Capillary electrophoresis as a versatile tool for the bioanalysis of drugs--a review.
This review article presents an overview of current research on the use of capillary electrophoretic techniques for the analysis of drugs in biological matrices. The principles of capillary electrophoresis and its various separation and detection modes are briefly discussed. Sample pretreatment methods which have been used for clean-up and concentration are discussed. Finally, an extensive overview of bioanalytical applications is presented. The bioanalyses of more than 200 drugs have been summarised, including the applied sample pretreatment methods and the achieved detection limits.
Boone
C M
CM
Department of Analytical Chemistry and Toxicology, University Center for Pharmacy, Groningen, The Netherlands. c.boone@farm.rug.nl
Waterval
J C
JC
Lingeman
H
H
Ensing
K
K
Underberg
W J
WJ
D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*
D004364:Pharmaceutical Preparations