title: Daily exercise attenuates the development of arterial blood pressure related cardiovascular risk factors in hypertensive rats.
abstract: This study was designed to test the hypothesis that daily spontaneous running (DSR) attenuates the development of blood pressure-related cardiovascular disease risk factors (BP-related CVD risk factors) in spontaneously hypertensive rats (SHR). After 8 weeks of DSR or sedentary control, rats were chronically instrumented with arterial catheters. Daily exercise attenuated the development of all measures of BP-related CVD risk factors. Specifically DSR attenuated the increase in systolic blood pressure (delta--22 mmHg), systolic blood pressure variability (delta--2.5 mmHg), and systolic blood pressure load (delta--27%). Similarly, DSR attenuated the increase in diastolic blood pressure (delta--15 mmHg), diastolic blood pressure variability (delta--1.19 mmHg), and diastolic blood pressure load (delta--17%). Finally, DSR attenuated the development of tachycardia (delta--63 bpm). These data demonstrate that daily exercise attenuates the development of hypertension and tachycardia in animals predisposed to hypertension.
authors.affiliation: Department of Physiology, Wayne State University School of Medicine Detroit, MI 48201, USA.
authors.forename: H L
authors.initials: HL
authors.lastname: Collins
authors.forename: D W
authors.initials: DW
authors.lastname: Rodenbaugh
authors.forename: S E
authors.initials: SE
authors.lastname: DiCarlo
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control*; D002940:Circadian Rhythm; D005260:Female; D006339:Heart Rate; D006973:Hypertension / Q000150:complications / Q000517:prevention & control*; D010805:Physical Conditioning, Animal; D051381:Rats; D011918:Rats, Inbred SHR; D012307:Risk Factors