The effect of myo-inositol on ethanol-induced metabolic changes and insulin concentration in the rat.
Myo-inositol was found to possess several beneficial effects on the organism. The effect of myo-inositol on ethanol-induced metabolic changes and insulin concentration was investigated in growing rats. The increase in liver triglycerides induced by ethanol drinking (10% ethanol solution as the only drinking fluid for 10 days) was completely abolished by simultaneous treatment with myo-inositol (0. 1 g/100 g b.w., every day given intragastrically). The ethanol-evoked decrease in blood insulin and the increase in liver glycogen were also partially prevented by myo-inositol. Myo-inositol did not cause any undesirable metabolic changes in the rats. The results indicate that myo-inositol may be useful in the treatment of some metabolic consequences of alcohol drinking.
Szkudelski
T
T
Department of Animal Physiology and Biochemistry, University of Agriculture, Poznań, 60-637, Poland. tszkudel@jay.aupoznan.pl
Kandulska
K
K
D000428:Alcohol Drinking / Q000378:metabolism; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D007294:Inositol / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000378:metabolism
D007328:Insulin; D014280:Triglycerides; D000431:Ethanol; D007294:Inositol; D002784:Cholesterol; D005947:Glucose