title: Cerebrospinal fluid penetration and pharmacokinetics of vancomycin administered by continuous infusion to mechanically ventilated patients in an intensive care unit.
abstract: Cerebrospinal fluid (CSF) penetration and the pharmacokinetics of vancomycin were studied after continuous infusion (50 to 60 mg/kg of body weight/day after a loading dose of 15 mg/kg) in 13 mechanically ventilated patients hospitalized in an intensive care unit. Seven patients were treated for a sensitive bacterial meningitis and the other six patients, who had a severe concomitant neurologic disease with intracranial hypertension, were treated for various infections. Vancomycin CSF penetration was significantly higher (P < 0.05) in the meningitis group (serum/CSF ratio, 48%) than in the other group (serum/CSF ratio, 18%). Vancomycin pharmacokinetic parameters did not differ from those obtained with conventional dosing. No adverse effect was observed, in particular with regard to renal function.
authors.affiliation: Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles University Hospital System, Marseilles, France.
authors.forename: J
authors.initials: J
authors.lastname: Albanèse
authors.forename: M
authors.initials: M
authors.lastname: Léone
authors.forename: B
authors.initials: B
authors.lastname: Bruguerolle
authors.forename: M L
authors.initials: ML
authors.lastname: Ayem
authors.forename: B
authors.initials: B
authors.lastname: Lacarelle
authors.forename: C
authors.initials: C
authors.lastname: Martin
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D012121:Respiration, Artificial; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects / Q000134:cerebrospinal fluid*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin