[The effect of intraocular lidocaine in white rabbit eyes].
OBJECTIVE
Recently, intraocular lidocaine anesthesia has been used in cataract surgery. We studied the toxicity of intraocular unpreserved lidocaine for corneal endothelial cell and retina using Japanese white rabbits.


METHODS
They were divided into two groups. One group was injected intracamerally and the other group was injected intravitreally with 0.2 ml of unpreserved lidocaine of 0%, 0.02%, 0.2%, or 2% concentration. The number of corneal endothelial cells was measured 1 week after the injection. The rabbits were killed after measurements, and their corneas were studied histologically. The retina was examined by electroretinogram from before the injection through 1 week after the injection.


RESULTS
There was no significant change in number of corneal endothelial cells after injection of 0.2% lidocaine. However, histological abnormality was seen in corneal endothelial cells after 2% lidocaine injection. There was also significant change in electroretinogram with 2% lidocaine injection. No histological abnormality was seen in the retina 1 week after the injection.


CONCLUSIONS
The rabbit cornea and retina manifested no serious changes after the injection of lidocaine at less than 0.2% concentration functionally and histologically.
Nishide
T
T
Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Kadonosono
K
K
Itoh
N
N
Yazama
F
F
Endoh
Y
Y
Sawada
H
H
Ohno
S
S
D000772:Anesthesia, Local / Q000379:methods; D000818:Animals; D002387:Cataract Extraction / Q000379:methods*; D003315:Cornea / Q000187:drug effects; D007267:Injections; D008012:Lidocaine / Q000008:administration & dosage*; D011817:Rabbits; D012160:Retina / Q000187:drug effects
D008012:Lidocaine