title: Lymphoid blastic crisis in Philadelphia chromosome-positive chronic granulocytic leukemia following high-grade non-Hodgkin's lymphoma A case report and review of literature.
abstract: In this paper we describe a case of a 65-year old man with a lymphoid blastic crisis of a chronic granulocytic leukemia occurring seven years after a palatine tonsillar non-Hodgkin's lymphoma treated with chemotherapy and radiation therapy. Bone marrow cytogenetic study demonstrated the presence of the typical t(9;22)(q34;q11) and the molecular biology study showed the p210 rearrangement (b2a2). The patient died within a few months, unresponsive to any treatment. This is the first case, described in literature, of a secondary chronic granulocytic leukemia onset with a lymphoid blastic crisis. The authors report the case and a literature review.
authors.affiliation: Istituto di Semeiotica Medica, Università Cattolica del Sacro Cuore, largo Francesco Vito 1, 00168 Rome, Italy. liviop@osa.net
authors.forename: L
authors.initials: L
authors.lastname: Mele
authors.forename: L
authors.initials: L
authors.lastname: Pagano
authors.forename: F
authors.initials: F
authors.lastname: Equitani
authors.forename: P
authors.initials: P
authors.lastname: Chiusolo
authors.forename: E
authors.initials: E
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Zini
authors.forename: L
authors.initials: L
authors.lastname: Teofili
authors.forename: G
authors.initials: G
authors.lastname: Leone
mesh_terms: D000368:Aged; D001752:Blast Crisis / Q000209:etiology*; D001854:Bone Marrow Cells / Q000473:pathology; D003582:Cytogenetics; D017809:Fatal Outcome; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D016609:Neoplasms, Second Primary; D014066:Palatine Tonsil / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D016044:Fusion Proteins, bcr-abl