title: Premorbid IQ in patients with functional psychosis and their first-degree relatives.
abstract: Numerous studies have found deficits in premorbid IQ in schizophrenic patients, but it is not clear whether this deficit is shared by (a) patients with other functional psychoses, and (b) relatives of these patients. Ninety-one schizophrenic patients, 66 affective psychotic patients (29 schizoaffective and 37 manic or depressed), and 50 normal control subjects were administered the National Adult Reading Test (NART) which provides an estimate of premorbid IQ. The NART was also completed by 85 first-degree relatives of schizophrenic patients and by 65 first-degree relatives of affective psychotic patients. After adjustments were made for sex, social class, ethnicity and years of education, schizophrenic patients had significantly lower premorbid IQ than their relatives, the affective psychotic patients and controls. Manic and depressed patients had significantly lower NART scores than their first-degree relatives, but schizoaffective patients did not, and neither group differed significantly from controls. There was no significant difference in premorbid IQ between patients who had experienced obstetric complications (OC+) and those who had not (OC-). Both OC+ and OC- schizophrenic patients differed significantly from their relatives, but the disparity was greatest between OC+ patients and their relatives. Relatives of OC+ schizophrenic patients had significantly higher IQ than relatives of OC- schizophrenic patients.
authors.affiliation: Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK.
authors.forename: C
authors.initials: C
authors.lastname: Gilvarry
authors.forename: N
authors.initials: N
authors.lastname: Takei
authors.forename: A
authors.initials: A
authors.lastname: Russell
authors.forename: T
authors.initials: T
authors.lastname: Rushe
authors.forename: D
authors.initials: D
authors.lastname: Hemsley
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007360:Intelligence / Q000235:genetics*; D007361:Intelligence Tests / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics*