title: Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP).
abstract: The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to alpha1-acid glycoprotein, is reported.
authors.affiliation: Department of Chemistry, The University, Newcastle upon Tyne, UK.
authors.forename: H C
authors.initials: HC
authors.lastname: Barlow
authors.forename: K J
authors.initials: KJ
authors.lastname: Bowman
authors.forename: N J
authors.initials: NJ
authors.lastname: Curtin
authors.forename: A H
authors.initials: AH
authors.lastname: Calvert
authors.forename: B T
authors.initials: BT
authors.lastname: Golding
authors.forename: B
authors.initials: B
authors.lastname: Huang
authors.forename: P J
authors.initials: PJ
authors.lastname: Loughlin
authors.forename: D R
authors.initials: DR
authors.lastname: Newell
authors.forename: P G
authors.initials: PG
authors.lastname: Smith
authors.forename: R J
authors.initials: RJ
authors.lastname: Griffin
mesh_terms: D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D009705:Nucleosides / Q000378:metabolism*; D009961:Orosomucoid / Q000378:metabolism*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D009705:Nucleosides; D009961:Orosomucoid; D011743:Pyrimidines