Cytologic appearances in invasive lobular carcinoma of the breast. A study of 21 cases.
OBJECTIVE
To examine the fine needle aspiration cytologic features of invasive lobular carcinoma of breast and to discuss problems that may occur in cytodiagnosis.


METHODS
Fine needle aspiration cytologic smears from 21 cases of invasive lobular carcinoma (ILC) of breast were subjected to detailed cytomorphologic analysis. Features studied included pattern of cells, size of cells, nuclear placement, pleomorphism, presence of intracytoplasmic lumina (ICL) and signet ring cells.


RESULTS
Cellularity was generally moderate or high, and the pattern was predominantly or partly dissociated in 86% of cases. Rosettelike pattern was discerned in alveolar-type ILC. Cell size was usually small or intermediate, with nuclei placed eccentrically in most cases. ICLs with or without signet ring cells were present in 12 cases (57%).


CONCLUSIONS
A cytologic picture consisting of predominantly dissociated small or intermediate-sized tumor cells with eccentric nuclei, with some of the cells showing ICLs, is highly suggestive of ILC. Indian file pattern, another characteristic feature of ILC, is, however, focal and inconsistent. Variant patterns of ILC may show other cytologic features, such as rosettelike pattern (alveolar variant of ILC) or large cell pattern (pleomorphic variant of ILC) and may consequently be difficult to categorize on cytologic smears.
Jayaram
G
G
Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Swain
M
M
Chew
M T
MT
Yip
C H
CH
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000145:classification / Q000473:pathology* / Q000601:surgery; D002467:Cell Nucleus / Q000473:pathology; D048429:Cell Size; D003581:Cytodiagnosis; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged