title: Synthesis of oligonucleotides containing the oxidatively modified kappaB site: unique binding affinity to the NFkappaB p50 homodimer.
abstract: Synthesis of oligonucleotide 26-mers including single 5-formyl-2'-deoxyuridine (1) or 5-formyl-2'-O-methyluridine (2) in place of thymidine at the kappaB site has been accomplished. One of the 26-mers with 1 was critically discriminated by the NFkappaB p50 homodimer in binding.
authors.affiliation: Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kittaka
authors.forename: H
authors.initials: H
authors.lastname: Takayama
authors.forename: C
authors.initials: C
authors.lastname: Horii
authors.forename: T
authors.initials: T
authors.lastname: Kuze
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: K T
authors.initials: KT
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Miyasaka
authors.forename: J
authors.initials: J
authors.lastname: Inoue
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry; D019281:Dimerization; D016328:NF-kappa B / Q000737:chemistry* / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D016328:NF-kappa B; D009838:Oligodeoxyribonucleotides; D004247:DNA