[A trial of using timentin (ticarcillin/clavulanate) in treating abdominal surgical infection].
Efficacy of timentin was studied in the treatment of 19 patients with peritonitis of various etiology and clinical and laboratory signs of systemic inflammatory reaction characteristic of abdominal sepsis. The clinical and bacteriological effects were recorded in 84.2 and 87.5 per cent of the cases respectively. The drug was administered intravenously dropwise for 30 minutes in a dose of 3.1 g every 4 hours. The treatment course was 4-11 days. The treatment failed in 3 patients. One of them had general peritonitis of gynecological etiology. In the other no significant regression of abdominal sepsis was observed, Pseudomonas aeruginosa strains were isolated from the abdominal cavity, the antibiotic was changed, still incurable polyorganic insufficiency developed and the patient died. The third patient had perforation of the large intestine due to tumor. No adverse reactions to the use of timentin in any of the cases was observed.
Gel'fand
E B
EB
Russian State Medical University, Moscow.
Karabak
V I
VI
Platova
E S
ES
Gel'fand
B R
BR
D018806:APACHE; D000328:Adult; D000368:Aged; D002969:Clavulanic Acids / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D018805:Sepsis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013982:Ticarcillin / Q000008:administration & dosage / Q000009:adverse effects; D013997:Time Factors
D002969:Clavulanic Acids; C043215:ticarcillin-clavulanic acid; D013982:Ticarcillin