Neuronal and inducible nitric oxide synthase distribution in retinas of microphthalmic mice.
A study about the distribution of neuronal nitric oxide synthase (n-NOS) and inducible NOS (i-NOS) was performed in microphthalmic retinas at postnatal day (pd) 2 and pd 7. Neither n-NOS nor i-NOS immunoresponse could be detected at pd 2. At pd 7, i-NOS activity was revealed in the retinas of mi/mi littermates but not in those of heterozygotes or wild-type littermates. The expression of n-NOS corresponded to the postnatal retinal development. Retinal rosettes were strongly labelled.
Hilbig
H
H
Institute of Anatomy, University of Leipzig, Germany.
Ernstberger
J
J
Lenk
C
C
D000818:Animals; D004790:Enzyme Induction; D051379:Mice; D008850:Microphthalmos / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; D012160:Retina / Q000201:enzymology* / Q000254:growth & development
D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; D052247:Nitric Oxide Synthase Type II; C496321:Nos1 protein, mouse; C496317:Nos2 protein, mouse