Short duration anaesthesia with medetomidine and ketamine in cynomolgus monkeys.
Cynomolgus monkeys were anaesthetized with either intramuscular ketamine (10 mg/kg or intramuscular ketamine 2 mg/kg and medetomidine 50 microg/kg. Various physiological measurements were made once the animals were safe to handle and again 10 min later. Cardiovascular and respiratory function were well maintained with both regimens but the heart rate was lower and arterial-alveolar carbon dioxide gradient was higher in the animals that received medetomidine. In those animals that received medetomidine, atipamezole was given to reverse the medetomidine but there was no difference in recovery times between the two regimens. Anaesthesia was not entirely reliable with medetomidine/ketamine and we recommend caution when using this mixture.
Young
S S
SS
Department of Allergy, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA. simon.young@spcorp.com
Schilling
A M
AM
Skeans
S
S
Ritacco
G
G
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage; D000317:Adrenergic alpha-Antagonists; D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D019162:Anesthetics, Combined / Q000008:administration & dosage; D000778:Anesthetics, Dissociative / Q000008:administration & dosage; D000818:Animals; D001784:Blood Gas Analysis / Q000662:veterinary; D001794:Blood Pressure; D001831:Body Temperature; D006339:Heart Rate; D007093:Imidazoles; D007273:Injections, Intramuscular / Q000662:veterinary; D007649:Ketamine / Q000008:administration & dosage; D008252:Macaca fascicularis / Q000502:physiology*; D008297:Male; D020926:Medetomidine / Q000008:administration & dosage; D011897:Random Allocation; D012119:Respiration
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D019162:Anesthetics, Combined; D000778:Anesthetics, Dissociative; D007093:Imidazoles; C050701:atipamezole; D007649:Ketamine; D020926:Medetomidine