Hyperoxia-enhanced activation-induced hemodynamic response in human VI: an fMRI study.
The effect hyperoxia had on the hemodynamic response to visual stimulation (black and white checkerboard alternating at a frequency of 8 Hz) of human VI was investigated using a blood oxygenation level-dependent (BOLD) contrast with an fMRI technique. Data were acquired with a 5 on/5 off block paradigm using single-shot gradient-echo echo-planar imaging. Using a two-tailed paired t-test (p < 0.05, n = 13) it was found that the mean percentage signal change and the mean number of activated pixels was significantly increased for hyperoxia (5.7 +/- 0.9, 187 +/- 73, mean +/- SD) relative to those for normoxia (5.4 +/- 0.9, 168 +/- 58). We believe that these results indicate that hyperoxia enhances the activation-induced hemodynamic response in human VI.
Kashikura
K
K
Akita Laboratory, Japan Science and Technology Corporation (JST), Japan.
Kershaw
J
J
Kashikura
A
A
Matsuura
T
T
Kanno
I
I
D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D018496:Hyperoxia / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D010100:Oxygen / Q000097:blood; D014793:Visual Cortex / Q000473:pathology* / Q000503:physiopathology*
D010100:Oxygen