Evaluation of intravenous flavopiridol formulations.
Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.
Li
P
P
Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson, USA.
Patel
H
H
Tabibi
S E
SE
Vishnuvajjala
R
R
Yalkowsky
S H
SH
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000032:analysis*; D005419:Flavonoids / Q000008:administration & dosage / Q000032:analysis*; D007275:Injections, Intravenous; D019999:Pharmaceutical Solutions; D010880:Piperidines / Q000008:administration & dosage / Q000032:analysis*
D000970:Antineoplastic Agents; D005419:Flavonoids; D019999:Pharmaceutical Solutions; D010880:Piperidines; C077990:alvocidib