Genetic mapping of a locus associated with bovine chronic interstitial nephritis to chromosome 1.
Chronic interstitial nephritis with diffuse zonal fibrosis (CINF) occurs in Japanese Black cattle (Wagyu) as an autosomal recessive disorder leading to death prior to puberty, first six months or a year of life. We performed a genome-wide scan using microsatellite markers in a Wagyu pedigree segregating for CINF and mapped the CINF locus to bovine chromosome 1. CINF was closest to microsatellites BM9019 and INRA49 (Z score = 12.0; P < 3.4 x 10(-10)).
Kobayashi
N
N
Gifu Prefectural Beef Cattle Research Institute, Japan.
Hirano
T
T
Maruyama
S
S
Matsuno
H
H
Mukoujima
K
K
Morimoto
H
H
Noike
H
H
Tomimatsu
H
H
Hara
K
K
Itoh
T
T
Imakawa
K
K
Nakayama
H
H
Nakamaru
T
T
Sugimoto
Y
Y
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary*; D002875:Chromosomes; D002908:Chronic Disease; D008040:Genetic Linkage; D017404:In Situ Hybridization, Fluorescence / Q000662:veterinary; D009395:Nephritis, Interstitial / Q000150:complications / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree; D051437:Renal Insufficiency / Q000209:etiology / Q000662:veterinary