The use of an anabolic steroid (nandrolone decanoate) to improve nutritional status after esophageal resection for carcinoma.
Anabolic steroids increase appetite and muscle mass. This randomized, double-blind trial investigates any nutritional benefits of anabolic steroid in patients after surgery for esophageal cancer. Forty patients were recruited: 19 patients had five injections of 50 mg nandrolone decanoate and 21 patients received placebo over 3 months, starting 1 month after surgery. Measurements of body weight, mid-arm muscle circumference (MAMC) and appetite were taken over a 6-month period. Nutrition was optimized by dietary advice and by esophageal dilatation if required. Percent ideal weight, percent ideal MAMC and appetite score did not show significant differences between steroid and placebo groups, but there was a trend to an increase over 6 months for percent ideal MAMC in the test group. With this protocol, we have experienced minimal side-effects. However, we have not demonstrated any therapeutic benefit with low-dose steroid. An increased dose schedule over a longer period might produce a significant response.
Darnton
S J
SJ
Department of Thoracic Surgery, Birmingham Heartlands Hospital, UK. ocfdarnton@mcmail.com
Zgainski
B
B
Grenier
I
I
Allister
K
K
Hiller
L
L
McManus
K G
KG
Steyn
R S
RS
D000368:Aged; D000369:Aged, 80 and over; D045930:Anabolic Agents / Q000008:administration & dosage*; D000886:Anthropometry; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000601:surgery*; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004938:Esophageal Neoplasms / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009277:Nandrolone / Q000008:administration & dosage*; D009748:Nutrition Disorders / Q000188:drug therapy* / Q000209:etiology; D009752:Nutritional Status / Q000187:drug effects*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
D045930:Anabolic Agents; D009277:Nandrolone