A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements.
To clarify the behavior of the novel platelet-activating factor (PAF) receptor antagonist E5880 in aqueous solution, electric conductivity was measured at different temperatures (every 5 degrees C), ranging from 15 degrees C to 50 degrees C. Critical micellization concentration (CMC) of E5880 was dependent on the temperature; at 30 degrees C, the CMC value was smallest (0.143 mM). Below that temperature, the enthalpy for formation of the micelle (delta Hm0) was positive, and the formation of micelles was endothermic; above that temperature, delta Hm0 was negative, and the formation of micelles was exothermic.
Asai
Y
Y
Formulation Research Laboratory, Kawashima, Eisai Company, Gifu, Japan.
Nomura
T
T
Murahashi
N
N
Iwamoto
K
K
D004333:Drug Administration Routes; D004560:Electricity; D008823:Micelles; D055585:Physical Phenomena; D010825:Physics; D010880:Piperidines / Q000032:analysis*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors* / Q000737:chemistry; D011726:Pyridinium Compounds / Q000032:analysis*; D013696:Temperature; D014867:Water
D008823:Micelles; D010880:Piperidines; D010972:Platelet Activating Factor; D011726:Pyridinium Compounds; D014867:Water; C072429:E 5880