title: New bisindole alkaloids of the topsentin and hamacanthin classes from the Mediterranean marine sponge Rhaphisia lacazei.
abstract: Chemical investigation of the Et(2)O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1-13). Compounds (1-6) belong to the class of topsentins and have already been described. Compounds 7-13 are new products, closely related to the class of hamacanthins. The major compounds 1-3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human bronchopulmonary cancer cells (NSCLC-N6) with an IC(50) of 12 and 6.3 microg/mL, respectively.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo, Fisciano (SA) 84084, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Casapullo
authors.forename: G
authors.initials: G
authors.lastname: Bifulco
authors.forename: I
authors.initials: I
authors.lastname: Bruno
authors.forename: R
authors.initials: R
authors.lastname: Riccio
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D007093:Imidazoles / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010879:Piperazines / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014020:Tissue Extracts / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D007211:Indoles; D010879:Piperazines; D014020:Tissue Extracts; C070184:topsentin