[Oral contraceptives and activated protein C resistance: a paradigmatic example of genotype and environment interaction in the development of deep venous thrombosis].
A young woman, carrying factor V Leiden, developed a deep venous thrombosis after the use of oral contraceptives. This suggests that it is appropriate to study the most frequent causes of primary thrombophilia in all of the women beginning a treatment with estrogens.
Panzini
E
E
Divisione di Medicina Interna, Ospedale A. Angelucci, Subiaco, Italia.
Raffa
S
S
Miconi
R
R
Lozzi
A
A
Marci
M
M
D020016:Activated Protein C Resistance / Q000150:complications*; D000328:Adult; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004487:Edema / Q000209:etiology; D005165:Factor V; D005260:Female; D006801:Humans; D020246:Venous Thrombosis / Q000097:blood / Q000139:chemically induced / Q000209:etiology*
D003276:Contraceptives, Oral; C095381:factor V Leiden; D005165:Factor V