Prenylated benzoic acid derivatives from Ferula kuhistanica.
Four new prenylated benzoic acid derivatives, kuhistanols A-D (1-4), along with one known compound, 3-farnesyl-p-hydroxybenzoic acid (5), have been isolated from the roots of the Uzbekistan medicinal plant, Ferula kuhistanica. Their structures were established on the basis of chemical and spectral evidence. Compound 4 showed a significant inhibitory effect on cytokine production in lipopolysaccharide-stimulated human peripheral mononuclear cells.
Chen
B
B
Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
Kawazoe
K
K
Takaishi
Y
Y
Honda
G
G
Itoh
M
M
Takeda
Y
Y
Kodzhimatov
O K
OK
Ashurmetov
O
O
D019661:Apiaceae / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D016207:Cytokines / Q000097:blood; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D013057:Spectrum Analysis
D001565:Benzoates; D016207:Cytokines; D008070:Lipopolysaccharides