Sex differences in left ventricular geometry in aortic stenosis: impact on outcome.
OBJECTIVE
This study of surgical aortic stenosis characterized sex differences in left ventricular (LV) geometry and outcome.


METHODS
We examined 92 women and 82 men who underwent echocardiography before valve replacement for aortic stenosis.


RESULTS
Women had a smaller cavity size (LV end-diastolic diameter 48.2 +/- 7 mm in women vs 53.6 +/- 7.6 mm in men; p = 0.0001) and higher ejection fraction (59% in women vs 54% in men; p = 0.02). LV mass was greater in men than women (300.4 +/- 88 g in men vs 250.6 +/- 85.8 g in women; p = 0.0055) but when corrected for body surface area, the difference was not significant. The prevalence of LV hypertrophy was similar in both sexes (51% in women vs 49% in men; p = 0.62). The 5-year survival was 82% in women and 79% in men (p = 0. 9).


CONCLUSIONS
Several descriptors of LV geometry differed between men and women. These differences were largely eliminated after normalizing for body surface area. No differences in surgical mortality or long-term outcome were noted.
Milavetz
D L
DL
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
Hayes
S N
SN
Weston
S A
SA
Seward
J B
JB
Mullany
C J
CJ
Roger
V L
VL
D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000601:surgery; D015150:Echocardiography, Doppler; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D015995:Prevalence; D012189:Retrospective Studies; D012727:Sex Characteristics; D015996:Survival Rate; D016896:Treatment Outcome; D016277:Ventricular Function, Left