Lipoprotein(a) status in coronary heart disease.
OBJECTIVE
To compare the magnitude of lipid, and lipoproteins, especially the lipoprotein(a) [Lp(a)], in controls and patients with coronary heart disease (CHD).


METHODS
Serum total cholesterol, triglyceride, HDL-C, LDL-C, VLDL-C, apo A1, apo B, and Lp(a) levels were determined in 37 patients with CHD and 25 age matched control subjects.


RESULTS
A significant difference (P < 0.001) in lipid and apolipoprotein ratios were found. Lp(a) and other lipid parameters were found significantly high (P < 0.001) with the exception of HDL-C and apo B which were significantly low (P < 0.001) in CHD patients.


CONCLUSIONS
Elevated levels of Lp(a) suggest not only its role in atherogenesis, leading to CHD, but also that Lp(a) should be given due consideration while assessing CHD risk.
Khan
M A
MA
Department of Biochemistry, Jinnah Postgraduate Medical Centre, Karachi.
Baseer
A
A
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000401:mortality; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors
D008055:Lipids; D017270:Lipoprotein(a); D002784:Cholesterol