Regioselective synthesis of beta-N1- and beta-N3-alloxazine nucleosides
[structures: see text] A regio- and stereoselective glycosylation of ribose tetraester with persilylated alloxazine to give either beta-N1 or beta-N3 nucleosides is described. The N3 product is potentially of interest as a fluorescent nucleoside and is predicted to have the hydrogen-bonding characteristics of thymidine.
Wang
Z
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA.
Rizzo
CJ