HIV-1 co-receptor CCR5 and CCR2 mutations among Greeks.
The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5Delta32 allele among the HIV-negative subjects was 0.052, while it was approximately two-fold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.
Papa
A
A
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece. annap@med.auth.gr
Papadimitriou
E
E
Adwan
G
G
Clewley
J P
JP
Malissiovas
N
N
Ntoutsos
I
I
Alexiou
S
S
Antoniadis
A
A
D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006115:Greece; D015658:HIV Infections / Q000235:genetics*; D018023:HIV Seronegativity / Q000235:genetics; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D009154:Mutation; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine / Q000235:genetics*; D015728:Receptors, HIV / Q000235:genetics*
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D015728:Receptors, HIV