title: [Disseminated acute encephalomyelitis in children. A retrospective study of seven patients].
abstract: OBJECTIVE
  Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system. This study is based on clinical symptoms and diagnostic tests employed.
  
  
  METHODS
  We describe a seven children series indicating the initial neurologic abnormalities, diagnostic tests, treatments used and clinical-neuroradiological evolution.
  
  
  RESULTS
  The mean presentation age was 4.1 years. Initial neurologic symptoms were mainly spastic hemi/paraparesis, cerebellous and pyramidal syndrome, consciousness changes, meningeal signs, seizures and cranial nerve palsies. The cerebrospinal fluid was abnormal in four patients with positive serologic tests in two of them (Coxsackie B). Electrophysiological studies were affected in 50%. MRI findings consisted of multifocal supratentorial white matter lesions. Clinical evolution revealed a progressive improvement with resolution after two months. Follow-up was made between six months and five years. The treatment was based on aciclovir and corticosteroids.
  
  
  CONCLUSIONS
  ADEM runs a monophasic course of progressive neurologic abnormalities. Diagnosis is based on suggestive clinical and neuroimaging findings. Generally speaking, MRI showed resolution of multifocal lesions in conjunction with clinical improvement.
authors.affiliation: Servicio de Pediatría, Hospital Virgen de Los Lirios, Alcoy, Alicante. fagomezgos@coma.es
authors.forename: F A
authors.initials: FA
authors.lastname: Gómez-Gosálvez
authors.forename: P
authors.initials: P
authors.lastname: Smeyers
authors.forename: F
authors.initials: F
authors.lastname: Menor
authors.forename: A
authors.initials: A
authors.lastname: Morant
authors.forename: J
authors.initials: J
authors.lastname: Carbonell
authors.forename: F
authors.initials: F
authors.lastname: Mulas
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001480:Basal Ganglia Diseases / Q000175:diagnosis / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018450:Disease Progression; D004673:Encephalomyelitis, Acute Disseminated / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009128:Muscle Spasticity / Q000175:diagnosis / Q000209:etiology; D010291:Paresis / Q000175:diagnosis / Q000209:etiology; D011859:Radiography; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013116:Spinal Cord / Q000473:pathology; D013256:Steroids; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D013256:Steroids; D000212:Acyclovir