title: Antifungal activity of magnolol and honokiol.
abstract: Two neolignan compounds, magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl, 1) and honokiol (5,5'-diallyl-2,4'-dihydroxybiphenyl, 2), were isolated from the stem bark of Magnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound 1 and 2 showed significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 microg/ml. Therefore, compound 1 and 2 could be used as lead compounds for the development of novel antifungal agents.
authors.affiliation: R & D Center, Kolon Pharmaceutical Inc., Taejon, Korea.
authors.forename: K H
authors.initials: KH
authors.lastname: Bang
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
authors.forename: B S
authors.initials: BS
authors.lastname: Min
authors.forename: M K
authors.initials: MK
authors.lastname: Na
authors.forename: Y H
authors.initials: YH
authors.lastname: Rhee
authors.forename: J P
authors.initials: JP
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Bae
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D006801:Humans; D017705:Lignans; D008826:Microbial Sensitivity Tests; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000935:Antifungal Agents; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols