title: [Severe craniocerebral trauma in multiple trauma. An assessment of the interaction of local and systemic mediator responses].
abstract: Isolated severe head trauma (SHT) or SHT in combination with multiple injuries are important factors for the prognosis of morbidity and mortality in patients suffering from the consequences of accidents. The prognosis mainly depends on the presence of primary mechanic brain injury and the development of secondary brain damage. Causes for the development of secondary brain damage are the intracranial space demand after traumatic injury and edema formation which may result in iscemia, as well as inflammatory processes. Both isolated SHT and polytrauma with or without brain damage may result in a systemic inflammatory response syndrome (SIRS) due to the synthesis of cytokines and other inflammatory mediators which may cause a single or multiple organ failure (MOF). Often the organism is able to survive isolated traumatic injuries and functional disturbances, but in combination or cumulation they may be lethal. The hypermetabolism after SHT is often regarded as an interaction between the central nervous system and the whole organism by the activation of the neuroendocrine axis. In contrast to the consequences of SHT for the whole organism, multiple injuries after polytrauma may affect brain functions, such as the shock dependent disturbance of the brain perfusion accompanied by brain hypoxia which may lead to an aggravated prognosis. Moreover, coagulation, metabolism and fracture healing are influenced by the onset of SIRS as well. Our knowledge about the bidirectional inflammatory interaction between brain and whole organism is still limited. In this context, the effects of secondary surgical interventions which may additionally, stress a traumatized body have to be considered and are the subject for actual clinical discussions and experimental studies. This article tries to summarize some important aspects on this topic.
authors.affiliation: Biochemische und Experimentelle Abteilung, Universität zu Köln. eddy.Neugebauer@uni-koeln.de
authors.forename: E
authors.initials: E
authors.lastname: Neugebauer
authors.forename: T
authors.initials: T
authors.lastname: Hensler
authors.forename: S
authors.initials: S
authors.lastname: Rose
authors.forename: B
authors.initials: B
authors.lastname: Maier
authors.forename: M
authors.initials: M
authors.lastname: Holanda
authors.forename: M
authors.initials: M
authors.lastname: Raum
authors.forename: D
authors.initials: D
authors.lastname: Rixen
authors.forename: I
authors.initials: I
authors.lastname: Marzi
mesh_terms: D001930:Brain Injuries / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D009102:Multiple Organ Failure / Q000401:mortality / Q000503:physiopathology; D009104:Multiple Trauma / Q000401:mortality / Q000503:physiopathology*; D011379:Prognosis; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000401:mortality / Q000503:physiopathology*
chemical_list: D018836:Inflammation Mediators