Adequate selection of anticancer agents: a task which can be fulfilled by changing selection criteria.
An analysis of anticancer agents' selection based on the effect on tumor cell colony formation inhibition after exposure to the agent under investigation is performed. The real significance of such a method, as well as the probable negative clinical consequences of its use for screening of agents for cancer therapy are pointed out. Also, principles of overcoming the inadequacy of tumor cell clones' expansion inhibition tests and their equivalents are proposed.
Stankov
S V
SV
Pasteur Institute, Novi Sad, Yugoslavia. sstan@EUnet.yu
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor
D000970:Antineoplastic Agents