Beta,gamma-methylene ATP but not alpha,beta-methylene ATP mimics the inhibitory effect of ATP on ventricular automaticity.
The effects of alpha,beta- and beta,gamma-methylene ATP on ventricular automaticity induced by local injury in the right ventricle of rats pretreated with reserpine, were investigated and compared with the effects of ATP and adenosine. Beta,gamma-methylene ATP but not alpha,beta-methylene ATP mimicked the inhibitory effect of both ATP and adenosine on the spontaneous automaticity In low concentrations, adenosine was more effective than ATP. Alpha,beta-methylene ATP caused little or no effect on ventricular automaticity. The results suggest that the effect of ATP might depend on its hydrolysis into AMP/adenosine.
Hernández
J
J
Department of Pharmacology, Faculty of Medicine, Espinardo Murcia, Spain. jehernca@fcu.um.es
Laorden
M L
ML
Ruiz
F
F
Ribeiro
J A
JA
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006352:Heart Ventricles / Q000187:drug effects* / Q000293:injuries / Q000503:physiopathology; D008297:Male; D018716:Molecular Mimicry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology
C005147:5'-adenylyl (beta,gamma-methylene)diphosphonate; D012110:Reserpine; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate