title: [Experimental carbon disulfide-induced encephalopathy].
abstract: The histopathological and ultrastructural aspects of cerebral cortex were followed up in the white rat injected intraperitoneally with carbon disulphide at 5 mg/kg body weight/week, in a chronic experiment--3, 6, 10 months. Important neuronal damages like: neuronal dystrophy's to neurolysis affecting the pyramidal and granular cells, neuronophagy, nodular and diffuse glial reaction, in the absence of atherosclerotic lesions were noticed. The lesions developed after 3 months and become more extended at 6 months and 10 months: it persists even after 2 months from the moment when the administration ceased.
authors.affiliation: Disciplina de Medicină Muncii, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: C
authors.initials: C
authors.lastname: Mihalache
authors.forename: G
authors.initials: G
authors.lastname: Mihalache
authors.forename: L I
authors.initials: LI
authors.lastname: Mihalache
authors.forename: A
authors.initials: A
authors.lastname: Indrei
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology; D002246:Carbon Disulfide / Q000008:administration & dosage / Q000633:toxicity*; D002540:Cerebral Cortex / Q000187:drug effects / Q000648:ultrastructure; D004195:Disease Models, Animal; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors
chemical_list: D002246:Carbon Disulfide