[The possible functional interaction of serotonin and neuropeptides in embryogenic regulatory processes (experiments on embryos of the mollusk Tritona diomedea)].
Ritanserin and inmecarb hydrochloride, antagonists of serotonin, act cytostatically and teratogenically on early embryos of Tritonia diomedea, a nudibranch mollusk. On the basis of a pharmacological analysis and the type of developmental abnormalities observed, this action appears to be due to disturbances in the functional activity of endogenous serotonin and is associated with damage of to the cytoskeleton. The effects of ritanserin and inmecarb are prevented or attenuated by lipophilic serotonin analogs (serotoninamides of polyenoic fatty acids), as well as by polypeptides isolated from neurons Pd5 and Pd6 of the pedal ganglia of the adult Tritonia. In late embryos (stage of veligers), serotonin and to a lesser extent its lipophilic analogs strongly increase embryonic motility. This effect of serotonin is potentiated by some neuropeptides and inhibited by others. These results provide evidence for functional interaction between serotonin and neuropeptides in the control processes of embryogenesis.
Willows
A O
AO
Washington University, USA.
Nikitina
L A
LA
Bezuglov
V V
VV
Gretskaia
N M
NM
Buznikov
G A
GA
D000818:Animals; D001593:Benzyl Compounds / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects / Q000196:embryology; D007211:Indoles / Q000494:pharmacology; D008974:Mollusca / Q000187:drug effects / Q000196:embryology*; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology*; D016713:Ritanserin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013997:Time Factors
D001593:Benzyl Compounds; D007211:Indoles; D009479:Neuropeptides; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C055071:inmecarb; D016713:Ritanserin; D012701:Serotonin