Immunoglobulin G3 antibodies specific for the 19-kilodalton carboxyl-terminal fragment of Plasmodium yoelii merozoite surface protein 1 transfer protection to mice deficient in Fc-gammaRI receptors.
Merozoite surface protein 1 (MSP-1(19)) is a leading malaria vaccine candidate. Specific antibodies contribute to immunity; binding to macrophages is believed to represent the main action of malaria antibodies. We show that an MSP-1(19)-specific immunoglobulin G3 (IgG3) monoclonal antibody can passively transfer protection to mice deficient in the alpha chain of Fc-gammaRI whose macrophages cannot bind IgG3.
Vukovic
P
P
The Cooperative Research Centre for Vaccine Technology, The Queensland Institute of Medical Research and the Australian Centre for International and Tropical Health and Nutrition, The University of Queensland, Brisbane 4029, Australia.
Hogarth
P M
PM
Barnes
N
N
Kaslow
D C
DC
Good
M F
MF
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000913:Antibodies, Protozoan / Q000276:immunology*; D000918:Antibody Specificity; D007116:Immunization, Passive / Q000379:methods; D007074:Immunoglobulin G / Q000276:immunology*; D008288:Malaria / Q000517:prevention & control*; D020066:Merozoite Surface Protein 1 / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010446:Peptide Fragments / Q000276:immunology; D010967:Plasmodium yoelii / Q000276:immunology*; D017452:Receptors, IgG / Q000235:genetics / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D020066:Merozoite Surface Protein 1; D010446:Peptide Fragments; D017452:Receptors, IgG