Investigation on the mechanism involved in the effects of agmatine on ethanol-induced gastric mucosal injury in rats.
Effects of agmatine, an endogenous metabolite formed by decarboxylation of L-arginine, on ethanol-induced gastric mucosal injury were investigated in rats. Agmatine at 1 and 10 mg/kg i.p doses significantly increased ethanol-induced gastric mucosal injury. This effect of agmatine was abolished completely by pretreatment with idazoxan, an imidazoline receptor-antagonist and alpha2 receptor- antagonist, (0.5 mg/kg i.p), partly by yohimbine, an alpha2 receptor- antagonist, (1 mg/kg i.p) but not by L-arginine, a precursor of nitric oxide, (500 mg/kg i.p). Our results suggest that agmatine had a potent ulcerogenic effect mediated, at least in part, by both alpha2-adrenoceptors and imidazoline receptors.
Utkan
T
T
Department of Pharmacology, Kocaeli University, Faculty of Medicine, Turkey. tijenutkan@superonline.com
Ulak
G
G
Yildiran
H G
HG
Yardimoglu
M
M
Gacar
M N
MN
D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000376:Agmatine / Q000494:pharmacology*; D000818:Animals; D002492:Central Nervous System Depressants; D000431:Ethanol; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000503:physiopathology; D019329:Idazoxan / Q000494:pharmacology; D054755:Imidazoline Receptors; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects*; D011955:Receptors, Drug / Q000037:antagonists & inhibitors / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D015016:Yohimbine / Q000494:pharmacology
D058669:Adrenergic alpha-2 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D002492:Central Nervous System Depressants; D054755:Imidazoline Receptors; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; D015016:Yohimbine; D009569:Nitric Oxide; D000431:Ethanol; D000376:Agmatine; D019329:Idazoxan