title: [Expression of P62c-myc protein in breast cancer and its clinical significance].
abstract: The objective of this study was to determine the clinical significance of P62c-myc protein expression in breast cancer. P62c-myc protein was detected in 107 patients with breast cancer by immunohistochemical techniques (LSAB). The results showed that the positive rate of P62c-myc protein expression was 63.55% (68/107). The overexpression of P62c-myc protein related negatively with survival. 94.00% of the cases with overexpression of P62c-myc protein survived < or = 5 years, 65.00% survived > 5 years-< 10 years, and 21.62% survived > or = 10 years. There were significant associations of P62c-myc expression with advance clinical stage, high histological grade, and positive axillary node status in breast cancers. All of these findings suggested that overexpression of P62c-myc might be an important prognostic factor, and the detection of P62c-myc protein might be arranged as a regular pathological examination in the cases of breast cancer.
authors.affiliation: Department of General Surgery, First Affiliated Hospital, Chengdu.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Zhou
authors.forename: R
authors.initials: R
authors.lastname: Hu
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Yao
authors.forename: Q
authors.initials: Q
authors.lastname: Long
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Xing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D015996:Survival Rate
chemical_list: D016271:Proto-Oncogene Proteins c-myc