Comparative study of bioartificial liver support and plasma exchange for treatment of pigs with fulminant hepatic failure.
Recently, bioartificial liver (BAL) treatment was reported to provide beneficial effects for patients with fulminant hepatic failure (FHF). Some success in experimental or clinical trials has been reported; however, the evaluation of BAL efficacy remains unclear, especially in comparison with other treatments for FHF. The purpose of this study was to compare the efficacy between BAL and plasma exchange (PE) in experimentally induced FHF in pigs. Pigs undergoing hepatic devascularization (HD) were placed into the following groups: no treatment (control; n = 6), BAL treatment (BAL; n = 5), and plasma exchange (PE; n = 5). Each treatment was initiated 6 h after HD and lasted for 4 h. BAL treatment significantly improved liver functions in FHF pigs. The decrease in cerebral perfusion pressure was also significantly suppressed in the pigs with BAL, and their survival time was prolonged compared with the results in pigs with PE. The effects of BAL outperform those of PE in the treatment of experimental FHF model.
Kamohara
Y
Y
Department of Surgery II, Nagasaki University School of Medicine, Nagasaki, Japan.
Fujioka
H
H
Eguchi
S
S
Kawashita
Y
Y
Furui
J
J
Kanematsu
T
T
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002469:Cell Separation; D002560:Cerebrovascular Circulation / Q000502:physiology; D004195:Disease Models, Animal; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D007427:Intracranial Pressure / Q000502:physiology; D008099:Liver / Q000166:cytology; D017093:Liver Failure / Q000628:therapy*; D019164:Liver, Artificial; D008567:Membranes, Artificial; D010951:Plasma Exchange; D020959:Polyethylene; D013055:Spectrophotometry, Infrared; D015996:Survival Rate; D013552:Swine
D008567:Membranes, Artificial; D020959:Polyethylene