Locus control regions and epigenetic chromatin modifiers.
Locus control regions are defined as gene regulatory sequences that enable chromosomal position-independent gene expression in transgenic mice. Recent studies have shown the ability of such regions to overcome the highly repressive effect of heterochromatin and have identified both trans-acting and cis-acting factors that participate in gene silencing and activation mechanisms.
Festenstein
R
R
Department of Medicine, Gene Control Mechanisms and Disease, Imperial College School of Medicine, Medical Research Council, Clinical Sciences Centre, Hammersmith Hospital, London, W12 ONN. r-festen@nimr.mrc.ac.uk
Kioussis
D
D
D000818:Animals; D002843:Chromatin / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D019901:Locus Control Region / Q000235:genetics*
D002843:Chromatin