title: Decatromicins A and B, new antibiotics produced by Actinomadura sp. MK73-NF4. II. Structure determination.
abstract: The structures of decatromicins A and B that strongly inhibit the growth of MRSA were elucidated by the analysis of various NMR experiments. The planar structure was determined by 1H, 13C, COSY, HMQC and HMBC NMR spectra. The relative configuration of aglycone was elucidated by NOESY experiments and the absolute structure was determined by application of the modified Mosher's method. The absolute structure of glycosyl moiety was determined by X-ray analysis of the O-(p-bromobenzoyl) derivative.
authors.affiliation: Institute of Microbial Chemistry, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Momose
authors.forename: S
authors.initials: S
authors.lastname: Hirosawa
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Naganawa
authors.forename: H
authors.initials: H
authors.lastname: Iinuma
authors.forename: D
authors.initials: D
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D000192:Actinomycetales / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000900:Anti-Bacterial Agents