Synthesis of oligodeoxyribonucleotides bearing a functional group at 2'-position by post-synthetic modification.
A novel 2'-thio-2'-deoxyuridine derivative bearing a reactive ester at 2'-position was synthesized and incorporated into oligodeoxyribonucleotides (ODNs) for the post-synthetic modification of ODNs. This ODNs was reacted with several amines to give ODNs having a functional group at 2'-position.
Ozaki
H
H
Faculty of Engineering, Gunma University, Kiryu, Japan.
Momiyama
S
S
Yokotsuka
K
K
Sawai
H
H
D019281:Dimerization; D007202:Indicators and Reagents; D008968:Molecular Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides