Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora.
Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.
Xu
Y J
YJ
Department of Chemistry, National University of Singapore.
Wu
X H
XH
Tan
B K
BK
Lai
Y H
YH
Vittal
J J
JJ
Imiyabir
Z
Z
Madani
L
L
Khozirah
K S
KS
Goh
S H
SH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006575:Heterocyclic Compounds, 3-Ring / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D006575:Heterocyclic Compounds, 3-Ring