title: Vagal paraganglioma: the Jefferson experience.
abstract: Vagal paraganglioma is a rare tumor of neural crest origin. Although the literature is in agreement with regard to epidemiology, diagnosis, and tumor biology, there is some controversy over treatment modalities for these patients. We performed a nonrandomized retrospective study in a large single-institution series of patients (n = 19) in whom vagal paraganglioma was diagnosed. General statistics included age, male/female ratio, tumor size, and duration of follow-up. Other variables such as signs and symptoms at presentation, family history, multicentricity, metastatic disease, and secretion of catecholamines were included. CT scan, MRI, and angiography were used in combination for diagnostic purposes as well as for treatment planning. Preoperative embolization was performed in 5 of the more recently treated patients. Current issues regarding the use of preoperative embolization and choice of surgical approach were analyzed. In this article the possibility and sequela of vagus nerve-sparing procedures will be presented. Operative complications and postoperative morbidity related to cranial neuropathies will be discussed. The rationale for performing adjunct procedures, including cricopharyngeal myotomy and vocal fold medialization, to facilitate the rehabilitation of patients with postoperative cranial nerve deficits will be given. Our findings and recommendations will be compared with currently accepted treatment protocols in conjunction with a review of the literature.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Miller
authors.forename: M S
authors.initials: MS
authors.lastname: Boon
authors.forename: J P
authors.initials: JP
authors.lastname: Atkins
authors.forename: L D
authors.initials: LD
authors.lastname: Lowry
mesh_terms: D000328:Adult; D000368:Aged; D003390:Cranial Nerve Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D010235:Paraganglioma / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies; D020421:Vagus Nerve Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery