Investigation on the formation of the hormone reception mechanism.
The formation of the hormone receptor mechanism is part of the embryonic development. The perinatal age seems to be critical for the maturation of this system, i.e. the development of the proper hormone selectivity, the number of the receptors, their sensitivity to the adequate hormone. Our team tried to get a closer view on this developmental period examining different parameters in different model systems. We were able to show that during the maturation of the hormonal system similar responses could be elicited by the later specific hormones or by the non-specific ones but structurally similar compounds. Also it became evident that one single hormonal treatment, applied during in the perinatal age, could influence the responsiveness to hormones of the adult animals.
Dobozy
O
O
Department of Genetics, Cell- and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary.
Karabélyos
C
C
Pap
E
E
Kiss
A
A
D004622:Embryo, Mammalian / Q000187:drug effects*; D004625:Embryo, Nonmammalian; D006728:Hormones / Q000494:pharmacology*; D008115:Liver Regeneration / Q000187:drug effects*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D006728:Hormones; D011956:Receptors, Cell Surface