The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis.
In bacteria, extracellular signals are generally transduced into cellular responses via a two-component system. However, genome sequence data have now revealed the presence of 'eukaryotic-like' protein kinases and phosphatases. Mycobacterium tuberculosis appears to be unique among bacteria in that its genome contains 11 members of a newly identified protein kinase family. These M. tuberculosis eukaryotic-like protein kinases could be key regulators of metabolic processes, including transcription, cell development and interactions with host cells.
Av-Gay
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Divn of Infectious Diseases, University of British Columbia, 2733 Heather St, Vancouver, BC, Canada. yossi@interchange.ubc.ca
Everett
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D000595:Amino Acid Sequence; D005057:Eukaryotic Cells / Q000201:enzymology; D015964:Gene Expression Regulation, Bacterial; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D017346:Protein Serine-Threonine Kinases