Tau polymorphisms are not associated with Alzheimer's disease.
Alzheimer's disease (AD) is one of a number of neurodegenerative conditions including frontotemporal dementia and progressive supranuclear palsy that are associated with abnormal tau protein aggregates in neurons. Mutations in the tau gene cause familial forms of frontotemporal dementia and alleles of the tau gene have been associated with risk for progressive supranuclear palsy. However, studies evaluating whether polymorphic variation in tau is associated with AD have produced conflicting results. We investigated the role of the tau exon 2 polymorphism in a large sample of AD cases and controls and found no evidence that polymorphic variation in tau is associated AD.
Kwon
J M
JM
Department of Neurology, Washington University School of Medicine, 4559 Scott Avenue, 660 South Euclid, St. Louis, USA.
Nowotny
P
P
Shah
P K
PK
Chakraverty
S
S
Norton
J
J
Morris
J C
JC
Goate
A M
AM
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins