title: Multiple alleles of Treponema pallidum repeat gene D in Treponema pallidum isolates.
abstract: Two new tprD alleles have been identified in Treponema pallidum: tprD2 is found in 7 of 12 T. pallidum subsp. pallidum isolates and 7 of 8 non-pallidum isolates, and tprD3 is found in one T. pallidum subsp. pertenue isolate. Antibodies against TprD2 are found in persons with syphilis, demonstrating that tprD2 is expressed during infection.
authors.affiliation: Departments of Medicine and Pathobiology, University of Washington, Seattle, Washington 98195-7185, USA.
authors.forename: A
authors.initials: A
authors.lastname: Centurion-Lara
authors.forename: E S
authors.initials: ES
authors.lastname: Sun
authors.forename: L K
authors.initials: LK
authors.lastname: Barrett
authors.forename: C
authors.initials: C
authors.lastname: Castro
authors.forename: S A
authors.initials: SA
authors.lastname: Lukehart
authors.forename: W C
authors.initials: WC
authors.lastname: Van Voorhis
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000907:Antibodies, Bacterial / Q000097:blood; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics* / Q000276:immunology; D020440:Gene Duplication; D005798:Genes, Bacterial; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D013587:Syphilis / Q000097:blood; D014210:Treponema pallidum / Q000235:genetics* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; C406409:Tpr protein, Treponema