A broad role for the zinc finger protein ZNF202 in human lipid metabolism.
The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families. Here we show that the ZNF202 gene product is a transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), and several genes involved in processes related to energy metabolism and vascular disease. Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia.
Wagner
S
S
Myriad Genetics, Inc., Salt Lake City, Utah 84108 and Novartis Institute for Biomedical Research, Summit, New Jersey 07901, USA. swagner@myriad.com
Hess
M A
MA
Ormonde-Hanson
P
P
Malandro
J
J
Hu
H
H
Chen
M
M
Kehrer
R
R
Frodsham
M
M
Schumacher
C
C
Beluch
M
M
Honer
C
C
Skolnick
M
M
Ballinger
D
D
Bowen
B R
BR
D017398:Alternative Splicing / Q000235:genetics; D001053:Apolipoproteins / Q000378:metabolism; D001665:Binding Sites; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002460:Cell Line; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D016208:Databases, Factual; D005786:Gene Expression Regulation; D008040:Genetic Linkage; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology / Q000235:genetics; D050356:Lipid Metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014589:Utah; D016335:Zinc Fingers / Q000235:genetics*
D001053:Apolipoproteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C115745:ZNF202 protein, human