Cerebriform nodular amelanotic metastases of malignant melanoma: a challenge in differential diagnosis of a rare variant.
High variability of the clinical appearance of malignant melanoma (MM) and its metastases render the differential diagnosis of solid amelanotic tumours difficult. We report a 71-year-old woman with several unusual cutaneous tumours of cerebriform morphology, suggesting skin metastases from occult internal cancer. Histopathological findings and thorough investigations, however, revealed a late-stage metastatic MM. We discuss the differential diagnosis of skin metastases of various origin and underline the difficulties for early detection of MM.
Assmann
A
A
Department of Dermatology, University Medical Centre Benjamin Franklin, The Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany.
Farthmann
B
B
Burkhardt
O
O
Dippel
E
E
Orfanos
C E
CE
Blume-Peytavi
U
U
D000368:Aged; D014408:Biomarkers, Tumor; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D018328:Melanoma, Amelanotic / Q000175:diagnosis / Q000556:secondary* / Q000648:ultrastructure; D009382:Neoplasms, Unknown Primary; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor