Analysis of BDNF production in the aging gerbil cochlea.
Degeneration of cochlear neurons is the most commonly observed cellular change in the aging human and gerbil cochlea. Although it is unclear what leads to this neuronal loss, changes in the production of target-derived trophic factors may be the ultimate cause of cochlear neuron degeneration. The present study used an enzyme-linked immunosorbent assay to investigate whether BDNF is produced by the organ of Corti or cochlear ganglia of young, middle aged, or aged gerbils. The results revealed an age-related increase in BDNF in the organ of Corti, but not in the cochlear ganglia.
Medd
A M
AM
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Bianchi
L M
LM
D000375:Aging / Q000378:metabolism*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis / Q000096:biosynthesis*; D003051:Cochlea / Q000737:chemistry / Q000378:metabolism*; D004247:DNA / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005849:Gerbillinae; D009925:Organ of Corti / Q000737:chemistry; D013136:Spiral Ganglion / Q000737:chemistry
D019208:Brain-Derived Neurotrophic Factor; D004247:DNA