title: The impact of chronic diseases on the health-related quality of life (HRQOL) of Chinese patients in primary care.
abstract: BACKGROUND
  Ageing of the population results in an increasing number of people living with chronic diseases that can adversely affect their quality of life. Information on the impact of chronic diseases on quality of life can make health services more patient-centred.
  
  
  OBJECTIVE
  The aim of this study was to determine the impact of eight chronic diseases on the health-related quality of life (HRQOL) of Chinese patients.
  
  
  METHODS
  A cross-sectional case-control study was carried out on 760 adult Chinese patients of a family medicine clinic in Hong Kong. Each subject answered the COOP/WONCA charts and a standard questionnaire on demographic and morbidity data. The likelihood of sub-optimal COOP/WONCA scores of each disease group was compared with that of patients without any of the surveyed diseases. The independent effects of each disease on the COOP/WONCA scores were analysed by multivariate logistic regression, controlling for demographic variables and co-morbidity.
  
  
  RESULTS
  Depression increased the risks for sub-optimal scores in all but one COOP/WONCA chart with odds ratios (OR) ranging from 2.1818 to 3.8645. Hypertension increased the risk of a sub-optimal physical fitness score (OR 1.7263). Increased risk of limitations in daily activities was associated with stroke (OR = 1.8771), osteoarthritis of the knee (OR = 1.5867), diseases of joints other than the knees (OR 2.0187) and asthma/COPD (OR 2.1679). Osteoarthritis of the knees also increased the risk of sub-optimal overall health (OR = 1.7927).
  
  
  CONCLUSIONS
  Depression was the most disabling disease, and osteoarthritis of the knee had more impact on the HRQOL than many other chronic diseases. The lack of adverse effects of diabetes mellitus and heart disease on the HRQOL of Chinese patients deserves further studies.
authors.affiliation: Family Medicine Unit, Department of Medicine and Department of Statistics, University of Hong Kong, Hong Kong.
authors.forename: C L
authors.initials: CL
authors.lastname: Lam
authors.forename: I J
authors.initials: IJ
authors.lastname: Lauder
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease / Q000453:epidemiology / Q000523:psychology*; D003430:Cross-Sectional Studies; D005194:Family Practice; D005260:Female; D015577:Geriatric Assessment; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D015999:Multivariate Analysis; D011320:Primary Health Care; D011788:Quality of Life; D012307:Risk Factors; D011795:Surveys and Questionnaires