Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line.
Two flavonoids, quercetin-3-O-beta-D-glucopyranoside (1) and quercetin-3,7-di-O-beta-D-glucopyranoside (2), were isolated from the leaves of Morus alba (Moraceae). These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2 x 10(-4) M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens. These flavonoids exhibited significant free radical scavenging effects on 1,1-diphenyl-2-picryl-hydrazyl radical.
Kim
S Y
SY
Graduate School of East-West Medical Science, Kyunghee University, Seoul, Korea.
Gao
J J
JJ
Kang
H K
HK
D002454:Cell Differentiation / Q000187:drug effects*; D002469:Cell Separation; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D018515:Plant Leaves / Q000737:chemistry*; D013057:Spectrum Analysis
D005419:Flavonoids