A case of sarcoidosis presenting as multiple pulmonary nodules, nasopharyngeal and cerebellopontine tumors.
A 64-year-old woman presented with multiple pulmonary nodules, and after spontaneous regression of the pulmonary lesions in six months, nasopharyngeal and right cerebellopontine tumors developed. Noncaseous epithelioid cell granulomas were demonstrated histologically in both resected pulmonary and nasopharyngeal tumors. She complained of hearing loss and tinnitus probably due to the cerebellopontine tumors. Corticosteroid therapy resulted in the improvement of these symptoms and the gradual decrease of tumor size. Although histological probe of the cerebellopontine tumors was not diagnostic, this patient was finally diagnosed as having sarcoidosis, based on the clinicopathological features, including systemic granulomatous lesions, MRI findings, and good response to corticosteroid therapy. The diagnosis of sarcoidosis is sometimes difficult when its clinical manifestations are uncommon.
Sugisaki
K
K
Third Department of Internal Medicine, Oita Medical University, Japan. sugisaki@oita-med.ac.jp
Miyazaki
E
E
Fukami
T
T
Sawabe
T
T
Kumamoto
T
T
Tsuda
T
T
Mori
T
T
D002526:Cerebellar Diseases / Q000209:etiology*; D002530:Cerebellopontine Angle; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D019786:Gadolinium DTPA