Pharmacokinetics of ketoprofen syrup in small children.
Ketoprofen is a nonsteroidal anti-inflammatory drug with analgesic, anti-inflammatory, and antipyretic properties. Its pharmacokinetics has not been determined in small children. The objective here was to determine the pharmacokinetics of ketoprofen syrup, 0.5 mg/kg, in two groups of 10 children. Group 1 was from ages 6 months up to 2 years (7/10 younger than 1 year), and Group 2 was from ages 2 to 7 years. Venous blood samples were collected before drug administration and 0.5, 1, 2, 4, 6, 8, and 12 hours after. A validated HPLC method was used to determine plasma levels of ketoprofen. The lower limit of quantification was 0.02 microgram/ml of plasma. Ketoprofen syrup was absorbed rapidly, the plasma level reaching its maximum at 0.5 hours, with C0.5 hours = 3 micrograms/ml. The pharmacokinetics was similar between the two groups of children. The elimination half-life, 2.0 hours in Group 1 or 1.9 hours in Group 2, was similar to that reported in adults.
Kokki
H
H
Department of Anesthesiology and Intensive Care, Kuopio University Hospital, Finland.
Le Liboux
A
A
Jekunen
A
A
Montay
G
G
Heikkinen
M
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007660:Ketoprofen / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010592:Pharmaceutic Aids; D011446:Prospective Studies; D014018:Tissue Distribution
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010592:Pharmaceutic Aids; D007660:Ketoprofen