title: Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2.
abstract: OBJECTIVE
  The aim of this study was to examine the effect of periodontal surgery on PGE2 levels in patients treated for advanced adult periodontitis, with and without application of a 25% metronidazole gel over 12 months follow-up.
  
  
  METHODS
  The trial employed a randomised controlled, single-blind, parallel arm design on 43 patients with at least 1 pocket probing > or =6 mm with bleeding on probing (BOP).
  
  
  RESULTS
  The results showed that GCF PGE2 levels showed no significant change following surgical therapy despite marked improvements in clinical periodontal health (p=0.653). No significant differences in the reaction of sites to treatment were detected between test and control groups throughout the study (p=0.709). However, PGE2 levels in GCF were significantly higher in experimental sites compared with healthy untreated sites (negative controls) in both surgery only (p= 0.001) and surgery+gel (p=0.023) groups throughout the study.
  
  
  CONCLUSIONS
  Whilst clear differences were observed between healthy control sites and sites with periodontal breakdown, no effect of treatment on PGE2 levels was discernible in this study.
authors.affiliation: Department of Periodontology, Eastman Dental Institute for Oral Healthcare Sciences, University College London, University of London, UK. i.needleman@eastman.ucl.ac.uk
authors.forename: I G
authors.initials: IG
authors.lastname: Needleman
authors.forename: D R
authors.initials: DR
authors.lastname: Moles
authors.forename: A M
authors.initials: AM
authors.lastname: Collins
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016001:Confidence Intervals; D015232:Dinoprostone / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005500:Follow-Up Studies; D005782:Gels; D005883:Gingival Crevicular Fluid / Q000737:chemistry*; D005884:Gingival Hemorrhage / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D010510:Periodontal Diseases / Q000188:drug therapy / Q000601:surgery*; D010514:Periodontal Pocket / Q000188:drug therapy / Q000601:surgery; D010518:Periodontitis / Q000188:drug therapy / Q000601:surgery; D016037:Single-Blind Method; D013524:Surgical Flaps
chemical_list: D000890:Anti-Infective Agents; D005782:Gels; D008795:Metronidazole; D015232:Dinoprostone