title: Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200.
abstract: A novel strategy for solid-phase synthesis of hydantoins with high optical purity is described using a thermal pH-neutral cyclization and simultaneous release from resin. Hereby even hydantoins bearing a pH-sensitive side chain (protection) are available. The reaction conditions are well screened applying the parallel organic synthesizer APOS 1200.
authors.affiliation: Rapp Polymere GmbH, Tübingen, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Karnbrock
authors.forename: M
authors.initials: M
authors.lastname: Deeg
authors.forename: J
authors.initials: J
authors.lastname: Gerhardt
authors.forename: W
authors.initials: W
authors.lastname: Rapp
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D008401:Gas Chromatography-Mass Spectrometry; D006827:Hydantoins / Q000138:chemical synthesis* / Q000302:isolation & purification; D006863:Hydrogen-Ion Concentration; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D010455:Peptides / Q000138:chemical synthesis; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D000596:Amino Acids; D006827:Hydantoins; D010455:Peptides; D014867:Water; D000432:Methanol