Lack of acute cyclosporine nephrotoxicity in late heart-transplant recipients.
BACKGROUND
Cyclosporine induces daily renal hypoperfusion in subjects with normal atrial natriuretic peptide (ANP) levels, but its acute effects in heart transplant patients with increased ANP remain to be determined.


METHODS
Cyclosporinemia and creatinine clearance were monitored during 7 hours following cyclosporine administration in 6 heart transplant patients.


RESULTS



CONCLUSIONS
No acute cyclosporine-induced decrease in creatinine clearance was observed after heart transplantation. These data suggest that maintenance cyclosporine dose may be less nephrotoxic than suspected and that increased ANP might protect the renal function late after heart transplantation.
Piquard
F
F
Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Faculté de Médecine, and Service d'Explorations Fonctionnelles Physiologiques, Hôpitaux Universitaires, Strasbourg, France.
Geny
B
B
Hardy
H
H
Chakfe
N
N
Mettauer
B
B
Charloux
A
A
Lampert
E
E
Lonsdorfer
J
J
D000208:Acute Disease; D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006084:Graft Rejection / Q000097:blood / Q000517:prevention & control*; D006333:Heart Failure / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D015415:Biomarkers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009320:Atrial Natriuretic Factor; D003404:Creatinine