater among children in whom these manifestations had been diagnosed in the preceding 6-18 months than in children without prior diagnosis. Oral manifestations are significant clinical outcomes in pediatric vertical HIV infection, particularly for children diagnosed previously with an oral manifestation.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA. kozinetz@bcm.tmc.edu
authors.forename: C A
authors.initials: CA
authors.lastname: Kozinetz
authors.forename: A B
authors.initials: AB
authors.lastname: Carter
authors.forename: C
authors.initials: C
authors.lastname: Simon
authors.forename: M J
authors.initials: MJ
authors.lastname: Hicks
authors.forename: S N
authors.initials: SN
authors.lastname: Rossmann
authors.forename: C M
authors.initials: CM
authors.lastname: Flaitz
authors.forename: S G
authors.initials: SG
authors.lastname: Cron
authors.forename: M W
authors.initials: MW
authors.lastname: Kline
mesh_terms: D002180:Candidiasis, Oral / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008137:Longitudinal Studies; D008206:Lymphatic Diseases / Q000453:epidemiology; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D011379:Prognosis; D013781:Texas / Q000453:epidemiology; D014987:Xerostomia / Q000453:epidemiology