Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented 'Dang-Gui decoction for enriching blood', a compound formulation, ex vivo.
'Dang-Gui Decoction for Enriching the Blood' (BE), a traditional Chinese formulation comprising Angelica sinensis and Astragalus membranaceus, is used for stimulating red blood cell production as well as enhancing cardiovascular function. In the present study, we have demonstrated the myocardial protection afforded by BE pretreatment against ischaemia-reperfusion (IR) injury in isolated-perfused rat hearts. A more complete and potent myocardial protection against IR injury was also shown by a Polygonum multiflorum extract supplemented BE preparation (BEA). The results suggest that the more potent cardioprotective action of BEA may be related to its ability to sustain the myocardial glutathione antioxidant status under conditions of IR-induced oxidative stress, which may possibly in turn result from the synergistic interaction between the BE and Polygonum extract.
Yim
T K
TK
Department of Biochemistry, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.
Wu
W K
WK
Pak
W F
WF
Mak
D H
DH
Liang
S M
SM
Ko
K M
KM
D029971:Angelica sinensis; D000818:Animals; D027885:Astragalus propinquus; D002681:China; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C044613:angelicae sinensis extract; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione