title: Clustering of Brugia malayi infection in a community in South-Sulawesi, Indonesia.
abstract: The present study was undertaken in village Karondang in South-Sulawesi, Indonesia, to investigate the influences of genetic, household and environmental factors on Brugia malayi infection. Infection status was determined by measuring both microfilariae in night blood and anti-filarial IgG4, as a marker for detection of active filarial infection. A total of 171 residents participated in the study; familial relationships between subjects were registered to construct pedigrees and distances between households were measured. The data were analysed using a test statistic for familial aggregation. For distribution of microfilariae over the study population a genetic influence on infection susceptibility was favoured over the household and environmental effects. For anti-filarial IgG4, all 3 clustering models gave significant results, suggesting that genetic, household and/or environmental factors influence specific IgG4 antibodies.
authors.affiliation: Department of Parasitology, Leiden University Medical Centre, The Netherlands. A.J.Terhell@Parasitology.medfac.leidenuniv.nl
authors.forename: A J
authors.initials: AJ
authors.lastname: Terhell
authors.forename: J J
authors.initials: JJ
authors.lastname: Houwing-Duistermaat
authors.forename: Y
authors.initials: Y
authors.lastname: Ruiterman
authors.forename: M
authors.initials: M
authors.lastname: Haarbrink
authors.forename: K
authors.initials: K
authors.lastname: Abadi
authors.forename: M
authors.initials: M
authors.lastname: Yazdanbakhsh
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D017178:Brugia malayi / Q000276:immunology / Q000302:isolation & purification* / Q000472:pathogenicity; D002648:Child; D016000:Cluster Analysis; D004605:Elephantiasis, Filarial / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D008842:Microfilariae / Q000276:immunology; D008875:Middle Aged; D018512:Parasitemia; D010375:Pedigree; D015995:Prevalence; D018709:Statistics, Nonparametric
chemical_list: D000947:Antigens, Helminth; D007074:Immunoglobulin G