APHE-3, a spore-associated antibiotic of Streptomyces griseocarneus NCIMB 40447.
Solid cultures of the producing strain grown on Bennett medium develop abundant mycelium and intense sporulation. Under these conditions biosynthesis of APHE antibiotics (APHE-1 to -3) is accomplished. Further studies show that APHE-3 is basically produced during spore formation and mostly present in spores, while APHE-1 and APHE-2 are the predominant antibiotics in the mycelium. APHE compounds are present in almost all streptomycetes tested, indicating a possible role in the life cycle of these microorganisms.
Cruz
R
R
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá, Madrid, Spain.
Arias
M E
ME
Soliveri
J
J
D002851:Chromatography, High Pressure Liquid; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism*; D011720:Pyrazoles / Q000737:chemistry / Q000378:metabolism; D013171:Spores, Bacterial / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism* / Q000502:physiology
D007546:Isoquinolines; D011720:Pyrazoles; C101455:antibiotic APHE 3