title: [Protection of mice by carbamates cholinesterase inhibitors against poisoning by armin and its dependence on certain physico-chemical indicators].
abstract: A series of aminostigmin derivatives with various substituents at nitrogen in the second position of the pyridine ring, has been tested. The efficacy of preventing the death of mice poisoned by armine in five of the seven substances correlates with the constant of the rate of carbamylation of acetylcholinesterase in the in vitro experiments and with the hydrophobic nature. It is suggested that the phenomenon of protection of animals against the toxic effect of organophosphorous compounds involves the "leaving portion" of the molecule of carbamates.
authors.affiliation: Military Medicine Research Institute, Ministry of Defense, Russian Federation, St-Peterburg.
authors.forename: V B
authors.initials: VB
authors.lastname: Prozorovskiĭ
authors.forename: L V
authors.initials: LV
authors.lastname: Pavlova
authors.forename: I M
authors.initials: IM
authors.lastname: Suslova
authors.forename: A V
authors.initials: AV
authors.lastname: Sazonova
authors.forename: A V
authors.initials: AV
authors.lastname: Kokushkina
mesh_terms: D000818:Animals; D001138:Armin / Q000633:toxicity*; D002219:Carbamates / Q000737:chemistry / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D006801:Humans; D008297:Male; D051379:Mice; D011041:Poisoning / Q000517:prevention & control*; D011725:Pyridines; D011729:Pyridostigmine Bromide / Q000031:analogs & derivatives; D013329:Structure-Activity Relationship
chemical_list: D002219:Carbamates; D002800:Cholinesterase Inhibitors; D011725:Pyridines; C070102:aminostigmine; D001138:Armin; D011729:Pyridostigmine Bromide