title: Pulmonary alveolar proteinosis: a complication in patients with hematologic malignancy.
abstract: We present the case of a patient with acute myeloid leukemia and secondary Pulmonary Alveolar Proteinosis (PAP), which is an underestimated cause of a persistent pulmonary infiltrate in patients with hematologic malignancies often accompanied by neutropenia due to therapy. Diagnosis is established by performing Periodic Acid-Schiff reaction (PAS) stains and transmission electron microscopy (EM) on bronchoalveolar lavage (BAL) fluid. We wish to stress the importance of the early recognition of PAP, which is potentially reversible, and routinely performing PAS staining on BAL fluid in patients with a hematologic disease especially myeloid disorders and a persistent lung infiltrate.
authors.affiliation: Department of Internal Medicine, Reinier de Graaf Gasthuis, R. de Graafweg 3, 2625 AD, Delft, The Netherlands.
authors.forename: C A
authors.initials: CA
authors.lastname: Birsak
authors.forename: R N
authors.initials: RN
authors.lastname: van Rossem
authors.forename: J M
authors.initials: JM
authors.lastname: Nijhuis-Heddes
authors.forename: E
authors.initials: E
authors.lastname: Maartense
mesh_terms: D001992:Bronchoalveolar Lavage Fluid; D017809:Fatal Outcome; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D010503:Periodic Acid-Schiff Reaction; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis* / Q000209:etiology