Tec family kinases in lymphocyte signaling and function.
The Tec kinases are required for full Ca(2+) mobilization in lymphocytes. Recent data suggest that this process occurs via a multiprotein complex that includes LAT and SLP-76 in T cells and BLNK/SLP-65 in B cells. Mutational analyses have revealed critical roles for Tec kinases in lymphocyte development and function.
Schaeffer
E M
EM
Department of Pathology, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. USA, USA. tschaeffer@uchichago.edu.
Schwartzberg
P L
PL
D001402:B-Lymphocytes / Q000276:immunology; D004789:Enzyme Activation; D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011946:Receptors, Antigen / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D011946:Receptors, Antigen; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases