title: Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity.
authors.affiliation: Novartis Pharma AG, TA Oncology Research, WKL-136.4.21, CH-4002, Basel, Switzerland. karl-heinz.altmann@pharma.novartis.com
authors.forename: K H
authors.initials: KH
authors.lastname: Altmann
authors.forename: M
authors.initials: M
authors.lastname: Wartmann
authors.forename: T
authors.initials: T
authors.lastname: O'Reilly
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D018432:Drug Resistance, Multiple; D004361:Drug Tolerance; D034261:Epothilones; D004852:Epoxy Compounds / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D007783:Lactones / Q000737:chemistry; D008870:Microtubules / Q000187:drug effects*; D015394:Molecular Structure; D017239:Paclitaxel / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; D004852:Epoxy Compounds; D007783:Lactones; D013844:Thiazoles; D014404:Tubulin; C110841:desoxyepothilone A; C093787:epothilone A; D017239:Paclitaxel; C114026:desoxyepothilone B; C093788:epothilone B