[Oligo(2'-O-tetrahydropyranylribonucleotides): hybridization properties and nuclease resistance].
Oligo(2'-tetrahydropyranylribonucleotides) and their analogues containing a 3'-3'-internucleotide bond at the 3'-terminus are nuclease-resistant and possess rather high affinity toward RNA, the main target in the antisense approach.
Kuznetsova
M A
MA
Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, Russia.
Pyshnyĭ
D V
DV
Repkova
M N
MN
Ven'iaminova
A G
AG
D000818:Animals; D020320:Oligoribonucleotides, Antisense / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*; D012260:Ribonucleases / Q000737:chemistry
D020320:Oligoribonucleotides, Antisense; D011714:Pyrans; D012260:Ribonucleases