title: Invasive aspergillosis in a patient with MELAS syndrome.
abstract: Invasive infection with the opportunistic fungus Aspergillus fumigatus predominantly affects people with impaired cell mediated immunity. The case of a 31 year old woman with no identified cause for immunosuppression who presented with severe refractory aspergillosis of the paranasal sinuses is reported. She subsequently developed clinical and molecular evidence of mitochondrial encephalomyopathy with lactic acidosis and stroke-like events (MELAS) syndrome. It is proposed that MELAS syndrome may represent an unusual risk factor for the development of invasive aspergillosis and mechanisms are supported by which mitochondrial dysfunction may predispose to this.
authors.affiliation: Department of Neurology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK. DMcKee@Central.CMHT.NWest.NHS.uk
authors.forename: D H
authors.initials: DH
authors.lastname: McKee
authors.forename: P N
authors.initials: PN
authors.lastname: Cooper
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000175:diagnosis* / Q000503:physiopathology; D001232:Aspergillus fumigatus; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017241:MELAS Syndrome / Q000175:diagnosis* / Q000503:physiopathology; D008931:Mitochondria, Muscle / Q000502:physiology; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000503:physiopathology; D012008:Recurrence; D012307:Risk Factors; D012852:Sinusitis / Q000175:diagnosis* / Q000503:physiopathology