title: Initiators and propagators of the metabolic response to injury.
abstract: Injury produces tissue hypoperfusion and subsequent reperfusion, afferent neural activity, and immune and vascular endothelial activation. These, in turn, set up a cascade of events coordinated by the central nervous system and at the level of individual tissues such as the liver, gut, and skeletal muscle. They are mediated by a complex array of neutrophil and macrophage products. The changes result in hypermetabolism, lypolysis, lysis of skeletal muscle and visceral protein, and expanded extracellular fluid with consequent organ failure.
authors.affiliation: Department of Surgery, Africa Inland Church Kijabe Hospital, PO Box 20, Kijabe, Kenya. andrew-lori_hill@aimint.org
authors.forename: A G
authors.initials: AG
authors.lastname: Hill
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007378:Interleukins / Q000378:metabolism; D007422:Intestines / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D014947:Wounds and Injuries / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D016207:Cytokines; D007378:Interleukins; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha