Effects of vacuum compression therapy on skin microcirculation in patients suffering from lower limb ischaemia.
BACKGROUND
We investigated the short-term effect of vacuum compression (VC) treatment on skin microcirculatory perfusion in the foot of patients with lower limb ischaemia and healthy controls.


METHODS
Ten patients with intermittent claudication or rest pain and 5 healthy controls underwent vacuum-compression treatment for half an hour. The leg was positioned in an air-tight plexiglass cylinder in which hypobaric (-115 mm Hg) and hyperbaric (75 mm Hg) pressure could be generated alternately, in order to improve peripheral circulation. The effect on skin microcirculation was investigated using nailfold capillary microscopy (measuring nutritive perfusion), laser Doppler fluxmetry (LDF) (total skin perfusion) and transcutaneous oxygen tension measurements (TcpO2).


RESULTS
A few patients experienced ischaemic symptoms during VC, probably because the leg was pinched off through inflation of the cuff. In both patients and controls capillary microscopic parameters did not change significantly. In some cases, microcirculatory perfusion decreased because the leg had cooled during the treatment. Application of a heating matrass annihilated this effect. Only in the patient group a few LDF- and TcpO2 parameters improved slightly, but significantly.


CONCLUSIONS
Vacuum-compression therapy only slightly improves total skin perfusion and oxygenation, but not the nutritive microcirculation, being an essential factor in the occurrence of ischaemic symptoms. We therefore conclude that this instrument in its present form is not an aid in the treatment of lower limb ischaemia.
Ubbink
D T
DT
Department of Vascular Surgery, Academic Medical Centre, Amsterdam, The Netherlands. D.Ubbink@amc.uva.nl
van der Oord
B M
BM
Sobotka
M R
MR
Jacobs
M J
MJ
D000368:Aged; D001274:Atmospheric Pressure; D001783:Blood Flow Velocity / Q000502:physiology; D001785:Blood Gas Monitoring, Transcutaneous; D004867:Equipment Design; D005260:Female; D005528:Foot / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000503:physiopathology / Q000628:therapy*; D017078:Laser-Doppler Flowmetry; D007866:Leg / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D020678:Microscopic Angioscopy; D008875:Middle Aged; D012867:Skin / Q000098:blood supply*; D014618:Vacuum