The abasic site as a target for generation of locally multiply damaged sites.
Abasic sites in DNA have been specifically targeted by synthetic compounds able to cleave DNA at abasic sites and to induce photodamages in the vicinity of the lesion. The synthesis and the photoactivity of the drugs on abasic sites containing DNA and oligonucleotides are reported.
Martelli
A
A
LEDSS, Chimie Bioorganique, UMR CNRS 5616, Université Joseph Fourier, Grenoble, France.
Berthet
N
N
Constant
J F
JF
Demeunynck
M
M
Lhomme
J
J
D000970:Antineoplastic Agents / Q000494:pharmacology; D004247:DNA / Q000737:chemistry / Q000187:drug effects* / Q000528:radiation effects; D004249:DNA Damage; D010777:Photochemistry
D000970:Antineoplastic Agents; D004247:DNA