title: A canine model of multiple portosystemic shunting.
abstract: The objective of this study was to develop and describe an experimental canine model of multiple acquired portosystemic shunts (PSS) similar in nature to spontaneously occurring PSS. Sixteen dogs were used and were divided into a control (n = 6) and a diseased group (n = 10). Dogs of the diseased group were administered dimethylnitrosamine (2 mg/kg of body weight, po) twice weekly, and clinicopathologic, ultrasonographic, and hepatic scintigraphic findings were recorded during the development of hepatic disease and PSS. Surgery was then performed to permit visual verification of multiple shunts, catheter placement for portography examination, and biopsy of the liver. All diseased dogs developed severe hepatic disease and multiple PSS as documented visually at surgery and on portography. Based on this study, dimethylnitrosamine-induced portosystemic shunting appears to be an appropriate model for spontaneously occurring multiple PSS secondary to portal hypertension.
authors.affiliation: Department of Small Animal Medicine and Surgery, Texas Veterinary Medical Center, Texas A&M University, College Station 77843-4474, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Howe
authors.forename: H W
authors.initials: HW
authors.lastname: Boothe
authors.forename: M W
authors.initials: MW
authors.lastname: Miller
authors.forename: D M
authors.initials: DM
authors.lastname: Boothe
mesh_terms: D000818:Animals; D004128:Dimethylnitrosamine / Q000633:toxicity; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008106:Liver Cirrhosis, Experimental / Q000000981:diagnostic imaging / Q000601:surgery*; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D011170:Portasystemic Shunt, Surgical; D011877:Radionuclide Imaging; D014463:Ultrasonography
chemical_list: D004128:Dimethylnitrosamine