Synphilin-1 is present in Lewy bodies in Parkinson's disease.
Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.
Wakabayashi
K
K
Brain Disease Research Center, Brain Research Institute, Niigata University, Japan.
Engelender
S
S
Yoshimoto
M
M
Tsuji
S
S
Ross
C A
CA
Takahashi
H
H
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000906:Antibodies; D015153:Blotting, Western; D002352:Carrier Proteins / Q000032:analysis* / Q000276:immunology; D006801:Humans; D016631:Lewy Bodies / Q000737:chemistry* / Q000473:pathology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000276:immunology; D009474:Neurons / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D011817:Rabbits; D013378:Substantia Nigra / Q000473:pathology; D051843:Synucleins; D051844:alpha-Synuclein
D000906:Antibodies; D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; C118958:SNCAIP protein, human; D051843:Synucleins; D051844:alpha-Synuclein