[Glutathione peroxidase, an oxidative stress biomarker, in the menstrual cycle].
The oxygen, through his toxic effects, has determined the human organism to perfectionate multiple and efficient protection systems, especially the GSH-Px.


OBJECTIVE
To study the activity of GSHPx activity in the 0, 14 and 28 days of the menstrual cycle in a group of women with psychiatric disorders.


METHODS
The activity of GSH-Px was investigated in 24 women inpatients from the Psychiatric Department of Murgeni Hospital Vaslui. The GSH-Px level was determined in human serum using Fukuzawa method, modified in the Biochemistry Lab of the "Al. I. Cuza" University, Iaşi.


RESULTS
It has been no correlation between the type of psychiatric disorders and the level of GSHPx. This activity of GSHpx is in direct relationship with the concentration of sexual hormones, showing an hormone dependent enzymatic induction. A growth of the GSHPx activity from the day 0 to the 28th day of the menstrual cycle followed by a sudden decrease at menstruation time have been observed in all age groups. This fact demonstrated the existence of an enzymatic cycle.
Darie
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Secţia de Genetică Moleculară, Facultatea de Biologie, Universitatea Al.I. Cuza, Iaşi.
Jerca
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Artenie
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Margina
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D000328:Adult; D000375:Aging / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood*; D001523:Mental Disorders / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D013997:Time Factors
D015415:Biomarkers; D005979:Glutathione Peroxidase