CD14, new aspects of ligand and signal diversity.
The glycosyl-phosphatidylinositol-linked glycoprotein CD14 is expressed in myeloid cells and serum. It binds Gram-negative and -positive bacterial cell wall components and endogenous phospholipids. Toll-like receptors, NF-kappaB and MAP kinases participate in CD14 signaling of inflammation. Alterations of CD14 in inflammatory diseases support a pathogenic role for this microbial receptor.
Landmann
R
R
Division of Infectious Diseases, Departments of Research and Internal Medicine, University Hospital, Hebelstrasse 20, 4031, Basel, Switzerland.
Müller
B
B
Zimmerli
W
W
D000818:Animals; D016466:CHO Cells; D002462:Cell Membrane / Q000276:immunology; D006224:Cricetinae; D029721:Drosophila Proteins; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D008024:Ligands; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology; D012772:Shock, Septic / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D018746:Systemic Inflammatory Response Syndrome / Q000276:immunology; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008024:Ligands; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors