Adapter proteins in lymphocyte antigen-receptor signaling.
Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.
Myung
P S
PS
Graduate Program of Immunology, University of Pennsylvania, The Leonard and Madlyn Abramson Family Cancer Research Institute, Philadelphia, PA 19104-6160, USA.
Boerthe
N J
NJ
Koretzky
G A
GA
D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D011506:Proteins / Q000378:metabolism*; D011946:Receptors, Antigen / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction
D011506:Proteins; D011946:Receptors, Antigen; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell