title: Solitary fibrous tumour of the oral cavity: clinicopathological and immunohistochemical characterization of three cases.
abstract: Solitary fibrous tumour (SFT) is an uncommon mesenchymal neoplasm rarely located in the oral cavity. To characterize further oral SFT, we describe three new cases. Each tumour originated in the buccal mucosa of a middle-aged/elderly patient. Histological examination showed well-circumscribed tumours with densely cellular areas alternating with hypocellular areas in a variedly collagenous, vascular stroma. Mast cells were abundant. The spindle-shaped, neoplastic cells immunostained strongly for CD34 antigen and vimentin and weakly for bcl-2, but not for epithelial cell markers, alpha-smooth muscle actin, or neurofilament or S-100 proteins. Compatible with the virtual absence of mitoses and of marked nuclear atypia, the overall frequency of proliferating cells expressing Ki-67 was low. The expression of CD34 was useful in the differential diagnosis. The consistent location in the cheek and expansion of one tumour after local trauma does not preclude a traumatic element in the development of oral SFT.
authors.affiliation: Department of Oral Pathology, Institute of Dentistry, University of Helsinki, Finland.
authors.forename: P L
authors.initials: PL
authors.lastname: Lukinmaa
authors.forename: J
authors.initials: J
authors.lastname: Hietanen
authors.forename: G
authors.initials: G
authors.lastname: Warfvinge
authors.forename: J
authors.initials: J
authors.lastname: Sane
authors.forename: S
authors.initials: S
authors.lastname: Tuominen
authors.forename: V
authors.initials: V
authors.lastname: Henriksson
authors.forename: A
authors.initials: A
authors.lastname: Larsson
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D001808:Blood Vessels / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D003094:Collagen; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008407:Mast Cells / Q000473:pathology; D008875:Middle Aged; D008938:Mitosis; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D018218:Neoplasms, Fibrous Tissue / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D014746:Vimentin; D003094:Collagen