Molecular mechanism of monoamine toxicity in Parkinson's disease: hypothetical cell death model.
Although there have been experimental approaches to understanding the etiology of Parkinson's disease, the cause of cell degeneration in this neurological disorder remains a mystery. Herein, a hypothetical model is proposed to explain the mechanism leading neurons to die. The model is based on recent experimental evidence and it attempts to dissect the actions of dopamine and metal ions as potential triggers for the activation of an ordered cascade of events of the cell death machinery.
Jimenez del Rio
M
M
School of Medicine, University of Antioquia, Medellin, Colombia.
Velez-Pardo
C
C
D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology / Q000633:toxicity*; D016923:Cell Death; D004298:Dopamine / Q000502:physiology; D006801:Humans; D008670:Metals; D008959:Models, Neurological; D009474:Neurons / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology* / Q000503:physiopathology*
D015306:Biogenic Monoamines; D008670:Metals; D004298:Dopamine