[Comparative characteristics of immunoglobulin-synthesizing cell and immunoregulatory T-lymphocyte subpopulation contents in human lymphatic nodes and the spleen].
The content of lymphocytes producing different classes of immunoglobulins (IgA, IgM and IgG) and immunoregulatory T cell subpopulations (CD3, CD4, CD8) was assessed in structural components of T- and B- zones of lymph nodes of visceral and somatic groups and spleen in man. Forensic autopsy material obtained from 48 men of 2 age groups: 31-60 and 61-75 years was studied. The absence of direct correlation between the quantity of plasma cells in B-zone of peripheral lymphoid organs and their functional activity was shown. The results obtained may serve as an initial point in studying immunomorphological reorganizations of human peripheral lymphoid organs in development of immunopathological processes.
Pigarevskiĭ
P V
PV
N.N. Anichkov Laboratory of Atherosclerosis, Russian Academy of Medical Sciences, St. Petersburg.
D000293:Adolescent; D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000378:metabolism; D015704:CD4 Antigens / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000166:cytology* / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology / Q000378:metabolism
D017252:CD3 Complex; D015704:CD4 Antigens; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins