title: Fibroblast growth factor-1 inhibits medial smooth muscle cells apoptosis after balloon injury.
abstract: We performed balloon injury in the rat common carotid artery and identified apoptosis of vascular smooth muscle cells (VSMCs) by in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling, 2 h after injury. Balloon injury induces apoptosis and loss of bcl-X protein in the innermost layers of the media of the common carotid artery. Treatment with acidic fibroblast growth factor (aFGF, FGF-1) attenuated by 56% the balloon angioplasty-induced apoptosis. In addition, FGF-1 treatment also induces expression of the bcl-X anti-apoptotic protein in the same site of the media showing VSMC apoptosis. These data suggest that the anti-apoptotic effect of FGF in injured vascular wall was mediated by a bcl-X pathway and identified FGF as an important factor in vascular remodeling.
authors.affiliation: Servicio de Histologia, Hospital Ramón y Cajal, CSIC, Madrid, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Cuevas
authors.forename: F
authors.initials: F
authors.lastname: Carceller
authors.forename: D
authors.initials: D
authors.lastname: Reimers
authors.lastname: Giménez-Gallego
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D020212:Carotid Artery Injuries / Q000473:pathology / Q000503:physiopathology*; D017536:Carotid Artery, Common / Q000187:drug effects / Q000378:metabolism; D002404:Catheterization / Q000009:adverse effects*; D016220:Fibroblast Growth Factor 1; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D051020:bcl-X Protein
chemical_list: C494813:Bcl2l1 protein, rat; D019253:Proto-Oncogene Proteins c-bcl-2; D051020:bcl-X Protein; D016222:Fibroblast Growth Factor 2; D016220:Fibroblast Growth Factor 1