title: Tumor formation suppressed in gammadeltaT knock-out mice.
abstract: Tumor formation was examined in mice in which the beta-chain gene of alphabetaT was knocked out (alphabetaT-KO mice) or the delta-chain gene of gammadeltaT was knocked out (gammadeltaT-KO mice). Development of Hepa 1-6 cell hepatoma was observed in six of six alphabetaT-KO mice, in four of six wild-type mice, and in only one of six gammadeltaT-KO mice. These results imply that gammadeltaT cells play a role in suppression of killer cell activity in tumor-bearing mice.
authors.affiliation: RIKEN Cell Bank, RIKEN (The Institute of Physical and Chemical Research), 3-1-1 Koyadai, Tsukuba Science City, Ibaraki, Japan.
authors.forename: B N
authors.initials: BN
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Kohyama
authors.forename: K
authors.initials: K
authors.lastname: Saijo
authors.forename: M
authors.initials: M
authors.lastname: Kusakabe
authors.forename: T
authors.initials: T
authors.lastname: Ohno
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009368:Neoplasm Transplantation; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014407:Tumor Cells, Cultured
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta