title: Activated charcoal as the sole intervention for treatment after childhood poisoning.
abstract: Childhood poisonings account for approximately two thirds of all human toxic exposures reported annually to the American Association of Poison Control Centers. Activated charcoal (AC) is the mainstay of decontamination in the emergency department setting. This review focuses on six concepts: 1) description of AC and its method of action, 2) evolution of AC in the gastrointestinal decontamination process, 3) prehospital use of AC, 4) superactivated charcoal, 5) multiple-dose AC, and 6) complications of AC administration. The most recent evolving trends in decontamination of the pediatric patient include trends toward earlier decontamination, either in the home or by paramedics in the field. The newer, "super" activated charcoals, with their greater surface area, may improve compliance of oral administration of AC. Finally, guidelines have been set to limit use of multiple-dose activated charcoal regimens to certain pharmaceuticals only, as well as discouraging cathartic use with charcoal dosing.
authors.affiliation: Division of Emergency Medicine & the Program in Clinical Pharmacology/Toxicology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. Burns_M@a1.tch.harvard.edu
authors.forename: M M
authors.initials: MM
authors.lastname: Burns
mesh_terms: D002606:Charcoal / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D006801:Humans; D011041:Poisoning / Q000628:therapy*
chemical_list: D002606:Charcoal