Propofol-associated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings.
Propofol, a central-acting sedative agent, has been implicated in the development of rhabdomyolysis in children. We describe two adults who developed rhabdomyolysis after receiving high rates of propofol infusion. Rhabdomyolysis of both skeletal and cardiac muscle was suggested in both patients by marked increases of creatine kinase (>170 000 U/L) and cardiac troponin I (11 and 46 microg/L in patients one and two, respectively). Creatine kinase and cardiac troponin I values were highly correlated in each patent (r = 0.786 and 0.988 in patients one and two, respectively). Autopsy of one patient confirmed the diagnosis of skeletal and cardiac rhabdomyolysis.
Stelow
E B
EB
Department of Laboratory Medicine and Pathology, Hennepin County Medical Center, Minneapolis, MN 55415, USA.
Johari
V P
VP
Smith
S A
SA
Crosson
J T
JT
Apple
F S
FS
D000328:Adult; D015415:Biomarkers / Q000097:blood; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D015742:Propofol / Q000009:adverse effects*; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D019210:Troponin I / Q000097:blood
D015415:Biomarkers; D006993:Hypnotics and Sedatives; D019210:Troponin I; D003402:Creatine Kinase; D015742:Propofol