title: Whole brain quantitative CBF and CBV measurements using MRI bolus tracking: comparison of methodologies.
abstract: Three different deconvolution techniques for quantifying cerebral blood flow (CBF) from whole brain T*(2)-weighted bolus tracking images were implemented (parametric Fourier transform P-FT, parametric single value decomposition P-SVD and nonparametric single value decomposition NP-SVD). The techniques were tested on 206 regions from 38 hyperacute stroke patients. In the P-FT and P-SVD techniques, the tissue and arterial concentration time curves were fit to a gamma variate function and the resulting CBF values correlated very well (CBF(P-FT) = 1.02 x CBF(P-SVD), r(2) = 0.96). The NP-SVD CBF values (i.e., original unfitted curves were used) correlated well with the P-FT CBF values only when a sufficient number of time series volumes were acquired to minimize tracer time curve truncation (CBF(P-FT) x 0.92 x CBF(NP-SVD), r(2) = 0.88). The correlation between the fitted CBV and the unfitted CBV values was also maximized in regions with minimal tracer time curve truncation (CBV(fit) = 1.00 x CBV(unfit), r(2) = 0.89). When a sufficient number of time series volumes could not be acquired (due to scanner limitations) to avoid tracer time curve truncation, the P-FT and P-SVD techniques gave more reliable estimates of CBF than the NP-SVD technique.
authors.affiliation: Department of Radiology and Medical Imaging, Université catholique de Louvain, St. Luc University Hospital, Brussels, Belgium. Smith@topo.ucl.ac.be
authors.forename: A M
authors.initials: AM
authors.lastname: Smith
authors.forename: C B
authors.initials: CB
authors.lastname: Grandin
authors.forename: T
authors.initials: T
authors.lastname: Duprez
authors.forename: F
authors.initials: F
authors.lastname: Mataigne
authors.forename: G
authors.initials: G
authors.lastname: Cosnard
mesh_terms: D000208:Acute Disease; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000008:administration & dosage*; D017352:Echo-Planar Imaging; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA