Age-dependent changes in B lymphocyte development in man and mouse.
In recent years, detailed analyses of B cell development in both humans and mice have revealed similar subsets of precursors along the same pathway of differentiation. From these studies it also became clear that both species undergo age related changes in this B lymphocyte development program. In this review we summarize these findings and discuss, potential mechanisms underlying these age related changes, and possible causative correlations between these changes and age related B cell abnormalities.
Ghia
P
P
Laboratorio di Immunologia Oncologica, Istituto per la Ricerca e la Cura del Cancro, Candiolo, Italy.
Melchers
F
F
Rolink
A G
AG
D000375:Aging / Q000502:physiology*; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D019891:Leukopoiesis; D051379:Mice / Q000502:physiology