title: A novel synthesis of 2-aryl-2H-indazoles via a palladium-catalyzed intramolecular amination reaction.
abstract: [reaction: see text] A variety of 2-aryl-2H-indazoles were synthesized by the palladium-catalyzed intramolecular amination of the corresponding N-aryl-N(o-bromobenzyl)hydrazines. Of several sets of reaction conditions surveyed, the combination of Pd(OAc)2/dppf/tBuONa gave the best results. This method applies to a wide scope of substrates containing electron-donating and electron-withdrawing substituents.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut 06877-0368, USA. jsong@rdg.boehringer-ingelheim.com
authors.forename: J J
authors.initials: JJ
authors.lastname: Song
authors.forename: N K
authors.initials: NK
authors.lastname: Yee
mesh_terms: D000586:Amination; D002384:Catalysis; D007191:Indazoles / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*
chemical_list: D007191:Indazoles; D010165:Palladium