title: [Amoxicillin/clavulanic acid in therapy of bacterial infections of the diabetic foot. Results of an observational study].
abstract: The results of an observational study of amoxicillin/clavulanic acid (Augmentan) in 191 patients are presented. The average duration of treatment was 15 days (median). Healing or improvement was observed in 76% of the cases. In view of the fact that the condition often has a multifactorial genesis and neural and vascular changes impair healing, this result must be considered a clinical success. Variables with an influence on the efficacy of the treatment were the incidence of manifestation and pathogenesis of the ulcer, renal function, blood pressure and smoking. Amoxicillin/clavulanic acid was well tolerated, with adverse events being observed in only 9 out of 193 patients (4.7%). Treatment was abandoned because of adverse events in 3 out of 193 patients (1.6%). Overall, treatment of the infected diabetic foot with amoxicillin/clavulanic acid was well tolerated and effective.
authors.affiliation: SmithKline Beecham Pharma GmbH, München.
authors.forename: V
authors.initials: V
authors.lastname: Gerards
authors.forename: U
authors.initials: U
authors.lastname: Schiewe
authors.forename: H H
authors.initials: HH
authors.lastname: Gerards
authors.forename: K
authors.initials: K
authors.lastname: Machka
authors.forename: W
authors.initials: W
authors.lastname: Höbel
authors.forename: W
authors.initials: W
authors.lastname: Meister
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D017719:Diabetic Foot / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination