title: Reversed diastolic umbilical artery flow in the first trimester associated with chromosomal fetal abnormalities or cardiac defects.
abstract: BACKGROUND
  Six cases have been reported of reversed end-diastolic umbilical artery (UA) blood flow at 10-14 weeks' gestation. Four were associated with chromosomal anomalies, and one showed congenital heart disease.
  
  
  METHODS
  This report describes two cases of reversed end-diastolic UA flow at 10 and 12 weeks' gestation with increased nuchal translucency in which cytogenetic analysis by chorionic villus sampling showed triploidy (69,XXX) and trisomy 9, respectively. In second case, the fetus had a ventricular septal defect.
  
  
  CONCLUSIONS
  Reversed end-diastolic UA flow in the first trimester might be an important sign of chromosomal abnormalities in early pregnancy and might be a useful signal for the diagnosis of early cardiac defects.
authors.affiliation: Department of Obstetrics and Gynecology, Federal University of São Paulo, São Paulo, Brazil. cgvmurta@zaz.com.br
authors.forename: C G
authors.initials: CG
authors.lastname: Murta
authors.forename: A F
authors.initials: AF
authors.lastname: Moron
authors.forename: M A
authors.initials: MA
authors.lastname: Avila
mesh_terms: D000328:Adult; D015193:Chorionic Villi Sampling; D002869:Chromosome Aberrations; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis; D006345:Heart Septal Defects, Ventricular / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012039:Regional Blood Flow; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000502:physiology*