title: The risk of premalignant and malignant pathology in endometrial polyps.
abstract: OBJECTIVE
  To evaluate the risk of premalignant and malignant pathology among endometrial polyps.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Minimal Access Surgical Training (MAST) center in a large teaching hospital.
  
  
  METHODS
  Among 248 patients seen in outpatient hysteroscopy clinic (1996-97), 62 had endometrial polyps. All patients had endometrial sampling for histological assessment. To determine the magnitude of malignant potential among polyps, we compared the pathological findings in polyps (cases) with non-polypoidal specimens (controls).
  
  
  RESULTS
  Out of 62 polyps, histologically 53 (85.5%) were benign, seven (11.3%) had hyperplasia, and two (3.2%) were associated with malignancy. Hyperplasia was more frequent in endometrial specimens with polyps than in those without (11.3% vs 4.3%, p=0.04), but the incidence of carcinoma in the two groups was the same (3.2% vs 3.2%, p= 1.0).
  
  
  CONCLUSIONS
  In abnormal uterine bleeding, hyperplasia was, but cancer was not, more common in women with endometrial polyps compared to those without polyps.
authors.affiliation: Birmingham Minimal Access Surgical Training Centre, Academic Department of Obstetrics and Gynaecology, University of Birmingham, UK.
authors.forename: S H
authors.initials: SH
authors.lastname: Bakour
authors.forename: K S
authors.initials: KS
authors.lastname: Khan
authors.forename: J K
authors.initials: JK
authors.lastname: Gupta
mesh_terms: D015331:Cohort Studies; D004714:Endometrial Hyperplasia / Q000209:etiology / Q000473:pathology; D016889:Endometrial Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D011127:Polyps / Q000150:complications / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D011446:Prospective Studies; D018570:Risk Assessment; D014591:Uterine Diseases / Q000473:pathology*; D014592:Uterine Hemorrhage / Q000209:etiology / Q000473:pathology