title: Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome.
abstract: The aim of this study was to examine the role of serum and follicular fluid pro-inflammatory cytokines and vascular endothelial growth factor (VEGF) in the prediction of ovarian hyperstimulation syndrome (OHSS). A total of 156 consecutive women undergoing in-vitro fertilization were recruited. The study group comprised 12 women who subsequently developed moderate (n = 7) or severe (n = 5) OHSS. The two control groups were comprised of a randomized selection of 12 high-risk and 12 low-risk women in whom OHSS did not develop. Serum was collected on days of human chorionic gonadotrophin, oocyte retrieval, and embryo transfer. Serum and follicular fluid concentrations of interleukin (IL)-6, IL-8, tumour necrosis factor-alpha (TNF-alpha), and VEGF were measured. Follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations at the time of embryo transfer were significantly higher in the OHSS compared to the two control groups (P = 0.026 and P = 0.017 respectively). Serum concentrations of TNF-alpha and VEGF showed no statistically significant difference between the OHSS group and the controls at any studied time point. This study suggests that follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations on the day of embryo transfer may serve as early predictors for this syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.
authors.forename: C D
authors.initials: CD
authors.lastname: Chen
authors.forename: H F
authors.initials: HF
authors.lastname: Chen
authors.forename: H F
authors.initials: HF
authors.lastname: Lu
authors.forename: S U
authors.initials: SU
authors.lastname: Chen
authors.forename: H N
authors.initials: HN
authors.lastname: Ho
authors.forename: Y S
authors.initials: YS
authors.lastname: Yang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D004624:Embryo Transfer; D016228:Endothelial Growth Factors / Q000097:blood / Q000378:metabolism; D004958:Estradiol / Q000097:blood; D005260:Female; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism; D016209:Interleukin-8 / Q000097:blood / Q000378:metabolism; D008222:Lymphokines / Q000097:blood / Q000378:metabolism; D016471:Ovarian Hyperstimulation Syndrome / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D011374:Progesterone / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D006063:Chorionic Gonadotropin; D016207:Cytokines; D016228:Endothelial Growth Factors; D015850:Interleukin-6; D016209:Interleukin-8; D008222:Lymphokines; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D011374:Progesterone; D004958:Estradiol