nPKCdelta a new therapeutic marker for melanoma metastasis? (Review).
Melanoma metastasis is almost uniformly fatal. The identification of signal transduction as crucial effectors for tumorigenesis suggests modalities of gene therapy as well as design of specific drugs. the possible use of nPKCdelta as a therapeutic target is reviewed and discussed. Motivated by recent results, we propose a model in which nPKCdelta modulates melanin synthesis as well as metastasis.
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Department of General Physiology and Biochemistry, Section of General Pathology, University of Milan, I-20133 Milan, Italy.
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002678:Chimera; D005544:Forecasting; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D008545:Melanoma / Q000235:genetics / Q000378:metabolism* / Q000556:secondary*; D011237:Predictive Value of Tests; D011493:Protein Kinase C / Q000235:genetics / Q000378:metabolism*; D051745:Protein Kinase C-delta
D014408:Biomarkers, Tumor; D007527:Isoenzymes; C497258:PRKCD protein, human; D011493:Protein Kinase C; D051745:Protein Kinase C-delta