Determination of Lufenuron in canine skin layers by radioluminography.
In a bioavailability study in dogs we investigated the quantity of [14C]-Lufenuron and its metabolites in the skin by radioluminography. Two Beagle dogs were orally administered 10 mg [14C]-Lufenuron per kg body weight. 21 days later they were euthanized. Skin specimens were taken at 6 different sites. Sections of these skin specimens were exposed on a phosphorus imaging plate and the radiolabeled Lufenuron content visualized. Radioluminographical analysis showed that [14C]-Lufenuron appeared in the subcutaneous layer of the skin. We did not discover any activity on the skin surface.
Hotz
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RP
Novartis Animal Health Inc., Centre de Recherche Santé Animale S.A., St. Aubin.
Hassler
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S
Maurer
M P
MP
D000818:Animals; D001549:Benzamides / Q000032:analysis* / Q000493:pharmacokinetics; D002250:Carbon Radioisotopes; D004285:Dogs / Q000378:metabolism*; D004350:Drug Residues / Q000032:analysis* / Q000493:pharmacokinetics; D005260:Female; D007306:Insecticides / Q000032:analysis* / Q000493:pharmacokinetics; D008163:Luminescent Measurements; D008297:Male; D012867:Skin / Q000737:chemistry* / Q000378:metabolism; D005466:Fluorocarbons
D001549:Benzamides; D002250:Carbon Radioisotopes; D007306:Insecticides; C070364:fluphenacur; D005466:Fluorocarbons