title: Bivalve metallothionein as a biomarker of aquatic ecosystem pollution by trace metals: limits and perspectives.
abstract: Owing to their induction by metals metallothioneins (MTs) have been proposed as biomarkers of the metallic contamination of the environment. On the other hand, bivalves are regarded as very convenient bioindicators of the aquatic ecosystems and an extensive literature has been dedicated to their response to metals. Among studies supporting the involvement of MTs in metal detoxification some discrepancy appears due to inter- and intra-specific variations, or to heterogeneous exposure conditions. A lesser number of papers are dealing with the use of metallothionein levels as biomarkers, and sometimes they evidence that natural factors influencing metallothionein synthesis have to be taken into account before final conclusions can been drawn. Moreover, there is still a large number of non-intercalibrated protocols used to quantify amounts of metallothioneins in organisms. As comparisons are necessary to assess the relative abundance of metallothioneins in a studied species, more work has to be completed before such comparisons could be validated. In the present paper we wish to establish the limits of the use of mollusc metallothioneins as a biomarker of aquatic ecosystem contamination by trace metals, using published and recent data as support for our conclusions and perspectives.
authors.affiliation: ISOMer, Laboratoire de Biologie Marine, Nantes, France. cosson@isomer.univ-nantes.fr
authors.forename: R P
authors.initials: RP
authors.lastname: Cosson
mesh_terms: D000818:Animals; D015415:Biomarkers; D049872:Bivalvia / Q000737:chemistry*; D008628:Mercury / Q000737:chemistry; D008668:Metallothionein / Q000737:chemistry* / Q000302:isolation & purification; D010125:Ostreidae / Q000737:chemistry*; D011048:Polarography; D020033:Protein Isoforms; D012621:Seasons; D013053:Spectrophotometry; D014876:Water Pollution
chemical_list: D015415:Biomarkers; D020033:Protein Isoforms; D008668:Metallothionein; D008628:Mercury