Absolute configuration of scyphostatin
[reaction: see text] The absolute configuration of the side chain of scyphostatin (1) has been established. The chemical degradation of 1 gave 4 and 9, which correspond to the C7'-C12' and C13'-C16' fragments of the natural products, respectively. The spectroscopic data and [alpha]D values of both compounds were compared to those of authentic samples. The results show that the absolute configuration of 1 is 8'R,10'S,14'R.
Saito
S
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
Tanaka
N
Fujimoto
K
Kogen
H