title: Site-specific serine incorporation by Lif and Epr into positions 3 and 5 of the Staphylococcal peptidoglycan interpeptide bridge.
abstract: The FemAB-like factors Lif and Epr confer resistance to glycylglycine endopeptidases lysostaphin and Ale-1, respectively, by incorporating serine residues into the staphylococcal peptidoglycan interpeptide bridges specifically at positions 3 and 5. This required the presence of FemA and/or FemB, in contrast to earlier postulations.
authors.affiliation: Bayer AG, PH Research Antiinfectives I, D-42096 Wuppertal, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Ehlert
authors.forename: M
authors.initials: M
authors.lastname: Tschierske
authors.forename: C
authors.initials: C
authors.lastname: Mori
authors.forename: W
authors.initials: W
authors.lastname: Schröder
authors.forename: B
authors.initials: B
authors.lastname: Berger-Bächi
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D016297:Mutagenesis, Site-Directed; D010455:Peptides / Q000378:metabolism; D010457:Peptidoglycan / Q000378:metabolism*; D012694:Serine / Q000235:genetics / Q000378:metabolism*; D013210:Staphylococcus / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C107107:Epr protein, Staphylococcus capitis; C096686:FemA protein, Bacteria; C102928:FemB protein, Staphylococcus epidermidis; D010455:Peptides; D010457:Peptidoglycan; D012694:Serine