[Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism].
The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.
Krupitskiĭ
E M
EM
Regional Scientific Center for Research in Addictions and Psychopharmacology, Pavlov St. Petersburg State Medical University. kru@lond.spb.su
Karandashova
G F
GF
Vostrikov
V V
VV
Lavrova
N M
NM
Grinenko
N I
NI
Slavina
T Iu
TIu
Grinenko
A Ia
AIa
D000437:Alcoholism / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*
D000431:Ethanol; D008995:Monoamine Oxidase