Transplantation osteoporosis and corticosteroid-induced osteoporosis in autoimmune diseases: experience with alfacalcidol.
The effect of alfacalcidol therapy on bone mineral density at the spine and proximal femur was evaluated in 112 transplant recipients (59 heart, 26 liver and 27 lung); 45 transplant cases served as controls (included in a randomised way in a placebo group) and in 42 rheumatoid arthritis cases. Liver and lung transplantation cases had before transplantation a lower bone density at the spine and femur compared to heart transplant cases. Heart transplant cases lost considerably more bone immediately after transplantation than liver and lung transplant recipients. A positive effect of 2 years alfacalcidol treatment (0.5-1 microgram/day) on bone loss was observed in all treated groups. Alfacalcidol was particularly effective against trabecular bone loss at the spine in rheumatoid arthritis patients and transplant recipients. There is a manifest difference in evolution between organ transplant groups and bone sites measured. Liver and lung transplant recipients respond better to therapy than cardiac recipients.
Dequeker
J
J
Arthritis and Metabolic Bone Disease Research Unit, University Hospitals K.U. Leuven, Pellenberg, Belgium.
Borghs
H
H
Van Cleemput
J
J
Nevens
F
F
Verleden
G
G
Nijs
J
J
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001327:Autoimmune Diseases / Q000188:drug therapy*; D015519:Bone Density / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D010024:Osteoporosis / Q000139:chemically induced* / Q000188:drug therapy; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D000305:Adrenal Cortex Hormones; D006887:Hydroxycholecalciferols; C008088:alfacalcidol