[Effect of intrafollicular interleukin-6 levels on the secretion of estradiol and progesterone in patients treated with in vitro fertilization and embryo transfer].
The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. The levels of IL-6 were measured in follicular fluid of 15 patients undergone to in vitro fertilization and embryo transfer and correlated with the values of seric estradiol and progesterone. There were a negative correlation between follicular levels of IL-6 and either estradiol and progesterone. Four patients achieved pregnancy following embryo transfer (pregnancy rate 26.6%), one of them aborted. As conclusion, the increased levels of IL-6 may be a reaction to controlled ovarian hyper-stimulation and probably a protective response. According to the reduction of estradiol, there may be a subtle reduction in aromatase action by effect of IL-6 and other cytokines.
Barrón Vallejo
J
J
Hospital Angeles de las Lomas, Unidad de Reproducción Asistida, México, C.P. ivfjesus@data.net.mx
Corona de Lau
C
C
Méndez Espinosa
G
G
Diez Castillo
I
I
Karchmer Krivitzky
S
S
Kably Ambe
A
A
D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D007118:Immunoassay; D015850:Interleukin-6 / Q000032:analysis*; D010062:Ovulation Induction; D010783:Photometry; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*
D015850:Interleukin-6; D011374:Progesterone; D004958:Estradiol