Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.
Spectinomycin resistance in clinical isolates of Neisseria meningitidis and Neisseria gonorrhoeae was found to be due to mutations G1064C and C1192U (Escherichia coli numbering) in 16S rRNA genes, respectively.
Galimand
M
M
Unité des Agents Antibactériens, Institut Pasteur, 75724 Paris Cedex 15, France. galimand@pasteur.fr
Gerbaud
G
G
Courvalin
P
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000235:genetics*; D009345:Neisseria meningitidis / Q000187:drug effects / Q000235:genetics*; D017354:Point Mutation; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D000198:Spectinomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D000198:Spectinomycin