title: [Epidemiological, clinical and therapeutic aspects of severe malaria in adults in the infectious disease department of Central University Hospital of Dakar].
abstract: To assess epidemiological, clinical and therapeutic features of severe malaria among adults in Dakar (Senegal), we carried out a 5-year retrospective study in Infectious Diseases Ward (January 1992-December 1996). Over this period, 222 cases of severe malaria were included according to WHO definition criteria, 120 of them (54%) being adult patients. Monthly distribution of cases showed 2 peaks, on October and November. Most of the patients were males (sex-ratio = 2.1) and lived in urban area (91.7%). The mean age was 28.9 years (range = 16-73 years). Clinically, all of the cases presented with stage II coma. Association existed with convulsion (20%), severe anaemia (29.2%), renal failure (19.2%), hypoglycaemia (17.5%) and jaundice (34%). Patients were treated using quinine intravenously. Case fatality rate reached 26.7%, indicating life-threatening potential of malaria in adults living in urban area.
authors.affiliation: Clinique des Maladies Infectieuses CHU de Fann, Dakar.
authors.forename: M
authors.initials: M
authors.lastname: Soumare
authors.forename: B M
authors.initials: BM
authors.lastname: Diop
authors.forename: C T
authors.initials: CT
authors.lastname: Ndour
authors.forename: Y
authors.initials: Y
authors.lastname: Dieng
authors.forename: F S
authors.initials: FS
authors.lastname: Ndiaye
authors.forename: S
authors.initials: S
authors.lastname: Badiane
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011803:Quinine / Q000627:therapeutic use; D012675:Senegal; D014505:Urban Population
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D011803:Quinine