What should the clinician know about the cytochrome P450 system?
The cytochromes P450 are a superfamily of enzymes which catalyse mono-oxidation, thus transforming fat-soluble toxins into water-soluble metabolites which are excreted in urine. Cytochromes P450 are mainly located in the liver, they play a major role in hepatotoxicity. The toxins (or the drugs) can be in part transformed into reactive metabolites which destroy intrahepatocytic proteins (metabolite-related hepatotoxicity) or form an immune complex that induces immune reactions (immune-related hepatotoxicity).
Benhamou
J P
JP
Hôpital Beaujon, Clichy, France.
D000818:Animals; D001324:Autoantigens; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology; D003577:Cytochrome P-450 Enzyme System / Q000009:adverse effects / Q000276:immunology / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000201:enzymology; D015262:Xenobiotics / Q000378:metabolism
D001324:Autoantigens; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System