In situ interleukin-6 transcription in embryonic nonmuscle myosin heavy chain expressing immature mesenchyme cells of cardiac myxoma.
Cardiac myxomas are benign tumors which sometimes secrete interleukin-6 (IL-6), however, the pathogenesis and the IL-6 secreting cells are not clear. There are vascular myosin heavy chain isoforms; SM2 expression is specific to mature smooth muscle cells, while SMemb is a nonmuscle-type isoform which is expressed in immature mesenchyme cells. We hypothesized that immature mesenchyme cells play pivotal roles in the secretion of IL-6; we studied these expression in resected samples of myxoma. SMemb expression was increased but SM2 expression was not in the channels of myxoma. Increased IL-6 transcription was observed in the SMemb expressing cells in the channel. Therefore, mesenchyme cells with immature phenotype in the channel play pivotal roles of inflammation and pathogenesis of cardiac myxoma.
Suzuki
J
J
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Takayama
K
K
Mitsui
F
F
Kono
T
T
Yazaki
Y
Y
Takei
M
M
Amano
J
J
Isobe
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006325:Heart Atria / Q000378:metabolism* / Q000473:pathology; D006338:Heart Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D015850:Interleukin-6 / Q000096:biosynthesis / Q000235:genetics*; D008297:Male; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D008875:Middle Aged; D018995:Myosin Heavy Chains / Q000096:biosynthesis / Q000235:genetics*; D009232:Myxoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000096:biosynthesis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic
D004273:DNA, Neoplasm; D015850:Interleukin-6; D020033:Protein Isoforms; D012333:RNA, Messenger; D002097:C-Reactive Protein; D018995:Myosin Heavy Chains