Choriocarcinoma arising in a squamous cell carcinoma of the esophagus.
Extragonadal germ cell tumors are rare neoplasms with histologic features comparable to those of gonadal origin. Squamous cell carcinoma of the esophagus was diagnosed in a 53-year-old male patient, and was palliated for a short period by cisplatin plus 5-fluorouracil. Clinical deterioration and development of gynecomastia led to diagnosis of hormone-secreting choriocarcinoma that originated within the squamous cell tumor of the esophagus. Salvage chemotherapy affected the markers but not the tumor. Extragonadal choriocarcinoma is a chemosensitive tumor, but when arising within squamous cell carcinoma of the esophagus it may be chemoresistant, and lead to a fatal outcome.
Merimsky
O
O
Department of Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv University, Israel.
Jossiphov
J
J
Asna
N
N
Shmueli
E
E
Stabsky
A
A
Inbar
M
M
D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D002822:Choriocarcinoma / Q000188:drug therapy / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D016879:Salvage Therapy
D014408:Biomarkers, Tumor