[Drug-resistant bacteria of current topics and their resistance mechanisms--PRSP and BLNAR].
The prevalence of resistant isolates for beta-lactam antibiotics have been rapidly increasing in Streptococcus pneumoniae and Haemophilus influenzae. These strains having resistant elements are called penicillin-resistant S. pneumoniae(PRSP) and beta-lactamase-negative ampicillin-resistant H. influenzae(BLNAR). The mechanism of resistance was identified as the reduction of penicillin-binding proteins(PBPs) affinities as the target of beta-lactams. In PRSP, pbp1a, pbp2x, and pbp2b encoding PBP1A, -2X, and -2B enzymes, respectively, were altered. In contrast, mutations in the ftsI gene encoding PBP3A were only clarified in BLNAR. Characteristics of the resistance caused by PBPs alterations are a low-level resistance that decrease bactericidal action.
Ubukata
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D000668:Ampicillin Resistance; D006193:Haemophilus influenzae / Q000187:drug effects*; D010403:Penicillin Resistance; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis
D001618:beta-Lactamases