Photobiology of Monodelphis domestica.
The gray, short-tailed opossum, Monodelphis domestica, has been used for photobiologic studies since 1984. The presence of a light-activated DNA repair pathway in the tissues of Monodelphis has been used to identify pyrimidine dimers in DNA as initiating events for a number of ultraviolet radiation (UVR)-induced pathologies of the skin and cornea. Furthermore, Monodelphis, unlike common laboratory rodents, is susceptible to the induction of melanoma by UVR alone.
Ley
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Department of Cell Biology and Physiology and the Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Reeve
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Kusewitt
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D000818:Animals; D003315:Cornea / Q000528:radiation effects*; D004260:DNA Repair; D003877:Dermatitis, Contact / Q000188:drug therapy; D004139:Dinitrofluorobenzene / Q000494:pharmacology; D004195:Disease Models, Animal; D005134:Eye Neoplasms / Q000209:etiology; D008545:Melanoma / Q000209:etiology; D051379:Mice; D008819:Mice, Nude; D009893:Opossums; D010081:Oxazolone / Q000494:pharmacology; D018462:Photobiology; D011740:Pyrimidine Dimers / Q000528:radiation effects; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014560:Urocanic Acid / Q000032:analysis
D011740:Pyrimidine Dimers; D010081:Oxazolone; D004139:Dinitrofluorobenzene; D014560:Urocanic Acid