title: HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks.
abstract: The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.
authors.affiliation: National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
authors.forename: A
authors.initials: A
authors.lastname: Papa
authors.forename: E
authors.initials: E
authors.lastname: Papadimitriou
authors.forename: G
authors.initials: G
authors.lastname: Adwan
authors.forename: J P
authors.initials: JP
authors.lastname: Clewley
authors.forename: N
authors.initials: N
authors.lastname: Malissiovas
authors.forename: I
authors.initials: I
authors.lastname: Ntoutsos
authors.forename: S
authors.initials: S
authors.lastname: Alexiou
authors.forename: A
authors.initials: A
authors.lastname: Antoniadis
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006115:Greece; D015658:HIV Infections / Q000235:genetics*; D018023:HIV Seronegativity / Q000235:genetics; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics*; D015728:Receptors, HIV / Q000235:genetics*
chemical_list: C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D015728:Receptors, HIV