Comparative study of D-002 versus sulfasalazine on acetic acid-induced colitis in rats.
D-002 is a natural mixture of higher aliphatic primary alcohols purified from beeswax and has experimentally proven mild antiinflammatory and effective antiulcer effects. It reduces leukotrienes in the exudate of carrageenan-induced pleurisy and has a protective effect on the preulcerative phase of carrageenan-induced colonic ulceration in the guinea pig. This study was conducted to compare the effect of D-002 and sulfasalazine on acetic acid-induced colitis in rats administered at 1, 5.25 and 100 mg kg-1, 24 h before colitis induction. Significant reductions in wet weight, macroscopic injury, polymorphonuclear infiltration and wall thickness were observed in the colonic mucosa of D-002 and sulfasalazine-treated animals compared with controls, except at the dose of 1 mg kg-1. It was concluded that the effects of D-002 and sulfasalazine were comparable in this experimental model.
Noa
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Department of Pharmacology, National Center for Scientific Research, Havana, Cuba. dalmer@ip.etecsa.cu
Carbajal
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Molina
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Valdés
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Más
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D019342:Acetic Acid; D000818:Animals; D003092:Colitis / Q000188:drug therapy* / Q000473:pathology; D005233:Fatty Alcohols / Q000627:therapeutic use*; D007975:Leukotriene B4 / Q000032:analysis; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012460:Sulfasalazine / Q000627:therapeutic use*
C104511:D 002; D005233:Fatty Alcohols; D007975:Leukotriene B4; D012460:Sulfasalazine; D019342:Acetic Acid