Cutaneous CD30 (Ki-1)-positive anaplastic large cell lymphoma preceded by Hodgkin's disease.
A 38-year-old female was diagnosed as Hodgkin's disease of the axillar lymph nodes, nodular sclerosis type, as evidenced by the presence of Reed-Sternberg cells positive for CD30 and CD15 and negative for CD3, CD20, and CD45. She achieved complete remission after combination chemotherapy. Two years later, she noticed a red papule on her public area without any lymph node involvement. The biopsy specimens showed diffuse proliferation of large-sized atypical lymphoid cells positive for CD30 and CD45, and negative for CD3, CD20 and CD15. These findings were mostly compatible with CD30 (Ki-1)-positive anaplastic large cell lymphoma (Ki-1 lymphoma). Our case is considered to be cutaneous Ki-1 lymphoma preceded by Hodgkin's disease.
Terao
H
H
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kiryu
H
H
Ohshima
K
K
Kikuchi
M
M
Furue
M
M
D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001365:Axilla; D001706:Biopsy; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis*; D008198:Lymph Nodes / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D000951:Antigens, Neoplasm; D017730:Ki-1 Antigen