The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans.
Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-gamma2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P= 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans.
Cole
S A
SA
Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA. scole@darwin.sfbr.org
Mitchell
B D
BD
Hsueh
W C
WC
Pineda
P
P
Beamer
B A
BA
Shuldiner
A R
AR
Comuzzie
A G
AG
Blangero
J
J
Hixson
J E
JE
D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D013781:Texas; D014157:Transcription Factors / Q000235:genetics*; D044465:White People / Q000235:genetics*
D020738:Leptin; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors