title: What does Anisakis simplex parasitism in gastro-allergic anisakiasis teach us about interpreting specific and total IgE values?
abstract: BACKGROUND
  gastro-allergic Anisakiasis is a mostly transitory clinical entity caused by Anisakis simplex (A. simplex) and can be suspected by history and confirmed by fiberoptic gastroscopy and specific IgE.
  
  
  OBJECTIVE
  we report a case of gastro-allergic Anisakiasis, in which the parasite induces a high specific and total IgE response, and want to follow the specific and total IgE values by a serologic follow up over 10 months.
  
  
  METHODS
  an analysis of total IgE and specific IgE against. A. simplex was performed within 24 hours, after 1, 4, 6 and 10 months. At month 4 and month 10 specific IgE against Ascaris lumbricoides and Echinococcus granulosus was determined in order to value cross-reactivity.
  
  
  RESULTS
  there is an important raise in specific IgE against Anisakis simplex (up to 903 kU/l) after 6 months and total IgE (up to 15,258 kU/l) after one month. Cross-reactive specific IgE against Ascaris lumbricoides and Echinococcus granulosus can be detected.
  
  
  CONCLUSIONS
  we consider a raise of total and specific IgE as a typical feature of helminth infestation and learn that specific and total IgE values are highly variable in the months following the allergic and parasite-specific reaction. The amount of specific IgE against other cross reactive parasites depends directly on the total IgE values.
authors.affiliation: Sección de Alergia, Hospital General Universitario La Paz, Madrid, España.
authors.forename: A
authors.initials: A
authors.lastname: Daschner
authors.forename: A
authors.initials: A
authors.lastname: Alonso-Gómez
authors.forename: C
authors.initials: C
authors.lastname: López Serrano
mesh_terms: D000818:Animals; D017129:Anisakiasis / Q000276:immunology*; D017163:Anisakis / Q000276:immunology; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000469:parasitology*; D007073:Immunoglobulin E / Q000032:analysis*; D008875:Middle Aged; D013272:Stomach Diseases / Q000276:immunology* / Q000469:parasitology
chemical_list: D007073:Immunoglobulin E