Antagonists of protein-protein interactions.
Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.
Cochran
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AG
Department of Protein Engineering, Genentech, Inc., South San Francisco, CA 94080, USA. andrea@gene.com
D000595:Amino Acid Sequence; D001665:Binding Sites; D001667:Binding, Competitive; D019281:Dimerization; D015195:Drug Design; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019151:Peptide Library; D011485:Protein Binding / Q000187:drug effects*
D019151:Peptide Library