Neurological crisis mimicking acute pancreatitis in tyrosinemia type I.
Hereditary tyrosinemia results from an inborn error in the final step of tyrosine metabolism. Neurological manifestations have been reported in nearly half of patients during illness to have characteristics of altered consciousness, weakness, anorexia, vomiting, and pain in the extremities and abdomen. His physical findings and laboratory results pointed out acute pancreatitis. There have been some reports of acute and chronic pancreatitis in patients with metabolic diseases; however, this is the first case with tyrosinemia type I who exhibited clinical and biochemical findings of acute pancreatitis during neurological crisis. The presented case suggests the possibility that the pancreas is affected in neurological crisis. The determination of amylase concentration both in serum and urine samples of further cases will clarity the association between pancreatitis and neurological crisis.
Kalkanoğlu
H S
HS
Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
Coşkun
T
T
D000208:Acute Disease; D000293:Adolescent; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000175:diagnosis*; D020176:Tyrosinemias / Q000175:diagnosis*