[The influence of hormones of stress-promoting system on the course of acute ischemic stroke].
Experimental and clinical studies have proved an important role of the reaction of a stress-realizing endocrine system for both a course and an outcome of acute somatic diseases. That is why plasma concentrations of thyroxine (T4), triiodo-thyronine (T3), thyrotropic (TTH) and adrenocorticotropic (ACTH) hormones as well as of renin were measured during the 1-st week of acute ischemic stroke (AIS) in relevant patients for determination of their prognostic significance. 16 patients with hemispheric AIS were examined. A complex clinical biochemical investigation performed in patients with acute disorders of cerebral circulation revealed the presence of the "low T3 syndrome" accompanied by an increase of blood plasma levels of T4 by the 7-th day of the disease as well as an increase of the concentrations of TTH, ACTH and renin on the 2-nd day of the stroke. That reflected the severity of cerebral ischemia. Close correlation observed between the degree of normalization of hormonal concentrations and manifestations of neurologic disorders' regression by the 7-th and the 21-st days gave a good ground to consider these indices as a prognostic criterion for determination of an outcome of the acute period of ischemic stroke.
Skvortsova
V I
VI
Platonova
I A
IA
Ostrovtsev
I V
IV
Zhuravleva
E Iu
EIu
Chigraĭ
Z A
ZA
Efremova
N M
NM
Ogareva
N V
NV
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012083:Renin / Q000097:blood*; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*
D013963:Thyroid Hormones; D000324:Adrenocorticotropic Hormone; D012083:Renin