[The effects of menopausal replacement therapy in women with uterine myomas].
BACKGROUND
The aim of this study was to compare the effects of two different therapies in menopausal women with uterine fibroids.


METHODS
Thirty menopausal women with uterine fibroids were evaluated. They were randomized into two groups: the patients included in Group A were treated with transdermal hormonal therapy with 50 micrograms of ethynilestradiol and 5 mg of MAP; the patients in Group B with 2.5 mg of tibolone. The patients of both the groups have been treated for one year. Plasmatic levels of E2, FSH and LH were evaluated before and after treatment and the volume of fibroids was compared by transvaginal ultrasonography at the beginning of the study, after 6 months and after 1 year.


CONCLUSIONS
The results suggest that transdermal hormonal therapy increases significantly the volume of the fibroids while tibolone does not.
Orsini
G
G
III Clinica Ostetrica e Ginecologica, Università degli Studi, Bari.
Pinto
V
V
Di Biase
S
S
D'Altorio
C
C
Lanzilotti
G
G
D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000097:blood / Q000188:drug therapy*; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009652:Norpregnenes / Q000008:administration & dosage; D013997:Time Factors; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy*
D018931:Antineoplastic Agents, Hormonal; D009652:Norpregnenes; D004958:Estradiol; D017258:Medroxyprogesterone Acetate; C027385:tibolone