title: Mechanisms of angiogenesis and arteriogenesis.
abstract: Endothelial and smooth muscle cells interact with each other to form new blood vessels. In this review, the cellular and molecular mechanisms underlying the formation of endothelium-lined channels (angiogenesis) and their maturation via recruitment of smooth muscle cells (arteriogenesis) during physiological and pathological conditions are summarized, alongside with possible therapeutic applications.
authors.affiliation: The Center for Transgene Technology and Gene Therapy Flanders Interuniversity Institute for Biotechnology KU Leuven, Leuven, B-3000, Belgium. peter.carmeliet@med.kuleuven.ac.be
authors.forename: P
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000818:Animals; D001160:Arterioles / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000254:growth & development; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology