Transplantation and 2-year follow-up of kidneys procured from a cadaver donor with a history of lupus nephritis.
BACKGROUND
Two patients underwent cadaver transplantation with kidneys from a donor with a history of World Health Organization Class IV/V lupus nephritis, and we report their clinical and pathological outcome.


METHODS
The donor had a diagnosis of lupus nephritis made by renal biopsy 5 years before donation. At the time of donation, a biopsy was performed on the donor and on one of the recipients at 2 months and 1 year after the transplant.


RESULTS
Both recipients underwent uneventful renal transplantation. On the first postoperative day, the donor's final pathological results became available. Although the frozen section seemed to be quite benign, the permanent sections revealed World Health Organization Class II/V lupus nephritis, with full house immunofluorescence and multiple electron dense deposits. Biopsies were performed on recipient #2 at 8 weeks and 1 year after the transplant. These revealed marked diminution followed by complete resolution of all tubular reticular structures and deposits as well as immunofluorescent activity. Both recipients remain with normal renal function and urinalysis at 3 years after the transplant.


CONCLUSIONS
Although a history of clinically significant renal disease has been considered an absolute contraindication to kidney donation, with appropriate workup and caution, select patients may still be considered, which would increase the potential donor pool.
Lipkowitz
G S
GS
Department of Surgery, Baystate Medical Center, Springfield, MA 01199, USA.
Madden
R L
RL
Kurbanov
A
A
Mulhern
J G
JG
O'Shea
M H
MH
Germain
M J
MJ
Freeman
J
J
Braden
G L
GL
D000328:Adult; D001706:Biopsy; D002102:Cadaver; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007483:Iothalamic Acid / Q000378:metabolism; D007668:Kidney / Q000473:pathology / Q000502:physiology; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000473:pathology; D008181:Lupus Nephritis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D014019:Tissue Donors; D009927:Tissue and Organ Procurement / Q000639:trends; D016482:Urinalysis
D007483:Iothalamic Acid; D003404:Creatinine