Use of diclofenac in children with asthma.
This study investigated the effect of diclofenac on the lung function of 70 children aged 6-15 years with a diagnosis of asthma, recruited from a hospital respiratory clinic. Peak flow and a forced expiratory flow-volume loop were measured and the patients were then given 1-1.5 mg.kg-1 effervescent diclofenac orally. Spirometry was repeated at 10, 20 and 30 min, a 15% decrease in results being considered a significant reduction in lung function. No patient demonstrated a consistent reduction in lung function of > 15% during the study and there were no reports of wheezing or increased bronchodilator use after completion of the spirometry. In conclusion, we studied a group of genuine asthmatics and found no clinically significant incidence of bronchospasm with the use of a single therapeutic dose of diclofenac.
Short
J A
JA
Department of Anaesthesia, Sheffield Children's Hospital, Western Bank, Sheffield S10 2TH, UK.
Barr
C A
CA
Palmer
C D
CD
Goddard
J M
JM
Stack
C G
CG
Primhak
R A
RA
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001249:Asthma / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000139:chemically induced; D002648:Child; D004008:Diclofenac / Q000009:adverse effects*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D015656:Respiratory Mechanics / Q000187:drug effects*; D013147:Spirometry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac