title: Central nervous system leiomyosarcoma in patients with acquired immunodeficiency syndrome. Report of two cases.
abstract: Leiomyosarcomas (LMSs) of the central nervous system are extremely rare; however, they are becoming more prevalent in immunocompromised patients. The authors present the cases of two patients with acquired immunodeficiency syndrome: one with LMS of the thoracic vertebral body and the other with LMS originating from the region of the cavernous sinus. The epidemiological and histological characteristics of LMS and its association with latent Epstein-Barr virus are discussed, as well as the treatments for this neoplasm.
authors.affiliation: Division of Neurosurgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Ritter
authors.forename: B H
authors.initials: BH
authors.lastname: Amaker
authors.forename: R S
authors.initials: RS
authors.lastname: Graham
authors.forename: W C
authors.initials: WC
authors.lastname: Broaddus
authors.forename: J D
authors.initials: JD
authors.lastname: Ward
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000821:virology; D002426:Cavernous Sinus / Q000473:pathology* / Q000821:virology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006566:Herpesviridae Infections / Q000175:diagnosis; D004854:Herpesvirus 4, Human; D006801:Humans; D016867:Immunocompromised Host; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000821:virology; D008579:Meningioma / Q000175:diagnosis; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000821:virology; D013904:Thoracic Vertebrae / Q000473:pathology* / Q000821:virology; D014412:Tumor Virus Infections / Q000175:diagnosis