title: Simulations of the frequency response of implantable glucose sensors.
abstract: The response of enzyme electrode glucose sensors implanted in tissues to physiologic blood glucose oscillations is simulated. Models describe both oxygen-based and peroxide-based glucose sensors in spatially homogeneous medium simulating some mass transfer properties of tissue. Pass-through ratios and delays are reported as a function of frequency for the oxygen-based sensor, and the effects on continuous blood glucose monitoring are illustrated using data from the literature. Certain peroxide-based sensor designs may produce common signals for different glucose concentrations, a characteristic not found in oxygen-based sensors. The dynamic response depends on the frequency of glucose oscillation and is sensitive to sensor type, enzyme activity, and diffusional resistance.
authors.affiliation: Department of Bioengineering, University of California, San Diego, La Jolla 92093, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jablecki
authors.forename: D A
authors.initials: DA
authors.lastname: Gough
mesh_terms: D000465:Algorithms; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D003198:Computer Simulation; D008954:Models, Biological
chemical_list: D001786:Blood Glucose