Cyclin-dependent kinase 5 (Cdk5) associated with Lewy bodies in diffuse Lewy body disease.
We investigated the cyclin-dependent kinase (Cdk) 5 distribution pattern in diffuse Lewy body disease brains using immunohistochemistry. Cdk5 immunoreactivity was detected in both brainstem-type Lewy bodies (LBs) and cortical LBs. The number of Cdk5-positive LBs was less than that of ubiquitin- or alpha-synuclein-positive LBs, and more than that of phosphorylated neurofilament-positive LBs. Immunoelectron microscopy revealed Cdk5-immunolabeled granulo-filamentous components in LBs and LB-related neurites. These data suggest that Cdk5 may be associated with LB formation.
Takahashi
M
M
Department of Psychiatry, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Japan. megnobt@mb.infoweb.ne.jp
Iseki
E
E
Kosaka
K
K
D000368:Aged; D000369:Aged, 80 and over; D001369:Axons / Q000201:enzymology / Q000648:ultrastructure; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000201:enzymology* / Q000648:ultrastructure; D020961:Lewy Body Disease / Q000378:metabolism*; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D009410:Nerve Degeneration / Q000378:metabolism; D013569:Synapses / Q000201:enzymology / Q000648:ultrastructure
D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human; D018844:Cyclin-Dependent Kinases