[Pharmacological approaches to study of choline- and GABA-receptor sta tes in neuronal membranes after low doses irradiation].
As a result of the study of both the acetylcholine (10(-10) M; 10(-6) M) and gamma-aminobutyric acid (10(-9) M; 10(-5) M) effects on active K+ transport in rat brain cortex slices using any selective antagonists of cholinoreceptors (ChR) and GABA-receptors (GABA-R) it had been shown that after whole-body 25 cGy irradiation (1.75 mGy/min) metabotropic muscarinic ChR and GABAB-R were involved into processes of neurotransmitter modulation, whereas under the normal conditions they were mediated via ionotropic nicotinic ChR and GABAA-R. Observed changes were supposed to be an adaptive reaction. Perhaps, postirradiation structure-functional disorders in receptors were pointed as one of the reasons leading to essential changes in the interneuronal metabolic communication processes in CNS.
Anan'eva
T V
TV
Research Institute of Biology, Dnepropetrovsk University, Ukraine.
Dvoretskiĭ
A I
AI
D000109:Acetylcholine / Q000378:metabolism / Q000494:pharmacology; D000220:Adaptation, Biological; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000528:radiation effects* / Q000648:ultrastructure; D002462:Cell Membrane / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*; D018080:Receptors, GABA-B / Q000378:metabolism*; D014916:Whole-Body Irradiation; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology
D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D011188:Potassium