title: A cytotoxic sesquiterpene caffeate from the liverwort Bazzanianovae-zelandiae.
abstract: Extracts of the liverwort Bazzania novae-zelandiae were cytotoxic, with selective activity against human tumor cell lines. Bioactivity-directed isolation work showed that the new compound naviculyl caffeate (1) was the main cytotoxin. This structure was confirmed by synthesis from the co-occurring sesquiterpene naviculol (2).
authors.affiliation: Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Limited, Department of Chemistry, University of Otago, Dunedin, New Zealand.
authors.forename: E J
authors.initials: EJ
authors.lastname: Burgess
authors.forename: L
authors.initials: L
authors.lastname: Larsen
authors.forename: N B
authors.initials: NB
authors.lastname: Perry
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009520:New Zealand; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002109:Caffeic Acids; C409631:naviculyl caffeate