Malevamides A-C, new depsipeptides from the marine cyanobacterium Symploca laete-viridis.
Three new depsipeptides, malevamides A-C (1-3), were isolated from the cyanobacterium Symploca laete-viridis collected off the south shore of Oahu, Hawaii. Compounds 1-3 were identified by spectral methods, and partial stereochemical assignments were made by chiral HPLC of the hydrolyzed compounds. At a concentration of 2 microg/mL, compounds 1-3 were inactive against P-388, A-549, and HT-29 cancer cells.
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Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii 96822, USA.
Yoshida
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Scheuer
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PJ
D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C409603:malevamide A; C409604:malevamide B; C409605:malevamide C