[Reactivity of blood vessels in vitro: the role of perfusate pH and the initial tone of myocytes].
In the rat mesenteric artery ring, acidic solution (pH 7.0) inhibited the electrical field stimulation (EFS)-evoked response in a wide range of stretch. Acidosis potentiated the EFS-evoked constriction of the ring precontracted with 0.5 mu noradrenaline. The EFS dilated rings precontracted with 0.7 mu noradrenaline in control solution but contracted it in the acidic solution. Tone-dependent mechanisms of the acidosis effects on the EFS-evoked responses are discussed.
Iartsev
V N
VN
I.P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Nab. Makarova, 6, Russia.
Karachentseva
O V
OV
Dvoretskiĭ
D P
DP
D000818:Animals; D004558:Electric Stimulation; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000166:cytology / Q000502:physiology; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D014662:Vasoconstrictor Agents; D009638:Norepinephrine