title: Cerebrospinal fluid pleocytosis in acute lymphoblastic leukemia without central nervous system relapse: a report of three cases.
abstract: Three patients with acute lymphoblastic leukemia (ALL) developed mononuclear cells in the cerebrospinal fluid (CSF) after a flu-like history during maintenance treatment. None of the patients showed evidence of central nervous system (CNS) involvement by either clinical or laboratory follow-up. Although the presence of > 5 mononuclear cells/microl in the CSF is important, it may not necessarily indicate CNS disease. Clinical findings, history and cell morphology must be evaluated before deciding on further treatment.
authors.affiliation: Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
authors.forename: A F
authors.initials: AF
authors.lastname: Oner
authors.forename: S
authors.initials: S
authors.lastname: Yetgin
authors.forename: D
authors.initials: D
authors.lastname: Uçkan
mesh_terms: D002493:Central Nervous System Diseases / Q000209:etiology; D002555:Cerebrospinal Fluid / Q000276:immunology; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007963:Leukocytes, Mononuclear; D007964:Leukocytosis / Q000209:etiology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000150:complications