title: Efficacy of nerve root versus interspinous injections of glucocorticoids in the treatment of disk-related sciatica. A pilot, prospective, randomized, double-blind study.
abstract: OBJECTIVE
  Pilot study comparing the short-term efficacy on pain and functional impairment of nerve root sheath versus interspinous glucocorticoid injections in patients admitted to a French rheumatology department for disk-related sciatica or femoral neuralgia.
  
  
  METHODS
  Thirty patients with refractory nerve root pain (sciatica, n = 29; femoral neuralgia, n = 1) for a mean of four months were randomized to nerve root injection (n = 17) or interspinous injection (n = 13) of the same mixture of 0.10 g of lidocaine hydrochloride and 3.75 mg of cortivazol. Both injection methods were performed under analgesia and benzodiazepine sedation to maintain double blinding. Each patient was evaluated daily during the first seven days of bed rest in the hospital, then after discharge on postinjection day 28.
  
  
  RESULTS
  Prompt pain relief was obtained in both groups. On day 1, the mean pain scale score (0-100) fell from 70 +/- 3.9 to 26 +/- 5.6 in the nerve root group and from 63 +/- 4 to 23 +/- 4.7 in the interspinous group. These results were sustained on D7 and D28.
  
  
  CONCLUSIONS
  The unusually high level of efficacy of glucocorticoid injection in our study may be ascribable in part to strong placebo and Hawthorne effects and in part to the intrinsic effects of the injections. Whether nerve root injection is superior over interspinous injection remains unproven.
authors.affiliation: Rheumatology Department, Nantes Teaching Hospital, Hôtel-Dieu, France.
authors.forename: I
authors.initials: I
authors.lastname: Kolsi
authors.forename: J
authors.initials: J
authors.lastname: Delecrin
authors.forename: J M
authors.initials: JM
authors.lastname: Berthelot
authors.forename: L
authors.initials: L
authors.lastname: Thomas
authors.forename: A
authors.initials: A
authors.lastname: Prost
authors.forename: Y
authors.initials: Y
authors.lastname: Maugars
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011281:Pregnatrienes / Q000008:administration & dosage*; D011446:Prospective Studies; D012585:Sciatica / Q000188:drug therapy*; D013126:Spinal Nerve Roots
chemical_list: D005938:Glucocorticoids; D011281:Pregnatrienes; C005924:cortivazol