title: Integrins: regulators of embryogenesis.
abstract: Integrins are heterodimeric transmembrane glycoproteins involved in cell-cell and cell-extracellular matrix adhesion. They also participate in cytoskeletal rearrangements, co-regulation of growth factor activities and activation of signal transductions. This review describes experimental approaches that have given new insights into the integrin functions during embryogenesis. Using anti-functional antibodies, peptide inhibitors of integrin-ligand interactions and genetic ablation of integrins results, this review will show that integrins are key molecules during early development of both invertebrates and vertebrates.
authors.affiliation: Université P.-et-M.-Curie, U.M.R.-CNRS 7622, Laboratoire de Biologie Moléculaire et Cellulaire du Développement, Equipe Adhesion et Migration Cellulaires, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Darribère
authors.forename: M
authors.initials: M
authors.lastname: Skalski
authors.forename: H L
authors.initials: HL
authors.lastname: Cousin
authors.forename: A
authors.initials: A
authors.lastname: Gaultier
authors.forename: C
authors.initials: C
authors.lastname: Montmory
authors.forename: D
authors.initials: D
authors.lastname: Alfandari
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D004622:Embryo, Mammalian / Q000166:cytology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*
chemical_list: D016023:Integrins