title: Quantitative planar imaging method for measurement of renal activity by using a conjugate-emission image and transmission data.
abstract: We are proposing a method to accurately measure renal activity in renography using Tc-99m labeled tracers. This method uses a conjugate-view image and transmission data for attenuation correction, the triple energy window (TEW) method for scatter correction, and background correction techniques that consider the source volume for accurate background activity correction. To examine this method in planar imaging, we performed two renal phantom studies with various uniform background activity concentrations. One study used two ideal box-shaped kidney phantoms with a thickness of 2 or 4 cm in a water tank and the other study employed two real kidney-shaped phantoms in a fillable abdominal cavity. For these studies the kidney phantom-to-background activity concentration ratio (S) was changed from 5 to infinity. The transmission data were obtained with an external Tc-99m line array source. The anterior- and posterior-view emission images were acquired with a dual-headed gamma camera simultaneously and the TEW method was used to correct scatter for the emission and transmission images. The results showed that this method with both the accurate background correction and scatter correction could give depth-independent count rates and could estimate the true count rate with errors of less than 5% for all S values. However, if either accurate background correction or scatter correction was performed alone, the absolute error increased to about 50% for the smaller S values. Our proposed method allows one to accurately and simply measure the renal radioactivity by planar imaging using the conjugate-emission image and transmission data.
authors.affiliation: Radioisotope Research Center, Kumamoto University, Japan. akojima@kaiju.medic.kumamoto-u.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Kojima
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyama
authors.forename: S
authors.initials: S
authors.lastname: Tomiguchi
authors.forename: M
authors.initials: M
authors.lastname: Kira
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Motomura
authors.forename: T
authors.initials: T
authors.lastname: Ichihara
mesh_terms: D007668:Kidney / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D011866:Radioisotope Renography / Q000379:methods; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics* / Q000627:therapeutic use; D012542:Scattering, Radiation; D013667:Technetium / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D019275:Radiopharmaceuticals; D013667:Technetium