Dystonia in a patient treated with propranolol and gabapentin.
We present a 68-year-old patient with essential tremor who was treated with propranolol hydrochloride (80 mg daily) and gabapentin (900 mg daily) after a history of mild success of gabapentin alone in relieving his symptoms. The patient had several daily episodes of paroxysmal dystonic movements in both hands. After reducing the propranolol dose to 40 mg daily, the dystonic movements resolved. This case suggests a synergistic effect between propranolol and gabapentin.
Palomeras
E
E
Unit of Neurology, Hospital de Mataró, Spain. neurologia2@csm.scs.es
Sanz
P
P
Cano
A
A
Fossas
P
P
D000085:Acetates / Q000009:adverse effects*; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000368:Aged; D000588:Amines; D000978:Antiparkinson Agents / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids; D004357:Drug Synergism; D004421:Dystonia / Q000139:chemically induced*; D020329:Essential Tremor / Q000188:drug therapy; D000077206:Gabapentin; D006801:Humans; D008297:Male; D011433:Propranolol / Q000009:adverse effects*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000319:Adrenergic beta-Antagonists; D000588:Amines; D000978:Antiparkinson Agents; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D011433:Propranolol