Alpha-tocopherol derivatives and wound healing in an experimental model of filtering surgery.
OBJECTIVE
To describe the effect of alpha-tocopherol derivatives (acetate and acid-succinate) on the histopathological characteristics of the surgical fistula in an experimental model of filtering surgery.


METHODS
Thirty pigmented rabbits were divided into 3 groups. Twenty-four hours before surgery the animals were injected subconjunctivally with 0.5 mL of solution that depended on the group of treatment: Group 1 (n = 10) 0.75% ethanol in balanced salt solution (BSS); Group 2 (n = 10) 100 microg alph-tocopherol-acetate in 0.75% ethanol in BSS; Group 3 (n = 10) 100 microg alpha-tocopheryl-acid-succinate in 0.75% ethanol in BSS. Histological findings were evaluated 30 days after surgery.


RESULTS
The groups treated with alpha-tocopherol derivatives showed a higher percentage of persistence of the fistula and better intraocular pressure (IOP) control.


CONCLUSIONS
Alpha-tocopherol derivatives showed antiproliferative properties in this experimental model of filtering surgery.
Larrosa
J M
JM
Department of Ophthalmology, Miguel Servet Hospital, Zaragoza, Spain. jlarrosa@encomix.es
Polo
V
V
Ramirez
T
T
Pinilla
I
I
Pablo
L E
LE
Honrubia
F M
FM
D000818:Animals; D004195:Disease Models, Animal; D018463:Filtering Surgery; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000601:surgery; D011817:Rabbits; D012590:Sclera / Q000601:surgery; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols