title: The effect of hormone replacement therapy on salivary calcium concentrations in menopausal women.
abstract: Hormone replacement therapy in menopausal women is known to affect the general calcium turnover of the body. No information is available about the effects of hormone therapy on salivary electrolytes and on calcium in particular. A group of 16 healthy peri- and postmenopausal women, all recommended to start hormone replacement therapy, were studied longitudinally for 5 months. Paraffin-stimulated whole saliva was collected at baseline, at 3 and at 5 months after the onset of therapy, and analysed for calcium, sodium and potassium concentrations. In response to hormone replacement therapy, calcium concentration decreased (p = 0.037), that of sodium increased (p = 0.019), while no change was observed in the potassium concentrations during the follow-up period.
authors.affiliation: Institute of Dentistry, University of Turku, Finland.
authors.forename: L
authors.initials: L
authors.lastname: Sewón
authors.forename: M
authors.initials: M
authors.lastname: Laine
authors.forename: S
authors.initials: S
authors.lastname: Karjalainen
authors.forename: R
authors.initials: R
authors.lastname: Leimola-Virtanen
authors.forename: T
authors.initials: T
authors.lastname: Hiidenkari
authors.forename: H
authors.initials: H
authors.lastname: Helenius
mesh_terms: D000704:Analysis of Variance; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008875:Middle Aged; D009644:Norgestrel / Q000494:pharmacology*; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism; D012463:Saliva / Q000737:chemistry / Q000502:physiology; D012636:Secretory Rate / Q000187:drug effects; D018709:Statistics, Nonparametric; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D004958:Estradiol; C026264:Cyklabil; D002118:Calcium