Human lens effect on in vivo scanning laser polarimetric measurements of retinal nerve fiber layer thickness.
OBJECTIVE
To determine the effect of the human lens on retinal nerve fiber layer measurements by scanning laser polarimetry. This technique uses the form birefringence of the retinal nerve fiber layer to estimate its thickness. The GDx Nerve Fiber Analyzer contains an optical retarder element to compensate for the birefringence of the human cornea.


METHODS
Fourteen nonglaucomatous pseudophakic or aphakic eyes were matched by age and race to 14 nonglaucomatous phakic eyes. Intraocular pressure, optic nerve head evaluation by slit lamp biomicroscopy and visual fields were performed to establish the absence of glaucoma. The nerve fiber layer thickness measurements by the GDx Nerve Fiber Analyzer were compared between the two groups.


RESULTS
The average nerve fiber layer thickness in the phakic group was 67.2+/-11.9 ,m and in the nonphakic group was 66.1 +/- 11.8 microm (P=0.80).


CONCLUSIONS
The human lens has negligible influence on in vivo nerve fiber layer thickness measured by the GDx Nerve Fiber Analyzer.
Collur
S
S
New York University Medical Center, New York, USA.
Carroll
A M
AM
Cameron
B D
BD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001036:Aphakia, Postcataract / Q000150:complications; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D007834:Lasers; D007908:Lens, Crystalline / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D009900:Optic Nerve / Q000033:anatomy & histology*; D011446:Prospective Studies; D019591:Pseudophakia / Q000150:complications; D012160:Retina / Q000033:anatomy & histology*