title: Design, synthesis, and antimicrobial activity of 6-O-substituted ketolides active against resistant respiratory tract pathogens.
authors.affiliation: Infectious Disease Research, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, Illinois 60064-3537, USA.
authors.forename: Y S
authors.initials: YS
authors.lastname: Or
authors.forename: R F
authors.initials: RF
authors.lastname: Clark
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: D T
authors.initials: DT
authors.lastname: Chu
authors.forename: A M
authors.initials: AM
authors.lastname: Nilius
authors.forename: R K
authors.initials: RK
authors.lastname: Flamm
authors.forename: M
authors.initials: M
authors.lastname: Mitten
authors.forename: P
authors.initials: P
authors.lastname: Ewing
authors.forename: J
authors.initials: J
authors.lastname: Alder
authors.forename: Z
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D004352:Drug Resistance, Microbial; D006193:Haemophilus influenzae / Q000187:drug effects*; D008168:Lung / Q000382:microbiology; D008171:Lung Diseases / Q000188:drug therapy; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D051381:Rats; D012141:Respiratory Tract Infections / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy; D013210:Staphylococcus / Q000187:drug effects*; D013290:Streptococcal Infections / Q000188:drug therapy; D013291:Streptococcus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides