A new cucurbitacin glycoside from Kageneckia oblonga (Rosaceae).
A novel cucurbitacin glycoside has been isolated from aerial parts of Kageneckia oblonga R. et P. and shown to be 3beta-(beta-D-glucosyloxy)-16alpha,23alpha-epoxycuc urbita-5,24-dien-11-one. The structure was established by usual spectroscopic and two-dimensional (2D) NMR techniques. This compound has found to be nontoxic when tested in-vivo cell culture assays. In previous investigations we reported 23,24-dihydrocucurbitacin F and prunasine. This was the first report on cucurbitacins from the genus Kageneckia (Rosaceae).
Muñoz
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O
Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago. omunoz@abello.dic.uchile.cl
Delporte
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C
Backhouse
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N
Erazo
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S
Negrete
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R
Maldonado
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López-Pérez
J L
JL
San Feliciano
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A
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes; D014407:Tumor Cells, Cultured
C412240:3-(glucosyloxy)-16,23-epoxy-cucurbita-5,24-dien-11-one; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes