Synthesis of cyclic oligopeptides containing an Arg-Gly-Asp (RGD) sequence.
The synthesis of cyclic RGD peptides with 8-10 residues cyclized by an amide bond and the relationship between their structure and activity (i.e. circular dichroism spectrum and inhibition of platelet aggregation) are reported. The linear peptides were synthesized by the solution method and their cyclization was performed in high dilution using DPPA.
Sofuku
S
S
Department of Chemistry, Rikkyo University, Tokyo, Japan.
Hoshida
A
A
Shimada
T
T
Takada
Y
Y
Takakuwa
T
T
D001386:Azides; D003500:Cyclization; D006801:Humans; D066298:In Vitro Techniques; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D001386:Azides; D009842:Oligopeptides; D010456:Peptides, Cyclic; D010975:Platelet Aggregation Inhibitors; C047981:arginyl-glycyl-aspartic acid; C007523:diphenylphosphorazidate