title: [An immunohistochemical study of the steroid hormone receptors in endometrial hyperplasia].
abstract: OBJECTIVE
  Evaluation of the estrogen and progesterone receptors (ER and PR) in different degrees of endometrial hyperplasias.
  
  
  METHODS
  10 cases of each degree of endometrial hyperplasia (simple, complex and atypical) were analyzed using the avidin-biotin-peroxidase technique and monoclonal antibodies applied to formalin-fixed, paraffin-embedded tissue.
  
  
  RESULTS
  We found similar, high level of both ER and PR in simple and complex hyperplasias and a significant decrease of these in atypical hyperplasia.
  
  
  CONCLUSIONS
  Endometrial hyperplasias develop in a setting of estrogen excess. This explains the high level of endometrial receptors and the response to progesterone in typical hyperplasia. In atypical hyperplasia, the decrease of steroid receptors results in a low sensibility of this lesion to progestative therapy, but there are cases with high receptor levels which could have a chance for hormonal therapy.
authors.affiliation: Disciplina Morfopatologie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: S
authors.initials: S
authors.lastname: Teleman
authors.forename: M
authors.initials: M
authors.lastname: Hilgarth
authors.forename: N
authors.initials: N
authors.lastname: Freudenberg
authors.forename: H
authors.initials: H
authors.lastname: Bettendorf
authors.forename: M S
authors.initials: MS
authors.lastname: Mihailovici
mesh_terms: D015415:Biomarkers; D004714:Endometrial Hyperplasia / Q000145:classification / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone