title: A synthetic hydroxy acid that shows tubular-shaped structure in solid-state and ionophoric activity in phospholipid bilayers
abstract: [formula: see text] In this contribution, we describe the ability of compound (+/-)-1b and six molecules of water to form in solid-state hexameric aggregates, which self-assemble to give hollow tubular structures. Single-crystal X-ray analysis shows that these tubes are open-ended, with irregular shape and internal van der Waals pore diameter between 6 and 9 A. In addition, transmembrane sodium transport activity was also assessed for (+/-)-1b using dynamic Na(+)-NMR technique.
authors.affiliation: Instituto de Bioorganica, CSIC, Tenerife, Spain.
authors.initials: C
authors.lastname: Perez
authors.initials: CG
authors.lastname: Espinola
authors.initials: C
authors.lastname: Foces-Foces
authors.initials: P
authors.lastname: Nunez-Coello
authors.initials: H
authors.lastname: Carrasco
authors.initials: JD
authors.lastname: Martin