Supportive evidence for contribution of the dopamine D2 receptor gene to heritability of stature: linkage and association studies.
Increases in height were reported in children chronically exposed prenatally and postnatally to D2 receptor-blocking drugs. A possible haplotypic association between stature and the DRD2 gene was also reported. In this study, we examined linkage between stature and DRD2 by genotyping a dinucleotide repeat polymorphism in 79 sib-pairs aged 8-17 years. An association between stature and a putative functional polymorphism in the promoter region of the DRD2 gene was examined in the sib-pairs and in 125 unrelated male adults. All the subjects were Japanese. Linkage (p = 0.004, SIBPAL) and an association (p = 0.009, paired t-test, in the sib-pairs; p = 0.006, ANOVA, in the adults) with stature were suggested. These findings indicate that DRD2 is one of the genes that contribute to heritability of stature.
Arinami
T
T
Department of Medical Genetics, University of Tsukuba, Ibaraki, Japan. tarinami@md.tsukuba.ac.jp
Iijima
Y
Y
Yamakawa-Kobayashi
K
K
Ishiguro
H
H
Ohtsuki
T
T
Yanagi
H
H
Shimakura
Y
Y
Ishikawa
H
H
Hamaguchi
H
H
D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000235:genetics*; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D004247:DNA / Q000235:genetics; D018900:Dinucleotide Repeats / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D013223:Statistics as Topic
D017448:Receptors, Dopamine D2; D004247:DNA; D002784:Cholesterol