title: Synthesis and biological activities of NB-506 analogues modified at the glucose group.
abstract: A new indolocarbazole compound, NB-506 (1), modified at the glucose group yielded a beta-D-glucopyranoside, J-107,088 (2), which showed potent anticancer activity. A beta-D-ribofuranoside, J-109,534 (3), was found to be 6 times more potent than J-107,088 at inhibiting topoisomerase I.
authors.affiliation: Banyu Tsukuba Research Institute, Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ohkubo
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Honma
authors.forename: T
authors.initials: T
authors.lastname: Yoshinari
authors.forename: H
authors.initials: H
authors.lastname: Arakawa
authors.forename: H
authors.initials: H
authors.lastname: Suda
authors.forename: H
authors.initials: H
authors.lastname: Morishima
authors.forename: S
authors.initials: S
authors.lastname: Nishimura
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D005947:Glucose / Q000737:chemistry; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007211:Indoles; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013237:Stereoisomerism; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D004791:Enzyme Inhibitors; D005960:Glucosides; D007211:Indoles; C092476:NB 506; D059004:Topoisomerase I Inhibitors; C121395:edotecarin; D005947:Glucose