Congenital malformations after intracytoplasmic injection of spermatids.
Spermatid microinjection into oocytes was applied in cases of intracytoplasmic sperm injection (ICSI)/testicular sperm extraction (TESE) where no spermatozoa could be found in numerous testicular samples. Although several pregnancies were obtained with this procedure, serious concerns remain regarding its safety. Although the relevance of the injection of spermatids is by no means certain, we wish to report that from four pregnancies obtained after injection of elongated spermatids, two cases of major malformation resulted.
Zech
H
H
Institut für Reproduktionsmedizin und Endokrinologie, Bregenz, Austria.
Vanderzwalmen
P
P
Prapas
Y
Y
Lejeune
B
B
Duba
E
E
Schoysman
R
R
D000328:Adult; D001139:Arnold-Chiari Malformation / Q000209:etiology; D002899:Chromosomes, Human, Pair 9; D000013:Congenital Abnormalities / Q000209:etiology*; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects*; D013087:Spermatids; D016135:Spinal Dysraphism / Q000209:etiology; D014314:Trisomy