title: Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.
abstract: The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.
authors.affiliation: Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France. guillou@icsn.cnrs-gif.fr
authors.forename: C
authors.initials: C
authors.lastname: Guillou
authors.forename: A
authors.initials: A
authors.lastname: Mary
authors.forename: D Z
authors.initials: DZ
authors.lastname: Renko
authors.forename: E
authors.initials: E
authors.lastname: Gras
authors.forename: C
authors.initials: C
authors.lastname: Thal
mesh_terms: D000110:Acetylcholinesterase / Q000187:drug effects / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D015195:Drug Design; D005702:Galantamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D005702:Galantamine; D000110:Acetylcholinesterase