title: Recombinant bovine somatotropin: association with reproductive performance in dairy cows.
abstract: A clinical trial was performed to determine the effect of bST on reproductive performance in dairy cows on 4 Michigan dairy farms when bST was used according to labeled directions. Holstein cows (n = 555) at 4 Michigan dairy farms were randomly assigned to receive bovine somatotropin (bST) or to serve as untreated controls. Bovine somatotropin (500 mg, s.c.) was administered every 14 d beginning at 63 to 69 d of lactation and continuing until approximately 21 d prior to the end of lactation or until the producer removed the animal from the herd. A total of 229 (42.57%) animals consisting of 112 (48.91%) controls and 117 (51.09%) bST-treated cows were not diagnosed pregnant and were considered as having reproductive failure by 150 d of lactation and 92 (17.10%) of the animals consisting of 45 (48.91%) controls and 47 (51.09%) bST-treated cows had reproductive failure at the end of their lactation. No significant difference in the incidence of reproductive failure existed between the study treatment groups during either time frame. Cows with cystic ovarian disease had more instances of reproductive failure at 150 d of lactation than cows without this disease. Cows with dystocia, twin births, metritis, displaced abomasum and cystic ovarian disease had more instances of reproductive failure by the end of lactation than cows without these diseases. The bST-treated cows developed more nonspecific off feed conditions during the study lactation and had more twin births at the calving following bST administration compared to control cows. No differences were found between the study treatment groups in calculations of reproductive parameters. Logistic regression analysis found no significant effect of bST on reproductive failure; the odds ratios for the bST treatment effect on reproductive failure at 150 d of lactation and reproductive failure at the end of lactation were 0.95 (95% CI 0.67 to 1.36) and 0.95 (95% CI 0.59 to 1.54), respectively. Overall, bST was not found to have a significant impact on reproductive performance in the herds studied.
authors.affiliation: Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48823, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Judge
authors.forename: P C
authors.initials: PC
authors.lastname: Bartlett
authors.forename: J W
authors.initials: JW
authors.lastname: Lloyd
authors.forename: R J
authors.initials: RJ
authors.lastname: Erskine
mesh_terms: D000034:Abortion, Veterinary / Q000453:epidemiology; D000818:Animals; D001947:Breeding / Q000379:methods; D002417:Cattle; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology*; D007774:Lactation; D008824:Michigan; D011247:Pregnancy; D011248:Pregnancy Complications / Q000145:classification / Q000662:veterinary; D011270:Pregnancy, Animal; D012098:Reproduction / Q000187:drug effects*
chemical_list: D013006:Growth Hormone