title: A mechanical arthrometer to measure knee joint contracture in rats.
abstract: Animal models for joint diseases are necessary for in vivo studies. Joint contractures are characterized by lack of the normal range of motion of a joint most often due to increased soft tissue stiffness. Biological and biochemical data have been obtained but biomechanical data on small animals are rare. An instrument was developed to measure rat knee angular displacement at various soft tissue loads in normal and pathological circumstances. This article describes the instrument and reports its reproducibility and accuracy. The reproducibility and accuracy of this instrument was found to be acceptable thereby validating its use for research purposes with adult rat knees.
authors.affiliation: Department of Medicine, University of Ottawa, Ont., Canada.
authors.forename: G
authors.initials: G
authors.lastname: Trudel
authors.forename: P A
authors.initials: PA
authors.lastname: O'Neill
authors.forename: L A
authors.initials: LA
authors.lastname: Goudreau
mesh_terms: D000818:Animals; D000886:Anthropometry / Q000295:instrumentation*; D015982:Bias; D003286:Contracture / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D004867:Equipment Design; D007719:Knee Joint; D016059:Range of Motion, Articular / Q000502:physiology*; D051381:Rats; D015203:Reproducibility of Results; D019415:Torque; D016474:Weight-Bearing