title: Primary immunodeficiencies of horses.
abstract: Primary immunodeficiency disorders are genetically determined failures of immune defense that increase susceptibility to infectious agents. This article reviews the salient features of equine primary immunodeficiency disorders, summarizes the molecular mechanisms of each disorder, and updates information that facilitates diagnosis and management of affected horses. The central theme is to encourage clinicians to ask, "I wonder if this horse has an underlying primary immunodeficiency disorder?" when caring for horses suffering from chronic and recurring infections and responding poorly to standard therapy.
authors.affiliation: Department of Microbiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Perryman
mesh_terms: D000361:Agammaglobulinemia / Q000662:veterinary; D000818:Animals; D006734:Horse Diseases / Q000276:immunology*; D006736:Horses; D007075:Immunoglobulin M / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000662:veterinary*; D016511:Severe Combined Immunodeficiency / Q000276:immunology / Q000662:veterinary
chemical_list: D007075:Immunoglobulin M