Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease.
We identified zonulin, a novel human protein analogue to the Vibrio cholerae derived Zonula occludens toxin, which induces tight junction disassembly and a subsequent increase in intestinal permeability in non-human primate intestinal epithelia. Zonulin expression was raised in intestinal tissues during the acute phase of coeliac disease, a clinical condition in which tight junctions are opened and permeability is increased.
Fasano
A
A
Not
T
T
Wang
W
W
Uzzau
S
S
Berti
I
I
Tommasini
A
A
Goldblum
S E
SE
D000328:Adult; D000818:Animals; D002446:Celiac Disease / Q000378:metabolism; D002772:Cholera Toxin / Q000378:metabolism / Q000494:pharmacology*; D004731:Endotoxins; D005333:Fetus; D006242:Haptoglobins; D006801:Humans; D007422:Intestines / Q000187:drug effects*; D008253:Macaca mulatta; D010539:Permeability / Q000187:drug effects; D011498:Protein Precursors
D004731:Endotoxins; D006242:Haptoglobins; D011498:Protein Precursors; C408043:zonulin; C077728:zonula occludens toxin, Vibrio cholerae; D002772:Cholera Toxin