title: Proinflammatory and regulatory cytokine levels in AIDS cachexia.
abstract: The serum concentrations of inflammatory (Interleukin-1 beta, Tumor necrosis alpha, Interleukin-6) and regulatory cytokines (Interleukin twelve) have been studied in ten AIDS cachectic patients and compared to a control group. A cytokine imbalance, and peculiarly a significant increase in proinflammatory cytokines (Interleukin-1, Interleukin-6, Tumor necrosis Factor alpha) and a decrease in regulatory cytokines such as Interleukin-12 were found. A significant correlation resulted between weight loss and Interleukin-1 beta and 6. A negative correlation between Interleukin-1 and 12 was noted, indicating that this last cytokine has an important regulatory role also in advanced state of the disease.
authors.affiliation: Hyperthermia and Oncology Session, Centri Clinici Chirurgici Padre Pio, Va, Italy. barongf@infoplus.it
authors.forename: G
authors.initials: G
authors.lastname: Baronzio
authors.forename: A
authors.initials: A
authors.lastname: Zambelli
authors.forename: D
authors.initials: D
authors.lastname: Comi
authors.forename: A
authors.initials: A
authors.lastname: Barlocco
authors.forename: A
authors.initials: A
authors.lastname: Baronzio
authors.forename: P
authors.initials: P
authors.lastname: Marchesi
authors.forename: A
authors.initials: A
authors.lastname: Gramaglia
authors.forename: E
authors.initials: E
authors.lastname: Castiglioni
authors.forename: A
authors.initials: A
authors.lastname: Mafezzoni
authors.forename: E
authors.initials: E
authors.lastname: Beviglia
authors.forename: F
authors.initials: F
authors.lastname: Crespi
authors.forename: A I
authors.initials: AI
authors.lastname: Cargnel
authors.forename: G
authors.initials: G
authors.lastname: Pravettoni
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D019247:HIV Wasting Syndrome / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015431:Weight Loss
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12