title: Heterogeneity of anti-PR3 associated disease in Hong Kong.
abstract: Thirty seven patients tested positive for antibody against proteinase 3 (anti-PR3) using either one of the two in-house ELISA methods at the Immunology Laboratory, University of Hong Kong. All except three were Chinese. Systemic vasculitis was diagnosed in 13 patients. However, the positive predictive value of anti-PR3 for Wegener's granulomatosus was low (22%). The commonest presenting feature was respiratory (32%). Both respiratory and renal symptoms were commonly reported in anti-PR3 positive patients as in previous studies. In this largely Chinese population, there is marked variability in the spectrum of diseases associated with anti-PR3; though many had vasculitic diseases, some were diagnosed with other conditions such as inflammatory bowel diseases and respiratory infection. In contrast with series in white people, antimyeloperoxidase rather than anti-PR3 associated disease is more prevalent in Chinese patients.
authors.affiliation: Department of Pathology, The University of Hong Kong, Queen Mary Hospital Compound, Hong Kong.
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: J W
authors.initials: JW
authors.lastname: Lawton
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D002681:China / Q000208:ethnology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis* / Q000453:epidemiology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin; D012697:Serine Endopeptidases / Q000276:immunology*; D014657:Vasculitis / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D012697:Serine Endopeptidases; D053146:Myeloblastin