Signal transduction by the TCR for antigen.
The past several years have seen the beginning of a shift in the way that TCR signal transduction is studied. Although many investigators continue to identify new molecules, particularly adaptor proteins, others have attempted to look at signaling events in a larger cellular context. Thus the identification of distinct formations of signaling molecules at junctions between T cells and antigen-presenting cells, the role of the cytoskeleton and the partitioning of molecules into specialized lipid subdomains have been the subjects of many publications. Such concepts are helping to assemble a blueprint of how the myriad adaptors and kinases fit together to effect T cell activation.
Kane
L P
LP
Department of Medicine, The Howard Hughes Medical Institute, University of California (San Francisco), San Francisco, CA 94143-0795, USA.
Lin
J
J
Weiss
A
A
D017951:Antigen Presentation; D018448:Models, Immunological; D008961:Models, Structural; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D014157:Transcription Factors / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors; D011505:Protein-Tyrosine Kinases