An efficient method for the synthesis of [2-(15)N]guanosine and 2'-deoxy[2-(15)N]guanosine derivatives.
Nucleophilic substitution reaction of 6-chloro-2-fluoro-9-beta-D-ribofuranosyl-9H-purine derivative, prepared from guanosine, with potassium [15N]phthalimide at 40 degrees C for 9 h in DMF, followed by hydrolysis, afforded [2-(15)N]guanosine derivative efficiently. The corresponding 2'-deoxy derivative was also synthesized through a similar procedure.
Kamaike
K
K
Laboratory of Pharmaceutical Chemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
Kinoshita
K
K
Niwa
K
K
Hirose
K
K
Suzuki
K
K
Ishido
Y
Y
D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods; D015394:Molecular Structure; D009587:Nitrogen Isotopes
D007202:Indicators and Reagents; D009587:Nitrogen Isotopes; D006151:Guanosine; D003849:Deoxyguanosine