Do seizures cause neuronal damage in rat amygdala kindling?
Using unbiased stereology, we estimated total neuronal numbers in the lateral, basal and accessory basal nuclei of the amygdala and in the hilus of the dentate gyrus 6 months after the induction of amygdala kindling. In kindled rats, there was no decrease in the total number of neurons in the various amygdaloid regions or the hilus compared to sham-operated animals. Furthermore, there was no correlation between the total duration of afterdischarges or the number of electrical stimulations and the number of neurons. Our data indicate that when using unbiased stereological methods, total neuronal number in the amygdala or hilus are not reduced after few amygdala-induced seizures.
Tuunanen
J
J
A.I. Virtanen Institute, University of Kuopio, Finland.
Pitkänen
A
A
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002452:Cell Count; D018891:Dentate Gyrus / Q000473:pathology; D004594:Electrophysiology; D007696:Kindling, Neurologic; D008297:Male; D009474:Neurons / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology