title: Indocyanine green angiography in Sorsby's fundus dystrophy.
abstract: OBJECTIVE
  To report the indocyanine green angiographic findings in patients with a fundus dystrophy characterized by subretinal deposits, macular atrophic or neovascular degeneration and peripheral chorioretinal atrophy which is most likely Sorsby's fundus dystrophy.
  
  
  METHODS
  A series of 11 clinically affected patients and 4 asymptomatic carriers, belonging to one autosomal dominant pedigree were examined with stereoscopic funduscopy, fluorescein and indocyanine green angiography.
  
  
  RESULTS
  Subretinal deposits were found in 20 eyes of 10 patients. These deposits stained slightly on indocyanine green angiography, causing a reticular pattern. Two eyes had a disciform lesion and 3 geographic atrophy in the macula. A peripheral disciform lesion was found in 1 eye. Indocyanine green angiography identified peripapillary choroidal neovascularization in 2 eyes. Peripheral chorioretinal atrophy was found in 8 eyes of 4 patients, associated with peripheral plaques that could only be identified by indocyanine green angiography in 6 eyes of 3 patients.
  
  
  CONCLUSIONS
  Indocyanine green angiography in Sorsby's fundus dystrophy may indicate the presence of homogeneously staining, well-demarcated peripheral areas of hyperfluorescence associated with chorioretinal atrophy. These plaques correspond in our opinion to choroidal neovascularization which is otherwise unsuspected.
authors.affiliation: Department of Ophthalmology, University Hospital Gent, Belgium.
authors.forename: B A
authors.initials: BA
authors.lastname: Lafaut
authors.forename: E
authors.initials: E
authors.lastname: De Backer
authors.forename: T
authors.initials: T
authors.lastname: Kohno
authors.forename: J J
authors.initials: JJ
authors.lastname: De Laey
authors.forename: F M
authors.initials: FM
authors.lastname: Meire
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D005456:Fluorescent Dyes; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D012162:Retinal Degeneration / Q000175:diagnosis* / Q000235:genetics; D012166:Retinal Hemorrhage / Q000175:diagnosis* / Q000235:genetics; D014792:Visual Acuity
chemical_list: D005456:Fluorescent Dyes; D007208:Indocyanine Green