Cell polarity: Nailing Crumbs to the scaffold.
Recent studies suggest that the cytoplasmic tail of the Crumbs protein establishes membrane territories in polarised epithelial cells by stabilising a PDZ-domain protein complex. The isolation of a human Crumbs homologue required for normal vision revives questions about the role of Crumbs in cell-cell interactions.
Rashbass
P
P
Developmental Genetics Programme, Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK.
Skaer
H
H
D017398:Alternative Splicing; D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D029721:Drosophila Proteins; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology
D029721:Drosophila Proteins; D008565:Membrane Proteins; D020033:Protein Isoforms; C064360:crb protein, Drosophila