Confidence bands for comparison of transition probabilities in a Markov chain model.
We consider graphs, confidence procedures and tests that can be used to compare transition probabilities in a Markov chain model with intensities specified by a Cox proportional hazard model. Under assumptions of this model, the regression coefficients provide information about the relative risks of covariates in one-step transitions, however, they cannot in general be used to to assess whether or not the covariates have a beneficial or detrimental effect on the endpoint events. To alleviate this problem, we consider graphical tests based on confidence procedures for a generalized Q-Q plot and for the difference between transition probabilities. The procedures are illustrated using data of the International Bone Marrow Transplant Registry.
Dabrowska
D M
DM
Department of Biostatistics, University of California, Los Angeles 90095-1772, USA. dorota@mozart.ph.ucla.edu
Ho
W T
WT
D016026:Bone Marrow Transplantation / Q000009:adverse effects; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000401:mortality / Q000628:therapy; D008390:Markov Chains; D009010:Monte Carlo Method; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012306:Risk; D016019:Survival Analysis