title: Isoniazid-related copper(II) and nickel(II) complexes with antimycobacterial in vitro activity. Part 9.
abstract: Isonicotinoylhydrazones 1, obtained by the primary antituberculous agent Isoniazid, have been used as monoanionic ligands (L) to prepare copper(II) 2 and nickel(II) 3 octahedral complexes of stoichiometry [MeL2(H2O)2]. Their antimycobacterial in vitro activity was evaluated against Mycobacterium tuberculosis H37Rv in comparison with the ligands. Complexes 2a, 2b, 2f, 3b, 3d and 3g displayed MIC values < or = 0.2 microg/mL.
authors.affiliation: Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Bottari
authors.forename: R
authors.initials: R
authors.lastname: Maccari
authors.forename: F
authors.initials: F
authors.lastname: Monforte
authors.forename: R
authors.initials: R
authors.lastname: Ottanà
authors.forename: E
authors.initials: E
authors.lastname: Rotondo
authors.forename: M G
authors.initials: MG
authors.lastname: Vigorita
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007538:Isoniazid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D009942:Organometallic Compounds; D007538:Isoniazid