Direct coronary vasomotor effects of sevoflurane and desflurane in in situ canine hearts.
BACKGROUND
An extracorporeal system was used to investigate the direct coronary vasomotor effects of sevoflurane and desflurane in vivo. The role of the adenosine triphosphate-sensitive potassium channels (KATP channels) in these effects was evaluated.


METHODS
Twenty-one open-chest, anesthetized (fentanyl-midazolam) dogs were studied. The left anterior descending coronary artery was perfused at controlled pressure (80 mmHg) with normal arterial blood or arterial blood equilibrated with either sevoflurane or desflurane. Series 1 (n = 16) was divided into two groups of equal size on the basis of whether sevoflurane (1.2, 2.4, and 4.8%) or desflurane (3.6, 7.2, and 14.4%) was studied. The concentrations for the anesthetics corresponded to 0.5, 1.0, and 2.0 minimum alveolar concentration (MAC), respectively. Coronary blood flow (CBF) was measured with an ultrasonic, transit-time transducer. Local coronary venous samples were obtained and used to evaluate changes in myocardial oxygen extraction (EO2). In series 2 (n = 5), changes in CBF by 1 MAC sevoflurane and desflurane were assessed before and during intracoronary infusion of the KATP channel inhibitor glibenclamide (100 microg/min).


RESULTS
Intracoronary sevoflurane and desflurane caused concentration-dependent increases in CBF (and decreases in EO2) that were comparable. Glibenclamide blunted significantly the anesthetic-induced increases in CBF.


CONCLUSIONS
Sevoflurane and desflurane have comparable coronary vasodilative effects in in situ canine hearts. The KATP channels play a prominent role in these effects. When compared with data obtained previously in the same model, the coronary vasodilative effects of sevoflurane and desflurane are similar to those of enflurane and halothane but considerably smaller than that of isoflurane.
Crystal
G J
GJ
Department of Anesthesiology, Illinois Masonic Medical Center, Univeristy of Illinois College of Medicine, Chicago 60657, USA. gcrystal@uic.edu
Zhou
X
X
Gurevicius
J
J
Czinn
E A
EA
Salem
M R
MR
Alam
S
S
Piotrowski
A
A
Hu
G
G
D018528:ATP-Binding Cassette Transporters; D018685:Anesthetics, Inhalation / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects*; D003331:Coronary Vessels / Q000187:drug effects*; D000077335:Desflurane; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D005905:Glyburide / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007530:Isoflurane / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D054086:KATP Channels; D008297:Male; D008738:Methyl Ethers / Q000097:blood / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D000077149:Sevoflurane; D014664:Vasodilation / Q000187:drug effects
D018528:ATP-Binding Cassette Transporters; D018685:Anesthetics, Inhalation; D054086:KATP Channels; D008738:Methyl Ethers; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; C092520:uK-ATP-1 potassium channel; D000077149:Sevoflurane; D000077335:Desflurane; D007530:Isoflurane; D005905:Glyburide