Gene therapy: designer promoters for tumour targeting.
One of the biggest challenges facing cancer therapy is to generate tumour-specific treatment strategies. Gene therapy hopes to achieve this by directing the activity of therapeutic genes specifically to the sites of disease. Of paramount importance for the success of this approach is the availability of tumour-specific delivery systems: both the transductional targeting of the vector vehicle and the restriction of transgene expression to the tumour are promising strategies towards this goal. This review will focus on the recent achievements in the field of transcriptional targeting and the different strategies to improve or design promoters with the desired specificities.
Nettelbeck
D M
DM
Institute of Molecular Biology and Tumor Research (IMT), Philipps-University Marburg, Emil-Mannkopff-Strasse 2, D-35033 Marburg, Germany. nettelbeck@imt.uni-marburg.de
Jérôme
V
V
Müller
R
R
D000818:Animals; D002453:Cell Cycle; D004730:Endothelium, Vascular; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic; D014779:Virus Replication