The controlled release of a drug from biodegradable chitosan gel beads.
Chitosan (CS) forms a gel in solutions with a pH above 12, and the gelation occurs at pH of about 9 in 10% amino acid solutions. In this paper, we investigated the enzymatic degradation and the drug release profile of this novel CS gel beads. The degradability of the CS gel beads was affected by the CS properties, e.g. the degree of deacetylation. The release of prednisolone (PS), as a model drug, from the CS gel beads was sustained significantly compared with the gel prepared with NaOH only. However, the release was not able to be sustained by the increment of NaOH concentration in the solution employed for the preparation of CS gel beads. We also investigated the control of drug release from CS gel beads by application of a complex formed between chondroitin sulfate (Cho) and CS. The release of PS from the CS gel beads treated with Cho was prolonged, and the release pattern was not affected by the treatment time. The time to 50% drug release was about 5 min with PS powder, about 200 min in CS gel beads with 10% glycine (Gly) (pH 9.0), and about 330 min in the CS gel beads with 10% Gly (pH 9.0) treated with Cho. Thus CS gel beads appear promising as a vehicle for sustained drug delivery, and the degradation of CS gel beads may be controlled by the degree of deacetylation of CS.
Kofuji
K
K
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
Ito
T
T
Murata
Y
Y
Kawashima
S
S
D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D012996:Solutions
D003692:Delayed-Action Preparations; D005782:Gels; D012996:Solutions; D002686:Chitin; D048271:Chitosan