[Antioxidant properties and membranotropic effect of certain derivatives of 1,4-dihydropyridine].
Interaction of alpha-tocopherol and 1,4-dihydropyridine with endoplasmic reticulum membranes and model systems, human serum albumin and phospholipid bilayer, was studied using the microcalorimetry and fluorescent probes procedures. Dependence of microviscosity changes in the endoplasmic reticulum membranes on the place of antioxidants localization (protein structures or phospholipid phase) was shown. Increase of membrane structuralization under the influence of 1,4-dihydropyridines blocked their antioxidant action in spontaneous and induced lipid peroxidation.
Gubskiĭ
Iu I
IuI
Institute of Pharmacology and Toxicology of Ukraine Academy of Medical Sciences, Kyiv.
Goriushko
A G
AG
Litvinova
N V
NV
Pirmak
R G
RG
Kruskaia
N M
NM
Shnurko
E V
EV
Sachenko
L G
LG
D000975:Antioxidants / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002151:Calorimetry; D005456:Fluorescent Dyes; D006801:Humans; D007425:Intracellular Membranes / Q000187:drug effects*; D008051:Lipid Bilayers; D015227:Lipid Peroxidation / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D009568:Nitrendipine / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D002121:Calcium Channel Blockers; D005456:Fluorescent Dyes; D008051:Lipid Bilayers; D014810:Vitamin E; D009568:Nitrendipine; D009543:Nifedipine