Microglial activation and neuronal apoptosis in Bornavirus infected neonatal Lewis rats.
Lewis rats neonatally infected with Borna disease virus have a behavioral syndrome characterized by hyperactivity, movement disorders, and abnormal social interactions. Virus is widely distributed in brain; however, neuropathology is focused in dentate gyrus, cerebellum, and neocortex where granule cells, Purkinje cells and pyramidal cells are lost through apoptosis. Although a transient immune response is present, its distribution does not correlate with sites of damage. Neuropathology is instead colocalized with microglial proliferation and expression of MHC class I and class II, ICAM, CD4 and CD8 molecules. Targeted pathogenesis in this system appears to be linked to microglial activation and susceptibility of specific neuronal populations to apoptosis rather than viral tropism or virus-specific immune responses.
Weissenböck
H
H
Emerging Diseases Laboratory, University of California, Irvine 92697-4292, USA.
Hornig
M
M
Hickey
W F
WF
Lipkin
W I
WI
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000941:Antigens / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D001890:Borna Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D001891:Borna disease virus / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D017628:Microglia / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009698:Nucleoproteins / Q000378:metabolism; D010641:Phenotype; D012367:RNA, Viral / Q000378:metabolism; D051381:Rats; D011917:Rats, Inbred Lew / Q000502:physiology*; D013997:Time Factors; D014018:Tissue Distribution; D014764:Viral Proteins / Q000378:metabolism
D000941:Antigens; D009698:Nucleoproteins; D012367:RNA, Viral; D014764:Viral Proteins