title: Haptoglobin 1F allele frequency is high among indigenous populations in the state of Durango, Mexico.
abstract: We studied haptoglobin polymorphism in Mexican populations with high Indian ancestry living in isolated and urban areas in the state of Durango. Analysis with respect to the HP*1F and HP*1S allelic subtypes by isoelectric focusing showed unusually high HP*1F allele frequencies among urban (0.370) and isolated Mexican Indians (0.383). Comparison with other population studies demonstrated a geographical cline of the HP*1F allele increasing in the same direction of the HP*1 allele, while HP*1S frequency does not show racial differences.
authors.affiliation: Department of Clinical Chemistry, University Hospital, Gent, Belgium. joris.delanghe@rug.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Delanghe
authors.forename: M
authors.initials: M
authors.lastname: Langlois
authors.forename: C
authors.initials: C
authors.lastname: Alvarado Esquivel
authors.forename: H
authors.initials: H
authors.lastname: De Haene
authors.forename: M
authors.initials: M
authors.lastname: De Buyzere
mesh_terms: D000483:Alleles; D004641:Emigration and Immigration; D005787:Gene Frequency; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007197:Indians, Central American / Q000235:genetics*; D008800:Mexico; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D006242:Haptoglobins