Influence of different stent materials on endothelialization in vitro.
The objective of our study was to investigate the influence of different stent materials on endothelialization in vitro. Using the non-destructive Alamar Blue assay and scanning electron microscopy, we compared long-term growth and morphology of vascular cells on disks of three prospective stent materials, i.e., 316 L stainless steel, 18 K, and 24 K gold. Our results demonstrate superior human EC proliferative capacity on gold surfaces compared to that on 316 L stainless steel. Thus, both the hyperplasia and thrombotic complications which often follow stenting might be minimized by employing gold stents, which have a greater capacity than steel in supporting a functional neo-endothelium.
Nikolaychik
V
V
Medical College of Wisconsin, Department of Cardiovascular Medicine, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA.
Sahota
H
H
Keelan
M H
MH
Chawla
P S
PS
Hernandes
I
I
Ferguson
J J
JJ
Kipshidze
N
N
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology*; D004867:Equipment Design; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D008855:Microscopy, Electron, Scanning; D010078:Oxazines; D013193:Stainless Steel / Q000494:pharmacology*; D015607:Stents; D014966:Xanthenes
D007202:Indicators and Reagents; D010078:Oxazines; D014966:Xanthenes; D013193:Stainless Steel; C005843:resazurin; D006046:Gold