Generic models for radionuclide dosimetry: 11C-, 18F- or 75Se-labelled amino acids.
A generic biokinetic model was developed for use in the assessment of the internal dose received by human subjects injected with amino acids labelled with 11C (T1/2 = 0.34 h, beta+, gamma), 18F(T1/2 = 1.83 h, beta+, gamma) or 75Se (T1/2 = 119.8 d, beta-, gamma). This generic model was used in conjunction with the MIRDOSE 3 computer programme to calculate radiation doses to adults; these radiation doses were compared with those calculated using compound-specific models for two [11C]-, and eight [18F]-labelled amino acids and [75Se]selenomethionine. In general, the effective doses, as well as the organ and tissue doses, calculated using the generic model agreed within a factor of 2 or less, with those calculated using compound-specific models; the generic model tended to over-, rather than underestimate the organ and tissue doses. It was concluded that for 11C- and 18F-labelled amino acids and for 75Se-labelled amino acids or their analogues, the single generic biokinetic model could be applied for general radiation protection purposes.
Taylor
D M
DM
Department of Chemistry, Cardiff University, Wales, UK.
D000328:Adult; D000596:Amino Acids / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics*; D006801:Humans; D008715:Methionine / Q000737:chemistry; D008954:Models, Biological; D011829:Radiation Dosage; D015203:Reproducibility of Results; D012644:Selenium Radioisotopes / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014364:Tryptophan / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D014443:Tyrosine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D010135:p-Fluorophenylalanine / Q000493:pharmacokinetics
D000596:Amino Acids; D002250:Carbon Radioisotopes; D005462:Fluorine Radioisotopes; D012644:Selenium Radioisotopes; C001244:6-fluorotryptophan; D014443:Tyrosine; D010135:p-Fluorophenylalanine; C060489:2-fluorotyrosine; D014364:Tryptophan; D008715:Methionine