Prednisolone-induced alteration in hepatic and muscular protein and glycogen level: its correlation with blood glucose level in mice.
Prednisolone, a potent glucocorticoid, is well known for its immunosuppressive effects on animals. A single dose of 100 microg, 200 microg and 300 microg prednisolone/kg body weight was administered in Swiss albino male mice. Seven days after treatment, the animals were sacrificed to investigate the effect of prednisolone on hepatic and muscular protein contents and glycogen levels along with the level of blood glucose. A catabolic effect on the protein level was evidenced but at the same time the mice became hypoglycemic.
Karmakar
R
R
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Ghatak
S
S
Haider
A
A
Bhattacharya
S
S
Kundu
S N
SN
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
D001786:Blood Glucose; D005938:Glucocorticoids; D008112:Liver Glycogen; D009124:Muscle Proteins; D011506:Proteins; D006003:Glycogen; D011239:Prednisolone