[Pathogenetic basis for the use of GABA-ergic preparations in combination with atropine during chronic pain syndrome in patients with neurologic manifestations of lumbar osteochondrosis].
The intensity of neuronal uptake of 3H- or 14C-labeled GABA, glycine, noradrenaline, choline and glucocorticoid receptor binding were investigated in different structures of the rabbit CNS by simulating chronic pain syndrome. Data obtained allow to suggest pathogenetically justified therapy including the complexes of phenybute + atropine and relanium + atropine. The contents of Leu-Enkephaline, cortisol, insuline and insuline/cortizole ratio were studied in the blood serum of the patients with neurological manifestations of lumbar osteochondrosis and a long case history of the pain treated by the above mentioned complexes. The proposed therapeutical approach allowed to achieve pronounced antistress effect and regression of the pain syndrome due to stimulation of the CNS endogenic antinociceptive structures. It was shown that stress-produced hormones and opioids ratio in the blood serum may serveas indirect criteria of the functional activity of the endogenic antinociceptive structures before and after the treatment.
Nechipurenko
N I
NI
Research Inst. of Neurology, Neurosurgery and Physiotherapy, Minsk, Belarus.
Dudina
T V
TV
Elkina
A I
AI
Elkin
Iu B
IuB
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001285:Atropine / Q000008:administration & dosage*; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004743:Enkephalin, Leucine / Q000097:blood; D005260:Female; D018682:GABA Agents / Q000008:administration & dosage*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D017116:Low Back Pain / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D010007:Osteochondritis / Q000097:blood / Q000150:complications*; D011817:Rabbits
D000700:Analgesics; D018682:GABA Agents; D007328:Insulin; D004743:Enkephalin, Leucine; D001285:Atropine; D006854:Hydrocortisone