title: Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica.
abstract: Two known diarylheptanoids, oregonin (1), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-heptane-3-one-5-O-beta-D-xylopyranosi de and hirsutanonol (2), (5S)-1,7-bis-(3,4-dihydroxyphenyl)-5-hydroxyheptane-3-one isolated from the bark of Alnus hirsuta var. sibirica, showed significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells.
authors.affiliation: College of Pharmacy, Chung-Ang University, Seoul, Korea.
authors.forename: M W
authors.initials: MW
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: D W
authors.initials: DW
authors.lastname: Jeong
authors.forename: K H
authors.initials: KH
authors.lastname: Ahn
authors.forename: S H
authors.initials: SH
authors.lastname: Toh
authors.forename: Y J
authors.initials: YJ
authors.lastname: Surh
mesh_terms: D002461:Cell Line, Transformed; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D036381:Diarylheptanoids; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000494:pharmacology*; D008565:Membrane Proteins; D010946:Plants, Medicinal / Q000737:chemistry*; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology*; D013729:Terpenes / Q000494:pharmacology*; D014197:Trees / Q000737:chemistry
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D036381:Diarylheptanoids; D006027:Glycosides; D007527:Isoenzymes; D008565:Membrane Proteins; D013729:Terpenes; C409457:hirsutanonol; C409456:oregonin; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases