title: Synthesis of 4'-substituted nucleosides and their biological evaluation.
abstract: 4'-C-Ethynyl-beta-D-arabino- and 4'-C-ethynyl-beta-D-2'-deoxy-ribo-pentofuranosyl pyrimidines were synthesized. Most of these 4'-ethynyl nucleosides showed interesting biological activities.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kohgo
authors.forename: E
authors.initials: E
authors.lastname: Kodama
authors.forename: S
authors.initials: S
authors.lastname: Shigeta
authors.forename: M
authors.initials: M
authors.lastname: Saneyoshi
authors.forename: H
authors.initials: H
authors.lastname: Machida
authors.forename: H
authors.initials: H
authors.lastname: Ohrui
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000633:toxicity; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D015195:Drug Design; D006678:HIV / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007624:KB Cells; D007941:Leukemia P388; D051379:Mice; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D000964:Antimetabolites, Antineoplastic; D000998:Antiviral Agents; D007202:Indicators and Reagents; D009705:Nucleosides