Towards a circuit engineering discipline.
Genetic circuits can now be engineered that perform moderately complicated switching functions or exhibit predictable dynamical behavior. These 'forward engineering' techniques may have to be combined with directed evolution techniques to produce robustness comparable with naturally occurring circuits.
McAdams
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Department of Developmental Biology, School of Medicine, Stanford University, Stanford 94305, USA. mcadams@cmgm.stanford.edu
Arkin
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A
D004926:Escherichia coli / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D049452:Green Fluorescent Proteins; D007544:Isopropyl Thiogalactoside / Q000494:pharmacology; D008164:Luminescent Proteins; D015202:Protein Engineering; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D008164:Luminescent Proteins; D012097:Repressor Proteins; D049452:Green Fluorescent Proteins; D007544:Isopropyl Thiogalactoside