Cognitive neuropharmacology: new perspectives for the pharmacology of cognition.
Taking its roots both in neuropharmacology and in cognitive science, cognitive neuropharmacology is an emerging approach in the field of psychopharmacology. It attempts to use theoretical knowledge to understand the biochemical bases of cognition and the mode of action of the commonly used drugs and to find new brain-targeted therapeutics. The aim of the present article is to throw up the main characteristics of this way of research. It is defined in comparison with its neighbouring approaches and by presenting its own rationale. Its particular methods mainly concern the animal modelling of the highest human cognitive functions and the original means of intra-cerebral drug administration. Finally, we present an illustrative example of a study in cognitive neuropharmacology and propose further perspectives.
Le Merrer
J
J
Laboratoire de Neurosciences Cognitives, Université Bordeaux I-CNRS UMR 5807, Bâtiment de Biologie Animale, Avenue des Facultés, Talence Cedex, 33405, France.
Noguès
X
X
D000818:Animals; D003071:Cognition / Q000187:drug effects*; D006801:Humans; D008568:Memory; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D013569:Synapses / Q000502:physiology
D011493:Protein Kinase C