title: [Blood transfusion and bacterial risk].
abstract: Initial hemovigilance data confirm the incidence and severity of transfusion reactions due to the bacterial contamination of blood components (TRBCs). With 18 deaths reported through the French hemovigilance network over the past five years, bacterial risks represent one of the major immediate complications of BC transfusion. BC contamination may lead to more or less severe TRBCs, depending on their origin: bacteria growth, the BC itself or unknown origin. Although the rate of donated blood or BC contamination is known (0.5% and 0.05%, respectively), it is still difficult to assess the actual incidence of TRBCs, as it is difficult to identify and relate them to transfusion. Likewise, a better knowledge of bacteria, symptoms, and outcome is required to improve prevention methods. Better prevention can reduce BC contamination and proliferation of bacteria at each stage of blood transfusion. Methods of detecting BC contamination are still under investigation. Through continuous education of hemovigilance participants in identifying and dealing with TRBCs, as well as drawing up procedures to perform inquiries and specific bacterial analyses, case reporting can be further improved, in order to achieve more efficient prevention.
authors.affiliation: Etablissement de transfusion sanguine de Franche-Comté, BP 1937, Besançon, France.
authors.forename: P
authors.initials: P
authors.lastname: Morel
authors.forename: M F
authors.initials: MF
authors.lastname: Leconte des Floris
authors.forename: L
authors.initials: L
authors.lastname: Bardiaux
authors.forename: F
authors.initials: F
authors.lastname: Pouthier
authors.forename: P
authors.initials: P
authors.lastname: Hervé
mesh_terms: D016470:Bacteremia / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control / Q000635:transmission; D016913:Blood Component Transfusion / Q000009:adverse effects; D001782:Blood Donors; D001793:Blood Preservation; D001800:Blood Specimen Collection; D003937:Diagnosis, Differential; D004203:Disinfection; D004866:Equipment Contamination; D006801:Humans; D012306:Risk; D012867:Skin / Q000382:microbiology; D065227:Transfusion Reaction