Enhanced tumor necrosis factor in the serum and renal hypoperfusion in nephrosis associated with focal segmental glomerulosclerosis.
Enhanced tumor necrosis factor alpha associated with immunocirculatory imbalance expressed as increased ratio between proinflammatory (TNFalpha) and antiinflammatory (IL-10) cytokines was observed in the serum of nephrosis associated with focal segmental glomerulosclerosis. Such altered immunocirculatory balance correlated with the reduction in renal plasma flow determined by the intrarenal hemodynamic study by which it implies that a glomerular endothelial cell injury associated with impaired renal perfusion is likely to be spontaneously induced by enhanced tumor necrosis factor in the presence of inadequate release of antiinflammatory cytokine (IL-10).
Futrakul
N
N
Department of Physiology and Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Butthep
P
P
Patumraj
S
S
Tipprukmas
N
N
Futrakul
P
P
D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005919:Glomerular Filtration Rate; D015432:Glomerulonephritis, Membranoproliferative / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D007511:Ischemia / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000098:blood supply* / Q000503:physiopathology; D009401:Nephrosis / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D012079:Renal Circulation; D017595:Renal Plasma Flow; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10