A human HP1 pseudogene maps to chromosome 11p14.
The chromo multigene superfamily encodes numerous proteins involved in chromatin structure or organization. The prototypical member of this superfamily is HP1 of Drosophila melanogaster. We now present the sequence of a human HP1Hs gamma pseudogene and assign it to chromosome 11p14 by radiation hybrid mapping. The coding regions of at least three other human genes for HP1 orthologues and another pseudogene are very similar in sequence. These results demonstrate that HP1-type sequences have been duplicated multiple times in the mammalian genome.
Park
A
A
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Holmer
L
L
Worman
H J
HJ
D001483:Base Sequence; D000090266:Chromobox Protein Homolog 5; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D004247:DNA / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D011544:Pseudogenes / Q000235:genetics*; D015183:Restriction Mapping
D002868:Chromosomal Proteins, Non-Histone; D018076:DNA, Complementary; D000090266:Chromobox Protein Homolog 5; D004247:DNA