Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.
We have investigated the roles of gamma interferon (IFN-gamma) and interleukin-4 (IL-4) in host defense against Brugia malayi. Our data suggest that the lack of either IFN-gamma or IL-4 prolongs the time required to achieve sterile immunity, suggesting that both canonical type 1 and type 2 responses are involved in the clearance of infection.
Babu
S
S
Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06030-3105, USA.
Ganley
L M
LM
Klei
T R
TR
Shultz
L D
LD
Rajan
T V
TV
D000818:Animals; D017178:Brugia malayi / Q000276:immunology*; D004195:Disease Models, Animal; D004605:Elephantiasis, Filarial / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016513:Mice, SCID
D015847:Interleukin-4; D007371:Interferon-gamma