The journey of the malaria parasite in the mosquito: hopes for the new century.
In this review, Anil Ghosh, Marten Edwards and Marcelo Jacobs-Lorena follow the journey of the Plasmodium parasite in the mosquito vector. At each developmental step, they highlight some of the major unanswered questions currently challenging cell and molecular biologists. A more thorough understanding of Plasmodium-mosquito interactions might lead to the development of mosquitoes unable to support parasite development.
Ghosh
A
A
Case Western Reserve University, Department of Genetics, 10900 Euclid Avenue, Cleveland, OH 44106-4955, USA.
Edwards
M J
MJ
Jacobs-Lorena
M
M
D000818:Animals; D000852:Anopheles / Q000469:parasitology*; D005260:Female; D006790:Host-Parasite Interactions; D007303:Insect Vectors / Q000469:parasitology*; D016778:Malaria, Falciparum / Q000469:parasitology* / Q000635:transmission; D008297:Male; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000502:physiology; D012469:Salivary Glands / Q000469:parasitology