title: Cytotoxic prenylxanthones from Garcinia bracteata.
abstract: Bioassay-guided fractionation of a leaf extract of G. bracteata has yielded six new prenylxanthones, bractatin (1), isobractatin (2), 1-O-methylbractatin (3), 1-O-methylisobractatin (4), 1-O-methyl-8-methoxy-8,8a-dihydrobractatin (5), and 1-O-methylneobractatin (6). The structures of these compounds have been elucidated by spectroscopic means (NMR, MS), literature data, and X-ray crystallographic analysis of 2. These compounds possess significant cytotoxicity against the KB cell line.
authors.affiliation: Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Thoison
authors.forename: J
authors.initials: J
authors.lastname: Fahy
authors.forename: V
authors.initials: V
authors.lastname: Dumontet
authors.forename: A
authors.initials: A
authors.lastname: Chiaroni
authors.forename: C
authors.initials: C
authors.lastname: Riche
authors.forename: M V
authors.initials: MV
authors.lastname: Tri
authors.forename: T
authors.initials: T
authors.lastname: Sévenet
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004791:Enzyme Inhibitors; D014966:Xanthenes; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase