title: Pyoderma gangrenosum as an early revelator of acute leukemia.
abstract: Bullous pyoderma gangrenosum is an atypical, more superficial variety of the classical pyoderma and is often associated with myeloproliferative disorders. We present the case of a patient who presented initially with subcutaneous nodules and who developed bullous lesions afterwards. Histological evaluation showed the presence of neutrophilic infiltrates in both lesions. A few months after the diagnosis of bullous pyoderma gangrenosum, an underlying leukemia was revealed. Our case illustrates the importance of regular blood and bone marrow examinations in patients with atypical bullous pyoderma gangrenosum, resulting in a rapid diagnosis of the underlying disease.
authors.affiliation: Department of Dermatology, University Hospital Gent, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Beele
authors.forename: E
authors.initials: E
authors.lastname: Verhaeghe
authors.forename: A
authors.initials: A
authors.lastname: Stockman
authors.forename: A
authors.initials: A
authors.lastname: Janssens
authors.forename: L
authors.initials: L
authors.lastname: Noens
authors.forename: M L
authors.initials: ML
authors.lastname: Geerts
authors.forename: I
authors.initials: I
authors.lastname: Huys
authors.forename: J
authors.initials: J
authors.lastname: Naeyaert
mesh_terms: D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000473:pathology; D012867:Skin / Q000473:pathology