CCL chemokines and asthma.
Airway eosinophilia is a characteristic of bronchial asthma. Eosinophils are considered to cause tissue damage through the release of toxic proteases, lipid mediators, cytokines and oxygen free radicals. The discovery of chemokines and the demonstration that some members of this cytokine superfamily are implicated in the recruitment of eosinophils offers an opportunity for a novel therapeutic approach in asthma.
Teran
L M
LM
Instituto Nacional de Enfermedades Respiratorias, Calz de Tlalpan 4502, Mexico DF, Mexico. lmteran@diego.iner.gob.mx
D001249:Asthma / Q000276:immunology* / Q000821:virology; D002465:Cell Movement / Q000187:drug effects; D054413:Chemokine CCL11; D018946:Chemokine CCL5 / Q000276:immunology* / Q000494:pharmacology; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil / Q000276:immunology; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D008024:Ligands; D018945:Monocyte Chemoattractant Proteins / Q000276:immunology / Q000494:pharmacology; D019707:Receptors, Chemokine / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology / Q000276:immunology
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D018946:Chemokine CCL5; D019742:Chemokines, CC; D002631:Chemotactic Factors, Eosinophil; D016207:Cytokines; D008024:Ligands; D018945:Monocyte Chemoattractant Proteins; D019707:Receptors, Chemokine