[Photoactivated derivatives of peptide and protein ligands in the studies of neuroreceptors].
The application of photoactivatable derivatives for studies of different types of neuroreceptors belonging to two superfamilies, G-protein dependent receptors and ligand-gated ionic channels, is discussed. Studies of the structure of voltage-gated and ion-gated channels with the use of specific photoactivatable derivatives of neurotoxins are also described. Possibilities and prospects for the application of photoactivatable ligands in studies of the spatial structure of neuroreceptors are reviewed.
Utkin
Iu N
IuN
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. utkin@ibch.siobc.ras.ru
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D009420:Nervous System / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry*; D010775:Photic Stimulation; D011506:Proteins / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism
D007473:Ion Channels; D008024:Ligands; D010455:Peptides; D011506:Proteins; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins