title: Novel 3-(4-piperidinylthio)-1H-indoles as potent nonopioid orally active central analgesics.
abstract: A series of 3-(4-piperidinylthio)-1H-indoles was synthesized and evaluated in mice in the phenylbenzoquinone(PBQ)-induced writhing and hot plate tests. Most of these compounds are good analgesics with activities comparable to that of morphine. Among them compound 1i (UP 237-61), which has a strong serotonin binding profile, has an interesting antinociceptive activity which is not reversed by naloxone.
authors.affiliation: Laboratoires UPSA, Rueil Malmaison, France. d.potin@cerep.fr
authors.forename: D
authors.initials: D
authors.lastname: Potin
authors.forename: V
authors.initials: V
authors.lastname: Parnet
authors.forename: J M
authors.initials: JM
authors.lastname: Teulon
authors.forename: F
authors.initials: F
authors.lastname: Camborde
authors.forename: F
authors.initials: F
authors.lastname: Caussade
authors.forename: J
authors.initials: J
authors.lastname: Meignen
authors.forename: D
authors.initials: D
authors.lastname: Provost
authors.forename: A
authors.initials: A
authors.lastname: Cloarec
mesh_terms: D000284:Administration, Oral; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice
chemical_list: D018712:Analgesics, Non-Narcotic; D007211:Indoles