Linkage analysis for blood pressure with rat chromosome 15 markers.
A series of markers located across rat chromosome (Chr.) 15 was mapped and then systematically genotyped for cosegregation with blood pressure in an F2 population that originated from crosses of the Dahl salt-sensitive (S) rats with rats of the Wistar-Kyoto (WKY) strain, i.e., F2(S x WKY). Alleles for the markers centered around the locus for endothelin-receptor B (Ednrb) weakly cosegregated with blood pressure in the F2(S x WKY) population. Therefore, it appears highly unlikely that there is major blood pressure quantitative trait locus (QTL) on rat Chr. 15, which possesses a strong effect on blood pressure in the S rat. The Chr. 15 map will be useful for mapping genes and searching for QTL of other biological traits.
Deng
A Y
AY
Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614-5804, USA. adeng@vortex.mco.edu
D000818:Animals; D001483:Base Sequence; D001794:Blood Pressure / Q000235:genetics*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D017931:DNA Primers / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D008297:Male; D019655:Quantitative Trait, Heritable; D051381:Rats; D020303:Rats, Inbred Dahl; D011921:Rats, Inbred WKY
D017931:DNA Primers; D005819:Genetic Markers