Synaptic plasticity and dynamic modulation of the postsynaptic membrane.
The biochemical composition of the postsynaptic membrane and the structure of dendritic spines may be rapidly modulated by synaptic activity. Here we review these findings, discuss their implications for long-term potentiation (LTP) and long-term depression (LTD) and propose a model of sequentially occurring expression mechanisms.
Lüscher
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C
Department of Pharmacology (APSIC), CMU, 1, Rue Michel-Servet, Université de Genève, 1211 Geneva 4, Switzerland. christian.luscher@medecine.unige.ch
Nicoll
R A
RA
Malenka
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RC
Muller
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D
D000818:Animals; D048429:Cell Size; D003712:Dendrites / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000502:physiology*; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009433:Neural Inhibition / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D011554:Pseudopodia / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D018091:Receptors, AMPA