Pathophysiology of the intrahepatic biliary epithelium.
The intrahepatic bile duct epithelium modulates the fluidity and alkalinity of the primary hepatocellular bile from which it reabsorbs fluids, amino acids, glucose and bile acids, while secreting water, electrolytes and immunoglobulin A. The transport function of the intrahepatic biliary epithelium is finely regulated by a number of gastrointestinal hormones, neuropeptides and neurotransmitters that promote either secretion or absorption. The intrahepatic biliary epithelium appears to be a primary target in a broad group of chronic cholestatic disorders that represent an important cause of morbidity and mortality. The spectrum of cholangiopathies ranges from conditions in which a normal epithelium is damaged by disordered autoimmunity, infectious agents, toxic compounds or ischaemia, to genetically determined disorders arising from an abnormal bile duct biology, such as cystic fibrosis or biliary atresia. Probably as a result of the known heterogeneity in cholangiocyte function, different portions of the biliary tree appear to be preferentially affected in specific cholangiopathies. From a pathophysiological point of view, cholangiopathies are characterized by the coexistence of cholangiocyte loss (by apoptotic or lytic cell death) with cholangiocyte proliferation and various degrees of portal inflammation, fibrosis and cholestasis. These basic disease mechanisms are discussed in detail. Better understanding of cholangiocyte pathophysiology, in particular the immune regulation of cholangiocyte function, will help in designing newer genetic or pharmacological approaches to treat cholangiopathies.
Strazzabosco
M
M
Department of Medical and Surgical Sciences, University of Padova and Azienda Ospedaliera di Padova, Italy. mstrazza@ux1.unipd.it
Spirlí
C
C
Okolicsanyi
L
L
D000042:Absorption; D017209:Apoptosis; D001649:Bile Duct Diseases / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001653:Bile Ducts, Intrahepatic / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001692:Biological Transport; D002455:Cell Division; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005768:Gastrointestinal Hormones / Q000378:metabolism; D006801:Humans; D009479:Neuropeptides / Q000378:metabolism
D005768:Gastrointestinal Hormones; D009479:Neuropeptides