title: Sildenafil for psychotropic-induced sexual dysfunction in 31 women and 61 men.
abstract: Ninety-two outpatients (31 women, 61 men) who were treated with oral sildenafil for psychotropic-induced sexual dysfunction (PISD) completed ratings of their sexual functioning pre- and posttreatment. Both women and men reported significant improvements (p = .001) in all domains of sexual functioning, with 88% reporting improvement in overall sexual satisfaction. Significant improvements were reported regardless of psychotropic medication type. However, patients taking selective serotonin re-uptake inhibitors reported less improvement in arousal, libido, and overall sexual satisfaction than did other patients, whereas patients taking benzodiazepines reported significantly more improvement in libido and overall sexual satisfaction. Oral sildenafil may be an effective treatment for PISD.
authors.affiliation: Washington Psychiatric Center, Psychiatric Institute of Washington, DC 20016, USA. piwpsych@erols.com
authors.forename: A J
authors.initials: AJ
authors.lastname: Salerian
authors.forename: W E
authors.initials: WE
authors.lastname: Deibler
authors.forename: B J
authors.initials: BJ
authors.lastname: Vittone
authors.forename: S P
authors.initials: SP
authors.lastname: Geyer
authors.forename: L
authors.initials: L
authors.lastname: Drell
authors.forename: N
authors.initials: N
authors.lastname: Mirmirani
authors.forename: J A
authors.initials: JA
authors.lastname: Mirczak
authors.forename: W
authors.initials: W
authors.lastname: Byrd
authors.forename: S B
authors.initials: SB
authors.lastname: Tunick
authors.forename: M
authors.initials: M
authors.lastname: Wax
authors.forename: S
authors.initials: S
authors.lastname: Fleisher
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects; D005260:Female; D006801:Humans; D007989:Libido / Q000187:drug effects; D008297:Male; D010549:Personal Satisfaction; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D011619:Psychotropic Drugs / Q000009:adverse effects*; D011687:Purines; D012189:Retrospective Studies; D012737:Sex Factors; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011619:Psychotropic Drugs; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate