title: Strong vasopressor support may be futile in the intensive care unit patient with multiple organ failure.
abstract: OBJECTIVE
  The aim of the study was to determine the prognosis in patients who needed norepinephrine treatment in our institution in relation to the degree of organ failure and the evolution of the disease process.
  
  
  METHODS
  Retrospective case note analysis of outcome of those patients who needed norepinephrine according to our institutional regimen.
  
  
  METHODS
  A total of 100 consecutive patients admitted to our 31-bed medical-surgical intensive care unit (ICU) who were treated with norepinephrine for severe hypotension and evidence of end-organ hypoperfusion unresponsive to both fluid resuscitation and dopamine treatment at 20 microg/kg/min.
  
  
  METHODS
  The degree of organ dysfunction at the time of starting norepinephrine treatment was assessed by the sequential organ failure assessment (SOFA) score. The time before starting norepinephrine treatment was defined as the time elapsed between ICU admission and that of starting norepinephrine administration. The patients were defined as survivors or nonsurvivors according to their ICU outcome.
  
  
  RESULTS
  There were relationships between mortality and the degree of organ dysfunction and mortality and the duration of ICU stay before starting norepinephrine treatment. The mortality rate was 100% in the 30 patients with a total SOFA score of >12 and a delay before starting norepinephrine treatment of >1 day. The mortality rate of the other patients was 63%. The lowest mortality was seen in patients with lower SOFA scores and early norepinephrine administration after admission.
  
  
  CONCLUSIONS
  Both the time of starting norepinephrine treatment after admission to the ICU and the degree of organ dysfunction have an important bearing on subsequent outcome. Although norepinephrine may be a lifesaving catecholamine in some cases, its administration to patients who have already developed multiple organ failure during their stay in the ICU is associated with a poor outcome.
authors.affiliation: Department of Intensive Care Medicine, Erasme University Hospital, Free University of Brussels, Belgium.
authors.forename: O
authors.initials: O
authors.lastname: Abid
authors.forename: S
authors.initials: S
authors.lastname: Akça
authors.forename: P
authors.initials: P
authors.lastname: Haji-Michael
authors.forename: J L
authors.initials: JL
authors.lastname: Vincent
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D002648:Child; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000401:mortality / Q000628:therapy*; D009638:Norepinephrine / Q000627:therapeutic use*; D011379:Prognosis; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D017741:Survivors / Q000706:statistics & numerical data; D013997:Time Factors; D017211:Treatment Failure; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D014662:Vasoconstrictor Agents; D009638:Norepinephrine