title: 13C-Urea breath test is superior in sensitivity to detect Helicobacter pylori infection than either antral histology or rapid urease test.
abstract: There is no single technique which fulfils the criterion for a reference method to detect Helicobacter pylori (Hp) infection. The aim was to compare the results of antral histology (H), rapid urease test (U) and urea breath test (UBT) from antral biopsy samples in patients having gastric or duodenal lesions during upper GI endoscopy. We used the following methods: 1) biopsy specimens for histology (Warthin-Starry staining); 2) rapid urease test; and 3) 13C-urea breath test with infrared spectrometry. The total number of patients was 166 examined by H, U, and UBT. H, U and UBT were negative (-) in 64 patients and positive (+) in 51. The true positivity and false negativity (%, number of patients in parentheses) of each method based upon the positivity of the other two tests were: H+, U+ (54): UBT+, 94.4% (51) and UBT-, 5.6% (3); H+, UBT+ (57): U+, 89.5% (51) and U-, 10.5% (6); U+, UBT+ (65): H+, 78.5% (51) and H-, 21.5% (14). If Hp infection is considered to be positive when at least two tests detect the presence of Hp, UBT shows the highest sensitivity in comparison to histology of biopsy specimens and urease test. UBT is highly recommended as a screening test for Hp infection in patients presenting upper GI endoscopic alterations.
authors.affiliation: First Department of Medicine, University Medical School Pécs, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Sütö
authors.forename: A
authors.initials: A
authors.lastname: Vincze
authors.forename: F
authors.initials: F
authors.lastname: Pakodi
authors.forename: B
authors.initials: B
authors.lastname: Hunyady
authors.forename: O
authors.initials: O
authors.lastname: Karádi
authors.forename: M
authors.initials: M
authors.lastname: Garamszegi
authors.forename: T
authors.initials: T
authors.lastname: László
authors.forename: G
authors.initials: G
authors.lastname: Mózsik
mesh_terms: D001944:Breath Tests / Q000379:methods; D016099:Endoscopy, Gastrointestinal; D005188:False Negative Reactions; D005189:False Positive Reactions; D016481:Helicobacter Infections / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D011706:Pyloric Antrum / Q000473:pathology*; D015203:Reproducibility of Results; D014508:Urea / Q000032:analysis*; D014510:Urease / Q000032:analysis*
chemical_list: D014508:Urea; D014510:Urease