Antiphospholipid syndrome and factor V Leiden. Three cases with recurrent venous thrombosis.
Recurrent thrombosis is a common complication of various rheumatic disorders and is part of the definition of antiphospholipid syndrome. We report three cases of recurrent venous thrombosis due not only to antiphospholipid syndrome with a normal activated partial thromboplastin time but also to resistance to activated protein C caused by the factor V Leiden mutation. These three cases confirm that thrombotic disease is frequently multifactorial and suggest that resistance to activated protein C should be looked for routinely in patients with suggestive clinical manifestations, particularly when standard clotting tests are normal.
Guis-Sabatier
S
S
Service de Rhumatologie, Hôpital de la Conception, Marseille, France.
Roudier
J
J
Arnoux
D
D
Rochwerger
A
A
Roux
H
H
Mattei
J P
JP
D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D020246:Venous Thrombosis / Q000209:etiology* / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V