title: Odorant inhalation affects skin barrier homeostasis in mice and humans.
abstract: Previous studies have suggested that psychological stress delays cutaneous barrier recovery following acute barrier disruption, and that sedative drugs block this delay. A sedative effect of some odorants has been reported. In the present study, we demonstrate that odorant inhalation affects cutaneous barrier homeostasis in both mice and humans. Odorants with a sedative effect prevented the delay of skin barrier recovery induced by stress after acute barrier disruption. Other odorants did not show this effect.
authors.affiliation: Shiseido Research Center 2, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan. mitsuhiro.denda@to.shiseido.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Denda
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: K
authors.initials: K
authors.lastname: Shoji
authors.forename: M
authors.initials: M
authors.lastname: Tanida
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D004780:Environment, Controlled; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009822:Oils, Volatile / Q000494:pharmacology*; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D012881:Skin Temperature / Q000187:drug effects; D013315:Stress, Psychological / Q000209:etiology
chemical_list: D001555:Benzene Derivatives; D006993:Hypnotics and Sedatives; D009822:Oils, Volatile