Epidemiology of herpesvirus papio infection in a large captive baboon colony: similarities to Epstein-Barr virus infection in humans.
The epidemiology of herpesvirus papio, a lymphocryptovirus similar to Epstein-Barr virus (EBV), was studied in a captive colony of >1900 baboons. Herpesvirus papio IgG antibody titers were measured by IFA. In total, 438 specimens from 296 baboons were assessed, including 116 serial specimens from 52 juveniles and 6 infants studied monthly for 1 year following birth and at age 18 months. Maternally derived antibody reached a nadir at 4 months of age. About 75% of animals at 12 months of age and >95% of animals after age 24 months demonstrated serologic evidence of herpesvirus papio infection. After age 3 years, the geometric mean titer was 1:60-75. The epidemiology of herpesvirus papio infection in baboons closely parallels that of EBV infection in humans. An animal model of lymphocryptovirus infection will facilitate investigations of human lymphocryptovirus biology.
Jenson
H B
HB
Departments of Pediatrics and Microbiology, University of Texas Health Science Center at San Antonio, 78229-3900, USA. jenson@uthscsa.edu
Ench
Y
Y
Gao
S J
SJ
Rice
K
K
Carey
D
D
Kennedy
R C
RC
Arrand
J R
JR
Mackett
M
M
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D018562:Disease Transmission, Infectious; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology* / Q000635:transmission; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008992:Monkey Diseases / Q000453:epidemiology* / Q000635:transmission; D010215:Papio; D016036:Seroepidemiologic Studies; D012919:Social Behavior
D000914:Antibodies, Viral