Stem cell therapy and gene transfer for regeneration.
The committed stem and progenitor cells have been recently isolated from various adult tissues, including hematopoietic stem cell, neural stem cell, mesenchymal stem cell and endothelial progenitor cell. These adult stem cells have several advantages as compared with embryonic stem cells as their practical therapeutic application for tissue regeneration. In this review, we discuss the promising gene therapy application of adult stem and progenitor cells in terms of modifying stem cell potency, altering organ property, accelerating regeneration and forming expressional organization.
Asahara
T
T
St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA.
Kalka
C
C
Isner
J M
JM
D000328:Adult; D000818:Animals; D000229:Dependovirus / Q000235:genetics; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D016086:Lentivirus / Q000235:genetics; D012038:Regeneration; D012190:Retroviridae / Q000235:genetics; D033581:Stem Cell Transplantation; D014947:Wounds and Injuries / Q000628:therapy*