title: Comparative killing rates of fluoroquinolones and cell wall-active agents.
abstract: Killing rates of fluoroquinolones, beta-lactams, and vancomycin were compared against Enterobacteriaceae, Staphylococcus aureus, pneumococci, streptococci, and Enterococcus faecalis. The times required for fluoroquinolones to decrease viability by 3 log(10) were 1.5 h for Enterobacteriaceae, 4 to 6 h for staphylococci, and >/=6 h for streptococci and enterococci. Thus, the rate of killing by fluoroquinolones is organism group dependent; overall, they killed more rapidly than beta-lactams and vancomycin.
authors.affiliation: Department of Microbiology, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA. fungtomj@bms.com
authors.forename: J C
authors.initials: JC
authors.lastname: Fung-Tomc
authors.forename: E
authors.initials: E
authors.lastname: Gradelski
authors.forename: L
authors.initials: L
authors.lastname: Valera
authors.forename: B
authors.initials: B
authors.lastname: Kolek
authors.forename: D P
authors.initials: DP
authors.lastname: Bonner
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects; D004755:Enterobacteriaceae / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects*; D024841:Fluoroquinolones; D007769:Lactams; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007769:Lactams; D014640:Vancomycin