Xenogeneic patch closure of the small intestine: a novel approach to fistula management.
Previous work from our laboratory demonstrated the feasibility of utilizing placental-derived collagen tissue matrix (CTM) as a bowel wall substitute. We reasoned that this technique would also be suitable in managing intestinal fistulae. To test this hypothesis, we created a chronic cecal fistula in rats and randomly managed some with primary repair and others with CTM replacement. Leak rates, mortality, bursting pressures and histologic scores were similar, suggesting that a chronic fistula can be successfully managed with either a CTM or primary repair.
Kirkpatrick
J R
JR
Department of Surgery, Washington Hospital Center, Washington, DC 20010, USA. jmk2@mhg.edu
Nguyen
W D
WD
Kim
D H
DH
Fitzgerald
T L
TL
Provido
H S
HS
Alam
H B
HB
D000818:Animals; D002429:Cecal Diseases / Q000503:physiopathology / Q000601:surgery*; D002432:Cecum / Q000503:physiopathology; D002908:Chronic Disease; D007412:Intestinal Fistula / Q000503:physiopathology / Q000601:surgery*; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D009092:Mucous Membrane / Q000637:transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration; D013552:Swine; D014183:Transplantation, Heterologous