title: Focusing-in on microtubules.
abstract: A good approximation of the atomic structure of a microtubule has been derived from docking the high-resolution structure of tubulin, solved by electron crystallography, into lower resolution maps of whole microtubules. Some structural interactions with other molecules, including nucleotides, drugs, motor proteins and microtubule-associated proteins, can now be predicted.
authors.affiliation: MRC Laboratory of Molecular Biology, Cambridge, CB2 2QH, UK. laa@mrc-lmb.cam.ac.uk
authors.forename: L A
authors.initials: LA
authors.lastname: Amos
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D003599:Cytoskeleton / Q000648:ultrastructure; D004398:Dyneins / Q000737:chemistry; D020558:GTP Phosphohydrolases / Q000737:chemistry; D006801:Humans; D016547:Kinesins / Q000737:chemistry; D008870:Microtubules / Q000737:chemistry*; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D014404:Tubulin / Q000737:chemistry* / Q000378:metabolism; D016875:tau Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D020409:Molecular Motor Proteins; D014404:Tubulin; D016875:tau Proteins; D020558:GTP Phosphohydrolases; D004398:Dyneins; D016547:Kinesins