title: Gabapentin "add-on therapy" for idiopathic chronic hiccup (ICH).
abstract: The efficacy of cisapride, omeprazole, and baclofen (COB) for treatment of idiopathic chronic hiccup (ICH). was proven in several studies. The combination is considered, at present, to be "therapy of choice" for this condition. Substituting gabapentin for baclofen in baclofen resistant ICH cases can occasionally be successful. We present here cases where gabapentin was used successfully in combination with cisapride and omeprazole (COG/one patient) or as an "add-on" with cisapride, omeprazole, and baclofen (COBG/three patients). We conclude that, with baclofen and gabapentin, we are in possession of two substances that are, as a part of a combination therapy, quite effective for ICH. Because of the far more extensive experience with baclofen, we use it as a first-line therapy, together with omeprazole and cisapride. In cases where the results are not entirely satisfactory, the addition of gabapentin should be considered.
authors.affiliation: Department of Pharmacology and Toxicology, University of Heidelberg at Mannheim, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Petroianu
authors.forename: G
authors.initials: G
authors.lastname: Hein
authors.forename: A
authors.initials: A
authors.lastname: Stegmeier-Petroianu
authors.forename: W
authors.initials: W
authors.lastname: Bergler
authors.forename: R
authors.initials: R
authors.lastname: Rüfer
mesh_terms: D000085:Acetates / Q000008:administration & dosage*; D000368:Aged; D000588:Amines; D001418:Baclofen / Q000008:administration & dosage*; D002908:Chronic Disease; D020117:Cisapride / Q000008:administration & dosage*; D003509:Cyclohexanecarboxylic Acids; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D000077206:Gabapentin; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006606:Hiccup / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009125:Muscle Relaxants, Central / Q000008:administration & dosage; D009853:Omeprazole / Q000008:administration & dosage*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005765:Gastrointestinal Agents; D009125:Muscle Relaxants, Central; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D001418:Baclofen; D009853:Omeprazole; D020117:Cisapride