Macromolecular mimicry of nucleic acid and protein.
Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecular mimicry. Macromolecular mimicry has further been proposed among initiation and release factors, thereby adding a new element to the description of protein synthesis in bacteria. Such mimicry has also been observed in other biological processes such as autoimmunity, DNA repair, and gene regulation, at both transcriptional and translational levels.
Pedersen
G N
GN
Institute for Molecular and Structural Biology, Aarhus, Denmark.
Nyborg
J
J
Clark
B F
BF
D000818:Animals; D004247:DNA / Q000737:chemistry*; D005786:Gene Expression Regulation; D006801:Humans; D008958:Models, Molecular; D018716:Molecular Mimicry; D009690:Nucleic Acid Conformation; D010445:Peptide Elongation Factors / Q000737:chemistry; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D010445:Peptide Elongation Factors; D011506:Proteins; D012313:RNA; D004247:DNA