title: Natural killer cell numbers and cytotoxic activity in pediatric Hodgkin disease.
abstract: In this study peripheral blood natural killer (NK) cell activity was evaluated in 17 pediatric cases with Hodgkin disease (HD) (9 untreated, 8 in remission) and 20 age-matched healthy children. Peripheral blood CD16 and CD56 molecule expressions were also examined. No difference related to NK cell numbers and cytotoxic activity was detected at either stage of the disease. In cases in which long-term remission has been achieved (> or = 5 years) NK cell activity was slightly but not significantly increased in parallel with remission duration. Finally, no relation between NK cell activity and the etiology, prognosis, and severity of the disease has been established in children with HD.
authors.affiliation: Department of Pediatric Immunology-Allergy, Ankara University Medical School, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Ikincioğullari
authors.forename: F
authors.initials: F
authors.lastname: Doğu
authors.forename: E
authors.initials: E
authors.lastname: Babacan
authors.forename: G
authors.initials: G
authors.lastname: Oflaz
authors.forename: U
authors.initials: U
authors.lastname: Ertem
authors.forename: G
authors.initials: G
authors.lastname: Yavuz
authors.forename: E
authors.initials: E
authors.lastname: Unal
authors.forename: S
authors.initials: S
authors.lastname: Gözdaşoğlu
authors.forename: N
authors.initials: N
authors.lastname: Taçyildiz
authors.forename: A
authors.initials: A
authors.lastname: Dağdemir
authors.forename: A O
authors.initials: AO
authors.lastname: Cavdar
mesh_terms: D000293:Adolescent; D000328:Adult; D019002:CD56 Antigen / Q000097:blood; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D003602:Cytotoxicity, Immunologic; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism / Q000473:pathology; D008297:Male; D017452:Receptors, IgG / Q000097:blood; D014421:Turkey / Q000453:epidemiology
chemical_list: D019002:CD56 Antigen; D017452:Receptors, IgG