Reprogramming erythroleuekmia cells to terminal differentiation and terminal cell division.
In vitro differentiation of murine erythroleuekemia cells recapitulates many aspects of the erythroid terminal differentiation program, including hemoglobin synthesis and proliferation arrest. It also provides an opportunity to study the changes occurring during reprogramming of tumor cells into their normal differentiation program. This review is focused on the recent progress made in understanding the key events occurring during the reprogramming of erythroleukemia cells. We discuss the contributions of PU.1 to the block to terminal differentiation exhibited by the erythroleukemia cells as well as the role of GATA-1 in restoring normal differentiation. We also discuss the role of certain cell cycle regulators in the decision to resume normal differentiation and in the resulting terminal cell divisions and arrest.
Matushansky
I
I
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx NY 10461, USA.
Radparvar
F
F
Rekhtman
N
N
Skoultchi
A
A
D000818:Animals; D016923:Cell Death; D002454:Cell Differentiation; D002455:Cell Division; D051358:Cyclin-Dependent Kinase 4; D051361:Cyclin-Dependent Kinase 6; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D005057:Eukaryotic Cells / Q000473:pathology; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D051379:Mice; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins
D011518:Proto-Oncogene Proteins; D017346:Protein Serine-Threonine Kinases; C495902:Cdk4 protein, mouse; C495912:Cdk6 protein, mouse; D051358:Cyclin-Dependent Kinase 4; D051361:Cyclin-Dependent Kinase 6; D018844:Cyclin-Dependent Kinases