Hepatitis C virus (HCV) NS5A protein: role in HCV replication and resistance to interferon-alpha.
The hepatitis C virus (HCV) non-structural (NS) 5A protein appears to play an important regulatory role on viral replication and could also be involved in viral pathogenesis. HCV resistance to interferon is a complex mechanism involving multiple causes, among which certain NS5A functions could play a role.
Pawlotsky
J M
JM
Department of Bacteriology and Virology and INSERM U99, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
D004351:Drug Resistance; D016174:Hepacivirus / Q000187:drug effects / Q000502:physiology*; D016898:Interferon-alpha / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000502:physiology*; D014779:Virus Replication; D012324:RNA-Dependent RNA Polymerase
D016898:Interferon-alpha; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase