title: A 356-Kb sequence of the subtelomeric part of the MHC Class I region.
abstract: The subtelomeric part of the MHC Class I region contains 11 of the 21 genes described on chromosome 6 at position 6p21.3. The general organization of those and other genes resident in the region was revealed by determining a 356,376 bp sequence. Potential exons for new genes were identified by computer analysis and a large number of ESTs were selected by testing the sequence by the BLAST algorithm against the GenBank nonredundant and EST databases. Most of the ESTs are clustered in two regions. In contrast, the whole HLA-gene region is crammed with LINE and SINE repeats, fragments of genes and microsatellites, which tends to hinder the identification of new genes.
authors.affiliation: UPR 41 CNRS Recombinaisons Génétiques, Faculté de Médecine, Rennes, France. annie.hampe@univ-rennes1.fr
authors.forename: A
authors.initials: A
authors.lastname: Hampe
authors.forename: O
authors.initials: O
authors.lastname: Coriton
authors.forename: N
authors.initials: N
authors.lastname: Andrieux
authors.forename: G
authors.initials: G
authors.lastname: Carn
authors.forename: M
authors.initials: M
authors.lastname: Lepourcelet
authors.forename: S
authors.initials: S
authors.lastname: Mottier
authors.forename: S
authors.initials: S
authors.lastname: Dréano
authors.forename: M T
authors.initials: MT
authors.lastname: Gatius
authors.forename: C
authors.initials: C
authors.lastname: Hitte
authors.forename: N
authors.initials: N
authors.lastname: Soriano
authors.forename: F
authors.initials: F
authors.lastname: Galibert
mesh_terms: D000818:Animals; D018244:Chromosomes, Artificial, Yeast; D016208:Databases, Factual; D020224:Expressed Sequence Tags; D005805:Genes, MHC Class I; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012091:Repetitive Sequences, Nucleic Acid; D016615:Telomere