title: Bilateral antegrade selective cerebral perfusion during surgery on the proximal thoracic aorta.
abstract: OBJECTIVE
  To assess risk factors for hospital death and neurologic outcome after surgery on the proximal thoracic aorta using moderate hypothermic circulatory arrest and bilateral antegrade selective cerebral perfusion.
  
  
  METHODS
  From October 1995 through June 1999, 163 patients with a mean age of 63+/-11 years underwent surgery using bilateral antegrade selective cerebral perfusion. Degenerative aneurysms (55%) and acute type A dissection (28%) were the predominant indications for operation. Forty-six (28%) operations were considered as emergency procedure. Twenty-four (15%) procedures were reoperations.
  
  
  RESULTS
  Mean ASCP time was 48+/-20 min. Hospital mortality was 8.6% (n=14; 70% confidence limit (CL): 6.4-10.8%). Univariate risk factors for hospital mortality were acute type A dissection (P=0.003), central neurologic damage <24 h before the operation (P=0.000), preoperative hemodynamic instability (P=0.034), and rethoracotomy for any cause (P=0.036). Logistic regression analysis identified central neurologic damage <24 h (P=0.006, odds ratio 14) as an independent risk factor. Temporary neurologic damage occurred in 3.8% (n=6; 70% CL: 2.3-5.3%) of patients. Logistic regression analysis indicated preoperative hemodynamic instability (P=0.003, odds ratio 13) as an independent risk factor. Perioperative permanent central neurologic damage was reported in another 3.8% (n=6; 70% CL: 2.3-5.3%) patients. Acute type A dissection (P=0.018, odds ratio 8) and the non-use of a midline sternotomy (P=0.049, odds ratio 8) were retained as independent risk factors.
  
  
  CONCLUSIONS
  Hospital mortality and perioperative neurologic complications are not significantly influenced by the duration of antegrade selective cerebral perfusion. Overall complication rate is low.
authors.affiliation: Department of Cardiopulmonary Surgery, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, Netherlands. dossche@planet.nl
authors.forename: K M
authors.initials: KM
authors.lastname: Dossche
authors.forename: W J
authors.initials: WJ
authors.lastname: Morshuis
authors.forename: M A
authors.initials: MA
authors.lastname: Schepens
authors.forename: F G
authors.initials: FG
authors.lastname: Waanders
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000784:Aortic Dissection / Q000401:mortality / Q000601:surgery; D001013:Aorta, Thoracic / Q000473:pathology / Q000601:surgery*; D017545:Aortic Aneurysm, Thoracic / Q000401:mortality / Q000601:surgery; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control*; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010477:Perfusion / Q000379:methods*; D011336:Probability; D018570:Risk Assessment; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000009:adverse effects* / Q000379:methods