Synthesis and antifungal activity of a ferrocene-fluconazole analogue.
A novel ferrocene fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations.
Biot
C
C
Laboratoire de Catalyse de Lille, Groupe de Synthèse Organométallique, UPRESA CNRS 8010, Ecole Nationale Supérieure de Chimie de Lille, Villeneuve d'Ascq, France. ch_biot@club-internet.fr
François
N
N
Maciejewski
L
L
Brocard
J
J
Poulain
D
D
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry / Q000494:pharmacology*; D015725:Fluconazole / Q000737:chemistry / Q000494:pharmacology*; D000075163:Metallocenes; D008826:Microbial Sensitivity Tests; D013045:Species Specificity
D000935:Antifungal Agents; D005296:Ferrous Compounds; D000075163:Metallocenes; D015725:Fluconazole; C004998:ferrocene