Regio- and stereocontrolled metal-mediated carbonyl propargylation or allenylation of enantiomerically pure azetidine-2,3-diones: synthesis of highly functionalized 3-substituted 3-hydroxy-beta-lactams
Regio- and stereocontrolled metal-mediated Barbier-type reactions of azetidine-2,3-diones with differently substituted propargyl bromides offer an efficient asymmetric entry to densely functionalized 3-propargyl- (or allenyl-) substituted 3-hydroxy-beta-lactams.
Alcaide
B
Departamento de Quimica Organica I, Facultad de Ciencias Quimicas, Universidad Complutense, 28040-Madrid, Spain.
Almendros
P
Aragoncillo
C