Recurrent anomalies of 6q25 in chondromyxoid fibroma.
Chondromyxoid fibroma is a rare benign bone tumor most commonly arising in the metaphysis of long bones in young adults. Histopathologically, chondromyxoid fibroma may be difficult to distinguish from other cartilaginous neoplasms. Recently, a pericentric inversion of chromosome 6 [inv(6)(p25q13)] has been proposed as a specific genetic marker for chondromyxoid fibroma. In this study, cytogenetic and spectral karyotypic analyses of 2 chondromyxoid fibroma cases showed clonal abnormalities of chromosome 6 but at a breakpoint on the long arm (q25) distal to that described in the pericentric inversion. These findings suggest that several distinct breakpoints on chromosome 6 are nonrandomly involved in chondromyxoid fibroma.
Safar
A
A
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135, USA.
Nelson
M
M
Neff
J R
JR
Maale
G E
GE
Bayani
J
J
Squire
J
J
Bridge
J A
JA
D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D002804:Chondroblastoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008875:Middle Aged; D011859:Radiography; D012008:Recurrence; D013977:Tibia / Q000000981:diagnostic imaging; D014178:Translocation, Genetic