title: Physical exercise, aortic blood pressure, and aortic wall elasticity and composition in rats.
abstract: With a training schedule (8 weeks' treadmill running at 30 m/min up a 10% incline 5 d/wk for 90 min/day), we investigated whether exercise modifies aortic wall dimensions, composition (calcium and elastin content), or stiffness in normotensive 6-month-old male Wistar WAG/Rij rats. Maximal oxygen uptake was measured in half of the rats (n=10 per group). Wall stiffness was evaluated in the other half (9 trained and 10 untrained) on the basis of changes in thoracoabdominal pressure pulse wave velocity and differences in amplitude between the peripheral and central aortic pressure signals. Experiments were performed in nonanesthetized, unrestrained rats and then after pithing. The impact of exercise on the oxidative capacity of the plantaris muscles was evaluated with the measurement of citrate synthase activity. Training increased maximal oxygen uptake by 34% and citrate synthase activity by 40%. Mean peripheral aortic pressure increased by 6% and 19% in trained rats, under awake and pithed conditions, whereas mean central aortic pressure increased by 16%, after pithing only. All indexes of aortic stiffness were similar in trained and control rats, as were aortic wall dimensions, composition, cardiac mass, and heart rate. In conclusion, physical exercise in young rats appears to have no effect on aortic stiffness.
authors.affiliation: Laboratoire de Pharmacologie Cardio-vasculaire, Faculté de Pharmacie de l'Université Henri Poincaré, Nancy I, France.
authors.forename: N
authors.initials: N
authors.lastname: Niederhoffer
authors.forename: P
authors.initials: P
authors.lastname: Kieffer
authors.forename: D
authors.initials: D
authors.lastname: Desplanches
authors.forename: I
authors.initials: I
authors.lastname: Lartaud-Idjouadiene
authors.forename: M H
authors.initials: MH
authors.lastname: Sornay
authors.forename: J
authors.initials: J
authors.lastname: Atkinson
mesh_terms: D000818:Animals; D001011:Aorta / Q000166:cytology / Q000502:physiology*; D001794:Blood Pressure; D002118:Calcium / Q000502:physiology; D004548:Elasticity; D004549:Elastin / Q000502:physiology; D008297:Male; D010101:Oxygen Consumption; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004549:Elastin; D002118:Calcium