Squamocin and benzyl benzoate, acaricidal components of Uvaria pauci-ovulata bark extracts.
Annonaceae have been commonly described in traditional medicine as remedies against head lice and for their insecticidal properties. Acaricidal effects of Uvaria pauci-ovulata bark extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with those of benzyl benzoate used as standard acaricidal compound. A dichloromethane extract was the most effective with an EC50 = 0.028 g/m2 after a 24 h period as compared with benzyl benzoate (EC50 = 0.06 g/m2). Bioassay-guided fractionation of this extract led to the isolation of benzyl benzoate and squamocin; this latter compound also had acaricidal properties (EC50 = 0.6 g/m2). Moreover, squamocin was shown to potentiate the activity of benzyl benzoate using the fractional effective concentration (FEC) method.
Raynaud
S
S
Fourneau
C
C
Laurens
A
A
Hocquemiller
R
R
Loiseau
P
P
Bories
C
C
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D007306:Insecticides / Q000494:pharmacology*; D007783:Lactones / Q000494:pharmacology*; D008925:Mites / Q000187:drug effects; D008003:Phthiraptera / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
D001565:Benzoates; D005663:Furans; D007306:Insecticides; D007783:Lactones; D010936:Plant Extracts; C059660:squamocin; C006723:benzyl benzoate