title: [The effect of gamma-L-glutamyl histamine on the severity of experimental anaphylactic reaction, hormonal status and liver cytochrome p-450].
abstract: gamma-L-Glutamyl-histamine (gamma-GluHA) was synthesized at Department of the chemistry and technology of fine organic compounds M. V. Lomonosov Moscow state academy of fine chemical technology. It was investigated the influence of gamma-L-glutamyl-histamine on the severity of experimental anaphylactic reaction, hormonal content in blood plasma and liver cytochrome P-450. The induction of liver cytochrome P-450, the elevation of hormonal content (thyroxine and glucocorticoids) in blood plasma and decrease of the severity of experimental anaphylactic reaction are observed.
authors.affiliation: Lomonosov State Academy of Fane Chemical Technology, Moscow.
authors.forename: V E
authors.initials: VE
authors.lastname: Nebol'sin
authors.forename: V V
authors.initials: VV
authors.lastname: Krzhechkovskaia
authors.forename: G A
authors.initials: GA
authors.lastname: Zheltukhina
authors.forename: R P
authors.initials: RP
authors.lastname: Evstigneeva
authors.forename: V L
authors.initials: VL
authors.lastname: Kovaleva
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy* / Q000378:metabolism*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006728:Hormones / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D006728:Hormones; C013541:gamma-glutamylhistamine; D006632:Histamine; D003577:Cytochrome P-450 Enzyme System