title: Serum free carnitine levels in children with kwashiorkor.
abstract: OBJECTIVE
  To determine the serum free carnitine concentration in normally nourished children and in children with kwashiorkor and to relate the carnitine concentration to the ability to oxidise exogenous long chain fatty acids in the body.
  
  
  METHODS
  A cross-sectional comparative study of two age-matched groups.
  
  
  METHODS
  Forty seven children with kwashiorkor and 47 age-matched normally nourished children.
  
  
  METHODS
  Fasting blood samples were enzymatically analysed for free carnitine levels. 13C labelled hiolein was administered orally and the recovery of 13C from the breath air was monitored after administration of the feed. The cumulative per cent dose (CUMPD) recovery of 13C 16 hours after the ingestion of labelled hiolein was determined.
  
  
  RESULTS
  Normal children had significantly higher free carnitine concentrations (mean = 60.7 mumol/l; 95% confidence interval of the mean = 42.7-77.8) than the kwashiorkor children (mean = 16.5 mumol/l; 95% confidence interval of the mean = 11.3-19.8)(p < 0.001). There was no correlation between serum free carnitine concentration and serum albumin in kwashiorkor subjects, but there was a significant correlation between serum free carnitine concentration and the degree of weight loss as indicated by the weight: weight for age and sex ratio. The greater the weight loss, the lower the serum carnitine concentration amongst the kwashiorkor children (r = 0.46; p < 0.01). There was a linear relationship between serum free carnitine and hiolein oxidation (r = 0.89; p < 0.001).
  
  
  CONCLUSIONS
  There is carnitine deficiency in kwashiorkor, and that the impaired lipid oxidation in kwashiorkor is related to this deficiency.
authors.affiliation: Department of Paediatrics, University of Transkei Medical School, Umtata, South Africa.
authors.forename: I
authors.initials: I
authors.lastname: Aseo
authors.forename: G
authors.initials: G
authors.lastname: Tindimwebwa
authors.forename: E
authors.initials: E
authors.lastname: Agu
authors.forename: J E
authors.initials: JE
authors.lastname: Iputo
mesh_terms: D001944:Breath Tests; D002331:Carnitine / Q000097:blood* / Q000172:deficiency*; D016022:Case-Control Studies; D002648:Child; D015362:Child Nutrition Disorders / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005215:Fasting; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D007732:Kwashiorkor / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D015596:Nutrition Assessment; D010084:Oxidation-Reduction; D015203:Reproducibility of Results; D015431:Weight Loss
chemical_list: D005227:Fatty Acids; D002331:Carnitine