Chlamydia pneumoniae in atherosclerosis.
Chlamydia pneumoniae is currently the infectious agent most often associated with the inflammation found in atherosclerosis. The seroepidemiological association and the actual presence of pathogen in lesions has been confirmed in numerous studies, in which technical difficulties seem to be the only limitation. Besides animal experiments and intervention trials, we need information of possible pathogenic mechanisms. Recently, several studies have suggested mechanisms by which C. pneumoniae infection could participate in the development of atherosclerosis.
Saikku
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KTL, National Public Health Institute, Department in Oulu, Oulu, Finland.
D000942:Antigens, Bacterial; D001161:Arteriosclerosis / Q000276:immunology / Q000382:microbiology*; D018834:Chaperonin 60 / Q000378:metabolism; D002690:Chlamydia Infections / Q000150:complications* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification; D004731:Endotoxins / Q000378:metabolism; D006801:Humans
D000942:Antigens, Bacterial; D018834:Chaperonin 60; D004731:Endotoxins