title: Synthesis and chiroptical properties of Methanocycloocta
abstract: The synthesis of chiral methanocyclocta[b]indoles, the fused structures obtained from enantiomeric bicyclo[3.3.1]nonanones via Fisher indolization reaction, is reported. The starting optically active bicyclo[3.3.1]nonane-2,6-dione (1) was obtained by a chiral HPLC enantiomer separation on a swollen microcrystalline triacetylcellulose column and by the enzymatic resolution of the racemic dione. The circular dichroism (CD) spectra of the chiral structures 4, 5, and 7 were recorded, and the absolute configuration for the indole compounds was assigned. The theoretical calculations of the CD spectrum of diindole 4 reproduce the (1)B(b) couplet at 229 nm but predict wrong signs for the (1)L(a) and (1)L(b) bands using standard polarization directions. The CD spectrum of indole ketone 5 is reproduced correctly.
authors.affiliation: Department of Organic Chemistry, Vilnius University, 2734 Vilnius, Lithuania, and Organic Chemistry 1, Department of Chemistry, Lund University, P.O. Box 124, S-22100 Lund, Sweden.
authors.initials: E
authors.lastname: Butkus
authors.initials: U
authors.lastname: Berg
authors.initials: J
authors.lastname: Malinauskiene
authors.initials: J
authors.lastname: Sandstrom