title: Developmental regulation of membrane type-5 matrix metalloproteinase (MT5-MMP) expression in the rat nervous system.
abstract: An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domain that restricts protease activity at the cell surface. Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development.
authors.affiliation: Department of Anatomy, University of Vermont College of Medicine, Given C454, Burlington, VT, USA. djaworsk@zoo.uvm.edu
authors.forename: D M
authors.initials: DM
authors.lastname: Jaworski
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D018076:DNA, Complementary / Q000235:genetics; D004790:Enzyme Induction; D005109:Extracellular Matrix / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D005865:Gestational Age; D017403:In Situ Hybridization; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000096:biosynthesis* / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013116:Spinal Cord / Q000196:embryology / Q000201:enzymology
chemical_list: D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases; C492242:Mmp24 protein, rat