Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation.
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), is a seleno-organic compound which protects tissues against oxidative stress. Furthermore, recent data has suggested that this compound possesses a range of anti-inflammatory properties. In this study the authors have investigated the effects of ebselen on Sephadex-induced lung oedema and bronchoalveolar lavage (BAL) tumour necrosis factor (TNF)-alpha and endothelin(ET)-1 levels in rats. Sephadex administration induced lung oedema which was accompanied by an increase in BAL TNF-alpha and ET-1 levels. Ebselen administration (1-30 mg x kg(-1), i.p. at 0, 4 and 12 h post Sephadex) significantly inhibited lung oedema (dose that produced 50% of the maximum inhibition of lung oedema 4.6 mg x kg(-1)) and BAL TNF-alpha levels in a dose-related manner with no effect on ET-1 levels. These data suggest that ebselen may be a useful therapy in lung pathologies in which bronchiolar inflammation is a feature.
Belvisi
M G
MG
Aventis Pharma, Pharmacology Dept, Dagenham Research Centre, Essex, UK.
Haddad
E B
EB
Battram
C
C
Birrell
M
M
Foster
M
M
Webber
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001393:Azoles / Q000627:therapeutic use*; D003911:Dextrans; D054833:Isoindoles; D008297:Male; D016566:Organoselenium Compounds / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001393:Azoles; D003911:Dextrans; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; C025614:sephadex