title: Diagnostic accuracy of needle biopsy of uterine leiomyosarcoma.
abstract: We previously reported on the efficacy of transcervical needle biopsy of a uterine muscle tumor. In this study, to examine diagnostic accuracy of our needle biopsy with small specimen size, previous slide preparations were used from 8 cases diagnosed with leiomyosarcoma and from 24 post-operative leiomyoma cases. Each tissue specimen was examined through needle biopsy-sized slit that had been randomly positioned over the slide. Three predictors: mitotic index, cytologic atypism, and tumor cell necrosis were evaluated on a 3-point scale (0, 1, or 2 points). When the diagnostic cut-off value was set to two, the sensitivity was 92.5% and the specificity was 100%.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shibata
authors.forename: N
authors.initials: N
authors.lastname: Kawamura
authors.forename: F
authors.initials: F
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Ichimura
authors.forename: A
authors.initials: A
authors.lastname: Tsujimura
authors.forename: K
authors.initials: K
authors.lastname: Minakuchi
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008940:Mitotic Index; D009336:Necrosis; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014594:Uterine Neoplasms / Q000473:pathology*; D014599:Uterus / Q000166:cytology / Q000473:pathology