[The effect of semax and mexidol on the course of acute pancreatitis in rats].
The effect of semax and mexidol on the course of acute pancreatitis in rats was studied in comparison with the action of contrical, fluorouracil, and dibunol. It was established that a single intraductal or intraperitoneal administration of semax or mexidol markedly reduces the loss of experimental animals (to 10-13%), decreases hyperfermentemia, lipid peroxidation activation, and vascular permeability, improves microcirculation, and accelerates healing of the damaged pancreatic zones by substitutional repair of pancreatic acini not accompanied by coarse fibrous changes in the parenchyma. Upon the intraductal administration, semax and mexidol were more effective than contrical, fluorouracil, and dibunol.
Ivanov
Iu V
IuV
Department of Pharmacology, Gidrobios Research and Production Center, Ministry of Public Health of the Russian Federation, Moscow, Russia.
Iasnetsov
V V
VV
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005472:Fluorouracil / Q000627:therapeutic use; D008297:Male; D018697:Nootropic Agents / Q000627:therapeutic use*; D010195:Pancreatitis / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D010446:Peptide Fragments / Q000627:therapeutic use*; D010847:Picolines / Q000627:therapeutic use*; D051381:Rats
D000975:Antioxidants; D018697:Nootropic Agents; D010446:Peptide Fragments; D010847:Picolines; D002084:Butylated Hydroxytoluene; C070020:emoxypine succinate; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D007611:Aprotinin; D005472:Fluorouracil