Effects of exercise and alkalosis on serum insulin-like growth factor I and IGF-binding protein-3.
This investigation examines the effects of orally induced alkalosis on serum IGF-I and IGFBP3 concentrations in response to an acute 90-s bout of high intensity cycle exercise. Ten healthy, active men, ages 24.60 +/- 4.90 years, participated in a randomized, double-blind, counterbalanced trial order with a cross-over design. Subjects ingested an experimental bicarbonate solution or a placebo solution. Blood was sampled at baseline; pre-exercise; and 0, 5, 10, and 30 min postexercise. The pH between groups for pre-exercise and postexercise time points differed significantly (p < or = .05) in the experimental condition (from 7.42 +/- 0.01 to 7.35 +/- 0.02) versus the placebo condition (from 7.36 +/- 0.01 to 7.25 +/- 0.03). Increases in IGF-I over resting conditions occurred with placebo conditions at 5 and 10 min postexercise and in the experimental condition at 5 min postexercise. Concentrations of IGFBP3 were elevated above baseline at IP in both experimental and placebo conditions.
Kraemer
W J
WJ
The Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA.
Harman
F S
FS
Vos
N H
NH
Gordon
S E
SE
Nindl
B C
BC
Marx
J O
JO
Gómez
A L
AL
Volek
J S
JS
Ratamess
N A
NA
Mazzetti
S A
SA
Bush
J A
JA
Dohi
K
K
Newton
R U
RU
Häkkinen
K
K
D000293:Adolescent; D000328:Adult; D000471:Alkalosis / Q000097:blood* / Q000503:physiopathology; D000704:Analysis of Variance; D001639:Bicarbonates / Q000008:administration & dosage; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D010919:Placebos
D001639:Bicarbonates; D018972:Insulin-Like Growth Factor Binding Protein 3; D010919:Placebos; D007334:Insulin-Like Growth Factor I