title: A case of multiple myeloma which developed into multiple extramedullary involvement in the terminal stage.
abstract: A 69-year-old man with a diagnosis of multiple IgG class myeloma received combination chemotherapy. He achieved a partial response with an undetected M spike. However, he demonstrated new lytic bone lesions and multiple extramedullary involvement 10 months after the initial presentation. Polymerase chain reaction (PCR) analysis using a framework 3 (Fr3) V-region primer clarified a discrete band in the extramedullary tumor, while it yielded 4 bands including the same size as the extramedullary tumor produced in the bone marrow sample obtained before the chemotherapy. These findings suggest that a resistant and non-secretory clone was selected by the combination chemotherapy.
authors.affiliation: Department of Internal Medicine, Saga Prefectural Hospital.
authors.forename: Y
authors.initials: Y
authors.lastname: Umeno
authors.forename: K
authors.initials: K
authors.lastname: Kogawa
authors.forename: E
authors.initials: E
authors.lastname: Matsuishi
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Torii
authors.forename: K
authors.initials: K
authors.lastname: Irie
authors.forename: M
authors.initials: M
authors.lastname: Kanda
authors.forename: K
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000368:Aged; D064211:Connectin; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D009101:Multiple Myeloma / Q000473:pathology*; D009124:Muscle Proteins; D009194:Myeloma Proteins / Q000032:analysis; D016133:Polymerase Chain Reaction
chemical_list: D064211:Connectin; D007074:Immunoglobulin G; D009124:Muscle Proteins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins