Benzodiazepine receptor distribution and cerebral blood flow in early blindness--a PET study.
We studied benzodiazepine receptor (BZR) distribution, which is thought to be affected by neuronal density in the cerebral cortex, and CBF using [11C]flumazenil and [15O]water PET in early blind (EB) and in blindfold sighted control (SC) subjects. PET images were co-registered to the subject's MRI. Using SPM96, MRI images were normalized in the Talairach and Tournoux coordinate system, and accordingly MRI-registered PET images were spatially normalized. Statistical parametric maps were computed on a voxel-by-voxel basis, using the general linear model. CBF for EB was significantly larger in the Brodmann area 17 and 18, especially anterior area, than that for SC, while there was no significant difference in BZR distribution. Our BZR data suggest that the amount of neurons do not change due to early visual deprivation in the visual cortex, in spite of high CBF in visual cortex of EB subjects.
Mishina
M
M
Second Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Senda
M
M
Kiyosawa
M
M
De Volder
A
A
Toyama
H
H
Ishiwata
K
K
Oda
K
K
Kimura
Y
Y
Nakano
H
H
Ohyama
M
M
Kitamura
S
S
Katayama
Y
Y
D000328:Adult; D001766:Blindness / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D006801:Humans; D008297:Male; D011963:Receptors, GABA-A / Q000378:metabolism*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D014793:Visual Cortex / Q000098:blood supply* / Q000378:metabolism*
D011963:Receptors, GABA-A