Understanding Ras: 'it ain't over 'til it's over'.
Since 1982, Ras has been the subject of intense research scrutiny, focused on determining the role of aberrant Ras function in human cancers and defining the mechanism by which Ras mediates its actions in normal and neoplastic cells. The long-term goal has been to develop antagonists of Ras as novel approaches for cancer treatment. Although impressive strides have been made in these endeavours, and our knowledge of Ras is quite extensive, it appears that we are at the beginning, rather than at the end, of fully understanding Ras function. This review highlights new issues that have further complicated our efforts to understand Ras.
Shields
J M
JM
Depts of Pharmacology and Cell Biology, and Anatomy, University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Pruitt
K
K
McFall
A
A
Shaub
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A
Der
C J
CJ
D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000502:physiology*; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D019908:Proto-Oncogene Proteins c-raf; D018631:ras Proteins; D020741:rho GTP-Binding Proteins