[Common properties of pharmacological agonists and antagonists of surface membrane receptors].
Using experimental transcription model in vitro, and method of electron-topological calculations the elements of pharmacological and structural community have been found in the groups of physiologically active compounds (PAC), blocking and activating external cellular receptors. This finding confirms the necessity of subdivision special groups of bio-substrates blockators and activators for hierarchical classification, of PAC.
Luĭk
A I
AI
Institute of Bioorganic and Petroleum Chemistry of the National, Academy of Sciences of Ukraine, Kiev, Ukraine.
Prokopenko
V V
VV
Tanchuk
V Iu
VIu
Kholodovich
V V
VV
Semeniuta
I V
IV
D000818:Animals; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000819:agonists* / Q000037:antagonists & inhibitors* / Q000502:physiology; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic
D008024:Ligands; D011956:Receptors, Cell Surface