title: Immunocytochemical analysis of the tumour suppressor protein (p53) in feline neoplasia.
abstract: Detectable p53 immunostaining in neoplasia generally correlates with the presence of a mutation in the coding region of the p53 gene and may provide insights into the pathogenic mechanisms underlying tumourigenesis. p53 immunoreactivity was examined in 77 feline tumours, selected as a representative sample of 486 specimens submitted for diagnosis and analyzed to estimate the relative frequencies of feline neoplasias. Immunocytochemical staining demonstrated nuclear immunopositivity in 46% of the squamous cell carcinomas (SCCs), 50% of the osteosarcomas, 33% of the mammary carcinomas, 16% of the adenocarcinomas and 14% of the haemangiosarcomas. In contrast, none of the malignant lymphomas or fibrosarcomas examined showed p53 immunoreactivity. These data support a role for p53 aberrations in the pathogenesis of certain feline tumours.
authors.affiliation: Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden Road, Glasgow, UK. l.nasir@udcf.gla.ac.uk
authors.forename: L
authors.initials: L
authors.lastname: Nasir
authors.forename: H
authors.initials: H
authors.lastname: Krasner
authors.forename: D J
authors.initials: DJ
authors.lastname: Argyle
authors.forename: A
authors.initials: A
authors.lastname: Williams
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000662:veterinary; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000662:veterinary; D002415:Cats; D006394:Hemangiosarcoma / Q000378:metabolism / Q000662:veterinary; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000378:metabolism; D009369:Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000662:veterinary*; D012516:Osteosarcoma / Q000378:metabolism / Q000662:veterinary; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis* / Q000502:physiology
chemical_list: D016159:Tumor Suppressor Protein p53