Fast repair of dAMP radical anions by phenylpropanoid glycosides and their analogs.
Repair effect on 2'-deoxyadenosine-5'-monophosphate (dAMP) radical anions by phenylpropanoid glycosides (PPGs) and their analogs, isolated from Chinese folk medicinal herb, was studied using pulse radiolysis technique. The radical anion of dAMP was formed by the reaction of hydrated electron with dAMP. On pulse irradiation of nitrogen-saturated dAMP aqueous solution containing 0.2 M t-BuOH and one of PPGs or their analogs, the transient absorption spectrum of the radical anion of dAMP decayed with the formation of that of the radical anion of PPGs or their analogs within several decades of microseconds after electron pulse irradiation. The results indicated that dAMP radical anions can be repaired by PPGs or their analogs. The rate constants of the repair reactions were deduced to be 1.6-4.5 x 10(8) M(-1) s(-1).
Shi
Y
Y
Department of Biology, Lanzhou University, Lanzhou 730000, China.
Wang
W
W
Fan
B
B
Jia
Z
Z
Yao
S
S
Zheng
R
R
D000838:Anions; D000975:Antioxidants / Q000737:chemistry*; D004260:DNA Repair; D003838:Deoxyadenine Nucleotides / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry*; D057888:Iridoid Glucosides; D039823:Iridoids; D010636:Phenols / Q000737:chemistry*; D011675:Pulse Radiolysis; D059808:Polyphenols
D000838:Anions; D000975:Antioxidants; D003838:Deoxyadenine Nucleotides; D016166:Free Radical Scavengers; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D010636:Phenols; C070619:pedicularioside A; C058956:acteoside; D059808:Polyphenols; C012873:2'-deoxy-5'-adenosine monophosphate