title: Axial chirality of ortho-substituted N,N-diacylanilines: electronic effects of acyl groups on racemization
abstract: Studies on the racemization of optically active ortho-tert-butyl-N,N-diacylanilines 1c-e including the electronic effects of their acyl groups are described. The racemization of 1c bearing a 4-methoxyphenyl substituent occurred faster while that of le bearing a 4-trifluoromethylphenyl substituent was slower, compared with that of 1d bearing a phenyl group. Thus, the rate of racemization depends on the electronic effects of the acyl groups in addition to steric effects of the acyl groups in la, b as reported previously (K. Kondo, H. Fujita, T. Suzuki and Y. Murakami, Tetrahedron Lett. 1999, 40, 5577-5580).
authors.affiliation: School of Pharmaceutical Sciences, Toho University, Chiba, Japan.
authors.initials: K
authors.lastname: Kondo
authors.initials: H
authors.lastname: Fujita
authors.initials: T
authors.lastname: Suzuki
authors.initials: Y
authors.lastname: Murakami