[Effect of octreotide on the hepatic metastasis of human colorectal cancer: an experimental model in athymic mice].
The aim of this randomized study was to determine the effects of octreotide therapy on the growth and development of experimental liver metastases from a human colonic cancer cell line (HT 29) in nude mice model. No important and significant difference could be found between mice, lungs and liver weights of both groups as well as lung metastatization; indeed, significant was the difference between groups concerning liver, metastases (the majority of them were in treated group): in spite of the small number of data collected, which does not allow to draw any conclusion on the efficacy of this drug on liver metastases, we believe that octreotide therapy does not affect dramatically the growth and development of liver metastases from a human colon cancer.
Giustozzi
G M
GM
Dipartimento di Scienze Chirurgiche, Policlinico, Università degli Studi, Perugia.
Lucaroni
E
E
Lauro
A
A
Goracci
G L
GL
Bartoli
A
A
Radicchi
V
V
Monacelli
M
M
Cirocchi
R
R
Bisacci
C
C
Moggi
L
L
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation / Q000379:methods; D015282:Octreotide / Q000627:therapeutic use*
D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide