Humoral and cell mediated immune responses in patient with tuberculous meningitis.
A study was carried out to find out the humoral and cell mediated immunity levels in patients with TBM and healthy controls. For humoral immunity, the amounts of immunoglobulins--IgG, IgM and IgA were quantitated by SRID method. For cell mediated immunity, percentages of total T cells, Th cells and Ts cells and the ratio of Th:Ts cells was studied. Hypergammaglobulinemia of all three immunoglobulins was observed together with a decrease in the total T cells and Th cells, and a lower Th:Ts cell ratio indicating a deficiency or a defect in the immune system of patients infected with TBM.
Kamat
H A
HA
Department of Microbiology, Topiwala National Medical Medical College, Mumbai. hakamat@xtra.co.nz
Williamson
M
M
Koppikar
G V
GV
D000917:Antibody Formation / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000134:cerebrospinal fluid; D007194:India; D008297:Male; D012680:Sensitivity and Specificity; D015996:Survival Rate; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid / Q000276:immunology* / Q000401:mortality
D007074:Immunoglobulin G