Genetic markers of immunoglobulins and diabetes mellitus in the multiracial population of New Caledonia. The CALDIA Study Group.
GM and KM immunoglobulin allotypes, which are the markers, respectively, of the constant parts of the heavy and the light chains of the IgG1, IgG2 and IgG3 subclasses, have been analysed in diabetic mellitus patients and controls living in New Caledonia. We tested 40 Europeans, 256 Melanesians and 44 Polynesians, as well as their 340 matched controls, in order to search for a genetic susceptibility at those polymorphic loci. All the subjects were tested for G1M (1, 2, 3, 17), G2M (23), G3M (5, 6, 10, 11, 13, 14, 15, 16, 21, 24, 28) and KM (1) by the classical hemagglutination method. The frequencies of GM haplotypes and KM alleles have been estimated by a maximum likelihood method. The results are in favour of no influence of the GM and KM loci. The prevalence of diabetes mellitus varies in the populations of New Caledonia: Polynesians are at much higher risk than Melanesians or Europeans. The GM haplotype distribution differs among ethnic groups; so they provide a useful marker to measure genetic admixture. The higher prevalence of diabetes observed among New Caledonians of European origin compared to the prevalence in Europe may be explained by genetic admixture with neighbouring Pacific populations, notably Polynesians (Asian haplotypes are present at a frequency of 9.4%). So, the genetic admixture should be measured in any genetic epidemiological study.
Dugoujon
J M
JM
CNRS, ERS 1590, Unité de Physiopathologie Cellulaire et Moléculaire, Hopital Purpan, Toulouse, France. jean-michel_dugoujon@immgen.cnrs.fr
Guitard
E
E
Sénégas
M T
MT
Roth
M P
MP
Sanchez
A
A
Barny
S
S
Simon
D
D
Papoz
L
L
D000328:Adult; D044383:Black People; D016022:Case-Control Studies; D018864:Cultural Diversity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D005060:Europe / Q000208:ethnology; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D016013:Likelihood Functions; D008297:Male; D008403:Mass Screening; D008542:Melanesia / Q000208:ethnology; D008875:Middle Aged; D009510:New Caledonia / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011114:Polynesia / Q000208:ethnology; D015995:Prevalence; D044465:White People
D005819:Genetic Markers; D007126:Immunoglobulin Allotypes; D007129:Immunoglobulin Gm Allotypes