Role of intracerebroventricular vasopressin in the development of stress-induced gastric lesions in rats.
We investigated whether arginine vasopressin (AVP) has a central influence on the development of gastric mucosal lesions evoked by restraint-cold stress in rats. AVP and vasopressin V1 receptor antagonist were injected intracerebroventricularly (i.c.v.) and the rats were exposed to restraint-cold stress for five hours. After decapitation the stomachs were examined for gastric mucosal lesions which were evaluated according to an ulcer score. Three different doses of AVP and V1 receptor antagonist were administered in order to investigate the effects of exogenous and endogenous AVP on stress-induced gastric mucosal lesions. The intensity of gastric mucosal lesions was reduced when exogenous AVP was injected intracerebroventricularly. On the other hand, vasopressin V1 receptor antagonist, which was administered by the same route, augmented gastric mucosal lesions. Our findings indicate that AVP, injected centrally, plays a role in preventing the formation of gastric mucosal lesions induced by stress via a central V1 receptor.
Büyükcoskun
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NI
Department of Physiology, Uludag University Medical Faculty, Bursa, Turkey.
Ozlük
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K
D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000494:pharmacology*; D003080:Cold Temperature; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000503:physiopathology; D007276:Injections, Intraventricular; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D013312:Stress, Physiological / Q000503:physiopathology*; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D065092:Antidiuretic Hormone Receptor Antagonists; D014662:Vasoconstrictor Agents; D001127:Arginine Vasopressin