title: Efficacy of oral adsorbent for treatment of peristomal fistula associated with Crohn's disease.
abstract: Perianal fistulae are frequently seen complications in Crohn's disease. Although surgical procedures such as Seton's method have been devised, many patients still suffer from fistulae that are resistant to conventional therapy. We administered oral adsorbent to a patient with disease Crohn's who had a complicated peristomal fistula that did not improve with conventional therapy. Six grams of oral adsorbent (AST-120) were added daily to a regimen of elemental diet therapy and prednisolone. The fistula gradually decreased in size after the administration of the oral adsorbent, and had healed completely after 40 days' treatment. There were no side effects from the oral adsorbent. This case report suggests that oral adsorbent is an effective treatment for peristomal fistula associated with Crohn's disease.
authors.affiliation: Second Department of Internal Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsujikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Araki
authors.forename: J
authors.initials: J
authors.lastname: Makino
authors.forename: K
authors.initials: K
authors.lastname: Uda
authors.forename: T
authors.initials: T
authors.lastname: Ihara
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Fujiyama
authors.forename: T
authors.initials: T
authors.lastname: Bamba
mesh_terms: D000284:Administration, Oral; D000327:Adsorption; D000328:Adult; D002244:Carbon / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D003424:Crohn Disease / Q000628:therapy*; D017577:Cutaneous Fistula / Q000188:drug therapy*; D006801:Humans; D007081:Ileostomy; D008297:Male; D010087:Oxides / Q000008:administration & dosage* / Q000009:adverse effects; D010289:Parenteral Nutrition, Total; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D010087:Oxides; D002244:Carbon; C040896:AST 120