title: Hyperoxia-enhanced activation-induced hemodynamic response in human VI: an fMRI study.
abstract: The effect hyperoxia had on the hemodynamic response to visual stimulation (black and white checkerboard alternating at a frequency of 8 Hz) of human VI was investigated using a blood oxygenation level-dependent (BOLD) contrast with an fMRI technique. Data were acquired with a 5 on/5 off block paradigm using single-shot gradient-echo echo-planar imaging. Using a two-tailed paired t-test (p < 0.05, n = 13) it was found that the mean percentage signal change and the mean number of activated pixels was significantly increased for hyperoxia (5.7 +/- 0.9, 187 +/- 73, mean +/- SD) relative to those for normoxia (5.4 +/- 0.9, 168 +/- 58). We believe that these results indicate that hyperoxia enhances the activation-induced hemodynamic response in human VI.
authors.affiliation: Akita Laboratory, Japan Science and Technology Corporation (JST), Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kashikura
authors.forename: J
authors.initials: J
authors.lastname: Kershaw
authors.forename: A
authors.initials: A
authors.lastname: Kashikura
authors.forename: T
authors.initials: T
authors.lastname: Matsuura
authors.forename: I
authors.initials: I
authors.lastname: Kanno
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D018496:Hyperoxia / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood; D014793:Visual Cortex / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D010100:Oxygen