title: Correlation between deposition of immuno-components and infiltration pattern of polymorphonuclear leukocytes in the lesions of chronic urticaria.
abstract: Urticaria is often associated with perivascular infiltration of leukocytes into the lesions. Although mast cell-derived chemical mediators are considered to play crucial roles in the infiltration of leukocytes as well as in the dermal edema, other mechanisms for the leukocyte infiltration have not been well defined. This study revealed that approximately 25% of the cases of chronic idiopathic urticaria in whom wheals had continued for more than 12 h had deposition of immuno-components in the lesions, although histological examination of the lesions did not show leukocytoclastic vasculitis. In these lesions with deposition of immuno-components, both neutrophils and eosinophils had infiltrated at a constant ratio (approximately 2:1), whereas, in the lesions without deposition, a variable population of leukocytes was seen. This result suggests that activation of complements occurs in the lesions of a considerable percentage of patients with chronic idiopathic urticaria and that the complement fragments influence the infiltration patterns of polymorphonuclear leukocytes.
authors.affiliation: Department of Dermatology, Hiroshima University, Faculty of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sugita
authors.forename: E
authors.initials: E
authors.lastname: Morita
authors.forename: H
authors.initials: H
authors.lastname: Kawamoto
authors.forename: K
authors.initials: K
authors.lastname: Horiuchi
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: O
authors.initials: O
authors.lastname: Koro
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D003167:Complement Activation / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis; D004804:Eosinophils / Q000276:immunology; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration; D009504:Neutrophils / Q000276:immunology* / Q000473:pathology; D014581:Urticaria / Q000276:immunology* / Q000473:pathology
chemical_list: D007136:Immunoglobulins; D003165:Complement System Proteins