title: Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid.
abstract: The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.
authors.affiliation: Division of Infectious Diseases, Departments of Internal Medicine and Research, University Hospitals, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Trampuz
authors.forename: M
authors.initials: M
authors.lastname: Wenk
authors.forename: Z
authors.initials: Z
authors.lastname: Rajacic
authors.forename: W
authors.initials: W
authors.lastname: Zimmerli
mesh_terms: D000890:Anti-Infective Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000382:microbiology; D006098:Granulocytes / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000494:pharmacology; D011008:Pneumococcal Infections / Q000378:metabolism*; D017192:Skin Diseases, Bacterial / Q000378:metabolism*; D013203:Staphylococcal Infections / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin