Nitrogen bridgehead compounds, facile synthesis of bioactive cyanopyrimido[1,2-a]pyrimidinones.
Synthesis of some new cyanopyrimido[1,2-a]pyrimidinones 5-22 have been achieved via interaction of 2-amino-6-anisyl-5-cyano-4(3H)-pyrimidinone (1) with some heterocycles having a vicinal chloroester, chlorocyano or mercaptocyano group, dimethyl acetylenedicarboxylate, active methylene compounds, ethyl 2-acetyl-3-anisylpropenoate, ethyl 3-aryl-3-cyanopropenoates, ethyl 2-cyano-3-ethoxyacrylate and some enones or enals. Some of the isolated products were subjected to biological screening tests.
Abdel-Megid
M
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Chemistry Department, Faculty of Education, Ain-Shams University, Roxy, Cairo, Egypt.
D020095:Absidia / Q000187:drug effects / Q000201:enzymology; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D013268:Stimulation, Chemical; D001617:beta-Glucosidase / Q000187:drug effects / Q000378:metabolism*
D011744:Pyrimidinones; D001617:beta-Glucosidase