Serum cholesterol level, cigarette smoking, and vasomotor responses to L-arginine in narrowed epicardial coronary arteries.
We examined the impact of serum cholesterol and cigarette smoking on the coronary vasomotor effects of L-arginine in patients with atherosclerotic coronary artery disease. The dilation of proximal and distal segments in response to low-dose L-arginine was greater in patients with a serum cholesterol level < or =200 mg/dl than in patients with a level >200 mg/dl, whereas the response was the same in smokers and nonsmokers.
Tentolouris
C
C
Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece.
Tousoulis
D
D
Davies
G J
GJ
Stefanadis
C
C
Toutouzas
P
P
D001120:Arginine / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage; D011379:Prognosis; D012907:Smoking / Q000009:adverse effects*; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage
D015415:Biomarkers; D014665:Vasodilator Agents; D001120:Arginine; D002784:Cholesterol; D005996:Nitroglycerin