[Non-invasive detection of endothelial dependent dilatation dysfunction in patients with essential hypertension].
With high-resolution ultrasound, we measured the diameter of the brachial arteries at rest, during reactive hyperaemia (with increase flow causing endothelium-dependent dilatation), and after sublingual glyceryl trinitrate(GTN; causing endothelium-independent dilatation) in 61 subjects, consisting of 30 controls with normal blood pressure(NP) and 31 patients with established essential hypertension(EH). The results showed that in patients with EH, flow-mediated dilatation in arteries was much reduced for comparison with control group(P < 0.01). However, there was no significant difference in response to GTN between two groups(P > 0.05). It indicates that endothelium-dependent vasodilation is impaired in patients with essential hypertension.
Li
J
J
Department of Cardiology, Second Affililated Hospital, Hunan Meddical University, Changsha.
Zhao
S
S
Li
X
X
D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000473:pathology / Q000503:physiopathology*; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000502:physiology*; D014664:Vasodilation
D009569:Nitric Oxide