title: Recurrent anomalies of 6q25 in chondromyxoid fibroma.
abstract: Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] has been proposed as a specific genetic marker for chondromyxoid fibroma. In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoid fibroma cases showed clonal abnormalities of chromosome 6 but at a breakpoint on the long arm (q25) distal to that described in the pericentric inversion. These findings suggest that several distinct breakpoints on chromosome 6 are nonrandomly involved in chondromyxoid fibroma.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.
authors.forename: A
authors.initials: A
authors.lastname: Safar
authors.forename: M
authors.initials: M
authors.lastname: Nelson
authors.forename: J R
authors.initials: JR
authors.lastname: Neff
authors.forename: G E
authors.initials: GE
authors.lastname: Maale
authors.forename: J
authors.initials: J
authors.lastname: Bayani
authors.forename: J
authors.initials: J
authors.lastname: Squire
authors.forename: J A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D002804:Chondroblastoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D011859:Radiography; D012008:Recurrence; D013977:Tibia / Q000000981:diagnostic imaging; D014178:Translocation, Genetic