Transformation of the sydnone ring into oxadiazolinones. A convenient one-pot synthesis of 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones from 3-arylsydnones and their antimicrobial activity.
3-Arylsydnones (Ia-u) have been converted into the corresponding 3-aryl-5-methyl-1,3,4-oxadiazolin-2-ones (IIIa-u) by a single-step reaction with bromine in acetic anhydride. In the preliminary screening of all these compounds, the halogen-substituted derivatives have shown antimicrobial activities equal to those of the standard drugs used.
Mallur
S G
SG
Post-Graduate Department of Studies in Chemistry, Karnatak University, Dharwad, India.
Badami
B V
BV
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013558:Sydnones / Q000737:chemistry*
D000890:Anti-Infective Agents; D010069:Oxadiazoles; D013558:Sydnones