Reduced interleukin-1 responsiveness in immune system and central nervous system of inbred polydipsic (STR/N) mice.
Inbred polydipsic mice (STR/N strain) have primary polydipsia. The previous studies found abnormalities in the central nervous system (CNS), especially in the hypothalamus and circumventricular organ. As a part of pursuing to find the cause of the polydipsia, we investigated immunological characteristics of STR/N mice, using the ICR strain of mice as control. Their thymic subset cells showed that CD4+CD8+ double positive cells were increased, CD4+ single positive cells were decreased and CD5 expression was deficient, compared to ICR mice. T cell proliferative response and interleukin (IL)-2 production caused by IL-1beta stimulation were reduced in STR/N mice than those in the ICR mice. In in vivo studies the degree of thymic atrophy and the increases in serum level of ACTH and corticosterone induced by intraperitoneal IL-1beta injection were much less in STR/N mice than those in controls. Furthermore, adipsic response also induced by IL-1beta injection was greatly reduced compared to their control mice. All these results suggest that the responsiveness to IL-1 is impaired both in the immune system and the CNS of STR/N mice.
Okada
K
K
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
Yoshida
Y
Y
Sugiura
T
T
Tanaka
H
H
Tsuji
S
S
Yamashita
H
H
Yamashita
U
U
D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000187:drug effects*; D018956:CD5 Antigens / Q000032:analysis / Q000502:physiology; D003345:Corticosterone / Q000097:blood; D004327:Drinking Behavior; D007107:Immune System / Q000187:drug effects*; D007375:Interleukin-1 / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D016131:Lymphocyte Subsets / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D013950:Thymus Gland / Q000187:drug effects
D018956:CD5 Antigens; D007375:Interleukin-1; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone