[Fertility preservation by ovarian tissue cryopreservation].
Female fertility may be compromised after radio or chemotherapy for malignant as well as non-malignant diseases. It could be saved by cryopreservation of ovarian tissue, since it is now well established that primordial follicles can survive freezing. Many births have been obtained in rodents with thawed ovarian fragments, after grafting or in vitro folliculogenesis. Both techniques are more difficult in large animal species, and need further development to enter clinical practice. However, storing ovarian samples is already indicated, especially in younger patients who will require restoration of their fertility in a far future.
Zorn
J R
JR
Service de Gynécologie-Obstétrique III, Clinique Universitaire Baudelocque, Hôpital Cochin, 123 Bd de Port-Royal, 75014 Paris, France. jean-rene@cch.ap-hop-paris.fr
Guibert
J
J
D000818:Animals; D015925:Cryopreservation; D005260:Female; D005298:Fertility; D005831:Genital Diseases, Female / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D007247:Infertility, Female / Q000201:enzymology* / Q000209:etiology*; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary / Q000502:physiology* / Q000637:transplantation; D011247:Pregnancy; D014182:Transplantation, Autologous