The effect of steroid and intravenous immunoglobulin on thrombopoietin levels in pediatric patients with immune thrombocytopenic purpura.
Thrombopoietin (TPO), which is the main regulator of megakaryo/thrombopoiesis, has been recently cloned and purified, and shown to be useful in discriminating thrombocytopenia due to decreased production or increased platelet destruction. However, there are no detailed investigations about the drug effects on TPO levels during childhood. This study was conducted to measure the TPO levels of children with immune thrombocytopenic purpura (ITP) during steroid and immunoglobulin treatment. Twelve patients with acute ITP were treated with high-dose methyl prednisolone and five patients were treated with intravenous immunoglobulin. Neither steroids nor immunoglobulin were found to have any effect on TPO levels.
Koçak
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Department of Pediatrics, Kirikkale University Medical School, Turkey. fkocak@dialup.ankara.edu.tr
Gürsel
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Oztürk
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D000208:Acute Disease; D000284:Administration, Oral; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000494:pharmacology*; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy*; D013926:Thrombopoietin / Q000097:blood / Q000187:drug effects*; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D013926:Thrombopoietin; D008775:Methylprednisolone