Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group.
OBJECTIVE
To report on the prevalence, correlates, and natural history of epiretinal membranes (ERM) in eyes with stage II or III/IV macular holes.


METHODS
A subgroup analysis arising from a multicentered, controlled, randomized clinical trial.


METHODS
Community and university-based ophthalmology clinics.


METHODS
Two hundred twenty four eyes with stage II or III/IV macular holes.


METHODS
No intervention for 100 eyes randomly assigned to observation.


METHODS
Grade of ERM determined by stereoscopic examination of fundus photographs at baseline and at 3, 6, 12, and 24 months of follow-up.


RESULTS
The prevalence of ERM was 65% (145 of 224 eyes), was greater in pseudophakic than in phakic eyes (80% vs. 63%, P = 0.10), and increased with increasing severity of the hole (P < 0.0001). Stage III/IV eyes with ERM had a significantly larger hole size than did eyes without ERM (P < 0.01); however, no association between presence of ERM and visual acuity was found (P > 0.5). In the 100 phakic eyes that were randomly assigned to observation, there was a significant increase in the severity of ERM over follow-up (P < 0.0001).


CONCLUSIONS
ERM are common in eyes with full-thickness idiopathic macular holes. Although ERM prevalence increases with severity and size of the macular hole, the presence of ERM are not closely correlated with visual acuity. These factors may be important in considering the removal of ERM during vitrectomy for macular hole.
Cheng
L
L
Department of Ophthalmology, Shiley Eye Center, University of California San Diego, La Jolla 92093-0946, USA.
Freeman
W R
WR
Ozerdem
U
U
Song
M K
MK
Azen
S P
SP
D002140:California / Q000453:epidemiology; D019773:Epiretinal Membrane / Q000145:classification / Q000453:epidemiology* / Q000503:physiopathology*; D005654:Fundus Oculi; D006801:Humans; D015995:Prevalence; D019591:Pseudophakia / Q000175:diagnosis / Q000453:epidemiology; D012167:Retinal Perforations / Q000145:classification / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D014792:Visual Acuity; D014821:Vitrectomy