title: Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.
abstract: A protein named nuclear receptor binding factor-2 (NRBF-2) was identified by yeast two-hybrid screening, as an interaction partner of peroxisome proliferator-activated receptor alpha as well as several other nuclear receptors. NRBF-2 exhibited a gene activation function, when tethered to a heterologous DNA binding domain, in both mammalian cells and yeast.
authors.affiliation: Department of Life Science, Himeji Institute of Technology, Hyogo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yasumo
authors.forename: N
authors.initials: N
authors.lastname: Masuda
authors.forename: T
authors.initials: T
authors.lastname: Furusawa
authors.forename: T
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: H
authors.initials: H
authors.lastname: Sadano
authors.forename: T
authors.initials: T
authors.lastname: Osumi
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D008099:Liver / Q000378:metabolism; D008969:Molecular Sequence Data; D010957:Plasmids; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D016415:Sequence Alignment; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation; D014407:Tumor Cells, Cultured
chemical_list: C504659:Nrbf2 protein, rat; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D014157:Transcription Factors