Human papillomavirus in head and neck carcinomas: prevalence, physical status and relationship with clinical/pathological parameters.
The association of human papillomavirus (HPV) infection to head and neck squamous cell carcinomas was evaluated in 66 patients affected by tumours of the oral cavity (n = 38), the tonsil (n = 4), the pharynx (n = 2), and the larynx (n = 22). HPV DNA was detected by PCR-based assays, recognizing late and early genes. Twenty-four cases were HPV infected (36.4%), mostly by high and/or intermediate risk types. HPV 16 was integrated in 7/12 positive tumours without site-specificity. HPV infection was not related to age, gender, tumour stage, differentiation grade, and use of alcohol and/or tobacco. The findings indicate that HPV infection may be related to a proportion of head and neck carcinomas but its association is not as clear as that found in cervical cancer.
Badaracco
G
G
Laboratory of Virology, Regina Elena Cancer Institute, Rome, Italy. badaracco@crs.ifo.it
Venuti
A
A
Morello
R
R
Muller
A
A
Marcante
M L
ML
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000821:virology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D010610:Pharyngeal Neoplasms / Q000150:complications / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D012907:Smoking; D014067:Tonsillar Neoplasms / Q000150:complications / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology
D004279:DNA, Viral