The nucleolus: an old factory with unexpected capabilities.
The function of the nucleolus as a factory for assembling ribosomal subunits is well established, but many unrelated activities have been discovered over the past decade. Our understanding of the dynamics of nucleolar structure and its reassembly at the end of mitosis has recently advanced and the small nucleolar RNAs have been shown to be major players in the processing and modification of preribosomal RNA. Unexpectedly, the nucleolus also seems to play a role in nuclear export, sequestering regulatory molecules, modifying small RNAs, assembling ribonucleoprotein (RNP) and controlling aging.
Olson
M O
MO
Dept of Biochemistry, The University of Mississippi Medical Center, Jackson, MS 39216-4505, USA. Molson@biochem.umsmed.edu
Dundr
M
M
Szebeni
A
A
D000818:Animals; D002466:Cell Nucleolus / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans; D008938:Mitosis; D009687:Nuclear Proteins; D012318:RNA Polymerase I; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000378:metabolism; D012270:Ribosomes / Q000235:genetics / Q000502:physiology / Q000648:ultrastructure
D009687:Nuclear Proteins; D012335:RNA, Ribosomal; D012318:RNA Polymerase I