Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity.
We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro.
Stead
P
P
Bioprocessing Unit, Glaxo-Wellcome Medicines Research Centre, Stevenage, Herts, UK. ps29705@glaxowellcome.co.uk
Hiscox
S
S
Robinson
P S
PS
Pike
N B
NB
Sidebottom
P J
PJ
Roberts
A D
AD
Taylor
N L
NL
Wright
A E
AE
Pomponi
S A
SA
Langley
D
D
D000818:Animals; D006367:HeLa Cells; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D018179:Receptors, Thrombin / Q000037:antagonists & inhibitors*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
D018179:Receptors, Thrombin; D012503:Saponins; C412031:eryloside F; C093430:penasterol; D007810:Lanosterol