title: [Usefulness of spect with 99mTc-tetrofosmin and stimulus with dipyridamole in patients with left bundle branch block of His].
abstract: BACKGROUND
  In patients with left bundle branch block, the 201Tl scintigraphic studies show high sensitivity, but with low specificity, in the diagnosis of coronary artery disease.
  
  
  OBJECTIVE
  [corrected] To assess the value of 99mTc-tetrofosmin Single Photon Emission Computed Tomography (SPECT) and dipyridamole administration in patients with left bundle branch block.
  
  
  METHODS
  22 patients with angina and left bundle branch block were retrospectively studied by cardiac catheterization and Tc-Tf after dipyridamole administration (0,142 mg/kg/min. i.v.) and at rest.
  
  
  RESULTS
  The mean number of territories with perfusion defects was 1.5+/-1.0, and the average number of diseased vessels in the coronariographic study was 1.6+/-1.3 (r = 0.77, p<0.001). Sensitivity, specificity, positive predictive value, negative predictive value, total predictive value and Kappa index in the diagnosis of multivessel disease were 92%, 90%, 92%, 90%, 91% and 0.82, respectively. In the diagnosis of anterior descending artery disease, these values were 83%, 70%, 77%, 78%, 77%, and 0.54, respectively.
  
  
  CONCLUSIONS
  In patients with angina and left bundle branch block, SPECT with Tc-Tf-dipyridamole is of great value in the study of coronary artery disease extension. Sensitivity and specificity for the diagnosis of anterior descending artery disease were similar to that shown in series with thallium-dipyridamole.
authors.affiliation: Servicio de Medicina Nuclear, Hospital General Universitario Gregorio Marañón, Madrid 28007, España.
authors.forename: A
authors.initials: A
authors.lastname: Ortega
authors.forename: R
authors.initials: R
authors.lastname: Moreno
authors.forename: P
authors.initials: P
authors.lastname: Domínguez
authors.forename: I
authors.initials: I
authors.lastname: Almoguera
authors.forename: A
authors.initials: A
authors.lastname: Bittini
authors.forename: J
authors.initials: J
authors.lastname: Lampreave
authors.forename: M
authors.initials: M
authors.lastname: Suárez
authors.forename: V
authors.initials: V
authors.lastname: Sosa
authors.forename: M
authors.initials: M
authors.lastname: García-Fernández
authors.forename: J
authors.initials: J
authors.lastname: Delcán
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Vázquez
mesh_terms: D002036:Bundle of His / Q000000981:diagnostic imaging*; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging*; D004176:Dipyridamole; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin; D004176:Dipyridamole