The factor V Leiden mutation: a possible contributor to the hepatic artery thrombosis encountered after liver transplantation in a child.
A 10-year-old girl has experienced 3 recurrences of hepatic artery thrombosis (HAT) after a liver transplantation. She responded to intraarterial administrations of urokinase after the first 2 attacks. However, the restoration of the arterial flow was not possible after the third attack. The child and her father were both heterozygous for factor V Leiden mutation. In addition to the technical factors, the factor V Leiden mutation should be considered as a factor that plays a role in HAT.
Tanyel
F C
FC
Department of Pediatric Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Ocal
T
T
Balkanci
F
F
Cekirge
S
S
Senocak
M E
ME
Büyükpamukçu
N
N
Gürgey
A
A
D002648:Child; D005165:Factor V / Q000235:genetics*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D009154:Mutation; D012008:Recurrence; D013927:Thrombosis / Q000209:etiology / Q000235:genetics*
D005165:Factor V