title: Radical cyclization of sugar-derived beta-(alkynyloxy)acrylates: synthesis of novel fused ethers
abstract: [formula: see text] Tributyltin radical mediated cyclization of carbohydrate-derived beta-(alkynyloxy)acrylates leading to highly functionalized cis- and trans-fused bicyclic ethers of various ring sizes is described. The efficacy of the radical cyclization is nicely illustrated in the iterative construction of a trans-fused tricyclic tetrahydropyran.
authors.affiliation: Leiden Institute of Chemistry, The Netherlands.
authors.initials: MA
authors.lastname: Leeuwenburgh
authors.initials: RE
authors.lastname: Litjens
authors.initials: JD
authors.lastname: Codee
authors.initials: HS
authors.lastname: Overkleeft
authors.lastname: van der Marel GA
authors.lastname: van Boom JH