A paradoxical rise of neonatal seizures after treatment with vitamin B6.
We report the case of a newborn with intractable epileptic seizures developing a paradoxical rise of seizure frequency and electroencephalogram alterations after administration of vitamin B6. We have been unable to determine the aetiology of this disorder. In a newborn presenting with drug-resistant epileptic seizures, the first therapeutic option remains the application of intravenous pyridoxine, but the physician should be aware of the risk of an increase in seizure frequency.
Hammen
A
A
Department of Neurology, University Hospital Bern, Switzerland.
Wagner
B
B
Berkhoff
M
M
Donati
F
F
D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D010507:Periodicity; D011736:Pyridoxine / Q000009:adverse effects*
D011736:Pyridoxine