Hypoinsulinemia may mediate the lowering of self-stimulation thresholds by food restriction and streptozotocin-induced diabetes.
7 days beyond cessation of insulin treatment) elevation of threshold in ad libitum fed rats and, more transiently, reversed the threshold-lowering effect of food restriction. Acute insulin treatment (3 mU, 15 min prior) also elevated threshold in food-restricted rats. These results are consistent with the hypothesis that insulin modulates sensitivity of a brain reward system and that hypoinsulinemia may be the common factor in food restriction and diabetes that accounts for the enhancement of perifornical LHSS.
Carr
K D
KD
Millhauser Laboratories, Department of Psychiatry, New York University, School of Medicine, 550 First Avenue, New York, NY, USA. kc16@is4.nyu.edu
Kim
G
G
Cabeza de Vaca
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S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D004435:Eating / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D007026:Hypothalamic Area, Lateral / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D007328:Insulin / Q000097:blood* / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D012653:Self Stimulation / Q000502:physiology*; D013311:Streptozocin / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D007328:Insulin; D013311:Streptozocin