title: Barrier recovery rate varies time-dependently in human skin.
abstract: The recovery in cutaneous barrier functions, assessed in terms of transepidermal water loss, 1 h after tape stripping of volar forearm skin in human volunteers, was investigated at different times over the 24 h day. The barrier recovery rate was significantly lower between 20:00 h and 23:00 h than that at other time points. The skin surface temperature and the basal transepidermal water loss reached their highest values at about 03:00 h (33.6 degrees C and 0.30 mg cm-2 h-1), while the cortisol level in the saliva was highest at 09:00 h (7.8 pmol mL-1). These results suggest significant time-dependent variation in cutaneous barrier repair independent of changes in skin temperature and cortisol level.
authors.affiliation: Shiseido Research Center 2 2-12-1 Fukuura, Kanazawa-ku, Yokohama, 236-8643 Japan. mitsuhiro.denda@to.shiseido.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Denda
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
mesh_terms: D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D008297:Male; D020127:Recovery of Function / Q000502:physiology*; D012463:Saliva / Q000737:chemistry; D012869:Skin Absorption / Q000502:physiology; D012879:Skin Physiological Phenomena / Q000187:drug effects; D012881:Skin Temperature / Q000502:physiology; D014870:Water Loss, Insensible / Q000502:physiology*
chemical_list: D006854:Hydrocortisone