Characterization of a novel polycystic kidney rat model with accompanying polycystic liver.
A polycystic kidney rat model is being established from a Crj:CD (SD) rat strain. Unlike existing animal models of polycystic kidney disease, this mutant rat has a completely polycystic liver. Mating experiments revealed that the phenotype is controlled by an autosomal recessive gene. We propose that this gene be tentatively called the "rpc" gene.
Katsuyama
M
M
Charles River Japan Inc., Kanagawa, Japan.
Masuyama
T
T
Komura
I
I
Hibino
T
T
Takahashi
H
H
D000818:Animals; D003433:Crosses, Genetic; D003560:Cysts / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D008107:Liver Diseases / Q000235:genetics* / Q000473:pathology; D008297:Male; D010641:Phenotype; D007690:Polycystic Kidney Diseases / Q000235:genetics* / Q000473:pathology; D051381:Rats; D011922:Rats, Mutant Strains; D012727:Sex Characteristics