Cyclin E overexpression in transitional cell carcinoma of the bladder.
We attempted to clarify the relationship between cyclin E to p27(Kip1), Ki-67 and clinicopathologic features in transitional cell bladder carcinoma. Immunohistochemical staining of archival tissue specimens of transitional cell bladder carcinoma obtained from 94 patients was performed by the labeled streptavidin-biotin-peroxidase method. Overexpression of cyclin E protein was observed in 38 of the 94 (40.4%) specimens, and was positively correlated with histological grade, Ki-67 LI and p27(Kip1) labeling index (LI). These data suggest that cyclin E may be associated with aggressive tumor growth, and may have a relationship with p27(Kip1) for the regulation of cell cycle progression in transitional cell bladder carcinoma.
Makiyama
K
K
Department of Urology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa-ken, Japan.
Masuda
M
M
Takano
Y
Y
Iki
M
M
Asakura
T
T
Suwa
Y
Y
Noguchi
S
S
Hosaka
M
M
D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000473:pathology*; D018797:Cell Cycle Proteins; D019927:Cyclin E / Q000032:analysis*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008869:Microtubule-Associated Proteins / Q000032:analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D025521:Tumor Suppressor Proteins; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000473:pathology*
D018797:Cell Cycle Proteins; D019927:Cyclin E; D019394:Ki-67 Antigen; D008869:Microtubule-Associated Proteins; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27