Increase in CD3+ CD4- T lymphocytes in patients with AIDS and disseminated Mycobacterium avium-intracellulare complex infection: a prospective study. GECSA. Groupe d'Epidemiologie Clinique du SIDA en Aquitaine.
In a retrospective study, an increase in double-negative (CD3+ CD4- CD8-) (DN) T lymphocytes has been shown to be an independent predictor of disseminated Mycobacterium avium complex (D.MAC) infection in patients with less than 100 CD4+ T cells per mm3. To better characterize this cell expansion, a prospective study was designed. From July 1995 to April 1997, 206 HIV-infected patients with less than 100 CD4+ T cells per mm3 were prospectively followed up and immunophenotyped. The median followup was 1.1 year (+/-0.5 year), and 14 new D.MAC infections were diagnosed among 84 first AIDS-defining events. In univariate and multivariate analyses, D.MAC infections were the only opportunistic infection with a significant increase in DN T-cell percentage (median = 6.6; range = 1.7 to 24.5, P = 0.004) compared with patients without any opportunistic infection. This alteration in T-lymphocyte count could constitute a predictor for D.MAC infection in clinical practice.
Bonnet
F
F
Service de médecine interne et maladies infectieuses, Hôpital du Haut-Lévêque, CHU Bordeaux, France.
Dequae-Merchadou
L
L
Taupin
J L
JL
Sire
S
S
Dupon
M
M
Ragnaud
J M
JM
Lacoste
D
D
Texier-Maugein
J
J
Romagné
F
F
Dabis
F
F
Pellegrin
J L
JL
Moreau
J F
JF
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000276:immunology*; D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015331:Cohort Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015270:Mycobacterium avium-intracellulare Infection / Q000150:complications / Q000276:immunology*; D011446:Prospective Studies; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D017252:CD3 Complex