Remote effects of acute ischemic stroke: A xenon CT cerebral blood flow study.
OBJECTIVE
The purpose of this study was to verify transhemispheric diaschisis in the early hours after an ischemic event.


METHODS
XeCT cerebral blood flow (CBF) studies within 8 h of stroke were studied in 23 patients. Mean CBF was evaluated in the ischemic area, contralateral hemisphere and ipsilateral cerebellum.


RESULTS
A severe CBF reduction was found in the ischemic area (mean 9 +/- 3 ml/100 g/min). The mean CBF in the unaffected hemisphere (33 +/- 10 ml/100 g/min) was 35% less compared to the normal mean value. CBF was decreased in the cerebellum ipsilateral to the stroke (mean 31 +/- 12 ml/100 g/min) suggesting a blood flow depression of the whole brain.


CONCLUSIONS
During the initial hours of cerebral ischemia, the asymptomatic hemisphere demonstrated CBF depression that was part of the global flow reduction.
Rubin
G
G
Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Levy
E I
EI
Scarrow
A M
AM
Firlik
A D
AD
Karakus
A
A
Wechsler
L
L
Jungreis
C A
CA
Yonas
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020771:Anterior Cerebral Artery / Q000000981:diagnostic imaging; D001921:Brain / Q000098:blood supply*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D007839:Functional Laterality; D006801:Humans; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging; D012039:Regional Blood Flow; D020521:Stroke / Q000000981:diagnostic imaging / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D014978:Xenon
D014978:Xenon