Links between replication, recombination and genome instability in eukaryotes.
Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements.
Flores-Rozas
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Ludwig Institute for Cancer Research, Cancer Center and Dept of Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA.
Kolodner
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RD
D004249:DNA Damage; D004261:DNA Replication; D005057:Eukaryotic Cells; D016678:Genome; D011995:Recombination, Genetic