[Bronchial reactivity as factor of effectiveness of new antiasthmatic drugs].
OBJECTIVE
To evaluate bekotid and bekodisk effects on bronchial reactivity and sensitivity.


METHODS
Bronchial reactivity and sensitivity were studied in a comparative study of two corticosteroids for inhalation--bekotid and bekodisk--in 37 patients with bronchial asthma. Unlike bekotid, bekodisk does not contain freon which irritates mucosa of the upper respiratory tracts and bronchi. The examination included clinical and allergological tests, provocative inhalation tests, peak flowmetry, assessment of bronchial resistance and external respiration function.


RESULTS
Bekodisk treatment reduced the number of asphyxia episodes, sensitivity to carbacholine, the need in inhalation sympathomimetics, improved external respiration function.


CONCLUSIONS
Determination of reactivity and sensitivity of the bronchi is essential for comparison of drugs against bronchial asthma. Bekodisk significantly lowers reactivity to nonspecific mediatory substances, is simple and available in application, is more tolerable than bekotid.
Pol'ner
S A
SA
Chervinskaia
T A
TA
D000280:Administration, Inhalation; D000403:Airway Resistance / Q000187:drug effects*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D001999:Bronchoscopy; D002217:Carbachol / Q000008:administration & dosage; D018679:Cholinergic Agonists / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D006889:Hydroxycorticosteroids; D008297:Male; D016896:Treatment Outcome
D018927:Anti-Asthmatic Agents; D018679:Cholinergic Agonists; D005938:Glucocorticoids; D006889:Hydroxycorticosteroids; D002217:Carbachol; D001507:Beclomethasone