title: Angiotensin for septic shock unresponsive to noradrenaline.
abstract: Two children with severe septic shock are reported. One had meningococcal septicaemia and the other Escherichia coli septicaemia. They remained hypotensive despite high concentrations of conventional inotropes and vasopressors. In one child, using a pulmonary artery catheter, extended haemodynamic variables were measured. To restore blood pressure, in both cases, an infusion of angiotensin II was used; there was significant improvement in clinical status, resulting in a rapid reduction in the concentration of inotropes required. Both patients successfully survived their septic episodes. Angiotensin II in cases of severe refractory septic hypotension in the paediatric population offers an extra therapeutic manoeuvre.
authors.affiliation: Paediatric Intensive Care Unit, Great Ormond Street Hospital for Children NHS Trust, London WC1 3JH, UK.
authors.forename: M
authors.initials: M
authors.lastname: Yunge
authors.forename: A
authors.initials: A
authors.lastname: Petros
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology / Q000627:therapeutic use*; D002675:Child, Preschool; D004927:Escherichia coli Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008589:Meningococcal Infections / Q000150:complications*; D009638:Norepinephrine / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy* / Q000503:physiopathology; D017211:Treatment Failure; D014662:Vasoconstrictor Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D009638:Norepinephrine