[Detection methods for drug-resistant bacteria in routine examination--BLNAR].
The characteristics of resistance, trend of prevalence and current status of beta-lactamase-negative, ampicillin-intermediate or -resistant(BLNAR) strains of Haemophilus influenzae are summarized by our retrospectively analyzed data. The mechanism of this type of ampicillin-resistance is due to altered penicillin-binding proteins(PBPs). Standardized susceptibility tests may differentiate ampicillin-resistant, beta-lactamase-producing strains from beta-lactamase-negative, ampicillin-susceptible strains(BLNAS), but may not differentiate some strains of BLNAR from those of BLNAS. In the cases of serious infections, such as meningitis due to H. influenzae both beta-lactamase activity and ampicillin susceptibility should be confirmed by the MIC procedure.
Misawa
S
S
Clinical Laboratory, Juntendo University Hospital.
Nakamura
A
A
Oguri
T
T
Igari
J
J
D000668:Ampicillin Resistance; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D001618:beta-Lactamases / Q000032:analysis
D001618:beta-Lactamases