In vitro inhibition properties of a new group of thiobenzanilides in relation to yeasts.
The antifungal potency of a series of 2,4-dihydroxythiobenzanilides was tested. MIC assessments were used for the estimation of potential activity in vitro against Candida, Cryptococcus, Geotrichum and Trichosporon species. The strongest fungistatic activity was observed for dichloro derivatives (MIC 7.82-31.21 microg/ml). The action of these compounds depends on lipophilicity, determined by the substitution of N-aryl moiety and the electron properties of molecules. The lipophilicity, expressed by R(Mw) values, was determined in the reversed-phase system. The changes in the nature of the thioamide bond were interpreted on the basis of UV and 1H NMR spectra.
Matysiak
J
J
University of Agriculture, Department of Chemistry, Akademicka 15, 20-950 Lublin, Poland.
Niewiadomy
A
A
Macik-Niewiadomy
G
G
D000813:Anilides / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002855:Chromatography, Thin Layer; D003455:Cryptococcus neoformans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D013854:Thioamides / Q000494:pharmacology*; D014250:Trichosporon / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects*
D000813:Anilides; D000935:Antifungal Agents; D013854:Thioamides