Vancomycin and oxacillin synergy for methicillin-resistant staphylococci.
An increase in oxacillin activity was observed against methicillin-resistant coagulase-negative staphylococci (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) in the presence of a sub-MIC of vancomycin. Vancomycin and oxacillin were synergistic against 14 of 21 strains of MRCNS and MRSA. A pattern of enhanced killing was also supported by time-kill studies. These results suggest that combinations of sub-MICs of vancomycin and oxacillin may have therapeutic benefits against methicillin-resistant staphylococci.
Domaracki
B E
BE
Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, New York 12208, USA.
Evans
A M
AM
Venezia
R A
RA
D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D016106:Methicillin Resistance / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects*; D013997:Time Factors; D014640:Vancomycin / Q000494:pharmacology*
D014640:Vancomycin; D010068:Oxacillin