title: Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3.
abstract: In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1beta by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.
authors.affiliation: Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844-3052, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Wesson
authors.forename: J
authors.initials: J
authors.lastname: Deringer
authors.forename: L E
authors.initials: LE
authors.lastname: Liou
authors.forename: K W
authors.initials: KW
authors.lastname: Bayles
authors.forename: G A
authors.initials: GA
authors.lastname: Bohach
authors.forename: W R
authors.initials: WR
authors.lastname: Trumble
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases / Q000276:immunology*; D002417:Cattle; D002478:Cells, Cultured; D016207:Cytokines / Q000235:genetics; D004705:Endocytosis / Q000276:immunology; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000276:immunology*
chemical_list: D016207:Cytokines; D053148:Caspase 3; D053181:Caspase 8; D053453:Caspase 9; D020169:Caspases