Transgenic studies in rats and mice on the osmotic regulation of vasopressin gene expression.
Over the past 10-15 years, profoundly important transgenic techniques have been developed that enable new genes to be introduced into whole mammalian organisms. This review describes the ways in which transgenic animals, both rats and mice, have been used to study the mechanisms by which the expression of the vasopressin gene is confined to specific neurones in the hypothalamus, and how the pattern of that expression is altered following an osmotic challenge to the organism.
Murphy
D
D
Department of Medicine, Bristol Royal Infirmary, University of Bristol, UK. d.murphy@bristol.ac.uk
Xu
J
J
Waller
S
S
D000818:Animals; D015870:Gene Expression / Q000502:physiology; D007031:Hypothalamus / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D051381:Rats; D014667:Vasopressins / Q000235:genetics*; D014882:Water-Electrolyte Balance / Q000235:genetics*
D014667:Vasopressins