title: Osteoinductive bone graft substitutes.
abstract: This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purified bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.
authors.affiliation: The Emory Spine Center, Emory University School of Medicine, Decatur, GA 30033, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Ludwig
authors.forename: J M
authors.initials: JM
authors.lastname: Kowalski
authors.forename: S D
authors.initials: SD
authors.lastname: Boden
mesh_terms: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D016025:Bone Transplantation; D002986:Clinical Trials as Topic; D005544:Forecasting; D006801:Humans; D016348:Osseointegration; D012106:Research; D013123:Spinal Fusion / Q000379:methods
chemical_list: D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes