title: Arthrogryposis multiplex congenita and bilateral mid-brain infarction following maternal overdose of co-proxamol.
abstract: We report a case of arthrogryposis multiplex congenita secondary to fetal hypokinesia in a 41-week gestation infant following antenatal central nervous system injury. The mother's pregnancy was complicated by an episode of attempted self harm, with an overdose of co-proxamol at 22 weeks of gestational age, and by the use of cocaine in combination with excess alcohol intake. Magnetic resonance imaging showed bilateral mid-brain cysts and marked atrophy of the basal ganglia and thalami.
authors.affiliation: Department of Paediatrics and Neonatal Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK.
authors.forename: E F
authors.initials: EF
authors.lastname: Maalouf
authors.forename: M
authors.initials: M
authors.lastname: Battin
authors.forename: S J
authors.initials: SJ
authors.lastname: Counsell
authors.forename: M A
authors.initials: MA
authors.lastname: Rutherford
authors.forename: A Y
authors.initials: AY
authors.lastname: Manzur
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D001176:Arthrogryposis / Q000139:chemically induced* / Q000175:diagnosis; D001921:Brain / Q000473:pathology; D001925:Brain Damage, Chronic / Q000139:chemically induced / Q000175:diagnosis; D019970:Cocaine-Related Disorders / Q000175:diagnosis; D011431:Dextropropoxyphene / Q000506:poisoning*; D004338:Drug Combinations; D062787:Drug Overdose / Q000175:diagnosis*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000175:diagnosis; D005324:Fetal Movement / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D013406:Suicide, Attempted
chemical_list: D004338:Drug Combinations; D000082:Acetaminophen; C011800:acetaminophen, dextropropoxyphene, drug combination; D011431:Dextropropoxyphene