title: Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides.
abstract: Altritol nucleic acids (ANAs) are RNA analogues with a phosphorylated D-altritol backbone. The nucleobase is attached at the 2-(S)-position of the carbohydrate moiety. We report that ANA oligomers are superior to the corresponding DNA, RNA, and HNA (hexitol nucleic acid) in supporting efficient nonenzymatic template-directed synthesis of complementary RNAs from nucleoside-5'-phosphoro-2-methyl imidazolides. Activated ANA and HNA monomers do not oligomerize efficiently on DNA, RNA, HNA, or ANA templates.
authors.affiliation: The Salk Institute for Biological Studies, San Diego, California 92186, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Kozlov
authors.forename: M
authors.initials: M
authors.lastname: Zielinski
authors.forename: B
authors.initials: B
authors.lastname: Allart
authors.forename: L
authors.initials: L
authors.lastname: Kerremans
authors.forename: A
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: R
authors.initials: R
authors.lastname: Busson
authors.forename: P
authors.initials: P
authors.lastname: Herdewijn
authors.forename: L E
authors.initials: LE
authors.lastname: Orgel
mesh_terms: D002621:Chemistry / Q000379:methods; D004247:DNA / Q000737:chemistry*; D006157:Guanosine Monophosphate / Q000031:analogs & derivatives / Q000737:chemistry; D009696:Nucleic Acids / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013402:Sugar Alcohols / Q000737:chemistry*; D013698:Templates, Genetic
chemical_list: D009696:Nucleic Acids; D009841:Oligonucleotides; D013402:Sugar Alcohols; C042890:altritol; D012313:RNA; C036896:guanosine 5'-phospho-2-methylimidazolide; D006157:Guanosine Monophosphate; D004247:DNA