[Expression of urokinase and its receptor correlate with proliferation of smooth muscle cell in injured arteries].
Using the immunohistochemistry and a standard reverse transcriptase-polymerase chain reaction assay optimized to estimate the mRNA levels, we observed a 2-fold increased uPA expression by the SMCs in injured vessels as compared with uninjured vessels. The uPA elevation occurred within 6 hours from the injury and persisted for 96 hours after the injury. The uPAR expression was also elevated after an injury although it occurred slower and more gradually. The data obtained suggest that the uPA is capable of contributing to both the SMC migration, replication and accumulation in the neointima early after balloon catheter injury of the carotid artery in rats.
Plekhanova
O S
OS
Cardiology Research Centre, 121552 3rd Cherepkovskaya St. 15a, Moscow, Russia.
Kalinina
N I
NI
Volynskaia
E A
EA
Parfenova
E V
EV
D000800:Angioplasty, Balloon; D000818:Animals; D002455:Cell Division; D002465:Cell Movement; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000201:enzymology* / Q000473:pathology*; D051381:Rats; D011921:Rats, Inbred WKY; D011956:Receptors, Cell Surface / Q000378:metabolism*; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
C524900:Plaur protein, rat; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator