title: Splenic smooth-muscle tumors in children with acquired immunodeficiency syndrome: report of two cases of this unusual location with evidence of an association with Epstein-Barr virus.
abstract: Smooth-muscle neoplasms are rarely located in the spleen. They have been previously reported in five cases of children with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS). Two cases of children with HIV infection/AIDS with autopsy and surgical pathology evidence of multiple smooth-muscle neoplasms with splenic involvement are presented. DNA was extracted from histology slides in both cases for analysis for Epstein Barr (EB) virus. In both cases, the presence of EB virus was confirmed. This paper documents two additional cases of the unusual phenomenon of splenic involvement by smooth-muscle neoplasms in the setting of AIDS in childhood and further supports the role of EB virus in the development of these neoplasms.
authors.affiliation: Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, Newark 07103, USA.
authors.forename: V
authors.initials: V
authors.lastname: Barbashina
authors.forename: D S
authors.initials: DS
authors.lastname: Heller
authors.forename: M
authors.initials: M
authors.lastname: Hameed
authors.forename: E
authors.initials: E
authors.lastname: Albanese
authors.forename: M
authors.initials: M
authors.lastname: Goldstein
authors.forename: B
authors.initials: B
authors.lastname: Dashefsky
authors.forename: A
authors.initials: A
authors.lastname: Dieudonne
authors.forename: R
authors.initials: R
authors.lastname: Chakraborty
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D017809:Fatal Outcome; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007890:Leiomyosarcoma / Q000150:complications* / Q000473:pathology / Q000821:virology; D008297:Male; D016133:Polymerase Chain Reaction; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000150:complications* / Q000473:pathology / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology / Q000821:virology
chemical_list: D017931:DNA Primers; D004273:DNA, Neoplasm; D004279:DNA, Viral