Inclusion of piroxicam into beta-cyclodextrin by means of supercritical carbon dioxide: thermal, spectroscopic and physicochemical studies.
The preparation of a piroxicam-beta-cyclodextrin inclusion compound using supercritical CO2 was investigated. The solubility piroxicam in supercritical CO2 was determined. The influence of the temperature, the pressure and the time of exposure on the inclusion rate were studied and a complete inclusion was achieved by keeping a physical mixture of piroxicam and beta-cyclodextrin (1:2.5 mol/mol) for 6 hours at 150 degrees C and 150 bar of CO2. This complex was characterised by Differential Scanning Calorimetry and Fourier Transform Infrared Spectrometry. Supercritical carbon dioxide may prove to be a novel useful complexation method of non-polar drugs into beta-cyclodextrin.
Van Hees
T
T
Department of Pharmaceutical Technology, Institute of Pharmacy, CHU, Liége, Belgium.
Evrard
B
B
Piel
G
G
Delattre
L
L
D002245:Carbon Dioxide / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003505:Cyclodextrins; D010894:Piroxicam / Q000737:chemistry*; D012995:Solubility; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D010894:Piroxicam; D002245:Carbon Dioxide; C031215:betadex