title: [Current data on the extrarenal renin-angiotensin system].
abstract: After a brief historical incursion regarding SRA of renal origin we present the main extrarenal angiotensin-forming enzymes, starting with isorenin, tonin, cathepsin D şi G and ending with the conversion enzyme and chymase. This is followed by a short presentation of data concerning tissue SRA in the heart and vessels, brain and neurocranial accessory glands, cortico-suprarenalian and gonadal glandular territory. In the end we refer to the relations between circulating SRA of renal origin and the tissue extrarenal one, underlying the fact that the two SRA components cooperate and constitute a unitary hormonal system, towards the regulation of the major functions of the organism and the maintenance of the main homeostatic equilibria. While the circulating SRA of renal origin is acutely activated to contribute to the accomplishment of short term homeostatic reactions, tissue SRA, in paracrine or autocrine ways, exerts loco-regional adaptive actions of long duration.
authors.affiliation: Disciplina de Fiziologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
authors.forename: I
authors.initials: I
authors.lastname: Haulică
authors.forename: G
authors.initials: G
authors.lastname: Petrescu
authors.forename: S
authors.initials: S
authors.lastname: Slătineanu
authors.forename: W
authors.initials: W
authors.lastname: Bild
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000502:physiology; D001921:Brain / Q000502:physiology; D005260:Female; D006321:Heart / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000502:physiology; D008297:Male; D010053:Ovary / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology*; D013737:Testis / Q000502:physiology