Suitably functionalised pyrimidines as potential antimycotic agents.
Various suitably functionalized pyrimidine derivatives have been synthesized to explore their potential as antimycotic agents. Some of the synthesized compounds 4c, 4d, 8a-e have shown highly significant in vitro antifungal activity against five human pathogenic fungi.
Agarwal
N
N
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Raghuwanshi
S K
SK
Upadhyay
D N
DN
Shukla
P K
PK
Ram
V J
VJ
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000145:classification / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity
D000935:Antifungal Agents; D011743:Pyrimidines