title: Failure of biliopancreatic diversion in Prader-Willi syndrome.
abstract: BACKGROUND
  Prader-Willi syndrome (PWS) is the most common genetic obesity. Excessive weight gain follows failure-to-thrive in early infancy; in adolescents and young adults, excess body weight can exceed 100%. The hyperphagia associated with PWS is responsible for the early mortality. Dietary restriction, alone or combined with anorexic drugs, are ineffective to induce a permanent weight loss. Thus, surgical treatment of morbid obesity in PWS has been attempted, but gastric restrictive operations are unable to produce stable weight loss. In a small number of patients, favorable results have been reported with biliopancreatic diversion (BPD).
  
  
  METHODS
  A 24-year-old woman with PWS, Pickwickian, at age 21 weighed 80 kg (BMI= 50) and underwent BPD.
  
  
  RESULTS
  3 years after the BPD she regained 21 of the 26 kg lost; somnolence and respiratory difficulties were the same as before surgery. The patient now presents severe reduction of bone mass density, hypochromic anemia, hypoproteinemia, and diarrhea associated with eating.
  
  
  CONCLUSIONS
  The regain of weight following BPD suggests that this procedure alone is not adequate for long-term control of obesity in PWS.
authors.affiliation: Department of Auxology, IRCCS S. Giuseppe Hospital, Istituto Auxologico Italiano Foundation, Verbania, 28921 Italy. gragru@jumpy.it
authors.forename: G
authors.initials: G
authors.lastname: Grugni
authors.forename: G
authors.initials: G
authors.lastname: Guzzaloni
authors.forename: F
authors.initials: F
authors.lastname: Morabito
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion / Q000009:adverse effects* / Q000379:methods; D004734:Energy Metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D009767:Obesity, Morbid / Q000235:genetics / Q000601:surgery; D011218:Prader-Willi Syndrome / Q000235:genetics / Q000601:surgery*; D017211:Treatment Failure