Endothelial lipase: a new member of the triglyceride lipase gene family.
The triglyceride lipase gene family plays a central role in intestinal lipid absorption, energy homeostasis, lipoprotein metabolism, and atherosclerosis. A new member of this gene family, termed endothelial lipase, was recently reported. The presence of key functional motifs, the endothelial synthesis, the enzymatic profile, and the in-vivo metabolic effects of endothelial lipase suggest that, like other members of this gene family, endothelial lipase may play a role in energy delivery to tissues and in modulating lipoprotein metabolism, and could impact on atherogenesis.
Rader
D J
DJ
University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA. rader@mail.med.upenn.edu
Jaye
M
M
D001161:Arteriosclerosis / Q000201:enzymology; D004730:Endothelium, Vascular / Q000201:enzymology; D019143:Evolution, Molecular; D006801:Humans; D008049:Lipase / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism; D008954:Models, Biological; D014018:Tissue Distribution
D008074:Lipoproteins; C410382:LIPG protein, human; D008049:Lipase