Locomotor behavioral effects of prenatal and postnatal nicotine exposure in rat offspring.
The purpose of this study was to determine if prenatal/postnatal nicotine exposure results in hyperactive offspring. Rat offspring were exposed to nicotine, through implantation of osmotic minipumps in dams, at levels of 0.75, 1.5 and 3.0 mg/kg/day, for 19 days prenatally and 16 days postnatally. Offspring were measured for gestation length, body weight, litter size, sex difference and locomotor activity. No significant effects were shown for gestation length, litter size or male to female pup ratio. However, higher percentage of pup deaths resulted from nicotine-exposed dams than from control dams. Significantly less litter body weight was shown in nicotine-exposed offspring on postnatal day 1 when compared to controls. However, these offspring surpassed the control groups in litter body weight on postnatal day 14 and 21. Hyperactivity was shown in offspring exposed to prenatal/postnatal nicotine at levels of 0.75 and 3.0 mg/kg/day on postnatal day 14, but not on postnatal day 21 or at the 1.5 mg/kg/day condition. Results are consistent with the hypothesis that rat offspring are susceptible to the neurochemical and neurobehavioral effects of prenatal/postnatal nicotine exposure.
Newman
M B
MB
Department of Psychology, University of South Florida, College of Arts and Science, College of Medicine, Tampa, USA.
Shytle
R D
RD
Sanberg
P R
PR
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001724:Birth Weight / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004343:Drug Implants; D005260:Female; D008098:Litter Size / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics
D004343:Drug Implants; D018722:Nicotinic Agonists; D009538:Nicotine