[Ginkgo biloba extract (EGb 761) as an antioxidant factor of exogenous origin].
Extracted from Ginkgo biloba leaves, the EGb 761 has a great number of therapeutical properties and anti-stress effects, for example the antioxidant one. We estimated in our experiment the influence of a chronic treatment with EGb 761 on the concentration of the main product of lipidic degradation--malondialdehyde (MDA), in cerebral cortex, in diencephalon, thymus and gastric mucosa. The experiment was performed on Wistar rats, male, young. The MDA estimation was performed by the spectrocalorimetry. We have determined that the stress raised the MDA concentration in all examined structures with approximately 100% and 80% of animals manifested stress ulcer. The treatment with EGb 761 before a stress inhibits the post-stress growth of MDA concentration and the process of stress ulcer formation.
Butnaru
M
M
Disciplina de Fiziologie Animală, Universitatea Al.I. Cuza, Iaşi.
Iacobovici
A
A
Haulică
I
I
Hefco
V
V
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use*; D020441:Ginkgo biloba / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy / Q000378:metabolism; D000096983:Ginkgo Extract
D000975:Antioxidants; D005419:Flavonoids; D008315:Malondialdehyde; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract