Comparison of acetaminophen, ibuprofen, and nabumetone therapy in rats with pulpal pathosis.
The purpose of this study was to determine if daily treatment with acetaminophen, ibuprofen, or nabumetone would alter prostaglandin E2 (PGE2)/leukotriene B4 (LTB4) synthesis in exposed, infected dental pulp and periradicular tissue in rats. Dental pulp of the bilateral first and second mandibular molars were exposed for 15 or 24 days. Rats were divided into four groups. A daily pharmacological oral dose of one of the medications or the suspending solution alone was administered to the designated group. Eicosanoids were extracted from pulpal and periradicular tissues and assayed. PGE2 was significantly elevated in pulp-exposed, nontreated rats and was significantly reduced in the ibuprofen- and nabumetone-treated groups. LTB4 was significantly increased in all pulp-exposed groups at 15 days when compared with control nonexposed groups. Results showed that only ibuprofen reduced LTB4 in the exposed dental pulp at 24 days, although it did not do so at 15 days. Repetitive treatment with acetaminophen did not suppress PGE2/LTB4 in pulp-exposed molars.
Hutchins
M
M
Department of Basic Sciences, University of Texas-Houston 77030, USA.
Housholder
G
G
Suchina
J
J
Rittman
B
B
Rittman
G
G
Montgomery
E
E
D000082:Acetaminophen / Q000494:pharmacology* / Q000627:therapeutic use; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D002074:Butanones / Q000494:pharmacology / Q000627:therapeutic use; D003789:Dental Pulp Exposure / Q000188:drug therapy* / Q000378:metabolism*; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008297:Male; D000077430:Nabumetone; D011448:Prostaglandin Antagonists / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D020024:Leukotriene Antagonists; D011448:Prostaglandin Antagonists; D007975:Leukotriene B4; D000082:Acetaminophen; D015232:Dinoprostone; D000077430:Nabumetone; D007052:Ibuprofen