title: Psychological functioning and quality of life following bone marrow transplantation: a 3-year follow-up study.
abstract: OBJECTIVE
  To assess changes in quality of life and psychological distress following bone marrow transplantation (BMT) and variables related to this change.
  
  
  METHODS
  One hundred twenty-five consecutive patients who underwent bone marrow transplantation (BMT) at the Leiden University Medical Centre between 1987 and 1992 filled in questionnaires measuring quality of life, functional limitations, psychological distress, anxiety, depression, self-esteem, and health locus of control. Measurements were taken before the BMT; 1 month after discharge; and 6 months, 1 year, and 3 years after the BMT.
  
  
  RESULTS
  Three years after BMT, a quarter of the patients continued to experience serious functional limitations. Thirteen percent of the patients scored >4 on the General Health Questionnaire (GHQ-12), a percentage comparable to general population prevalence. Quality of life was reported to be good to excellent by almost 90% of the patients at three years. Changes in quality of life could be explained entirely by changes in functional limitations and somatic symptoms. Changes in psychological distress were also related to these measures, and furthermore to baseline psychological functioning.
  
  
  CONCLUSIONS
  Although patients were doing well three years after BMT, there was a group of patients needing help. In interventions special attention should be given to patients with ongoing psychological problems. Emphasis should be on coping with physical limitations.
authors.affiliation: Department of Psychiatry, Leiden University Medical Centre, Oegstgeest, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Broers
authors.forename: A A
authors.initials: AA
authors.lastname: Kaptein
authors.forename: S
authors.initials: S
authors.lastname: Le Cessie
authors.forename: W
authors.initials: W
authors.lastname: Fibbe
authors.forename: M W
authors.initials: MW
authors.lastname: Hengeveld
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000523:psychology; D008223:Lymphoma / Q000523:psychology; D008297:Male; D009426:Netherlands; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D013315:Stress, Psychological / Q000523:psychology*; D016019:Survival Analysis