title: Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy.
abstract: The authors enrolled 1,029 patients with CD4 counts </= 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.
authors.affiliation: Institute of Infectious and Tropical Diseases, University of Milan, Italy. a-darm1@mailserver.unimi.it
authors.forename: A
authors.initials: A
authors.lastname: d'Arminio Monforte
authors.forename: P G
authors.initials: PG
authors.lastname: Duca
authors.forename: L
authors.initials: L
authors.lastname: Vago
authors.forename: M P
authors.initials: MP
authors.lastname: Grassi
authors.forename: M
authors.initials: M
authors.lastname: Moroni
mesh_terms: D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D019380:Anti-HIV Agents