Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines.
A set of O-substituted aryl beta-D-glucopyranosides were prepared and found to have inhibitory activity on the growth of two carcinoma cell lines.
Hanessian
S
S
Department of Chemistry, Université de Montréal, CP 6128, Succursale Centre-ville, PQ, Canada. hanessia@ere.umontreal.ca
Saavedra
O M
OM
Xie
F
F
Amboldi
N
N
Battistini
C
C
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured; D018909:src Homology Domains / Q000187:drug effects*
D000970:Antineoplastic Agents; D005960:Glucosides; D008024:Ligands