Synthesis and antibacterial activity of some new non-proteinogenic amino acids containing thiazole residues.
Some new thioamides and thiazoles have been synthesized using canavanine, S-cysteine, homo-S-cysteinesulfonamides and their N-omega aminoethylated derivatives as adducts in order to investigate the structure-antimicrobial activity relationships. The compounds showed substantial antibacterial activity in vitro against various gram-positive (Staphylococcus aureus, Bacillus cereus etc.) and gram-negative (Escherichia coli, Proteus vulgaris etc.) bacteria. These findings indicate that the presence of the thiazole residue is an essential factor for the antibacterial effect.
Stanchev
M
M
Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia.
Pajpanova
T
T
Golovinsky
E
E
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D002176:Candida albicans / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D008956:Models, Chemical; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D013449:Sulfonamides / Q000737:chemistry; D013696:Temperature; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology; D013854:Thioamides / Q000737:chemistry
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013449:Sulfonamides; D013844:Thiazoles; D013854:Thioamides