[Clinical study on reduction of postpartum bleeding in cesarean section by misoprostol].
OBJECTIVE
To observe the effects of misoprostol on reduction of postpartum bleeding in cesarcan section.


METHODS
One hundred and eighty-two cesarean sections were randomized into three groups: misoprostol group (n = 60), 600 micrograms misoprostol was given orally when peritoneum was incised; misoprostol and oxytocin group (n = 64), 600 micrograms misoprostol was given orally and 20 IU oxytocin was injected into uterine muscle immediately after delivery of baby. Oxytocin group (n = 58), 20 IU oxytocin was injected into uterine muscle and 20 IU intravenous injection immediately after delivery of baby. The amount of bleeding within 2 hours after delivery was measured.


RESULTS
The mean amount of bleeding in misoprostol group was 212 +/- 56.0 ml, in misoprostol and oxytocin group was 208 +/- 55.4 ml, oxytocin group was 345 +/- 64.7 ml, respectively. The difference was significant P < 0.01 between misoprostol group and oxytocin group, there was no differences between misoprostol group and misoprostol plus oxytocin group.


CONCLUSIONS
Misoprostol is more effective in reduction of postpartum bleeding than that of oxytocin.
Zhao
Y
Y
Fifth Hospital of Jinan.
Li
X
X
Peng
Y
Y
D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D002585:Cesarean Section; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000517:prevention & control; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011247:Pregnancy
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol