Lubricant susceptibility of Cellactose and Avicel PH-200: a quantitative relationship.
The lubricant susceptibility of two direct compression excipients, Avicel PH-200 and Cellactose, was determined using a model mix with metamizol sodium (dipyrone) and designed experiments to obtain a quantitative relationship by multiple regression. As a result, a new constant called specific lubricant sensibility Ls is proposed for the comparison of lubricant susceptibility in other drug-excipient systems.
Estrada Flores
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L
Section of Pharmaceutical Technology, Facultad de Estudios Superiores Cuautitlan UNAM, México.
López Arellano
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R
Díaz Esquivel
J J
JJ
D002482:Cellulose / Q000031:analogs & derivatives*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D005079:Excipients / Q000737:chemistry*; D008153:Lubrication; D012044:Regression Analysis
D005079:Excipients; D002482:Cellulose