title: Uterine contractility is necessary for the clearance of intrauterine fluid but not bacteria after bacterial infusion in the mare.
abstract: Bacteria were infused into the uteri of 5 estrous mares resistant to persistent mating-induced endometritis, first during a control cycle, and then during treatment with clenbuterol, a beta 2 agonist. Uterine cellular response was evaluated 48 h later by transrectal ultrasonography, followed by uterine lavage. During clenbuterol treatment all mares accumulated intrauterine fluid, whereas in the control cycle none of the mares retained fluid. There was no significant difference between the 2 cycles in the cloudiness of the lavage fluid, number of cells per milliliter, percentage of neutrophils and frequency of bacterial growth from the recovered fluid. We conclude that uterine contractility is important in the clearance of uterine fluid, but not necessarily for the elimination of bacteria, thus supporting the published evidence that impaired uterine contractility contributes to the pathogenesis of persistent mating-induced endometritis.
authors.affiliation: University of Edinburgh, Department of Veterinary Clinical Studies, Easter Bush, Midlothian, UK.
authors.forename: E
authors.initials: E
authors.lastname: Nikolakopoulos
authors.forename: E D
authors.initials: ED
authors.lastname: Watson
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification*; D002976:Clenbuterol / Q000494:pharmacology; D004716:Endometritis / Q000209:etiology / Q000662:veterinary; D004971:Estrus; D005260:Female; D006734:Horse Diseases / Q000209:etiology; D006736:Horses; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D014599:Uterus / Q000187:drug effects / Q000382:microbiology* / Q000502:physiology*
chemical_list: D002976:Clenbuterol