14-3-3 proteins and growth control.
The 14-3-3 proteins constitute a family that is highly conserved in a wide range of organisms, including higher eukaryotes, invertebrates and plants. Variants of 14-3-3 proteins assembled in homo- and heterodimers were found to interact with diverse cellular proteins. Until recently, the biological role of 14-3-3 members was still poorly understood. However, the results of an increasing number of studies on their structure and function are converging to define 14-3-3 proteins as a novel type of adaptor that modulates interactions between components involved in signal transduction pathway and in cell cycle control.
Baldin
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Laboratoire de Biologie Cellulaire et Moléculaire du Contrôle de la Prolifération Université Paul Sabatier-CNRS, Toulouse, France.
D048948:14-3-3 Proteins; D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D014446:Tyrosine 3-Monooxygenase
D048948:14-3-3 Proteins; D011506:Proteins; D014446:Tyrosine 3-Monooxygenase