title: Association between type 1 diabetes age-at-onset and intercellular adhesion molecule-1 (ICAM-1) gene polymorphism.
abstract: We investigated the intercellular adhesion molecule-1 (ICAM-1) gene polymorphism in 90 patients with young-onset type 1 diabetes, 74 with adult-onset type 1 diabetes, and 171 control subjects. The distribution of C-T genotypes and allele frequencies in exon 6 of the ICAM-1 gene was significantly different between adult-onset type 1 diabetes patients and controls (chi(2) = 9.76, p = 0.0076), and between patients with adult-onset and young-onset type 1 diabetes (chi(2) = 11.28, p = 0.0036). In contrast, we failed to detect any association between patients with young-onset type 1 diabetes and controls. Our data suggest that ICAM-1 exon 6 gene polymorphism affects the age-at-onset of type 1 diabetes and that different pathogenetic mechanisms may exist between young-onset and adult-onset type 1 diabetes.
authors.affiliation: Department of Neurology and Clinical Research Center, Utano National Hospital, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Obayashi
authors.forename: E
authors.initials: E
authors.lastname: Maruya
authors.forename: M
authors.initials: M
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Tegoshi
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: G
authors.initials: G
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Shigeta
authors.forename: Y
authors.initials: Y
authors.lastname: Kitagawa
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: H
authors.initials: H
authors.lastname: Saji
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology* / Q000235:genetics*; D005091:Exons; D005787:Gene Frequency; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D007564:Japan; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D018799:Intercellular Adhesion Molecule-1