Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics.
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D000818:Animals; D004777:Environment; D030342:Genetic Diseases, Inborn / Q000235:genetics* / Q000503:physiopathology*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D013577:Syndrome