title: Solid phase synthesis of diamides as potential bone resorption inhibitors.
abstract: Unsymmetrical diamide libraries have been prepared by a general and versatile solid phase route, using diacid templates in combination with aromatic and aliphatic amines chosen with the help of statistical experimental design. The compounds were tested as potential inhibitors of osteoclast vacuolar ATPase.
authors.affiliation: Preclinical R&D, AstraZeneca R&D Mölndal, Sweden. karin.edvinsson@karobio.se
authors.forename: K M
authors.initials: KM
authors.lastname: Edvinsson
authors.forename: M
authors.initials: M
authors.lastname: Herslöf
authors.forename: P
authors.initials: P
authors.lastname: Holm
authors.forename: N
authors.initials: N
authors.lastname: Kann
authors.forename: D J
authors.initials: DJ
authors.lastname: Keeling
authors.forename: J P
authors.initials: JP
authors.lastname: Mattsson
authors.forename: B
authors.initials: B
authors.lastname: Nordén
authors.forename: V
authors.initials: V
authors.lastname: Shcherbukhin
mesh_terms: D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D001862:Bone Resorption / Q000188:drug therapy*; D002645:Chickens; D016208:Databases, Factual; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D010010:Osteoclasts / Q000187:drug effects / Q000201:enzymology; D013698:Templates, Genetic
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D000251:Adenosine Triphosphatases