title: Treatment of depression related to recurrence: 10-year follow-up in general practice.
abstract: OBJECTIVE
  To study outcomes related to long-term treatment of depression and differences in treatments for first episodes of depression in patients with and without recurrences.
  
  
  METHODS
  A historic cohort design study with 222 general practice patients who had been followed up for 10 years after being diagnosed of depression. Prescriptions for antidepressants, psychotropics and referrals over the period of 10 years following the first diagnosis of depression were studied.
  
  
  RESULTS
  Over the 10-year period, the length of treatment with antidepressants and the doses prescribed were low compared to what is known to be efficacious in depression. This was also true for treatment during the first episode. Patients with a recurrent type of illness were more often treated with antidepressants and other psychotropics during their first episode than patients with only one episode of depression, but they were not referred any more often.
  
  
  CONCLUSIONS
  Even though treatment was not as recommended for depression, the majority of the patients did not have recurrences. Future prospective research is needed to study causal relationships between treatment of depression and long-term outcome.
authors.affiliation: Department of General Practice and Social Medicine, University of Nijmegen, The Netherlands. E.vanWeel@hsv.kun.nl
authors.forename: E M
authors.initials: EM
authors.lastname: van Weel-Baumgarten
authors.forename: W J
authors.initials: WJ
authors.lastname: van den Bosch
authors.forename: Y A
authors.initials: YA
authors.lastname: Hekster
authors.forename: H J
authors.initials: HJ
authors.lastname: van den Hoogen
authors.forename: F G
authors.initials: FG
authors.lastname: Zitman
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D003866:Depressive Disorder / Q000188:drug therapy*; D005194:Family Practice; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011613:Psychotherapy; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents