Salient features and HLA markers of childhood psoriasis in Kuwait.
A total of 305 consecutive Kuwaiti children with psoriasis were studied for clinical features and 50 children were tissue typed for HLA class I and class II antigens. The salient features of psoriasis in these children included: female preponderance (M : F ratio, 1:1.5); peak age of onset between 2 and 8 years; scalp as the most common site of onset (30%); scalp and extensors of legs as commonly affected sites (52.5% each); plaque psoriasis the most common clinical type (89%); and a positive family history of psoriasis in 34% of the patients. Kuwaiti children with psoriasis showed a significant association with HLA-A3, Cw1, and DR7 antigens and those with a positive family history of psoriasis had a significant association with HLA-DR8 antigen.
Nanda
A
A
Asad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait.
Al-Fouzan
A S
AS
El-Kashlan
M
M
Al-Sweih
N
N
Al-Muzairai
I
I
D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006650:Histocompatibility Testing; D006801:Humans; D007223:Infant; D007730:Kuwait; D008297:Male; D011565:Psoriasis / Q000235:genetics / Q000276:immunology* / Q000473:pathology
D015415:Biomarkers; D006680:HLA Antigens