Polymer-supported reagents and catalysts: recent advances in synthetic applications.
The current surge in parallel array synthesis for the production of small molecule libraries has generated keen interest in the application of solid-supported reagents and catalysts in solution-phase chemistry. The strategy assimilates the advantages of product isolation and purification of solid-phase organic synthesis with the flexible choice of chemistry from the vast repertoire of solution-phase organic reactions. This review summarizes the significant recent advances in the application of polymer-bound reagents and catalysts in solution-phase synthesis of organic molecules. Multi-step reaction sequences employing sequential use of polymer-supported reagents are also discussed. In view of the earlier review publications on this topic, only the recent literature covering 1998 and 1999 is included.
Bhattacharyya
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Argonaut Technologies, San Carlos, CA 94070, USA. sbhattacharyya@argotech.com
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007202:Indicators and Reagents / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D012116:Resins, Plant / Q000737:chemistry
D007202:Indicators and Reagents; D011108:Polymers; D012116:Resins, Plant