[The effect of bromantane on the cardiovascular and sympathetic-adrenal systems in animals].
Bromantan administration markedly increases the stroke and minute blood volume at a reduced heart rate and peripheral resistance in anaesthetized rats, while the systemic arterial pressure exhibits an insignificant short-time increase. Bromantan also weakly increases the pressor effects of adrenaline and noradrenaline. In anaesthetized cats, bromantan modifies the shape of the amplitude-frequency characteristic of EEG measured in the upper cervical ganglion, reducing (against the initial level) the induced potential in the frequency range of the preganglionic fiber stimulation (1-10 and 25-30 Hz). In freely moving rats, capable of well-learnt Sidman's [correction of Seedman's] operant activity, bromantan showed a reliable tendency to decrease the rate of noradrenaline and adrenaline excretion with urine.
Morozov
I S
IS
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Efimova
L P
LP
Kryzhanovskiĭ
S A
SA
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects*; D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D002395:Catecholamines / Q000652:urine; D002415:Cats; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D002395:Catecholamines; D011619:Psychotropic Drugs; D000547:Amantadine; C085955:bromantane