A convenient extension of the Wessely-Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro.
A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine via a seven step sequence. The synthesis of their 6-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely-Moser rearrangement. These compounds were found to be efficient neuroprotective agents in vitro.
Larget
R
R
Laboratoire de Chimie, Analytique et Electrochimie, UMR 8638 CNRS-Université René Descartes, Faculté des Sciences Pharmaceutiques et Biologiques, Paris, France.
Lockhart
B
B
Renard
P
P
Largeron
M
M
D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D005419:Flavonoids; D018696:Neuroprotective Agents