Beta-adrenoceptor inhibition for induction of acute cardiac failure in pigs.
For the testing of heart assist devices most animal models of acute cardiac failure that are usually used show certain disadvantages. We therefore developed a new method using the beta-adrenoceptor antagonist carazolol. We administered a bolus injection of 1 mg/kg followed by a continuous infusion of 1 mg/kg/h in adult German 'Landrasse' pigs. Blood pressure, heart rate, cardiac output and maximum left ventricular pressure rise time showed a significant (P < 0.05) reduction of the control value varying between 40% and 59%. The method is suitable for the testing of surgical approaches in heart failure.
Petzold
T
T
Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-Universität Düsseldorf, Germany.
Feindt
P
P
Menger
M D
MD
Gams
E
E
D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D011412:Propanolamines / Q000633:toxicity*; D013552:Swine
D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C014382:carazolol