title: Systemic phaeohyphomycosis in pregnancy and the puerperium.
abstract: Systemic fungal infections are rare. In pregnancy, treatment is problematic because of the risk of possible teratogenic effects of the antifungal drugs. We present the case of a 32 year-old woman who presented during pregnancy with a two-month history of painless subcutaneous nodules. Excision biopsy of one lesion showed dematiaceous fungal elements. Anti-fungal treatment was deferred and the pregnancy proceeded uneventfully. The remaining nodules were excised at the time of caesarean section delivery. Three weeks into the puerperium, she developed generalised seizures and investigations indicated systemic fungal infection with positive cultures for Aureobasidium spp which responded to appropriate antifungal therapy of flucytosine and itraconazole.
authors.affiliation: Department of Child Health, University of the West Indies, Kingston, Jamaica.
authors.forename: H
authors.initials: H
authors.lastname: Fletcher
authors.forename: N P
authors.initials: NP
authors.lastname: Williams
authors.forename: A
authors.initials: A
authors.lastname: Nicholson
authors.forename: L
authors.initials: L
authors.lastname: Rainford
authors.forename: H
authors.initials: H
authors.lastname: Phillip
authors.forename: A
authors.initials: A
authors.lastname: East-Innis
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001203:Ascomycota / Q000302:isolation & purification*; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis* / Q000188:drug therapy; D011645:Puerperal Infection / Q000175:diagnosis* / Q000188:drug therapy; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D005437:Flucytosine