Triterpenoids from Tripterygium wilfordii.
The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3beta,24-epoxy-2alpha-hydroxy-24R*-ethoxy-29-friedelanoic acid); (E) 3beta,24-epoxy-2-oxo-3alpha-hydroxy-29-friedelanoic acid; (F) 2beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production.
Duan
H
H
Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
Takaishi
Y
Y
Momota
H
H
Ohmoto
Y
Y
Taki
T
T
Jia
Y
Y
Li
D
D
D007166:Immunosuppressive Agents / Q000737:chemistry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry*
D007166:Immunosuppressive Agents; D014315:Triterpenes