Plasma apolipoprotein B levels predict platelet-dependent thrombosis in patients with coronary artery disease.
Elevated plasma apolipoprotein B is a known risk factor for atherosclerotic coronary artery disease (CAD), however its relationship to arterial thrombosis is unexplored. We prospectively assessed apolipoprotein B and platelet-dependent thrombosis (PDT) in 42 CAD patients (37 men, 5 women, mean age 68 +/- 9 years), by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 min using an ex vivo perfusion (Badimon) chamber. PDT was significantly correlated with apolipoprotein B (r = 0.41, p = 0.009), intracellular magnesium levels (r = -0.46, p = 0.003) fasting blood glucose (r = 0.47, p = 0.002), and total cholesterol (r = 0.43, p = 0.006). PDT did not correlate with serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I or fibrinogen levels. These findings suggest that the positive relationship of elevated apolipoprotein B to CAD may be, in part, related to its prothrombotic effects.
Shechter
M
M
Preventive & Rehabilitative Cardiac Center and Atherosclerosis Research Center, Cedars-Sinai Burns and Allen Research Institute, Department of Medicine, Division of Cardiology, Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angele, CA, USA.
Bairey Merz
C N
CN
Paul-Labrador
M J
MJ
Shah
P K
PK
Kaul
S
S
D000368:Aged; D000369:Aged, 80 and over; D001055:Apolipoproteins B / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001792:Blood Platelets / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008274:Magnesium / Q000097:blood / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010976:Platelet Count; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood* / Q000175:diagnosis / Q000473:pathology
D001055:Apolipoproteins B; D015415:Biomarkers; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D005340:Fibrinogen; D002784:Cholesterol; D008274:Magnesium