title: Antipyretic, antinociceptive and anti-inflammatory activity of Premna herbacea roots.
abstract: The alcoholic extract of the roots of Premna herbacea was investigated for its antipyretic, antinociceptive and anti-inflammatory potential in animal models. The extract, when administered orally to mice has been found to be safe up to a dose of 8.0 g/kg. A significant antipyretic effect has been observed in rabbits while mild antinociceptive effects were evidenced in mice when tested by chemical as well as thermal methods. The extract did not exhibit any anti-inflammatory activity in acute but significantly reduced the chronic inflammation.
authors.affiliation: Medicinal Chemistry Research Centre, Institute of Pharmacology, Madras Medical College, Chennai, India.
authors.forename: N
authors.initials: N
authors.lastname: Narayanan
authors.forename: P
authors.initials: P
authors.lastname: Thirugnanasambantham
authors.forename: S
authors.initials: S
authors.lastname: Viswanathan
authors.forename: M
authors.initials: M
authors.lastname: Kannappa Reddy
authors.forename: V
authors.initials: V
authors.lastname: Vijayasekaran
authors.forename: E
authors.initials: E
authors.lastname: Sukumar
mesh_terms: D019342:Acetic Acid; D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D007194:India; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D010946:Plants, Medicinal; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013035:Spasm / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D000890:Anti-Infective Agents; D010936:Plant Extracts; D019342:Acetic Acid