Putting priming into perspective - from cellular heterogeneity to cellular plasticity.
The concept of priming is widely used in cell biology and has come to mean the functional enhancement of a given cell by cytokines. 'Primed' cells have a number of other cellular alterations, although the relationship between functional and phenotypical diversity has not been established. Here, Claus Kroegel and colleagues discuss the dynamic nature of inflammatory-cell priming, which might be part of a broader means of comprehending cell function in disease.
Kroegel
C
C
Pneumology, Department IV, Medical University Clinics, Friedrich-Schiller University, Erlanger Allee 101, D-07747 Jena, Germany. kroegel@polkim.med.uni-jena.de
Foerster
M
M
Häfner
D
D
Grahmann
P R
PR
Warner
J A
JA
Braun
R
R
D015815:Cell Adhesion Molecules / Q000494:pharmacology; D002454:Cell Differentiation; D048429:Cell Size; D016207:Cytokines / Q000276:immunology / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology*; D010641:Phenotype
D015815:Cell Adhesion Molecules; D016207:Cytokines