Analysis of difference in vivo effects of TCDD between c-src +/+ mice, c-src deficient, -/+ and -/- B6, 129-Src(tm 1 sor) mice and their wild-type littermates.
Toxicities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were tested on two strains of c-src deficient B6, 129-Src(tm 1 sor) mice, c-src -/+ and c-src -/- and their matched wild-type littermates c-src +/+ mice along with another c-src +/+ mice, from the same genetic lineage, B6, 129-Fos(tm 1 Pa) mice. The most conspicuous effect of c-src deficiency on the toxicity of TCDD appears to be the reduced hepatotoxicity. TCDD-treated c-src deficient mice show only modest degrees of hepatomegaly and triglycerides accumulation as compared to treated wild-type mice.
Dunlap
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Department of Environmental Toxicology and the Center for Environmental Health Sciences, University of California, Davis 956165, USA.
Matsumura
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D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D006529:Hepatomegaly; D008107:Liver Diseases / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology* / Q000633:toxicity; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D014280:Triglycerides / Q000097:blood
D000072317:Polychlorinated Dibenzodioxins; D014280:Triglycerides; D016392:Proto-Oncogene Proteins pp60(c-src)