title: Efficient palladium-catalyzed N-arylation of indoles.
abstract: [equation--see text] The N-arylation of indoles, including a variety of substituted ones, has been carried out using bulky, electron-rich phosphines as the supporting ligand in combination with Pd(2)(dba)(3). Using this catalyst system, the efficient coupling of indole and a variety of substituted indoles with aryl iodides, bromides, chlorides, and triflates can be achieved.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Old
authors.forename: M C
authors.initials: MC
authors.lastname: Harris
authors.forename: S L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D001965:Bromides; D002384:Catalysis; D002712:Chlorides; D015195:Drug Design; D007211:Indoles / Q000737:chemistry*; D007454:Iodides; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium; D013329:Structure-Activity Relationship
chemical_list: D001965:Bromides; D002712:Chlorides; D007211:Indoles; D007454:Iodides; D010165:Palladium