[The participation of L-arginine in correcting the activity of the membrane-transport enzymes Na+,K(+)-, Ca2(+)- and Na(+)-ATPases in experimental hypercholesterolemia].
The influence of precursor of biosynthesis of nitric oxide L-arginine on the level of transport enzymes Na+, K(+)-, Ca(2+)- and Na(+)-ATPases activity under rabbits experimental hypercholesterolemia have been studied. The significant changes in Na+, K(+)-, Ca(2+)- and Na(+)-ATPases activity in different tissues (the cortex of kidney, the endothelium of aorta, the epithelium of small intestine, the liver) had been found for the rabbits with inhibition of the activity of this enzymes to the different levels in all these tissues. Injection of L-arginine during the hypercholesterolemia caused the recovery of Na+, K(+)-, Ca(2+)- and Na(+)-ATPases approximately to the control levels. Obtained results demonstrate that exogenous L-arginine may participate in the correction of the activity of membrane transport enzymes under the condition of the rabbits experimental hypercholesterolemia. The authors discuss the possible mechanisms of L-arginine effect on the studied transport enzymes under the experimental atherosclerosis.
Vavilova
H L
HL
A. A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Prokopenko
O M
OM
Kharlamova
O M
OM
Sahach
V F
VF
D000251:Adenosine Triphosphatases / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001120:Arginine / Q000008:administration & dosage*; D001161:Arteriosclerosis / Q000188:drug therapy / Q000201:enzymology; D000252:Calcium-Transporting ATPases / Q000187:drug effects* / Q000378:metabolism; D027682:Cation Transport Proteins; D004353:Drug Evaluation, Preclinical; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000201:enzymology; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D027682:Cation Transport Proteins; D001120:Arginine; D000251:Adenosine Triphosphatases; C021838:sodium-translocating ATPase; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase