title: Wet spun chitosan-collagen fibers, their chemical N-modifications, and blood compatibility.
abstract: Based on an in vitro test for an improvement of the blood compatibility of chitin by blending with tropocollagen, we prepared a novel biocompatible blended fiber and its chemically N-modified fibers. Each (1 g/30 ml) of a clear mixed solution of chitosan with tropocollagen or collagen and a clear solution of chitosan itself in aqueous 2% acetic acid-methanol (2:1, v/v) was spun through a viscose-type spinneret into an aqueous 5% ammonia solution containing 40-43% ammonium sulfate at room temperature to afford a white fiber of chitosan-tropocollagen blends (1.08-1.65 g/denier for the tenacity and 10.9-43.2% for the elongation). The tropocollagen content up to 50% by weight) in the blended fiber affected little their tenacity and elongation values. The blended fiber was chemically N-modified at the fiber state by treatment with a series of carboxylic anhydrides and aldehydes to afford the corresponding N-modified fiber (0.86-1.31 g/denier for the tenacity and 8.0-12.1% for the elongation). A transparent blended hydrogel of N-acetylchitosan (chitin) with tropocollagen was produced from the above mixed solution by treatment with acetic anhydride, and its membrane and sponge sheet were also prepared from the hydrogel.
authors.affiliation: Chitin/Chitosan R & D, Tottori, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Hirano
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Miyata
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001777:Blood Coagulation; D001790:Blood Physiological Phenomena; D003386:Brachyura; D002686:Chitin / Q000031:analogs & derivatives*; D048271:Chitosan; D003094:Collagen; D004285:Dogs; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D017550:Spectroscopy, Fourier Transform Infrared; D013537:Sutures; D014332:Tropocollagen
chemical_list: D001672:Biocompatible Materials; D014332:Tropocollagen; D002686:Chitin; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D003094:Collagen; D048271:Chitosan