[Role of cyclic nucleotides in formation of pathologic reactions in the immediate postoperative period].
Effects of anesthesia and surgery on the level of cyclic nucleotides (CN) and their role in the formation of pathological reactions are little studied. We measured plasma concentrations of CN for evaluating the quantitative and qualitative changes in adenylate-guanylate cyclase metabolism under the effect of operation and for elucidating the role of these changes in postoperative disorders of hemodynamics and gas exchange. The findings in patients with surgical diseases of the lungs (168 pts), with acquired and congenital heart diseases (193 pts), and with atherosclerotic involvement of the aorta (63 pts) were analyzed. The CN system is responsible for the pre-, intra-, and postoperative status of surgical patients, which manifests by a hypermetabolic reaction leading to an increase in the blood concentrations of cAMP and cGMP. At the initial stages this reaction is compensatory, while in the immediate postoperative period CN are involved in the pathological mechanisms leading to hemodynamic disorders.
Nazyrova
L A
LA
Shumilova
I Iu
IIu
Ivanchina
E A
EA
D000262:Adenylyl Cyclases / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D001018:Aortic Diseases / Q000601:surgery; D001161:Arteriosclerosis / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D000242:Cyclic AMP / Q000097:blood; D006152:Cyclic GMP / Q000097:blood; D006162:Guanylate Cyclase / Q000378:metabolism; D006330:Heart Defects, Congenital / Q000601:surgery; D006439:Hemodynamics; D006801:Humans; D008171:Lung Diseases / Q000601:surgery; D008875:Middle Aged; D009712:Nucleotides, Cyclic / Q000097:blood*; D011183:Postoperative Complications / Q000378:metabolism*; D011659:Pulmonary Gas Exchange; D011863:Radioimmunoassay; D013997:Time Factors
D009712:Nucleotides, Cyclic; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D006152:Cyclic GMP