Cortical development: Cdk5 gets into sticky situations.
Cyclin-dependent kinase 5 (Cdk5) is much more than its name implies; it plays a role in neuronal migration, neurite outgrowth and degeneration. Recent evidence suggests that Cdk5 regulates neuronal adhesion and cytoskeletal dynamics.
Homayouni
R
R
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, 38105, USA.
Curran
T
T
D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002448:Cell Adhesion; D002540:Cerebral Cortex / Q000166:cytology*; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D015534:Trans-Activators; D051176:beta Catenin
C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D015534:Trans-Activators; D051176:beta Catenin; C089495:neuronal Cdk5 activator (p25-p35); D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human; D018844:Cyclin-Dependent Kinases