Antipentylenetetrazol action of clobazam in developing rats.
Clobazam (0.5 to 7.5 mg/kg i.p.) was tested against motor seizures elicited by pentylenetetrazol in rats 7, 12, 18, 25 and 90 days old. Minimal, predominantly clonic seizures with preserved righting ability were reliably induced by pentylenetetrazol and suppressed by clobazam in rats aged 18 days or more. The incidence of minimal seizures after clobazam pretreatment was not increased in 7- and 12-day-old rat pups. Generalized tonic-clonic seizures were markedly suppressed by clobazam in all age groups. In 18-day-old and older animals clobazam doses suppressing generalized seizures were always lower than those necessary for exerting an effect on minimal seizures. The differences in clobazam action appearing at various levels of maturation are only quantitative.
Haugvicová
R
R
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Kubová
H
H
Mares
P
P
D000367:Age Factors; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000494:pharmacology*; D001569:Benzodiazepines; D001921:Brain / Q000254:growth & development* / Q000503:physiopathology*; D000078306:Clobazam; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D003292:Convulsants; D001569:Benzodiazepines; D000078306:Clobazam; D010433:Pentylenetetrazole