Rifampicin-resistant bacteriophage PBS2 infection and RNA polymerase in Bacillus subtilis.
Bacteriophage PBS2 replication is unaffected by rifampicin and other rifamycin derivatives, which are potent inhibitors of Bacillus subtilis RNA synthesis. Extracts of gently-lysed infected cells contain a DNA-dependent RNA polymerase activity which is specific for uracil-containing PBS2 DNA. The PBS2-induced RNA polymerase is insensitive to rifamycin derivatives which inhibit the host's RNA polymerase.
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Hitzeman
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Frato
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Lombardi
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D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017103:Bacillus Phages / Q000187:drug effects* / Q000201:enzymology / Q000502:physiology; D001412:Bacillus subtilis / Q000201:enzymology / Q000821:virology*; D002701:Chloramphenicol / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003609:Dactinomycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D008154:Lucanthone / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology*; D012294:Rifamycins / Q000494:pharmacology; D013310:Streptovaricin / Q000494:pharmacology; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D012294:Rifamycins; D014764:Viral Proteins; D013310:Streptovaricin; D003609:Dactinomycin; D002701:Chloramphenicol; C100307:streptolydigin; D012321:DNA-Directed RNA Polymerases; D008154:Lucanthone; D012293:Rifampin