Vascular cell adhesion molecule-1 in normal, failed, and ectopic pregnancy.
OBJECTIVE
Vascular cell adhesion molecule-1 (VCAM-1) is involved in early pregnancy establishment. This study sought to determine whether soluble VCAM-1 (sVCAM-1) serum levels differ among normal, failed, and ectopic pregnancy, its capacity to serve as a marker for pregnancy viability or ectopic pregnancy, and its correlation with serum progesterone and beta human chorionic gonadotrophin (PHCG) levels.


METHODS
Maternal serum samples were obtained from 20 women with ectopic, 10 with normal, and 10 with failed intra-uterine pregnancy, all of comparable gestational age. Samples were assayed for sVCAM-1, progesterone, and betaHCG by specific assays.


RESULTS
The median serum level of sVCAM-1 was comparable between the three pregnancy types (normal: 578.3 ng/mL, range 434.4-699.5 ng/mL; failed: 567.8 ng/mL, range 401.9 669.5 ng/mL; and ectopic: 470.7ng/mL range, 328.2-1151.1 ng/mL). Serum levels sVCAM-1 were not significantly correlated with betaHCG or progesterone levels.


CONCLUSIONS
sVCAM-1 is not appropriate to serve as a marker for pregnancy viability or ectopic pregnancy.
Daniel
Y
Y
Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. danzv@green.co.il
Geva
E
E
Eshed-Englender
T
T
Gamzu
R
R
Lessing
J B
JB
Bar-Am
A
A
Amit
A
A
D000022:Abortion, Spontaneous / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005865:Gestational Age; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000097:blood*; D011374:Progesterone / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D006063:Chorionic Gonadotropin; C062304:HCG-beta, des-(122-145)-; D019010:Vascular Cell Adhesion Molecule-1; D011374:Progesterone