[Detection of antigen specificities of HLA-A, B loci in perennial allergic rhinitis].
In order to elucidate whether there are any features of HLA haplotype in perennial allergic rhinitis and the essentials of its genetic background, the antigen specificities of HLA-A, B loci in 31 non-kindred adult cases of southern Chinese of Han nationality were detected and calculated the antigen frequency, gene frequency and relative risk value of different alleles evaluated by serological methods. The results were compared with 78 healthy adult individuals of Guizhou Han (control group) and revealed that RR (relative risk) of HLA-B27 was as high as 8.25, RR of A31 (2.68), A28 (2.57), B12 (2.57) and A33 (2.27) were also higher than the control group. It is suggested that the presence of the above mentioned antigens are positively associated with the genetic liability of the patients. The RR of A9, B60, A24, B22, B51, B15, B16, B48, B46, B7, A11 and A2 were all lower than 1 representing the genetic stability to allergic rhinitis. The antigen frequency of B27 and A9 were significantly different from that of the control group.
Lin
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S
First Affiliated Hospital, Guiyang Medical College.
Liu
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R
Guo
H
H
D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000235:genetics / Q000276:immunology*
D015234:HLA-A Antigens; C037709:HLA-A9 antigen; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen