Integrins: the molecular glue of life.
The molecular interactions responsible for cellular adhesion, either to other cells or to extracellular matrix, are now known to be complex, well orchestrated, and under sophisticated control. Among the participating molecules, integrins serve a notably broad range of biologic processes, including platelet aggregation and leukocyte extravasation. The loss of an adhesion interaction may result in disease, as may the stimulation of excessive adhesiveness.
Etzioni
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Division of Pediatrics, Rambam Medical Center-B. Rappaport School of Medicine, Haifa, Israel.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002448:Cell Adhesion; D004195:Disease Models, Animal; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000502:physiology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000235:genetics / Q000628:therapy; D051379:Mice; D018345:Mice, Knockout; D011817:Rabbits; D013915:Thrombasthenia / Q000235:genetics
D000911:Antibodies, Monoclonal; D016023:Integrins