title: Creatine monohydrate in muscular dystrophies: A double-blind, placebo-controlled clinical study.
abstract: The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind, crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Council scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.
authors.affiliation: Friedrich-Baur-Institute, Ludwig-Maximilians-University of Munich, Germany. Maggie.Walter@lrz.uni-muenchen.de
authors.forename: M C
authors.initials: MC
authors.lastname: Walter
authors.forename: H
authors.initials: H
authors.lastname: Lochmüller
authors.forename: P
authors.initials: P
authors.lastname: Reilich
authors.forename: T
authors.initials: T
authors.lastname: Klopstock
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: M
authors.initials: M
authors.lastname: Hartard
authors.forename: M
authors.initials: M
authors.lastname: Hennig
authors.forename: D
authors.initials: D
authors.lastname: Pongratz
authors.forename: W
authors.initials: W
authors.lastname: Müller-Felber
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000188:drug therapy* / Q000235:genetics; D009460:Neurologic Examination / Q000187:drug effects; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D003401:Creatine