[The efficacy of different salt diets and the modulation of the protective action of cerebrolysin in an experimental disturbance of the cerebral circulation].
Experiments on rats showed that long-term excess sodium chloride feeding increased the loss of animals as a result of the common carotid artery ligation. The effect is related to maximum decrease in the local cerebral blood flow and sharply pronounced brain swelling. The sodium chloride substitute giposol reduced the extent of cerebral ischemia and produced antiswelling effect. On the background of the hyper-sodium-chloride diet, the protective action of cerebrolysine was less pronounced as manifested by decreasing survival of the test animals. In contrast, the administration of giposol increased the efficacy of cerebrolysine with respect to the carotid artery occlusion.
Shtrygol'
O Iu
OIu
Pharmacology and Clinical Pharmacology Chair, State Medical Academy, Ivanovo, Russia.
Sadin
A V
AV
Konkina
E A
EA
Branchevskiĭ
L L
LL
D000596:Amino Acids / Q000627:therapeutic use*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D001929:Brain Edema / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000209:etiology / Q000401:mortality; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D008278:Magnesium Sulfate / Q000627:therapeutic use; D018697:Nootropic Agents / Q000627:therapeutic use*; D011189:Potassium Chloride / Q000627:therapeutic use; D051381:Rats; D012965:Sodium Chloride / Q000627:therapeutic use; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage*
D000596:Amino Acids; D004338:Drug Combinations; C094275:Hyposol; D018697:Nootropic Agents; D017673:Sodium Chloride, Dietary; C006952:cerebrolysin; D012965:Sodium Chloride; D011189:Potassium Chloride; D008278:Magnesium Sulfate