A neuromodulation strategy for rational therapy of complex brain injury states.
We review initial efforts at neuromodulation in the vegetative state and organize several aspects of recent studies of the underlying neurobiology of catastrophic brain injuries. An innovative strategy for patient and target selection for neuromodulation of impaired cognitive function is outlined. Scientific and ethical issues that will attend future efforts to appropriately risk-stratify patients and initiate interventions with therapeutic intent are considered.
Schiff
N D
ND
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA.
Rezai
A R
AR
Plum
F
F
D001921:Brain / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D003071:Cognition; D004599:Electric Stimulation Therapy; D006801:Humans