title: [Malignant non-Hodgkins B lymphoma related to Epstein-Barr virus and chronic natural killer lymphocytosis in a immunocompromised patient].
abstract: BACKGROUND
  Immunocompromised patients are at high risk of Epstein-Barr virus (EBV)-related lymphoproliferative disorders. The lymphoproliferation affects B, T, and natural killer (NK) cells.
  
  
  METHODS
  We report the case of a woman suffering from systemic lupus erythematous. She developed an opportunistic pneumonia while immunodepressed during long-term corticotherapy aimed at curing her auto-immune disease. Chronic lymphocytosis was also diagnosed at this time. Several months later, non-Hodgkin's lymphoma was diagnosed. Genomic amplification of the Epstein-Barr virus in the patient's blood and positive EBV latent membrane protein 1 on the lymph nodes provided evidence for a strong correlation between EBV reactivation and lymphoma.
  
  
  CONCLUSIONS
  Two distinct lymphoid diseases occurred during the immunosuppressive therapy for the auto-immune disease. PCR monitoring of Epstein-Barr virus allows for early screening of lymphoproliferative disorders in immunocompromised patients, leading to earlier and more efficient treatment.
authors.affiliation: Clinique des maladies infectieuses, CHU, Grenoble, France.
authors.forename: C
authors.initials: C
authors.lastname: Seinturier
authors.forename: M
authors.initials: M
authors.lastname: Péoch
authors.forename: P
authors.initials: P
authors.lastname: Morand
authors.forename: M C
authors.initials: MC
authors.lastname: Jacob
authors.forename: R
authors.initials: R
authors.lastname: Gressin
authors.forename: J P
authors.initials: JP
authors.lastname: Brion
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001706:Biopsy; D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007694:Killer Cells, Natural; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008218:Lymphocytosis / Q000150:complications* / Q000175:diagnosis; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000209:etiology* / Q000821:virology*; D012307:Risk Factors; D013256:Steroids
chemical_list: D000893:Anti-Inflammatory Agents; D013256:Steroids