Synthesis of telomere-mimic carbocyclic 5'-nor oligodeoxynucleotides.
Telomere-mimic S-ODNs have been synthesized and examined their effects on the proliferation of human tumor cell lines by XTT assay. Furthermore, the guanosine derivatives of carbocyclic 5'-nor nucleoside were synthesized.
Koga
M
M
Department of Applied Chemistry, Faculty of Engineering, Ehime University, Matsuyama, Japan.
Shigeta
M
M
Uchida
T
T
Ueda
M
M
Ohnuma
T
T
Suzuki
T
T
Saeki
T
T
D000146:Acids, Carbocyclic; D000970:Antineoplastic Agents / Q000633:toxicity; D001483:Base Sequence; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis* / Q000633:toxicity; D016615:Telomere; D013873:Thionucleotides; D014407:Tumor Cells, Cultured
D000146:Acids, Carbocyclic; D000970:Antineoplastic Agents; D020319:Oligodeoxyribonucleotides, Antisense; D013873:Thionucleotides