title: Telephone-administered cognitive-behavioral therapy for the treatment of depressive symptoms in multiple sclerosis.
abstract: This study examined the efficacy of an 8-week telephone-administered cognitive-behavioral therapy (CBT) for the treatment of depressive symptomatology in multiple sclerosis (MS) patients. The treatment, Coping with MS (CMS), included a patient workbook designed to structure the treatment, provide visual aids, and help with homework assignments. Thirty-two patients with MS, who scored at least 15 on the Profile of Mood States Depression-Dejection scale, were randomly assigned to either the telephone CMS or to a usual-care control (UCC) condition. Depressive symptomatology decreased significantly in the CMS condition compared with the UCC condition. Furthermore, adherence to interferon beta-1a, a disease-modifying medication for the treatment of MS, was significantly better at the 4-month follow-up among patients who received CMS as compared with those in the UCC condition.
authors.affiliation: Department of Neurology, University of California, San Francisco (UCSF) 94115-1642, USA. dmohr@itsa.ucsf.edu
authors.forename: D C
authors.initials: DC
authors.lastname: Mohr
authors.forename: W
authors.initials: W
authors.lastname: Likosky
authors.forename: A
authors.initials: A
authors.lastname: Bertagnolli
authors.forename: D E
authors.initials: DE
authors.lastname: Goodkin
authors.forename: J
authors.initials: J
authors.lastname: Van Der Wende
authors.forename: P
authors.initials: P
authors.lastname: Dwyer
authors.forename: L P
authors.initials: LP
authors.lastname: Dick
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000523:psychology*; D010349:Patient Compliance / Q000523:psychology; D010555:Personality Inventory; D012803:Sick Role; D013689:Telephone