title: Early-onset periodontitis in a patient with Ehlers-Danlos syndrome type III.
abstract: This case history describes the course of disease in a 17-year-old boy with Ehlers-Danlos syndrome type III and early-onset periodontitis. Flow cytometric tests showed a reduced cell count in the specific immune system. Immunoglobulin concentrations in saliva and serum were within normal limits. Infection with T-lymphotropic viruses was excluded. The phagocytic capacity of the peripheral blood polymorphonuclear leukocytes was unimpaired. The anaerobic infection present in the early-onset periodontitis was treated with systemic antibiotic therapy and closed curettage. Following 14 days of this treatment, signs of acute inflammation subsided, and 18 months after therapy ended, a slight gain in clinical attachment was found, and bone growth was visible via radiology. However, a continuing lack of adequate oral hygiene represents a risk to the success of therapy in the long term.
authors.affiliation: Outpatient Clinic for Restorative Dentistry/Periodontology, Martin Luther University Halle-Wittenberg, Faculty of Medicine, Saale, Germany. stefan.reichert@medizin.uni-halle.de
authors.forename: S
authors.initials: S
authors.lastname: Reichert
authors.forename: D
authors.initials: D
authors.lastname: Riemann
authors.forename: B
authors.initials: B
authors.lastname: Plaschka
authors.forename: H K
authors.initials: HK
authors.lastname: Machulla
mesh_terms: D000293:Adolescent; D010520:Aggressive Periodontitis / Q000209:etiology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001421:Bacteria, Anaerobic; D001424:Bacterial Infections / Q000188:drug therapy; D004535:Ehlers-Danlos Syndrome / Q000150:complications*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D013357:Subgingival Curettage
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin