Smoking and the molecular epidemiology of lung cancer.
Lung carcinogenesis in humans requires exposure to environmental agents, including the inhalation of tobacco smoke, radioactive compounds, asbestos, heavy metals, and petrochemicals. Tobacco smoking is the risk factor with the highest attributable lung cancer risk worldwide. This article discusses occupational carcinogen exposure and exposure from tobacco use, and the lung-cancer risk associated with these types of exposure.
Christiani
D C
DC
Department of Occupational Medicine and Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. dchris@hohp.harvard.edu
D014408:Biomarkers, Tumor; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004273:DNA, Neoplasm / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism; D017720:Molecular Epidemiology; D011110:Polymorphism, Genetic; D012907:Smoking / Q000453:epidemiology*
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D003577:Cytochrome P-450 Enzyme System