The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers.
Spisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work the molecular target for this toxic agent has been analyzed. In the presence of spisulosine, cultured cells change their morphology, first acquiring a fusiform morphology, and later becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells indicate the absence of actin stress fibers.
Cuadros
R
R
Centro de Biología Molecular 'Severo Ochoa' (CSIC-UAM), Universidad Autónoma de Madrid, 28049, Madrid, Spain.
Montejo de Garcini
E
E
Wandosell
F
F
Faircloth
G
G
Fernández-Sousa
J M
JM
Avila
J
J
D000199:Actins / Q000187:drug effects*; D000818:Animals; D049872:Bivalvia / Q000737:chemistry; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D048429:Cell Size / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D008055:Lipids / Q000494:pharmacology*; D008246:Lysophospholipids / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000199:Actins; D008055:Lipids; D008246:Lysophospholipids; C408363:spisulosine