title: Presence and extent of extrapancreatic fluid collections are indicators of severe acute pancreatitis.
abstract: BACKGROUND
  It has been suggested that early localization of both necrosis and extrapancreatic fluid collections by contrast-enhanced computed tomography (CT) can predict the outcome in severe acute pancreatitis. These two assumptions were evaluated.
  
  
  METHODS
  This study comprises 228 patients with a first attack of acute pancreatitis admitted to our clinic from 1987 to 1995 and for whom the prognostic value of a contrast-enhanced CT obtained within 72 h of admission was prospectively evaluated. These CTs were retrospectively re-evaluated for the localization of pancreatic necrosis and extrapancreatic fluid collections. The indication for dialysis and artificial ventilation, the development of pancreatic pseudocysts, the necessity for surgery (necrosectomy), and mortality were used as clinical parameters.
  
  
  RESULTS
  There was a significant correlation between the presence of pancreatic necrosis and extrapancreatic fluid collections versus the clinical parameters. The localization of pancreatic necrosis was of no importance for the outcome of the disease, whereas the increasing amount of extrapancreatic fluid collections paralleled the severity of acute pancreatitis.
  
  
  CONCLUSIONS
  Pancreatic necrosis and extrapancreatic fluid collections are indicators for severe acute pancreatitis. Whereas the localization of pancreatic necrosis is not important for the outcome of the disease, the extent of extrapancreatic fluid collections is significantly correlated with a severe course.
authors.affiliation: Department of Internal Medicine, Municipal Clinic, Lüneburg, Germany.
authors.forename: P G
authors.initials: PG
authors.lastname: Lankisch
authors.forename: K
authors.initials: K
authors.lastname: Struckmann
authors.forename: D
authors.initials: D
authors.lastname: Lehnick
mesh_terms: D000005:Abdomen; D000208:Acute Disease; D000328:Adult; D001826:Body Fluids / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D006801:Humans; D008875:Middle Aged; D008954:Models, Biological; D009336:Necrosis; D010179:Pancreas / Q000000981:diagnostic imaging / Q000473:pathology; D010195:Pancreatitis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D011860:Radiography, Abdominal; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed