Effect of 3,6-dimethylpyrazine-2-thiol on androstenedione-induced increase of uterine weight in female rats.
3,6-Dimethylpyrazine-2-thiol administered at 10-70 mg/kg, p.o. was found to suppress androstenedione-induced increase of uterine weight in female rats. This action was weaker than that of aminoglutethimide (3-30 mg/kg, p.o.). After administration of androstenedione, increased plasma estradiol levels were reduced by 3,6-dimethylpyrazine-2-thiol. Moreover, in vitro, production of estradiol in the pregnant mare serum gonadotropin (PMSG)-treated ovary was inhibited by 3,6-dimethylpyrazine-2-thiol. These results suggest that 3,6-dimethylpyrazine-2-thiol has an inhibitory action on aromatase activity.
Yamada
K
K
Tokyo University of Pharmacy and Life Science, School of Pharmacy, Japan.
Sugawara
S
S
Ohmori
K
K
Ohta
A
A
D000616:Aminoglutethimide / Q000494:pharmacology; D000735:Androstenedione / Q000494:pharmacology*; D000818:Animals; D001141:Aromatase / Q000378:metabolism; D047072:Aromatase Inhibitors; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000031:analogs & derivatives; D014599:Uterus / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology
C101429:3,6-dimethylpyrazine-2-thiol; D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D011719:Pyrazines; D000616:Aminoglutethimide; D013739:Testosterone; D000735:Androstenedione; D001141:Aromatase