[The neurochemical profile of the caudate nucleus in the anxiolytic action of benzodiazepine and nonbenzodiazepine tranquilizers on different models of anxiety].
In the experiments on rats in avoidance response to "eliminated area" and "threatening situation" it is found that the microinjection of monoamines and amino-acids of mediator action, adreno- and dophaminemimetics, their antagonists, and blocker of GABAA receptors picrotoxine into dorsal and ventral sections of caudate nucleus elucidates different functional value and neurochemical special features of examined neostriatum specimens in realization of anxiety states of different origin. Local injection of chlordiazepoxide, phenibutum, indoterum, campirone and campironine into aforementioned sections of the caudate nucleus reduces the state of anxiety in "eliminated area" and/or "threatening situation" response tests thus revealing the similarity with well-known effects of GABA and serotonin and substantial difference in the effects of catecholamines and glutamine acid. It is found that anti-anxious effect of benzodiazepine and nonbenzodiazepine anxiolytics can be mediated through participation of neuron matrices of dorsal and ventral sections of the caudate nucleus having functionally ambiguous neurochemical profile.
Talalaenko
A N
AN
A. M. Gorkiĭ Donetsk Medical University, Pharmacology Department, Ukraine.
Gordienko
D V
DV
Markova
O P
OP
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000378:metabolism; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001569:Benzodiazepines; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines