[The effectiveness of G-CSF and GM-CSF in the adjunctive treatment of infections complicating chemotherapy of non-Hodgkin's lymphoma in children. Report of Polish Pediatric Leukemia/Lymphoma Treatment Group].
Total number of 252 cycles of GM-CSF-Leucomax Sandoz (5 mg/kg/day s.c.) and/or G-CSF Filgrastim Hoffmann-La Roche (5-10 mg/kg/day s.c.) was applied in 124 children aged from 0.5-20 years during neutropenia associated with chemotherapy of non-Hodgkin's lymphoma (NHL). Twenty four children with NHL treated according to the same chemotherapy protocol but without G-CSF and GM-CSF served as a control group. Our study have demonstrated the good efficacy of both G-CSF and GM-CSF therapy. They shortened the period of neutropenia, reduced the number of febrile days, infection's duration and decreased the frequency of infectious complications.
Chybicka
A
A
Kliniki Hematologii i Chorób Rozrostowych Dzieci Akademii Medycznej we Wrocławiu.
Bogusławska-Jaworska
J
J
Rosińska
B
B
Wecławek-Tompol
J
J
Armata
J
J
Balcerska
A
A
Balwierz
W
W
Bubała
H
H
Drabko
K
K
Eliasińska
A
A
Kedziora
M
M
Sońta-Jakimczyk
D
D
Sopyło
B
B
Kołecki
P
P
Kowalczyk
J
J
Matysiak
M
M
Rokicka-Milewska
R
R
Stefaniak
M J
MJ
Stańczak
E
E
Stencel
D
D
Wysocki
M
M
Płoszyńska
A
A
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007239:Infections / Q000150:complications* / Q000188:drug therapy*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D009503:Neutropenia / Q000150:complications*; D011044:Poland; D015996:Survival Rate
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor