title: Minimal liver resection strongly stimulates the growth of human colon cancer in the liver of nude mice.
abstract: Partial hepatectomy has been widely employed in clinical practice as the therapy of choice for primary and metastatic liver tumors. However, the recurrence rate after the treatment remains high, which is most likely due to the growth of residual microscopic lesions. Previous studies in murine models demonstrated that a 70% hepatectomy significantly accelerated the growth of ectopically implanted tumors. In this study, we reported the effect of partial hepatectomy on the growth of two human colon cancers (Co-3 and AC3603) implanted in the liver of nude mice using the technique of surgical implantation of histologically intact tumor tissue. Our results showed a dramatic acceleration of tumor growth following 30% partial hepatectomy, which resembles clinical procedures. Tumor volumes were assessed with calipers on day-15 by abdominal palpation and on day-30 at autopsy by direct measurement. For both Co-3 and AC3603, tumor volumes in the hepatectomized animals were significantly larger than the control at the above two time points (P < 0.001). The results demonstrate the stimulating effect of partial hepatectomy directly on the tumor growth in the liver, in contrast to previous studies on ectopic tumors. Furthermore, since conservative partial hepatectomy (30%) is normally used in clinical practice for surgical treatment of liver metastasis, the animal models presented here should be useful for the clinical investigation of the high recurrence rate of liver metastasis following partial hepatectomy.
authors.affiliation: AntiCancer, Inc., San Diego, California 92111, USA.
authors.forename: B
authors.initials: B
authors.lastname: Rashidi
authors.forename: Z
authors.initials: Z
authors.lastname: An
authors.forename: F X
authors.initials: FX
authors.lastname: Sun
authors.forename: A
authors.initials: A
authors.lastname: Sasson
authors.forename: R
authors.initials: R
authors.lastname: Gamagammi
authors.forename: A R
authors.initials: AR
authors.lastname: Moossa
authors.forename: R M
authors.initials: RM
authors.lastname: Hoffman
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000556:secondary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation