Uses of granulocyte-macrophage colony-stimulating factor in vaccine development.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a potent cytokine capable of inducing differentiation, proliferation, and activation of a variety of immunologically active cell populations. In addition to its effects on stimulating granulocytic hematopoiesis, it also facilitates development of both humoral and cellular mediated immunity. Accordingly, strategies involving the use of GM-CSF as a vaccine adjuvant have attracted considerable attention. These strategies include the systemic administration of soluble GM-CSF with an immunogen, and also its use as part of gene therapy approaches to immunization. Because of the potency of this cytokine as an immune adjuvant, particular interest has focused on its use to overcome poorly immunogenic antigens such as those associated with intracellular infections and cancer. This review focuses on recent advances in the use of GM-CSF as a vaccine adjuvant.
Warren
T L
TL
University of Iowa Cancer Center and the Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
Weiner
G J
GJ
D000276:Adjuvants, Immunologic / Q000097:blood / Q000627:therapeutic use; D000818:Animals; D015316:Genetic Therapy; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D016233:Immunotherapy, Active / Q000379:methods / Q000592:standards; D019444:Vaccines, DNA / Q000097:blood
D000276:Adjuvants, Immunologic; D019444:Vaccines, DNA; D016178:Granulocyte-Macrophage Colony-Stimulating Factor