title: In vitro activity of A-192411.29, a novel antifungal lipopeptide.
abstract: A-192411.29 is a novel antifungal agent derived from the structural template of the natural product echinocandin. The in vitro activity of A-192411.29 against common pathogenic yeasts was assessed by National Committee for Clinical Laboratory Standards method M27-A. It demonstrated broad-spectrum, fungicidal activity and was active against the most clinically relevant yeasts, such as Candida albicans, Candida tropicalis, and Candida glabrata, as well as less commonly encountered Candida species; in general, its potency on a weight basis was comparable to that of amphotericin B. It maintained potent in vitro activity against Candida strains with reduced susceptibilities to fluconazole and amphotericin B. The in vitro activity of A-192411.29 against Cryptococcus neoformans was comparable to its activity against Candida spp. However, A-192411.29 did not demonstrate complete growth inhibition of Aspergillus fumigatus by the broth microdilution method used. A-192411.29 possesses an antifungal profile comparable to or better than those of fluconazole and amphotericin B against pathogenic yeasts, including strains resistant to fluconazole or amphotericin B, suggesting that it may be a therapeutically useful new antifungal drug.
authors.affiliation: Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537, USA. angela.nilius@abbott.com
authors.forename: A M
authors.initials: AM
authors.lastname: Nilius
authors.forename: P M
authors.initials: PM
authors.lastname: Raney
authors.forename: D M
authors.initials: DM
authors.lastname: Hensey-Rudloff
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: R K
authors.initials: RK
authors.lastname: Flamm
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C407876:A 192411.29; D000935:Antifungal Agents; D010455:Peptides; D010456:Peptides, Cyclic