Resistance-modifying agents. Part 7: 2,6-disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines that inhibit nucleoside transport in the presence of alpha1-acid glycoprotein (AGP).
The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to alpha1-acid glycoprotein, is reported.
Barlow
H C
HC
Department of Chemistry, The University, Newcastle upon Tyne, UK.
Bowman
K J
KJ
Curtin
N J
NJ
Calvert
A H
AH
Golding
B T
BT
Huang
B
B
Loughlin
P J
PJ
Newell
D R
DR
Smith
P G
PG
Griffin
R J
RJ
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D009705:Nucleosides / Q000378:metabolism*; D009961:Orosomucoid / Q000378:metabolism*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D009705:Nucleosides; D009961:Orosomucoid; D011743:Pyrimidines