Altered expression of members of the IGF-axis in hepatoblastomas.
Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development.
Gray
S G
SG
Dept. of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Eriksson
T
T
Ekström
C
C
Holm
S
S
von Schweinitz
D
D
Kogner
P
P
Sandstedt
B
B
Pietsch
T
T
Ekström
T J
TJ
D016147:Genes, Tumor Suppressor; D018197:Hepatoblastoma / Q000235:genetics*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics*; D009124:Muscle Proteins / Q000235:genetics; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated; D017451:Receptors, Somatomedin / Q000235:genetics; D013002:Somatomedins / Q000235:genetics*
C094335:H19 long non-coding RNA; D018969:Insulin-Like Growth Factor Binding Proteins; D009124:Muscle Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated; D017451:Receptors, Somatomedin; D013002:Somatomedins