title: [Buschke and Loewenstein tumors (giant condyloma acuminata). Immunologic features].
abstract: The Buschke-Loewenstein tumor, also called giant condyloma acuminatum, is generally observed in male subjects, usually on the penis and rarely occurs in women. A case of Buschke-Loewenstein tumor located on the vulva is reported. It is a cauliflower-like tumor which behaves clinically in a malignant fashion, although it shows no histomorphological criteria of malignancy. Histologically it is a benign papillomatous growth characterized predominantly by epithelial hyperplasia, hyperacanthosis and hyperkeratosis. The assessment of humoral and cellular immunity demonstrated an unusual circulating increase of CD4+ lymphocytes suggesting their major role in the very slow progression of the disease. Surgery remains the treatment of choice for this tumor.
authors.forename: V
authors.initials: V
authors.lastname: Bognoni
authors.forename: P
authors.initials: P
authors.lastname: Iacopino
authors.forename: A
authors.initials: A
authors.lastname: Quartuccio
authors.forename: G
authors.initials: G
authors.lastname: Santoro
authors.forename: A
authors.initials: A
authors.lastname: Quartuccio
mesh_terms: D003218:Condylomata Acuminata / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D014845:Vulvar Diseases / Q000276:immunology* / Q000473:pathology