title: Progressive outer retinal necrosis caused by herpes simplex virus type 1 in a patient with acquired immunodeficiency syndrome.
abstract: OBJECTIVE
  To identify the etiologic agent of rapidly progressive outer retinal necrosis (PORN) in a 32-year-old man with acquired immunodeficiency syndrome (AIDS), who had retinitis developed from cytomegalovirus (CMV). Multiple yellowish spots appeared in the deep retina without evidence of intraocular inflammation or retinal vasculitis, diagnosed clinically as PORN. Death occurred after failure of multiple organs.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Both globes were taken at autopsy, fixed in formalin, and examined histopathologically and immunohistochemically to identify causative agents in the retinal lesions.
  
  
  METHODS
  Immunohistochemistry.
  
  
  RESULTS
  All layers of the retina were severely damaged and contained focal calcification. Cytomegalic inclusion bodies were found in cells in the damaged retina of the right eye. Immunohistochemical studies for herpesviruses revealed the presence of CMV antigens in the right retina at the posterior pole and herpes simplex virus type 1 (HSV-1)-specific antigen in the periphery of both retinas. No varicella-zoster virus (VZV) antigen was detected in either retina.
  
  
  CONCLUSIONS
  PORN has been described as a variant of necrotizing herpetic retinopathy, occurring particularly in patients with AIDS. Although the etiologic agent has been reported to be VZV, HSV-1 can be an etiologic agent.
authors.affiliation: Department of Ophthalmology, Tokyo Medical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kashiwase
authors.forename: T
authors.initials: T
authors.lastname: Sata
authors.forename: Y
authors.initials: Y
authors.lastname: Yamauchi
authors.forename: H
authors.initials: H
authors.lastname: Minoda
authors.forename: N
authors.initials: N
authors.lastname: Usui
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Kurata
authors.forename: M
authors.initials: M
authors.lastname: Usui
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000473:pathology / Q000821:virology; D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D003587:Cytomegalovirus / Q000276:immunology; D017726:Cytomegalovirus Retinitis / Q000150:complications / Q000473:pathology / Q000821:virology; D018450:Disease Progression; D015828:Eye Infections, Viral / Q000209:etiology* / Q000473:pathology / Q000821:virology; D017809:Fatal Outcome; D006561:Herpes Simplex / Q000150:complications* / Q000473:pathology / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D015882:Retinal Necrosis Syndrome, Acute / Q000209:etiology* / Q000473:pathology / Q000821:virology
chemical_list: D000956:Antigens, Viral