Cycloaromatization and DNA cleavage of novel non-conjugated aromatic enetetrayne systems.
The novel, non-conjugated aromatic enetetrayne (2) underwent thermal cycloaromatization reaction to give polyphenylene derivative 6, forming a methyl cation as an active intermediate, and showed DNA-cleaving activity.
Ueda
I
I
Institute of Scientific and Industrial Research, Osaka University, Japan. ueda@sanken.osaka-u.ac.jp
Miyawaki
K
K
Sugane
T
T
Sakurai
Y
Y
Wada
Y
Y
Futai
M
M
D000480:Alkynes / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D004249:DNA Damage / Q000187:drug effects*; D004278:DNA, Superhelical / Q000187:drug effects; D006358:Hot Temperature; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000480:Alkynes; D004278:DNA, Superhelical; D006841:Hydrocarbons, Aromatic