Schizophrenia with onset after age 50 years. I: Phenomenology and risk factors.
BACKGROUND
Schizophrenia occurring for the first time in late life may be a distinct entity or part of a continuum.


OBJECTIVE
Can late-onset schizophrenia (LOS) and early-onset schizophrenia (EOS) be differentiated by their phenomenology and risk factors to their development?


METHODS
Convenience samples of 27 DSM-III-R defined LOS subjects, 30 EOS subjects and 34 control subjects were systematically assessed.


RESULTS
Premorbidly, both groups of subjects with schizophrenia had personality traits that were different from controls but not from each other. The EOS subjects had more family members with a history of psychiatric illness or schizophrenia and less hearing impairment than the other two groups, which did not differ from each other. Clinically, LOS and EOS subjects were similar, except that EOS subjects had more negative symptom scores, tended to have more delusions of guilt/sin and of being controlled and more formal thought disorder, and had significantly poorer instrumental activities of daily living.


CONCLUSIONS
Phenomenology and risk factors do not distinguish discrete LOS.
Brodaty
H
H
School of Psychiatry, University of New South Wales, Sydney. h.brodaty@unsw.edu.au
Sachdev
P
P
Rose
N
N
Rylands
K
K
Prenter
L
L
D017668:Age of Onset; D000368:Aged; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006311:Hearing Disorders / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D012923:Social Class; D012934:Social Isolation; D018709:Statistics, Nonparametric
D014150:Antipsychotic Agents