title: Nutritional (n-3) polyunsaturated fatty acids influence the behavioral responses to positive events in mice.
abstract: The effect of (n-3) polyunsaturated fatty acid (PUFA) diet deficiency on behavioural responses to appetitive events was assessed in OF1 mice. Pups fed the same diet (deficient in alpha-linolenic acid or a standard control diet) as their dams were used aged 7 to 11 weeks. In a free choice model, the preference for a sucrose solution in both males and females was significantly lower in deficient than in control mice. Morphine conditioned place preference was obtained with the two diets at 8 and 16 mg/kg morphine, but the lower dose of 4 mg/kg induced a place preference in control but not in (n-3) deficient mice. Taken together, these results suggest that a nutritional (n-3) PUFA deficiency can alter the responsiveness to appetitive events.
authors.affiliation: INSERM U26, Hôpital Fernand Widal, 200 rue du Faubourg St. Denis, 75475, Paris, France. henriette.frances@inserm.lrb.ap-hop-paris-fr
authors.forename: H
authors.initials: H
authors.lastname: Francès
authors.forename: P
authors.initials: P
authors.lastname: Draï
authors.forename: M
authors.initials: M
authors.lastname: Smirnova
authors.forename: I
authors.initials: I
authors.lastname: Carrié
authors.forename: M
authors.initials: M
authors.lastname: Debray
authors.forename: J M
authors.initials: JM
authors.lastname: Bourre
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D015525:Fatty Acids, Omega-3; D009294:Narcotics; D013395:Sucrose; D009020:Morphine