Synthesis and anti-HIV activity of unusual nucleoside oxanosine derivatives.
A series of the oxanosine and carbocyclic oxanosine derivatives were synthesized to evaluate for their anti-HIV activity. Compound 1, 7 and 9 showed weak anti-HIV activities.
Saito
Y
Y
Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
Chaicharoenpong
C
C
Ohno
O
O
Ichikawa
E
E
Yamamura
S
S
Kato
K
K
Nakamura
M
M
Ohno
T
T
Umezawa
K
K
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020298:U937 Cells
D019380:Anti-HIV Agents; D007202:Indicators and Reagents; D012263:Ribonucleosides; C032886:oxanosine