title: Cytotoxicity and antileishmanial activity of Annona muricata pericarp.
abstract: Hexane, ethyl acetate and methanol extracts of Annona muricata pericarp were tested in vitro against Leishmania braziliensis and L. panamensis promastigotes, and against cell line U-937. The ethyl acetate extract was more active than the other extracts and even of Glucantime used as reference substance. Its fractionation led to the isolation of three acetogenins--annonacin, annonacin A and annomuricin A.
authors.affiliation: Facultad de Química Farmacéutica, Universidad de Antioquia, A. A. 1226 Medellín, Colombia.
authors.forename: M C
authors.initials: MC
authors.lastname: Jaramillo
authors.forename: G J
authors.initials: GJ
authors.lastname: Arango
authors.forename: M C
authors.initials: MC
authors.lastname: González
authors.forename: S M
authors.initials: SM
authors.lastname: Robledo
authors.forename: I D
authors.initials: ID
authors.lastname: Velez
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line / Q000187:drug effects; D005663:Furans / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry; D007891:Leishmania / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal
chemical_list: D000981:Antiprotozoal Agents; D005663:Furans; D007783:Lactones; D010936:Plant Extracts; C095611:annomuricin A; C053442:annonacin; D015107:4-Butyrolactone