Chromosomal assignment of canine TSC2, PKD1 and CLN3 genes by radiation hybrid- and linkage analyses.
The canine tuberous sclerosis 2 (TSC2) gene has been mapped to canine chromosome 6 using a canine whole genome radiation hybrid panel. There is close linkage between canine TSC2 and the polycystic kidney disease 1 gene (PKD1), as has been observed in humans and other mammalian species. The gene responsible for the human juvenile form of neuronal ceroid lipofuscinosis (CLN3), maps close to TSC2 and PKD1 in humans, and is also syntenic in the dog. We further demonstrate linkage to a group of polymorphic markers assigned to canine chromosome 6 (CFA6).
Jónasdóttir
T J
TJ
Norwegian School of Veterinary Science, Department of Morphology, Genetics and Aquatic Biology, Oslo, Norway. tora.jonasdottir@veths.no
Mellersh
C S
CS
Moe
L
L
Vignaux
F
F
Ostrander
E A
EA
Lingaas
F
F
D000818:Animals; D002874:Chromosome Mapping / Q000662:veterinary; D002875:Chromosomes; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D016147:Genes, Tumor Suppressor; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D009472:Neuronal Ceroid-Lipofuscinoses / Q000235:genetics; D016891:Polycystic Kidney, Autosomal Dominant / Q000235:genetics / Q000662:veterinary*; D011506:Proteins / Q000235:genetics*; D012097:Repressor Proteins / Q000235:genetics*; D050396:TRPP Cation Channels; D014402:Tuberous Sclerosis / Q000235:genetics / Q000662:veterinary*; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D011506:Proteins; D012097:Repressor Proteins; D050396:TRPP Cation Channels; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; C105199:CLN3 protein, human; C000624653:TSC2 protein, human