title: [Intravesical drug therapy in women with severe urge incontinence. Clinical experiences from a department of gynecology].
abstract: Conventional oral pharmacotherapy for urge incontinence remains problematic because of limited efficacy and systemic side effects. In this study 27 patients with severe urge incontinence were treated with intravesical drugs (emepron 200 mg or oxybutynin 5 mg) twice a day. They had previously on average undergone 3.3 other treatment options without satisfactory effect. The average age was 62 years, and their incontinence had on average lasted for 15 years. Seven percent were cured and 41% were improved. Fifty-two percent had no satisfactory effect of the treatment. The number of side effects was low, and none left the study for this reason. Intravesical anticholinergic pharmacotherapy can be a treatment option in women with severe urge incontinence.
authors.affiliation: Gynaekologisk/obstetrisk afdeling, Amtssygehuset i Glostrup.
authors.forename: J K
authors.initials: JK
authors.lastname: Johansen
authors.forename: G
authors.initials: G
authors.lastname: Lose
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D000368:Aged; D018680:Cholinergic Antagonists / Q000008:administration & dosage*; D004629:Emepronium / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008333:Mandelic Acids / Q000008:administration & dosage*; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome; D014546:Urinary Catheterization; D014549:Urinary Incontinence / Q000188:drug therapy*
chemical_list: D018680:Cholinergic Antagonists; D008333:Mandelic Acids; D010276:Parasympatholytics; D004629:Emepronium; C005419:oxybutynin