title: Alobar holoprosencephaly at 9 weeks gestational age visualized by two- and three-dimensional ultrasound.
abstract: We present the ultrasound detection of alobar holoprosencephaly (HPE) with cyclopia in an embryo of 9 weeks 2 days last menstrual period (LMP)-based gestational age; the crown-rump length (CRL) was 22 mm. The use of three-dimensional (3-D) ultrasound made additional diagnostic ultrasound tomograms possible, and the volume reconstructions improved the imaging and the understanding of the condition.
authors.affiliation: National Center for Fetal Medicine, Trondheim University Hospital, Norwegian University of Science and Technology, Norway.
authors.forename: H G
authors.initials: HG
authors.lastname: Blaas
authors.forename: S H
authors.initials: SH
authors.lastname: Eik-Nes
authors.forename: T
authors.initials: T
authors.lastname: Vainio
authors.forename: C V
authors.initials: CV
authors.lastname: Isaksen
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D001344:Autopsy; D018568:Crown-Rump Length; D005260:Female; D005865:Gestational Age; D016142:Holoprosencephaly / Q000000981:diagnostic imaging* / Q000196:embryology / Q000235:genetics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007621:Karyotyping; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016216:Ultrasonography, Prenatal / Q000295:instrumentation / Q000379:methods*