title: From sequence to chromosome: the tip of the X chromosome of D. melanogaster.
abstract: One of the rewards of having a Drosophila melanogaster whole-genome sequence will be the potential to understand the molecular bases for structural features of chromosomes that have been a long-standing puzzle. Analysis of 2.6 megabases of sequence from the tip of the X chromosome of Drosophila identifies 273 genes. Cloned DNAs from the characteristic bulbous structure at the tip of the X chromosome in the region of the broad complex display an unusual pattern of in situ hybridization. Sequence analysis revealed that this region comprises 154 kilobases of DNA flanked by 1.2-kilobases of inverted repeats, each composed of a 350-base pair satellite related element. Thus, some aspects of chromosome structure appear to be revealed directly within the DNA sequence itself.
authors.affiliation: The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton Hall, Cambridge CB10 1SD, UK.
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mesh_terms: D000818:Animals; D002871:Chromosome Banding; D019295:Computational Biology; D003360:Cosmids; D004251:DNA Transposable Elements; D004276:DNA, Satellite; D004331:Drosophila melanogaster / Q000235:genetics*; D017344:Genes, Insect; D017403:In Situ Hybridization; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA; D014960:X Chromosome / Q000235:genetics* / Q000648:ultrastructure
chemical_list: D004251:DNA Transposable Elements; D004276:DNA, Satellite