A 20-year-old man with eosinophilia and easy bruisability.
Acquired platelet dysfunction with eosinophilia is a rare, benign self-limiting disorder characterised by platelet dysfunction and an association with parasitic infections. A 20-year-old national serviceman who presented with easy bruising and spontaneous epistaxis is reported. Investigations revealed eosinophilia and an abnormal platelet function test similar to that seen in patients with Glanzmann's thrombasthenia infections. He also had evidence of hookworm infestation. Following a course of mebendazole, his symptoms and platelet dysfunction resolved. Hence, this disorder of acquired platelet dysfunction with eosinophilia should be considered in patients with bleeding disorders secondary to platelet dysfunction.
Lim
L C
LC
Department of Haematology, Singapore General Hospital, Singapore.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000469:parasitology / Q000473:pathology; D003288:Contusions / Q000503:physiopathology; D004802:Eosinophilia / Q000209:etiology* / Q000469:parasitology / Q000473:pathology; D004844:Epistaxis / Q000209:etiology; D006725:Hookworm Infections / Q000150:complications*; D006801:Humans; D008297:Male