title: Malathion deposition, metabolite clearance, and cholinesterase status of date dusters and harvesters in California.
abstract: Date gardens in the Coachella Valley in California typically receive multiple treatments of malathion to control major insect pests. Variable amounts of malathion dust retention by skin and clothing and individual work behaviors limit the usefulness of clothing as an exposure dosimeter in date dusters and harvesters. To determine malathion absorption in workers, urine clearance of dimethyl phosphates (alkyl phosphates; AP) and malathion mono- (MCA) and di- (DCA) acids were estimated from date dusters (loaders/applicators) and harvesters (both on ground and high in trees). A series of self-administered doses of malathion were either ingested in gelatin capsules or applied to the volar surface of the forearm to guide biomonitoring. Each of the dimethyl phosphates (dimethylthio> dimethyldithio > dimethyl-) and both malathion mono- and diacids were present in urine as soon as 2-3 h of work. On a micromole basis dimethylthiophosphate and the malathion acids (MCA > DCA) were the most prominent metabolites in urine. Applicator exposures ranged from 95-210 mg equivalents per day (1-3 mg/kg-day). Harvester exposures ranged from 1-270 microg/kg-day. Mid-season Monday morning urine specimens before work contained low or unmeasurable levels of malathion acids, indicating that malathion is rapidly metabolized and cleared from the body in the urine. Saliva was not useful for biomonitoring. No inhibition of cholinesterase activity was measured in any members of two separate crews of harvesters who had previous prolonged dust exposure (1 and 2 months).
authors.affiliation: Department of Entomology, University of California, Riverside 92521, USA.
authors.forename: R I
authors.initials: RI
authors.lastname: Krieger
authors.forename: T M
authors.initials: TM
authors.lastname: Dinoff
mesh_terms: D000383:Agriculture; D002140:California; D002648:Child; D002675:Child, Preschool; D002802:Cholinesterases / Q000378:metabolism*; D004391:Dust / Q000032:analysis; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007306:Insecticides / Q000493:pharmacokinetics*; D008294:Malathion / Q000493:pharmacokinetics*; D008297:Male; D016273:Occupational Exposure / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D012869:Skin Absorption
chemical_list: D004391:Dust; D007306:Insecticides; D010573:Pesticide Residues; D002802:Cholinesterases; D008294:Malathion