Bioactive compounds from Combretum erythrophyllum.
A methanol extract of Combretum erythrophyllum showed inhibitory bioactivities in a yeast-based microtiter assay for DNA-damaging agents. Bioassay-guided fractionation of this extract yielded two known bioactive compounds, combretastatin A-1 and (-)-combretastatin, and two new bioactive glucosides, combretastatin A-1 2'-beta-D-glucoside (1) and combretastatin B-1 2'-beta-D-glucoside (2). The structures of the new compounds were assigned by (1)H and (13)C NMR, DEPT, HMQC, and HMBC spectra.
Schwikkard
S
S
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0212, USA.
Zhou
B N
BN
Glass
T E
TE
Sharp
J L
JL
Mattern
M R
MR
Johnson
R K
RK
Kingston
D G
DG
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001632:Bibenzyls / Q000302:isolation & purification* / Q000633:toxicity; D002240:Carbohydrate Sequence; D004249:DNA Damage / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013019:South Africa; D013056:Spectrophotometry, Ultraviolet; D013267:Stilbenes / Q000302:isolation & purification* / Q000633:toxicity; D014407:Tumor Cells, Cultured; D014934:Wood
D000972:Antineoplastic Agents, Phytogenic; D001632:Bibenzyls; D006027:Glycosides; D010936:Plant Extracts; D013267:Stilbenes; C063690:combretastatin A-1; C040105:combretastatin