[Dopamine-dependent inhibition of glycine release in the rat nucleus accumbens during feeding].
Food intake decreased the glycine extracellular level in the rat n.accumbens. Tetrodotoxin prevented the decrease, whereas D,L-threo-beta-hydroxyaspartic acid exerted no effect. Raclopride (D2 dopamine receptor antagonist) increased the glycine extracellular level in food intake. The data obtained suggest that during feeding the glycine release in the n.accumbens is controlled by the D2 dopamine receptors.
Saul'skaia
N B
NB
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
Mikhaĭlova
M O
MO
Gorbachevskaia
A I
AI
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D065127:Dopamine D2 Receptor Antagonists; D005247:Feeding Behavior / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D008297:Male; D009714:Nucleus Accumbens / Q000378:metabolism*; D020891:Raclopride / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013779:Tetrodotoxin / Q000494:pharmacology
D002121:Calcium Channel Blockers; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; C011274:3-hydroxyaspartic acid; D001224:Aspartic Acid; D018698:Glutamic Acid; D020891:Raclopride; D013779:Tetrodotoxin; D005998:Glycine; D004298:Dopamine