title: Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry.
abstract: The overall history and recent advances in surface enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) technology is reviewed herein. Fundamentals of SELDI-TOF analysis are presented while drawing comparisons with other laser-based mass spectrometry techniques. The application of SELDI-TOF-MS to functional genomics and biomarker discovery is discussed and exemplified by elucidating a biomarker candidate for prostatic carcinoma. Finally, a short discussion regarding future SELDI requirements and developments is supplied.
authors.affiliation: Ciphergen Biosystems, Inc., Palo Alto, CA 94306, USA.
authors.forename: M
authors.initials: M
authors.lastname: Merchant
authors.forename: S R
authors.initials: SR
authors.lastname: Weinberger
mesh_terms: D006801:Humans; D011506:Proteins / Q000032:analysis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*
chemical_list: D011506:Proteins