title: [Van Der Knaap syndrome. Megalencephaly with leukodystrophy. Report of 2 cases in the same family].
abstract: We report on two brothers, aged four and six years-old, evidencing the Van Der Knaap syndrome. Clinical and radiological aspects are discussed as well their peculiarities. Data are compared with related literature, as etiopathogenic mechanisms possibly involved.
authors.affiliation: Departamento de Neurologia e Neurocirurgia, Centro Médico Maranhense.
authors.forename: C E
authors.initials: CE
authors.lastname: Cavalcanti
authors.forename: A
authors.initials: A
authors.lastname: Nogueira
mesh_terms: D001921:Brain / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D005190:Family; D020271:Heredodegenerative Disorders, Nervous System / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013577:Syndrome