[The study of candidates' genes in psychiatric diseases. I. Schizophrenia].
The study concerning the importance of genetic factors in etiopathogenesis of schizophrenia is presented below. In molecular genetics research there are two most frequently applied strategies: searching of the whole genome in order to find new genes; and molecular analysis of a candidate gene. Candidate gene analysis consist in choosing a gene which could theoretically have a connection with a given certain disease. The presented reference review includes the results of study concerning candidate genes analysis referring to biochemical hypothesis of schizophrenia. The aim of the study is to find changes at the level of nucleotide sequence in DNA, which have a connection with the disease. It was stated in many medical centres that in case of schizophrenia the polymorphism of gene's receptor D3 and gene's receptor 5HT2A can be of etiological importance. It was also proved that the clinical effect of clozapine could be connected with polymorphism of gene's receptor 5HT2A.
Hauser
J
J
Kliniki Psychiatrii Dorosłych AM w Poznaniu.
Czarny
M
M
D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050637:Receptors, Dopamine D3; D011985:Receptors, Serotonin / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D011985:Receptors, Serotonin