Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities.
A reticular pattern on high resolution CT (HRCT) invariably represents significant lung pathology and is the dominant feature of irreversible fibrosis. We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis. Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.
Sheehan
R E
RE
Department of Radiology, Royal Brompton Hospital, London, England.
Wells
A U
AU
Milne
D G
DG
Hansell
D M
DM
D000368:Aged; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D008297:Male; D009582:Nitrofurantoin / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000000981:diagnostic imaging; D012075:Remission, Spontaneous; D014057:Tomography, X-Ray Computed; D014552:Urinary Tract Infections / Q000188:drug therapy
D009582:Nitrofurantoin