[Molecular biological and clinical-morphological studies of gastric tumors associated with Epstein-Barr virus].
The paper presents the results of the studies of gastric cancer (GC) associated with Epstein-Barr virus (EBV) among the patients residing in 4 geographical regions. In situ hybridization (ISH) techniques revealed that 49(11.4%) of the 430 examinees were EBV positive (EBV+), the virus-specific marker mRNA-1 of EBV, EBER-1) was found to be present in 80-100) of tumor cells. The proportion of EBV(+)-associated GC cases in different geographic regions ranged from 7.3 to 15%. These tumors were predominant in males (15%) as opposite to females (5.5%). Histological types most common among EBV+ tumors and their location in the stomach are also described. Serological findings indicated that the increased anti-EDV antibody response in 70% of GC cases coincided with the presence of the viral genetic information detected by ISH. In contrast to a humoral response to EBV, a humoral response to Helicobacter pylori was equal both in patients with EBV(+)- and EBV(-)-associated gastric tumors. Further molecular biological analysis of EBV isolates from virus positive and virus negative GC may answer the question whether there are really the so-called tumor and non-tumor variants of EBV.
Gurtsevich
V E
VE
Novikova
E V
EV
Borisova
E Iu
EIu
Stepina
V N
VN
Iakovleva
L S
LS
Davydov
M I
MI
Klimenkov
A A
AA
Nered
S N
SN
Frank
G A
GA
Kozlovskiĭ
O M
OM
Britvina
V A
VA
Petel'nikova
E S
ES
Petrovichev
N N
NN
Ruzabakiev
R M
RM
Tokunaga
M
M
Zaridze
D G
DG
D000230:Adenocarcinoma / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009031:Moscow / Q000453:epidemiology; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors; D012800:Siberia / Q000453:epidemiology; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000473:pathology
D000914:Antibodies, Viral; D012333:RNA, Messenger; D012367:RNA, Viral