The role of taurine in neuronal protection following transient global forebrain ischemia.
Osmoregulation and post ischemic glutamate surge suppression (PIGSS) are important mechanisms in the neuroprotective properties of taurine. We studied the role of taurine in PIGSS following transient global forebrain ischemia (TGFI). A group of gerbils received a high dose of continuous intracerebral taurine during the peri-ischemic period. Beta-alanine was given similarly to a negative control group. The control group consisted of animals undergoing only TGFI. On the fourth day following commencement of drug administration, TGFI was induced. Concurrently, half the animals from each group receiving an agent had intracerebral microdialysis. All animals underwent histological assessment at day 7. The microdialysis and histological data was analyzed. Our results showed that taurine treatment did not cause PIGSS. The histological difference between the three groups was statistically insignificant. We conclude that intracerebral taurine in the dosage administered during peri-ischemic period, does not result in PIGSS or histologically evident neuroprotection.
Khan
S H
SH
Saskatchewan Stroke Research Centre, University of Saskatchewan, Saskatoon, Canada.
Banigesh
A
A
Baziani
A
A
Todd
K G
KG
Miyashita
H
H
Eweida
M
M
Shuaib
A
A
D000818:Animals; D005849:Gerbillinae; D002546:Ischemic Attack, Transient / Q000473:pathology*; D008297:Male; D017551:Microdialysis; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D016548:Prosencephalon / Q000473:pathology*; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine