title: CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types.
abstract: The tumor suppressor p53 exerts its antioncogenic effects in cells chiefly by regulating their progression through the cell cycle and by inducing cell death. It has been claimed that p53-transduced apoptosis involves the death receptor CD95 (Fas/APO-1). We report that thymocytes from mice lacking functional Fas ligand (gld) show normal sensitivity to apoptosis transduced by p53, and that hepatocytes fromp53-/- mice have normal sensitivity to apoptosis triggered through ligation of CD95. p53 and CD95, therefore, function in independent pathways to cell death in these diverse cell types.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
authors.forename: L
authors.initials: L
authors.lastname: O'Connor
authors.forename: A W
authors.initials: AW
authors.lastname: Harris
authors.forename: A
authors.initials: A
authors.lastname: Strasser
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D005786:Gene Expression Regulation; D016158:Genes, p53; D051379:Mice; D008815:Mice, Inbred Strains; D015398:Signal Transduction / Q000235:genetics*; D013045:Species Specificity; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism; D019014:fas Receptor / Q000235:genetics* / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D019014:fas Receptor