title: Comparison of HIG scintigraphy and bloodpool scintigraphy using HDP in arthritic joint disease.
abstract: OBJECTIVE
  Because of a similar tracer accumulation, we assumed to get the same information about synovitis in arthritic joint disease with HIG scintigraphy and bloodpool scintigraphy using HDP. Therefore, we compared retrospectively 23 patients.
  
  
  METHODS
  In HIG scintigraphy, synovitis was diagnosed according to increasing activity from early to late image. In bloodpool scintigraphy according to an increased activity in comparison to the surrounding tissues.
  
  
  RESULTS
  In 694 joints comparison of both scintigraphic modalities was possible, resulting in a 2 x 2 kappa coefficient of 0.93 or 0.97 by using late-phase bone scintigraphy as an anatomical marker. For intra- and interobserver agreement, 2 x 2 kappa coefficients of 0.93 and 0.88 in HIG scintigraphy, respectively 0.96 and 0.90 in blood-pool scintigraphy were calculated.
  
  
  CONCLUSIONS
  This study shows an excellent agreement in the visualization of synovitis by HIG and bloodpool scintigraphy. Because of its higher objectivity and lower cost, investigation of synovitis should be performed by bloodpool scintigraphy.
authors.affiliation: Klinik für Nuklearmedizin, Klinikum der Justus-Liebig-Universität Giessen, Deutschland.
authors.forename: R
authors.initials: R
authors.lastname: Klett
authors.forename: K
authors.initials: K
authors.lastname: Grau
authors.forename: M
authors.initials: M
authors.lastname: Puille
authors.forename: H P
authors.initials: HP
authors.lastname: Matter
authors.forename: U
authors.initials: U
authors.lastname: Lange
authors.forename: D
authors.initials: D
authors.lastname: Steiner
authors.forename: R
authors.initials: R
authors.lastname: Bauer
mesh_terms: D000328:Adult; D000368:Aged; D001168:Arthritis / Q000000981:diagnostic imaging*; D015535:Arthritis, Psoriatic / Q000000981:diagnostic imaging; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005260:Female; D015902:Gamma Cameras; D006801:Humans; D007136:Immunoglobulins; D008193:Lyme Disease / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging; D013667:Technetium; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives*
chemical_list: D007136:Immunoglobulins; D019275:Radiopharmaceuticals; C065376:technetium Tc 99m immunoglobulin; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D013669:Technetium Tc 99m Medronate