Persistent central diabetes insipidus presenting in a very low birth weight infant successfully managed with intranasal dDAVP.
We report a case of a premature very low birth weight infant who presented shortly after birth with idiopathic central diabetes insipidus that persisted beyond the neonatal period and has been successfully managed with intranasal 1-desamino-8-D-arginine vasopressin. Although this condition is rare in neonates, early recognition, evaluation, and therapy may prevent more severe morbidity. Long-term successful management resulting in normal growth and development during infancy can be achieved with intranasal 1-desamino-8-D-arginine vasopressin therapy.
Stapleton
G
G
Wilford Hall U.S. Air Force Medical Center, Lackland Air Force Base, San Antonio, TX 78236, USA.
DiGeronimo
R J
RJ
D000281:Administration, Intranasal; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage*; D003919:Diabetes Insipidus / Q000151:congenital / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D019102:Infant, Very Low Birth Weight; D008297:Male; D012076:Renal Agents / Q000008:administration & dosage*
D012076:Renal Agents; D003894:Deamino Arginine Vasopressin