Distribution of cadmium in selected organs of mice: effects of cadmium on organ contents of retinoids and beta-carotene.
Cadmium was administered to 32 adult ICR mice i.p. in two single doses (0.25 and 0.5 mg CdCl2, per kg of b.w.). After 48 hours concentrations of cadmium in kidneys, liver, spleen, muscle (m. quadriceps femoris), ovaries and testes and the concentration of retinyl palmitate, retinol and beta-carotene in kidney, liver and testes were determined. Significantly higher cadmium concentration was found in liver, kidney and ovary in both experimental groups in comparison with the control group (p<0.001). In muscle, spleen and testis the cadmium level was higher, however not significantly. No significant differences in the concentration of retinyl palmitate, retinol and alpha-carotene in liver were found. Concentration of alpha-carotene in kidney and testis was significantly decreased in both groups administered with cadmium (p<0.001). Concentration of retinyl palmitate was significantly lower in testis in the group with higher cadmium level (p<0.001) and the concentration of retinol significantly decreased in kidney and testis of mice after an administration of 0.5 mg CdCl2/kg b.w.
Massányi
P
P
Department of Physiology and Anatomy of Farm Animals, Faculty of Agronomy, University of Agriculture, Nitra, Slovak Republic. massanyi@afnet.uniag.sk
Bárdos
L
L
Oppel
K
K
Hluchý
S
S
Kovácik
J
J
Csicsai
G
G
Toman
R
R
D000818:Animals; D016588:Anticarcinogenic Agents / Q000493:pharmacokinetics; D000975:Antioxidants / Q000378:metabolism*; D002104:Cadmium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D051379:Mice; D008813:Mice, Inbred ICR; D012176:Retinoids / Q000378:metabolism*; D000084562:Retinyl Esters; D014018:Tissue Distribution / Q000187:drug effects; D014801:Vitamin A / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D019207:beta Carotene / Q000378:metabolism*
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D004224:Diterpenes; D012176:Retinoids; D000084562:Retinyl Esters; D002104:Cadmium; D019207:beta Carotene; D014801:Vitamin A; C014794:retinol palmitate