[The use of bromocryptin--Richter for the suppression of the onset of lactation after the interruption of pregnancy between the 14th and 28th gestational weeks--a preliminary report].
The effect and side reactions of bromocriptin of the firm "Richter" were evaluated in this study. Fifteen women with interrupted pregnancy between 14 and 28 gestational week were explored. To prevent the onset of lactation treatment was started within a few hours after abortion in dosage 2.5 mg (one tablet) twice daily, for 14 days. The prolactin-lowering action began to take effect 2 hours after ingestion of the first tablet, peak after 5 hours, and maintained for 8-12 hours. In course of treatment 14 days in dosage two times daily, the lactation was inhibited in 100% of the cases, in 65% of them she was stopped at the first three days of therapy, in 15% of the cases she was stopped between 3rd and 7th day, and in 20%--after the 7th day of the treatment. The adverse reactions nausea, dizziness, vomiting, diarrhoea, constipation, headache and orthostatic hypotension were transitory. They were observed rarely, and during the first 3-5 days of treatment disappeared.
Marinov
B
B
Tsankova
M
M
Damianov
L
L
D000032:Abortion, Therapeutic; D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects / Q000627:therapeutic use*; D003864:Depression, Chemical; D005260:Female; D006727:Hormone Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007774:Lactation / Q000187:drug effects*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D013997:Time Factors
D006727:Hormone Antagonists; D001971:Bromocriptine