[Prevalence of genetic variants of luteinizing hormone in the Czech Republic].
BACKGROUND
The relatively common genetic variant of LH beta-subunit, resulting in changes of the pituitary-gonadal axis, displays different prevalence in various ethnic populations.


RESULTS
Frequency of occurrence of the variant allele in our country has been determined by analysis of LH in a randomly selected population group from the Cheb region, comprising of 257 subjects (82 men and 175 women) in the age from 14 to 72 years. The LH variant was determined by a novel immunofluorescence method, based on two assays, of which the first detected the wild type of the hormone and its variant, while the second was specific for the wild type of LH only. The frequency of carriers of the variant allele for LH-beta-subunit amounted to 17.5%, i.e. 12.2% in males and 20.6% in females.


CONCLUSIONS
The prevalence of the variant allele for LH-beta-subunit in the investigated region of West Bohemia was close to that of other Antral European and North European populations.
Stárka
L
L
Endokrinologický ústav, Praha.
Hill
M
M
Hampl
R
R
Huhtaniemi
I T
IT
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D018153:Czech Republic; D005260:Female; D005455:Fluorescent Antibody Technique; D005787:Gene Frequency; D014644:Genetic Variation; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D007986:Luteinizing Hormone