Alternating current aspects of antimicrobial molecular complexes.
A novel method was designed involving the titration of alternating current titration in a cell where one electrode was shielded by a capillary enclosure restricting access to it by charge carriers. With this cell, charge transfer complex titration of several thiazines all with some antimicrobial properties was effected in acetonitrile, against the electron accepting molecule iodine. The maxima of the Job plots generated by these titrations exhibited displacement of their positions for the forward and reverse titrations with respect to electron donor-acceptor complexation conductivity and apparent stoichiometry. A plot of inverse conductivity maxima differences against literature-cited dipole moments squared yielded a straight line passing through the origin. The titration plot profiles are discussed in terms of the type, number, and mobility of charge carriers produced in the complexation interaction. This novel method may be used to determine dipole moments of bioactive homologues empirically. There was correlation between thiazine drug dipole moments and minimal inhibitory concentrations of these drugs for some bacterial and yeast species. Several new avenues of investigation of possible relevance to microbiology are suggested.
Keyzer
H
H
Department of Chemistry and Biochemistry, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA. hendrik21@jps.net
Kim
H K
HK
Pan
K C
KC
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D014150:Antipsychotic Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D003217:Conductometry / Q000295:instrumentation / Q000379:methods*; D004553:Electric Conductivity; D008826:Microbial Sensitivity Tests; D010640:Phenothiazines / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D014150:Antipsychotic Agents; D010640:Phenothiazines; D002746:Chlorpromazine