Nivalenol inhibits total and antigen-specific IgE production in mice.
Nivalenol (NIV) has been reported to induce hyperproduction of IgA, which is regulated by T-helper 2 cells (Th2); however, whether IgE production, which is under the regulation of Th2 cells, is induced by this compound remains largely unknown. We examined the effect of NIV on antigen-specific IgE production using ovalbumin (OVA)-specific T cell receptor alphabeta-transgenic mice. The mice produced significant amounts of total and antigen-specific IgE, IgG1, and IgA in serum when given OVA orally. Administration of NIV with OVA suppressed total IgE and OVA-specific IgE, IgG1, and IgA production significantly. Cytokine assay using splenocytes obtained from mice given the OVA plus NIV diet revealed that interleukin 4 (IL-4) production was suppressed and interleuin-2 (IL-2) production was enhanced. These results suggest that the inhibition of IL-4 production and enhancement of IL-2 production induced by NIV suppressed total and antigen-specific IgE production.
Choi
C Y
CY
Department of Biomedical Food Research, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Nakajima-Adachi
H
H
Kaminogawa
S
S
Sugita-Konishi
Y
Y
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D007073:Immunoglobulin E / Q000187:drug effects* / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D009183:Mycotoxins / Q000494:pharmacology*; D010047:Ovalbumin / Q000276:immunology; D018418:Th2 Cells; D014255:Trichothecenes / Q000494:pharmacology*
D007376:Interleukin-2; D009183:Mycotoxins; D014255:Trichothecenes; D015847:Interleukin-4; D007073:Immunoglobulin E; C038405:nivalenol; D010047:Ovalbumin