Hematological responses to hydroxyurea therapy in multitransfused thalassemic children.
Fifteen multi-transfused thalassemic children between 3-6 years of age (seven boys and eight girls) were administered hydroxyurea for 5 days and three such cycles were repeated at 15 days interval. Rise in hemoglobin levels was observed in 13, 8 and 7 cases, while rise in mean hemoglobin F was seen in 8, 11 and 10 cases following 1st, 2nd and 3rd course of hydroxyurea therapy respectively. Rise in hemoglobin level was associated with transient rise in fetal hemoglobin level. Though the changes in mean hemoglobin levels and hemoglobin F levels were statistically insignificant, a definite trend of rise in hemoglobin and hemoglobin F was observed.
Choudhry
V P
VP
Department of Hematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
Lal
A
A
Pati
H P
HP
Arya
L S
LS
D001803:Blood Transfusion / Q000379:methods; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis / Q000187:drug effects*; D005500:Follow-Up Studies; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage*; D008297:Male; D016896:Treatment Outcome; D017086:beta-Thalassemia / Q000097:blood / Q000188:drug therapy* / Q000628:therapy
D004791:Enzyme Inhibitors; D005319:Fetal Hemoglobin; D006918:Hydroxyurea