title: A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana.
abstract: Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone-A (1). Its structure was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.
authors.affiliation: National Research Institute of Chinese Medicine, and Chinese Culture University, Taipei, Taiwan, ROC.
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: S Y
authors.initials: SY
authors.lastname: Hwang
authors.forename: Y C
authors.initials: YC
authors.lastname: Shen
authors.forename: Y L
authors.initials: YL
authors.lastname: Lee
authors.forename: L
authors.initials: L
authors.lastname: Shyh-Yuan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013624:Taiwan; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; C409645:taiwanhomoflavone A