title: Longitudinal course of behavioral problems during Alzheimer's disease: linear versus curvilinear patterns of decline.
abstract: BACKGROUND
  Patients with Alzheimer's Disease (AD) are commonly assumed to experience a linear decline in behavioral functioning that parallels progressive cognitive decline. However, some researchers have suggested that specific behavioral problems either decline at different rates or improve in late dementia.
  
  
  METHODS
  The present analyses examined 150 AD patients at an initial assessment, 61 of whom were also evaluated annually on two additional occasions. Measures of cognitive impairment and behavioral problems were obtained.
  
  
  RESULTS
  Cross-sectional results indicated curvilinear associations between dementia severity and certain behavioral problems (forgetful behaviors, and emotional and impulsive behaviors). Longitudinal analyses further indicated trends for curvilinear rates of behavioral disturbance across time, with some problem areas showing improvement as AD progresses through the most severe stages.
  
  
  CONCLUSIONS
  Even though Alzheimer's disease is a progressive dementia characterized by increasing cognitive deterioration, it appears to be inaccurate to expect behavioral functioning to show the same linear decline across time.
authors.affiliation: Department of Psychology, University of Alabama at Birmingham, 35294, USA.
authors.forename: H J
authors.initials: HJ
authors.lastname: McCarty
authors.forename: D L
authors.initials: DL
authors.lastname: Roth
authors.forename: K T
authors.initials: KT
authors.lastname: Goode
authors.forename: J E
authors.initials: JE
authors.lastname: Owen
authors.forename: L
authors.initials: L
authors.lastname: Harrell
authors.forename: K
authors.initials: K
authors.lastname: Donovan
authors.forename: W E
authors.initials: WE
authors.lastname: Haley
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D001519:Behavior; D003071:Cognition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged