title: Exudative retinal detachment and retinitis associated with acquired syphilitic uveitis.
abstract: OBJECTIVE
  To describe three cases of exudative retinal detachment and focal retinitis associated with acquired syphilitic uveitis.
  
  
  METHODS
  Three patients who were referred for evaluation of uveitis were examined. Slit-lamp examination, ophthalmoscopy, B-scan ultrasonography, fundus photography, and fluorescein angiography were performed before and after therapy.
  
  
  RESULTS
  Each patient had uveitis with exudative retinal detachment, periphlebitis, and focal retinitis. Laboratory testing (fluorescent treponemal antibody absorption) revealed positive serology for active syphilis in all cases. Human immunodeficiency virus antibody testing was negative in all patients. Retinal detachment resolved in all cases after treatment with intravenous penicillin. Despite resolution of subretinal fluid, visual acuity remained poor in eyes in which the macula was detached.
  
  
  CONCLUSIONS
  Syphilis is a cause of exudative retinal detachment. Antibiotic therapy can lead to retinal reattachment. Early recognition and treatment may prevent severe vision loss.
authors.affiliation: Department of Ophthalmology, Wilford Hall Medical Center, Lackland Air Force Base, Texas, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Jumper
authors.forename: R
authors.initials: R
authors.lastname: Machemer
authors.forename: R P
authors.initials: RP
authors.lastname: Gallemore
authors.forename: G J
authors.initials: GJ
authors.lastname: Jaffe
mesh_terms: D000328:Adult; D000368:Aged; D005122:Exudates and Transudates; D015818:Eye Infections, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D012163:Retinal Detachment / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012173:Retinitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013587:Syphilis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013588:Syphilis Serodiagnosis; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity
chemical_list: D005938:Glucocorticoids; D010406:Penicillins; D010400:Penicillin G; D011241:Prednisone