A new region of synteny between human chromosome 1p22 and mouse chromosome 5.
By constructing a physical map of the p22 region of human chromosome 1 we have been able to show the relative orientation of four genes; GFI1, NB4S/EVI5, RPL5 and DR1. Analysis of the mouse physical map shows that the murine orthologs of these genes are located on mouse chromosome 5. Through this analysis we have established a new region of synteny between mouse chromosome 5 and human chromosome region 1p22.
Chelsea
D M
DM
Center for Molecular Genetics/NB20, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Roberts
T
T
Cowell
J K
JK
D000818:Animals; D018797:Cell Cycle Proteins; D002874:Chromosome Mapping; D002875:Chromosomes; D018244:Chromosomes, Artificial, Yeast; D002878:Chromosomes, Human, Pair 1; D004268:DNA-Binding Proteins / Q000235:genetics; D020690:GTPase-Activating Proteins; D006801:Humans; D051379:Mice; D010750:Phosphoproteins / Q000235:genetics; D012269:Ribosomal Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; C105043:Evi5 protein, mouse; C498275:GFI1 protein, human; D020690:GTPase-Activating Proteins; C079873:Gfi1 protein, mouse; D010750:Phosphoproteins; D012269:Ribosomal Proteins; D014157:Transcription Factors; C075995:down-regulator of transcription 1; C029742:ribosomal protein L5