title: Triterpenoids from Tripterygium wilfordii.
abstract: The extract (T(II)) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3beta,24-epoxy-2alpha-hydroxy-24R*-ethoxy-29-friedelanoic acid); (E) 3beta,24-epoxy-2-oxo-3alpha-hydroxy-29-friedelanoic acid; (F) 2beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Duan
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: H
authors.initials: H
authors.lastname: Momota
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmoto
authors.forename: T
authors.initials: T
authors.lastname: Taki
authors.forename: Y
authors.initials: Y
authors.lastname: Jia
authors.forename: D
authors.initials: D
authors.lastname: Li
mesh_terms: D007166:Immunosuppressive Agents / Q000737:chemistry; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D007166:Immunosuppressive Agents; D014315:Triterpenes