title: Pulmonary embolism and intracardiac thrombi--individual therapeutic procedures.
abstract: Mobile right heart thrombus is a severe but rare presentation of thromboembolic disease and usually coexists with an already massive pulmonary embolism (PE). But looking at the literature there is no clear consensus on therapeutic management. We therefore tried to find possible therapeutic guidelines and to evaluate an optimal diagnostic procedure looking at three patients who presented at our department with mobile right heart thrombus in the last year. The first patient with a small (diameter = 1 cm) thrombus in the right ventricle and peripheral pulmonary embolism underwent successful thrombolytic therapy without any complications. Patients II and III showed large intracardiac masses, in patient III extending into the superior vena cava, with central PE. These two patients underwent pulmonary arteriotomy. The diagnostic line in each case was transthoracal echocardiography followed by a helix lung CT scan. Only patients with small intracardiac thrombi and thrombotic masses in the peripheral pulmonary arteries but with hemodynamically significant PE should be treated with thrombolytic agents.
authors.affiliation: Department of Internal Medicine, Karl-Franzens University Graz, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Brodmann
authors.forename: G
authors.initials: G
authors.lastname: Stark
authors.forename: E
authors.initials: E
authors.lastname: Pabst
authors.forename: A
authors.initials: A
authors.lastname: Lueger
authors.forename: E
authors.initials: E
authors.lastname: Pilger
mesh_terms: D003328:Coronary Thrombosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D004452:Echocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000601:surgery; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; C077412:unglycosylated rt-PA