Sulcatin, a novel antiproliferative N-methylpyridinium alkaloid from the ascidian Microcosmus vulgaris.
A new N-methylpyridinium alkaloid, with an interesting antiproliferative activity in vitro, has been isolated from the Mediterranean tunicate Microcosmus vulgaris. Its structure has been elucidated by spectroscopic analysis, including extensive 2D NMR experiments.
Aiello
A
A
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131, Napoli, Italy.
Fattorusso
E
E
Menna
M
M
Iuvone
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005354:Fibrosarcoma / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D011422:Propionates / Q000302:isolation & purification* / Q000494:pharmacology; D011726:Pyridinium Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D011422:Propionates; D011726:Pyridinium Compounds; C409624:sulcatin