Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure.
This report describes the synthesis and the transfection properties of novel monocationic non-toxic lipids. We have carried out structural variations in all three units of the transfection lipid, the lipid anchor, the spacer moiety and the positively charged head group. Our results lead to the conclusion that systematic modification of structural subunits is a promising way to enhance the transfection efficiency.
Fichert
T
T
Tumor Biology Center, Department of Clinical Research, Freiburg, Germany.
Regelin
A
A
Massing
U
U
D000818:Animals; D019556:COS Cells; D008055:Lipids / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D014162:Transfection
D008055:Lipids