[The effect of the new Russian concentrate of n-3 polyunsaturated fatty acids epaden on thrombocyte functional activity in vitro].
Epaden, the new domestic concentrate of n-3 polyunsaturated fatty acids (PUFA), is capable of inhibiting in vitro the human thrombocyte aggregation induced by ADP, collagen, and thrombin. It was established that the effect can hardly be related to the action of cyclooxygenase metabolites of eicosapentadienoic acid (entering into the epaden composition). The activity of epaden is probably explained by the effect of lipoxygenase metabolites of the n-3 polyunsaturated fatty acids or by the ligand properties of polyene acids entering into epaden. In addition, epaden is capable of reducing the release of thrombocyte factor 4 and tissue type plasminogen activator inhibitor from activated thrombocytes.
Kalugin
S A
SA
Laboratory of Hemostasis Pathology and Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Petrukhina
G N
GN
Makarov
V A
VA
Gandel'
V G
VG
D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D015539:Platelet Activation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013997:Time Factors
D015525:Fatty Acids, Omega-3; D010975:Platelet Aggregation Inhibitors; C408245:epaden