Toll-like receptors.
Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria. Differential expression and regulation as well as distinct though overlapping ligand recognition patterns may underlie the existence of a vast TLR family. Apparent structural and functional redundancy may render certain outputs of the TLR family robust.
Muzio
M
M
Department of Immunology and Cell Biology, Mario Negri Institute, via Eritrea 62, 2015, Milan, Italy.
Mantovani
A
A
D000818:Animals; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D008562:Membrane Glycoproteins / Q000145:classification / Q000502:physiology*; D010802:Phylogeny; D011956:Receptors, Cell Surface / Q000145:classification / Q000502:physiology*; D015398:Signal Transduction; D013045:Species Specificity; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008024:Ligands; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors