title: [The assessment of the treatment of viral hepatitis C with interferon alpha in children with leukemias and lymphomas].
abstract: Interferon alfa in dose 3-6 MU IM was administered during six months 3 times per week in 30 children with chronic hepatitis C with leukaemias and lymphomas. Chronic hepatitis was diagnosed basing on anti-HCV, RNA HCV by PCR, high activity of ALT and histopathologic examination of the liver. The patients were followed-up for 12 months after IFN therapy. Sustained normalization of ALT levels, together with serum HCV RNA elimination was considered as a complete response and achieved in 33% children. Partial response (ALT normalization without serum HCV RNA elimination) was recorded in 57% patients. Anti HCV antibody was detected in all children during the time of observation.
authors.affiliation: Katedry i Kliniki Pediatrii Hematologii i Onkologii Akademii Medycznej w Warszawie.
authors.forename: K
authors.initials: K
authors.lastname: Pawelec
authors.forename: B
authors.initials: B
authors.lastname: Zielecka-Walewska
authors.forename: E
authors.initials: E
authors.lastname: Brojer
authors.forename: R
authors.initials: R
authors.lastname: Rokicka-Milewska
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006508:Hepatitis Antibodies / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007938:Leukemia / Q000150:complications*; D008223:Lymphoma / Q000150:complications*; D008297:Male
chemical_list: D000998:Antiviral Agents; D006508:Hepatitis Antibodies; D016898:Interferon-alpha