Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood.
The effect of dietary docosahexaenoic acid (DHA) on T cell states in peripheral blood was investigated. Weanling male C57Bl/6N mice were kept on one of three 10% fat diets containing various amounts of DHA and linoleic acid for 4 weeks. Changing the concentration of dietary DHA did not alter the proportion of T cells expressing CD4 or CD8. However, increasing the concentration of dietary DHA lowered the expression of CD4 and CD8 on the cell surface. The decreased expression of these surface molecules involved in T cell proliferation has serious implications in the role of DHA as an immunosuppressant.
Sasaki
T
T
Departments of Bioregulation Studies and Food Nutrition, Graduate School of Agriculture, Tokyo University of Agriculture, Setagaya, Tokyo 156-8502, Japan.
Kanke
Y
Y
Nagahashi
M
M
Toyokawa
M
M
Matsuda
M
M
Shimizu
J
J
Misawa
Y
Y
Takita
T
T
D000818:Animals; D015704:CD4 Antigens / Q000096:biosynthesis* / Q000097:blood; D016827:CD8 Antigens / Q000096:biosynthesis* / Q000097:blood; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D004281:Docosahexaenoic Acids / Q000494:pharmacology*; D019787:Linoleic Acid / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D015430:Weight Gain / Q000187:drug effects
D015704:CD4 Antigens; D016827:CD8 Antigens; D004042:Dietary Fats, Unsaturated; D004281:Docosahexaenoic Acids; D019787:Linoleic Acid