Evaluation of [O-methyl-(11)C]fluvoxamine as a tracer for serotonin re-uptake sites.
We evaluated [(11)C]fluvoxamine as a tracer for the serotonin re-uptake site. Studies of the distribution of the tracer in rat and primate brain showed adequate uptake of [(11)C]fluvoxamine, but failed to reveal regions with known high density of serotoninergic re-uptake sites. Pretreatment with unlabeled fluvoxamine did not substantially change the distribution. In rat brain tissue, nearly all radioactivity represented intact [(11)C]fluvoxamine. [(11)C]Fluvoxamine does not function as a tracer for serotonin re-uptake sites, owing to high nonspecific binding in the brain.
Wollmer
P
P
CNR-INB, University of Milan, Institute H.S. Raffaele, Milan, Italy.
Moresco
R M
RM
Simonelli
P
P
Matarrese
M
M
Rigamonti
M
M
Ortu
G
G
LaGaetana
R
R
Soloviev
D
D
Galli
M
M
Fazio
F
F
D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D016666:Fluvoxamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008254:Macaca nemestrina; D008297:Male; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D016666:Fluvoxamine; D019275:Radiopharmaceuticals; D011985:Receptors, Serotonin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C107760:O-methyl-fluvoxamine