New Agents in the Management of Non-Small Cell Lung Cancer.
BACKGROUND: Non-small-cell carcinoma of the lung has long been considered a chemotherapeutically resistant neoplasm. Newer agents and combinations are being tested. METHODS: The authors have reviewed data on recent and active phase I and phase II trials of several new agents and combinations. RESULTS: New drugs that affect both response rates and survival include vinorelbine, paclitaxel, docetaxel, gemcitabine, topotecan, and irinotecan. CONCLUSIONS: The advent of several relatively well-tolerated agents that alone have beneficial effects in advanced non-small-cell lung cancer provides reasonable hope that more effective drug combinations will soon be available for this disease.
Chiappori
A
Vanderbilt University Medical Center, Vanderbilt Cancer Center, Nashville, Tennessee 37232-2561, USA.
DeVore
RF
Johnson
DH