title: Usefulness of the severity and extent of wall motion abnormalities as prognostic markers of an adverse outcome after a first myocardial infarction treated with thrombolytic therapy.
abstract: The prognostic value of wall motion score index (WMSI), assessed at predischarge after a first acute myocardial infarction (AMI) in the thrombolytic era, is still not well known. One-hundred forty-four consecutive patients with a first AMI treated with thrombolytic therapy underwent exercise testing and echocardiography at rest before discharge and were followed-up for a mean period of 18 months. During follow-up, there were 32 cardiac events (12 patients had cardiac deaths, 8 had unstable angina pectoris, 1 had nonfatal reinfarction, and 11 patients had congestive heart failure). The patients who experienced any cardiac event had a higher WMSI (1.67+/-0.15 vs. 1.30+/-0.16, p<0.0001), a higher end-systolic volume (75.1+/-34 vs. 59.5+/-22 ml, p<0.01), and a lower ejection fraction (47+/-16% vs. 55+/-10%, p<0.001) at predischarge than patients without events. The incidence of a positive predischarge exercise testing did not differ between patients with and without cardiac events (22% vs. 24%, p = NS). Multivariate Cox regression analysis, including clinical, exercise results, and echocardiographic parameters, showed that the most powerful predictor of a subsequent event was a resting WMSI > or =1.50 before discharge (chi-square 17.8, p<0.0001). Thus, in patients with a first AMI who underwent thrombolysis, the severity and extent of echocardiographically detected wall motion abnormalities are important independent predictors of cardiac events.
authors.affiliation: Department of Clinical and Experimental Medicine, Policlinico Monteluce, University of Perugia, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Carluccio
authors.forename: S
authors.initials: S
authors.lastname: Tommasi
authors.forename: M
authors.initials: M
authors.lastname: Bentivoglio
authors.forename: M
authors.initials: M
authors.lastname: Buccolieri
authors.forename: L
authors.initials: L
authors.lastname: Prosciutti
authors.forename: L
authors.initials: L
authors.lastname: Corea
mesh_terms: D000368:Aged; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D010351:Patient Discharge; D011379:Prognosis; D016016:Proportional Hazards Models; D012720:Severity of Illness Index; D013318:Stroke Volume; D015912:Thrombolytic Therapy; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D005343:Fibrinolytic Agents