[Serotonin receptor knockout mice].
The neurotransmitter serotonin is known to play a key role in determining emotional state in higher animals, especially in humans. Pharmacological studies have highlighted a subset of serotonin receptor subtypes (1A, 2B and 2C) worthy of knockout analysis. Several groups investigated knockout phenotype and determined the physiological function of these receptors, although the phenotype of the mouse seems somewhat paradoxical. However, the results strongly suggest that serotonin receptors are mainly involved in emotion (i.e., anxiety, aggressive behavior, obesity and epilepsy).
Ishiura
S
S
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan.
D000818:Animals; D006801:Humans; D051379:Mice; D018345:Mice, Knockout / Q000502:physiology*; D011985:Receptors, Serotonin / Q000172:deficiency* / Q000502:physiology*
D011985:Receptors, Serotonin