title: Premature closure of the foramen ovale associated with aortic stenosis, left ventricular dilation with thrombus, and early mortality.
abstract: Premature foramen ovale (FO) closure has been postulated as a cause of hypoplastic left heart syndrome. We suggest that premature FO closure is also associated with left ventricular (LV) dilation and LV thrombus formation, and that FO closure in patients with aortic stenosis and LV dilation is a secondary event that occurs later in gestation than that seen with the hypoplastic left heart.
authors.affiliation: Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Dallas, TX 77030, USA.
authors.forename: T T
authors.initials: TT
authors.lastname: Nowlen
authors.forename: N A
authors.initials: NA
authors.lastname: Ayres
authors.forename: D L
authors.initials: DL
authors.lastname: Kearney
authors.forename: M R
authors.initials: MR
authors.lastname: Nihill
authors.forename: R G
authors.initials: RG
authors.lastname: Grifka
mesh_terms: D001024:Aortic Valve Stenosis / Q000503:physiopathology*; D003328:Coronary Thrombosis / Q000503:physiopathology*; D004108:Dilatation, Pathologic; D005313:Fetal Death; D006346:Heart Septum / Q000503:physiopathology*; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male