Pituitary adenylate cyclase-activating polypeptide induces hyperthermia in the rat.
The effects of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) on body temperature were investigated in rats. Intracerebroventricular (i.c.v.) administration of PACAP-38 in doses of 500 and 1000 ng induced a dose-related elevation in colon temperature 2, 3, 4, 5 and 6 h after injection. The i.c.v. pretreatment of the animals with different dilutions of PACAP-38 antiserum prevented the development of hyperthermia in PACAP-38-treated animals, whereas PACAP-38 antiserum alone did not modify the colon temperature. An intramuscular injection of noraminophenazone (a cyclooxygenase inhibitor) abolished the PACAP-38-induced hyperthermia. Our data indicate that PACAP may induce hyperthermia via the central nervous system, and this hyperthermic effect may be mediated via a cyclooxygenase-involved pathway.
Pataki
I
I
Department of Pathophysiology, Albert Szent-Györgyi Medical University, MTA-SZOTE Neurohumoral Research Group, Semmelweis u. 1, PO Box 531, H-6701, Szeged, Hungary.
Adamik
A
A
Jászberényi
M
M
Mácsai
M
M
Telegdy
G
G
D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D003106:Colon / Q000187:drug effects / Q000502:physiology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced* / Q000503:physiopathology; D007276:Injections, Intraventricular; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D017208:Rats, Wistar
C495403:Adcyap1 protein, rat; D016861:Cyclooxygenase Inhibitors; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D000632:Aminopyrine