5-(4-Hydroxyphenethenyl)-4,7-dimethoxycoumarin, a new constituent of Monotes engleri.
A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.
Seo
E K
EK
Chai
H B
HB
Chagwedera
T E
TE
Farnsworth
N R
NR
Cordell
G A
GA
Pezzuto
J M
JM
Kinghorn
A D
AD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
C407863:5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin; D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins