title: Tonic motor activity of the narrow gastric tube used as an oesophageal substitute.
abstract: OBJECTIVE
  To assess the compliance, the existence of basal tone, the sensory response to distension, and the integrity of the neurohumoral enterogastric inhibitory reflex of the narrow gastric tube as an oesophageal substitute.
  
  
  METHODS
  Explanatory experimental study.
  
  
  METHODS
  University hospital, The Netherlands.
  
  
  METHODS
  Eight patients after oesophagectomy, formation of a narrow gastric tube, and cervical gastro-oesophagostomy.
  
  
  METHODS
  Measurements of intragastric tonic motor activity with a Barostat.
  
  
  METHODS
  Compliance, sensations during stepwise pressure increments, and changes in tone induced by glucagon and intraduodenal feeding.
  
  
  RESULTS
  The compliance of the narrow gastric tube was found to be low (median 13.5 ml/mmHg (range 5-21)). Most of the patients perceived minimal sensation on distension. All patients had phasic tonic contractions during distension of the gastric tube. The median (range) relaxation after glucagon had been given intravenously was 14 ml (range 3-57) (p < 0.05). The tonic reaction to nutrients in the duodenum was not significant.
  
  
  CONCLUSIONS
  The compliance of the narrow gastric tube is low. Postprandial symptoms are not caused by distension of the proximal part of the narrow gastric tube. Basal gastric tone and phasic activity were at least partially restored over time after operation. The enterogastric inhibitory reflex is eliminated by oesophageal resection and reconstruction of a gastric tube.
authors.affiliation: Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Logeman
authors.forename: J M
authors.initials: JM
authors.lastname: Roelofs
authors.forename: H
authors.initials: H
authors.lastname: Obertop
authors.forename: L M
authors.initials: LM
authors.lastname: Akkermans
mesh_terms: D000328:Adult; D000368:Aged; D002299:Cardia / Q000601:surgery; D004938:Esophageal Neoplasms / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005746:Gastric Emptying; D005765:Gastrointestinal Agents / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011312:Pressure; D013270:Stomach / Q000637:transplantation*
chemical_list: D005765:Gastrointestinal Agents; D005934:Glucagon