title: The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity.
abstract: A solid phase synthesis of substituted tetrahydroisoquinolines was developed and used to prepare directed libraries of compounds for screening against the protein phosphatase, CDC25B. From these libraries, a compound was found having approximately a 4-fold improvement in activity.
authors.affiliation: Medicinal Chemistry Research, Pharmacia & Upjohn Company, Kalamazoo, MI, 49001, USA. edward.1.fritzen@am.pnu.com
authors.forename: E L
authors.initials: EL
authors.lastname: Fritzen
authors.forename: A S
authors.initials: AS
authors.lastname: Brightwell
authors.forename: L A
authors.initials: LA
authors.lastname: Erickson
authors.forename: D L
authors.initials: DL
authors.lastname: Romero
mesh_terms: D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
chemical_list: D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D007546:Isoquinolines; C412030:PNU 108937; D020687:cdc25 Phosphatases