title: Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
abstract: We have identified new activating receptors of the Ig superfamily expressed on human myeloid cells, called TREM (triggering receptor expressed on myeloid cells). TREM-1 is selectively expressed on blood neutrophils and a subset of monocytes and is up-regulated by bacterial LPS. Engagement of TREM-1 triggers secretion of IL-8, monocyte chemotactic protein-1, and TNF-alpha and induces neutrophil degranulation. Intracellularly, TREM-1 induces Ca2+ mobilization and tyrosine phosphorylation of extracellular signal-related kinase 1 (ERK1), ERK2 and phospholipase C-gamma. To mediate activation, TREM-1 associates with the transmembrane adapter molecule DAP12. Thus, TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.
authors.affiliation: Basel Institute for Immunology, Basel, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Bouchon
authors.forename: J
authors.initials: J
authors.lastname: Dietrich
authors.forename: M
authors.initials: M
authors.lastname: Colonna
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D015415:Biomarkers / Q000097:blood; D020013:Calcium Signaling / Q000276:immunology; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005658:Fungi / Q000276:immunology; D006090:Gram-Negative Bacteria / Q000276:immunology; D006094:Gram-Positive Bacteria / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D008262:Macrophage Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000097:blood; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D008970:Molecular Weight; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D005810:Multigene Family / Q000276:immunology; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism* / Q000382:microbiology; D010766:Phosphorylation; D011971:Receptors, Immunologic / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics / Q000502:physiology*; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014443:Tyrosine / Q000097:blood; D015854:Up-Regulation / Q000276:immunology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; C498715:TREM2 protein, human; C110546:TYROBP protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D014443:Tyrosine