Dermatomyositis accompanied by rectal cancer: report of a case.
Dermatomyositis (DM) is a rare inflammatory disorder of the skin and muscles associated with an increased incidence of malignancy. We describe herein the case of a 59-year-old woman with DM accompanied by rectal cancer. Following excision of the rectal cancer, the characteristic features of the skin rash such as the heliotrope eyelid rash and Gottron's papules, and proximal muscle weakness, improved. Moreover, the elevated preoperative serum levels of muscle-associated enzymes, including aspartate transaminase, creatine phosphokinase, lactate dehydrogenase, and aldolase, decreased from 38 to 16 (IU/1), 138 to 42 (IU/1), 672 to 515 (IU/1), and 32.2 to 4.3 (IU/1), respectively. The current concepts of the correlation between DM and malignancy are discussed with regard to the present case.
Fujii
K
K
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
Moriya
Y
Y
Fujita
S
S
Akasu
T
T
Miyake
H
H
Nakanishi
Y
Y
Saito
T
T
D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003882:Dermatomyositis / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D018482:Muscle, Skeletal / Q000201:enzymology; D012004:Rectal Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome