title: Severe skin rash in two consecutive patients treated with 2-chlorodeoxyadenosine for hairy cell leukaemia at a single institution.
abstract: Although hairy cell leukaemia was first described 40 years ago, it is only in the last decade that newer therapeutic agents have enabled effective treatment. The purine nucleoside analogue, 2-chlorodeoxyadenosine (2-CdA) is currently considered as first-line therapy with a very high rate of complete remission. Although adverse events with 2-CdA are increasingly recognized, severe cutaneous reactions have been reported rarely. We describe two consecutive patients treated with 2-CdA for hairy cell leukaemia who both suffered extremely severe cutaneous reactions, one of which was life-threatening.
authors.affiliation: Haematology/Oncology Unit, Blackpool Victoria Hospital NHS Trust, Blackpool, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Grey
authors.forename: N G
authors.initials: NG
authors.lastname: Flanagan
authors.forename: P R
authors.initials: PR
authors.lastname: Kelsey
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D017338:Cladribine / Q000008:administration & dosage / Q000009:adverse effects*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced / Q000628:therapy; D004890:Erythema / Q000139:chemically induced* / Q000628:therapy; D004892:Erythema Multiforme / Q000139:chemically induced / Q000628:therapy; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000150:complications* / Q000188:drug therapy; D008297:Male
chemical_list: D000900:Anti-Bacterial Agents; D017338:Cladribine