Reversed bowel segments for the treatment of short bowel syndrome: assessment of their minimal length in correlation with electromyographic pattern in the rat.
Reversal of a distal intestinal loop is a surgical therapy intended to cure rapid intestinal transit in short bowel syndrome. To be active, a reversed loop must present a retrograde propagation of electromyographic patterns and must not be so long as to cause total obstruction. The aim of the current study was to propose methods to calculate the minimal length of the intestinal reversed loop taking into consideration the two previous conditions. Intestinal electromyograms were recorded in 65 rats at short-term (4 days after surgery) and ten rats at long-term (50 days after surgery). Control rats demonstrated that the preprandial regular spiking activity (RSA) of the migrating myoelectrical complex (MMC) extended simultaneously a definite part of the intestine which corresponds to the minimal length to reverse. A similar result can be obtained from a trigonometric representation. Whatever the method, the minimal lengths allowing the recording of RSA decreased along the rat intestine from 6 cm (proximal jejunum) to 4 cm (distal ileum). The experiments demonstrated that shorter loops did not present the preprandial RSA. In conclusion, the minimal reversed length depends on intestinal electromyographic parameters and, thereby, on the intestinal level.
Chabert
J
J
Laboratoire de Physiologie et Pharmacologie Appliquées (et INSERM U45, Hôpital Herriot, Lyon), Université de Savoie, France.
Pellissier
S
S
Eribon
O
O
Roche
M
M
D000818:Animals; D004576:Electromyography; D005215:Fasting / Q000502:physiology; D005769:Gastrointestinal Motility / Q000502:physiology; D007082:Ileum / Q000502:physiology / Q000601:surgery; D007583:Jejunum / Q000502:physiology / Q000601:surgery; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012778:Short Bowel Syndrome / Q000503:physiopathology* / Q000601:surgery*; D013514:Surgical Procedures, Operative / Q000379:methods