Effect of fluoride salts on metal-mediated reactions. Aluminum/fluoride salt-mediated reduction and pinacol coupling of carbonyl compounds in aqueous media
[formula: see text] Metal fluoride salts were found to activate aluminum in water to react with carbonyl compounds to give the pinacol coupling products and/or the reduced alchohols. The metal ion of the fluoride salt was found to play a role in controlling the chemoselectivity and stereoselectivity of the reaction.
Li
LH
Department of Chemistry, McGill University, Montreal, Quebec, Canada.
Chan
TH