Experimental hypertriglyceridaemia and hypercholesterolaemia in rats.
Lipid disorders and cardiovascular diseases have been related in many studies. We here studied the influence of acute ingestion of a long chain triglyceride (LCT) emulsion (rich in triglycerides) on plasma triglyceride (TG) and total cholesterol (TC) levels in laboratory animals (Wistar rats), comparing it with the induction of hypertriglyceridaemia and hypercholesterolaemia by Triton WR-1339 injection. The results show that Triton would be suitable for inducing hypercholesterolaemia but not hypertriglyceridaemias similar to those in humans. The LCT emulsion intake, however, provoked transitory hyperlipaemia with values similar to those often found in hyperlipaemic subjects, and would thus be suitable for testing possible antilipaemic treatments. Our study also presents a model of hypertriglyceridaemia, hypercholesterolaemia and obesity in experimental animals, provoked by a chronic intake of an LCT emulsion. This model may be useful in investigating the mechanisms of the pathogenesis of atherosclerosis and the pharmacological treatment of obesity and dyslipaemias.
Pérez
C
C
Department of Physiology, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
Canal
J R
JR
Romero
A
A
Torres
M D
MD
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D005217:Fat Emulsions, Intravenous; D005260:Female; D006937:Hypercholesterolemia / Q000097:blood / Q000139:chemically induced*; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced*; D009765:Obesity / Q000139:chemically induced; D011092:Polyethylene Glycols / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013501:Surface-Active Agents / Q000633:toxicity*; D014280:Triglycerides / Q000097:blood
D005217:Fat Emulsions, Intravenous; D013501:Surface-Active Agents; D014280:Triglycerides; D011092:Polyethylene Glycols; D002784:Cholesterol; C016811:tyloxapol