title: [Molecular biological and clinical-morphological studies of gastric tumors associated with Epstein-Barr virus].
abstract: The paper presents the results of the studies of gastric cancer (GC) associated with Epstein-Barr virus (EBV) among the patients residing in 4 geographical regions. In situ hybridization (ISH) techniques revealed that 49(11.4%) of the 430 examinees were EBV positive (EBV+), the virus-specific marker mRNA-1 of EBV, EBER-1) was found to be present in 80-100) of tumor cells. The proportion of EBV(+)-associated GC cases in different geographic regions ranged from 7.3 to 15%. These tumors were predominant in males (15%) as opposite to females (5.5%). Histological types most common among EBV+ tumors and their location in the stomach are also described. Serological findings indicated that the increased anti-EDV antibody response in 70% of GC cases coincided with the presence of the viral genetic information detected by ISH. In contrast to a humoral response to EBV, a humoral response to Helicobacter pylori was equal both in patients with EBV(+)- and EBV(-)-associated gastric tumors. Further molecular biological analysis of EBV isolates from virus positive and virus negative GC may answer the question whether there are really the so-called tumor and non-tumor variants of EBV.
authors.forename: V E
authors.initials: VE
authors.lastname: Gurtsevich
authors.forename: E V
authors.initials: EV
authors.lastname: Novikova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Borisova
authors.forename: V N
authors.initials: VN
authors.lastname: Stepina
authors.forename: L S
authors.initials: LS
authors.lastname: Iakovleva
authors.forename: M I
authors.initials: MI
authors.lastname: Davydov
authors.forename: A A
authors.initials: AA
authors.lastname: Klimenkov
authors.forename: S N
authors.initials: SN
authors.lastname: Nered
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
authors.forename: O M
authors.initials: OM
authors.lastname: Kozlovskiĭ
authors.forename: V A
authors.initials: VA
authors.lastname: Britvina
authors.forename: E S
authors.initials: ES
authors.lastname: Petel'nikova
authors.forename: N N
authors.initials: NN
authors.lastname: Petrovichev
authors.forename: R M
authors.initials: RM
authors.lastname: Ruzabakiev
authors.forename: M
authors.initials: M
authors.lastname: Tokunaga
authors.forename: D G
authors.initials: DG
authors.lastname: Zaridze
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009031:Moscow / Q000453:epidemiology; D012333:RNA, Messenger / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors; D012800:Siberia / Q000453:epidemiology; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D012333:RNA, Messenger; D012367:RNA, Viral