title: Rapid attainment of steady-state plasma drug concentrations within precise limits in multicompartment mammillary systems.
abstract: We have previously described a method of rapidly obtaining a specified steady-state plasma concentration of an intravenous drug within precise limits. However the method is limited to drugs whose disposition may be characterized by an open two-compartment system. In this paper, we illustrate how the method can be extended to drugs whose disposition may be characterized by a mammillary model with any number of compartments. Refinements of our previous technique are also described.
authors.affiliation: Department of Anaesthesia, Royal Perth Hospital, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Korman
authors.forename: L S
authors.initials: LS
authors.lastname: Jennings
mesh_terms: D000776:Anesthesiology / Q000379:methods; D000818:Animals; D007262:Infusions, Intravenous; D008954:Models, Biological; D010599:Pharmacokinetics