[Drug-induced gynecomastia].
Drugs are a very common cause of gynecomastia and should always be entertained as the possible causal agent of such a condition. This drug side-effect is due to an impaired balance in the serum estrogen/serum androgen ratio, whatever the mechanism, or a rise in prolactin level. Sex hormones, antiandrogens, are frequently involved as well as spironolactone, cimetidine, verapamil and cancer chemotherapy (especially alkylating agents). Diazepam, tricyclic antidepressants, neuroleptics, calcium channel blockers, captopril, digitalis glycosides, omeprazole, some antibiotics and growth hormone are all possibly, but less often, the responsible agent. Criteria of the French method for determining drug causality are discussed.
Hugues
F C
FC
Service de Médecine Interne II, Hôpital Laennec, Faculté de Médecine Necker-Enfants Malades, Paris.
Gourlot
C
C
Le Jeunne
C
C
D000726:Androgen Antagonists / Q000009:adverse effects; D000728:Androgens / Q000097:blood; D000970:Antineoplastic Agents / Q000009:adverse effects; D002317:Cardiovascular Agents / Q000009:adverse effects; D004967:Estrogens / Q000097:blood; D005765:Gastrointestinal Agents / Q000009:adverse effects; D012739:Gonadal Steroid Hormones / Q000009:adverse effects; D006177:Gynecomastia / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood; D011619:Psychotropic Drugs / Q000009:adverse effects
D000726:Androgen Antagonists; D000728:Androgens; D000970:Antineoplastic Agents; D002317:Cardiovascular Agents; D004967:Estrogens; D005765:Gastrointestinal Agents; D012739:Gonadal Steroid Hormones; D011619:Psychotropic Drugs; D011388:Prolactin