title: APHE-3, a spore-associated antibiotic of Streptomyces griseocarneus NCIMB 40447.
abstract: Solid cultures of the producing strain grown on Bennett medium develop abundant mycelium and intense sporulation. Under these conditions biosynthesis of APHE antibiotics (APHE-1 to -3) is accomplished. Further studies show that APHE-3 is basically produced during spore formation and mostly present in spores, while APHE-1 and APHE-2 are the predominant antibiotics in the mycelium. APHE compounds are present in almost all streptomycetes tested, indicating a possible role in the life cycle of these microorganisms.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad de Alcalá, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Cruz
authors.forename: M E
authors.initials: ME
authors.lastname: Arias
authors.forename: J
authors.initials: J
authors.lastname: Soliveri
mesh_terms: D002851:Chromatography, High Pressure Liquid; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism*; D011720:Pyrazoles / Q000737:chemistry / Q000378:metabolism; D013171:Spores, Bacterial / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism* / Q000502:physiology
chemical_list: D007546:Isoquinolines; D011720:Pyrazoles; C101455:antibiotic APHE 3