[The Human Genome Project and the genetics of infertility].
Nine years after the beginning and five years before the expected end of the Human Genome Project, we will have access in several months to 90% of the human genome sequence. This data certainly opens promising vistas to the better understanding of gametogenesis. This will allow the different types of sterility to be studied through new approaches. The aim of the current review is to describe how the Human Genome Project has proceeded in the last ten years. We also discuss to what extent the knowledge of the human genome sequence is important in understanding the genetic basis of some diseases, such as human infertility. Finally, we review the different methodologies to use this information and their limits.
Jamain
S
S
Inserm U 276, Institut Pasteur, Paris, France.
Vialard
F
F
Bourgeron
T
T
Fellous
M
M
D004989:Ethics; D005260:Female; D016045:Human Genome Project; D006801:Humans; D007246:Infertility / Q000235:genetics*; D008297:Male; D017422:Sequence Analysis, DNA