title: Prevention of air leakage by spraying vivostat fibrin sealant after lung resection in pigs.
abstract: OBJECTIVE
  To evaluate Vivostat fibrin sealant in the prevention of air leakage after experimental lung resection in pigs.
  
  
  METHODS
  Randomized study.
  
  
  METHODS
  University laboratory.
  
  
  METHODS
  Six Landrace pigs were operated on in both lungs through a median sternotomy. Five different resection sites were created in each lung.
  
  
  METHODS
  Randomization was performed to either application of Vivostat fibrin sealant (ConvaTec; Skillman NJ) or human albumin 20% (control) at the resection sites. The lung parenchyma was occluded with a soft clamp for either 1, 2, 5, or 10 min in the treatment group and 10 min in the control group. After removal of the clamp, the lung was ventilated with an increasing intrabronchial pressure of 20, 30, and 45 cm H(2)O for 2 min at each step.
  
  
  RESULTS
  At inspiratory pressures of 20 and 30 cm H(2)O air leaks were found in the control group but not in the Vivostat group (p < 0.001). At an inspiratory pressure of 45 cm H(2)O, there were two small air leaks in the Vivostat group at each clamping time (four at 5 min), compared with five small and seven large leaks in the control group. Analysis of the data after 10 min of clamping showed that the Vivostat group was superior to the human albumin group (p = 0.002).
  
  
  CONCLUSIONS
  This randomized study shows that Vivostat fibrin sealant is effective in preventing air leakage after small lung resections in pigs, even at high inspiratory pressures.
authors.affiliation: Department of Cardiothoracic Surgery, Gentofte Hospital, University of Copenhagen, Denmark. hekja@gentoftehosp.kbhamt.dk
authors.forename: H K
authors.initials: HK
authors.lastname: Kjaergard
authors.forename: J H
authors.initials: JH
authors.lastname: Pedersen
authors.forename: M
authors.initials: M
authors.lastname: Krasnik
authors.forename: U S
authors.initials: US
authors.lastname: Weis-Fogh
authors.forename: H
authors.initials: H
authors.lastname: Fleron
authors.forename: H E
authors.initials: HE
authors.lastname: Griffin
mesh_terms: D000399:Air Pressure; D000818:Animals; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D011013:Pneumonectomy / Q000295:instrumentation; D011030:Pneumothorax / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011897:Random Allocation; D013552:Swine; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives