Novel one-step synthesis of thiazolo[3,2-b]1,2,4-triazoles.
[reaction: see text] Reactions of chalcones 3a-f with bis(1H-1,2,4-triazolyl) sulfoxide 4 formed the thiazolo[3,2-b]1,2,4-triazoles 5a-f, which resemble closely some previously prepared COX-2 inhibitors. The structure of 5a was confirmed by X-ray analysis.
Katritzky
A R
AR
Department of Chemistry, Center for Heterocyclic Compounds, University of Florida, Gainesville 32611-7200, USA. katritzky@chem.ufl.edu
Pastor
A
A
Voronkov
M
M
Steel
P J
PJ
D018360:Crystallography, X-Ray; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D014230:Triazoles