title: ECVAM's in-house prevalidation/validation studies in the areas of haematotoxicity, reproductive toxicity, metabolism-mediated toxicity and epithelial barrier function.
abstract: The European Centre for the Validation of Alternative Methods (ECVAM) facilitates, co-ordinates and participates in validation activities at the European Union level. Various experimental studies, e.g. in the areas of haematotoxicity, reproductive toxicity, nephrotoxicity and epithelial barrier function, and metabolism-mediated toxicity, are underway in ECVAM's laboratories. ECVAM itself is currently involved in the prevalidation/validation of two assays, the colony-forming unit granulocyte/macrophage (CFU-GM) assays for predicting acute neutropenia and the embryonic stem cell test for predicting embryotoxicity. In the areas of metabolism-mediated toxicity and nephrotoxicity and epithelial barrier function, several assays are in the course of development. In many cases, the recommendations of various ECVAM workshops are being followed.
authors.affiliation: European Commission, Institute for Health and Consumer Protection, Joint Research Centre, ECVAM, Varese, Italy. maria.prieto-pilar@jrc.it
authors.forename: P
authors.initials: P
authors.lastname: Prieto
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D004784:Environmental Monitoring / Q000379:methods* / Q000706:statistics & numerical data; D004785:Environmental Pollutants / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects; D005060:Europe; D005260:Female; D007668:Kidney / Q000187:drug effects; D008297:Male; D015203:Reproducibility of Results; D012098:Reproduction / Q000187:drug effects
chemical_list: D004785:Environmental Pollutants