[Circadian rhythms of hypophysis-thyroid hormones secretion in patients with bronchial asthma].
OBJECTIVE
To examine circadian rhythms of hypophysiothyroid system in patients with bronchial asthma and effects of exogenic glucocorticoids on thyroid function.


METHODS
Free T3, T4 and TTH were measured in plasma using immunochemiluminescence in 16 patients with nonallergic bronchial asthma running a severe course. The plasma samples were taken each 6 hours for 48 hours.


RESULTS
In patients with severe bronchial asthma (SBA) thyroid functional activity changed. Production of T3 increased while that of T4 dropped at night. TTH concentration rhythm for 24 hours was like that in healthy subjects. Glucocorticoids induced no significant changes in circadian rhythms of hypophysiothyroid system in SBA patients.


CONCLUSIONS
In SBA functional activity of the hypophysiothyroid system changes with rearrangement of hormonal production at night.
Landyshev
Iu S
IuS
Mishchuk
V P
VP
Lysenko
V A
VA
Petrov
A V
AV
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D015415:Biomarkers / Q000097:blood; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D010907:Pituitary Hormones / Q000097:blood / Q000378:metabolism*; D011379:Prognosis; D012720:Severity of Illness Index; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013963:Thyroid Hormones / Q000097:blood / Q000378:metabolism*
D015415:Biomarkers; D005938:Glucocorticoids; D010907:Pituitary Hormones; D013963:Thyroid Hormones