Total synthesis of Amaryllidaceae pyrrolophenanthridinium alkaloids via the Ziegler-Ullmann reaction: tortuosine, criasbetaine, and ungeremine.
Stark
L M
LM
Department of Medicinal Chemistry, Neurobiology Unit, Roche Bioscience, 3401 Hillview Avenue, Palo Alto, California 94304-1397, USA.
Lin
X F
XF
Flippin
L A
LA
D000470:Alkaloids / Q000138:chemical synthesis*; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007212:Indolizines; D010617:Phenanthridines / Q000138:chemical synthesis*; D010946:Plants, Medicinal / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007212:Indolizines; D010617:Phenanthridines; D011758:Pyrroles; C412025:criasbetaine; C412026:tortuosine; C016175:ungeremine