Linkage between quantitative trait loci and marker loci: resolution power of three statistical approaches in single marker analysis.
This paper presents a comparison of three methods of parameter estimation in analysis of linkage between a quantitative trait locus (QTL) and a marker locus: maximum likelihood, mean square for trait cumulative distribution function, and method of moments, employing simulated backcross data. The sensitivity of estimates to violation of assumptions of normality and equal variances were also studied. Some measures of discrepancy between the trait distributions in the QTL groups are considered to evaluate the potential dependence of the resolution capacity of the QTL substitution effect with respect to trait mean value and variance.
Korol
A B
AB
Institute of Evolution, University of Haifa, Mount Carmel, Haifa 31905, Israel.
Ronin
Y I
YI
Kirzhner
V M
VM
D000465:Algorithms; D005819:Genetic Markers; D016013:Likelihood Functions; D016014:Linear Models; D015233:Models, Statistical; D009010:Monte Carlo Method; D019655:Quantitative Trait, Heritable; D011995:Recombination, Genetic
D005819:Genetic Markers