Chemical characterization and biological activity of Macfadyena unguis-cati (Bignoniaceae).
Macfadyena unguis-cati (L.) has been widely used in folk medicine as an anti-inflammatory, antimalarial and antivenereal. The purpose of this study was to chemically characterize the main plant components, and to evaluate the biological properties of some of the fractions derived from leaves (MACb) and liana (MACa) of this plant. Chemical characterization allowed the identification of the compounds corymboside, vicenin-2, quercitrin, chlorogenic acid, isochlorogenic acid, lupeol, beta-sitosterol, beta-sitosterylglucoside, allantoin and lapachol. The biological screening of fractions and/or purified substances derived from fractions revealed antitumoral and antitrypanosomal activities in fractions MACa/lapachol and MACb/MACb21, respectively. The anti-lipoxygenase and anti-cyclooxygenase effect seen in fractions MACa and MACb showed a partial correlation with the anti-inflammatory property attributed to this plant.
Duarte
D S
DS
Departamento de Física/Química, CECET, UNIVALE, Brasil.
Dolabela
M F
MF
Salas
C E
CE
Raslan
D S
DS
Oliveiras
A B
AB
Nenninger
A
A
Wiedemann
B
B
Wagner
H
H
Lombardi
J
J
Lopes
M T
MT
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001156:Artemia; D001681:Biological Assay; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016859:Lipoxygenase Inhibitors; D010063:Ovum / Q000166:cytology / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D010941:Plant Tumors / Q000382:microbiology; D010946:Plants, Medicinal / Q000737:chemistry*; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects / Q000378:metabolism; D012756:Sheep; D011198:Solanum tuberosum / Q000187:drug effects / Q000382:microbiology; D013552:Swine; D014344:Trypanocidal Agents / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts; D014344:Trypanocidal Agents; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases