Twenty-four hours of insulin infusion does not lower plasma lipoprotein(a) in healthy men.
The effect of 24-h exogenous hyperinsulinaemia on the plasma level of the atherogenic lipoprotein(a) (Lp(a)) is unknown. We evaluated the responses of plasma cholesterol, triglycerides, apolipoprotein (apo) B and Lp(a) during 24-h insulin infusion (180 pmol/kg/h) in 6 healthy men. Plasma total cholesterol (p < 0.01) and triglycerides (p < 0.05) decreased after 24 h of hyperinsulinaemia. Apo B was unchanged after 8 h (-2.4 +/- 3.0%, n.s.) and decreased by 10.9 +/- 4.8% (p<0.025) after 24 h of insulin. In contrast, Lp(a) did not decrease (+28.4 +/- 18.4%, n.s., and +/- 49.1 +/- 22.0%, n.s., after 8 and 24 h of insulin, respectively). This experiment supports the hypothesis that moderate hyperinsulinaemia has a different effect on the plasma level of triglyceride-rich lipoproteins compared to Lp(a).
Riemens
S C
SC
Department of Endocrinology, University Hospital Groningen, The Netherlands.
Dullaart
R P
RP
D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D015243:Cholesterol, VLDL / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000139:chemically induced; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage*; D017270:Lipoprotein(a) / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001055:Apolipoproteins B; D015243:Cholesterol, VLDL; D007004:Hypoglycemic Agents; D007328:Insulin; D017270:Lipoprotein(a); D014280:Triglycerides