Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.
Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.
Brzustowicz
L M
LM
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA. brzustowicz@axon.rutgers.edu
Hodgkinson
K A
KA
Chow
E W
EW
Honer
W G
WG
Bassett
A S
AS
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D003198:Computer Simulation; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers