Familial risk of overweight and obesity in the Canadian population using the WHO/NIH criteria.
OBJECTIVE
To determine the familial risk of overweight and obesity in Canada.


METHODS
The sample was comprised of 15,245 participants from 6377 families of the Canada Fitness Survey. The risk of overweight and obesity among spouses and first-degree relatives of individuals classified as underweight, normal weight, pre-obese, or obese (Class I and II) according to the WHO/NIH guidelines for body mass index (BMI) was determined using standardized risk ratios.


RESULTS
Spouses and first-degree relatives of underweight individuals have a lower risk of overweight and obesity than the general population. On the other hand, the risk of Class I and Class II obesity (BMI 35 to 39.9 kg/m2) in relatives of Class I obese (BMI 30 to 34.9 kg/m2) individuals was 1.84 (95% CI: 1.27, 2.37) and 1.97 (95% CI: 0.67, 3.25), respectively, in spouses, and 1.44 (95% CI:1.10, 1.78) and 2.05 (95% CI: 1.37, 2.73), respectively in first-degree relatives. Further, the risk of Class II obesity in spouses and first-degree relatives of Class II obese individuals was 2.59 (95% CI: -0.91, 6.09) and 7.07 (95% CI: 1.48, 12.66) times the general population risk, respectively.


CONCLUSIONS
There is significant familial risk of overweight and obesity in the Canadian population using the BMI as an indicator. Comparison of risks among spouses and first-degree relatives suggests that genetic factors may play a role in obesity at more extreme levels (Class II obese) more so than in moderate obesity.
Katzmarzyk
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Department of Kinesiology and Health Science, York University North York, Ontario, Canada. katzmarz@yorku.ca
Pérusse
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Rao
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Bouchard
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D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002170:Canada; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009316:National Institutes of Health (U.S.); D009765:Obesity / Q000235:genetics*; D010809:Physical Fitness; D012307:Risk Factors; D014481:United States; D014944:World Health Organization