title: Assessment of nonuniformity of transmural myocardial velocities by color-coded tissue Doppler imaging: characterization of normal, ischemic, and stunned myocardium.
abstract: BACKGROUND
  Transmural myocardial contractile performance is nonuniform across the different layers of the left ventricular wall. We evaluated the accuracy of color M-mode tissue Doppler imaging (TDI) to assess the transmural distribution of myocardial velocities and to quantify the severity of dysfunction induced by acute ischemia and reperfusion in the inner and outer myocardial layers.
  
  
  RESULTS
  Thirteen open-chest dogs underwent 15 minutes of left anterior descending coronary artery occlusion followed by 120 minutes of reperfusion. M-mode TDI was obtained from an epicardial short-axis view. Systolic velocities were calculated within endocardium and epicardium of the anterior and posterior walls. Regional myocardial blood flow was assessed by radioactive microspheres. Segment shortening was measured by sonomicrometry in endocardium and epicardium of both the anterior and posterior walls. At baseline, endocardial velocities were higher than epicardial velocities, resulting in an inner/outer myocardial velocity gradient. Ischemia caused a significant and comparable reduction in endocardial and epicardial systolic velocities in the anterior wall with the disappearance of the velocity gradient. Systolic velocities significantly correlated with segment shortening in both endocardium and epicardium during ischemia and reperfusion. In the first minutes after reflow, endocardial velocities showed a greater improvement than epicardial velocities, and the velocity gradient resumed although to a limited extent, indicative of stunning.
  
  
  CONCLUSIONS
  TDI is an accurate method to assess the nonuniformity of transmural velocities and may be a promising new tool for quantifying ischemia-induced regional myocardial dysfunction.
authors.affiliation: CHU de Rouen, Rouen, and Laboratoire de Physiologie Lyon-Nord, Lyon-Nord, France. Genevieve.Dermeaux@chu-rouen.fr
authors.forename: G
authors.initials: G
authors.lastname: Derumeaux
authors.forename: M
authors.initials: M
authors.lastname: Ovize
authors.forename: J
authors.initials: J
authors.lastname: Loufoua
authors.forename: G
authors.initials: G
authors.lastname: Pontier
authors.forename: X
authors.initials: X
authors.lastname: André-Fouet
authors.forename: A
authors.initials: A
authors.lastname: Cribier
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D004285:Dogs; D018618:Echocardiography, Doppler, Color; D006439:Hemodynamics / Q000502:physiology; D009200:Myocardial Contraction / Q000502:physiology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D016276:Ventricular Function