T cell life and death signalling via TNF-receptor family members.
An effective immune response requires the rapid and accurate mobilisation of millions of effector cells in an antigen driven fashion. These effector cells must be kept alive long enough to fulfil their function but the majority must then be eliminated, a process known as activation-induced cell death. Recent advances in the field of lymphocyte biology have shed light onto how this balance is maintained and onto the consequences for disease if the homeostatic mechanisms become disturbed.
Screaton
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Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, OX3 9DS, UK. screaton@worf.molbiol.ox.ac.uk.
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D015703:Antigens, CD / Q000378:metabolism; D016923:Cell Death; D018448:Models, Immunological; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D047888:Receptors, Tumor Necrosis Factor, Type I; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*; D019014:fas Receptor / Q000378:metabolism
D015703:Antigens, CD; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D019014:fas Receptor