[Therapeutic management of ovarian dystrophy and insufficiency in abortion disorders: recent data].
Many reports suggested that the high rate of miscarriage in women with polycystic ovaries may be due to increased urine and/or plasma LH concentration. In fact, with the exception of pulsatile GnRH, any treatment likely to increase the plasma LH level results in unchanged or rather low miscarriage rates. Conversely, a reduction in this rate by GnRH agonists is not conclusive. Excess weight may also increase the risk of miscarriage. In women with incipient ovarian failure, the miscarriage rate is mainly linked to age. No stimulation has been found to be effective in these patients. There is a need for more extensive evaluation in GnRH analog microdoses, recombinant FSH and GnRH antagonists. Oocyte donations from younger women are difficult to obtain because of the lack of donors in France.
Antoine
J M
JM
Service de gynécologie-obstétrique et médecine de la reproduction, Hôpital Tenon, Paris, France.
Merviel
P
P
Cornet
D
D
Mandelbaum
J
J
Salat-Baroux
J
J
Uzan
S
S
D000022:Abortion, Spontaneous / Q000209:etiology*; D001835:Body Weight; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000627:therapeutic use; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood / Q000652:urine; D010049:Ovarian Diseases / Q000150:complications / Q000628:therapy*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy; D011247:Pregnancy
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone