title: [Early relapse of herpes simplex encephalitis. Clinical and therapeutic implications].
abstract: A case of Herpes simplex virus encephalitis (HSVE) is reported in a 5 year old boy, who relapsed twice during the acute phase of the disease. The second relapse was completely cured by increasing the daily treatment with acyclovir to a dosage of 60 mg/kg intravenously for two weeks and 30 mg/kg by mouth for a further week. The full disappearance of the symptoms and the regression of cerebral lesions could be correlated to a prompt diagnosis and to the dosage of acyclovir employed, higher than that suggested for diseases caused that was by other members of the Herpes virus family.
authors.affiliation: Dipartimento di Pediatria, Università degli Studi, Catania.
authors.forename: P
authors.initials: P
authors.lastname: Pavone
authors.forename: G L
authors.initials: GL
authors.lastname: Trobia
authors.forename: M
authors.initials: M
authors.lastname: Ruggieri
authors.forename: F
authors.initials: F
authors.lastname: Greco
authors.forename: A
authors.initials: A
authors.lastname: D'Agata
authors.forename: S
authors.initials: S
authors.lastname: Musumeci
mesh_terms: D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D020803:Encephalitis, Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence