title: Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex.
abstract: The distribution of tachykinin NK(1) and NK(3) receptors in the prefrontal (Brodmann area 9) and visual cortex (Brodmann area 17) of formalin-fixed postmortem human brain tissue was studied by immunohistochemistry. NK(1)-like immunoreactivity (NK(1)-LI) was observed as a thin band at the cortical surface and dots of NK(1)-LI localised on small non-pyramidal cells and in the neuropil (layers I-III). NK(3)-LI was found in beaded fibres and cells with astrocyte-like morphology in the superficial cortical layers and white matter. Dots of NK(3)-LI were prominent in the neuropil and on pyramidal (layers III/V) and non-pyramidal (layers V/VI) cells. The NK(3)-LI was more abundant and widespread than the NK(1)-LI. This is the first report of the distribution of the NK(1) receptor in the prefrontal and visual cortex of the human brain by immunohistochemistry.
authors.affiliation: Neuroscience Institute of Schizophrenia and Allied Disorders and School of Biomedical Sciences, Faculty of Medicine and Health Sciences, The University of, Newcastle, Australia. ptooney@mail.newcastle.edu.au
authors.forename: P A
authors.initials: PA
authors.lastname: Tooney
authors.forename: G G
authors.initials: GG
authors.lastname: Au
authors.forename: L A
authors.initials: LA
authors.lastname: Chahl
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D001253:Astrocytes / Q000737:chemistry / Q000378:metabolism; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017397:Prefrontal Cortex / Q000737:chemistry / Q000378:metabolism*; D018039:Receptors, Tachykinin / Q000378:metabolism*; D016610:Tissue Embedding; D014793:Visual Cortex / Q000737:chemistry / Q000378:metabolism*
chemical_list: D018039:Receptors, Tachykinin