[Correlation between laminin and fibronectin on the basement membrane and tumor progression in early gastric cancer: an immunohistochemical study].
Using an immunohistochemical procedure, I studied the possible relationship between the distribution of the basement membrane glycoprotein laminin (LN) or fibronection (FN) and the histological type or the pattern of infiltrating growth into surrounding tissue of the superficial depressed-type early gastric cancer in 78 cases (mucosal cancer: 36 cases, submucosal cancer: 42 cases). The staining patterns of the basement membrane LN and FN were divided into continuous (C), discontinuous (D), and negative (N). The patterns of infiltrating growth into surrounding tissue were classified into expanding growth and infiltrating growth. In regard to the relationship between LN staining patterns and histological types, the frequency of C pattern was significantly high in tubular adenocarcinoma (51.9%) but none in poorly differentiated adenocarcinoma (0%). On the other hand, the frequency of N pattern was significantly lower in tubular adenocarcinoma (3.9%) than in poorly differentiated adenocarcinoma (61.5%). Also in regard to the relationship between FN staining patterns and histological types, similar results were observed. There was no significant relationship between the mucosal staining patterns of LN or FN and the depth of invasion. I compared the staining patterns between the mucosal lesions and the submucosal lesions in submucosal carcinoma. In regard to the relationship of LN staining, the frequency of N pattern was significantly lower in mucosal lesions than in submucosal lesions. There was no difference in patterns of FN staining between the mucosal lesions and the submucosal lesions. In regard to the relationship between the LN staining pattern and the pattern of infiltrating growth into surrounding tissue, the frequency of N pattern was significantly lower in expanding growth (23.5%) than in infiltrating growth (68.0%). There was no significant relationship between the FN staining pattern and the infiltrating growth pattern. These findings suggest that the disappearance of LN in gastric cancer is an important factor in the invasion of the submucosa or in determining the pattern of infiltrating growth of tumors into surrounding tissue.
Fujita
J
J
First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D001485:Basement Membrane / Q000378:metabolism / Q000473:pathology; D018450:Disease Progression; D005260:Female; D005353:Fibronectins / Q000032:analysis* / Q000502:physiology; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*
D005353:Fibronectins; D007797:Laminin