The pharmacokinetics of ziprasidone in healthy volunteers treated with cimetidine or antacid.
OBJECTIVE
To evaluate the effects of cimetidine and Maalox(R) (aluminium hydroxide 1.35 g and magnesium hydroxide 1.2 g) on the pharmacokinetics of ziprasidone.


METHODS
Eleven healthy young subjects aged 18-45 years were given single oral doses of ziprasidone 40 mg on three occasions at least 7 days apart. On one occasion ziprasidone was administered alone, on another occasion ziprasidone was co-administered with oral cimetidine 800 mg and on a third occasion ziprasidone was co-administered with oral Maalox(R).


RESULTS
The administration of cimetidine increased the ziprasidone AUC(0,infinity) by 6% but there were no statistically significant differences in Cmax, tmax or lambda(z) between the ziprasidone+cimetidine group and the ziprasidone group. The administration of Maalox did not produce any statistically significant differences in AUC(0,infinity), Cmax, tmax or lambda(z) between the ziprasidone+Maalox group and the ziprasidone group.


CONCLUSIONS
The pharmacokinetics of ziprasidone are not affected by concurrent administration of cimetidine or Maalox. This suggests that other nonspecific inhibitors of cytochrome P450 and antacids are unlikely to alter the pharmacokinetics of ziprasidone.
Wilner
K D
KD
Department of Clinical Research, Pfizer Central Research, Groton, CT 06340, USA.
Hansen
R A
RA
Folger
C J
CJ
Geoffroy
P
P
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002927:Cimetidine / Q000494:pharmacology*; D018592:Cross-Over Studies; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D010879:Piperazines / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000493:pharmacokinetics*
D000863:Antacids; D000897:Anti-Ulcer Agents; D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone; D002927:Cimetidine