title: The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor.
abstract: Experimental autoimmune encephalomyelitis develops in mice immunized with CNS antigens. To elucidate the role that specific proinflammatory cytokines play in the induction of this process we examined the development of EAE in mice with targeted disruptions of the TNF p55 or p75 or the IL-1 p80 receptors. EAE developed in mice with either one or both TNF receptors deleted although the onset of disease in mice with the p55 receptor deleted was delayed. However, mice with a deletion of the IL-1 p80 receptor failed to develop any inflammatory lesions in the CNS or evidence of clinical EAE. Thus we conclude that TNF or its receptors contribute to, but are not necessary for, the induction of EAE while the IL-1 p80 receptor is absolutely required. The p55 TNF receptor plays a role in determining the onset of disease and its severity.
authors.affiliation: Department of Medicine and Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA.
authors.forename: J
authors.initials: J
authors.lastname: Schiffenbauer
authors.forename: W J
authors.initials: WJ
authors.lastname: Streit
authors.forename: E
authors.initials: E
authors.lastname: Butfiloski
authors.forename: M
authors.initials: M
authors.lastname: LaBow
authors.forename: C
authors.initials: C
authors.lastname: Edwards
authors.forename: L L
authors.initials: LL
authors.lastname: Moldawer
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D017472:Receptors, Interleukin-1 / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D012720:Severity of Illness Index; D015398:Signal Transduction
chemical_list: D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor