A case of bilateral optic neuropathy in a patient on tacrolimus (FK506) therapy after liver transplantation.
OBJECTIVE
To report a case of bilateral optic neuropathy in a patient receiving tacrolimus (FK 506, Prograf; Fujisawa USA, Inc, Deerfield, Illinois) for immunosuppression after orthotropic liver transplantation.


METHODS
Case report. In a 58-year-old man receiving tacrolimus after orthotropic liver transplantation, serial neuro-ophthalmologic examinations and laboratory studies were performed.


RESULTS
The patient had episodic deterioration of vision in both eyes, with clinical features resembling ischemic optic neuropathies. Deterioration of vision occurred despite discontinuation of the tacrolimus.


CONCLUSIONS
Tacrolimus and other immunosuppressive agents may be associated with optic nerve toxicity.
Brazis
P W
PW
Department of Neurology, Mayo Clinic, Jacksonville, Florida 32224, USA.
Spivey
J R
JR
Bolling
J P
JP
Steers
J L
JL
D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000473:pathology; D016559:Tacrolimus / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity; D014794:Visual Fields
D007166:Immunosuppressive Agents; D016559:Tacrolimus