The advantages of ambiguous orientation.
Recent studies have revealed that although it is possible for certain transcription factors to bind in an orientated fashion on DNA, they have not evolved to do so. Rather, they rely on contacts with other proteins to precisely define their mode of binding.
Erlanson
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Sunesis Pharmaceuticals, Inc., Redwood City, CA 94063, USA. erlanson@sunesis-pharma.com
D000818:Animals; D004268:DNA-Binding Proteins / Q000737:chemistry*; D019281:Dimerization; D005453:Fluorescence; D008958:Models, Molecular; D016760:Proto-Oncogene Proteins c-fos / Q000737:chemistry; D016755:Proto-Oncogene Proteins c-jun / Q000737:chemistry; D018808:Transcription Factor AP-1 / Q000737:chemistry; D014157:Transcription Factors / Q000737:chemistry*
D004268:DNA-Binding Proteins; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D018808:Transcription Factor AP-1; D014157:Transcription Factors