title: [Major pulmonary embolism].
abstract: The diagnosis of major pulmonary embolism should be considered in case of acute respiratory distress, particularly when there is high thromboembolic risk. Although clinical symptoms are not specific, some are suggestive: syncope or dizziness with cyanosis and polypnoea, and especially arterial hypotension and cardiogenic shock. Diagnostic workup should be rapid and straight forward. Transthoracic echography is particularly useful to detect right heart thrombi and right ventricular overload. More information could be provided by helical computed tomography or perfusion lung scan or less commonly now by pulmonary angiography, depending on the patient's clinical condition and the available equipment. The mortality rate can reach 20 to 30%, and up to 65% after resuscitated cardiac arrest. Rapid desobstruction is justified through surgical embolectomy or intravenous thrombolysis favouring short duration protocols (alteplase over 2 h), in spite of the bleeding risk.
authors.affiliation: Cardiologie D, unité de soins cardiaques intensifs CHRU de Tours Hôpital Trousseau, Tours.
authors.forename: B
authors.initials: B
authors.lastname: Charbonnier
mesh_terms: D000792:Angiography; D003937:Diagnosis, Differential; D004452:Echocardiography; D017128:Embolectomy; D004632:Emergency Medical Services; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006323:Heart Arrest / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D011379:Prognosis; D011655:Pulmonary Embolism / Q000175:diagnosis* / Q000628:therapy; D018570:Risk Assessment
chemical_list: D005343:Fibrinolytic Agents