The effects of acute nicotine on the body temperature and striatal dopamine metabolism of mice during chronic nicotine infusion.
The effects of acute nicotine administration on body temperature and striatal dopamine metabolism of mice during chronic subcutaneous nicotine infusion were investigated. On the 7th day of nicotine infusion the hypothermic effect of 1 mg/kg nicotine s.c. but not that of 2 mg/kg was weakened suggesting that tolerance developing to nicotine's hypothermic effect during chronic nicotine can be overcome by increasing the dose of nicotine. In saline-infused control mice 1 mg/kg nicotine increased striatal 3, 4-dihydroxyphenylacetic acid (DOPAC) but not homovanillic acid (HVA) concentration whereas 2 mg/kg increased both DOPAC and HVA. On the 7th day of nicotine infusion DOPAC and HVA concentrations were similar to control; and acute nicotine did not increase them suggesting that nicotinic acetylcholine receptors (nAChRs) regulating striatal dopamine metabolism were desensitized. The results suggest that the nAChRs mediating nicotine's effects on thermoregulation and brain dopamine metabolism differ.
Salminen
O
O
Division of Pharmacology and Toxicology, Department of Pharmacy, P.O. Box 56, FIN-00014 University of, Helsinki, Finland. outi.salminen@helsinki.fi
Ahtee
L
L
D000818:Animals; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology*; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004361:Drug Tolerance / Q000502:physiology; D007260:Infusion Pumps; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D017072:Neostriatum / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009538:Nicotine / Q000008:administration & dosage* / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism
D018722:Nicotinic Agonists; D011978:Receptors, Nicotinic; D009538:Nicotine; D004298:Dopamine