title: Progressive biliary pathology associated with common pancreato-biliary channel.
abstract: A female infant who presented with transient obstructive jaundice and who was shown to have mild fusiform dilatation of the common bile duct at the age of 18 months was followed up with hepatobiliary ultrasound scans over a period of 17 years. Enlarging gallbladder polyps were identified during the last 2 years of follow-up, and endoscopic retrograde cholangio-pancreatography (ERCP) showed a common pancreato-biliary channel with minimal bile duct dilatation. A high concentration of pancreatic amylase was detected in the bile. Hepaticojejunostomy and cholecystectomy were performed. Histologically, the resected common bile duct showed fibrous thickening of the wall and loss of surface epithelium. Muscular hypertrophy and polypoid lesions, which were foci of cholesterosis, were identified in the gallbladder. There was a minimal lymphocytic infiltrate in the subepithelial connective tissue. This report documents a progressive change in the ultrasound appearances of the gallbladder and histological changes in the extrahepatic ducts secondary to a common pancreato-biliary channel and pancreato-biliary reflux.
authors.affiliation: Department of Paediatric Surgery, King's College Hospital, London, England.
authors.forename: P
authors.initials: P
authors.lastname: Pushparani
authors.forename: R G
authors.initials: RG
authors.lastname: Redkar
authors.forename: E R
authors.initials: ER
authors.lastname: Howard
mesh_terms: D000293:Adolescent; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003135:Common Bile Duct / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D005706:Gallbladder Neoplasms / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D010183:Pancreatic Ducts / Q000002:abnormalities* / Q000000981:diagnostic imaging; D011127:Polyps / Q000209:etiology* / Q000473:pathology / Q000601:surgery