title: Huerthle cell neoplasms of the thyroid: predicting malignant potential.
abstract: OBJECTIVE
  Assessment of malignancy criteria in Huerthle cell neoplasm.
  
  
  METHODS
  This study intends to review retrospectively the patients who were operated for Huerthle cell neoplasia at Gazi University, Department of General Surgery between January 1986 and October 1999. Pathological specimens from 63 patients (20 males and 43 females) were investigated in this study, 48 of which revealed Huerthle cell adenoma and 15 revealed Huerthle cell carcinoma. The mean age of the patients with Huerthle cell adenoma was 40.7+/-1.59 yr while it was 51.3+/-1.83 yr in patients with Huerthle cell carcinoma. Mann-Whitney U and Chi-square tests were used for statistical analysis.
  
  
  RESULTS
  . Fifty-two of the 63 patients had fine needle aspiration (FNA) biopsy prior to operation, 49 of those were reported to have suspected Huerthle cell neoplasia (HCN) and three had suspected Huerthle cell carcinoma (HCC). The sensitivity of FNA for HCN was 20 %, specificity was 100 %, positive predictive value was 100 % and negative predictive value was 76 %. For all patients, peroperative frozen section (FS) biopsy was examined. Fifty-nine of the FS specimens revealed HCN and four revealed HCC. The sensitivity, specificity, positive predictive value and negative predictive value of FS biopsy were 27 %, 79 %, 28.5 % and 77.5 %, respectively. In this retrospective study, there was a statistically significant correlation between malignancy and the size of the tumor (P<0.05) according to Chi-square test, and also a statistically significant correlation between malignancy and the age of the patient (P<0.05) according to Mann-Whitney U test.
  
  
  CONCLUSIONS
  In cases where FS and FNA biopsies cannot adequately define the benign or malignant behaviour of the tumor, the age of the patient and the diameter of the tumor must be taken into consideration for accurate surgical strategy. Particularly for 50 year-old and elderly, incidence of malignancy is statistically significant without considering sex of the patient.
authors.affiliation: Gazi University, Faculty of Medicine, Beoevler, Ankara, Turkey. zanadol@yahoo.com
authors.forename: F
authors.initials: F
authors.lastname: Taneri
authors.forename: E
authors.initials: E
authors.lastname: Tekin
authors.forename: B
authors.initials: B
authors.lastname: Salman
authors.forename: A Z
authors.initials: AZ
authors.lastname: Anadol
authors.forename: E
authors.initials: E
authors.lastname: Ersoy
authors.forename: A
authors.initials: A
authors.lastname: Poyraz
authors.forename: E
authors.initials: E
authors.lastname: Onuk
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018249:Adenoma, Oxyphilic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000328:Adult; D001706:Biopsy; D001707:Biopsy, Needle; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy