The synthesis of poly-4-thiouridylic acid and its effect on protein synthesis in a cell free system derived from rat liver.
The synthesis of poly-4-thiouridylic acid by thiolation of polycytidylic acid is described. A quantitative thiolation was achieved without any cleavage of the phosphodiester bond. The inhibitory effect of the poly-4-thiouridylic acid on protein synthesis in a cell free system derived from rat liver was investigated.
Hochberg
A A
AA
Keren-Zur
M
M
D000818:Animals; D002474:Cell-Free System; D008099:Liver / Q000737:chemistry; D010455:Peptides / Q000378:metabolism; D011066:Poly C / Q000737:chemistry; D011072:Poly U / Q000138:chemical synthesis* / Q000494:pharmacology; D011132:Polyribosomes / Q000187:drug effects* / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis* / Q000302:isolation & purification; D051381:Rats; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000494:pharmacology
D010455:Peptides; D011500:Protein Synthesis Inhibitors; D013873:Thionucleotides; C408286:poly-4-thiouridylic acid; D011072:Poly U; C012001:polyphenylalanine; D011066:Poly C