Angiogenic growth factors: potential new treatment for acute myocardial infarction?
In models of hind-limb ischemia and progressive coronary artery occlusion, angiogenic growth factor proteins and genes expressing growth factors have been shown to induce the development of collateral vessels and remodeling of existing collaterals. The therapeutic potential of growth factors in the setting of acute myocardial infarction may be related to non-angiogenic properties of growth factors as well, and is the focus of this review.
Gonçalves
L M
LM
Cardiology Department, Coimbra University Hospital, Portugal. lgoncalv@ci.uc.pt
D000818:Animals; D003097:Collateral Circulation; D005346:Fibroblast Growth Factors / Q000627:therapeutic use; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D013002:Somatomedins / Q000627:therapeutic use
D006133:Growth Substances; D013002:Somatomedins; D005346:Fibroblast Growth Factors