[The assessment of hepatic enzymes' levels in children treated for leukemia and non-Hodgkin's lymphomas].
The purpose of this study was to determine the frequent of serum aminotransferase elevation in children with leukemias and non-Hodgkin's lymphomas and define the cause of this pathology. In the serum of 43 children the bilirubin concentration, activities of aspartic aminotransferase (AspAT), alanine aminotransferase (AlAT) and gammaglutamylotranspeptidase (GGTP) were measured before treatment, during and after intensive chemotherapy. 43 patients 8 (65%) had bilirubin concentration above 1.2 mg/dl and/or aminotransferase activities above 100 U/l. The most possible causes of the liver damage in the patients were: hepatotoxicity of chemotherapy, virus or bacterial infections and leukemic or lymphomatous involvement of the liver.
Nowak
K
K
II Kliniki Chorób Dzieci Instytutu Pediatrii Akademii Medycznej w Lodzi.
Trelińska
J
J
Zalewska-Szewczyk
B
B
Stolarska
M
M
Bodalski
J
J
D000293:Adolescent; D000410:Alanine Transaminase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000009:adverse effects; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007938:Leukemia / Q000201:enzymology*; D008107:Liver Diseases / Q000175:diagnosis* / Q000201:enzymology; D008111:Liver Function Tests; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000201:enzymology*; D008297:Male; D012189:Retrospective Studies; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D000970:Antineoplastic Agents; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin