Bone turnover in short-term and long-term home parenteral nutrition for benign disease.
6 mo afterward. Long-HPN was assessed only at baseline. In short-HPN, there was a hyperkinetic turnover at baseline. At follow-up, OC was similar to baseline, whereas cross-links, urinary calcium and magnesium decreased (P < 0.03), and parathyroid hormone increased (P < 0.001). The variation of urinary calcium correlated with that of cross-links (r = 0.73, P < 0.04). In long-HPN, OC was low or low-normal in almost all the patients, and cross-links were normal. Mean OC was lower than that of short-HPN both at baseline (P < 0. 003) and at follow-up (P < 0.002). The results suggest that in the early period of HPN bone metabolism improved from a hyperkinetic turnover to a positive balance. A low bone-formation rate appeared to be a characteristic feature of long-term HPN.
Pironi
L
L
First Internal Medicine Unit, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy. pironi@med.unibo.it
Zolezzi
C
C
Ruggeri
E
E
Paganelli
F
F
Pizzoferrato
A
A
Miglioli
M
M
D000328:Adult; D000368:Aged; D000535:Aluminum / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000652:urine; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000628:therapy*; D008274:Magnesium / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D016331:Parenteral Nutrition, Home; D010758:Phosphorus / Q000097:blood / Q000652:urine; D013997:Time Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood
D000596:Amino Acids; D015415:Biomarkers; D010281:Parathyroid Hormone; D015675:Osteocalcin; D014807:Vitamin D; D010758:Phosphorus; C015484:pyridinoline; C097949:1,25-dihydroxyvitamin D; C036020:deoxypyridinoline; C104450:25-hydroxyvitamin D; D000535:Aluminum; D008274:Magnesium; D002118:Calcium