title: Influence of extracorporeal irradiation on the reintegration of autologous grafts of bone and joint. Study in a canine model.
abstract: We studied the effects of irradiation on the reintegration of autologous osteoarticular grafts over a period of 24 weeks in a canine model. In 16 foxhounds the medial femoral condyle was resected, irradiated and immediately replanted. In the control group resection and replantation were performed without irradiation. Reintegration was assessed by macroscopic analysis, histology, radiography and gait analysis. Reintegration was equal at 12 weeks, but significantly inferior in the irradiated group after 24 weeks with delayed bone remodelling. The articular cartilage showed modest degeneration. Conventional radiography and histology showed corresponding changes. Limb function was adequate but the gait was inferior in the treated group.
authors.affiliation: Department of Orthopaedic Surgery, University of Heidelberg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Sabo
authors.forename: D R
authors.initials: DR
authors.lastname: Brocai
authors.forename: M
authors.initials: M
authors.lastname: Eble
authors.forename: M
authors.initials: M
authors.lastname: Wannenmacher
authors.forename: V
authors.initials: V
authors.lastname: Ewerbeck
mesh_terms: D000818:Animals; D016723:Bone Remodeling / Q000528:radiation effects; D016025:Bone Transplantation / Q000473:pathology*; D004285:Dogs; D005269:Femur / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D008297:Male; D016348:Osseointegration / Q000528:radiation effects*; D012092:Replantation