title: In-Line Proximity Effects in Extended 7-Azanorbornanes. 1. A New Concept for Modifying Effector Group Separation Based on the Control of N-Invertomer Geometry.
abstract: Control of N-substituent geometry in fused 7-azanorbornane systems is based on the dominance of one proximate bridge (sentinel X) over the other (sentinel Y) relative to the N-bridge; the N-inversion equilibrium can effectively be displaced in favor of a single invertomer. This study has used a combination of synthesis, crystallography, and molecular modeling to establish stereostructures.
authors.affiliation: Centre for Molecular Architecture, Central Queensland University, Rockhampton, Queensland, 4702, Australia, and Department of Chemistry, University of Leicester, Leicester, LE1 7RH, U.K.
authors.initials: DN
authors.lastname: Butler
authors.initials: ML
authors.lastname: Hammond
authors.initials: MR
authors.lastname: Johnston
authors.initials: G
authors.lastname: Sun
authors.initials: JR
authors.lastname: Malpass
authors.initials: J
authors.lastname: Fawcett
authors.initials: RN
authors.lastname: Warrener