Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia.
A series of neuroleptic agents and their structural isomers have been tested as inhibitors of HIV-replication. At non-toxic concentrations, cis (Z)- and trans (E)-flupentixol and several derivatives of the 5HT-uptake-inhibitors paroxetine and femoxetine, inhibit HIV-1 replication. The findings indicated that these compounds could be used in combination with other anti-retroviral therapy in HIV-1 infected patients with AIDS-related dementia.
Kristiansen
J E
JE
Department of Clinical Microbiology, County of Sønderjylland, 6400 Sønderborg, Sygehus, Denmark.
Hansen
J B
JB
D000911:Antibodies, Monoclonal; D000928:Antidepressive Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002460:Cell Line; D005475:Flupenthixol / Q000494:pharmacology; D015683:Gene Products, gag / Q000276:immunology; D015488:HIV Antigens / Q000276:immunology; D016655:HIV Core Protein p24 / Q000276:immunology; D015497:HIV-1 / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D017374:Paroxetine / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D014764:Viral Proteins; D014779:Virus Replication / Q000187:drug effects*; D054301:gag Gene Products, Human Immunodeficiency Virus
D000911:Antibodies, Monoclonal; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D015683:Gene Products, gag; D015488:HIV Antigens; D016655:HIV Core Protein p24; D010880:Piperidines; D014764:Viral Proteins; D054301:gag Gene Products, Human Immunodeficiency Virus; C054858:p17 protein, Human Immunodeficiency Virus Type 1; D017374:Paroxetine; C010655:femoxetine; D005475:Flupenthixol