title: Characterization of ferrochelatase (hemH) mutations in Haemophilus influenzae.
abstract: Haemophilus influenzae lacks most of the biosynthetic enzymes for hemin synthesis. However, the organism has retained ferrochelatase activity, which we identified to be encoded by a hemH-homologous gene. In this report we characterize the growth physiology conferred by hemH mutations under infection and laboratory conditions.
authors.affiliation: Zentrum für Infektionsforschung, Universität Würzburg, 97070 Würzburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Schlör
authors.forename: M
authors.initials: M
authors.lastname: Herbert
authors.forename: M
authors.initials: M
authors.lastname: Rodenburg
authors.forename: J
authors.initials: J
authors.lastname: Blass
authors.forename: J
authors.initials: J
authors.lastname: Reidl
mesh_terms: D000818:Animals; D005294:Ferrochelatase / Q000235:genetics*; D006193:Haemophilus influenzae / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D016296:Mutagenesis; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005294:Ferrochelatase