Identification of an oxidation product of aminoethylcysteine ketimine dimer.
In continuation of our previous work dedicated to the detection of the oxidation products of aminoethylcysteine ketimine dimer by oxygen reactive species, we give here data for the identification of the alpha, beta unsaturated sulfoxide as the main product of interaction of the dimer with H2O2. Identification has been done on the basis of mass spectrometry and NMR analyses of the product isolated by preparative chromatography.
Pecci
L
L
Dipartimento di Scienze Biochimiche A. Rossi Fanelli and Centro di Biologia Molecolare del CNR, Università di Roma La Sapienza, Italy.
Antonucci
A
A
Pinnen
F
F
Cavallini
D
D
D000603:Amino Acids, Sulfur / Q000097:blood / Q000737:chemistry* / Q000302:isolation & purification / Q000652:urine; D000818:Animals; D002417:Cattle; D002845:Chromatography; D002851:Chromatography, High Pressure Liquid; D019281:Dimerization; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D017382:Reactive Oxygen Species / Q000378:metabolism
D000603:Amino Acids, Sulfur; D017382:Reactive Oxygen Species; C035497:thialysine ketimine; D006861:Hydrogen Peroxide