title: [Diagnosis and therapy of non-occlusive mesenteric ischemia (NOMI)].
abstract: Pathophysiologically, the non-occlusive mesenteric ischemia (NOMI) results from reduced blood supply to the intestine, caused by "low cardiac output syndrome", or the use of certain drugs leading to intestinal vasoconstriction and stasis of the microcirculation. Regardless of the aetiopathogenesis, the patient's prognosis crucially depends on rapid diagnosis and initiation of adequate medical or surgical intervention. In a 10-year retrospective chart analysis (1989 to 1998) we identified a total of 62 patients that demonstrated classical features of NOMI. The investigation focused on patients' history, risk factors, clinical symptoms, diagnostic procedures and patient's clinical outcome. The most important associated risk factors and concomitant diseases were reduced cardiac output (caused by preexisting heart failure), renal diseases, diabetes and the use of some specific drugs (digitalis, furosemide, ergotamine). Except for leucocytosis, elevated serum lactate and an increased CK/CK-MB level, all laboratory findings were unspecific. Using abdominal ultrasound and plain abdominal x-ray, 80% of the cases showed positive signs of ileus, subileus and free intraabdominal fluid. The angiographic diagnostics (mesentericography) of non-occlusive mesenteric ischemia showed the typical signs of peripheral vasoconstriction in 90% of the cases. Fifty three patients (86%) presenting with peritoneal signs underwent operative bowel exploration. Necrotic bowel had to be resected in 37 cases (60%). The overall letality was 58%. The progress made in better understanding the pathophysiology of NOMI has led to differential treatment of the disease. Close cooperation between surgeons and radiologists, coupled with early diagnosis and prompt treatment are necessary to optimize the clinical outcome.
authors.affiliation: Klinik für Chirurgie, Universitätsklinikum Lübeck.
authors.forename: H
authors.initials: H
authors.lastname: Stöckmann
authors.forename: U J
authors.initials: UJ
authors.lastname: Roblick
authors.forename: N
authors.initials: N
authors.lastname: Kluge
authors.forename: U
authors.initials: U
authors.lastname: Kunze
authors.forename: H
authors.initials: H
authors.lastname: Schimmelpenning
authors.forename: P
authors.initials: P
authors.lastname: Kujath
authors.forename: G
authors.initials: G
authors.lastname: Müller
authors.forename: H P
authors.initials: HP
authors.lastname: Bruch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D008297:Male; D008643:Mesentery / Q000098:blood supply*; D008875:Middle Aged; D009336:Necrosis; D011379:Prognosis; D015996:Survival Rate