title: Intra-arterial reteplase for the treatment of acute limb ischemia.
abstract: The removal of urokinase from the market has created a dilemma for interventionists and vascular surgeons treating patients with acute limb threatening ischemia due to arterial thrombosis or embolization. Reteplase is a newer, fibrin-specific thrombolytic agent with properties that make it an attractive alternative to urokinase. We report two cases of successful treatment of acute, limb threatening ischemia with intra-arterial Reteplase therapy.
authors.affiliation: Cardiovascular Research Foundation, 110 Irving Street N.W., Suite 4B-1, Washington, D.C. 20010, USA. jrl2@mhg.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Laird
authors.forename: G
authors.initials: G
authors.lastname: Dangas
authors.forename: M
authors.initials: M
authors.lastname: Jaff
authors.forename: L F
authors.initials: LF
authors.lastname: Satler
authors.forename: R
authors.initials: R
authors.lastname: Mehran
authors.forename: M B
authors.initials: MB
authors.lastname: Leon
mesh_terms: D000208:Acute Disease; D000368:Aged; D000792:Angiography; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005528:Foot / Q000098:blood supply*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007511:Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage*; D015912:Thrombolytic Therapy / Q000379:methods; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; C087896:reteplase; D010959:Tissue Plasminogen Activator