title: Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
abstract: We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K-ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K-ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types.
authors.affiliation: Department of Medical Oncology, Clinica Puerta de Hierro, Madrid, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Garcia
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez
authors.forename: J M
authors.initials: JM
authors.lastname: Silva
authors.forename: G
authors.initials: G
authors.lastname: Dominguez
authors.forename: I S
authors.initials: IS
authors.lastname: Vegazo
authors.forename: C
authors.initials: C
authors.lastname: Gamallo
authors.forename: M
authors.initials: M
authors.lastname: Provencio
authors.forename: P
authors.initials: P
authors.lastname: España
authors.forename: F
authors.initials: F
authors.lastname: Bonilla
mesh_terms: D000328:Adult; D004252:DNA Mutational Analysis; D005091:Exons; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006338:Heart Neoplasms / Q000235:genetics*; D006394:Hemangiosarcoma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012208:Rhabdomyosarcoma / Q000235:genetics*