title: Antibiotic susceptibility patterns of Neisseria meningitidis isolates from patients and asymptomatic carriers.
abstract: The activities of seven antimicrobial agents used for treatment and prophylaxis of meningococcal disease was investigated against 901 Neisseria meningitidis isolates, 112 of which were recovered from patients and 789 of which were recovered from asymptomatic carriers. The proportions of isolates with decreased susceptibility to penicillin were 55.3 and 39.0%, respectively. Penicillin- and ampicillin-intermediate strains were more common among serogroup C meningococci than among non-serogroup C meningococci from both patients and carriers.
authors.affiliation: Laboratorio de Referencia de Meningococos. Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Arreaza
authors.forename: L
authors.initials: L
authors.lastname: de La Fuente
authors.forename: J A
authors.initials: JA
authors.lastname: Vázquez
mesh_terms: D000667:Ampicillin / Q000494:pharmacology* / Q000627:therapeutic use; D002353:Carrier State; D006801:Humans; D008589:Meningococcal Infections / Q000188:drug therapy* / Q000378:metabolism*; D009345:Neisseria meningitidis / Q000187:drug effects*; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010406:Penicillins; D000667:Ampicillin