[The use of molecular biological methods for the individual characterization of Mycobacterium tuberculosis strains].
The expediency of using molecular biological methods for the evaluation of M. tuberculosis clinical strains by individual genetic certification of circulating M. tuberculosis strains has been substantiated. Considerable genetic heterogeneity of M. tuberculosis strains isolated from patients in different regions of the Russian Federation has been established; this heterogeneity is due to the presence of differences in the number of copies (5-26) of element IS6110 in M. tuberculosis cells.
Shemiakin
I G
IG
State Research Center of Applied Microbiology, Obolensk, Moscow Region, Russia.
Stepanshina
V N
VN
Manzeniuk
O Iu
OIu
Anisimova
V A
VA
Panfertsev
E A
EA
Korobova
O V
OV
Medvedeva
I M
IM
Dorozhkova
I R
IR
D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D017931:DNA Primers; D004251:DNA Transposable Elements / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D016133:Polymerase Chain Reaction / Q000379:methods / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic / Q000235:genetics; D012426:Russia; D014397:Tuberculosis, Pulmonary / Q000382:microbiology
D017931:DNA Primers; D004251:DNA Transposable Elements; D004269:DNA, Bacterial