title: Serum müllerian-inhibiting substance levels during normal menstrual cycles.
abstract: OBJECTIVE
  To measure serum levels of müllerian-inhibiting substance (MIS) during the normal menstrual cycle.
  
  
  METHODS
  Serum was collected from women during ovulation and the mid-luteal and early follicular phases of the menstrual cycles. It was stored frozen at -80 degrees C until assayed.
  
  
  METHODS
  University of Louisville Departments of Obstetrics and Gynecology and Surgery.
  
  
  METHODS
  Twenty healthy women 22-35 years of age with normal menstrual cycles.
  
  
  METHODS
  Blood samples were collected on menstrual cycle day two or three and on the day of LH surge plus one and plus seven or eight.
  
  
  METHODS
  Serum MIS levels were measured by using an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum MIS levels ranged from a low of 1.4 +/- 0.9 ng/mL (mean [+/-SD]) in the early follicular phase, peaked mid-cycle at 1.7 +/- 1.1 ng/mL, and decreased to 1.4 +/- 0.9 ng/mL in the mid-luteal phase of the normal menstrual cycle.
  
  
  CONCLUSIONS
  Fluctuations in serum MIS levels during the menstrual cycle suggest that MIS may have a regulatory role in folliculogenesis.
authors.affiliation: University of Louisville, Louisville, Kentucky, USA. clcook01@gwise.louisville.edu
authors.forename: C L
authors.initials: CL
authors.lastname: Cook
authors.forename: Y
authors.initials: Y
authors.lastname: Siow
authors.forename: S
authors.initials: S
authors.lastname: Taylor
authors.forename: M E
authors.initials: ME
authors.lastname: Fallat
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology*; D012016:Reference Values; D013735:Testicular Hormones / Q000097:blood*
chemical_list: D006023:Glycoproteins; D006131:Growth Inhibitors; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone