title: Three new triterpenoids from Peganum nigellastrum.
abstract: Three new triterpenoids, 3alpha,27-dihydroxylup-20(29)-en-28-oic acid methyl ester, 3alpha-acetoxy-27-hydroxylup-20(29)-en-28-oic acid methyl ester, and 3alpha-acetoxyolean-12-ene-27,28-dioic acid 28-methyl ester, were isolated from the roots of Peganum nigellastrum along with four known lupene-type triterpenoids. The structures of the new triterpenoids were determined by NMR spectroscopic means. The new triterpene, 3alpha, 27-dihydroxylup-20(29)-en-28-oic acid methyl ester is a DNA topoisomerase II inhibitor (IC(50) = 8.9 microM/mL).
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, Miyama, Funabashi, Chiba 274-8510, Japan.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Ma
authors.forename: Y
authors.initials: Y
authors.lastname: Hano
authors.forename: T
authors.initials: T
authors.lastname: Nomura
authors.forename: Y J
authors.initials: YJ
authors.lastname: Chen
mesh_terms: D004250:DNA Topoisomerases, Type II / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D014315:Triterpenes; D004250:DNA Topoisomerases, Type II