title: Interhemispheric effects of simulated lesions in a neural model of single-word reading.
abstract: A neural model consisting of paired cerebral hemispheric regions interacting via homotopic callosal connections was trained to generate pronunciations for 50 monosyllabic words. Lateralization of this task occurred readily when different underlying cortical asymmetries were present. Following simulated focal cortical lesions of systematically varied sizes, acute changes in the distribution of cortical activation were found to be most consistent with experimental data when interhemispheric interactions were assumed to be excitatory. During subsequent recovery, the contribution of the unlesioned hemispheric region to performance improvement was a function of both the amount of preexisting lateralization and the side and size of the lesion. These results are discussed in the context of unresolved issues concerning the mechanisms underlying language lateralization, the nature of interhemispheric interactions, and the role of the nondominant hemisphere in recovery from adult aphasia.
authors.affiliation: Department of Computer Science, Institute for Advanced Computer Studies, University of Maryland, College Park 20742, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Shkuro
authors.forename: M
authors.initials: M
authors.lastname: Glezer
authors.forename: J A
authors.initials: JA
authors.lastname: Reggia
mesh_terms: D007839:Functional Laterality; D006801:Humans; D008962:Models, Theoretical; D016571:Neural Networks, Computer; D011932:Reading