Ready access to sialylated oligosaccharide donors.
[formula: see text] Numerous glycoconjugates contain the disaccharide Neu5Ac alpha (2-->3)DGalp. An efficient way to incorporate this disaccharide into synthetic glycoconjugates is to develop a disaccharide building block. This communication reports a chemoenzymatic route to such a building block which requires as few as four steps. Some examples using more chemical steps are also presented, which increase the flexibility. These disaccharide donors were used to prepare synthetic trisaccharides.
Mehta
S
S
National Research Council, Ottawa, Ontario, Canada.
Gilbert
M
M
Wakarchuk
W W
WW
Whitfield
D M
DM
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000737:chemistry*; D006001:Glycoconjugates / Q000737:chemistry; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D012794:Sialic Acids
D004187:Disaccharides; D006001:Glycoconjugates; D009844:Oligosaccharides; D012794:Sialic Acids