The in vivo sensitivity of Plasmodium falciparum to chloroquine in the Red River basin, Yunnan, China.
The sensitivity of Plasmodium falciparum to chloroquine in vivo was examined out in a small town in the Red River basin from 1995 to 1996. forty cases were recruited into the present study, 32 cases were completely followed-up. The results of the in vivo study revealed that only 3 (9%) cases were sensitive to chloroquine, 29 (90.6%) showed resistance to chloroquine, among whom 7 cases (22%) showed resistance at RI, 12 cases (38%) at RII, and 10 cases (31%) at RIII. It is suggested that P. falciparum endemic areas should stop using chloroquine and other 4-aminoquinolines in the Red River basin now. Qinhaosu and pyronaridine were recommended to use as the first line antimalarial drugs of P. falciparum infection in the basin.
Hong-Ping
G
G
Honghe Prefecture Health and Anti-epidemic Station, Geju, Yunnan, PR China.
Yao
Z
Z
Qian
D
D
Jin-Hua
Y
Y
Kai-Xun
J
J
Min
Z
Z
D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000469:parasitology; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects*; D016896:Treatment Outcome
D000962:Antimalarials; D002738:Chloroquine