Glucoregulatory responses to intense exercise performed in the postprandial state.
A seven- to eightfold increment in hepatic glucose production (endogenous R(a)) occurs in postabsorptive (PA) intense exercise (IE). A similar response is likely present in the postprandial (PP) state, when most such exercise is performed, because 1) little evidence for increased intestinal absorption of glucose during exercise exists, and 2) intravenous glucose does not prevent it. We investigated IE in 10 PA and 8 PP fit, lean, young males who had exercised for 15 min at >84% maximum O(2) uptake, starting 3 h after a 412-kcal mixed meal. The meal induced a small rise in glycemia with sustained insulin and glucagon increases. Preexercise glucose total R(a) and utilization (R(d)) were equal and approximately 130% of the PA level. Exercise hyperglycemia in PP was delayed and diminished and, in early recovery, was of shorter duration and lesser magnitude (P = 0.042). Peak catecholamine (12- to 16-fold increase) and R(a) (PP: 11.5 +/- 1.4, PA: 13.8 +/- 1.4 mg. kg(-1). min(-1)) responses did not differ, and their responses during exercise were significantly correlated. Exercise glucagon, insulin, and glucagon-to-insulin responses were small or not significant. R(d) reached the same peak (PP: 8.0 +/- 0.6, PA: 9.3 +/- 0.8 mg. kg(-1). min(-1)) but was greater at 20-120 min of recovery in PP (P = 0.001). Therefore, the total R(a) response to IE is preserved despite the possibility of prior PP suppression of endogenous R(a) and is consistent with catecholamine mediation. Post-IE hyperglycemia is reduced in the postprandial state.
Kreisman
S H
SH
McGill Nutrition and Food Science Centre, Montreal, Quebec H3A 1A1, Canada.
Manzon
A
A
Nessim
S J
SJ
Morais
J A
JA
Gougeon
R
R
Fisher
S J
SJ
Vranic
M
M
Marliss
E B
EB
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005502:Food; D005934:Glucagon / Q000097:blood; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007408:Intestinal Absorption; D007700:Kinetics; D019344:Lactic Acid / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption; D019289:Pyruvic Acid / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D019344:Lactic Acid; D019289:Pyruvic Acid; D005934:Glucagon; D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine