title: Cutaneous capillary hemangiomas of the eyelid, scalp, and digits in premature triplets.
abstract: OBJECTIVE
  To document the unique occurrence of multiple cutaneous capillary hemangiomas in healthy triplets.
  
  
  METHODS
  Case reports.
  
  
  RESULTS
  Triplets born 6 weeks prematurely were noted at birth to have classic cutaneous capillary hemangiomas that enlarged in the first few months of life. At 3 months of age, triplet #1 manifested a small capillary hemangioma on the left index finger and a large hemangioma that involved the entire left upper eyelid and completely occluded the visual axis. Triplet #2 had a small hemangioma on the thumb and a large hemangioma on the scalp of the forehead. Triplet #3 displayed only a minor hemangioma of the right upper eyelid that did not threaten her vision. The parents of the triplets admitted having a history of periocular capillary hemangioma that spontaneously resolved. Triplet #1 was managed with oral corticosteroids, with dramatic regression of the mass and exposure of the visual axis.
  
  
  CONCLUSIONS
  Cutaneous capillary hemangioma is usually a sporadic condition. We found this tumor in premature triplets whose parents had a history of a similar tumor. This suggests that hereditary and environmental factors may play a role in the development of this tumor. We advise that medical and family histories be obtained in all children with cutaneous capillary hemangioma.
authors.affiliation: Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: R
authors.initials: R
authors.lastname: Minzter
authors.forename: A D
authors.initials: AD
authors.lastname: Singh
mesh_terms: D005143:Eyelids; D005260:Female; D005385:Fingers; D005865:Gestational Age; D005938:Glucocorticoids / Q000627:therapeutic use; D018324:Hemangioma, Capillary / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D012535:Scalp; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D014310:Triplets
chemical_list: D005938:Glucocorticoids