Differentiation inducing activities of isocoumarins from Hydrangea Dulcis Folium.
In the course of searching for differentiation inducers against leukemic cells from plants, we have recognized the differentiation inducing activities of the methanolic extract of Hydrangea Dulcis Folium. Activity guided separation of the extract was carried out using M1 cells, and seven isocoumarins were isolated as active substances. These isocoumarins showed the activities at the concentration of 100 microM and non-cytotoxic effects even at 300 microM.
Umehara
K
K
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Matsumoto
M
M
Nakamura
M
M
Miyase
T
T
Kuroyanagi
M
M
Noguchi
H
H
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D003374:Coumarins / Q000494:pharmacology*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008956:Models, Chemical; D010944:Plants / Q000737:chemistry*; D013329:Structure-Activity Relationship
D003374:Coumarins