title: Development of an automated synthesis apparatus for L-[3-11C] labeled aromatic amino acids.
abstract: We have developed an automated synthesis apparatus for L-[3-11C]-labeled aromatic amino acids by improved multi-enzymatic reactions. Use of a specially designed reaction vessel and of CH2Cl2 as a solvent has greatly simplified the overall operation, proving to be suitable for automated synthesis, and also has given better yields and higher specific activities than formerly reported values.
authors.affiliation: Central Research Lahoratory, Hamamatsu Photonics K.K., Hamakita, Shizuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Nishiyama
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Tsukada
mesh_terms: D006916:5-Hydroxytryptophan / Q000138:chemical synthesis; D000409:Alanine / Q000138:chemical synthesis; D000598:Amino Acids, Cyclic / Q000138:chemical synthesis*; D001331:Automation; D002250:Carbon Radioisotopes; D004295:Dihydroxyphenylalanine / Q000138:chemical synthesis; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods*
chemical_list: D000598:Amino Acids, Cyclic; D002250:Carbon Radioisotopes; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D000409:Alanine