[p53 and steroid receptors support double endometrial carcinogenesis].
OBJECTIVE
This study investigated the p53 positivity correlated with the receptor status, in different grades and stages of endometrial carcinoma.


METHODS
The study included 88 endometrioid-type carcinomas and 5 non-endometrioid-type carcinomas. Paraffin sections were used for the ordinary histological diagnosis and for immunohistochemical diagnosis by avidin-biotin-peroxidase technique.


RESULTS
p53 positivity was identified in 10 endometrioid-type carcinomas (11.4%) and 3 non-endometrioid type carcinomas (60%). Most of the p53 positive cases were receptor negative and observed in advanced stages and histological grades. No associated endometrial hyperplasia was p53 positive, while a positive intraepithelial non-endometrioid carcinoma was identified.


CONCLUSIONS
p53 positivity is most frequently identified in non-endometrioid type, receptor negative adenocarcinomas, even in a precursor lesion as it is intraepithelial carcinoma, while in endometrioid, receptor positive carcinomas it appear in late stages of development, never being identified in precursor lesions.
Teleman
S
S
Disciplina de Morfopatologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Mihailovici
M S
MS
Hilgarth
M
M
Freudenberg
N
N
Bettendorf
H
H
D002277:Carcinoma / Q000209:etiology / Q000378:metabolism*; D018269:Carcinoma, Endometrioid / Q000209:etiology / Q000378:metabolism*; D004714:Endometrial Hyperplasia / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000209:etiology / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000209:etiology / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D011987:Receptors, Steroid; D016159:Tumor Suppressor Protein p53