Proinflammatory and regulatory cytokine levels in AIDS cachexia.
The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflammatory cytokines (Interleukin-1, Interleukin-6, Tumor necrosis Factor alpha) and a decrease in regulatory cytokines such as Interleukin-12 were found. A significant correlation resulted between weight loss and Interleukin-1 beta and 6. A negative correlation between Interleukin-1 and 12 was noted, indicating that this last cytokine has an important regulatory role also in advanced state of the disease.
Baronzio
G
G
Hyperthermia and Oncology Session, Centri Clinici Chirurgici Padre Pio, Va, Italy. barongf@infoplus.it
Zambelli
A
A
Comi
D
D
Barlocco
A
A
Baronzio
A
A
Marchesi
P
P
Gramaglia
A
A
Castiglioni
E
E
Mafezzoni
A
A
Beviglia
E
E
Crespi
F
F
Cargnel
A I
AI
Pravettoni
G
G
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D019247:HIV Wasting Syndrome / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015431:Weight Loss
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12