Enhancement of HIV type 1 antigen-specific CD4+ T cell memory in subjects with chronic HIV type 1 infection receiving an HIV type 1 immunogen.
We examined HIV-1 specific memory helper T immune responses in chronically HIV-infected subjects who received an immune-based therapy (HIV-1 immunogen, Remune). Subjects in this study exhibited significant increases (p < 0.05) in the frequency of helper T memory cells expressing interferon gamma (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) in response to HIV-1 antigens in vitro. The frequencies of HIV-specific memory T cells increased after successive immunizations and exhibited a correlation with the standard tritiated thymidine incorporation lymphocyte proliferation assay (r = 0.72, p < 0.0008). These results support the notion that HIV-specific memory immune responses can be stimulated in subjects with chronic HIV infection. Further investigations are warranted to determine whether the induction of such responses is associated with virologic control.
Maino
V C
VC
Becton Dickinson Immunocytometry Systems, San Jose, California 95131, USA.
Suni
M A
MA
Wormsley
S B
SB
Carlo
D J
DJ
Wallace
M R
MR
Moss
R B
RB
D016915:AIDS Vaccines / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D002908:Chronic Disease; D005434:Flow Cytometry; D016655:HIV Core Protein p24 / Q000627:therapeutic use; D015699:HIV Envelope Protein gp120 / Q000627:therapeutic use; D015658:HIV Infections / Q000276:immunology / Q000628:therapy* / Q000821:virology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007371:Interferon-gamma / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016915:AIDS Vaccines; D016655:HIV Core Protein p24; D015699:HIV Envelope Protein gp120; C098825:HIV-1 immunogen, incomplete Freund's adjuvant; D014409:Tumor Necrosis Factor-alpha; C105086:remune; D007371:Interferon-gamma