Understanding the Doppler RI: impact of renal arterial distensibility on the RI in a hydronephrotic ex vivo rabbit kidney model.
The aim of this study was to evaluate the influence of elevated ureteral pressure on renal arterial distention, and thereby on the Doppler resistive index. Seven isolated rabbit kidneys were subjected to a pulsatile perfusion while the renal pelvis was pressurized via the ureter. Renal vascular pressure, flow, resistance (pressure/flow) and conductance (flow/pressure) were compared to simultaneous resistive index measurements using linear regression analysis. Changes in the Conductance Index (systolic conductance - diastolic conductance/systolic conductance) were likewise compared to the resistive index. Elevations in ureteral pressure were significantly correlated with (1) increased resistive index values, (2) increased mean renal vascular resistance, (3) decreased mean conductance, and (4) increased conductance index values (for all correlations P < 0.05). The increases in the resistive index correlated significantly with increases in the conductance index. This study shows that elevated ureteral pressure, likely acting via interstitial pressure, diminishes the conductance of the renal vascular bed. Because this effect is more dramatic at diastole, the cyclic patterns of flow are altered, resulting in elevated resistive index values. The results indicate the importance of the interaction between vascular distensibility and pulsatile flow, rather than overall mean renal vascular resistance, in determining resistive index values.
Murphy
M E
ME
Department of Pharmacology and Neuroscience, The Albany Medical Center, New York, USA.
Tublin
M E
ME
D000818:Animals; D001783:Blood Flow Velocity; D004195:Disease Models, Animal; D006869:Hydronephrosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D010477:Perfusion; D011312:Pressure; D011673:Pulsatile Flow; D011817:Rabbits; D012077:Renal Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012079:Renal Circulation; D018615:Ultrasonography, Doppler, Color; D014513:Ureter / Q000000981:diagnostic imaging / Q000503:physiopathology; D014655:Vascular Resistance