title: Synthesis and antifungal activity of a ferrocene-fluconazole analogue.
abstract: A novel ferrocene fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations.
authors.affiliation: Laboratoire de Catalyse de Lille, Groupe de Synthèse Organométallique, UPRESA CNRS 8010, Ecole Nationale Supérieure de Chimie de Lille, Villeneuve d'Ascq, France. ch_biot@club-internet.fr
authors.forename: C
authors.initials: C
authors.lastname: Biot
authors.forename: N
authors.initials: N
authors.lastname: François
authors.forename: L
authors.initials: L
authors.lastname: Maciejewski
authors.forename: J
authors.initials: J
authors.lastname: Brocard
authors.forename: D
authors.initials: D
authors.lastname: Poulain
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D015725:Fluconazole / Q000737:chemistry / Q000494:pharmacology*; D000075163:Metallocenes; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
chemical_list: D000935:Antifungal Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D015725:Fluconazole; C004998:ferrocene