Delayed effects of exercise on the plasma leptin concentration.
Recent studies have concluded that a single exercise session has no immediate effect on the plasma concentration of leptin, a putative satiety factor. We tested the hypothesis that an increase in energy expenditure would decrease the leptin concentration but the effects would be manifest in a 48-hour period following exercise. Eleven active males completed two treadmill exercise sessions with different energy expenditure (800 or 1,500 kcal) at 70% maximal O2 consumption (Vo2max). Subjects maintained constant energy intake on the day before, the day of, and 2 days after exercise, as verified by dietary recall. Compared with preexercise in either exercise session, there were no differences in plasma leptin concentrations following exercise (0 and 24 hours postexercise) except at 48 hours postexercise, where an approximately 30% decrease (P < .05) was observed. With either duration of exercise, plasma glucose increased about 10% (P < .05), insulin decreased 35% to 46% (P < .05), and cortisol increased 41% to 50% (P < .05, 1,500 kcal only) immediately following exercise, but returned to preexercise values at 24 and 48 hours postexercise. A statistically significant correlation was observed between the changes in leptin and insulin (r = .49, P < .0001). Single exercise sessions of varying energy expenditure decreased the plasma leptin concentration after 48 hours in association with a preceding decrease in insulin.
Essig
D A
DA
Department of Exercise Science, School of Public Health, University of South Carolina, Columbia, USA.
Alderson
N L
NL
Ferguson
M A
MA
Bartoli
W P
WP
Durstine
J L
JL
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004032:Diet; D002149:Energy Intake; D004734:Energy Metabolism; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption; D010807:Physical Endurance; D005082:Physical Exertion / Q000502:physiology*; D012016:Reference Values; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D006854:Hydrocortisone