Integrins: regulators of embryogenesis.
Integrins are heterodimeric transmembrane glycoproteins involved in cell-cell and cell-extracellular matrix adhesion. They also participate in cytoskeletal rearrangements, co-regulation of growth factor activities and activation of signal transductions. This review describes experimental approaches that have given new insights into the integrin functions during embryogenesis. Using anti-functional antibodies, peptide inhibitors of integrin-ligand interactions and genetic ablation of integrins results, this review will show that integrins are key molecules during early development of both invertebrates and vertebrates.
Darribère
T
T
Université P.-et-M.-Curie, U.M.R.-CNRS 7622, Laboratoire de Biologie Moléculaire et Cellulaire du Développement, Equipe Adhesion et Migration Cellulaires, Paris, France.
Skalski
M
M
Cousin
H L
HL
Gaultier
A
A
Montmory
C
C
Alfandari
D
D
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D004622:Embryo, Mammalian / Q000166:cytology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology*
D016023:Integrins