Soluble P-selectin and proinflammatory cytokines in patients with polygenic type IIa hypercholesterolemia.
Plasma soluble P-selectin (sP-selectin), beta-thromboglobulin (beta-TG), von Willebrand Factor (vWF), prothrombin factor 1+2 (F1+2), IL-6 and IL-1beta levels were analyzed in 35 consecutive patients with polygenic type IIa hypercholesterolemia (HC) and 35 age- and sex-matched healthy subjects. sP-selectin (p < 0.005), beta-TG (p < 0.05) and IL-1beta (p < 0.02) levels were higher in HC patients than healthy subjects whereas no significant difference was observed for vWF. sP-selectin directly correlated with beta-TG (p < 0.05) and IL-1beta levels (p < 0.005), but not with the other variables analyzed. A direct correlation was observed between F1+2 and IL-6 (p < 0.05), total cholesterol (p < 0.05) or LDL cholesterol (p < 0.05). We conclude that HC is associated with an increase of plasma sP-selectin levels, and that sP-selectin may be considered as a marker of in vivo platelet activation in type IIa polygenic HC. The correlations observed among the variables analyzed in the study suggest that proinflammatory cytokines might play a role in the prothrombotic state often associated with HC.
Ferroni
P
P
Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy. ferronipat@uni.net
Basili
S
S
Vieri
M
M
Martini
F
F
Labbadia
G
G
Bellomo
A
A
Gazzaniga
P P
PP
Cordova
C
C
Alessandri
C
C
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D018836:Inflammation Mediators / Q000097:blood*; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D010446:Peptide Fragments / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D012995:Solubility; D001620:beta-Thromboglobulin / Q000378:metabolism; D014841:von Willebrand Factor / Q000378:metabolism
D016207:Cytokines; D018836:Inflammation Mediators; D007375:Interleukin-1; D015850:Interleukin-6; D008074:Lipoproteins; D019007:P-Selectin; D010446:Peptide Fragments; D001620:beta-Thromboglobulin; C045879:prothrombin fragment 1.2; D014841:von Willebrand Factor; D011516:Prothrombin; D002784:Cholesterol