Effectiveness and utility of chemical labyrinthectomy with streptomycin using osmotic pump.
To investigate the utility of osmotic pumps, labyrinthectomy was performed surgically (surgical group) or chemically with 30% streptomycin sulfate (SM) using osmotic pumps (SM group) in guinea pigs. After treatment, no statistical difference was observed in the frequency of spontaneous nystagmus and the degree of yaw head tilt between the groups. These data indicate the reliability and efficacy of osmotic pumps, and it might be possible to make guinea pig models using osmotic pumps to predict various grades of damage in the vestibular periphery of humans.
Shimogori
H
H
Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. shimo-h@po.cc.yamaguchi-u.ac.jp
Yamashita
H
H
D000818:Animals; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D007758:Ear, Inner / Q000473:pathology / Q000601:surgery*; D006168:Guinea Pigs; D008297:Male; D009759:Nystagmus, Pathologic / Q000209:etiology*; D009995:Osmosis; D018709:Statistics, Nonparametric; D013307:Streptomycin / Q000008:administration & dosage*
D013307:Streptomycin