title: [Hodgkin's disease. Etiopathogenic role of Epstein-Barr virus in Tarragona].
abstract: BACKGROUND
  The aim of this study is to assess the proportion of Hodgkin disease (HD) expressing Epstein-Barr virus (EBV) in our area (Tarragona-Spain).
  
  
  METHODS
  A retrospective study was performed on paraffin embedded HD tissues from 49 patients to examine the presence of latent membrane protein (LMP-1) by immunohistochemistry and for EBER-1 in situ hybridization.
  
  
  RESULTS
  Overall, EBV (EBER-1 and/or LMP positive) was expressed in 20 cases (40.8%). This percentage was higher, but not significant, in mixed cellularity, and significant higher in patients over 55 years old. No differences between sexes were observed.
  
  
  CONCLUSIONS
  EBV is associated with 40.8% of HD in area of Tarragona.
authors.affiliation: Servicio de Patología, Hospital de Tortosa Verge de la Cinta, Tortosa, Tarragona. htvcap@tinet.fut.es
authors.forename: R
authors.initials: R
authors.lastname: Bosch Príncep
authors.forename: T
authors.initials: T
authors.lastname: Alvaro Naranjo
authors.forename: R
authors.initials: R
authors.lastname: Balanzá Roure
authors.forename: M T
authors.initials: MT
authors.lastname: Salvadó Usach
authors.forename: S
authors.initials: S
authors.lastname: Martínez González
authors.forename: E
authors.initials: E
authors.lastname: Contreras Barbeta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D004854:Herpesvirus 4, Human; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain