Bipartite scaphoid with proximal pole osteonecrosis in a patient with Holt-Oram syndrome.
The Holt-Oram syndrome features a spectrum of upper limb abnormalities, including an abnormal shape of the scaphoid. Our report concerns a 19-year-old man with Holt-Oram syndrome and flattening and sclerosis of the proximal pole of a bipartite scaphoid. The initial ossification centre in the scaphoid was located distally at 8 years of age. By age 13, a pair of ossific centres were present. After an automobile accident at age 18, the proximal pole became sclerotic and then began to fragment over a 22-month period. Computed tomography confirmed the presence of two poles of the scaphoid and sclerosis and fragmentation of the proximal pole.
Tate
D E
DE
40202
Gupta
A
A
Kleinert
H E
HE
D000328:Adult; D002348:Carpal Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000473:pathology; D006801:Humans; D008297:Male; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013577:Syndrome