MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals.
Eperezolid and linezolid are representatives of a new class of orally active, synthetic antimicrobial agents. The in vitro activity values (MICs) of linezolid, eperezolid, and comparator antibiotics against 102 strains of Rhodococcus equi isolated from humans and animals were determined. Linezolid was more active than eperezolid against the strains tested; premafloxacin was the most active comparator antibiotic.
Bowersock
T L
TL
Animal Health Therapeutics Research, Pharmacia & Upjohn, Kalamazoo, Michigan 49001, USA. Terry.L.Bowersock@am.pnu.com
Salmon
S A
SA
Portis
E S
ES
Prescott
J F
JF
Robison
D A
DA
Ford
C W
CW
Watts
J L
JL
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006736:Horses; D006801:Humans; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D016929:Rhodococcus equi / Q000187:drug effects* / Q000302:isolation & purification
D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; D023303:Oxazolidinones; C098011:eperezolid; D000069349:Linezolid