[Experimental study of anti-tumour effect of rhTNF alpha on the laryngeal squamous cell carcinoma].
The anti-tumor effect of rhTNF alpha (recombination human tumor necrosis factor) with three different doses on laryngeal squamous cancer was investigated in nude mice. The results indicated that the higher and the middle doses of rhTNF alpha had significant antitumour effect against laryngeal cancer in BALB/C nude mice. The inhibitory rate of tumor growth was 54.4%(P < 0.05). The lower dose of rhTNF alpha also had antitumour effect but the cancer grew again when rhTNF alpha was stopped. Ultrastructural changes showed that the plasma membrane and the nucleus envelope of the tumor cell were destroyed and the number of lysosomes increased, fibroid material could be seen in the cancer capillary.
Ye
J
J
Second Affiliated Hospital, Harbin Medical University.
Xu
X
X
Shi
L
L
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D007167:Immunotherapy; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011897:Random Allocation; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D014409:Tumor Necrosis Factor-alpha / Q000627:therapeutic use*
D011993:Recombinant Fusion Proteins; D014409:Tumor Necrosis Factor-alpha