Insufficient evidence of TT-viral etiology of post hepatitis aplastic anemia.
Post-hepatitis aplastic anemia is a rather rare pathologic condition of as yet unclear etiology especially as hepatitis viruses A to G have been excluded as the potential agents responsible. The novel TT virus, a single-stranded DNA virus first isolated from the serum of a patient with post-transfusion hepatitis in Japan might cause this condition. Therefore, our group subjected the sera of two children with post-hepatitis aplastic anemia to semi-nested PCR using primers specific for detection of TTV DNA. Although TTV DNA was not detectable in either sample it might be speculated that, like hepatitis viruses A to G, TTV could be found associated with this condition whereas it certainly does not constitute its sole etiologic agent.
Poovorawan
Y
Y
Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, Thailand. Yong.P@chula.ac.th
Theamboonlers
A
A
Seksarn
P
P
D000741:Anemia, Aplastic / Q000821:virology*; D002648:Child; D004266:DNA Virus Infections / Q000097:blood / Q000150:complications* / Q000235:genetics; D004279:DNA, Viral / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000821:virology; D006801:Humans
D004279:DNA, Viral