Biotransformation rates of Ugilec 141 (tetrachlorobenzyltoluenes) in rat and trout microsomes.
In vitro biotransformation rates of tetrachlorobenzyltoluene (TCBT) isomers 3,3',4,4'-Cl4-2-Me (TCBT 87), 3,3',4,4'-Cl4-5-Me (TCBT 88), and 3,3',4',5-Cl4-4-Me (TCBT 94) were determined using trout and rat hepatic microsomes. The disappearance of the TCBTs from the in vitro system followed first-order kinetics. The estimated biotransformation constants (k) for the rat ranged from 0.96 to 4.14 h(-1). Biotransformation rates for trout microsomes were much lower and ranged from 0.009 to 0.017 h(-1).
Kramer
H J
HJ
Research Institute of Toxicology, Utrecht University, The Netherlands. h.kramer@ritox.vet.uu.nl
van den Berg
M
M
Delang
R J
RJ
Brandsma
L
L
Dejongh
J
J
D000818:Animals; D001559:Benzhydryl Compounds / Q000493:pharmacokinetics*; D001711:Biotransformation; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D017686:Oncorhynchus mykiss; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
D001559:Benzhydryl Compounds; C063736:Ugilec 141