Scalarane and homoscalarane compounds from the nudibranchs Glossodoris sedna and Glossodoris dalli: chemical and biological properties.
A series of homoscalarane and scalarane compounds (2-7) have been isolated from two distinct species of Pacific Glossodoris nudibranchs. The structure and elucidation of the relative stereochemistry of the new metabolites 2 and 3 were obtained by spectroscopic methods. Compound 2 was ichthyotoxic at 0.1 ppm against Gambusia affinis and showed moderate activity (IC(50) 18 microM) to inhibit mammalian phospholipase A(2).
Fontana
A
A
Istituto per la Chimica di Molecole di Interesse Biologico (ICMIB)(1) del CNR, via Toiano 6, 80072 Arco Felice, Napoli, Italy. a.fontana@icmib.na.cnr.it
Mollo
E
E
Ortea
J
J
Gavagnin
M
M
Cimino
G
G
D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D005399:Fishes; D009682:Magnetic Resonance Spectroscopy; D008974:Mollusca / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013261:Sterols / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D014020:Tissue Extracts / Q000737:chemistry
C409626:12-deacetyl-23-acetoxy-20-methylscalaradial; D013261:Sterols; D014020:Tissue Extracts