CCK/dopamine interactions in Fawn-Hooded and Wistar-Kyoto rat brain.
The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K(+) stimulated release of [(3)H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 microM) caused a significant decrease of evoked [(3)H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon.
Lodge
D J
DJ
Department of Pharmacology, Monash University, Wellington Road, Clayton, Victoria, Australia.
Short
J L
JL
Mercer
L D
LD
Beart
P M
PM
Lawrence
A J
AJ
D000428:Alcohol Drinking; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology; D010671:Phenylurea Compounds / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011921:Rats, Inbred WKY; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology; D013758:Tetragastrin / Q000494:pharmacology
C090019:8-sulfocholecystokinin octapeptide; D001570:Benzodiazepinones; D018697:Nootropic Agents; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C058121:L 365260; D012844:Sincalide; D004298:Dopamine