Total synthesis of (+)-amphidinolide P. [corrected].
The convergent enantiocontrolled total synthesis of the 15-membered macrolactone (-)-amphidinolide P is reported. Key transformations include a Sakurai allylation, a Stille coupling for the formation of a fully functionalized acyclic precursor, and intramolecular transesterification.
Williams
D R
DR
Department of Chemistry, Indiana University, Bloomington 47405-7102, USA. williamd@indiana.edu
Myers
B J
BJ
Mi
L
L
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004141:Dinoflagellida / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D018942:Macrolides; D000097442:Amphidinolides
D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D018942:Macrolides; C407987:amphidinolide P; D000097442:Amphidinolides