[The influence of antenatal TRH and glucocorticoids therapy for survival rate of extremely low birth infant].
Respiratory distress syndrome (RDS) as a consequence of lung immaturity remains a major cause of perinatal morbidity and mortality. TRH used with glucocorticoids shows synergistic influence on surfactant synthesis and morphological lung maturation in preterm born infants. The purpose of this study was to examine the influence of antenatal TRH + glucocorticoids treatment on survival rate of extremely low birth infants (less than 1000 g). We evaluated 94 premature neonates born between 1993 and 1997 at the Department of Obstetrics and Perinatology of University School of Medicine in Lublin. Better survival rate of extremely low birth infants was observed in the TRH + steroids group then in only steroids one. The ratio of RDS was similar in both groups. Further investigations to determine the safety and efficacy of antenatal TRH therapy are needed.
Leszczyńska-Gorzelak
B
B
Kliniki Połoznictwa i Perinatologii, AM w Lublinie.
Laskowska
M
M
Poniedziałek-Czajkowska
E
E
Oleszczuk
J
J
D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D011295:Prenatal Care; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy* / Q000401:mortality*; D012189:Retrospective Studies; D013501:Surface-Active Agents / Q000378:metabolism; D015996:Survival Rate; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology* / Q000627:therapeutic use*
D005938:Glucocorticoids; D013501:Surface-Active Agents; D013973:Thyrotropin-Releasing Hormone