title: A study of lipid peroxide and alpha tocopherol in acute myocardial infarction.
abstract: Thirty patients of acute myocardial infarction proven by electrocardiography (ECG) and enzymes were included in the study. All of them received streptokinase. A single lead showing the largest ST elevation, a proportional value for the shift in ST segment > or = 0.5 was taken as criteria for reperfusion. ECG was recorded at 0 hour, 3 hours and 72 hours. At the start of streptokinase and 3 hours after, marker of free radical activity malondialdehyde (MDA) and antioxidant alpha tocopherol was measured. Mean value of serum alpha tocopherol level at start of streptokinase (t0) 10.03 +/- 2.5 micrograms/ml and at (t3) 3 hours after streptokinase was 8.60 +/- 2.6 micrograms/ml (P < 0.001) and mean value of serum lipid peroxidation level was 6.86 +/- 2.92 nanomol/ml at t(o) and at t3 value was 8.4 +/- 3.88 (P < 0.012) in successfully reperfused patients. In unsuccessful reperfusion group serum alpha tocopherol level at t(o) was 8.89 +/- 2.55 micrograms/ml and at t3 8.23 +/- 2.9 micrograms/ml (p > 0.05). Serum lipid peroxidation level in the same group at t0 was 6.53 +/- 2.26 nanomol/ml and at t3 was 6.29 +/- 2.27 nanomol/ml (p > 0.05). The increase in free radical marker MDA and decrease in one of the important antioxidant alpha tocopherol suggest that free radicals are increased after coronary vessels open up. As a result reperfused patients may be at risk of free radical mediated injury which may deny him the full benefit of reperfusion.
authors.affiliation: Dept of Medicine and Biochemistry, Maulana Azad Medical College.
authors.forename: M K
authors.initials: MK
authors.lastname: Daga
authors.forename: K
authors.initials: K
authors.lastname: Prabash
authors.forename: R
authors.initials: R
authors.lastname: Malhotra
authors.forename: T K
authors.initials: TK
authors.lastname: Mishra
mesh_terms: D000328:Adult; D000368:Aged; D004562:Electrocardiography; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*; D015425:Myocardial Reperfusion; D011446:Prospective Studies; D013300:Streptokinase / Q000627:therapeutic use; D014810:Vitamin E / Q000097:blood*
chemical_list: D005343:Fibrinolytic Agents; D014810:Vitamin E; D008315:Malondialdehyde; D013300:Streptokinase