Solid-phase synthesis of oligomeric deoxynucleic-thiourea (DNT) and deoxynucleic S-methylthiourea (DNmt): a neutral/polycationic analogue of DNA.
A solid-phase synthesis for oligomeric DNmt is reported. Synthesis proceeds in 3'-5' direction and involves coupling of a protected 3'-isothiocyanate with the corresponding 5'-amine of the growing oligo chain. The difference in oligomeric thiourea/S-methylthiourea binding to DNA is investigated.
Arya
D P
DP
Department of Chemistry, University of California, Santa Barbara 93106, USA.
Bruice
T C
TC
D004247:DNA / Q000737:chemistry*; D011073:Polyamines; D000071228:Polyelectrolytes; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D004247:DNA; D011073:Polyamines; D000071228:Polyelectrolytes; D013890:Thiourea