An unusual nitrogenous terphenyl derivative from fruiting bodies of the basidiomycete Sarcodon leucopus.
A new nitrogenous metabolite with a p-terphenyl core, sarcodonin (3), has been isolated from fruiting bodies of the basidiomycete Sarcodon leucopus. The structure of 3 was determined through a careful study of its peracetate 4, by use of an array of spectroscopic techniques (including (15)N NMR, gradient-enhanced, and reverse-detected 2D NMR experiments) and chemical degradation. ROESY data and molecular mechanics (MM+) calculations led to assignment of the absolute configuration of 4. Compound 3 exhibited moderate cytotoxicity against KB and P-388 tumor cell cultures.
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Istituto CNR per lo Studio delle Sostanze Naturali di Interesse Alimentare e Chimico-Farmaceutico, via del Santuario 110, I-95028 Valverde (CT), Italy.
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D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D013729:Terpenes; C117589:sarcodonin M