title: The influence of some prostaglandin analogous on the female rat ovary and uterine tube epithelium.
abstract: The synthetic analogous of the prostaglandins are utilized in the obstetrical and gynecological therapy for multiple purposes. 4 lots with 12 nonpregnant female rats were use: the Ist received 25 g/kg/day isopropyl ester PGF2; the IInd lot received 50 g/kg/day isopropyl ester PGF2; the IIIrd lot received 50 g/kg/day optic active cloprostenol; the IVth lot was the witness lot. The medication was intraperitoneally (i.p.) administrated in a unique daily dose. Prostaglandin F2 analogous at small doses (25 micrograms/kg/day) induce vasodilating effects on the ovary blood vessels and functional luteolysis rather than structural luteolysis. Both of the prostaglandins analogous at doses of 50 micrograms/kg/day present obvious vasodilating and luteolytic effects, although the intensity of the phenomenon is not the same, cloprostenol is more active, inducing a more obvious vasodilatation and luteolysis.
authors.affiliation: Faculty of Stomatologic Medicine, University of Medicine and Pharmacy Gr. T. Popa, Iaşi.
authors.forename: A
authors.initials: A
authors.lastname: Indrei
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
authors.forename: G
authors.initials: G
authors.lastname: Mihalache
authors.forename: M
authors.initials: M
authors.lastname: Grigore
authors.forename: F
authors.initials: F
authors.lastname: Cocu
authors.forename: L L
authors.initials: LL
authors.lastname: Indrei
mesh_terms: D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005187:Fallopian Tubes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D010053:Ovary / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D018709:Statistics, Nonparametric; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects
chemical_list: D003008:Cloprostenol; C041158:prostaglandin F2 isopropyl ester; D015237:Dinoprost