title: [Coinfection with HIV and HTLV-I infection and survival in AIDS stage. French Guiana Study. GECVIG (Clinical HIV Study Group in Guiana)].
abstract: OBJECTIVE
  The purpose of this study was to investigate the effect of HTLVI infection on survival in AIDS patients in French Guiana.
  
  
  METHODS
  A cohort of 151 adult patients with AIDS were followed from January 1992 through June 1996. Kaplan-Meier survival curves were established. Using the Cox model, multivariate analysis was performed to examine different factors affecting survival.
  
  
  RESULTS
  The incidence of HTLVI infection in this cohort was 11.9% and 57.6% of the patients died during the study period. Multivariate analysis disclosed that older age at diagnosis of AIDS (over 45 years) and low CD4 count (< 100/mm3) were predictors of poor survival. HIV-HTLVI co-infection was strongly correlated with reduced survival (p = 0.02; RR = 2.2; CI = 1.1-4.5).
  
  
  CONCLUSIONS
  In our region, all patients with HIV infection should be screened for HTLVI infection. In case of co-infection, early care should included adapted antiretroviral regimens.
authors.affiliation: Centre d'Information et de Soins de l'Immunodéficience humaine, CHG de Cayenne. sobeskym@nplus.gf
authors.forename: M
authors.initials: M
authors.lastname: Sobesky
authors.forename: P
authors.initials: P
authors.lastname: Couppie
authors.forename: R
authors.initials: R
authors.lastname: Pradinaud
authors.forename: M C
authors.initials: MC
authors.lastname: Godard
authors.forename: F
authors.initials: F
authors.lastname: Alvarez
authors.forename: B
authors.initials: B
authors.lastname: Benoît
authors.forename: B
authors.initials: B
authors.lastname: Carme
authors.forename: P
authors.initials: P
authors.lastname: Lebeux
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality; D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005616:French Guiana / Q000453:epidemiology; D015490:HTLV-I Infections / Q000150:complications* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate