title: Flavonol-cinnamate cycloadducts and diamide derivatives from Aglaia laxiflora.
abstract: Leaf extracts of the Malaysian plant Aglaia laxiflora provided two cytotoxic compounds, a new rocaglaol rhamnoside (1), a known rocaglaol (2), new (but inactive) flavonol-cinnamaminopyrrolidine adducts (3-6), and their probable biosynthetic precursors (7 and trimethoxyflavonol). All structures were elucidated primarily by 2D NMR spectroscopy. The structure and stereochemistry of aglaxiflorin A (3) were confirmed by single-crystal X-ray crystallography.
authors.affiliation: Department of Chemistry, National University of Singapore.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Xu
authors.forename: X H
authors.initials: XH
authors.lastname: Wu
authors.forename: B K
authors.initials: BK
authors.lastname: Tan
authors.forename: Y H
authors.initials: YH
authors.lastname: Lai
authors.forename: J J
authors.initials: JJ
authors.lastname: Vittal
authors.forename: Z
authors.initials: Z
authors.lastname: Imiyabir
authors.forename: L
authors.initials: L
authors.lastname: Madani
authors.forename: K S
authors.initials: KS
authors.lastname: Khozirah
authors.forename: S H
authors.initials: SH
authors.lastname: Goh
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006575:Heterocyclic Compounds, 3-Ring / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D008296:Malaysia; D013058:Mass Spectrometry; D051379:Mice; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006575:Heterocyclic Compounds, 3-Ring