Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue.
The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4(+) T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4(+) lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.
Grivel
J C
JC
Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
Penn
M L
ML
Eckstein
D A
DA
Schramm
B
B
Speck
R F
RF
Abbey
N W
NW
Herndier
B
B
Margolis
L
L
Goldsmith
M A
MA
D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism* / Q000821:virology; D015497:HIV-1 / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008212:Lymphocyte Depletion; D008221:Lymphoid Tissue / Q000166:cytology; D019713:Receptors, CCR5 / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*
D019713:Receptors, CCR5; D019718:Receptors, CXCR4