Total synthesis of fully acetylated N-acetylneuraminic acid (Neu5Ac), 2-deoxy-beta-Neu5Ac, and 4-epi-2-deoxy-beta-Neu5Ac from D-glucose
Sialic acid and its analogues have been synthesized using a salenCo(II) complex catalyzed hetero Diels-Alder reaction and oxidative azidation (CAN/NaN3) of silyl enol ether as the key steps.
Li
LS
State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
Wu
YL
Wu
Y