[The role of protein synthesis in realisation of protective cardiac effects of thyroid hormones during immobilization stress in rats].
A decrease in the protein synthesis by the transcription inhibitor rifampycin prevents myocardial contractile function, protective effect of thyroid hormones and their antioxidant effect under the restraint stress in rats. The findings suggest that the main component of thyroid hormones' protective effect on the heart is related to their specific action realised via the cell genetic apparatus.
Gorodetskaia
I V
IV
Medical Institute, Vitebsk, Belorussia.
Bozhko
A P
AP
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007103:Immobilization; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D014176:Protein Biosynthesis; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D012293:Rifampin / Q000494:pharmacology; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000494:pharmacology*; D014158:Transcription, Genetic
D000975:Antioxidants; D011500:Protein Synthesis Inhibitors; D013963:Thyroid Hormones; D012293:Rifampin