title: The genome sequence of Drosophila melanogaster.
abstract: The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
authors.affiliation: Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Adams
authors.forename: S E
authors.initials: SE
authors.lastname: Celniker
authors.forename: R A
authors.initials: RA
authors.lastname: Holt
authors.forename: C A
authors.initials: CA
authors.lastname: Evans
authors.forename: J D
authors.initials: JD
authors.lastname: Gocayne
authors.forename: P G
authors.initials: PG
authors.lastname: Amanatides
authors.forename: S E
authors.initials: SE
authors.lastname: Scherer
authors.forename: P W
authors.initials: PW
authors.lastname: Li
authors.forename: R A
authors.initials: RA
authors.lastname: Hoskins
authors.forename: R F
authors.initials: RF
authors.lastname: Galle
authors.forename: R A
authors.initials: RA
authors.lastname: George
authors.forename: S E
authors.initials: SE
authors.lastname: Lewis
authors.forename: S
authors.initials: S
authors.lastname: Richards
authors.forename: M
authors.initials: M
authors.lastname: Ashburner
authors.forename: S N
authors.initials: SN
authors.lastname: Henderson
authors.forename: G G
authors.initials: GG
authors.lastname: Sutton
authors.forename: J R
authors.initials: JR
authors.lastname: Wortman
authors.forename: M D
authors.initials: MD
authors.lastname: Yandell
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: L X
authors.initials: LX
authors.lastname: Chen
authors.forename: R C
authors.initials: RC
authors.lastname: Brandon
authors.forename: Y H
authors.initials: YH
authors.lastname: Rogers
authors.forename: R G
authors.initials: RG
authors.lastname: Blazej
authors.forename: M
authors.initials: M
authors.lastname: Champe
authors.forename: B D
authors.initials: BD
authors.lastname: Pfeiffer
authors.forename: K H
authors.initials: KH
authors.lastname: Wan
authors.forename: C
authors.initials: C
authors.lastname: Doyle
authors.forename: E G
authors.initials: EG
authors.lastname: Baxter
authors.forename: G
authors.initials: G
authors.lastname: Helt
authors.forename: C R
authors.initials: CR
authors.lastname: Nelson
authors.forename: G L
authors.initials: GL
authors.lastname: Gabor
authors.forename: J F
authors.initials: JF
authors.lastname: Abril
authors.forename: A
authors.initials: A
authors.lastname: Agbayani
authors.forename: H J
authors.initials: HJ
authors.lastname: An
authors.forename: C
authors.initials: C
authors.lastname: Andrews-Pfannkoch
authors.forename: D
authors.initials: D
authors.lastname: Baldwin
authors.forename: R M
authors.initials: RM
authors.lastname: Ballew
authors.forename: A
authors.initials: A
authors.lastname: Basu
authors.forename: J
authors.initials: J
authors.lastname: Baxendale
authors.forename: L
authors.initials: L
authors.lastname: Bayraktaroglu
authors.forename: E M
authors.initials: EM
authors.lastname: Beasley
authors.forename: K Y
authors.initials: KY
authors.lastname: Beeson
authors.forename: P V
authors.initials: PV
authors.lastname: Benos
authors.forename: B P
authors.initials: BP
authors.lastname: Berman
authors.forename: D
authors.initials: D
authors.lastname: Bhandari
authors.forename: S
authors.initials: S
authors.lastname: Bolshakov
authors.forename: D
authors.initials: D
authors.lastname: Borkova
authors.forename: M R
authors.initials: MR
authors.lastname: Botchan
authors.forename: J
authors.initials: J
authors.lastname: Bouck
authors.forename: P
authors.initials: P
authors.lastname: Brokstein
authors.forename: P
authors.initials: P
authors.lastname: Brottier
authors.forename: K C
authors.initials: KC
authors.lastname: Burtis
authors.forename: D A
authors.initials: DA
authors.lastname: Busam
authors.forename: H
authors.initials: H
authors.lastname: Butler
authors.forename: E
authors.initials: E
authors.lastname: Cadieu
authors.forename: A
authors.initials: A
authors.lastname: Center
authors.forename: I
authors.initials: I
authors.lastname: Chandra
authors.forename: J M
authors.initials: JM
authors.lastname: Cherry
authors.forename: S
authors.initials: S
authors.lastname: Cawley
authors.forename: C
authors.initials: C
authors.lastname: Dahlke
authors.forename: L B
authors.initials: LB
authors.lastname: Davenport
authors.forename: P
authors.initials: P
authors.lastname: Davies
authors.forename: B
authors.initials: B
authors.lastname: de Pablos
