title: [Mitogenic effects of staphylococcal antigenic substances on irradiated lymphocytes from Wistar rats].
abstract: Proliferation activity of lymphocytes from rats was studied using a micromethod of blasttransformation reaction after X-ray irradiation (absorbed doses for animals were 0.5 and 1 Gy). Staphylococcus protein A and peptidoglycan stimulated the proliferation of irradiated lymphocytes. It was assumed that staphylococcus antigen substances held radiation protective effects. Staphylococcus protein A may be used for stabilization of lymphopoesis and functional activity of humoral and cellular immunity in irradiated animals due to T- and B-mitogenic properties.
authors.affiliation: T.G. Shevchenko State University, Kyiv, Ukraine.
authors.forename: L S
authors.initials: LS
authors.lastname: Kholodna
authors.forename: O H
authors.initials: OH
authors.lastname: Holeva
authors.forename: T A
authors.initials: TA
authors.lastname: Liubchenko
authors.forename: M Ie
authors.initials: MIe
authors.lastname: Kucherenko
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D010457:Peptidoglycan / Q000494:pharmacology*; D011830:Radiation Effects; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013205:Staphylococcal Protein A / Q000494:pharmacology*
chemical_list: D008934:Mitogens; D010457:Peptidoglycan; D011837:Radiation-Protective Agents; D013205:Staphylococcal Protein A