Differences in water diffusion and lactate production in two different types of postinfectious encephalopathy.
We compared two different types of postinfectious encephalopathy using magnetic resonance imaging (MRI), including diffusion-weighted images and MR spectroscopy. Acute disseminated encephalomyelitis (ADEM) and acute necrotizing encephalopathy (ANE) showed different distribution of abnormal intensity areas and different diffusion of water measured by diffusion-weighted imaging (DWI). Proton MR spectroscopy (MRS) showed lactate production in both cases, which returned to a normal range; the rate of increased lactate production was much lower in the ANE case. Water diffusion showed a difference in pathophysiological background between the two encephalopathies, but the lactate elevation observed by proton MRS did not correlate with clinical severity.
Harada
M
M
Department of Radiology, School of Medicine, University of Tokushima, Tokushima 770-8503, Japan. masafumi@clin.med.tokushima-u.ac.jp
Hisaoka
S
S
Mori
K
K
Yoneda
K
K
Noda
S
S
Nishitani
H
H
D001834:Body Water; D001923:Brain Chemistry; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D002648:Child; D017352:Echo-Planar Imaging; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications*; D019344:Lactic Acid / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy; D009336:Necrosis
D019344:Lactic Acid