Chemokines in tissue-specific and microenvironment-specific lymphocyte homing.
This review describes recent breakthroughs in our understanding of the roles played by chemokines in lymphocyte trafficking. These include the first demonstration that chemokines control lymphocyte/vascular recognition by shear-resistant rapid adhesion; the first example of specialized tissue-specific homing mediated by chemokines; and the implication that chemokines may control microenvironmental segregation within lymphoid organs.
Campbell
J J
JJ
Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5324, USA.
Butcher
E C
EC
D002448:Cell Adhesion; D054421:Chemokine CCL21; D018925:Chemokines; D019742:Chemokines, CC; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D007157:Immunologic Surveillance; D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D054400:Receptors, CCR7; D019707:Receptors, Chemokine; D014018:Tissue Distribution
D054421:Chemokine CCL21; D018925:Chemokines; D019742:Chemokines, CC; D054400:Receptors, CCR7; D019707:Receptors, Chemokine