title: Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts.
abstract: BACKGROUND
  Existing thrombus can complicate percutaneous saphenous vein graft (SVG) intervention. Local delivery of thrombolytics has been used to reduce the thrombus burden often associated with these interventions. We sought to determine whether local delivery of a platelet glycoprotein IIb/IIIa inhibitor is feasible and can reduce thrombus burden before percutaneous SVG intervention.
  
  
  METHODS
  We performed a multicenter pilot study of abciximab (0.25 mg/kg) given by local delivery catheter before percutaneous intervention for de novo SVG stenoses followed by intravenous infusion. All patients (n = 58) had >/=60% stenosis and Thrombolysis In Myocardial Infarction (TIMI) grade >0 flow in an SVG of 3 to 4 mm in diameter. Percent diameter stenosis, TIMI thrombus grade, and TIMI flow grade were measured before and after delivery of abciximab and after intervention.
  
  
  RESULTS
  Median percent diameter stenosis improved from 69% to 45% (P =.0001) after local delivery, and TIMI thrombus grade >/=1 incidence reduced from 68% to 34% (P =.0001). TIMI flow grade was not significantly affected (P =.12). All patients had a successful intervention (</=50% residual stenosis).
  
  
  CONCLUSIONS
  Local abciximab delivery before percutaneous SVG intervention is associated with significantly reduced thrombus burden, significantly improved percent diameter stenosis, and excellent acute procedural results. Further studies of this approach are warranted to define its clinical utility.
authors.affiliation: Duke Clinical Research Institute, Durham, North Carolina, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Barsness
authors.forename: C
authors.initials: C
authors.lastname: Buller
authors.forename: E M
authors.initials: EM
authors.lastname: Ohman
authors.forename: E
authors.initials: E
authors.lastname: Schechter
authors.forename: A
authors.initials: A
authors.lastname: Pucillo
authors.forename: M A
authors.initials: MA
authors.lastname: Taylor
authors.forename: M J
authors.initials: MJ
authors.lastname: Miller
authors.forename: J S
authors.initials: JS
authors.lastname: Reiner
authors.forename: D
authors.initials: D
authors.lastname: Churchill
authors.forename: A B
authors.initials: AB
authors.lastname: Chandler
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Tommaso
authors.forename: L G
authors.initials: LG
authors.lastname: Berdan
authors.forename: N M
authors.initials: NM
authors.lastname: Wildermann
authors.forename: D
authors.initials: D
authors.lastname: Hasdai
authors.forename: D R
authors.initials: DR
authors.lastname: Holmes
mesh_terms: D000077284:Abciximab; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000911:Antibodies, Monoclonal / Q000008:administration & dosage* / Q000009:adverse effects; D017023:Coronary Angiography / Q000187:drug effects; D001026:Coronary Artery Bypass; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage* / Q000009:adverse effects; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D011292:Premedication; D015607:Stents; D016896:Treatment Outcome; D014680:Veins / Q000637:transplantation*
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D000077284:Abciximab