[Influence of berotec inhalations on pulmonary gas exchange in patients with bronchial asthma].
OBJECTIVE
To determine mechanisms inducing changes in lung gas exchange after berotec inhalation in patients with bronchial asthma (BA).


METHODS
A study was made of external respiration function including estimation of lung transfer factor (TLCO sbh.) and its components--transfer coefficient (KCO), membrane diffusion capacity (DM), pulmonary capillary blood volume (Vc)--by the single breath holding method on CO in 14 healthy persons and 39 patients with BA before and after berotec inhalation. The data were obtained in the absolute values and their changes after berotec inhalation were measured in percent to initial ones.


RESULTS
In healthy subjects we did not observe changes of TLCO sbh. and its components after berotec inhalation, only an insignificant decrease of VA eff. was registered (p < 0.01). After berotec inhalation a considerable improvement in Sgaw, FEV1, RPV and a decrease of TLCO sbh., KCO were observed. Changes in TLCO sbh. were caused by a decrease in DM without changes in VA eff. in BA patients with initial normal values of KCO. In patients with smaller initial values of KCO moderate improvement of bronchial permeability without changes in KCO, PaO2 were observed. These changes occurred due to a decrease of VA eff.


CONCLUSIONS
Changes of the transfer factor and its components in patients with BA reflect two types of adaptation reactions in response to berotec inhalation and their role in mechanisms of compensation of gas exchange in the lungs.
Sinitsina
T M
TM
Klimenkova
S F
SF
Genkin
A A
AA
D000280:Administration, Inhalation; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001784:Blood Gas Analysis; D005280:Fenoterol / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D011653:Pulmonary Diffusing Capacity / Q000187:drug effects*; D016896:Treatment Outcome
D000318:Adrenergic beta-Agonists; D005280:Fenoterol