title: Complex investigation of Graves'-Basedow disease: case report.
abstract: This paper relate a patient case, age 42, female sex, which was complex immuno-morphologically investigated, on thyroid fragments, surgically obtained. The patient was previously diagnosed with Graves'-Basedow disease; the relapses after conventional therapy, orientated the case for surgical treatment--subtotal thyroidal resection. Using polyclonal and monoclonal antibodies, we may confirm that the disease is fully active. Graves'-Basedow disease is the most common form of autoimmune thyroiditis, responsible for the majority of the cases of hyperthyroidism, affecting young women. It was suspected, many years ago and recently demonstrated that the hyperthyroidism is involved in the development of the autoimmune response, by increasing the immune reaction of the organism. Some effects of the antithyroid drugs are mediated by the decrease of the specific stimulator antibodies (long-acting thyroid stimulator), commonly found in Graves'-Basedow disease.
authors.affiliation: Histology Department, Faculty of Medicine, University of Medicine and Pharmacy Gr. T. Popa, Iaşi.
authors.forename: I C
authors.initials: IC
authors.lastname: Luca
authors.forename: M C
authors.initials: MC
authors.lastname: Bene
authors.forename: C
authors.initials: C
authors.lastname: Cotuţiu
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D002231:Carbimazole / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006111:Graves Disease / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology / Q000628:therapy; D006801:Humans; D012008:Recurrence; D013961:Thyroid Gland / Q000276:immunology / Q000473:pathology; D013965:Thyroidectomy
chemical_list: D013956:Antithyroid Agents; D002231:Carbimazole