title: Atypical fibroxanthoma with osteoclast-like multinucleated giant cells.
abstract: Atypical fibroxanthoma (AF) is generally considered as a low grade superficial variant of fibrohistiocytic neoplasm. In this report we present an unusual variant of this neoplasm arising from actinic damaged skin of an elderly individual. The case was characterized by numerous multinucleated osteoclast-like giant cells uniformly scattered through a pleomorfic cellular proliferation. The osteoclasts giant cell observed represent multinucleated histiocytes rather than true osteoclasts.
authors.affiliation: IV Cattedra di Anatomia ed Istologia Pathologica, II Università di Napoli, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Ferrara
authors.forename: G
authors.initials: G
authors.lastname: Baldi
authors.forename: M P
authors.initials: MP
authors.lastname: Di Marino
authors.forename: G
authors.initials: G
authors.lastname: Bellucci
authors.forename: A
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000199:Actins / Q000032:analysis; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000473:pathology; D006644:Histiocytes / Q000473:pathology*; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009113:Muramidase / Q000032:analysis; D009130:Muscle, Smooth / Q000737:chemistry; D010010:Osteoclasts / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D000199:Actins; D009418:S100 Proteins; D009113:Muramidase