title: Lubricant susceptibility of Cellactose and Avicel PH-200: a quantitative relationship.
abstract: The lubricant susceptibility of two direct compression excipients, Avicel PH-200 and Cellactose, was determined using a model mix with metamizol sodium (dipyrone) and designed experiments to obtain a quantitative relationship by multiple regression. As a result, a new constant called specific lubricant sensibility Ls is proposed for the comparison of lubricant susceptibility in other drug-excipient systems.
authors.affiliation: Section of Pharmaceutical Technology, Facultad de Estudios Superiores Cuautitlan UNAM, México.
authors.forename: L
authors.initials: L
authors.lastname: Estrada Flores
authors.forename: R
authors.initials: R
authors.lastname: López Arellano
authors.forename: J J
authors.initials: JJ
authors.lastname: Díaz Esquivel
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D005079:Excipients / Q000737:chemistry*; D008153:Lubrication; D012044:Regression Analysis
chemical_list: D005079:Excipients; D002482:Cellulose