Molluscicidal saponins from Anagallis arvensis against schistosome intermediate hosts.
The molluscicidal activity of saponins isolated from the plant Anagallis arvensis (Primulaceae) was studied against schistosome intermediate hosts, Biomphalaria glabrata and Oncomelania quadrasi. @Strong molluscicidal activity was found in two compounds called desglucoanagalloside B and anagalloside B. Their structures were identified on the basis of chemical and spectroscopic analyses and their activities are comparable to that of the synthetic molluscicide, niclosamide.
Abdel-Gawad
M M
MM
Theodor Bilharz Research Institute, Giza, Egypt. mkawan@nih.go.jp
El-Amin
S M
SM
Ohigashi
H
H
Watanabe
Y
Y
Takeda
N
N
Sugiyama
H
H
Kawanaka
M
M
D000818:Animals; D001700:Biomphalaria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008974:Mollusca / Q000187:drug effects* / Q000469:parasitology; D008975:Molluscacides / Q000737:chemistry*; D009534:Niclosamide / Q000737:chemistry / Q000494:pharmacology; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D012547:Schistosoma; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014315:Triterpenes
D008975:Molluscacides; D012503:Saponins; D014315:Triterpenes; C411298:anagalloside B; C411297:desglucoanagalloside B; D009828:Oleanolic Acid; D009534:Niclosamide