title: Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line.
abstract: Two flavonoids, quercetin-3-O-beta-D-glucopyranoside (1) and quercetin-3,7-di-O-beta-D-glucopyranoside (2), were isolated from the leaves of Morus alba (Moraceae). These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2 x 10(-4) M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens. These flavonoids exhibited significant free radical scavenging effects on 1,1-diphenyl-2-picryl-hydrazyl radical.
authors.affiliation: Graduate School of East-West Medical Science, Kyunghee University, Seoul, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: J J
authors.initials: JJ
authors.lastname: Gao
authors.forename: H K
authors.initials: HK
authors.lastname: Kang
mesh_terms: D002454:Cell Differentiation / Q000187:drug effects*; D002469:Cell Separation; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D018515:Plant Leaves / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D005419:Flavonoids