title: Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones.
abstract: Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and 1H NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested.
authors.affiliation: Department of Chemistry, Faculty of Science, Hacettepe University, Ankara, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Güner
authors.forename: S
authors.initials: S
authors.lastname: Yildirir
authors.forename: B
authors.initials: B
authors.lastname: Ozçelik
authors.forename: U
authors.initials: U
authors.lastname: Abbasoğlu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001384:Azetidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007769:Lactams; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001384:Azetidines; D007769:Lactams