Pyogenic granuloma of the tongue early after allogeneic bone marrow transplantation for multiple myeloma.
Oral complications occur frequently after bone marrow transplantation (BMT). Some of them are caused by regimen-related toxicity of the preparative regimen, and others by infections. In addition, oral tissues are targets of graft-versus-host disease (GVHD). Oral granulomatous lesions are not a common complication after BMT, and are especially rare on the tongue. Such rare lesions reported in the literature, developed late after BMT with oral chronic GVHD. We present here a patient who developed pyogenic granuloma of the tongue early after allogeneic BMT done for multiple myeloma. Regimen-related mucositis, oral acute GVHD, the administration of cyclosporine A, and the preexisting macroglossia might be responsible for the formation of granuloma.
Kanda
Y
Y
Department of Hematology, International Medical Center of Japan, Tokyo. ycanda-tky@umin.ac.jp
Arai
C
C
Chizuka
A
A
Suguro
M
M
Hamaki
T
T
Yamamoto
R
R
Yamauchi
Y
Y
Matsuyama
T
T
Takezako
N
N
Shirai
Y
Y
Miwa
A
A
Iwasaki
K
K
Nasu
M
M
Togawa
A
A
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D017789:Granuloma, Pyogenic / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000628:therapy*; D014060:Tongue Diseases / Q000209:etiology*; D014184:Transplantation, Homologous