title: [Clinicopathological characteristics of Burkitt lymphoma].
abstract: In the new WHO classification, the category of Burkitt lymphoma includes classic Burkitt lymphoma and a variant-Burkitt-like-lymphoma. In addition, three subcategories--endemic, non-endemic, and immunodeficiency-associated--were proposed to reflect the major clinical and genetic subtypes of this disease. Endemic Burkitt lymphoma is well known to carry EB virus(EBV). However, not more than 20% of the sporadic Burkitt lymphoma carry EBV. One of the three alternative forms of the Ig/myc translocation are regularly present in all Burkitt lymphomas, whether EBV positive or negative. Thus, translocation, rather than EBV, must be considered as the main rate-limiting event in the development of Burkitt lymphoma. EBV may increase the probability of this event by expanding the target cell population at risk.
authors.affiliation: Department of Medicine III, Hamamatsu University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Ohnishi
mesh_terms: D002051:Burkitt Lymphoma / Q000209:etiology / Q000235:genetics / Q000821:virology; D002898:Chromosomes, Human, Pair 8; D016259:Genes, myc; D004854:Herpesvirus 4, Human; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000235:genetics; D014178:Translocation, Genetic
chemical_list: D007147:Immunoglobulin Light Chains