title: CTG triplet repeat expansion in a laryngeal carcinoma from a patient with myotonic dystrophy.
abstract: A 66-year-old Japanese man with myotonic dystrophy (DM) underwent total laryngectomy for laryngeal carcinoma. The size of the expanded DNA fragment (EF) from the leukocytes and normal laryngeal tissues of this patient was only slightly longer than that in normal subjects. EF, however, was markedly longer in the laryngeal carcinoma. These findings support the hypothesis that elongation of the CTG repeat in the DM kinase gene occurs during acquired cell proliferation.
authors.affiliation: Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, Japan. oryuichi@saitama-med.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Osanai
authors.forename: M
authors.initials: M
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Hirose
authors.forename: T
authors.initials: T
authors.lastname: Homma
authors.forename: I
authors.initials: I
authors.lastname: Kawabata
mesh_terms: D000368:Aged; D002455:Cell Division; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000235:genetics* / Q000601:surgery; D007962:Leukocytes / Q000737:chemistry; D008297:Male; D009223:Myotonic Dystrophy / Q000150:complications* / Q000235:genetics*; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D019680:Trinucleotide Repeat Expansion
chemical_list: C585517:DMPK protein, human; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases