title: Risk stratification in heart surgery: comparison of six score systems.
abstract: OBJECTIVE
  Risk scores have become an important tool in patient assessment, as age, severity of heart disease, and comorbidity in patients undergoing heart surgery have considerably increased. Various risk scores have been developed to predict mortality after heart surgery. However, there are significant differences between scores with regard to score design and the initial patient population on which score development was based. It was the purpose of our study to compare six commonly used risk scores with regard to their validity in our patient population.
  
  
  METHODS
  Between September 1, 1998 and February 28, 1999, all adult patients undergoing heart surgery with cardiopulmonary bypass in our institution were preoperatively scored using the initial Parsonnet, Cleveland Clinic, French, Euro, Pons, and Ontario Province Risk (OPR) scores. Postoperatively, we registered 30-day mortality, use of mechanical assist devices, renal failure requiring hemodialysis or hemofiltration, stroke, myocardial infarction, and duration of ventilation and intensive care stay. Score validity was assessed by calculating the area under the ROC curve. Odds ratios were calculated to investigate the predictive relevance of risk factors.
  
  
  RESULTS
  Follow-up was able to be completed in 504 prospectively scored patients. Receiver operating characteristics (ROC) curve analysis for mortality showed the best predictive value for the Euro score. Predictive values for morbidity were considerably lower than predictive values for mortality in all of the investigated score systems. For most risk factors, odds ratios for mortality were substantially different from ratios for morbidity.
  
  
  CONCLUSIONS
  Among the investigated scores, the Euro score yielded the highest predictive value in our patient population. For most risk factors, predictive values for morbidity were substantially different from predictive values for mortality. Therefore, development of specific morbidity risk scores may improve prediction of outcome and hospital cost. Due to the heterogeneity of morbidity events, future score systems may have to generate separate predictions for mortality and major morbidity events.
authors.affiliation: Department of Cardiothoracic Surgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50924, Cologne, Germany. hans.geissler@medizin.uni-koeln.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Geissler
authors.forename: P
authors.initials: P
authors.lastname: Hölzl
authors.forename: S
authors.initials: S
authors.lastname: Marohl
authors.forename: F
authors.initials: F
authors.lastname: Kuhn-Régnier
authors.forename: U
authors.initials: U
authors.lastname: Mehlhorn
authors.forename: M
authors.initials: M
authors.lastname: Südkamp
authors.forename: E R
authors.initials: ER
authors.lastname: de Vivie
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures / Q000379:methods / Q000401:mortality*; D002315:Cardiopulmonary Bypass / Q000379:methods / Q000401:mortality*; D005069:Evaluation Studies as Topic; D005260:Female; D005858:Germany; D006331:Heart Diseases / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011336:Probability; D012372:ROC Curve; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016019:Survival Analysis; D015996:Survival Rate