Novel peak assignments of in vivo (13)C MRS in human brain at 1.5 T.
(13)C MRS studies at natural abundance and after intravenous 1-(13)C glucose infusion were performed on a 1.5-T clinical scanner in four subjects. Localization to the occipital cortex was achieved by a surface coil. In natural abundance spectra glucose C(3beta,5beta), myo-inositol, glutamate C(1,2,5), glutamine C(1,2,5), N-acetyl-aspartate C(1-4,C=O), creatine CH(2), CH(3), and C(C=N), taurine C(2,3), bicarbonate HCO(-)(3) were identified. After glucose infusion (13)C enrichment of glucose C(1alpha,1beta), glutamate C(1-4), glutamine C(1-4), aspartate C(2,3), N-acetyl-aspartate C(2,3), lactate C(3), alanine C(3), and HCO(-)(3) were observed. The observation of (13)C enrichment of resonances resonating at >150 ppm is an extension of previously published studies and will provide a more precise determination of metabolic rates and substrate decarboxylation in human brain.
Blüml
S
S
Huntington Medical Research Institutes, Pasadena, California 91105, USA.
Hwang
J H
JH
Moreno
A
A
Ross
B D
BD
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002247:Carbon Isotopes; D002675:Child, Preschool; D003401:Creatine / Q000378:metabolism; D003711:Demyelinating Diseases / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D007294:Inositol / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation; D008297:Male; D009778:Occipital Lobe / Q000378:metabolism; D013654:Taurine / Q000378:metabolism
D001639:Bicarbonates; D002247:Carbon Isotopes; D005973:Glutamine; D013654:Taurine; D001224:Aspartic Acid; D018698:Glutamic Acid; D007294:Inositol; C000179:N-acetylaspartate; D005947:Glucose; D003401:Creatine