title: [Aspirin: allergy or intolerance].
abstract: OBJECTIVE
  The paper describes the clinical characteristics of patients with aspirin-induced asthma and/or urticaria, angioedema, shock, the results of the challenge tests and the evolution of this disease.
  The authors present the different arguments supporting the physiopathological mechanisms from genetics to the inhibition of cyclooxugenase or the leukotriene hypothesis.
  
  
  CONCLUSIONS
  Finally, they recall the methodology to be used for a good clinical practice on this controversial field of research.
authors.affiliation: Service de médecine interne IV, centre d'allergie de l'Ouest parisien, hôpital Louis-Mourier, Colombes, France.
authors.forename: A
authors.initials: A
authors.lastname: Pradalier
authors.forename: D
authors.initials: D
authors.lastname: Vincent
mesh_terms: D000799:Angioedema / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D005343:Fibrinolytic Agents / Q000009:adverse effects*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012106:Research; D014581:Urticaria / Q000139:chemically induced
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin