title: Sesquiterpene alkaloids from Tripterygium hypoglaucum and Tripterygium wilfordii: a new class of potent anti-HIV agents.
abstract: Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Duan
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Y
authors.initials: Y
authors.lastname: Imakura
authors.forename: Y
authors.initials: Y
authors.lastname: Jia
authors.forename: D
authors.initials: D
authors.lastname: Li
authors.forename: L M
authors.initials: LM
authors.lastname: Cosentino
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000470:Alkaloids; D019380:Anti-HIV Agents; D012717:Sesquiterpenes