title: The number of CD34+ cells mobilized into the peripheral blood can predict the quality of subsequent collections.
abstract: PBPC were mobilized using a variety of chemotherapy regimens plus G-CSF in a group of 126 consecutive patients. Data are presented that show a close correlation between the number of CD34+ cells mobilized into the peripheral blood (PB) and the number of CD34+ cells subsequently collected by leukapheresis (R = 0.904). On the basis of this correlation, a regression formula was calculated that could give an estimate of the total number of CD34+ cells likely to be collected by leukapheresis from a given number of CD34+ cells per microliter PB. An easy-to-read table has been compiled to show how this type of analysis can be applied to predict the likely dose of CD34+ cells that will be obtained by leukapheresis over a wide range of patient weights.
authors.affiliation: Department of Haematology, Glasgow Royal Infirmary University NHS Trust, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Alcorn
authors.forename: E
authors.initials: E
authors.lastname: Farrell
authors.forename: J
authors.initials: J
authors.lastname: Barr
authors.forename: C
authors.initials: C
authors.lastname: Pearson
authors.forename: R
authors.initials: R
authors.lastname: Green
authors.forename: T
authors.initials: T
authors.lastname: Holyoake
mesh_terms: D018952:Antigens, CD34 / Q000097:blood*; D001835:Body Weight; D002985:Clinical Protocols; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007937:Leukapheresis / Q000592:standards*; D011786:Quality Control; D012189:Retrospective Studies
chemical_list: D018952:Antigens, CD34