title: Detection of ventricular enlargement in patients at the earliest clinical stage of MS.
abstract: The aim of this study was to determine whether atrophy could be detected at the earliest clinical stages of MS. Patients were selected from a 1-year follow-up MRI study of clinically isolated syndromes. Nine patients who developed MS were compared with eight matched patients who had no further symptoms. Significant ventricular enlargement occurred in the group that developed MS but not in the other group. Our findings show that atrophy, albeit mild, can be detected early in the course of MS.
authors.affiliation: NMR Research Unit, Institute of Neurology, University College London, London, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Brex
authors.forename: R
authors.initials: R
authors.lastname: Jenkins
authors.forename: N C
authors.initials: NC
authors.lastname: Fox
authors.forename: W R
authors.initials: WR
authors.lastname: Crum
authors.forename: J I
authors.initials: JI
authors.lastname: O'Riordan
authors.forename: G T
authors.initials: GT
authors.lastname: Plant
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D002552:Cerebral Ventricles / Q000473:pathology*; D014695:Cerebral Ventriculography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results