Lactone synthesis based on atom transfer carbonylation
[reaction: see text] Five- to seven-membered lactones were prepared from omega-hydroxyalkyl iodides and CO by atom transfer carbonylation without the need for transition metal catalysts. The reaction proceeds via a hybrid radical/ionic mechanism in which the intramolecular alcoholysis of an omega-hydroxyacyl iodide, arising from atom transfer carbonylation, leads to the lactone.
Kreimerman
S
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan.
Ryu
I
Minakata
S
Komatsu
M