Birth of a foal after oocyte transfer to a nonovulating, hormone-treated recipient mare.
A nonovulating, hormone-treated mare was used successfully as an oocyte recipient. The mare's ovarian activity was suppressed using progesterone and estrogen treatment. This treatment was stopped, then estrogen was administered for 3 d prior to the transfer. An oocyte was recovered from the follicle of a donor mare and was transferred via flank laparotomy into the recipient's oviduct. The recipient mare was inseminated 7 h before transfer. The recipient was treated with intramuscular progesterone from the day after transfer until 47 d after transfer, and then with oral altrenogest until 150 d gestation. A normal colt was born at 321 d gestation, and was shown by DNA analysis to be the progeny of the donor mare. This is the first report of fertilization and embryo development to term after transfer of oocytes to a nonovulating mare, and, to our knowledge, the first of its kind in any domestic species.
Hinrichs
K
K
Section of Large Animal Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA.
Provost
P J
PJ
Torello
E M
EM
D000818:Animals; D000858:Anovulation / Q000139:chemically induced; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D015237:Dinoprost / Q000008:administration & dosage; D005260:Female; D005865:Gestational Age; D006736:Horses; D007315:Insemination, Artificial / Q000662:veterinary; D018587:Oocyte Donation / Q000662:veterinary*; D009865:Oocytes / Q000637:transplantation; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage; D014204:Trenbolone Acetate / Q000008:administration & dosage / Q000031:analogs & derivatives; D016216:Ultrasonography, Prenatal
D006063:Chorionic Gonadotropin; C023445:altrenogest; D011374:Progesterone; D015237:Dinoprost; D014204:Trenbolone Acetate