title: Treatment of severe atopic dermatitis by topical immune modulation using dinitrochlorobenzene.
abstract: We present the results of a small uncontrolled pilot trial which suggest that contact sensitization to dinitrochlorobenzene and repeated weekly applications significantly improve the clinical status of severe atopic dermatitis in adults. Although no changes were noted in circulating levels of either lymphocyte subset populations or the serum cytokines assayed in this trial, our observations may be due to topical immune modulation by dinitrochlorobenzene. Larger controlled studies of dinitrochlorobenzene treatment in atopic dermatitis are warranted.
authors.affiliation: Department of Dermatology, The Honolulu Medical Group, Inc, Honolulu, USA. lmills@pixi.com
authors.forename: L B
authors.initials: LB
authors.lastname: Mills
authors.forename: L J
authors.initials: LJ
authors.lastname: Mordan
authors.forename: H L
authors.initials: HL
authors.lastname: Roth
authors.forename: E E
authors.initials: EE
authors.lastname: Winger
authors.forename: W L
authors.initials: WL
authors.lastname: Epstein
mesh_terms: D000287:Administration, Topical; D000328:Adult; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010865:Pilot Projects
chemical_list: D004137:Dinitrochlorobenzene