Bone marrow hypoplasia associated with acute viral hepatitis in four children.
Four cases of children, aged 2 to 11 years, with acute viral hepatitis and bone marrow hypoplasia are reported. Three patients presented only jaundice and hepatomegaly; one also had liver failure. All the four patients underwent bone marrow aspiration which showed bone marrow aplasia. In two of the four patients a liver biopsy revealed patchy necrosis with inflammatory mononuclear cell infiltrate. Half of the patients received a bone marrow transplantation; the remaining patients were treated by intravenous infusion of immunoglobulins, growth factors and steroids. The main epidemiological and etiological features of such association are also reported.
Pavone
P
P
Clinica Pediatrica I, Università degli Studi, Catania.
Greco
F
F
Fisher
A
A
Zancan
L
L
D'Agata
A
A
Musumeci
S
S
D001706:Biopsy; D001855:Bone Marrow Diseases / Q000628:therapy* / Q000821:virology*; D016026:Bone Marrow Transplantation / Q000379:methods; D002648:Child; D002675:Child, Preschool; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008297:Male
D016756:Immunoglobulins, Intravenous