title: Long-term peripheral treatment of immature coho salmon (Oncorhynchus kisutch) with human leptin has no clear physiologic effect.
abstract: The effects of long-term peripheral exposure to recombinant human leptin were tested in immature coho salmon under both fed and fasted conditions. We found that high circulating levels of human leptin did not alter growth, energy stores, gonad weight, pituitary content of follicle-stimulating hormone, or plasma levels of insulin-like growth factor-I, insulin, growth hormone, or thyroxine.
authors.affiliation: School of Fisheries, University of Washington, Seattle, Washington, 98195, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Baker
authors.forename: D A
authors.initials: DA
authors.lastname: Larsen
authors.forename: P
authors.initials: P
authors.lastname: Swanson
authors.forename: W W
authors.initials: WW
authors.lastname: Dickhoff
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004343:Drug Implants; D004734:Energy Metabolism / Q000187:drug effects; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D006728:Hormones / Q000097:blood; D006801:Humans; D020738:Leptin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D008112:Liver Glycogen / Q000378:metabolism; D017684:Oncorhynchus kisutch / Q000502:physiology*; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay; D011994:Recombinant Proteins / Q000494:pharmacology
chemical_list: D004343:Drug Implants; D006728:Hormones; D020738:Leptin; D008112:Liver Glycogen; D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone