title: Kidney disease and silicosis.
abstract: OBJECTIVE
  To determine the prevalence of kidney disease in a cohort of individuals with silicosis.
  
  
  METHODS
  Review of medical records and questionnaires from patients reported to a state surveillance system for silicosis. Reporting of individuals with silicosis is required by state law. All individuals with silicosis reported as required by law to the State of Michigan. Individuals included in this article were reported from 1987 to 1995. Cases were reported by hospitals, physicians, the state workers' compensation bureau, or from death certificates. Only individuals who met the criteria for silicosis developed by the National Institute for Occupational Safety and Health (NIOSH) were included.
  
  
  RESULTS
  Medical records were reviewed of 583 individuals with confirmed silicosis. This was mainly a population of elderly men. Ten percent of the 583 silicotics were found to have some mention of chronic kidney disease, and 33% of the 283 silicotics who we had laboratory tests on had a serum creatinine level >1.5 mg/dl. An association between kidney disease and age and between kidney disease and race was found among this cohort of 583 silicotics. Individuals with silicosis were more likely to have a serum creatinine level >1.5 mg/dl than age- and race-matched controls. However, no relationship between duration of exposure to silica or profusion of scarring on chest X-ray and prevalence of kidney disease or elevated creatinine levels was found.
  
  
  CONCLUSIONS
  This study confirms previous case reports and epidemiologic studies of end-stage renal disease that found an association between kidney disease and exposure to silica. The epidemiologic data are conflicting on the mechanism by which silica causes kidney disease and are compatible with silica being able to cause kidney disease by both an autoimmune and direct nephrotoxic effect. Chronic kidney disease should be considered as a complication of silicosis.
authors.affiliation: Department of Medicine, Michigan State University, East Lansing, 48824-1316, USA. Rosenman@pilot.msu.edu
authors.forename: K D
authors.initials: KD
authors.lastname: Rosenman
authors.forename: M
authors.initials: M
authors.lastname: Moore-Fuller
authors.forename: M J
authors.initials: MJ
authors.lastname: Reilly
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008499:Medical Records; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012829:Silicosis / Q000453:epidemiology* / Q000276:immunology
chemical_list: D003404:Creatinine