title: Azithromycin eruption in infectious mononucleosis: a proposed mechanism of interaction.
abstract: The penicillin family of antibiotics may induce drug eruptions when prescribed to patients with infectious mononucleosis. Very similar phenomena have also been cited with other antibiotic families. We report the first case of a cutaneous reaction in a patient with infectious mononucleosis treated with azithromycin. We propose an immune-based hypothesis to explain the transient sensitivity resulting in this secondary cutaneous eruption.
authors.affiliation: US Army Medical Department Activity, Heidelberg, Germany.
authors.forename: D J
authors.initials: DJ
authors.lastname: Schissel
authors.forename: D
authors.initials: D
authors.lastname: Singer
authors.forename: K
authors.initials: K
authors.lastname: David-Bajar
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D017963:Azithromycin / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D006919:Hydroxyzine / Q000008:administration & dosage; D007244:Infectious Mononucleosis / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology*; D008297:Male; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D014221:Triamcinolone; D006919:Hydroxyzine; D017963:Azithromycin