title: The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics.
abstract: Anew sequence, which encoded a novel G protein-coupled receptor, was disclosed by two different groups, using the nucleic acid probes based on the delta opioid receptor, first cloned in 1992. The new receptor, which Meunier called opioid-receptor-like 1 (ORL-1), was shown to share high homology with the opioid receptors and therefore thought to be a potential target for new analgesics. In this respect, the present review reports on the literature referring to ORL-1, to its natural ligand (nociceptin or orphanin FQ) and to several synthetic analogues recently described, both as agonists or antagonists at the receptor.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Viale Abruzzi 42, 20131, Milan, Italy. Daniela.Barlocco@unimi.it
authors.forename: D
authors.initials: D
authors.lastname: Barlocco
authors.forename: G
authors.initials: G
authors.lastname: Cignarella
authors.forename: G A
authors.initials: GA
authors.lastname: Giardina
authors.forename: L
authors.initials: L
authors.lastname: Toma
mesh_terms: D000595:Amino Acid Sequence; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011957:Receptors, Opioid / Q000187:drug effects*; D000094942:Nociceptin Receptor
chemical_list: D000701:Analgesics, Opioid; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; C000722283:OPRL1 protein, human