title: Right temporal lobe glioblastoma presenting in the left orbit. Case report.
abstract: Dissemination of gliomas outside the central nervous system without preceding neurosurgery is a rare phenomenon. Glial neoplasms presenting as bone lesions are even more rare. A case of glioblastoma multiforme (GBM) with initial presentation in the orbit following a single generalized seizure is described. Signs of intracranial hypertension resulted from subarachnoid tumor invasion. The patient was treated with whole-dose radiation therapy but survived for only 6 months following the initial presentation. An autopsy revealed a right temporal GBM with extensive subarachnoid spread and invasion in the left orbit and skull base. The literature on dissemination of primary tumors of the brain is reviewed.
authors.affiliation: Department of Pathology, University Hospital Rotterdam, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Kros
authors.forename: H
authors.initials: H
authors.lastname: van den Berge
authors.forename: H L
authors.initials: HL
authors.lastname: Tanghe
authors.forename: S L
authors.initials: SL
authors.lastname: Bakker
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D004829:Epilepsy, Generalized / Q000175:diagnosis; D017809:Fatal Outcome; D005909:Glioblastoma / Q000175:diagnosis* / Q000532:radiotherapy; D006801:Humans; D019586:Intracranial Hypertension / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D019292:Skull Base Neoplasms / Q000473:pathology; D013346:Subarachnoid Space / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology*