title: Simultaneous development of a pineal tumor and an intradural spinal mass during remission of acute lymphocytic leukemia.
abstract: A small percentage of children with acute lymphocytic leukemia experience relapse in the central nervous system in spite of prophylaxis. Diffuse leptomeningeal infiltration is common but an intracranial leukemic mass or spinal cord involvement is a rare manifestation. We report a child with acute lymphocytic leukemia who simultaneously developed a pineal tumor and an intradural spinal cord mass as her first relapse. She was successfully managed by comprehensive combined treatment including peripheral blood stem cell transplantation. She remains in continuous complete remission for more than 5 years without further evidence of neurological sequelae.
authors.affiliation: Department of Pediatrics, School of Medicine, Sapporo Medical University, Japan. tkudoh@sapmed.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kudoh
authors.forename: H
authors.initials: H
authors.lastname: Otoi
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Oda
authors.forename: S
authors.initials: S
authors.lastname: Katoh
authors.forename: H
authors.initials: H
authors.lastname: Akiba
authors.forename: M
authors.initials: M
authors.lastname: Hareyama
authors.forename: S
authors.initials: S
authors.lastname: Chiba
mesh_terms: D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010871:Pinealoma / Q000556:secondary*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D012008:Recurrence; D013117:Spinal Cord Compression / Q000209:etiology; D013120:Spinal Cord Neoplasms / Q000556:secondary*