[Cyclosporin in an oral microemulsion as the initial treatment of corticoid-refractory ulcerative colitis].
OBJECTIVE
To assess the efficacy of oral microemulsion cyclosporin as the initial treatment of active ulcerative colitis refractory to steroid therapy.


METHODS
The evolution of five patients treated with a dose of 5 mg/kg/day was analyzed.


RESULTS
Oral microemulsion cyclosporin controlled acute attacks of the disease and led to remission during the 3 months of treatment in four of the five patients. Average hospital stay was 5.5 days.


CONCLUSIONS
Oral microemulsion cyclosporin is an effective treatment in ulcerative colitis. Its administration is simple, the use of venous catheters is avoided and it may reduce mean hospital stay.
Ortiz
V
V
Servicio de Medicina Digestiva, Hospital La Fe, Valencia. vicortiz@comv.es
Nos
P
P
Aguilera
V
V
Berenguer
J
J
Ponce
J
J
D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000037:antagonists & inhibitors*; D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000097:blood / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D004351:Drug Resistance; D004655:Emulsions; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D008297:Male
D000305:Adrenal Cortex Hormones; D004655:Emulsions; D007166:Immunosuppressive Agents; D016572:Cyclosporine