title: Metal ion-directed DNA recognition by chelating DNA ligands.
abstract: Novel DNA ligand bearing oxine and pyridinium group has been synthesized. The DNA binding of this ligand was regulated by coexisting Cu2+ over the range of more than three orders in magnitude of binding constant. This should be due to the metal-mediated dimerization of the ligand and concomitant emergence of cationic charges. There were definite two DNA binding modes for the ligand dimer depending on the P/L ratio.
authors.affiliation: Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kumamoto University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ihara
authors.forename: T
authors.initials: T
authors.lastname: Ikegami
authors.forename: S
authors.initials: S
authors.lastname: Sueda
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: A
authors.initials: A
authors.lastname: Jyo
mesh_terms: D002614:Chelating Agents; D002942:Circular Dichroism; D003300:Copper; D004247:DNA / Q000737:chemistry*; D019281:Dimerization; D008024:Ligands; D009690:Nucleic Acid Conformation; D015125:Oxyquinoline; D011726:Pyridinium Compounds
chemical_list: D002614:Chelating Agents; D008024:Ligands; D011726:Pyridinium Compounds; D015125:Oxyquinoline; D003300:Copper; D004247:DNA