The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.
The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological rôle of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.
Cole
C
C
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
Foster
A J
AJ
Freeman
S
S
Jaffar
M
M
Murray
P E
PE
Strafford
I J
IJ
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001711:Biotransformation; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009389:Neovascularization, Pathologic; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors / Q000502:physiology*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013939:Thymidine Phosphorylase