title: The diagnostic value of stapedius reflex and stapedius reflex exhaustion in myasthenia gravis.
abstract: Authors studies impedance, stapedius reflex thresholds and stapedius muscle exhaustion on 31 ears of 16 MG patients. Investigations were carried out using GSI 33 computer-assisted middle ear analyzator. Stapedius reflex threshold values were increased in 93% of patients. Stapedius exhaustion was observed in 71% of patients. After the administration of the reversible cholinesterase inhibitor Mestinon (60 mg pyridostigmin bromide), reflex threshold decreased and exhaustion occurred in only 50% of cases. Authors review the literature in context with the audiometric diagnostics of MG and also recommend the use of these methods in more complicated ocular and bulbar cases of MG.
authors.affiliation: Clinics of Otolaryngology, University Medical School of Debrecen, Hungary. TOTHL@jaguar.dotc.hu
authors.forename: L
authors.initials: L
authors.lastname: Tóth
authors.forename: I
authors.initials: I
authors.lastname: Lampé
authors.forename: P
authors.initials: P
authors.lastname: Diószeghy
authors.forename: G
authors.initials: G
authors.lastname: Répássy
mesh_terms: D000158:Acoustic Impedance Tests; D000328:Adult; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000503:physiopathology*; D011729:Pyridostigmine Bromide / Q000627:therapeutic use; D012022:Reflex, Acoustic / Q000187:drug effects / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D013198:Stapedius / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D002800:Cholinesterase Inhibitors; D011729:Pyridostigmine Bromide