title: Multiple myeloma presenting high fever and high serum levels of lactic dehydrogenase, CRP, and interleukin-6.
abstract: Two myeloma patients presented high fever with no signs or data indicating infection at diagnosis or relapse. Both patients had plasmablastic myeloma, and serum levels of lactic dehydrogenase (LDH) and CRP were extremely high. Plasmablastic morphology, high LDH, and CRP were recognized as poor prognostic factors, indicating a fulminant phase of multiple myeloma. Interleukin-6 (IL-6) was only high in measured cytokines. We proposed that IL-6 caused high fever and induced the fulminant phase in these 2 cases.
authors.affiliation: School of Health Sciences, Faculty of Medicine, Gunma University, Maebashi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: S
authors.initials: S
authors.lastname: Takada
authors.forename: N
authors.initials: N
authors.lastname: Hatsumi
authors.forename: A
authors.initials: A
authors.lastname: Yokohama
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Uchiumi
authors.forename: T
authors.initials: T
authors.lastname: Maehara
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
authors.forename: N
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: K
authors.initials: K
authors.lastname: Morita
authors.forename: J
authors.initials: J
authors.lastname: Tamura
authors.forename: M
authors.initials: M
authors.lastname: Sawamura
authors.forename: M
authors.initials: M
authors.lastname: Karasawa
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D005334:Fever; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000503:physiopathology*
chemical_list: D015850:Interleukin-6; D002097:C-Reactive Protein; D007770:L-Lactate Dehydrogenase