Steroid-induced osteoporosis in systemic lupus erythematosus.
The patient with SLE is at considerable risk of osteoporosis, because of the inflammatory disease itself, its consequences, and its treatments. Because of their extensive use, glucocorticoids are thought to be the most frequent cause of drug-related osteoporosis and may be responsible for much of the bone loss in lupus. This article focuses on the mechanisms of steroid-induced osteoporosis in SLE and outlines strategies for prevention and treatment.
Cunnane
G
G
Division of Rheumatology, University of California, San Francisco, USA.
Lane
N E
NE
D002118:Calcium / Q000627:therapeutic use; D005938:Glucocorticoids / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D010024:Osteoporosis / Q000139:chemically induced* / Q000517:prevention & control / Q000628:therapy; D012307:Risk Factors; D014807:Vitamin D / Q000627:therapeutic use
D005938:Glucocorticoids; D014807:Vitamin D; D002118:Calcium