title: Myogenic reactivity and resistance distribution in the coronary arterial tree: a model study.
abstract: The objectives of this study were to evaluate the myogenic behavior of blood vessels and their interaction within the coronary arterial tree and to evaluate the possible role of the myogenic response in autoregulation. The model consists of 10 compartments in series, each representing a class of vessel sizes. Diameter and resistance in each class are determined by their value at full dilation (d(p,) R(p)) and by the myogenic response. Three distributions of R(p) and three distributions of myogenic strength, M(i) (slope of pressure-diameter curve, range -0.05 to -0.4%/mmHg) were evaluated (9 cases). It was found that larger vessels attenuate the myogenic activity of smaller vessels and that myogenic responsiveness is sufficient to achieve autoregulation. When M(i) has a maximum in vessels of 84 microm, the maximum effect of perfusion pressure on active diameter occurs in vessels between 123 and 181 microm, depending on the distribution of R(p). Distribution of resistance and control mechanisms in the coronary arterial tree are important for interpretation of individual vessel responses as observed in vivo.
authors.affiliation: Faculty of Design, Engineering and Production, Mechanical Engineering and Marine Technology, Man Machine Systems and Control Group, Delft University of Technology, 2628 CD Delft, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cornelissen
authors.forename: J
authors.initials: J
authors.lastname: Dankelman
authors.forename: E
authors.initials: E
authors.lastname: VanBavel
authors.forename: H G
authors.initials: HG
authors.lastname: Stassen
authors.forename: J A
authors.initials: JA
authors.lastname: Spaan
mesh_terms: D000465:Algorithms; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D003331:Coronary Vessels / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D012212:Rheology; D013552:Swine; D014655:Vascular Resistance / Q000502:physiology*; D014661:Vasoconstriction / Q000502:physiology*