[Synthesis and local and distant actions of vasoactive peptides].
In this short review, we compare the structure, biosynthetis and processing pathways, physiological actions, receptor systems and signaling pathways of 3 vasoactive peptides: vasopressin, angiotensin II and endothelins. This comparison shows clearly that all these peptides are synthesized as preproproteins and are processed by proteolytic enzymes. They all act via different types of membrane-bound G protein coupled receptors. Their actions on cardiovascular target tissues are either of an endocrine nature (vasopressin) or a paracrine nature (endothelins) or both (angiotensin II).
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INSERM U36, Collège de France, 3, rue d'Ulm 75005 Paris et Faculté de Médecine Saint-Antoine, 75012 Paris, France.
D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D016232:Endothelins / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008969:Molecular Sequence Data; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000502:physiology; D017466:Receptors, Endothelin / Q000187:drug effects / Q000502:physiology; D017483:Receptors, Vasopressin / Q000187:drug effects / Q000502:physiology; D014662:Vasoconstrictor Agents; D014667:Vasopressins / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology
D016232:Endothelins; D011945:Receptors, Angiotensin; D017466:Receptors, Endothelin; D017483:Receptors, Vasopressin; D014662:Vasoconstrictor Agents; D014667:Vasopressins; D000804:Angiotensin II