title: Optical and atomic force microscopy of an explanted AcrySof intraocular lens with glistenings.
abstract: OBJECTIVE
  To assess the surface morphology and cause of glistenings in an explanted AcrySof intraocular lens (IOL).
  
  
  METHODS
  Shakai Hoken Kobe Central Hospital, Kobe, Japan.
  
  
  METHODS
  A 63-year-old Japanese man had implantation of an AcrySof IOL in the capsular bag. One month postoperatively, he had a neodymium:YAG laser capsulotomy for posterior capsule opacification, which changed the IOL's position in the capsular bag. A few months later, the patient developed disabling night glare from intralenticular glistenings and progressive hyperopic refractive error. The IOL was explanted and then analyzed by optical microscopy and atomic force microscopy (AFM). Laboratory analysis of control AcrySof IOLs kept in a balanced salt solution at steady room and body temperature for 2 months was also performed to evaluate the cause of the glistenings observed clinically.
  
  
  RESULTS
  Optical microscopy showed that the explanted AcrySof IOL had several microvacuoles; no abnormalities were observed in the control AcrySof IOLs before or after folding at the room and body temperatures. The AFM analysis showed a significant change in the surface morphology of the explanted IOL, including vacuolar formations in the posterior surface as well as numerous anterior surface irregularities. No microvacuoles or surface morphology alterations were observed in the control AcrySof IOLs by AFM analysis.
  
  
  CONCLUSIONS
  The glistenings in the explanted AcrySof IOL were likely caused by temperature changes and not mechanical stress from folding.
authors.affiliation: Department of Ophthalmology, Kobe Kaisei Hospital, Kobe, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Dogru
authors.forename: K
authors.initials: K
authors.lastname: Tetsumoto
authors.forename: Y
authors.initials: Y
authors.lastname: Tagami
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Nakamae
mesh_terms: D000180:Acrylic Resins; D019466:Glare; D006801:Humans; D053685:Laser Therapy; D007903:Lens Capsule, Crystalline / Q000473:pathology / Q000601:surgery; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D018625:Microscopy, Atomic Force; D008875:Middle Aged; D011475:Prosthesis Failure; D019591:Pseudophakia / Q000601:surgery; D012086:Reoperation
chemical_list: D000180:Acrylic Resins