title: How patients with Parkinson's disease retrieve and manage cognitive event knowledge.
abstract: Several studies have pointed out that basal ganglia are involved in adaptive control of action at both motor and cognitive level. This study aimed to investigate how basal ganglia retrieve and manage script event knowledge required in planning behavior. Script event knowledge was investigated in patients with Parkinson's Disease using three kinds of activity that differed in familiarity. Unlike patients with prefrontal lesions, patients with Parkinson's Disease were able to order events in a typical sequence and obeyed the boundaries and hierarchies between events. In contrast, patients with Parkinson's Disease were impaired in evaluating how important each script event was within the context of goal-oriented planning activity. Our findings indicate that the prefrontal cortex and the basal ganglia are differentially involved in planning. The role of the basal ganglia might consist in providing a feedback about the goodness of each action while building up meaningful sequences of events during learning.
authors.affiliation: Inserm U.289, Hôpital de la Salpêtrière, Paris, France. zalla@isc.cnrs.fr
authors.forename: T
authors.initials: T
authors.lastname: Zalla
authors.forename: A
authors.initials: A
authors.lastname: Sirigu
authors.forename: B
authors.initials: B
authors.lastname: Pillon
authors.forename: B
authors.initials: B
authors.lastname: Dubois
authors.forename: Y
authors.initials: Y
authors.lastname: Agid
authors.forename: J
authors.initials: J
authors.lastname: Grafman
mesh_terms: D000328:Adult; D000368:Aged; D003071:Cognition; D005260:Female; D006801:Humans; D019359:Knowledge; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology*; D011581:Psychological Tests; D012016:Reference Values