title: Esophageal body length, lower esophageal sphincter length, position and pressure in health and disease.
abstract: We compared esophageal dimensions in control subjects and patients with differing motility disorders and severities of reflux disease. Patients (1108) and healthy controls (36) underwent manometry and 24-h pH monitoring. Subjects were grouped according to pH and manometry data into seven groups. Mean (s.e.m.) esophageal body length is greatest in achalasia [22.41 (0.27) cm] and least in reflux disease [20.06 (0.13) cm, p < 0.05]. Lower esophageal sphincter (LES) pressure is greatest in achalasia [17.46 (1.06) mmHg] and least in reflux disease [6.57 (0.24) mmHg, p < 0.05]. LES length is least in achalasia patients and control subjects. The ratio of intra-abdominal to intrathoracic LES is greatest in achalasia (1.29), no reflux and normal motility group, and controls and least in reflux disease (1.04, p < 0.05). In conclusion, esophageal body length is greatest in achalasia and least in reflux disease. This is associated with caudal movement of the LES in achalasia and cranial movement of the LES in reflux disease, relative to the diaphragm.
authors.affiliation: Department of Surgery, Guy's Hospital, London, UK.
authors.forename: R E
authors.initials: RE
authors.lastname: Marshall
authors.forename: A
authors.initials: A
authors.lastname: Anggiansah
authors.forename: C L
authors.initials: CL
authors.lastname: Anggiansah
authors.forename: W A
authors.initials: WA
authors.lastname: Owen
authors.forename: W J
authors.initials: WJ
authors.lastname: Owen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015154:Esophageal Motility Disorders / Q000175:diagnosis*; D004943:Esophagogastric Junction / Q000033:anatomy & histology* / Q000502:physiology; D004947:Esophagus / Q000033:anatomy & histology* / Q000502:physiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000175:diagnosis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011312:Pressure; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index