[An acute toxicity study of bromantane].
The toxicity of bromantan was evaluated by conventional acute tests (according to Belen'kiĭ) and by the behavioral activity data (according to Irvin). A method of integral graphical representation of the behavioral activity data is suggested, according to which the results are plotted as a "dose trajectory." Using the dose trajectory constructed for bromantan, the levels of therapeutic, toxic, and lethal doses were calculated. It was established that catecholaminergic effects account for the mechanism of therapeutic action of bromantan, while cholinergic effects determine the drug action in toxic doses.
Bugaeva
L I
LI
Institute of Pharmacology, Volgograd State Medical Academy, Ministry of Public Health of the Russian Federation, Russia.
Verovskiĭ
V E
VE
Iezhitsa
I N
IN
Spasov
A A
AA
D000276:Adjuvants, Immunologic / Q000633:toxicity*; D000547:Amantadine / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007928:Lethal Dose 50; D011619:Psychotropic Drugs / Q000633:toxicity*; D051381:Rats
D000276:Adjuvants, Immunologic; D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane