title: Mycoplasma genitalium in males with nongonococcal urethritis: prevalence and clinical efficacy of eradication.
abstract: BACKGROUND
  Mycoplasma genitalium is regarded as a potential pathogen of the human urogenital tract based on prevalence findings of several European studies.
  
  
  OBJECTIVE
  To determine the prevalence of M genitalium in urethral specimens of symptomatic patients with nongonococcal urethritis and from asymptomatic patients attending a sexually transmitted disease clinic in Milan, and to verify the clinical efficacy of M genitalium eradication by antibiotic treatment.
  
  
  METHODS
  From May 1998 to late April 1999, a routine analysis for M genitalium by DNA amplification (polymerase chain reaction) was performed in patients attending the Institute of Dermatological Science in Milan. The authors examined urethral swabs from 178 symptomatic and 23 asymptomatic males. M genitalium-positive patients were clinically and microbiologically tested after treatment with either doxycycline or azithromycin.
  
  
  RESULTS
  Among males with nongonococcal urethritis, M genitalium was detected in 14.0% of patients as the only agent; in 15.1% of patients in association with Chlamydia trachomatis and/or Ureaplasma urealyticum; and in 1 asymptomatic patient. In all symptomatic M genitalium-positive patients, antibiotic treatment eradicated the infection and cured clinical symptoms.
  
  
  CONCLUSIONS
  These data reveal the high prevalence of M genitalium in symptomatic patients, the rarity of asymptomatic carriers, the high susceptibility to antibiotic treatment, and the clinical efficacy of M genitalium eradication. Moreover, data confirm the etiologic role of M genitalium in inflammatory processes of the human urogenital tract in the Mediterranean area.
authors.affiliation: Institute of Dermatological Science of the University of Milan, IRCCS Ospedale Maggiore, Italy. loretiera@yahoo.it
authors.forename: D
authors.initials: D
authors.lastname: Gambini
authors.forename: I
authors.initials: I
authors.lastname: Decleva
authors.forename: L
authors.initials: L
authors.lastname: Lupica
authors.forename: M
authors.initials: M
authors.lastname: Ghislanzoni
authors.forename: M
authors.initials: M
authors.lastname: Cusini
authors.forename: E
authors.initials: E
authors.lastname: Alessi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000302:isolation & purification; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009174:Mycoplasma / Q000235:genetics / Q000302:isolation & purification*; D009175:Mycoplasma Infections / Q000453:epidemiology* / Q000517:prevention & control*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014526:Urethritis / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control
chemical_list: D004269:DNA, Bacterial