title: Apoptosis-inducing activity of galloyl monosaccharides in human histiocytic lymphoma U937 cells.
abstract: Three galloyl monosaccharides contained in medicinal plants were examined for apoptosis-inducing activity in human histiocytic lymphoma U937 cells. Tetragalloyl glucose (TgG) induced apoptosis as found by chromatin condensation, DNA ladder formation, and inhibition by a caspase inhibitor. Digalloyl hamamelose had moderate activity, while monogalloyl glucose was only marginally active. These findings suggest that the number and disposition of their phenolic groups are important for apoptosis induction. TgG induced apoptosis in human colon and stomach cancer cell lines as well, indicating it is potentially useful as an anti-cancer agent.
authors.affiliation: School of Food and Nutritional Sciences, University of Shizuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Saeki
authors.forename: S
authors.initials: S
authors.lastname: Hayakawa
authors.forename: T
authors.initials: T
authors.lastname: Noro
authors.forename: T
authors.initials: T
authors.lastname: Miyase
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Tanji
authors.forename: S
authors.initials: S
authors.lastname: Kumazawa
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: M
authors.initials: M
authors.lastname: Isemura
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D005707:Gallic Acid / Q000737:chemistry; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D009005:Monosaccharides / Q000737:chemistry / Q000494:pharmacology*; D020298:U937 Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009005:Monosaccharides; D005707:Gallic Acid