title: Bioactive terpenes from the soft coral Heteroxenia sp. from Mindoro, Philippines.
abstract: A marine soft coral species of the genus Heteroxenia collected from Mindoro Island, Philippines yielded two cadinene sesquiterpenes, (+)-alpha-muurolene (1) and a novel derivative (+)-6-hydroxy-alpha-muurolene (2), as well as the biologically active polyhydroxysterol, sarcoaldosterol A (3). The structure of the novel compound was unambiguously established on the basis of NMR spectroscopic (1H, 13C, COSY, 1H-detected direct and long range 13C-1H correlations) and mass spectrometric (EIMS) data. All compounds were active against the phytopathogenic fungus Cladosporium cucumerinum. The isolated terpenes were also active in the brine shrimp lethality test.
authors.affiliation: Julius-von-Sachs-Institut für Biowissenschaften, Lehrstuhl für Pharmazeutische Biologie, Würzburg, Germany.
authors.forename: R A
authors.initials: RA
authors.lastname: Edrada
authors.forename: V
authors.initials: V
authors.lastname: Wray
authors.forename: L
authors.initials: L
authors.lastname: Witte
authors.forename: L
authors.initials: L
authors.lastname: van Ofwegen
authors.forename: P
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D001156:Artemia; D002963:Cladosporium / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D010679:Philippines; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D018629:Spectrometry, Mass, Secondary Ion; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D012717:Sesquiterpenes; D013729:Terpenes