title: Evaluation of [O-methyl-(11)C]fluvoxamine as a tracer for serotonin re-uptake sites.
abstract: We evaluated [(11)C]fluvoxamine as a tracer for the serotonin re-uptake site. Studies of the distribution of the tracer in rat and primate brain showed adequate uptake of [(11)C]fluvoxamine, but failed to reveal regions with known high density of serotoninergic re-uptake sites. Pretreatment with unlabeled fluvoxamine did not substantially change the distribution. In rat brain tissue, nearly all radioactivity represented intact [(11)C]fluvoxamine. [(11)C]Fluvoxamine does not function as a tracer for serotonin re-uptake sites, owing to high nonspecific binding in the brain.
authors.affiliation: CNR-INB, University of Milan, Institute H.S. Raffaele, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Wollmer
authors.forename: R M
authors.initials: RM
authors.lastname: Moresco
authors.forename: P
authors.initials: P
authors.lastname: Simonelli
authors.forename: M
authors.initials: M
authors.lastname: Matarrese
authors.forename: M
authors.initials: M
authors.lastname: Rigamonti
authors.forename: G
authors.initials: G
authors.lastname: Ortu
authors.forename: R
authors.initials: R
authors.lastname: LaGaetana
authors.forename: D
authors.initials: D
authors.lastname: Soloviev
authors.forename: M
authors.initials: M
authors.lastname: Galli
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D016666:Fluvoxamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008254:Macaca nemestrina; D008297:Male; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
chemical_list: D016666:Fluvoxamine; D019275:Radiopharmaceuticals; D011985:Receptors, Serotonin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C107760:O-methyl-fluvoxamine