title: Voxel similarity measures for 3-D serial MR brain image registration.
abstract: We have evaluated eight different similarity measures used for rigid body registration of serial magnetic resonance (MR) brain scans. To assess their accuracy we used 33 clinical three-dimensional (3-D) serial MR images, with deformable extradural tissue excluded by manual segmentation and simulated 3-D MR images with added intensity distortion. For each measure we determined the consistency of registration transformations for both sets of segmented and unsegmented data. We have shown that of the eight measures tested, the ones based on joint entropy produced the best consistency. In particular, these measures seemed to be least sensitive to the presence of extradural tissue. For these data the difference in accuracy of these joint entropy measures, with or without brain segmentation, was within the threshold of visually detectable change in the difference images.
authors.affiliation: Radiological Sciences and Medical Engineering, Guy's, King's and St Thomas' School of Medicine, King's College London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Holden
authors.forename: D L
authors.initials: DL
authors.lastname: Hill
authors.forename: E R
authors.initials: ER
authors.lastname: Denton
authors.forename: J M
authors.initials: JM
authors.lastname: Jarosz
authors.forename: T C
authors.initials: TC
authors.lastname: Cox
authors.forename: T
authors.initials: T
authors.lastname: Rohlfing
authors.forename: J
authors.initials: J
authors.lastname: Goodey
authors.forename: D J
authors.initials: DJ
authors.lastname: Hawkes
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*
chemical_list: D019382:Human Growth Hormone