The anti-bacterial action of diclofenac shown by inhibition of DNA synthesis.
Most strains of Gram-positive and Gram-negative bacteria were inhibited by 50-100 mg/l of the anti-inflammatory agent, diclofenac sodium (Dc). In vivo test using 30 or 50 microg Dc per 20 g mouse (Swiss Albino variety) significantly (P <0.001) protected the animals when challenged with 50 MLD of a virulent Salmonella typhimurium. The anti-bacterial action of Dc was found to be due to inhibition of DNA synthesis which was demonstrated using 2 micro Ci (3H) deoxythymidine uptake.
Dastidar
S G
SG
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, 700 032, Calcutta, India.
Ganguly
K
K
Chaudhuri
K
K
Chakrabarty
A N
AN
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000096:biosynthesis; D004008:Diclofenac / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D051379:Mice; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013936:Thymidine / Q000032:analysis; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004269:DNA, Bacterial; D004008:Diclofenac; D013936:Thymidine