Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.
When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p <0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p <0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.
O'Doherty
J
J
Department of Experimental Psychology, University of Oxford.
Rolls
E T
ET
Francis
S
S
Bowtell
R
R
McGlone
F
F
Kobal
G
G
Renner
B
B
Ahne
G
G
D004435:Eating / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D009833:Olfactory Pathways / Q000033:anatomy & histology* / Q000502:physiology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D018035:Receptors, Odorant / Q000502:physiology; D012201:Reward; D012527:Satiation / Q000502:physiology*; D012903:Smell / Q000502:physiology*
D018035:Receptors, Odorant