[The phenotype characteristics of cord blood lymphocytes in premature neonates].
It has been observed high risk of infections in neonates as a result from lymphocytes immaturity. It is connected to phenotype differences of lymphocytes between neonates and adults. This high susceptibility to infections is especially high in premature neonates. With the use of flow cytometry we have evaluated the phenotype of cord blood lymphocytes in premature neonates. In comparison to results of healthy newborns we have observed significant decrease in CD7+, CD3+, CD4+, CD25+, CD57+ lymphocytes an increase in total number of CD8+ cells as well as alteration in CD4/CD8 ratio. Our results suggest deeply damage of cellular immunity in preterm infants.
Pietruczuk
M
M
Zakładu Diagnostyki Hematologicznej, Instytutu Diagnostyki Laboratoryjnej, Akademii Medycznej w Białymstoku.
Dabrowska
M
M
Jaworski
S
S
Wasiluk
A
A
D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007231:Infant, Newborn; D007234:Infant, Premature; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D010641:Phenotype
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D006684:HLA-DR Antigens