Nasimaluns A and B: neo-clerodane diterpenoids from barringtonia racemosa.
An ethanolic extract of the roots of Barringtonia racemosa afforded two novel neo-clerodane-type diterpenoids, methyl-15, 16-epoxy-12-oxo-3,13(16),14-neo-clerodatrien-18, 19-olide-17-carboxylate (nasimalun A, 1) and dimethyl-15,16-epoxy-3, 13(16),14-neo-clerodatrien-17,18-dicarboxylate (17-carboxymethylhardwickiic acid methyl ester, nasimalun B, 2) by NMR and MS analyses and by comparison of their spectral data with related compunds. The relative stereochemistry of the asymmetric centers in 1 and 2 was determined by selective 1D NOESY experiments.
Hasan
C M
CM
Phytochemical Research Laboratory, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
Khan
S
S
Jabbar
A
A
Rashid
M A
MA
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis
D004224:Diterpenes; C408005:nasimalun A; C408006:nasimalun B