[Morpho-biochemical study of the liver and serum albumins during tetrachloromethane intoxication and administration of antihypoxants, antioxidants, and actoprotectors].
Organism intoxication with tetrachloromethane induces a complex of transformations in the liver and serum albumins system manifested in the liver as necroses in the central lobe, dilatation of sinus capillaries and blood stasis in them, increased content of total water, and changed magneto-relaxation properties indicating decreased structurization of water. The system of serum albumins shows decreased total concentration of albumins in the serum, decreased constant of 1-(phenylamino)-8-sulfonaphthalene probe binding, increased mean number of probe binding per albumin molecule, and increased accessibility of probe in the protein-probe complex for the quencher indicating changed type of interaction between the protein and fluorescent probe. Introduction of a antihypoxant, antioxidant, or actoprotector has a positive effect on the condition of the liver and serum albumins system: The studied indices are nearly completely normalized.
Dubovaia
T K
TK
Russian State Medical University, Moscow, Russia.
Tsibulevskiĭ
A Iu
AIu
Deev
A I
AI
Sergeev
A I
AI
Bykov
A V
AV
Evstaf'eva
N Ia
NIa
Semushin
B V
BV
D000418:Albumins / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002252:Carbon Tetrachloride Poisoning / Q000097:blood* / Q000473:pathology*; D005456:Fluorescent Dyes; D008099:Liver / Q000473:pathology*; D008297:Male; D009336:Necrosis; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
C107499:5-ethoxy-2-ethylthiobenzimidazole; D000418:Albumins; D000975:Antioxidants; D001562:Benzimidazoles; D005456:Fluorescent Dyes; D002084:Butylated Hydroxytoluene; D012978:Sodium Oxybate