Synergistic effects of thearubigin and genistein on human prostate tumor cell (PC-3) growth via cell cycle arrest.
There is evidence that habitual consumption of green tea by Japanese men is correlated with a reduction in cancers, including prostate; soybean isoflavones are also associated with increased protection. The present study compared the anti-proliferative effect of black tea (Camellia sinensis) polyphenol, thearubigin (TR), alone or combined with the isoflavone genistein, on human prostate (PC-3) carcinoma cells. TR administered alone did not result in any alteration of cell growth. When combined with genistein, however, TR significantly inhibited cell growth and induced a G2/M phase cell cycle arrest in a dose dependent manner. These findings indicate the potential use of combined phytochemicals to provide protection against prostate cancer.
Sakamoto
K
K
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA. kxs94@po.cwru.edu
D016588:Anticarcinogenic Agents; D000975:Antioxidants / Q000633:toxicity*; D002392:Catechin / Q000031:analogs & derivatives* / Q000633:toxicity; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D004273:DNA, Neoplasm / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D019833:Genistein / Q000633:toxicity*; D006801:Humans; D007564:Japan; D008297:Male; D010636:Phenols / Q000633:toxicity*; D008517:Phytotherapy; D059808:Polyphenols; D011471:Prostatic Neoplasms; D013662:Tea / Q000627:therapeutic use; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D000975:Antioxidants; D004273:DNA, Neoplasm; D010636:Phenols; D059808:Polyphenols; D013662:Tea; C086701:thearubigin; D002392:Catechin; D019833:Genistein