Synthesis of enantiomerically pure C2-symmetric 4-pyrrolidinopyridine derivative as a chiral acyl transfer catalyst for the kinetic resolution of secondary alcohols
The first chiral C2-symmetric 4-pyrrolidinopyridine (PPY) derivative was synthesized in an enantiomerically pure form and successfully utilized as a chiral nucleophilic catalyst for the kinetic resolution of secondary alcohols leaving one enantiomer with high selectivity factors (up to s = 13.5).
Naraku
G
Institute for Fundamental Research of Organic Chemistry, Kyushu University, Fukuoka, Japan.
Shimomoto
N
Hanamoto
T
Inanaga
J