Hyperpolarized 129Xe NMR as a probe for blood oxygenation.
Optically enhanced NMR with (129)Xe and (3)He is emerging as a novel and promising technique for medical imaging of lungs and other tissues. Here it is shown that hyperpolarized (129)Xe NMR provides a powerful means of measuring blood oxygenation quantitatively and noninvasively. The interaction of xenon with hemoglobin is responsible for an oxygen-dependent NMR shift of (129)Xe in red blood cells, in sharp contrast to the current model of xenon-hemoglobin binding. This effect could be exploited in brain functional studies, and in the assessment of conditions and diseases affected by blood oxygenation.
Wolber
J
J
CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research, The Royal Marsden NHS Trust, Sutton, Surrey, UK.
Cherubini
A
A
Leach
M O
MO
Bifone
A
A
D006801:Humans; D007089:Image Enhancement / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D055095:Optics and Photonics; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D012680:Sensitivity and Specificity; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D010100:Oxygen