[Animal experiment studies on the effectiveness of permanent occlusion of the hepatic artery in transarterial chemoembolization].
OBJECTIVE
To evaluate the effect of permanent occlusion of the hepatic artery on the efficacy of transarterial chemoembolization (TACE) in an animal model.


METHODS
12 days after inoculation of the Morris hepatoma 3924 A in 15 male ACI rats, TACE with Mitomycin C (0.25 mg/kgBW) + Lipiodol (0.2 ml/kgBW) without (n = 5) and with permanent occlusion of the hepatic artery (n = 5) was performed. Control group consisted of 5 rats. Tumor volume was determined by MRI (1.0 T, T1 [TR/TE, 400/14 ms]) before and 12 days after therapy.


RESULTS
Compared to the control group, TACE without and with permanent occlusion of the hepatic artery showed a significant reduced tumor growth after 12 days (p = 0.017 and p = 0.005). However, permanent occlusion did not improve the retarding effect on tumor growth (p = 0.9).


CONCLUSIONS
The effectiveness of TACE in an animal model using a cytostatic-/lipiodol-emulsion is not improved by permanent occlusion of the hepatic artery.
Trübenbach
J
J
Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität Tübingen. jochen.truebenbach@med.uni-tuebingen.de
Pereira
P L
PL
Graepler
F
F
Huppert
P E
PE
Eul
T
T
König
C W
CW
Duda
S H
SH
Claussen
C D
CD
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D003627:Data Interpretation, Statistical; D004655:Emulsions; D006499:Hepatic Artery; D007459:Iodized Oil / Q000008:administration & dosage; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D016685:Mitomycin / Q000008:administration & dosage; D051381:Rats
D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D004655:Emulsions; D016685:Mitomycin; D007459:Iodized Oil