The relationship between metal-metal distance of two metal ions chelated complex and RNA cleavage activity.
We prepared a series of ligands possessing two binding sites for metal coordination: in each ligand molecule, two binding sites with the same functionality (2,2'-dipicolylamino group) were placed at the of various methyl arenes. Thus, the distances between the metal binding sites were different from ligand to ligand. We examined the rate of the hydrolysis of RNA dimer catalyzed by La3+ ion binuclear complexes of the ligands. The catalytic activity of the binuclear complexes increased as the distance between the metal binding sites was decreased.
Kawahara
S
S
Department of Physical Chemistry, National Institute of Materials and Chemical Research, Agency of Industrial Science and Technology, MITI, Tsukuba Science City, Japan.
Uchimaru
T
T
D001665:Binding Sites; D002614:Chelating Agents / Q000737:chemistry*; D019281:Dimerization; D015226:Dinucleoside Phosphates / Q000737:chemistry; D006868:Hydrolysis; D007811:Lanthanum; D008024:Ligands; D010847:Picolines; D012313:RNA / Q000737:chemistry*
D002614:Chelating Agents; D015226:Dinucleoside Phosphates; D008024:Ligands; D010847:Picolines; C028521:lanthanum chloride; C006412:adenylyl-(3'-5')-adenosine; D012313:RNA; D007811:Lanthanum