[The effect of GABA-positive agents on the formation of morphine dependence and on the manifestations of a withdrawal syndrome].
Experiments on mice showed that the GABA-positive preparations (THIP, baclofen, fenibut, valproate sodium) intraperitoneally injected in the course of the morphine addiction development (double daily subcutaneous injections at a dose increasing from 10 to 100 mg/kg over a period of 8 days) and, to a greater extent, upon cessation of the morphine injections, partly reduce manifestations of the naloxone-enhanced (0.1 mg/kg, s.c.) daily abstinence, as evaluated by the hopping activity and pair interaction tests.
Belozertseva
I V
IV
Val'dman Institute of Pharmacology, Pavlov Medical University, St. Petersburg, Russia.
Andreev
B V
BV
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D018755:GABA Agonists / Q000627:therapeutic use*; D018756:GABA Antagonists / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D009020:Morphine / Q000009:adverse effects*; D009021:Morphine Dependence / Q000188:drug therapy* / Q000209:etiology; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D009294:Narcotics / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
D018755:GABA Agonists; D018756:GABA Antagonists; D009292:Narcotic Antagonists; D009294:Narcotics; D009270:Naloxone; D009020:Morphine