The influence of some prostaglandin analogous on the female rat ovary and uterine tube epithelium.
The synthetic analogous of the prostaglandins are utilized in the obstetrical and gynecological therapy for multiple purposes. 4 lots with 12 nonpregnant female rats were use: the Ist received 25 g/kg/day isopropyl ester PGF2; the IInd lot received 50 g/kg/day isopropyl ester PGF2; the IIIrd lot received 50 g/kg/day optic active cloprostenol; the IVth lot was the witness lot. The medication was intraperitoneally (i.p.) administrated in a unique daily dose. Prostaglandin F2 analogous at small doses (25 micrograms/kg/day) induce vasodilating effects on the ovary blood vessels and functional luteolysis rather than structural luteolysis. Both of the prostaglandins analogous at doses of 50 micrograms/kg/day present obvious vasodilating and luteolytic effects, although the intensity of the phenomenon is not the same, cloprostenol is more active, inducing a more obvious vasodilatation and luteolysis.
Indrei
A
A
Faculty of Stomatologic Medicine, University of Medicine and Pharmacy Gr. T. Popa, Iaşi.
Nechifor
M
M
Mihalache
G
G
Grigore
M
M
Cocu
F
F
Indrei
L L
LL
D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D010053:Ovary / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D018709:Statistics, Nonparametric; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
D003008:Cloprostenol; C041158:prostaglandin F2 isopropyl ester; D015237:Dinoprost