title: [Myocardial perfusion at rest and during stress. MR signal characteristics of persistent and reversible myocardial ischemia].
abstract: OBJECTIVE
  Performance of combined rest/stress MR perfusion studies and the analysis of qualitative signal intensity parameters in comparison with 99mTc-SestaMIBI SPECT in patients with known coronary artery disease (CAD).
  
  
  METHODS
  Sixteen patients with CAD underwent MR myocardial perfusion assessment at rest and after dipyridamole-induced hyperemia. Qualitative parameters (SI increase, SI upslope) of the SI time-curves were evaluated and characteristics of normal, reversible and persistent hypoperfused myocardium as assessed by 99mTc-SestaMIBI SPECT were compared.
  
  
  RESULTS
  Compared with the rest values, normal myocardium showed a significant increase of the SI upslope during hyperemia (P < 0.001), whereas persistent (P = 0.07) and reversible (P = 0.15) hypo-perfusions showed only minor changes. SI increase over baseline also showed a significant increase only in normal myocardium (P < 0.001). At rest, reversible ischemic areas showed no significant differences from normal myocardium, whereas during hyperemia SI increase was significantly lower (P = 0.02).
  
  
  CONCLUSIONS
  Qualitative SI parameters of a combined rest/stress MR myocardial perfusion study allow to differentiate normal from reversibly or persistently hypoperfused myocardium.
authors.affiliation: Institut für Klinische Radiologie, Ludwig-Maximilians-Universität München. wintersperger@ikra.med.uni-muenchen.de
authors.forename: B J
authors.initials: BJ
authors.lastname: Wintersperger
authors.forename: H V
authors.initials: HV
authors.lastname: Penzkofer
authors.forename: A
authors.initials: A
authors.lastname: Knez
authors.forename: A
authors.initials: A
authors.lastname: Huber
authors.forename: M
authors.initials: M
authors.lastname: Kerner
authors.forename: M
authors.initials: M
authors.lastname: Meininger
authors.forename: P
authors.initials: P
authors.lastname: Knesewitsch
authors.forename: J
authors.initials: J
authors.lastname: Scheidler
authors.forename: R
authors.initials: R
authors.lastname: Haberl
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000328:Adult; D000368:Aged; D003287:Contrast Media; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D004176:Dipyridamole; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents
chemical_list: D003287:Contrast Media; D014665:Vasodilator Agents; D004176:Dipyridamole; D017256:Technetium Tc 99m Sestamibi; D019786:Gadolinium DTPA