title: Mesenteric vasoconstriction in response to hemorrhagic shock.
abstract: Previous studies indicate that cardiogenic shock (tamponade) in swine produces selective mesenteric ischemia due to disproportionate mesenteric vasospasm mediated primarily by the renin-angiotensin axis. Here, we characterized the systemic and mesenteric hemodynamic responses to hypovolemic shock to better understand the neurohumoral mechanisms controlling this response. Varying degrees of hypovolemic shock were produced by graded levels of hemorrhage, from 12.5 to 50% of the calculated blood volume. Systemic and mesenteric pressures and blood flows were measured, and corresponding vascular resistances were calculated. The hemodynamic responses of the mesenteric vascular bed were compared with those of the systemic (nonmesenteric) vasculature. These experiments were then repeated after confirmed blockade either of the alpha-adrenergic nervous system (phenoxybenzamine), of vasopressin (Manning compound), or of the renin-angiotensin axis (enalapril). Graded levels of hemorrhage produced corresponding graded, reproducible, steady-state levels of systemic hypotension, hypoperfusion, and peripheral vasoconstriction, i.e., hemorrhagic shock. This was associated with disproportionate degrees of mesenteric ischemia due to disproportionate mesenteric vasoconstriction. The selective component of this mesenteric vasoconstrictive response was not attenuated by a-adrenergic blockade nor by vasopressin blockade but was blocked by ablation of the renin-angiotensin axis with enalapril. Like cardiogenic shock, hemorrhagic shock generates selective mesenteric ischemia by producing a disproportionate mesenteric vasospasm that is mediated primarily by the renin-angiotensin axis.
authors.affiliation: Department of Anesthesiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-4685, USA.
authors.forename: T
authors.initials: T
authors.lastname: Toung
authors.forename: P M
authors.initials: PM
authors.lastname: Reilly
authors.forename: K C
authors.initials: KC
authors.lastname: Fuh
authors.forename: R
authors.initials: R
authors.lastname: Ferris
authors.forename: G B
authors.initials: GB
authors.lastname: Bulkley
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004656:Enalapril / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D010643:Phenoxybenzamine / Q000494:pharmacology; D012039:Regional Blood Flow; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D013152:Splanchnic Circulation / Q000187:drug effects / Q000502:physiology*; D013552:Swine; D014661:Vasoconstriction / Q000502:physiology*
chemical_list: D010643:Phenoxybenzamine; D004656:Enalapril