[The reduction of dyslipidemia and oxidative stress in experimental diabetes mellitus treated with probucol].
There is considerable controversy regarding the role of oxidative stress in development of macro and microangiopathy in diabetes--a free radical associated disease. Increasing the oxidative glycosylation of plasma lipoproteins by reactive oxygen species (ROS) and reduction of scavenging system under conditions of hyperglycemia may accelerate diabetic vascular disease. We have investigated the effect of Probucol (P) a drug with strong lipophilic radical scavenger action, on plasma lipoproteins variations, malondialdehid (MDA) production, atherosclerotic index (total Cholesterol/HDL Cholesterol), glycemia and glucosuria in Wistar male alloxanic rats with/without enriched cholesterol diet. The inhibition of lipoproteins oxidation, resulting from diminishing MDA, in our study, would furthermore delay the absorption and penetration of lipids and lipoproteins into deeper vascular layers and thereby reduce the risk of atherosclerotic vascular lesion. Our result suggest that treatment with inhibitors of lipoproteins oxidation may reduce the risk of cardiovascular complications in diabetes.
Colev
V
V
Catedra de Fiziopatologie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Păduraru
I
I
Vornicu
M
M
Bădescu
M
M
Mocanu
V
V
Ciocoiu
M
M
Saramet
A
A
Bohotin
C
C
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D011341:Probucol / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D016166:Free Radical Scavengers; D000960:Hypolipidemic Agents; D008055:Lipids; D011341:Probucol