Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation.
Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing alpha-D-galactose by various NMR spectral analyses and chemical degradation.
Takahashi
S
S
Department of Biosciences, Teikyo University, Utsunomiya, Japan.
Nakano
T
T
Koiwa
T
T
Noshita
T
T
Funayama
S
S
Koshino
H
H
Nakagawa
A
A
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects; D016169:Lymphocyte Function-Associated Antigen-1 / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D016169:Lymphocyte Function-Associated Antigen-1; D010545:Peroxides; D014966:Xanthenes; C406042:adxanthromycin A; C406043:adxanthromycin B; D018799:Intercellular Adhesion Molecule-1