title: Reversible tobramycin-induced bilateral high-frequency vestibular toxicity.
abstract: We report an unusual case of tobramycin-induced bilateral high-frequency vestibular toxicity with subsequent clinical and objective evidence of functional recovery. In those patients with a clinical presentation suggestive of aminoglycoside-induced bilateral vestibular toxicity (ataxia and oscillopsia) and normal low-frequency (ENG-caloric) responses, high-frequency rotation chair testing should be performed to exclude a high-frequency vestibular deficit.
authors.affiliation: Department of Otolaryngology, University Health Network, Toronto General Hospital, University of Toronto, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Walsh
authors.forename: A P
authors.initials: AP
authors.lastname: Bath
authors.forename: M L
authors.initials: ML
authors.lastname: Bance
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000382:microbiology; D011552:Pseudomonas Infections; D020127:Recovery of Function; D014031:Tobramycin / Q000009:adverse effects*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects* / Q000503:physiopathology*
chemical_list: D000900:Anti-Bacterial Agents; D014031:Tobramycin