Role of eosinophils in the pathogenesis of Mycobacterium bovis BCG infection in gamma interferon receptor-deficient mice.
A profound eosinophil infiltration of granulomas is observed in the lungs of Mycobacterium bovis bacillus Calmette Guérin-infected gamma interferon receptor-deficient mice. Blockade of eosinophil proliferation and recruitment into the lung by treatment with anti-interleukin-5 monoclonal antibody marginally reduced mycobacterial growth within the lung but did not affect dissemination of the infection to other tissues.
Kirman
J
J
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington South, New Zealand.
Zakaria
Z
Z
McCoy
K
K
Delahunt
B
B
Le Gros
G
G
D000818:Animals; D004804:Eosinophils / Q000276:immunology*; D015769:Granuloma, Respiratory Tract / Q000276:immunology* / Q000473:pathology; D015848:Interleukin-5 / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D009163:Mycobacterium bovis / Q000276:immunology* / Q000472:pathogenicity; D017471:Receptors, Interferon / Q000235:genetics / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000473:pathology; D000096743:Interferon gamma Receptor
D015848:Interleukin-5; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor