title: Regulation of T cell function by NK cell receptors for classical MHC class I molecules.
abstract: Inhibitory receptors for MHC class I molecules were initially characterised on NK cells. Human and mouse NK cell receptors (NKRs) are also expressed on T cells, predominantly on a subset of memory-phenotype CD8(+) T cells. This review focuses on the precise determination of interactions between NKRs and MHC class I, as well as on the unexpected in vivo function of NKRs on T cells.
authors.affiliation: Centre d'Immunologie de Marseille-Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Campus Universitaire de Luminy, Marseille, 13288, France.
authors.forename: S
authors.initials: S
authors.lastname: Ugolini
authors.forename: E
authors.initials: E
authors.lastname: Vivier
mesh_terms: D000818:Animals; D015703:Antigens, CD; D000950:Antigens, Ly; D018414:CD8-Positive T-Lymphocytes; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007156:Immunologic Memory; D007694:Killer Cells, Natural; D037181:Lectins, C-Type; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D011971:Receptors, Immunologic / Q000378:metabolism*; D054340:Receptors, KIR; D055630:Receptors, NK Cell Lectin-Like; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D000950:Antigens, Ly; D015395:Histocompatibility Antigens Class I; C105299:LILRB1 protein, human; D037181:Lectins, C-Type; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D055630:Receptors, NK Cell Lectin-Like