[Hodgkin's disease. Etiopathogenic role of Epstein-Barr virus in Tarragona].
BACKGROUND
The aim of this study is to assess the proportion of Hodgkin disease (HD) expressing Epstein-Barr virus (EBV) in our area (Tarragona-Spain).


METHODS
A retrospective study was performed on paraffin embedded HD tissues from 49 patients to examine the presence of latent membrane protein (LMP-1) by immunohistochemistry and for EBER-1 in situ hybridization.


RESULTS
Overall, EBV (EBER-1 and/or LMP positive) was expressed in 20 cases (40.8%). This percentage was higher, but not significant, in mixed cellularity, and significant higher in patients over 55 years old. No differences between sexes were observed.


CONCLUSIONS
EBV is associated with 40.8% of HD in area of Tarragona.
Bosch Príncep
R
R
Servicio de Patología, Hospital de Tortosa Verge de la Cinta, Tortosa, Tarragona. htvcap@tinet.fut.es
Alvaro Naranjo
T
T
Balanzá Roure
R
R
Salvadó Usach
M T
MT
Martínez González
S
S
Contreras Barbeta
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain