title: Are pulmonary homografts which were subjected to pulmonary hypertension more appropriate for aortic valve replacement than normal pulmonary homografts? A long-term multicentric echography study.
abstract: OBJECTIVE
  To compare long-term results of the European Homograft Bank (LHB) cryopreserved pulmonary homograft in left ventricular outflow tract (LVOT) subjected to pulmonary hypertension with those subjected to normal pulmonary pressure. The mid-term study of this material published in 1997 showed different results.
  
  
  METHODS
  Statistical analysis is calculated by the Kaplan-Meier survival curves, while differences in prevalence by the Log-Rank test.
  
  
  RESULTS
  Follow-up (FU) was available in 69 cases (76.7%): 46 in group 1 and 23 in group 2. Five patients have been excluded from the study because of early homograft explantation (technical problems or early valve incompetence). Fourteen out of 43 cases of group 1 (32. 6%) and seven out of 21 cases of group 2 (33.3%) have been explanted after 2.5-88 months and 7-88 months, respectively. Significant echography changes have been found in 19 of 43 (44.18%) of group 1 and 11 of 21 cases (52.38%) of group 2 during the follow-up. Histology showed essentially wear and tear induced lesions. Mean FU was 36.9 (range, 6-88) and 41.3 months (range, 4-88) for group 1 and 2, respectively. No significant difference in the long-term outcome have been found between the two groups (P=0.38).
  
  
  CONCLUSIONS
  Contrary to our previous echocardiography study of mid-term implants the long-term follow up of the PHGs implanted in the LVOT did not show better function of the pulmonary homografts subjected to pulmonary hypertension than those with normal pulmonary pressure. The high failure rate of the PHGs should discourage their use for LVOT reconstruction. Further echocardiography studies of remaining PHGs implanted in the LVOT, and gross and microscopic explant studies are required to judge on the definitive outcome of these grafts.
authors.affiliation: European Homograft Bank, International Association, Military Hospital, rue Bruyn, B-1120, Brussels, Belgium. jasharir@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Jashari
authors.forename: B
authors.initials: B
authors.lastname: Van Hoeck
authors.forename: M
authors.initials: M
authors.lastname: Gaudino
authors.forename: W
authors.initials: W
authors.lastname: Daenen
authors.forename: T
authors.initials: T
authors.lastname: Van Geldorp
authors.forename: P
authors.initials: P
authors.lastname: Kalmar
authors.forename: Y
authors.initials: Y
authors.lastname: Goffin
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000601:surgery; D015925:Cryopreservation; D004452:Echocardiography; D005260:Female; D006085:Graft Survival; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D008297:Male; D011664:Pulmonary Valve / Q000000981:diagnostic imaging / Q000637:transplantation*; D013997:Time Factors; D014184:Transplantation, Homologous