Miscarriages and stillbirths in women with a high intake of fish contaminated with persistent organochlorine compounds.
OBJECTIVE
The purpose of the present study was to assess the effect, on miscarriages and stillbirths, of persistent organochlorine compounds (POC) through dietary intake of fatty fish from the Baltic Sea.


METHODS
Information on miscarriages and stillbirths was collected retrospectively by a self-administered questionnaire in a cohort of fishermen's wives from the Swedish east coast (by the Baltic Sea) and in a referent cohort of west coast fishermen's wives. Current fish consumption was used as a proxy for exposure within the east coast cohort.


RESULTS
No increase in miscarriages or stillbirths was found in the east coast cohort compared with the west coast group, in fact a decrease in early miscarriages was found (OR 0.48 [95% CI 0.26-0.92]). Moreover, no increase in risk was found for current high consumers of fatty fish within the east coast cohort.


CONCLUSIONS
The present data provided no evidence that dietary POC exposure increases miscarriage and stillbirth rates.
Axmon
A
A
Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, University Hospital, Lund, Sweden. anna.axmon@ymed.lu.se
Rylander
L
L
Strömberg
U
U
Hagmar
L
L
D000022:Abortion, Spontaneous / Q000139:chemically induced / Q000453:epidemiology*; D000818:Animals; D015331:Cohort Studies; D004032:Diet; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000453:epidemiology*; D005399:Fishes; D005506:Food Contamination; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000009:adverse effects* / Q000097:blood; D008019:Life Style; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides