title: Synthesis of a cyanopeptide-analogue with trypsin activating properties.
abstract: An efficient synthesis of a peptidic analogue of cyanobacterial metabolites with proposed serine protease inhibitory activity has been developed. Surprisingly, one trypsin activating compound was obtained.
authors.affiliation: Institute of Pharmacy, Ernst-Moritz-Arndt-University, Pharmaceutical/Medicinal Chemistry, Greifswald, Germany. radau@pharmazie.uni-greifswald.de
authors.forename: G
authors.initials: G
authors.lastname: Radau
authors.forename: D
authors.initials: D
authors.lastname: Rauh
mesh_terms: D003486:Cyanides / Q000737:chemistry; D004789:Enzyme Activation; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D014357:Trypsin / Q000378:metabolism*
chemical_list: D003486:Cyanides; D010455:Peptides; D015842:Serine Proteinase Inhibitors; D014357:Trypsin