Movement-related electroencephalographic desynchronization in patients with hand cramps: evidence for motor cortical involvement in focal dystonia.
We studied the dynamic changes in the amplitude of scalp electroencephalographic (EEG) oscillations to self-paced simple index finger abduction movements in patients with writer's cramp and compared them with those of normal aged-matched controls. The changes in EEG oscillations were measured in predefined frequency bands (8-10, 10-12, 12-20, and 20-30 Hz) by using the event-related desynchronization technique. Movements of the affected and unaffected hand in patients with writer's cramp showed significantly less reduction in 20- to 30-Hz power compared with controls. The differences in movement-related EEG power decline were apparent over the contralateral central and midline regions before and after electromyographic onset. Because EEG beta rhythm in the sensorimotor region likely emanates from the motor cortex and is related to ongoing muscle activity, this abnormality could be a manifestation of the abnormal motor command at the cortical level.
Toro
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C
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA.
Deuschl
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G
Hallett
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D000328:Adult; D000368:Aged; D003344:Cortical Synchronization; D020821:Dystonic Disorders / Q000503:physiopathology*; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006225:Hand / Q000503:physiopathology; D006236:Handwriting; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000166:cytology / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D009068:Movement / Q000502:physiology*; D009120:Muscle Cramp / Q000503:physiopathology*