Expression of variant CD44 containing variant exon v8-10 in gallbladder cancer.
We studied the Cd44v8-10 expression in gallbladder cancer immunohistochemically. Eighteen of 37 gallbladder cancer tissues expressed CD44v8-10. There were significant correlations between CD44v8-10 immunoreactivity and perineural invasion, venous invasion, and lymph node metastasis. Patients with CD44v8-10-positive tumors showed poor prognoses, whereas those with CD44v8-10-negative tumors had favorable prognoses. A multivariate analysis using the Cox regression model showed the immunoreactivity of CD44v8-10 to be an independent prognostic indicator of gallbladder cancer. The results suggest that CD44v8-10 expression may be a biologic marker of prognostic significance in gallbladder cancer.
Yamaguchi
A
A
First Department of Surgery, Fukui Medical University, Yoshida-gun, Fukui 910-1193, Japan.
Zhang
M
M
Goi
T
T
Fujita
T
T
Niimoto
S
S
Katayama
K
K
Hirose
K
K
D015703:Antigens, CD / Q000032:analysis / Q000235:genetics; D018572:Disease-Free Survival; D005706:Gallbladder Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D014644:Genetic Variation; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis / Q000235:genetics*; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors
D015703:Antigens, CD; D018960:Hyaluronan Receptors