title: Cycloaromatization and DNA cleavage of novel non-conjugated aromatic enetetrayne systems.
abstract: The novel, non-conjugated aromatic enetetrayne (2) underwent thermal cycloaromatization reaction to give polyphenylene derivative 6, forming a methyl cation as an active intermediate, and showed DNA-cleaving activity.
authors.affiliation: Institute of Scientific and Industrial Research, Osaka University, Japan. ueda@sanken.osaka-u.ac.jp
authors.forename: I
authors.initials: I
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Miyawaki
authors.forename: T
authors.initials: T
authors.lastname: Sugane
authors.forename: Y
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
authors.forename: M
authors.initials: M
authors.lastname: Futai
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D004249:DNA Damage / Q000187:drug effects*; D004278:DNA, Superhelical / Q000187:drug effects; D006358:Hot Temperature; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000480:Alkynes; D004278:DNA, Superhelical; D006841:Hydrocarbons, Aromatic