[Polymorphism T174M of the angiotensinogen gene in Siberian populations].
The level of T174M polymorphism of the angiotensinogen gene (AGT) was studied for the first time in Siberian populations. The frequency of allele M was found to be 7% in Russians, 6% in Tuvinians, and 4% in Buryats. In the Mongoloid population of Siberia (Tuvinians and Buryats), the genotypic frequencies deviated from Hardy-Weinberg equilibrium (P < 0.05). The studied polymorphism of the AGT gene determined in Siberian populations was compared with that of other ethnic groups in the world population, and genetic distinctions were estimated. Only the Buryat population was found to differ significantly from the French, English, and Chinese in the frequency of allele M. No association between the T174M polymorphism of the AGT gene and pathological pregnancy (gestosis) was revealed in Buryat women.
Kosiankova
T V
TV
Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Eremina
E R
ER
Puzyrev
V P
VP
Saliukov
V B
VB
D000808:Angiotensinogen / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D017931:DNA Primers; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012800:Siberia
D017931:DNA Primers; D000808:Angiotensinogen