Mood stabilizer augmentation with olanzapine in acutely manic children.
We report on three cases of acutely manic prepubertal children diagnosed with bipolar disorder who were treated with olanzapine in addition to their existing mood stabilizer regimens. All three had marked improvement of their manic symptoms within 3-5 days of beginning olanzapine therapy as measured by clinician-rated instruments. Adverse effects included sedation and weight gain. These results suggest that olanzapine may have an antimanic or mood stabilizing effect in acutely manic children with bipolar disorder.
Chang
K D
KD
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305-5540, USA. kchang88@leland.stanford.edu
Ketter
T A
TA
D018692:Antimanic Agents / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001289:Attention Deficit Disorder with Hyperactivity; D001569:Benzodiazepines; D001714:Bipolar Disorder / Q000188:drug therapy*; D002648:Child; D004359:Drug Therapy, Combination; D006801:Humans; D018021:Lithium Chloride / Q000627:therapeutic use; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D012894:Sleep Stages / Q000187:drug effects; D014635:Valproic Acid / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects
D018692:Antimanic Agents; D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D014635:Valproic Acid; D018021:Lithium Chloride; D000077152:Olanzapine