Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles.
Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles possessing a compact structure were active against HRV-2 and, consequently, presented a type B activity. In this paper, 3-(diethylamino)-5-phenylisoxazoles, which are structurally more elongated and related to Disoxaril, were synthesized in view to attempt type A activity against HRV-14. Unfortunately, all tested compounds were devoid of activity against HRV-14 (and HIV-1) or exhibited great toxicity.
Mazzei
M
M
Department of Pharmaceutical Sciences, University of Genova, Italy. mazzei@ermes.cba.unige.it
Dondero
R
R
Ledda
B
B
Demontis
F
F
Vargiu
L
L
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D015497:HIV-1 / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012229:Rhinovirus / Q000187:drug effects; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D007555:Isoxazoles; C045978:disoxaril