title: Choriocarcinoma arising in a squamous cell carcinoma of the esophagus.
abstract: Extragonadal germ cell tumors are rare neoplasms with histologic features comparable to those of gonadal origin. Squamous cell carcinoma of the esophagus was diagnosed in a 53-year-old male patient, and was palliated for a short period by cisplatin plus 5-fluorouracil. Clinical deterioration and development of gynecomastia led to diagnosis of hormone-secreting choriocarcinoma that originated within the squamous cell tumor of the esophagus. Salvage chemotherapy affected the markers but not the tumor. Extragonadal choriocarcinoma is a chemosensitive tumor, but when arising within squamous cell carcinoma of the esophagus it may be chemoresistant, and lead to a fatal outcome.
authors.affiliation: Department of Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Merimsky
authors.forename: J
authors.initials: J
authors.lastname: Jossiphov
authors.forename: N
authors.initials: N
authors.lastname: Asna
authors.forename: E
authors.initials: E
authors.lastname: Shmueli
authors.forename: A
authors.initials: A
authors.lastname: Stabsky
authors.forename: M
authors.initials: M
authors.lastname: Inbar
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D002822:Choriocarcinoma / Q000188:drug therapy / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D016879:Salvage Therapy
chemical_list: D014408:Biomarkers, Tumor