title: The in vivo sensitivity of Plasmodium falciparum to chloroquine in the Red River basin, Yunnan, China.
abstract: The sensitivity of Plasmodium falciparum to chloroquine in vivo was examined out in a small town in the Red River basin from 1995 to 1996. forty cases were recruited into the present study, 32 cases were completely followed-up. The results of the in vivo study revealed that only 3 (9%) cases were sensitive to chloroquine, 29 (90.6%) showed resistance to chloroquine, among whom 7 cases (22%) showed resistance at RI, 12 cases (38%) at RII, and 10 cases (31%) at RIII. It is suggested that P. falciparum endemic areas should stop using chloroquine and other 4-aminoquinolines in the Red River basin now. Qinhaosu and pyronaridine were recommended to use as the first line antimalarial drugs of P. falciparum infection in the basin.
authors.affiliation: Honghe Prefecture Health and Anti-epidemic Station, Geju, Yunnan, PR China.
authors.forename: G
authors.initials: G
authors.lastname: Hong-Ping
authors.forename: Z
authors.initials: Z
authors.lastname: Yao
authors.forename: D
authors.initials: D
authors.lastname: Qian
authors.forename: Y
authors.initials: Y
authors.lastname: Jin-Hua
authors.forename: J
authors.initials: J
authors.lastname: Kai-Xun
authors.forename: Z
authors.initials: Z
authors.lastname: Min
mesh_terms: D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D002738:Chloroquine