Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors.
A series of 2'-heterocyclic derivatives of 5-phenyl-2,5'-1H-bibenzimidazoles were evaluated for topoisomerase I poisoning activity and cytotoxicity. Topo I poisoning activity was associated with 2'-derivatives that possessed a hydrogen atom capable of hydrogen bond formation, suggesting that the interatomic distances between such hydrogen atoms and the heteroatoms on the adjacent benzimidazole influence activity.
Jin
S
S
Department of Pharmaceutical Chemistry, Rutgers, The State University of Nerw Jersey, Piscataway 08854-8020, USA.
Kim
J S
JS
Sim
S P
SP
Liu
A
A
Pilch
D S
DS
Liu
L F
LF
LaVoie
E J
EJ
D001562:Benzimidazoles / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D013057:Spectrum Analysis; D059004:Topoisomerase I Inhibitors
D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D059004:Topoisomerase I Inhibitors