A central role for the endothelial NADPH oxidase in atherosclerosis.
An increasing body of evidence has demonstrated that NADPH oxidase plays a critical role in several early steps leading toward the development of atherosclerosis. These effects appear to be carried out by both the ability of O2- to act as a small second messenger molecule, and potentially the oxidation of low density lipoprotein by O2-. We describe a model for the initiation and development of atherosclerosis that suggests targeted inhibition of NADPH oxidase as a powerful site for prevention and treatment of this disease.
Meyer
J W
JW
Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Bethesda Avenue, P.O. Box 670524, Cincinnati, OH 45267-0524, USA.
Schmitt
M E
ME
D001161:Arteriosclerosis / Q000201:enzymology*; D004730:Endothelium, Vascular / Q000201:enzymology; D006801:Humans; D008077:Lipoproteins, LDL / Q000378:metabolism; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010084:Oxidation-Reduction; D013481:Superoxides / Q000378:metabolism
D008077:Lipoproteins, LDL; D013481:Superoxides; D019255:NADPH Oxidases