Pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation.
A series of pyrrolo[3,2-c]pyridines, isosteres of the antithrombotic drug ticlopidine, has been synthesized and evaluated in vitro for the ability to inhibit aggregation of human platelet-rich plasma induced by adenosin 5'-diphosphate (ADP). Structure-activity relationships showed their antiplatelet effects to be related to the lipophilicity.
Altomare
C
C
Dipartimento Farmacochimico, Università degli Studi, Bari, Italy. altomare@farmchim.uniba.it
Summo
L
L
Cellamare
S
S
Varlamov
A V
AV
Voskressensky
L G
LG
Borisova
T N
TN
Carotti
A
A
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013988:Ticlopidine / Q000494:pharmacology
D008055:Lipids; D010975:Platelet Aggregation Inhibitors; D011725:Pyridines; D011758:Pyrroles; D000244:Adenosine Diphosphate; D013988:Ticlopidine