Telephone-administered cognitive-behavioral therapy for the treatment of depressive symptoms in multiple sclerosis.
This study examined the efficacy of an 8-week telephone-administered cognitive-behavioral therapy (CBT) for the treatment of depressive symptomatology in multiple sclerosis (MS) patients. The treatment, Coping with MS (CMS), included a patient workbook designed to structure the treatment, provide visual aids, and help with homework assignments. Thirty-two patients with MS, who scored at least 15 on the Profile of Mood States Depression-Dejection scale, were randomly assigned to either the telephone CMS or to a usual-care control (UCC) condition. Depressive symptomatology decreased significantly in the CMS condition compared with the UCC condition. Furthermore, adherence to interferon beta-1a, a disease-modifying medication for the treatment of MS, was significantly better at the 4-month follow-up among patients who received CMS as compared with those in the UCC condition.
Mohr
D C
DC
Department of Neurology, University of California, San Francisco (UCSF) 94115-1642, USA. dmohr@itsa.ucsf.edu
Likosky
W
W
Bertagnolli
A
A
Goodkin
D E
DE
Van Der Wende
J
J
Dwyer
P
P
Dick
L P
LP
D000223:Adaptation, Psychological; D000328:Adult; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003863:Depression / Q000523:psychology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000523:psychology*; D010349:Patient Compliance / Q000523:psychology; D010555:Personality Inventory; D012803:Sick Role; D013689:Telephone