Luteinizing hormone releasing hormone increases proliferation of meningioma cells in vitro.
The fact that meningioma shows at least a 2:1 predilection for women over men is considered to be due to endocrinological and paracrine regulation of the development of this tumour. The presence of receptors for the luteinizing hormone releasing hormone (LHRH) in gynaecological cancer permits the use of LHRH agonistic or antagonistic analogues with a direct effect or by the gonado-pituitary axis suppression in the treatment of these tumours. Therefore, the effect of LHRH on meningioma cells is tested in this study. Meningioma cells from three female patients were cultured and LHRH (50 ng/ml) was added to the growth medium daily, for fourteen days. At the end of this period the cells were counted by means of a Coulter Counter. The stimulating effects of LHRH on the increase of the amount of cells in the meningioma monolayer culture were 146% (p < 0.01), 134% (p < 0.05) and 141% (p < 0.05) of the control, respectively, for the three patients.
Durmaz
R
R
Department of Neurosurgery, Medical Faculty of Osmangazi University, Eskisehir, TR-26480, Turkey. rdurmaz@ogu.edu.tr
Deliorman
S
S
Işiksoy
S
S
Uyar
R
R
Tel
E
E
D002455:Cell Division / Q000187:drug effects; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology; D011966:Receptors, LHRH / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D011966:Receptors, LHRH