Eosinophils are neither migrated nor activated in the skin lesions of atopic dermatitis in infants.
Eosinophils and eosinophil cationic protein (ECP) were examined in the skin lesions of 10 infants with atopic dermatitis (aged 4 months to 7 years). In all 10 patients, neutrophils and eosinophils were rarely seen in these lesions. Moreover, in the immunohistochemical study, ECP was scarcely detected in any of them. Our results suggest that eosinophils are neither migrated nor activated in the skin in atopic dermatitis in infants.
Kondo
N
N
Department of Pediatrics, Gifu University School of Medicine, Japan.
Shinoda
S
S
Fukutomi
O
O
Agata
H
H
Terada
T
T
Shikano
H
H
Montaño
A M
AM
Sakaguchi
H
H
Watanabe
M
M
Komiyama
K
K
Yokoyama
Y
Y
Morimoto
N
N
D001798:Blood Proteins / Q000032:analysis*; D002465:Cell Movement / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D018836:Inflammation Mediators / Q000032:analysis*; D008297:Male; D012260:Ribonucleases; D012867:Skin / Q000737:chemistry / Q000276:immunology / Q000473:pathology
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D012260:Ribonucleases