title: Long-term plasticity of postsynaptic GABAA-receptor function in the adult brain: insights from the oxytocin neurone.
abstract: The subunit switching of ligand-gated receptors is a potentially important mechanism through which synaptic plasticity can be achieved in the nervous system. Although established in an activity-dependent manner for neurotransmission that is mediated by excitatory amino acids, there is much less direct evidence for a role of subunit switching in long-term plasticity of GABAA receptors in the adult. We argue that the hypothalamic oxytocin neurones, which exhibit marked plasticity through each reproductive cycle, provide an excellent model of both presynaptic and postsynaptic long-term plasticity of GABA-mediated transmission in the mature nervous system. The postsynaptic plasticity involves GABAA-receptor-subunit switching in an activity-independent manner. It also has profound effects on the electrical behaviour of the oxytocin neurones and, thus, the neural control of pregnancy and lactation.
authors.affiliation: Dept of Neurophysiology of the Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands.
authors.forename: A B
authors.initials: AB
authors.lastname: Brussaard
authors.forename: A E
authors.initials: AE
authors.lastname: Herbison
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D006801:Humans; D007774:Lactation / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology*; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D010121:Oxytocin / Q000502:physiology*; D011247:Pregnancy; D011963:Receptors, GABA-A / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D011963:Receptors, GABA-A; D010121:Oxytocin