Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.
To investigate the nature of the link between Helicobacter pylori (Hp) infection and stomach carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. MGs were treated with N-methyl-N-nitrosourea (MNU), followed by inoculation with Hp (groups 1 and 2) or without Hp (group 3), or infected with Hp (groups 4 and 5) or inoculation without Hp (group 6) followed by MNU administration. At week 21, the animals in groups 2 and 5 underwent an eradication procedure. At week 50, the incidences of adenocarcinomas in group 1 (15 of 23) and group 4 (9 of 26) were significantly higher than in group 3 (1 of 15) and group 6 (1 of 18), respectively. Moreover, those in group 2 (5 of 24) and group 5 (2 of 22) were lower than in groups 1 and 4, respectively. This study shows that Hp eradication may be useful as a prevention approach against stomach cancer.
Shimizu
N
N
Laboratory of Pathology, Aichi Cancer Center Research Institute, Japan.
Ikehara
Y
Y
Inada
K
K
Nakanishi
H
H
Tsukamoto
T
T
Nozaki
K
K
Kaminishi
M
M
Kuramoto
S
S
Sugiyama
A
A
Katsuyama
T
T
Tatematsu
M
M
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D018279:Carcinoma, Signet Ring Cell / Q000139:chemically induced / Q000473:pathology; D003043:Cocarcinogenesis; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000187:drug effects*; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity; D011706:Pyloric Antrum / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate
D002273:Carcinogens; D008770:Methylnitrosourea