Head and neck schwannomas--a 10 year review.
Schwannomas of the head and neck are uncommon tumours that arise from any peripheral, cranial or autonomic nerve. Twenty-five to 45 per cent of extracranial schwannomas occur in the head and neck region and thus are usually in the domain of the otolaryngologist. They usually present insidiously and thus are often diagnosed incorrectly or after lengthy delays, however, better imaging and cytological techniques have lessened this to some degree more recently. For benign lesions conservative surgical excision is the treatment of choice bearing in mind possible vagal or sympathetic chain injury. Malignant schwannomas are best treated with wide excision where possible. The role of adjuvant therapy remains uncertain and irrespective of treatment modality prognosis is poor with an overall survival of 15 per cent. However, recent advances in ras oncogene inhibitors may hold hope for the future.
Colreavy
M P
MP
Department of Otolaryngology-Head and Neck Surgery Beaumont Hospital, Dublin, Ireland.
Lacy
P D
PD
Hughes
J
J
Bouchier-Hayes
D
D
Brennan
P
P
O'Dwyer
A J
AJ
Donnelly
M J
MJ
Gaffney
R
R
Maguire
A
A
O'Dwyer
T P
TP
Timon
C V
CV
Walsh
M A
MA
D000328:Adult; D000368:Aged; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014057:Tomography, X-Ray Computed; D018608:Ultrasonography, Doppler