title: Mismatch negativity: a tool for the assessment of stimuli discrimination in cochlear implant subjects.
abstract: OBJECTIVE
  The performance of cochlear implants varies among users. This variability may be due to the ability to process auditory information. The mismatch negativity should provide an index of discrimination in cochlear implantees (Kraus N, McGee T, Carrell T, Sharma A. Neurophysiologic bases of speech discrimination. Ear Hear. 1995;16:19-37). Our aim was to analyze MMN in cochlear implant (Digisonic) subjects to assess electrode discrimination and to study the relationship between MMN and speech performance.
  
  
  METHODS
  The mismatch was determined by stimulating three pairs of different electrodes. Two sessions were performed with both standard and deviant stimuli reversed. Speech recognition abilities were evaluated using 4 speech tests. The statistics included the results of 6 subjects. They indicated that MMN may be obtained when stimulating two different electrodes. A difference occurred between standard and deviant stimuli within a session but also when the response to the deviant stimulus was compared to the response of the same stimulus in a standard condition, validating the discrimination process. MMN latency was about 140 ms, and amplitude about -2.8 microV. No differences were shown with respect to electrode spacing. No relationship between MMN and speech performance was found. A clinical application of this method might be to assess the auditory processing of electrical stimuli in congenitally deaf subjects at the pre-implantation stage.
authors.affiliation: Centre de Recherche et d'Ingénierie des Sciences et Techniques de l'Audition et du Langage (CRISTAL), Université Paris 13, Hôpital Avicenne, Service ORL, 125 rue de Stalingrad, 93009, Bobigny, France. jocelynewable@netscape.net
authors.forename: J
authors.initials: J
authors.lastname: Wable
authors.forename: T
authors.initials: T
authors.lastname: van den Abbeele
authors.forename: S
authors.initials: S
authors.lastname: Gallégo
authors.forename: B
authors.initials: B
authors.lastname: Frachet
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001303:Auditory Cortex / Q000502:physiology; D003054:Cochlear Implants; D003638:Deafness / Q000503:physiopathology* / Q000628:therapy*; D004192:Discrimination, Psychological; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005583:Fourier Analysis; D006801:Humans; D008875:Middle Aged; D013060:Speech / Q000502:physiology; D013067:Speech Perception / Q000502:physiology