[The effect of the expression of BHRF1 gene of EB virus on the proliferation of the cells of nasopharyngeal carcinoma].
In order to learn the effect of the expression of BHRF1 of Epstein-Barr virus on the growth of the cell of nasopharyngeal carcinoma, high BHRF1 expressive vector was set up and transfected in low grade cell line of nasopharyngeal carcinoma, CNE2. Then the cells were cultivated under the condition of insufficient nutrition. The results show that the BHRF1 expression can prohibit the expression of PCNA, and enhance the survival of tumor cells under conditions of nutrition deprivation. So, it suggests that BHRF1 of EB virus could be involved in the development of nasopharyngeal carcinoma.
Huang
H
H
Changhai Hospital, Second Military Medical University, Shanghai.
Pan
X
X
Sun
X
X
D002455:Cell Division; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D014162:Transfection; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000096:biosynthesis* / Q000235:genetics
C083278:BHRF1 protein, Human herpesvirus 4; D018809:Proliferating Cell Nuclear Antigen; D014764:Viral Proteins