title: Transdermal fentanyl during high-dose chemotherapy and autologous stem cell support.
abstract: We report on our experience in the use of transdermal fentanyl in management of acute pain due to mucositis WHO-grade IV during high-dose chemotherapy (HDC) and autologous stem cell support (APBSCT). Between 8/96 and 12/98 74 patients received HDC and PBSCT for progressive disease or relapse of non-Hodgkin's lymphoma (n=32), multiple myeloma (n=37), Hodgkin's lymphoma (n=5). All patients suffered from mucositis WHO-grade IV with a need for continuous pain management. Instead of pethidine i.v. fentanyl TTS was used. Sufficient analgesia was achieved mostly with a dose of 50 microg/h. There was no need of supplementary analgesia. Relevant fentanyl-associated side effects were not seen. Patient compliance and acceptance were excellent. The results suggest that transdermal fentanyl is reliable in pain management of chemotherapy-associated mucositis grade IV.
authors.affiliation: Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University Dusseldorf, D-40225 Dusseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Strupp
authors.forename: T
authors.initials: T
authors.lastname: Sudhoff
authors.forename: U
authors.initials: U
authors.lastname: Germing
authors.forename: A
authors.initials: A
authors.lastname: Hunerliturkoglu
authors.forename: P
authors.initials: P
authors.lastname: Schneider
authors.forename: A
authors.initials: A
authors.lastname: Niederste-Hollenberg
authors.forename: A
authors.initials: A
authors.lastname: Heyll
authors.forename: C
authors.initials: C
authors.lastname: Aul
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D009101:Multiple Myeloma / Q000503:physiopathology / Q000628:therapy*; D010146:Pain / Q000517:prevention & control; D012008:Recurrence
chemical_list: D000701:Analgesics, Opioid; D008614:Meperidine; D005283:Fentanyl