[Bepridil: importance of serum level in treatment surveillance].
OBJECTIVE
Despite precise recommendations for prescription and monitoring, tosades de pointes is still observed with bepridil. The purpose of this study was to demonstrate the contribution of bepridil serum assay in therapeutic supervision.


METHODS
Seventy-five patients over 70 years of age were included. Prolongation of the QT interval was observed in 23 patients.


RESULTS
The potential prognostic factors for increased QT interval as demonstrated by univariate logistic regression were hypokaliemia, bradycardia, renal failure and bepridil serum level. After multivariate logistic regression, the persisting causal factors for increased QT interval were hypokaliemia, bradycardia and bepridil serum level.


CONCLUSIONS
Prolongation of the QT interval remains dependent on several variables. Bepridil determination during treatment is insufficient alone.
Viallon
A
A
Service d'Urgence et de Réanimation, Hôpital de bellevue, Saint-Etienne. alain.viallon@univ-st-etienne.fr
Laporte-Simitsidis
S
S
Pouzet
V
V
Venet
C
C
Tardy
B
B
Zéni
F
F
Bertrand
J C
JC
D000368:Aged; D000369:Aged, 80 and over; D015764:Bepridil / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D016903:Drug Monitoring; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000097:blood / Q000139:chemically induced*; D008297:Male; D012307:Risk Factors; D016171:Torsades de Pointes / Q000097:blood / Q000139:chemically induced*
D015764:Bepridil