title: Heparin-induced extracorporal low-density-lipoprotein precipitation (H.E.L.P.) to improve the recovery of hearing in patients with sudden idiopathic hearing loss.
abstract: The pathogenesis of sudden hearing loss (SHL) is still not well understood. Possible causes include increased blood viscosity, microthrombosis or altered blood flow. Hypercholesterolemia, hyperfibrinogenemia and increased platelet aggregation are frequently observed in patients with SHL. The aim of this study was to investigate whether drastic lowering of plasma cholesterol and fibrinogen by selective extracorporal apheresis could have a beneficial effect on hearing recovery in these patients. Seven patients with SHL were treated with an extracorporal procedure removing fibrinogen and cholesterol from plasma. Six of the seven patients showed an immediate improvement in auditory thresholds following a single treatment of heparin-induced low-density lipoprotein precipitation. These findings indicate for the first time that acute and drastic removal of plasma fibrinogen and low-density lipoproteins may be an effective clinical method for the treatment of patients with SHL.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Grosshadern, Ludwig Maximilians University of Munich, München, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Suckfüll
authors.forename: C
authors.initials: C
authors.lastname: Wimmer
authors.forename: B
authors.initials: B
authors.lastname: Jäger
authors.forename: K
authors.initials: K
authors.lastname: Schorn
authors.forename: J
authors.initials: J
authors.lastname: Thiery
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001309:Auditory Threshold; D001781:Blood Component Removal / Q000379:methods*; D011232:Chemical Precipitation; D002784:Cholesterol / Q000097:blood / Q000302:isolation & purification; D005112:Extracorporeal Circulation; D005260:Female; D005340:Fibrinogen / Q000302:isolation & purification / Q000378:metabolism; D006311:Hearing Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged
chemical_list: D000925:Anticoagulants; D008077:Lipoproteins, LDL; D005340:Fibrinogen; D006493:Heparin; D002784:Cholesterol