title: Pleomorphic xanthoastrocytoma derived from glioneuronal malformation in a child with intractable epilepsy.
abstract: Malformative lesions as well as neoplasms can cause intractable epilepsy in childhood. Even though the neoplastic nature of a lesion is evident in most cases, the distinction can be difficult in some patients. We present the case of a child with intractable epilepsy caused primarily by a glioneuronal malformation. Years after the first surgical intervention, a pleomorphic xanthoastrocytoma evolved from remnants of this lesion. This case suggests that glioneuronal malformations might be precursor lesions of pleomorphic xanthoastrocytomas.
authors.affiliation: Department of Pediatrics, Institute of Pathology, University of Berne, Switzerland.
authors.forename: G P
authors.initials: GP
authors.lastname: Ramelli
authors.forename: N
authors.initials: N
authors.lastname: von der Weid
authors.forename: L
authors.initials: L
authors.lastname: Remonda
authors.forename: L
authors.initials: L
authors.lastname: Mariani
authors.forename: J
authors.initials: J
authors.lastname: Weis
mesh_terms: D001254:Astrocytoma / Q000150:complications* / Q000209:etiology; D001927:Brain Diseases / Q000150:complications / Q000151:congenital*; D001932:Brain Neoplasms / Q000150:complications* / Q000209:etiology; D004827:Epilepsy / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D009457:Neuroglia / Q000473:pathology*