title: Apoptosis and p53 are associated with effect of preoperative radiation in oral squamous cell carcinomas.
abstract: This study was carried out to elucidate whether apoptosis and p53 can be used to stratify oral cancer patients into groups with a favorable or unfavorable response to preoperative radiation therapy. Thirty-two patients were evaluated. The apoptosis index was 1.7+/-0. 9% in the ineffective cases, and it was significantly lower than effective cases (3.2+/-1.2%). While 14 of 16 effective cases (86.7%) did not express p53, 13 of 16 ineffective cases (81.3%) overexpressed p53. These results suggest that mutated p53 in tumors is associated with a poor response to radiation which may be related to evasion of apoptosis in oral cancer.
authors.affiliation: Department of Oral and Maxillofacial surgery II, Okayama University Dental School, 2-5-1, Shikata, Okayama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Shintani
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: Y
authors.initials: Y
authors.lastname: Nakahara
authors.forename: N
authors.initials: N
authors.lastname: Terakado
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshihama
authors.forename: A
authors.initials: A
authors.lastname: Kiyota
authors.forename: Y
authors.initials: Y
authors.lastname: Ueyama
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000528:radiation effects*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000528:radiation effects*
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53