title: [Mycotoxins as exposure parameters in bioaerosols of composting sites].
abstract: The potential to produce mycotoxins was investigated for freshly isolated strains of airborne fungi. The spectra of metabolites in conidial extracts and culture extracts were compared for some relevant species. Furthermore, their potential to produce mycotoxins on semi-natural media (compost extract agar) supplemented with sucrose, yeast extract, and carboxymethylcellulose in different combinations was investigated. In native bioaerosols in a compost facility (plant 2), tryptoquivaline, a compound with tremorgenic properties, and trypacidin, for which no toxic properties are described, were found. The highly toxic metabolites gliotoxin and verruculogen were not found in the bioaerosols, although they were produced by some strains in pure culture. An inventory of microbial metabolites in addition of fungal propagules has led to a more detailed identification of potential health hazards at the working place. In addition to the pathogenic and allergological relevance, airborne fungi are thus of toxicological concern.
authors.affiliation: Institut für Hygiene und Umweltmedizin, Universitätsklinikum der RWTH Aachen.
authors.forename: G
authors.initials: G
authors.lastname: Fischer
authors.forename: T
authors.initials: T
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Ostrowski
authors.forename: R
authors.initials: R
authors.lastname: Schwalbe
authors.forename: W
authors.initials: W
authors.lastname: Dott
mesh_terms: D000336:Aerosols; D000391:Air Microbiology; D000395:Air Pollutants, Occupational / Q000032:analysis*; D005858:Germany; D006801:Humans; D009183:Mycotoxins / Q000032:analysis*; D012037:Refuse Disposal
chemical_list: D000336:Aerosols; D000395:Air Pollutants, Occupational; D009183:Mycotoxins