title: Hypercalcemia due to talc granulomatosis.
abstract: Pulmonary disease due to talc, a group of hydrous magnesium silicates, is almost exclusively encountered after occupational exposure. One form of this rare disorder is talc granulomatosis. In varying degrees, hypercalcemia is typical of granulomatous disease but has not yet been reported in talcosis. We report the case of a former mold maker who presented with hypercalcemia. Laboratory findings indicated extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D. Pulmonary infiltrates prompted a lung biopsy that disclosed talc granulomatosis. We suggest that talc granulomatosis should be added to the list of granulomatous disorders capable of causing hypercalcemia due to increased extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D.
authors.affiliation: Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Woywodt
authors.forename: W
authors.initials: W
authors.lastname: Schneider
authors.forename: U
authors.initials: U
authors.lastname: Goebel
authors.forename: F C
authors.initials: FC
authors.lastname: Luft
mesh_terms: D000368:Aged; D001706:Biopsy; D002118:Calcium / Q000097:blood; D003937:Diagnosis, Differential; D015745:Granuloma, Foreign-Body / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000097:blood / Q000209:etiology*; D008171:Lung Diseases / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D013627:Talc / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D013627:Talc; D002118:Calcium