title: Asymmetric synthesis of bicyclic ketones having an angular substituent via Ti(II) alkoxide-mediated tandem cyclization of trisubstituted olefinic substrates
abstract: [reaction: see text] Angularly substituted, optically active bicyclic ketones of up to 94% ee were prepared by the Ti(II) alkoxide-mediated tandem cyclization of open-chain substrates, that is, 8-phenylmenthyl enynoates having a trisubstituted double bond.
authors.affiliation: Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Kanagawa, Japan.
authors.initials: H
authors.lastname: Urabe
authors.initials: D
authors.lastname: Hideura
authors.initials: F
authors.lastname: Sato