[The effects of the intraventricular administration of captopril on water and ion metabolism in the rst].
The effects of the conversion enzyme on the hydroelectrolytic balance in adult rats, maintained in standard lab conditions have been followed. The administration protocol for the conversion inhibitor (captopril) produced a blocking of the transformation of angiotensin I in angiotensin II only at the level of the cerebral structures, during the whole period of the treatment (40 micrograms/kg x 3/24 hours). Following the intracerebroventricular (ICV) administration of captopril, the fluid ingestion decreased diuresis and urinary elimination of Na+ and Ca++ increased. The results plead for the existence of a cerebral renin-angiotensin system, which intervenes in the control of the hydroelectrolyte metabolism.
Slătineanu
S M
SM
Disciplina de Fiziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Haulică
I
I
Costuleanu
A
A
Mândreci
I
I
Petrescu
G
G
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000008:administration & dosage* / Q000494:pharmacology; D002395:Catecholamines / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014867:Water / Q000378:metabolism*
D000806:Angiotensin-Converting Enzyme Inhibitors; D002395:Catecholamines; D004573:Electrolytes; D014867:Water; D002216:Captopril