title: Germline BRCA2 mutation in a patient with fallopian tube carcinoma: a case report.
abstract: OBJECTIVE
  Fallopian tube carcinoma is similar to ovarian and peritoneal carcinoma with respect to histology, response to chemotherapy, and prognosis. BRCA germline mutations have been commonly reported in ovarian and peritoneal carcinoma but rarely in other gynecologic cancers.
  
  
  METHODS
  A patient with fallopian tube carcinoma and a family history of ovarian carcinoma underwent genetic counseling and BRCA testing as did her daughter.
  
  
  RESULTS
  The patient and her daughter were found to have a germline BRCA2 mutation.
  
  
  CONCLUSIONS
  Like a family history of ovarian or peritoneal carcinoma, the occurrence of fallopian tube cancer should alert the clinician to the possibility of an abnormality in the breast cancer susceptibility 1 or 2 genes.
authors.affiliation: Division of Gynecologic Oncology, Center for Human Genetics, Department of Genetics, University Hospitals of Cleveland, Western Reserve University, Ohio 44106, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Rose
authors.forename: R
authors.initials: R
authors.lastname: Shrigley
authors.forename: G L
authors.initials: GL
authors.lastname: Wiesner
mesh_terms: D024682:BRCA2 Protein; D002277:Carcinoma / Q000235:genetics*; D005185:Fallopian Tube Neoplasms / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D018095:Germ-Line Mutation; D006801:Humans; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D010375:Pedigree; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors