Diagnosis of polycystic ovary disease in obese women with a 24-hour hormone profile after buserelin stimulation.
OBJECTIVE
To evaluate the 24-hour hormone response to GnRH agonist stimulation in the diagnosis of polycystic ovary disease (PCOD) in obese women.


METHODS
Forty-three obese PCOD patients and 23 controls were randomized to 1 mg buserelin (BSRL) stimulation (PCOD group P-1, n = 31; control group C-1, n = 12) or 0.1 mg (PCOD group P-0.1, n = 12; control group C-0.1, n = 11).


RESULTS
Whereas following 1 mg BSRL administration, serum levels of 17 hydroxyprogesterone (17OHP), delta 4 androstenedione, estradiol (E2) and luteinizing hormone increment (delta LH) as well as the delta LH/delta follicle stimulating hormone ratio were all higher in group P-1 than in group C-1 (P < .001, < .01, < .01, = .08 and < .001, respectively), only 17OHP and E2 serum levels were higher in group P-0.1 than in group C-0.1 (P < .001, and = .01, respectively). Whereas 24-hour LH inversely correlated with body mass index (r = .37, P = .04), 24-hour hormone profile, and basal or glucose-stimulated serum insulin levels did not correlate in group P-1.


CONCLUSIONS
The 1-mg BSRL stimulation test is a convenient diagnostic means in obesity-associated PCOD. The hormone response to BSRL administration is related to obesity, not to insulin resistance.
Hagag
P
P
Endocrine Institute, Assaf Harofeh Medical Center, Zerifin, Israel.
Ben-Shlomo
A
A
Herzianu
I
I
Weiss
M
M
D000293:Adolescent; D000328:Adult; D002064:Buserelin; D005260:Female; D005300:Fertility Agents, Female; D012739:Gonadal Steroid Hormones / Q000032:analysis; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis* / Q000209:etiology; D012680:Sensitivity and Specificity
D005300:Fertility Agents, Female; D012739:Gonadal Steroid Hormones; D002064:Buserelin