[The prognostic factors for survival in advanced forms of non-small-cell lung cancer].
This study attempted to determinate the prognostic value for survival of various clinical, biological and therapeutical prognostic factors in patients with non-resectable non-small cell lung cancer (NSCLC).


METHODS
We performed a retrospective study on 236 patients with histologically proved unresectable NSCLC. We collected 36 variable and analysed them by univariate and multivariate methods in order to establish their influence on survival.


RESULTS
The global estimated median survival time was 10 month. In univariate analysis were significantly related to survival: age (> 60 years), weight loss (> 5%), local extend of of disease, Karnofsky performance index (< 70%), stage of disease (stage IIIA vs. IIIB, IV), hemoglobinemia (< 10 g%), calcemia, platelet count, radiotherapy total dose (< 50 Gy), Cisplatin chemotherapy. In a Cox regression model, the explanatory variables were: age > 60 years, Karnofsy performance index 70%, stage IIIB and IV, thoracic total radiotherapy dose < 50 Gy. These results led to a classification of the patients into three subgroups (prognostic index).


CONCLUSIONS
We confirm by our analysis the role of independent factors for survival and we obtained three prognostic groups, the best one needs a radio-chemotherapy association.
Miron
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L
Clinica Radio-Oncologică, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Toma
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C
Ciornea
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LT
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality* / Q000628:therapy; D016009:Chi-Square Distribution; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D016019:Survival Analysis