Analysis of salbutamol and related impurities by derivative spectrometry.
Ultraviolet derivative spectrometry has been proposed for the analysis of salbutamol and related impurities. The assay of salbutamol aldehyde, 5-formyl-saligenin, and salbutamol ketone was performed in sodium hydroxide 0.1 mol/l solutions, using first and second derivative spectra. The method has been applied for the assay of related impurities of commercial samples of salbutamol sulfate.
Aboul-Enein
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Biological & Medical Research Department (MBC-03), King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Surmeian
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D000318:Adrenergic beta-Agonists / Q000032:analysis / Q000737:chemistry / Q000592:standards; D000420:Albuterol / Q000031:analogs & derivatives / Q000737:chemistry* / Q000592:standards; D001993:Bronchodilator Agents / Q000032:analysis / Q000737:chemistry / Q000592:standards; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003257:Consumer Product Safety; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013607:Tablets / Q000032:analysis / Q000737:chemistry / Q000592:standards
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D013607:Tablets; D000420:Albuterol