title: Effect of high-grade prostatic intraepithelial neoplasia on total and percent free serum prostatic-specific antigen.
abstract: OBJECTIVE
  To analyze the influence of high-grade prostatic intraepithelial neoplasia (HGPIN) on total serum prostatic-specific antigen (PSA) and percent free PSA.
  
  
  METHODS
  Total and free serum PSA were determined in 81 consecutive patients with clinical T1c prostate cancer who underwent radical prostatectomy. HGPIN was detected in 62 specimens (76.5%).
  
  
  RESULTS
  Median total PSA was 9.2 ng/ml when there was not HGPIN and 8.1 ng/ml when it existed, p>0.05. Median percent free PSA was 11.7 and 9.1%, respectively, p<0.03. However, a multiple linear regression analysis demonstrated there was no effect of HGPIN on total PSA nor on percent free PSA. Percent free serum PSA was significantly influenced by total PSA and the pathological tumor stage.
  
  
  CONCLUSIONS
  HGPIN does not seem to contribute significantly on serum total PSA and percent free PSA.
authors.affiliation: Department of Urology and Prostatic Pathology Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Morote
authors.forename: C X
authors.initials: CX
authors.lastname: Raventós
authors.forename: G
authors.initials: G
authors.lastname: Encabo
authors.forename: M
authors.initials: M
authors.lastname: López
authors.forename: I M
authors.initials: IM
authors.lastname: de Torres
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy / Q000379:methods; D019048:Prostatic Intraepithelial Neoplasia / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric
chemical_list: D017430:Prostate-Specific Antigen