Correlation between placental bed biopsy findings, vascular cell adhesion molecule and fibronectin levels in pre-eclampsia.
OBJECTIVE
To determine the correlation between placental bed biopsy findings, and blood levels of the vascular cell adhesion molecule (VCAM-1) and fibronectin in pre-eclampsia/eclampsia, and to evaluate the relationship between these variables and severity of the disease.


METHODS
A prospective case-control study.


METHODS
Department of Obstetrics and Gynaecology, Cerrahpasa Medical Faculty, Istanbul.


METHODS
Thirty-five women with pre-eclampsia/eclampsia were compared with 25 healthy women with uncomplicated pregnancies. Twenty-one placental bed biopsies from pre-eclamptic pregnancies were compared with 17 from normal pregnancies.


METHODS
Peripheral venous blood levels of VCAM-1 and fibronectin, measured by enzyme-linked immunoassay and radial immune diffusion technique.


RESULTS
In pre-eclampsia/eclampsia, blood VCAM-1 and fibronectin levels were higher than in normal pregnancy. Levels of both fibronectin and VCAM-1 correlated significantly with the diastolic blood pressure (r = 0.49 and r = 0.65, P < 0.001). There was also a significant direct linear correlation between plasma fibronectin and VCAM-1 levels (r = 0.57, P < 0.001). Normotensive women all had normal placental bed biopsy findings and the incidence of pathological placental bed biopsy findings increased with the severity of the pre-eclampsia.


CONCLUSIONS
Inadequate trophoblastic invasion of spiral arteries, and elevated levels VCAM-1 and fibronectin were found in women with pre-eclampsia. The magnitude of defective trophoblastic invasion, and blood levels of VCAM-1 and fibronectin correlate with the clinical severity of pre-eclampsia.
Madazli
R
R
Department of Obstetrics and Gynaecology, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
Budak
E
E
Calay
Z
Z
Aksu
M F
MF
D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood / Q000473:pathology*; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D010920:Placenta / Q000473:pathology*; D011225:Pre-Eclampsia / Q000097:blood / Q000473:pathology*; D011247:Pregnancy; D011446:Prospective Studies; D014421:Turkey; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D005353:Fibronectins; D019010:Vascular Cell Adhesion Molecule-1