title: [Mastocytosis: an important differential diagnosis in anaphylactoid reaction to Hymenoptera sting. A case report and overview of clinical aspects, diagnosis and current therapy of mastocytosis].
abstract: A 77-year old farmer presented with a history of three severe anaphylactoid reactions after hymenoptera stings for the last three years. No sensitisation to hymenoptera venoms could be shown on allergological work-up. The serum level of tryptase however was clearly elevated (37.1 micrograms/l; normal value: < 13.5 micrograms/l). The diagnosis of systemic mastocytosis could be confirmed by bone marrow biopsy. Patients with mastocytosis are at increased risk of anaphylactic/anaphylactoid reactions. They should be educated how to avoid trigger factors and they should always carry an emergency kit (H1 blocker, corticosteroid, adrenalin) and a "mastocytosis pass" with them. Venom immunotherapy is indicated in patients with proven hymenoptera allergy. Selected patients at very high risk of anaphylactic reactions may need a continuous prophylactic medication with H1 and H2 blocker and eventually a cyclooxygenase inhibitor.
authors.affiliation: Dermatologische Klinik und Poliklinik, UniversitätsSpital Zürich.
authors.forename: C
authors.initials: C
authors.lastname: Bucher
authors.forename: P
authors.initials: P
authors.lastname: Simic
authors.forename: J
authors.initials: J
authors.lastname: Furrer
authors.forename: B
authors.initials: B
authors.lastname: Wüthrich
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000175:diagnosis*; D000818:Animals; D003937:Diagnosis, Differential; D006801:Humans; D006927:Hymenoptera; D007299:Insect Bites and Stings / Q000175:diagnosis*; D008297:Male; D008415:Mastocytosis / Q000175:diagnosis*