Adult offspring long-term effects of high salt and water intake during pregnancy.
Offspring from dams subjected to hypereninemia, hyperdipsia, and natriophilia by partial aortic ligation (PAL) showed a long-term modification of their ingestive behavior. These rats, upon reaching adulthood, showed an increased appetite for low-concentration saline solutions (0.1 M) when compared to control rats. They also presented a high intake of a medium concentration NaCl solution (0.45 M) after having been offered a very aversive highly concentrated NaCl solution (1.0 M) along with water for 2 days. An increase was also observed in their salt/water intake ratio following two different thirst challenges, 24-h fluid deprivation or sodium depletion by furosemide treatment. The demonstration of the long-term effect of pregnancy history on salt preference in adult offspring draws attention to the possible physiopathological aspects that may be of relevance, considering the well-established relationship between salt intake and hypertension, a disease most commonly occurring in the adult and aged population.
Argüelles
J
J
Area de Fisiología, Departamento de Biología Funcional, Facultad de Medicina, c/ Julián Clavería s/n, Oviedo, Asturias, 33006, Spain.
Brime
J I
JI
López-Sela
P
P
Perillán
C
C
Vijande
M
M
D000367:Age Factors; D000809:Angiotensins / Q000502:physiology; D000818:Animals; D001011:Aorta / Q000601:surgery; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001362:Avoidance Learning / Q000502:physiology; D004326:Drinking; D004327:Drinking Behavior / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007774:Lactation; D008026:Ligation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*; D013894:Thirst / Q000187:drug effects / Q000502:physiology; D014868:Water Deprivation
D000809:Angiotensins; D017673:Sodium Chloride, Dietary