Extracorporeal membrane oxygenation support of donor abdominal organs in non-heart-beating donors.
Both family consent and legal consent were required for organ/tissue donation from non-heart-beating donors (NHBD) in Taiwan. A district attorney had to come to the bedside to confirm the donor's asystole, confirm the family consent, and complete some legal documents before a legal consent was issued for organ donation. The resultant warm ischemic time would be unpredictably long and in fact precluded the organ donation from NHBD in Taiwan. We developed a method of using extracorporeal membrane oxygenation (ECMO) to maintain NHBD for a longer time and prevent warm ischemic injury of the donor abdominal organs. After ventilator disconnection in NHBD, phentolamine and heparin were injected and mannitol infusion was given. After the donor's asystole was confirmed by the electrocardiogram (EKG) strip recording, the ECMO support was set up through the right femoral veno-arterial route, an occlusion balloon catheter was inserted through the left femoral artery to occlude the thoracic aorta, and bilateral femoral arteries were ligated. Usually, the ECMO could begin within 10 min after the donor's asystole. The ECMO, combined with a cooler, provided cold oxygenated blood to the abdominal visceral organs, and prevented their warm ischemic injuries. Under the ECMO support (range: 45-70 min), eight renal grafts were procured from 4 NHBD. With the exception of the first two renal grafts with delayed function, all others had immediate function postoperatively and dialysis was no longer needed. In conclusion, by our ECMO technique, NHBD could be maintained for a longer time and the renal grafts had better immediate postoperative function than those reported by other methods.
Ko
W J
WJ
Department of Surgery, National Taiwan University Hospital, Taipei.
Chen
Y S
YS
Tsai
P R
PR
Lee
P H
PH
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D002404:Catheterization; D017679:Cryotherapy; D004234:Diuretics, Osmotic / Q000008:administration & dosage; D004562:Electrocardiography; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007511:Ischemia / Q000517:prevention & control; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation / Q000502:physiology; D008297:Male; D008353:Mannitol / Q000008:administration & dosage; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D010646:Phentolamine / Q000008:administration & dosage; D020011:Protective Agents / Q000008:administration & dosage; D013624:Taiwan; D014019:Tissue Donors / Q000331:legislation & jurisprudence; D009927:Tissue and Organ Procurement / Q000331:legislation & jurisprudence
D000317:Adrenergic alpha-Antagonists; D000925:Anticoagulants; D004234:Diuretics, Osmotic; D020011:Protective Agents; D008353:Mannitol; D006493:Heparin; D010646:Phentolamine