Anticonvulsant properties of various acetylhydrazones, oxamoylhydrazones and semicarbazones derived from aromatic and unsaturated carbonyl compounds.
Various acetylhydrazones, oxamoylhydrazones and semicarbazones were prepared as candidate anticonvulsants with a view to examining the viability of a putative binding site hypothesis. Atomic charge calculations were undertaken to determine the hydrogen bonding capacities of various molecules. The biological results obtained revealed that in general the acetylhydrazones and semicarbazones afforded good protection against convulsions while the oxamoylhydrazones were significantly less active. These data suggest that terminal electron-donating groups enhanced the hydrogen bonding capabilities and anticonvulsant properties of these molecules.
Dimmock
J R
JR
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. dimmock@skyway.usask.ca
Vashishtha
S C
SC
Stables
J P
JP
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D015195:Drug Design; D004597:Electroshock; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007274:Injections, Intraperitoneal; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012664:Semicarbazones / Q000138:chemical synthesis* / Q000494:pharmacology
D000927:Anticonvulsants; D006835:Hydrazones; D012664:Semicarbazones; D010433:Pentylenetetrazole