Poly(phthaloyl-L-lysine)-coated multilamellar vesicles for controlled drug delivery: in vitro and in vivo performance evaluation.
Nonionic surfactant vesicles were prepared using Span 60, cholesterol and dicetyl phosphate. The prepared multilamellar vesicles (MLVs) were coated by interfacial polymerization technique using p-phthaloyl dichloride and L-lysine. The formation of the polymeric coat was confirmed by optical microscopic and transmission electron microscopic studies. The prepared, plain and polymer-coated MLVs were studied for their size, shape, encapsulation efficiency, in vitro release profile and effect of osmotic shock on vesicle. The results observed showed that the polymer-coated MLVs were stable under various osmotic conditions. In vivo studies were carried out on albino rats. The half-life and area under curve were found to be high in the case of polymer-coated MLVs as compared to plain MLVs and plain drug solution. In vivo studies using inflammed rat model also indicated that the polymer-coated MLVs were more stable and could release the drug in a controlled fashion as compared to plain MLVs.
Vyas
S P
SP
spvyas@gwr1.dot.net.in
Venkatesan
N
N
D000818:Animals; D016503:Drug Delivery Systems; D005260:Female; D008297:Male; D009997:Osmotic Pressure; D010795:Phthalic Acids / Q000008:administration & dosage*; D011107:Polylysine / Q000008:administration & dosage*; D051381:Rats; D013501:Surface-Active Agents / Q000008:administration & dosage
D010795:Phthalic Acids; D013501:Surface-Active Agents; D011107:Polylysine; C059743:terephthaloyl chloride