Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis.
OBJECTIVE
To clarify the differences in the clinical features between idiopathic interstitial pneumonia (IIP) and interstitial pneumonia associated with collagen vascular diseases (CVD-IP).


METHODS
Symptoms, radiographic findings, pulmonary function, blood chemistry data including autoantibody, and bronchoalveolar lavage fluid (BALF) findings were compared using multiple logistic regression analysis.


METHODS
The subjects were 44 patients clinically diagnosed with IIP and 33 patients with CVD-IP.


RESULTS
The clinical features related to IIP were as follows: male sex, advanced age, past history of hypertension, presence of cough, exertional dyspnea, digital clubbing, an increased level of gamma-globulin, decreased lung volume on chest X-ray, and typical type according to the criteria for IIP on chest X-ray. Increased levels of rheumatoid factor and total cell number in BALF were related to CVD-IP.


CONCLUSIONS
These findings are considered to be useful to differentiate IIP and CVD-IP.
Ishioka
S
S
Second Department of Internal Medicine, Hiroshima University School of Medicine.
Nakamura
K
K
Maeda
A
A
Hiyama
K
K
Watanabe
K
K
Maeda
H
H
Hayakawa
N
N
Yamakido
M
M
D000328:Adult; D000368:Aged; D018893:Bronchoalveolar Lavage; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002452:Cell Count; D003095:Collagen Diseases / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016015:Logistic Models; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013902:Radiography, Thoracic; D012217:Rheumatoid Factor / Q000097:blood; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D005719:gamma-Globulins / Q000378:metabolism
D005719:gamma-Globulins; D012217:Rheumatoid Factor