Non-starch polysaccharides extracted from seaweed can modulate intestinal absorption of glucose and insulin response in the pig.
We have investigated the possible effects of algal polysaccharides on postprandial blood glucose and insulin responses in an animal model, the pig. Three seaweed fibres of different viscosities, extracted from Palmaria palmata (PP), Eucheuma cottonii (EC), or Laminaria digitata (LD), were compared to purified cellulose (CEL). Blood glucose and plasma insulin levels were monitored and intestinal absorption quantified for 8 h following a high carbohydrate test-meal supplemented with 5% fibre. Digestive contents were also sampled, 5 h postprandial. As compared to CEL, PP had no effect on glucose and insulin responses. The latter decreased with EC, but glucose absorption balance was not modified. LD addition resulted in a dramatically reduced glucose absorption balance, accompanied by a higher amount of starch left in the small intestine. Among polysaccharides tested, only the highly viscous alginates could affect intestinal absorption of glucose and insulin response.
Vaugelade
P
P
LNSA, INRA, Jouy-en-Josas, France.
Hoebler
C
C
Bernard
F
F
Guillon
F
F
Lahaye
M
M
Duee
P H
PH
Darcy-Vrillon
B
B
D000818:Animals; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism*; D001826:Body Fluids / Q000737:chemistry; D002339:Carotid Arteries; D004064:Digestive System / Q000378:metabolism; D005502:Food; D005947:Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D011169:Portal Vein; D012624:Seaweed / Q000737:chemistry*; D013213:Starch / Q000032:analysis; D013552:Swine; D014783:Viscosity
D001786:Blood Glucose; D007328:Insulin; D011134:Polysaccharides; D013213:Starch; D005947:Glucose