title: Superior vena cava syndrome of malignant origin. Which surgical procedure for which diagnosis?
abstract: OBJECTIVE
  Since some malignancies causing superior vena cava syndrome (SVCS) are only sensitive to a specific treatment regimen, it is crucial to diagnose the underlying pathology in such cases. The aim of the present study was to review the surgical procedures used to establish the aetiology of SVCS of a malignant origin.
  
  
  METHODS
  This retrospective study was based on a series of 88 patients referred to surgeons for SVCS, for whom biological and/or endoscopic procedures had failed to establish the diagnosis. On the basis of the results of clinical examination, biological tests and CT-scan presentation, we performed 99 sampling procedures to obtain a diagnosis for all 88 patients. These procedures were the following: biopsy of peripheral adenopathy (n=11), CT-guided biopsy (CTGB; n=23), axial mediastinoscopy (MDS; n=23), anterior mediastinotomy (n=26), anterior mediastinoscopy (n=6), biopsy of the suprascapular mass (n=3), pericardioscopy (n=3), thoracoscopy (n=1), thoracotomy (n=2) and sternotomy (n=1).
  
  
  RESULTS
  Per-operative morbidity consisted of one case of massive venous bleeding during MDS requiring a salvage sternotomy to achieve hemostasis. The diagnoses finally established for the 88 patients were non-Hodgkin's lymphoma (NHL) for 36, small cell lung cancer for 25, non-small cell lung cancer for 17, Hodgkin's disease for five, thymoma for three, germ cell tumour for one and sarcoma for one. For the diagnosis of lung cancer, the sensitivities of CTGB and MDS were 85 and 100%, respectively. For the diagnosis of NHL, the sensitivity of anterior mediastinotomy was 95%.
  
  
  CONCLUSIONS
  The surgical diagnostic procedure, chosen on the basis of the clinical presentation and CT-scan, can be performed safely in the case of SVCS, with the same accuracy as in the absence of this syndrome. Among the patients referred to surgeons, NHL is the most frequent aetiology of SVCS, together with small cell lung cancer.
authors.affiliation: Division of Thoracic Surgery, Calmette Hospital, Lille University Hospital, 59037, Lille, France.
authors.forename: H
authors.initials: H
authors.lastname: Porte
authors.forename: D
authors.initials: D
authors.lastname: Metois
authors.forename: L
authors.initials: L
authors.lastname: Finzi
authors.forename: G
authors.initials: G
authors.lastname: Lebuffe
authors.forename: A
authors.initials: A
authors.lastname: Guidat
authors.forename: M
authors.initials: M
authors.lastname: Conti
authors.forename: A
authors.initials: A
authors.lastname: Wurtz
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013479:Superior Vena Cava Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D013906:Thoracoscopy; D013908:Thoracotomy / Q000379:methods*; D016896:Treatment Outcome