The use of ebastine, a mast cell blocker, for treatment of oligozoospermia.
The effect of mast cell blocker (ebastine) on semen quality was evaluated in 15 idiopathic oligozoospermic males. Ten milligrams/day of ebastine was administered orally for 3 months. Nine cases (66.7%) showed definite improvement in the semen quality. The wives of 3 patients (20%) became pregnant within 6 months of the initial treatment. It would appear that mast cell blocker (ebastine) significantly improves semen quality in men with idiopathic oligozoospermia.
Matsuki
S
S
Department of Urology, Yamagata University School of Medicine, Japan.
Sasagawa
I
I
Suzuki
Y
Y
Yazawa
H
H
Tateno
T
T
Hashimoto
T
T
Nakada
T
T
Saito
H
H
Hiroi
M
M
D000328:Adult; D002090:Butyrophenones / Q000627:therapeutic use*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D008875:Middle Aged; D009845:Oligospermia / Q000188:drug therapy*; D010880:Piperidines / Q000627:therapeutic use*
D002090:Butyrophenones; D006634:Histamine H1 Antagonists; D010880:Piperidines; C058249:ebastine