Transcriptional control of T cell development.
Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.
Osborne
B A
BA
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA. osborne@vasci.umass.edu.
D016923:Cell Death; D002454:Cell Differentiation; D005786:Gene Expression Regulation; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology* / Q000254:growth & development; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D014157:Transcription Factors