[Computer system for simulating population dynamic patterns of polygenes and mobile genetic elements upon truncation selection for a quantitative trait].
A computer system was developed for simulation of population dynamics of interacting polygene patterns and mobile genetic elements (MGEs) under selection for a quantitative trait. The system is stochastic (Monte Carlo) and takes into account the main sources of random change in the patterns (recombinations, transpositions, excisions), genetic drift, and determined trends of selection and other genetic processes in a finite population. Using this model, it is possible to analyze the dynamics of many population parameters that cannot be experimentally estimated: frequencies of polygenic alleles, proportions of adaptive and random fixations, average heterozygosities of polygenes and MGEs, coefficient of inbreeding, heritability, etc. In addition, the model can be used to test various hypotheses on polygene-MGE interaction.
Ratner
V A
VA
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia. ratner@cgi.nsk.su
Iudanin
A Ia
AIa
D000222:Adaptation, Physiological; D003198:Computer Simulation; D005828:Genetics, Population; D020071:Interspersed Repetitive Sequences; D011157:Population Dynamics; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic