Decatromicins A and B, new antibiotics produced by Actinomadura sp. MK73-NF4. I. Taxonomy, isolation, physico-chemical properties and biological activities.
New antibiotics designated decatromicins A and B were isolated from the culture broth of Actinomadura sp. MK73-NF4. They were purified by butyl acetate extraction, silica gel column chromatography, silica gel TLC and Sephadex LH-20 column chromatography. Decatromicins A and B inhibited growth of Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA).
Momose
I
I
Institute of Microbial Chemistry, Tokyo, Japan.
Iinuma
H
H
Kinoshita
N
N
Momose
Y
Y
Kunimoto
S
S
Hamada
M
M
Takeuchi
T
T
D000192:Actinomycetales / Q000145:classification* / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice
D000900:Anti-Bacterial Agents; D018942:Macrolides; C405842:decatromicin A; C405843:decatromicin B