Interleukin-15 and its impact on neutrophil function.
Interleukin-15 is a recently discovered cytokine produced by several cell types (including fibroblasts, keratinocytes, endothelial cells, and macrophages) in response to endotoxin or microbial infection. In turn, interleukin-15 has been shown to act on various cells of the immune system, including T and B lymphocytes, natural killer cells, monocytes, eosinophils, and circulating neutrophils. In the latter instance, interleukin-15 was initially observed to induce cytoskeletal rearrangements, to enhance phagocytosis, to increase the synthesis of several cellular proteins, and to delay apoptosis. Recently, interleukin-15 has been found to elicit other functional responses in neutrophils, such as chemokine production. This review recapitulates advances made in the area of interleukin-15/neutrophil interactions.
Cassatella
M A
MA
Department of Pathology, University of Verona, Italy. MCNCSS@borgoroma.univr.it
McDonald
P P
PP
D000818:Animals; D006801:Humans; D007249:Inflammation; D019409:Interleukin-15 / Q000097:blood / Q000494:pharmacology* / Q000502:physiology; D018375:Neutrophil Activation / Q000187:drug effects / Q000235:genetics; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D019409:Interleukin-15