CR3: a general purpose adhesion-recognition receptor essential for innate immunity.
CR3 (CD11b/CD18), a beta(2) integrin, has a key role in innate antimicrobial defenses, as evidenced by the leukocyte adhesion (CD18) deficiency syndrome in humans and the CD11b knockout mouse. CR3 is a highly versatile pattern-recognition receptor that activates leukocytes via signaling complexes and actin reorganization, mediates phagocytosis, and promotes leukocyte transmigration.
Ehlers
M R
MR
BioNebraska, Inc., 3820 NW 46thStreet, Lincoln, NE 68524, USA.
D000818:Animals; D006801:Humans; D007109:Immunity; D016023:Integrins / Q000235:genetics / Q000276:immunology*; D008024:Ligands; D016177:Macrophage-1 Antigen / Q000235:genetics / Q000276:immunology*; D051379:Mice; D018345:Mice, Knockout; D010587:Phagocytosis; D015398:Signal Transduction / Q000276:immunology
D016023:Integrins; D008024:Ligands; D016177:Macrophage-1 Antigen