title: Short stereoselective route to gamma-CF3 allylic alcohols: rearrangements with creation of quaternary CF3-substituted carbons
abstract: A concise preparation of tetrasubstituted hindered functionalized CF3-olefins 2-7 from corresponding enol ether 3 is described. Geometrically pure gamma-CF3, gamma-alkyl allylic alcohols thus prepared could undergo Claisen-type rearrangements and provide, in good yields, carboxylic esters and amides containing a beta- quaternary CF3-substituted carbon.
authors.affiliation: BioCIS, UPRES A-8076, Centre d'Etudes Pharmaceutiques, Chatenay-Malabry, France.
authors.initials: D
authors.lastname: Bouvet
authors.initials: H
authors.lastname: Sdassi
authors.initials: M
authors.lastname: Ourevitch
authors.initials: D
authors.lastname: Bonnet-Delpon