title: Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa.
abstract: Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 microM.
authors.affiliation: Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Spain.
authors.forename: H
authors.initials: H
authors.lastname: Chávez
authors.forename: G
authors.initials: G
authors.lastname: Rodríguez
authors.forename: A
authors.initials: A
authors.lastname: Estévez-Braun
authors.forename: A G
authors.initials: AG
authors.lastname: Ravelo
authors.forename: R
authors.initials: R
authors.lastname: Estévez-Reyes
authors.forename: A G
authors.initials: AG
authors.lastname: González
authors.forename: J L
authors.initials: JL
authors.lastname: Fdez-Puente
authors.forename: D
authors.initials: D
authors.lastname: García-Grávalos
mesh_terms: D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D014315:Triterpenes