Linkage mapping of the Fos cellular oncogene (Fos) to rat chromosome 6 and its possible role in the regulation of compensatory renal growth.
Using the analysis of HXB/BXH recombinant inbred (RI) strains, we have recently detected a suggestive association between the D6Mit9 marker and a compensatory growth of the remnant kidney after unilateral nephrectomy (P = 6 x 10(-)4). Based on conserved synteny between mice, rats, and humans, the putative quantitative trait locus (QTL) might map to a region with several positional candidate genes: for instance, the Fos oncogene was implicated as a possible candidate gene for compensatory renal growth (CRG). In the current study, we mapped the Fos gene in RI strains 27 cM apart from the position where the putative CRG regulatory QTL was detected. Despite relatively wide confidence intervals for mapping QTLs with modest effects in a small population of RI strains, this finding probably excludes the Fos as a positional candidate for CRG.
Pravenec
M
M
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Zídek
V
V
Simáková
M
M
Vorlícek
J
J
Kren
V
V
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D017931:DNA Primers / Q000235:genetics; D016762:Genes, fos; D008040:Genetic Linkage; D006801:Humans; D007668:Kidney / Q000254:growth & development*; D008297:Male; D051379:Mice; D009392:Nephrectomy; D019655:Quantitative Trait, Heritable; D051381:Rats; D011914:Rats, Inbred BN; D011918:Rats, Inbred SHR; D011995:Recombination, Genetic
D017931:DNA Primers