Intercellular adhesion molecule-1 gene polymorphisms in Behçet's disease.
Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behçet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease.
Verity
D H
DH
Guy's and St Thomas Hospitals, London, UK. dverity@rayne.umds.ac.uk
Vaughan
R W
RW
Kondeatis
E
E
Madanat
W
W
Zureikat
H
H
Fayyad
F
F
Marr
J E
JE
Kanawati
C A
CA
Wallace
G R
GR
Stanford
M R
MR
D001528:Behcet Syndrome / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics; D011110:Polymorphism, Genetic
D018799:Intercellular Adhesion Molecule-1