title: Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity.
abstract: We report the discovery of Eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol, isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist, and furthermore inhibits human platelet aggregation in vitro.
authors.affiliation: Bioprocessing Unit, Glaxo-Wellcome Medicines Research Centre, Stevenage, Herts, UK. ps29705@glaxowellcome.co.uk
authors.forename: P
authors.initials: P
authors.lastname: Stead
authors.forename: S
authors.initials: S
authors.lastname: Hiscox
authors.forename: P S
authors.initials: PS
authors.lastname: Robinson
authors.forename: N B
authors.initials: NB
authors.lastname: Pike
authors.forename: P J
authors.initials: PJ
authors.lastname: Sidebottom
authors.forename: A D
authors.initials: AD
authors.lastname: Roberts
authors.forename: N L
authors.initials: NL
authors.lastname: Taylor
authors.forename: A E
authors.initials: AE
authors.lastname: Wright
authors.forename: S A
authors.initials: SA
authors.lastname: Pomponi
authors.forename: D
authors.initials: D
authors.lastname: Langley
mesh_terms: D000818:Animals; D006367:HeLa Cells; D006801:Humans; D007810:Lanosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D018179:Receptors, Thrombin / Q000037:antagonists & inhibitors*; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D018179:Receptors, Thrombin; D012503:Saponins; C412031:eryloside F; C093430:penasterol; D007810:Lanosterol