Microbial transformation of benzosampangine.
Microbial transformation studies of the synthetic antifungal alkaloid benzosampangine (1) have revealed that 1 is metabolized by a number of microorganisms. Using a standard two-stage fermentation technique Absidia glauca (ATCC 22752), Cunninghamella blakesleeana (ATCC 8688a), Cunninghamella species (NRRL 5695), Fusarium solani f. sp. cucurbitae (CSIH #C-5), and Rhizopogon species (ATCC 36060) each produced a beta-glucopyranose conjugate of benzosampangine (2). The identity of 2 was established on the basis of spectroscopic data.
Orabi
K Y
KY
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
Clark
A M
AM
Hufford
C D
CD
D000470:Alkaloids / Q000737:chemistry / Q000493:pharmacokinetics*; D005658:Fungi / Q000378:metabolism*; D006576:Heterocyclic Compounds, 4 or More Rings; D015394:Molecular Structure; D009287:Naphthyridines; D011804:Quinolines; D013057:Spectrum Analysis
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; D009287:Naphthyridines; D011804:Quinolines; C407995:benzosampangine