Disseminated metastasis of neuroblastomatous component in immature mediastinal teratoma: a case report.
A 17-year-old man with high levels of serum AFP and hCG was diagnosed as having primary mediastinal GCT. Cisplatin-based chemotherapy decreased the biomarkers, but the mass showed further growth. Pathological examination of the resected mass revealed a mixture of immature and mature teratomas. Six months after the surgery, the patient died of a dissemination of neuroblastomatous cells, which were similar to those in the immature neural component of the primary tumor. A disseminated metastasis of neuroblastoma in immature mediastinal teratoma is a rare complication. Serum NSE can be a useful marker in detecting the metastasis.
Ohtsuka
M
M
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan. m-otsuka@md.tsukuba.ac.jp
Satoh
H
H
Inoue
M
M
Yazawa
T
T
Yamashita
Y T
YT
Sekizawa
K
K
Hasegawa
S
S
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001761:Bleomycin / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary*; D019070:Cell Lineage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D008479:Mediastinal Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009447:Neuroblastoma / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012888:Skull Neoplasms / Q000473:pathology / Q000556:secondary; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013953:Thymus Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014747:Vinblastine / Q000008:administration & dosage
D014408:Biomarkers, Tumor; D001761:Bleomycin; D014747:Vinblastine; D010751:Phosphopyruvate Hydratase; D002945:Cisplatin