[The role of serum 'adhesive factor' and leukocyte sensitization in pathogenesis of multiple sclerosis].
The reactivity to the myelin basic protein, brain gangliosides purified derivative and also the influence of the serum on the cells adherence were determined by micromodification of the leukocyte adherence inhibition (LAI) test. 46 multiple sclerosis patients, 21 patients with hereditary disease and 41 donors were examined. The cellular sensitization to the myelin basic protein and brain gangliosides was revealed in 57% of the multiple sclerosis patients. The leukocyte adherence was increase in 53.5% patients when autologous serum was added. The adherence factor was most often found (90% case) in patients with severe neurological deficit. It is suggested that this factor is a connected t the increased levels of circulating adhesion molecules in multiple sclerosis patients.
Zhirnova
I G
IG
Research Institute of Neurology of the Russian Acad Med Sci., 123367, Russia.
Tsareva
M I
MI
Erofeeva
A V
AV
Zavalishin
I A
IA
Gannushkina
I V
IV
D001426:Bacterial Proteins / Q000276:immunology / Q000502:physiology; D001921:Brain / Q000378:metabolism; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000097:blood / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D006801:Humans; D007106:Immune Sera; D007962:Leukocytes / Q000276:immunology* / Q000502:physiology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009186:Myelin Sheath / Q000276:immunology / Q000502:physiology
D001426:Bacterial Proteins; D015815:Cell Adhesion Molecules; D005732:Gangliosides; D007106:Immune Sera; C030960:tuberculoprotein, Mycobacterium tuberculosis