Activities of taurolidine in vitro and in experimental enterococcal endocarditis.
In vitro, the antimicrobial agent taurolidine inhibited virtually all of the bacteria tested, including vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and Stenotrophomonas maltophilia, at concentrations between 250 and 2,000 microg/ml. Taurolidine was not effective in experimental endocarditis. While it appears unlikely that this antimicrobial would be useful for systemic therapy, its bactericidal activity and the resistance rates found (<10(-9)) are favorable indicators for its possible development for topical use.
Torres-Viera
C
C
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.
Thauvin-Eliopoulos
C
C
Souli
M
M
DeGirolami
P
P
Farris
M G
MG
Wennersten
C B
CB
Sofia
R D
RD
Eliopoulos
G M
GM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects*; D020615:Stenotrophomonas maltophilia / Q000187:drug effects*; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013829:Thiadiazines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010406:Penicillins; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine; D010068:Oxacillin