Tumor regression by inductive hyperthermia combined with hepatic embolization using dextran magnetite-incorporated microspheres in rats.
We formulated a novel preparation of microspheres incorporating dextran magnetite complex (DM-MS), which enable magnetic field-induced heating for the induction of hyperthermia. Using a 500 kHz magnetic field combined with arteriolar embolization of DM-MS, inductive hyperthermia was performed for the treatment of liver tumors in rats. Three days after treatment, the percentage increase of tumor volume in the embolo-hyperthermia, embolization alone, and control groups were 28%, 124%, and 385%, respectively, with the embolo-hyperthermia group differing significantly from the remaining groups. This study demonstrated the feasibility of combining embolization of DM-MS with hyperthermia as an antitumor therapy.
Minamimura
T
T
Second Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
Sato
H
H
Kasaoka
S
S
Saito
T
T
Ishizawa
S
S
Takemori
S
S
Tazawa
K
K
Tsukada
K
K
D000818:Animals; D002279:Carcinoma 256, Walker / Q000628:therapy; D003131:Combined Modality Therapy; D003911:Dextrans / Q000627:therapeutic use*; D004621:Embolization, Therapeutic / Q000379:methods*; D052203:Ferrosoferric Oxide; D006979:Hyperthermia, Induced; D007501:Iron / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008863:Microspheres; D010087:Oxides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide