[Significance of c-erbB-2 and PCNA expression in adenocarcinoma of uterine cervix].
OBJECTIVE
Significance of c-erbB-2 and PCNA expression in adenocarcinoma.


METHODS
Expression of c-erbB-2 and PCNA in 74 cases of adenocarcinoma of the uterine cervix was examined by immunohistochemistry.


RESULTS
The expression of c-erbB-2 was detected in 34 cases. The positive staining of c-erbB-2 was associated with increased lymph node metastasis (57.1% Vs 24.0%, P = 0.041) and lower 5-year survival rate (32.4% Vs 58.9%, P = 0.008). The average PCNA labelling index (PCNALI) was 40.6% (0.1%-91.4%). High PCNALI was associated with lymph node metastasis (56.4% Vs 38.5%, P = 0.016) and lower 5-year survival rate (28.7% Vs 64.4%, P = 0.005). Positive staining of c-erbB-2 were associated with high PCNALI (44.7% Vs 34.6%, P = 0.003).


CONCLUSIONS
c-erbB-2 and PCNALI were associated with malignant biological behavior and poor prognosis. They may be potential prognostic factors in cervical adenocarcinoma.
Huang
Y
Y
Cancer Hospital, Shanghai Medical University.
Cai
S
S
Yu
S
S
D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D000328:Adult; D000368:Aged; D000818:Animals; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D011817:Rabbits; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases