title: Early childhood attention deficit hyperactivity disorder predicts poorer response to acute lithium therapy in adolescent mania.
abstract: We compared the response to acute lithium therapy in 30 adolescents, 13-17 years of age, with mania and a prior history of early childhood attention deficit hyperactivity disorder (ADHD) to a sex- and age-matched control group of adolescent manics without premorbid psychiatric illness. Response to treatment was assessed daily over the course of 28 days using measures of global clinical improvement and severity ratings on the Bech-Rafaelsen Mania Scale (BRMS). BRMS scores decreased by a mean of 24.3 in the subgroup without prior ADHD compared to 16.7 in patients with ADHD (P = 0.0005). The average percent drop in BRMS scores over the study period in these two subgroups was 80.6% and 57.7%, respectively (P = 0.0005). Time to onset of sustained global clinical improvement was also assessed using Kaplan-Meier survival methods and possible covariates of time to improvement were tested in a Cox proportional hazards model. Median time to onset of sustained improvement was lengthened significantly in patients with early ADHD (23 days) compared to those without it (17 days; log rank chi2 = 7.2, P = 0.007). The results suggest that early childhood ADHD defines an important source of heterogeneity in bipolar illness with developmental, clinical, and neuropharmacogenetic implications.
authors.affiliation: Neuropsychiatric Institute and Hospital, School of Medicine, University of California at Los Angeles, 90024-1759, USA. mstrober@mednet.ucla.edu
authors.forename: M
authors.initials: M
authors.lastname: Strober
authors.forename: M
authors.initials: M
authors.lastname: DeAntonio
authors.forename: S
authors.initials: S
authors.lastname: Schmidt-Lackner
authors.forename: R
authors.initials: R
authors.lastname: Freeman
authors.forename: C
authors.initials: C
authors.lastname: Lampert
authors.forename: J
authors.initials: J
authors.lastname: Diamond
mesh_terms: D000293:Adolescent; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D018692:Antimanic Agents; D016651:Lithium Carbonate