title: Formation of 8-nitroguanine from 2'-deoxyguanosine by NO/O2 system.
abstract: We investigated the reaction of 2'-deoxyguanosine (dGuo) with NO/O2 gas mixture under physiological condition and detected 8-nitroguanine, which is known as a novel DNA lesion caused by peroxynitrite (ONOO-). The yield increased with increase in the ratio of O2 and pH. The reaction mechanism is discussed.
authors.affiliation: Institute of Advanced Energy, Kyoto University, Uji, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: K
authors.initials: K
authors.lastname: Kanaori
authors.forename: K
authors.initials: K
authors.lastname: Tajima
authors.forename: T
authors.initials: T
authors.lastname: Morii
authors.forename: K
authors.initials: K
authors.lastname: Makino
mesh_terms: D003849:Deoxyguanosine; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008956:Models, Chemical; D009566:Nitrates; D009569:Nitric Oxide; D010084:Oxidation-Reduction; D010100:Oxygen
chemical_list: C095838:8-nitroguanine; D009566:Nitrates; C039642:peroxynitric acid; D009569:Nitric Oxide; D006147:Guanine; D003849:Deoxyguanosine; D010100:Oxygen