Regulation of B cell function by linker proteins.
Studies over the past few years have demonstrated the importance of linker or adaptor proteins in the signaling pathways activated by the B cell antigen-receptor. These proteins direct the appropriate subcellular localization of enzymatic complexes, amplify signaling pathways and integrate the functions of distinct signaling complexes. Many of the recently identified linker proteins function through these distinct mechanisms to upregulate the BCR signaling pathway. In addition, linker proteins facilitate the influences of co-receptors that augment or dampen the BCR signaling pathway.
Kelly
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Department of Pediatrics, Medicine and Pathology, Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8022, Saint Louis, MO 63110, USA.
Chan
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D001402:B-Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*; D015290:Second Messenger Systems
D011506:Proteins; D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases