Effect of intra-aortic magnesium on renal function during and after abdominal aortic surgery: a pilot study.
BACKGROUND
Infrarenal aortic cross-clamping causes renal vasoconstriction. Magnesium may protect against renal deterioration through its vasodilatory properties.


METHODS
Thirty patients with normal preoperative renal function undergoing infrarenal aortic cross-clamping for elective aortic surgery received magnesium (4 mmol) or saline into the aorta immediately after aortic cross-clamping and again just before unclamping in a double-blind fashion. Pulmonary artery occlusion pressure was maintained 215 mmHg. Five patients with magnesium were excluded due to need for intravenous nitroglycerine because of myocardial ischaemia during the study.


RESULTS
Postoperative creatinine clearance remained unchanged in both groups. Urinary N-acetyl-beta-D-glucosaminidase excretion increased before and decreased after aortic cross-clamping in both groups. The concentrations of glutathione peroxidase in serum were identical between the two groups.


CONCLUSIONS
These data indicate that intra-aortic magnesium had no effect on renal function during or after aortic cross-clamping.
Bäcklund
M
M
Department of Anaesthesia, Helsinki University Central Hospital, Finland.
Pere
P
P
Lepäntalo
M
M
Lehtola
A
A
Lindgren
L
L
D000118:Acetylglucosaminidase / Q000652:urine; D001012:Aorta, Abdominal / Q000601:surgery*; D003404:Creatinine / Q000652:urine; D004311:Double-Blind Method; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014508:Urea / Q000652:urine; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
D014665:Vasodilator Agents; D014508:Urea; D003404:Creatinine; D005979:Glutathione Peroxidase; D000118:Acetylglucosaminidase; D008274:Magnesium