Three families with polyneuropathy associated with monoclonal gammopathy.
OBJECTIVE
To report familial occurrence of polyneuropathy associated with monoclonal gammopathy.


METHODS
Case reports.


METHODS
We describe 6 patients (3 pairs) with a polyneuropathy associated with IgM monoclonal gammopathy. Four of the 6 patients had a demyelinating polyneuropathy on neurophysiological examination. Three patients had elevated antibodies against myelin-associated glycoprotein. No duplication on chromosome 17 or a mutation on chromosome 1 was found in any family.


CONCLUSIONS
Familial occurrence of polyneuropathy without the presence of hereditary motor and sensory neuropathy type I is a reason to search for the presence of monoclonal gammopathy.
Manschot
S M
SM
Department of Neuromuscular Disorders, Rudolf Magnus Institute of Neurosciences, Utrecht, The Netherlands.
Notermans
N C
NC
van den Berg
L H
LH
Verschuuren
J J
JJ
Lokhorst
H M
HM
D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications* / Q000235:genetics / Q000276:immunology; D011115:Polyneuropathies / Q000209:etiology* / Q000235:genetics
D007074:Immunoglobulin G; D018992:Myelin-Associated Glycoprotein