[Effects of psidium components on cytokine productions in helper T cells and type-I allergy].
Psidium genus Myrtaceae (Psidium) is known to be a chinese medicine with an anti-allergy effect. In the present study, to identify active components in Psidium and investigate mechanisms of its anti-allergy effect, effects of several components isolated from Psidium on cytokine production in helper T cell subtypes, Th1 and Th2 cells, were studied. All components, except methyl gallate, suppressed cytokine production in both Th1 and Th2 cells. Then, effects of methyl gallate on IgE production in a model mouse with type I allergy were studied. Methyl gallate suppressed IgE production in the mouse. Only methyl gallate selectively suppressed Th2-cytokine production.
Kosuge
T
T
Department of Biochemistry, Faculty of Pharmaceutical Science, Hoshi University, Tokyo, Japan.
Shishikura
H
H
Kitanaka
S
S
Toyoshima
S
S
D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000917:Antibody Formation; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D003864:Depression, Chemical; D004195:Disease Models, Animal; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D051379:Mice; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D018926:Anti-Allergic Agents; D016207:Cytokines; D010936:Plant Extracts; D007073:Immunoglobulin E; C052082:methyl gallate; D005707:Gallic Acid