title: Synthesis and structure-activity relationships of novel nikkomycin analogs: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase.
abstract: A series of novel nikkomycin analogs, which inhibited chitin synthase, the fungal cell wall biosynthesis enzyme, has been synthesized and evaluated their inhibitory activities.
authors.affiliation: Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Tochigi-ken, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Uda
authors.forename: K
authors.initials: K
authors.lastname: Obi
authors.forename: K
authors.initials: K
authors.lastname: Iwase
authors.forename: O
authors.initials: O
authors.lastname: Sugimoto
authors.forename: H
authors.initials: H
authors.lastname: Ebisu
authors.forename: A
authors.initials: A
authors.lastname: Matsuda
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002687:Chitin Synthase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D014537:Uridine Diphosphate N-Acetylglucosamine / Q000737:chemistry
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D014537:Uridine Diphosphate N-Acetylglucosamine; C011952:nikkomycin; D002687:Chitin Synthase