[The lipid composition characteristics of the blood serum and aortic wall in the modelling of different types of arteriosclerosis].
Executed was modelling of Mönckeberg's arteriosclerosis by injection into rabbits monoiodacetat, ergocalciferol; cholesterol atherosclerosis and combined type of lesion by simultaneous intake of cholesterol and monoiodacetat. Examined was the content of lipoproteins of different classes in blood serum, in aorta tissue--cholesterol, triglycerides, phospholipids. During all implemented ways of actions the change in comparative content of lipoproteins was indicated, what can be estimated as atherogenic. Monoiodacetat model of arteriosclerosis is accompanied with denominated accumulation of lipids in aorta walls, ergocalciferol model with accumulation of triglycerides only.
Larionova
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A. A. Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kiev.
D000818:Animals; D001011:Aorta / Q000737:chemistry / Q000378:metabolism*; D001161:Arteriosclerosis / Q000139:chemically induced / Q000378:metabolism*; D002784:Cholesterol; D004195:Disease Models, Animal; D004872:Ergocalciferols; D007461:Iodoacetates; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008074:Lipoproteins / Q000032:analysis / Q000378:metabolism; D011817:Rabbits; D013997:Time Factors
D004872:Ergocalciferols; D007461:Iodoacetates; D008055:Lipids; D008074:Lipoproteins; D002784:Cholesterol