title: Malignant melanoma of the anorectal area. Report of two cases.
abstract: OBJECTIVE
  Primary anorectal melanoma is a very rare malignant tumor with no more than 300 cases reported in the literature.
  
  
  METHODS
  Two cases of anorectal melanoma are reported herein.
  
  
  RESULTS
  Both patients, aged 44 and 74 years, presented at the outpatient department with anal bleeding, one after being treated for 3 months with antihemorrhoidal drugs. The diagnosis was established with proctoscopy and biopsy, and a palliative abdominoperineal resection in the presence of lymph node metastases was performed followed by chemotherapy with vindesine. Although the procedures were not curative, both patients had an uneventful postoperative recovery, and lived 4 years and 21 months, respectively, without bleeding problems albeit with the inconvenience of a colostomy.
  
  
  CONCLUSIONS
  For the time being there is no convincing proof of the value of either types of proposed surgical management. We agree with those who believe that abdominal perineal resection has an advantage regarding the prognosis and quality of life.
authors.affiliation: First Department of Surgery, University of Athens, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Tsigris
authors.forename: E
authors.initials: E
authors.lastname: Pikoulis
authors.forename: J
authors.initials: J
authors.lastname: Bramis
authors.forename: A
authors.initials: A
authors.lastname: Leppäniemi
authors.forename: D
authors.initials: D
authors.lastname: Alexiou
authors.forename: E
authors.initials: E
authors.lastname: Bastounis
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006484:Hemorrhoids / Q000175:diagnosis; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000601:surgery*; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery*