Type III machines of Gram-negative bacteria: delivering the goods.
Many Gram-negative pathogens use a type III secretion machine to translocate protein toxins across the bacterial cell envelope. Pathogenic Yersinia spp. export at least 14 Yop proteins via a type III machine, which recognizes secretion substrates by signals encoded in yop mRNA or chaperones bound to unfolded Yop proteins. During infection, substrate recognition appears to be regulated in a manner that allows the Yersinia type III pathway to direct Yops to the bacterial envelope, the extracellular medium or into the cytosol of host cells.
Cheng
L W
LW
Dept of Microbiology and Immunology, UCLA School of Medicine, Los Angeles, CA 90095, USA.
Schneewind
O
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D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D005057:Eukaryotic Cells / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D015007:Yersinia / Q000378:metabolism / Q000472:pathogenicity
D001425:Bacterial Outer Membrane Proteins; D018832:Molecular Chaperones