title: Mixed follicular and parafollicular thyroid carcinoma.
abstract: A rare case of mixed follicular-parafollicular thyroid carcinoma which occurred in a 50-year-old man, is reported. The ultrastructural aspects of the tumor showed: a biphasic growth pattern with microfolliculi and solid areas; the coexpression of thyroglobulin and calcitonin antigens in the same follicle-like structures; the presence of neuroendocrine granules, microvilli and intracytoplasmic canaliculi bordered by microvilli. These characteristics lead us to a diagnosis of mixed follicular-parafollicular thyroid carcinoma.
authors.affiliation: II Dept. of General Surgery L. Sacco Hospital, University of Milan, Italy. kozman.vitripat@iol.it
authors.forename: P
authors.initials: P
authors.lastname: Vitri
authors.forename: A
authors.initials: A
authors.lastname: Galimberti
authors.forename: L
authors.initials: L
authors.lastname: De Pasquale
authors.forename: L
authors.initials: L
authors.lastname: Vago
authors.forename: R
authors.initials: R
authors.lastname: Boldorini
authors.forename: A
authors.initials: A
authors.lastname: Bastagli
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002116:Calcitonin / Q000032:analysis; D018276:Carcinoma, Medullary / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002455:Cell Division; D003594:Cytoplasmic Granules / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008871:Microvilli / Q000473:pathology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010166:Palliative Care; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery
chemical_list: D002116:Calcitonin; D013954:Thyroglobulin