title: Local control in differentiated thyroid carcinoma with extrathyroidal invasion.
abstract: BACKGROUND
  The clinical significance of microscopically locoresional-residual differentiated thyroid carcinoma is still an unsolved problem.
  
  
  METHODS
  Patients who underwent resectional management for advanced differentiated thyroid carcinoma were divided into complete (n = 58), microscopic (n = 37), macroscopic (n = 14), and distant (n = 22) groups.
  
  
  RESULTS
  Postoperative recurrence was similar in the complete (28%) and microscopic (22%) groups and was significantly lower than that of the macroscopic (57%) and distant (67%) groups. Age, gender, lymph node metastasis, and the residual status (complete and microscopic versus macroscopic and distant) were independent risk factors for recurrence. Postoperative survival of the complete and microscopic groups groups was better than that of the macroscopic and distant groups. Age and the residual status were independent prognostic factors for overall and cause-specific survival.
  
  
  CONCLUSIONS
  Postoperative recurrence and survival of patients with microscopic residual cancer were similar to those of patients with complete resection, and macroscopic residual cancer either in locoregional or distant loci was an ominous prognostic sign.
authors.affiliation: Department of Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nishida
authors.forename: K
authors.initials: K
authors.lastname: Nakao
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000145:classification / Q000473:pathology / Q000556:secondary / Q000601:surgery; D000367:Age Factors; D000704:Analysis of Variance; D002277:Carcinoma / Q000145:classification / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000145:classification / Q000473:pathology / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000517:prevention & control*; D018365:Neoplasm, Residual; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000145:classification / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods