Antileishmanial activities of stearylamine-bearing liposomes.
Here we report the activity of liposomes comprising egg phosphatidylcholine (PC) and stearylamine (SA) against Leishmania donovani parasites. Both promastigotes and intracellular amastigotes in vitro and in vivo were susceptible to SA-PC liposomes. A single dose of 55 mg of SA-PC liposomes/animal could significantly reduce the hepatic parasite burden by 85 and 68% against recent and established experimental visceral leishmaniasis, respectively, suggesting their strong therapeutic potential.
Dey
T
T
Leishmania Group, Indian Institute of Chemical Biology, Calcutta 700032, India.
Anam
K
K
Afrin
F
F
Ali
N
N
D000588:Amines / Q000008:administration & dosage*; D000818:Animals; D003879:Dermatologic Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D007893:Leishmania donovani / Q000187:drug effects*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C
D000588:Amines; D003879:Dermatologic Agents; D004337:Drug Carriers; D008081:Liposomes; C115688:sterylamine