[The role of arachidonic acid derivatives in generating membrane potential oscillations of the rat aorta endothelium].
Involvement of metabolites of arachidonic acid in electrical responses of rat aortic endothelium evoked by the agonist of aa1-adrenoreceptors, phenylephrine has been investigated. Our experiments suggest that phenylephrine evokes synthesis of thromboxane A2 in the rat aorta that is involved in the phenylephrine-evoked oscillations probably by increasing excitatory effect of the vasoconstrictor on vascular smooth muscle by the mechanism of positive feedback.
Marchenko
S M
SM
A. A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000502:physiology; D001095:Arachidonic Acids / Q000502:physiology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats
D000316:Adrenergic alpha-Agonists; D001095:Arachidonic Acids; D010656:Phenylephrine