title: [The effect of a photo-developing solution on respiratory and cardiac activities in rats when orally administered].
abstract: The development of cinema art brought about the increase in the number of laboratories which prepare photosensitive materials. In case of laboratories not complying with rules regarding the preparation and handling of the solutions for processing photos, these solutions can penetrate in the organism trough the skin and be accidentally digested. The goal of the experiment is to study the effects of developing solution for white/black Azomureş photographic paper on respiratory and cardiac activity of the Wistar rat (weight = 180-200 g) through oral administration. Three experimental groups (lots) of animals were formed (8 animals/group). The control group was given 1 ml of distilled water; the first (I) group was given 1 ml of 1/10 diluted photo-processing solution and the second (II) group was given 1 ml of the same solution, but 1/4 diluted. The administration of it was made in a single dose with a gastric drill. The respiratory and cardiac (ECG) frequencies were monitored during a 4 hours period, from the onset of administration. When 1/10 diluted developing solution was administrated a decrease in the respiratory frequency was recorded after one hour, but the effect vanished at the end of the experiment (4 hours). Fifteen minutes after 1/4 diluted solution was administered, a decrease in respiratory frequency per minute was determined, this result also disappeared at the end of 4 hours. However, these differences failed to reach significance (p = 0, 54). The effect of developing solution on cardiac activity shows a decrease of cardiac frequency in both experimental (I, II) groups. However, there is a difference in the effect of the diluted solution on the rats. The 1/10 diluted solution decrease the cardiac frequency over an approximate period of 1 hour and a half, but the 1/4 diluted solution showed a decrease in cardiac frequency up until the end of the ECG reading.
authors.affiliation: Disciplina de Igienă, Facultatea de Medicină, Universitatea de Medicină şi Farmacie, Târgu Mureş.
authors.forename: A
authors.initials: A
authors.lastname: Peti
authors.forename: J
authors.initials: J
authors.lastname: Domahidi
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004562:Electrocardiography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*; D012996:Solutions; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D012996:Solutions