title: Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene.
abstract: Glutamate-L-cysteine ligase (GLCL [EC 6.3.2.2], also referred to as gamma-glutamylcysteine synthetase) catalyzes the rate-limiting reaction in the synthesis of the important cellular antioxidant glutathione. GLCL is a heterodimer consisting of a catalytic (GLCLC) and a regulatory (GLCLR) subunit. The structure of the human GLCLC subunit gene, GLCLC, which has been mapped to chromosome 6p12, spans 51.4 kb and consists of 16 exons separated by 15 introns.
authors.affiliation: Department of Pharmacology and The University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Gipp
authors.forename: R T
authors.initials: RT
authors.lastname: Mulcahy
mesh_terms: D001483:Base Sequence; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics*; D005347:Fibroblasts; D005721:Glutamate-Cysteine Ligase / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics*; D008297:Male
chemical_list: D005721:Glutamate-Cysteine Ligase