title: Osseous disease in patients with pulmonary sarcoidosis and musculoskeletal symptoms.
abstract: Little is known about the clinical manifestations and correlates of osseous sarcoidosis and few data exist to guide pulmonologists in their evaluation of patients for possible osseous involvement. To determine the relationship between pulmonary and osseous sarcoidosis, and to develop an algorithm for use by pulmonologists in assessing patients with suspected osseous sarcoidosis, we conducted a retrospective, case control study of patients with pulmonary sarcoidosis and musculoskeletal complaints who were evaluated for osseous disease. All patients underwent a standard evaluation to include physical examination, chest radiograph (CXR), spirometry (PFTs), bone scintigraphy and plain radiographs of the hands and feet. Patients completed a health assessment questionnaire and serum angiotenisin converting enzyme, erythrocyte sedimentation rate, and C-reactive protein were measured. Patients eventually diagnosed with osseous sarcoidosis were compared to those lacking osseous involvement. Osseous involvement in patients with pulmonary sarcoidosis and musculoskeletal symptoms was common and seen in 38.9% of subjects. Patients with osseous sarcoidosis were more likely to concomitantly suffer from cutaneous sarcoidosis and to have elevated ACE levels and ESRs. No measure of pulmonary involvement (CXR stage, PFTs or symptoms) differentiated patients with osseous sarcoidosis from those without this condition. In cases of osseous sarcoidosis, bone scintigraphy identified a mean of four sites of osseous involvement, some of which would have been missed with the use of plain radiographs limited to the hands and feet. We conclude that in patients with pulmonary sarcoidosis who have significant musculoskeletal complaints, osseous involvement is frequent. Pulmonary features of sarcoidosis do not differ between patients with and without osseous disease. Bone scintigraphy aids in the evaluation of these patients.
authors.affiliation: Pulmonary & Critical Care Medicine Service, Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: Shorr
authors.forename: F T
authors.initials: FT
authors.lastname: Murphy
authors.forename: W R
authors.initials: WR
authors.lastname: Gilliland
authors.forename: W
authors.initials: W
authors.lastname: Hnatiuk
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001847:Bone Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000175:diagnosis* / Q000503:physiopathology; D017565:Sarcoidosis, Pulmonary / Q000150:complications / Q000503:physiopathology; D014797:Vital Capacity
chemical_list: D015415:Biomarkers; D007703:Peptidyl-Dipeptidase A