Effect of ethanol/arrack on the lipid metabolism of mammary gland during pregnancy and lactation in rats.
Female rats were exposed to arrack (12.0 ml/kg body weight/day) and ethanol (4.0 g/kg body weight/day) before conception and throughout gestation and lactation. On 19th day of gestation and 21st day of lactation there was increase in the cholesterol phospholipids, triglycerides and free fatty acids in the mammary gland of rats administered arrack/ethanol in comparison with the controls. The lipoprotein lipase activity showed significant increase in the treated groups, in which the activity decreased on 21st day in comparison with 19th day. The absolute and relative weight of mammary gland also showed a significant decrease in ethanol/arrack treated group. The biochemical alterations produced in the mammary gland by arrack and its equivalent alcohol were different showing that non-alcoholic portion of arrack interferes with the toxicity induced by alcohol. Arrack was found to be a potent hyperlipidemic agent than ethanol.
Sreeranjitkumar
C V
CV
Department of Biochemistry, University of Kerala, Trivandrum.
Lal
J J
JJ
Suresh
M V
MV
Indira
M
M
Vijayammal
P L
PL
D000434:Alcoholic Beverages / Q000633:toxicity*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D007774:Lactation / Q000187:drug effects / Q000378:metabolism; D050356:Lipid Metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D010743:Phospholipids; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol