AAA proteases: cellular machines for degrading membrane proteins.
AAA proteases are a conserved class of ATP-dependent proteases that mediate the degradation of membrane proteins in bacteria, mitochondria and chloroplasts. They combine proteolytic and chaperone-like activities and thus form a membrane-integrated quality-control system. Inactivation of AAA proteases causes severe defects in various organisms, including neurodegeneration in humans. Proteolysis by AAA proteases is modulated by another membrane-protein complex that is composed of prohibitins in eukaryotic cells and related proteins in bacteria.
Langer
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Adolf-Butenandt-Institut für Physiologische Chemie, Ludwig-Maximilians-Universität München, Goethestrasse 33, 80336 München, Germany. langer@bio.med.uni-muenchen.de
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D006868:Hydrolysis; D008565:Membrane Proteins / Q000378:metabolism*; D008666:Metalloendopeptidases / Q000378:metabolism*
D008565:Membrane Proteins; D008666:Metalloendopeptidases; C114583:m-AAA proteases; D000251:Adenosine Triphosphatases