[Modification of phospholipid composition of rat isolated heart tissue using N-stearoylethaonolamine (NSE) in a model of acute ischemia-reperfusion].
The phospholipid composition of the myocardial tissue of the isolated rat heart under acute ischemia and effect of NSE on the level of phospholipid were studied. It was shown that the level of phospholipids and PI under ischemia increased by 15% and 25% respectively, but the level of DPG decreased by 14%. The addition of NSE into the perfusion medium prevents the alterations of phospholipids and DPG levels. This suggests that NSE has some cardioprotective properties.
Artamonov
M V
MV
O.V. Palladin Institute of Biochemistry, National Academy of Sciences.
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004983:Ethanolamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D017202:Myocardial Ischemia / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism*; D013229:Stearic Acids / Q000494:pharmacology*
D002316:Cardiotonic Agents; D004983:Ethanolamines; C408368:N-stearoylethanolamine; D010743:Phospholipids; D013229:Stearic Acids