Isopoly(S-carboxymethyl-L-cysteine) derivatives of nucleic acid bases: effects of D-cysteine derivatives on the interaction with DNA.
Isopoly(S-carboxymethyl-D-cysteine) derivatives of nucleic acid bases were prepared to study the effect of chirality on the complex formation with oligo-DNA. The D-cysteine unit in the L-cysteine oligomer caused decrease of Tm for the complex with DNA.
Inaki
Y
Y
Material and Life Science, Graduate School of Osaka University, Suita, Japan.
Nitomi
H
H
Tohnai
N
N
D020029:Base Pairing; D001483:Base Sequence; D003545:Cysteine; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D010455:Peptides; D013237:Stereoisomerism
D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D010455:Peptides; C036002:poly(S-carboxymethylcysteine); D004247:DNA; D003545:Cysteine