title: Synphilin-1 is present in Lewy bodies in Parkinson's disease.
abstract: Alpha-synuclein is believed to play an important role in Parkinson's disease (PD). Mutations in the alpha-synuclein gene are responsible for familial forms of PD and alpha-synuclein protein is a major component of Lewy bodies in patients with sporadic PD. Synphilin-1 is a novel protein that we have previously found to associate in vivo with alpha-synuclein. We now show that synphilin-1 is present in Lewy bodies of patients with PD. Our data suggest that synphilin-1 could play a role in Lewy body formation and the pathogenesis of PD.
authors.affiliation: Brain Disease Research Center, Brain Research Institute, Niigata University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: S
authors.initials: S
authors.lastname: Engelender
authors.forename: M
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: S
authors.initials: S
authors.lastname: Tsuji
authors.forename: C A
authors.initials: CA
authors.lastname: Ross
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000906:Antibodies; D015153:Blotting, Western; D002352:Carrier Proteins / Q000032:analysis* / Q000276:immunology; D006801:Humans; D016631:Lewy Bodies / Q000737:chemistry* / Q000473:pathology*; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis* / Q000276:immunology; D009474:Neurons / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology*; D011817:Rabbits; D013378:Substantia Nigra / Q000473:pathology; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D000906:Antibodies; D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; C118958:SNCAIP protein, human; D051843:Synucleins; D051844:alpha-Synuclein