title: Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis.
abstract: We report a case of reversible acute renal failure after cefotaxime treatment in a patient affected by non-Hodgkin lymphoma. Renal biopsy showed necrotizing vasculitis associated with eosinophil-rich interstitial inflammatory infiltrates and patchy infiltrates of CD20+ lymphoid cells. High serum p-ANCA titers were also detected. Drug withdrawal was closely related with recovery of renal function and disappearance of ANCA. Acute renal failure therefore represented a consequence of ANCA-mediated renal vasculitis and acute interstitial nephritis related to cefotaxime treatment.
authors.affiliation: Nefrologia e Dialisi, Ospedale Belcolle, Viterbo, Italy. ancarani@isa.it
authors.forename: S
authors.initials: S
authors.lastname: Feriozzi
authors.forename: A O
authors.initials: AO
authors.lastname: Muda
authors.forename: V
authors.initials: V
authors.lastname: Gomes
authors.forename: M
authors.initials: M
authors.lastname: Montanaro
authors.forename: T
authors.initials: T
authors.lastname: Faraggiana
authors.forename: E
authors.initials: E
authors.lastname: Ancarani
mesh_terms: D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002511:Cephalosporins / Q000009:adverse effects*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D009195:Peroxidase / Q000276:immunology*; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D015415:Biomarkers; D002511:Cephalosporins; D009195:Peroxidase