Relative and absolute configurations of ganefromycin alpha.
The full structure of ganefromycin alpha has been determined. The relative configurations were determined from 3JH,H coupling constants and NOE data, while the absolute configurations in moleties A and B were determined separately by difference CD of their acylate derivatives, which showed typical exciton couplets. The configurations of the stereogenic centers in ganefromycin alpha are 8S, 9S, 11R, 12S, 13S, 21S, 22R, 23R, 24R, and 26S.
Andersson
T
T
Department of Chemistry, Columbia University, New York, New York 10027, USA.
Berova
N
N
Nakanishi
K
K
Carter
G T
GT
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002942:Circular Dichroism; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C058741:phenelfamycin E