title: Novel practical synthesis of Kdn2en and its C-4 nitrogen-modified derivatives.
abstract: A practical synthesis of Kdn2en and 4-amino-4-deoxy-Kdn2en has been achieved via a key intermediate, methyl 4,5,7,8,9-penta-O-acetyl-2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2- enonate, which has been prepared from Kdn in three steps in 91% overall yield.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
authors.forename: X L
authors.initials: XL
authors.lastname: Sun
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Kai
authors.forename: K
authors.initials: K
authors.lastname: Furuhata
mesh_terms: D002845:Chromatography; D004952:Esters / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D009584:Nitrogen / Q000737:chemistry*; D012794:Sialic Acids / Q000138:chemical synthesis*; D013696:Temperature
chemical_list: C105090:2-deoxy-2,3-didehydro-D-glycero-D-galacto-2-nonulopyranosonic acid; D004952:Esters; D012794:Sialic Acids; D009584:Nitrogen