title: The role of fas ligand in vivo as a cause and regulator of pathogenesis.
abstract: Recent studies have significantly advanced our understanding of the physiological and pathogenic functions of Fas and Fas ligand (FasL) in vivo. In particular, roles for Fas-FasL interactions both in the induction and regulation of organ-specific autoimmune diseases have been defined and in some cases the specific targets and effectors of these interactions have been identified. Understanding the dynamic role of the Fas-FasL pathway in autoimmunity will provide insight into how best to modulate this interaction to achieve therapeutic benefits.
authors.affiliation: Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA. ksabelko@pcg.wustl.edu.
authors.forename: K A
authors.initials: KA
authors.lastname: Sabelko-Downes
authors.forename: J H
authors.initials: JH
authors.lastname: Russell
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology*; D016923:Cell Death; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D018448:Models, Immunological; D019014:fas Receptor / Q000378:metabolism*
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D019014:fas Receptor