Analysis of the Fv1 alleles involved in the susceptibility of mice to lactate dehydrogenase-elevating virus-induced polioencephalomyelitis.
Development of polioencephalomyelitis in mice infected with lactate dehydrogenase-elevating virus (LDV) requires expression of N-tropic ecotropic MuLV retroviruses. 129/Sv mice are resistant to N-tropic MuLV expression and therefore do not develop LDV-induced polioencephalomyelitis. The Fv1 gene determines the susceptibility to retrovirus replication. We sequenced the open reading frame of the Fv1nr allele of 129/Sv mice. It differs by only one nucleotide, modifying one amino acid in the encoded protein, from the Fv1n allele of susceptible AKR and C58 animals. We excluded that the resistance of 129/Sv mice to LDV-induced polioencephalomyelitis resulted from the absence of endogenous N-tropic retrovirus, by infecting (129/Sv x C58/J) F1 animals. Therefore it is possible that the amino acid that defines the Fv1nr allele is responsible for resistance of 129/Sv mice to N-tropic MuLV expression and to LDV-induced polioencephalomyelitis.
Monteyne
P
P
Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, Bruxelles, Belgium.
Coulie
P G
PG
Coutelier
J P
JP
D000483:Alleles; D000818:Animals; D018174:Arterivirus Infections / Q000235:genetics*; D018797:Cell Cycle Proteins; D020022:Genetic Predisposition to Disease; D007772:Lactate dehydrogenase-elevating virus / Q000235:genetics* / Q000472:pathogenicity; D009052:Leukemia Virus, Murine / Q000235:genetics / Q000472:pathogenicity; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D011051:Poliomyelitis / Q000209:etiology*; D011506:Proteins / Q000235:genetics*
D018797:Cell Cycle Proteins; C103189:Fv1 protein, mouse; D009363:Neoplasm Proteins; C498808:Prcc protein, mouse; D011506:Proteins