title: Hard metal alveolitis accompanied by rheumatoid arthritis.
abstract: Hard metal lung diseases (HML) are rare, and complex to diagnose. We describe the case of a patient with allergic alveolitis accompanied by rheumatoid arthritis. A sharpener of hard metal by trade, our patient was a 45-year-old, nonsmoking Caucasian female who experienced symptoms of cough and phlegm, and dyspnea on exertion. Preliminary lung findings were inspiratory rales in both basal areas, decreased diffusion capacity and a radiological picture resembling sarcoidosis. A high-resolution computed tomography scan indicated patchy alveolitis as well. An open lung biopsy revealed non-necrotizing granulomas consisting of epitheloid cells and surrounded by lymphocytes, plasma cells and a few eosinophils. These cells also occupied the thickened alveolar interstitium. Macrophages in the alveolar spaces, some of them multinuclear, contained dust particles. Hard metal alveolitis is clinically well known and, in this patient, has been described histologically. After the patient had quit working with hard metal and following corticosteroid therapy, pulmonary symptoms and signs were relieved. During this recovery period, however, she contracted rheumatoid arthritis.
authors.affiliation: Tampere University Hospital, Department of Pulmonary Diseases, Tampere, Finland. hahtola@sci.fi
authors.forename: P A
authors.initials: PA
authors.lastname: Hahtola
authors.forename: R E
authors.initials: RE
authors.lastname: Järvenpää
authors.forename: K
authors.initials: K
authors.lastname: Lounatmaa
authors.forename: J J
authors.initials: JJ
authors.lastname: Mattila
authors.forename: I
authors.initials: I
authors.lastname: Rantala
authors.forename: J A
authors.initials: JA
authors.lastname: Uitti
authors.forename: S
authors.initials: S
authors.lastname: Sutinen
mesh_terms: D000497:Alloys / Q000009:adverse effects*; D000542:Alveolitis, Extrinsic Allergic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000209:etiology*; D001706:Biopsy; D003035:Cobalt / Q000009:adverse effects*; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000209:etiology / Q000473:pathology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014414:Tungsten / Q000009:adverse effects*
chemical_list: D000497:Alloys; C080121:hard metal; D003035:Cobalt; D011239:Prednisolone; D014414:Tungsten