Nasal natural killer cell lymphoma in a post-renal transplant patient.
Posttransplant lymphoproliferative disorders in organ allograft recipients are most commonly of B-cell origin and only occasionally of T-cell origin. We present here a case of nasal natural killer cell lymphoma associated with Epstein-Barr virus that occurred in a recipient of a renal transplant 4 years posttransplantation. Immunohistochemically, the lymphoma cells showed CD2-, surface CD3-, cytoplasmic CD3E+, CD56+, CD57-, CD16-, and CD43+ phenotype. Analyses of T-cell receptor beta and gamma genes showed germ line configurations. EBER-1 was detectable in the lymphoma cells. The patient was diagnosed as having natural killer cell lymphoma and was treated with six courses of combination chemotherapy for non-Hodgkin's lymphoma He has been in remission for more than 3 years thereafter. To the best of our knowledge, this is the first report of a posttransplant NK cell lymphoma associated with Epstein-Barr virus.
Mukai
H Y
HY
Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Kojima
H
H
Suzukawa
K
K
Hori
M
M
Komeno
T
T
Hasegawa
Y
Y
Ninomiya
H
H
Mori
N
N
Nagasawa
T
T
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation; D007694:Killer Cells, Natural; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D008297:Male; D009296:Nasal Cavity / Q000473:pathology; D009669:Nose Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D011183:Postoperative Complications; D012367:RNA, Viral / Q000032:analysis
D015703:Antigens, CD; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral