title: Effects of premedication with oral hydroxyzine on patient motion during inhalation of 32% xenon for regional cerebral blood flow mapping.
abstract: Because of its anesthetic properties, inhalation of 30-35% Xenon is associated with uncontrolled patient motion in 3-15% of the cases. This constitutes a major setback to regional cerebral blood flow studies with Xenon-enhanced computed tomography (Xe-CT CBF). The present study attempted to determine the effects of oral premedication with hydroxyzine (H) in the control of motion. Patients scheduled for Xe-CT CBF, aged 20-55 years, were randomly allocated to 3 groups: H 50 mg (n = 41), H 100 mg (n = 36) or Placebo (n = 43). The drugs were administered orally 90 minutes before Xenon inhalation. This consisted a gas mixture of 32% Xe and 25% oxygen. Motion was classified as controlled or uncontrolled depending on whether CBF data acquisition was possible or not. Anxiolysis and sedation were evaluated by a visual analogue scale. Motion was significantly reduced in the H 50 mg (0.8% vs 2.5% in the H 100 mg and 6.7% in the Placebo group). An anxiolytic effect of hydroxyzine was suggested.
authors.affiliation: Department of Anesthesiology, University of Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Sesay
authors.forename: A
authors.initials: A
authors.lastname: Tanaka
authors.forename: V
authors.initials: V
authors.lastname: Dousset
authors.forename: J M
authors.initials: JM
authors.lastname: Caillé
authors.forename: P
authors.initials: P
authors.lastname: Maurette
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002560:Cerebrovascular Circulation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011292:Premedication; D014057:Tomography, X-Ray Computed / Q000379:methods; D014978:Xenon / Q000009:adverse effects
chemical_list: D006993:Hypnotics and Sedatives; D006919:Hydroxyzine; D014978:Xenon