Interaction of group A streptococci with human plasmin(ogen) under physiological conditions.
A series of methods for analyzing the interaction of group A streptococci with the human plasminogen system are described. Examples of group A streptococcal isolates capable of assembling surface plasminogen activator activity when grown in human plasma are presented and the key requirements for this process are evaluated. The stabilities of cell-associated plasmin and plasminogen activator complexes are compared and a model for the interaction of group A streptococci with the plasminogen system in an infected host is presented.
D'Costa
S S
SS
Department of Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, Ohio 43614-5806, USA.
Boyle
M D
MD
D000328:Adult; D015153:Blotting, Western; D005340:Fibrinogen / Q000378:metabolism / Q000502:physiology; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D010446:Peptide Fragments / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism*; D013290:Streptococcal Infections / Q000097:blood*; D013297:Streptococcus pyogenes / Q000502:physiology*; D013300:Streptokinase / Q000378:metabolism*
D010446:Peptide Fragments; C033809:lys-plasmin; D005340:Fibrinogen; D010958:Plasminogen; D013300:Streptokinase; D005341:Fibrinolysin