A new method for the synthesis of N3-alkylated analogs of 5-fluorouracil.
5-Fluorouracil (5-FU) is converted to the adducts 1a,b then subjected to Mitsunobu reaction with the secondary alcohols to give the condensates 2a,b. Hydrogenation of 2a,b with Pd/C affords N3-alkyl-5-fluorouracil 3a,b.
Kozai
S
S
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Fukagawa
T
T
Maruyama
T
T
D000478:Alkylation; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation
D007202:Indicators and Reagents; D005472:Fluorouracil