title: Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.
abstract: A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.
authors.affiliation: Infectious Diseases Research, Abbott Laboratories, Abbott Park, IL 60064-3537, USA. rick.f.clark@abbott.com
authors.forename: R F
authors.initials: RF
authors.lastname: Clark
authors.forename: Z
authors.initials: Z
authors.lastname: Ma
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Griesgraber
authors.forename: M
authors.initials: M
authors.lastname: Tufano
authors.forename: H
authors.initials: H
authors.lastname: Yong
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: A M
authors.initials: AM
authors.lastname: Nilius
authors.forename: D T
authors.initials: DT
authors.lastname: Chu
authors.forename: Y S
authors.initials: YS
authors.lastname: Or
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D004917:Erythromycin