Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths.
We characterized evolutionarily conserved J domain containing protein (JDP) genes from human, Bombyx mori, and Manduca sexta. Each of the JDP proteins contains a J domain at its N-terminus and a highly conserved C-terminal domain. Southern blot analysis revealed that the human JDP1 gene is present as a single copy in the human genome. Expression was higher in brain, heart, and testis than in kidney or stomach. Human JDP1 was mapped in silico to chromosome 10q21.1, which exhibits a conserved synteny with the central region of mouse chromosome 10. Drosophila jdp is located at 99F4-99F11 on the right arm of the third chromosome.
Lee
J
J
Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon, South Korea.
Hahn
Y
Y
Yun
J H
JH
Mita
K
K
Chung
J H
JH
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D012831:Bombyx; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D019143:Evolution, Molecular; D020224:Expressed Sequence Tags; D006801:Humans; D008969:Molecular Sequence Data; D009036:Moths; D010802:Phylogeny; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment
C484558:DNAJC12 protein, human; C491387:JDP2 protein, human; C491386:Jundp2 protein, mouse; D012097:Repressor Proteins