Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.
Synthesis and biological evaluation of 6-thiophene 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives resulted in a number of potent nonsteroidal antiprogestins.
Zhi
L
L
Ligand Pharmaceuticals, San Diego, CA 92121, USA. lzhi@ligand.com
Tegley
C M
CM
Pio
B
B
West
S J
SJ
Marschke
K B
KB
Mais
D E
DE
Jones
T K
TK
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D002460:Cell Line; D003429:Cross Reactions; D005347:Fibroblasts; D000882:Haplorhini; D006801:Humans; D051379:Mice; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors* / Q000235:genetics; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis* / Q000494:pharmacology; D014162:Transfection; D014407:Tumor Cells, Cultured
D011804:Quinolines; D011980:Receptors, Progesterone; D013876:Thiophenes