New 1,4-anthracene-9,10-dione derivatives as potential anticancer agents.
The amino-substituted anthracene-9,10-dione (9,10-anthraquinone) derivatives represent one of the most important classes of potential anticancer agents. To better understand the basic rules governing DNA sequence specificity, we have recently synthesized a new class of D- and L-aminoacyl-anthraquinone derivatives. We have tested these new compounds as cytotoxic agents, and we have correlated their activity with the configuration of the chiral aminoacyl moiety. Molecular modeling studies have been performed to compare the test drugs in terms of steric overlapping.
Zagotto
G
G
Dipartimento di Scienze Farmaceutiche, Università di Padova, Italy. giuseppe@purple.dsfarm.unipd.it
Supino
R
R
Favini
E
E
Moro
S
S
Palumbo
M
M
D000880:Anthraquinones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000880:Anthraquinones; D000970:Antineoplastic Agents