Therapeutic cloning: concepts and practicalities.
The concept of using embryonic stem (ES) cells as a source of multiple cell types for use in tissue repair has existed for approximately 20 years. Recent breakthroughs in somatic nuclear transfer and human ES cell derivation have produced a flurry of new activity in this area, with the recognition that ES cell lines that are customized and genetically identical to those of the patient are a distinct possibility. This article examines the background of and prospects for these exciting new developments.
Colman
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PPL Therapeutics, Roslin, Edinburgh, UK. acolman@ppl-therapeutics.com
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D000818:Animals; D002454:Cell Differentiation; D017690:Cell Transplantation / Q000379:methods*; D003001:Cloning, Molecular; D004622:Embryo, Mammalian / Q000166:cytology; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D009865:Oocytes / Q000502:physiology; D013234:Stem Cells