title: Effect of phased chest and abdominal compression-decompression cardiopulmonary resuscitation on myocardial and cerebral blood flow in pigs.
abstract: OBJECTIVE
  This study was designed to assess the effects of a phased chest and abdominal compression-decompression cardiopulmonary resuscitation (CPR) device, Lifestick, vs. standard CPR on vital organ blood flow in a porcine CPR model.
  
  
  METHODS
  Prospective, randomized laboratory investigation using an established porcine model with instrumentation for measurement of hemodynamic variables, vital organ blood flow, blood gases, and return of spontaneous circulation.
  
  
  METHODS
  University hospital research laboratory.
  
  
  METHODS
  Twelve domestic pigs.
  
  
  METHODS
  After 4 mins of untreated ventricular fibrillation, either the Lifestick CPR device (n = 6) or standard CPR (n = 6) was started and maintained for an additional interval of 6 mins before attempting defibrillation.
  
  
  RESULTS
  During CPR, but before epinephrine, use of the Lifestick CPR device resulted in significantly higher (p < .05) mean (+/- SD) coronary perfusion pressure (23+/-9 vs. 10+/-7 mm Hg), cerebral perfusion pressure (29+/-11 vs. 18+/-10 mm Hg), mean arterial pressure (49+/-10 vs. 36+/-13 mm Hg), end-tidal carbon dioxide (32+/-11 vs. 20+/-7 mm Hg), left ventricular myocardial blood flow (44+/-19 vs. 19+/-12 mL x min(-1) x 100 g(-1)), and total cerebral blood flow (29+/-10 vs. 14+/-12 mL x min(-1) x 100 g(-1)). After 45 microg/kg epinephrine, hemodynamic and vital organ blood flow variables increased to comparable levels in both groups.
  
  
  CONCLUSIONS
  Compared with standard CPR, the Lifestick CPR device increased significantly hemodynamic variables and vital organ blood flow during CPR before epinephrine administration.
authors.affiliation: Department of Anesthesiology, University of Ulm, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Wenzel
authors.forename: K H
authors.initials: KH
authors.lastname: Lindner
authors.forename: A W
authors.initials: AW
authors.lastname: Prengel
authors.forename: H U
authors.initials: HU
authors.lastname: Strohmenger
mesh_terms: D000005:Abdomen; D000704:Analysis of Variance; D000818:Animals; D016887:Cardiopulmonary Resuscitation / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D004837:Epinephrine / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D013552:Swine; D013909:Thorax; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage
chemical_list: D014662:Vasoconstrictor Agents; D004837:Epinephrine