title: Formal synthesis of (+/-)-peduncularine: use of the
abstract: [reaction: see text] The formal synthesis of the alkaloid (+/-)-peduncularine (1) was accomplished through the use of a [3 + 2] allylic silane annulation. The annulation of cyclohexadienyl silane 6 with chlorosulfonyl isocyanate followed by an in situ reduction provided bicyclic lactam 7. Conversion of this intermediate to 2 in three steps completed the formal synthesis of (+/-)-peduncularine.
authors.affiliation: Department of Chemistry, University of California, Irvine 92697-2025, USA.
authors.initials: CW
authors.lastname: Roberson
authors.initials: KA
authors.lastname: Woerpel