title: [Tiagabine in drug-resistant epilepsy in children: preliminary study].
abstract: The aim of the study was the presentation of our preliminary experiences and the data concerning the efficacy and safety of tiagabine in patients below the 12-th year of life. 4 cases of drug--resistant epilepsy--with partial complex attacks in 3 and simple in 1 (frontal epilepsy from supplementary motor area) with multiple seizures in the day were the subject of the study. Tiagabine add-one therapy to CBZ or to VPA was used. Initial period--the dose titration lasted 4 weeks. The stable dosis period amounted to 5 months. The effective dosis of tiagabine was 1 mg/kg/day. In 1 case the seizures completely disappeared and in 3 the frequency decreased to 2-4 times in comparison to frequency per day before the treatment. There were not any side-effects reported which would be the cause of the drug discontinuation.
  
  
  CONCLUSIONS
  Tiagabine appeared to be an effective and safe drug in resistant epilepsy in children below 12 years of age.
authors.affiliation: Klinika Neurologii Instytutu C.Z.M.P.
authors.forename: J
authors.initials: J
authors.lastname: Wendorff
authors.forename: M
authors.initials: M
authors.lastname: Popielarczyk
authors.forename: M
authors.initials: M
authors.lastname: Zubiel
authors.forename: D
authors.initials: D
authors.lastname: Sokołowska
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D009557:Nipecotic Acids / Q000627:therapeutic use*; D000078308:Tiagabine; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D009557:Nipecotic Acids; D000078308:Tiagabine