title: Severe heart valve calcification in a young patient with Werner syndrome.
abstract: Werner syndrome is a rare autosomal recessive disorder characterized by the appearance of premature aging. We report on severe aortic and mitral valve calcification in an 18-year-old girl, necessitating double valve replacement. These special cardiovascular findings are discussed with regard to diagnosis and treatment.
authors.affiliation: Clinic for Cardiothoracic and Vascular Surgery, Heart and Diabetes Centre Mecklenburg-Vorpommern, Klinikum Karlsburg, Germany. Grubitzsch@t-online.de
authors.forename: H
authors.initials: H
authors.lastname: Grubitzsch
authors.forename: S
authors.initials: S
authors.lastname: Beholz
authors.forename: H G
authors.initials: HG
authors.lastname: Wollert
authors.forename: L
authors.initials: L
authors.lastname: Eckel
mesh_terms: D000293:Adolescent; D001021:Aortic Valve / Q000473:pathology* / Q000601:surgery; D002114:Calcinosis / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008943:Mitral Valve / Q000473:pathology* / Q000601:surgery; D014898:Werner Syndrome / Q000150:complications / Q000473:pathology* / Q000601:surgery