Analysis of HLA antigens in Mycobacterium avium-intracellulare pulmonary infection.
Mycobacterium avium-intracellulare (MAI) pulmonary infection may occur in subjects with no preexisting lung disease and no known immunodeficiency, showing radiologically nodular bronchiectasis. There have remained some unresolved problems in the pathogenesis of the disorder, including the predominance in elderly women and the presence of not deteriorated or deteriorated disease. In the present study, we examined whether immunogenetic susceptibility is present in the disorder. We evaluated 64 cases of MAI disease and analyzed their short-term natural history by assessing symptoms, sputum bacteriology, and chest computed tomographic findings. The frequencies of human leukocyte antigen (HLA) alleles in patients were compared with those in 100 healthy Japanese control subjects. We assayed the HLA-A, -B, -C, -DR, and -DQ antigens serologically. Among 64 patients, 37 (35 females) did not show deterioration, whereas 27 (24 females) showed deterioration after an interval of 30 +/- 15 mo. There was no significant frequency of HLA-B and -C alleles in either group. In 37 not deteriorated patients, DR-6 was positive in 14 (37.8%) patients but in only 16 (16%) control subjects (p = 0.0061, odds ratio [OR] = 3.20). DQ-4 was positive in 10 (27.0%) patients but in only 10 (10%) control subjects (p = 0. 0122, OR = 3.33). In 27 deteriorated patients, HLA-A26 was positive in 14 (51.9%) patients but in only 21 (21.0%) control subjects (p = 0.0015, OR = 4.05). MAI pulmonary infection with nodular bronchiectasis shows two types of outcome, deteriorated and not deteriorated. The subjects with A-26 antigen might indicate the deterioration of MAI infection.
Kubo
K
K
Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan. keishik@hsp.md.shinshu-u.ac.jp
Yamazaki
Y
Y
Hanaoka
M
M
Nomura
H
H
Fujimoto
K
K
Honda
T
T
Ota
M
M
Kamijou
Y
Y
D000368:Aged; D001987:Bronchiectasis / Q000276:immunology* / Q000382:microbiology; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000032:analysis*; D006683:HLA-DQ Antigens / Q000032:analysis; D015808:HLA-DR6 Antigen / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology*
D006680:HLA Antigens; D006683:HLA-DQ Antigens; C060029:HLA-DQ4 antigen; D015808:HLA-DR6 Antigen