title: Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.
abstract: A reticular pattern on high resolution CT (HRCT) invariably represents significant lung pathology and is the dominant feature of irreversible fibrosis. We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis. Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.
authors.affiliation: Department of Radiology, Royal Brompton Hospital, London, England.
authors.forename: R E
authors.initials: RE
authors.lastname: Sheehan
authors.forename: A U
authors.initials: AU
authors.lastname: Wells
authors.forename: D G
authors.initials: DG
authors.lastname: Milne
authors.forename: D M
authors.initials: DM
authors.lastname: Hansell
mesh_terms: D000368:Aged; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D008297:Male; D009582:Nitrofurantoin / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000000981:diagnostic imaging; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed; D014552:Urinary Tract Infections / Q000188:drug therapy
chemical_list: D009582:Nitrofurantoin