title: Salmonella paratyphi A is more genetically homogeneous than Salmonella typhi, as indicated by pulsed-field gel electrophoresis.
abstract: We analyzed 18 Salmonella Paratyphi A and 12 Salmonella Typhi isolates from domestic and imported cases in Aichi, Japan, using pulsed-field gel electrophoresis. Paratyphoid fever cases have increased and outbreaks of Salmonella Paratyphi A occasionally occur in Japan, but S. Paratyphi A has not been extensively analyzed. Our study suggests significant genetic homogeneity among Salmonella Paratyphi A belonging to different phage types, which is in contrast to the genetic heterogeneity of Salmonella Typhi. These results suggest that a limited number of clones are responsible for paratyphoid fever.
authors.affiliation: Department of Microbiology, Aichi Prefectural Institute of Public Health, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Miwa
authors.forename: R
authors.initials: R
authors.lastname: Hiramatsu
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: M
authors.initials: M
authors.lastname: Saito
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D001434:Bacteriophage Typing; D016521:Electrophoresis, Gel, Pulsed-Field; D018740:Genetic Heterogeneity; D012482:Salmonella paratyphi A / Q000235:genetics*; D012485:Salmonella typhi / Q000235:genetics*