title: Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats.
abstract: Pesticide chemicals may induce oxidative stress leading to generation of free radicals and alterations in antioxidants or oxygen free radical (OFR) scavenging enzymes. Hence, the effect of subchronic malathion (O,O-dimethyl-S-1,2, bis ethoxy carbonyl ethyl phosphorodithioate) exposure was evaluated on lipid peroxidation, glutathione and related enzymes and OFR scavenging enzymes in albino rats. Administration of malathion (20 ppm) for 4 weeks increased the malondialdehyde (MDA) levels in serum, activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in erythrocytes and glutathione reductase (GR) and glutathione S-transferase (GST) in serum. However, it decreased the glutathione (GSH) level in whole blood. Concomitant dietary feeding of Zingiber officinales Rosc (ginger 1%, w/w) significantly attenuated malathion induced lipid peroxidation and oxidative stress in these rats. These results indicate the possible involvement of free radicals in organophosphate-induced toxicity and highlight the protective action of ginger, an indigenous medicinal plant product.
authors.affiliation: Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, University of Delhi, Shahdara, Delhi, India.
authors.forename: R S
authors.initials: RS
authors.lastname: Ahmed
authors.forename: V
authors.initials: V
authors.lastname: Seth
authors.forename: S T
authors.initials: ST
authors.lastname: Pasha
authors.forename: B D
authors.initials: BD
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D004032:Diet; D005609:Free Radicals / Q000097:blood; D020939:Zingiber officinale; D005978:Glutathione / Q000378:metabolism; D007306:Insecticides / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008294:Malathion / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D005609:Free Radicals; D007306:Insecticides; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione; D008294:Malathion