Enantioselective synthesis of 2-substituted cyclobutanones
[formula: see text] An enantioselective synthesis of 2-substituted cyclobutanones has been achieved by sequential application of the titanium-mediated cyclopropanation of alpha-hydroxy esters and the pinacol-type rearrangement of the resulting alpha-hydroxycyclopropylcarbinols.
Cho
SY
Department of Chemistry, University of Alabama, Tuscaloosa 35487, USA.
Cha
JK