title: Utility and quality of autologous fresh frozen plasma and autologous fibrin glue for surgical patients.
abstract: The quality of autologous fresh frozen plasma and autologous fibrin glue prepared in our hospital was evaluated. The Auto-FFP was separated from whole blood or collected using a cell separator and the Auto-FG was then prepared from the Auto-FFP. The Auto-FFP showed significantly higher levels of fibrinogen, Factor-V and Factor-VIII than commercially available FFP. The Auto-FG contained approximately 10 times the concentration of fibrinogen, Factor-VIII, Factor-XIII, von Willbrand factor and fibronectin and 1.5 times that of alpha 2-Plasminogen inhibitor compared to those of the Auto-FFP. When the Auto-FG was sprayed over diffusely bleeding sites from surgical wounds, hemostasis occurred within 5 s. These results suggest that Auto-FFP and Auto-FG may have sufficient utility and quality to reduce the use of allogeneic blood products.
authors.affiliation: Blood Transfusion Service, School of Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Komatsu
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000032:analysis; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001798:Blood Proteins / Q000032:analysis; D001804:Blood Transfusion, Autologous / Q000706:statistics & numerical data; D005069:Evaluation Studies as Topic; D005260:Female; D005337:Fibrin / Q000302:isolation & purification; D005340:Fibrinogen / Q000032:analysis; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010949:Plasma; D012189:Retrospective Studies; D013997:Time Factors; D014014:Tissue Adhesives
chemical_list: D001779:Blood Coagulation Factors; D001798:Blood Proteins; D014014:Tissue Adhesives; D005337:Fibrin; D005340:Fibrinogen