Medullary CD30+ T cell lymphoma with eosinophilia and hyper-IgE supervening during the relentless course of pityriasis lichenoides.
We report a case of extensive pityriasis lichenoides exhibiting a relentless course. PUVA therapy and oral retinoids cleared temporarily the lesions but did not really halt the course of the disease. Eosinophilia and hyper-IgE occurred after 50 years of evolution. An aggressive medullary CD30+ T cell lymphoma without skin involvement was then diagnosed when pityriasis lichenoides became more extensive and necrotic. The disease was rapidly fatal.
Hermanns-Lê
T
T
Department of Dermatopathology, University of Liège, Belgium.
Piérard
G E
GE
D004802:Eosinophilia / Q000150:complications*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007073:Immunoglobulin E / Q000097:blood*; D017730:Ki-1 Antigen / Q000032:analysis*; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D017514:Pityriasis Lichenoides / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence
D017730:Ki-1 Antigen; D007073:Immunoglobulin E