title: Fungicidal activity of natural and synthetic sesquiterpene lactone analogs.
abstract: Fungicidal activity of 36 natural and synthetic sesquiterpene lactones with guaianolide, trans, trans-germacranolide, cis, cis-germacranolide, melampolide, and eudesmanolide carbon skeletons was evaluated against the phytopathogenic fungi Colletotrichum acutatum, C. fragariae, C. gloeosporioides, Fusarium oxysporum, Botrytis cinerea, and Phomopsis sp. Dose-response data for the active compounds dehydrozaluzanin C, dehydrocostuslactone, 5alpha-hydroxydehydrocostuslacone, costunolide, and zaluzanin C are presented. A new 96-well microbioassay procedure for fast and easy evaluation of antifungal activity was used to compare these compounds with commercial fungicide standards. Some structure-activity conclusions are also presented.
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, University, MS 38677, USA. dwedge@olemiss.edu
authors.forename: D E
authors.initials: DE
authors.lastname: Wedge
authors.forename: J C
authors.initials: JC
authors.lastname: Galindo
authors.forename: F A
authors.initials: FA
authors.lastname: Macías
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D012717:Sesquiterpenes