title: New lanostanoids of Ganoderma tsugae.
abstract: Three new compounds, (24R, S)-3alpha-acetoxy-24-hydroxy-5alpha-lanosta-8,25-di en-21-oic acid, named tsugaric acid C (1); 3alpha-acetoxy-5alpha-lanosta-8, 24-diene-21-O-beta-D-xyloside, named tsugarioside B (2); and 3alpha-acetoxy-(Z)-24-methyl-5alpha-lanosta-8,23,25-tr ien-21-oic acid ester beta-D-xyloside, named tsugarioside C (3), and a mixture of two known steroids were isolated from the fruit bodies of Ganoderma tsugae. The structures of 1-3 were determined by spectral and chemical methods. The cytotoxic activity of the lanostanoid constituents of this fungus was evaluated against several different cancer cell lines.
authors.affiliation: School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
authors.forename: H J
authors.initials: HJ
authors.lastname: Su
authors.forename: Y F
authors.initials: YF
authors.lastname: Fann
authors.forename: M I
authors.initials: MI
authors.lastname: Chung
authors.forename: S J
authors.initials: SJ
authors.lastname: Won
authors.forename: C N
authors.initials: CN
authors.lastname: Lin
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D020940:Reishi; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D004365:Drugs, Chinese Herbal; C409622:tsugaric acid; C409623:tsugarioside B; C409613:tsugarioside C; D007810:Lanosterol