Combinatorial approach to development of peptides that recognize DNA tetraloops.
We report recognition system for DNA tetraloops (dA1G2G3C4T5T6C7G8G9C10C11T12 (core) and dAGGCTTCGGCCT (AP2); X = abasic nucleotide) by peptides selected with combinatorial chemistry. As a result, peptides with Thr/Glu/His and Gln/Asp were obtained in binding of DNA core and AP2, respectively.
Sugimoto
N
N
Department of Chemistry, Faculty of Science, Konan University, Kobe, Japan.
Okabe
S
S
Yoneyama
M
M
D000596:Amino Acids; D020029:Base Pairing; D001483:Base Sequence; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D013816:Thermodynamics
D000596:Amino Acids; D009838:Oligodeoxyribonucleotides; D019151:Peptide Library; D010455:Peptides; D004247:DNA