Effect of vitamin A therapy on serologic responses and viral load changes after influenza vaccination in children infected with the human immunodeficiency virus.
Vitamin A administered to children infected with the human immunodeficiency virus before influenza vaccination in a double-blind randomized study did not enhance vaccine serologic responses but did dampen the increase in the human immunodeficiency virus viral load 14 days after immunization (vitamin A, decrease of 0.13 +/- 0.09 log(10) copies/mL; placebo, increase of 0.14 +/- 0.08, P =.02).
Hanekom
W A
WA
Department of Pediatrics, Northwestern University Medical School, Chicago, IL, USA.
Yogev
R
R
Heald
L M
LM
Edwards
K M
KM
Hussey
G D
GD
Chadwick
E G
EG
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D015497:HIV-1; D006801:Humans; D009980:Influenza A virus / Q000276:immunology*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000276:immunology*; D008297:Male; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000276:immunology; D019562:Viral Load; D014801:Vitamin A / Q000008:administration & dosage*
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated; D014801:Vitamin A