The total synthesis of pantocin B.
[reaction: see text] Pantocin B, an unusual antibiotic produced by Erwinia herbicola, effectively controls E. amylovora, the pathogen causing the plant disease fire blight. A total synthesis of pantocin B from L-alanine, glycine, and L-malic acid is reported.
Sutton
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AE
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853-1301, USA.
Clardy
J
J
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004885:Erwinia / Q000737:chemistry / Q000187:drug effects; D005998:Glycine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008293:Malates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010935:Plant Diseases / Q000382:microbiology
D000900:Anti-Bacterial Agents; D008293:Malates; C410984:pantocin B; D001120:Arginine; D005998:Glycine