title: Serum immunoglobulins, IgG subclasses, isohemagglutinins and complement-3 levels in patients with thalassemia major.
abstract: Serum IgG, IgM, IgA, IgG subclasses (IgG1, G2, G3, G4), isohemagglutinins and complement-3 concentrations were measured in 23 beta-thalassemic patients suffering from recurrent infections. No significant abnormalities were found in these humoral immunity investigations, both in splenectomized and non-splenectomized patients. On the other hand, iron overload or repeated blood transfusions were not found to down-regulate the humoral immune system of thalassemic patients.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Vergin
authors.forename: N
authors.initials: N
authors.lastname: Kutukculer
authors.forename: N
authors.initials: N
authors.lastname: Cetingul
authors.forename: G
authors.initials: G
authors.lastname: Nisli
authors.forename: S
authors.initials: S
authors.lastname: Caglayan
authors.forename: S
authors.initials: S
authors.lastname: Oztop
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000378:metabolism*; D005260:Female; D006388:Hemagglutinins / Q000097:blood*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification*; D007136:Immunoglobulins / Q000097:blood*; D008297:Male; D013156:Splenectomy; D017086:beta-Thalassemia / Q000175:diagnosis / Q000276:immunology* / Q000601:surgery
chemical_list: D003176:Complement C3; D006388:Hemagglutinins; D007074:Immunoglobulin G; D007136:Immunoglobulins