Baroreceptive and somatosensory convergent thalamic neurons project to the posterior insular cortex in the rat.
Connectivity between the rat posterior insula and the ventrobasal thalamus has been demonstrated anatomically. Neurons convergent for baroreceptor and nociceptive input have also been identified in the homologous anterior insula of the primate. Whether similar convergent cells exist in the ventrobasal thalamus was investigated in 30 urethane anesthetized male Sprague--Dawley rats. Six classes of cells were identified in the right ventrobasal thalamus: (a) 83/159 (52%) baroreceptive and nociceptive convergent units; (b) 2/159 (1%) convergent cells responding to baroreceptor activation and light touch; (c) 44/159 (28%) purely nociceptive units; (d)10/159 (6%) purely baroreceptive units; (e) 1/159 (0.6%) cells responding to brush alone and (f) 19/159 (12%) unresponsive units. Of the viscerosomatic convergent cells, 66/85 (78%) were situated in the ventroposterolateral nucleus (VPL), 6/85 (7%) in the ventroposterolateral parvicellular nucleus (VPLpc), and 13/85 (15%) in the ventroposteromedial nucleus (VPM). Fifteen right ventrobasal thalamic units were antidromically activated and 34 units orthodromically activated by right posterior insular microstimulation. Cobalt injection into the right ventrobasal thalamus blocked the right insular response to baroreceptor activation by >70%. These data indicate: (a) baroreceptive and somatosensory nociceptive convergent units exist in the ventrobasal thalamus; (b) thalamic convergent neurons project directly to the ipsilateral posterior insula and receive reciprocal insulothalamic projections; and (c) a significant proportion of baroreceptor input relays to the posterior insula through the ipsilateral ventrobasal thalamus.
Zhang
Z H
ZH
Laboratory of Neurocardiology, Cerebrovascular Division, Department of Neurology, Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Meyer 5-185, 600 North Wolfe St, Baltimore, MD 21287-7585, USA.
Oppenheimer
S M
SM
D000818:Animals; D008297:Male; D009434:Neural Pathways / Q000033:anatomy & histology; D009474:Neurons / Q000502:physiology; D009619:Nociceptors / Q000502:physiology*; D011311:Pressoreceptors / Q000033:anatomy & histology / Q000502:physiology*; D016548:Prosencephalon / Q000033:anatomy & histology / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*; D013788:Thalamus / Q000033:anatomy & histology / Q000502:physiology*