title: The first total synthesis of annonacin, the most typical monotetrahydrofuran annonaceous acetogenins.
abstract: The first total synthesis of annonacin (1) was achieved by a highly convergent synthetic strategy. All the stereogenic centers were derived from three natural hydroxy acids respectively, except that those at C19 and C20 were produced from a Sharpless AD reaction.
authors.affiliation: State Key Laboratory of Bio-organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
authors.forename: T S
authors.initials: TS
authors.lastname: Hu
authors.forename: Y L
authors.initials: YL
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D005663:Furans / Q000138:chemical synthesis*; D007783:Lactones / Q000138:chemical synthesis*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D007783:Lactones; C112079:isomurisolenin; C053442:annonacin