title: Catalytic concepts for the enantioselective synthesis of alpha-amino and alpha-hydroxy phosphonates.
abstract: The enantioselective synthesis of alpha-amino- and alpha-hydroxy phosphonates by catalytic processes has attracted considerable interest in the last few years, not least because of the pharmaceutical interest in such compounds. This article contains a compilation of the asymmetric synthesis methods developed to date. The described synthetic routes are based on different catalytic concepts, namely, hydrogenation, reductions, dihydroxylation, aminohydroxylation, and hydrophosphonylation.
authors.affiliation: Department of Research and Development, Special and Fine Chemicals, SKW Trostberg AG, Germany. harald.groeger@skw.com
authors.forename: H
authors.initials: H
authors.lastname: Gröger
authors.forename: B
authors.initials: B
authors.lastname: Hammer
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D006880:Hydroxy Acids / Q000138:chemical synthesis*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004791:Enzyme Inhibitors; D006880:Hydroxy Acids; D063065:Organophosphonates