title: Magnetic resonance-based vertebral morphometry of the thoracic spine: age, gender and level-specific influences.
abstract: OBJECTIVE
  The aim of this study was to examine age, gender, and segmental trends in thoracic vertebral body shape, utilising thoracic spine magnetic resonance images involving an age range spanning the life span.
  
  
  METHODS
  A quantitative, cross-sectional, retrospective study design involving a sample of convenience.
  
  
  BACKGROUND
  Thoracic vertebral shape data are commonly derived from radiographic resources. The non-ionising properties of magnetic resonance imaging and availability of digital data for image analysis suggest potential for MR-based morphometric studies. For the thoracic spine, there is limited vertebral shape data on males, while few studies have examined the pattern of age-related changes across the life span.
  
  
  METHODS
  Morphometry was performed on 220 mid sagittal T1-weighted MR images using image analysis software. Three indices of vertebral shape were utilised: the antero-posterior height ratio or anterior wedge index, mid-posterior height ratio or biconcavity index, and ratio of posterior vertebral height to mid antero-posterior diameter or compression index.
  
  
  RESULTS
  Different segmental patterns were noted for the vertebral shape indices. Significantly lower mean values were noted in males for the compression index. Age trends were significant, with a linear age-related decline demonstrated for the anterior wedge and biconcavity indices, and a quadratic trend noted for the compression index.
  
  
  CONCLUSIONS
  Thoracic vertebral body shape may be uniquely described using specific shape indices, for examining various segmental, gender and age-associated changes.
  
  
  CONCLUSIONS
  These results suggest the importance of defining specific reference criteria for thoracic vertebral body shape indices, particularly age-related data encompassing a wide age range. Magnetic resonance studies enable interpretation of vertebral shape data in relation to the wide spectrum of pathologies afflicting the thoracic spine, without the concerns of ionising radiation.
authors.affiliation: Department of Surgery, Centre for Musculoskeletal Studies, The University of Western Australia. kps@cyllene.uwa.edu.au
authors.forename: S
authors.initials: S
authors.lastname: Goh
authors.forename: R I
authors.initials: RI
authors.lastname: Price
authors.forename: S
authors.initials: S
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Davis
authors.forename: K P
authors.initials: KP
authors.lastname: Singer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012189:Retrospective Studies; D012727:Sex Characteristics; D013904:Thoracic Vertebrae / Q000033:anatomy & histology*