The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
t(9;14)(p13;q32) is a rare but recurring translocation found in a subset of B-cell non-Hodgkin's lymphoma (B-NHL). These lymphomas share clinical features with chronic lymphocytic leukemia and are further characterized by plasmacytoid differentiation of lymphoma cells. Molecular cloning of t(9;14)(p13;q32) revealed juxtaposition of the PAX5 to the immunoglobulin heavy chain gene (IGH), although breakpoints on both genes were variable. The PAX5 gene encodes the BSAP (B-cell-specific activator protein) transcription factor, which is expressed throughout the process of B-cell development except in terminally differentiated plasma cells. t(9;14)(p13;q32) consistently leaves the PAX5 coding region intact, most likely resulting in deregulated expression of the gene product due to the proximity of IGH. The majority cases of B-cell tumors expressed considerable levels of PAX5/BSAP irrespective of whether they exhibited t(9;14)(p13;q32), suggesting that quantitative differences in expression level alone may not account for the development of this particular subtype of B-NHL.
Ohno
H
H
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan. hohno@kuhp.kyoto-u.ac.jp
Ueda
C
C
Akasaka
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T
D000595:Amino Acid Sequence; D001483:Base Sequence; D002454:Cell Differentiation; D002883:Chromosomes, Human, Pair 14; D002899:Chromosomes, Human, Pair 9; D004268:DNA-Binding Proteins; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology; D008969:Molecular Sequence Data; D051757:PAX5 Transcription Factor; D011506:Proteins / Q000235:genetics; D014157:Transcription Factors; D014178:Translocation, Genetic
D004268:DNA-Binding Proteins; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human; D011506:Proteins; D014157:Transcription Factors