[Progress in researches on the function of PML gene].
This paper was aimed to review and expound the progreses in studies on biological fuction of wild-type PML gene and hence to have a gain in knowledge about the carcinogenesis of PML-RARalpha protein. Related reports issued at home and abroad and some research results from this institute were collected and reviewed. According to the data collected PML gene has many biological activites. High expression of PML gene can inhibit the growth of cells and induce apoptosis; PML gene is possibly involved in the regulation of gene expression. Moreover, the function of PML gene is related to its three important domains and its nuclear location; PML gene is associated with carcinogenesis of APL.
Zhou
L
L
Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P.R.China.
Chen
G
G
Shen
Z
Z
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000209:etiology / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics* / Q000502:physiology; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D025521:Tumor Suppressor Proteins
D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D000071156:Promyelocytic Leukemia Protein; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; C070576:PML protein, human