Pluripotent haemopoietic progenitor cells (CFU-Sd8) in peripheral blood of hereditarily anaemic Belgrade (b/b) rats.
The unique anaemic syndrome of the Belgrade laboratory (b/b) rat is due to an intracellular iron deficiency which is induced by a not yet defined mutation, resulting in impairment of haemopoiesis. We investigated the CFU-Sd8 number and concentration in the peripheral blood of b/b rats to study the relationship between medullary and extramedullary haemopoiesis in this anaemic syndrome. The results show normal concentration of CFU-Sd8 in the peripheral blood of b/b rats. This finding was unexpected in the state of severe anaemia and disturbed growth factor production in b/b rats, where the mobilization of CFU-Sd8 from bone marrow to blood is expected. The results suggest that severe anaemia is not regularly accompanied by the mobilization of pluripotent progenitors from bone marrow to the blood.
Ivanović
Z
Z
Institute for Medical Research, Belgrade, Yugoslavia.
Milenković
P
P
D000740:Anemia / Q000209:etiology / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D003114:Colony-Forming Units Assay / Q000662:veterinary; D004906:Erythrocyte Count / Q000662:veterinary; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D017354:Point Mutation; D051381:Rats; D011913:Rats, Inbred BB / Q000502:physiology*; D013154:Spleen / Q000473:pathology; D014916:Whole-Body Irradiation / Q000662:veterinary
D006454:Hemoglobins