Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.
Recent advances in our understanding of cytolytic effector mechanisms include the partial characterization of caspase-independent apoptotic pathways triggered by granzymes, a realization of the vital importance of perforin and granzymes in the defence against certain virus infections in vivo and the first description of hereditary immunodeficiency due to disordered perforin expression in humans.
Trapani
J A
JA
The Research Division, The John Connell Laboratory, Peter MacCallum Cancer Institute, St. Andrew's Place, Austin Research Institute, Heidelberg, 3084, Australia. j.trapani@pmci.unimelb.edu. au.
Davis
J
J
Sutton
V R
VR
Smyth
M J
MJ
D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D003594:Cytoplasmic Granules; D003602:Cytotoxicity, Immunologic; D053804:Granzymes; D006801:Humans; D007157:Immunologic Surveillance; D007694:Killer Cells, Natural / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000276:immunology; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D012697:Serine Endopeptidases / Q000378:metabolism; D015843:Serpins / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D015843:Serpins; D054353:Perforin; C509213:GZMB protein, human; D053804:Granzymes; C509214:Gzmb protein, mouse; D012697:Serine Endopeptidases; D020169:Caspases