Apoptosis and p53 are associated with effect of preoperative radiation in oral squamous cell carcinomas.
This study was carried out to elucidate whether apoptosis and p53 can be used to stratify oral cancer patients into groups with a favorable or unfavorable response to preoperative radiation therapy. Thirty-two patients were evaluated. The apoptosis index was 1.7+/-0. 9% in the ineffective cases, and it was significantly lower than effective cases (3.2+/-1.2%). While 14 of 16 effective cases (86.7%) did not express p53, 13 of 16 ineffective cases (81.3%) overexpressed p53. These results suggest that mutated p53 in tumors is associated with a poor response to radiation which may be related to evasion of apoptosis in oral cancer.
Shintani
S
S
Department of Oral and Maxillofacial surgery II, Okayama University Dental School, 2-5-1, Shikata, Okayama, Japan.
Mihara
M
M
Nakahara
Y
Y
Terakado
N
N
Yoshihama
Y
Y
Kiyota
A
A
Ueyama
Y
Y
Matsumura
T
T
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000528:radiation effects*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000528:radiation effects*
D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53