title: Synthesis and antifungal activity of rhodopeptin analogues. 2. Modification of the west amino acid moiety.
abstract: Structure-activity relationships of the west amino acid modified analogues of rhodopeptins, novel antifungal tetrapeptide isolated from Rhodococcus species Mer-N1033, have been investigated. Among the analogues synthesized, 2,2-difluoro and 2-hydroxy derivatives retained the antifungal activity with better physical properties, i.e., solubility or acute toxicity.
authors.affiliation: New Product Research Laboratories I, Daiichi Pharmaceutical Co. Ltd, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Nakayama
authors.forename: H C
authors.initials: HC
authors.lastname: Kawato
authors.forename: H
authors.initials: H
authors.lastname: Inagaki
authors.forename: R
authors.initials: R
authors.lastname: Nakajima
authors.forename: A
authors.initials: A
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Someya
authors.forename: T
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D012240:Rhodococcus / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000935:Antifungal Agents; D010456:Peptides, Cyclic