Amplifying effect of dietary taurine on the induction of cytochrome P-450 and on the urinary excretion of ascorbic acid in rats fed on phenobarbital-containing diets.
Dietary taurine amplified the induction of cytochrome P-450 and the urinary excretion of ascorbic acid in rats fed on phenobarbital (PB)-containing diets. These facts suggest that taurine could influence the hepatic metabolism of xenobiotics via the induction of drug-metabolizing enzymes (DME) and the ascorbic acid metabolism. Taurine might improve the function of DME exposed by some xenobiotics.
Mochizuki
H
H
School of Food and Nutritional Sciences, The University of Shizuoka, Japan.
Takido
J
J
Oda
H
H
Yokogoshi
H
H
D000818:Animals; D001205:Ascorbic Acid / Q000652:urine*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004032:Diet; D004790:Enzyme Induction; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000008:administration & dosage*
D013654:Taurine; D003577:Cytochrome P-450 Enzyme System; D001205:Ascorbic Acid; D010634:Phenobarbital