[Modeling of the two wave response of ATP receptors to jumps of the agonist concentration in pheochromocytoma cells].
A model for the kinetics of conformational transitions of ionotropic ATP receptors in pheochromocytoma cells was elaborated. The contribution of the states of ionotropic receptors (upon the blockage of the "open" channel state) to the kinetics of postsynaptic currents was estimated at mediator concentrations studied. The model enables one to determine the contribution of various conformational states of the receptor, in particular in the "closed" state, to the dynamics of ionic current that is registered upon stimulation of ATP receptors. It is shown that after the cessation of the agonist application, a secondary current wave can arise. The rate constants for conformational transitions of ATP receptors were determined.
Skorinkin
A I
AI
Laboratory of Biophysics, Kazan State University, Russia.
Giniatullin
R A
RA
D004305:Dose-Response Relationship, Drug; D015640:Ion Channel Gating; D007473:Ion Channels / Q000502:physiology; D007700:Kinetics; D008954:Models, Biological; D010673:Pheochromocytoma; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2 / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D014407:Tumor Cells, Cultured
D007473:Ion Channels; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2