title: Scalarane and homoscalarane compounds from the nudibranchs Glossodoris sedna and Glossodoris dalli: chemical and biological properties.
abstract: A series of homoscalarane and scalarane compounds (2-7) have been isolated from two distinct species of Pacific Glossodoris nudibranchs. The structure and elucidation of the relative stereochemistry of the new metabolites 2 and 3 were obtained by spectroscopic methods. Compound 2 was ichthyotoxic at 0.1 ppm against Gambusia affinis and showed moderate activity (IC(50) 18 microM) to inhibit mammalian phospholipase A(2).
authors.affiliation: Istituto per la Chimica di Molecole di Interesse Biologico (ICMIB)(1) del CNR, via Toiano 6, 80072 Arco Felice, Napoli, Italy. a.fontana@icmib.na.cnr.it
authors.forename: A
authors.initials: A
authors.lastname: Fontana
authors.forename: E
authors.initials: E
authors.lastname: Mollo
authors.forename: J
authors.initials: J
authors.lastname: Ortea
authors.forename: M
authors.initials: M
authors.lastname: Gavagnin
authors.forename: G
authors.initials: G
authors.lastname: Cimino
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D005399:Fishes; D009682:Magnetic Resonance Spectroscopy; D008974:Mollusca / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013261:Sterols / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D014020:Tissue Extracts / Q000737:chemistry
chemical_list: C409626:12-deacetyl-23-acetoxy-20-methylscalaradial; D013261:Sterols; D014020:Tissue Extracts