title: Fluvoxamine pharmacotherapy of anxiety disorders in later life: preliminary open-trial data.
abstract: The authors present data from an open trial of fluvoxamine (median daily dosage: 200 mg) in the treatment of generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder in 19 older outpatients (mean age = 66.8). Of the 12 subjects completing the 21-week trial, 8 achieved a good response (50% reduction in symptom measures) and 7 were rated as much or very much improved. Fluvoxamine pharmacotherapy also had a significant effect in reducing comorbid depressive symptoms and in increasing levels of functioning. These data support the effectiveness of fluvoxamine in older subjects with anxiety disorders (particularly generalized anxiety disorder) and warrant further double-blind, placebo-controlled evaluation.
authors.affiliation: The Intervention Research Center for Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, Pennsylvania, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Wylie
authors.forename: M D
authors.initials: MD
authors.lastname: Miller
authors.forename: M K
authors.initials: MK
authors.lastname: Shear
authors.forename: J T
authors.initials: JT
authors.lastname: Little
authors.forename: B H
authors.initials: BH
authors.lastname: Mulsant
authors.forename: B G
authors.initials: BG
authors.lastname: Pollock
authors.forename: C F
authors.initials: CF
authors.lastname: Reynolds
mesh_terms: D000368:Aged; D000553:Ambulatory Care; D001008:Anxiety Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D015897:Comorbidity; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D016666:Fluvoxamine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D016666:Fluvoxamine