title: Disoxaril-related 3-(diethylamino)-5-phenylisoxazoles.
abstract: Previous research has shown that 3-(dialkylamino)-5-phenylisoxazoles possessing a compact structure were active against HRV-2 and, consequently, presented a type B activity. In this paper, 3-(diethylamino)-5-phenylisoxazoles, which are structurally more elongated and related to Disoxaril, were synthesized in view to attempt type A activity against HRV-14. Unfortunately, all tested compounds were devoid of activity against HRV-14 (and HIV-1) or exhibited great toxicity.
authors.affiliation: Department of Pharmaceutical Sciences, University of Genova, Italy. mazzei@ermes.cba.unige.it
authors.forename: M
authors.initials: M
authors.lastname: Mazzei
authors.forename: R
authors.initials: R
authors.lastname: Dondero
authors.forename: B
authors.initials: B
authors.lastname: Ledda
authors.forename: F
authors.initials: F
authors.lastname: Demontis
authors.forename: L
authors.initials: L
authors.lastname: Vargiu
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D015497:HIV-1 / Q000187:drug effects; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D012229:Rhinovirus / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D007555:Isoxazoles; C045978:disoxaril