title: Reproducible erythroid aplasia caused by mycophenolate mofetil.
abstract: Anemia secondary to mycophenolate mofetil (MMF) was recently described in experimental animals. A clinical association between MMF and anemia has been observed, but there are no proven reports. We describe a girl with chronic graft failure who developed erythroid aplasia under immunosuppression with MMF. She showed prompt resolution when MMF was discontinued and a recurrence of this clinical course when MMF was restarted. As re-challenge with a medication is the most definitive approach for showing a direct relationship between the drug and the side effect, this case clearly demonstrates that MMF can cause erythroid aplasia.
authors.affiliation: Department of Pediatrics, Vienna Medical School AKH Wien, Vienna, Austria.
authors.forename: K
authors.initials: K
authors.lastname: Arbeiter
authors.forename: L
authors.initials: L
authors.lastname: Greenbaum
authors.forename: E
authors.initials: E
authors.lastname: Balzar
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: F
authors.initials: F
authors.lastname: Hofmeister
authors.forename: B
authors.initials: B
authors.lastname: Bidmon
authors.forename: C
authors.initials: C
authors.lastname: Aufricht
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000209:etiology; D016030:Kidney Transplantation; D009173:Mycophenolic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011183:Postoperative Complications; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*
chemical_list: D009173:Mycophenolic Acid