title: A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro.
abstract: A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine via a seven step sequence. The synthesis of their 6-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely-Moser rearrangement. These compounds were found to be efficient neuroprotective agents in vitro.
authors.affiliation: Laboratoire de Chimie, Analytique et Electrochimie, UMR 8638 CNRS-Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Larget
authors.forename: B
authors.initials: B
authors.lastname: Lockhart
authors.forename: P
authors.initials: P
authors.lastname: Renard
authors.forename: M
authors.initials: M
authors.lastname: Largeron
mesh_terms: D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D018696:Neuroprotective Agents