Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.
Bouchon
A
A
Basel Institute for Immunology, Basel, Switzerland.
Dietrich
J
J
Colonna
M
M
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D015415:Biomarkers / Q000097:blood; D020013:Calcium Signaling / Q000276:immunology; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005658:Fungi / Q000276:immunology; D006090:Gram-Negative Bacteria / Q000276:immunology; D006094:Gram-Positive Bacteria / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D008262:Macrophage Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000097:blood; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D005810:Multigene Family / Q000276:immunology; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D010766:Phosphorylation; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics / Q000502:physiology*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014443:Tyrosine / Q000097:blood; D015854:Up-Regulation / Q000276:immunology
D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; C498715:TREM2 protein, human; C110546:TYROBP protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014443:Tyrosine