4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB.
4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.
Andres
C J
CJ
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.
Bronson
J J
JJ
D'Andrea
S V
SV
Deshpande
M S
MS
Falk
P J
PJ
Grant-Young
K A
KA
Harte
W E
WE
Ho
H T
HT
Misco
P F
PF
Robertson
J G
JG
Stock
D
D
Sun
Y
Y
Walsh
A W
AW
D001419:Bacteria / Q000201:enzymology*; D002237:Carbohydrate Dehydrogenases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D013844:Thiazoles; D002237:Carbohydrate Dehydrogenases; C023215:UDP-N-acetylmuramate dehydrogenase