title: Cardiorespiratory and metabolic responses to exercise in HbSC sickle cell patients.
abstract: OBJECTIVE
  Relative to healthy control individuals with normal hemoglobin (Hb), patients carrying the double heterozygous form of sickle cell disease (HbSC) display an impaired oxygen transport capacity. The present study was undertaken to determine the influence of the decreased oxygen availability associated with the presence of HbSC on the cardiorespiratory and metabolic responses to endurance exercise.
  
  
  METHODS
  Eleven black men affected by the double heterozygous form of the sickle cell disease (HbSC group) and seven healthy subjects with normal Hb (HbAA group) of the same ethnic origin submitted successively to an incremental exercise test to exhaustion on a cycle ergometer for the determination of their maximal tolerated power and to a 20-min endurance exercise.
  
  
  RESULTS
  The HbSC had a significantly lower exercise tolerance than the HbAA. During the endurance exercise, they exhibited furthermore significantly lower VO2, VCO2, and minute ventilation V(E) than the HbAA. Despite the fact that the HbSC exercised at a significantly lower mean absolute work rate than the HbAA, except for the ventilatory equivalent for CO2 (V(E)/VCO2), which was higher (P < 0.001) in the HbSC group, the other parameters recorded during the 20-min endurance exercise (heart rate, arterial PaO2, PaCO2, pH, lactate, and VE/VO2, the ventilatory equivalent for O2) and during the subsequent recovery (blood lactate) were similar for both groups.
  
  
  CONCLUSIONS
  The study underscores the importance of considering relative work rate as well as absolute work rate to arrive at a correct interpretation of exercise and recovery data. The results give evidence that the modifications of homeostasis brought into play by exercise were shifted toward distinctly lower absolute work rates in HbSC patients.
authors.affiliation: Laboratoire de Physiologie Appliquée, Faculté de Médecine, Strasbourg, France.
authors.forename: S
authors.initials: S
authors.lastname: Oyono-Enguéllé
authors.forename: D
authors.initials: D
authors.lastname: Le Gallais
authors.forename: A
authors.initials: A
authors.lastname: Lonsdorfer
authors.forename: C
authors.initials: C
authors.lastname: Dah
authors.forename: H
authors.initials: H
authors.lastname: Freund
authors.forename: P
authors.initials: P
authors.lastname: Bogui
authors.forename: J
authors.initials: J
authors.lastname: Lonsdorfer
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006450:Hemoglobin SC Disease / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D010100:Oxygen / Q000378:metabolism
chemical_list: D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen