title: [The dynamic of biochemical stress reaction inductors in various tactics for surgical treatment of patients with a combined trauma of cranium and lower limbs ].
abstract: In 31 patients after a craniocerebral trauma combined with a trauma of locomotor system (CCCT), and in 28 patients with only a limb fractures a time course (1, 3, 7, and 14 days) of biochemical stress reaction inductors (cortisol, serotonin, histamine, lipid peroxidation products) in various tactics of surgical treatment was studied. It was established that CCCT in a significantly stronger degree increases cortisol and lipid peroxidation products' levels than an isolated locomotor system trauma. An early postponed surgical intervention in lower extremities in CCCT results in the same increase in the biochemical stress reaction inductors as a late postpone surgical intervention in the lower extremities. In an early postponed osteosynthesis in CCCT patients, a mean term of hospital stay was 67 days, and in a late postponed one 117 days. The disability period was correspondingly 200 vs 315 days.
authors.affiliation: N.V. Sklifosovsky Institute for Emergency Medicine, Moscow.
authors.forename: V V
authors.initials: VV
authors.lastname: Lebedev
authors.forename: P P
authors.initials: PP
authors.lastname: Golikov
authors.forename: B V
authors.initials: BV
authors.lastname: Davydov
authors.forename: K I
authors.initials: KI
authors.lastname: Rakhimi
authors.forename: A G
authors.initials: AG
authors.lastname: Suvalian
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Nikolaeva
authors.forename: N V
authors.initials: NV
authors.lastname: Fedorova
authors.forename: V V
authors.initials: VV
authors.lastname: Marchenko
mesh_terms: D006259:Craniocerebral Trauma / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D006632:Histamine / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007869:Leg Injuries / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D015227:Lipid Peroxidation; D012701:Serotonin / Q000097:blood; D013313:Stress Disorders, Post-Traumatic / Q000097:blood*; D013514:Surgical Procedures, Operative
chemical_list: D012701:Serotonin; D006632:Histamine; D006854:Hydrocortisone