Endocrine-disrupting chemicals: prepubertal exposures and effects on sexual maturation and thyroid activity in the female rat. A focus on the EDSTAC recommendations.
In 1996, the US Environmental Protection Agency was given a mandate by Congress to develop a screening program that would evaluate whether variously identified compounds could affect human health by mimicking or interfering with normal endocrine regulatory functions. Toward this end, the Agency chartered the Endocrine Disruptor Screening and Testing Advisory Committee in October of that year that would serve to recommend a series of in vitro and in vivo protocols designed to provide a comprehensive assessment of a chemical's potential endocrine-disrupting activity. A number of these protocols have undergone subsequent modification by EPA, and this review focuses specifically on the revised in vivo screening procedure recommended under the title Research Protocol for Assessment of Pubertal Development and Thyroid Function in Juvenile Female Rats. Background literature has been provided that summarizes what is currently known about pubertal development in the female rat and the influence of various forms of pharmaceutical and toxicological insult on this process and on thyroid activity. Finally, a section is included that discusses technical issues that should be considered if the specified pubertal endpoints are to be measured and successfully evaluated.
Goldman
J M
JM
Reproductive Toxicology Division, National Health & Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Laws
S C
SC
Balchak
S K
SK
Cooper
R L
RL
Kavlock
R J
RJ
D000818:Animals; D005260:Female; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D051381:Rats; D012015:Reference Standards; D012741:Sexual Maturation / Q000187:drug effects* / Q000502:physiology; D013959:Thyroid Diseases / Q000139:chemically induced*; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D018675:Toxicity Tests; D014481:United States; D014484:United States Environmental Protection Agency
D015386:Hazardous Substances