[The effect of lead on DNA repair in thymocytes of gamma-irradiated mice].
The effects of Pb on the repair of DNA have been studied in the thymocytes of gamma-irradiated mice exposed to diacetate lead in the drinking water (up to 20 mg/l) for 14-50 days. It is found that lead causes no DNA degradation by itself and renders its genotoxic action indirectly, via inhibiting the repair of single-strand DNA breaks induced by acute gamma-irradiation of mice. Genotoxic effect of lead is reversible that becomes evident when exposed animals are maintained on Pb-free drinking water for 1-2 weeks.
Medvedev
A I
AI
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Chernikov
A V
AV
Kublik
L N
LN
Revina
G I
GI
D000818:Animals; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects*; D005720:Gamma Rays; D007854:Lead / Q000633:toxicity*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D013601:T-Lymphocytes / Q000187:drug effects*
D007854:Lead