title: [Ultrasound elastography of the prostate. A new technique for tumor detection].
abstract: OBJECTIVE
  Prostate tumours are often of harder consistency than the surrounding tissue. During digital rectal examination, this fact can be used not only to detect hypertrophy but also localized hardenings. The examination by digital palpation is inaccurate and, even in combination with PSA-value and a transrectal ultrasonic examination, the result is often not reliable. Ultrasound elastography enables us to measure and visualize the elastic properties of a tissue region and is a useful supplement to the examination by digital palpation. Ultrasound elastography is able to measure and visualize the elastic properties of a tissue region, therefore it is a useful supplement to commonly used diagnostic procedures.
  
  
  METHODS
  We have developed a new system for elastographic prostate diagnosis which can be used during the transrectal ultrasonic examination. During the examination a sequence of ultrasonic images is acquired while the organ is slightly compressed by the ultrasound probe. Using numerical analysis of image pairs for the acquired sequence we calculate the tissue strain which represents the spatial elasticity distribution of a specific cross-section of the organ. This enables us to distinguish hard areas in the tissue. Image artifacts resulting from lateral motion components, i.e., orthogonal to the direction of the applied force, are compensated for by a special approach.
  
  
  RESULTS
  We present results obtained from a typical elastography phantom and also the first in vivo images from patients who were undergoing radical prostatectomy. Our images prove that ultrasound elastography has the potential to detect malignant tissue areas, which are inconspicuous in the B-mode image. Our findings are confirmed by the corresponding histological specimens.
authors.affiliation: Institut für Hochfrequenztechnik, Ruhr-Universität Bochum. lorenz@lp-it.de
authors.forename: A
authors.initials: A
authors.lastname: Lorenz
authors.forename: H
authors.initials: H
authors.lastname: Ermert
authors.forename: H J
authors.initials: HJ
authors.lastname: Sommerfeld
authors.forename: M
authors.initials: M
authors.lastname: Garcia-Schürmann
authors.forename: T
authors.initials: T
authors.lastname: Senge
authors.forename: S
authors.initials: S
authors.lastname: Philippou
mesh_terms: D004548:Elasticity; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging*; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D015203:Reproducibility of Results; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods