Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
We investigated three patients with cardiac angiosarcomas and two with cardiac rhabdomyosarcomas, all for mutations at exons 5, 6, 7 and 8 of the p53 gene and at exon 1 of K-ras. No point mutations were observed in the p53 gene in any of the five cases; however, at exon 1 of K-ras, three patients (60%) presented the same mutation at the first base of codon 13 (G to A transition). Interestingly, this mutation was detected in both rhabdomyosarcoma and angiosarcoma histologic sarcoma types.
Garcia
J M
JM
Department of Medical Oncology, Clinica Puerta de Hierro, Madrid, Spain.
Gonzalez
R
R
Silva
J M
JM
Dominguez
G
G
Vegazo
I S
IS
Gamallo
C
C
Provencio
M
M
España
P
P
Bonilla
F
F
D000328:Adult; D004252:DNA Mutational Analysis; D005091:Exons; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D011905:Genes, ras / Q000235:genetics*; D006338:Heart Neoplasms / Q000235:genetics*; D006394:Hemangiosarcoma / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012208:Rhabdomyosarcoma / Q000235:genetics*