title: [Effects of automobile lead on the general growth and sexual activity of the rat].
abstract: To identify the active element of automotive exhaust gas responsible for masculine infertility, previously proved by our laboratory, we undertook these experiments. Four hundred young male and female rats were exposed during two months (30 min/d) to three types of automotive exhaust gases. The first type emanated from an engine running on gasoline with lead, the second from an unleaded gasoline engine, the third from a diesel engine. These three engines had the same power (5 horsepower vehicles < 3.5 tons). For the first type of emissions, some lead deposits were found in the lungs by histologic techniques. This gas also induced in male rats the atrophy of the testicle, seminal vesicle and epididym, certain pathological changes in spermatogenesis shown by the histologic study, and a decrease of the serum's testosterone level. In female rats, the relative weights of the ovary and uterus, as well as the percentage of the arrival of oestrus, were not affected by the gaseous treatment. Both the second and third types of gases seemed less active on the masculine sex as far as these parameters are concerned. Our study suggests that, for light vehicles, leaded gasoline pollutes more than unleaded gasoline or diesel fuels, and that the lead present only in the first type would be the active element responsible for the masculine infertility and body weight gain reduction in rats.
authors.affiliation: Laboratoire d'écophysiologie animale, faculté des sciences de Sfax, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: el Feki
authors.forename: F
authors.initials: F
authors.lastname: Ghorbel
authors.forename: M
authors.initials: M
authors.lastname: Smaoui
authors.forename: F
authors.initials: F
authors.lastname: Makni-Ayadi
authors.forename: A
authors.initials: A
authors.lastname: Kammoun
mesh_terms: D000818:Animals; D001284:Atrophy; D004822:Epididymis / Q000473:pathology; D005260:Female; D007248:Infertility, Male / Q000139:chemically induced*; D007854:Lead / Q000032:analysis / Q000494:pharmacology / Q000633:toxicity*; D008168:Lung / Q000737:chemistry; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar; D012669:Seminal Vesicles / Q000473:pathology; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood; D014599:Uterus / Q000254:growth & development; D001335:Vehicle Emissions / Q000032:analysis*
chemical_list: D001335:Vehicle Emissions; D007854:Lead; D013739:Testosterone