[Mitogenic effects of staphylococcal antigenic substances on irradiated lymphocytes from Wistar rats].
Proliferation activity of lymphocytes from rats was studied using a micromethod of blasttransformation reaction after X-ray irradiation (absorbed doses for animals were 0.5 and 1 Gy). Staphylococcus protein A and peptidoglycan stimulated the proliferation of irradiated lymphocytes. It was assumed that staphylococcus antigen substances held radiation protective effects. Staphylococcus protein A may be used for stabilization of lymphopoesis and functional activity of humoral and cellular immunity in irradiated animals due to T- and B-mitogenic properties.
Kholodna
L S
LS
T.G. Shevchenko State University, Kyiv, Ukraine.
Holeva
O H
OH
Liubchenko
T A
TA
Kucherenko
M Ie
MIe
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects*; D008297:Male; D008934:Mitogens / Q000494:pharmacology*; D010457:Peptidoglycan / Q000494:pharmacology*; D011830:Radiation Effects; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013205:Staphylococcal Protein A / Q000494:pharmacology*
D008934:Mitogens; D010457:Peptidoglycan; D011837:Radiation-Protective Agents; D013205:Staphylococcal Protein A