title: Rifampicin-resistant bacteriophage PBS2 infection and RNA polymerase in Bacillus subtilis.
abstract: Bacteriophage PBS2 replication is unaffected by rifampicin and other rifamycin derivatives, which are potent inhibitors of Bacillus subtilis RNA synthesis. Extracts of gently-lysed infected cells contain a DNA-dependent RNA polymerase activity which is specific for uracil-containing PBS2 DNA. The PBS2-induced RNA polymerase is insensitive to rifamycin derivatives which inhibit the host's RNA polymerase.
authors.forename: A R
authors.initials: AR
authors.lastname: Price
authors.forename: R
authors.initials: R
authors.lastname: Hitzeman
authors.forename: J
authors.initials: J
authors.lastname: Frato
authors.forename: K
authors.initials: K
authors.lastname: Lombardi
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017103:Bacillus Phages / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D001412:Bacillus subtilis / Q000201:enzymology / Q000821:virology*; D002701:Chloramphenicol / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D008154:Lucanthone / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology*; D012294:Rifamycins / Q000494:pharmacology; D013310:Streptovaricin / Q000494:pharmacology; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012294:Rifamycins; D014764:Viral Proteins; D013310:Streptovaricin; D003609:Dactinomycin; D002701:Chloramphenicol; C100307:streptolydigin; D012321:DNA-Directed RNA Polymerases; D008154:Lucanthone; D012293:Rifampin