Paroxysmal dystonia induced by exercise and acetazolamide.
We report a case of a 40-year-old woman with dystonic attacks precipitated by slight exercise. Episodes lasted 2-5 min and were not precipitated by sudden movements or by being startled, drinking alcohol, coffee or tea, or by stress. Secondary dystonia was ruled out and brain magnetic resonance imaging (MRI) was unremarkable. Routine and video electroencephalogram (EEG) during and between attacks were normal. Acetazolamide greatly worsened her condition, whereas gabapentin [1-(aminomethyl) cyclohexaneacetic acid] treatment markedly reduced the frequency and severity of the episodes.
Guimarães
J
J
Serviço de Neurologia, Hospital de Egas Moniz, Rua da Junqueira, Lisboa, Portugal. jguimaraes@fcm.unl.pt
Vale Santos
J
J
D000085:Acetates / Q000008:administration & dosage*; D000086:Acetazolamide / Q000008:administration & dosage* / Q000009:adverse effects*; D000328:Adult; D000588:Amines; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids; D004421:Dystonia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D015444:Exercise; D005260:Female; D000077206:Gabapentin; D006801:Humans; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D000086:Acetazolamide