title: 99Tcm-HMPAO leucocyte labelling in orofacial granulomatosis and gastrointestinal Crohn's disease in childhood and early adulthood.
abstract: Orofacial granulomatosis is a granulomatous inflammatory disorder, affecting the soft tissues of the face and mouth. The predominant feature is disfiguring lip swelling. Patients with this condition may be exhibiting a Type IV hypersensitivity reaction to dietary or environmental allergens, or these may be the orofacial manifestations of underlying gastrointestinal Crohn's disease. The results of 99Tcm-HMPAO leucocyte labelling of the gastrointestinal tract in 14 patients with orofacial granulomatosis and 15 patients with known gastrointestinal Crohn's disease are presented, indicating that this is a useful and non-invasive screening test for the identification of gastrointestinal Crohn's disease in paediatric and young adult patients presenting with orofacial granulomatosis.
authors.affiliation: University of Glasgow Dental School, UK. j.gibson@dental.gla.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Gibson
authors.forename: J B
authors.initials: JB
authors.lastname: Neilly
authors.forename: A P
authors.initials: AP
authors.lastname: Wray
authors.forename: T J
authors.initials: TJ
authors.lastname: Evans
authors.forename: J R
authors.initials: JR
authors.lastname: MacKenzie
authors.forename: J H
authors.initials: JH
authors.lastname: McKillop
mesh_terms: D000293:Adolescent; D000328:Adult; D000485:Allergens; D002648:Child; D003424:Crohn Disease / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D005512:Food Hypersensitivity; D006099:Granuloma / Q000000981:diagnostic imaging* / Q000209:etiology; D006801:Humans; D006967:Hypersensitivity; D007962:Leukocytes; D008297:Male; D009059:Mouth Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019690:Technetium Tc 99m Exametazime / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000485:Allergens; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime