[Exposure to chloroprene as an occupational hazard (a cohort epidemiologic study)].
A cancer epidemiological study was conducted in chloroprene workers in Yerevan. In a cohort of male workers, the total morbidity rates for all tumor patterns were significantly lower (32%) than expected, which was attributed to the effect of "the healthy worker". Risk for hepatic tumor was 3.83 times the expected level among male operators of the chloroprene production equipment. A direct "dose-effective" correlation was established between liver cancer risk and length of record for occupational exposure to chloroprene. The highest risk was among males who came into contact with the substance under the age of 30.
Bul'bulian
M A
MA
Research Institute of Carcinogenesis, N.N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow.
Margarian
A G
AG
D000328:Adult; D000367:Age Factors; D000397:Air Pollution / Q000009:adverse effects / Q000706:statistics & numerical data*; D001136:Armenia / Q000453:epidemiology; D002273:Carcinogens / Q000009:adverse effects*; D002737:Chloroprene / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects / Q000706:statistics & numerical data*; D012189:Retrospective Studies
D002273:Carcinogens; D002737:Chloroprene