title: Linking Hebb's coincidence-detection to memory formation.
abstract: The theoretical foundations of learning and memory were laid by Donald Hebb 50 years ago. Recent genetic experiments that enhanced coincidence-detection of the NMDA receptor (a molecular master-switch in implementing Hebb's rule) and that led to better learning and memory in adult animals have substantially validated Hebb's rule in memory formation in the brain.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA. jtsien@princeton.edu
authors.forename: J Z
authors.initials: JZ
authors.lastname: Tsien
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation / Q000235:genetics* / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants; D008959:Models, Neurological; D009473:Neuronal Plasticity / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D013998:Time Perception / Q000502:physiology*
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate