Effect of age and Helicobacter pylori infection on gastric acid secretion.
BACKGROUND
Whether gastric acid secretion decreases with age is still controversial. With the discovery of Helicobacter pylori, the association of this bacterium with gastric acid secretion has also been discussed. The aim of this study was to investigate the relationship between gastric acid secretion, age and H. pylori infection.


METHODS
The presence of H. pylori infection, the grade of fundic atrophic gastritis (FAG), and gastric acid secretion were investigated in 280 subjects without localized lesions in the upper gastrointestinal tract. Helicobacter pylori infection was confirmed by Giemsa and immunohistochemical staining, and FAG of biopsy specimens was graded on a scale of 0-4.


RESULTS
Both basal and maximal acid output decreased with age in H. pylori-positive subjects, while they did not change with age in H. pylori-negative subjects. Gastric acid secretion decreased with the progression of FAG. An age-correlated decrease in gastric acid secretion in H. pylori-positive subjects depended on an increasing prevalence of FAG with age.


CONCLUSIONS
In the population studied, advancing age had no influence on gastric acid secretion in H. pylori-negative subjects. Gastric acid secretion decreases with age in H. pylori-positive subjects because of the increasing prevalence of FAG with age.
Haruma
K
K
First Department of Internal Medicine, Hiroshima University School of Medicine, Kasumi, Japan. kharuma@mcai.med.hiroshima-u.ac.jp
Kamada
T
T
Kawaguchi
H
H
Okamoto
S
S
Yoshihara
M
M
Sumii
K
K
Inoue
M
M
Kishimoto
S
S
Kajiyama
G
G
Miyoshi
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000907:Antibodies, Bacterial / Q000032:analysis; D001706:Biopsy; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000378:metabolism* / Q000382:microbiology; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
D000907:Antibodies, Bacterial; D005755:Gastrins