Impact of a plastid-bearing endocytobiont on apicomplexan genomes.
Both the chromosomal and extrachromosomal components of the apicomplexan genome have been supplemented by genes from a plastid-bearing endocytobiont: probably an algal cell. The sequence of the apicomplexan plastid's vestigial genome indicates that a large number (>100) of genes of endocytobiotic origin must have transferred laterally to the host cell nucleus where they control maintenance of the plastid organelle and supply its functional components by means of post-translational protein trafficking. Should the nuclear genes prove to be less divergent phylogenetically than those left on the plastid genome, they might give better clues than we have at present to the origin of the plastid-bearing endocytobiont. Most of these nuclear genes still await discovery, but the on-going genome sequencing project will reveal the function of the organelle, as well as many "housekeeping" processes of interest on a wider front. The plastid's own protein synthetic machinery, being cyanobacterial in origin, offers conventional targets for antibiotic intervention, and this is discussed here using a structural model of elongation factor Tu. Uncovering the vital function(s) of the plastid organelle will provide new drug targets.
Sato
S
S
National Institute for Medical Research, Mill Hill, London, UK.
Tews
I
I
Wilson
R J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D016782:Apicomplexa / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010444:Peptide Elongation Factor Tu / Q000235:genetics; D010802:Phylogeny; D018087:Plastids / Q000235:genetics*; D000623:Porphobilinogen Synthase / Q000235:genetics
D010444:Peptide Elongation Factor Tu; D000623:Porphobilinogen Synthase