title: Model-based assessment of pressure and flow-dependent coronary responses following abrupt pressure drops.
abstract: The response of the coronary vasculature to an experimental manoeuvre of step-like decrease of the perfusion pressure has been investigated with a model. The coronary vasculature was simulated using a 'windkessel' scheme. Proximal resistance and compliance were assumed to be pressure-independent. The distal resistance, on the contrary, was controlled by a feed-back loop which accounts for the smooth muscle activation induced by the pressure variation. Three more parameters were introduced, and namely the smooth muscle activation time constant and the pressure-induced and flow-induced gains. The parameter values were assessed by comparing the model predicted coronary flow with the one actually measured in animals.
authors.affiliation: Dip. Neuroscienze (sez. Fisiologia), dell' Università di Torino, Torino, Italy. guiot@medfarm.unito.it
authors.forename: C
authors.initials: C
authors.lastname: Guiot
authors.forename: A
authors.initials: A
authors.lastname: Merletti
authors.forename: P
authors.initials: P
authors.lastname: Pagliaro
authors.forename: G
authors.initials: G
authors.lastname: Losano
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology; D008955:Models, Cardiovascular; D008962:Models, Theoretical; D009569:Nitric Oxide / Q000502:physiology; D014655:Vascular Resistance / Q000502:physiology; D014666:Vasomotor System / Q000503:physiopathology*
chemical_list: D009569:Nitric Oxide