Arylamine N-acetyltransferase 1 (NAT1) genotypes in a Lebanese population.
The frequency distributions of human N-acetyltransferase 1 (NAT1*) alleles in various ethnic groups are largely unknown. This lack of information is in contrast to the many studies of ethnic differences in NAT2* alleles and phenotypes. Increasing interest in NAT1 due to its potential roles in carcinogen metabolism and cancer risk makes it desirable to know the distribution of NAT1* alleles in various populations. Using a polymerase chain reaction-restriction fragment length polymorphism genotyping assay, the frequency of NAT1* alleles in a Lebanese population was determined. Of 84 NAT1* alleles assayed, 56% were NAT1*4. Alleles NAT1*3, *10, and *14 were found at frequencies of 0.036, 0.107, and 0.238, respectively. Five additional alleles (6%) differed from previously reported alleles. Nearly 50% of the population were heterozygous for a NAT1*14 allele. The unusually high frequency of NAT1*14 alleles in Lebanese may be useful for epidemiological studies of the effects of the NAT1 polymorphism in this population.
Dhaini
H R
HR
Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, USA.
Levy
G N
GN
D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics*; D000483:Alleles; D001191:Arylamine N-Acetyltransferase; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005820:Genetic Testing; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007527:Isoenzymes; D007861:Lebanon / Q000208:ethnology; D008824:Michigan; D009154:Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D007527:Isoenzymes; D000123:Acetyltransferases; D001191:Arylamine N-Acetyltransferase; C089384:N-acetyltransferase 1