title: Cyclin E overexpression in transitional cell carcinoma of the bladder.
abstract: We attempted to clarify the relationship between cyclin E to p27(Kip1), Ki-67 and clinicopathologic features in transitional cell bladder carcinoma. Immunohistochemical staining of archival tissue specimens of transitional cell bladder carcinoma obtained from 94 patients was performed by the labeled streptavidin-biotin-peroxidase method. Overexpression of cyclin E protein was observed in 38 of the 94 (40.4%) specimens, and was positively correlated with histological grade, Ki-67 LI and p27(Kip1) labeling index (LI). These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27(Kip1) for the regulation of cell cycle progression in transitional cell bladder carcinoma.
authors.affiliation: Department of Urology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa-ken, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Makiyama
authors.forename: M
authors.initials: M
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Takano
authors.forename: M
authors.initials: M
authors.lastname: Iki
authors.forename: T
authors.initials: T
authors.lastname: Asakura
authors.forename: Y
authors.initials: Y
authors.lastname: Suwa
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Hosaka
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000473:pathology*; D018797:Cell Cycle Proteins; D019927:Cyclin E / Q000032:analysis*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008869:Microtubule-Associated Proteins / Q000032:analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D025521:Tumor Suppressor Proteins; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000473:pathology*
chemical_list: D018797:Cell Cycle Proteins; D019927:Cyclin E; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27