Searching for significance in TCR-cytoskeleton interactions.
Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its zeta chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.
Caplan
S
S
Cell Biology and Metabolism Branch, Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-5430, USA.
Baniyash
M
M
D000818:Animals; D003599:Cytoskeleton / Q000276:immunology*; D015536:Down-Regulation; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; C054979:antigen T cell receptor, zeta chain