title: Assessment of vestibular ototoxicity of ear drops by recording of vestibular evoked potentials to acceleration impulses.
abstract: BACKGROUND
  The cochlear ototoxicity of several ear drops is well documented in the literature, but very few studies exist on the vestibular ototoxicity of these topical drugs.
  
  
  OBJECTIVE
  To develop an animal model for the assessment of the vestibular ototoxicity of ear drops.
  
  
  METHODS
  Two animal groups, consisting of five fat sand rats (FSRs) each, underwent unilateral labyrinthectomy. Normal saline was topically applied into the middle ear cavity of rats in the first group for 7 days (control group). Rats in the second group were treated in the same way by topical gentamicin solution. Cochlear function was assessed by the recording of auditory evoked potential (ABPs) thresholds, and vestibular function was assessed by the recording of vestibular evoked potentials (VsEPs) to angular accelerations.
  
  
  RESULTS
  In the control group, except for the amplitude of the first wave, there was no significant difference in the VsEPs recorded before and after topical application. In the gentamicin group, VsEPs could not be recorded after 7 days, and ABPs were recorded in one case only, with a threshold of 100 dB sound pressure level (SPL).
  
  
  CONCLUSIONS
  VsEPs seem to be a reliable measure for evaluating the vestibular ototoxicity of topical ear drops.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Hadassah University Hospital and Medical School, Jerusalem, Israel.
authors.forename: J Y
authors.initials: JY
authors.lastname: Sichel
authors.forename: R
authors.initials: R
authors.lastname: Eliashar
authors.forename: M
authors.initials: M
authors.lastname: Plotnik
authors.forename: H
authors.initials: H
authors.lastname: Sohmer
authors.forename: J
authors.initials: J
authors.lastname: Elidan
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity; D015834:Cochlear Diseases / Q000139:chemically induced* / Q000503:physiopathology; D004195:Disease Models, Animal; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005839:Gentamicins / Q000008:administration & dosage / Q000633:toxicity; D005849:Gerbillinae; D019999:Pharmaceutical Solutions / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage / Q000633:toxicity; D015837:Vestibular Diseases / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D019999:Pharmaceutical Solutions; D012965:Sodium Chloride