Novel practical synthesis of Kdn2en and its C-4 nitrogen-modified derivatives.
A practical synthesis of Kdn2en and 4-amino-4-deoxy-Kdn2en has been achieved via a key intermediate, methyl 4,5,7,8,9-penta-O-acetyl-2,6-anhydro-3-deoxy-D-glycero-D-galacto-non-2- enonate, which has been prepared from Kdn in three steps in 91% overall yield.
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School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Sato
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Kai
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Furuhata
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D002845:Chromatography; D004952:Esters / Q000737:chemistry; D008956:Models, Chemical; D008958:Models, Molecular; D009584:Nitrogen / Q000737:chemistry*; D012794:Sialic Acids / Q000138:chemical synthesis*; D013696:Temperature
C105090:2-deoxy-2,3-didehydro-D-glycero-D-galacto-2-nonulopyranosonic acid; D004952:Esters; D012794:Sialic Acids; D009584:Nitrogen