title: The rôle of thymidine phosphorylase/PD-ECGF in cancer chemotherapy: a chemical perspective.
abstract: The angiogenic growth factor thymidine phosphorylase/PD-ECGF has been identified as a potential target in the development of anti-cancer drugs. This review firstly discusses the biological rôle of TP/PD-ECGF and its importance in the activation of 5-fluorouracil and its prodrugs. The chemistry and chemotherapeutic potential of TP/PD-ECGF inhibitors are also discussed.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, UK.
authors.forename: C
authors.initials: C
authors.lastname: Cole
authors.forename: A J
authors.initials: AJ
authors.lastname: Foster
authors.forename: S
authors.initials: S
authors.lastname: Freeman
authors.forename: M
authors.initials: M
authors.lastname: Jaffar
authors.forename: P E
authors.initials: PE
authors.lastname: Murray
authors.forename: I J
authors.initials: IJ
authors.lastname: Strafford
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D001711:Biotransformation; D004791:Enzyme Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009389:Neovascularization, Pathologic; D013939:Thymidine Phosphorylase / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013939:Thymidine Phosphorylase