Basal and reserve renal artery blood flow: effect of endothelium-dependent and -independent vasoactive agonists and radiographic contrast medium in two patients.
This manuscript describes the results of invasive testing of renal artery and arteriolar reactivity in two patients using a panel of endothelium-dependent and -independent agents including radiographic contrast medium. We found that the renal artery and microcirculation dilate in response to graded acetylcholine infusions and to bolus nitroglycerin infusion; the renal microcirculation dilates in response to papaverine but constricts after adenosine and after radiographic contrast medium. Future indications for this testing are briefly discussed.
Houghton
J L
JL
Division of Cardiology, Department of Medicine, Albany Medical College, NY 12208, USA. Houghtj@mail.amc.edu
Cerda
J
J
Smith
V E
VE
D000109:Acetylcholine / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D006328:Cardiac Catheterization; D003287:Contrast Media / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects; D005260:Female; D006801:Humans; D007472:Iohexol / Q000494:pharmacology*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology; D012077:Renal Artery / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D003287:Contrast Media; D014665:Vasodilator Agents; D007472:Iohexol; D010208:Papaverine; D005996:Nitroglycerin; D000109:Acetylcholine