Neural electrophysiological effect of crude venom of conus textile from the south China Sea.
In the present study, we characterized effects of the crude venom from Conus textile, a marine molluscivorous snail collected from the South China Sea, on neural electrophysiological activity in insect, molluscan and mammalian species. Our results demonstrate that the venom reversibly blocks the cholinergic synaptic transmission of cockroach Periplaneta americana central nervous system, partially blocks Na(+) currents in rat hippocampal CA(1) pyramidal neurons, and enhances the excitability and spontaneous activity of the giant neurons of garden snail Achatina fulica.
Yang
D M
DM
National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, People's Republic of China.
Hu
K P
KP
Li
C Y
CY
Wu
C H
CH
Zhou
P A
PA
D000818:Animals; D003058:Cockroaches; D020916:Conotoxins / Q000633:toxicity*; D004558:Electric Stimulation; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D066298:In Vitro Techniques; D008974:Mollusca / Q000737:chemistry*; D008978:Mollusk Venoms / Q000737:chemistry* / Q000633:toxicity; D009474:Neurons / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012908:Snails; D009435:Synaptic Transmission / Q000187:drug effects*
D020916:Conotoxins; D008978:Mollusk Venoms