title: An experimental approach to spinal fusion using sintered bovine bone in a pig model.
abstract: Sintered bovine bone is a biomaterial based on calcium phosphate, an organized crystal of bone mineral that possesses a natural trabecular structure. The authors considered whether sintered bovine bone can integrate with recipient bone and adjust to the strength of recipient bone for anterior spinal fusion in an animal model. Either autologous iliac bone or sintered bovine bone was implanted for a spinal body fusion. Some pigs underwent exposure of the spinal bodies without implantation. Based on radiographic evaluation, manual palpation, biomechanical testing, and histologic examination, spinal fusion with sintered bovine bone resulted in a composition and structure similar to that of the autograft (or of no implantation). The sintered bovine bone with its moderate strength tended to adjust to the bone stiffness of the host bone in the specimens as new bone grew.
authors.affiliation: Department of Orthopaedic Surgery, Wakayama Medical College, Wakayama City, Japan. minamide@wakayama-med.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Minamide
authors.forename: T
authors.initials: T
authors.lastname: Tamaki
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Hashizume
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D016025:Bone Transplantation / Q000379:methods*; D001842:Bone and Bones / Q000601:surgery; D002417:Cattle; D002516:Ceramics / Q000627:therapeutic use*; D004195:Disease Models, Animal; D011859:Radiography; D013123:Spinal Fusion / Q000379:methods*; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D013552:Swine