title: The question of DNA repair in hyperthermophilic archaea.
abstract: Hyperthermophilic archaea grow at temperatures that destabilize the primary structure of DNA and in evolutionary terms they are highly divergent from other well studied microorganisms. These prokaryotes should therefore require DNA damage repair to be unusually effective, and could employ novel mechanisms for this repair. Recent genome sequence analyses and biochemical and genetic assays suggest a distribution of DNA repair strategies that raises intriguing questions for future study.
authors.affiliation: Dept of Biological Sciences, University of Cincinnati, PO Box 210006, Cincinnati OH 45221-0006, USA. grogandw@email.uc.edu
authors.forename: D W
authors.initials: DW
authors.lastname: Grogan
mesh_terms: D001105:Archaea / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics; D004260:DNA Repair / Q000235:genetics*; D019641:DNA, Archaeal / Q000235:genetics; D020745:Genome, Archaeal; D006358:Hot Temperature
chemical_list: D019641:DNA, Archaeal