title: Cathepsin H expression distinguishes oncocytomas from renal cell carcinomas.
abstract: BACKGROUND
  Because the differential diagnosis of oncocytoma and renal cell carcinoma lacks specificity, new methods supporting correct diagnostic decisions are welcome.
  
  
  METHODS
  Sixteen cases of renal oncocytoma, and 16 sex-, age-, and stage- matched controls of renal cell carcinoma (T1-2N0M0) were studied. The minimum follow up exceeded ten years. There were no deaths due to neoplasm among oncocytomas, but 4 patient died with metastatic disease among cancer patients. Immunohistochemical staining for cathepsin H was quantified by 3 histoscores. The histoscores evaluated: 1) even cytoplasmic staining of neoplastic cells, 2) granular staining, or 3) total staining.
  
  
  RESULTS
  100% distinction was possible with the even cytoplasmic staining score. Total staining distinguished 87.5%, and granular staining 25% of neoplasms. CAM 5.2 cytokeratin, or vimentin distinguished 84.4% or 56.6% of these tumors, respectively.
  
  
  CONCLUSIONS
  Cathepsin H histoscore on even cytoplasmic immunostaining is an excellent method for the distinction of oncocytomas and renal cell carcinomas.
authors.affiliation: Department of Pathology, University of Turku, Finland. janne.castren.utu.fi
authors.forename: J P
authors.initials: JP
authors.lastname: Castrén
authors.forename: D E
authors.initials: DE
authors.lastname: Kamel
authors.forename: M J
authors.initials: MJ
authors.lastname: Nurmi
authors.forename: Y U
authors.initials: YU
authors.lastname: Collan
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D056655:Cathepsin H; D002403:Cathepsins / Q000032:analysis*; D003546:Cysteine Endopeptidases / Q000032:analysis*; D003937:Diagnosis, Differential; D004790:Enzyme Induction; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000032:analysis*; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D002403:Cathepsins; D003546:Cysteine Endopeptidases; C534126:CTSH protein, human; D056655:Cathepsin H