Hippocampus formation: an intriguing collaboration.
Recent genetic studies have shown that the signalling factor Wnt3a is required for formation of the hippocampus; the developmental consequences of Wnt signalling in the hippocampus are mediated by multiple HMG-box transcription factors, with LEF-1 being required just for formation of the dentate gyrus.
Roelink
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Department of Biological Structure, Center for Developmental Biology, University of Washington, Box 357420, Seattle, 98117-7420, USA. roelink@u.washington.edu
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D004627:Embryonic Induction; D006609:High Mobility Group Proteins / Q000235:genetics*; D006624:Hippocampus / Q000196:embryology*; D051821:Lymphoid Enhancer-Binding Factor 1; D051379:Mice; D008817:Mice, Mutant Strains; D011506:Proteins / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*; D051153:Wnt Proteins; D060508:Wnt3 Protein; D060509:Wnt3A Protein
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; C497574:Lef1 protein, mouse; D051821:Lymphoid Enhancer-Binding Factor 1; D011506:Proteins; D014157:Transcription Factors; D051153:Wnt Proteins; D060508:Wnt3 Protein; D060509:Wnt3A Protein; C555511:Wnt3a protein, mouse