Erythromycin resistance in Streptococcus pyogenes in Italy.
In a prospective study of acute pharyngitis in Italian children, 69 (38.3%) of 180 isolates of Streptococcus pyogenes were resistant to macrolides. S. pyogenes was eradicated in 12 (63.1%) of 19 patients with erythromycin-resistant S. pyogenes treated with clarithromycin and in 22 (88%) of 25 patients with erythromycin-susceptible strains. The constitutive-resistant phenotype was correlated with failure of macrolide treatment.
Bassetti
M
M
Infectious Diseases Department, University of Genoa, G. Gaslini Children's Hospital, Genoa, Italy. mattba@tin.it
Manno
G
G
Collidà
A
A
Ferrando
A
A
Gatti
G
G
Ugolotti
E
E
Cruciani
M
M
Bassetti
D
D
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007558:Italy; D008826:Microbial Sensitivity Tests; D010612:Pharyngitis / Q000188:drug therapy* / Q000382:microbiology*; D010641:Phenotype; D011446:Prospective Studies; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D004917:Erythromycin; D017291:Clarithromycin