Effect of nimodipine on final infarct volume after acute ischemic stroke.
Placebo-controlled clinical trials with nimodipine in acute ischemic stroke have not fulfilled the early optimistic expectations. Nimodipine has in some experimental studies, when administered either before or up to 90 min after induction of cerebral ischemia, resulted in a reduction of infarct size. No studies on the effects of nimodipine on infarct size in man have been published. We measured the infarct volumes in the admission and control CT examinations 3 weeks to 3 months later in 153 patients who had participated in a multicenter, randomized and placebo-controlled study. No statistically significant differences overall were found within or between the treatment groups. Subgroup analyses revealed in the placebo, but not in the nimodipine arm, an increase in the median infarct volumes if the treatment was started within 24 h of onset, and if the volume in the admission CT was less than median. A beneficial effect of nimodipine in prevention of infarct size increase in these circumstances cannot be excluded.
Fogelholm
R
R
Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland. r.fogel@saunalahti.fi
Erilä
T
T
Palomäki
H
H
Murros
K
K
Kaste
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000188:drug therapy*; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D020243:Infarction, Anterior Cerebral Artery / Q000188:drug therapy; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy; D020762:Infarction, Posterior Cerebral Artery / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009553:Nimodipine / Q000627:therapeutic use*; D010919:Placebos; D014057:Tomography, X-Ray Computed; D014665:Vasodilator Agents / Q000627:therapeutic use*
D010919:Placebos; D014665:Vasodilator Agents; D009553:Nimodipine