authors.forename: A
authors.initials: A
authors.lastname: Delcher
authors.forename: Z
authors.initials: Z
authors.lastname: Deng
authors.forename: A D
authors.initials: AD
authors.lastname: Mays
authors.forename: I
authors.initials: I
authors.lastname: Dew
authors.forename: S M
authors.initials: SM
authors.lastname: Dietz
authors.forename: K
authors.initials: K
authors.lastname: Dodson
authors.forename: L E
authors.initials: LE
authors.lastname: Doup
authors.forename: M
authors.initials: M
authors.lastname: Downes
authors.forename: S
authors.initials: S
authors.lastname: Dugan-Rocha
authors.forename: B C
authors.initials: BC
authors.lastname: Dunkov
authors.forename: P
authors.initials: P
authors.lastname: Dunn
authors.forename: K J
authors.initials: KJ
authors.lastname: Durbin
authors.forename: C C
authors.initials: CC
authors.lastname: Evangelista
authors.forename: C
authors.initials: C
authors.lastname: Ferraz
authors.forename: S
authors.initials: S
authors.lastname: Ferriera
authors.forename: W
authors.initials: W
authors.lastname: Fleischmann
authors.forename: C
authors.initials: C
authors.lastname: Fosler
authors.forename: A E
authors.initials: AE
authors.lastname: Gabrielian
authors.forename: N S
authors.initials: NS
authors.lastname: Garg
authors.forename: W M
authors.initials: WM
authors.lastname: Gelbart
authors.forename: K
authors.initials: K
authors.lastname: Glasser
authors.forename: A
authors.initials: A
authors.lastname: Glodek
authors.forename: F
authors.initials: F
authors.lastname: Gong
authors.forename: J H
authors.initials: JH
authors.lastname: Gorrell
authors.forename: Z
authors.initials: Z
authors.lastname: Gu
authors.forename: P
authors.initials: P
authors.lastname: Guan
authors.forename: M
authors.initials: M
authors.lastname: Harris
authors.forename: N L
authors.initials: NL
authors.lastname: Harris
authors.forename: D
authors.initials: D
authors.lastname: Harvey
authors.forename: T J
authors.initials: TJ
authors.lastname: Heiman
authors.forename: J R
authors.initials: JR
authors.lastname: Hernandez
authors.forename: J
authors.initials: J
authors.lastname: Houck
authors.forename: D
authors.initials: D
authors.lastname: Hostin
authors.forename: K A
authors.initials: KA
authors.lastname: Houston
authors.forename: T J
authors.initials: TJ
authors.lastname: Howland
authors.forename: M H
authors.initials: MH
authors.lastname: Wei
authors.forename: C
authors.initials: C
authors.lastname: Ibegwam
authors.forename: M
authors.initials: M
authors.lastname: Jalali
authors.forename: F
authors.initials: F
authors.lastname: Kalush
authors.forename: G H
authors.initials: GH
authors.lastname: Karpen
authors.forename: Z
authors.initials: Z
authors.lastname: Ke
authors.forename: J A
authors.initials: JA
authors.lastname: Kennison
authors.forename: K A
authors.initials: KA
authors.lastname: Ketchum
authors.forename: B E
authors.initials: BE
authors.lastname: Kimmel
authors.forename: C D
authors.initials: CD
authors.lastname: Kodira
authors.forename: C
authors.initials: C
authors.lastname: Kraft
authors.forename: S
authors.initials: S
authors.lastname: Kravitz
authors.forename: D
authors.initials: D
authors.lastname: Kulp
authors.forename: Z
authors.initials: Z
authors.lastname: Lai
authors.forename: P
authors.initials: P
authors.lastname: Lasko
authors.forename: Y
authors.initials: Y
authors.lastname: Lei
authors.forename: A A
authors.initials: AA
authors.lastname: Levitsky
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Mattei
authors.forename: T C
authors.initials: TC
authors.lastname: McIntosh
authors.forename: M P
authors.initials: MP
authors.lastname: McLeod
authors.forename: D
authors.initials: D
authors.lastname: McPherson
authors.forename: G
authors.initials: G
authors.lastname: Merkulov
authors.forename: N V
authors.initials: NV
authors.lastname: Milshina
authors.forename: C
authors.initials: C
authors.lastname: Mobarry
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Moshrefi
authors.forename: S M
authors.initials: SM
authors.lastname: Mount
authors.forename: M
authors.initials: M
authors.lastname: Moy
authors.forename: B
authors.initials: B
authors.lastname: Murphy
authors.forename: L
authors.initials: L
authors.lastname: Murphy
authors.forename: D M
authors.initials: DM
authors.lastname: Muzny
authors.forename: D L
authors.initials: DL
