The number of CD34+ cells mobilized into the peripheral blood can predict the quality of subsequent collections.
PBPC were mobilized using a variety of chemotherapy regimens plus G-CSF in a group of 126 consecutive patients. Data are presented that show a close correlation between the number of CD34+ cells mobilized into the peripheral blood (PB) and the number of CD34+ cells subsequently collected by leukapheresis (R = 0.904). On the basis of this correlation, a regression formula was calculated that could give an estimate of the total number of CD34+ cells likely to be collected by leukapheresis from a given number of CD34+ cells per microliter PB. An easy-to-read table has been compiled to show how this type of analysis can be applied to predict the likely dose of CD34+ cells that will be obtained by leukapheresis over a wide range of patient weights.
Alcorn
M J
MJ
Department of Haematology, Glasgow Royal Infirmary University NHS Trust, UK.
Farrell
E
E
Barr
J
J
Pearson
C
C
Green
R
R
Holyoake
T
T
D018952:Antigens, CD34 / Q000097:blood*; D001835:Body Weight; D002985:Clinical Protocols; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007937:Leukapheresis / Q000592:standards*; D011786:Quality Control; D012189:Retrospective Studies
D018952:Antigens, CD34