The role of costimulatory molecules as targets for new immunosuppressives in transplantation.
T-cell costimulation is critical for all T-cell-mediated immune responses that are responsible for endpoints such as allograft rejection or autoimmune disease. Recent experimental data elucidate specific pathways for T-cell activation and negative regulatory mechanisms via unique costimulatory molecules. These data have implications for the development of novel therapeutic strategies to prevent graft rejection and improve long-term graft survival in transplant patients, and to treat autoimmune diseases in humans.
Kishimoto
K
K
Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Boston, Massachussetts 02115, USA.
Dong
V M
VM
Sayegh
M H
MH
D015703:Antigens, CD / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology* / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D008213:Lymphocyte Activation; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D015703:Antigens, CD