title: Gastroduodenal obstruction from ovarian cancer: imaging features and clinical outcome.
abstract: OBJECTIVE
  The purpose of this study was to describe the imaging features and clinical significance of gastroduodenal obstruction from ovarian cancer.
  
  
  METHODS
  Eleven women with symptomatic gastroduodenal obstruction were identified over a 3-year period of prospective clinicoradiological review of cases managed in a specialist gynaecological oncology unit, during which period 438 women with ovarian cancer were managed. Imaging features were verified by surgery, intervention and clinicoradiological follow-up for a minimum of 12 months or until death. Management and outcome were independently reviewed by a medical oncologist not involved in primary care.
  
  
  RESULTS
  The frequency of gastroduodenal obstruction was 2.5% (11 of 438 women). Disease stages of these women at initial diagnosis were: stage II (four women), stage III (six), stage IV (one). Histology was grade 3 in eight of the 11 women. Symptomatic gastroduodenal relapse occurred at 9-103 months after initial diagnosis (median 20 months). There were five cases of predominant involvement of the gastric body and six of the gastric outlet and duodenum. In six cases, focal mass disease resulted in obstruction, in two cases there was diffuse gastric invasion, and in three cases encysted malignant ascites in the lesser sac caused gastric compression/obstruction - the 'squashed stomach syndrome'. Diagnosis of obstruction was with CT in 10 of 11 cases. Palliative interventional procedures relieved symptoms in these three cases, surgery was performed in three cases and the remainder were treated with chemotherapy and other palliative measures. Two women are alive and well at 16 and 38 months who had loculated ascitic disease. Otherwise median survival was 5 months after symptomatic gastroduodenal involvement.
  
  
  CONCLUSIONS
  Gastroduodenal obstruction is rare in women with ovarian cancer. Identification and drainage of encysted lesser sac ascites as its cause may be associated with long term survival, otherwise the prognosis is poor. CT accurately demonstrates the level and cause of obstruction and gives information about the wider extent of recurrent disease.
authors.affiliation: The Department of Clinical Radiology, St James's University Hospital, Leeds, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Spencer
authors.forename: B A
authors.initials: BA
authors.lastname: Crosse
authors.forename: R A
authors.initials: RA
authors.lastname: Mannion
authors.forename: K K
authors.initials: KK
authors.lastname: Sen
authors.forename: T J
authors.initials: TJ
authors.lastname: Perren
authors.forename: A H
authors.initials: AH
authors.lastname: Chapman
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites / Q000150:complications / Q000000981:diagnostic imaging; D004380:Duodenal Obstruction / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D017219:Gastric Outlet Obstruction / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications*; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000556:secondary; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome