title: Osteogenic protein 1 device stimulates bone healing to hydroxyapaptite-coated and titanium implants.
abstract: This study evaluated the effects of osteogenic protein 1 (OP-1) placed in a gap around uncoated and hydroxyapatite (HA)-coated implants. Unloaded cylindrical titanium alloy implants were inserted in the femoral condyles of 16 skeletally mature dogs surrounded by a 3-mm gap. The gap around the implants was filled with 325 microg OP-1 in 130 mg bovine collagen type I as carrier (OP-1 device) or collagen carrier alone or left empty. All groups were tested with both HA-coated and uncoated implants, and the animals were sacrificed after 6 weeks. Implant fixation was determined by push-out test. Bone ongrowth and bone formation were evaluated by quantitative histomorphometry. OP-1 device enhanced mechanical fixation of uncoated and HA-coated implants, resulting in a higher shear strength than implants with collagen matrix and control implants. Bone ingrowth and bone formation in the gap were also stimulated 3-fold for OP-1 groups when compared with empty controls, but no difference was found between OP-1 groups and collagen matrix groups. This study suggests that the OP-1 device placed in a gap around uncoated and HA-coated implants is capable of enhancing mechanical fixation and periimplant bone formation. The collagen carrier alone also enhanced bone ongrowth and fixation significantly.
authors.affiliation: Orthopaedic Research Laboratory, University Hospital of Arhus, Denmark.
authors.forename: M
authors.initials: M
authors.lastname: Lind
authors.forename: S
authors.initials: S
authors.lastname: Overgaard
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.forename: S B
authors.initials: SB
authors.lastname: Goodman
authors.forename: C
authors.initials: C
authors.lastname: Bünger
authors.forename: K
authors.initials: K
authors.lastname: Søballe
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D020099:Coated Materials, Biocompatible; D004285:Dogs; D017886:Durapatite; D016348:Osseointegration / Q000187:drug effects*; D019736:Prostheses and Implants; D014025:Titanium; D016212:Transforming Growth Factor beta / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D020099:Coated Materials, Biocompatible; D016212:Transforming Growth Factor beta; D017886:Durapatite; D014025:Titanium