title: Recognition and management of Kawasaki disease.
abstract: Kawasaki disease is the leading cause of acquired heart disease in children in the developed world, with coronary artery aneurysms occurring in up to 25% of untreated cases. The mean annual incidence of Kawasaki disease across Canada is about 13 per 100,000 children less than 5 years of age, based on hospital discharge data from 1990 to 1995. The cause remains unknown, and the diagnosis is based on the same clinical criteria used to describe the disease over 30 years ago. However, nonspecific clinical features, evolving presentations and atypical or incomplete presentations make early diagnosis and timely treatment difficult. Delays in diagnosis and treatment, which occur more frequently in older children, are associated with an increased risk of coronary artery aneurysms. Hence, high diagnostic suspicion and prompt referral are required to reduce the rate of cardiac complications.
authors.affiliation: Division of Cardiology, University of Toronto, Ont.
authors.forename: R K
authors.initials: RK
authors.lastname: Han
authors.forename: B
authors.initials: B
authors.lastname: Sinclair
authors.forename: A
authors.initials: A
authors.lastname: Newman
authors.forename: E D
authors.initials: ED
authors.lastname: Silverman
authors.forename: G W
authors.initials: GW
authors.lastname: Taylor
authors.forename: P
authors.initials: P
authors.lastname: Walsh
authors.forename: B W
authors.initials: BW
authors.lastname: McCrindle
mesh_terms: D000293:Adolescent; D001241:Aspirin / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D006801:Humans; D007116:Immunization, Passive; D015994:Incidence; D007223:Infant; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D009864:Ontario / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors
chemical_list: D001241:Aspirin