Facile synthesis of O6-alkyl-, O6-aryl-, and diaminopurine nucleosides from 2'-deoxyguanosine
The 3',5'-bis-O-TBDMS derivative of 2'-deoxyguanosine can be converted to its O6-alkyl and O6-aryl ethers as well as to N6-substituted diaminopurine nucleosides in two simple steps. Also described is a novel, nonaqueous, one-step O6-desulfonylation method that leads to deprotection of the carbonyl moiety of 2'-deoxyguanosine.
Lakshman
MK
Department of Chemistry, University of North Dakota, Grand Forks 58202-9024, USA. mlakshman@mail.chem.und.nodak.edu
Ngassa
FN
Keeler
JC
Dinh
YQ
Hilmer
JH
Russon
LM