title: The effects of propofol on heart rate, arterial pressure and adelta and C somatosympathetic reflexes in anaesthetized dogs.
abstract: The effects of propofol on mean arterial pressure, heart rate and Adelta and C somatosympathetic reflexes, recorded in renal nerves, evoked by repeated individual supramaximal electrical stimuli applied to radial nerves, were observed in anaesthetized, paralysed and artificially ventilated dogs. Propofol was infused at rates from 0.4 to 2.0 mg kg-1 min-1. Mean C and Adelta reflexes were abolished at plasma concentrations (mean, SEM) of 24.3 (3.3) and 29.2 (2.6) microg mL-1 (P < 0.05), respectively, when mean arterial pressure and mean heart rate were reduced by approximately 55% (P < 0.01) and 26% (P > 0.05), respectively. Recovery of Adelta and C reflexes occurred at plasma concentrations of 13.1 (2.3) and 9.9 (1.3) microg mL-1 (P > 0.05), respectively. There was a log- arithmically linearly related fall in mean arterial pressure by 70% up to a plasma concentration approximately 97 microg mL-1 (r 2=0.7) with a 28% reduction in heart rate which was uncorrelated with the plasma concentrations (r 2=0.12). In conclusion, propofol abolished Adelta and C responses at comparable plasma concentrations and caused a major reduction in both mean arterial pressure and heart rate which is consistent with resetting of the baroreflexes. The reduction in mean arterial pressure was logarithmically, linearly correlated with a progressive increase in plasma concentrations without evidence of a ceiling effect.
authors.affiliation: Department of Anaesthetics and Intensive Care, Imperial College School of Medicine, Hammersmith Hospital, London UK.
authors.forename: J G
authors.initials: JG
authors.lastname: Whitwam
authors.forename: D C
authors.initials: DC
authors.lastname: Galletly
authors.forename: D
authors.initials: D
authors.lastname: Ma
authors.forename: M K
authors.initials: MK
authors.lastname: Chakrabarti
mesh_terms: D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D000818:Animals; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D007262:Infusions, Intravenous; D007668:Kidney / Q000294:innervation; D016014:Linear Models; D009412:Nerve Fibers / Q000187:drug effects*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects*; D019148:Neuromuscular Blockade; D010865:Pilot Projects; D015742:Propofol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D011826:Radial Nerve / Q000187:drug effects / Q000502:physiology; D012018:Reflex / Q000187:drug effects*; D012121:Respiration, Artificial; D013564:Sympathetic Nervous System / Q000187:drug effects*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol