title: Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese.
abstract: To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significant association of the variant with type 1 diabetes or type 2 diabetes in Japanese. Also, there were no significant differences in clinical characteristics with and without the variant. Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese.
authors.affiliation: The Fourth Department of Medicine, Saitama Medical School, 38 Morohongo, Moroyama-machi, Iruma-gun, Saitama, Japan. awata@saitama-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Awata
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: I
authors.initials: I
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Takino
authors.forename: Y
authors.initials: Y
authors.lastname: Kanazawa
authors.forename: S
authors.initials: S
authors.lastname: Katayama
mesh_terms: D000328:Adult; D000483:Alleles; D051792:Basic Helix-Loop-Helix Proteins; D004247:DNA / Q000737:chemistry; D017931:DNA Primers / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016133:Polymerase Chain Reaction; D015534:Trans-Activators / Q000737:chemistry / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D004247:DNA; D017931:DNA Primers; D004268:DNA-Binding Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C093970:NEUROD1 protein, human