Effects of hormonal replacement treatment on bone mineral density and metabolism in hypogonadal patients.
We investigated 22 male patients affected by prepubertal hypogonadism with a mean age of 34.3+/-5.2. A significant reduction of bone mineral density (BMD) at both the lumbar spine (L2-L4, -14%, 1.039+/-0.11 vs. 1.217+/-0.16 g/cm(2), P=0.005) and femoral neck (-11%; 0.927+/-0.09 vs. 1.034+/-0.16 g/cm(2), P=0.01) was found in patients compared to age-matched controls. The mean Z score was -1. 55 for vertebrae and -1.33 for femur. Eleven and nine patients, respectively, had a lumbar and femoral BMD at least 1 S.D. below the normal mean; 8 and 4, respectively, 2 S.D. below. There was a strong positive correlation between BMD and duration of hormone replacement treatment (HRT) for both sites: respectively, r=0.71, P<0.005 for the vertebrae, and r=0.60, P<0.01 for the femur. A weak correlation was also present between onset of HRT and BMD: r=0.6, P<0.01 at the lumbar level, and r=0.47, P<0.05 at the femoral neck.
Canale
D
D
Dipartimento di Endocrinologia, Università di Pîsa, Ospedale di Cisanello, via Paradisa, 2, 56124, Pisa, Italy. endo@endoc.med.unipi.it
Vignali
E
E
Golia
F
F
Martino
E
E
Pinchera
A
A
Marcocci
C
C
D000328:Adult; D017668:Age of Onset; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects; D016022:Case-Control Studies; D005272:Femur Neck; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000151:congenital / Q000188:drug therapy / Q000378:metabolism*; D016014:Linear Models; D008161:Lumbosacral Region; D008297:Male; D016555:Matched-Pair Analysis; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood / Q000652:urine
D013739:Testosterone