title: Development and validation of a GC/MS method for determination of phenolic xenoestrogens in aquatic samples.
abstract: A simple and sensitive GC/MS method for the quantitative determination of the estrogenic phenolic compounds 4-nonylphenol, 4-t-octylphenol, bisphenol A, 3-t-butyl-4-hydroxyanisole, 2-t-butyl-4-methylphenol, 4-hydroxybiphenyl, 2-hydroxybiphenyl, 4-chloro-3-methylphenol, and 4-chloro-2-methylphenol in aquatic samples was developed. The method for assessing their occurrence in sewage, surface and drinking waters consists of solid phase extraction (SPE) using a polystyrene copolymer phase. After methylation of the extract HRGC/LRMS analysis was possible without any clean up, even in raw sewage samples. Limits of detection and determination were between <0.01 and 0.05 ng/l and 0.01 and 0.05 ng/l, respectively. Recoveries were above 70% with exception of 3-t-butyl-4-hydroxyanisole.
authors.affiliation: Institute of Organic Chemistry, University of Tübingen, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Bolz
authors.forename: W
authors.initials: W
authors.lastname: Körner
authors.forename: H
authors.initials: H
authors.lastname: Hagenmaier
mesh_terms: D004967:Estrogens / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010636:Phenols / Q000032:analysis*; D012680:Sensitivity and Specificity; D012722:Sewage / Q000032:analysis; D014867:Water / Q000737:chemistry*; D015262:Xenobiotics / Q000032:analysis*
chemical_list: D004967:Estrogens; D010636:Phenols; D012722:Sewage; D015262:Xenobiotics; D014867:Water; C041594:4-nonylphenol