title: Frequency of Escherichia coli strains producing the cytotoxic necrotizing factor (CNF1) in nosocomial urinary tract infections.
abstract: The presence of cytotoxic necrotizing factor 1 (CNF1), together with various associated virulence factors (alpha-haemolysin, P-, S- and A-fimbriae), was screened in 175 uropathogenic Escherichia coli strains isolated from hospitalized adult patients. The cnf1 gene was detected in 30% of the selected strains independently of the severity of the clinical urinary infection. A significant association between CNF1, haemolytic activity and the products of the pap/sfa genes was found. However, CNF1 appeared not to play a major role in nosocomial E. coli urinary tract infections.
authors.affiliation: Unité INSERM 452, Faculté de Médecine, Nice and Laboratoire de Bactériologie, Hôpital ARCHET II, Nice, France. landraud@unice.fr
authors.forename: L
authors.initials: L
authors.lastname: Landraud
authors.forename: M
authors.initials: M
authors.lastname: Gauthier
authors.forename: T
authors.initials: T
authors.lastname: Fosse
authors.forename: P
authors.initials: P
authors.lastname: Boquet
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism*; D003428:Cross Infection / Q000382:microbiology* / Q000652:urine; D003603:Cytotoxins / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D004927:Escherichia coli Infections / Q000382:microbiology* / Q000652:urine; D029968:Escherichia coli Proteins; D005260:Female; D005798:Genes, Bacterial; D006460:Hemolysin Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D012097:Repressor Proteins; D014157:Transcription Factors; D014552:Urinary Tract Infections / Q000382:microbiology*; D014774:Virulence
chemical_list: D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D003603:Cytotoxins; D029968:Escherichia coli Proteins; D006460:Hemolysin Proteins; C086707:PapI protein, E coli; D012097:Repressor Proteins; D014157:Transcription Factors; C101637:ymcE protein, E coli; C060296:cytotoxic necrotizing factor type 1