Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii.
In our continuous investigation for free radical scavengers from extracts of fruit body of basidiomycetes, we have isolated four new p-terphenyl compounds, designated as curtisians A-D, from the methanolic extract of the fruit body of Paxillus curtisii. These compounds were isolated by silica gel and Sephadex LH-20 column chromatographies, preparative-TLC and HPLC, consecutively. The structures of curtisians were assigned as p-terphenyls with substituents of acetyl, benzoyl, phenylbutyryl, 3-hydroxybutyryl and 3-acetoxybutyryl. Curtisians A, B, C and D exhibited inhibitory activity against lipid peroxidation with IC50, values of 0.15, 0.17, 0.24 and 0.14 microg/ml, respectively.
Yun
B S
BS
Korea Research Institute of Bioscience and Biotechnology, Taejon.
Lee
I K
IK
Kim
J P
JP
Yoo
I D
ID
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D015764:Bepridil / Q000031:analogs & derivatives / Q000378:metabolism; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010851:Picrates; D051381:Rats
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005609:Free Radicals; D010648:Phenylacetates; D010851:Picrates; C408299:curtisian A; C408300:curtisian B; C408301:curtisian C; C408302:curtisian D; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl