title: Enantioresolution of aliphatic alcohols by lithocholamide.
abstract: Lithocholamide (LCAM) forms inclusion compounds with aliphatic alcohols involving over five carbon atoms. Enantioresolution of the racemic alcohols was studied in channels of the inclusion compounds. X-ray crystallographic study clarified that host assemblies exhibit guest-dependent polymorphism. In each polymorphic crystal, the more longer or bulkier groups the alcohols have, the effective the resolutions become. The inclusion spaces were analyzed by a computed tomographic method, explaining the chiral recognition mechanism from a stereochemical viewpoint.
authors.affiliation: Department of Material and Life Science, Graduate School of Engineering, Osaka University, Suita, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Aoki
authors.forename: Y
authors.initials: Y
authors.lastname: Hishikawa
authors.forename: K
authors.initials: K
authors.lastname: Sada
authors.forename: M
authors.initials: M
authors.lastname: Miyata
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008095:Lithocholic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; C408481:lithocholamide; D008095:Lithocholic Acid