Sigmoid ischemia and the inflammatory response following endovascular abdominal aortic aneurysm repair.
OBJECTIVE
To assess the relationship between sigmoid colonic perfusion, endotoxemia, and cytokine generation in patients undergoing elective open repair (OR) or endovascular repair (EVR) of infrarenal abdominal aortic aneurysms (AAA).


METHODS
Ten patients (9 males; average age 67.6 +/- 2.5 years, mean aneurysm diameter 6.9 +/- 0.6 cm) undergoing OR were compared to 10 patients (all males; average age 70.3 +/- 2.6 years, mean aneurysm diameter 6.5 +/- 0.5 cm) whose repair was performed using the EVR technique. The partial pressure of the carbon dioxide gap (PCO2gap = tissue PCO2 - arterial PCO2) of the sigmoid colonic mucosa was measured using a silicone tonometer to evaluate bowel perfusion. Blood samples were collected into pyrogen-free heparinized tubes for quantification of plasma concentrations of endotoxin, tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) before, during, and after aortic repair.


RESULTS
Patients in the OR group had a significantly greater increase in PCO2gap, suggesting a greater degree of bowel ischemia compared to the EVR group. This was associated with significantly greater postoperative concentrations of endotoxin, TNF-alpha, and IL-6 in the OR group. A significant correlation was found between PCO2gap, IL-6, and postoperative core temperature.


CONCLUSIONS
The results suggest that the degree of bowel ischemia, endotoxemia, and cytokine generation following elective infrarenal AAA reconstruction may be reduced if the endovascular technique is used instead of conventional surgery.
Elmarasy
N M
NM
Department of Vascular and Endovascular Surgery, Queen's Medical Centre, Nottingham, United Kingdom. lab@qmcvascular.demon.co.uk
Soong
C V
CV
Walker
S R
SR
Macierewicz
J A
JA
Yusuf
S W
SW
Wenham
P W
PW
Hopkinson
B R
BR
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D002245:Carbon Dioxide / Q000378:metabolism; D016022:Case-Control Studies; D012809:Colon, Sigmoid / Q000098:blood supply*; D019446:Endotoxemia / Q000209:etiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D015427:Reperfusion Injury / Q000209:etiology* / Q000378:metabolism; D015607:Stents; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002245:Carbon Dioxide