Radicals and oxidative stress in diabetes.
Recent evidence is reviewed indicating increased oxidative damage in Type 1 and Type 2 diabetes mellitus as well as deficits in antioxidant defence enzymes and vitamins. Mechanisms are considered whereby hyperglycaemia can increase oxidative stress, and change the redox potential of glutathione and whereby reactive oxygen species can cause hyperglycaemia. It is argued that oxygen, antioxidant defences, and cellular redox status should now be regarded as central players in diabetes and the metabolic syndrome.
West
I C
IC
Department of Biochemistry and Genetics, University of Newcastle upon Tyne, UK. i.c.west@ncl.ac.uk
D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D005609:Free Radicals; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
D005609:Free Radicals; D017382:Reactive Oxygen Species