Efficacy of topical acyclovir monophosphate, acyclovir, or penciclovir in orofacial HSV-1 infections of mice and genital HSV-2 infections of guinea pigs.
The purpose of these studies was to compare the efficacy of acyclovir monophosphate (ACVMP), acyclovir (ACV), or penciclovir (PCV) against HSV-1 in an orofacial infection of mice and against ACV sensitive and resistant genital HSV-2 infections of guinea pigs. Treatment was initiated 24, 48, or 72 hours post inoculation with 5% ACVMP, 5% ACV (Zovirax) or 1% PCV (Denavir). In all experiments, similar efficacy was obtained for ACVMP and ACV, whereas PCV was considerably less effective.
Kern
E R
ER
University of Alabama School of Medicine, Birmingham 35294-2170, USA.
Palmer
J
J
Szczech
G
G
Painter
G
G
Hostetler
K Y
KY
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000287:Administration, Topical; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006147:Guanine; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000473:pathology; D006560:Herpes Labialis / Q000188:drug therapy* / Q000473:pathology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D051379:Mice; D008812:Mice, Hairless
D000998:Antiviral Agents; C053539:penciclovir; D006147:Guanine; C026145:acyclovir monophosphate; D000212:Acyclovir