Autism--an evolving concept.
BACKGROUND
The rapid increase in research endeavour has not kept pace with the advent of well-publicized theories and treatments for autism.


OBJECTIVE
To explore some of the newer developments in biological research into autism.


METHODS
A review of recent publications and presentations.


RESULTS
The concept is shifting from the narrow perception of aloof autism, described by Kanner, to a wider one that includes a spectrum extending to a broader, subclinical phenotype. The genetic basis has been established; now we need to discover the location and interaction of the relevant sites. There is considerable interest in the bowel as a pathogenetic agent, particularly in the effects of exogenous opioids and multiple viral infection (the latter posing a public health problem). Also of concern is the role of (potentially treatable) epilepsy, analogous to the Laudau-Kleffner syndrome.


CONCLUSIONS
In the absence of a cure, the implementation of ideas will continue to outstrip factual evidence. Clinicians are challenged by the availability of information (and misinformation), particularly on the internet.
Berney
T P
TP
Northgate and Prudhoe NHS Trust, Prudhoe Hospital, Northumberland.
D001321:Autistic Disorder / Q000175:diagnosis* / Q000209:etiology*; D015897:Comorbidity; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000175:diagnosis; D006801:Humans; D012559:Schizophrenia / Q000175:diagnosis