Monoamines and sleep: microdialysis findings in pons and amygdala.
This is the first microdialysis report comparing concentrations (pg/microliter) of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) derived from feline locus ceruleus complex (LC) and amygdala. NE and 5-HT declined progressively from waking to slow-wave-sleep (SWS) and then to rapid-eye-movement (REM) sleep. Concentrations of DA did not change at either collection site across the sleep-wake cycle. We conclude that release of NE and 5-HT release modulates physiologic components related to the sleep-wake cycle, but DA does not.
Shouse
M N
MN
Department of Veterans Affairs, Greater Los Angeles Health Care System, (151A3) Sepulveda, CA, USA. nshouse@ucla.edu
Staba
R J
RJ
Saquib
S F
SF
Farber
P R
PR
D000679:Amygdala / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000502:physiology; D002415:Cats; D004298:Dopamine / Q000378:metabolism*; D004569:Electroencephalography; D005260:Female; D008125:Locus Coeruleus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D017551:Microdialysis; D009638:Norepinephrine / Q000378:metabolism*; D011149:Pons / Q000502:physiology; D012701:Serotonin / Q000378:metabolism*; D012894:Sleep Stages / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology
D012701:Serotonin; D004298:Dopamine; D009638:Norepinephrine