title: Effects of changes in packed cell volume on the specific heat capacity of blood: implications for studies measuring heat exchange in extracorporeal circuits.
abstract: Extracorporeal circuits such as cardiopulmonary bypass (CPB) and renal dialysis machines cause active and/or passive loss of body heat. Attempts to quantify this heat loss are generally based on the Fick principle which requires knowledge of the specific heat capacity (SHC) of blood. As changes in packed cell volume are common, we investigated the effect of these changes on the SHC of blood over a range of packed cell volumes (PCV) from whole blood at 43.1% (3594 J kg-1 degrees C-1) to pure Hartmann's solution (4153 J kg-1 degrees C-1). The SHC of other fluids used during CPB was also measured and found to be 4139 J kg-1 degrees C-1 and 4082 J kg-1 degrees C-1 for normal saline and Gelofusine, respectively. The maximum variability in SHC over the range of PCV values encountered during CPB was calculated to be small (5.5%). We conclude that use of a constant value of SHC for calculation of thermal energy transfer is currently justified.
authors.affiliation: Department of Medical Physics and Bioengineering, Southampton General Hospital, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Blake
authors.forename: G W
authors.initials: GW
authors.lastname: Petley
authors.forename: C D
authors.initials: CD
authors.lastname: Deakin
mesh_terms: D001790:Blood Physiological Phenomena; D001833:Body Temperature Regulation / Q000502:physiology*; D002315:Cardiopulmonary Bypass; D006400:Hematocrit; D006358:Hot Temperature; D006801:Humans; D007036:Hypothermia, Induced; D008954:Models, Biological; D017694:Rewarming