title: A general method to correct PET data for tissue metabolites using a dual-scan approach.
abstract: This article presents and analyses a general method of correcting for the presence of radiolabeled metabolites from a parent radiotracer in tissue during PET scanning. The method is based on a dual-scan approach, i.e., parent scan together with an independent supplementary scan in which the radiolabeled metabolite of interest itself is administered. The method corrects for the presence of systemically derived radiolabeled metabolite delivered to the tissues of interest through the blood.
  
  
  METHODS
  Data from the supplementary scan are analyzed to obtain the tissue impulse response function for the metabolite. The time course of the radiolabeled metabolite in plasma in the parent scan is convolved with its tissue impulse response function to derive a correction term. This is not a simple subtraction technique but 1 that takes account of the different time-activity curves of the radiolabeled metabolite in the 2 scans.
  
  
  RESULTS
  The method, its implications, and its limitations are discussed with respect to [11C]thymidine and its principal metabolite 11CO2.
  
  
  CONCLUSIONS
  The general method, based on a dual-scan approach, can be used to correct for radiolabeled metabolites in tissues of interest during PET scanning. The correction accounts for radiolabeled metabolites that are derived systemically and delivered to the tissues of interest through the blood.
authors.affiliation: MRC Cylotron Unit, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom.
authors.forename: R N
authors.initials: RN
authors.lastname: Gunn
authors.forename: J T
authors.initials: JT
authors.lastname: Yap
authors.forename: P
authors.initials: P
authors.lastname: Wells
authors.forename: S
authors.initials: S
authors.lastname: Osman
authors.forename: P
authors.initials: P
authors.lastname: Price
authors.forename: T
authors.initials: T
authors.lastname: Jones
authors.forename: V J
authors.initials: VJ
authors.lastname: Cunningham
mesh_terms: D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging; D013936:Thymidine / Q000493:pharmacokinetics; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D002250:Carbon Radioisotopes; D002245:Carbon Dioxide; D013936:Thymidine