title: Effectiveness of a low-fat vegetarian diet in altering serum lipids in healthy premenopausal women.
abstract: Few controlled trials have studied cholesterol-lowering diets in premenopausal women. None has examined the cholesterol-lowering effect of a low-fat vegetarian diet, which, in other population groups, leads to marked reductions in serum cholesterol concentrations and, in combination with other life-style changes, a regression of atherosclerosis. We tested the hypothesis that a low-fat, vegetarian diet significantly reduces serum total and low-density lipoprotein (LDL) cholesterol concentrations in premenopausal women. In a crossover design, 35 women, aged 22 to 48, followed a low-fat vegetarian diet deriving approximately 10% of energy from fat for 2 menstrual cycles. For 2 additional cycles, they followed their customary diet while also taking a "supplement" (placebo) pill. Serum lipid concentrations were assessed at baseline and during each intervention phase. Mean serum LDL, high-density lipoprotein (HDL), and total cholesterol concentrations decreased 16. 9%, 16.5%, and 13.2%, respectively, from baseline to the intervention diet phase (p<0.001), whereas mean serum triacylglycerol concentration increased 18.7% (p<0.01). LDL/HDL ratio remained unchanged. Thus, in healthy premenopausal women, a low-fat vegetarian diet led to rapid and sizable reductions in serum total, LDL, and HDL cholesterol concentrations.
authors.affiliation: Physicians Committee for Responsible Medicine, Washington DC, USA. nbarnard@pcrm.org
authors.forename: N D
authors.initials: ND
authors.lastname: Barnard
authors.forename: A R
authors.initials: AR
authors.lastname: Scialli
authors.forename: P
authors.initials: P
authors.lastname: Bertron
authors.forename: D
authors.initials: D
authors.lastname: Hurlock
authors.forename: K
authors.initials: K
authors.lastname: Edmonds
authors.forename: L
authors.initials: L
authors.lastname: Talev
mesh_terms: D000328:Adult; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018592:Cross-Over Studies; D018752:Diet, Fat-Restricted; D014676:Diet, Vegetarian; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008597:Menstrual Cycle; D008875:Middle Aged; D017697:Premenopause; D015431:Weight Loss
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids