title: Distress in MEN 2 family members and partners prior to DNA test disclosure. Multiple endocrine neoplasia type 2.
abstract: Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant early-onset cancer disorder. In the Netherlands presymptomatic genetic testing for MEN 2 is offered to testees from the age of five years. We report on adults requesting testing for themselves (n=90) and on parents who want an at-risk child to be tested (n=26). Sociodemographic, personality, and attitude characteristics, and levels of psychological distress, were determined for applicants and their partners in the predisclosure phase of testing. These participants showed only mildly increased levels of psychological distress, defined as heightened scores on measures of general and test-related anxiety, and of psychological complaints. Compared with a normal population, high levels of anxiety and health complaints were found in applicants who were younger than 25 years and single, and in persons who generally tended to react to distressful situations with anxiety or depression. These characteristics were particularly evident in young applicants (<25 years). Our study shows that people who feel ambivalent towards DNA testing and who are more vulnerable to psychological distress are more likely to agree to participate in the test as part of a collective application by members of a hereditary cancer family.
authors.affiliation: Department of Medical Psychology, University Medical Center, Utrecht, The Netherlands. f.j.m.grosfeld@med.uu.nl
authors.forename: F J
authors.initials: FJ
authors.lastname: Grosfeld
authors.forename: C J
authors.initials: CJ
authors.lastname: Lips
authors.forename: F A
authors.initials: FA
authors.lastname: Beemer
authors.forename: G H
authors.initials: GH
authors.lastname: Blijham
authors.forename: J M
authors.initials: JM
authors.lastname: Quirijnen
authors.forename: M P
authors.initials: MP
authors.lastname: Mastenbroek
authors.forename: H F
authors.initials: HF
authors.lastname: ten Kroode
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001007:Anxiety; D001294:Attitude to Health; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000032:analysis* / Q000235:genetics; D005190:Family / Q000523:psychology; D005192:Family Health; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D018813:Multiple Endocrine Neoplasia Type 2a / Q000175:diagnosis / Q000235:genetics / Q000523:psychology*; D010353:Patient Education as Topic; D010551:Personality; D012923:Social Class; D013315:Stress, Psychological
chemical_list: D004247:DNA