title: Clinicopathological features of CD56+ nasal-type T/natural killer cell lymphomas with lobular panniculitis.
abstract: Nasal-type T/natural killer cell lymphoma (TNKCL) shows frequent extranodal involvement including the skin, and is associated with a poor prognosis. We have studied six patients with nasal-type TNKCL presenting with inflammatory subcutaneous nodular lesions with a subcutaneous lymphoid infiltrate. Clinical information was obtained from the medical records of the patients and at follow-up. All cases showed features of angiocentric lymphoma on histology, although there was diffuse cellular infiltration rather than an angiocentric pattern in the subcutis. All six patients were similar in immunophenotype: positive for CD56 and either cytoplasmic CD3 or CD45RO, but negative for B-cell markers and CD30. In situ hybridization using an anti-sense Epstein-Barr virus early regions probe showed a positive reaction in all cases. All patients either died with progressive disease or showed no response to combined chemotherapy. The diagnosis of nasal-type TNKCL, which has a fatal outcome, is facilitated by detection of CD56-positive tumour cells. In evaluating lobular panniculitis including apparently benign inflammatory subcutaneous nodules, nasal-type TNKCL should be considered in the differential diagnosis, especially in Asian countries.
authors.affiliation: Departments of Dermatology and Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-dong, Songpa-gu, Seoul 138-736, Korea.
authors.forename: S E
authors.initials: SE
authors.lastname: Chang
authors.forename: J
authors.initials: J
authors.lastname: Huh
authors.forename: J H
authors.initials: JH
authors.lastname: Choi
authors.forename: K J
authors.initials: KJ
authors.lastname: Sung
authors.forename: K C
authors.initials: KC
authors.lastname: Moon
authors.forename: J K
authors.initials: JK
authors.lastname: Koh
mesh_terms: D000328:Adult; D000368:Aged; D016375:Antisense Elements (Genetics); D019002:CD56 Antigen / Q000032:analysis*; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017403:In Situ Hybridization; D007694:Killer Cells, Natural / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry / Q000276:immunology*; D015434:Panniculitis / Q000276:immunology / Q000473:pathology*; D011379:Prognosis
chemical_list: D016375:Antisense Elements (Genetics); D019002:CD56 Antigen