[Phenotypic expression of Lp(a) in Spanish children and adolescents].
BACKGROUND
To know the distribution of phenotypes Lp(a) in an young population.


METHODS
Lipoprotein levels, lipoprotein(a), apolipoproteins and the Lp(a) phenotypes were determined in 105 children, selected according to their cholesterol concentrations.


RESULTS
The Lp(a) concentrations were significantly higher in group with low molecular weight respect to group with high molecular weight. The most frequent isoform was S3.


CONCLUSIONS
The Lp(a) concentrations correlate inversely with the molecular weight of Apo(a) isoforms.
Gómez Gerique
J A
JA
Departamento de Bioquímica Clínica, Fundación Jiménez Díaz, Madrid. jagomezg@meditex.es
López Martínez
D
D
Cancelas
P
P
Montoya
M T
MT
Gutiérrez
M D
MD
Porres
A
A
D000293:Adolescent; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics; D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D004587:Electrophoresis, Agar Gel / Q000379:methods; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D015151:Immunoblotting; D017270:Lipoprotein(a) / Q000097:blood / Q000235:genetics*; D008297:Male; D008970:Molecular Weight; D017202:Myocardial Ischemia / Q000097:blood / Q000235:genetics; D010641:Phenotype; D011159:Population Surveillance; D020033:Protein Isoforms / Q000235:genetics; D013030:Spain
D001054:Apolipoproteins A; D001055:Apolipoproteins B; D017270:Lipoprotein(a); D020033:Protein Isoforms; D002784:Cholesterol