title: Occlusion of experimentally created fusiform aneurysms with porous metallic stents.
abstract: OBJECTIVE
  Carotid fusiform aneurysms are most commonly treated with occlusion of the parent vessel. The purpose of our study was to assess the effectiveness of self-expanding, cobalt-alloy stents in the ablation of experimental fusiform aneurysms with preservation of the parent vessel in a carotid artery model.
  
  
  METHODS
  Porous metallic stents were placed endovascularly along the lengths of experimentally created fusiform aneurysms in the carotid arteries of dogs; aneurysms were also created in the animals' opposite carotid arteries to serve as controls.
  
  
  RESULTS
  Before stent placement, angiography of the carotid arteries showed large fusiform aneurysms along the lengths of the common carotid arteries and complex patterns of flow. Immediately after stent placement there was disruption of the usual flow patterns within the lumens of the fusiform aneurysms. The lumen between the wall of the aneurysm and stented carotid showed stasis of contrast material and blood. Near-complete ablation of all aneurysms was observed 8 weeks after stent placement. The stented carotid arteries remained widely patent; control aneurysms and carotid arteries were patent and unchanged. Histopathologic analysis revealed fibrotic reactive scar tissue filling the space between the stent wires and outer wall of the fusiform aneurysm.
  
  
  CONCLUSIONS
  Changing blood flow dynamics within an aneurysm can promote thrombus formation. The stent promotes stasis and thrombus within the residual lumen between the stent wall and the outer wall of the aneurysm because its woven wire mesh interferes with usual blood flow patterns, which then promotes formation of thrombus and fibrosis within the residual aneurysmal lumen.
authors.affiliation: Department of Radiology, Rush-Presbyterian-St Luke's Medical Center, Chicago, IL 60612, USA.
authors.forename: G
authors.initials: G
authors.lastname: Geremia
authors.forename: T
authors.initials: T
authors.lastname: Brack
authors.forename: L
authors.initials: L
authors.lastname: Brennecke
authors.forename: M
authors.initials: M
authors.lastname: Haklin
authors.forename: R
authors.initials: R
authors.lastname: Falter
mesh_terms: D000783:Aneurysm / Q000473:pathology / Q000628:therapy*; D000818:Animals; D002340:Carotid Artery Diseases / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D016062:Porosity; D015607:Stents