title: Other smoking-affected pulmonary diseases.
abstract: Cigarette smoking is the leading cause of preventable death in the United States. Smoking adversely affects many organ systems, but especially the lung. Carcinoma of the lung and chronic obstructive pulmonary disease account for most smoking-associated respiratory morbidity and mortality, and their association with smoking is both well established and widely recognized. Cigarette smoking also is associated with differences in the incidence, severity, or natural history of a broad array of other respiratory illnesses, ranging from the common cold to pneumothorax, pulmonary hemorrhage, and various interstitial lung diseases. Interestingly, while the general effect of smoking on respiratory diseases is adverse, in the cases of sarcoidosis and hypersensitivity pneumonitis smoking may actually be associated with a decrease in the incidence of disease. In this article, the author briefly discusses some of the pulmonary and systemic effects of smoking that might mediate its effects on an array of lung diseases, then comprehensively reviews less common or less well-recognized smoking-affected lung diseases such as pulmonary infections, spontaneous pneumothorax, Goodpasture's syndrome, eosinophilic granuloma and other interstitial lung diseases, and pulmonary metastatic disease.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California at Davis, School of Medicine, USA. Sxmurin@ucdavis.edu
authors.forename: S
authors.initials: S
authors.lastname: Murin
authors.forename: K S
authors.initials: KS
authors.lastname: Bilello
authors.forename: R
authors.initials: R
authors.lastname: Matthay
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000542:Alveolitis, Extrinsic Allergic / Q000276:immunology; D000998:Antiviral Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000503:physiopathology; D001195:Asbestosis / Q000209:etiology / Q000503:physiopathology; D001988:Bronchiolitis / Q000209:etiology / Q000503:physiopathology; D002644:Chickenpox / Q000188:drug therapy / Q000209:etiology; D004803:Eosinophilic Granuloma / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008171:Lung Diseases / Q000209:etiology* / Q000503:physiopathology; D008175:Lung Neoplasms / Q000209:etiology / Q000556:secondary; D018410:Pneumonia, Bacterial / Q000503:physiopathology; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000209:etiology; D011030:Pneumothorax / Q000209:etiology; D011658:Pulmonary Fibrosis / Q000209:etiology / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects* / Q000503:physiopathology
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir