Neuro-psychological discorders and renal cell carcinoma: a case report and a psychological study of urological cancer patients.
Several pathways for immunodepression induced by stress and injury have been speculated, with precise analysis regarding out correlations between sympathetic nerve system and immunodepressive cytokines. Here, we show an interesting case and a clinical study of psychological disorders of urological advanced cancer patients. In the case report, a male renal-cell cancer patient whose disease disappeared following interferon therapy is presented whose disease relapsed five years after therapy and eight months after a traffic injury. Careful observation of the history suggests that severe pain could destruct patient's own anti-cancer mechanisms. In the clinical study on psychological disorders of the 131 patients, a higher rate (28%) of disorders was recognised in renal-cell cancer patients than in other cancer patients. Serum CRP values of the renal-cell cancer patients with the disorders was significantly higher than those of the same cancer patients without the disorders. A complicated inter-relationship between the central nercous system, various external forces, the cancer itself and the immune system may exist and have an influence on the efficacy of biotherapy.
Kato
M
M
Department of Urology, Satitama Medical School, Japan.
Miyakawa
M
M
Okada
K
K
D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000523:psychology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000473:pathology*; D012008:Recurrence; D013736:Testicular Neoplasms / Q000473:pathology / Q000523:psychology*