Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors.
A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test after initiating HAART (P=0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P=0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.
Sacktor
N C
NC
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA.
Skolasky
R L
RL
Lyles
R H
RH
Esposito
D
D
Selnes
O A
OA
McArthur
J C
JC
D015526:AIDS Dementia Complex / Q000188:drug therapy* / Q000821:virology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D007839:Functional Laterality; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006679:HIV Seropositivity; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000188:drug therapy* / Q000209:etiology; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011597:Psychomotor Performance / Q000187:drug effects; D019562:Viral Load
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors