Field responses to perforant path stimulation in the rat dentate gyrus: role of corticosterone and NMDA-receptor activation.
Recent studies showed that corticosterone and NMDA receptor activation suppress cell turn-over in the dentate gyrus through a common pathway, the NMDA receptor acting downstream of the corticosteroids. The present data show that in the absence of corticosteroids but not of NMDA receptor activation synaptic responses of dentate cells are reduced. The reduced synaptic responsiveness in the absence of corticosterone is therefore probably not caused by changes in cell turn-over.
Stienstra
C M
CM
Inst. Neurobiology, University of Amsterdam, The Netherlands.
van Diepen
M T
MT
Joëls
M
M
D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000502:physiology*; D018891:Dentate Gyrus / Q000502:physiology*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004558:Electric Stimulation; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D008297:Male; D019580:Perforant Pathway / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D003345:Corticosterone