title: A histopathological study of esophageal atresia and tracheoesophageal fistula.
abstract: OBJECTIVE
  Histopathologic examination of the esophagus has not been reported often in esophageal atresia (EA) and tracheoesophageal fistula (TEF). Abnormal esophageal motility has been reported after successful repair of EA and TEF, although the exact etiology of this motility disorder remains unclear. Histological evaluation of the fistulous portion of the esophagus has been performed to document any abnormality that may be responsible for the abnormal motility.
  
  
  METHODS
  Histopathological study of fistulous segment of esophageal atresia and distal TEF was conducted on 65 patients, which included autopsy material from 3 patients in whom the entire esophagus was examined by serial section. Special stains were administered to each specimen to look for tracheobronchial remnants and the arrangement of muscle fibers. Clinical evaluation was performed in 27 patients who were available for review 6 months to 9 years after successful surgical treatment. These patients were categorized into 3 groups according to their clinical status.
  
  
  RESULTS
  These findings showed that the majority of these patients have tracheobronchial remnants in the esophagus in the form of abnormal mucous glands and ducts, abnormal mucin secretion, presence of cartilage, and a disorganized muscle coat.
  
  
  CONCLUSIONS
  The presence of abnormal mucous glands and abnormal mucin secretion has not been highlighted before. Although tracheobronchial remnants and a disorganized muscle coat are common findings in the fistulous portion of the esophagus, these may not reflect the structure of the remaining esophagus.
authors.affiliation: Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi.
authors.forename: H K
authors.initials: HK
authors.lastname: Dutta
authors.forename: M
authors.initials: M
authors.lastname: Mathur
authors.forename: V
authors.initials: V
authors.lastname: Bhatnagar
mesh_terms: D001706:Biopsy; D004933:Esophageal Atresia / Q000473:pathology* / Q000601:surgery; D004947:Esophagus / Q000002:abnormalities / Q000473:pathology*; D006801:Humans; D014138:Tracheoesophageal Fistula / Q000473:pathology* / Q000601:surgery