The inhibitory effects of terikalant on the contractile activity of galanin in isolated rat fundus strips.
The maximal responses (E(max)s) of isolated rat gastric fundus strips to 300 n m porcine galanin (Gal) were decreased in a concentration-dependent manner by terikalant (RP 62719). EC(50)of the agent equalled 4.39 microm (2.35-8.22). On the contrary the action of 30 n m of carbachol were not affected by the modulator in concentrations up to 30 microm. It is concluded that potassium currents may contribute to the modulation of Gal myotropic activity in the gut.
Korolkiewicz
R P
RP
Department of Pharmacology, Medical University of Gdańsk, Do Studzienki 38, Gdańsk, 80-227, Poland.
Konstański
Z
Z
Rekowski
P
P
Ruczyński
J
J
Szyk
A
A
Szczepańska
R
R
Petrusewicz
J
J
D000818:Animals; D002839:Chromans / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D019004:Galanin / Q000037:antagonists & inhibitors*; D005748:Gastric Fundus / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D002839:Chromans; D010880:Piperidines; D015221:Potassium Channels; D019004:Galanin; C063899:terikalant