[Anti-inflammatory activity of the bark of Khaya senegalensis (A Juss). Preliminary research of structure/activity relationship].
Some anti-inflammatory tests based on the carrageenan induced oedema rat paw method have been carried out with a freeze-dried aqueous extract and an etheropetrolic extract of Cailcedrat (Khaya senegalensis) barks. Then, a preliminary chemical study to find a relation structure/activity has been done from the etheropetrolic extract, by using various chromatography technicals. The achieved results have shown a decrease of the oedema by 14% when the aqueous extract is used at 1 g.kg-1, 21.5% and 62% with the etheropetrolic extract used at the respecive doses of 0.5 g.kg-1 and 1 g.kg-1. As for the chemical study, it allowed the separation of two compounds which probably take part in noticed activity and are supposed to be methyl angolensate and methyl hydroxyangolensate.
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Laboratoire de Pharmacie Galénique, Faculté de Médecine et de Pharmacie de Dakar, Sénégal.
Pousset
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D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000627:therapeutic use*; D002351:Carrageenan; D002845:Chromatography; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012675:Senegal; D013329:Structure-Activity Relationship; D014197:Trees
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan