[The repair processes and cell populations relationship in bone marrow of patients with acute radiation injury: morphological study].
The results of bone marrow pathomorphologic investigation in patients who died of acute radiation sickness (3.7-13.7 Gy) after the Chernobyl accident are presented. Stratification into three consecutive periods was performed according to the length of postexposure survival (14-96 days) and the morphologic picture dynamics: 1) bone marrow aplasia (2-3 weeks after exposure) with a domination of stromal and plasma cell populations, exhibiting the morphologic characteristics of functional activity; 2) initial repair period (3-4 weeks after exposure) was characterized by the beginning of hematopoietic proliferation with simultaneous occurrence of cell death via apoptosis; 3) active repair period (4 and more weeks after exposure) was defined by increased marrow cellularity (trilineage regeneration), accompanied by decreased number of plasma cells and occurrence of large granular lymphocytes.
Kvacheva
Iu E
IuE
Russian State Research Center, Institute of Biophysics, Moscow. ibphgen@rcibph.dol.ru
D000208:Acute Disease; D001854:Bone Marrow Cells / Q000473:pathology*; D002450:Cell Communication; D006801:Humans; D011210:Power Plants; D011832:Radiation Injuries / Q000473:pathology*; D018788:Radioactive Hazard Release; D014455:Ukraine