[Age characteristics of K(+) transport in the rat distal colon].
In vitro and in vivo experiments with perfusion in 20- and 60-day old rats revealed that K+ absorption in the gut as well as 86Rb uptake in the distal colon was significantly higher in younger rats due probable, to the higher activity of the apex-located K+-dependent ATPase and lower activity of the basolateral K+-carriers. The luminal blockade of K+ absorbing pumps with ouabain or omeprazole resulted in a decrease of the K+ absorption and K2 accumulation in skeletal muscles. The higher K+-absorbing/K_ secreting mechanisms ratio in younger rats contributes to the positive potassium balance.
Aĭzman
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RI
Novosibirsk State Pedagogical University, Novosibirsk, 630126, Viluiskaya St., 28, Russia.
Borovets
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EN
Gerasev
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AD
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D003106:Colon / Q000201:enzymology / Q000378:metabolism*; D017506:H(+)-K(+)-Exchanging ATPase / Q000378:metabolism; D007408:Intestinal Absorption; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000378:metabolism; D028021:Sodium-Potassium-Chloride Symporters; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D002352:Carrier Proteins; D002712:Chlorides; D028021:Sodium-Potassium-Chloride Symporters; D012964:Sodium; D000251:Adenosine Triphosphatases; D017506:H(+)-K(+)-Exchanging ATPase; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium