title: Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva.
abstract: Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.
authors.affiliation: Department of Biology, University of York, PO Box 373, York, Y010 5YW, UK.
authors.forename: R
authors.initials: R
authors.lastname: Hall
authors.forename: N R
authors.initials: NR
authors.lastname: Boulter
authors.forename: C G
authors.initials: CG
authors.lastname: Brown
authors.forename: G
authors.initials: G
authors.lastname: Wilkie
authors.forename: E
authors.initials: E
authors.lastname: Kirvar
authors.forename: V
authors.initials: V
authors.lastname: Nene
authors.forename: A J
authors.initials: AJ
authors.lastname: Musoke
authors.forename: E J
authors.initials: EJ
authors.lastname: Glass
authors.forename: S P
authors.initials: SP
authors.lastname: Morzaria
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan; D002417:Cattle; D007115:Immunization Schedule; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D016796:Theileria annulata / Q000254:growth & development / Q000276:immunology*; D016797:Theileria parva / Q000254:growth & development / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011994:Recombinant Proteins; C114309:p67 antigen, Theileria; C091729:SPAG-1 antigen, Theileria annulata