title: Successful high dose therapy for relapsed mediastinal large B cell lymphoma following surgical repair of anterior chest wall defect.
abstract: We describe a man with relapsed large B cell mediastinal lymphoma and associated infected large anterior chest wall defect who required high dose salvage therapy for his underlying disease. An initial mediastinotomy wound, associated with recurrent sepsis, had developed into an abscess, then fistula and eventually a large anterior chest wall defect. Safe use of salvage chemotherapy required reconstructive surgery consisting of a pedicled muscle flap. The subsequent high dose chemotherapy was carried out without complications and 15 months later the patient is alive and well.
authors.affiliation: Department of Haematology and Department of Plastic Surgery, Christchurch Hospital, New Zealand.
authors.forename: F R
authors.initials: FR
authors.lastname: MacLean
authors.forename: J P
authors.initials: JP
authors.lastname: Hanley
authors.forename: W N
authors.initials: WN
authors.lastname: Patton
authors.forename: D N
authors.initials: DN
authors.lastname: Hart
authors.forename: S
authors.initials: S
authors.lastname: Langley
authors.forename: K
authors.initials: K
authors.lastname: Bayston
authors.forename: G M
authors.initials: GM
authors.lastname: Jeffery
mesh_terms: D000038:Abscess / Q000209:etiology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005402:Fistula / Q000209:etiology / Q000601:surgery; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods*; D012008:Recurrence; D016879:Salvage Therapy; D018805:Sepsis / Q000601:surgery; D019616:Thoracic Surgical Procedures / Q000379:methods*; D013909:Thorax / Q000382:microbiology* / Q000473:pathology