New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures.
[reaction: see text] We present two new diffusion-edited NMR experiments, improved DECODES and HETDECODES, that sort the constituents in a mixture by their individual diffusion coefficients. These experiments should allow the partial NMR spectral assignment and cursory structure elucidation of compounds in a complex mixture as an aid in the dereplication of known or nuisance compounds.
Williamson
R T
RT
College of Pharmacy, Oregon State University, Corvallis 97331, USA.
Chapin
E L
EL
Carr
A W
AW
Gilbert
J R
JR
Graupner
P R
PR
Lewer
P
P
McKamey
P
P
Carney
J R
JR
Gerwick
W H
WH
D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification*; D001709:Biotechnology; D000458:Cyanobacteria / Q000737:chemistry; D004058:Diffusion; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*
D001685:Biological Factors; D007306:Insecticides