Synthesis and antimicrobial activity of novel arylideneisothiosemicarbazones.
Arylidenimidazoles bearing a thioethereal function in the position 2 of the imidazole ring show good antimicrobial activity. We now report on the synthesis and the biological properties of some novel arylidenisothiosemicarbazones, structurally related to the arylideneiminoimidazoles of which they can be considered the linear precursors. Particular attention has been put on the influence of structural modifications on the biological activity.
Cardia
M C
MC
Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Italy.
Begala
M
M
Delogu
A
A
Maccioni
E
E
Plumitallo
A
A
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D013882:Thiosemicarbazones