title: [Osteoporosis diet].
abstract: Bone requires a wide variety of nutrients to develop normally and to maintain itself after growth. Most important--in the sense that bony abnormalities are associated with their deficiencies--are protein, calcium, phosphorus, vitamin D, C and K, zinc, manganese and copper. The nutrients most likely to be deficient in citizens of industrialized countries are calcium and vitamin D. In this review of the current literature about nutritional aspects of osteoporosis, we have focused on factors influencing calcium requirement: the principal interacting nutrients are sodium, protein, caffeine, fiber, oxalate, phytate, and the acid/alkaline ash character of the overall diet. Fiber and caffeine decrease calcium absorption from the gut and typically exert relatively minor effects, while sodium, protein and the acid/alkaline balance of the diet increase urinary excretion of calcium and are of much greater significance for the calcium homeostasis. Alkali buffers, whether vegetables or fruits reverse this urinary calcium loss. As long as accompanied by adequate calcium intake, protein-rich diet is not deleterious to bone: a calcium-to-protein ratio of 20:1 (mg calcium/g protein) is recommended. Whether a nutrition-based therapeutic approach to osteoporosis is feasible in the near future is yet unclear: at least there are some recent promising data from in-vitro as well as from rat studies showing that extracts taken from various vegetables, mainly from the onion family inhibit bone resorption in a dose-dependent manner.
authors.affiliation: Universitätsspital/Inselspital Bern.
authors.forename: B
authors.initials: B
authors.lastname: Morselli
authors.forename: B
authors.initials: B
authors.lastname: Neuenschwander
authors.forename: R
authors.initials: R
authors.lastname: Perrelet
authors.forename: K
authors.initials: K
authors.lastname: Lippuner
mesh_terms: D000818:Animals; D002136:Calcium, Dietary / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D009751:Nutritional Requirements; D010024:Osteoporosis / Q000178:diet therapy* / Q000209:etiology; D051381:Rats; D012307:Risk Factors; D014807:Vitamin D / Q000008:administration & dosage
chemical_list: D002136:Calcium, Dietary; D014807:Vitamin D