title: Intraoral digital imaging documenting recurrent aphthous ulcer healing in 2-octyl cyanoacrylate versus sham-treated lesions.
abstract: OBJECTIVE
  A device to standardize imaging was coupled with a digital intraoral camera to investigate the efficacy of 2-octyl cyanoacrylate (OC) tissue adhesives on the healing of minor aphthous ulcers.
  
  
  METHODS
  Forty-two subjects were enrolled in a patient-blinded, sham-controlled study assessing the effects of 2-OC formulations on ulcer size and healing time. Daily images were made until ulcers were healed. Ulcer image outlines were traced by using a mouse, and ulcer areas were automatically calculated.
  
  
  RESULTS
  A mean difference of -0.15 mm(2) was seen between baseline and next-day measurements (P =.48). The cumulative ulcer area was meaningfully reduced in one OC group compared with the sham group (P =.04). Time to healing was reduced by 1.9 days in the same group compared with the sham group (P =.02).
  
  
  CONCLUSIONS
  The use of digital intraoral images with an integrated measurement reference enhances the accuracy and reproducibility of measurements. 2-OC adhesives hold promise as devices to promote healing of recurrent aphthous ulcers.
authors.affiliation: University of North Carolina School of Dentistry, Chapel Hill 27599-7450, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Ludlow
authors.forename: M J
authors.initials: MJ
authors.lastname: Kutcher
authors.forename: A
authors.initials: A
authors.lastname: Samuelson
mesh_terms: D003487:Cyanoacrylates / Q000627:therapeutic use*; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D023861:Photography, Dental / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D012008:Recurrence; D015203:Reproducibility of Results; D013281:Stomatitis, Aphthous / Q000175:diagnosis* / Q000188:drug therapy*; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014741:Video Recording / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate