The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer.
Pretreatment with the butanol extract of the water fraction of Phyllanthus emblica fruits at the dose of 100 mg/kg body-weight, orally administered to rats for 10 consecutive days, was found to enhance secretion of gastric mucus and hexosamine (P<0.001) in the indomethacin induced ulceration of rats. The morphological observations also supported a protective effect of the stomach wall from lesion. The indomethacin treatment of the premedicated animals with the drug hardly affected either the malondialdehyde (MDA) or superoxide dismutase (SOD) level in gastric tissue while the ulcerative agent itself significantly enhanced both the levels. An antioxidant property appears to be predominantly responsible for this cytoprotective action of the drug.
Bandyopadhyay
S K
SK
University College of Medicine, Calcutta, India.
Pakrashi
S C
SC
Pakrashi
A
A
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D019610:Cytoprotection; D019665:Euphorbiaceae; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005638:Fruit; D006595:Hexosamines / Q000032:analysis; D007213:Indomethacin / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009093:Mucus / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D006595:Hexosamines; D013482:Superoxide Dismutase; D007213:Indomethacin