title: [The effect of lead on DNA repair in thymocytes of gamma-irradiated mice].
abstract: The effects of Pb on the repair of DNA have been studied in the thymocytes of gamma-irradiated mice exposed to diacetate lead in the drinking water (up to 20 mg/l) for 14-50 days. It is found that lead causes no DNA degradation by itself and renders its genotoxic action indirectly, via inhibiting the repair of single-strand DNA breaks induced by acute gamma-irradiation of mice. Genotoxic effect of lead is reversible that becomes evident when exposed animals are maintained on Pb-free drinking water for 1-2 weeks.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Medvedev
authors.forename: A V
authors.initials: AV
authors.lastname: Chernikov
authors.forename: L N
authors.initials: LN
authors.lastname: Kublik
authors.forename: G I
authors.initials: GI
authors.lastname: Revina
mesh_terms: D000818:Animals; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects*; D005720:Gamma Rays; D007854:Lead / Q000633:toxicity*; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D007854:Lead