title: Treatment of skin carcinomas of the face by high-dose-rate brachytherapy and custom-made surface molds.
abstract: OBJECTIVE
  To analyze the results obtained in a prospective group of patients with basal or squamous cell skin carcinomas of the face treated by high-dose-rate (HDR) brachytherapy via custom-made surface molds.
  
  
  METHODS
  A total of 136 patients with basal or squamous cell carcinomas of the face were treated between March 1992 and March 1997 by surface molds and HDR brachytherapy with iridium-192. Nineteen patients were treated with standard Brock applicators and 117 patients with custom-made polymethyl methacrylate applicators, built over a plaster mold obtained of the patient's face. Minimum dose administered to the tumor was 6000 to 6500 cGy in 33 to 36 fractions at 180 cGy/fraction in lesions of up to 4 cm. Lesions greater than 4 cm were boosted up to 7500-8000 cGy after a 3-week pause.
  
  
  RESULTS
  With the custom-made surface molds, the dose distribution was uniform in the surface of the skin and at 5 mm depth in the whole area of the applicator. Differences between the areas of maximum and minimum dose at this depth never reached values higher than 5% of the prescribed dose. At the edges of the custom-made molds dose gradient was sharp, with the detected dose at 5 mm from the applicator being negligible. All the patients were complete responders. There were 3 local recurrences, 1/73 patients treated for primary tumor and 2/63 patients treated for recurrent tumor. Actuarial local control at 5 years for all patients was 98%, for those patients with primary tumors 99%, and for recurrent patients 87%. The treatment tolerance was excellent in all cases. No severe, early, or late, complications were detected.
  
  
  CONCLUSIONS
  Radiotherapy is a highly effective treatment of skin carcinomas of the face. Custom-made molds, to be used in conjunction with HDR brachytherapy equipment, make possible a uniform dose distribution, with a sharp dose gradient in the limits of applicators. Custom-made surface molds are easy and safe to use, and they fit very accurately for daily treatment. Local control is excellent with minimal sequelae or complications. Probably they will become the standard way of treatment of face skin carcinomas in the near future.
authors.affiliation: Department of Radiation Oncology. Fundació IMOR, Institut Mèdic d'Onco Radioteràpia, CORMEN sl. Universitat de Barcelona, Barcelona, Spain. guix@medicina.ub.es
authors.forename: B
authors.initials: B
authors.lastname: Guix
authors.forename: F
authors.initials: F
authors.lastname: Finestres
authors.forename: J
authors.initials: J
authors.lastname: Tello
authors.forename: C
authors.initials: C
authors.lastname: Palma
authors.forename: A
authors.initials: A
authors.lastname: Martinez
authors.forename: J
authors.initials: J
authors.lastname: Guix
authors.forename: R
authors.initials: R
authors.lastname: Guix
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D002280:Basal Cell Carcinoma / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D018572:Disease-Free Survival; D005148:Facial Dermatoses / Q000209:etiology; D005153:Facial Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011855:Radiodermatitis / Q000209:etiology; D011879:Radiotherapy Dosage; D012878:Skin Neoplasms / Q000532:radiotherapy*