title: Origins of signalling and memory: matters of life versus death.
abstract: This review focuses on the principles in cell-cell communication and cellular ability to respond to external chemical changes which have been so crucial for the development of life on planet Earth. We now know that the capacity of free-living organisms which evolved more than a billion years ago to respond to intercellular signal molecules, originating either from themselves or from other sources in their vicinity, is so similar possibly even more sophisticated - to that of the cells in our own body, and these findings have had a major impact on our struggle to understand how life has evolved and how it can be maintained. Attention is drawn to the very important topic of mechanisms in cell death, being seen as an aggressive and very powerful instrument in the continuance of life and ability of life to proliferate into a plethora of new species, and use insulin-related material as our paradigm. Such signal molecules (hormones) may have played a major role in cellular maintenance throughout evolution.
authors.affiliation: Department of Pathology, University Medical School, Aberdeen, Scotland, UK.
authors.forename: D N
authors.initials: DN
authors.lastname: Wheatley
authors.forename: S T
authors.initials: ST
authors.lastname: Christensen
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D007328:Insulin / Q000494:pharmacology; D007447:Invertebrate Hormones / Q000494:pharmacology; D008568:Memory / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D007328:Insulin; D007447:Invertebrate Hormones