Octylcyanoacrylate versus polyurethane for treatment of burns in swine: a randomized trial.
In order to determine whether the enhanced reepithelialization of second-degree burns treated with octylcyanoacrylate (OCA) was due to its occlusive nature we compared reepithelialization (REP) and infection rates of second degree burns treated with OCA and polyurethane film (Tegaderm) in swine. Forty-four standardized partial thickness burns were created by applying an aluminum bar preheated to 80 degrees C to the backs of pigs for 20 s and randomly treated with OCA or Tegaderm. Full thickness biopsies were taken at 7, 10 and 14 days for blinded histopathological evaluation of rates of infection and reepithelialization. T-tests and chi(2) tests were used for group comparisons. There were no between group difference in the rates of reepithelialization and infection. All wounds were reepithelialized by day 14 and there were no infections in either group. We conclude that treatment of partial thickness burns with OCA spray or Tegaderm results in similar rates of reepithelialization and infection, suggesting that the beneficial effects of OCA on reepithelialization are due to its occlusive nature.
Singer
A J
AJ
Department of Emergency Medicine, University Hospital and Medical Center, State University of New York, L4-515, Stony Brook, NY 11794-7400, USA.
Mohammad
M
M
Thode
H C
HC
McClain
S A
SA
D000818:Animals; D001706:Biopsy; D002056:Burns / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D016009:Chi-Square Distribution; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004848:Epithelium / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D009779:Occlusive Dressings; D011140:Polyurethanes / Q000627:therapeutic use*; D011897:Random Allocation; D015203:Reproducibility of Results; D016037:Single-Blind Method; D012867:Skin / Q000473:pathology / Q000503:physiopathology; D013552:Swine; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D014946:Wound Infection / Q000209:etiology
D003487:Cyanoacrylates; D011140:Polyurethanes; D014014:Tissue Adhesives; C119247:octylcyanoacrylate