title: [Drug hypersensitivity syndrome to valproic acid].
abstract: BACKGROUND
  Drug-induced hypersensitivity syndrome is an uncommon but potentially life-threatening idiosyncratic drug reaction. It is usually due to aromatic anti-convulsants. We report the second case induced by sodium valproate, a non-aromatic anticonvulsant.
  
  
  METHODS
  A 28-year-old woman was treated with sodium valproate for 5 weeks. She suddenly developed a generalized maculo-papulous eruption with fever, node enlargement, hypereosinophilia and altered liver function.
  
  
  CONCLUSIONS
  Drug-induced hypersensitivity is rarely induced by valproic acid. The time-course and positive patch tests using the diluted drug establish the diagnosis.
authors.affiliation: Service de Dermatologie, CHU Rangueil, Toulouse.
authors.forename: N
authors.initials: N
authors.lastname: Picart
authors.forename: B
authors.initials: B
authors.lastname: Périole
authors.forename: J
authors.initials: J
authors.lastname: Mazereeuw
authors.forename: J L
authors.initials: JL
authors.lastname: Bonafé
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D010328:Patch Tests; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid