The effects of sodium ampicillin, sodium cefazolin, and sodium cefoxitin on blood pressures and heart rates in healthy, anesthetized dogs.
This study determined the effects of intravenous ampicillin, cefazolin, and cefoxitin on blood pressures and heart rates in healthy, anesthetized dogs. Forty dogs were each randomly assigned to a control, ampicillin, cefazolin, or cefoxitin group. Antibiotics or saline was delivered by intravenous bolus prior to surgical stimulation. Heart rate; systolic, mean, and diastolic arterial pressures; oxygen saturation; end-tidal halothane; and end-tidal carbon dioxide (CO2) were recorded before and every minute for 10 minutes after the test drug was administered. No significant differences were recorded between the antibiotic and control groups. The prophylactic use of these antibiotics should be considered safe in healthy, anesthetized dogs.
Morgan
M R
MR
Department of Clinical Sciences, Veterinary Teaching Hospital, Colorado State University, Fort Collins 80523-1620, USA.
Gaynor
J S
JS
Monnet
E
E
D000667:Ampicillin / Q000494:pharmacology*; D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002437:Cefazolin / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology*; D004285:Dogs / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous / Q000662:veterinary
D000900:Anti-Bacterial Agents; D002440:Cefoxitin; D000667:Ampicillin; D002437:Cefazolin