title: [Heat stroke: pathophysiology and pathogenesis].
abstract: The pathophysiology of heat stroke is not fully understood. Endotoxins and cytokines appear to play a major part in the central nervous system and in the peripheral tissues. Use of specific receptor blockers prior to heat exposure can diminish cerebral damage in animal experiments. The energy depletion model of Hubbard gives a possible explanation for the rhabdomyolysis observed in some heat stroke patients. Failure of the ATP dependent Na(+)-K+ pump is essential in this theory.
authors.affiliation: Afd. Algemene Interne Geneeskunde, Leids Universitair Medisch Centrum, Leiden.
authors.forename: M
authors.initials: M
authors.lastname: Emonts
authors.forename: A E
authors.initials: AE
authors.lastname: Meinders
mesh_terms: D058186:Acute Kidney Injury / Q000503:physiopathology; D018883:Heat Stroke / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D017114:Liver Failure, Acute / Q000503:physiopathology; D008954:Models, Biological; D009102:Multiple Organ Failure / Q000503:physiopathology; D005082:Physical Exertion; D012206:Rhabdomyolysis / Q000503:physiopathology; D000254:Sodium-Potassium-Exchanging ATPase
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase