title: Clinical evaluation of mature teratomas containing malignant elements.
abstract: We investigated the possibility of preoperative diagnosis and clinical features of mature ovarian teratoma containing malignant elements (MOTME). Between 1982 and 1998 in our hospital, MOTME accounted for 2.0% (5 cases) of the total of 251 patients with mature ovarian teratoma (ages, 37-72; mean age, 60.6). Serum CA19-9, CA125, SCC and CEA levels were high. All cases were strongly suspected malignancies, preoperatively diagnosed using serum tumor markers with diagnostic imaging. Two cases of stage I squamous cell carcinoma and one case of borderline malignancy survived, while the other two advanced cases died within 8 months.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka 545-8585, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: F
authors.initials: F
authors.lastname: Itoh
authors.forename: E
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Kanaoka
authors.forename: T
authors.initials: T
authors.lastname: Sumi
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D012189:Retrospective Studies; D015843:Serpins; D016019:Survival Analysis; D013724:Teratoma / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D013997:Time Factors
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D015843:Serpins; C051072:squamous cell carcinoma-related antigen