title: Practical utility of the revised European-American classification of lymphoid neoplasms for Japanese non-Hodgkin's lymphomas.
abstract: A clinicopathological study of 515 non-Hodgkin's lymphoma (NHL) cases was performed using the revised European-American classification of lymphoid neoplasms (REAL classification) in an HTLV1-nonendemic area of Japan. The following characteristics were revealed: 1) frequency of extranodal lymphomas was high (59%) with 79% B-cell lymphomas in this series, while the overall ratio of B:T/NK lineage was 3.7:1; 2) the most common type was the diffuse large B-cell lymphoma (46%), follicle center lymphomas occurred at an incidence lower (15%) than that in European and American populations, and marginal zone B-cell lymphomas accounted for as much as 12%; 3) peripheral T-cell lymphomas were common (19%), with the unspecified type predominant (11%), while adult T-cell lymphomas were present at a level equivalent to that among European and American patients (1%). Clear segregation of survival curves was rated according to cell lineage and B-cell lymphomas had a better prognosis than T / NK-cell lymphomas. Furthermore, new subtypes in the REAL classification, such as marginal zone B-cell and mantle cell lymphomas, exhibited distinct curves. Taken altogether, the REAL classification demonstrated advantages for assessment of Japanese NHL cases.
authors.affiliation: Department of Pathology, Komuro, Ina-machi, Saitama 362-0806, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Izumo
authors.forename: N
authors.initials: N
authors.lastname: Maseki
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: E
authors.initials: E
authors.lastname: Tsuchiya
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000951:Antigens, Neoplasm / Q000276:immunology; D002675:Child, Preschool; D006801:Humans; D016130:Immunophenotyping / Q000379:methods; D007694:Killer Cells, Natural; D016393:Lymphoma, B-Cell / Q000145:classification* / Q000401:mortality / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000145:classification* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D000951:Antigens, Neoplasm