title: Angiomatoid Spitz nevus: a distinct variant of desmoplastic Spitz nevus with prominent vasculature.
abstract: Five cases of a distinctive variant of desmoplastic Spitz nevus are reported. To the best of our knowledge, this tumor has never been described previously. Clinically, it presents itself as a solitary papule on the extremities of young adults. Microscopically, it shows predominance of solitary melanocytes with epithelioid appearance over cell nests. They are embedded in a prominent fibrous stroma with many densely arranged, small blood vessels with plump endothelia not seen in other Spitz nevi. Because of its resemblance to a vascular tumor, the name angiomatoid Spitz nevus is proposed for this lesion. Absence of recurrences or metastases after complete excision in all cases supports the benign nature of the tumor.
authors.affiliation: Center for Dermatopathology, Freiburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Diaz-Cascajo
authors.forename: S
authors.initials: S
authors.lastname: Borghi
authors.forename: W
authors.initials: W
authors.lastname: Weyers
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008544:Melanocytes / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D018332:Nevus, Epithelioid and Spindle Cell / Q000098:blood supply / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor