Relationship between Ras pathways and cell cycle control.
The ordered execution of the two main events of cellular reproduction, duplication of the genome and cell division, characterize progression through the cell cycle. Cultured cells can be switched between cycling and non-cycling states by alteration of extracellular conditions and the notion that a critical cellular control mechanism presides on this decision, whose temporal location is known as the restriction point, has become the focus for the study of how extracellular mitogenic signalling impinges upon the cell cycle to influence proliferation. This review attempts to cover the disparate pathways of Ras-mediated mitogenic signal transduction that impact upon restriction point control.
Ewen
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Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism*
D018631:ras Proteins