[Studies of local anesthetics. CL. Models of the dependence of local anesthetic effectiveness of basic esters of alkoxy-substituted phenylcarbamic acids on capacity factor k'].
On the basis of proposed six models of the dependence of local anaesthetic effectiveness of series of alkoxysubstituted derivatives of phenylcarbamic acid, this activity was studies in dependence on the capacity factor k' as the parameter of lipophilicity. The most suitable models proved to be y = (Cx + Ci).k' for surface anaesthesia, and y = Cx + Ci log k' for infiltration anaesthesia, y being the value of the decadic logarithm of surface or infiltration local anaesthetic activity, Cx the coefficient characterizing the nitrogenous base, Ci the coefficient characterizing the individual alkoxygroups, and k' the capacity factor from HPLC.
Cizmárik
J
J
Katedra farmaceutickej chémie, Farmaceutickej fakulty, Univerzity Komenského, Bratislava.
Lehotay
J
J
Bednáriková
A
A
Hrobonová
K
K
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D008954:Models, Biological; D008956:Models, Chemical
D000779:Anesthetics, Local; D002219:Carbamates; C059692:phenylcarbamic acid