Synthesis of oxy-peptide nucleic acids with mixed sequences.
Syntheses of N-Fmoc delta-amino acids with an ether linkage in the main chain and six different nucleobases on the side chain, Fmoc-NH-C*H(CH2-CH2-B)-CH2-O-CH2-COOH (B = N6-benzoyladenine, thymine, uracil, N-benzoylcytosine, guanine, and N2-isobutyrylguanine) are described. The delta-amino acids were prepared through 8-12 step synthesis starting from L-homoserine and could be linked together to form novel peptide nucleic acids (oxy-PNAs = OPNAs) by solid-phase peptide synthesis.
Kuwahara
M
M
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Japan.
Arimitsu
M
M
Sigeyasu
M
M
Sisido
M
M
D007202:Indicators and Reagents; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D011687:Purines; D011743:Pyrimidines; D013237:Stereoisomerism
D007202:Indicators and Reagents; D009842:Oligopeptides; D020135:Peptide Nucleic Acids; D011687:Purines; D011743:Pyrimidines