title: Decatromicins A and B, new antibiotics produced by Actinomadura sp. MK73-NF4. I. Taxonomy, isolation, physico-chemical properties and biological activities.
abstract: New antibiotics designated decatromicins A and B were isolated from the culture broth of Actinomadura sp. MK73-NF4. They were purified by butyl acetate extraction, silica gel column chromatography, silica gel TLC and Sephadex LH-20 column chromatography. Decatromicins A and B inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Momose
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: N
authors.initials: N
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Momose
authors.forename: S
authors.initials: S
authors.lastname: Kunimoto
authors.forename: M
authors.initials: M
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C405842:decatromicin A; C405843:decatromicin B