[Preliminary assessment of felbamate effect on the cerebral bioelectrical activity in children with refractory epilepsy].
Influence Felbamate on the cerebral bioelectric activity (EEG) in the group of 31 children (18 with syndrome Lennox-Gastaut, 13 with partial epilepsy) with refractory epilepsy was investigated. In the waking EEG was visually analysed: 1. Abnormalities distribution and morphology with special consideration of slow waves, sharp elements and paroxysmal character of discharges. 2. Influence of Felbamate on the duration time of discharges. 3. Range dominant frequency and length of segments (with non-disturbed topographic differentiation) of background activity EEG. During therapy the results showed more often EEG improvement among children with syndrome Lennox-Gastaut (near 70%) than in children with partial refractory epilepsy (near 30%). The EEG results correlated positively with the clinical improvement. In the both group of epilepsy background activity improvement had a statistical significance. In sleep EEG any influence of Felbamate on the sleep spindles was observed. No observation about increase beta activity in waking and sleep EEG records was noted.
Pakszys
M
M
Zakład Elektrofizjologii Dzieci i Młodziezy, Instytutu Matki i Dziecka.
Rusek
G
G
Kuszczak
B
B
Szamotulska
K
K
Mazur
J
J
D000293:Adolescent; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000187:drug effects*; D004827:Epilepsy / Q000188:drug therapy*; D000078328:Felbamate; D005260:Female; D006801:Humans; D008297:Male; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000494:pharmacology* / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D014851:Wakefulness / Q000502:physiology
D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D000078328:Felbamate