title: 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents.
abstract: 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, South Korea. ckryu@mm.ewha.ac.kr
authors.forename: C K
authors.initials: CK
authors.lastname: Ryu
authors.forename: H Y
authors.initials: HY
authors.lastname: Kang
authors.forename: S K
authors.initials: SK
authors.lastname: Lee
authors.forename: K A
authors.initials: KA
authors.lastname: Nam
authors.forename: C Y
authors.initials: CY
authors.lastname: Hong
authors.forename: W G
authors.initials: WG
authors.lastname: Ko
authors.forename: B H
authors.initials: BH
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D011518:Proto-Oncogene Proteins; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D011518:Proto-Oncogene Proteins; D013844:Thiazoles; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases