title: Determination of amylose/particulate relationship in hydroxyethylstarch.
abstract: Visual particulate was observed to form in parenteral hydroxyethylstarch over 24 months during stability studies. The particulate was identified as being amylose using FT-IR microscopy. Amylose values were measured in the bulk drug using the starch-iodine reaction. The amylose numbers measured in the bulk drug were found to correlate well with the measured particulate values in the parenteral formulation.
authors.affiliation: Abbott Laboratories, Hospital Products Division, Abbott Park, IL 60064-3500, USA.
authors.forename: D
authors.initials: D
authors.lastname: Stephens
authors.forename: D
authors.initials: D
authors.lastname: Bares
authors.forename: D
authors.initials: D
authors.lastname: Robinson
authors.forename: E
authors.initials: E
authors.lastname: Pec
mesh_terms: D000688:Amylose / Q000737:chemistry*; D004355:Drug Stability; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry*; D010316:Particle Size; D010952:Plasma Substitutes / Q000737:chemistry*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D000688:Amylose