[Active constituents reducing side-effects of prednisone acetate in leaves of Panax ginseng C.A.Mey].
The rise of total lipid, triglyceride and total cholesterol, and the drop of cortisol in serum induced by PA can be significantly inhibited by total ginsenosides in the leaves of Panax ginseng [GSL, 60 mg/(kg.d)]. From GSL ten compounds have been isolated and identified as ginsenoside-Rb2, -Rc, -Rd, -Re, -Rg1 -F3, F2, -Rg2, 20(R)-Rg2 and -Rh1, respectively. Pharmacological study has proved ginsenoside-Re to be the chief active constituent of GSL.
Dou
D
D
Department of Phytochemistry, Shenyang Pharmaceutical University.
Wen
Y
Y
Pei
Y
Y
Chen
Y
Y
Ma
Z
Z
D000818:Animals; D002784:Cholesterol / Q000097:blood; D036145:Ginsenosides; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D005894:Panax / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D011241:Prednisone / Q000009:adverse effects*; D011817:Rabbits; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D036145:Ginsenosides; D000960:Hypolipidemic Agents; D008055:Lipids; D012503:Saponins; D014280:Triglycerides; C049864:ginsenoside Re; D002784:Cholesterol; D011241:Prednisone