Clinical significance of tenascin-C expression in osteosarcoma: tenascin-C promotes distant metastases of osteosarcoma.
Tenascin-C (TN-C) is one of extracellular matrix glycoproteins. We have immunohistochemically examined the TN-C expression of 33 primary osteosarcoma paraffin-embedded samples. The TN-C expression of the patient group with metastases was higher than that of the group without metastases at significant difference, and the survival curves show a tendency for poor outcome in the high grade staining group. Moreover, the supplemental TN-C had an effect of easier migration of a human osteosarcoma cell line (HOS) in vitro. The results may suggest that TN-C help osteosarcoma cells to migrate and to metastasize.
Tanaka
M
M
Department of Orthopaedic Surgery, Mie University faculty of Medicine, Tsu, Mie 514-8507, Japan.
Yamazaki
T
T
Araki
N
N
Yoshikawa
H
H
Yoshida
T
T
Sakakura
T
T
Uchida
A
A
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D002455:Cell Division; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D011237:Predictive Value of Tests; D015996:Survival Rate; D019063:Tenascin / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D019063:Tenascin