Study of load capacity of Avicel PH-200 and Cellactose, two direct compression excipients, using experimental design.
The load capacity of two excipients, a large particle size grade of microcrystalline cellulose (Avicel PH-200) and a coprocessed material composed of lactose and pulverized cellulose (Cellactose) was determined using a model mix with Dipyrone (metamizol sodium) and experiments planned by design of experiments. A multiple-regression model was proposed, and as a result, a new parameter, called specific load capacity SLC was obtained. This constant can be determined for other excipients and drugs; it depends only on the excipient and the drug used.
Estrada Flores
L
L
Sanofi Synthélabo S. A. de C. V., Cuautitlán, Mexico.
Lopez Arellano
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R
Díaz Esquivel
J J
JJ
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry*; D004177:Dipyrone / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D010316:Particle Size; D012016:Reference Values; D012044:Regression Analysis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D004177:Dipyrone; D002482:Cellulose; D007785:Lactose