The nucleolus: the magician's hat for cell cycle tricks.
The nucleolus, for decades considered a ribosome factory and site for ribosomal RNA synthesis and processing, has recently acquired new fame. Analyses of proteins important for cell-cycle regulation have shown that this organelle is used to sequester proteins, thereby inhibiting their activity.
Visintin
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Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Amon
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D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D002466:Cell Nucleolus / Q000378:metabolism*; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005800:Genes, Fungal; D006801:Humans; D008540:Meiosis / Q000502:physiology; D009687:Nuclear Proteins; D017027:Protein Tyrosine Phosphatases; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051736:Proto-Oncogene Proteins c-mdm2; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
C074860:CDC14 protein, S cerevisiae; D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D029701:Saccharomyces cerevisiae Proteins; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D017027:Protein Tyrosine Phosphatases