[The importance of the use of selenium in the role of an antioxidant in preventing cardiovascular diseases].
The evaluation of the results of the oxygen free radicals (RLO2) formation is a current subject in biology and medicine. The oxidative stress, which is the altering of the balance between the higher activity of oxygen and the enzymatic or nonenzymatic protection systems, may be one of the causes that starts and aggravates a disease. In this context, the supplementation of the diet with selenium, superoxide dismutase, vitamins A, C, E, is considered a primary prevention measure (for the apparently healthy persons) and a secondary one (for those with advancing forms of disease) that is both efficient and modern by utilization of some "drug-food" products. The transversal study realized on a group of 39 blood donors presence of the cardiovascular risk determined by the raising of the prevalence of some atherogenic factors (active smoking, hypercholesterolemia) which is also expressed by the lowering of the level of some oxidative stress indicators (glutathione peroxidase--GSH-Px < 0.139 moli/ml and catalase < 2.20 U/ml). The simultaneous low intake of selenium from the central drinking water supplies in the city of Iaşi (0.1-1 g/l) has permitted us to consider necessary the diet supplementation both with foods rich in vitamins with an antioxidant role and with specific medication with selenium, as a protective micro-element.
Azoicăi
D
D
Disciplina de Epidemiologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Ivan
A
A
Brădăţean
M
M
Pavel
M
M
Jerca
L
L
Iacobovici
A
A
Popovici
I
I
Gheorghiţă
N
N
D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000627:therapeutic use*; D001782:Blood Donors; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D005609:Free Radicals / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D011379:Prognosis; D012307:Risk Factors; D012383:Romania; D012643:Selenium / Q000627:therapeutic use*
D000975:Antioxidants; D005609:Free Radicals; D008055:Lipids; D012643:Selenium