title: Influence of cyclosporin A on radiological progression in early rheumatoid arthritis patients: a 42-month prospective study.
abstract: The aim of this study was to evaluate whether cyclosporin A (CsA) influences the radiological disease progression in early rheumatoid arthritis (RA) patients in comparison with other disease-modifying drugs (DMARDs). A total of 103 early RA patients, without prior use of DMARDs, were randomized to receive CsA (3 mg/kg per day) or methotrexate (MTX) (0.15 mg/kg per week). In addition, all patients received prednisone (7.5 mg/day). After 42 months of treatment, pairs of hand and wrist radiographs of 41 patients treated with CsA and 42 treated with MTX were evaluated blindly and separately by two investigators, using reference radiographs for scoring. A scale scoring similar to Larsen's standard radiographs with minor modifications was used. The studied radiographs were obtained at the beginning and 42 months after therapy in both groups. Patients in both groups responded beneficially to the above treatment regimens. In the CsA group, 37 patients (71 %) remained radiographically stable and 4 worsened, while in the MTX group 39 patients (76%) remained stable and 3 deteriorated. No significant radiological worsening was found in the CsA-treated patients as compared to those treated with MTX. Early immuno-intervention in RA patients appears to be crucial for the future development of joint damage: CsA can delay radiological disease progression and may inhibit joint damage deterioration in early RA patients.
authors.affiliation: Department of Internal Medicine, Medical School, University of Ioannina, Greece.
authors.forename: A A
authors.initials: AA
authors.lastname: Drosos
authors.forename: P V
authors.initials: PV
authors.lastname: Voulgari
authors.forename: A
authors.initials: A
authors.lastname: Katsaraki
authors.forename: A K
authors.initials: AK
authors.lastname: Zikou
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D011446:Prospective Studies; D011859:Radiography; D013997:Time Factors; D014953:Wrist / Q000000981:diagnostic imaging
chemical_list: D018501:Antirheumatic Agents; D016572:Cyclosporine; D008727:Methotrexate