[Measurement of free triiodothyronine (FT3) using an electrochemiluminescence immunoassay in patients with autoantibodies to triiodothyronine].
Thyroid hormone autoantibodies may lead to abnormal values of free triiodothyronine (FT3) and free thyroxine (FT4) by interference with the radio immunoassay (RIA). We examined thyroid function in six patients with known triiodothyronine-binding autoantibodies using a RIA and an electro-chemiluminescence immunoassay (ECLIA). FT3 values measured by RIA were spuriously high, ECLIA measurement of FT3 led to correct values according to the patients' thyroid status. We conclude from these results that in patients with triiodothyronine-binding autoantibodies FT3 measurement by ECLIA is more useful than measurement by RIA.
Semlitsch
G
G
Abteilung für Innere Medizin und Nuklearmedizin des Krankenhauses der Barmherzigen Brüder Graz-Eggenberg. md.interne@bbegg.at
Buchinger
W
W
Reiterer
E
E
Binter
G
G
Rainer
F
F
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D004563:Electrochemistry / Q000379:methods; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay / Q000379:methods; D015203:Reproducibility of Results; D013959:Thyroid Diseases / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood* / Q000276:immunology*
D001323:Autoantibodies; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine