CD8+ T-cell-mediated response to Listeria monocytogenes taken up in the liver and replicating within hepatocytes.
Like most other organisms that enter the bloodstream, the bulk of Listeria monocytogenes injected i.v. into mice is taken up by the liver. Listeriae not killed rapidly by infiltrating neutrophils are internalized by hepatocytes which constitute the principal site of intracellular replication in the liver. CD8+ T cells play a critical role in eliminating infected hepatocytes and resolving listerial infections of the liver; the specific mechanisms involved are not understood fully. Here, we review recent data implicating the cytolytic activities expressed by MHC class Ia- and class Ib-restricted CD8+ T cells in host resistance to Listeria. Evidence demonstrating the perforin- and/or Fas ligand-dependent induction of caspase activity and the resultant apoptosis of Listeria-infected hepatocytes is discussed.
Gregory
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Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA. sgregory@lifespan.org
Liu
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D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D017209:Apoptosis; D001427:Bacterial Toxins; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D020169:Caspases / Q000502:physiology; D004789:Enzyme Activation; D053222:Fas Ligand Protein; D006183:H-2 Antigens / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology; D006460:Hemolysin Proteins; D008089:Listeria monocytogenes / Q000254:growth & development / Q000276:immunology*; D008088:Listeriosis / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D008222:Lymphokines / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000502:physiology; D051379:Mice; D018448:Models, Immunological; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D019014:fas Receptor / Q000502:physiology
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D006183:H-2 Antigens; D006360:Heat-Shock Proteins; D006460:Hemolysin Proteins; D008222:Lymphokines; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D019014:fas Receptor; D054353:Perforin; D020169:Caspases; C038705:hlyA protein, Listeria monocytogenes