RBE-LET relationships in mutagenesis by ionizing radiation.
The paper considers the relationship between the quality of radiation and biological lesions produced by ionizing radiation. The paper provides a brief review of the modelling of induction of strand breakage, chromosome aberration, revertant mutation in bacteria and Drosophila melanogaster. Experimental data are presented for the relative biological effectiveness of helium ions and alpha-particles for mutation induction and genome lethality in Escherichia coli. The paper examines the relationship between the mutational events and LET. The RBE-LET values for T4 phage, E. coli WP2 and mwh (multiple wing hair) show dependency on LET while the wi (white-ivory) allele mutants show no dependency.
Nikjoo
H
H
MRC Radiation and Genome Stability Unit, Harwell, Oxfordshire, UK. h.nikjoo@har.mrc.ac.uk
Munson
R J
RJ
Bridges
B A
BA
D000818:Animals; D017122:Bacteriophage T4 / Q000235:genetics / Q000528:radiation effects; D002869:Chromosome Aberrations; D004249:DNA Damage; D004331:Drosophila melanogaster / Q000235:genetics / Q000528:radiation effects; D004926:Escherichia coli / Q000235:genetics / Q000528:radiation effects; D018499:Linear Energy Transfer; D016296:Mutagenesis; D012062:Relative Biological Effectiveness