title: Bronchocentric granulomatosis: computed tomographic findings in five patients.
abstract: OBJECTIVE
  The aim of this study was to assess the CT manifestations of bronchocentric granulomatosis.
  
  
  METHODS
  The CT results of five patients with bronchocentric granulomatosis were retrospectively analysed. The patients ranged from 20 to 72 years of age and included three men and two women. The diagnosis of bronchocentric granulomatosis was made at lobectomy (n = 2), open lung biopsy (n = 2), and transbronchial biopsy (n = 1). Only one of the five patients had asthma.
  
  
  RESULTS
  The main findings consisted of a spiculated mass lesion (n = 3) or lobar consolidation with associated mild volume loss (n = 2). One of the two patients with consolidation had extensive mucoid impaction. The abnormalities involved predominantly an upper lobe in four patients and a lower lobe in one patient. In the four resected specimens, the macroscopic pathological appearance was consolidation (n = 2) and mass lesion (n = 2). Microscopically, the typical histology of airway-centred necrotizing granulomata was present in all cases. Aspergillus hyphae were identified in two cases. Nocardia sp. was cultured from the biopsy specimen in one case.
  
  
  CONCLUSIONS
  The CT manifestations of bronchocentric granulomatosis consist of a focal mass or lobar consolidation with atelectasis. These reflect the presence of granuloma formation with or without associated bronchial obstruction.
authors.affiliation: Departments of Radiology, Vancouver Hospital and Health Sciences Centre, University of British Columbia, 855 W. 12(th)Ave, Vancouver, BC, V5Z 1M9, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Ward
authors.forename: L E
authors.initials: LE
authors.lastname: Heyneman
authors.forename: J D
authors.initials: JD
authors.lastname: Flint
authors.forename: A N
authors.initials: AN
authors.lastname: Leung
authors.forename: E A
authors.initials: EA
authors.lastname: Kazerooni
authors.forename: N L
authors.initials: NL
authors.lastname: Müller
mesh_terms: D000328:Adult; D000368:Aged; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications; D001982:Bronchial Diseases / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000473:pathology; D005260:Female; D015769:Granuloma, Respiratory Tract / Q000000981:diagnostic imaging* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed