Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element.
The aminoglycosidic antibiotic, neomycin B, is an inhibitor of the binding of Rev to RRE. This paper reports on the synthesis of analogs of neomycin B as potential anti-HIV compounds designed to function as inhibitors of Rev/RRE binding.
Nishizono
N
N
Department of Chemistry, University of Iowa, Iowa City 52242, USA.
Nair
V
V
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005601:Framycetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015752:Genes, env / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
C411243:5-O-(ethyl-2-(5-amino-5-deoxy-ribofuranosidyl))neamine pentahydrochloride; C411245:5-O-(ethyl-2-(6-amino-6-deoxy-glycopyranosidyl))neamine pentahydrochloride; D019380:Anti-HIV Agents; D014312:Trisaccharides; D005601:Framycetin