title: [Ethanol inhibits platelet monoamine oxidase type B activity in patients with alcoholism].
abstract: The influence of 400 mM ethanol on the activity of monoamine oxidase type B (MAO-B) of blood platelets has been studied in vitro in 30 alcoholic patients and 30 healthy volunteers. Benzylamine was used as a substrate for MAO-B. MAO-B inhibition by ethanol was higher in alcoholics compared to healthy volunteers. The higher vulnerability of MAO-B of alcoholics inhibiting action to of ethanol may be one of the mechanisms underlying some symptoms of alcoholism.
authors.affiliation: Regional Scientific Center for Research in Addictions and Psychopharmacology, Pavlov St. Petersburg State Medical University. kru@lond.spb.su
authors.forename: E M
authors.initials: EM
authors.lastname: Krupitskiĭ
authors.forename: G F
authors.initials: GF
authors.lastname: Karandashova
authors.forename: V V
authors.initials: VV
authors.lastname: Vostrikov
authors.forename: N M
authors.initials: NM
authors.lastname: Lavrova
authors.forename: N I
authors.initials: NI
authors.lastname: Grinenko
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Slavina
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Grinenko
mesh_terms: D000437:Alcoholism / Q000097:blood*; D001792:Blood Platelets / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*
chemical_list: D000431:Ethanol; D008995:Monoamine Oxidase