title: Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation.
abstract: A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-diphosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity.
authors.affiliation: Dipartimento Farmacochimico, Università degli Studi, Bari, Italy. altomare@farmchim.uniba.it
authors.forename: C
authors.initials: C
authors.lastname: Altomare
authors.forename: L
authors.initials: L
authors.lastname: Summo
authors.forename: S
authors.initials: S
authors.lastname: Cellamare
authors.forename: A V
authors.initials: AV
authors.lastname: Varlamov
authors.forename: L G
authors.initials: LG
authors.lastname: Voskressensky
authors.forename: T N
authors.initials: TN
authors.lastname: Borisova
authors.forename: A
authors.initials: A
authors.lastname: Carotti
mesh_terms: D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013988:Ticlopidine / Q000494:pharmacology
chemical_list: D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D011725:Pyridines; D011758:Pyrroles; D000244:Adenosine Diphosphate; D013988:Ticlopidine