Effects of portal-systemic shunt following 90% partial hepatectomy in rats.
We studied the effects of portal-systemic shunt after massive hepatectomy. Male Wistar rats were divided into two groups: one group underwent laparotomy alone (C group) and in the other group a portal-systemic shunt was placed through laparotomy (S group). After 90% hepatectomy was performed, 3-day and 1-week survival rates and histopathology were examined, and hepatic hemodynamics during the early stage after hepatectomy were measured using dye-containing microspheres. The 3-day survival rate in the S group was significantly higher, and the 1-week survival rate was slightly higher, than those in C group. Sinusoidal dilation 7 days after hepatectomy in the S group was significantly milder than that in the C group. Fatty degeneration of hepatocytes in the S group was significantly milder than that in the C group. With respect to hepatic hemodynamics during the early stage after hepatectomy, the rate of shunt (26.3%) in the S group was significantly higher than that (9.5%) in the C group. Portal pressure, total hepatic blood flow, and total hepatic blood flow per gram of liver in the S group were significantly lower than those in the C group. These results suggest that approximately 26% shunt after 90% hepatectomy in rats increases the early survival rate and improves histological changes in surviving rats 7 days after resection.
Fukuchi
T
T
First Department of Surgery, Gifu University School of Medicine, 40 tsukasa-cho, Gifu, 500, Japan.
Hirose
H
H
Onitsuka
A
A
Hayashi
M
M
Senga
S
S
Imai
N
N
Shibata
M
M
Yamauchi
K
K
Futamura
N
N
Sumi
Y
Y
D000818:Animals; D006439:Hemodynamics; D006498:Hepatectomy / Q000379:methods* / Q000401:mortality; D008099:Liver / Q000473:pathology; D008102:Liver Circulation; D008115:Liver Regeneration; D008297:Male; D009929:Organ Size; D011170:Portasystemic Shunt, Surgical; D011184:Postoperative Period; D051381:Rats; D017208:Rats, Wistar; D012086:Reoperation