title: Functional derivatives of 5-benzo[1, 3]dioxol-5-yl-1-methyl-1H-imidazole-2-carbaldehyde and evaluation of leishmanicidal activity.
abstract: New imidazole derivatives were obtained after subjecting 5-benzo[1, 3]dioxol-5-yl-1-methyl-1H-imidazole-2-carbaldehyde to a Knoevenagel reaction. Some of these compounds exhibit significant in vitro leishmanicidal activity.
authors.affiliation: Laboratoire de chimie organique, faculté de pharmacie, 27, boulevard J. Moulin, 13385, Marseille, France. patrice.vanelle@pharmacie.univ.mrs.fr
authors.forename: P
authors.initials: P
authors.lastname: Vanelle
authors.forename: J
authors.initials: J
authors.lastname: Meuche
authors.forename: J
authors.initials: J
authors.lastname: Maldonado
authors.forename: M P
authors.initials: MP
authors.lastname: Crozet
authors.forename: F
authors.initials: F
authors.lastname: Delmas
authors.forename: P
authors.initials: P
authors.lastname: Timon-David
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D018314:Leishmania infantum / Q000187:drug effects*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: C409487:3-(5-benzo(1,3)dioxol-5-yl-1-methyl-1H-imidazol-2-yl)-2-nitroacrylamide; D000178:Acrylamides; D007093:Imidazoles