title: Adenocarcinoma of the stomach with tumor-thrombotic microangiopathy in an 11-year-old male patient.
abstract: The majority of malignancies in childhood are represented by leukemias, lymphomas or other reticuloendothelial neoplasms, tumors of the central nervous system, nephroblastomas and sarcomas. Gastrointestinal tumors represent less than 5% of pediatric neoplasms and carcinomas within this subgroup have been very rarely described, especially those arising in the stomach. In this study, we report a case of an 11-year-old boy with a signet-ring carcinoma of the stomach. The patient initially presented with respiratory symptoms which were caused by massive pulmonary lymphangiosis carcinomatosa and a peculiar microangiopathy, recently addressed as pulmonary tumor thrombotic microangiopathy. To our knowledge, this constellation has not been reported so far.
authors.affiliation: Department of Pathology, University of Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Bläker
authors.forename: R
authors.initials: R
authors.lastname: Daum
authors.forename: J
authors.initials: J
authors.lastname: Tröger
authors.forename: G
authors.initials: G
authors.lastname: Mechtersheimer
authors.forename: H F
authors.initials: HF
authors.lastname: Otto
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000150:complications*; D002648:Child; D006801:Humans; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D013274:Stomach Neoplasms / Q000150:complications*; D013927:Thrombosis / Q000150:complications*; D014057:Tomography, X-Ray Computed