[The selenium haemostasis during experimental anaphylaxis reaction in rats treated with reduced glutathione and selenium enriched spirulina].
The main events caused by anaphilaxis in selenium haemostasis in rats include significant increase of selenium excretion with urine (6.36 +/- 1.18 nM Se/18 h., n = 10, compared with 1.72 +/- 0.38 nM Se/18 h., n = 10) and decrease of selenium plasma/selenium erythrocytes ratio from 0.939 to 0.791. Reduced glutathione (G-SH) administration led to 1.5-fold decrease of plasma selenium level and 1.3-fold increase of selenium concentration in intestinal walls of sensitized rats (r = -0.720, P < 0.001). Chromatographic separation of plasma proteins showed that intragastric intubation of G-SH to sensibilized rats significantly decreased the protein P content and did not influence the concentration of Se-GSHPx, thus indicating the local selenium acceptor role of G-SH. G-SH administration did not influence the intestinal permeability in sensitised rats while use of complex additive: G-SH and selenium enriched spirulina--normalized the latter parameter and the ratio of protein P/Se-GSHPx in plasma.
Golubkina
N A
NA
Institute of Nutrition, RAMS, Moscow.
Mazo
V K
VK
Gmoshinskiĭ
I V
IV
Zorin
S N
SN
Tambiev
A Kh
AKh
Kirikova
N N
NN
D000707:Anaphylaxis / Q000378:metabolism* / Q000503:physiopathology*; D000818:Animals; D001426:Bacterial Proteins / Q000494:pharmacology*; D004032:Diet; D005260:Female; D005978:Glutathione / Q000494:pharmacology*; D006706:Homeostasis; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism*; D053545:Spirulina
D001426:Bacterial Proteins; D005978:Glutathione; D012643:Selenium