An efficient method for the synthesis of sulbactam pivoxil.
Sulbactam pivoxil, a prodrug of the beta-lactamase inhibitor sulbactam, was prepared in high yield by reacting the sodium salt of sulbactam with chloromethyl pivalate in a polar solvent, then diluting the reaction mixture with water and isolating the product by filtration. Dimethyl sulfoxide was found to be the solvent of choice among several aprotic organic solvents.
Changov
L S
LS
University of Chemical Technology and Metallurgy, Sofia, Bulgaria. lschangov@hotmail.com
Vassileva
B K
BK
Confino
M N
MN
Agapova
N N
NN
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D013407:Sulbactam / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D065093:beta-Lactamase Inhibitors
D004791:Enzyme Inhibitors; D011355:Prodrugs; D065093:beta-Lactamase Inhibitors; C035975:sulbactam pivoxyl; D013407:Sulbactam