Mapping of the beige (bg) gene on rat chromosome 17.
The rat beige (bg) autosomal recessive gene, causing Chediak-Higashi Syndrome (CHS) in rat, was mapped on Chr 17 by using synteny of rat to mouse and humans. The linkage between the beige gene and PCR-amplified microsatellite markers in (DA-bg x BN)F1 x DA-bg backcross progeny was analysed. The recombination frequency was 9.5% between Prl and Acrm and 19.1% between Acrm and bg. The proposed order of three genes is Prl-Acrm-bg. This rat bg gene was confirmed to be homologus to the beige (bg) gene of mouse located on Chr 13 and the CHS (Lyst) gene of man located on Chr 1 (1q43).
Nishikawa
T
T
Institute for Experimental Animals, Hamamatsu University School of Medicine, Shizuoka, Japan.
Nishimura
M
M
D000818:Animals; D002609:Chediak-Higashi Syndrome / Q000235:genetics; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D008040:Genetic Linkage; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D018895:Microsatellite Repeats / Q000235:genetics; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics*; D051381:Rats; D033921:Vesicular Transport Proteins
D047908:Intracellular Signaling Peptides and Proteins; C102161:LYST protein, human; C491133:Lyst protein, mouse; C491134:Lyst protein, rat; D011506:Proteins; D033921:Vesicular Transport Proteins