title: Evaluation of melengestrol acetate and equine chorionic gonadotropin for out-of-season breeding in sheep on Prince Edward Island.
abstract: The purpose of this study was to compare the efficacy of a recommended protocol of oral melengestrol acetate (MGA) to intravaginal medroxyprogesterone acetate (MPA), with or without equine chorionic gonadotropin (eCG), for out-of-season breeding of sheep on Prince Edward Island. One hundred and twenty ewes were assigned to 1 of 4 groups in a factorial design and were treated with either an intravaginal MPA sponge or oral MGA. Ewes received either an intramuscular injection of eCG or a saline placebo at cessation of progestogen treatment. The reproductive performance was best for the MPA-eCG group, followed by the MGA-eCG, MGA-saline, and MPA-saline. Pregnancy rates of 66.7%, 43.3%, 31.0%, and 16.7%, respectively, and ratios of lambs born to ewes exposed to the ram of 1.17, 0.63, 0.52, and 0.23, respectively, were recorded for these groups. We concluded that, under the conditions of this study, the use of oral MGA resulted in fewer lambs than did the use of MPA sponges with eCG. Nonetheless, the use of MGA may be attractive to producers because it is less expensive and more convenient than the use of sponges.
authors.affiliation: Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown.
authors.forename: G P
authors.initials: GP
authors.lastname: Keefe
authors.forename: J J
authors.initials: JJ
authors.lastname: Wichtel
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000822:Animal Husbandry; D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D008552:Melengestrol Acetate / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D018873:Pregnancy Rate; D045167:Progesterone Congeners / Q000008:administration & dosage / Q000494:pharmacology*; D012098:Reproduction; D012756:Sheep / Q000502:physiology*
chemical_list: D006063:Chorionic Gonadotropin; D045167:Progesterone Congeners; D008552:Melengestrol Acetate; D017258:Medroxyprogesterone Acetate