title: Synergism among ternary mixtures of fourteen sweeteners.
abstract: The purpose of the present study was to determine the degree of synergism of sweet taste among ternary mixtures of 14 sweeteners. A trained panel evaluated ternary mixtures of 14 sweeteners varying in chemical structure and type. The ternary mixtures that were tested were limited to those in which the compounds comprising the mixture were synergistic in binary combinations, according to an earlier study. All sweeteners in the ternary mixtures were isointense with 2% sucrose, according to a previously developed formulae. Each self-mixture was also tested (e.g. 2% sucrose + 2% sucrose + 2% sucrose). The triad with the highest mean sweetness intensity rating was alitame-neohesperidin dihydrochalcone-rebaudioside-A (10.8). This represents an increase of 99.4% when compared with the average of the self-mixtures. While this is greater than the maximum of 74% increase found for binary mixtures, more dyadic combinations of sweeteners tested previously exhibited synergism than ternary combinations tested here. However, most ternary mixtures were synergistic (significantly greater than the average of the three self-mixtures) to some degree.
authors.affiliation: Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA. sss@acpub.duke.edu
authors.forename: S S
authors.initials: SS
authors.lastname: Schiffman
authors.forename: E A
authors.initials: EA
authors.lastname: Sattely-Miller
authors.forename: B G
authors.initials: BG
authors.lastname: Graham
authors.forename: B J
authors.initials: BJ
authors.lastname: Booth
authors.forename: K M
authors.initials: KM
authors.lastname: Gibes
mesh_terms: D004357:Drug Synergism; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D013549:Sweetening Agents / Q000494:pharmacology*; D013649:Taste
chemical_list: D013549:Sweetening Agents