Macrocarpins A-D, new cytotoxic nor-triterpenes from Maytenus macrocarpa.
Macrocarpins A (1), B (2), C (3) and D (4), four new nor-triterpenes, have been isolated from the roots of Maytenus macrocarpa. The structures were established by spectroscopic examinations. Natural compounds 1, 2, 4 and the acetyl derivative 1a are cytotoxic against four tumoral cell lines with IC50 values ranging between 0.4 and 5.2 microM.
Chávez
H
H
Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Tenerife, Spain.
Rodríguez
G
G
Estévez-Braun
A
A
Ravelo
A G
AG
Estévez-Reyes
R
R
González
A G
AG
Fdez-Puente
J L
JL
García-Grávalos
D
D
D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D013057:Spectrum Analysis; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
D014315:Triterpenes