Disseminated lupus vulgaris and papulonecrotic tuberculid: case report.
The incidence of tuberculosis and extrapulmonary forms of this disease is increasing all over the world. Lupus vulgaris is the most prevalent form of cutaneous tuberculosis in Europe and the Middle East. Papulonecrotic tuberculid, the most common form of hyperergic response to mycobacteria or their fragments, is uncommon in children. We report lupus vulgaris with papulonecrotic tuberculid in a 12-year-old girl who had a 3-year history of slowly growing plaques on her trunk, extremities, and the tip of her nose and papuloulcerative lesions over her entire body. A skin biopsy specimen showed minimally caseating granulomatous inflammation. Staining for acid-fast bacilli was negative in both plaques and papules. Polymerase chain reaction identified Mycobacterium tuberculosis DNA in the patient's sputum, gastric fluid, and plaques and was negative in the papules. She was started on antituberculous therapy with four drugs and her lesions responded rapidly.
Senol
M
M
Department of Dermatology, Inönü University School of Medicine, Malatya, Turkey. msenol@aidata.com.tr
Ozcan
A
A
Aydin
A
A
Karincaoglu
Y
Y
Sasmaz
S
S
Sener
S
S
D000995:Antitubercular Agents / Q000008:administration & dosage; D001707:Biopsy, Needle; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008177:Lupus Vulgaris / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification*; D009336:Necrosis; D014421:Turkey
D000995:Antitubercular Agents