title: Bupropion-induced isolated impairment of sensory trigeminal nerve function.
abstract: Bupropion is increasingly used for nicotine withdrawal and in the treatment of major depression, especially in bipolar patients. We present the case of a 38-year-old female schizoaffective, rapid-cycling patient treated with bupropion for a depressive episode. After 4 weeks of successful treatment (300 mg/day), the patient developed a circumscribed unilateral impairment of sensory trigeminal nerve function. Symptoms completely recovered after discontinuation of bupropion. When re-exposed to bupropion, mild symptoms reappeared, leading to final discontinuation of bupropion. With this natural on-off-on-off design, a causative role of bupropion for trigeminal impairment in this patient can be assumed. To our knowledge, a similar side-effect of bupropion has not been described to date.
authors.affiliation: Department of Psychiatry, University of Munich, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Amann
authors.forename: B
authors.initials: B
authors.lastname: Hummel
authors.forename: H
authors.initials: H
authors.lastname: Rall-Autenrieth
authors.forename: J
authors.initials: J
authors.lastname: Walden
authors.forename: H
authors.initials: H
authors.lastname: Grunze
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy*; D016642:Bupropion / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D020433:Trigeminal Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion