Autoreactivity against matrilin-1 in a patient with relapsing polychondritis.
Relapsing polychondritis (RP) is a rare inflammatory disease of cartilage. Chondritis of the auricular, nasal, and tracheal cartilages predominates in this disease, suggesting a response to a tissue-specific antigen. One potential antigen is matrilin-1, a cartilage matrix protein found uniquely in the tracheal, auricular, and nasal cartilage of adults. We describe herein a patient with RP who had both a humoral and a cellular immune response directed toward the cartilage matrix protein matrilin-1.
Buckner
J H
JH
Virginia Mason Research Center, Seattle, Washington 98101-2795, USA.
Wu
J J
JJ
Reife
R A
RA
Terato
K
K
Eyre
D R
DR
D000368:Aged; D000917:Antibody Formation; D001323:Autoantibodies / Q000276:immunology; D015153:Blotting, Western; D002356:Cartilage; D064236:Cartilage Oligomeric Matrix Protein; D004247:DNA / Q000302:isolation & purification; D016326:Extracellular Matrix Proteins / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006098:Granulocytes / Q000737:chemistry; D006650:Histocompatibility Testing; D006801:Humans; D007111:Immunity, Cellular; D064235:Matrilin Proteins; D011081:Polychondritis, Relapsing / Q000276:immunology*
D001323:Autoantibodies; D064236:Cartilage Oligomeric Matrix Protein; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; C577539:MATN1 protein, human; D064235:Matrilin Proteins; C577553:TSP5 protein, human; D004247:DNA