The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors.
The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TRalpha 1 reduced them, whereas deletion of TRbeta actually increased them. These results could not be attributed to altered levels of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.
Dellovade
T L
TL
Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, New York 10021, USA.
Chan
J
J
Vennstrom
B
B
Forrest
D
D
Pfaff
D W
DW
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology; D004967:Estrogens / Q000097:blood / Q000494:pharmacology*; D005260:Female; D017353:Gene Deletion; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D009929:Organ Size / Q000187:drug effects; D010121:Oxytocin / Q000032:analysis; D010286:Paraventricular Hypothalamic Nucleus / Q000737:chemistry / Q000166:cytology; D011187:Posture; D011301:Preoptic Area / Q000737:chemistry / Q000166:cytology; D011374:Progesterone / Q000494:pharmacology; D011960:Receptors, Estrogen / Q000032:analysis; D011988:Receptors, Thyroid Hormone / Q000235:genetics* / Q000502:physiology*; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014599:Uterus / Q000187:drug effects / Q000254:growth & development; D014667:Vasopressins / Q000032:analysis
D004967:Estrogens; D011960:Receptors, Estrogen; D011988:Receptors, Thyroid Hormone; D014284:Triiodothyronine; D014667:Vasopressins; C074283:estradiol 3-benzoate; D011374:Progesterone; D004958:Estradiol; D010121:Oxytocin; D013974:Thyroxine