title: Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis.
abstract: T cell responses to myelin basic protein (MBP) are potentially involved in the pathogenesis of multiple sclerosis (MS). In this study, we demonstrated that subcutaneous inoculations with irradiated autologous MBP-reactive T cell clones (T cell vaccination) elicited CD8+ anti-idiotypic T cell responses and CD4+ Th2 cell responses in patients with MS. Both regulatory cell types induced by T cell vaccination contributed to the inhibition of MBP-reactive T cells while they differed in the recognition pattern and functional properties. We describe for the first time that the Th2 regulatory cells reacted with activated but not resting T cells in the context of MHC class II molecules and inhibited the proliferation of MBP-reactive T cells through the secretion of IL-4 and IL-10. The T-T cell interaction mediated by Th2 regulatory cells was independent of the antigen specificity of activated T cells. The findings have important implications for our understanding of the regulatory mechanism induced by T cell vaccination.
authors.affiliation: Multiple Sclerosis Research Laboratory, Department of Neurology, Baylor College of Medicine, Houston 77030, USA. jzang@bcm.tmc.edu
authors.forename: Y C
authors.initials: YC
authors.lastname: Zang
authors.forename: J
authors.initials: J
authors.lastname: Hong
authors.forename: M V
authors.initials: MV
authors.lastname: Tejada-Simon
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: V M
authors.initials: VM
authors.lastname: Rivera
authors.forename: J M
authors.initials: JM
authors.lastname: Killian
authors.forename: J Z
authors.initials: JZ
authors.lastname: Zhang
mesh_terms: D015551:Autoimmunity; D002460:Cell Line; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy*; D004676:Myelin Basic Protein / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014611:Vaccination
chemical_list: D016207:Cytokines; D004676:Myelin Basic Protein