title: Locomotor network maturation is transiently delayed in the MAOA-deficient mouse.
abstract: In vivo and in vitro experiments were performed in control (C3H) and monoamine oxidase A (MAOA)-deficient (Tg8) neonatal mice to determine whether MAOA deficiency affected spinal locomotor network maturation. Comparing the swimming behaviors at birth in C3H mice with those in Tg8 mice revealed a delayed role for the hindlimbs in Tg8 swimming, even though adult swimming behavior was acquired at postnatal day 14 (P14) in both strains. Analyzing the locomotor network activity in vitro showed that serotonin (5-HT) induced and modulated locomotor-like discharges in hindlimb ventral roots of C3H but not Tg8 neonates. The Tg8 network began, however, to be affected by 5-HT at P11. Thus both in vivo and in vitro results argue for a transient delay of locomotor network maturation in the Tg8 strain.
authors.affiliation: Centre National de la Recherche Scientifique, Laboratoire de Neurobiologie et Mouvements, 13402 Marseille Cedex 9, France.
authors.forename: J R
authors.initials: JR
authors.lastname: Cazalets
authors.forename: M
authors.initials: M
authors.lastname: Gardette
authors.forename: G
authors.initials: G
authors.lastname: Hilaire
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic; D006614:Hindlimb / Q000502:physiology; D066298:In Vitro Techniques; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008995:Monoamine Oxidase / Q000235:genetics* / Q000378:metabolism; D009046:Motor Neurons / Q000201:enzymology*; D016202:N-Methylaspartate / Q000031:analogs & derivatives / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013116:Spinal Cord / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development*; D013126:Spinal Nerve Roots / Q000187:drug effects / Q000502:physiology; D013550:Swimming / Q000502:physiology*
chemical_list: D018690:Excitatory Amino Acid Agonists; D012701:Serotonin; D016202:N-Methylaspartate; C037699:2-methylaspartic acid; D008995:Monoamine Oxidase