title: A highly enantioselective benzothiepine synthesis
abstract: A highly enantioselective synthesis of benzothiepine 1a has been accomplished via an enantioenriched sulfoxide intermediate obtained by asymmetric oxidation with a chiral oxaziridine in 89:11 er. The key step is a thermodynamically controlled asymmetric cyclization reaction that produces two new stereogenic centers. The (4R,5R) isomer 1a was obtained in 98:2 er.
authors.affiliation: Searle Research & Development, Monsanto Company, St. Louis, Missouri 63017, USA.
authors.initials: CC
authors.lastname: Wang
authors.initials: JJ
authors.lastname: Li
authors.initials: HC
authors.lastname: Huang
authors.initials: LF
authors.lastname: Lee
authors.initials: DB
authors.lastname: Reitz