Synthesis and properties of novel antisense oligonucleotides bearing an anthraquinone moiety at an internucleotide linkage.
Antisense oligonucleotides bearing an anthraquinone moiety at an internucleotide linkage were synthesized utilizing the stereoisomers of anthraquinone incorporated T-C dimer phosphoramidite derivatives. Some physicochemical properties of the anthraquinon bearing oligomers were investigated.
Miyashita
T
T
Chemistry Lab., Yamasa Corporation, Choshi, Chiba, Japan.
Mori
K
K
Shinozuka
K
K
D000880:Anthraquinones; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D007202:Indicators and Reagents; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013873:Thionucleotides
D000880:Anthraquinones; D007202:Indicators and Reagents; D020319:Oligodeoxyribonucleotides, Antisense; D013873:Thionucleotides; D012313:RNA; D004247:DNA