title: Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue.
abstract: New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors.
authors.affiliation: Laboratoire de Chimie Biomoléculaire et Interactions Biologiques associé au C.N.R.S., Université Montpellier 1, Faculté de Pharmacie, France.
authors.forename: A
authors.initials: A
authors.lastname: Vidal
authors.forename: T
authors.initials: T
authors.lastname: Durand
authors.forename: J P
authors.initials: JP
authors.lastname: Vidal
authors.forename: J C
authors.initials: JC
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Ravasi
authors.forename: S
authors.initials: S
authors.lastname: Zarini
authors.forename: A
authors.initials: A
authors.lastname: Sala
mesh_terms: D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D017572:Leukotriene A4 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D017997:Leukotriene C4 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000378:metabolism
chemical_list: C412032:19-((2-azido-5-iodo)benzoyloxy)leukotriene A(4); C412033:19-((2-azido-5-trimethylstannyl)benzoyloxy)leukotriene A(4); D017572:Leukotriene A4; D009947:Organotin Compounds; D017997:Leukotriene C4; D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase