Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.
[reaction: see text] Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated. This pathway illustrates a key element in a planning algorithm for diversity-oriented synthesis. This element facilitates the efficient synthesis of structurally complex compounds, and it can be integrated with ones that provide structurally diverse compounds.
Lee
D
D
Howard Hughes Medical Institute, Department of Chemistry & Chemical Biology, Harvard Institute of Chemistry & Cell Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Sello
J K
JK
Schreiber
S L
SL
D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
D009930:Organic Chemicals