title: The effect of nutritional supplementation on survival in seriously ill hospitalized adults: an evaluation of the SUPPORT data. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments.
abstract: Enteral tube and parenteral hyperalimentation are widely used nutritional support systems. Few studies examine the relation between nutritional support and patient outcomes in seriously ill hospitalized adults.
  
  
  
  To explore the association between nutritional support and survival in seriously ill patients enrolled in the Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT).
  
  
  
  A prospective study of preferences, decision-making, and outcomes.
  
  
  
  Five teaching hospitals
  
  
  
  6298 patients aged 18 or older meeting diagnostic and illness severity criteria.
  
  
  
  Demographic characteristics, diagnoses, comorbid conditions, acute physiology score, nutritional support, and functional status before hospitalization.
  
  
  
  A total of 2149 patients received nutritional support. In patients who received artificial nutrition on hospital days 1 or 3 (Cohort 1), enteral feeding was associated with improved survival in coma (hazard: 0.53; 95%CI, 0.42-0.66), and reduced survival in COPD (hazard: 1.57; 95%CI, 1.18-2.08). In patients who were hospitalized on Day 7 and received artificial nutrition on days 1, 3, or 7 (Cohort 2), enteral tube feeding (hazard: 0.35; 95%CI, 0.27-0.46) or hyperalimentation (hazard: 0.58; 95%CI, 0.38-0.90) was associated with improved survival in coma. Tube feeding was associated with decreased survival in acute respiratory failure (ARF) or multiorgan system failure (MOSF) with sepsis (hazard: 1.21; 95%CI, 10.4-1.41), cirrhosis (hazard: 2.15; 95%CI, 1.35-3.42), and COPD (hazard: 1.37; 95%CI, 1.04-1.80). Hyperalimentation was associated with decreased survival in ARF or MOSF with sepsis (hazard: 1.34; 95%CI, 1.12-1.59).
  
  
  
  Nutritional support was associated with improved survival in coma. Enteral feeding and hyperalimentation was associated with decreased survival in ARF or MOSF with sepsis. Tube feeding was associated with decreased survival in cirrhosis and COPD. Except for patients in coma, artificial nutrition was not associated with a survival advantage.
authors.affiliation: Department of Medicine, The George Washington University Medical Center, Washington, DC 20037, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Borum
authors.forename: J
authors.initials: J
authors.lastname: Lynn
authors.forename: Z
authors.initials: Z
authors.lastname: Zhong
authors.forename: K
authors.initials: K
authors.lastname: Roth
authors.forename: A F
authors.initials: AF
authors.lastname: Connors
authors.forename: N A
authors.initials: NA
authors.lastname: Desbiens
authors.forename: R S
authors.initials: RS
authors.lastname: Phillips
authors.forename: N V
authors.initials: NV
authors.lastname: Dawson
mesh_terms: D000328:Adult; D000368:Aged; D003657:Decision Making; D004750:Enteral Nutrition; D005260:Female; D006760:Hospitalization; D006801:Humans; D008020:Life Support Care; D008103:Liver Cirrhosis / Q000145:classification / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000145:classification / Q000401:mortality / Q000628:therapy*; D010289:Parenteral Nutrition, Total; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000145:classification / Q000401:mortality / Q000628:therapy*; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States