title: The prevalence of serum GB virus C/hepatitis G virus RNA and anti-E2 in Japanese children without a history of blood transfusion.
abstract: The prevalence of serum GB virus C (GBV-C)/Hepatitis G virus (HGV) RNA and anti-E2 was investigated in Japanese children younger than 16 years of age without a history of blood transfusion and the family members of serum GBV-C/HGV RNA-positive children. The prevalences of serum GBV-C/HGV RNA and anti-E2 were 0.5% (5/1000) and 0% (0/330), respectively. Viral RNA was also detected in the mothers of all five GBV-C/HGV RNA-positive children and in two of their siblings. Sequence determinations indicated the likelihood of mother-to-infant transmission in all cases. The presence of the virus persisted for at least 10-18 months in all 5 children, without any appearance of anti-E2.
authors.affiliation: Department of Pediatrics, Nagoya City University Medical School, Japan. fmiz@med.nagoya-cu.ac.jp
authors.forename: F
authors.initials: F
authors.lastname: Mizutani
authors.forename: K
authors.initials: K
authors.lastname: Sugiyama
authors.forename: K
authors.initials: K
authors.lastname: Goto
authors.forename: T
authors.initials: T
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Terabe
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
mesh_terms: D000293:Adolescent; D001483:Base Sequence; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018067:Flaviviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006508:Hepatitis Antibodies / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D007564:Japan / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D010375:Pedigree; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood*; D016036:Seroepidemiologic Studies
chemical_list: D006508:Hepatitis Antibodies; D012367:RNA, Viral