title: Expression of CRYP-alpha, LAR, PTP-delta, and PTP-rho in the developing Xenopus visual system.
abstract: Receptor protein tyrosine phosphatases (RPTPs), are involved in axon outgrowth and guidance not only in the Drosophila visual system (Garrity et al., 1999. Neuron 22, 707-717) but also in the developing vertebrate retina (Ledig et al., 1999a. J. Cell Biol. 147, 375-388). We have cloned a variety of Xenopus RPTPs, including four RPTPs expressed in the developing visual system (LAR, PTP-delta, CRYP-alpha and PTP-rho). These four RPTPs are transcribed in the developing optic vesicle during differentiation and in overlapping but distinct patterns in the developing retina during retinal layer formation. LAR, PTP-delta, and CRYP-alpha are also expressed in retinal ganglion cells during axonogenesis and during axon guidance from the retina to the optic tectum.
authors.affiliation: Department of Anatomy, University of Cambridge, Downing Street, Cambridge, UK.
authors.forename: K G
authors.initials: KG
authors.lastname: Johnson
authors.forename: C E
authors.initials: CE
authors.lastname: Holt
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D004625:Embryo, Nonmammalian; D018507:Gene Expression Regulation, Developmental; D008969:Molecular Sequence Data; D017027:Protein Tyrosine Phosphatases / Q000235:genetics* / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D054557:Receptor-Like Protein Tyrosine Phosphatases; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2; D012160:Retina / Q000196:embryology / Q000502:physiology; D014785:Vision, Ocular / Q000502:physiology*; D014981:Xenopus / Q000196:embryology / Q000235:genetics*; D029867:Xenopus Proteins
chemical_list: D029867:Xenopus Proteins; D020794:Receptor Protein-Tyrosine Kinases; C094525:CRYPalpha protein, Xenopus; D017027:Protein Tyrosine Phosphatases; C490394:Ptprd protein, Xenopus; D054557:Receptor-Like Protein Tyrosine Phosphatases; D054623:Receptor-Like Protein Tyrosine Phosphatases, Class 2