L-myc restriction fragment length polymorphism in Japanese patients with esophageal cancer.
L-myc polymorphism is a representative genetic trait related to an individual's susceptibility to several cancers. However, there have been no reports concerning the association between esophageal cancer and L-myc polymorphism. To analyze the distribution of polymorphism in Japanese patients with esophageal cancer, a molecular genotyping method using a polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) was used. Based on an analysis of 65 Japanese patients with esophageal cancer and 107 healthy control subjects, a significant difference was observed in either the distribution of genotypes (P=0.012) or of allele frequencies between the two groups (P=0.004). The relative risk of esophageal cancer for genotypes including the shorter allele was 2.9 compared to the longer allele homozygote. Furthermore, the patients with S-allele had a tendency for poor prognosis among those with three genotypes. A significant difference between the distribution of genotypes and the incidence of lymph node metastasis was found based on the clinicopathological features of the cancers. These results suggest that L-myc polymorphism may be implicated as a genetic trait affecting an individual's susceptibility to esophageal cancer, at least among Japanese patients.
Shibuta
K
K
Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu.
Inoue
H
H
Sato
K
K
Matsuyama
A
A
Ueo
H
H
Tanaka
Y
Y
Mafune
K
K
Barnard
G F
GF
Mori
M
M
D004938:Esophageal Neoplasms / Q000235:genetics* / Q000401:mortality; D016259:Genes, myc; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D015996:Survival Rate