The effect of varying substituents on the equilibrium distribution and conformation of macrocyclic steroidal N-acyl hydrazones
The equilibrium distribution of deoxycholate-based macrocyclic N-acyl hydrazones is dependent upon the nature of the substituents at the 3- and 12-position. These substituents can also influence the preferred conformation of the macrocycles. The conversion of pure cyclic dimer and trimer into a mixture of both components, in the presence of trifluoroacetic acid, has been demonstrated and an X-ray crystal structure obtained of a macrocyclic N-acyl hydrazone dimer.
Simpson
MG
University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, U.K.
Watson
SP
Feeder
N
Davies
JE
Sanders
JK