Ultra-high resolution DNA structures.
This paper describes the progress in our efforts at producing ultra-high resolution (< 0.8 A) DNA structures using advanced cryo-crystallography and synchrotron. Our work is aimed at providing reliable geometric (bond length and bond angle), electronic and motional information of DNA molecules in different conformational contexts. These highly-reliable, new structures will be the basis for constructing better DNA force-field parameters, which will benefit the structural refinement of DNA, protein-DNA complexes, and ligand-DNA complexes.
Wang
A H
AH
Department of Cell and Structural Biology, University of Illinois, at Urbana-Champaign, 61801, USA.
Robinson
H
H
Gao
Y G
YG
D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D001483:Base Sequence; D018360:Crystallography, X-Ray / Q000379:methods; D004247:DNA / Q000737:chemistry*; D003630:Daunorubicin / Q000737:chemistry*; D008024:Ligands; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D012680:Sensitivity and Specificity; D017356:Synchrotrons
D000903:Antibiotics, Antineoplastic; D008024:Ligands; D009838:Oligodeoxyribonucleotides; D004247:DNA; D003630:Daunorubicin