title: Stimulatory effect of curcumin on osteoclast apoptosis.
abstract: Curcumin is a potent inhibitor of the transcriptional factors activator protein-1 and nuclear factor-kappaB. Since transcriptional factors may play a functional role in the survival of osteoclasts, it was of interest to us to examine the effect of curcumin on osteoclast apoptosis. We observed that curcumin is a potent stimulator of this process in rabbit osteoclasts, as evidenced by morphological changes in nuclei and DNA fragmentation as criteria of apoptosis. The curcumin stimulation of the osteoclast apoptosis was dose-and treatment time-dependent. In addition, curcumin dramatically inhibited osteoclastic bone resorption, supporting our data that curcumin is a potent stimulator of osteoclast apoptosis.
authors.affiliation: Department of Oral Microbiology, Meikai University School of Dentistry, Keyakidai, Sakado, Saitama, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ozaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kawata
authors.forename: S
authors.initials: S
authors.lastname: Amano
authors.forename: S
authors.initials: S
authors.lastname: Hanazawa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D001862:Bone Resorption / Q000517:prevention & control; D003474:Curcumin / Q000494:pharmacology* / Q000627:therapeutic use; D066298:In Vitro Techniques; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects*; D011817:Rabbits
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003474:Curcumin