Relationship between the expression of caspase-3 and the clinical outcome of patients with non-small cell lung cancer.
This study examined whether a relationship exists between the expression of caspase-3 in 135 non-small cell lung carcinomas and clinical outcome. Immunohistochemistry and Western blot analyses were used to analyze the expression of caspase-3 in solid tumors and cell lines. A significant correlation was observed between the expression of caspase-3, survival and metastasis. Caspase-3 expression correlated with a lower incidence of lymph node involvement (p = 0.0007). The median survival was longer for patients with caspase-3 positive carcinomas than for those with caspase-3-negative tumors (41 vs 87 weeks, p = 0.038).
Koomägi
R
R
Department of Oncological Diagnostics and Therapy, German Cancer Research Center, Heidelberg, Germany.
Volm
M
M
D000328:Adult; D000368:Aged; D017209:Apoptosis; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D053148:Caspase 3; D020169:Caspases / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome; D014407:Tumor Cells, Cultured / Q000201:enzymology
D009363:Neoplasm Proteins; C505407:CASP3 protein, human; D053148:Caspase 3; D020169:Caspases