Antiyeast steroidal saponins from Yucca schidigera (Mohave yucca), a new anti-food-deteriorating agent.
A saponin fraction from the stems of Yucca schidigera (Mohave yucca) exhibited potent growth-inhibitory activities against certain food-deteriorating yeasts, film-forming yeasts, and dermatophytic yeasts and fungi. From this fraction, a number of new anti-yeast monodesmosidic spirostanol saponins, named schidigera-saponins A1 (1), A2 (2), A3 (3), B1 (4), C1 (5),C2 (6); 25(R and S) schidigera-saponins D1 (7), D2 (8), E1 (12), F1 (13); and 25(S) schidigera-saponins D3 (9), D4 (10), D5 (11), and F2 (14) were isolated, together with several related known saponins, and the structures were elucidated by spectroscopic methods (see Chart 1). The relationship between the antiyeast activities and the structures of these saponins is described.
Miyakoshi
M
M
Maruzen Pharmaceuticals Co., Ltd., 14703-10, Mukaihigashi-cho, Onomichi-city, Hiroshima 722-0062, Japan. miyakov@iea.att.ne.jp
Tamura
Y
Y
Masuda
H
H
Mizutani
K
K
Tanaka
O
O
Ikeda
T
T
Ohtani
K
K
Kasai
R
R
Yamasaki
K
K
D000818:Animals; D002240:Carbohydrate Sequence; D005516:Food Microbiology; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008969:Molecular Sequence Data; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects* / Q000302:isolation & purification
D012503:Saponins