title: Long-term Follow-up of Gastroplasty in a Patient with Prader-Willi Syndrome.
abstract: To prevent the development of metabolic disturbances caused by overeating, we performed vertical banded gastroplasty in an adult woman with Prader-Willi syndrome. Her fasting blood sugar (FBS) and urinary sugar excretion (US) decreased during 6 months after the surgery under strict dietary control in the hospital. The insulin response to oral glucose at 6 months after surgery was as good as in the normal controls. A barium meal study in the 11th postoperative month revealed that the staple line was partially ruptured. After this, FBS and US increased, and the glucose tolerance and insulin response worsened. At 24 months, US was still less than preoperative US, and the oral glucose tolerance test showed a better result than before operation. At 29 months, her condition was brought under control with use of Glibenclamide. At 60 months, her FBS and US were at the same level as before operation. She was doing a part-time job. In conclusion, the effect of gastroplasty in preventing worsening of glucose metabolism in a case of Prader-Willi syndrome lasted satisfactorily for 24 months in spite of the partial breakdown of the staple line.
authors.affiliation: The First Department of Surgery, Osaka University Medical School, Osaka Japan.
authors.initials: T
authors.lastname: Dousei
authors.initials: M
authors.lastname: Miyata
authors.initials: M
authors.lastname: Izukura
authors.initials: T
authors.lastname: Harada
authors.initials: T
authors.lastname: Kitagawa
authors.initials: H
authors.lastname: Matsuda