title: Systematic reviews on leptospirosis.
abstract: OBJECTIVE
  To find the existing clinical evidence on interventions for leptospirosis. The objective is to evaluate the effectiveness and safety of any intervention on leptospirosis through systematic reviews of randomized controlled trials (RCTs).
  
  
  METHODS
  The sources of studies used (where there were no limitations concerning language, date, or other restrictions) were: EMBASE, LILACS, MEDLINE, the Cochrane Controlled Clinical Trials Database, and the Cochrane Hepato-Biliary Group Randomized Trials register.
  
  
  METHODS
  
  
  
  METHODS
  All systematic reviews of randomized controlled trials.
  
  
  METHODS
  patients with clinical and/or laboratorial diagnosis of leptospirosis, and subjects potencially exposed to leptospirosis as defined by the authors
  
  
  METHODS
  any intervention for leptospirosis (as antibiotics or vaccines for prevention or treatment).
  
  
  METHODS
  The assessment will be independently made by the reviewers and cross-checked. The external validity was assessed by analysis of: studies, interventions, and outcomes.
  
  
  RESULTS
  Located 163 studies using the search strategy described above, at the electronic databases above. Only 2 hits were selected, which are protocols of systematic reviews of Cochrane Collaboration, and not full reviews. One of the protocols evaluates antibiotics for treatment, and the other evaluates antibiotics for prevention of leptospirosis.
  
  
  CONCLUSIONS
  There were not complete systematic reviews on interventions for leptospirosis. Any interventions for leptospirosis, such as prevention and treatment remains unclear for guidelines and practice.
authors.affiliation: Federal University of São Paulo, SP, Brazil.
authors.forename: F
authors.initials: F
authors.lastname: Guidugli
authors.forename: A A
authors.initials: AA
authors.lastname: Castro
authors.forename: A N
authors.initials: AN
authors.lastname: Atallah
mesh_terms: D016206:Databases, Bibliographic; D019317:Evidence-Based Medicine; D006801:Humans; D007922:Leptospirosis / Q000628:therapy*; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic