title: Successful Coronary Interventions Performed with Argatroban Anticoagulation in Patients with Heparin-Induced Thrombocytopenia and Thrombosis Syndrome.
abstract: Patients with heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) frequently have coincident vascular disease. Patients with HITTS who require vascular procedures have often been excluded from vascular intervention because intravascular procedures require heparin. Re-exposure to heparin places these patients at great risk for reactivation of thrombosis related to HIT antibody. We present our initial experience with an alternative anticoagulant to heparin, argatroban in patients with HIT antibody who underwent 14 coronary interventions. All 14 coronary lesions were treated successfully and no patient suffered an HITTS-related or an argatroban-related complication.
authors.affiliation: Loyola University Medical Center, 2160 South First Avenue, Maywood, IL, 60153, USA.
authors.initials: BE
authors.lastname: Lewis
authors.initials: JJ
authors.lastname: Ferguson
authors.initials: ED
authors.lastname: Grassman
authors.initials: J
authors.lastname: Fareed
authors.initials: J
authors.lastname: Walenga
authors.initials: JL
authors.lastname: Joffrion
authors.initials: L
authors.lastname: Wrona
authors.initials: SA
authors.lastname: Johnson
authors.initials: RP
authors.lastname: Schwarz
authors.initials: T
authors.lastname: McKiernan