[Right atrial thrombus complicating chemotherapy by central venous catheterization in a child with Hodgkin's disease].
The atrial catheter (subcutaneous port) was used in a 5 year old boy with Hodgkin's disease for the administration of antineoplastic agents and other drugs. Catheter was flushed daily or every 2 weeks with heparin solution (5 U/ml)). The complications including infection and occlusion were not observed in this patient during observation time. Routine echocardiography performed after eight months of usage of the catheter showed right atrial thrombus. Because of the failure of 14 days fibrinolytic therapy (Actylise) surgical thrombectomy was performed. Bacteriological culture of the surgical specimen was positive for Pseudomonas aeruginosa. The post-operative period passed without complications. Follow-up echocardiography findings were normal. The probable reason of thrombus formation could be damage of the right atrium by stream of drugs or balloting ending of the catheter.
Gadomski
A
A
Katedry i Kliniki Pediatrii, Hematologii i Onkologii Akademii Medycznej w Warszawie.
Jaranowska
D
D
Ebinger
K
K
Ozimek
W
W
Brzewski
M
M
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006325:Heart Atria; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011552:Pseudomonas Infections / Q000209:etiology; D013927:Thrombosis / Q000209:etiology* / Q000382:microbiology / Q000601:surgery
D000970:Antineoplastic Agents