title: Simplified use of mixed propofol and alfentanil for anesthesia in remote locations.
abstract: Total intravenous anesthesia (TIVA) is a useful technique in precarious situations in which anesthesia ventilators and medical gas can be difficult to obtain. The aim of the study is to compare TIVA technique using a simplified infusion scheme for propofol and alfentanil mixed together (45 ml of propofol 1% and 2,500 micrograms of alfentanil in a 50-ml syringe) with an inhalational anesthetic technique (isoflurane/N2O, sufentanil). Thirty-two American Society of Anesthesiologists physical status I patients undergoing orthopedic surgery were studied. Intubation conditions and hemodynamic responses to intubation were comparable in the two groups. Only patients receiving TIVA had responses to surgery. In the TIVA group, time to extubation was shorter (16 +/- 5 vs. 25 +/- 7 minutes) and postoperative requirement for morphine was lower (6.2% vs. 25%) than in the inhalation group (p < 0.05). TIVA using a mixture of propofol and alfentanil is a reliable technique of anesthesia in patients without multiple injuries.
authors.affiliation: Hôpital d'Instruction des Armées Begin, Service Anesthésie-Réanimation, Saint-Mandé, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Saïssy
mesh_terms: D000293:Adolescent; D000328:Adult; D015760:Alfentanil / Q000627:therapeutic use*; D000769:Anesthesia, Inhalation / Q000379:methods*; D000771:Anesthesia, Intravenous / Q000379:methods*; D018685:Anesthetics, Inhalation / Q000627:therapeutic use; D018686:Anesthetics, Intravenous / Q000627:therapeutic use*; D001182:Arthroscopy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007442:Intubation, Intratracheal; D007530:Isoflurane / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008887:Military Medicine / Q000379:methods*; D009609:Nitrous Oxide / Q000627:therapeutic use; D015742:Propofol / Q000627:therapeutic use*; D017409:Sufentanil / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D004338:Drug Combinations; D015760:Alfentanil; D017409:Sufentanil; D007530:Isoflurane; D009609:Nitrous Oxide; D015742:Propofol