title: White matter abnormalities in mobility-impaired older persons.
abstract: OBJECTIVE
  To investigate the relationship between white matter abnormalities and impairment of gait and balance in older persons.
  
  
  METHODS
  Quantitative MRI was used to evaluate the brain tissue compartments of 28 older individuals separated into normal and impaired groups on the basis of mobility performance testing using the Short Physical Performance Battery. In addition, individuals were tested on six indices of gait and balance. For imaging data, segmentation of intracranial volume into four tissue classes was performed using template-driven segmentation, in which signal-intensity-based statistical tissue classification is refined using a digital brain atlas as anatomic template.
  
  
  RESULTS
  Both decreased white matter volume, which was age-related, and increased white matter signal abnormalities, which were not age-related, were observed in the mobility-impaired group compared with the control subjects. The average volume of white matter signal abnormalities for impaired individuals was nearly double that of control subjects.
  
  
  CONCLUSIONS
  This cross-sectional study suggests that decreased white matter volume is age-related, whereas increased white matter signal abnormalities are most likely to occur as a result of disease. Both of these changes are independently associated with impaired mobility in older persons and therefore likely to be additive factors of motor disability.
authors.affiliation: Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. guttmann@bwh.harvard.edu
authors.forename: C R
authors.initials: CR
authors.lastname: Guttmann
authors.forename: R
authors.initials: R
authors.lastname: Benson
authors.forename: S K
authors.initials: SK
authors.lastname: Warfield
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.forename: M C
authors.initials: MC
authors.lastname: Anderson
authors.forename: C B
authors.initials: CB
authors.lastname: Hall
authors.forename: K
authors.initials: K
authors.lastname: Abu-Hasaballah
authors.forename: J P
authors.initials: JP
authors.lastname: Mugler
authors.forename: L
authors.initials: L
authors.lastname: Wolfson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000473:pathology* / Q000503:physiopathology; D004856:Postural Balance / Q000502:physiology