Nitric oxide and interstitial lung disease.
The role and significance of nitric oxide (NO) and its intermediates on interstitial lung diseases are discussed. NO itself has protective roles against lung injury; however, NO is converted to peroxynitrite through the reaction with the superoxide anion at the inflammation foci, resulting in various destructive effects against lung parenchyma. Increased production of NO and peroxynitrite play an important role in oxidative injury and remodeling associated with interstitial lung diseases.
Suga
M
M
First Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Okamoto
T
T
Ando
M
M
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D009566:Nitrates / Q000378:metabolism / Q000502:physiology; D009569:Nitric Oxide / Q000378:metabolism / Q000502:physiology*; D016877:Oxidants / Q000378:metabolism / Q000502:physiology; D013481:Superoxides / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D016166:Free Radical Scavengers; D009566:Nitrates; D016877:Oxidants; D013481:Superoxides; C039642:peroxynitric acid; D009569:Nitric Oxide