[Preliminay studies on polyvinyl alcohol gel and its transderman therapeutic system].
By pouring-cooling method, five kinds of hydrophilic gels (starch, agar, gelatin, CMC-Na and PVA) were prepared. The characteristics of preparation, tenacity and elasticiey were compared. Taking the PVA gel which features better characteristics as the carrier a plaster of verapamine hydrochloride and a traditional Chinese antitussive and expectorant in the form of plaster were prepared. The behavior of drug-releasing in vitro and curative effect were preliminarily studied. The results show that the PVA gel may be a fine carrier for transdermal therapeutic system.
Lin
Y
Y
Guiyang College of Traditional Chinese Medicine.
Zhou
J
J
Zhu
X
X
D000279:Administration, Cutaneous; D000818:Animals; D000996:Antitussive Agents / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005782:Gels; D006168:Guinea Pigs; D006801:Humans; D009823:Ointment Bases; D009824:Ointments; D011142:Polyvinyl Alcohol; D011817:Rabbits
D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; D005782:Gels; D009823:Ointment Bases; D009824:Ointments; D011142:Polyvinyl Alcohol