Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23.
We have identified human and mouse cDNAs encoding a novel ubiquitin-specific protease designated USP23. Both cDNAs encode a 62-kDa protein containing the highly conserved His and Cys domains characteristic of the C19 cysteine protease family of ubiquitin-specific processing proteases (UCH-2). Human tissue Northern blots revealed USP23 to be ubiquitously expressed, whereas USP12, its closest human paralogue, displayed a more restricted expression pattern. The human USP23 gene mapped to chromosome 1q22.
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Department of Molecular Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406, USA.
Southan
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019759:Carbon-Nitrogen Lyases; D002874:Chromosome Mapping; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017385:Sequence Homology; D043222:Ubiquitin Thiolesterase
C408875:USP21 protein, human; D043222:Ubiquitin Thiolesterase; D003546:Cysteine Endopeptidases; D019759:Carbon-Nitrogen Lyases