Hepatic fibrogenesis and hepatitis C.
Hepatitis C virus (HCV) infection is currently the most common cause of fibrosing liver disease and represents a major clinical challenge. In patients with HCV infection, inflammation and injury lead to fibrosis and cirrhosis in a significant proportion of patients; cirrhosis in turn has multiple clinical sequelae. Therefore, understanding the pathological basis of fibrogenesis in hepatitis C infection is critical. This review will highlight fundamental issues underlying the fibrogenic response to injury and in addition will focus on potential points of intervention.
Rockey
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Liver Center and Department of Medicine and Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000818:Animals; D001706:Biopsy; D002478:Cells, Cultured; D003078:Colchicine / Q000008:administration & dosage; D018450:Disease Progression; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012176:Retinoids / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D012176:Retinoids; D007372:Interferons; D003078:Colchicine