Artificial articular cartilage: mechanoelectrical transduction under dynamic compressive loading.
The search for biomaterials to be used as an artificial articular cartilage in joint restoration is a challenging research area. Because the articular cartilage plays a fundamental role in joint function, the biomaterial has to be able to mimic the behavior of the natural healthy surface. Articular cartilage is a biphasic material composed by a solid extracellular matrix and a fluid phase, the synovial fluid. When the tissue is pressed, there is a mechanoelectrical transduction that is believed to modulate the cellular activity of chondrocytes, being fundamental for tissue repair. This work aimed at the development of hydrogels for use as an artificial articular cartilage. Hydrogels with negative groups fixed in the macromolecular network were obtained by copolymerizing 2-hydroxyethyl methacrylate with acrylic acid. The obtained hydrogels showed a mechanoelectrical transduction under dynamic compressive loading with potential amplitude increasing with fixed charge density values.
Malmonge
S M
SM
Biomechanical Engineering Laboratory, Technology Centre, State University of Campinas, Campinas, São Paulo, Brazil. malmonge@ct.unicamp.br
Arruda
A C
AC
D000179:Acrylates / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D002358:Cartilage, Articular / Q000737:chemistry / Q000502:physiology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D019902:Chondrocytes / Q000502:physiology; D004563:Electrochemistry; D005109:Extracellular Matrix / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D019736:Prostheses and Implants; D011474:Prosthesis Design; D013314:Stress, Mechanical; D013582:Synovial Fluid / Q000737:chemistry; D016474:Weight-Bearing
D000179:Acrylates; D001672:Biocompatible Materials; D020100:Hydrogels; D008689:Methacrylates; C005044:hydroxyethyl methacrylate; C036658:acrylic acid