Increased concentrations of plasma neuropeptide Y in patients with eclampsia and preeclampsia.
OBJECTIVE
Epinephrine and norepinephrine are associated with the hyperstimulation of the sympathetic nervous system. Neuropeptide Y is a potent vasoconstrictive substance that is released in response to sympathetic nerve stimulation.


METHODS
The concentrations of plasma neuropeptide Y in pregnant patients with eclampsia (n = 8), preeclampsia (n = 8), and normotension (n = 8) were measured by radioimmunoassay on admission and 6 days after delivery. Correlations between plasma concentration of neuropeptide Y and mean arterial blood pressure were also evaluated in these patients on admission and 6 days after delivery.


RESULTS
The plasma level of neuropeptide Y in women with eclampsia (P <.001) and preeclampsia (P <.003) was found to be significantly elevated with respect to that in normotensive pregnant women. At 6 days after delivery the concentration of plasma neuropeptide Y was significantly decreased in women with eclampsia, women with preeclampsia, and women with normotensive pregnancies compared with the value measured on admission (P <.0001, P <.0001, and P <.002, respectively). At admission the plasma neuropeptide Y level was positively correlated with mean arterial blood pressure in women with eclampsia and preeclampsia. However, no significant correlations were observed between plasma neuropeptide Y concentration and mean arterial blood pressure both at admission and 6 days after delivery in normotensive pregnant women and 6 days after delivery in women with eclampsia and preeclampsia.


CONCLUSIONS
We have concluded that the level of neuropeptide Y in plasma is increased in women with eclampsia and preeclampsia. Elevated plasma neuropeptide Y levels may play a key role in the development of eclampsia and preeclampsia.
Khatun
S
S
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan.
Kanayama
N
N
Belayet
H M
HM
Bhuiyan
A B
AB
Jahan
S
S
Begum
A
A
Kobayashi
T
T
Terao
T
T
D000328:Adult; D001794:Blood Pressure; D004461:Eclampsia / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D009478:Neuropeptide Y / Q000097:blood*; D009994:Osmolar Concentration; D049590:Postpartum Period / Q000097:blood / Q000502:physiology; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D012016:Reference Values
D009478:Neuropeptide Y