title: Postantibiotic effect of trovafloxacin against Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis in cerebrospinal fluid and broth culture media.
abstract: Trovafloxacin displays exceptional antimicrobial potency against pathogens associated with community-acquired meningitis. The postantibiotic effect (PAE) of trovafloxacin was assessed against two clinical strains each of Streptococcus pneumoniae, Haemophilus influenzae Type B, and Neisseria meningitidis Group B. Testing was performed simultaneously in broth culture media (broth) and pooled CSF at concentrations equivalent to 0.5X and 4X MIC. Mean PAEs in broth at 0.5X and 4X MIC ranged between 0.07 to 1.10 and 0.57 to 5. 83 h and between 0.07 to 1.67 and 0.47 to 6.00 h in CSF for all organisms. Overall, the incorporation of CSF did not augment or diminish the duration of the trovafloxacin-induced PAE. These data, together with its pharmacokinetic profile in CSF and antimicrobial potency against these isolates, make trovafloxacin an agent of interest for the treatment of meningitis.
authors.affiliation: Department of Pharmacy ResearchHartford Hospital, Hartford, CT, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Tessier
authors.forename: C H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: D P
authors.initials: DP
authors.lastname: Nicolau
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002555:Cerebrospinal Fluid; D003470:Culture Media; D024841:Fluoroquinolones; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology*; D009345:Neisseria meningitidis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D000890:Anti-Infective Agents; D003470:Culture Media; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin