Two novel secoergosterols from the fungus Tylopilus plumbeoviolaceus.
Two novel secoergosterols, 3beta-hydroxy-8alpha,9alpha-oxido-8, 9-secoergosta-7,9(11),22-triene (tylopiol A) (1) and 3beta-hydroxy-8alpha,9alpha-oxido-8,9-secoergosta-7,22 -dien-12-one (tylopiol B) (2), were isolated from the fresh fruit bodies of Tylopilus plumbeoviolaceus, along with three known compounds, ergosta-7,22-dien-3beta-ol, uridine, and allitol. Their structures were elucidated by NMR techniques, including (1)H NMR, (13)C NMR, HMQC, HMBC, and MS. The structure and stereochemistry of compound 1 were demonstrated by X-ray crystallography.
Wu
S H
SH
Laboratory of Phytochemistry, Kunming Institute of Botany, The Chinese Academy of Sciences, Yunnan, People's Republic of China.
Luo
X D
XD
Ma
Y B
YB
Liu
J K
JK
Wu
D G
DG
Zhao
B
B
Lu
Y
Y
Zheng
Q T
QT
D000363:Agaricales / Q000737:chemistry*; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D012632:Secosteroids / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D012632:Secosteroids; C409629:tylopiol A; C409630:tylopiol B; D004875:Ergosterol