Are childhood psychiatric histories of bipolar adolescents associated with family history, psychosis, and response to lithium treatment?
OBJECTIVE
To examine if childhood psychiatric diagnoses are associated with family history, psychosis, age, and lithium response.


METHODS
Associations among variables, and their contributions to explaining lithium response were examined in 48 bipolar adolescents enrolled in a study of lithium.


RESULTS
Presence of a childhood diagnosis was not associated with family psychiatric history or lithium response. Subjects with psychotic features, however, were less likely to have a childhood psychiatric diagnosis, were older, and had a poorer response rate to lithium than subjects without psychosis.


CONCLUSIONS
Heterogeneity within bipolar adolescents may be based on clinical features such as psychosis rather than childhood or family history alone.
Kafantaris
V
V
Division of Child and Adolescent Psychiatry, Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Coletti
D J
DJ
Dicker
R
R
Padula
G
G
Pollack
S
S
D000293:Adolescent; D018692:Antimanic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D002648:Child; D015897:Comorbidity; D004311:Double-Blind Method; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000235:genetics; D012307:Risk Factors; D016896:Treatment Outcome
D018692:Antimanic Agents; D016651:Lithium Carbonate