Newer concepts and approaches to neonatal brain asphyxia.
The asphyxial injury to neonate brain seems to be mediated through a cascade of biochemical events during ischaemia--reperfusion which includes excitatory amino acids, free radicals and accelerated programmed cell death (Apoptosis). The diagnosis of asphyxia requires rigorous approach based on background clinical information, certain diagnostic tests and exclusion of alternative diagnosis which may have similar clinical presentation. The treatment currently employed for the management of birth asphyxia controversial and requires critical appraisal. The future strategies for management include a number of approaches based on putative mechanism for asphyxial brain injury but they are still being evaluated as research and should not be used for clinical purposes in human newborns as yet.
Sinha
S K
SK
Division of Women and Children, South Cleveland Hospital, Middlesbrough, UK.
Singh
J
J
D017209:Apoptosis / Q000502:physiology; D001238:Asphyxia Neonatorum / Q000503:physiopathology / Q000628:therapy*; D001921:Brain / Q000098:blood supply; D001925:Brain Damage, Chronic / Q000503:physiopathology / Q000628:therapy; D018846:Excitatory Amino Acids / Q000502:physiology; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D011247:Pregnancy; D015427:Reperfusion Injury / Q000503:physiopathology / Q000628:therapy
D018846:Excitatory Amino Acids; D005609:Free Radicals