title: Control of initiation of sporulation by replication initiation genes in Bacillus subtilis.
abstract: Initiation of spore formation in Bacillus subtilis appears to depend on initiation of DNA replication. This regulation was first identified using a temperature-sensitive mutation in dnaB. We found that mutations in the replication initiation genes dnaA and dnaD also inhibit sporulation, indicating that inhibition of sporulation is triggered by general defects in the function of replication initiation proteins.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: K P
authors.initials: KP
authors.lastname: Lemon
authors.forename: I
authors.initials: I
authors.lastname: Kurtser
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: A D
authors.initials: AD
authors.lastname: Grossman
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics* / Q000502:physiology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial; D013171:Spores, Bacterial / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria; C092895:DnaD protein, Bacillus subtilis