[Clinical and metabolic effects of oral contraceptives].
The oral contraception most employed, consists in a combination of estrogen and progestin, the main action in the prevention of ovulation through the inhibition of the secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH). The progestin in combination with estrogen produces an endometrium not receptive to the oocyte implantation and changes tubal, this affects capacitation and acrosomal reaction. Since 1960s up to date the reports made had been established that the OC had been developed adverse effects such as increase concentration of HDL, increase of apolipoprotein B-100, insulin resistance, increase in SHBG, atherogenicity, alteration in the coagulation factors and increase in the risk of venous thromboembolic disease. This work was elaborated with literature search on MEDLINE between 1985 to 1998, with the purpose to search the collateral effects of Oral Contraceptives evaluated by other authors.
Vázquez Hernández
L
L
Hospital de Ginecología y Obstetricia Luis Castelazo Ayala IMSS, México.
Téllez Martínez
J
J
Hicks Gómez
J J
JJ
D000273:Adipose Tissue / Q000187:drug effects; D000328:Adult; D000367:Age Factors; D001659:Biliary Tract / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D050260:Carbohydrate Metabolism; D002318:Cardiovascular Diseases / Q000139:chemically induced; D002319:Cardiovascular System / Q000187:drug effects; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D003280:Contraceptives, Oral, Synthetic / Q000009:adverse effects; D017135:Desogestrel / Q000009:adverse effects; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008074:Lipoproteins / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D045167:Progesterone Congeners / Q000009:adverse effects; D011372:Progestins / Q000009:adverse effects; D012307:Risk Factors; D012867:Skin / Q000187:drug effects; D013927:Thrombosis / Q000139:chemically induced
D001779:Blood Coagulation Factors; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D003280:Contraceptives, Oral, Synthetic; D004967:Estrogens; D008074:Lipoproteins; D045167:Progesterone Congeners; D011372:Progestins; D017135:Desogestrel