[Long-term results of small cell lung cancer treated by surgery combined with postoperative chemotherapy: a report of 65 patients].
OBJECTIVE
To analyse the long term results of small cell lung cancer (SCLC) treated by surgery combined with postoperative chemotherapy.


METHODS
From 1983 to 1994, 65 patients with SCLC were treated by surgery combined with postoperative chemotherapy, and 22 of them received prophylactic cranial irradiation.


RESULTS
In 64 evaluable patients, the overall 1-, 3- and 5-year survival rates were 87.5%, 53.2% and 36.3%. Patients treated by radical operation plus chemotherapy gave 1-, 3- and 5-year survival rates of 92.5%, 58.5% and 43.8%. The prognostic surviving factors as analysed showed that statistical differences were observed between stage I and II, I and III A (P < 0.03), N0 and N1 (P < 0.021) in 3-year survival rate, between 2-3 and 4-6 cycle chemotherapy in 1-year survival rate (P < 0.007).


CONCLUSIONS
Surgery combined with postoperative chemotherapy and radiotherapy is preferred for stages I and II, N0 and N1 lesions of SCLC.
Zhang
X
X
Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Sun
Y
Y
Huang
J
J
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018288:Carcinoma, Small Cell / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011184:Postoperative Period; D015996:Survival Rate; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D008727:Methotrexate