Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy.
Helicobacter pylori is causally associated with gastritis and gastric cancer. Some developing countries with a high prevalence of infection have high gastric cancer rates, whereas in others, these rates are low. The progression of helicobacter-induced gastritis and gastric atrophy mediated by type 1 T-helper cells may be modulated by concurrent parasitic infection. Here, in mice with concurrent helminth infection, helicobacter-associated gastric atrophy was reduced considerably despite chronic inflammation and high helicobacter colonization. This correlated with a substantial reduction in mRNA for cytokines and chemokines associated with a gastric inflammatory response of type 1 T-helper cells. Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion.
Fox
J G
JG
Division of Comparative Medicine, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA. jgfox@mit.edu
Beck
P
P
Dangler
C A
CA
Whary
M T
MT
Wang
T C
TC
Shi
H N
HN
Nagler-Anderson
C
C
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000918:Antibody Specificity; D018925:Chemokines / Q000096:biosynthesis; D005260:Female; D005756:Gastritis / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology / Q000503:physiopathology; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D009351:Nematospiroides dubius / Q000276:immunology*; D017206:Strongylida Infections / Q000150:complications / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology
D000907:Antibodies, Bacterial; D018925:Chemokines; D007074:Immunoglobulin G; D007073:Immunoglobulin E