title: Massive solitary metastasis of hepatocellular carcinoma in the ovary two years after liver transplantation.
abstract: Case report of a 47-year-old woman with a mass in the lower abdomen, was referred to us by the surgeon, two years after orthotopic liver transplantation for hepatocellular carcinoma (HCC). Serum alpha-fetoprotein (AFP), which was elevated at the time of initial diagnosis, was in the normal range. Frozen section examination during exploratory laparotomy showed appearances consistent with metastatic HCC in the ovary. This was confirmed at the final pathological examination. Definitive pathological conclusions were based on the findings of tumor cells arranged in trabecular and papillary aggregates, and the presence of bile-pigment, along with the patients history. This is the sixth case of metastatic HCC in the ovary being described in literature and the first case in which this metastasis was not accompanied by elevated AFP.
authors.affiliation: Department of Obstetrics and Gynecology, Dijkzigt University Hospital Rotterdam, POB 2040, 3000 CA, Rotterdam, The Netherlands.
authors.forename: M E
authors.initials: ME
authors.lastname: de Groot
authors.forename: L
authors.initials: L
authors.lastname: Dukel
authors.forename: S
authors.initials: S
authors.lastname: Chadha-Ajwani
authors.forename: H J
authors.initials: HJ
authors.lastname: Metselaar
authors.forename: H W
authors.initials: HW
authors.lastname: Tilanus
authors.forename: F J
authors.initials: FJ
authors.lastname: Huikeshoven
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000556:secondary*; D005260:Female; D006801:Humans; D007813:Laparotomy; D008113:Liver Neoplasms / Q000473:pathology*; D016031:Liver Transplantation; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000556:secondary*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins