Intraindividual Comparison of F-18-Fluorodeoxyglucose and Tc-99m-Tetrofosmin in Planar Scintimammography and SPECT.
Since the comparative value of several nuclear medicine investigations for breast cancer has not been established, the rationale of this study was to examine the diagnostic performances of F-18-fluorodeoxyglucose (FDG) and Tc-99m-tetrofosmin both in single photon emission computed tomography (SPECT) and planar technique in an intraindividual comparative study.A total of 54 patients with suspected breast cancer (48 malignant and 9 benign lesions) was investigated by planar and SPECT imaging with both FDG and tetrofosmin within the last preoperative week. Pathohistological confirmation of the diagnosis was obtained in all patients.2 cm 81%/67%, 92%/67%, 75%/50%, and 75%/100%. Sensitivity was higher with FDG SPECT than with the other imaging modalities and significantly lower for tumors </=2 cm with all the techniques investigated. In 20 out of 21 patients with diverging scintigraphic findings, FDG SPECT was either true positive or true negative. In 15 patients with axillary lymph node metastases, sensitivities were 33%, 73%, 36%, and 50%, respectively.2 cm, if dedicated PET is not available.
Ivancevic
V
Clinic for Nuclear Medicine and Clinic for Surgery, University Hospital Charité, Humboldt University, Berlin, Germany
Wolter
A
Winzer
K
Aldinger
H
Müller
JM
Munz
DL