title: Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel mu opioid receptor ligands.
abstract: 3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1. The compounds exhibit high affinity for the mu opioid receptor.
authors.affiliation: CNS Discovery, Central Research Division, Pfizer Inc, Groton, CT 06340, USA.
authors.forename: M P
authors.initials: MP
authors.lastname: Allen
authors.forename: J F
authors.initials: JF
authors.lastname: Blake
authors.forename: D K
authors.initials: DK
authors.lastname: Bryce
authors.forename: M E
authors.initials: ME
authors.lastname: Haggan
authors.forename: S
authors.initials: S
authors.lastname: Liras
authors.forename: S
authors.initials: S
authors.lastname: McLean
authors.forename: B E
authors.initials: BE
authors.lastname: Segelstein
mesh_terms: D000818:Animals; D001596:Benzylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D001923:Brain Chemistry; D016466:CHO Cells; D006224:Cricetinae; D018360:Crystallography, X-Ray; D015195:Drug Design; D006801:Humans; D008024:Ligands; D015282:Octreotide / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017450:Receptors, Opioid, mu / Q000187:drug effects*
chemical_list: D001596:Benzylamines; D008024:Ligands; D017450:Receptors, Opioid, mu; C045210:3-Tyr-octreotide; D015282:Octreotide