[Participation of intracerebral monoamines in intracellular processes in the neocortex neurons].
Using complex of modern methods including histochemical and immunocystochemical ones, the reactions of monoaminergic pyramidal neurons to the injury of afferent inputs were for the first time established to be differently directed including dysadaptive reorganizations, death of part of the pyramidal neurons of layers II-III and adaptive reactions of cells of the same type of layers V-VI. Neuron death was different from apoptosis and from well known "dark" type of degeneration which suggests a special mechanism of monoamine induced death of neurons. Previously undescribed intranuclear inclusions in the form of vacuoles, vesicles, myelin-like and fibrillar bodies and filament bundles were detected in pyramidal neurons that react to the injury of monoaminergic systems. Nuclear, nucleolar and cytoplasmic reorganizations that are also present are indicative of the participation of monoamines in regulation of such intracellular processes as nucleolar activity, intensity of transcription and processing as well as of nucleo-cytoplasmic transport. These mechanisms mediate regulatory influences of monoaminergic systems on functional activity of main efferent neocortical neurons that participate in regulation of many CNS functions. The experimental phenomenon of selective sensitivity and death of the part of pyramidal neurons obtained for the first time is considered as a model for studying the pathogenesis of certain psychoneurological diseases, caused by monoamine deficiency.
Otellin
V A
VA
Department of Morphology, Russian Academy of Medical Sciences, St. Petersburg.
Neokesariĭskiĭ
A A
AA
Korzhevskiĭ
D E
DE
D015116:5,7-Dihydroxytryptamine; D018663:Adrenergic Agents; D000818:Animals; D017209:Apoptosis; D015306:Biogenic Monoamines / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D019579:Neocortex / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D016627:Oxidopamine; D017966:Pyramidal Cells / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D018490:Serotonin Agents
D018663:Adrenergic Agents; D015306:Biogenic Monoamines; D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D016627:Oxidopamine