title: Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones.
abstract: Several substituted 2- and 4-hydroxyacetophenones are linked to Wang resin via a modified Mitsunobu protocol. These resin-bound acetophenones are condensed with aromatic aldehydes, and the resulting chalcones 5 are used for the synthesis of 2-dialkylamino- (9a-d) and 2-alkylamino-4,6-diarylpyridines (11a-f), and 2-alkyl-4,6-diaryl- (14a) and 2,4,6-triarylpyrimidines (14b,c) in a manner suitable for combinatorial applications.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville 32611-7200, USA.
authors.forename: A R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: L
authors.initials: L
authors.lastname: Serdyuk
authors.forename: C
authors.initials: C
authors.lastname: Chassaing
authors.forename: D
authors.initials: D
authors.lastname: Toader
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Forood
authors.forename: B
authors.initials: B
authors.lastname: Flatt
authors.forename: C
authors.initials: C
authors.lastname: Sun
authors.forename: K
authors.initials: K
authors.lastname: Vo
mesh_terms: D000098:Acetophenones; D000447:Aldehydes / Q000138:chemical synthesis; D002599:Chalcone / Q000737:chemistry*; D007202:Indicators and Reagents; D011725:Pyridines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*; D012116:Resins, Plant
chemical_list: D000098:Acetophenones; D000447:Aldehydes; D007202:Indicators and Reagents; D011725:Pyridines; D011743:Pyrimidines; D012116:Resins, Plant; D002599:Chalcone