title: Bone marrow hypoplasia associated with acute viral hepatitis in four children.
abstract: Four cases of children, aged 2 to 11 years, with acute viral hepatitis and bone marrow hypoplasia are reported. Three patients presented only jaundice and hepatomegaly; one also had liver failure. All the four patients underwent bone marrow aspiration which showed bone marrow aplasia. In two of the four patients a liver biopsy revealed patchy necrosis with inflammatory mononuclear cell infiltrate. Half of the patients received a bone marrow transplantation; the remaining patients were treated by intravenous infusion of immunoglobulins, growth factors and steroids. The main epidemiological and etiological features of such association are also reported.
authors.affiliation: Clinica Pediatrica I, Università degli Studi, Catania.
authors.forename: P
authors.initials: P
authors.lastname: Pavone
authors.forename: F
authors.initials: F
authors.lastname: Greco
authors.forename: A
authors.initials: A
authors.lastname: Fisher
authors.forename: L
authors.initials: L
authors.lastname: Zancan
authors.forename: A
authors.initials: A
authors.lastname: D'Agata
authors.forename: S
authors.initials: S
authors.lastname: Musumeci
mesh_terms: D001706:Biopsy; D001855:Bone Marrow Diseases / Q000628:therapy* / Q000821:virology*; D016026:Bone Marrow Transplantation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008297:Male
chemical_list: D016756:Immunoglobulins, Intravenous