title: Diastereoselectivity in Mn(III)-promoted 4-exo-trig cyclization of enamides to beta-lactams
abstract: [reaction: see text] The effect of chiral substituents on the enamide nitrogen atom upon the diastereoselection of the Mn(III)-mediated 4-exo-trig cyclization to beta-lactams was studied. A significant level of diastereoselectivity was achieved when an amino acid ester moiety was included into the enamidic skeleton. The structure of the major diastereoisomer was suggested by semiempirical calculations.
authors.affiliation: Centro CNR C.S.C.S.O.N., Dipartimento di Chimica, Universita degli Studi La Sapienza, Roma, Italy. dannibale@axrma.uniroma1.it
authors.initials: A
authors.lastname: D'Annibale
authors.initials: D
authors.lastname: Nanni
authors.initials: C
authors.lastname: Trogolo
authors.initials: F
authors.lastname: Umani