title: The value of apolipoprotein E knockout mice for studying the effects of dietary fat and cholesterol on atherogenesis.
abstract: The ability of the apolipoprotein E-deficient mouse to develop spontaneous atherosclerosis, which resembles the human process, is an excellent model in which to assess the impact of dietary factors. This review discusses the role of several nutrients in the development of atherosclerosis and the mechanisms through which they act.
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Spain. Josada@posta.unizar.es
authors.forename: J
authors.initials: J
authors.lastname: Osada
authors.forename: J
authors.initials: J
authors.lastname: Joven
authors.forename: N
authors.initials: N
authors.lastname: Maeda
mesh_terms: D000818:Animals; D001057:Apolipoproteins E / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D001161:Arteriosclerosis / Q000209:etiology*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D051379:Mice; D018345:Mice, Knockout
chemical_list: D001057:Apolipoproteins E; D002791:Cholesterol, Dietary; D004041:Dietary Fats; D008074:Lipoproteins