Kaposi's sarcoma-associated herpesvirus: from cell biology to pathogenesis.
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. Here we discuss the putative role of these proteins in KSHV pathogenesis.
Sharp
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Department of Oncology, University College London, United Kingdom.
Boshoff
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D005871:Castleman Disease / Q000382:microbiology; D002453:Cell Cycle; D019288:Herpesvirus 8, Human / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D008223:Lymphoma / Q000382:microbiology; D012514:Sarcoma, Kaposi / Q000382:microbiology*