Increased levels of soluble Fas ligand in serum in Plasmodium falciparum malaria.
Levels of soluble Fas ligand (sFasL) in serum were elevated in patients with Plasmodium falciparum malaria and showed a significant decline during disease course. sFasL levels that were elevated before antimalarial treatment began correlated significantly with depressed total lymphocyte and T-cell counts. These data suggest that Fas-induced apoptosis might play a role in malaria-associated lymphopenia.
Kern
P
P
Section of Infectious Diseases and Clinical Immunology, University of Ulm, Ulm, Germany. peter.kern@medizin.uni-ulm.de
Dietrich
M
M
Hemmer
C
C
Wellinghausen
N
N
D000293:Adolescent; D000328:Adult; D000818:Animals; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000276:immunology; D012995:Solubility
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins