title: Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic field.
abstract: Human serum albumin labeled with technetium-99m was encapsulated together with magnetite particles into phosphatidylcholine/cholesterol liposomes. In order to investigate the stability of this complex and its ability to be used for magnetic drug targeting, the in-vivo distribution after intravenous administration in rats was estimated. For in-vivo targeting an SmCo permanent magnet with intensity approximately 0.35 T was attached near the right kidney. Difference between the relative radioactivity in the magnetically targeted right kidney (25.92+/-5.84%) and non-targeted left kidney (0.93+/-0.05%) is sufficiently high for relevant clinical applications.
authors.affiliation: Department of Biophysics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk
authors.forename: M
authors.initials: M
authors.lastname: Babincová
authors.forename: V
authors.initials: V
authors.lastname: Altanerová
authors.forename: M
authors.initials: M
authors.lastname: Lampert
authors.forename: C
authors.initials: C
authors.lastname: Altaner
authors.forename: E
authors.initials: E
authors.lastname: Machová
authors.forename: M
authors.initials: M
authors.lastname: Srámka
authors.forename: P
authors.initials: P
authors.lastname: Babinec
mesh_terms: D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism; D008081:Liposomes; D008280:Magnetics; D010599:Pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D008081:Liposomes