Long-term outcome of cognition and functional health after cerebral venous sinus thrombosis.
The authors examined cognition and functional health of 57 patients with sinus thrombosis 1 year or more after enrollment in a randomized trial of anticoagulant treatment or placebo. Eight patients died and two declined participation. Of the remaining 47 patients, 16 (35%) had cognitive impairments, 3 (6%) were dependent, 19 (40%) had symptoms that led to restrictions in lifestyle, and 19 (40%) could not resume their previous level of economic activity. Outcome after sinus thrombosis may be less favorable than reported previously, and was not significantly influenced by treatment.
de Bruijn
S F
SF
Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands. The Cerebral Venous Sinus Thrombosis Study Group.
Budde
M
M
Teunisse
S
S
de Haan
R J
RJ
Stam
J
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D002550:Cerebral Veins; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D004311:Double-Blind Method; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications / Q000188:drug therapy*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D016896:Treatment Outcome
D000925:Anticoagulants