Inflammation-coagulation network: are serine protease receptors the knot?
Following an injury, the body recruits a mechanism to delimit and repair tissue damage; this phenomenon is known as inflammation. Among the several different pathways that are activated during this process, which is necessary for survival, activation of the coagulation pathway is a key feature. In fact, clinical changes in blood fluidity have been closely related to ongoing inflammation. Recent evidence suggests that serine protease receptors might play a major role in the host defence mechanism at the interface between coagulation and inflammation.
Cirino
G
G
Dipartimento di Farmacologia Sperimentale, Federico II University of Naples, Via Domenico Montesano 49, 80131 Napoli, Italy. cirino@unina.it
Napoli
C
C
Bucci
M
M
Cicala
C
C
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin / Q000235:genetics / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000737:chemistry / Q000378:metabolism*
D044463:Receptor, PAR-1; D044464:Receptor, PAR-2; D018179:Receptors, Thrombin; D012697:Serine Endopeptidases