Pregnancy outcome in women with primary renal disease.
BACKGROUND
The preconception and intraconception parameters that are relevant to outcome in women with underlying renal disease remain controversial.


OBJECTIVE
To analyze the types and frequencies of short- and long-term (2 years after delivery) maternal and neonatal complications in 38 patients with primary renal disease (46 pregnancies), most of them with mild renal insufficiency.


METHODS
Logistic regression models were formulated to predict successful outcome.


RESULTS
Successful pregnancy outcome (live, healthy infant without severe handicap 2 years after delivery) was observed in 98% of the patients with primary renal disease. Factors found to be significantly predictive of successful outcome were absence of pre-existing hypertension, in addition to low preconception serum uric acid level.


CONCLUSIONS
Most women with primary renal disease who receive proper prenatal care have a successful pregnancy outcome. Worse pregnancy outcome was observed in women with moderate or severe renal failure. Fitted logistic models may provide useful guidelines for counseling women with preexisting renal disease about their prospects for a successful pregnancy in terms of immediate and long-term maternal and neonatal outcome.
Bar
J
J
Department of Obstetrics and Gynecology, Rabin Medical Center (Beilinson Campus), Petah Tiqva, Israel. bar1@netvision.net.il
Orvieto
R
R
Shalev
Y
Y
Peled
Y
Y
Pardo
Y
Y
Gafter
U
U
Ben-Rafael
Z
Z
Chen
R
R
Hod
M
M
D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000150:complications* / Q000175:diagnosis; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011379:Prognosis