title: Clinical outcomes of post-operative locoregional radiotherapy in pre-menopausal and post-menopausal Chinese women with breast cancer.
abstract: OBJECTIVE
  Recent randomized studies from the West show that post-operative locoregional radiotherapy improves survival in lymph node (LN) positive pre-menopausal women with breast cancer but this benefit has not been established in the Chinese population. There is no published study on clinical outcomes (locoregional recurrence, survival and toxicities) of post-operative locoregional radiotherapy in Chinese women with breast cancer.
  
  
  METHODS
  We conducted a retrospective study of 399 female Chinese patients with breast cancer who had received post-mastectomy locoregional radiotherapy in our center between 1984 and 1990. The patients were stratified according to tumor size, menopausal and LN status. We analyzed the incidence and pattern of locoregional recurrence, distant recurrence, survival rates and toxicity related to radiotherapy.
  
  
  RESULTS
  Of the 399 patients 216 were pre-menopausal and 183 were post-menopausal. The mean age was 49.3 years (23-83). Distribution of tumor size and LN status of the two groups was similar. Median follow-up was 71.9 months. Locoregional recurrence occurred in 57 (14.3%) patients (pre-menopausal 24 (11.1%); post-menopausal 33 (18.3%) P=0.489). Recurrence was more common in LN positive patients (18.2%) than LN negative patients (9.2%). The pattern of locoregional recurrence was: chest wall 24, axilla LN 12, supraclavicular LN 10, chest plus LN 11. The distant recurrence rate was 39.6% for all patients and 75.4% for patients with locoregional recurrences. The overall 10-year survival rate for all patients was 54%. For LN positive patients the 10-year survival rate of pre-menopausal and post-menopausal women was 38 and 51%, respectively (P=0.207), and for LN negative patients the rate was 73 and 70%, respectively (P=0.603). Acute skin toxicity included redness (30.8%), dry desquamation (12.8%), and wet desquamation (6. 8%). Long-term toxicities included skin atrophy (0.3%), telangectasia (3.3%), pneumonitis (2.8%) and brachial plexus palsy (1.3%).
  
  
  CONCLUSIONS
  In our series Chinese patients with node-positive breast cancer have a relatively high locoregional recurrence rate in spite of mastectomy and post-operative radiotherapy. Limited use of adjuvant system chemotherapy may account, at least in part, for this finding. Clinical outcomes of post-operative radiotherapy in pre-menopausal and post-menopausal breast cancer patients are similar.
authors.affiliation: Department Of Clinical Oncology, The Chinese University Of Hong Kong, Prince Of Wales Hospital, Shatin, New Territories, Hong Kong.
authors.forename: T S
authors.initials: TS
authors.lastname: Mok
authors.forename: W H
authors.initials: WH
authors.lastname: Kwan
authors.forename: W M
authors.initials: WM
authors.lastname: Yeo
authors.forename: A T
authors.initials: AT
authors.lastname: Chan
authors.forename: E C
authors.initials: EC
authors.lastname: Chan
authors.forename: K
authors.initials: K
authors.lastname: Chak
authors.forename: D L
authors.initials: DL
authors.lastname: Chow
authors.forename: C
authors.initials: C
authors.lastname: Lo
authors.forename: T W
authors.initials: TW
authors.lastname: Leung
authors.forename: P M
authors.initials: PM
authors.lastname: Teo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D002681:China; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D017698:Postmenopause; D017697:Premenopause; D011832:Radiation Injuries; D012189:Retrospective Studies; D015996:Survival Rate