title: Genetic mapping of a locus associated with bovine chronic interstitial nephritis to chromosome 1.
abstract: Chronic interstitial nephritis with diffuse zonal fibrosis (CINF) occurs in Japanese Black cattle (Wagyu) as an autosomal recessive disorder leading to death prior to puberty, first six months or a year of life. We performed a genome-wide scan using microsatellite markers in a Wagyu pedigree segregating for CINF and mapped the CINF locus to bovine chromosome 1. CINF was closest to microsatellites BM9019 and INRA49 (Z score = 12.0; P < 3.4 x 10(-10)).
authors.affiliation: Gifu Prefectural Beef Cattle Research Institute, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: T
authors.initials: T
authors.lastname: Hirano
authors.forename: S
authors.initials: S
authors.lastname: Maruyama
authors.forename: H
authors.initials: H
authors.lastname: Matsuno
authors.forename: K
authors.initials: K
authors.lastname: Mukoujima
authors.forename: H
authors.initials: H
authors.lastname: Morimoto
authors.forename: H
authors.initials: H
authors.lastname: Noike
authors.forename: H
authors.initials: H
authors.lastname: Tomimatsu
authors.forename: K
authors.initials: K
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Imakawa
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Nakamaru
authors.forename: Y
authors.initials: Y
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary*; D002875:Chromosomes; D002908:Chronic Disease; D008040:Genetic Linkage; D017404:In Situ Hybridization, Fluorescence / Q000662:veterinary; D009395:Nephritis, Interstitial / Q000150:complications / Q000235:genetics / Q000662:veterinary*; D010375:Pedigree; D051437:Renal Insufficiency / Q000209:etiology / Q000662:veterinary