title: Synthesis and properties of oligonucleotides containing 2'-pyrenylalkyluridine.
abstract: The synthesis, binding and fluorescence properties of oligonucleotides containing the uridine modified at the 2'-position by a pyrene group using different length of linker arm have been described. It is demonstrated that the oligonucleotides possessing a C3-amide group at the 2'-position display an enhanced signal of the pyrene monomer fluorescence upon binding to DNA segments.
authors.affiliation: Department of Applied Chemistry, Himeji Institute of Technology, Hyogo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamana
authors.forename: K
authors.initials: K
authors.lastname: Asazuma
authors.forename: H
authors.initials: H
authors.lastname: Nakano
mesh_terms: D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014529:Uridine / Q000031:analogs & derivatives*
chemical_list: D009838:Oligodeoxyribonucleotides; D004247:DNA; D014529:Uridine