title: Nasal nitric oxide is not altered by topical anesthesia.
abstract: This prospective study was undertaken to determine whether topical nasal anesthetic agents affect nasal nitric oxide (NO) output in healthy adults. Seven volunteers (aged: 29-56 (40.6 +/- 10.7) years, six male), were recruited. A topical anesthetic (4% lidocaine or 0.5% tetracaine) was sprayed into the subject's right nostril while the left nostril served as a control. Unilateral nasal NO and nasal volume were measured before administration of the anesthetic and at 15 and 30 minutes after the administration. The mean (+/- SD) unilateral nasal NO output was 307 +/- 45.9 nL/minute from the right nostril (exposure side) before the topical application of lidocaine. At 30 minutes after topical application (n = 6), it was 295.5 +/- 41.5 in the right nostril and 297.5 +/- 39.8 in the left (control side). In the tetracaine group (n = 7), the mean (+/- SD) unilateral nasal NO output was 302 +/- 53.3 before the administration and 307 +/- 39.7 at 30 minutes after the administration in the right nostril. The mean NO output in the left nostril at 30 minutes after the administration was 297.7 +/- 40.75. In neither group was there any significant difference in nasal NO output between either the pre- and postlocal anesthetic application on the exposure side (Group 1, P = 0.76; group 2, P = 0.41) or the two nostrils after topical anesthesia application (group 1, P = 0.83; group 2, P = 0.62). Topical anesthesia with either lidocaine or tetracaine does not alter nasal NO output. NO measurement should not be affected in circumstances that require topical anesthesia of the nasal cavity.
authors.affiliation: Zhenjiang First People's Hospital, Jiangsu, China.
authors.forename: W
authors.initials: W
authors.lastname: Qian
authors.forename: A
authors.initials: A
authors.lastname: Graciano
authors.forename: J S
authors.initials: JS
authors.lastname: Haight
authors.forename: P
authors.initials: P
authors.lastname: McClean
authors.forename: N
authors.initials: N
authors.lastname: Zamel
authors.forename: J S
authors.initials: JS
authors.lastname: Chapnik
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis*; D011446:Prospective Studies; D013748:Tetracaine / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D013748:Tetracaine; D009569:Nitric Oxide; D008012:Lidocaine