Urinary 1-hydroxypyrene as a biomarker of polycyclic aromatic hydrocarbons exposure of workers on a contaminated site: influence of exposure conditions.
The aim of the study was to determine the exposure levels of workers to polycyclic aromatic hydrocarbons on gasworks sites by the measurement of urinary 1-hydroxypyrene. Start-shift and end-shift urine samples were taken every day during an entire week (Monday to Friday), once in November and a second time in June. Four groups of workers were selected according to their activity. Increased exposure was only found among volunteers involved in the remediation of a site, 0.16 to 2.31 mumol/mol creatinine in non-smokers. The median of the non-smoker referent group was 0.02 mumol/mol creatinine (95% confidence interval, 0.01 to 0.04). Smokers had greater exposure levels than non-smokers in every group. Within and between variability was around 200%. Assessment of the exposure of persons on contaminated soil is possible, with the condition that the exposed subjects come in direct contact with the soil.
Dor
F
F
Agence de l'Environnement et de la Maîtrise de l'Energie, Paris, France.
Haguenoer
J M
JM
Zmirou
D
D
Empereur-Bissonnet
P
P
Jongeneelen
F J
FJ
Nedellec
V
V
Person
A
A
Ferguson
C C
CC
Dab
W
W
D000704:Analysis of Variance; D015415:Biomarkers; D005260:Female; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D010297:Paris; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*; D011721:Pyrenes / Q000378:metabolism*; D012907:Smoking; D012989:Soil Pollutants / Q000652:urine*
D015415:Biomarkers; D011084:Polycyclic Aromatic Hydrocarbons; D011721:Pyrenes; D012989:Soil Pollutants; C033146:1-hydroxypyrene