Meningitis carcinomatosa originating from an alpha fetoprotein-producing gastric cancer.
Alpha fetoprotein (AFP)-producing gastric cancer is relatively rare and meningitis carcinomatosa is similarly a rare manifestation among the neoplastic diseases. There have been no previous reports of meningitis carcinomatosa originating from AFP-producing gastric cancer. A 68-year-old man with AFP-producing gastric cancer was treated with cisplatin and doxifluridine because of multiple liver metastases. Although the liver lesion was reduced to 30% of pretreatment size after 6 courses of chemotherapy, meningitis carcinomatosa subsequently occurred. Immunostaining of AFP and magnetic resonance imaging (MRI) were useful in the diagnosis of meningitis caused by AFP producing cancer cells.
Tsujikawa
T
T
Second Department of Internal Medicine, Shiga University of Medical Science, Otsu.
Tsukamoto
H
H
Itoh
A
A
Andoh
A
A
Sasaki
M
M
Koyama
S
S
Fujiyama
Y
Y
Bamba
T
T
D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D017809:Fatal Outcome; D005773:Gastroscopy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism / Q000556:secondary; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary*; D008581:Meningitis / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D000509:alpha-Fetoproteins