title: [Clinical applications of photodynamic therapy in the treatment of laryngeal lesions].
abstract: Photodynamic therapy (PDT) has been used in the treatment of laryngeal lesions. The disorders comprised primary dysplasia and leukoplakia of the vocal cords. The patients after diagnosis were subjected to the therapy. Six hours prior to the light irradiation the patients received 4% solution of delta-aminolevulinic acid (ALA) during 30 minutes inhalation. After 6 hours all the changes were irradiated using 400 nm wavelength light from 300 W halogen lamp (range: 380-420 nm) in order to visualize them. Next, the wavelength was tuned to 650 nm (range 620-680 nm) and the total dose 120 J/cm2 for all cases. Control examinations in patients revealed complete response of the lesions within 2-3 months after PDT.
authors.affiliation: Oddział Laryngologiczny, Szpital Rejonowy w Oławie.
authors.forename: M
authors.initials: M
authors.lastname: Malczewski
authors.forename: J
authors.initials: J
authors.lastname: Birecki
authors.forename: K
authors.initials: K
authors.lastname: Symonowicz
authors.forename: A
authors.initials: A
authors.lastname: Bronowicz
authors.forename: P
authors.initials: P
authors.lastname: Ziółkowski
authors.forename: J
authors.initials: J
authors.lastname: Rabczyński
authors.forename: K
authors.initials: K
authors.lastname: Barańska
authors.forename: P
authors.initials: P
authors.lastname: Marszalik
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D007971:Leukoplakia / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D014827:Vocal Cords / Q000473:pathology
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid