Yomogin inhibits the degranulation of mast cells and the production of the nitric oxide in activated RAW 264.7 cells.
Yomogin (1), an eudesmane sesquiterpene isolated from Artemisia princeps, was tested for the effects on the degranulation process of cultured mast cells and on the nitric oxide production in LPS-activated murine macrophages. It demonstrated a significant inhibition on the release of beta-hexosaminidase from the cultured RBL-2H3 cells in a dose-dependent manner (IC50 value, 50 microM) and also exhibited a potent inhibition on the nitric oxide production from the activated RAW264.7 cells (IC50 value, 3 microM).
Ryu
S Y
SY
Oak
M H
MH
Kim
K M
KM
D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane
D004791:Enzyme Inhibitors; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C117320:yomogin; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase