title: Clinical study on chronopharmacokinetics of digoxin in patients with congestive heart failure.
abstract: Fluorescence polarization immunoassay was used to study the chronopharmacokinetics of digoxin in 10 patients with congestive heart failure (CHF) who also served as self-controls. Our results showed that the serum digoxin concentration reached peak value 1 h after taking digoxin at 7:00 a.m., but the serum digoxin concentration reached the peak value 2 h after taking digoxin at 4:00 p.m. The average serum digoxin concentration area under curve was greater and the best maintainable time of serum concentration within 24 h after taking digoxin at 4 p.m. longer than those at 7:00 a.m. The heart rates were obviously lower and the cardiac function was significantly improved in 4:00 p.m. group.
authors.affiliation: Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan.
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Fang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: T
authors.initials: T
authors.lastname: Zhu
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D019454:Chronotherapy; D003327:Coronary Disease / Q000150:complications; D004077:Digoxin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000150:complications
chemical_list: D004077:Digoxin