title: Report on the quality of life analysis from the phase III trial of pion versus photon radiotherapy in locally advanced prostate cancer.
abstract: This report examines the quality of life (QOL) of 215 patients entered into a randomised trial between pion and photon radiotherapy for prostate cancer at a single institution. The survival and local control results of the trial were equivalent in both arms. A modification of the Rotterdam Symptom Checklist (RSCL) was used to assess QOL. Global QOL, toxicity and physical scores were found to be worse in pion-treated patients at the end of treatment (P<0.001, P<0.001, and P=0.02 respectively). There are no long-term differences in the QOL of pion- versus photon-treated patients. Sexual function was a concern for patients even at baseline. There was a progressive loss of sexual interest and erectile function. There was a significant impact from hormonal therapy at relapse. Hormonal treatment produced a stepwise significant worsening in global QOL, particularly for physical and psychological domains.
authors.affiliation: Radiation Oncology Program, British Columbia Cancer Agency, Vancouver Clinic, and University of British Columbia, 600 West 10th Avenue, Vancouver, Canada. gduncan@bccancer.bc.ca
authors.forename: G G
authors.initials: GG
authors.lastname: Duncan
authors.forename: N
authors.initials: N
authors.lastname: Philips
authors.forename: T
authors.initials: T
authors.lastname: Pickles
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000534:rehabilitation; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008651:Mesons / Q000627:therapeutic use*; D008875:Middle Aged; D017785:Photons / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000534:rehabilitation; D011594:Psychometrics; D011788:Quality of Life
chemical_list: D018931:Antineoplastic Agents, Hormonal