title: Renal cortical neoplasms in long term survivors of solid organ transplantation.
abstract: BACKGROUND
  Renal cortical neoplasms have been reported after organ transplantation, but the level of risk as well as the histological features are poorly defined.
  
  
  METHODS
  A retrospective autopsy-based study was performed to evaluate renal neoplasms occurring in patients who underwent solid organ transplantation, died, and received an autopsy from 1981 to 1997 (383 liver, 125 heart, 52 lung, 39 heart/lung, 98 kidney, 4 bowel). Patients were divided into those with short (less than 101 days), medium (101 days to 5 years), and long-term survival (more than 5 years). The control group consisted of hospital autopsies on nontransplanted patients from the odd-numbered years, 1983 through 1997.
  
  
  RESULTS
  Renal cortical neoplasms were identified in 32/1325 of nontransplanted patients and 15/701 transplanted patients. In transplanted patients, neoplasms were identified in 14 native and 1 allograft kidney: 2/391 in short-term survivors, 3/234 in medium, and 10/76 in long term survivors. While transplant patients with short and medium length survival had no increased risk for neoplasms, patients with long-term survival showed a 9-fold increase in cortical neoplasms. Transplant patients with neoplasms averaged 47 years of age at death, significantly younger than the average age of 70 for nontransplanted control patients with renal neoplasms. The neoplasms in transplanted patients were all tubulopapillary, except for one clear cell neoplasm and ranged in size from 0.1 to 2 cm.
  
  
  CONCLUSIONS
  Long-term survivors of solid organ transplants have an 9-fold increased risk of developing tubulopapillary renal cortical neoplasms.
authors.affiliation: University of Pittsburgh Medical Center Presbyterian University Hospital, Department of Pathology, PA 15213, USA.
authors.forename: M
authors.initials: M
authors.lastname: Torbenson
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Nichols
authors.forename: P
authors.initials: P
authors.lastname: Randhawa
authors.forename: M A
authors.initials: MA
authors.lastname: Nalesnik
mesh_terms: D005260:Female; D006801:Humans; D015994:Incidence; D007672:Kidney Cortex; D007679:Kidney Medulla; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000209:etiology; D007684:Kidney Tubules; D008297:Male; D016377:Organ Transplantation; D010414:Pennsylvania; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors