title: Good outcome of children with acute myeloid leukemia and t(8;21)(q22;q22), even when associated with granulocytic sarcoma: a report from a single institution in Argentina.
abstract: BACKGROUND
  The association between t(8;21) and granulocytic sarcoma (GS) is well known, but to the authors' knowledge the prognostic significance of GS in these patients has not been defined clearly.
  
  
  METHODS
  Between January 1990 and July 1999 174 children with acute myeloid leukemia were admitted to the study institution. Translocation (8;21) was identified in 20 patients (11.5%). Eighteen patients were evaluable for the current study and 8 presented with GS at the time of diagnosis (GS+).
  
  
  RESULTS
  The authors defined two groups of patients: those who were GS+ and those who were GS-. One patient in the GS+ group and two patients in the GS- group died during the induction phase of the study. Complete remission was achieved in seven patients in the GS+ group and eight patients in the GS- group. Two patients developed a recurrence in the GS+ group as did one patient in the GS- group. The event free-survival probability (the standard error) was 58% (18%) in the GS+ group and 70% (14%) in the GS- group. Localization of GS was in only one site in seven patients and at multiple sites in one patient. Patients with an epidural mass received local radiotherapy (one patient) or surgery (two patients). Two of these patients developed paraplegia as sequelae: one patient after surgery and one patient after radiotherapy. One patient with orbital GS received local radiotherapy because of progressive proptosis. The remaining four patients had a complete resolution of the GS with chemotherapy only.
  
  
  CONCLUSIONS
  In the current study of patients with t(8;21)(q22;q22), the presence of granulocytic sarcoma was not found to be an adverse prognostic factor. However, careful attention should be paid, especially to patients with an epidural site, to avoid sequelae. Chemotherapy appears to be the optimum treatment for these children.
authors.affiliation: Department of Hematology-Oncology, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
authors.forename: M S
authors.initials: MS
authors.lastname: Felice
authors.forename: P A
authors.initials: PA
authors.lastname: Zubizarreta
authors.forename: E M
authors.initials: EM
authors.lastname: Alfaro
authors.forename: M S
authors.initials: MS
authors.lastname: Gallego
authors.forename: A M
authors.initials: AM
authors.lastname: Cygler
authors.forename: D A
authors.initials: DA
authors.lastname: Rosso
authors.forename: J G
authors.initials: JG
authors.lastname: Rossi
authors.forename: F
authors.initials: F
authors.lastname: Sackmann-Muriel
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male; D011379:Prognosis; D014178:Translocation, Genetic; D016896:Treatment Outcome