Antiproliferative triterpene saponins from Trevesia palmata.
During the course of a study of plants of the family Araliaceae, antiproliferative activity was demonstrated by the crude saponin fraction of Trevesia palmata. After chromatographic purification, six new bisdesmosidic saponins (1-6), along with two known triterpenoid saponins, (7 and 8), were isolated. The structures of 1-6 were determined by (1)H-(1)H correlation spectroscopy (COSY-DQF, 1D TOCSY, 2D HOHAHA, 1D ROESY) and (1)H-(13)C (HSQC, HMBC) spectroscopy. The antiproliferative activity of compounds 1-8 and of their prosapogenins (2a-7a) prepared by alkaline hydrolysis, was evaluated using three continuous culture cell lines.
De Tommasi
N
N
Dipartimento di Scienze Farmaceutiche, Via Ponte Don Melillo, Invariante 11C, Fisciano, Salerno, Italy. detommasi@unisa.it
Autore
G
G
Bellino
A
A
Pinto
A
A
Pizza
C
C
Sorrentino
R
R
Venturella
P
P
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes / Q000737:chemistry*
D012503:Saponins; D014315:Triterpenes