Recognition of flexible peptides in water by transition metal complexes.
This paper describes the design, synthesis, and evaluation of transition metal complexes capable of recognizing flexible histidine-containing peptides in aqueous medium (25 mM HEPES buffer, pH = 7.0, 25 degrees C). When the pattern of metal ions on a complex matches with the pattern of histidine moieties on the peptide, strong interaction (K = 1.2 x 10(6) M-1) can be achieved. The complex was highly selective (> 200:1) in discriminating similar flexible peptides differing only by one glycine unit.
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Department of Chemistry, North Dakota State University, Fargo 58105, USA.
Abul Fazal
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Roy
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Mallik
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D005998:Glycine / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D008670:Metals; D010455:Peptides; D014867:Water; D006639:Histidine; D005998:Glycine