A new human member of the MYST family of histone acetyl transferases with high sequence similarity to Drosophila MOF.
We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic of other MYST family histone acetyltransferases. Based on hMOF's chromodomain, we discuss possible interactions with other proteins.
Neal
K C
KC
Department of Biology, Emory University, Atlanta, GA 30322, USA.
Pannuti
A
A
Smith
E R
ER
Lucchesi
J C
JC
D000123:Acetyltransferases / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D004303:Dosage Compensation, Genetic; D029721:Drosophila Proteins; D051548:Histone Acetyltransferases; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D014162:Transfection
D029721:Drosophila Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C496553:KAT7 protein, human; C496552:KAT8 protein, human; C111063:mof protein, Drosophila