title: Management of a patient with a mechanical aortic valve and antibodies to both thrombin and factor V after repeat exposure to fibrin sealant.
abstract: We describe a patient who developed a markedly prolonged PT, PTT, and thrombin time 13 days after repeat exposure to fibrin sealant during coronary artery bypass grafting and aortic valve replacement. Evaluation revealed an inhibitor to bovine thrombin that cross-reacted with human thrombin. In addition an inhibitor to human coagulation factor V was identified. Despite coagulation abnormalities there was no evidence of bleeding. Nevertheless, effective anticoagulation was required to minimize the thrombotic complications associated with the patient's prosthetic valve. We elected to take a conservative approach and not utilize pharmacologic anticoagulation until there was diminution in the effect of the acquired inhibitors. We report on our patient's course and review the available literature addressing the management of patients demonstrating inhibitors to blood coagulation factors after repeat exposure to fibrin sealants.
authors.affiliation: Department of Medicine, University of Florida, Gainesville 32610, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Zumberg
authors.forename: J M
authors.initials: JM
authors.lastname: Waples
authors.forename: K J
authors.initials: KJ
authors.lastname: Kao
authors.forename: R
authors.initials: R
authors.lastname: Lottenberg
mesh_terms: D000368:Aged; D000818:Animals; D000918:Antibody Specificity; D015551:Autoimmunity; D002417:Cattle; D003429:Cross Reactions; D005165:Factor V / Q000276:immunology*; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects* / Q000276:immunology; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D013917:Thrombin / Q000276:immunology*
chemical_list: D015718:Fibrin Tissue Adhesive; D005165:Factor V; D013917:Thrombin