title: Changes in plasma norepinephrine and endothelin levels and metabolic profile after AT1-receptor blockade in human hypertension.
abstract: In essential hypertensive subjects, acute and chronic administration of losartan was followed by favorable neurohormonal (norepinephrine, endothelin-1) and metabolic changes (microalbuminuria).
authors.affiliation: Department of Medicine, Hospital General La Mancha Centro, Alcazar de San Juan, Spain. jlgarcia@serconet.com
authors.forename: J L
authors.initials: JL
authors.lastname: Rodriguez-Garcia
authors.forename: A
authors.initials: A
authors.lastname: Paule
authors.forename: J
authors.initials: J
authors.lastname: Dominguez
authors.forename: J R
authors.initials: JR
authors.lastname: Garcia-Escribano
authors.forename: M
authors.initials: M
authors.lastname: Vazquez
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*
chemical_list: D000959:Antihypertensive Agents; D019332:Endothelin-1; D019808:Losartan; D009638:Norepinephrine