Atypical solitary fibrous tumor of the vulva.
An atypical solitary fibrous tumor (SFT) was encountered as a slow-growing, 15-cm, well-demarcated, vulvar tumor in a 70-year-old woman. The tumor was highly cellular and composed predominantly of hemangiopericytomatous and capillary hemangioma-like proliferations and short fascicular arrangements of spindled cells. Multinucleated giant cells and tumor necrosis also were present. The tumor cells were positive for vimentin, CD34, progesterone receptors, and bcl-2 and were diploid by flow cytometry. The patient was well without disease 9 months after surgery. Awareness of the occurrence of atypical SFT in the vulva is important so that confusion with other neoplasms can be avoided.
Fukunaga
M
M
Department of Pathology, Jikei University School of Medicine, Tokyo, Japan.
D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D004247:DNA / Q000032:analysis; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
D018952:Antigens, CD34; D019253:Proto-Oncogene Proteins c-bcl-2; D011980:Receptors, Progesterone; D014746:Vimentin; D004247:DNA