Growth-factor enhancement of compromised gut function following massive small-bowel resection.
Our laboratory has shown that epidermal growth factor (EGF) and hepatocyte growth factor (HGF) can improve the function of normal rat small intestine. This study was designed to evaluate the role of these growth factors on the residual small intestine following massive (80%) small bowel resection. Our data demonstrate that EGF and HGF can enhance intestinal substrate absorption and mucosal mass beyond that which occurs with intestinal adaptation. These growth factors may be beneficial in the management of children with short bowel syndrome.
Schwartz
M Z
MZ
Department of Surgery, Dupont Hospital for Children, Wilmington, DE 19899, USA.
Kato
Y
Y
Yu
D
D
Lukish
J R
JR
D000818:Animals; D002648:Child; D004247:DNA / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000627:therapeutic use*; D017228:Hepatocyte Growth Factor / Q000627:therapeutic use*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D007413:Intestinal Mucosa / Q000502:physiology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012778:Short Bowel Syndrome / Q000188:drug therapy*
D004815:Epidermal Growth Factor; D017228:Hepatocyte Growth Factor; D004247:DNA