Cytotoxicity and antileishmanial activity of Annona muricata pericarp.
Hexane, ethyl acetate and methanol extracts of Annona muricata pericarp were tested in vitro against Leishmania braziliensis and L. panamensis promastigotes, and against cell line U-937. The ethyl acetate extract was more active than the other extracts and even of Glucantime used as reference substance. Its fractionation led to the isolation of three acetogenins--annonacin, annonacin A and annomuricin A.
Jaramillo
M C
MC
Facultad de Química Farmacéutica, Universidad de Antioquia, A. A. 1226 Medellín, Colombia.
Arango
G J
GJ
González
M C
MC
Robledo
S M
SM
Velez
I D
ID
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line / Q000187:drug effects; D005663:Furans / Q000737:chemistry; D006801:Humans; D007783:Lactones / Q000737:chemistry; D007891:Leishmania / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal
D000981:Antiprotozoal Agents; D005663:Furans; D007783:Lactones; D010936:Plant Extracts; C095611:annomuricin A; C053442:annonacin; D015107:4-Butyrolactone