HIV-associated malignancies in children.
The exact incidence of malignancies in HIV-infected children is not clear; however, an excess of non-Hodgkin's lymphomas (NHLs) and soft tissue tumors (leiomyosarcomas) is evident. The spectrum of diseases is slightly different in children compared to adults. For example, Kaposi's sarcoma (KS), although common in HIV-infected adults, is rare in children in industrialized countries. Preliminary results with brief, dose-intensive chemotherapeutic regimens have been encouraging. Such regimens may be complicated, however, by multiple HIV-associated organ dysfunctions, drug interactions, and infectious complications secondary to severe immunosuppression.
Mueller
B U
BU
Department of Pediatrics, Harvard Medical School, Children's Hospital, Boston, Massachusetts, USA. mueller_b@al.tch.harvard.edu
D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology*; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000453:epidemiology*; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012514:Sarcoma, Kaposi / Q000175:diagnosis / Q000453:epidemiology*