IL-18 in pregnancy; the elevation of IL-18 in maternal peripheral blood during labour and complicated pregnancies.
Serum interleukin-18 (IL-18) levels were measured in women in different trimesters of pregnancy, in labour, puerperium and in various complicated pregnancies. There was a significant elevation of IL-18 levels in pregnant sera from the first trimester until the onset of labour. Once labour began, IL-18 levels increased further and remained until at least the third day of puerperium. The high levels of IL-18 in sera were also observed in various complicated pregnancies, such as premature rupture of membranes (PROM), acute fatty liver of pregnancy and fetal growth restriction. IL-18 is likely to play a role in pregnancy.
Ida
A
A
Department of Obstetrics and Gynecology, Hyogo College of Medicine, 1-1 Mukogawa-Cho, Nishinomiya, Japan.
Tsuji
Y
Y
Muranaka
J
J
Kanazawa
R
R
Nakata
Y
Y
Adachi
S
S
Okamura
H
H
Koyama
K
K
D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D007743:Labor, Obstetric / Q000097:blood / Q000276:immunology*; D010146:Pain / Q000097:blood / Q000276:immunology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000276:immunology*; D011264:Pregnancy Trimesters
D020382:Interleukin-18