Permeation of sumatriptan through human vaginal and buccal mucosa.
Continued interest in the various routes by which sumatriptan may be administered prompted us to investigate its passage through buccal mucosa. Because human buccal mucosa is scarce, we proposed using the relatively abundant vaginal mucosa, which has been shown to have comparable diffusion rates for a number of widely varying molecules, as a model of buccal mucosa. In addition, by comparing these two tissues with respect to their permeability to sumatriptan, the human vaginal/buccal mucosa model could be further evaluated. Clinically healthy human vaginal and buccal mucosa specimens were used in the permeability studies. Permeability to sumatriptan was determined using a continuous flow-through diffusion system in the presence and absence of permeation enhancers. No statistically significant differences in permeability could be demonstrated for both mucosae toward sumatriptan. Flux values obtained in the absence and presence of glycodeoxycholate and lauric acid (1:1 molar ratio) to sumatriptan of buccal and vaginal mucosa, respectively, were not significantly different. The results obtained further support the hypothesis of the vaginal/buccal mucosal in vitro permeability model and suggest that this model may be used in conjunction with various absorption enhancers. Further studies on the buccal route of absorption of sumatriptan are thus warranted.
van der Bijl
P
P
Oral and Dental Research Institute, Faculty of Dentistry, University of Stellenbosch, Tygerberg, South Africa.
Penkler
L
L
van Eyk
A D
AD
D000278:Administration, Buccal; D000282:Administration, Intravaginal; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D009061:Mouth Mucosa / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D010539:Permeability; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage* / Q000737:chemistry*; D018170:Sumatriptan / Q000008:administration & dosage* / Q000737:chemistry*; D014621:Vagina / Q000378:metabolism*
D017366:Serotonin Receptor Agonists; D018170:Sumatriptan