Using one- and two-dimensional NMR techniques to characterize reaction products bound to Chiron SynPhase crowns.
Solid-phase MAS techniques have proved to be very useful in characterizing compounds bound to resin; however, little has been reported on using NMR to characterize compounds attached to Chiron SynPhase crowns. We have used proton, carbon, and COSY spectra obtained with a Varian Nano.nmr probe to characterize products from a published reaction sequence attached to MD (methacrylic acid/dimethylacrylamide copolymer) crowns. We have also performed solvent surveys to determine the best solvents for acquiring spectra of materials bound to both MD and PS (polystyrene) crowns.
Sefler
A M
AM
Glaxo Wellcome, Inc., North Carolina 27709, USA. as33917@glaxowellcome.com
Gerritz
S W
SW
D000178:Acrylamides; D002625:Chemistry, Organic; D004988:Ethers, Cyclic / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008280:Magnetics; D008689:Methacrylates; D055601:Organic Chemistry Phenomena; D011522:Protons; D012997:Solvents
D000178:Acrylamides; D004988:Ethers, Cyclic; D008689:Methacrylates; D011522:Protons; D012997:Solvents; C045985:methacrylamide