Removal of Foscarnet by hemodialysis using dialysate-side values.
Foscarnet is an antiviral agent widely used in the treatment of cytomegalovirus (CMV) infection. We describe a cardiac transplant patient, who while being maintained with hemodialysis because of tobramycin-induced acute renal failure, was given Foscarnet for disseminated CMV infection. Using dialysate-side clearance methodology, we found the dialyzer clearance of Foscarnet to be in the order of 89 ml/min.
Sam
R
R
Department of Medicine, Veterans Affairs Hospital, Hines Illinois 60141, USA.
Patel
S B
SB
Popli
A
A
Leehey
D J
DJ
Gambertoglio
J G
JG
Ing
T S
TS
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy*; D000368:Aged; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000009:adverse effects*; D005500:Follow-Up Studies; D017245:Foscarnet / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D007677:Kidney Function Tests; D006435:Renal Dialysis; D013530:Surgical Wound Infection / Q000188:drug therapy / Q000276:immunology; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D017245:Foscarnet