title: [Endothelins--their physiological role and their clinical significance].
abstract: Biochemical part of the paper presents the structure, biosynthesis and degradation of the endothelins. Physiological chapter deals with endothelin-1 endocrine and mitogenic action as well as its impact on diuresis, natriuresis and cardiovascular system. In the clinical part of the article the role of endothelin-1 in essential hypertension, congestive heart failure and chronic renal failure is described.
authors.affiliation: Katedry i Zakładu Biochemii, Akademii Medycznej w Gdańsku.
authors.forename: K
authors.initials: K
authors.lastname: Kaletha
authors.forename: Z
authors.initials: Z
authors.lastname: Chodorowski
authors.forename: B
authors.initials: B
authors.lastname: Wyrzykowski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D004231:Diuresis / Q000502:physiology; D016232:Endothelins / Q000502:physiology*; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000503:physiopathology; D009318:Natriuresis / Q000502:physiology
chemical_list: D016232:Endothelins