title: Potential utility of antineoplaston A-10 levels in breast cancer.
abstract: Antineoplastons, first described by Burzynski, are naturally occurring peptides and amino acid derivatives, which control neoplastic growth. Antineoplaston A-10 (3-phenylacetyl amino-2, 6-pepridinedione) is the first chemically identified antineoplaston. Here we describe the potential utility of antineoplaston A-10 as a predictive test for breast cancer. Antineoplaston A-10 level was measured in the urine of 31 breast cancer patients and 17 normal women using high performance thin layer chromatography (HPTLC). Significantly lower antineoplaston A-10 levels were detected among patients with breast cancer with a P value <0.001. These data suggest a strong inverse association of urinary antineoplaston A-10 level with breast cancer. Such finding was the stimulus for further investigations of antineoplaston A-10 levels in some benign as well as other malignant diseases to determine the utility of this approach as a predictive test for women who are at risk of developing breast cancer.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
authors.forename: F
authors.initials: F
authors.lastname: Badria
authors.forename: M
authors.initials: M
authors.lastname: Mabed
authors.forename: W
authors.initials: W
authors.lastname: Khafagy
authors.forename: L
authors.initials: L
authors.lastname: Abou-Zeid
mesh_terms: D000328:Adult; D000368:Aged; D044482:Benzeneacetamides; D001943:Breast Neoplasms / Q000175:diagnosis / Q000652:urine*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D008875:Middle Aged; D010455:Peptides / Q000652:urine*; D010881:Piperidones / Q000652:urine*; D012306:Risk
chemical_list: D044482:Benzeneacetamides; D010455:Peptides; D010881:Piperidones; C052091:antineoplaston A10