[Human herpesvirus 6(HHV-6) and HHV-8 in malignant lymphoma].
Over the past 14 years three new human herpesviruses(HHV-6, -7 and -8) have been recognized and implicated as etiological agents of several human diseases. HHV-6 has been cited as a possible cause or as a modulating element of certain human lymphoproliferative disorders, particularly malignant lymphomas including Hodgkin's disease and Burkitt's lymphoma. Despite the genomic homology and serological cross-reactivity between HHV-6 and HHV-7, evidence for the association of HHV-7 with lymphoproliferative diseases has been scarce. HHV-8 was originally found in patients with Kaposi's sarcoma, and subsequently shown to be implicated in primary effusion lymphoma(PEL), a novel lymphoma entity. We found that HHV-6 genome is integrated into host DNA of lymphoma cells. Further studies are warranted to determine whether chromosomally integrated HHV-6 has any role in the pathogenesis of viral genome-positive lymphoproliferative diseases.
Daibata
M
M
Third Department of Medicine, Kochi Medical School.
D004247:DNA; D016679:Genome, Viral; D015654:Herpesvirus 6, Human / Q000472:pathogenicity; D019288:Herpesvirus 8, Human / Q000472:pathogenicity; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000821:virology; D016662:Virus Integration
D004247:DNA