Bactericidal/permeability-increasing protein prevents mucosal damage in an experimental rat model of chronic otitis media with effusion.
In this study, the efficacy of bactericidal/permeability-increasing protein (BPI) was assessed in a rat model of chronic otitis media with effusion. BPI injection prevented disturbance of the mucociliary clearance system of the middle ear. Hence, it is postulated that BPI can be a new therapy for chronic otitis media with effusion.
Nell
M J
MJ
Department of Otorhinolaryngology, Leiden University Medical Center, Leiden, The Netherlands. M.J.Nell@lumc.nl
Koerten
H K
HK
Grote
J J
JJ
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins / Q000627:therapeutic use*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000276:immunology / Q000473:pathology; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000276:immunology; D008565:Membrane Proteins; D009092:Mucous Membrane / Q000293:injuries / Q000473:pathology; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051381:Rats; D011994:Recombinant Proteins / Q000627:therapeutic use
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D001798:Blood Proteins; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D011994:Recombinant Proteins; C021623:bactericidal permeability increasing protein