title: Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element.
abstract: The aminoglycosidic antibiotic, neomycin B, is an inhibitor of the binding of Rev to RRE. This paper reports on the synthesis of analogs of neomycin B as potential anti-HIV compounds designed to function as inhibitors of Rev/RRE binding.
authors.affiliation: Department of Chemistry, University of Iowa, Iowa City 52242, USA.
authors.forename: N
authors.initials: N
authors.lastname: Nishizono
authors.forename: V
authors.initials: V
authors.lastname: Nair
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005601:Framycetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015752:Genes, env / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C411243:5-O-(ethyl-2-(5-amino-5-deoxy-ribofuranosidyl))neamine pentahydrochloride; C411245:5-O-(ethyl-2-(6-amino-6-deoxy-glycopyranosidyl))neamine pentahydrochloride; D019380:Anti-HIV Agents; D014312:Trisaccharides; D005601:Framycetin