title: Early inflammatory cytokine and acute phase protein response under the stress of thermal injury in rats.
abstract: The acute inflammatory response associated with thermal injury was examined in rats. The appearance of mediators of inflammation in the systemic circulation, including cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF) and interleukin-6 (IL-6) and acute phase proteins were assessed during initial 72 h following thermal injury. Increased levels of activity were noted for all three cytokines, but with a different time-course. While serum IL-1 activity was elevated throughout the 3-day period of observation, the levels of serum TNF activity were enhanced after 12 h and on days 1 and 3 following scalding injury. The values of IL-6 were already increased one hour after thermal injury and increased progressively up to day 1 following scalding. Alpha2-macroglobulin and haptoglobin levels were increased 12 h after thermal injury, rising further on days 1 and 3. Positive correlation was found between the time-course of increased serum IL-6 activity and alpha2-macroglobulin, as well as between TNF and haptoglobin in the serum.
authors.affiliation: Institute for Medical Research, Military Medical Academy, Belgrade, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Kataranovski
authors.forename: Z
authors.initials: Z
authors.lastname: Magić
authors.forename: N
authors.initials: N
authors.lastname: Pejnović
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology*; D000818:Animals; D001831:Body Temperature; D002056:Burns / Q000276:immunology*; D006242:Haptoglobins / Q000378:metabolism; D006400:Hematocrit; D007375:Interleukin-1 / Q000097:blood / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012044:Regression Analysis; D012709:Serum Albumin; D013312:Stress, Physiological / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000276:immunology / Q000378:metabolism
chemical_list: D006242:Haptoglobins; D007375:Interleukin-1; D015850:Interleukin-6; D012709:Serum Albumin; D014409:Tumor Necrosis Factor-alpha; D000511:alpha-Macroglobulins