Fragile X syndrome.
Fragile X syndrome is the most common form of inherited mental retardation. It is seen in people of all nationalities and in all areas of the world. Fragile X syndrome can be a devastating condition, as many boys are severely retarded and require multiple services. Treatment involves behaviour management techniques, appropriate school placement, community support for the family, and careful medical follow-up often including psychopharmacology. The genetics of fragile X syndrome is now understood, prenatal testing is available, and the disorder is preventable through appropriate genetic counselling. This review focuses on the neurobiology of fragile X syndrome, its clinical features and treatment.
Phillips
J P
JP
Department of Neurology, Indiana University Medical Centre, Indianapolis.
Wilson
G A
GA
D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005600:Fragile X Syndrome / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D010348:Patient Care Team; D010375:Pedigree; D010641:Phenotype