Genetic subtypes of HIV type 1 in Hungary.
We examined the diversity of HIV-1 subtypes in 11 adults from Hungary, using the heteroduplex mobility assay (HMA) and DNA sequencing. HMA results showed that HIV-1 gp120 sequences from 10 patients were of subtype B, whereas 1 patient, infected in Africa, carried a subtype C strain. DNA sequencing confirmed the HMA results and revealed a high intrasubtype diversity in the C2V3 region of env in different clade B isolates, which suggests multiple introduction of subtype B to Hungary. This study shows that subtype B is the predominant HIV-1 clade in Hungary.
Mezei
M
M
Microbiological Research Group, National Center for Epidemiology, Budapest, Hungary.
Balog
K
K
Takács
M
M
Tóth
G
G
Gyuris
A
A
Segesdi
J
J
Bakos
A
A
Vödrös
D
D
Bánhegyi
D
D
Berencsi
G
G
Minárovits
J
J
D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000821:virology; D000328:Adult; D000595:Amino Acid Sequence; D016384:Consensus Sequence; D004279:DNA, Viral / Q000235:genetics*; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000737:chemistry / Q000235:genetics*; D020180:Heteroduplex Analysis; D006716:Homosexuality; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D011533:Proviruses / Q000235:genetics; D016415:Sequence Alignment
D004279:DNA, Viral; D015699:HIV Envelope Protein gp120