Renal function in the diabetic pregnant rats.
Diabetic nephropathy is associated with increased urinary albumin and reduce kallikrein excretion. Increased activity of the renal kallikrein-kinin system has been suggested as one of the possible mechanisms underlying diabetic hyperfiltration. The present study shown that the Kallikrein-kinin system is progressively increased in the diabetic-pregnant rats at 7, 14, 21 days; 48 and 7 days after pregnancy (P < 0.05 vs Control). However, this increase during diabetic pregnancy did not reached the levels of control pregnancy. On the other hand albumin excretion shown a significant and progressive renal damage in the diabetic state. These findings suggest that the diabetic pregnancy could impair the renal hemodynamic, but, on the other side could modulate the vasodilator system at pregnancy in the attempt to protect the fetus.
Marina-Prendes
M G
MG
Facultad de Farmacia y Bioquímica, Cátedra de Fisiología, Universidad de Buenos Aires.
Zuccollo
A
A
Catanzaro
O L
OL
D000818:Animals; D015415:Biomarkers / Q000652:urine; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000652:urine*; D003928:Diabetic Nephropathies / Q000503:physiopathology / Q000652:urine*; D005260:Female; D007610:Kallikreins / Q000652:urine*; D008297:Male; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology / Q000652:urine*; D051381:Rats; D017208:Rats, Wistar
D015415:Biomarkers; D007610:Kallikreins