title: Abnormal distribution of CD45 isoforms expressed by CD4+ and CD8+ T cells in rheumatoid arthritis.
abstract: CD45RO+ T cells are referred to as memory or helper-inducer while CD45RA+ T cells are regarded as naive or suppressor-inducer T cells. The former population predominates in the peripheral blood and even more in the synovial fluid of patients with rheumatoid arthritis, to the expense of the latter population. Within the CD45RB+ compartment, there appears to be more of the fully-differentiated than of the early-differentiated CD4+ T cells. In spite of the fact that these lymphocytes are close to undergoing apoptosis, this programmed cell death is inhibited in the rheumatoid synovium.
authors.affiliation: Laboratory of Immunology, Brest University Medical School, France.
authors.forename: A
authors.initials: A
authors.lastname: Mamoune
authors.forename: V
authors.initials: V
authors.lastname: Durand
authors.forename: P
authors.initials: P
authors.lastname: Le Goff
authors.forename: Y L
authors.initials: YL
authors.lastname: Pennec
authors.forename: P
authors.initials: P
authors.lastname: Youinou
authors.forename: R
authors.initials: R
authors.lastname: Le Corre
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens / Q000276:immunology* / Q000378:metabolism; D020033:Protein Isoforms / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D014018:Tissue Distribution; D019014:fas Receptor / Q000276:immunology
chemical_list: D020033:Protein Isoforms; D019014:fas Receptor; D017493:Leukocyte Common Antigens