Insulin sensitivity in normotensive offspring of hypertensive parents.
OBJECTIVE
To investigate the insulin sensitivity in normotensive offspring of hypertensive parents.


METHODS
Fifteen young normotensive offspring of hypertensive parents were paired with 15 controls matched for age, sex and body mass index.


METHODS
The insulin sensitivity was investigated by 75 g oral glucose tolerance test (OGTT) and modified insulin suppression test. A high-fat mixed meal was administered to observe the changes of TG levels.


RESULTS
The plasma glucose and serum insulin responses to oral glucose challenge were comparable between both groups. High-fat mixed meal made no difference in the plasma glucose, serum triglyceride or insulin between the 2 groups. With the modified insulin suppression test, the steady-state plasma glucose levels (SSPG) were higher in the offspring of parents with essential hypertension (138+/-43 mg/dl) than in the control group (95+/-26 mg/dl). The diastolic blood pressure and heart rate of the offspring of hypertensive parents are also higher than the control group.


CONCLUSIONS
Insulin resistance exists in young normotensive offspring of hypertensive parents, and the impairment of insulin-mediated glucose uptake in these subjects develop before any alteration of fasting and postprandial triglyceride.
Chen
H S
HS
Department of Medicine, Veterans General Hospital-Taipei, Taiwan, ROC.
Hwu
C M
CM
Kwok
C F
CF
Shih
K C
KC
Hsiao
L C
LC
Lee
S H
SH
Lin
Y T
YT
Lin
S H
SH
Ho
L T
LT
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001823:Body Composition; D001824:Body Constitution; D003971:Diastole; D004041:Dietary Fats; D005260:Female; D005951:Glucose Tolerance Test; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D009679:Nuclear Family; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D014280:Triglycerides