title: Isolation of 10-hydroxycoronaridine from Tabernaemontana penduliflora and its estrogen-like activity.
abstract: The methanol extract of Tabernaemontana penduliflora was found to appreciably inhibit [3H]-estradiol binding to estrogen receptors. Activity-guided fractionation led to the isolation of two known alkaloids, 10-hydroxycoronaridine (1) and its 10-O-methyl ether, voacangine (2). These alkaloids together with other related alkaloids were tested for their estrogenic activities. Among these molecules, 1 was found to be the most potent estrogen agonist and is distinctly more active than genistein.
authors.forename: K
authors.initials: K
authors.lastname: Masuda
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
authors.forename: M
authors.initials: M
authors.lastname: Taki
authors.forename: S
authors.initials: S
authors.lastname: Takaishi
authors.forename: Y
authors.initials: Y
authors.lastname: Iijima
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
authors.forename: N
authors.initials: N
authors.lastname: Aimi
authors.forename: J
authors.initials: J
authors.lastname: Jato
authors.forename: P G
authors.initials: PG
authors.lastname: Waterman
mesh_terms: D002455:Cell Division / Q000187:drug effects; D004968:Estrogens, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010944:Plants / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D004968:Estrogens, Non-Steroidal; D006576:Heterocyclic Compounds, 4 or More Rings; C407862:10-hydroxycoronaridine