title: Clinical profile and management of PDA in neonates.
abstract: Patent ductus arteriosus (PDA) is recognised more often with increasing survival of preterm babies. The pharmacological closure of ductus by indomethacin has changed the management of PDA. Twenty neonates admitted over a period of 21 months to Neonatal Intensive Care Unit (NICU) of M.S. Ramaiah Medical College hospital, Bangalore, who were diagnosed to have PDA, were analyzed. The objectives of this retrospective analysis were to study the clinical profile, the efficacy of oral indomethacin and the outcome of PDA. 2-D and Doppler echocardiaography were used to confirm the clinically suspected PDA. These neonates were treated with 3 doses of oral indomethacin (0.2-0.25 mg/kg/dose 12 hourly) along with fluid restriction and oxygen. Echocardiography was repeated to demonstrate the closure of PDA. The incidence of PDA was 2.3% of total NICU admissions. Seventy percent of this cohort were < 32 weeks of gestation, 55% had birth weight of < 1500 gms. Seventy percent (14) neonates had onset of PDA after 48 hrs of life. 81.25% of neonates responded to indomethacin and overall survival rate in treated group was 67%. Drug related complications were noted in 2 newborns. This study illustrates the utility of echocardiography in diagnosing and monitoring PDA in preterm and low birth weight babies with high index of suspicion of this common congenital heart disease. Pharmacological intervention with indomethacin is rewarding with acceptable results.
authors.affiliation: Department of Pediatrics, M.S. Ramaiah Medical College, Bangalore.
authors.forename: C C
authors.initials: CC
authors.lastname: Shanthala
authors.forename: P P
authors.initials: PP
authors.lastname: Maiya
authors.forename: D
authors.initials: D
authors.lastname: Vishwanath
authors.forename: N
authors.initials: N
authors.lastname: Banakappa
authors.forename: P M
authors.initials: PM
authors.lastname: Swamy
authors.forename: N
authors.initials: N
authors.lastname: Desai
authors.lastname: Ravikishore
authors.forename: K H
authors.initials: KH
authors.lastname: Srinivas
mesh_terms: D000284:Administration, Oral; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D007194:India; D007213:Indomethacin / Q000008:administration & dosage*; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality; D007363:Intensive Care Units, Neonatal; D008297:Male; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
chemical_list: D002317:Cardiovascular Agents; D007213:Indomethacin