[QT interval dispersion and the type of obesity in women].
The risk of sudden cardiac death is higher in patients with obesity, particularly in the upper body obesity. The most common cause of cardiac events are serious ventricular arrhythmias. Delayed cardiac repolarization leading to the prolongation of the QT interval is a well characterised precursor of arrhythmias. The QT interval dispersion reflects inhomogeneity of repolarization. The aim of this study was to assess QT interval dispersion (QTd) in obese women and to establish the relationship between obesity and QTd. 62 patients with obesity (group 1) and 15 apparently healthy women (group 2) were included in our study. Obese subjects were distinguished in accordance to the waist to hip ratio (WHR) into three subgroups: 1a--obese women with upper body obesity; 1b--obese women with WHR: 0.75-0.85; 1c--obese women with lower body obesity. A standard 12-lead ECG was performed in each subjects and QTd, QTdc (QT correlated interval dispersion), QTdR (QTd ratio) were calculated. The left ventricular mass (LVM) and left ventricular mass index (LVMI) were obtained from echocardiograms. We found QTd, QTdc, QTdR and LVM, LVMI to be significantly higher in obese women as well as positive correlation between BMI and both LVM, LVMI. QTdR was significantly higher in subgroup 1a compared with subgroup 1c.


CONCLUSIONS
1) QT interval dispersion was increased in obese women compared with healthy subjects, 2) supposedly increased QTd was associated with the type of obesity.
Mizia-Stec
K
K
II Klinika Kardiologii Sl. AM w Katowicach.
Mandecki
T
T
Zahorska-Markiewicz
B
B
Szulc
A
A
Jastrzebska-Maj
E
E
Szymański
L
L
D000273:Adipose Tissue / Q000503:physiopathology*; D000328:Adult; D000886:Anthropometry; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis / Q000503:physiopathology*; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D016277:Ventricular Function, Left