title: Effects of portal versus systemic venous drainage in kidney-pancreas recipients.
abstract: A randomized study of combined kidney-pancreas transplantation was performed on 30 insulin-dependent diabetic patients with end-stage renal disease to compare the consequences of pancreas transplantation with portal venous (PV) and systemic venous (SV) drainage. Fourteen patients (SV) group) received systemically drained and sixteen (PV group) portally drained pancreas allografts. Enteric drainage was performed in both groups. The routine follow-up included documentation of the clinical course and detailed endocrine studies. At 1 year after transplantation, the patient survival rate was 92% for the SV group and 96% for the PV group; the graft survival rate was 78% and 82%, respectively. Endocrine studies indicated no difference in fasting and stimulated glucose or in glycosylated hemoglobin between the two groups. In addition, no hyperinsulinemia and lipidic abnormalities were evidenced in either group Long-term studies are required to conclude whether PV and SV drainage in pancreas transplantation are equivalent in terms of patient and graft survival as well as metabolic consequences.
authors.affiliation: Service de Chirurgie de la Transplantation, Hôpital Edouard Herriot, Lyon, France.
authors.forename: X
authors.initials: X
authors.lastname: Martin
authors.forename: P
authors.initials: P
authors.lastname: Petruzzo
authors.forename: M
authors.initials: M
authors.lastname: Dawahra
authors.forename: L C
authors.initials: LC
authors.lastname: Feitosa Tajra
authors.forename: M
authors.initials: M
authors.lastname: Da Silva
authors.forename: L
authors.initials: L
authors.lastname: Pibiri
authors.forename: F
authors.initials: F
authors.lastname: Chapuis
authors.forename: J M
authors.initials: JM
authors.lastname: Dubernard
authors.forename: N
authors.initials: N
authors.lastname: Lefrançois
mesh_terms: D000328:Adult; D000714:Anastomosis, Surgical / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery; D003928:Diabetic Nephropathies / Q000601:surgery; D004322:Drainage; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000379:methods* / Q000502:physiology; D011169:Portal Vein / Q000601:surgery*; D014280:Triglycerides / Q000097:blood; D014680:Veins / Q000601:surgery
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol