[Reactivity of blood vessels: the role of mechanical stimulation and initial tone].
We have studied hemodynamic and some other correlates of the myogenic and endothelium-dependent control of vessel tone and reactivity in experiments with anesthetized cats and rats, as well as in vitro experiments with isolated segments of the mesenteric and tail artery of the rats. We present evidence for the important role of mechanical stimulation of endotheliocytes in the formation of vasodilation in skeletal muscles in response to increased amplitude of the pulse pressure, as well as in response to their active or passive contractions. Interference between mechanical, neurohumoral, and metabolic effects on vascular tone were studied. In spontaneously hypertensive rats, endothelium-dependent vasodilation initiated by increased oscillations of pulse pressure is diminished. We also describe relationships between systemic hemodynamic responses and the initial arterial tone.
Dvoretskiĭ
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DP
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Osadchiĭ
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LI
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D002415:Cats; D004730:Endothelium, Vascular / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D066298:In Vitro Techniques; D008638:Mesenteric Arteries / Q000502:physiology; D009119:Muscle Contraction; D009129:Muscle Tonus / Q000502:physiology*; D018482:Muscle, Skeletal / Q000098:blood supply; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar; D013045:Species Specificity; D013314:Stress, Mechanical; D013623:Tail / Q000098:blood supply; D014664:Vasodilation / Q000502:physiology