Obtaining marginal estimates from conditional categorical repeated measurements models with missing data.
The most commonly used models for categorical repeated measurement data are log-linear models. Not only are they easy to fit with standard software but they include such useful models as Markov chains and graphical models. However, these are conditional models and one often also requires the marginal probabilities of responses, for example, at each time point in a longitudinal study. Here a simple method of matrix manipulation is used to derive the maximum likelihood estimates of the marginal probabilities from any such conditional categorical repeated measures model. The technique is applied to the classical Muscatine data set, taking into account the dependence of missingness on previous observed values, as well as serial dependence and a random effect.
Lindsey
J K
JK
Department of Biostatistics, Limburgs Universitair Centrum, B-3590 Diepenbeek, Belgium. jlindsey@luc.ac.be
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008137:Longitudinal Studies; D008297:Male; D008390:Markov Chains; D015233:Models, Statistical; D011336:Probability; D012107:Research Design; D012307:Risk Factors