[Three pediatric cases of erythroleukemia: review of the literature on prognostic factors].
We encountered 3 patients with erythroleukemia who showed differing outcomes. The first patient was an 11-year-old girl who was treated with an ANLL 91 national protocol followed by bone marrow transplantation from an HLA-identical brother. She is still in complete remission after 6 years. The second patient was a 15-year-old girl. Treatment with low dose Ara-C was effective. She experienced a relapse once, but achieved her second remission with low dose-Ara-C plus vitamin D. Up to the present, she has maintained remission for 5 years. The third patient was a 1-month-old girl who initially presented with an increase of proerythroblasts with infiltration to the liver. Although her response to Ara-C and etoposide was favorable, she died of a generalized fungal infection in the leukopenic phase. Chromosomal analyses of bone marrow cells were normal for patients 1 and 2, but patient 3 had an abnormal complex karyotype. We think the prognosis for erythroleukemia in childhood is not necessarily poor in all cases. Appropriate treatment should be based on the patient's age, the proportion of proerythroblasts, and the presence of chromosomal abnormalities.
Kubota
M
M
Department of Pediatrics, Faculty of Medicine, Kyoto University.
Hamahata
K
K
Watanabe
K
K
Lin
Y W
YW
Koishi
S
S
Usami
I
I
Nakahata
T
T
Akiyama
Y
Y
D000293:Adolescent; D005260:Female; D006801:Humans; D007223:Infant; D004915:Leukemia, Erythroblastic, Acute / Q000401:mortality / Q000628:therapy*; D008297:Male; D011379:Prognosis; D016896:Treatment Outcome