Chiral discotic columnar germs of nucleosome core particles.
In concentrated solution and in the presence of high concentrations of monovalent cations, nucleosome core particles order into a discotic columnar mesophase. This phase is limited to finite-sized hexagonal germs that further divide into six coiled branches, following an iterative process. We show how the structure of the germs comes from the competition between hexagonal packing and chirality with a combination of dendritic facetting and double-twist configurations. Geometrical considerations lead us to suspect that the chirality of the eukaryotic chromosomes may originate from the same competition.
Livolant
F
F
Laboratoire de Physique des Solides, Université Paris Sud, 91405 Orsay Cedex, France. livolant@lps.u-psud.fr
Leforestier
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A
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002417:Cattle; D005614:Freeze Fracturing; D007091:Image Processing, Computer-Assisted; D008854:Microscopy, Electron; D008859:Microscopy, Polarization; D008954:Models, Biological; D009707:Nucleosomes / Q000737:chemistry / Q000648:ultrastructure*; D013237:Stereoisomerism
D009707:Nucleosomes