[Nephrologic emergency or bland course? Why glomerulonephritis should be checked out].
Glomerulonephritis frequently takes an asymptomatic course, and may lead on to chronic renal insufficiency. If clinical signs of glomerulonephritis are present, the syndrome must be characterized by means of a comprehensive diagnostic work-up. The definitive diagnosis can be established only on the basis of a renal biopsy, which also permits an assessment of the prognosis. In this review, the basic pathogenetic principles are described in brief. Taking the most important forms of glomerulonephritis--IgA nephropathy, membranous glomerulonephritis and rapidly progressive glomerulonephritis--as examples, the general therapeutic options and a number of specific treatment strategies are discussed. New facts relating to the mechanisms of glomerular damage will in future make possible the use of targeted therapeutic interventions.
Dendorfer
U
U
Med. Univ.-Poliklinik München. dendorfer@medpoli.med.uni-muenchen.de
D001706:Biopsy; D003937:Diagnosis, Differential; D004630:Emergencies; D005921:Glomerulonephritis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology