Replication and recombination intersect.
A bacterial housekeeping function, which requires both recombination and replication enzymes, has been identified that re-establishes inactivated replication forks under normal growth conditions. Some long-tract gene-conversion events initiated by double-strand breaks in yeast and mammalian cells can be attributed to recombination-directed DNA replication. Double-strand break repair in yeast has been shown to require both leading- and lagging-strand DNA synthesis. These observations suggest that the recombination and replication machinery cooperate to maintain genomic integrity.
Marians
K J
KJ
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. k-marians@ski.mskcc.org
D000818:Animals; D004261:DNA Replication / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D011995:Recombination, Genetic
D004269:DNA, Bacterial