Primate models of AIDS.
The primate models of AIDS provide insights into pathogenesis, transmission, and immune responses to infection and are useful in testing vaccines and drugs. The HIV-1/chimpanzee, SIV(mac)/macaque, and SHIV/macaque models are the most widely used. The advantages and drawbacks of these and other models are discussed.
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JODI Research Inc., Wexford, Pennsylvania and the Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas School of Medicine, Kansas, City, Kansas, USA.
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology; D000818:Animals; D004195:Disease Models, Animal; D015497:HIV-1 / Q000235:genetics; D015498:HIV-2 / Q000235:genetics; D006801:Humans; D008251:Macaca; D002679:Pan troglodytes; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics