Hepatoprotective activity of ellagic acid against carbon tetrachloride induced hepatotoxicity in rats.
Administration of CCl4 to normal rats and consequent oral feeding with ellagic acid (50 mg/kg) provided a significant protection against the biochemical alterations in serum and liver produced by CCl4. In vitro experiments showed that liver microsomes from animals treated with ellagic acid and CCl4, decreased lipid peroxidation compared to microsome prepared from rats exposed to CCl4 alone.
Singh
K
K
Biochemistry Division, Central Drug Research Institute, Lucknow, India.
Khanna
A K
AK
Chander
R
R
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002251:Carbon Tetrachloride / Q000633:toxicity; D004610:Ellagic Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats
D000975:Antioxidants; D004610:Ellagic Acid; D002251:Carbon Tetrachloride