[Experimental research on the actions of original synthetic substances on acute inflammation in laboratory animals].
There have been determined LD50 at two original synthesis substances coded S1, S2 of the class of Mannich bases and the corresponding oxime. We have study the effects of these substances upon the acute inflammation and the immunity system of the experimental animals. The animals for experiments have been white rats to which have been administered 31.25 mg/Kg body/day substance S1 and 45 mg/Kg body/day of and the substance S2. Our researches on the proinflammatory effects of the S1 and S2 substances have shown their immunomodulating capacity.
Irina
P
P
Facultatea de Medicină, Catedra de Biochimie, Universitatea de Medicină şi Farmacie Gr.T. Popa, Iaşi.
Cătălina
L
L
Cristina
G
G
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D006614:Hindlimb; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*; D010091:Oximes / Q000627:therapeutic use*; D051381:Rats
D000893:Anti-Inflammatory Agents; D009025:Morpholines; D010091:Oximes; C407910:substance S1; C407911:substance S2; D002351:Carrageenan