Effect of Ocimum sanctum fixed oil on vascular permeability and leucocytes migration.
Ocimum sanctum fixed oil significantly inhibited the rise in protein concentration and dye leakage in peritoneal fluid in experimentally induced peritoneal inflammation in mice. In carrageenan-induced pleurisy in rats, the fixed oil showed significant inhibition of leucocytes migration in the pleural exudate. The results suggest that the fixed oil can inhibit enhancement of the vascular/capillary permability and leucocyte migration following inflammatory stimulus.
Singh
S
S
College of Pharmacy (University of Delhi), New Delhi, India.
Majumdar
D K
DK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D051379:Mice; D018649:Ocimum basilicum; D010538:Peritonitis / Q000188:drug therapy; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats
D000893:Anti-Inflammatory Agents; D010938:Plant Oils; C080118:ocimum oil