title: Nitric oxide involvement in the trigeminal hyperalgesia in diabetic rats.
abstract: Trigeminal hyperalgesia frequently appears in diabetic neuralgia altering the transmission of orofacial sensory information. This study was designed to explore the effects of trigeminal hyperalgesia in streptozotocin-induced diabetes monitoring the expression of nitric oxide synthase in the trigeminal ganglion cells. The threshold to heat noxious stimuli decreased in diabetic animals. The number of NADPH-diaphorase (NADPH-d)-positive neurons significantly decreased in the diabetic rats compared with controls. Insulin treatment prevented the decreased nociceptive threshold and reduction of the number of NADPH-d-positive neurons. These findings point out that there is a relationship between the trigeminal nociceptive perception and NADPH-d neuronal expression suggesting that NO may play a role in the pathogenesis of trigeminal sensory neuropathy.
authors.affiliation: Department of Biomedical Sciences and Biotechnology, Division of Human Anatomy, University of Brescia, Via Valsabbina 19, 25124, Brescia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Rodella
authors.forename: R
authors.initials: R
authors.lastname: Rezzani
authors.forename: G
authors.initials: G
authors.lastname: Corsetti
authors.forename: R
authors.initials: R
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D002452:Cell Count; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D006930:Hyperalgesia / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D009249:NADP / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009619:Nociceptors / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D010147:Pain Measurement; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D012668:Trigeminal Ganglion / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014276:Trigeminal Nerve / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D020433:Trigeminal Nerve Diseases / Q000503:physiopathology*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D009569:Nitric Oxide; D009249:NADP; D019001:Nitric Oxide Synthase