title: Effect of ischemia and cooling on the response to high frequency stimulation in rat tail nerves.
abstract: In normal rat tail nerves the effect of temperature and ischemia on the response to long-term high frequency stimulation (HFS) (143 Hz) was studied. The effect of temperature was studied in two consecutive tests at 14 degrees C and 35 degrees C. Prior to the HFS the peak-to-peak amplitude (PP-amp) of the compound nerve action potential was 139 +/- 20 microV (mean +/- SD) and 127 +/- 37 microV at 35 degrees C and 14 degrees C, respectively (NS). After 15 min of HFS the PP-amp was reduced to 45.3 +/- 20.5% of baseline level at 14 degrees C as compared with 80.8 +/- 10.2% at 35 degrees C (p < 0.001). Applying ischemia to the rat tail, an additional fall of the PP-amp was seen after 15-20 min of HFS at both low (20 Hz) and high (143 Hz) stimulation frequencies. In conclusion, ischemia and cooling result in an impaired ability to transmit high frequency impulses.
authors.affiliation: Department of Clinical Neurophysiology, Aarhus University Hospital, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Andersen
authors.forename: J F
authors.initials: JF
authors.lastname: Nielsen
authors.forename: B
authors.initials: B
authors.lastname: Sørensen
authors.forename: V K
authors.initials: VK
authors.lastname: Nielsen
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D003080:Cold Temperature; D004558:Electric Stimulation; D004566:Electrodes; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D010525:Peripheral Nerves / Q000098:blood supply / Q000201:enzymology / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013623:Tail / Q000098:blood supply / Q000294:innervation*
chemical_list: D000254:Sodium-Potassium-Exchanging ATPase