title: One antigen mismatched related donor bone marrow transplant in a patient with acute lymphoblastic leukaemia and beta-thalassaemia major: potential cure of both marrow disorders.
abstract: We report a case of a 34-year-old man with T-ALL and beta-thalassaemia major who underwent a one antigen mismatched related donor bone marrow transplant. Five months post transplant chimeric studies revealed full donor haemopoiesis and the patient remains leukaemia and thalassaemia free at 12 months post transplant. Cumulative risk factors contributing to the increased transplant-related mortality in patients with two different marrow disorders are discussed.
authors.affiliation: Department of Haematology, University College London Hospitals, London, UK.
authors.forename: P D
authors.initials: PD
authors.lastname: Kottaridis
authors.forename: K
authors.initials: K
authors.lastname: Peggs
authors.forename: A
authors.initials: A
authors.lastname: Lawrence
authors.forename: S
authors.initials: S
authors.lastname: Verfuerth
authors.forename: R
authors.initials: R
authors.lastname: Chatterjee
authors.forename: P
authors.initials: P
authors.lastname: Telfer
authors.forename: J B
authors.initials: JB
authors.lastname: Porter
authors.forename: S
authors.initials: S
authors.lastname: Mackinnon
authors.forename: A H
authors.initials: AH
authors.lastname: Goldstone
mesh_terms: D000328:Adult; D001788:Blood Grouping and Crossmatching / Q000009:adverse effects*; D001855:Bone Marrow Diseases / Q000276:immunology / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D018572:Disease-Free Survival; D006115:Greece / Q000208:ethnology; D006801:Humans; D007519:Isoantigens / Q000009:adverse effects; D008297:Male; D018895:Microsatellite Repeats; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000276:immunology / Q000628:therapy*; D012307:Risk Factors; D014019:Tissue Donors; D018183:Transplantation Chimera; D014184:Transplantation, Homologous; D017086:beta-Thalassemia / Q000150:complications / Q000276:immunology / Q000628:therapy*
chemical_list: D007519:Isoantigens