title: Initial 17beta-estradiol dose for treating vasomotor symptoms.
abstract: OBJECTIVE
  To compare the efficacy of different doses of 17beta-estradiol (E2) for relief of vasomotor symptoms in menopausal women.
  
  
  METHODS
  This was a randomized, double-masked, placebo-controlled, 12-week study in which 333 menopausal women with moderate or severe hot flushes were assigned to treatment with 0.25 mg, 0.5 mg, 1 mg, or 2 mg oral micronized 17beta-E2, or placebo. The number and severity of hot flushes were recorded daily.
  
  
  RESULTS
  There was a significant linear correlation between increased dosage of 17beta-E2 and decreased moderate to severe hot flushes per week (P <.001). Rapid reduction in moderate to severe hot flushes was only achieved with 1 and 2 mg, showing a significant difference from placebo at week 4 (P <.05). At week 4, half the women on placebo had reduced moderate to severe hot flushes of at least 52%; the corresponding figures were 56%, 69%, 86%, and 91% for 0.25, 0.5, 1, and 2 mg, respectively. At week 12, all doses except 0.25 mg were significantly better than placebo for reducing moderate to severe hot flushes (P <.001). Although there were no significant differences, twice as many women in the 2-mg group discontinued treatment due to adverse events, compared with the placebo group.
  
  
  CONCLUSIONS
  Oral micronized 17beta-E2 showed a dose-response effect for reducing moderate and severe hot flushes in menopausal women. 17beta-E2 1 mg appeared to be the most useful initial dose.
authors.affiliation: Women's Medical and Diagnostic Center, The Climacteric Clinic, Gainesville, Florida, USA.
authors.forename: M
authors.initials: M
authors.lastname: Notelovitz
authors.forename: J P
authors.initials: JP
authors.lastname: Lenihan
authors.forename: M
authors.initials: M
authors.lastname: McDermott
authors.forename: I J
authors.initials: IJ
authors.lastname: Kerber
authors.forename: N
authors.initials: N
authors.lastname: Nanavati
authors.forename: J
authors.initials: J
authors.lastname: Arce
mesh_terms: D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008593:Menopause; D008875:Middle Aged
chemical_list: D004958:Estradiol