Comparison of risk of orthostatic hypotension in elderly depressed hypertensive women treated with nortriptyline and thiazides versus elderly depressed normotensive women treated with nortriptyline.
This is a nonblind, case-controlled study comparing the risk of orthostatic hypotension (OH) in 2 groups of elderly depressed women: 22 normotensive and 21 hypertensive patients receiving thiazides. Blood pressure measurements and tilt-table tests produced similar results: increased drop in systolic blood pressure (SBP) after standing (p <0.001), with no significant differences between the groups (p = 0.523). There were no changes on diastolic blood pressure (DBP) after standing, or in SBP or DBP at rest. Dizziness was reported by 23 subjects (53.5%) before treatment, and by 16 subjects (38.1%) at week 8. Complaints of dizziness were not associated with OH (Kappa = 0.07).
Scalco
M Z
MZ
Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, Brazil. mscalco@nvcet.com.br
de Almeida
O P
OP
Hachul
D T
DT
Castel
S
S
Serro-Azul
J
J
Wajngarten
M
M
D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects; D016022:Case-Control Studies; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D008875:Middle Aged; D009661:Nortriptyline / Q000009:adverse effects*; D018667:Tilt-Table Test
D000929:Antidepressive Agents, Tricyclic; D009661:Nortriptyline