Diuretic and natriuretic action of adrenomedullin administered intracerebroventricularly in conscious rats.
Intracerebroventricular administration of rat adrenomedullin (AM) to conscious hydrated or salt-loaded rats, resulted in a significant increase in urinary volume. The diuretic effect of adrenomedullin occurred during the 6-h period of urine collection and was most effective during the 3 and 6 h. Most remarkably, AM given IVT induced a dose-related increase in urinary sodium excretion at all periods of urine collection. In addition, AM induced significant kaliuresis. Our results strongly suggest that AM may play a significant role in the central regulation of fluid and electrolyte homeostasis, and that its diuretic and natriuretic effect may be, at least in part, centrally mediated.
Israel
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School of Pharmacy, Laboratory of Neuropeptides, Universidad Central de Venezuela, Caracas, Venezuela. astern88@hotmail.com
Diaz
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D053607:Adrenomedullin; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015740:Calcitonin Gene-Related Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D002536:Cerebral Arteries / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000008:administration & dosage
D010455:Peptides; D053607:Adrenomedullin; D012965:Sodium Chloride; D015740:Calcitonin Gene-Related Peptide