title: Upregulation of bradykinin B1-receptor expression after myocardial infarction.
abstract: To determine the influence of the myocardial infarction (MI) on bradykinin B1-receptor (B1R) regulation, we studied its expression in the left ventricle (LV) after MI. Rats were submitted to a permanent occlusion of the left coronary artery. Six hours, 24 h and 6 days after MI or after sham operation, left ventricular pressure (LVP) and dP/dt(max) were measured. LV-total RNA was extracted and B1R expression was analysed by a RNase-protection assay (each group n = 6). LVP and dP/dt(max) were impaired at all time points after MI. Basal B1R expression was not detectable in controls. Six hours after MI, the B1R expression was upregulated and reached a maximum 24 h after MI (4 fold vs. 6 h). Six days post-MI, B1R expression returned to levels found 6 h after MI. These data are the first demonstration for an induced myocardial B1R expression in an in vivo model of MI.
authors.affiliation: Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Germany. tsch@zedat.fu-Berlin.de
authors.forename: C
authors.initials: C
authors.lastname: Tschöpe
authors.forename: S
authors.initials: S
authors.lastname: Heringer-Walther
authors.forename: M
authors.initials: M
authors.lastname: Koch
authors.forename: F
authors.initials: F
authors.lastname: Spillmann
authors.forename: M
authors.initials: M
authors.lastname: Wendorf
authors.forename: E
authors.initials: E
authors.lastname: Leitner
authors.forename: H P
authors.initials: HP
authors.lastname: Schultheiss
authors.forename: T
authors.initials: T
authors.lastname: Walther
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006439:Hemodynamics; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin / Q000096:biosynthesis* / Q000378:metabolism; D015854:Up-Regulation; D016277:Ventricular Function, Left
chemical_list: D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin