title: Punctate midline myelotomy for the relief of visceral cancer pain.
abstract: OBJECTIVE
  This study offers clinical support for the concept that neurosurgical interruption of a midline posterior column pathway by performing a punctate midline myelotomy (PMM) provides significant pain relief without causing adverse neurological sequelae in cancer patients with visceral pain refractory to other therapies.
  
  
  METHODS
  A PMM of the posterior columns was performed in six cancer patients in whom visceral pain had been refractory to other therapies. The cause of the visceral pain was related to residual, progressive, or recurrent local cancer or postirradiation effects. Clinical efficacy of the procedure was examined by comparing patient pain ratings and narcotic usage pre- and post-PMM. Follow-up periods ranged from 3 to 31 months. Examination of the results indicates a significant reduction in pain ratings as well as a significant reduction in daily narcotic use. No adverse neurological effects were observed. One spinal cord has been recovered for postmortem examination.
  
  
  CONCLUSIONS
  These findings provide corroborating clinical evidence for the existence of a newly recognized midline posterior column pathway that mediates the perception of visceral pelvic and abdominal pain. Preliminary data indicate that significant pain relief can be obtained following PMM with minimal neurological morbidity and suggest that the procedure may provide an alternative treatment modality for cancer-related pain in patients in whom adequate pain control with narcotics cannot be achieved or narcotic side effects cannot be tolerated.
authors.affiliation: Department of Neurology, University of Texas Medical Branch, Galveston 77555-0517, USA. svansitt@utmb.edu
authors.forename: H J
authors.initials: HJ
authors.lastname: Nauta
authors.forename: V M
authors.initials: VM
authors.lastname: Soukup
authors.forename: R H
authors.initials: RH
authors.lastname: Fabian
authors.forename: J T
authors.initials: JT
authors.lastname: Lin
authors.forename: J J
authors.initials: JJ
authors.lastname: Grady
authors.forename: C G
authors.initials: CG
authors.lastname: Williams
authors.forename: G A
authors.initials: GA
authors.lastname: Campbell
authors.forename: K N
authors.initials: KN
authors.lastname: Westlund
authors.forename: W D
authors.initials: WD
authors.lastname: Willis
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology / Q000503:physiopathology*; D015746:Abdominal Pain / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010148:Intractable Pain / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010166:Palliative Care; D013116:Spinal Cord / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome