title: Outcome of meningitis caused by Streptococcus pneumoniae and Haemophilus influenzae type b in children in The Gambia.
abstract: In developing countries, endemic childhood meningitis is a severe disease caused most commonly by Streptococcus pneumoniae or Haemophilus influenzae type b (Hib). Although many studies have shown that fatality rates associated with meningitis caused by these organisms are high in developing countries, little is known about the long-term outcome of survivors. The purpose of this study was to assess the importance of disabilities following pneumococcal and Hib meningitis in The Gambia. 257 children aged 0-12 years hospitalized between 1990 and 1995 with culture-proven S. pneumoniae (n = 134) or Hib (n = 123) meningitis were included retrospectively in the study. 48% of children with pneumococcal meningitis and 27% of children with Hib meningitis died whilst in hospital. Of the 160 survivors, 89 (55%) were followed up between September 1996 and October 1997. Of the children with pneumococcal meningitis that were traced, 58% had clinical sequelae; half of them had major disabilities preventing normal adaptation to social life. 38% of survivors of Hib meningitis had clinical sequelae, a quarter of whom had major disabilities. Major handicaps found were hearing loss, mental retardation, motor abnormalities and seizures. These data show that despite treatment with effective antibiotics, pneumococcal and Hib meningitis kill many Gambian children and leave many survivors with severe sequelae. Hib vaccination is now given routinely in The Gambia; an effective pneumococcal vaccine is needed.
authors.affiliation: Medical Research Council Laboratories, Fajara, The Gambia.
authors.forename: T
authors.initials: T
authors.lastname: Goetghebuer
authors.forename: T E
authors.initials: TE
authors.lastname: West
authors.forename: V
authors.initials: V
authors.lastname: Wermenbol
authors.forename: A L
authors.initials: AL
authors.lastname: Cadbury
authors.forename: P
authors.initials: P
authors.lastname: Milligan
authors.forename: N
authors.initials: N
authors.lastname: Lloyd-Evans
authors.forename: R A
authors.initials: RA
authors.lastname: Adegbola
authors.forename: E K
authors.initials: EK
authors.lastname: Mulholland
authors.forename: B M
authors.initials: BM
authors.lastname: Greenwood
authors.forename: M W
authors.initials: MW
authors.lastname: Weber
mesh_terms: D002648:Child; D002675:Child, Preschool; D003638:Deafness / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005714:Gambia / Q000453:epidemiology; D019741:Haemophilus influenzae type b; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D008583:Meningitis, Haemophilus / Q000150:complications* / Q000453:epidemiology / Q000401:mortality*; D008586:Meningitis, Pneumococcal / Q000150:complications* / Q000453:epidemiology / Q000401:mortality*; D009048:Motor Skills; D012008:Recurrence; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology