[Serum concentration of insulin-like growth factor-I in cord blood].
OBJECTIVE
To evaluate the role of insulin-like growth factor-I (IGF-I) in fetal growth and placental growth.


METHODS
Cord blood IGF-I was determined by radioimmunoassay (RIA) after serum samples were extracted with acid-ethanol. Linear correlation between variables was tested by calculating pearson's correlation coefficient. student's test was used to compare mean values between groups.


RESULTS
In 102 tested samples, the concentration of cord blood serum IGF-I was correlated with the gestational age, the birth weight of neonates and placental weight (r = 0.32, P < 0.001, r = 0.68, P < 0.001, r = 0.75, P < 0.001). The mean serum level of IGF-I in the small-for-gestational-age (SGA) neonates was significantly lower than that in average-for gestational-age (AGA) (t = 4.77, P < 0.001), But the serum concentration of IGF-I in the Large-for-gestational-aga (LGA) neonates was significantly higher than that of AGA neonates (t = 7.97, P < 0.001).


CONCLUSIONS
Those results suggested that IGF-I is an important regulator for fetal and placental growth and development. It has the key role for macrosomia and IUGR forming.
Wan
G
G
First Affiliated Hospital, Nanjing Medical University.
Yu
S
S
Liu
J
J
D000328:Adult; D001724:Birth Weight; D005314:Embryonic and Fetal Development; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005317:Fetal Growth Retardation / Q000097:blood; D005320:Fetal Macrosomia / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D010929:Placentation; D011247:Pregnancy; D011863:Radioimmunoassay
D007334:Insulin-Like Growth Factor I