Measurement of thrombopoietic levels: clinical and biological relationships.
Platelet production is primarily regulated by the thrombopoietic cytokine thrombopoietin (TPO). In most cases thrombopoietin serum levels are determined by the rate of c-mpl receptor-mediated degradation after TPO uptake into platelets and megakaryocytes. The contribution of increased TPO protein synthesis by a translational mechanism was recently appreciated as the cause for hereditary thrombocythemia and will have to be elucidated in other conditions of thrombocytosis in association with increased TPO levels.
Verbeek
W
W
Department of Medicine, Georg August University, Göttingen, Germany.
Faulhaber
M
M
Griesinger
F
F
Brittinger
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood; D000328:Adult; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood / Q000494:pharmacology; D015658:HIV Infections / Q000097:blood; D006402:Hematologic Diseases / Q000097:blood / Q000139:chemically induced / Q000235:genetics; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D018121:Receptors, Cytokine / Q000378:metabolism; D053628:Receptors, Thrombopoietin; D013921:Thrombocytopenia / Q000097:blood; D013922:Thrombocytosis / Q000209:etiology / Q000378:metabolism / Q000821:virology; D013926:Thrombopoietin / Q000097:blood* / Q000187:drug effects
D000970:Antineoplastic Agents; D016207:Cytokines; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D018121:Receptors, Cytokine; D053628:Receptors, Thrombopoietin; C082218:MPL protein, human; D013926:Thrombopoietin