title: Prescribing trends in the treatment of acute otitis media. Reining in resistant bacteria.
abstract: Several factors influence antimicrobial selection when treating otitis media. In addition to good in vitro activity against common pathogens, the drug should be well-absorbed with high serum concentrations and good penetration to the site of infection. Oral amoxicillin dosed at 40 mg/kg/day to 50 mg/kg/day every 8 hours for 10 days remains first-line therapy for uncomplicated AOM. Second-line agents to treat AOM can include second- and third-generation cephalosporins. The rapid emergence of antibiotic-resistant bacteria represents a particular problem because these pathogens cause not only otitis media but more serious and invasive bacterial infections such as pneumonia, bacteremia and meningitis.
authors.affiliation: University of Mississippi School of Pharmacy, Jackson, USA.
authors.forename: N
authors.initials: N
authors.lastname: Kujdych
mesh_terms: D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology*; D002675:Child, Preschool; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004352:Drug Resistance, Microbial; D004363:Drug Utilization / Q000706:statistics & numerical data* / Q000639:trends*; D006801:Humans; D007223:Infant; D009722:Nurse Practitioners; D010033:Otitis Media / Q000188:drug therapy* / Q000382:microbiology*; D018579:Patient Selection; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents