Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism.
We investigated the intercellular adhesion molecule-1 (ICAM-1) gene polymorphism in 90 patients with young-onset type 1 diabetes, 74 with adult-onset type 1 diabetes, and 171 control subjects. The distribution of C-T genotypes and allele frequencies in exon 6 of the ICAM-1 gene was significantly different between adult-onset type 1 diabetes patients and controls (chi(2) = 9.76, p = 0.0076), and between patients with adult-onset and young-onset type 1 diabetes (chi(2) = 11.28, p = 0.0036). In contrast, we failed to detect any association between patients with young-onset type 1 diabetes and controls. Our data suggest that ICAM-1 exon 6 gene polymorphism affects the age-at-onset of type 1 diabetes and that different pathogenetic mechanisms may exist between young-onset and adult-onset type 1 diabetes.
Nishimura
M
M
Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan.
Obayashi
H
H
Maruya
E
E
Ohta
M
M
Tegoshi
H
H
Fukui
M
M
Hasegawa
G
G
Shigeta
H
H
Kitagawa
Y
Y
Nakano
K
K
Saji
H
H
Nakamura
N
N
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007564:Japan; D008875:Middle Aged; D011110:Polymorphism, Genetic
D018799:Intercellular Adhesion Molecule-1