title: Sin nombre virus (SNV) Ig isotype antibody response during acute and convalescent phases of hantavirus pulmonary syndrome.
abstract: Serum samples from 22 hantavirus pulmonary syndrome (HPS) patients were tested for Sin Nombre virus (SNV)-reactive antibodies. In the acute phase of HPS, 100% and 67% of the samples tested positive for SNV-specific immunoglobulin (Ig) M and IgA, respectively. Among the virus-specific IgG antibodies, the most prevalent were IgG3 (in 97% of samples), followed by IgG1 (70%), IgG2 (30%), and IgG4 (3%).
authors.affiliation: Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: P
authors.initials: P
authors.lastname: Bostik
authors.forename: J
authors.initials: J
authors.lastname: Winter
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: P E
authors.initials: PE
authors.lastname: Rollin
authors.forename: F
authors.initials: F
authors.lastname: Villinger
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: C J
authors.initials: CJ
authors.lastname: Peters
authors.forename: A A
authors.initials: AA
authors.lastname: Ansari
mesh_terms: D000208:Acute Disease; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral; D002908:Chronic Disease; D006476:Orthohantavirus / Q000276:immunology*; D018804:Hantavirus Pulmonary Syndrome / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification; D007132:Immunoglobulin Isotypes / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood; D011379:Prognosis
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M