Synthesis of 4'-thio-beta-D-arabinofuranosylcytosine (4'-thio-ara-C) and comparison of its anticancer activity with that of ara-C.
4'-thio-beta-D-arabinofuranosylcytosine was synthesized by a facile route in high yields. It was evaluated for antitumor activity against a panel of human tumors, both in vitro and in vivo.
Tiwari
K N
KN
Southern Research Institute, Birmingham, Alabama 35255-5305, USA.
Shortnacy-Fowler
A T
AT
Cappellacci
L
L
Parker
W B
WB
Waud
W R
WR
Montgomery
J A
JA
Secrist
J A
JA
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001087:Arabinonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003561:Cytarabine / Q000737:chemistry / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D004273:DNA, Neoplasm / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D008819:Mice, Nude; D010766:Phosphorylation; D014407:Tumor Cells, Cultured
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D001087:Arabinonucleosides; D004273:DNA, Neoplasm; D003561:Cytarabine; C411255:4'-thio-arabinofuranosylcytosine