title: Familial arteriovenous malformations in siblings.
abstract: BACKGROUND
  Familial arteriovenous malformations (AVMs) of the brain are rare. We present two sisters with the same parents who harbored AVMs that were successfully treated.
  
  
  METHODS
  The elder sister presented with a unilateral migrainous type of headache overlying the right parietal area. The younger one suffered from exercise-induced headaches. Both were neurologically intact. Magnetic resonance imaging scans of the brain and cerebral angiography delineated the lesions. Both sisters underwent endovascular embolization followed by surgical resection.
  
  
  RESULTS
  Postoperatively, aside from a left inferior quadrantanopsia in the elder sister, both were neurologically intact.
  
  
  CONCLUSIONS
  We report the rare occurrence of familial AVMs in two siblings and review the literature of 14 reports. No genetic predisposition was found.
authors.affiliation: Department of Radiology, Section of Interventional Neuroradiology, New York University Medical Center, New York, New York 10016, USA.
authors.forename: T
authors.initials: T
authors.lastname: Kamiryo
authors.forename: P K
authors.initials: PK
authors.lastname: Nelson
authors.forename: A
authors.initials: A
authors.lastname: Bose
authors.forename: P
authors.initials: P
authors.lastname: Zalzal
authors.forename: J J
authors.initials: JJ
authors.lastname: Jafar
mesh_terms: D000293:Adolescent; D000328:Adult; D002533:Cerebral Angiography; D003131:Combined Modality Therapy; D003399:Craniotomy; D004200:Diseases in Twins / Q000235:genetics*; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009679:Nuclear Family