Posttraumatic stress disorder and platelet serotonin measures.
The role of serotonin (5HT) in the pathophysiology of posttraumatic stress disorder (PTSD) has been suggested by the overlap in clinical symptoms between PTSD and psychiatric conditions in which a serotonin dysfunction is implicated, as well as by the therapeutic efficiency of 5HT-related drugs (antidepressants, selective serotonin reuptake inhibitors and monoamine oxidase inhibitors) in alleviating symptoms in PTSD. In the present study, the blood platelet, which has been proposed as a peripheral model for the central serotonergic neurons, has been used to search for alterations in 5HT mechanisms in PTSD. Platelet serotonin level and kinetics of serotonin transporter and monoamine oxidase (MAO-B) were assessed in 63 combat-related PTSD patients and 43 sex and age-matched control subjects. A significant reduction in maximal velocity of platelet MAO-B (approx. 30%), with no changes in the enzyme affinity was observed in our patient sample. Conversely, no alterations in kinetic parameters (V(max), K(m)) of platelet serotonin transporter, as well as in platelet 5HT level, were found in the PTSD group.
Cicin-Sain
L
L
Laboratory of Neurochemistry and Molecular Neurobiology, Ruder Boskovic Institute, Bijenicka cesta 54, HR-10000, Zagreb, Croatia. cicinsai@rudjer.irb.hr
Mimica
N
N
Hranilovic
D
D
Balija
M
M
Ljubin
T
T
Makarić
G
G
Folnegović-Smalc
V
V
Jernej
B
B
D000328:Adult; D001792:Blood Platelets / Q000201:enzymology*; D002352:Carrier Proteins / Q000502:physiology; D003130:Combat Disorders / Q000175:diagnosis* / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D008297:Male; D008562:Membrane Glycoproteins / Q000502:physiology; D026901:Membrane Transport Proteins; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000097:blood*; D009419:Nerve Tissue Proteins; D012701:Serotonin / Q000097:blood*; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin; D008995:Monoamine Oxidase