title: Improvement of disseminated lymphangiomatosis with recombinant interferon therapy.
abstract: Disseminated lymphangiomatosis is a rare disorder with a poor prognosis. We present a case involving a 3-year-old boy who presented with pulmonary infiltrates, multiple lytic lesions of the ribcage, and small cystic lesions in the spleen. Open-lung and bone biopsies revealed disseminated lymphangiomatosis. Significant clinical and radiologic improvement were observed and persisted after 28 months of treatment with recombinant interferon alpha-2b (IFN alpha-2b). No significant toxicity has been observed.
authors.affiliation: Section of Hematology/Oncology, Division of Pediatrics, Ste-Justine Hospital, University of Montreal, Montreal, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Laverdière
authors.forename: M
authors.initials: M
authors.lastname: David
authors.forename: J
authors.initials: J
authors.lastname: Dubois
authors.forename: P
authors.initials: P
authors.lastname: Russo
authors.forename: L
authors.initials: L
authors.lastname: Hershon
authors.forename: J G
authors.initials: JG
authors.lastname: Lapierre
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D018192:Lymphangioleiomyomatosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D008297:Male; D011994:Recombinant Proteins; D014057:Tomography, X-Ray Computed
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins