In vitro properties of red cells prepared from half-strength citrate CPD/RAS-2 (Erythro-sol) donations in PL-146 plastic.
Whole blood donations were collected into 0.5CPD anticoagulant in PL-146 plastic. This was shown to improve the stability of plasma FVIII levels when compared with CPD. RAS-2 was used as additive and this improved the in vitro properties of the red cells, such that post processing 2,3-DPG levels were maintained for 21 days and ATP levels were maintained for 28 days. Whether or not such improvements in red cell properties yield a benefit in clinical use remains to be established.
Hornsey
V S
VS
Scottish National Blood Transfusion Service, National Science Laboratory, Edinburgh, UK.
MacDonald
S
S
Drummond
O
O
Bethel
H
H
Walker
B
B
Prowse
C V
CV
D000925:Anticoagulants; D001672:Biocompatible Materials; D001782:Blood Donors; D001793:Blood Preservation / Q000295:instrumentation / Q000379:methods; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods; D002478:Cells, Cultured; D002951:Citrates; D004912:Erythrocytes / Q000166:cytology; D005169:Factor VIII; D005947:Glucose; D006801:Humans; D010969:Plastics
D000925:Anticoagulants; D001672:Biocompatible Materials; D002951:Citrates; D010969:Plastics; C007077:citrate phosphate dextrose; D005169:Factor VIII; D005947:Glucose