title: Bipartite scaphoid with proximal pole osteonecrosis in a patient with Holt-Oram syndrome.
abstract: The Holt-Oram syndrome features a spectrum of upper limb abnormalities, including an abnormal shape of the scaphoid. Our report concerns a 19-year-old man with Holt-Oram syndrome and flattening and sclerosis of the proximal pole of a bipartite scaphoid. The initial ossification centre in the scaphoid was located distally at 8 years of age. By age 13, a pair of ossific centres were present. After an automobile accident at age 18, the proximal pole became sclerotic and then began to fragment over a 22-month period. Computed tomography confirmed the presence of two poles of the scaphoid and sclerosis and fragmentation of the proximal pole.
authors.affiliation: 40202
authors.forename: D E
authors.initials: DE
authors.lastname: Tate
authors.forename: A
authors.initials: A
authors.lastname: Gupta
authors.forename: H E
authors.initials: HE
authors.lastname: Kleinert
mesh_terms: D000328:Adult; D002348:Carpal Bones / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000473:pathology; D006801:Humans; D008297:Male; D010020:Osteonecrosis / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D013577:Syndrome