title: Synthesis and properties of novel antisense oligonucleotides bearing an anthraquinone moiety at an internucleotide linkage.
abstract: Antisense oligonucleotides bearing an anthraquinone moiety at an internucleotide linkage were synthesized utilizing the stereoisomers of anthraquinone incorporated T-C dimer phosphoramidite derivatives. Some physicochemical properties of the anthraquinon bearing oligomers were investigated.
authors.affiliation: Chemistry Lab., Yamasa Corporation, Choshi, Chiba, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyashita
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Shinozuka
mesh_terms: D000880:Anthraquinones; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D007202:Indicators and Reagents; D019906:Nuclear Magnetic Resonance, Biomolecular; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D020319:Oligodeoxyribonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D013873:Thionucleotides
chemical_list: D000880:Anthraquinones; D007202:Indicators and Reagents; D020319:Oligodeoxyribonucleotides, Antisense; D013873:Thionucleotides; D012313:RNA; D004247:DNA