Angiogenesis in ovarian clear cell carcinoma and its relation to endometriosis.
Twenty-five patients with ovarian clear cell carcinoma (CC-Ca) were enrolled in this study, and tumor cell expression of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) was investigated, and correlated with the microvessel count (MVC) and the impact of complication endometriosis. Expression of VEGF was strongly positive in 16 cases, weakly positive in 6 cases, and negative in 3 cases. Expression of PD-ECGF was strongly positive in 11 cases, weakly positive in 6 cases, and negative in 8 cases. VEGF expression and the MVC were significantly correlated (p<0.01), and there were no correlations among complication by endometriosis, expression of VEGF, expression of PD-ECGF, and MVC.
Deguchi
M
M
Department of Obstetrics and Gynecology, Wakayama Medical College, Kihoku Hospital, Katsuragi, Wakayama 649-7113, Japan.
Matsumoto
Y
Y
Ishiko
O
O
Ogita
S
S
D018262:Adenocarcinoma, Clear Cell / Q000098:blood supply* / Q000150:complications / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D004715:Endometriosis / Q000150:complications*; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000032:analysis; D008833:Microcirculation / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D010051:Ovarian Neoplasms / Q000098:blood supply* / Q000150:complications / Q000473:pathology / Q000601:surgery; D010982:Platelet-Derived Growth Factor / Q000032:analysis; D013939:Thymidine Phosphorylase / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013939:Thymidine Phosphorylase