Inhibition of DNA topoisomerases by nidulalin A derivatives.
Three cytotoxic dihydroxanthone derivatives, nidulalin A(1), F390B(2), and F390C(3) were evaluated for inhibitory activity against DNA topoisomerases. Compounds 1 and 2 inhibited DNA topoisomerase II with IC50 values of 2.2 microM and 16 microM, and 3 inhibited DNA topoisomerase I with an IC50 value of 5.9 microM.
Sato
S
S
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc., Kawasaki, Japan.
Fukuda
Y
Y
Nakagawa
R
R
Tsuji
T
T
Umemura
K
K
Andoh
T
T
D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014970:Xanthines / Q000494:pharmacology
D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D014970:Xanthines; C114123:nidulalin A