title: Unusual intrafusal fibres in human muscle spindles.
abstract: We have studied the morphology and pattern of expression of myosin heavy chain (MHC) isoforms of intrafusal fibres in a human first lumbrical muscle. Each intrafusal fibre type, namely nuclear bag1, nuclear bag2 and nuclear chain fibres, had a distinct MHC composition and distribution of different MHC isoforms along the whole length of intrafusal fibres. However, most muscle spindles analyzed also contained one or several intrafusal fibres exhibiting an extrafusal or mixed pattern of immunoreactivity which did not correspond to any of the described intrafusal fibre types. We conclude that the latter fibres do not represent new intrafusal fibre types, but their morphology and expression of MHC merely reflects the differences in their innervation owing to their unusual localization at the edge or outside the axial bundle of intrafusal fibres.
authors.affiliation: Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. tmsoukup@biomed.cas.cz
authors.forename: T
authors.initials: T
authors.lastname: Soukup
authors.forename: L E
authors.initials: LE
authors.lastname: Thornell
mesh_terms: D000328:Adult; D006801:Humans; D007150:Immunohistochemistry; D007536:Isomerism; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000737:chemistry / Q000473:pathology*; D018657:Muscle Fibers, Slow-Twitch / Q000737:chemistry / Q000473:pathology*; D009470:Muscle Spindles / Q000473:pathology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000473:pathology; D018995:Myosin Heavy Chains / Q000032:analysis / Q000737:chemistry
chemical_list: D018995:Myosin Heavy Chains