title: Mortality of parents of children with cancer: a population-based study in Turin, Italy.
abstract: OBJECTIVE
  A cohort study was conducted in order to measure cause-specific mortality among parents of children recorded in the Childhood Cancer Registry of Piedmont. It is the first study carried out on the subject in southern Europe.
  
  
  METHODS
  The study comprised the 740 children resident in Turin and in whom a cancer had been diagnosed in the period 1967-1991. Nominal data were obtained for 723 fathers and 733 mothers. At the end of the follow-up in 1995, 645 fathers were alive, 68 dead and 10 untraceable. Corresponding figures for mothers were 700, 28 and 5. Cause of death was known for 91 of 96 parents.
  
  
  RESULTS
  The period of observation of parents started on the birth of the index child, however mortality analyses were restricted to the period after 1965 because of limited availability of local reference rates. Total mortality was lower than expected among fathers (66 observed deaths vs 88.2 expected, P <0.05) and mothers (28 vs 31.4). Fathers showed deficits (not statistically significant) of lung neoplasms (4 vs 9.9), cardiovascular diseases (18 vs 27.1) and hepatic cirrhosis (2 vs 6.6). No statistically significant variations in mortality were observed with time from diagnosis or according to life status of the children. No cancer deaths occurred among the mothers of sarcoma cases whereas 1.9 were expected.
  
  
  CONCLUSIONS
  The data do not indicate any increase in mortality from cancer or other causes end, on the contrary, show a reduction in mortality which was more evident for the causes related to life style.
authors.affiliation: Childhood Cancer Registry of Piedmont, Center for Cancer Prevention (CPO-Piedmont), San Giovanni Battista Hospital and University, Turin, Italy.
authors.forename: M L
authors.initials: ML
authors.lastname: Mosso
authors.forename: C
authors.initials: C
authors.lastname: Magnani
authors.forename: G
authors.initials: G
authors.lastname: Pastore
authors.forename: B
authors.initials: B
authors.lastname: Terracini
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009369:Neoplasms / Q000235:genetics / Q000401:mortality; D010290:Parents; D012042:Registries