title: Prenylated benzoic acid derivatives from Ferula kuhistanica.
abstract: Four new prenylated benzoic acid derivatives, kuhistanols A-D (1-4), along with one known compound, 3-farnesyl-p-hydroxybenzoic acid (5), have been isolated from the roots of the Uzbekistan medicinal plant, Ferula kuhistanica. Their structures were established on the basis of chemical and spectral evidence. Compound 4 showed a significant inhibitory effect on cytokine production in lipopolysaccharide-stimulated human peripheral mononuclear cells.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: K
authors.initials: K
authors.lastname: Kawazoe
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: G
authors.initials: G
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: O K
authors.initials: OK
authors.lastname: Kodzhimatov
authors.forename: O
authors.initials: O
authors.lastname: Ashurmetov
mesh_terms: D019661:Apiaceae / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry / Q000302:isolation & purification*; D016207:Cytokines / Q000097:blood; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D013057:Spectrum Analysis
chemical_list: D001565:Benzoates; D016207:Cytokines; D008070:Lipopolysaccharides