title: A case of bilateral heel ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia.
abstract: Bilateral heel skin ulcers developed in a 50-year-old male in the chronic phase of chronic myelogenous leukemia who had been receiving hydroxyurea (HU) therapy for 3 years. Histological examination showed perivascular lymphocytic inflammation without vasculitis. After interruption of HU administration, the heel ulcers were completely resolved within 2 months. The clinical course strongly suggested that the heel ulcers were induced by long-term HU therapy.
authors.affiliation: Department of Hematology, Jichi Medical School, Tochigi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tarumoto
authors.forename: S
authors.initials: S
authors.lastname: Imagawa
authors.forename: T
authors.initials: T
authors.lastname: Hotta
authors.forename: K
authors.initials: K
authors.lastname: Ohmine
authors.forename: T
authors.initials: T
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Takatoku
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Hatake
authors.forename: K
authors.initials: K
authors.lastname: Ozawa
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D016523:Foot Ulcer / Q000139:chemically induced* / Q000473:pathology; D006365:Heel; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D006918:Hydroxyurea