[Relationship between change of erythrocyte membrane lipid composition and pregnancy induced hypertension].
OBJECTIVE
To study the cause of decreased erythrocyte deformability and its relation to pregnancy induced hypertension (PIH).


METHODS
The cholesterol and phospholipid content of erythrocyte membrane in 24 non-pregnant healthy women, 22 normotensive pregnant women and 36 cases with PIH were determined using automatic biochemical analysor, Gas chromatography and modified colorimetric method.


RESULTS
The cholesterol content and the cholesterol/phospholipid (C/P) ratio of the erythrocyte membrane were obviously higher in the group with moderate or severe PIH than that in the nonmotensive pregnancies (P < 0.01). There was no significant difference between mild PIH group and the normotensive pregnant group (P > 0.05).


CONCLUSIONS
The increase of cholesterol content and C/P ratio in the erythrocyte membrane might be involved in the pathophysiology of PIH. The alteration of cholesterol content in the erythrocyte membrane probaby reflected the disturbance of serum lipid metabolism.
Li
H
H
Henan Medical Staff College, Zhengzhou.
Ren
F
F
Liu
W
W
D000328:Adult; D002784:Cholesterol / Q000378:metabolism*; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D010743:Phospholipids / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D010743:Phospholipids; D002784:Cholesterol