Carbamazepine-induced Stevens-Johnson syndrome treated with IV steroids and IVIG.
A 17-year-old female is presented who developed antiepileptic drug hypersensitivity syndrome after treatment with carbamazepine. The initial diagnoses were idiopathic thrombocytopenic purpura and toxic shock syndrome. The patient was treated with intravenous immunoglobulin and intravenous steroids. After a severe climax on days 2-4 she recovered completely and was discharged on the eighth day of hospitalization. Although we do not have direct proof, we believe that these treatment modalities, especially the IVIG, shortened and ameliorated the clinical course of the disease.
Straussberg
R
R
Department Pediatrics "C", Schneider Children's Medical Center of Israel, Sackler School of Medicine, Tel Aviv University, Israel.
Harel
L
L
Ben-Amitai
D
D
Cohen
D
D
Amir
J
J
D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D007262:Infusions, Intravenous; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced / Q000188:drug therapy*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D016756:Immunoglobulins, Intravenous; D002220:Carbamazepine; D008775:Methylprednisolone