title: Chemolysis of urinary calculi.
abstract: Irrigant chemolysis was developed to collaborate with open surgery, removing the residual fragments. With the worldwide diffusion of the procedures performed by the endourologist in the early 1980s and the present availability of ESWL, however, direct irrigation of stones has a reduced field of influence even as an adjunctive measure. Urologists have applied economic analysis to their clinical practices, and the findings related to irrigant chemolysis made this technique an unusual procedure. The cost to the providers of medical care, the burden on the patient in terms of suffering and loss of productivity, and the amount of time required to liberate the patient even partially from the stones make irrigant chemolysis an inauspicious scenario. In this era of cost containment and decreasing length of stay, it is increasingly difficult to justify hospital admissions for this form of therapy. Being simultaneously more expensive and less effective than the existing alternatives, local chemolysis should be discarded, except for special situations, such as patients at high risk for any surgical procedure. Oral chemolysis preserves reduced indications, for example as an adjuvant to an endourologic operation or ESWL in special situations. As long as urinary stones continue to afflict humans, chemolysis is likely to retain a limited but important role in their management.
authors.affiliation: Department of Urology, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
authors.forename: N O
authors.initials: NO
authors.lastname: Bernardo
authors.forename: A D
authors.initials: AD
authors.lastname: Smith
mesh_terms: D002129:Calcium Oxalate / Q000032:analysis; D003553:Cystine / Q000032:analysis; D006801:Humans; D017616:Magnesium Compounds / Q000032:analysis; D010710:Phosphates / Q000032:analysis; D000069877:Struvite; D007507:Therapeutic Irrigation; D014527:Uric Acid / Q000032:analysis; D014545:Urinary Calculi / Q000737:chemistry / Q000188:drug therapy*
chemical_list: D017616:Magnesium Compounds; D010710:Phosphates; D002129:Calcium Oxalate; D014527:Uric Acid; D003553:Cystine; D000069877:Struvite