Poxviral mimicry of complement and chemokine system components: what's the end game?
Numerous viral proteins mimic host immunoregulatory proteins, both structurally and functionally. This phenomenon appears to underlie viral evasion of host defense. These viral immunomodulatory proteins block viral neutralization and destruction of infected cells, and are also able to influence their habitat, preserving habitats that favor their growth and that of their progeny. The end game seems to vary widely among viruses.
Kotwal
G J
GJ
Dept of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA. gjkotw01@gwise.louisville.edu
D000276:Adjuvants, Immunologic / Q000235:genetics; D000818:Animals; D018925:Chemokines / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D016384:Consensus Sequence; D016679:Genome, Viral; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D018716:Molecular Mimicry; D011212:Poxviridae / Q000235:genetics / Q000276:immunology*; D011213:Poxviridae Infections / Q000276:immunology; D019707:Receptors, Chemokine / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
D000276:Adjuvants, Immunologic; D018925:Chemokines; D018836:Inflammation Mediators; D019707:Receptors, Chemokine; D014764:Viral Proteins; D003165:Complement System Proteins