title: A method for fast multislice T1 measurement: feasibility studies on phantoms, young children, and children with Canavan's disease.
abstract: We have developed a multislice protocol for quantitative T1 measurements in which the processing time and the acquisition time are under 2 minutes each for a complete brain study of 15 slices. An echoplanar, inversion-recovery image sequence is designed to collect data suitable for analysis using a linear regression algorithm. The precision is approximately twice the noise to signal ratio of the images. The accuracy of the protocol is better than 1% for T1 in the range 0-2 seconds and deviates slightly for longer T1 values. The protocol is insensitive to B1 field values. If needed, the data can be postprocessed using a slow, nonlinear algorithm to give an accuracy of less than 1% and a precision of approximately the noise to signal ratio throughout a range of T1 values from 0 to 4 seconds.
authors.affiliation: Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
authors.forename: J
authors.initials: J
authors.lastname: Haselgrove
authors.forename: J
authors.initials: J
authors.lastname: Moore
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Traipe
authors.forename: L
authors.initials: L
authors.lastname: Bilaniuk
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000473:pathology*; D017825:Canavan Disease / Q000175:diagnosis*; D002675:Child, Preschool; D003198:Computer Simulation; D005240:Feasibility Studies; D006801:Humans; D007223:Infant; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D017711:Nonlinear Dynamics; D019047:Phantoms, Imaging; D012044:Regression Analysis; D015203:Reproducibility of Results