Metachronous carcinoma of the vulva and fallopian tube.
BACKGROUND
Metachronous carcinoma of the vulva and fallopian tube is an unusual co-occurrence of gynecological malignancies. A report of such a case that developed and recurred over a 7-year period is presented.


METHODS
A 53-year-old G3P3 female presented with a verrucous carcinoma of the vulva and a serous papillary adenocarcinoma of the left fallopian tube metachronously. To investigate a possible association between the co-occurrence of the rare neoplasms and factors associated with multiple gynecological malignancies, we analyzed the status of human papillomavirus infection and DNA mismatch repair deficiency as indicated by microsatellite instability. All samples analyzed were negative for these factors.


CONCLUSIONS
The present results support the possibility that metachronous carcinomas of the vulva and fallopian tube involve unknown etiological factors or arise independently.
Ichikawa
Y
Y
Department of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, 305-8575, Japan. yoichika@md.tsukuba.ac.jp
Tsunoda
H
H
Nishide
K
K
Nishida
M
M
Kubo
T
T
D000231:Adenocarcinoma, Papillary / Q000209:etiology / Q000473:pathology*; D018289:Carcinoma, Verrucous / Q000209:etiology / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005185:Fallopian Tube Neoplasms / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D018895:Microsatellite Repeats; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000209:etiology / Q000473:pathology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications; D014846:Vulvar Neoplasms / Q000209:etiology / Q000473:pathology*
D004273:DNA, Neoplasm