title: Chemotherapy for Advanced Gastric Cancer: Focus on New Agents and Combinations.
abstract: BACKGROUND: Although many treatments for advanced gastric cancer have been developed, systemic therapy remains elusive. METHODS: The author reviewed data on recent phase II and III trials of the main new agents and combinations. RESULTS: Chemotherapy appears to improve survival of patients with advanced disease, albeit slightly. New drugs that might improve response rates and survival include the taxanes. CONCLUSIONS: New combinations, including the taxanes, must be designed and evaluated to further improve the outcome for patients with advanced gastric cancer.
authors.affiliation: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.initials: AM
authors.lastname: Murad