Pepsin and the esophagus.
Esophagitis results from excessive exposure of the esophagus to gastric juice through an ineffective or dysfunctional lower esophageal sphincter mechanism. A possible role of pepsin in damaging the esophageal mucosa with consequent esophagitis may be examined directly by testing pepsin under various conditions in experimental models of esophagitis. Since gastric juice contains both acid and pepsin, all experiments examine separately effects of perfusion of the esophagus by acid without and with pepsin in various combinations. Acid perfusion alone at concentrations represented by pH 1.3 or above does not produce esophagitis. The addition of pepsin to acid between pH 1 and 3.5 causes considerable acute esophageal damage. Outside the proteolytic range, i.e., higher than pH 3.5, pepsin does not damage the esophagus. The damage caused by acidified pepsin may be made much worse by the further addition of aspirin or other NSAIDs, presumably by further breaking down mucosal barriers.
Hirschowitz
B I
BI
Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, 35294-0007, USA. bhirschowitz@gihep.uab.edu
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D004195:Disease Models, Animal; D004941:Esophagitis / Q000188:drug therapy / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000503:physiopathology; D005750:Gastric Juice / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism; D009853:Omeprazole / Q000627:therapeutic use; D010434:Pepsin A / Q000378:metabolism / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010434:Pepsin A; D009853:Omeprazole