Pharmacologic issues in the management of septic shock.
Despite our increased understanding of the biochemistry and physiology of sepsis, the treatment of septic shock remains a challenge. Initial management of septic shock entails urgent and emergent stabilization of the patient followed by broad-spectrum, empiric antibiotic therapy. After volume resuscitation, vasopressors or inotropic therapy or both may be necessary to restore perfusion. Adjunctive therapies and monitoring strategies may be helpful in preventing complications in the intensive care setting. Additional research and clinical trials are needed to identify supportive interventions that may affect the outcome of the septic patient.
Jindal
N
N
Department of Medicine, Rush Medical College, Chicago, Illinois, USA.
Hollenberg
S M
SM
Dellinger
R P
RP
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D006801:Humans; D020896:Hypovolemia / Q000188:drug therapy; D051437:Renal Insufficiency / Q000209:etiology; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D013152:Splanchnic Circulation / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D014662:Vasoconstrictor Agents; D004298:Dopamine