Comparative mapping of the human homologue of the rat diabetes susceptibility gene lyp to a 1.3-Mb segment on HSA7.
The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved segment: CASP2 and PRSS1 are localized to 7q35, while NPY is localized to 7p15.1. This raises the question whether the human homologue of Lyp is linked to CASP2/PRSS1 or to NPY. We present a comparative map of the Lyp region in rat and human, assigning the gene to a 1.3-Mb segment between RNY3 and ABP1 at 7q35.
Hornum
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Hagedorn Research Institute, Niels Steensens Vej 6, Gentofte, DK-2820, Denmark.
Markholst
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D006631:Amine Oxidase (Copper-Containing); D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D002460:Cell Line; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D004247:DNA / Q000737:chemistry / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008231:Lymphopenia / Q000235:genetics*; D008969:Molecular Sequence Data; D018807:Polymorphism, Single-Stranded Conformational; D020733:RNA, Small Cytoplasmic / Q000235:genetics; D051381:Rats; D011913:Rats, Inbred BB; D011914:Rats, Inbred BN; D017422:Sequence Analysis, DNA
D002352:Carrier Proteins; D020733:RNA, Small Cytoplasmic; D004247:DNA; D006631:Amine Oxidase (Copper-Containing); C065976:AOC1 protein, human