Long-term intravenous perinatal cocaine exposure on the mortality of rat offspring.
To examine the effects of chronic perinatal cocaine exposure, cocaine was administered intravenously throughout pregnancy and the postpartum period to the rat. Pregnant rats were divided into five groups: nontreated (naive); normal saline control (saline); cocaine first generation (cocaine); saline in the first generation and cocaine in the second generation (Sal-2G); and cocaine in both first and second generations (Coc-2G). The rats receiving cocaine in the second generation (Sal-2G and Coc-2G) were offspring of the saline and cocaine group, respectively. All cocaine-treated groups received cocaine 2 mg/kg/day intravenously (IV), and the saline group received normal saline 0.2 ml/day IV from GD 2 to the 21st day postpartum. Mean perinatal mortality was greater in all pups exposed to cocaine in utero during gestation; Cocaine (6.4%); Sal-2G (5.6%); Coc-2G (11.4%) groups than in the noncocaine groups (3.2%, 1.3%). Weight gain, physical, and neurological developments of the offspring were not affected. It was concluded that perinatal cocaine exposure had an increased perinatal mortality even at doses approximately 10 times lower than those previously reported, which were administered by extravascular routes. These findings indicate the importance of the route of drug administration in perinatal cocaine research.
Iso
A
A
Departments of Anesthesiology and Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
Nakahara
K
K
Barr
G A
GA
Cooper
T B
TB
Morishima
H O
HO
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning; D001724:Birth Weight; D003042:Cocaine / Q000008:administration & dosage* / Q000633:toxicity; D019970:Cocaine-Related Disorders; D003643:Death; D005260:Female; D005313:Fetal Death; D007275:Injections, Intravenous; D009043:Motor Activity; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012018:Reflex / Q000187:drug effects / Q000502:physiology*; D014886:Weaning
D003042:Cocaine