Development of an automated synthesis apparatus for L-[3-11C] labeled aromatic amino acids.
We have developed an automated synthesis apparatus for L-[3-11C]-labeled aromatic amino acids by improved multi-enzymatic reactions. Use of a specially designed reaction vessel and of CH2Cl2 as a solvent has greatly simplified the overall operation, proving to be suitable for automated synthesis, and also has given better yields and higher specific activities than formerly reported values.
Harada
N
N
Central Research Lahoratory, Hamamatsu Photonics K.K., Hamakita, Shizuoka, Japan.
Nishiyama
S
S
Sato
K
K
Tsukada
H
H
D006916:5-Hydroxytryptophan / Q000138:chemical synthesis; D000409:Alanine / Q000138:chemical synthesis; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis*; D001331:Automation; D002250:Carbon Radioisotopes; D004295:Dihydroxyphenylalanine / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods*
D000598:Amino Acids, Cyclic; D002250:Carbon Radioisotopes; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D000409:Alanine