title: Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors.
abstract: A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Rutgers, The State University of Nerw Jersey, Piscataway 08854-8020, USA.
authors.forename: S
authors.initials: S
authors.lastname: Jin
authors.forename: J S
authors.initials: JS
authors.lastname: Kim
authors.forename: S P
authors.initials: SP
authors.lastname: Sim
authors.forename: A
authors.initials: A
authors.lastname: Liu
authors.forename: D S
authors.initials: DS
authors.lastname: Pilch
authors.forename: L F
authors.initials: LF
authors.lastname: Liu
authors.forename: E J
authors.initials: EJ
authors.lastname: LaVoie
mesh_terms: D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D013057:Spectrum Analysis; D059004:Topoisomerase I Inhibitors
chemical_list: D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D059004:Topoisomerase I Inhibitors