Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue.
New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors.
Vidal
A
A
Laboratoire de Chimie Biomoléculaire et Interactions Biologiques associé au C.N.R.S., Université Montpellier 1, Faculté de Pharmacie, France.
Durand
T
T
Vidal
J P
JP
Rossi
J C
JC
Ravasi
S
S
Zarini
S
S
Sala
A
A
D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D017572:Leukotriene A4 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D017997:Leukotriene C4 / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000378:metabolism
C412032:19-((2-azido-5-iodo)benzoyloxy)leukotriene A(4); C412033:19-((2-azido-5-trimethylstannyl)benzoyloxy)leukotriene A(4); D017572:Leukotriene A4; D009947:Organotin Compounds; D017997:Leukotriene C4; D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase