title: Lympholeukemia in madai Pagrus major in Japan.
abstract: Lympholeukemia has been occurring to an epizootic extent with mass mortality in 1 and 2 yr old madai (= Japanese red sea bream) Pagrus major in the winter season (October-May) in the western regions of Japan since 1975. Diseased fish displayed severe anemia and markedly increased numbers of neoplastic lymphocytoid and lymphoblastoid cells in the blood. Neoplastic cells originated in the splenic lymphatic cells and systemically caused severe metastatic lesions in the heart, liver, kidney, digestive tracts, gills and the lateral musculature. Electron microscopy revealed adeno-like viral particles (78 to 83 nm in diameter) in the nucleus of lymphoblastoid cells which appeared in the early prevalent stage but no viral particles in the lymphocytoid cells or plasmacytoid cells, which subsequently increased in number. In this paper, we describe light and electron microscopic features of neoplasms and neoplastic cells.
authors.affiliation: Faculty of Bioresources, Mie University, Japan. miyazaki@bio.mie-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Asai
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Miyata
mesh_terms: D000818:Animals; D005393:Fish Diseases / Q000209:etiology* / Q000473:pathology; D007564:Japan; D007945:Leukemia, Lymphoid / Q000473:pathology / Q000662:veterinary*; D008854:Microscopy, Electron; D010473:Perciformes; D014771:Virion / Q000648:ultrastructure