The interaction of benzimidazole compounds with DNA: intercalation and groove binding modes.
Benzimidazole compounds (Fig. 1) have been synthesized to study their DNA-binding properties. Results obtained with spectroscopy and viscosity measurements indicate that the binding mode varies from intercalation to groove-binding, depending on the number of benzimidazole rings (conformation and size of compounds).
Kubota
Y
Y
Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Iwamoto
T
T
Seki
T
T
D001562:Benzimidazoles / Q000737:chemistry*; D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D014783:Viscosity
D001562:Benzimidazoles; D007364:Intercalating Agents; D004247:DNA