Clinical profile of sickle cell disease in Orissa.
Children comprised 52% of patients with Sickle Cell Disease (SCD). Types of Sickle Cell Disease encountered were SS (92.7%). SB thalassaemia (6.7%) and SD disease (0.7%). The disease was widespread in almost all castes and communities in the society; largest number of patients (20%) belonging to scheduled castes and only 1.4% were from scheduled tribes. Maximum number of cases were in the age group 2-4 and 4-6 years, many of whom died around this age. Besides attacks of pain, jaundice and anemia, frequent attacks of fever with anemia or only anemia in childhood were a predominant presenting feature. Splenic sequestration was frequent (10.1%). The patients usually had a steady state hemoglobin level of 6-10 g/dl, with which they thrived well. Fetal hemoglobin was 5-30%. Blood transfusion was not a frequent requirement, but prophylactic long acting penicillin was helpful in preventing frequency of crisis.
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Department of Medical Aid and Research Center, Burla, Orissa.
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D000293:Adolescent; D000986:Antisickling Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D006306:Health Surveys; D006450:Hemoglobin SC Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D012805:Sickle Cell Trait / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D015996:Survival Rate; D013789:Thalassemia / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology
D000986:Antisickling Agents