title: 99mTc-ENS ventilation scintigraphy: preliminary study in human volunteers.
abstract: Exogenous natural surfactant (ENS) labeled with (99m)Tc ((99m)Tc-ENS, 900-1110 MBq), a new radiopharmaceutical for ventilation scintigraphy, was nebulized during 3 min to five volunteers. For comparative purposes, (99m)Tc-diethylenetriamine pentaacetic acid (DTPA) was studied in the same way. (99m)Tc-ENS images were of at least the same quality as (99m)Tc-DTPA images. However, in smoking volunteers, the (99m)Tc-DTPA images show some areas that seemed to be not well-ventilated, although these areas appeared well-ventilated when the study was performed with (99m)Tc-ENS. These results suggest that (99m)Tc-ENS can be used for ventilation scintigraphy to allow the observation of some areas that cannot been visualized using (99m)Tc-DTPA as ventilation agent.
authors.affiliation: Radioisotope Laboratory, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina. gcalmano@huemul.ffyb.uba.ar
authors.forename: G
authors.initials: G
authors.lastname: Calmanovici
authors.forename: J
authors.initials: J
authors.lastname: Boccio
authors.forename: C
authors.initials: C
authors.lastname: Goldman
authors.forename: A
authors.initials: A
authors.lastname: Hager
authors.forename: T
authors.initials: T
authors.lastname: De Paoli
authors.forename: M
authors.initials: M
authors.lastname: Alak
authors.forename: O
authors.initials: O
authors.lastname: Degrossi
authors.forename: H
authors.initials: H
authors.lastname: García del Río
authors.forename: J
authors.initials: J
authors.lastname: Nicolini
authors.forename: R
authors.initials: R
authors.lastname: Caro
authors.forename: M
authors.initials: M
authors.lastname: Zubillaga
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011663:Pulmonary Surfactants; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012907:Smoking / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate
chemical_list: D015609:Organotechnetium Compounds; D011663:Pulmonary Surfactants; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate