Trichosporon beigelii: a life-threatening pathogen in immunocompromised hosts.
Patients undergoing bone marrow transplantation are profoundly immunosuppressed as a result of their intensive myeloablative chemotherapy and are at high risk for opportunistic fungal infections mainly caused by Candida spp and Aspergillus spp. Trichosporon beigelii (T beigelii) has emerged as a life-threatening opportunistic pathogen in granulocytopenic and immunocompromised hosts and there is a marked increase in cases reported in the literature. Response to antifungal agents is poor, mortality is high and immunological recovery is the most important factor for a favorable outcome in patients with trichosporonosis. We present three cases of T. beigelii infection in patients undergoing allogeneic bone marrow transplantation in our center and we review cases described in the literature.
Erer
B
B
Divisione di Ematologia e Centro Trapianti Midollo Osseo di Muraglia, Pesaro, Italy.
Galimberti
M
M
Lucarelli
G
G
Giardini
C
C
Polchi
P
P
Baronciani
D
D
Gaziev
D
D
Angelucci
E
E
Izzi
G
G
D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology*; D002648:Child; D016638:Critical Illness; D005260:Female; D006086:Graft vs Host Disease; D006801:Humans; D016867:Immunocompromised Host; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000628:therapy; D007970:Leukopenia; D008297:Male; D009181:Mycoses / Q000209:etiology* / Q000276:immunology; D014184:Transplantation, Homologous; D014250:Trichosporon / Q000472:pathogenicity; D017086:beta-Thalassemia / Q000628:therapy