title: Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies.
abstract: In 16 patients with probable Alzheimer's disease (AD; NINDS criteria, age range 56-78 years), gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) absolute and fractional volumes were measured with an unsupervised multiparametric post-processing segmentation method based on estimates of relaxation rates R1, R2 (R1 = 1/T1; R2 = 1/T2) and proton density [N(H)] from conventional spin-echo studies (Alfano et al. Magn. Reson. Med. 1997;37:84-93). Global brain atrophy, and GM and WM fractions significantly correlated with Mini-Mental Status Examination and Blessed Dementia Scale scores. Compared with normals, brain compartments in AD patients showed decreased GM (-6.84 +/- 1.58%) and WM fractions (-9.79 +/- 2.47%) and increased CSF fractions (+58.80 +/- 10.37%). Changes were more evident in early-onset AD patients. In AD, measurement of global brain atrophy obtained by a computerized procedure based on routine magnetic resonance studies could complement the information provided by neuropsychological tests for the assessment of disease severity.
authors.affiliation: Diagnostic Imaging Department, CNR, Università di Napoli Federico II, Napoli, Italy. brunetti@unina.it
authors.forename: A
authors.initials: A
authors.lastname: Brunetti
authors.forename: A
authors.initials: A
authors.lastname: Postiglione
authors.forename: E
authors.initials: E
authors.lastname: Tedeschi
authors.forename: A
authors.initials: A
authors.lastname: Ciarmiello
authors.forename: M
authors.initials: M
authors.lastname: Quarantelli
authors.forename: E M
authors.initials: EM
authors.lastname: Covelli
authors.forename: G
authors.initials: G
authors.lastname: Milan
authors.forename: M
authors.initials: M
authors.lastname: Larobina
authors.forename: A
authors.initials: A
authors.lastname: Soricelli
authors.forename: A
authors.initials: A
authors.lastname: Sodano
authors.forename: B
authors.initials: B
authors.lastname: Alfano
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests