Suppression of serum gonadal steroids in rats by chronic treatment with dopamine and serotonin reuptake inhibitors.
The impact of chronic administration (3 weeks) of dopamine and serotonin reuptake inhibitors on serum gonadal steroid hormones and prolactin was studied in intact male and female rats. Both the dopamine and the serotonin reuptake inhibitors lowered serum estradiol and progesterone levels in the female rats. The dopamine transporter blockers suppressed testosterone serum levels in the male rats, whereas serotonin reuptake inhibitors induced only a non-significant reduction (30%) of this hormone. In contrast to the decrease in gonadal steroids, none of the serotonin or the dopamine reuptake blockers altered prolactin serum levels in either the male or female rats. It seems that the effect of these agents on ovarian and testicular hormones is related to the impact of the monoamine reuptake inhibitors on the hypothalamic-pituitary-gonadal axis.
Rehavi
M
M
Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Attali
G
G
Gil-Ad
I
I
Weizman
A
A
D000818:Animals; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D008297:Male; D011374:Progesterone / Q000097:blood*; D051381:Rats; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*; D013739:Testosterone / Q000097:blood*
D018765:Dopamine Uptake Inhibitors; D004958:Estradiol; D011374:Progesterone; D017367:Selective Serotonin Reuptake Inhibitors; D013739:Testosterone