title: HLA-DR expression of synovium and correlation with clinical features of patients with rheumatoid arthritis.
abstract: To investigate whether the expression of human leukocyte antigen-DR (HLA-DR) in synovial tissues obtained at synovectomy contributes to the clinical features of patients with rheumatoid arthritis (RA), immunohistochemical analysis was performed to determine the intensity and pattern of HLA-DR expression in synovial tissue from 96 patients with RA. The clinical features before and 1 year after the synovectomy were investigated. At the time of the surgery, duration of morning stiffness was associated with the degree of HLA-DR expression in synovial lining layer, and this synovial lining expression of HLA-DR was more frequently observed in elbow and wrist joints than in knee joint. In patients who underwent knee synovectomy, erythrocyte sedimentation rate and C-reactive protein level one year after the surgery were significantly higher in the patients with intense expression of HLA-DR in the synovial lining. Our findings showed that the expression of HLA-DR in the synovial lining contributes to several clinical features, and the expression in large joint such as knee may related with disease course of patients with RA.
authors.affiliation: Department of Orthopedic Surgery, Akita University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Sageshima
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D004551:Elbow Joint / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006684:HLA-DR Antigens / Q000096:biosynthesis*; D006801:Humans; D007124:Immunoenzyme Techniques; D007719:Knee Joint / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D000074402:Synovectomy; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology; D014955:Wrist Joint / Q000378:metabolism / Q000473:pathology / Q000601:surgery
chemical_list: D006684:HLA-DR Antigens; D002097:C-Reactive Protein