Biosynthesis of vitamin B(6) in rhizobium.
The biosynthetic pathway of pyridoxol (vitamin B(6)) in Rhizobium was clarified by studies on the incorporation of (13)C- or (15)N-labeled precursors into pyridoxol or its biosynthetic intermediates. Pyridoxol was formed by ring closure of two compounds, 1-deoxy-D-xylulose and 4-hydroxy-L-threonine. The former was formed from D-glyceraldehyde and pyruvate through decarboxylation of pyruvate, and the latter from glycine and glycolaldehyde.
Tazoe
M
M
Department of Applied Microbiology, Nippon Roche Research Center, Kamakura, Kanagawa 247-8530, Japan. masaaki.tazoe@roche.com
Ichikawa
K
K
Hoshino
T
T
D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011736:Pyridoxine / Q000096:biosynthesis*; D012231:Rhizobium / Q000378:metabolism*
D011736:Pyridoxine