title: Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants.
abstract: BACKGROUND
  Lung injury after cardiopulmonary bypass is a serious complication for infants with congenital heart disease and pulmonary hypertension. Excessive neutrophil sequestration in the lung occurring after reestablishment of pulmonary circulation implies that interaction between neutrophils and pulmonary endothelium is the major cause of lung injury.
  
  
  METHODS
  Thirty infants with either ventricular septal defect or atrioventricular septal defect and with pulmonary hypertension were enrolled in this study. We performed continuous pulmonary perfusion during total cardiopulmonary bypass on 16 patients (perfused group) and conventional cardiopulmonary bypass on 14 patients (control group). PaO2/FiO2 and neutrophil counts were assessed from immediately before surgery to 24 hours after termination of cardiopulmonary bypass.
  
  
  RESULTS
  PaO2/FiO2 was higher in the perfused group than in the control group, and the difference was significant throughout the study period. Neutrophil counts decreased below prebypass values in both groups at 30 minutes after aortic unclamping, and the difference was significant in the control group but was not in the perfused group. Duration of postoperative ventilatory support was significantly less in the perfused group.
  
  
  CONCLUSIONS
  Our study demonstrates that arrested pulmonary circulation during cardiopulmonary bypass is the major risk factor of lung injury and that continuous pulmonary perfusion is effective in preventing lung injury.
authors.affiliation: Division of Cardiovascular Surgery, Tokyo Metropolitan Children's Hospital, Japan. suzuki@chp.kiyose.tokyo.jp
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: Y
authors.initials: Y
authors.lastname: Cho
authors.forename: I
authors.initials: I
authors.lastname: Kashima
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006801:Humans; D007223:Infant; D010477:Perfusion / Q000379:methods*; D015427:Reperfusion Injury / Q000517:prevention & control*; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000517:prevention & control