Myoblast therapy for stress urinary incontinence and bladder dysfunction.
The field of tissue engineering and gene therapy has an exciting and promising future. During the past few years we have begun a comprehensive effort to investigate the use of myoblasts to improve and expand the treatment of stress urinary incontinence and bladder dysfunction. Moreover, we can expect the application of myoblast-mediated ex vivo gene transfer in the field of urology. In this paper we discuss the compositions of and methods involving the use of myogenic or muscle-derived cells for tissue engineering and cell-mediated gene therapy.
Yokoyama
T
T
Division of Urologic Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Huard
J
J
Chancellor
M B
MB
D017690:Cell Transplantation; D006801:Humans; D009130:Muscle, Smooth / Q000166:cytology; D013997:Time Factors; D001745:Urinary Bladder Diseases / Q000628:therapy*; D014550:Urinary Incontinence, Stress / Q000628:therapy*