Improvement in circulating superoxide dismutase levels: role of nonsteroidal anti-inflammatory drugs in rheumatoid arthritis.
Superoxide anion radical plays a significant role in inflammation, like rheumatoid arthritis. Superoxide dismutase enzyme known to dismutate superoxide anion radical does not play any significant role in this multisystem disease. This paper reports that very low levels of circulating superoxide dismutase levels are observed in patients with rheumatoid arthritis and these levels significantly improve with NSAID therapy. The possible mechanism of the action is discussed.
Nivsarkar
M
M
B. V. Patel Pharmaceutical Education and Research Development Centre, Thaltej-Gandhinagar Highway, Gujarat, Thaltej, Ahmedabad-380, 054, India.
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D013482:Superoxide Dismutase / Q000097:blood*; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013482:Superoxide Dismutase