title: [Biologic monitoring of carbon disulfide: role of glutathione].
abstract: Work goal is a critical analysis of the possibility of using TTCA as a future marker for next environmental limit values which will be probably fixed to much lower levels. Four metabolites have been identified in the urines of CS2 exposed subjects, exactly: thiocarbamide, 2-mercaptothiazolinone, 2-thiothiazolidine-4-carboxylic acid (TTCA), 2-oxothiazolidine-4-carboxylic acid. TTCA represents about the 6% of absorbed CS2 during occupational exposure. TTCA discovery in the urines of CS2 exposed workers (an heterocyclic compound which develops in vivo through direct reaction between CS2 and Glutatione) allowed a more specific approach to exposure assessment. The end-shift urine TTCA concentration seems to be in strict relationship with CS2 absorbed amount. In 1998 ACGIH maintained the 1997 limit value (TLV-TWA 10 ppm). In the 1997 DFG cut down the limit value in half (MAK 5 ppm), while, until 1996, it accepted the ACGIH value.
authors.affiliation: Centro Ricerche di Fisiopatologia e Sicurezza del Lavoro dell'Università di Pavia.
authors.forename: S
authors.initials: S
authors.lastname: Ghittori
authors.forename: L
authors.initials: L
authors.lastname: Abatangelo
authors.forename: M
authors.initials: M
authors.lastname: Imbriani
mesh_terms: D002246:Carbon Disulfide / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D013844:Thiazoles / Q000652:urine*; D053778:Thiazolidines
chemical_list: D013844:Thiazoles; D053778:Thiazolidines; C031677:2-thioxo-4-thiazolidinecarboxylic acid; D005978:Glutathione; D002246:Carbon Disulfide