Trypanosoma cruzi: parasitaemia produced in mice does not seem to be related to in vitro parasite-cell interaction.
The interaction of Trypanosoma cruzi strains producing subpatent or high parasitaemia in mice with mouse macrophages, Vero and L929 cells was evaluated using tissue culture trypomastigotes. Macrophages were the cells most readily infected while Vero cells presented the highest parasite intracellular multiplication rates. Subpatent strains were equal or more infective than the high parasitaemia. Due to the small number of strains, no correlation could be established between the zymodemes and parasitaemia or parasite-cell interaction in vitro. However parasitaemia in mice does not seem to be related to in vitro parasite-cell interaction.
Keiko Toma
H
H
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 30161-970, Rio de Janeiro, Brazil.
Penna Cerávolo
I
I
Guerra
H L
HL
Steindel
M
M
Romanha
A J
AJ
D000818:Animals; D002522:Chlorocebus aethiops; D004195:Disease Models, Animal; D006790:Host-Parasite Interactions; D066298:In Vitro Techniques; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D018512:Parasitemia / Q000469:parasitology*; D014349:Trypanosoma cruzi / Q000472:pathogenicity / Q000502:physiology*; D014709:Vero Cells