[Chronobiological characteristics of renal function under conditions of T4- and T3-hyperthyreosis].
Hyperthyreosis in rats after 10 days of injecting T4 at the dose of 100 mg/kg of the body mass modified the chronostructure of renal functions by decreasing rhythms of the urinal pH mesor, and elevating rhythms of creatinine and protein excretion mesors, and the mesor and the amplitude of sodiuresis rhythms. Temporal readjustment of renal functions reflects peculiarities of the body adaptation to T4-induced hyperthyreosis. Injections of T3 (20 mg/kg of the body mass) during 10 days do not lead to any significant changes in the biorhythmic properties of the renal functions.
Pishak
V P
VP
Dolomatov
S I
SI
Klykov
O V
OV
Cherevko
I M
IM
D000818:Animals; D002940:Circadian Rhythm; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology*; D007677:Kidney Function Tests; D008297:Male; D051381:Rats; D013974:Thyroxine / Q000633:toxicity*; D014284:Triiodothyronine / Q000633:toxicity*
D014284:Triiodothyronine; D013974:Thyroxine