title: Haemodynamic, acid-base and electrolyte changes during plasma replacement with hydroxyethyl starch or crystalloid solution in young pigs.
abstract: We investigated haemodynamic, acid-base and electrolyte changes during almost total plasma replacement with hydroxyethyl starch (HES) and physiological balanced electrolyte solution (PBE) by using a cell saver in ten young pigs. In the PBE group an additional 3550 (444) ml crystalloid solution [Mean (SD)] was infused over the course of the study in order to maintain pulmonary capillary wedge pressure. Plasma protein levels decreased in both groups and the colloid osmotic pressure increased in HES and decreased in PBE. At the end of the study, body weight [HES 10.4 (1), PBE 13.1 (1.4) kg, P < 0.01] and lactic acid concentration [HES 0.9 (0.3), PBE 2.9 (1. 3) mmol.l -1, P < 0.01] was higher and tissue oxygen delivery [HES 327 (22), PBE 89 (29) ml.min.m2, P < 0.01] was lower in the PBE group. There were only moderate acid-base changes in both groups, but at the end, anion gap was significant lower in HES. In conclusion, maintenance of colloid osmotic pressure close to the physiological range of infants seems to be advantageous during major paediatric surgery.
authors.affiliation: Anästhesie III, Medizinische Hochschule Hannover, 30625 Hannover, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Sümpelmann
authors.forename: T
authors.initials: T
authors.lastname: Schürholz
authors.forename: G
authors.initials: G
authors.lastname: Marx
authors.forename: E
authors.initials: E
authors.lastname: Thorns
authors.forename: J
authors.initials: J
authors.lastname: Hausdörfer
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001804:Blood Transfusion, Autologous / Q000295:instrumentation; D001835:Body Weight; D003102:Colloids; D000077324:Crystalloid Solutions; D005260:Female; D006400:Hematocrit; D006439:Hemodynamics / Q000502:physiology*; D006454:Hemoglobins / Q000032:analysis; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007552:Isotonic Solutions; D019344:Lactic Acid / Q000097:blood; D009997:Osmotic Pressure; D010100:Oxygen / Q000097:blood; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D015532:Rehydration Solutions / Q000627:therapeutic use*; D013223:Statistics as Topic; D013552:Swine; D014655:Vascular Resistance / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D001798:Blood Proteins; D003102:Colloids; D000077324:Crystalloid Solutions; D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D015532:Rehydration Solutions; D019344:Lactic Acid; D010100:Oxygen