title: [Effectiveness of treatment with metformin in patients with type 2 diabetes mellitus poorly controlled with insulin treatment].
abstract: Combined treatment with insulin plus metformin could be a good alternative to improve the glycemic control in patients with type 2 diabetes mellitus poorly controlled with insulin therapy. We retrospectively studied 21 obese insulin-treated type 2 diabetic patients with deficient metabolic control (HbA1c 9.2 +/- 1.2%) who were treated with metformin for a minimum of 8 months. After 4 months of treatment, a significant decrease in the percentage of HbA1c was observed (delta HbA1c -1.07 +/- 1.12%; p < 0.01), with maintained values since then. Non changes in body weight or insulin requirement were noted. Our results suggest that the addition of metformin to insulin treatment is a safe and effective strategy for the improvement of glycemic control among obese type 2 diabetic patients.
authors.affiliation: Sección de Endocrinología y Nutrición, Hospital Universitario Insular, Las Palmas de Gran Canaria.
authors.forename: M
authors.initials: M
authors.lastname: Boronat Cortés
authors.forename: D
authors.initials: D
authors.lastname: Marrero Arencibia
authors.forename: F
authors.initials: F
authors.lastname: La Roche Brier
authors.forename: A
authors.initials: A
authors.lastname: Ojeda Pino
authors.forename: A
authors.initials: A
authors.lastname: Carrillo Domínguez
authors.forename: F J
authors.initials: FJ
authors.lastname: Nóvoa Mogollón
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin