Human papillomavirus type 16 E7 oncoprotein represses transcription of human fibronectin.
The E7 oncoprotein encoded by human papillomavirus (HPV) type 16 repressed the transcription of fibronectin, a key component of the extracellular matrix. This repression, detected in several HPV-positive nontumorigenic and tumorigenic cell lines, was abolished when the Cys-X-X-Cys repeats in E7 were disrupted.
Rey
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School of Dentistry, University of California at Los Angeles, Los Angeles, California 90095-1668, USA.
Lee
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S
Park
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NH
D002460:Cell Line; D015536:Down-Regulation; D005260:Female; D005353:Fibronectins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism*; D027383:Papillomaviridae / Q000235:genetics / Q000378:metabolism*; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000821:virology; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D014412:Tumor Virus Infections / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000821:virology
D005353:Fibronectins; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16; D008156:Luciferases