Sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphynyl(IX)-6,7-dia spartic acid (ATX-S10).
The sonodynamically induced antitumor effect of 4-formyloximethylidene-3-hydroxy-2-vinyl-deuterio-porphyn yl(IX)-6,7-diaspartic acid (ATX-S10) was investigated. Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. The rate of ultrasonically induced damage to isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 microM ATX-S10. This enhancement was significantly inhibited by histidine, which may suggest that it was mediated by ultrasonically induced oxidation. The coadministraion of 25 mg/kg ATX-S10 followed by ultrasonic exposure at 2 MHz stopped the growth of implanted colon 26 tumors at an intensity at which ultrasound alone showed only a slight antitumor effect.
Yumita
N
N
School of Pharmaceutical Sciences, Toho University, Miyama, Funabashi, Chiba.
Nishigaki
R
R
Sakata
I
I
Nakajima
S
S
Umemura
S
S
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006639:Histidine / Q000494:pharmacology; D017665:Hydroxyl Radical; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000628:therapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology*; D014464:Ultrasonic Therapy
C115550:ATX-S10; D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; D017665:Hydroxyl Radical; D006639:Histidine