title: [A case of advanced hepatocellular carcinoma with lung and bone metastases effectively treated by orally administered UFT].
abstract: A 52-year-old male underwent hepatic subsegmentectomy for hepatocellular carcinoma (HCC). Five months later, a recurrent tumor was found in the liver and transcatheter arterial embolization (TAE) was performed. However, recurrent tumors were growing rapidly with multiple lung and bone metastases. The titer of serum AFP was elevated to 896,095 ng/ml and the titer of serum PIVKA-II was elevated to 1294.5 AU/ml. The patient was treated by oral administration of UFT (600 mg/day). Two weeks later, his general condition was improved, and several months later, the liver tumor, multiple lung metastases and multiple bone metastases had almost disappeared. The titers of serum AFP and PIVKA-II were reduced to the normal range. He has maintained a good state of health for about four years now. This case suggests the clinical usefulness of UFT for advanced HCC.
authors.affiliation: Dept. of Internal Medicine, Kokura National Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Sadamoto
authors.forename: M
authors.initials: M
authors.lastname: Koujima
authors.forename: S
authors.initials: S
authors.lastname: Itaba
authors.forename: Y
authors.initials: Y
authors.lastname: Miyagi
authors.forename: M
authors.initials: M
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Motosato
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Siomichi
authors.forename: Y
authors.initials: Y
authors.lastname: Amagase
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015415:Biomarkers; D001859:Bone Neoplasms / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D015415:Biomarkers; D011498:Protein Precursors; D000509:alpha-Fetoproteins; D005641:Tegafur; C008208:acarboxyprothrombin; D014498:Uracil; D011516:Prothrombin