title: Pooling of urine specimens for detection of asymptomatic Chlamydia trachomatis infections by PCR in a low-prevalence population: cost-saving strategy for epidemiological studies and screening programs.
abstract: Pooling, in groups of five, of urine specimens from asymptomatically infected men in a population with 4% prevalence, as determined by case finding, is 100% sensitive and specific and results in a 60.5% reduction in the number of tests needed. Pooling of urine specimens in groups of 10 for the estimation of population-based prevalence is 96.1% sensitive and 100% specific and saves 90% of the test costs.
authors.affiliation: Department of Pathology, Section of Molecular Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: S A
authors.initials: SA
authors.lastname: Morré
authors.forename: C J
authors.initials: CJ
authors.lastname: Meijer
authors.forename: C
authors.initials: C
authors.lastname: Munk
authors.forename: S
authors.initials: S
authors.lastname: Krüger-Kjaer
authors.forename: J F
authors.initials: JF
authors.lastname: Winther
authors.forename: H O
authors.initials: HO
authors.lastname: Jørgensens
authors.forename: A J
authors.initials: AJ
authors.lastname: van Den Brule
mesh_terms: D001437:Bacteriuria / Q000175:diagnosis / Q000382:microbiology; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000235:genetics / Q000302:isolation & purification*; D017046:Cost Savings; D006801:Humans; D008297:Male; D008403:Mass Screening; D016133:Polymerase Chain Reaction / Q000379:methods*; D015995:Prevalence; D012680:Sensitivity and Specificity; D014556:Urine / Q000382:microbiology*