title: Effects of general anaesthesia vs. sedation on fertilization, cleavage and pregnancy rates in an IVF program.
abstract: Anaesthetic management for oocyte retrieval may interfere with the results and success rate of an in vitro fertilization (IVF) program. This study was conducted to compare the effects of two different anaesthetic techniques (general anaesthesia versus sedation) used for oocyte retrieval on IVF outcome. For general anaesthesia we used a combination of remifentanil (Ultiva) with either propofol or isoflurane in hypnotic concentrations. For sedation the protocol included midazolam, diazepam or propofol according to clinical needs. In total, 202 women were enrolled in the study. 96 women opted for sedation and 106 for general anaesthesia. The number of collected oocytes was significantly higher with general anaesthesia (10.54+/-5.43 [mean+/-SD]) than with sedation (6.25+/-3.65, p<0.0001), whereas the number of fertilized oocytes was not different (4.70+/-3.57 vs. 4.23+/-2.90). There were no significant differences in cleavage and pregnancy rates. We therefore believe that remifentanil-based general anaesthesia without nitrous oxide is a suitable alternative to sedation and may be recommended for IVF oocyte retrieval if general anaesthesia is requested.
authors.affiliation: Department of Obstetrics & Gynaecology, University of Saarland, Homburg/Saar, Germany.
authors.forename: M E
authors.initials: ME
authors.lastname: Hammadeh
authors.forename: W
authors.initials: W
authors.lastname: Wilhelm
authors.forename: A
authors.initials: A
authors.lastname: Huppert
authors.forename: P
authors.initials: P
authors.lastname: Rosenbaum
authors.forename: W
authors.initials: W
authors.lastname: Schmidt
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D002970:Cleavage Stage, Ovum; D016292:Procedural Sedation / Q000009:adverse effects; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro; D006801:Humans; D018587:Oocyte Donation; D010880:Piperidines; D011247:Pregnancy; D011256:Pregnancy Outcome; D000077208:Remifentanil
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D010880:Piperidines; D000077208:Remifentanil