Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis.
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Eucalyptus plants were screened. Consequently, the phlorogrucinol-monoterpene derivative, euglobal-G1 (EG-1), was obtained from the leaves of Eucalyptus grandis as an active constituent. EG-1 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA) as an initiator and fumonisin-B1, which has been known as one of mycotoxins produced by Fusarium monifliforme, as a promoter. Further, EG-1 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumor using 4-nitroquinoline-N-oxide (4-NQO) as an initiator and glycerol as a promoter.
Takasaki
M
M
Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan.
Konoshima
T
T
Etoh
H
H
Pal Singh
I
I
Tokuda
H
H
Nishino
H
H
D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology; D001835:Body Weight; D002264:Carboxylic Acids; D002273:Carcinogens; D002274:Carcinogens, Environmental; D005052:Eucalyptus / Q000627:therapeutic use*; D005260:Female; D037341:Fumonisins; D005990:Glycerol; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D018632:Mice, Inbred SENCAR; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
D016588:Anticarcinogenic Agents; D000998:Antiviral Agents; D002264:Carboxylic Acids; D002273:Carcinogens; D002274:Carcinogens, Environmental; D037341:Fumonisins; D013729:Terpenes; C065477:euglobal G1; C056933:fumonisin B1; D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D010696:Phloroglucinol; D005990:Glycerol