title: [Noncultivatable forms of Francisella tularensis].
abstract: Conditions for the appearance of F. tularensis uncultivated forms and for their reversion into the initial state have been studied. As revealed in this study, the combined influence of stress factors (starvation and low temperature) may result in the transition of F. tularensis into the uncultivated state in which it persists in the environment during the period between epidemics. The reversion of F. tularensis uncultivated forms into the initial state has been carried out with the use of sensitive animals. The uncultivated state of F. tularensis should be regarded as the actual form of the existence of the causative agent of tularemia in soil and water ecosystems.
authors.affiliation: Research Institute for Plague Control, Rostov-on-Don, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Romanova
authors.forename: B N
authors.initials: BN
authors.lastname: Mishan'kin
authors.forename: N L
authors.initials: NL
authors.lastname: Pichurina
authors.forename: S O
authors.initials: SO
authors.lastname: Vodop'ianov
authors.forename: S R
authors.initials: SR
authors.lastname: Saiamov
mesh_terms: D002250:Carbon Radioisotopes; D002876:Chromosomes, Bacterial / Q000235:genetics; D003470:Culture Media; D017931:DNA Primers; D004269:DNA, Bacterial / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005604:Francisella tularensis / Q000235:genetics / Q000254:growth & development* / Q000648:ultrastructure; D008854:Microscopy, Electron; D016133:Polymerase Chain Reaction / Q000379:methods; D013696:Temperature
chemical_list: D002250:Carbon Radioisotopes; D003470:Culture Media; D017931:DNA Primers; D004269:DNA, Bacterial