Pure red cell aplasia in a patient with chronic granulocytic leukaemia treated with interferon-alpha.
Interferon-alpha has been shown to improve survival in patients with chronic granulocytic leukaemia, therefore it is increasingly becoming part of the standard treatment of this condition. Interferon has a wide variety of side-effects. Pure red cell aplasia has been reported in a few cases of chronic granulocytic leukaemia but this usually heralds the onset of the transformation to the acute phase. This paper reports a possible, and not previously reported, side-effect of interferon-alpha in a patient with chronic granulocytic leukaemia.
Hirri
H M
HM
Haematology Department, Central Laboratory, St Mary's Hospital, Portsmouth, UK. Hussain.Hirri@smail01.porthosp.swest.nhs.uk
Green
P J
PJ
D000368:Aged; D000740:Anemia / Q000139:chemically induced; D001803:Blood Transfusion; D001853:Bone Marrow / Q000473:pathology; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage / Q000009:adverse effects; D016898:Interferon-alpha / Q000008:administration & dosage*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000235:genetics / Q000628:therapy*; D008297:Male; D010677:Philadelphia Chromosome; D012010:Red-Cell Aplasia, Pure / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013163:Splenomegaly / Q000628:therapy
D016898:Interferon-alpha; D006918:Hydroxyurea