Effect of azithromycin plus rifampin versus amoxicillin alone on eradication and inflammation in the chronic course of Chlamydia pneumoniae pneumonitis in mice.
The effects of treatment with azithromycin plus rifampin (A+R), amoxicillin (A), or placebo (P) on the chronic course of experimental Chlamydia pneumoniae pneumonitis in mice were assessed by culture, PCR, and immunocytochemistry as well as by degree of inflammation in lung tissue. Eradication of the pathogen was significantly more frequent and inflammation in tissue was significantly reduced after treatment with A+R compared to after treatment with A or P. Combination therapy with azithromycin plus rifampin showed favorable effects in the chronic course of C. pneumoniae pneumonitis.
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Department of Clinical Research, Inselspital, University of Bern, Bern, Switzerland.
Wolf
K
K
Schaffner
T
T
Malinverni
R
R
D000658:Amoxicillin / Q000008:administration & dosage*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017963:Azithromycin / Q000008:administration & dosage*; D002690:Chlamydia Infections / Q000188:drug therapy*; D016993:Chlamydophila pneumoniae / Q000187:drug effects*; D004359:Drug Therapy, Combination; D051379:Mice; D011014:Pneumonia / Q000188:drug therapy*; D012293:Rifampin / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D017963:Azithromycin; D012293:Rifampin