Mechanisms of angiogenesis and arteriogenesis.
Endothelial and smooth muscle cells interact with each other to form new blood vessels. In this review, the cellular and molecular mechanisms underlying the formation of endothelium-lined channels (angiogenesis) and their maturation via recruitment of smooth muscle cells (arteriogenesis) during physiological and pathological conditions are summarized, alongside with possible therapeutic applications.
Carmeliet
P
P
The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B-3000, Belgium. peter.carmeliet@med.kuleuven.ac.be
D000818:Animals; D001160:Arterioles / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000254:growth & development; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology