title: Biomimetic modeling of copper oxidase reactivity.
abstract: Bioinspired copper-model-complexes that react with O(2) provide an opportunity to probe biological reactivity at a small-molecule level of detail. Biological structural information combined with appropriate ligand design has proven sufficient to create Cu:O(2) complexes capable of external substrate oxidation. Most notable developments during the review period are the bioinspired catalysts capable of aerobic alcohol-oxidation. The extension of this oxidative reactivity to other important organic transformations beyond the scope of the inspiring system completes a modeling paradigm.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
authors.forename: V
authors.initials: V
authors.lastname: Mahadevan
authors.forename: R K
authors.initials: RK
authors.lastname: Gebbink
authors.forename: T D
authors.initials: TD
authors.lastname: Stack
mesh_terms: D002384:Catalysis; D003300:Copper; D004578:Electron Spin Resonance Spectroscopy; D008956:Models, Chemical; D010088:Oxidoreductases / Q000737:chemistry* / Q000378:metabolism*; D010100:Oxygen
chemical_list: D003300:Copper; D010088:Oxidoreductases; C024748:copper oxidase; D010100:Oxygen