Synthesis of a cyanopeptide-analogue with trypsin activating properties.
An efficient synthesis of a peptidic analogue of cyanobacterial metabolites with proposed serine protease inhibitory activity has been developed. Surprisingly, one trypsin activating compound was obtained.
Radau
G
G
Institute of Pharmacy, Ernst-Moritz-Arndt-University, Pharmaceutical/Medicinal Chemistry, Greifswald, Germany. radau@pharmazie.uni-greifswald.de
Rauh
D
D
D003486:Cyanides / Q000737:chemistry; D004789:Enzyme Activation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D014357:Trypsin / Q000378:metabolism*
D003486:Cyanides; D010455:Peptides; D015842:Serine Proteinase Inhibitors; D014357:Trypsin