title: [Changes in the concentration of individual proteins in women using current peroral contraceptives].
abstract: BUT: The aim of the present study was to establish the influence of the moderate combined oral contraceptives on the concentration of the individual proteins in serum.
  
  
  METHODS
  The study included 70 women at the age from 16 to 30, separated into two groups: control group, including 30 women who have not used OC basic group, including 40 women using Cilest and Marvelon in the period of one to three years. There have been examined the following individual proteins in serum: prealbumin; orosomucoid; haptoglobin; TRA; C3; C4; CRP; IgA; IgG and IgM. Their level in serum was defined with immunoturbidimetric method with monoclonal antibodies of the firm Kone (Fin).
  
  
  RESULTS
  The data showed reduced concentrations of Orosomucoid and increased concentrations of TRA in the basic group.
  
  
  CONCLUSIONS
  The continuous use of Cilest and Marvelon do not influence the concentrations of the examined individual proteins in the serum. They lead to reduced concentrations of orosomucoid and increased concentrations of TRA.
authors.affiliation: Department of Obstetrics and Gynaecology, Higher Medical Institute, Plovdiv.
authors.forename: E
authors.initials: E
authors.lastname: Ulichkova
authors.forename: M
authors.initials: M
authors.lastname: Malinova
authors.forename: B
authors.initials: B
authors.lastname: Pekhlivanov
authors.forename: I
authors.initials: I
authors.lastname: Sirakova
mesh_terms: D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis* / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects; D017135:Desogestrel / Q000009:adverse effects; D004338:Drug Combinations; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D009644:Norgestrel / Q000031:analogs & derivatives
chemical_list: D001798:Blood Proteins; D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; C109079:norgestimate, ethinyl estradiol drug combination; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D017135:Desogestrel