Blood coagulation: The outstanding hydrophobic residues.
Newly determined crystal structures suggest that the membrane-binding C2 domains of blood coagulation cofactors Va and VIIIa bind anionic phospholipids through protruding solvent-exposed hydrophobic residues, aided by a crown of positively charged residues and by specific hydrogen-bonding side chains.
Pellequer
J L
JL
Department of Molecular Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla 92037, USA.
Gale
A J
AJ
Getzoff
E D
ED
D001665:Binding Sites; D001777:Blood Coagulation; D015944:Factor VIIIa / Q000235:genetics / Q000378:metabolism*; D015943:Factor Va / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016296:Mutagenesis; D010743:Phospholipids / Q000378:metabolism*
D010743:Phospholipids; D015943:Factor Va; D015944:Factor VIIIa