Cubilin, a high-density lipoprotein receptor.
The metabolism of HDL particles is a complex biological process involving various regulating factors in plasma and different cellular receptors. In addition to the well-established scavenger receptor BI-mediated selective HDL-cholesteryl ester uptake in liver and steroidogenic tissues, evidence has been provided that HDL also undergoes holoparticle endocytosis in different tissues. Recently, a novel receptor expressed in various absorptive epithelia was disclosed as a high affinity receptor for endocytosis of HDL and lipid-poor apolipoprotein AI. This receptor, designated cubilin, may play an important role in the renal clearance of filterable apolipoprotein AI/HDL and in the maternal-fetal transport of cholesterol.
Moestrup
S K
SK
Department of Medical Biochemistry, University of Aarhus, Denmark. skm@biobase.dk
Kozyraki
R
R
D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism; D002352:Carrier Proteins; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008024:Ligands; D008075:Lipoproteins, HDL; D008954:Models, Biological; D016601:RNA-Binding Proteins; D051381:Rats; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018110:Receptors, Lipoprotein / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism; D015017:Yolk Sac / Q000378:metabolism
D016632:Apolipoprotein A-I; D002352:Carrier Proteins; D008024:Ligands; D008075:Lipoproteins, HDL; D016601:RNA-Binding Proteins; D011956:Receptors, Cell Surface; D018110:Receptors, Lipoprotein; D018000:Receptors, Peptide; C031616:high density lipoprotein receptors; C028199:intrinsic factor receptor; C029486:intrinsic factor-cobalamin receptor; C075197:high density lipoprotein binding protein