Testicular peritubular myoid cells are a target for adrenomedullin.
Adrenomedullin (AM) is a recently cloned vasorelaxing peptide that belongs to the calcitonin gene-related peptide family. AM inhibits the contraction of several types of smooth muscle cells and is present in the testis as well as in many other organs. The authors investigated whether testicular peritubular myoid cells (PMC) possess specific receptors for AM. Binding of AM to PMC was saturable in a time-dependent manner and 125I-AM binding was effectively displaced by cold AM. The study documents that testicular peritubular myoid cells are a target for adrenomedullin and suggests a role for this peptide in the paracrine regulation of the testis.
Rossi
F
F
Department of Medical Pathophysiology, La Sapienza University of Rome, Italy.
Guerrini
L
L
Pasimeni
G
G
Markouizou
A
A
Fabbrini
A
A
Santiemma
V
V
D053607:Adrenomedullin; D000818:Animals; D002478:Cells, Cultured; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D058265:Receptors, Adrenomedullin; D018000:Receptors, Peptide; D012671:Seminiferous Tubules / Q000166:cytology / Q000502:physiology; D013737:Testis / Q000166:cytology / Q000378:metabolism*; D014665:Vasodilator Agents / Q000378:metabolism*
D008565:Membrane Proteins; D010455:Peptides; D058265:Receptors, Adrenomedullin; D018000:Receptors, Peptide; D014665:Vasodilator Agents; D053607:Adrenomedullin