title: Bioactive saponins and glycosides. XV. Saponin constituents with gastroprotective effect from the seeds of tea plant, Camellia sinensis L. var. assamica Pierre, cultivated in Sri Lanka: structures of assamsaponins A, B, C, D, and E.
abstract: The saponin fraction from the seeds of the tea plant, Camellia sinensis L. var. assamica Pierre cultivated in Sri Lanka, was found to show a potent protective effect on gastric mucosal lesions induced by ethanol in rats. Nine new acylated polyhydroxyoleanene-type triterpene oligoglycosides called assamsaponins A-I were isolated from the active saponin fraction together with three known saponins, theasaponin E1 and E2 and camelliasaponin B1. The structures of assamsaponins A-E were elucidated on the basis of chemical and physicochemical evidence. Theasaponin E1 exhibited potent gastroprotective activity.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002240:Carbohydrate Sequence; D002492:Central Nervous System Depressants / Q000633:toxicity; D020448:Ericales / Q000737:chemistry*; D000431:Ethanol / Q000633:toxicity; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D051381:Rats; D012503:Saponins / Q000138:chemical synthesis* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013188:Sri Lanka; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D012503:Saponins; D000431:Ethanol