title: Design and synthesis of functionalized glycomers as non-peptidic ligands for SH2 binding and as inhibitors of A-431 human epidermoid and HT-29 colon carcinoma cell lines.
abstract: A set of O-substituted aryl beta-D-glucopyranosides were prepared and found to have inhibitory activity on the growth of two carcinoma cell lines.
authors.affiliation: Department of Chemistry, Université de Montréal, CP 6128, Succursale Centre-ville, PQ, Canada. hanessia@ere.umontreal.ca
authors.forename: S
authors.initials: S
authors.lastname: Hanessian
authors.forename: O M
authors.initials: OM
authors.lastname: Saavedra
authors.forename: F
authors.initials: F
authors.lastname: Xie
authors.forename: N
authors.initials: N
authors.lastname: Amboldi
authors.forename: C
authors.initials: C
authors.lastname: Battistini
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology; D019073:HT29 Cells; D006801:Humans; D008024:Ligands; D008968:Molecular Conformation; D014407:Tumor Cells, Cultured; D018909:src Homology Domains / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents; D005960:Glucosides; D008024:Ligands