Acellular pertussis vaccines.
Although whole-cell pertussis vaccines have been highly effective in preventing whooping cough, their common and burdensome adverse reactions have spurred the development of safer alternatives. Seven acellular vaccines are licensed in one or more countries; four have been licensed thus far in the United States, and more may follow. Although the licensed acellular pertussis vaccines differ in their immunogenicity, adverse reactions, and efficacy, all are effective and, compared with whole-cell vaccine, are associated with markedly fewer and milder adverse reactions.
Decker
M D
MD
Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. michael.decker@mcmail.vanderbilt.edu
Edwards
K M
KM
D000907:Antibodies, Bacterial; D002648:Child; D002986:Clinical Trials as Topic; D000075202:Contraindications; D003353:Corynebacterium diphtheriae / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology; D006801:Humans; D010567:Pertussis Vaccine / Q000009:adverse effects
D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D010567:Pertussis Vaccine