Presumed parvovirus B19-associated retinal pigment epitheliopathy.
OBJECTIVE
To describe a patient with a white dot syndrome associated with acute erythema infectiosum.


METHODS
A patient with a clinical history of erythema infectiosum and multifocal punctate white lesions at the level of the retinal pigment epithelium was followed up for an 8-month interval. Serum was tested for immunoglobulin M (IgM) and IgG antibodies to parvovirus B19 at the time of the initial evaluation and during convalescence using an indirect immunofluorescence antibody technique. Serial photographs and fluorescein angiograms were obtained.


RESULTS
IgM and IgG antibodies to parvovirus were detected in the serum at the time of initial evaluation; IgM antibodies had disappeared but IgG antibodies persisted in serum obtained at 1-month follow-up. Fundus evaluation revealed clinical disappearance of some lesions, with increased pigmentation of others over the course of follow-up.


CONCLUSIONS
The authors have identified an adult patient who presented with a white dot syndrome associated with acute erythema infectiosum documented by serologically proved parvovirus B19 infection.
Grand
M G
MG
Barnes Retina Institute, Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Storch
G A
GA
D000208:Acute Disease; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D015828:Eye Infections, Viral / Q000175:diagnosis / Q000209:etiology* / Q000821:virology; D005260:Female; D005451:Fluorescein Angiography; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D016732:Parvovirus B19, Human / Q000276:immunology / Q000302:isolation & purification*; D010857:Pigment Epithelium of Eye / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology* / Q000821:virology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M