title: Nasal natural killer cell lymphoma in a post-renal transplant patient.
abstract: Posttransplant lymphoproliferative disorders in organ allograft recipients are most commonly of B-cell origin and only occasionally of T-cell origin. We present here a case of nasal natural killer cell lymphoma associated with Epstein-Barr virus that occurred in a recipient of a renal transplant 4 years posttransplantation. Immunohistochemically, the lymphoma cells showed CD2-, surface CD3-, cytoplasmic CD3E+, CD56+, CD57-, CD16-, and CD43+ phenotype. Analyses of T-cell receptor beta and gamma genes showed germ line configurations. EBER-1 was detectable in the lymphoma cells. The patient was diagnosed as having natural killer cell lymphoma and was treated with six courses of combination chemotherapy for non-Hodgkin's lymphoma He has been in remission for more than 3 years thereafter. To the best of our knowledge, this is the first report of a posttransplant NK cell lymphoma associated with Epstein-Barr virus.
authors.affiliation: Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
authors.forename: H Y
authors.initials: HY
authors.lastname: Mukai
authors.forename: H
authors.initials: H
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Suzukawa
authors.forename: M
authors.initials: M
authors.lastname: Hori
authors.forename: T
authors.initials: T
authors.lastname: Komeno
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: H
authors.initials: H
authors.lastname: Ninomiya
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D009296:Nasal Cavity / Q000473:pathology; D009669:Nose Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D011183:Postoperative Complications; D012367:RNA, Viral / Q000032:analysis
chemical_list: D015703:Antigens, CD; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral