Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.
A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.
Clark
R F
RF
Infectious Diseases Research, Abbott Laboratories, Abbott Park, IL 60064-3537, USA. rick.f.clark@abbott.com
Ma
Z
Z
Wang
S
S
Griesgraber
G
G
Tufano
M
M
Yong
H
H
Li
L
L
Zhang
X
X
Nilius
A M
AM
Chu
D T
DT
Or
Y S
YS
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D004917:Erythromycin