title: [The effects of the intraventricular administration of captopril on water and ion metabolism in the rst].
abstract: The effects of the conversion enzyme on the hydroelectrolytic balance in adult rats, maintained in standard lab conditions have been followed. The administration protocol for the conversion inhibitor (captopril) produced a blocking of the transformation of angiotensin I in angiotensin II only at the level of the cerebral structures, during the whole period of the treatment (40 micrograms/kg x 3/24 hours). Following the intracerebroventricular (ICV) administration of captopril, the fluid ingestion decreased diuresis and urinary elimination of Na+ and Ca++ increased. The results plead for the existence of a cerebral renin-angiotensin system, which intervenes in the control of the hydroelectrolyte metabolism.
authors.affiliation: Disciplina de Fiziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: S M
authors.initials: SM
authors.lastname: Slătineanu
authors.forename: I
authors.initials: I
authors.lastname: Haulică
authors.forename: A
authors.initials: A
authors.lastname: Costuleanu
authors.forename: I
authors.initials: I
authors.lastname: Mândreci
authors.forename: G
authors.initials: G
authors.lastname: Petrescu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000008:administration & dosage* / Q000494:pharmacology; D002395:Catecholamines / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014867:Water / Q000378:metabolism*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D002395:Catecholamines; D004573:Electrolytes; D014867:Water; D002216:Captopril