Retinoblastoma protein in microphthalmic mice.
A microphthalmic strain of mice was used to study immunoresponse of the retinoblastoma protein. Comparing wild-type, heterozygote and homozygote microphthalmic eyes, we found an increasing labelling of phosphorylated retinoblastoma protein (pRb) in the retinal pigment epithelium. Additionally, microphthalmic eyes expressed pRb in the neuroepithelium. Especially rosettes were strongly labelled.
Richter
J
J
Institute of Anatomy, University of Leipzig, Germany.
Brylla
E
E
Lenk
C
C
Ernstberger
J
J
Hilbig
H
H
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008850:Microphthalmos / Q000276:immunology / Q000473:pathology*; D012160:Retina / Q000737:chemistry; D019572:Retinal Neoplasms / Q000276:immunology / Q000473:pathology*; D012175:Retinoblastoma / Q000276:immunology / Q000473:pathology*; D016160:Retinoblastoma Protein / Q000096:biosynthesis / Q000276:immunology* / Q000494:pharmacology
D016160:Retinoblastoma Protein