Alpha-adrenergic blockade in preventing posttransplant edema of lung allograft.
Effect of alpha-adrenergic blockers on pulmonary edema in lung transplantation was studied with a rat model of syngeneic left lung transplantation. Prior to harvesting, 0.1 mg of Prazosin or 0.4 mg of Yohimbine was given to the donor. Pulmonary and systemic hemodynamics were measured under the right pulmonary arterial occlusion (RPAO) at different time points after grafting. Wet to dry weight ratio (W/D) of all transplants was also calculated. Same procedure was conducted in rats with normal and ischemic lung and in transplanted animals without any treatments. While RPAO did not increase W/D in normal lung with a significant elevation in pulmonary arterial pressure (PAP), both these values significantly increased in transplanted lung. Transplanted animals could not tolerate RPAO 24 hours after grafting, but were tolerable later than 48 hours with elevated W/D and PAP. On the contrary, animals given Prazosin or Yohimbine were all tolerable at 24 hours postsurgery. Yohimbine significantly improved W/D. Consequently, it was demonstrated that pulmonary edema of the graft reached its peak during first 24 to 48 hours after transplantation and was alleviated by the blockade of alpha-adrenergic receptor in the graft vessel.
Kondo
T
T
Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. t-kondo@idac.tohoku.ac.jp
Horikoshi
A
A
Fujimura
S
S
Matsumura
Y
Y
Okada
Y
Y
Shimada
K
K
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D006333:Heart Failure / Q000209:etiology; D006439:Hemodynamics; D007511:Ischemia / Q000209:etiology; D008026:Ligation; D008168:Lung / Q000098:blood supply; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D011224:Prazosin / Q000627:therapeutic use*; D011651:Pulmonary Artery; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D011915:Rats, Inbred BUF; D013563:Sympathectomy, Chemical; D014655:Vascular Resistance; D015016:Yohimbine / Q000627:therapeutic use*
D000317:Adrenergic alpha-Antagonists; D015016:Yohimbine; D011224:Prazosin