title: Evaluation of pressure/volume loops based on intratracheal pressure measurements during dynamic conditions.
abstract: BACKGROUND
  The aim of this study was to evaluate and compare information about lung mechanics obtained by dynamic pressure/volume loops based on Y-piece and intratracheal airway pressure.
  
  
  METHODS
  Airway pressure was measured simultaneously at the Y-piece and trachea. Flow/tidal volume was measured by sidestream spirometry at the Y-piece. The effect of an intraluminal catheter in the tube was evaluated in a lung model. Ten adults with acute lung injury and mechanical ventilation were studied. Measurements were performed during volume-(VC) and pressure-controlled (PC) ventilation at different ventilator settings.
  
  
  RESULTS
  Lung model: There was a statistically significant difference (P<0.001) between trachea and Y-piece pressure/volume loop areas during both VC and PC ventilation. The ratio trachea area/Y-piece area decreased with increased endotracheal tube resistance (r=0.96).
  
  
  METHODS
  The difference between trachea and Y-piece P/V-loops was statistically significant at all 21 ventilatory settings (P<0.05-0.001). The tracheal loop revealed clearly intrinsic PEEP and lowered compliance during overinflation, which was difficult or impossible to see in the Y-piece pressure/volume loop.
  
  
  CONCLUSIONS
  By measuring airway pressure at the trachea the effect of endotracheal tube resistance during inspiration is excluded while it is included during expiration, yielding correct end-points of inspiration and expiration. This makes it possible to calculate accurately total compliance of the respiratory system during dynamic conditions. By monitoring of airway pressure in the trachea, respiratory mechanics can be assessed more accurately and ventilatory settings adjusted to attenuate ventilator induced lung injury.
authors.affiliation: Department of Anaesthesia and Intensive Care, Sahlgrenska University Hospital, Göteborg, Sweden. sigge.karason@molndal.mail.telia.com
authors.forename: S
authors.initials: S
authors.lastname: Kárason
authors.forename: S
authors.initials: S
authors.lastname: Søndergaard
authors.forename: S
authors.initials: S
authors.lastname: Lundin
authors.forename: J
authors.initials: J
authors.lastname: Wiklund
authors.forename: O
authors.initials: O
authors.lastname: Stenqvist
mesh_terms: D000368:Aged; D000403:Airway Resistance; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D008961:Models, Structural; D011175:Positive-Pressure Respiration; D018467:Positive-Pressure Respiration, Intrinsic; D011312:Pressure; D012123:Pulmonary Ventilation; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy; D015656:Respiratory Mechanics; D013147:Spirometry; D013990:Tidal Volume; D014132:Trachea / Q000503:physiopathology