Evaluation of the long-term function of cryopreserved ovarian grafts in the mouse, implications for human applications.
Ovarian tissue storage has several potentially very valuable clinical applications, including the management of young female patients that are at risk of premature menopause. Ovarian tissue collection, used alone or in combination with oocyte and embryo cryopreservation, may help these patients safeguard their own future fertility. All available evidence from animal studies indicates that grafting of frozen ovarian tissue should be feasible in the human. This study on the mouse shows that frozen thawed ovarian tissue grafts can restore long term fertility to previously ovariectomised recipients. This, and other available evidence, indicates that ovarian tissue collection and storage, used alone or in combination with oocyte or embryo collection, may help safeguard the fertility of patients at risk of premature menopause.
Shaw
J M
JM
Centre for Early Human Development, Monash Institute of Reproduction and Development, Clayton, Australia. jill.shaw@med.monash.edu.au
Cox
S L
SL
Trounson
A O
AO
Jenkin
G
G
D000818:Animals; D015925:Cryopreservation; D004971:Estrus; D005069:Evaluation Studies as Topic; D005260:Female; D005333:Fetus / Q000033:anatomy & histology / Q000166:cytology; D006085:Graft Survival; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D006080:Ovarian Follicle / Q000166:cytology; D010053:Ovary / Q000166:cytology / Q000637:transplantation*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014021:Tissue Preservation / Q000379:methods / Q000592:standards; D016378:Tissue Transplantation / Q000379:methods / Q000592:standards