Direct effects of lithium chloride on the activities of delta 5-3 beta and 17 beta-hydroxysteroid dehydrogenase in the testis and Bidder's organ of the adult toad (Bufo melanostictus)--in vitro study.
Steroidogenic key enzymes, i.e. delta 5-3 beta and 17 beta-hydroxysteroid dehydrogenase (delta 5-3 beta and 17 beta-HSD) activities, in the testis and Bidder's organ of the toad were inhibited and ascorbic acid synthesis in these organs was decreased by a wide range of lithium concentration in in vitro study. A significant inhibition was noted at a concentration of 2.0 mM, which is easily achieved in the blood during the treatment of manic patients by lithium chloride. This experiment reflected that lithium exerts a direct inhibitory effect on hydroxysteroid dehydrogenase activities in the testis and Bidder's organ--a rudimentary ovary in Bufo.
Nandi
D K
DK
Department of Human Physiology with Community Health, Vidyasagar University, West Bengal, India.
Debnath
J M
JM
Ghosh
D
D
D015067:17-Hydroxysteroid Dehydrogenases / Q000187:drug effects / Q000378:metabolism*; D015096:3-Hydroxysteroid Dehydrogenases / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D018692:Antimanic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D002025:Bufonidae / Q000502:physiology; D018021:Lithium Chloride / Q000494:pharmacology*; D008297:Male; D013737:Testis / Q000187:drug effects* / Q000502:physiology
D018692:Antimanic Agents; D015067:17-Hydroxysteroid Dehydrogenases; D015096:3-Hydroxysteroid Dehydrogenases; C031954:delta(5)-3 beta-hydroxysteroid dehydrogenase; C044256:3 (or 17)-beta-hydroxysteroid dehydrogenase; D018021:Lithium Chloride; D001205:Ascorbic Acid