title: Adult T-cell leukemia/lymphoma with initial deafness.
abstract: In July 1995, a 43-year-old Japanese man presented with deafness in the right ear. On hospital admission, he had deafness in both ears and right facial palsy. Variously sized lymphoid cells with convoluted nuclei were observed in the cerebrospinal fluid. Surface marker analysis revealed monoclonality of T lymphocytes in the spinal fluid. Similar abnormal cells were observed in peripheral blood and bone marrow. Biopsy specimens of the stomach and prostate showed tight proliferation of large lymphoid cells in the interstitium and epithelium. Antibody against human T-lymphotrophic virus type 1 (HTLV-1) was present. The diagnosis of non-Hodgkin's lymphoma, diffuse type, was made. Seven months later, the patient died of sepsis. Autopsy revealed multiple lymphadenopathy in the abdomen and the infiltration of atypical lymphocytes to the pancreas, kidneys, and other organs. A monoclonal band of HTLV-1 provirus was detected by Southern blot analysis. To our knowledge, this is the first report of adult T-cell leukemia/lymphoma with auditory nerve abnormalities as the initial symptom.
authors.affiliation: Third Department of Internal Medicine, Tokyo Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Shirota
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D003056:Cochlear Nerve / Q000473:pathology; D003638:Deafness / Q000097:blood / Q000209:etiology*; D005158:Facial Paralysis / Q000097:blood; D017809:Fatal Outcome; D006801:Humans; D020437:Hypoglossal Nerve Diseases / Q000097:blood; D007564:Japan; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000097:blood / Q000150:complications*; D008297:Male