Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease.
Originally suggested to function mainly in inflammatory situations, recent data have implied important roles for the cyclooxygenase-2 isoenzyme in reproductive biologic processes, renal and neurologic function, and the antithrombotic activities of endothelial cells. As cyclooxygenase-2-specific inhibitors have recently become available as analgesic and anti-inflammatory drugs, a comprehensive view of this rapidly evolving field is necessary to anticipate both the potential therapeutic benefits and toxic effects associated with these agents.
Lipsky
P E
PE
University of Texas Southwestern Medical Center, Dallas 75235-8884, USA. peter.lipsky@email.swmed.edu
Brooks
P
P
Crofford
L J
LJ
DuBois
R
R
Graham
D
D
Simon
L S
LS
van de Putte
L B
LB
Abramson
S B
SB
D000818:Animals; D001921:Brain / Q000502:physiology; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D004068:Digestive System Physiological Phenomena; D005260:Female; D005836:Genitalia, Female / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism / Q000502:physiology*; D007668:Kidney / Q000502:physiology; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism / Q000502:physiology*; D013927:Thrombosis / Q000503:physiopathology
D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases