title: Bacillus thuringiensis crystal delta-endotoxin: role of proteases in the conversion of protoxin to toxin.
abstract: The conversion of delta-endoprotoxins of Bacillus thuringiensis to active toxins is mediated by trypsin, insect gut (exogenous) and bacterial (endogenous) proteases. The biochemical aspects of exogenous and endogenous proteases involved in the conversion of protoxin to toxin are reviewed. Perhaps, these proteases also play a role in influencing the host range of toxin and in the development of resistance to toxin.
authors.affiliation: Department of Biochemistry, Osmania University, Hyderabad, India.
authors.forename: V
authors.initials: V
authors.lastname: Rukmini
authors.forename: C Y
authors.initials: CY
authors.lastname: Reddy
authors.forename: G
authors.initials: G
authors.lastname: Venkateswerlu
mesh_terms: D000818:Animals; D001413:Bacillus thuringiensis / Q000235:genetics / Q000378:metabolism*; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000235:genetics / Q000378:metabolism*; D004064:Digestive System / Q000201:enzymology; D010450:Endopeptidases / Q000378:metabolism; D004731:Endotoxins / Q000235:genetics / Q000378:metabolism*; D006460:Hemolysin Proteins; D007814:Larva; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D014357:Trypsin / Q000378:metabolism
chemical_list: D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004731:Endotoxins; D006460:Hemolysin Proteins; D011498:Protein Precursors; C030956:insecticidal crystal protein, Bacillus Thuringiensis; D010450:Endopeptidases; D014357:Trypsin