Photo-regulated duplex- and triplex-formation of the modified DNA carrying azobenzene.
The duplex- and triplex- forming activity of oligonucleotide was photo-regulated by using the isomerization of azobenzene in the side chain. When the azobenzene was isomerized from the trans-form to the cis-form by photo-irradiation, the melting temperatures of the duplex and triplex between the oligonucleotide and its complementary counterpart were significantly lowered.
Asanuma
H
H
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Japan.
Liang
X
X
Yoshida
T
T
Ito
T
T
Komiyama
M
M
D001391:Azo Compounds; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D007202:Indicators and Reagents; D007536:Isomerism; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013816:Thermodynamics
D001391:Azo Compounds; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D004247:DNA; C009850:azobenzene