Non-hodgkin malignant lymphoma with tissue neutrophilia: a report of 3 cases.
BACKGROUND
Neutrophils, in the absence of necrosis, are uncommon in non-Hodgkin malignant lymphoma. Recently, a neutrophil-rich type of Ki-1 (CD30)-positive, anaplastic large cell lymphoma was described.


OBJECTIVE
We report 3 cases of nonanaplastic large cell lymphoma with an abundance of tissue neutrophils; 2 cases were associated with breast carcinoma and possible infection.


RESULTS
Peripheral blood neutrophilia was noted in only 1 of these 3 patients. Neutrophilia in the lymph nodes occurred in either a sinusoidal or interstitial pattern. Multiple biopsies were available for review in 2 patients; however, tissue neutrophilia was present in only 1 biopsy each.


CONCLUSIONS
These findings suggest that nonanaplastic large cell lymphoma-related tissue neutrophilia is a transient phenomenon.
Badve
S
S
Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10467, USA.
Blumstein
A
A
Wiernik
P
P
Ratech
H
H
D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000032:analysis; D001706:Biopsy; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000473:pathology*; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000473:pathology*; D020556:Neutrophil Infiltration; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis
D015703:Antigens, CD; D019253:Proto-Oncogene Proteins c-bcl-2