Spontaneous micronuclei in peripheral blood erythrocytes from 54 animal species (mammals, reptiles and birds): part two.
The normal numbers of micronucleated erythrocytes (MNE) observed in peripheral blood samples differ among species. This depends on the effectiveness of the spleen (or the rest of the reticuloendothelial system) to withdraw them from circulation. In our previous report, we assessed the number of MNE in the peripheral blood of 35 mammalian species. Here we show the results observed in 54 species including mammals, reptiles and birds. We obtained 212 peripheral blood samples from different species. In 14 species, only one individual was studied. Slides were stained with acridine orange. The total number of MNE (normo and polychromatic) in 10,000 erythrocytes per animal are shown. The species that display the higher MNE were: ocelote, lynx, owl, gray squirrel, hedgehog, lion, orange fronted parakeet and common barn owl. For this reason, these species could be tested as monitors for genotoxic events. Another interesting observation was that in the gray squirrel, we found the highest values of MNE in the smaller (younger) animals when compared with the larger (older) of the same species.
Zúñiga-González
G
G
Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, I.M.S.S., Sierra Mojada #800, Colonia Independencia C.P. 44340, Guadalajara, Mexico. mutagenesis96@hotmail.com
Torres-Bugarín
O
O
Luna-Aguirre
J
J
González-Rodríguez
A
A
Zamora-Perez
A
A
Gómez-Meda
B C
BC
Ventura-Aguilar
A J
AJ
Ramos-Ibarra
M L
ML
Ramos-Mora
A
A
Ortíz
G G
GG
Gallegos-Arreola
M P
MP
D000367:Age Factors; D000375:Aging; D000818:Animals; D001717:Birds; D004785:Environmental Pollutants / Q000633:toxicity; D004912:Erythrocytes / Q000473:pathology* / Q000648:ultrastructure; D008322:Mammals; D048629:Micronuclei, Chromosome-Defective / Q000473:pathology*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity; D012016:Reference Values; D012104:Reptiles; D013045:Species Specificity
D004785:Environmental Pollutants; D009153:Mutagens