[Effect of low doses of ionizing irradiation on viability of cortical thymocytes].
The cortical thymocytes of rats in whole organism, isolated lobes of thymus and cells suspension were exposed to ionizing radiation in a wide range of doses (0.1-200 cGy). In contrast to relatively high dose radiation (50-200 cGy), exposure to doses of 10 cGy resulted in cell death without DNA degradation. The level of doses lower than 10 cGy (0.5-5 cGy) induced thymocyte death which is independent of DNA degradation, RNA and protein synthesis. With decrease in radiation dose, the increase of latent period preceding cell death took place.
Sharetskiĭ
A N
AN
Russian Academy of Medical Science, Department of Radiation Immunology, Obninsk, Kaluga oblast, Russia.
Kulish
Iu S
IuS
Abramova
M R
MR
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002470:Cell Survival / Q000528:radiation effects; D053938:DNA Fragmentation / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000473:pathology* / Q000528:radiation effects*; D013950:Thymus Gland / Q000473:pathology / Q000528:radiation effects*