Systematic reviews on leptospirosis.
OBJECTIVE
To find the existing clinical evidence on interventions for leptospirosis. The objective is to evaluate the effectiveness and safety of any intervention on leptospirosis through systematic reviews of randomized controlled trials (RCTs).


METHODS
The sources of studies used (where there were no limitations concerning language, date, or other restrictions) were: EMBASE, LILACS, MEDLINE, the Cochrane Controlled Clinical Trials Database, and the Cochrane Hepato-Biliary Group Randomized Trials register.


METHODS



METHODS
All systematic reviews of randomized controlled trials.


METHODS
patients with clinical and/or laboratorial diagnosis of leptospirosis, and subjects potencially exposed to leptospirosis as defined by the authors


METHODS
any intervention for leptospirosis (as antibiotics or vaccines for prevention or treatment).


METHODS
The assessment will be independently made by the reviewers and cross-checked. The external validity was assessed by analysis of: studies, interventions, and outcomes.


RESULTS
Located 163 studies using the search strategy described above, at the electronic databases above. Only 2 hits were selected, which are protocols of systematic reviews of Cochrane Collaboration, and not full reviews. One of the protocols evaluates antibiotics for treatment, and the other evaluates antibiotics for prevention of leptospirosis.


CONCLUSIONS
There were not complete systematic reviews on interventions for leptospirosis. Any interventions for leptospirosis, such as prevention and treatment remains unclear for guidelines and practice.
Guidugli
F
F
Federal University of São Paulo, SP, Brazil.
Castro
A A
AA
Atallah
A N
AN
D016206:Databases, Bibliographic; D019317:Evidence-Based Medicine; D006801:Humans; D007922:Leptospirosis / Q000628:therapy*; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic