title: [The evaluation of noninvasive samples for detecting anti-cytomegalovirus IgG antibodies].
abstract: Patients admitted in dialysis centers are at greatest risk to achieve blood-borne infections. One of the most frequent is the cytomegalovirus infection, acquired from transfused blood products. The aim of our study was to determine the prevalence of IgG anti-CMV in patients on dialysis at the "C. I. Parhon" Hospital from Iaşi (Romania). In addition, the role of non-invasive samples (saliva and capillary blood) for such epidemiological studies was determined. ELISA Wellcome anti-CMV IgG was used for identification of specific antibodies in serum, capillary blood, saliva. The prevalence of anti-CMV IgG in the group of study was higher than that established in general populations and 79.06% saliva specimens and 93.76% of capillary blood samples were positive. To establish the specificity, sensitivity and predictive values of Wellcome anti-CMV when non-invasive samples are used, we compared the results obtained by testing saliva and capillary blood to those obtained by testing serum. We may conclude that the non-invasive samples are useful for CMV-infection surveillance in risk groups.
authors.affiliation: Disciplina de Microbiologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: D
authors.initials: D
authors.lastname: Bosnea
authors.forename: C
authors.initials: C
authors.lastname: Apetrei
authors.forename: A
authors.initials: A
authors.lastname: Covic
authors.forename: M
authors.initials: M
authors.lastname: Covic
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D002196:Capillaries; D003587:Cytomegalovirus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D006435:Renal Dialysis; D012463:Saliva / Q000276:immunology*; D012680:Sensitivity and Specificity; D014680:Veins
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G