Synthesis and antibacterial studies of a new series of 1,2-bis(1,3, 4-oxadiazol-2-yl)ethanes and 1,2-bis(4-amino-1,2, 4-triazol-3-yl)ethanes.
The acylhydrazones 3, obtained by the treatment of succinic acid dihydrazide 2 with furfural, nitrofurfuraldehydediacetate and substituted arylfurfurals, on oxidative cyclization with bromine in acetic acid yielded 1,2-bis(1,3,4-oxadiazol-2-yl)ethanes 4 which are further converted into 1,2-bis(4-amino-1,2,4-triazol-3-yl)ethanes 5 with hydrazine hydrate. The newly synthesised compounds are characterised by analytical, IR, NMR and mass spectral data. Most of the newly synthesised compounds have been found to be active against both Gram positive and Gram negative bacteria at less than 6 microg/mL concentration.
Holla
B S
BS
Department of Post Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangothri, India.
Gonsalves
R
R
Shenoy
S
S
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D010069:Oxadiazoles; D014230:Triazoles