title: Methyl bromide 1-year dietary study in dogs.
abstract: Average human exposure resulting from consumption of methyl I bromide (MB)-fumigated food has been estimated to be 0.00125 mg/kg/day. A 1-yr feeding study in beagle dogs was conducted as a safety study in which the high-dose diet was intended to yield a methyl bromide dose of at least 100 times the calculated human dietary exposure. Diets were fumigated with MB and fed to the dogs daily, except for weekends and holidays. MB consumption each feeding day was calculated as a time weighted average (TWA) that accounted for the rate of degassing from the fumigated diet and the rate of feed consumption during the feeding period. TWA compound consumption in the loss-, mid- and high-dose groups, respectively, averaged 0.06 ¿ 0.02, 0.13 ¿ 0.03 and 0.28 ¿ 0.08 mg/kg/day in males and 0.07 ¿ 0.03, 0.12 ¿ 0.03 and 0.27 ¿ 0.09 mg/kg/day in females. Clinical observations, body weight and feed consumption, ophthalmology, clinical pathology, urinalysis, organ weights and macroscopic and microscopic pathology were comparable in control and MB-treated dogs. Under the conditions of this study. the no-observed-effect level (NOEL) for MB was at least 0.28 mg/ kg/day, or approximately 200 times the expected average human dietary exposure.
authors.affiliation: Experimental Pathology Laboratories, Inc., Bowman Gray Technical Center, Winston-Salem, NC 27102, USA.
authors.forename: N H
authors.initials: NH
authors.lastname: Wilson
authors.forename: P E
authors.initials: PE
authors.lastname: Newton
authors.forename: M
authors.initials: M
authors.lastname: Rahn
authors.forename: H F
authors.initials: HF
authors.lastname: Bolte
authors.forename: R L
authors.initials: RL
authors.lastname: Suber
mesh_terms: D000284:Administration, Oral; D000818:Animals; D004032:Diet; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D011634:Public Health; D012449:Safety
chemical_list: D006842:Hydrocarbons, Brominated; D007306:Insecticides; C005218:methyl bromide