title: In vitro antimicrobial activity of gatifloxacin against 873 clinical isolates from respiratory tract, urinary tract and surgical infections during 1997-1998 in Japan.
abstract: The in vitro activity of gatifloxacin was determined for 873 isolates from various infections during 1997-1998 in Japan. Gatifloxacin was active against streptococci, Escherichia coli, Klebsiella pneumoniae, Moraxella catarrhalis, Haemophilus influenzae and Neisseria gonorrhoeae, with MIC(90)s of </=0.39 mg/L. The activity was two- to 32-fold greater than that of ciprofloxacin and levofloxacin against Gram-positive bacteria, and comparable to that against Gram-negative bacteria. Gatifloxacin was more active than the other quinolones against quinolone-resistant staphylococci, Enterococcus faecalis, E. coli and Enterobacter cloacae. It also had good activity against penicillin- or macrolide-resistant Streptococcus pneumoniae and ampicillin-resistant H. influenzae.
authors.affiliation: Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd, 2399-1 Mitarai, Nogi, Shimotsuga, Tochigi 329-0114, Japan. fvbb0984@mb.infoweb.ne.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Tsurumaki
authors.forename: H
authors.initials: H
authors.lastname: Manda
authors.forename: M
authors.initials: M
authors.lastname: Takei
authors.forename: M
authors.initials: M
authors.lastname: Hosaka
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D024841:Fluoroquinolones; D000077734:Gatifloxacin; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D012141:Respiratory Tract Infections / Q000382:microbiology*; D013530:Surgical Wound Infection / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin