Dapsone hypersensitivity syndrome with coexisting acute hepatitis E.
A 14-year-old girl presented with fever, generalized lymphadenopathy, skin rash and hepatitis after starting dapsone. All abnormalities reversed with institution of prednisolone therapy after discontinuation of dapsone. The hepatic involvement was of hepatocellular type; it was associated with IgM anti-HEV antibodies, suggesting coexisting acute hepatitis E. We believe a causal link between the hepatotrophic viruses and dapsone hypersensitivity syndrome could exist.
Chogle
A
A
Kasturba Hospital for Infectious Diseases, Sane Guruji Marg, Mumbai.
Nagral
A
A
Soni
A
A
Agale
S
S
Jamadar
Z
Z
D000208:Acute Disease; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D016751:Hepatitis E / Q000150:complications*; D006801:Humans; D007917:Leprostatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007918:Leprosy / Q000150:complications / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome
D000893:Anti-Inflammatory Agents; D007917:Leprostatic Agents; D003622:Dapsone; D011239:Prednisolone