Cytokine and cytokine receptor polymorphisms in infectious disease.
Host immune responses strongly control the outcome of infectious disease, and the resistance to bacterial infections in humans is in part genetically determined. Responses to Gram-negative bacterial endotoxin are affected by the concentration of plasma lipoproteins and lipid transport proteins that are genetically controlled. Alterations of plasma lipid profiles by genetic manipulation in mice indeed strongly modify resistance to bacterial infections. Recently, the TLR-4 receptor has been identified as the endotoxin receptor, and TLR-4 mutations are the cause of endotoxin resistance in mice. It is probable that such defects also exist in humans, although they must be rare. The capacity of monocytes to produce TNFalpha varies more than tenfold, and several polymorphisms within the TNFalpha gene have been associated with increased TNFalpha production and increased mortality of sepsis. However, these associations most likely result from linkage disequilibrium with other immune response genes on chromosome 6. Polymorphisms within the IL-1beta and the IL-1RA genes (located on chromosome 2) are associated with altered protein production rates, and certain haplotypes have been linked to inflammatory disease (no studies in bacterial infectious disease have been published). Mutations in the receptors for IL-12 and IFNgamma, both critical for clearance of intracellular infectious pathogens, occur in consanguineous populations and are associated with severe recurrent infections with Salmonella species and mycobacteria. In conclusion, no human cytokine deficiency syndromes are known, and it remains uncertain whether genetically determined differences in the production rate of pro-inflammatory cytokines alter the outcome of sepsis. In contrast, mutations in the IL-12 and IFNgamma receptor (and possibly the endotoxin receptor) genes are associated with recurrent bacterial infections, whereas TNFR1 mutations cause fever of unknown origin.
van Deventer
S J
SJ
Laboratory for Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands. S.J.vanDeventer@amc.uva.nl
D000818:Animals; D001424:Bacterial Infections / Q000235:genetics* / Q000276:immunology; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D009154:Mutation; D011110:Polymorphism, Genetic; D018121:Receptors, Cytokine / Q000235:genetics* / Q000276:immunology; D018805:Sepsis / Q000235:genetics / Q000276:immunology
D016207:Cytokines; D018121:Receptors, Cytokine