title: Cytogenetics of epithelial hyperplasias of the human breast.
abstract: Generally, benign breast lesions behave like innocuous and limited proliferations; however, sometimes they can represent precancerous pathologies. The cytogenetic analysis of five mammary epithelial hyperplasias is reported. Four cases had clonal chromosome alterations. All of the cases presented a modal number of 46 chromosomes. Chromosome 9 monosomies and chromosome 1 deletions were common in these benign tumors. The study of benign proliferations of the breast may reveal a possible relationship between chromosomal alterations and the conditions of the tissue.
authors.affiliation: Departamento de Genética da Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo, Belém-Pará, Brazil.
authors.forename: R R
authors.initials: RR
authors.lastname: Burbano
authors.forename: A
authors.initials: A
authors.lastname: Medeiros
authors.forename: M I
authors.initials: MI
authors.lastname: de Amorim
authors.forename: E M
authors.initials: EM
authors.lastname: Lima
authors.forename: A
authors.initials: A
authors.lastname: Mello
authors.forename: J B
authors.initials: JB
authors.lastname: Neto
authors.forename: C
authors.initials: C
authors.lastname: Casartelli
mesh_terms: D001941:Breast Diseases / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007621:Karyotyping