[The blood enzymatic antioxidative potential in bronchial asthma patients].
This study aims at assessing the ability of asthma patients to defend themselves against the noxious effects of oxidative stress, known being the inflammatory nature of this disorder. As the anti-radical defence ability of the body is reflected by the antioxidative potential of blood and tissues, our study was based on the determination of the activity of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and CAT/SOD and GPx/SOD ratios in the blood. Except for SOD, the activity of which was lower in asthma patients by -34.08%, CAT and GPx had values increased by +32.18%, respectively, with a resulting increase of CAT/SOD and GPx/SOD ratios. Our data, demonstrating a change in per-oxidants/antioxidants balance in favour of the first ones, seem to suggest that in the treatment of bronchial asthma the association of some compounds with antioxidants effects would be beneficial.
Filip
F
F
Disciplina de Medicină Internă Ambulator Adulţi, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Brănişteanu
D
D
Popovici
I
I
Jerca
L
L
Topoliceanu
F
F
Mancaş
G
G
Sărmăşan
V
V
Vartolomei
M
M
Jerca
O
O
Busuioc
D
D
D000328:Adult; D001249:Asthma / Q000201:enzymology*; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D002374:Catalase / Q000097:blood*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008297:Male; D018579:Patient Selection; D012016:Reference Values; D013482:Superoxide Dismutase / Q000097:blood*
D015415:Biomarkers; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase