title: Phenytoin-induced severe cutaneous drug reactions: suspected interactions with corticosteroids and H2-blockers.
abstract: BACKGROUND
  Cutaneous drug reactions are attributed usually to one culprit drug, however, some CDRs may be associated with drug interactions.
  
  
  OBJECTIVE
  To present a case series of four patients with phenytoin-induced severe CDRs, including toxic epidermal necrolysis (2 patients), exanthematous eruption (1 patient) and hypersensitivity syndrome (1 patient). In all patients the reactions appeared following the combined intake of phenytoin, corticosteroids and H2-blockers.
  
  
  CONCLUSIONS
  Our case series may imply the role of drug interactions between phenytoin, corticosteroids and H2-blockers in the induction of severe CDRs.
authors.affiliation: Department of Dermatology, Soroka Medical Center, Beer Sheva, Israel. arcohen@bgumail.bgu.ac.il
authors.forename: A D
authors.initials: AD
authors.lastname: Cohen
authors.forename: E
authors.initials: E
authors.lastname: Reichental
authors.forename: S
authors.initials: S
authors.lastname: Halevy
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D003875:Drug Eruptions / Q000209:etiology*; D004357:Drug Synergism; D005260:Female; D005938:Glucocorticoids; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006635:Histamine H2 Antagonists; D010672:Phenytoin