Epithelial-mesenchymal interaction in gastric mucosal restoration.
In this review article we discuss the role of growth factors in gastric ulcer healing using an in vitro wound repair model with gastric epithelial and mesenchymal cells. Several growth factors accelerate gastric epithelial and mesenchymal wound healing in vitro with acceleration of cell migration and proliferation. Epidermal growth factor, transforming growth factor-alpha (TGFalpha), hepatocyte growth factor, and insulin accelerate predominantly gastric epithelial wound healing; and TGFbeta and basic fibroblast growth factor predominantly accelerate gastric mesenchymal wound healing. Platelet-derived growth factor-betabeta and insulin-like growth factor-1 (IGF-1) accelerate both significantly. Among these growth factors, IGF-1 produced from fibroblasts plays a key role in the gastric epithelial-mesenchymal interaction during the process of gastric wound healing.
Watanabe
S
S
First Department of Internal Medicine, Akita University School of Medicine, Japan.
Hirose
M
M
Wang
X E
XE
Kobayashi
O
O
Nagahara
A
A
Murai
T
T
Iwazaki
R
R
Miwa
H
H
Miyazaki
A
A
Sato
N
N
D000818:Animals; D004848:Epithelium / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D008648:Mesoderm / Q000473:pathology; D010437:Peptic Ulcer / Q000473:pathology*; D014945:Wound Healing / Q000502:physiology*
D006133:Growth Substances