Association of coronary heart disease with age-adjusted aortocoronary calcification in patients with familial hypercholesterolaemia.
OBJECTIVE
Existing algorithms of risk of coronary heart disease (CHD) do not pertain to patients with familial hypercholesterolaemia (FH), whose arteries have been exposed to hypercholesterolaemia since birth. We studied a cohort of FH patients to compare four diagnostic models of CHD: traditional risk factors of CHD (age, sex, cholesterol, hypertension, smoking and body mass index), cholesterol year score, and aortic as well as coronary calcium measured by spiral computed tomography (CT).


METHODS
We invited 88 individuals with molecularly defined FH of whom 80 (91%) decided to participate.


RESULTS
Analysis of receiver operating characteristic curves showed that the age-adjusted coronary calcium score was more strongly associated with clinical manifestations of CHD than were traditional risk factors (P < 0.002), cholesterol year score (P << 0.0001), and the age-adjusted aortic calcium score (P < 0.0004).


CONCLUSIONS
Age-adjusted coronary calcium score shows promise as an indicator of CHD in FH patients.
Jensen
J M
JM
Departments of Cardiology and Radiology, Aarhus Amtssygehus University Hospital, Aarhus, Denmark. jmj@post7.tele.dk
Gerdes
L U
LU
Jensen
H K
HK
Christiansen
T M
TM
Brorholt-Petersen
J U
JU
Faergeman
O
O
D000328:Adult; D000367:Age Factors; D000368:Aged; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000235:genetics*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000235:genetics*; D015331:Cohort Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000235:genetics*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000000981:diagnostic imaging / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors; D014057:Tomography, X-Ray Computed