title: Clinical and angiographic outcome after coronary arterial stenting with the carbostent.
abstract: The Carbostent is a new balloon-expandable, stainless steel, tubular stent with innovative multicellular design and unique turbastratic carbon coating (Carbofilm). This open nonrandomized 2-center study assesses the immediate and long-term clinical and angiographic outcomes after Carbostent implantation in patients with native coronary artery disease. The Carbostent was implanted in 112 patients with 132 de novo lesions. Most patients (55%) had unstable angina, and 38% of lesions were type B2-C. The mean lesion length was 12.5 +/- 7.0 mm, and 29% of lesions were > 15 mm in length. No stent deployment failure occurred, as well as acute or sub-acute stent thrombosis. The 6-month event-free survival was 84 +/- 4%. One patient with a stented right coronary artery and no restenosis at the angiographic follow-up died after 6 months of fatal infarction due to abrupt closure of a nontarget vessel. In-hospital non-Q-wave myocardial infarction occurred in 1 patient, and 11 patients had repeat target lesion revascularization (target lesion revascularization rate 10%). The 6-month angiographic follow-up was obtained in 108 patients (96%) (127 lesions). Angiographic restenosis rate was 11%. The loss index was 0.29 +/- 0.28. The results of this study indicate a potential benefit of Carbostent for the prevention of stent thrombosis and restenosis in these relatively high-risk patients. A larger trial is being planned to confirm these promising results.
authors.affiliation: The Division of Cardiology, Careggi Hospital, Florence, Italy. carddept@tin.it
authors.forename: D
authors.initials: D
authors.lastname: Antoniucci
authors.forename: A
authors.initials: A
authors.lastname: Bartorelli
authors.forename: R
authors.initials: R
authors.lastname: Valenti
authors.forename: P
authors.initials: P
authors.lastname: Montorsi
authors.forename: G M
authors.initials: GM
authors.lastname: Santoro
authors.forename: F
authors.initials: F
authors.lastname: Fabbiocchi
authors.forename: L
authors.initials: L
authors.lastname: Bolognese
authors.forename: A
authors.initials: A
authors.lastname: Loaldi
authors.forename: M
authors.initials: M
authors.lastname: Trapani
authors.forename: D
authors.initials: D
authors.lastname: Trabattoni
authors.forename: G
authors.initials: G
authors.lastname: Moschi
authors.forename: S
authors.initials: S
authors.lastname: Galli
mesh_terms: D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000000981:diagnostic imaging* / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary; D002244:Carbon; D020099:Coated Materials, Biocompatible; D017023:Coronary Angiography; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D002244:Carbon