Differential expression of chemokine receptor CXCR4 in Th1 and Th2 subtypes of CD4+ lymphocytes.
Different cytokine profiles allow to divide the CD4+ lymphocytes into Th1, Th2 and Th0 subtypes. It has been observed that the Th2 cells are more efficient supporters for HIV-1 replication than the Th1 cells. The Th1 and the Th2 cells were isolated from peripheral blood lymphocytes of HIV-1 seronegative individuals and the density of CXCR4 receptors was determined by flow cytometry using antibodies directed against the CXCR4 receptor. Flow cytometric analysis revealed higher expression of the HIV-1 co-receptor CXCR4 on Th2 cells than on the Th1, which might explain better replication of HIV-1 viruses in the Th2 cells.
Jagodziński
P P
PP
Department of Physiological Chemistry, University of Medical Sciences, Poznań, Poland. pjagodzi@eucalyptus.usoms.poznan.pl
Trzeciak
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WH
D000906:Antibodies; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D018791:CD4 Lymphocyte Count / Q000379:methods*; D005434:Flow Cytometry; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1; D006801:Humans; D019718:Receptors, CXCR4 / Q000032:analysis* / Q000276:immunology; D018417:Th1 Cells / Q000737:chemistry / Q000166:cytology* / Q000821:virology; D018418:Th2 Cells / Q000737:chemistry / Q000166:cytology* / Q000821:virology
D000906:Antibodies; D000954:Antigens, Surface; D019718:Receptors, CXCR4