title: [New derivatives of pantolactonyl N-phthalimido-2-arylpropanoate].
abstract: We present the crystal and molecular structures of two new N-phthalyl-3-amino-2-arylpropionic acid pantolactonyl ester derivatives with 4-fluorophenyl and 3,4-dimethoxyphenyl as the aryl group, 2,3,4,5-tetrahydro-4,4-dimethyl-2-oxofuran-3-yl 3-phthalimido-2-(4-fluorophenyl)propanoate, C23H20FNO6, and 2,3,4,5-tetrahydro-4,4-dimethyl-2-oxofuran-3-yl 3-phthalimido-2-(3,4-dimethoxyphenyl)propanoate ethyl acetate hemisolvate, C25H25NO8.0.5C4H8O2. This structural study confirms the S configuration of the C2 and validates the stereospecificity of our synthesis strategy.
authors.affiliation: Laboratoire des Aminoacides, Peptides et Protéines, Université Montpellier I et II, Faculté de Pharmacie, UMR CNRS 5810, France. rolland@colombes.pharma.univ-montp1.fr
authors.forename: M
authors.initials: M
authors.lastname: Rolland
authors.forename: M
authors.initials: M
authors.lastname: Calmès
authors.forename: F
authors.initials: F
authors.lastname: Escale
authors.forename: J
authors.initials: J
authors.lastname: Martinez
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010797:Phthalimides; D015107:4-Butyrolactone