title: Beta-adrenoceptor inhibition for induction of acute cardiac failure in pigs.
abstract: For the testing of heart assist devices most animal models of acute cardiac failure that are usually used show certain disadvantages. We therefore developed a new method using the beta-adrenoceptor antagonist carazolol. We administered a bolus injection of 1 mg/kg followed by a continuous infusion of 1 mg/kg/h in adult German 'Landrasse' pigs. Blood pressure, heart rate, cardiac output and maximum left ventricular pressure rise time showed a significant (P < 0.05) reduction of the control value varying between 40% and 59%. The method is suitable for the testing of surgical approaches in heart failure.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Heinrich-Heine-Universität Düsseldorf, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Petzold
authors.forename: P
authors.initials: P
authors.lastname: Feindt
authors.forename: M D
authors.initials: MD
authors.lastname: Menger
authors.forename: E
authors.initials: E
authors.lastname: Gams
mesh_terms: D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D011412:Propanolamines / Q000633:toxicity*; D013552:Swine
chemical_list: D000319:Adrenergic beta-Antagonists; D011412:Propanolamines; C014382:carazolol