Use of gamma-carboxy-alpha,beta-unsaturated aldehydes as synthetic equivalents of beta,gamma-unsaturated aldehydes in a novel stereoselective approach to diketides
[reactions: see text] A two-step aldol/Pd-catalyzed formate reduction sequence allows for convenient, stereoselective access to products of great potential in synthetic approaches to polyketides. A novel diastereoselective Pd-catalyzed formate reduction of allylic acetates is reported.
Hughes
G
Department of Chemistry, University of Toronto, Ontario, Canada.
Lautens
M
Wen
C