title: Characterization of two divergent lineages of macaque rhadinoviruses related to Kaposi's sarcoma-associated herpesvirus.
abstract: We have cloned and characterized the entire DNA polymerase gene and flanking regions from Kaposi's sarcoma-associated herpesvirus (KSHV) and two closely related macaque homologs of KSHV, retroperitoneal fibromatosis-associated herpesvirus-Macaca nemestrina (RFHVMn) and -Macaca mulatta (RFHVMm). We have also identified and partially characterized the corresponding genomic region of another KSHV-like herpesvirus, provisionally named "M. nemestrina rhadinovirus type 2 (MneRV-2)," with close similarity to rhesus rhadinovirus (RRV). A sequence comparison of these four macaque viruses and two KSHV-like gammaherpesviruses recently identified in African green monkeys, Chlorocebus rhadinovirus types 1 and 2 (ChRV-1 and ChRV-2) reveals the presence of two distinct lineages of KSHV-like rhadinoviruses in Old World primates. The first rhadinovirus lineage consists of KSHV and its closely related homologs RFHVMn, RFHVMm, and ChRV-1, while the second more distantly related lineage consists of RRV, MneRV-2, and ChRV-2. Our findings raise the possibility of the existence of another human KSHV-like herpesvirus belonging to the second rhadinovirus lineage.
authors.affiliation: Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Schultz
authors.forename: G W
authors.initials: GW
authors.lastname: Rankin
authors.forename: M P
authors.initials: MP
authors.lastname: Blanc
authors.forename: B W
authors.initials: BW
authors.lastname: Raden
authors.forename: C C
authors.initials: CC
authors.lastname: Tsai
authors.forename: T M
authors.initials: TM
authors.lastname: Rose
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D018142:Gammaherpesvirinae / Q000145:classification / Q000235:genetics*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D008253:Macaca mulatta; D008254:Macaca nemestrina; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000821:virology; D016366:Open Reading Frames; D010802:Phylogeny; D012185:Retroperitoneal Fibrosis / Q000662:veterinary / Q000821:virology; D012514:Sarcoma, Kaposi / Q000821:virology; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D014759:Viral Envelope Proteins; D004259:DNA-Directed DNA Polymerase