title: Decrease of HCVRNA after three days of daily interferon treatment is predictive of the virological response at one month.
abstract: Early monitoring of HCVRNA during interferon treatment may allow clinicians to obtain important information that could help them to adopt therapeutic decisions in individual cases. The hepatitis C virus infection is highly dynamic and a daily high dose of IFN may induce a decline of viremia of 95+/-10% of baseline value after 24 to 48 hours of treatment. The importance of this early antiviral efficacy has not been understood. We have measured HCVRNA levels in 47 patients with chronic hepatitis C infection during interferon treatment to study HCVRNA kinetics and evaluate the predictive value of the early decay of viremia on the virological response after one month of treatment. Sixty percent of treated patients showed early virological response (EVR) and it was significantly associated with low HCVRNA levels and a genotype other than 1b. Finally, the absence of an 85% decline in HCVRNA levels after 3 days of treatment observed in 11 out of 45 patients (24%) was an absolute and very early predictor of the absence of EVR in the study population.
authors.affiliation: Department of Clinical Chemistry, O.P. Richiedei, Brescia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Magalini
authors.forename: M
authors.initials: M
authors.lastname: Puoti
authors.forename: V
authors.initials: V
authors.lastname: Putzolu
authors.forename: E
authors.initials: E
authors.lastname: Quiros-Roldan
authors.forename: M A
authors.initials: MA
authors.lastname: Forleo
authors.forename: S
authors.initials: S
authors.lastname: Rossi
authors.forename: S
authors.initials: S
authors.lastname: Zaltron
authors.forename: A
authors.initials: A
authors.lastname: Spinetti
authors.forename: B
authors.initials: B
authors.lastname: Zanini
authors.forename: A
authors.initials: A
authors.lastname: Zonaro
authors.forename: R
authors.initials: R
authors.lastname: Solfrini
authors.forename: G
authors.initials: G
authors.lastname: Carosi
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000175:diagnosis / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000032:analysis*; D012680:Sensitivity and Specificity; D014766:Viremia / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D007372:Interferons