title: The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.
abstract: We have isolated the Schizosaccharomyces pombe orthologue of the Saccharomyces cerevisiae MOB1 gene in a screen designed to enrich for septation mutants. The gene is essential, and cells lacking it display a phenotype typical of septation signalling network mutants. mob1p is located on both spindle pole bodies throughout mitosis. In addition it is also co-localised with the medial ring later in mitosis, and flanks the septum as the medial ring contracts. We also demonstrate that mob1p can be precipitated from cells in a complex with the septation regulating kinase sid2p.
authors.affiliation: Cell Cycle Control Laboratory, ISREC, Chemin des Boveresses, 1066 Epalinges, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Salimova
authors.forename: M
authors.initials: M
authors.lastname: Sohrmann
authors.forename: N
authors.initials: N
authors.lastname: Fournier
authors.forename: V
authors.initials: V
authors.lastname: Simanis
mesh_terms: D000483:Alleles; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000032:analysis / Q000235:genetics*; D002462:Cell Membrane / Q000502:physiology*; D003080:Cold Temperature; D004268:DNA-Binding Proteins; D015966:Gene Expression Regulation, Fungal / Q000502:physiology; D008938:Mitosis / Q000502:physiology*; D009154:Mutation; D010750:Phosphoproteins / Q000032:analysis / Q000235:genetics*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D012440:Saccharomyces / Q000166:cytology* / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000166:cytology* / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins; D015398:Signal Transduction / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C110689:MOB1 protein, S cerevisiae; D010750:Phosphoproteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C499592:TAH11 protein, S cerevisiae; C498281:cdc16 protein, S pombe; C406818:cdt1 protein, S pombe; D011494:Protein Kinases; C113816:Sid2 protein, S pombe