[Effects of human papilloma virus types on course of juvenile respiratory papillomatosis and effectiveness of interferon therapy in children].
Identification of the type of human papilloma virus (HPV) was done by means of polymerase chain reaction in 40 children with juvenile respiratory papillomatosis (JRP). Adjuvant to surgery interferon treatment was carried out in 18 patients (study group) with severe JRP. The rest 22 patients (control group) with less severe papillomatosis received only surgical treatment. The majority of the patients from both the groups had the virus type 6/11 (72.2 and 77.3% for the study and control groups, respectively). The assessment of a relationship between HPV type and effectiveness of interferon treatment in the study group has shown that the share of patients with effective and uneffective interferon therapy in each category (by HPV type) was about the same, i.e. no correlation exists between HPV type and interferon therapy effectiveness.
Nurmukhametov
R Kh
RKh
Onufrieva
E K
EK
Soldatskiĭ
Iu L
IuL
Brodskiĭ
M Iu
MIu
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004333:Drug Administration Routes; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007370:Interferon Type I / Q000008:administration & dosage / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D008297:Male; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D011994:Recombinant Proteins; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins