Pretreatment with MK-801 or the lazaroid U-83836E does not enhance striatal graft survival.
A large proportion of grafted striatal neurons die, and mechanisms by which they succumb may involve excitotoxicity and oxidative stress. We investigated the effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate (MK-801) and lipid peroxidation inhibitor lazaroid U-83836E on the survival of transplanted striatal neurons. Neither compound increased the survival of grafts, suggesting that NMDA-related excitotoxicity or oxidative stress may not be primary mediators of cell death in striatal grafts.
Mundt-Petersen
U
U
Department of Physiological Sciences, Wallenberg Neuroscience Center, Lund University, Sweden.
Karlsson
J
J
Schierle
G S
GS
Brundin
P
P
D000818:Animals; D016380:Brain Tissue Transplantation; D002470:Cell Survival / Q000187:drug effects; D002839:Chromans / Q000494:pharmacology*; D003342:Corpus Striatum / Q000166:cytology / Q000196:embryology / Q000601:surgery*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D016332:Fetal Tissue Transplantation; D006085:Graft Survival / Q000187:drug effects; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000737:chemistry / Q000637:transplantation*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009498:Neurotoxins / Q000037:antagonists & inhibitors; D018384:Oxidative Stress / Q000187:drug effects; D010750:Phosphoproteins / Q000032:analysis; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002839:Chromans; D051937:Dopamine and cAMP-Regulated Phosphoprotein 32; D018691:Excitatory Amino Acid Antagonists; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D009498:Neurotoxins; D010750:Phosphoproteins; D010879:Piperazines; C066382:U 78517F; D016291:Dizocilpine Maleate