title: Primary malignant melanoma arising in the parotid gland: case report and literature review.
abstract: Melanoma of the head and neck is an extremely rare disease, characterized by difficult and late diagnosis and poor prognosis; moreover, the definition of primary melanomas of the salivary glands remains controversial. In this paper we describe an unusual case of primary melanoma arising in the parotid gland. A 60-year-old woman presented to us for the persistence of a parotid neoplasm diagnosed as carcinoma by fine-needle aspiration and treated with radiation therapy. Wide destructive surgery was performed and immunohistochemical analysis of the surgical specimen led to a diagnosis of melanoma. Complete screening excluded other primary tumor sites. After five years of follow-up the patient Is alive and free of disease. Here we report the diagnostic procedures leading to the diagnosis along with a critical analysis of the literature, emphasizing the difficulties in the diagnosis and classification of melanoma as a primary tumor in the parotid gland and the need for destructive surgery.
authors.affiliation: Second Otolaryngology Department, University of Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bussi
authors.forename: L
authors.initials: L
authors.lastname: Cardarelli
authors.forename: E
authors.initials: E
authors.lastname: Riontino
authors.forename: G
authors.initials: G
authors.lastname: Valente
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000473:pathology* / Q000601:surgery