[Significance of hereditary factors in multiple organ dysfunction syndrome in children with infections].
In order to elucidate the contribution of hereditary factor (dose of ribosome genes) to the realization of organ dysfunction syndromes in children with surgical infection, the total size of silver nitrate-stained nucleoli-forming regions (Ag-NFR) of acrocentric chromosomes in karyotypes was assessed in 22 patients aged from 14 months to 12 years, 17 of these with appendicular peritonitis, 4 with destructive pneumonia, and 1 with acute hematogenic osteomyelitis. Pyoseptic diseases involved no organ dysfunction in 10 patients, and in 12, multiple organ dysfunction was diagnosed. Our findings indicate that the carriers of low-copy variants of ribosome genes are characterized by hereditary predisposition to lowered individual resistance of the organism. Therefore, children with surgical infection with a decreased size of Ag-NFR (low dose of ribosome genes) in the karyotype potentially represent a group at risk of multiple organ dysfunction realization.
Viktorov
V V
VV
Viktorova
T V
TV
Mironov
P I
PI
Khustnutdinova
E K
EK
D002648:Child; D002675:Child, Preschool; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007621:Karyotyping; D009102:Multiple Organ Failure / Q000209:etiology / Q000235:genetics*; D010019:Osteomyelitis / Q000150:complications*; D010538:Peritonitis / Q000150:complications*; D011014:Pneumonia / Q000150:complications*; D012270:Ribosomes / Q000235:genetics