[The treatment of hirsutism in adolescent girls with spironolactone].
OBJECTIVE
The purpose of this study was to determine the antiandrogenic properties of spironolactone on hirsute adolescents.


METHODS
Thirty-four adolescents between 15-18 years were studied. The hirsute adolescents were treated with spironolactone from 4th to the 22d day of the menstrual cycle for 8 months.


RESULTS
Clinical improvement became evident usually 3 months after initiation of treatment. After 8 months, hirsutism has improved in 24 (70.6%) of 34 adolescents. A decrease in testosterone levels occurred in all patients, even those with initially normal values.


CONCLUSIONS
The encouraging results obtained with spironolactone suggest that it may proved to be the appropriate drug for treatment of hirsute adolescents.
Malinova
M
M
D000293:Adolescent; D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006628:Hirsutism / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D013148:Spironolactone / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D000726:Androgen Antagonists; D013148:Spironolactone