title: 4-Thiazolidinones: novel inhibitors of the bacterial enzyme MurB.
abstract: 4-Thiazolidinones were synthesized and evaluated for their ability to inhibit the bacterial enzyme MurB. Selected 4-thiazolidinones displayed activity against the enzyme in vitro. This activity, coupled with the design principles of the thiazolidinones, supports the postulate that 4-thiazolidinones may be recognized as diphosphate mimics by a biological selector.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Andres
authors.forename: J J
authors.initials: JJ
authors.lastname: Bronson
authors.forename: S V
authors.initials: SV
authors.lastname: D'Andrea
authors.forename: M S
authors.initials: MS
authors.lastname: Deshpande
authors.forename: P J
authors.initials: PJ
authors.lastname: Falk
authors.forename: K A
authors.initials: KA
authors.lastname: Grant-Young
authors.forename: W E
authors.initials: WE
authors.lastname: Harte
authors.forename: H T
authors.initials: HT
authors.lastname: Ho
authors.forename: P F
authors.initials: PF
authors.lastname: Misco
authors.forename: J G
authors.initials: JG
authors.lastname: Robertson
authors.forename: D
authors.initials: D
authors.lastname: Stock
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: A W
authors.initials: AW
authors.lastname: Walsh
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D002237:Carbohydrate Dehydrogenases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013844:Thiazoles; D002237:Carbohydrate Dehydrogenases; C023215:UDP-N-acetylmuramate dehydrogenase