Antifungal activity of magnolol and honokiol.
Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.
Bang
K H
KH
R & D Center, Kolon Pharmaceutical Inc., Taejon, Korea.
Kim
Y K
YK
Min
B S
BS
Na
M K
MK
Rhee
Y H
YH
Lee
J P
JP
Bae
K H
KH
D000935:Antifungal Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D006801:Humans; D017705:Lignans; D008826:Microbial Sensitivity Tests; D000498:Allyl Compounds; D010636:Phenols
D000935:Antifungal Agents; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols