title: Reaction of bony tissue to implanted silver glass ionomer and a reinforced zinc oxide-eugenol cement.
abstract: OBJECTIVE
  To evaluate the tissue responses to implants of Ketac Silver and Super EBA cement in the guinea pig mandible.
  
  
  METHODS
  Sixteen guinea pigs were used for 2 experimental periods of 4 and 12 weeks. Both materials were placed in Teflon applicators and implanted into surgically prepared sites in the mandible. A histologic examination for reaction to the material occurred after the animals were killed and processed.
  
  
  RESULTS
  After 4 weeks, minimal inflammatory reactions were observed in Ketac Silver implants, whereas the Super EBA implants showed minimal to moderate inflammation. Localized foreign body reaction was present in areas of fragmented small particles of Ketac Silver. At 12-weeks observation, no inflammatory reactions were present around either material. Direct bone contact was observed in 1 Ketac Silver implant.
  
  
  CONCLUSIONS
  Ketac Silver and Super EBA cement elicited mild reactions under the conditions of this model. From a biologic point of view, these 2 materials may offer equal utility in endodontic surgery.
authors.affiliation: Department of Endodontology, School of Dental Medicine, University of Connecticut Health Center, Framington, Connecticut, USA.
authors.forename: E
authors.initials: E
authors.lastname: Pissiotis
authors.forename: L
authors.initials: L
authors.lastname: Spângberg
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D016722:Cermet Cements / Q000633:toxicity*; D017220:Dentin-Bonding Agents / Q000633:toxicity*; D006168:Guinea Pigs; D008297:Male; D008334:Mandible / Q000187:drug effects; D012387:Root Canal Filling Materials / Q000633:toxicity*
chemical_list: D016722:Cermet Cements; D017220:Dentin-Bonding Agents; D012387:Root Canal Filling Materials; C084074:Super EBA