title: Neighbourhood variation in incidence of schizophrenia. Evidence for person-environment interaction.
abstract: BACKGROUND
  Neighbourhood characteristics may influence the risk of psychosis, independently of their individual-level equivalents.
  
  
  OBJECTIVE
  To examine these issues in a multi-level model of schizophrenia incidence.
  
  
  METHODS
  Cases of schizophrenia, incident between 1986 and 1997, were identified from the Maastricht Mental Health Case Register. A multi-level analysis was conducted to examine the independent effects of individual-level and neighbourhood-level variables in 35 neighbourhoods.
  
  
  RESULTS
  Independent of individual-level single and divorced marital status, an effect of the proportion of single persons and proportion of divorced persons in a neighbourhood was apparent (per 1% increase respectively: RR = 1.02; 95% CI 1.00-1.03; and RR = 1.12, 95% CI 1.04-1.21). Single marital status interacted with the neighbourhood proportion of single persons, the effect being stronger in neighbourhoods with fewer single-person households.
  
  
  CONCLUSIONS
  The neighbourhood environment modifies the individual risk for schizophrenia. Premorbid vulnerability resulting in single marital status may be more likely to progress to overt disease in an environment with a higher perceived level of social isolation.
authors.affiliation: Department of Psychiatry and Neuropsychology, Maastricht University, European Graduate School of Neuroscience, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: van Os
authors.forename: G
authors.initials: G
authors.lastname: Driessen
authors.forename: N
authors.initials: N
authors.lastname: Gunther
authors.forename: P
authors.initials: P
authors.lastname: Delespaul
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012111:Residence Characteristics; D012559:Schizophrenia / Q000453:epidemiology*; D012737:Sex Factors; D012931:Social Environment; D012934:Social Isolation