Polycystic kidney disease in bull terriers: an autosomal dominant inherited disorder.
The prevalence, mode of inheritance and urinalysis findings in Bull Terriers with polycystic kidney disease were assessed by screening 150 clinically normal dogs. The disorder was diagnosed in 39 dogs on the basis of renal ultrasound results and family history of the disease. In equivocal cases confirmation required gross and histopathological renal examination. Necropsy was performed on nine affected dogs and the kidneys from another five affected animals were also examined. Renal cysts were usually bilateral, occurred in cortex and medulla and varied from less than 1 mm to over 2.5 cm in diameter. Cysts were lined by epithelial cells of nephron origin. Abnormal urine sediment and proteinuria were common in affected dogs. The disease appears to be inherited in a highly penetrant autosomal dominant manner.
O'Leary
C A
CA
Section of Pathology, Murdoch University, Western Australia.
Mackay
B M
BM
Malik
R
R
Edmondston
J E
JE
Robinson
W F
WF
Huxtable
C R
CR
D000818:Animals; D001947:Breeding; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000473:pathology; D004285:Dogs; D009517:New South Wales / Q000453:epidemiology; D016891:Polycystic Kidney, Autosomal Dominant / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D015995:Prevalence; D011793:Queensland / Q000453:epidemiology; D014463:Ultrasonography; D016482:Urinalysis / Q000662:veterinary