Circulating plasma platinum more than 10 years after cisplatin treatment for testicular cancer.
We have shown in patients cured from metastatic testicular cancer that up to 20 years after administration of cisplatin-containing chemotherapy, circulating platinum is still detectable in plasma. This finding may influence the development of long-term, treatment-related side-effects.
Gietema
J A
JA
Meinardi
M T
MT
Messerschmidt
J
J
Gelevert
T
T
Alt
F
F
Uges
D R
DR
Sleijfer
D T
DT
D000293:Adolescent; D000328:Adult; D002945:Cisplatin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D010984:Platinum / Q000493:pharmacokinetics*; D013736:Testicular Neoplasms / Q000097:blood* / Q000188:drug therapy
D010984:Platinum; D002945:Cisplatin