title: Comparative genomics of the eukaryotes.
abstract: A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
authors.affiliation: Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Berkeley Drosophila Genome Project, University of California, Berkeley, CA 94720, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
authors.forename: M D
authors.initials: MD
authors.lastname: Yandell
authors.forename: J R
authors.initials: JR
authors.lastname: Wortman
authors.forename: G L
authors.initials: GL
authors.lastname: Gabor Miklos
authors.forename: C R
authors.initials: CR
authors.lastname: Nelson
authors.forename: I K
authors.initials: IK
authors.lastname: Hariharan
authors.forename: M E
authors.initials: ME
authors.lastname: Fortini
authors.forename: P W
authors.initials: PW
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Apweiler
authors.forename: W
authors.initials: W
authors.lastname: Fleischmann
authors.forename: J M
authors.initials: JM
authors.lastname: Cherry
authors.forename: S
authors.initials: S
authors.lastname: Henikoff
authors.forename: M P
authors.initials: MP
authors.lastname: Skupski
authors.forename: S
authors.initials: S
authors.lastname: Misra
authors.forename: M
authors.initials: M
authors.lastname: Ashburner
authors.forename: E
authors.initials: E
authors.lastname: Birney
authors.forename: M S
authors.initials: MS
authors.lastname: Boguski
authors.forename: T
authors.initials: T
authors.lastname: Brody
authors.forename: P
authors.initials: P
authors.lastname: Brokstein
authors.forename: S E
authors.initials: SE
authors.lastname: Celniker
authors.forename: S A
authors.initials: SA
authors.lastname: Chervitz
authors.forename: D
authors.initials: D
authors.lastname: Coates
authors.forename: A
authors.initials: A
authors.lastname: Cravchik
authors.forename: A
authors.initials: A
authors.lastname: Gabrielian
authors.forename: R F
authors.initials: RF
authors.lastname: Galle
authors.forename: W M
authors.initials: WM
authors.lastname: Gelbart
authors.forename: R A
authors.initials: RA
authors.lastname: George
authors.forename: L S
authors.initials: LS
authors.lastname: Goldstein
authors.forename: F
authors.initials: F
authors.lastname: Gong
authors.forename: P
authors.initials: P
authors.lastname: Guan
authors.forename: N L
authors.initials: NL
authors.lastname: Harris
authors.forename: B A
authors.initials: BA
authors.lastname: Hay
authors.forename: R A
authors.initials: RA
authors.lastname: Hoskins
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: R O
authors.initials: RO
authors.lastname: Hynes
authors.forename: S J
authors.initials: SJ
authors.lastname: Jones
authors.forename: P M
authors.initials: PM
authors.lastname: Kuehl
authors.forename: B
authors.initials: B
authors.lastname: Lemaitre
authors.forename: J T
authors.initials: JT
authors.lastname: Littleton
authors.forename: D K
authors.initials: DK
authors.lastname: Morrison
authors.forename: C
authors.initials: C
authors.lastname: Mungall
authors.forename: P H
authors.initials: PH
authors.lastname: O'Farrell
authors.forename: O K
authors.initials: OK
authors.lastname: Pickeral
authors.forename: C
authors.initials: C
authors.lastname: Shue
authors.forename: L B
authors.initials: LB
authors.lastname: Vosshall
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: Q
authors.initials: Q
authors.lastname: Zhao
authors.forename: X H
authors.initials: XH
authors.lastname: Zheng
authors.forename: S
authors.initials: S
authors.lastname: Lewis
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D005075:Biological Evolution; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D002448:Cell Adhesion / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D004331:Drosophila melanogaster / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics; D020131:Genes, Duplicate; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005826:Genetics, Medical; D016678:Genome; D015801:Helminth Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007109:Immunity / Q000235:genetics; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics; D017434:Protein Structure, Tertiary; D020543:Proteome; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics
chemical_list: D005656:Fungal Proteins; D015801:Helminth Proteins; D019476:Insect Proteins; D020543:Proteome