[The effect of internal exposure to 90Sr on hematopoietic stem cells in CBA mice].
After acute intake of 90Sr the changes of d-9 CFUs number in mice (CBA) bone marrow, spleen and peripheral blood were investigated. The obtained results indicated similar quantitative changes in bone marrow and spleen CFUs on exposure to the 90Sr when radiation doses did not cause the decrease in life-time (1.11 kBq/g). Sarcomogeneous doses of 90Sr (29.6 kBq/g) resulted in drastic changes of hemopoietic system: spleen haematopoiesis activation and suppression of bone marrow functions. On the first day after 90Sr injection (29.6 kBq/g) the increase in number of peripheral blood CFUs (circulating pool) was observed.
Shibkova
D Z
DZ
Urals Research Center for Radiation Medicine, Chelyabinsk, Russia.
Andreeva
O A
OA
Tolstykh
E I
EI
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental; D013326:Strontium Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects
D013326:Strontium Radioisotopes