Immunocytochemical expression of p75LNGFR and trkA in Leydig cells of the human testis.
The authors demonstrate for the first time the immunocytochemical expression of the low-affinity neurotrophic growth factor (NGF) receptor p75LNGFR and the high-affinity NGF receptor trkA in the human testis. Employing the polyclonal anti-p75LNGFR antibody and the polyclonal anti-trkA antibody they report strong immunoreactivity for those antigens in the interstitial Leydig cells. Sertoli cells and some cellular elements of the germinative epithelium were also trkA-positive. These findings implicate the neurotrophic factor NGF and its receptors p75LNGFR and trkA in the autocrine and paracrine regulation of the steroidogenic activity of Leydig cells of the human testis.
Koeva
Y
Y
Histology and Embryology Department, Higher Medical Institute, Plovdiv, Bulgaria.
Davidoff
M
M
Popova
L
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007150:Immunohistochemistry; D007985:Leydig Cells / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism*; D020917:Receptor, trkA / Q000378:metabolism*; D012708:Sertoli Cells / Q000378:metabolism
D020800:Receptor, Nerve Growth Factor; D020917:Receptor, trkA