authors.lastname: Nelson
authors.forename: D R
authors.initials: DR
authors.lastname: Nelson
authors.forename: K A
authors.initials: KA
authors.lastname: Nelson
authors.forename: K
authors.initials: K
authors.lastname: Nixon
authors.forename: D R
authors.initials: DR
authors.lastname: Nusskern
authors.forename: J M
authors.initials: JM
authors.lastname: Pacleb
authors.forename: M
authors.initials: M
authors.lastname: Palazzolo
authors.forename: G S
authors.initials: GS
authors.lastname: Pittman
authors.forename: S
authors.initials: S
authors.lastname: Pan
authors.forename: J
authors.initials: J
authors.lastname: Pollard
authors.forename: V
authors.initials: V
authors.lastname: Puri
authors.forename: M G
authors.initials: MG
authors.lastname: Reese
authors.forename: K
authors.initials: K
authors.lastname: Reinert
authors.forename: K
authors.initials: K
authors.lastname: Remington
authors.forename: R D
authors.initials: RD
authors.lastname: Saunders
authors.forename: F
authors.initials: F
authors.lastname: Scheeler
authors.forename: H
authors.initials: H
authors.lastname: Shen
authors.forename: B C
authors.initials: BC
authors.lastname: Shue
authors.forename: I
authors.initials: I
authors.lastname: Sidén-Kiamos
authors.forename: M
authors.initials: M
authors.lastname: Simpson
authors.forename: M P
authors.initials: MP
authors.lastname: Skupski
authors.forename: T
authors.initials: T
authors.lastname: Smith
authors.forename: E
authors.initials: E
authors.lastname: Spier
authors.forename: A C
authors.initials: AC
authors.lastname: Spradling
authors.forename: M
authors.initials: M
authors.lastname: Stapleton
authors.forename: R
authors.initials: R
authors.lastname: Strong
authors.forename: E
authors.initials: E
authors.lastname: Sun
authors.forename: R
authors.initials: R
authors.lastname: Svirskas
authors.forename: C
authors.initials: C
authors.lastname: Tector
authors.forename: R
authors.initials: R
authors.lastname: Turner
authors.forename: E
authors.initials: E
authors.lastname: Venter
authors.forename: A H
authors.initials: AH
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Wang
authors.forename: D A
authors.initials: DA
authors.lastname: Wassarman
authors.forename: G M
authors.initials: GM
authors.lastname: Weinstock
authors.forename: J
authors.initials: J
authors.lastname: Weissenbach
authors.forename: S M
authors.initials: SM
authors.lastname: Williams
authors.lastname: WoodageT
authors.forename: K C
authors.initials: KC
authors.lastname: Worley
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: Q A
authors.initials: QA
authors.lastname: Yao
authors.forename: J
authors.initials: J
authors.lastname: Ye
authors.forename: R F
authors.initials: RF
authors.lastname: Yeh
authors.forename: J S
authors.initials: JS
authors.lastname: Zaveri
authors.forename: M
authors.initials: M
authors.lastname: Zhan
authors.forename: G
authors.initials: G
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.forename: X H
authors.initials: XH
authors.lastname: Zheng
authors.forename: F N
authors.initials: FN
authors.lastname: Zhong
authors.forename: W
authors.initials: W
authors.lastname: Zhong
authors.forename: X
authors.initials: X
authors.lastname: Zhou
authors.forename: S
authors.initials: S
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: H O
authors.initials: HO
authors.lastname: Smith
authors.forename: R A
authors.initials: RA
authors.lastname: Gibbs
authors.forename: E W
authors.initials: EW
authors.lastname: Myers
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
authors.forename: J C
authors.initials: JC
authors.lastname: Venter
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000235:genetics; D002843:Chromatin / Q000235:genetics; D003001:Cloning, Molecular; D019295:Computational Biology; D020451:Contig Mapping; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004261:DNA Replication / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics* / Q000378:metabolism; D022041:Euchromatin; D015723:Gene Library; D017344:Genes, Insect; D016678:Genome; D006570:Heterochromatin / Q000235:genetics; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics; D014176:Protein Biosynthesis; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D022041:Euchromatin; D006570:Heterochromatin; D019476:Insect Proteins; D009687:Nuclear Proteins; D003577:Cytochrome P-450 Enzyme System