Genetic factors in immunosuppression: precise genetic evidence that polymorphism of TNF-alpha dictates UVB-susceptibility in mice.
Acute low-dose treatment of murine skin with ultraviolet B (UVB) light impairs induction of contact hypersensitivity (CH) to dinitrofluorobenzene (DNFB) in certain inbred strains of mice (termed UVB-susceptible), but not in others (termed UVB-resistant). These deleterious effects of ultraviolet radiation (UVR) are mediated in part by TNF-alpha, which is released from UVR-exposed epidermal and dermal cells. To test the hypothesis that polymorphism of TNF-alpha governs the phenotype of UVB-susceptibility in vivo, various strains of mice received UVB radiation followed by hapten application to induce contact hypersensitivity. Results suggest that the polymorphism at the Tnf-alpha locus dictates UVB susceptibility in vivo.
Nakamura
T
T
Department of Dermatology, Osaka University Medical School, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Kurimoto
I
I
Itami
S
S
Yoshikawa
K
K
Streilein
J W
JW
D000818:Animals; D003877:Dermatitis, Contact; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000235:genetics / Q000276:immunology; D011110:Polymorphism, Genetic; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D014466:Ultraviolet Rays / Q000009:adverse effects
D014409:Tumor Necrosis Factor-alpha