Changes in plasma norepinephrine and endothelin levels and metabolic profile after AT1-receptor blockade in human hypertension.
In essential hypertensive subjects, acute and chronic administration of losartan was followed by favorable neurohormonal (norepinephrine, endothelin-1) and metabolic changes (microalbuminuria).
Rodriguez-Garcia
J L
JL
Department of Medicine, Hospital General La Mancha Centro, Alcazar de San Juan, Spain. jlgarcia@serconet.com
Paule
A
A
Dominguez
J
J
Garcia-Escribano
J R
JR
Vazquez
M
M
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*
D000959:Antihypertensive Agents; D019332:Endothelin-1; D019808:Losartan; D009638:Norepinephrine