title: Sensory-specific satiety-related olfactory activation of the human orbitofrontal cortex.
abstract: When a food is eaten to satiety, its reward value decreases. This decrease is usually greater for the food eaten to satiety than for other foods, an effect termed sensory-specific satiety. In an fMRI investigation it was shown that for a region of the orbitofrontal cortex the activation produced by the odour of the food eaten to satiety decreased, whereas there was no similar decrease for the odour of a food not eaten in the meal. This effect was shown both by a voxel-wise SPM contrast (p <0.05 corrected) and an ANOVA performed on the mean percentage change in BOLD signal in the identified clusters of voxels (p <0.006). These results show that activation of a region of the human orbitofrontal cortex is related to olfactory sensory-specific satiety.
authors.affiliation: Department of Experimental Psychology, University of Oxford.
authors.forename: J
authors.initials: J
authors.lastname: O'Doherty
authors.forename: E T
authors.initials: ET
authors.lastname: Rolls
authors.forename: S
authors.initials: S
authors.lastname: Francis
authors.forename: R
authors.initials: R
authors.lastname: Bowtell
authors.forename: F
authors.initials: F
authors.lastname: McGlone
authors.forename: G
authors.initials: G
authors.lastname: Kobal
authors.forename: B
authors.initials: B
authors.lastname: Renner
authors.forename: G
authors.initials: G
authors.lastname: Ahne
mesh_terms: D004435:Eating / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D009833:Olfactory Pathways / Q000033:anatomy & histology* / Q000502:physiology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology* / Q000502:physiology*; D018035:Receptors, Odorant / Q000502:physiology; D012201:Reward; D012527:Satiation / Q000502:physiology*; D012903:Smell / Q000502:physiology*
chemical_list: D018035:Receptors, Odorant