title: [A multicenter study of the antimicrobial effect of Macmiror and Macmiror Complex in the treatment of vaginal infections].
abstract: The aim of the present multicentre study was to examine the therapeutic possibilities of the wide-spectrum medicament MACMIROR & MACMIROR COMPLEX for the treatment of the vaginal infections.
  
  
  METHODS
  The study included 159 nonpregnant women among 15 and 54 years (middle age 35.6) with different by kind and intensity colpitis complaints. The following microbiological characteristic was established: in 26 cases Gardnerella vaginalis, in 46 Candida spp., and in the rest 87-mixed aerobic bacterial flora, with a combination of Gardnerella, yeast and Trichomonas. The treatment of the patients was done in combined scheme: peroral and vaginal administration, simultaneously with local treatment of the partner. The control examination was performed bistagely: on 7-10 day and on 30-40 day.
  
  
  RESULTS
  The good clinical and microbiological influence of the treated patients was established, for the first control examination the effect was found in 88.1% and 86.8% and for the second--respectively in 81.1% and 82.4%.
  
  
  CONCLUSIONS
  The received results give us a cause to approve, that the combination "Nifuratel and Nystatin" (Macmiror & Macmimor complex) has the good possibilities to influence the mixed forms of vaginal infection.
authors.forename: I
authors.initials: I
authors.lastname: Karag'ozov
authors.forename: E
authors.initials: E
authors.lastname: Shopova
authors.forename: K
authors.initials: K
authors.lastname: Poriazov
authors.forename: I
authors.initials: I
authors.lastname: Abaliev
authors.forename: I
authors.initials: I
authors.lastname: Kozovski
authors.forename: R
authors.initials: R
authors.lastname: Ianeva
authors.forename: S
authors.initials: S
authors.lastname: Drenska
authors.forename: P
authors.initials: P
authors.lastname: Vasileva
authors.forename: S
authors.initials: S
authors.lastname: Bozhinova
authors.forename: I
authors.initials: I
authors.lastname: Popov
authors.forename: S
authors.initials: S
authors.lastname: Stoĭkov
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D000994:Antitrichomonal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006194:Gardnerella vaginalis; D006801:Humans; D008875:Middle Aged; D009545:Nifuratel / Q000627:therapeutic use*; D009761:Nystatin / Q000627:therapeutic use*; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000188:drug therapy*; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000994:Antitrichomonal Agents; D004338:Drug Combinations; D009761:Nystatin; D009545:Nifuratel