title: A synthetic peptide of human apoprotein E with antibacterial activity.
abstract: In recent years, several endogenous mammalian antibacterial peptides have been described. An amphipathic cationicalpha-helix is a common feature in many cases; therefore, other peptides with this characteristic might also possess antibiotic activity. In fact, a 30-mer peptide of apoprotein E 133-162 (LRVRLASHLRKLRKRLLRDADDLQKRLAVY) was found to have antibiotic activity comparable to those of a classic antibiotic (Gentamicin) and a neutrophil-derived antibiotic peptide (CAP18). Calculation of cationicity, hydrophobicity, and hydrophobic moment and the helical wheel diagram of apoprotein E 133-162 revealed close similarities to CAP18.
authors.affiliation: Department of Ecological Engineering, Toyohashi University of Technology, Hibarigaoka 1-1, Tenpaku-cho, Toyohashi-shi, Aichi-ken, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Azuma
authors.forename: T
authors.initials: T
authors.lastname: Kojimab
authors.forename: I
authors.initials: I
authors.lastname: Yokoyama
authors.forename: H
authors.initials: H
authors.lastname: Tajiri
authors.forename: K
authors.initials: K
authors.lastname: Yoshikawa
authors.forename: S
authors.initials: S
authors.lastname: Saga
authors.forename: C A
authors.initials: CA
authors.lastname: Del Carpio
mesh_terms: D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D001057:Apolipoproteins E / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002352:Carrier Proteins / Q000494:pharmacology; D054804:Cathelicidins; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017433:Protein Structure, Secondary; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012475:Salmonella / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001057:Apolipoproteins E; D002352:Carrier Proteins; D054804:Cathelicidins; D005839:Gentamicins; D010446:Peptide Fragments