title: Plasma clearance of 99Tcm-MAG3: accuracy of five single-sample methods.
abstract: The aim of this study was to compare the accuracy of five single-injection, single-sample methods for the assessment of plasma clearance of 99Tcm-MAG3 in adults. In 51 patients, a reference plasma clearance was determined on the basis of 16 blood samples. It ranged from 13 to 313 ml.min-1. In patients with a plasma clearance less than 75 ml.min-1, there was a large difference between the clearance obtained by a single-sample method and the reference method. Thus single-sample methods should not be used with these patients. In patients with a plasma clearance higher than 75 ml.min-1, the relative difference was (mean +/- s): 6.07 +/- 9.96% (Russell et al., 1989), 14.22 +/- 8.08% (Müller-Suur et al., 1991), 7.29 +/- 6.21% (Bubeck et al., 1992), 6.64 +/- 7.71% (Russell et al., 1996) and 17.39 +/- 7.39% (Piera et al., 1997). Reference clearance was overestimated by all five single-sample methods, especially by the methods of Müller-Suur et al. and Piera et al. The smallest standard deviation was obtained using the method of Bubeck et al. This method is recommended for use in patients with a plasma clearance greater than 75 ml.min-1.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Aarhus University Hospital, Section Skejby Hospital, Denmark. mr@nucmed.auh.dk
authors.forename: M
authors.initials: M
authors.lastname: Rehling
authors.forename: L E
authors.initials: LE
authors.lastname: Nielsen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000097:blood / Q000493:pharmacokinetics; D012016:Reference Values; D017263:Technetium Tc 99m Mertiatide / Q000097:blood* / Q000493:pharmacokinetics; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; D017263:Technetium Tc 99m Mertiatide