title: Pancreas transplantation in type 1 diabetes: hope vs reality.
abstract: Pancreas transplantation can improve quality of life for patients with type 1 diabetes by eliminating hypoglycemic and hyperglycemic episodes, the need for insulin injections, frequent self-monitoring of blood glucose levels, and dietary restrictions. Increasing evidence suggests that it may slow the progression of long-term diabetic complications. On the other hand, patients risk the adverse effects of lifelong immunosuppression.
authors.affiliation: Department of General Surgery, Cleveland Clinic, OH 44195, USA. mayesj@ccf.org
authors.forename: J T
authors.initials: JT
authors.lastname: Mayes
authors.forename: V W
authors.initials: VW
authors.lastname: Dennis
authors.forename: B J
authors.initials: BJ
authors.lastname: Hoogwerf
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016381:Islets of Langerhans Transplantation; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D016035:Pancreas Transplantation; D011788:Quality of Life
chemical_list: D007166:Immunosuppressive Agents