title: Clinical and histopathologic characteristics of trichrome vitiligo.
abstract: BACKGROUND
  The term trichrome vitiligo describes lesions that have a tan zone of varying width between normal and totally depigmented skin, which exhibits an intermediate hue. However, the pathogenesis and the histopathologic characteristics of trichrome vitiligo are unknown.
  
  
  OBJECTIVE
  Our purpose was to investigate the clinical and histopathologic characteristics and the pathogenesis of trichrome vitiligo.
  
  
  METHODS
  Four punch biopsy specimens were taken from 21 patients with trichrome vitiligo; they were from vitiliginous skin, light brown skin, perilesional normal skin, and normal skin as far as 5 cm from the nearest vitiligo spot. The sections were stained with hematoxylin-eosin; in selected cases, we performed immunohistochemical staining with S-100 protein and CD1a.
  
  
  RESULTS
  Trichrome vitiligo occurred most frequently on the trunk in active vitiligo vulgaris. Focal vacuolar degeneration of the basal cell layer and mild inflammatory cell infiltration of the epidermis and dermis were more prominent in light brown skin and perilesional normal skin than in vitiliginous skin and normal skin. The number of melanocytes was decreased in light brown skin compared with perilesional normal skin (P <.05) and in vitiliginous skin compared with light brown skin (P <.05); a few melanocytes were observed even in skin affected by trichrome vitiligo. The number of Langerhans cells was increased in the epidermis of light brown skin and perilesional normal skin compared with vitiliginous and normal skin (P <.05). PUVA therapy yielded excellent repigmentation.
  
  
  CONCLUSIONS
  Trichrome vitiligo is a variant of active vitiligo. The changes of melanocytes, keratinocytes, and Langerhans cells may be involved in the pathogenesis of depigmentation in trichrome vitiligo.
authors.affiliation: Department of Dermatology, Yonsei University College of Medicine, and the Pochon CHA Medical College, Pundang CHA Hospital. skhann@hitel.net
authors.forename: S K
authors.initials: SK
authors.lastname: Hann
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: J H
authors.initials: JH
authors.lastname: Yoo
authors.forename: Y S
authors.initials: YS
authors.lastname: Chun
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D008297:Male; D011701:PUVA Therapy; D012867:Skin / Q000473:pathology*; D012880:Skin Pigmentation; D014820:Vitiligo / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology