[The effect of measured hypoxia on the development of situational osteopenia].
The influence of gas mixture with low PO2 (90-110 mm Hg) on calcium-phosphorus metabolism and biomechanical properties of femur bones at rats, who were kept under condition of hind-limb unloading during 28-days, has been studied. Loss of calcium and phosphorus during a day was less in rats, who was received gas mixture with lower PO2, than rats who was kept in condition of hind-limb unloading only. Hypoxic gas mixture stabilized mechanical properties of bones tissue in femoral bone of rats. Gas mixture with lower pressure of oxygen retard development of osteopenia and may be used with other corrective methods for situation osteopenia prevention.
Berezovs'kyĭ
V Ia
VIa
A. A. Bogomolets Institute of Physiology, NAS of Ukraine, Kiev.
Litovka
I H
IH
Chaka
O H
OH
D000818:Animals; D001696:Biomechanical Phenomena; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D002118:Calcium / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005269:Femur / Q000378:metabolism / Q000503:physiopathology; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009584:Nitrogen / Q000494:pharmacology / Q000627:therapeutic use; D010100:Oxygen / Q000494:pharmacology / Q000627:therapeutic use; D010758:Phosphorus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D010758:Phosphorus; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen; D002118:Calcium