title: Juvenile idiopathic inflammatory myopathies: the value of magnetic resonance imaging in the detection of muscle involvement.
abstract: BACKGROUND
  One of the major current challenges related to juvenile idiopathic inflammatory myopathy is the search for highly sensitive and specific non-invasive methods for diagnosis as well as for follow-up.
  
  
  OBJECTIVE
  The aim of our study was to describe typical magnetic resonance imaging findings and to investigate the usefulness of this method in detecting active muscle disease in juvenile dermatomyositis and juvenile systemic lupus erythematosus patients.
  
  
  METHODS
  Transverse study, blinded assessment.
  
  
  METHODS
  University referral unit (Pediatric Rheumatology section, Department of Pediatrics, Universidade Federal de São Paulo / Escola Paulista de Medicina).
  
  
  METHODS
  Thirteen patients (9 girls) with dermatomyositis, as well as 13 patients (12 girls) with juvenile systemic lupus erythematosus and 10 normal children (5 girls), were enrolled in the study.
  
  
  METHODS
  Qualitative and quantitative analyses of gluteus maximus, quadriceps, adductors and flexors were performed and evaluated by two radiologists, blinded to all clinical information. Spin-echo in T1, DP, T2 and IR was used in all MRI images.
  
  
  RESULTS
  The different muscle groups presented non-uniform involvement in the patients. The patients with dermatomyositis presented acute and chronic muscular alterations, while those with lupus presented only chronic myopathy, especially atrophy. In the dermatomyositis group, the major alterations were found in the gluteus and flexor regions (signal intensity and fat replacement). The signal intensity was increased in all acute myopathies.
  
  
  CONCLUSIONS
  The qualitative and quantitative resonance analyses are useful in detecting clinically active disease in patients with dermatomyositis.
authors.affiliation: Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: M O
authors.initials: MO
authors.lastname: Hilário
authors.forename: H
authors.initials: H
authors.lastname: Yamashita
authors.forename: D
authors.initials: D
authors.lastname: Lutti
authors.forename: C
authors.initials: C
authors.lastname: Len
authors.forename: M T
authors.initials: MT
authors.lastname: Terreri
authors.forename: H
authors.initials: H
authors.lastname: Lederman
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004796:Clinical Enzyme Tests; D003430:Cross-Sectional Studies; D003882:Dermatomyositis / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018908:Muscle Weakness / Q000175:diagnosis; D009132:Muscles / Q000473:pathology*; D016037:Single-Blind Method; D018709:Statistics, Nonparametric