title: Chest pain and gastroesophageal reflux disease.
abstract: Gastroesophageal reflux disease (GERD) is the most common gastrointestinal cause of "noncardiac chest pain." Following exclusion of a cardiac cause of chest pain, an evaluation of the esophagus is, therefore, appropriate. Barium studies, endoscopy, and esophageal manometry have little value in the diagnosis of GERD-induced chest pain. Twenty-four-hour pH monitoring with a symptom-index correction may define an association but does not prove causality between the patient's chest pain and GERD. Recent studies have implied that high-dose proton pump inhibitor (PPI) therapy for one week is an effective approach. The PPI test has excellent sensitivity/ specificity and economic savings (due to reduction in diagnostic procedures) and, accordingly, should be the diagnostic/ therapeutic approach of choice for patients with suspected GERD-induced chest pain.
authors.affiliation: Department of Gastroenterology, Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Richter
mesh_terms: D000465:Algorithms; D002637:Chest Pain / Q000209:etiology*; D003937:Diagnosis, Differential; D005745:Gastric Acidity Determination; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis; D006801:Humans