[Adhesion molecules LFA-1(CD-11a), Mac-1(CD-11b) of t-lymphocytes in bronchoalveolar lavage fluid and blood in patients with chronic respiratory tract disease].
Adhesion molecules play an important role in inflammatory processes and influence on recruitment of effector cells. The aim of our study was to assess the percentage of T-lymphocytes expressing LFA-1, Mac-1 and ICAM-1 in bronchoalveolar fluid (BALF) and blood of patients with sarcoidosis, atopic bronchial asthma and chronic bronchitis. The reference group consisted of patients with haemoptysis or suspected of having bronchial carcinoma. Expression of adhesion molecules was revealed by /APAAP/ alkaline phosphatase anti alkaline phosphatase method. The highest percentage of lymphocytes expressing all adhesions molecules in BALF and blood was observed in patients with chronic bronchitis. Reductions of T-cells in BALF of patients with bronchial asthma and sarcoidosis may reflect of their direct binding in inflammatory sites. This studies confirm the involvement of adhesion molecules in maintenance of chronic inflammatory processes in the respiratory tract.
Chciałowski
A
A
Kliniki Chorób Wewnetrznych, Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej, Centralnego Szpitala Klinicznego Wojskowej Akademii Medycznej w Warszawie.
Lubiński
W
W
Płusa
T
T
Pirozyńska
E
E
Dudko
S
S
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D001999:Bronchoscopy / Q000379:methods; D002908:Chronic Disease; D005260:Female; D006801:Humans; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D016177:Macrophage-1 Antigen / Q000378:metabolism*; D008297:Male; D012140:Respiratory Tract Diseases / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism*
D015703:Antigens, CD; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen