title: Using GeneWise in the Drosophila annotation experiment.
abstract: The GeneWise method for combining gene prediction and homology searches was applied to the 2.9-Mb region from Drosophila melanogaster. The results from the Genome Annotation Assessment Project (GASP) showed that GeneWise provided reasonably accurate gene predictions. Further investigation indicates that many of the incorrect gene predictions from GeneWise were due to transposons with valid protein-coding genes and the remaining cases are pseudogenes or possible annotation oversights.
authors.affiliation: Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Birney@ebi.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Birney
authors.forename: R
authors.initials: R
authors.lastname: Durbin
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods / Q000706:statistics & numerical data; D016208:Databases, Factual; D004331:Drosophila melanogaster / Q000235:genetics*; D017344:Genes, Insect / Q000235:genetics*; D016678:Genome; D012689:Sequence Homology, Nucleic Acid; D012984:Software