title: Recombination in telomere-length maintenance.
abstract: Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion. Understanding the role that telomeric recombination might play in mammalian cells has important implications for cancer therapeutics.
authors.affiliation: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. kasseisl@cshl.org
authors.forename: A
authors.initials: A
authors.lastname: Kass-Eisler
authors.forename: C W
authors.initials: CW
authors.lastname: Greider
mesh_terms: D000818:Animals; D006801:Humans; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics; D019098:Telomerase / Q000378:metabolism; D016615:Telomere
chemical_list: D019098:Telomerase