title: Origin of YAP+ lineages of the human Y-chromosome.
abstract: We screened a total of 841 Y-chromosomes representing 36 human populations of wide geographical distribution for the presence of a Y-specific Alu insert (YAP+ chromosomes). The Alu element was found in 77 cases. We tested 5 biallelic and 8 polyallelic markers in 70 out of the 77 YAP+ chromosomes. We could identify the existence of a hierarchical and chronological structuring of ancestral and derived YAP+ lineages, giving rise to 4 haplogroups, 14 subhaplogroups and 60 haplotypes. Moreover, we propose a monophyletic origin for each one of the YAP+ lineages. Out-of-Africa and out-of-Asia models have been suggested to explain the origin and evolution of ancestral and derived YAP+ elements. We analyze the evidence supporting these two hypotheses, and we conclude that the information available does not allow one to decide between the out-of-Asia or out-of-Africa models.
authors.affiliation: Multidisciplinary Institute of Cell Biology (IMBICE), 1900 La Plata, Argentina.
authors.forename: C M
authors.initials: CM
authors.lastname: Bravi
authors.forename: G
authors.initials: G
authors.lastname: Bailliet
authors.forename: V L
authors.initials: VL
authors.lastname: Martinez-Marignac
authors.forename: N O
authors.initials: NO
authors.lastname: Bianchi
mesh_terms: D000349:Africa; D020087:Alu Elements / Q000235:genetics*; D000818:Animals; D001208:Asia; D005075:Biological Evolution; D005819:Genetic Markers; D005828:Genetics, Population; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D014998:Y Chromosome / Q000235:genetics*
chemical_list: D005819:Genetic Markers