title: Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
abstract: Synthesis and biological evaluation of 6-thiophene 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives resulted in a number of potent nonsteroidal antiprogestins.
authors.affiliation: Ligand Pharmaceuticals, San Diego, CA 92121, USA. lzhi@ligand.com
authors.forename: L
authors.initials: L
authors.lastname: Zhi
authors.forename: C M
authors.initials: CM
authors.lastname: Tegley
authors.forename: B
authors.initials: B
authors.lastname: Pio
authors.forename: S J
authors.initials: SJ
authors.lastname: West
authors.forename: K B
authors.initials: KB
authors.lastname: Marschke
authors.forename: D E
authors.initials: DE
authors.lastname: Mais
authors.forename: T K
authors.initials: TK
authors.lastname: Jones
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D002460:Cell Line; D003429:Cross Reactions; D005347:Fibroblasts; D000882:Haplorhini; D006801:Humans; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors* / Q000235:genetics; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014162:Transfection; D014407:Tumor Cells, Cultured
chemical_list: D011804:Quinolines; D011980:Receptors, Progesterone; D013876:Thiophenes