title: Increased expression of sialyl Le(x) antigen in non-polypoid growth type of colorectal carcinoma.
abstract: Colorectal carcinoma can be morphologically divided into two different categories, namely polypoid growth (PG-type) and non-polypoid growth (NPG-type). To ascertain whether the expression of sialyl Le(x) antigen correlates with biologically and clinically important differences, an immunohistochemical assay was performed in 30 PG-type and 119 NPG-type cancers. In contrast to PG-type, the characteristics of the NPG-type include (1) an increased expression of sialyl Le(x); (2) a high rate of lymph node metastasis; (3) a high proportion of moderately differentiated adenocarcinoma cells; (4) young age of onset. It is concluded that differences in sialyl Le(x) expression between the PG-type and NPG-type cancers may be at least partly responsible for different tumor progression behavior.
authors.affiliation: First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, Japan. nakagoe@net.nagasaki-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nakagoe
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: A
authors.initials: A
authors.lastname: Nanashima
authors.forename: T
authors.initials: T
authors.lastname: Sawai
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: M
authors.initials: M
authors.lastname: Jibiki
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Yasutake
authors.forename: H
authors.initials: H
authors.lastname: Ayabe
authors.forename: T
authors.initials: T
authors.lastname: Matuo
authors.forename: Y
authors.initials: Y
authors.lastname: Tagawa
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D017668:Age of Onset; D000368:Aged; D002454:Cell Differentiation; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016256:Lewis X Antigen / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009844:Oligosaccharides / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016016:Proportional Hazards Models; D000080506:Sialyl Lewis X Antigen; D015996:Survival Rate; D015854:Up-Regulation
chemical_list: D016256:Lewis X Antigen; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen