title: Alterations in rat's brain capillaries in a model of focal cerebral necrosis.
abstract: Focal brain compression causes cerebral tissue damage. In this study we followed alterations in capillary ultrastructure in the rat cortex and neurohypophysis caused by 40 mm Hg compression for 15 minutes. One day after experiment we observed clogging of capillaries, accumulation of collagen fibrills under the basement membrane and necrosis or apoptosis of endothelial cells. Four days after it the basement membrane was multiplicated, blurred and thickened. In the neurohypophysis the formation of vessels lined with the atypical continuous endothelium was seen. There was also evidence for the migration of pericytes through the blurred basement membrane and the differentiation of pericytes into endothelial cells. Thus, vascular injury in the compressed brain is followed by a highly ordered sequence of processes in the basement membrane and perivascular cells leading to capillary repair.
authors.affiliation: Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences.
authors.forename: M
authors.initials: M
authors.lastname: Frontczak-Baniewicz
authors.forename: H
authors.initials: H
authors.lastname: Olszewska
authors.forename: R
authors.initials: R
authors.lastname: Gadamski
authors.forename: I
authors.initials: I
authors.lastname: Barskow
authors.forename: B
authors.initials: B
authors.lastname: Gajkowska
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000473:pathology; D002196:Capillaries / Q000648:ultrastructure; D002465:Cell Movement; D002540:Cerebral Cortex / Q000473:pathology*; D004195:Disease Models, Animal; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D020286:Pericytes; D010904:Pituitary Gland, Posterior / Q000098:blood supply* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar