Polyphosphate in bone.
Human bone-forming osteoblasts are an excellent model to investigate the multiple functions of inorganic polyphosphates (polyP) for the following reasons: 1) they contain relatively high amounts of polyP and polyP-dependent enzymes; 2) they allow the study of both general and specific functions of these polymers, and 3) medically relevant results can be expected from these studies.
Schröder
H C
HC
Institut für Physiologische Chemie, Universität, Mainz, D-55099, Germany. hschroed@mail.uni-mainz.de
Kurz
L
L
Müller
W E
WE
Lorenz
B
B
D017766:Acid Anhydride Hydrolases / Q000378:metabolism; D001847:Bone Diseases / Q000188:drug therapy / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D004164:Diphosphonates / Q000627:therapeutic use; D005544:Forecasting; D006801:Humans; D010006:Osteoblasts / Q000378:metabolism; D011122:Polyphosphates / Q000378:metabolism*
D004164:Diphosphonates; D011122:Polyphosphates; D017766:Acid Anhydride Hydrolases; C022563:endopolyphosphatase