Effect of the addition of oxybenzone or octyl-methoxycinnamate on particle size of submicron emulsions.
The formulation of sunscreen products requires understanding of the solubilization of these products in different vehicles to obtain aesthetic preparations and to evaluate long-term stability. For this study, two different ultraviolet (UV) filters were selected: oxybenzone (powder) and octyl-methoxycinnamate (liquid). First, the solubility of these UV filters was tested using a three-component simplex-centroid design strategy. The mixtures were prepared with three oily phases used in this field of cosmetics: liquid paraffin, isopropyl myristate, and coconut oil. A phase diagram method was used to carry out a systematic study of submicron oil-in-water emulsions. Phase diagrams were produced by diluting fixed binary mixtures with water. The surfactant consisted of polyoxyethylene-20-sorbitan monostearate/sorbitan monostearate (50/50, w/w). The oily phase contained equal quantities of each oil studied. From this water/surfactant/oil ternary system, we selected two reference emulsions with receptively 75/5/20 and 68/7/25 proportions. Photon correlation spectroscopy (PCS) was used to investigate the influence of these two UV filters at several concentrations on droplet size and distribution of the oil droplets in the material. All emulsions were stored and checked every month for 6 months.
Marti-Mestres
G
G
Laboratoire de Technique Pharmaceutique Industrielle, Faculté de Pharmacie, Université de Montpellier I, France.
Nielloud
F
F
Fortuné
R
R
Fernandez
C
C
Maillols
H
H
D001577:Benzophenones / Q000737:chemistry*; D002934:Cinnamates / Q000737:chemistry*; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D012995:Solubility; D013473:Sunscreening Agents / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry
D001577:Benzophenones; D002934:Cinnamates; D004655:Emulsions; D009821:Oils; D013473:Sunscreening Agents; D013501:Surface-Active Agents; C005290:oxybenzone