title: Short-term exposure to air pollution in a road tunnel enhances the asthmatic response to allergen.
abstract: The aim of this study was to assess whether air pollution in road tunnels would promote asthmatic reactions in persons with mild allergic asthma. Twenty volunteers with mild allergic asthma were exposed, inside a car, for 30 min in a Stockholm city road tunnel. As a control, the subjects were exposed to much lower pollution levels in a suburban area. Four hours after the exposure, the subjects inhaled a low dose of allergen. Asthmatic reaction during the early phase was measured as the increase in specific airway resistance 15 min after allergen inhalation and during the late phase as the decrease in lung function forced expiratory volume in one second 3-10 h after allergen inhalation. Asthma symptoms and drug use were monitored up to 18 h after allergen inhalation. The median nitrogen dioxide level during exposure was 313 microg x m-3 (range 203-462). The median levels of particles with 50% cut-off aerodynamic diameters of 10 (PM10) and 2.5 microm (PM2.5) were 170 (range 103-613) and 95 (range 61-218) micro x m-3, respectively. Subjective symptoms during tunnel exposure were not pronounced. However, subjects exposed to tunnel N02 levels of > or = 300 microg x m-3 had a significantly greater early reaction, following allergen exposure, as well as lower lung function and more asthma symptoms during the late phase, compared to control. Also, subjects with PM2.5 exposure > or = 100 microg x m-3 had a slightly increased early reaction compared to control. In conclusion, exposure to air pollution in road tunnels may significantly enhance asthmatic reactions to subsequently inhaled allergens.
authors.affiliation: Dept of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Svartengren
authors.forename: V
authors.initials: V
authors.lastname: Strand
authors.forename: G
authors.initials: G
authors.lastname: Bylin
authors.forename: L
authors.initials: L
authors.lastname: Järup
authors.forename: G
authors.initials: G
authors.lastname: Pershagen
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D000403:Airway Resistance / Q000502:physiology; D001249:Asthma / Q000209:etiology* / Q000503:physiopathology; D001334:Automobile Driving; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000009:adverse effects; D010991:Plethysmography; D012016:Reference Values; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013997:Time Factors; D001335:Vehicle Emissions / Q000009:adverse effects*
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions; D009569:Nitric Oxide