Synthesis of S-adenosyl-L-homocysteine hydrolase inhibitors and their biological activities.
Several nucleosides have been prepared as a possible inhibitor of human S-adenosyl-L-homocysteine (SAH) hydrolase for the development of anti-viral agents. Recently, SAH hydrolase has been considered as an attractive target for parasite chemotherapy for malaria. We report synthesis of several nucleosides including carbocyclic nucleosides and their inhibitory activities against recombinant malaria and human SAH hydrolases.
Kitade
Y
Y
Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan.
Kozaki
A
A
Gotoh
T
T
Miwa
T
T
Nakanishi
M
M
Yatome
C
C
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives*; D043383:Adenosylhomocysteinase; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D006867:Hydrolases / Q000037:antagonists & inhibitors*
C122097:9-(3'-formyl-2,'3'-dihydroxypropyl)adenine; D000962:Antimalarials; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000225:Adenine; D000241:Adenosine