[The effect of verapamil on the resumption of meiosis and the formation of the first polar body by mouse oocytes in vitro].
Resumption of the first meiotic division and extrusion of the first polar body from the cumulus enclosed and cumulus-free oocytes isolated from mouse ovaries in diestrus, proestrus, estrus (I and II) were registered in the medium containing various concentration of verapamil. In this study, the competence of the oocytes to resumed the first meiotic division and to extruded the first polar body were dependent from verapamil concentration (in proestrus and estrus I) and from cumulus cell presence.
Ianchiĭ
R I
RI
A. A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Blashkiv
T V
TV
Voznesens'ka
T Iu
TIu
Portnychenko
A H
AH
Sanduliak
V N
VN
Bidzilia
Iu P
IuP
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D009865:Oocytes / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D014700:Verapamil