High frequency of altered HLA class I phenotypes in laryngeal carcinomas.
The exact frequency of HLA class I losses in human tumors is unknown. We have previously shown that primary breast and colorectal carcinomas frequently lose HLA class I molecules (88% and 73%, respectively). Now we report that this phenomenon is also a frequent event in laryngeal carcinomas. Of a total of 76 laryngeal carcinomas analyzed, 66% of the tumors showed an alteration in HLA class I phenotype. These altered HLA phenotypes were classified as total HLA loss (10.52%) (phenotype I); HLA-A locus-specific loss (13.15%) (phenotype IIIa); HLA-B locus-specific loss (10.52%) (phenotype IIIb); HLA allelic loss (27.63%) (phenotype IV); and HLA-A and B locus loss (3.9%). Comparison of histopathological parameters with HLA expression showed that poorly differentiated tumors had the lowest levels of HLA class I expression (p < 0.05).
Cabrera
T
T
Departamento de Análisis Clínicos, Universidad de Granada, Spain.
Salinero
J
J
Fernandez
M A
MA
Garrido
A
A
Esquivias
J
J
Garrido
F
F
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000235:genetics / Q000302:isolation & purification*; D002277:Carcinoma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006680:HLA Antigens / Q000235:genetics / Q000302:isolation & purification*; D015234:HLA-A Antigens / Q000235:genetics / Q000302:isolation & purification; D015235:HLA-B Antigens / Q000235:genetics / Q000302:isolation & purification; D015236:HLA-C Antigens / Q000235:genetics / Q000302:isolation & purification; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000302:isolation & purification*; D006650:Histocompatibility Testing; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D019656:Loss of Heterozygosity; D009092:Mucous Membrane / Q000276:immunology; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I