[Mechanism of protective action of Phyllanthus urinaria L. against injuries of liver cells].
It has been found out that the carbon tetrachloride (CCl4)-induced increase of serum glutamic-pyruvic transaminase (ALT) and elevation of MDA in liver of mice are significantly lowered by Phyllanthus urinaria in vivo, and the coincubation of isolated rat hepatocytes with Phyllanthus urinaria in vitro significantly inhibits CCl4-induced decrease of mobility of membrane of liver cells and increase of intracellular free Ca2+ ([Ca2+]i) concentrations of liver cells. These results suggest that the anti-lipid peroxidation effect and protective action of membrane of Phyllanthus urinaria may be related to its protective action against CCl4-induced liver injuries.
Zhou
S
S
Department of Clinical Pharmacology, Second Affiliated Hospital, Third Military Medical University, Chongqing.
Xu
C
C
Zhou
N
N
Huang
Y
Y
Huang
L
L
Chen
X
X
Hu
Y
Y
Liao
Y
Y
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D019665:Euphorbiaceae; D005260:Female; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects; D051379:Mice; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D000410:Alanine Transaminase