Parallel synthesis of a series of subtype-selective NMDA receptor antagonists.
A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for the NR1A/2B receptor subtype.
Gregory
T F
TF
Department of Chemistry, Parke-Davis Pharmaceutical Research, Ann Arbor, MI 48105, USA. tracy.gregory@wl.com
Wright
J L
JL
Wise
L D
LD
Meltzer
L T
LT
Serpa
K A
KA
Konkoy
C S
CS
Whittemore
E R
ER
Woodward
R M
RM
D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D016627:Oxidopamine; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013563:Sympathectomy, Chemical; D013565:Sympatholytics
D018691:Excitatory Amino Acid Antagonists; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; D013565:Sympatholytics; D016627:Oxidopamine