Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins.
Physico-chemical properties of injectable polymeric implant systems, based on the principle that a water-insoluble polymer dissolved in a biocompatible solvent will precipitate upon contact with water, were studied and utilized to predict the release of proteins from these systems. Polylactide-co-glycolide copolymer (PLGA) and glycofurol were chosen since they both have pharmaceutical precedence. Changes in polymer composition, its weight percent in solution, molecular weight, and protein loading level were assessed to provide formulations with the desired release rates and duration of release.
Eliaz
R E
RE
Department of Chemical Engineering, Ben-Gurion University of the Negev, Beer-Sheba, 84105, Israel.
Kost
J
J
D000818:Animals; D001672:Biocompatible Materials; D016466:CHO Cells; D006224:Cricetinae; D016503:Drug Delivery Systems; D004343:Drug Implants; D019344:Lactic Acid; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D011506:Proteins / Q000008:administration & dosage
D001672:Biocompatible Materials; D004343:Drug Implants; D011108:Polymers; D011506:Proteins; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid