title: Lasers in the treatment of ischaemic heart disease.
abstract: Mounting evidence showing that transmyocardial laser revascularization (TMR) is a safe and effective treatment for angina pectoris arrives just as an increasing number of patients who have undergone angioplasty and coronary artery bypass grafting experience failure with time. TMR, nevertheless, remains controversial. It appears to relieve the symptoms without treating the underlying atherosclerotic disease, and its method of action is unproven. Like angioplasty and coronary bypass, TMR in fact offers palliation rather than a cure for atherosclerotic heart disease. The most sensible current formulations of the therapeutic mechanism of TMR posit a reconfiguration of the microcirculation, with blood shunted from epicardial to endocardial areas. These unresolved issues notwithstanding, TMR benefits patients with end-stage coronary disease and represents a pioneering effort to remodel the microcirculation of patients with arteriosclerotic occlusive disease.
authors.affiliation: Department of Surgery, University of Missouri, School of Medicine, Columbia 65212, USA. jonesjw@health.missouri.edu
authors.forename: J W
authors.initials: JW
authors.lastname: Jones
authors.forename: S E
authors.initials: SE
authors.lastname: Schmidt
authors.forename: B W
authors.initials: BW
authors.lastname: Richman
mesh_terms: D000787:Angina Pectoris / Q000175:diagnosis / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D009204:Myocardial Revascularization / Q000379:methods*; D018579:Patient Selection; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome