Regulation of cell cycle re-entry by growth, survival and stress signalling pathways.
The mitogen-activated and stress-activated protein kinases transduce signals from plasma membrane signalling machinery into the nucleus to modulate gene expression. By regulating the genomic response to environmental cues (growth factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological responses.
Cook
S J
SJ
Inositide Laboratory, Signalling Programme, The Babraham Institute, Cambridge, UK.
Balmanno
K
K
Garner
A
A
Millar
T
T
Taverner
C
C
Todd
D
D
D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D002455:Cell Division; D002470:Cell Survival; D016922:Cellular Senescence; D019938:Cyclin D1 / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D019938:Cyclin D1; D019869:Phosphatidylinositol 3-Kinases; D018844:Cyclin-Dependent Kinases; D018631:ras Proteins