High bone mass and hypocalcaemic myopathy in a patient with idiopathic hypoparathyroidism.
The clinical manifestations of hypoparathyroidism are mainly characterised by increased neuromuscular irritability as a consequence of hypocalcaemia. Occasionally, elevation of the muscle enzymes may mimic polymyositis. Reduced parathyroid hormone production, but also vitamin D treatment and calcium supplementation, may contribute to the increased bone mass found in patients with postsurgical hypoparathyroidism. We report the case of a 36-year-old woman with untreated idiopathic hypoparathyroidism and a high bone mass despite severe muscle impairment due to hypocalcaemic myopathy.
Van Offel
J F
JF
Department of Immunology, Allergy and Rheumatology, University Hospital of Antwerp, Belgium. jan.vanoffel@uia.ua.ac.be
De Gendt
C M
CM
De Clerck
L S
LS
Stevens
W J
WJ
D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D002762:Cholecalciferol / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004576:Electromyography; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D007011:Hypoparathyroidism / Q000150:complications* / Q000378:metabolism; D009135:Muscular Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism
D002762:Cholecalciferol; D002118:Calcium