title: Balloon angioplasty of native coarctation: clinical outcomes and predictors of success.
abstract: OBJECTIVE
  We sought to investigate the clinical impact of balloon angioplasty for native coarctation of the aorta (CoA) and determine predictors of outcome.
  
  
  BACKGROUND
  Balloon dilation of native CoA remains controversial and more information on its long-term impact is required.
  
  
  METHODS
  Hemodynamic, angiographic and follow-up data on 69 children who underwent balloon angioplasty of native CoA between 1988 and 1996 were reviewed. Stretch, recoil and gain of CoA circumference and area were calculated and related to outcomes.
  
  
  RESULTS
  Initial systolic gradients (mean +/- SD, 31+/-12 mm Hg) fell by -74+/-27% (p < 0.001), with an increase in mean CoA diameters of 128+/-128% in the left anterior oblique and 124+/-87% in the lateral views (p < 0.001). Two deaths occurred, one at the time of the procedure and one 23 months later, both as a result of an associated cardiomyopathy. Seven patients had residual gradients of >20 mm Hg. One patient developed an aneurysm, stable in follow-up, and four patients had mild dilation at the site of the angioplasty. Freedom from reintervention was 90% at one year and 87% at five years with follow-up ranging to 8.5 years. Factors significantly associated with decreased time to reintervention included: a higher gradient before dilation, a smaller percentage change in gradient after dilation, a small transverse arch and a greater stretch and gain, but not recoil.
  
  
  CONCLUSIONS
  Balloon dilation is a safe and efficient treatment of native CoA in children. Greater stretch and gain are factors significantly associated with reintervention, possibly related to altered elastic properties and vessel scarring.
authors.affiliation: Department of Pediatrics, University of Toronto School of Medicine, Canada. ovaert@pedi.ucl.ac.be
authors.forename: C
authors.initials: C
authors.lastname: Ovaert
authors.forename: B W
authors.initials: BW
authors.lastname: McCrindle
authors.forename: D
authors.initials: D
authors.lastname: Nykanen
authors.forename: C
authors.initials: C
authors.lastname: MacDonald
authors.forename: R M
authors.initials: RM
authors.lastname: Freedom
authors.forename: L N
authors.initials: LN
authors.lastname: Benson
mesh_terms: D000800:Angioplasty, Balloon; D001017:Aortic Coarctation / Q000503:physiopathology / Q000628:therapy*; D001027:Aortography; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008297:Male; D019233:Retreatment; D013599:Systole / Q000502:physiology; D016896:Treatment Outcome; D014655:Vascular Resistance / Q000502:physiology