The discrepancy between the binding affinity of PTH (1-34) and RS 66271 is explained by interaction of the PTH/PTHrP receptor with G-protein.
Hoare
S R
SR
Usdin
T B
TB
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000378:metabolism / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D010281:Parathyroid Hormone / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation; D018016:Receptors, Parathyroid Hormone / Q000819:agonists / Q000378:metabolism*; D013329:Structure-Activity Relationship; D019379:Teriparatide / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D046911:Macromolecular Substances; D010281:Parathyroid Hormone; D010446:Peptide Fragments; D018016:Receptors, Parathyroid Hormone; D019379:Teriparatide; D016244:Guanosine 5'-O-(3-Thiotriphosphate); C104917:RS 66271; C025497:parathyroid hormone (3-34) amide, Nle(8,18)-Nle(34)-; D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins