title: Adapter proteins in lymphocyte antigen-receptor signaling.
abstract: Adapter molecules contain discrete modular domains that direct specific intermolecular interactions to orchestrate assembly of signaling complexes. A number of adapter proteins play critical roles in both positive and negative regulation of antigen-receptor signaling, influencing lymphocyte development and function.
authors.affiliation: Graduate Program of Immunology, University of Pennsylvania, The Leonard and Madlyn Abramson Family Cancer Research Institute, Philadelphia, PA 19104-6160, USA.
authors.forename: P S
authors.initials: PS
authors.lastname: Myung
authors.forename: N J
authors.initials: NJ
authors.lastname: Boerthe
authors.forename: G A
authors.initials: GA
authors.lastname: Koretzky
mesh_terms: D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D011506:Proteins / Q000378:metabolism*; D011946:Receptors, Antigen / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011506:Proteins; D011946:Receptors, Antigen; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell