Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure.
In vitro susceptibility testing and genotyping were done on urogenital isolates of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical treatment failure with azithromycin and one of whom was the wife of a patient. All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin, and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due to relapsing infection with the same resistant isolate was documented on the basis of identical genotypes of both organisms. This first report of clinically significant multidrug-resistant C. trachomatis causing relapsing or persistent infection may portend an emerging problem to clinicians and public health officials.
Somani
J
J
Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia 30333, USA.
Bhullar
V B
VB
Workowski
K A
KA
Farshy
C E
CE
Black
C M
CM
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D017963:Azithromycin / Q000627:therapeutic use; D002690:Chlamydia Infections / Q000188:drug therapy*; D002692:Chlamydia trachomatis / Q000145:classification / Q000187:drug effects / Q000235:genetics*; D018562:Disease Transmission, Infectious; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D014526:Urethritis / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D017963:Azithromycin; D015242:Ofloxacin