title: Yomogin inhibits the degranulation of mast cells and the production of the nitric oxide in activated RAW 264.7 cells.
abstract: Yomogin (1), an eudesmane sesquiterpene isolated from Artemisia princeps, was tested for the effects on the degranulation process of cultured mast cells and on the nitric oxide production in LPS-activated murine macrophages. It demonstrated a significant inhibition on the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner (IC50 value, 50 microM) and also exhibited a potent inhibition on the nitric oxide production from the activated RAW264.7 cells (IC50 value, 3 microM).
authors.forename: S Y
authors.initials: SY
authors.lastname: Ryu
authors.forename: M H
authors.initials: MH
authors.lastname: Oak
authors.forename: K M
authors.initials: KM
authors.lastname: Kim
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane
chemical_list: D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C117320:yomogin; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase