title: [The effect of the combination of vitamin E and C on the oxidative stress parameters in physical exercise].
abstract: The paper outlines the modification of some antioxidant enzymes and of reduced glutathione studied on physical training induced oxidative stress model. We also assessed vitamin E and C effect. Biochemical determinations were performed on heart homogenate and erythrocytes. Catalase and glutathione peroxidase activity diminished and superoxide dismutase activity increased to a different extent in both tissue samples, while coupled vitamin E and C protection to these tissues equally varied. The glutathione (GSH) pool decreased in erythrocytes and was moderately enhanced in the heart. Either in red blood cells or heart tissue GSH level constancy was maintained by simultaneous administration of vitamins through the experiment (training period). Malondialdehyde concentration revealed a slightly pro-oxidative behaviour of this couple of vitamins that explained the only partial recovery of enzymatic activity to normal values as well as a moderate lipid peroxidation process. Both phenomena were better expressed in erythrocytes.
authors.affiliation: Disciplina de Biochemie Medicală, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: I
authors.initials: I
authors.lastname: Păduraru
authors.forename: M
authors.initials: M
authors.lastname: Ciocoiu
authors.forename: E
authors.initials: E
authors.lastname: Petrescu
authors.forename: A
authors.initials: A
authors.lastname: Saramet
authors.forename: V
authors.initials: V
authors.lastname: Colev
authors.forename: O
authors.initials: O
authors.lastname: Păduraru
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D006321:Heart / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid