title: Synthesis of 6,8-diazabicyclo
abstract: [formula: see text] Starting with the proteinogenic amino acid (S)-glutamate, a general method for the synthesis of 3-(piperazin-2-yl)propionic acid esters 7 with various substituents at N-4 of the piperazine ring system is presented. An intramolecular ester condensation of 7 is the key step in the formation of the 6,8-diazabicyclo[3.2.2]nonane derivatives 8-10, which are of interest as conformationally restricted piperazines.
authors.affiliation: Pharmazeutisches Institut der Universitat Freiburg, Germany.
authors.initials: M
authors.lastname: Weigl
authors.initials: B
authors.lastname: Wunsch