title: Measles elimination--is it achievable? Lessons from an immunisation coverage survey.
abstract: OBJECTIVE
  To determine routine measles coverage at district level and to explore reasons for immunisation failure in Mpumalanga Province, South Africa.
  
  
  METHODS
  An adaptation of the World Health Organisation (WHO) Expanded Programme on Immunisation (EPI) cluster sampling method was used to make a random selection of 30 clusters in each of 21 health districts, 630 clusters in total. Seven individuals from the age group 12-23 months were randomly selected from each cluster and immunisation status and source were transcribed from their child health records. Where no immunisations were administered, reasons provided by parents or guardians were recorded.
  
  
  METHODS
  Mpumalanga Province, South Africa.
  
  
  RESULTS
  The weighted valid population coverage with measles vaccine for children aged 12-23 months in Mpumalanga Province was 71.1% (95% confidence interval 64.9-78.5%); this was the lowest of all EPI antigens. There was marked heterogeneity in measles coverage across the province, with a coefficient of variation of 22.2%. Districts with the lowest coverage shared borders with neighbouring provinces. District measles coverage was highly positively correlated with diphtheria, pertussis and tetanus (DPT3) coverage (r = 0.960, P = 0.000). There was a strong negative correlation between ranked measles campaign coverage and routine measles immunisation coverage. Obstacles to immunisation accounted for nearly half (49%) of all reasons for immunisation failure, while lack of information and lack of motivation accounted for 30% and 22%, respectively.
  
  
  CONCLUSIONS
  Survey results highlight the need for supplementary immunisation, including non-selective campaigns, if Mpumalanga is to achieve the South African goal of measles elimination by 2002. The value of determining district resolution coverage in order to identify areas with low measles coverage requiring supplementary intervention was also demonstrated. A strong negative correlation between routine and campaign coverage deserves further study in other settings.
authors.affiliation: Mpumalanga Department of Health, Nelspruit.
authors.forename: D N
authors.initials: DN
authors.lastname: Durrheim
authors.forename: G A
authors.initials: GA
authors.lastname: Ogunbanjo
mesh_terms: D003627:Data Interpretation, Statistical; D006801:Humans; D007223:Infant; D008457:Measles / Q000517:prevention & control*; D008458:Measles Vaccine; D011159:Population Surveillance; D013019:South Africa / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D008458:Measles Vaccine