title: Synthesis and pharmacological properties of 1-(4-substituted)butyl derivatives of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimi dine-5 -carboxylic acid.
abstract: The synthesis of 1-(4-substituted)butyl derivatives of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimid ine-5- carboxylic acid and the results of the preliminary pharmacological screening are described in this paper. Some of them showed a weak analgesic action and caused suppression of the spontaneous locomotor activity of mice.
authors.affiliation: Department of Chemistry of Drugs, Wrocław Medical University, Poland.
authors.forename: H
authors.initials: H
authors.lastname: Sladowska
authors.forename: M
authors.initials: M
authors.lastname: Sieklucka-Dziuba
authors.forename: R
authors.initials: R
authors.lastname: Rejdak
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D018712:Analgesics, Non-Narcotic; D011725:Pyridines; D011744:Pyrimidinones