Prescribing trends in the treatment of acute otitis media. Reining in resistant bacteria.
Several factors influence antimicrobial selection when treating otitis media. In addition to good in vitro activity against common pathogens, the drug should be well-absorbed with high serum concentrations and good penetration to the site of infection. Oral amoxicillin dosed at 40 mg/kg/day to 50 mg/kg/day every 8 hours for 10 days remains first-line therapy for uncomplicated AOM. Second-line agents to treat AOM can include second- and third-generation cephalosporins. The rapid emergence of antibiotic-resistant bacteria represents a particular problem because these pathogens cause not only otitis media but more serious and invasive bacterial infections such as pneumonia, bacteremia and meningitis.
Kujdych
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University of Mississippi School of Pharmacy, Jackson, USA.
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D002675:Child, Preschool; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004352:Drug Resistance, Microbial; D004363:Drug Utilization / Q000706:statistics & numerical data* / Q000639:trends*; D006801:Humans; D007223:Infant; D009722:Nurse Practitioners; D010033:Otitis Media / Q000188:drug therapy* / Q000382:microbiology*; D018579:Patient Selection; D017211:Treatment Failure
D000900:Anti-Bacterial Agents