title: Geographic distribution of a large mobile element that transfers ampicillin and vancomycin resistance between Enterococcus faecium strains.
abstract: In several clonally unrelated VanB-type vancomycin-resistant Enterococcus faecium strains, we demonstrated a common physical relationship between pbp5 and Tn5382 as well as common mutations within pbp5. The majority of these strains transferred vancomycin and ampicillin resistance to E. faecium in vitro, suggesting the dissemination of similar transferable pbp5-vanB-containing mobile elements throughout the United States.
authors.affiliation: Adult, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
authors.forename: J
authors.initials: J
authors.lastname: Hanrahan
authors.forename: C
authors.initials: C
authors.lastname: Hoyen
authors.forename: L B
authors.initials: LB
authors.lastname: Rice
mesh_terms: D000668:Ampicillin Resistance / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D004251:DNA Transposable Elements / Q000235:genetics*; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D012097:Repressor Proteins / Q000235:genetics; D014481:United States; D020713:Vancomycin Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; C080374:Psr protein, Enterococcus hirae; D012097:Repressor Proteins