[Pancreatic anatomopathologic changes in chronic chagasic women. Preliminary data].
The aim of this study was to compare the frequency of pancreas morphologic and morphometric changes in chagasic women (n = 6) aged > or = 40 years, with non-chagasic controls (n = 4), paired concerning to age (59.8 +/- 11.5 versus 59.0 +/- 6.3 years), white color (33.3% versus 50.0%) and body mass index (22.3 +/- 7.0 versus 18.8 +/- 2.1 kg/m2). There were no pancreatic morphometric differences between necropsied chagasic and control groups. However, there was a smaller intrapancreatic neuronal population and a higher frequency of leukocyte perineural infiltrate in the pancreas of chagasic women. This possible intrapancreatic denervation could be associated with changes in carbohydrate metabolism, including hyperglycemia and diabetes mellitus, in some chronic chagasic women.
dos Santos
V M
VM
Departamento de Clínica Médica da Faculdade de Medicina do Triângulo Mineiro, FTTM, Uberaba, MG.
Teixeira
V de P
Vde P
da Cunha
D F
DF
da Cunha
S F
SF
Monteiro
J P
JP
dos Santos
J A
JA
dos Santos
T A
TA
dos Santos
L A
LA
D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D014355:Chagas Disease / Q000473:pathology*; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000473:pathology*; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000473:pathology; D008875:Middle Aged; D010179:Pancreas / Q000294:innervation / Q000473:pathology*; D012189:Retrospective Studies