Development of pemphigus vulgaris in a patient with pemphigus foliaceus: antidesmoglein antibody profile shift confirmed by enzyme-linked immunosorbent assay.
We describe a patient with pemphigus foliaceus (PF) in whom pemphigus vulgaris (PV) subsequently developed. The clinical change was accompanied by a shift of autoantibody profile confirmed by enzyme-linked immunosorbent assay. Antidesmoglein (Dsg) 1 antibodies alone were detected in the PF stage, whereas both anti-Dsg3 and anti-Dsg1 antibodies were detected in the PV stage.
Ishii
K
K
Department of Dermatology, Keio University School of Medicine, Saiseikai Central Hospital, Tokyo, Japan. ishii@mc.med.keio.ac.jp
Amagai
M
M
Ohata
Y
Y
Shimizu
H
H
Hashimoto
T
T
Ohya
K
K
Nishikawa
T
T
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001324:Autoantigens / Q000276:immunology*; D015820:Cadherins / Q000276:immunology*; D051183:Desmoglein 1; D003937:Diagnosis, Differential; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000150:complications / Q000209:etiology / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D015820:Cadherins; D051183:Desmoglein 1