A review of oral vaccination with transgenic vegetables.
Mucosal immunization of the gastrointestinal tract is an effective way to stimulate local and systemic immune responses. Oral vaccines must be formulated in such a way that antigens are protected as they pass through the adverse environment of the stomach and are delivered to the mucosal inductive sites. Vaccine antigens cloned into edible transgenic plants are a promising new delivery system for oral vaccines. Such vaccines could be safe, inexpensive, and multicomponent.
Tacket
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Center for Vaccine Development, University of Maryland School of Medicine, Baltimore 21201, USA.
Mason
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D000276:Adjuvants, Immunologic; D000284:Administration, Oral; D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology; D004768:Enterotoxins / Q000235:genetics / Q000276:immunology; D004926:Escherichia coli / Q000235:genetics / Q000276:immunology; D029968:Escherichia coli Proteins; D006801:Humans; D018928:Immunity, Mucosal; D051379:Mice; D030821:Plants, Genetically Modified / Q000235:genetics / Q000276:immunology*; D011198:Solanum tuberosum / Q000235:genetics / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D019444:Vaccines, DNA; C027538:heat-labile enterotoxin, E coli