title: Human papillomaviruses and vulvar vestibulitis.
abstract: OBJECTIVE
  To assess the relationship between human papillomavirus (HPV) infection and vulvar vestibulitis syndrome.
  
  
  METHODS
  From November 1995 to December 1997, 135 women with vulvar vestibulitis were compared with 322 controls who had no evidence of vulvar vestibulitis. Human papillomavirus DNA was amplified by polymerase chain reaction and detected with liquid-capture molecular assay.
  
  
  RESULTS
  Human papillomavirus DNA was found in 29.6% of cases and in 23.9% of controls (relative risk [RR] 1.4; 95% confidence interval [CI].8, 2.2). The prevalence of HPV tended to decrease with increasing duration of pain among cases. Thus, prevalences were 37. 5%, 29.6%, and 22.0% for pain durations of 3-6 months, 7-12 months, and 13-24 months, respectively (P =.14). Prevalence of HPV also tended to increase with pain intensity among cases, but that association was not statistically significant (P =.57). Prevalence percentages for women with low, moderate, or severe pain were 27.5%, 28.8%, and 34.4%, respectively. Prevalence of HPV was slightly higher in cases with the most severe pain (34.4%) than in controls (23.9%) (RR 1.8; 95% CI.8, 4.0). In cases with the most pain in the shortest time (3-6 months), prevalence of HPV was double that of controls (50% versus 23.9%) (RR 3.5; 95% CI 1.0, 12.7; P =.054).
  
  
  CONCLUSIONS
  There was little support for the idea that HPV might be related to vulvar vestibulitis.
authors.affiliation: Department of Pathology and Cytology, Quebec City, Canada. carrol.morin@pat.ulaval.ca
authors.forename: C
authors.initials: C
authors.lastname: Morin
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
authors.forename: J
authors.initials: J
authors.lastname: Brisson
authors.forename: M
authors.initials: M
authors.lastname: Fortier
authors.forename: C
authors.initials: C
authors.lastname: Blanchette
authors.forename: A
authors.initials: A
authors.lastname: Meisels
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004279:DNA, Viral / Q000302:isolation & purification; D004414:Dyspareunia / Q000209:etiology; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications*; D016133:Polymerase Chain Reaction; D013577:Syndrome; D014412:Tumor Virus Infections / Q000150:complications*; D014844:Vulva / Q000821:virology; D014847:Vulvitis / Q000821:virology*
chemical_list: D004279:DNA, Viral