Metal ion-directed DNA recognition by chelating DNA ligands.
Novel DNA ligand bearing oxine and pyridinium group has been synthesized. The DNA binding of this ligand was regulated by coexisting Cu2+ over the range of more than three orders in magnitude of binding constant. This should be due to the metal-mediated dimerization of the ligand and concomitant emergence of cationic charges. There were definite two DNA binding modes for the ligand dimer depending on the P/L ratio.
Ihara
T
T
Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kumamoto University, Japan.
Ikegami
T
T
Sueda
S
S
Takagi
M
M
Jyo
A
A
D002614:Chelating Agents; D002942:Circular Dichroism; D003300:Copper; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D008024:Ligands; D009690:Nucleic Acid Conformation; D015125:Oxyquinoline; D011726:Pyridinium Compounds
D002614:Chelating Agents; D008024:Ligands; D011726:Pyridinium Compounds; D015125:Oxyquinoline; D003300:Copper; D004247:DNA