title: Uncommon metastasis of a glioblastoma multiforme in liver and spleen.
abstract: A case of a glioblastoma multiforme is presented. Craniotomy was performed with total resection of the right temporal tumor. Postoperatively, the patient received adjuvant radiotherapy, but 6 months after therapy he developed severe nausea and weight loss. Recurrence of an intracranial tumor in the right temporal region with nodules in the liver and spleen were detected by CT scan. Fine-needle biopsies of the liver confirmed the diagnosis of a glioblastoma metastasis with characteristic immunohistochemical staining for glial fibrillary acidic protein. This rare case of an intracerebral glioblastoma metastasizing to liver and spleen was managed by systemic chemotherapy.
authors.affiliation: Department of Gastroenterology and Hepatology, Hannover Medical School, Germany. Widjaja.Adji@mh-hannover.de
authors.forename: A
authors.initials: A
authors.lastname: Widjaja
authors.forename: H
authors.initials: H
authors.lastname: Mix
authors.forename: C
authors.initials: C
authors.lastname: Gölkel
authors.forename: P
authors.initials: P
authors.lastname: Flemming
authors.forename: R
authors.initials: R
authors.lastname: Egensperger
authors.forename: A
authors.initials: A
authors.lastname: Holstein
authors.forename: J
authors.initials: J
authors.lastname: Rademaker
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: M
authors.initials: M
authors.lastname: Hundt
authors.forename: S
authors.initials: S
authors.lastname: Wagner
authors.forename: M P
authors.initials: MP
authors.lastname: Manns
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D005909:Glioblastoma / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D013160:Splenic Neoplasms / Q000556:secondary*