Characterization of ferrochelatase (hemH) mutations in Haemophilus influenzae.
Haemophilus influenzae lacks most of the biosynthetic enzymes for hemin synthesis. However, the organism has retained ferrochelatase activity, which we identified to be encoded by a hemH-homologous gene. In this report we characterize the growth physiology conferred by hemH mutations under infection and laboratory conditions.
Schlör
S
S
Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany.
Herbert
M
M
Rodenburg
M
M
Blass
J
J
Reidl
J
J
D000818:Animals; D005294:Ferrochelatase / Q000235:genetics*; D006193:Haemophilus influenzae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D016296:Mutagenesis; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley
D005294:Ferrochelatase