Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3.
In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.
Wesson
C A
CA
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844-3052, USA.
Deringer
J
J
Liou
L E
LE
Bayles
K W
KW
Bohach
G A
GA
Trumble
W R
WR
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000276:immunology*; D002417:Cattle; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics; D004705:Endocytosis / Q000276:immunology; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology*
D016207:Cytokines; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases