Synthesis and DNA-binding of acridine-netropsin hybrid molecules.
We have designed and synthesized acridine-netropsin hybrid molecules. Spectroscopic (absorption, CD, flow dichroism and fluorescence) measurements reveal that hybrid molecules interact with DNA by both intercalation and minor-groove binding and shows enhanced preference for AT-rich sites.
Kubota
Y
Y
Department of Chemistry, Faculty of Science, Yamaguchi University, Japan.
Kawamura
S
S
Uchida
R
R
D000166:Acridines / Q000138:chemical synthesis / Q000737:chemistry*; D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D015195:Drug Design; D015394:Molecular Structure; D009429:Netropsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D013053:Spectrophotometry
D000166:Acridines; D009838:Oligodeoxyribonucleotides; C409969:acridine-netropsin hybrid molecule; D009429:Netropsin; D004247:DNA