title: Adenomyosis: symptoms, histology, and pregnancy terminations.
abstract: OBJECTIVE
  To correlate symptoms of uterine adenomyosis with histopathologic features.
  
  
  METHODS
  One hundred eleven specimens of uteri and cervices that weighed under 280 g were reevaluated. When adenomyosis was identified, assessment included depth of adenomyotic foci, graded as deep (above 80%), intermediate (40-80%), and superficial (under 40%), and number of adenomyotic foci. Clinical data were collected from patient records.
  
  
  RESULTS
  Specimens were categorized in four groups, 17 with adenomyosis alone, 19 with adenomyosis with leiomyomas, 39 with leiomyomas alone, and 36 with neither. Among women with adenomyosis alone, 58.8% had pregnancy terminations and 47.4% of women with adenomyosis and leiomyomas had terminations, compared with 20.5% of women with leiomyomas alone (P <.01) and 22.2% in those with neither (P <.01). The number of foci correlated significantly with depth within the myometrium in specimens with adenomyosis alone (r =.46, P =.05) or combined with leiomyomas (r =.66, P <.001). The median number of foci associated with dysmenorrhea was 10 compared with 4.5 without it (P <.003); in menorrhagia the respective median numbers were 7 and 7 (P =.25). Menorrhagia and dysmenorrhea presented in 36.8% and 77.8% of deep, compared with 13.3% (P <.001) and 12.5% (P <.001) of intermediate depths, respectively. Superficial depth was not associated with menorrhagia or dysmenorrhea.
  
  
  CONCLUSIONS
  Pregnancy termination might affect the pathogenesis of adenomyosis. The number of foci and their myometrial depths correlated to each other and to dysmenorrhea, but only myometrial depth correlated to menorrhagia.
authors.affiliation: Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York 11219, USA. michaellevgur@pol.net
authors.forename: M
authors.initials: M
authors.lastname: Levgur
authors.forename: M A
authors.initials: MA
authors.lastname: Abadi
authors.forename: A
authors.initials: A
authors.lastname: Tucker
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000022:Abortion, Spontaneous / Q000150:complications*; D004715:Endometriosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000453:epidemiology / Q000209:etiology*; D016015:Logistic Models; D008595:Menorrhagia; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology; D009515:New Jersey / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D012189:Retrospective Studies; D014591:Uterine Diseases / Q000453:epidemiology / Q000209:etiology*; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000209:etiology