title: Saline infusion sonohysterography in endometrial cancer: assessment of malignant cells dissemination risk.
abstract: BACKGROUND
  To assess the risk of malignant cells dissemination in patients with endometrial cancer undergoing saline infusion sonohysterography (SIS).
  
  
  METHODS
  Fourteen consecutive patients (mean age: 58.1 years, range: 41-74 years) diagnosed as having a clinical stage I endometrial carcinoma and scheduled for surgical staging were entered in this study. SIS was performed at the time of laparotomy just when the abdomen was opened and prior to the start of the surgical procedure. 10-20 mL of saline was infused. All fluid spilled from the fimbrial ends of the fallopian tubes was collected and analyzed for the presence or absence of malignant endometrial cells. Samplings were also taken from ascites, if found, or cytological washings, prior to and after SIS.
  
  
  RESULTS
  SIS could be satisfactorily performed in all patients. There was no spillage from either tube in nine patients. Mean fluid volume obtained from the other five patients was 4.4 mL. Cytologic analysis revealed the presence of malignant cells in the spilled fluid in one case (7.1%, one out of fourteen).
  
  
  CONCLUSIONS
  Our data show that a small but real risk of malignant cell dissemination exists in patients with endometrial carcinoma who undergo SIS.
authors.affiliation: Department of Obstetrics and Gynecology, Clínica Universitaria de Navarra, Faculty of Medicine, University of Navarre, Pamplona, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Alcázar
authors.forename: T
authors.initials: T
authors.lastname: Errasti
authors.forename: A
authors.initials: A
authors.lastname: Zornoza
mesh_terms: D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005187:Fallopian Tubes / Q000166:cytology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging / Q000379:methods; D018570:Risk Assessment; D012965:Sodium Chloride / Q000008:administration & dosage* / Q000009:adverse effects*; D014463:Ultrasonography / Q000009:adverse effects*; D014599:Uterus / Q000166:cytology / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D012965:Sodium Chloride