[Detection of MLL gene rearrangement in acute myelomonocytic and monocytic leukemia].
OBJECTIVE
To reveal the incidence of MLL gene rearrangement and its clinical, features in acute myelomonocytic leukemia (M4) and acute monocytic leukemia (M5).


METHODS
10 patients with M4 and 27 cases with M5 were studied with the Southern blot technique to detect MLL gene abnormalities.


RESULTS
5 M5 patients were found to have MLL rearrangement, and these patients were characterized clinically by: (1) Younger at onset, (2) a higher white blood cell count (often > 100 x 10(9)/L), (3) frequent extramedullary involvement with hepatosplenomegaly and central nervous system leukemia (CNSL), and (4) a lower remission rate with a short survival time.


CONCLUSIONS
There is a high incidence of MLL rearrangement in M5, and this gene abnormality stands for a marker of poor prognosis.
Ma
Z
Z
Xin Hua Hospital, Shanghai Second Medical University.
Dong
D
D
Cao
Q
Q
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007223:Infant; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D011379:Prognosis