Antibiotic beads in the treatment of diabetic pedal osteomyelitis.
Antibiotic-impregnated polymethylmethacrylate (PMMA) beads have improved the outcome of osteomyelitis treatment in both experimental models and clinical trials. The primary benefit of antibiotic-impregnated PMMA beads is that they provide high local concentrations of antibiotic while systemic levels of antibiotic remain low. Little has been written about the specific use of antibiotic-impregnated PMMA beads in the treatment of diabetic pedal osteomyelitis. The authors review antibiotic-impregnated PMMA beads and provide examples of their use in the treatment of diabetic pedal osteomyelitis.
Roeder
B
B
Department of Surgery, Carl T. Hayden Vetrans' Affairs Medical Center, Phoenix, AZ 85012, USA.
Van Gils
C C
CC
Maling
S
S
D020341:Absorbable Implants; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D001843:Bone Cements / Q000737:chemistry; D003646:Debridement; D048909:Diabetes Complications; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005534:Foot Diseases / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000601:surgery; D019904:Polymethyl Methacrylate / Q000737:chemistry; D013203:Staphylococcal Infections / Q000188:drug therapy; D014031:Tobramycin / Q000008:administration & dosage; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D001843:Bone Cements; D004337:Drug Carriers; D014640:Vancomycin; D019904:Polymethyl Methacrylate; D014031:Tobramycin