Hyperphagia and self-mutilation in Prader-Willi syndrome: psychopharmacological issues.
This study focused in the treatment of two major Prader-Willi symptoms: hyperphagia and self-injurious behavior (SIB). Four patients participated in a four-year study with monthly follow-ups. Patients lived in a behaviorally structured environment, and were treated with selective serotonin reuptake blockers and phenothiazines. Psychopharmacological intervention improved SIB symptoms, but was ineffective to control appetite satiation.
Yaryura-Tobias
J A
JA
Department of Biopsychosocial Research Institute for Biobehavioral Therapy and Research, Great Neck, NY 11021, USA.
Grunes
M S
MS
Bayles
M E
ME
Neziroglu
F
F
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001066:Appetite / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006963:Hyperphagia / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000523:psychology; D010640:Phenothiazines; D011218:Prader-Willi Syndrome / Q000188:drug therapy* / Q000523:psychology; D012528:Satiety Response / Q000187:drug effects; D012652:Self Mutilation / Q000188:drug therapy* / Q000523:psychology; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D010640:Phenothiazines; D017367:Selective Serotonin Reuptake Inhibitors