title: Long-term safety of an early ACE-inhibitor treatment of patients with acute myocardial infarction: results of the 3 year follow-up period on 696 Swiss patients randomized to the ISIS-4 trial. ISIS-Switzerland Study Group.
abstract: Several large scale clinical trials showed that early ACE inhibitor treatment in patients with acute myocardial infarction reduced 30-day mortality. While the short-term evidence of benefit and risks appears to be consistent among trials, scarce data are available with respect to the long-term effects of short-term treatments. This study shows that the early reduction in mortality rate observed among patients treated with captopril persists for up to 3 years. This suggests that the benefit achieved in the acute phase in not lost even after a long period of time.
authors.affiliation: Clinica Medica Ospedale Civico, Lugano, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Genoni
authors.forename: R
authors.initials: R
authors.lastname: Malacrida
authors.forename: F
authors.initials: F
authors.lastname: Sessa
authors.forename: P
authors.initials: P
authors.lastname: Siegrist
authors.forename: A P
authors.initials: AP
authors.lastname: Maggioni
authors.forename: T
authors.initials: T
authors.lastname: Moccetti
mesh_terms: D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D009204:Myocardial Revascularization; D012008:Recurrence; D016019:Survival Analysis; D013557:Switzerland
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril