title: Hormone replacement therapy in women with pre-existing hyperpigmented lesions.
abstract: OBJECTIVE
  This study was performed to determine whether skin pigmentation is darkened after hormone replacement therapy (HRT).
  
  
  METHODS
  The color of hyperpigmentary lesions and control sites before and after 1, 2, and 3 months of HRT was measured.
  
  
  RESULTS
  All of the three tested sites showed no significant pigment alteration in 3 months of follow up after starting HRT (P>0.05). Age, duration of menopause, and sex hormone levels did not correlate with pigmentation level.
  
  
  CONCLUSIONS
  Pigmentation changes after HRT are not significantly associated with the treatment. This finding suggests that low-dose estrogen replacement therapy does not induce pigmentation changes alone and that differences in individual susceptibility and end organ responsiveness or other multiple factors in addition to the sex hormone may be responsible for the development and darkening of hyperpigmentary lesions.
authors.affiliation: Department of Dermatology, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, South Korea.
authors.forename: S W
authors.initials: SW
authors.lastname: Choi
authors.forename: K Y
authors.initials: KY
authors.lastname: Roh
authors.forename: K W
authors.initials: KW
authors.lastname: Chung
authors.forename: M R
authors.initials: MR
authors.lastname: Kim
mesh_terms: D000328:Adult; D003124:Colorimetry; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced / Q000473:pathology*; D008875:Middle Aged; D012880:Skin Pigmentation / Q000187:drug effects*