Site-specific serine incorporation by Lif and Epr into positions 3 and 5 of the Staphylococcal peptidoglycan interpeptide bridge.
The FemAB-like factors Lif and Epr confer resistance to glycylglycine endopeptidases lysostaphin and Ale-1, respectively, by incorporating serine residues into the staphylococcal peptidoglycan interpeptide bridges specifically at positions 3 and 5. This required the presence of FemA and/or FemB, in contrast to earlier postulations.
Ehlert
K
K
Bayer AG, PH Research Antiinfectives I, D-42096 Wuppertal, Germany.
Tschierske
M
M
Mori
C
C
Schröder
W
W
Berger-Bächi
B
B
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D016297:Mutagenesis, Site-Directed; D010455:Peptides / Q000378:metabolism; D010457:Peptidoglycan / Q000378:metabolism*; D012694:Serine / Q000235:genetics / Q000378:metabolism*; D013210:Staphylococcus / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; C107107:Epr protein, Staphylococcus capitis; C096686:FemA protein, Bacteria; C102928:FemB protein, Staphylococcus epidermidis; D010455:Peptides; D010457:Peptidoglycan; D012694:Serine