Prolonged deafness limits auditory system developmental plasticity: evidence from an evoked potentials study in children with cochlear implants.
The use of cochlear implants to restore hearing in profoundly deaf children is increasing, with a trend toward earlier implantation. However, little is known about how auditory deprivation and subsequent implant use affects the maturing central auditory system. Previously reported results indicate that stimulation of the auditory system by a cochlear implant is sufficient to restore at least some aspects of central auditory pathway maturation, as reflected by age-related changes in the auditory evoked potentials. We review animal and human studies on sensory deprivation and report new results based on longitudinal evoked potentials data recorded from two individuals. Analyses show that age-related changes in the EPs may asymptote at levels very different from those found in the adult normal-hearing population. These results suggest that maturation of at least some aspects of central auditory system activity is limited by the onset and duration of the period of deafness prior to implantation.
Ponton
C W
CW
House Ear Institute, Los Angeles, California, USA.
Moore
J K
JK
Eggermont
J J
JJ
D000328:Adult; D001303:Auditory Cortex / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D019929:Cochlear Implantation; D003638:Deafness / Q000175:diagnosis / Q000601:surgery*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D012720:Severity of Illness Index; D013997:Time Factors