title: Ambulatory blood pressure and neuroendocrine control after diet-assisted gastric restrictive surgery.
abstract: BACKGROUND
  Long-term weight control after conventional diet is disappointing but may be improved when diet is assisted by gastric restrictive surgery (GRS).
  
  
  OBJECTIVE
  To determine the effects of GRS on ambulatory blood pressure (ABP) and neuroendocrine BP control in 28 morbidly obese subjects.
  
  
  METHODS
  A BP and heart rate were recorded every 10 min for 25 h before and 4 months after GRS. Effects of marked reductions in body weight on the renin-angiotensinaldosterone system, on plasma insulin and on sympathetic activity were also determined.
  
  
  RESULTS
  Body mass index decreased from 43 +/- 1 to 34 +/- 1 kg/m2 and systolic (S) BP decreased by 7 +/- 2 mmHg during daytime (P=0.01) and by 8 +/- 3 mmHg during the night (P=0.02). Pulse pressure, a marker of reduced arterial compliance, decreased by 5 +/- 1 mmHg throughout the 24 h period (P < 0.001). Diastolic BP remained unchanged. Heart rate decreased more during the night (-13 +/- 2 bpm, P<0.0001) than during daytime (-5 +/- 2 bpm, P=0.03). Reductions in SBP were largest in subjects with highest initial BP values (r = -0.63, P<0.001) but were unrelated to weight loss. GRS decreased fasting glycaemia, plasma insulin, plasma C peptide and 24 h urine sodium (n=20) and noradrenaline (n=19) excretion (P<0.01).
  
  
  CONCLUSIONS
  Diet-assisted GRS favourably affects neuroendocrine BP control in obese patients. Reductions in sodium intake, insulin levels and sympathetic tone combined with possible improvements in arterial compliance induce persistent 24 h reductions in SBP and pulse BP. Reductions in BP are largest in subjects with highest initial BP values and are unrelated to the amount of weight loss, thereby emphasizing the importance of even moderate reductions in weight on BP control.
authors.affiliation: Hypertension Clinic, Erasme Hospital, Brussels, Belgium. pvandebo@ulb.ac.be
authors.forename: P
authors.initials: P
authors.lastname: van de Borne
authors.forename: I
authors.initials: I
authors.lastname: Watrin
authors.forename: M
authors.initials: M
authors.lastname: Bouquegneau
authors.forename: A
authors.initials: A
authors.lastname: Gilles
authors.forename: J J
authors.initials: JJ
authors.lastname: Houben
authors.forename: F
authors.initials: F
authors.lastname: Fery
authors.forename: J P
authors.initials: JP
authors.lastname: Degaute
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D001823:Body Composition; D001835:Body Weight; D004038:Diet, Reducing; D013505:Digestive System Surgical Procedures; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D009490:Neurosecretory Systems / Q000503:physiopathology*; D009767:Obesity, Morbid / Q000178:diet therapy* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies