title: Evaluation of antimicrobial treatment in mechanically ventilated patients with severe chronic obstructive pulmonary disease exacerbations.
abstract: OBJECTIVE
  To study microbial and susceptibility patterns and antimicrobial treatment responses in patients with severe, acute exacerbations of chronic obstructive pulmonary disease requiring mechanical ventilation.
  
  
  METHODS
  Microbial investigation using tracheobronchial aspirates, bronchoscopy with a protected specimen brush, and bronchoalveolar lavage, as well as paired serologies. Evaluation of antimicrobial treatment by results of the initial investigation, susceptibility testing, and a repeated microbial investigation (tracheobronchial aspirates, bronchoscopy with a protected specimen brush, and bronchoalveolar lavage) after 72 hrs.
  
  
  METHODS
  A respiratory intensive care unit of a 1,000-bed teaching hospital.
  
  
  METHODS
  Fifty severely exacerbated and mechanically ventilated patients with chronic obstructive pulmonary disease.
  
  
  METHODS
  Initial empirical antimicrobial treatment according to clinical judgment.
  
  
  RESULTS
  Overall, 36 of 50 patients (72%) had evidence of a microbial origin. Community-acquired endogenous pathogens were present in 70% of patients, and Gram-negative enteric bacilli and Pseudomonas/Stenotrophomonas species were present in 30%. All five isolates of Streptococcus pneumoniae were resistant to penicillin (three intermediately and two highly), and three were resistant to multiple antibiotics. Pseudomonas species revealed multiresistance in four of nine isolates (44%), and Stenotrophomonas maltophilia revealed multiresistance in one of two isolates. Antimicrobial treatment was modified according to diagnostic results in 11 of 31 patients (36%) with potentially pathogenic microorganisms. In patients who underwent a repeat investigation after 72 hrs, 24% of the initially present and potentially pathogenic microorganisms persisted. Inappropriate initial antimicrobial therapy was associated significantly with bacterial persistence (p < .002).
  
  
  CONCLUSIONS
  Considering the diversity of microbial pathogens and the resistance rates especially to S. pneumoniae in this patient population, antimicrobial treatment should be based on the constant study of local microbial and susceptibility patterns along with routine microbial investigation of the individual patient.
authors.affiliation: Servei de Pneumologia i Allergia Respiratoria, Hospital Clinic, Universitat de Barcelona, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Ewig
authors.forename: N
authors.initials: N
authors.lastname: Soler
authors.forename: J
authors.initials: J
authors.lastname: Gonzalez
authors.forename: R
authors.initials: R
authors.lastname: Celis
authors.forename: M
authors.initials: M
authors.lastname: El-Ebiary
authors.forename: A
authors.initials: A
authors.lastname: Torres
mesh_terms: D000368:Aged; D019072:Antibiotic Prophylaxis / Q000379:methods; D001424:Bacterial Infections / Q000150:complications / Q000382:microbiology / Q000517:prevention & control*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D001999:Bronchoscopy; D015169:Colony Count, Microbial; D017714:Community-Acquired Infections / Q000150:complications / Q000382:microbiology / Q000517:prevention & control; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000382:microbiology*; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial; D016896:Treatment Outcome