title: Recognition of flexible peptides in water by transition metal complexes.
abstract: This paper describes the design, synthesis, and evaluation of transition metal complexes capable of recognizing flexible histidine-containing peptides in aqueous medium (25 mM HEPES buffer, pH = 7.0, 25 degrees C). When the pattern of metal ions on a complex matches with the pattern of histidine moieties on the peptide, strong interaction (K = 1.2 x 10(6) M-1) can be achieved. The complex was highly selective (> 200:1) in discriminating similar flexible peptides differing only by one glycine unit.
authors.affiliation: Department of Chemistry, North Dakota State University, Fargo 58105, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sun
authors.forename: M
authors.initials: M
authors.lastname: Abul Fazal
authors.forename: B C
authors.initials: BC
authors.lastname: Roy
authors.forename: S
authors.initials: S
authors.lastname: Mallik
mesh_terms: D005998:Glycine / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D008670:Metals; D010455:Peptides; D014867:Water; D006639:Histidine; D005998:Glycine