[Isoprostanes: new markers of oxidative stress. Fundamental and clinical aspects].
A novel family of prostaglandin F2 isomers, called F2-isoprostanes, produced in large quantities in vivo by a free radical peroxidation of arachidonic acid, has recently been described. The quantification of the two major isoforms (isoprostaglandin F2alpha type-III and VI) in biological fluids and tissues as markers of lipid peroxidation appears to be an important advance in our ability to explore the role of free radicals in the pathogenesis of human disease. In addition, F2-isoporstanes quantification seems promising as intermediate endpoints for clinical studies of antioxidant therapies.
Cracowski
J L
JL
Stanke-Labesque
F
F
Bessard
G
G
D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D016718:Arachidonic Acid / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000737:chemistry; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000145:classification / Q000502:physiology; D028441:F2-Isoprostanes; D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*
D000975:Antioxidants; D015415:Biomarkers; D028441:F2-Isoprostanes; D005609:Free Radicals; C075750:8-epi-prostaglandin F2alpha; D016718:Arachidonic Acid; D015237:Dinoprost