title: Changes in EEG power density during sleep laboratory adaptation in depressed inpatients.
abstract: BACKGROUND
  The aim of the present study was to evaluate the first-night effect in depressed inpatients, using standard sleep measures as well as all-night spectral analysis of the sleep electroencephalogram (EEG).
  
  
  METHODS
  Eighteen drug-free, depressed inpatients were studied for 3 consecutive nights in the hospital sleep laboratory.
  
  
  RESULTS
  Visual sleep scoring results showed a slight but measurable first-night effect, characterized by a reduction of rapid eye movement (REM) sleep amount and increased wakefulness. Sleep EEG spectral analysis showed significantly reduced delta (p <.01) and theta (p <.05) power density in non-REM (NREM) sleep of the first night compared with that of the second and third nights. These differences were limited to the early part of the sleep period, a time during the night that is particularly vulnerable to the effects of depressive disorder. In contrast to the NREM sleep findings, spectral REM variables studied did not significantly vary across the three nights.
  
  
  CONCLUSIONS
  The results obtained suggest that first-night data should not be simply discarded but could be used in subsequent analyses and could be considered useful in the evaluation of the sleep of depressed patients.
authors.affiliation: Foundation for Applied Neuroscience Research in Psychiatry (FORENAP) Centre Hospitalier, Rouffach, France.
authors.forename: M
authors.initials: M
authors.lastname: Toussaint
authors.forename: R
authors.initials: R
authors.lastname: Luthringer
authors.forename: L
authors.initials: L
authors.lastname: Staner
authors.forename: A
authors.initials: A
authors.lastname: Muzet
authors.forename: J
authors.initials: J
authors.lastname: Macher
mesh_terms: D000328:Adult; D015986:Confounding Factors, Epidemiologic; D003866:Depressive Disorder / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D012890:Sleep / Q000502:physiology*; D013053:Spectrophotometry; D013997:Time Factors