Mitochondrial control of cell death.
In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise. This has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
Kroemer
G
G
Centre National de la Recherche Scientifique, CNRS-ULR1599, Institut Gustave Roussy 24 rue Calmette Desmoulins, F-94805 Villejuif. kroemer@infobiogen.fr
Reed
J C
JC
D017209:Apoptosis / Q000502:physiology*; D004194:Disease; D007425:Intracellular Membranes / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D010539:Permeability