[Changes in the activity of superoxide dismutase, glutathione peroxidase, microsomal lipid peroxidation, and content of trace elements in organs and tissues following copper introduction].
Chronic application of various copper concentrations on the skin decreases endogenous levels of iron, zinc, and copper in the serum. Single introduction of disperse copper positively correlates with the level of the oxidation products and Fe/Zn ratio in the liver. Single introduction of ionic and electron-neutral copper induces phased changes in superoxide dismutase and glutathione peroxidase activities. Positive correlation between activities of these enzymes points to efficient control of O2-radicals, dismutation products, and hydroperoxides level by the antioxidant enzymes in animal tissues treated with copper.
Bogoslovskaia
O A
OA
Institute of Energy Problems of Chemical Physics, Russian Academy of Sciences, Moscow, Russia.
Ol'khovskaia
I P
IP
Glushchenko
N N
NN
D000279:Administration, Cutaneous; D000818:Animals; D003300:Copper / Q000097:blood / Q000633:toxicity*; D004785:Environmental Pollutants / Q000097:blood / Q000633:toxicity*; D004912:Erythrocytes / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006168:Guinea Pigs; D006454:Hemoglobins; D007279:Injections, Subcutaneous; D007501:Iron / Q000097:blood; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*; D014131:Trace Elements / Q000097:blood / Q000378:metabolism*; D015032:Zinc / Q000097:blood
D004785:Environmental Pollutants; D006454:Hemoglobins; D014131:Trace Elements; D003300:Copper; D007501:Iron; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D015032:Zinc