title: Homozygosity mapping of the locus responsible for renal tubular dysplasia of cattle on bovine chromosome 1.
abstract: Renal tubular dysplasia is a hereditary disease of Japanese black cattle showing renal failure and growth retardation with an autosomal recessive trait. In the present study, we mapped the locus responsible for the disease (RTD) by linkage analysis with an inbred paternal half-sib pedigree obtained from commercial herds. By analyzing segregation of microsatellite markers in the half-sibs, significant linkage was observed between the RTD locus and markers on bovine Chromosome (Chr) 1 with the highest lod score of 11.4. Homozygosity mapping with the inbred pedigree further defined the localization of the RTD locus in a 4-cM region between microsatellite markers BMS4003 and INRA119. Mapping of the RTD locus on bovine Chr 1 will facilitate cloning and characterization of the gene responsible for this disease.
authors.affiliation: Division of Veterinary Medicine, Faculty of Agriculture, Gifu University, Yanagido, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ohba
authors.forename: H
authors.initials: H
authors.lastname: Kitagawa
authors.forename: K
authors.initials: K
authors.lastname: Kitoh
authors.forename: S
authors.initials: S
authors.lastname: Asahina
authors.forename: K
authors.initials: K
authors.lastname: Nishimori
authors.forename: K
authors.initials: K
authors.lastname: Yoneda
authors.forename: T
authors.initials: T
authors.lastname: Kunieda
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D002417:Cattle; D002874:Chromosome Mapping / Q000662:veterinary*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006720:Homozygote; D007684:Kidney Tubules / Q000002:abnormalities*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D010375:Pedigree
chemical_list: D005819:Genetic Markers