title: The interaction of benzimidazole compounds with DNA: intercalation and groove binding modes.
abstract: Benzimidazole compounds (Fig. 1) have been synthesized to study their DNA-binding properties. Results obtained with spectroscopy and viscosity measurements indicate that the binding mode varies from intercalation to groove-binding, depending on the number of benzimidazole rings (conformation and size of compounds).
authors.affiliation: Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Iwamoto
authors.forename: T
authors.initials: T
authors.lastname: Seki
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry*; D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D014783:Viscosity
chemical_list: D001562:Benzimidazoles; D007364:Intercalating Agents; D004247:DNA