In vitro activities of telithromycin (HMR 3647) against Rickettsia rickettsii, Rickettsia conorii, Rickettsia africae, Rickettsia typhi, Rickettsia prowazekii, Coxiella burnetii, Bartonella henselae, Bartonella quintana, Bartonella bacilliformis, and Ehrlichia chaffeensis.
In vitro activities of telithromycin compared to those of erythromycin against Rickettsia spp., Bartonella spp., Coxiella burnetii, and Ehrlichia chaffeensis were determined. Telithromycin was more active than erythromycin against Rickettsia, Bartonella, and Coxiella burnetii, with MICs of 0.5 microg/ml, 0.003 to 0.015 microg/ml, and 1 microg/ml, respectively, but was inactive against Ehrlichia chaffeensis.
Rolain
J M
JM
Unité des Rickettsies, CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
Maurin
M
M
Bryskier
A
A
Raoult
D
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001473:Bartonella / Q000187:drug effects*; D018416:Bartonella henselae / Q000187:drug effects; D018413:Bartonella quintana / Q000187:drug effects; D016997:Coxiella burnetii / Q000187:drug effects; D018469:Ehrlichia chaffeensis / Q000187:drug effects*; D006801:Humans; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D012281:Rickettsia / Q000187:drug effects*; D020114:Rickettsia conorii / Q000187:drug effects; D012283:Rickettsia prowazekii / Q000187:drug effects; D012284:Rickettsia rickettsii / Q000187:drug effects; D012286:Rickettsia typhi / Q000187:drug effects
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C106791:telithromycin