3-Nitropropionic acid preconditioning ameliorates delayed neurological deterioration and infarction after transient focal cerebral ischemia in gerbils.
The effect of 3-nitropropionic acid (3-NP), a selective inhibitor of succinic dehydrogenase, preconditioning on postischemic neurological deterioration and infarction was examined in gerbils after transient ischemia. The animals were pretreated with 1-80mg/kg of 3-NP 1 day before ischemia induced by two 10-min occlusions of the left common carotid artery. Four milligrams per kilogram 3-NP pretreatment significantly ameliorated postischemic neurological deterioration (stroke index at 7 days postischemia, 1.4+/-1.5 vs. 7.4+/-5.4 in 4 mg/kg-pretreated vs. non-pretreated animals: mean+/-SD) and reduced infarct volume (24+/-4.8 vs. 43+/-12 mm(3)). One and 20 mg/kg 3-NP induced milder neuroprotection, and 80 mg/kg 3-NP aggravated postischemic stroke symptoms and infarction. Thus, appropriate doze of 3-NP preconditioning is effective in ameliorating the postischemic neurological deterioration and reducing infarct volume.
Kuroiwa
T
T
Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, Japan.t.kuriowa.npat@mri1.tmd.ac.jp
Yamada
I
I
Endo
S
S
Hakamata
Y
Y
Ito
U
U
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D017536:Carotid Artery, Common; D002544:Cerebral Infarction / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D019194:Ischemic Preconditioning; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D009574:Nitro Compounds; D011422:Propionates / Q000494:pharmacology*
D000959:Antihypertensive Agents; D009574:Nitro Compounds; D011422:Propionates; C015392:3-nitropropionic acid