title: Adult-onset giant juxtaglomerular cell tumor of the kidney.
abstract: The juxtaglomerular cell tumor (JGCT) of the kidney is a rare neoplasm which commonly secretes renin. This tumor often occurs in teenagers. This paper documents the 14th adult-onset (over 30-years-old) case with a giant JGCT which measured 9.0 x 8.0 x 7.5 cm. Histologically, this tumor was composed of both vascular and tubular components. Immunohistochemically, the vascular component reacted with renin, cytokeratin 7, ulex europaeus agglutinin-1, vascular endothelial growth factor (VEGF) and Flk-1 (VEGF-R2), whereas the tubular component was positive for renin, epithelial membrane antigen (EMA), cytokeratin 7, alpha-1-antitrypsin, VEGF and Flk-1. This finding suggests that both vascular and tubular components of JGCT may promote neoplastic proliferation via an autocrine mechanism through the action of VEGF.
authors.affiliation: First Department of Pathology, Kochi Medical School, Kochi, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kuroda
authors.forename: T
authors.initials: T
authors.lastname: Moriki
authors.forename: F
authors.initials: F
authors.lastname: Komatsu
authors.forename: E
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Naruse
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: H
authors.initials: H
authors.lastname: Kiyoku
authors.forename: M
authors.initials: M
authors.lastname: Hiroi
authors.forename: T
authors.initials: T
authors.lastname: Shuin
authors.forename: H
authors.initials: H
authors.lastname: Enzan
mesh_terms: D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007606:Juxtaglomerular Apparatus / Q000378:metabolism / Q000473:pathology*; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000473:pathology