Inverse relation between plasma G-CSF levels and neutrophil counts in a patient with autoimmune neutropenia treated with G-CSF.
The pharmacokinetic characteristics of granulocyte colony-stimulating factor (G-CSF) appears to be related to the neutrophil count. We report the case of an 81-year-old male with acquired antibody induced neutropenia treated with G-CSF. This produced a rapid increase in the neutrophil count which appeared to be associated with diminished trough plasma G-CSF levels. Our data appears to indicate that mature neutrophils may play a part in the clearance of G-CSF from plasma.
Vlasveld
L T
LT
Department of Internal Medicine and Department of Clinical Chemistry, Diaconessenhuis, Eindhoven, The Netherlands.
Ermens
A A
AA
D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000188:drug therapy; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007519:Isoantigens / Q000097:blood; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D017452:Receptors, IgG / Q000097:blood; D013997:Time Factors
D007519:Isoantigens; D017452:Receptors, IgG; C104384:neutrophil-specific antigen SH; D016179:Granulocyte Colony-Stimulating Factor