Synthesis, DNA-binding, and antiviral activity of certain pyrazolo[3,4-d]pyrimidine derivatives.
Some new pyrazolo[3,4-d]pyrimidine derivatives have been prepared and tested for their antiviral and DNA-binding activities. Compounds 4, 5, and 6 showed high binding affinity to DNA at concentrations of 19, 27, and 28 micrograms/ml, respectively. On the other hand, compounds 6 and 10 reduced the number of viral plaques of Herpes simplex type-1 (HSV-1) by 66 and 41%, respectively. The detailed synthesis and spectroscopic and biological data are reported.
el-Bendary
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Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Badria
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D016590:Aphidicolin / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002522:Chlorocebus aethiops; D004247:DNA / Q000378:metabolism*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D011720:Pyrazoles / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D014709:Vero Cells
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011720:Pyrazoles; D011743:Pyrimidines; D016590:Aphidicolin; D004247:DNA