A new selective synthesis of the Ile-allo-Thr-Gly tripeptide fragment of lysobactin.
[formula: see text] trans-Aziridine-2-carboxylic acid derivatives are useful intermediates for the synthesis of threonine or allo-threonine through ring expansion and SN2 displacement, respectively. We describe here the preparation of the Ile-allo-Thr-Gly 11 fragment of Lysobactin via the aziridine 9 intermediate.
Armaroli
S
S
Dipartimento di Chimica G. Ciamician, Università di Bologna, Italy.
Cardillo
G
G
Gentilucci
L
L
Gianotti
M
M
Tolomelli
A
A
D047630:Depsipeptides; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010446:Peptide Fragments / Q000138:chemical synthesis*; D011487:Protein Conformation
D047630:Depsipeptides; D009842:Oligopeptides; D010446:Peptide Fragments; C056790:katanosin B