Collection of fetal stem cells and newborn effects.
The aim of this work was to test fetal stem cells (FSC) number modification in relation to clamping time and newborn effect. The results show that a fast sample, between 20 and 40 seconds, from umbilical cord after fetus birth and before placental detachment assured a greater quantity of blood useful for the transplants; and that it was necessary to enrich the collected blood in CD34+ cells with specific clonogenic culture, as this is otherwise a small number for a donation to an adult. In the "new donors" the effects of the unconscious donation always depend on the clamping time, which should be the shortest possible to avoid blood overload, which is very dangerous in the presence of heart malformation.
Pafumi
C
C
Microbiology and Gynaecology Science Department, S. Bambino Hospital, University of Catania, Italy.
Milone
G
G
Todaro
A M
AM
Carbonaro
A
A
Pernicone
G
G
Bandiera
S
S
Russo
A
A
D018952:Antigens, CD34 / Q000032:analysis; D001800:Blood Specimen Collection / Q000379:methods*; D001810:Blood Volume; D003250:Constriction; D005333:Fetus / Q000502:physiology*; D006400:Hematocrit; D006801:Humans; D013234:Stem Cells; D013997:Time Factors
D018952:Antigens, CD34