title: [Lyell's syndrome and its ophthalmologic manifestations in Cameroon].
abstract: BACKGROUND
  To study basic epidemiological datas and ocular involvment during toxic epidermal necrolysis (T.E.N.) in Cameroonian patients.
  
  
  METHODS
  Ten consecutive patients in the Central Hospital of Yaounde were included during a 4 years period. Anamnesis, clinical features, dermatological, ophthalmological and pathological examinations were done. Minimal follow up of 3 months.
  
  
  RESULTS
  Mean age: 20.1 +/- 11.4 yrs (SD); culprit drugs: sulfadoxin (5/10), sulfamethoxazol (3/10); phenytoin (1/10). Mean of skin detachment: 41 +/- 17%. 2 patients died with sulfadoxin as culprit drug. Early ocular findings: conjunctivitis (all patients), symblepharon (1/8), ankyloblepharon (3 patients over 8 with sulfadoxin as culprit drug). All cases with ankyloblepharon (3) evoluated toward formation of a fibrovascular precorneal membrane with blindness. Two of the patients received a kerothoprosthesis on one eye. The 3 patients had a severe dry eye syndrome.
  
  
  CONCLUSIONS
  TEN appears to be uncommon in Cameroon. Use of sulfonamides for treatment and prevention of malaria and AID'S opportunistic infections may increase the incidence of disease in tropical african areas. Ophthalmologists should be aware of early management of ocular manifestations in Lyell syndrome to avoid severe sequelae. That sequelae may be due to usual intensive healing in African patients. Severe corneal damages can be corrected only by keratoprosthesis.
authors.affiliation: Faculté de Médecine et des Sciences Biomédicales, Université de Yaoundé, I. Yaoundé, Cameroun.
authors.forename: M
authors.initials: M
authors.lastname: Moussala
authors.forename: F
authors.initials: F
authors.lastname: Beharcohen
authors.forename: P
authors.initials: P
authors.lastname: Dighiero
authors.forename: G
authors.initials: G
authors.lastname: Renard
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D001766:Blindness / Q000139:chemically induced; D002163:Cameroon; D002648:Child; D002675:Child, Preschool; D003229:Conjunctival Diseases / Q000139:chemically induced; D003231:Conjunctivitis / Q000209:etiology; D015352:Dry Eye Syndromes / Q000139:chemically induced; D005128:Eye Diseases / Q000139:chemically induced*; D005141:Eyelid Diseases / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects; D013262:Stevens-Johnson Syndrome / Q000150:complications* / Q000209:etiology; D013413:Sulfadoxine / Q000009:adverse effects; D013420:Sulfamethoxazole / Q000009:adverse effects; D013997:Time Factors; D000267:Tissue Adhesions / Q000139:chemically induced
chemical_list: D000890:Anti-Infective Agents; D000927:Anticonvulsants; D010672:Phenytoin; D013413:Sulfadoxine; D013420:Sulfamethoxazole