Selenoprotein P: properties, functions, and regulation.
Selenoprotein P (SeP) is a plasma protein which contains 10 selenocysteine residues per polypeptide. It accounts for more than 50% of the selenium content in rat and human plasma but its function is still not completely understood. However, a function as an extracellular antioxidant seems most probable. A protective function of SeP in human plasma against the potent endotoxin peroxynitrite and phospholipid hydroperoxide reducing activity was demonstrated in vitro. An association of SeP with the vascular endothelium, a prime target of peroxynitrite toxicity, was shown in vivo. SeP of bovine serum acts as a survival-promoting factor in neuronal cell culture. Analysis of the human SeP promoter indicates a transcriptional regulation of SeP by inflammatory mediators.
Mostert
V
V
Medizinisches Institut für Umwelthygiene an der Heinrich-Heine Universität Düsseldorf, Abteilung Experimentelle Toxikologie, Auf'm Hennekamp 50, Düsseldorf, 40225, Germany.
D000595:Amino Acid Sequence; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D016207:Cytokines / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology; D051149:Selenoprotein P; D051140:Selenoproteins
D000975:Antioxidants; D016207:Cytokines; D020033:Protein Isoforms; D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D012643:Selenium