title: High-resolution segmented EPI in a motor task fMRI study.
abstract: A high-resolution gradient echo, multi-slice segmented echo planar imaging method was used for functional MRI (fMRI) using a motor task at 1.5 Tesla. Functional images with an in-plane resolution of 1 mm and slice thickness of 4 mm were obtained with good white-gray matter contrast. The multi-shot approach, combined with a short total readout period of 82 ms, limits blurring effects for short T(2)(*) tissues (such as gray matter), assuring truly high-resolution images. In all subjects, motor functions were clearly depicted in the contralateral central sulcus over several slices and sometimes activation was detected in the supplementary motor area and/or ipsilateral central sulcus. The average signal change of 11+/-3% was much higher than in standard low-resolution fMRI EPI experiments, as a result of larger relative blood fractions.
authors.affiliation: Department of Clinical Physics & Informatics, University Hospital Vrije Universiteit, De Boelelaan 1117, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. fgc.hoogenraad@azvu.nl
authors.forename: F G
authors.initials: FG
authors.lastname: Hoogenraad
authors.forename: P J
authors.initials: PJ
authors.lastname: Pouwels
authors.forename: M B
authors.initials: MB
authors.lastname: Hofman
authors.forename: S A
authors.initials: SA
authors.lastname: Rombouts
authors.forename: C
authors.initials: C
authors.lastname: Lavini
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: E M
authors.initials: EM
authors.lastname: Haacke
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D017352:Echo-Planar Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D009068:Movement / Q000502:physiology*; D013933:Thumb