title: Significance of pretreatment serum hemoglobin and survival in epithelial ovarian cancer.
abstract: Tumor anemia is common in patients with malignant tumors and it was repeatedly demonstrated to be associated with impaired prognosis in patients with malignant tumors. We conducted a retrospective analysis based on 553 patients with histologically proven epithelial ovarian cancer. Blood hemoglobin levels were determined before surgery and patients with values <12 g/dl were considered anemic. Data analysis included univariate and multiple Cox models. Tumor anemia was present in 143 (25.9%) patients before surgery. Tumor anemia was present in 143 (25.9%) patients before surgery. In a multivariate Cox model, pretreatment hemoglobin values proved to be an independent prognostic factor for patients with stage I-II epithelial ovarian cancer (n=203), but failed to attain significance in patients with stage III-IV disease (n=350). Tumor anemia defined as pretreatment hemoglobin values <12 g/dl may indicate patients with stage I and II epithelial ovarian cancer, who are at increased risk of relapse.
authors.affiliation: University Hospital of Vienna, Department of Gynecology and Obstetrics, Waehringer Guertel, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Obermair
authors.forename: E
authors.initials: E
authors.lastname: Petru
authors.forename: G
authors.initials: G
authors.lastname: Windbichler
authors.forename: C
authors.initials: C
authors.lastname: Peters-Engl
authors.forename: A H
authors.initials: AH
authors.lastname: Graf
authors.forename: W
authors.initials: W
authors.lastname: Stummvoll
authors.forename: A
authors.initials: A
authors.lastname: Kaider
authors.forename: S
authors.initials: S
authors.lastname: Kurschel
authors.forename: H
authors.initials: H
authors.lastname: Kölbl
authors.forename: P
authors.initials: P
authors.lastname: Sevelda
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000097:blood / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D000740:Anemia / Q000097:blood*; D002277:Carcinoma / Q000097:blood / Q000401:mortality / Q000601:surgery; D018269:Carcinoma, Endometrioid / Q000097:blood / Q000401:mortality / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery*; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D006454:Hemoglobins