title: Molluscicidal saponins from Anagallis arvensis against schistosome intermediate hosts.
abstract: The molluscicidal activity of saponins isolated from the plant Anagallis arvensis (Primulaceae) was studied against schistosome intermediate hosts, Biomphalaria glabrata and Oncomelania quadrasi. @Strong molluscicidal activity was found in two compounds called desglucoanagalloside B and anagalloside B. Their structures were identified on the basis of chemical and spectroscopic analyses and their activities are comparable to that of the synthetic molluscicide, niclosamide.
authors.affiliation: Theodor Bilharz Research Institute, Giza, Egypt. mkawan@nih.go.jp
authors.forename: M M
authors.initials: MM
authors.lastname: Abdel-Gawad
authors.forename: S M
authors.initials: SM
authors.lastname: El-Amin
authors.forename: H
authors.initials: H
authors.lastname: Ohigashi
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Sugiyama
authors.forename: M
authors.initials: M
authors.lastname: Kawanaka
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008974:Mollusca / Q000187:drug effects* / Q000469:parasitology; D008975:Molluscacides / Q000737:chemistry*; D009534:Niclosamide / Q000737:chemistry / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D012547:Schistosoma; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes
chemical_list: D008975:Molluscacides; D012503:Saponins; D014315:Triterpenes; C411298:anagalloside B; C411297:desglucoanagalloside B; D009828:Oleanolic Acid; D009534:Niclosamide