title: 89Strontium in the management of painful sceletal metastases.
abstract: OBJECTIVE
  To make a review of the literature of 89strontium-chloride and a retrospective study of time to palliative intended external irradiation, number of portals and overall-survival after 89strontium-chloride therapy.
  
  
  RESULTS
  In total 93 patients were treated 116 times with 89strontium. The patients with prostatic carcinoma received 91% of all 89strontium therapies. Median over-all survival was 10 months after injection. In those cases when 89strontium was given before palliative radiotherapy, the average of total number of local fields was significantly lower (1.1 versus 4.1) compared to those cases where local fields preceded 89strontium therapy. However, time to 89new external irradiation after 89strontium injection was equal between these groups (3.8 versus 2.9 months).
  
  
  CONCLUSIONS
  A review of literature conclude that 89strontium is effective for the reduction of pain originating from osteoblastic metastases. It also reduce the need for external radiotherapy and therefore is cost-effective. However, 89strontium is more effective in an early phase of the metastatic disease and preferably as an adjuvance to external radiotherapy.
authors.affiliation: Department of Oncology, University of Uppsala, Sweden. Karl_Mikael.Kalkner@onkologi.uu.se
authors.forename: K M
authors.initials: KM
authors.lastname: Kälkner
authors.forename: J E
authors.initials: JE
authors.lastname: Westlin
authors.forename: P
authors.initials: P
authors.lastname: Strang
mesh_terms: D001859:Bone Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000532:radiotherapy* / Q000556:secondary*; D005260:Female; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000473:pathology; D010146:Pain; D010166:Palliative Care; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D012189:Retrospective Studies; D013326:Strontium Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D016019:Survival Analysis
chemical_list: D013326:Strontium Radioisotopes