Chemodenervation of the rat hemilarynx with phenol.
In this study, the injection of phenol into the true vocal fold was evaluated on a rat model as a possible treatment for adductor spasmodic dysphonia. A 10% phenol solution was injected into the right true vocal fold. Quantitative measurement of vocal fold adductory force showed reduction to 35% of the preinjection value 3 months after injection (p < .05). Qualitative evaluation by videolaryngoscopy demonstrated maintenance of the normal vocal fold range of motion. Histologic studies showed a transient inflammatory infiltrate and myolysis, while the vocal fold mucosa and the cricoarytenoid joints remained undamaged. Further investigation into the potential use of phenol for treating spasmodic dysphonia is warranted.
Nguyen
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T
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, and the Veterans Administration Medical Center, St Louis, Missouri, USA.
Paniello
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RC
D000818:Animals; D003714:Denervation; D007267:Injections; D007821:Laryngeal Muscles; D007826:Laryngismus / Q000150:complications / Q000628:therapy; D007828:Laryngoscopy; D008297:Male; D019800:Phenol / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014628:Vagotomy; D014827:Vocal Cords / Q000294:innervation* / Q000473:pathology / Q000502:physiology; D014832:Voice Disorders / Q000209:etiology / Q000628:therapy
D019800:Phenol