title: Self-adhesive silicone gel sheet: a treatment for hypertrophic scars and keloids.
abstract: An open clinical trial was conducted to assess the effect of self-adhesive silicone gel sheet (SASGS) for the treatment of hypertrophic scars and keloids in Thai people. Patients were instructed to apply the SASGS to the scars as long as possible, but not less than 12 hours per day for at least 8 weeks. The subjective results of the treatment were evaluated by the patients. The scars were evaluated for color, height, weight before and after treatment at 4 and 8 weeks. Eighteen patients with 18 hypertrophic scars or keloids were recruited into the study. Their ages ranged from 6 to 33 years (mean 21 years). The average duration of the scars was 5.7 years. Twelve patients (66.67%) stated good results. All of the 18 patients wanted to continue the treatment with SASGS. Heights of the scars were reduced in 12 lesions (66.67%) after treatment for 8 weeks (P = 0.058). Weights of the lesions were decreased in 10 lesions (55.55%) but were not statistically different (P = 0.090). Seven lesions (36.84%) were improved in color. Two patients (11.11%) developed erythematous rash around the lesions which subsided after withdrawal of the treatment. The long term follow-up for the recurrence and the mechanism of action of this treatment should be studied further.
authors.affiliation: Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Chuangsuwanich
authors.forename: V
authors.initials: V
authors.lastname: Osathalert
authors.forename: S
authors.initials: S
authors.lastname: Muangsombut
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D002648:Child; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007627:Keloid / Q000188:drug therapy / Q000473:pathology; D008297:Male; D011446:Prospective Studies; D020034:Silicone Gels / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D020034:Silicone Gels