Interaction of the effects between vitamin D receptor polymorphism and exercise training on bone metabolism.
Bone metabolism is strongly influenced by heredity and environmental factors. To investigate interaction of the effects between vitamin D receptor polymorphism by Fok I and resistance exercise training on bone metabolism, young male subjects with FF genotype (F, n = 10) and Ff or ff genotypes (f, n = 10) followed 1 mo of weight training, and changes in bone metabolism were compared. An additional 14 subjects served as a sedentary control. Biomarkers of bone formation, bone-specific alkaline phosphatase, and osteocalcin were significantly increased by training in both F and f groups. 1, 25-Dihydroxyvitamin D(3), known to upregulate bone formation, was also increased by the training in the f but not in the F group. Bone resorption assessed by cross-linked NH(2)-terminal telopeptide of type I collagen was significantly suppressed by the training, and the decrease in F was greater and longer lasting than that in f group. In conclusion, stimulation of bone formation and suppression of bone resorption occurred within 1 mo in young men. Despite a significant increase in 1,25-dihydroxyvitamin D(3) in the f group but not in the F group, the response of bone metabolism to the training in the F was similar to or greater than that in f group, suggesting a functional difference between vitamin D receptor genotypes f and F.
Tajima
O
O
Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan.
Ashizawa
N
N
Ishii
T
T
Amagai
H
H
Mashimo
T
T
Liu
L J
LJ
Saitoh
S
S
Tokuyama
K
K
Suzuki
M
M
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001846:Bone Development; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D002117:Calcitriol / Q000097:blood; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D015444:Exercise / Q000502:physiology*; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D015999:Multivariate Analysis; D015675:Osteocalcin / Q000097:blood; D010455:Peptides / Q000097:blood; D010809:Physical Fitness; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D044465:White People
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; D018167:Receptors, Calcitriol; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase; D002117:Calcitriol