Rapid change of platelet aggregability in acute hyperglycemia. Detection by a novel laser-light scattering method.
We examined the alteration of platelet aggregability in acute hyperglycemia during 75-gram oral glucose tolerance tests (OGTT). Twenty subjects underwent 75-gram OGTT and venous blood samples were obtained before (0 min), 60, 120 and 180 min postload. Platelet aggregability shown as the number of small platelet aggregates was measured with a novel laser-light scattering (LS) method. Platelet aggregability increased in parallel with both glucose and immunoreactive insulin (IRI) levels. The number of mean small aggregates at 60 min (12.30 +/- 1.10 X 10(4)) was significantly higher than the one at 0 min (8.32 +/- 0.88 x 10(4), p <0.001), 120 min (10.63 +/- 0.98 x 10(4), p <0.05) and 180 min (8.28 +/- 0.84 x 104, p <0.001) (mean +/- SEM). Small aggregates correlated positively with plasma glucose levels at 60 min postload (r = 0.67, p = 0.001) while not with IRI. It might be important to suppress transient hyperglycemia for preventing the onset of acute coronary syndromes that could be closely related to platelet hyperaggregability.
Sakamoto
T
T
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Japan.
Ogawa
H
H
Kawano
H
H
Hirai
N
N
Miyamoto
S
S
Takazoe
K
K
Soejima
H
H
Kugiyama
K
K
Yoshimura
M
M
Yasue
H
H
D000208:Acute Disease; D000244:Adenosine Diphosphate / Q000494:pharmacology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D066298:In Vitro Techniques; D007834:Lasers; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D012542:Scattering, Radiation
D000244:Adenosine Diphosphate