Cupric sulfate intoxication with rhabdomyolysis, treated with chelating agents and blood purification.
We report a case of cupric sulfate intoxication complicated by hemolytic anemia, hepato-renal damage and acute rhabdomyolysis. The patient was successfully treated with dimercaprol, penicillamine, direct hemoperfusion and hemodiafiltration. We discuss the pathophysiology of cupric intoxication, and propose a treatment combined with chelating agents and blood purification.
Takeda
T
T
Department of Traumatology and Critical Care Medicine, Kyorin University School of Medicine, Tokyo.
Yukioka
T
T
Shimazaki
S
S
D000208:Acute Disease; D000293:Adolescent; D002614:Chelating Agents / Q000627:therapeutic use*; D019327:Copper Sulfate / Q000506:poisoning*; D004112:Dimercaprol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017583:Hemodiafiltration; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000628:therapy*
D002614:Chelating Agents; D004112:Dimercaprol; D010396:Penicillamine; D019327:Copper Sulfate