title: Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study.
abstract: Some studies show that plasma triglyceride (TG) levels are a significant independent risk factor for cardiovascular disease (CVD). TG levels are inversely correlated with high density lipoprotein cholesterol (HDL-C) levels, and their metabolism may be closely interrelated. Therefore, the TG/HDL-C ratio may be a relevant CVD risk factor. Our analysis of families in the Framingham Heart Study gave a genetic heritability estimate for log(TG) of 0.40 and for log(TG/HDL-C) of 0.49, demonstrating an important genetic component for both. A 10 cM genome-wide scan for log(TG) level and log(TG/HDL-C) was carried out for the largest 332 extended families of the Framingham Heart Study (1702 genotyped individuals). The highest multipoint variance component LOD scores obtained for both log(TG) and log(TG/HDL-C) were on chromosome 7 (at 155 cM), where the results for the two phenotypes were 1.8 and 2.5, respectively. The 7q32.3-qter region contains several candidate genes. Four other regions with multipoint LOD scores greater than one were identified on chromosome 3 [LOD score for log(TG/HDL-C) = 1.8 at 140 cM], chromosome 11 [LOD score for log(TG/HDL-C) = 1.1 at 125 cM], chromosome 16 [LOD score for log(TG) = 1.5 at 70 cM, LOD score for log(TG/HDL-C) = 1.1 at 75 cM] and chromosome 20 [LOD score for log(TG/HDL-C) = 1.7 at 35 cM, LOD score for log(TG) = 1.3 at 40 cM]. These results identify loci worthy of further study.
authors.affiliation: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, shearman@mit.edu
authors.forename: A M
authors.initials: AM
authors.lastname: Shearman
authors.forename: J M
authors.initials: JM
authors.lastname: Ordovas
authors.forename: L A
authors.initials: LA
authors.lastname: Cupples
authors.forename: E J
authors.initials: EJ
authors.lastname: Schaefer
authors.forename: M D
authors.initials: MD
authors.lastname: Harmon
authors.forename: Y
authors.initials: Y
authors.lastname: Shao
authors.forename: J D
authors.initials: JD
authors.lastname: Keen
authors.forename: A L
authors.initials: AL
authors.lastname: DeStefano
authors.forename: O
authors.initials: O
authors.lastname: Joost
authors.forename: P W
authors.initials: PW
authors.lastname: Wilson
authors.forename: D E
authors.initials: DE
authors.lastname: Housman
authors.forename: R H
authors.initials: RH
authors.lastname: Myers
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000097:blood* / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood* / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7; D015331:Cohort Studies; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014280:Triglycerides / Q000097:blood* / Q000235:genetics*
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides