title: Evaluation of intravenous flavopiridol formulations.
abstract: Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Arizona, Tucson, USA.
authors.forename: P
authors.initials: P
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Patel
authors.forename: S E
authors.initials: SE
authors.lastname: Tabibi
authors.forename: R
authors.initials: R
authors.lastname: Vishnuvajjala
authors.forename: S H
authors.initials: SH
authors.lastname: Yalkowsky
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000032:analysis*; D005419:Flavonoids / Q000008:administration & dosage / Q000032:analysis*; D007275:Injections, Intravenous; D019999:Pharmaceutical Solutions; D010880:Piperidines / Q000008:administration & dosage / Q000032:analysis*
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D019999:Pharmaceutical Solutions; D010880:Piperidines; C077990:alvocidib