Role of interleukin-8 in neutrophil signaling.
Interleukin-8 was originally discovered as one of the first chemokines activating neutrophil granulocytes (neutrophils) after secretion by lipopolysaccharide-stimulated monocytes. A wealth of information has been gathered concerning the intracellular events mediated by interleukin-8 and the role of interleukin-8 in numerous physiologic and pathophysiologic processes. We discuss recent advances in the understanding of the initial intracellular signals elicited by interleukin-8. Detailed investigation of these events has led to the identification of subtle but significant differences in the signal transduction processes evoked by interleukin-8 receptors. In particular, much has been learned concerning differences in the cellular mechanisms leading to desensitization, internalization, and recycling of interleukin-8 receptors, and functional consequences of interleukin-8 receptor diversity are now being unraveled.
Zeilhofer
H U
HU
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Erlangen, Germany. zeilhofer@pharmakologie.uni-erlangen.de
Schorr
W
W
D000818:Animals; D015703:Antigens, CD / Q000097:blood / Q000378:metabolism / Q000502:physiology; D018925:Chemokines / Q000097:blood / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D016209:Interleukin-8 / Q000097:blood / Q000494:pharmacology / Q000502:physiology*; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D018123:Receptors, Interleukin / Q000097:blood / Q000378:metabolism / Q000502:physiology; D023062:Receptors, Interleukin-8A; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D015703:Antigens, CD; D018925:Chemokines; D016209:Interleukin-8; D018123:Receptors, Interleukin; D023062:Receptors, Interleukin-8A