title: [Sarcoidosis differentially diagnosed from mediastinal tumor by thoracoscopic biopsy].
abstract: A 46-year-old man presented with swallowing difficulty and dyspnea when in the supine position. Chest X-ray and computed tomographic (CT) films disclosed left pleural effusion and a tumor shadow extending invasively from superior to anterior mediastinum around the heart and large arteries. These observations called for a differential diagnosis from malignant lymphoma, invasive thymoma, and small cell carcinoma. Bronchofiberscopy and percutaneous tumor biopsy were performed, but the findings were inconclusive. Thoracoscopic biopsy yielded a diagnosis of sarcoidosis. No extrathoracic lesions were detected. Corticosteroid therapy (30 mg/day of prednisolone) was started. After 6 months of treatment (7.5 mg/day of prednisolone), the tumor shadow was reduced in size and the patient's swallowing difficulty and dyspnea subsided. This was a rare case of sarcoidosis extending invasively around the heart and large arteries, and that needed to be differentiated from mediastinal tumor. Thoracoscopic biopsy should be actively enlisted as a diagnostic procedure in difficult cases of this kind.
authors.affiliation: First Department of Internal Medicine, Nihon University, School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakayama
authors.forename: H
authors.initials: H
authors.lastname: Hachisuka
authors.forename: S
authors.initials: S
authors.lastname: Furuichi
authors.forename: H
authors.initials: H
authors.lastname: Akusawa
authors.forename: C
authors.initials: C
authors.lastname: Omori
authors.forename: Y
authors.initials: Y
authors.lastname: Kayama
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: K
authors.initials: K
authors.lastname: Omori
authors.forename: T
authors.initials: T
authors.lastname: Horie
mesh_terms: D001706:Biopsy / Q000379:methods; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000175:diagnosis*; D008479:Mediastinal Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D012507:Sarcoidosis / Q000175:diagnosis*; D020775:Thoracic Surgery, Video-Assisted