Omega-3 fatty acids alter soluble markers of endothelial function in coronary heart disease patients.
Several studies have indicated that omega-3 poly-unsaturated fatty acids in fish oil have protective effects on cardiovascular disease by reducing vascular endothelial inflammation in atherosclerosis. In a recent study, supplementation of patients with fish oil following coronary angioplasty elevated levels of lipid peroxides and two adhesion molecules in plasma suggesting a proinflammatory action of fish oil. However, decreases in several plasma markers of endothelial hemostatic activity indicated a healthier and better vasculature associated with fish oil supplementation.
Meydani
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Vascular Biology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.
D001161:Arteriosclerosis / Q000097:blood / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control*; D004730:Endothelium, Vascular / Q000502:physiology*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D006801:Humans
D015415:Biomarkers; D015525:Fatty Acids, Omega-3