Study of a molecular imprinting polymer coated BAW bio-mimic sensor and its application to the determination of caffeine in human serum and urine.
A bio-mimic bulk acoustic wave (BAW) sensor was fabricated by coating the caffeine (CAF) template molecular imprinting polymer (MIP). This sensor exhibited high selectivity and a sensitive mass response to CAF. The response range of the sensor was between 5.0 x 10(-9) and 1.0 x 10(-4) M with a detection limit of 5.0 x 10(-9) M at pH 8.0. Recoveries were 96.1-105.6%. Influencing factors were investigated in detail and optimized. When employed to detect real samples, the proposed method proved to be a convenient method with the advantages of high sensitivity, good selectivity and ease of handling.
Liang
C
C
College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
Peng
H
H
Bao
X
X
Nie
L
L
Yao
S
S
D015374:Biosensing Techniques; D002110:Caffeine / Q000032:analysis* / Q000097:blood / Q000652:urine; D006801:Humans; D012680:Sensitivity and Specificity
D002110:Caffeine