Long-term oral and craniofacial complications following pediatric bone marrow transplantation.
Bone marrow transplantation (BMT) has become a common form of treatment for childhood diseases and disorders that directly or indirectly affect the production of stem cells which give origin to blood and immune system elements. The pre-transplant protocols include, but are not limited to, chemotherapy and/or radiotherapy, which can cause considerable acute and long-term undesired effects in the oral cavity and the craniofacial complex. This manuscript discusses the sequelae that a pediatric dentist may encounter when treating a BMT survivor.
da Fonseca
M A
MA
Department of Orthodontics and Pediatric Dentistry, University of Michigan School of Dentistry, Ann Arbor, USA.
D000208:Acute Disease; D001847:Bone Diseases / Q000139:chemically induced / Q000209:etiology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002908:Chronic Disease; D003729:Dental Care; D005147:Facial Bones / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D009059:Mouth Diseases / Q000139:chemically induced / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D012886:Skull / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D013234:Stem Cells / Q000502:physiology; D019172:Transplantation Conditioning / Q000009:adverse effects*