title: Ridge filter design and optimization for the broad-beam three-dimensional irradiation system for heavy-ion radiotherapy.
abstract: The broad-beam three-dimensional irradiation system under development at National Institute of Radiological Sciences (NIRS) requires a small ridge filter to spread the initially monoenergetic heavy-ion beam to a small spread-out Bragg peak (SOBP). A large SOBP covering the target volume is then achieved by a superposition of differently weighted and displaced small SOBPs. Two approaches were studied for the definition of a suitable ridge filter and experimental verifications were performed. Both approaches show a good agreement between the calculated and measured dose and lead to a good homogeneity of the biological dose in the target. However, the ridge filter design that produces a Gaussian-shaped spectrum of the particle ranges was found to be more robust to small errors and uncertainties in the beam application. Furthermore, an optimization procedure for two fields was applied to compensate for the missing dose from the fragmentation tail for the case of a simple-geometry target. The optimized biological dose distributions show that a very good homogeneity is achievable in the target.
authors.affiliation: Therapeutic Beam Assessment Office, Research Center of Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: B
authors.initials: B
authors.lastname: Schaffner
authors.forename: T
authors.initials: T
authors.lastname: Kanai
authors.forename: Y
authors.initials: Y
authors.lastname: Futami
authors.forename: M
authors.initials: M
authors.lastname: Shimbo
authors.forename: E
authors.initials: E
authors.lastname: Urakabe
mesh_terms: D002460:Cell Line; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D063193:Heavy Ion Radiotherapy; D006801:Humans; D015233:Models, Statistical; D016011:Normal Distribution; D011878:Radiotherapy / Q000295:instrumentation* / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D012062:Relative Biological Effectiveness; D012469:Salivary Glands / Q000528:radiation effects
chemical_list: D003037:Cobalt Radioisotopes