title: Seroprevalence of hepatitis B, hepatitis C, CMV and HIV in multiply transfused thalassemia patients: results from a thalassemia day care center in Malaysia.
abstract: Regular blood transfusions for patients with thalassemia have improved their overall survival although these transfusions carry a definite risk of the transmission of certain viruses. Infection with hepatitis B virus (HBV), hepatitis C virus (HCV), cytomegalovirus (CMV) and human immunodeficiency virus (HIV) leads to complications which contribute to the morbidity and mortality of patients with thalassemia. We analyzed the blood samples taken from 85 transfusion dependent thalassemics receiving treatment at the day care center in Hospital Universiti Kebangsaan Malaysia and found that the seroprevalence rates for HBV, HCV and CMV were 2.4%, 22.4% and 91.8% respectively. None of the patients tested positive for HIV. Those positive for HBV and HCV will require further tests and treatment if chronic hepatitis is confirmed.
authors.affiliation: Department of Pediatrics, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur.
authors.forename: R
authors.initials: R
authors.lastname: Jamal
authors.forename: G
authors.initials: G
authors.lastname: Fadzillah
authors.forename: S Z
authors.initials: SZ
authors.lastname: Zulkifli
authors.forename: M
authors.initials: M
authors.lastname: Yasmin
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002656:Child Day Care Centers / Q000706:statistics & numerical data; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000209:etiology; D006509:Hepatitis B / Q000453:epidemiology / Q000209:etiology; D006526:Hepatitis C / Q000453:epidemiology / Q000209:etiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007223:Infant; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D016036:Seroepidemiologic Studies; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000628:therapy / Q000821:virology*