title: Massive esophageal variceal hemorrhage triggered by complicated endotracheal intubation.
abstract: Esophageal variceal hemorrhage is frequently a catastrophic event. The specific events that trigger variceal rupture are not well understood. Acute elevations in systemic blood pressure and increased splanchnic blood flow, however, may lead to increased intravariceal pressure followed by variceal rupture and hemorrhage. This report describes a strong temporal association between complicated endotracheal intubation and abrupt onset of life-threatening variceal hemorrhage. A 52-year-old man with a history of portal hypertension was intubated emergently for airway protection because of respiratory insufficiency due to sepsis. Intubation was complicated by initial inadvertent esophageal intubation and by a peak mean arterial blood pressure of 155 mmHg. At the conclusion of the procedure, the patient sustained large volume hematemesis due to esophageal variceal rupture. This case suggests a risk of triggering variceal hemorrhage as a result of intubation-induced increase in blood pressure. A number of agents, including fentanyl, have been shown to be effective in attenuating the cardiovascular response to intubation. This case report provides strong evidence in support of administering fentanyl, or a suitable alternative adjunctive medication, before intubation of patients with documented portal hypertension and a history of esophageal variceal hemorrhage.
authors.affiliation: Medical Service, Pulmonary Section, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA.
authors.forename: W G
authors.initials: WG
authors.lastname: Kuschner
mesh_terms: D018450:Disease Progression; D004636:Emergency Service, Hospital; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D004945:Esophagoscopy; D017809:Fatal Outcome; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis / Q000503:physiopathology; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008104:Liver Cirrhosis, Alcoholic / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged