Identification of SopE2, a Salmonella secreted protein which is highly homologous to SopE and involved in bacterial invasion of epithelial cells.
Type III secreted Sop protein effectors are delivered into target eukaryotic cells and elicit cellular responses underlying Salmonella pathogenicity. In this work, we have identified another secreted protein, SopE2, and showed that SopE2 is an important invasion-associated effector. SopE2 is encoded by the sopE2 gene which is present and conserved in pathogenic strains of Salmonella. SopE2 is highly homologous to SopE, a protein encoded by a gene within a temperate bacteriophage and present in only some pathogenic strains.
Bakshi
C S
CS
Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom.
Singh
V P
VP
Wood
M W
MW
Jones
P W
PW
Wallis
T S
TS
Galyov
E E
EE
D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000378:metabolism*; D017124:Conserved Sequence; D004847:Epithelial Cells / Q000382:microbiology*; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D019779:Salmonella enterica / Q000235:genetics / Q000472:pathogenicity*; D017386:Sequence Homology, Amino Acid
D001426:Bacterial Proteins; C103987:SopE protein, Salmonella