title: Mast cells and dendritic cells in basal cell carcinoma stroma.
abstract: BACKGROUND
  The interaction of tumors with the surrounding stroma has become an important topic in tumor biology. Basal cell carcinoma (BCC) stroma has been characterized as hypervascular and rich in mast cells. The presence of dermal dendrocytes thought to have both antigen presenting and wound healing functions has recently been reported in BCC stroma. GP1b-alpha is a newly described vascular adhesion molecule with potential significance in tumor biology.
  
  
  OBJECTIVE
  To further characterize the cellular phenotype of BCC stroma.
  
  
  METHODS
  Eleven BCCs (8 nodular, 2 sclerosing, 1 adenoid-cystic) were examined using immunohistochemical techniques for the presence of antigens specific to vascular endothelium, mast cells, and dermal dendrocytes.
  
  
  RESULTS
  The stroma of all BCCs demonstrated increased vascularity, increased numbers of mast cells, and increased numbers of dermal dendrocytes expressing both CD34 and GP1b-alpha adjacent to tumor nests. No differences in antigen expression were observed between histologic subtypes of BCC.
  
  
  CONCLUSIONS
  The close proximity of stromal mast cells and dermal dendrocytes surrounding BCC nests suggests a biologically significant interaction. The pattern observed is similar to that observed in healing wounds.
authors.affiliation: Department of Dermatology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Humphreys
authors.forename: M R
authors.initials: MR
authors.lastname: Monteiro
authors.forename: G F
authors.initials: GF
authors.lastname: Murphy
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology*; D003713:Dendritic Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008407:Mast Cells / Q000473:pathology*; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D018952:Antigens, CD34; D019038:Platelet Glycoprotein GPIb-IX Complex