The analysis of basic and acidic compounds using non-aqueous CE and non-aqueous CE-MS.
It has been shown that non-aqueous capillary electrophoresis (NACE) can provide improved separations in comparison to those obtained using conventional CE under aqueous conditions (ACE). Previous work carried out in our laboratories involving initial investigations into the technique have been reported. Based on the findings of that work it was possible to separate a variety of basic pharmaceuticals from selected impurities and to obtain the successful separation of some hydrophobic sulphonic acids. The successful coupling of NACE to mass spectrometry (NACE-MS) has also been demonstrated.
Senior
J
J
Analytical Sciences, SB Pharmaceuticals, New Frontiers Science Park, Harlow, UK. john_p_senior@sbphrd.com
Rolland
D
D
Tolson
D
D
Chantzis
S
S
De Biasi
V
V
D000929:Antidepressive Agents, Tricyclic / Q000302:isolation & purification; D002395:Catecholamines / Q000302:isolation & purification; D003891:Desipramine / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D007099:Imipramine / Q000302:isolation & purification; D013058:Mass Spectrometry / Q000379:methods; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*
D000929:Antidepressive Agents, Tricyclic; D002395:Catecholamines; D004364:Pharmaceutical Preparations; D007099:Imipramine; D003891:Desipramine