Synthesis and antiviral properties of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives as novel Acyclovir analogues.
This paper reports the synthesis and the antiviral properties of a series of 9-[(2-methyleneaminoxyethoxy)methyl]guanine derivatives, which can be viewed as analogues of the antiherpes drug Acyclovir (ACV) from which they differ in the replacement of its hydroxy group with variously substituted methyleneaminoxy moieties. Some of the newly synthesized compounds proved to possess a certain activity against HSV-1, albeit lower than that of ACV.
Macchia
M
M
Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy. mmacchia@farm.unipi.it
Antonelli
G
G
Calvani
F
F
Di Bussolo
V
V
Minutolo
F
F
Orlandini
E
E
Tesoro
R
R
Turriziani
O
O
D000212:Acyclovir / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D015497:HIV-1 / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014709:Vero Cells / Q000187:drug effects
D000998:Antiviral Agents; D000212:Acyclovir