Kyanomycin, a complex of unusual anthracycline-phospholipid hybrids from Nonomuria species.
A blue secondary metabolite complex, named kyanomycin (2), in addition to epsilon-rhodomycinone (1), was detected in the mycelium extract of Nonomuria sp. NN 22303 by HPLC-diode array and HPLC-electrospray mass spectrometry screening. The chemical structures of the novel compounds were determined to be unusual anthracycline-phosphatidylethanolamine hybrids by spectroscopic and chemical degradation experiments.
Pfefferle
C M
CM
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
Breinholt
J
J
Olsen
C E
CE
Kroppenstedt
R M
RM
Wellington
E M
EM
Gürtler
H
H
Fiedler
H P
HP
D000192:Actinomycetales / Q000737:chemistry*; D018943:Anthracyclines / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D008826:Microbial Sensitivity Tests; D010743:Phospholipids / Q000737:chemistry*; D013057:Spectrum Analysis
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D010743:Phospholipids; C408063:kyanomycin