Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia.
We describe a case of pediatric acute lymphoblastic leukemia (ALL) with trisomy 5 as a sole cytogenetic abnormality. A comparison is made with the two cases of adult acute lymphoblastic leukemia with trisomy 5 in the literature. This rare cytogenetic abnormality may portend an especially poor prognosis in patients with ALL.
Sandoval
C
C
Department of Pediatrics, New York Medical College, Valhalla, NY 10595, USA.
Mayer
S P
SP
Ozkaynak
M F
MF
Tugal
O
O
Jayabose
S
S
D000328:Adult; D002648:Child; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor; D005803:Genes, Immunoglobulin / Q000235:genetics; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D014314:Trisomy / Q000235:genetics*