Primary esophageal lymphoepithelioma.
Lymphoepitheliomas are extremely rare outside the nasopharynx. Extranasopharyngeal lymphoepithellomas may be located in the stomach or digestive tract, and only one single case of esophageal location has been found in our review. In many cases the tumor is related to Epstein-Barr virus infection. We report a case of undifferentiated carcinoma of the distal third of the esophagus in a 79 year-old man. Pathological examination of the esophagus revealed an undifferentiated carcinoma with lymphold stroma (lymphoepithelioma). In situ hybridization of the neoplastic cells was negative for Epstein-Barr virus. To our knowledge, the present case is the first documented esophageal lymphoepithelioma in Western countries.
Parra
P
P
Department of General and Digestive Surgery, Hospital Universitario Virgen de Valme, Seville, Spain.
Aguilar
J
J
López-Garrido
J
J
Meléndez
B
B
Merino
E
E
Martinez
Gordillo
E
E
Roldán
J P
JP
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male