title: [Granulocyte colony-stimulating factor in the treatment of febrile neutropenia].
abstract: OBJECTIVE
  To determine whether granulocyte colony-stimulating factor (G-CSF) used in addition to antibiotic therapy, in patients with chemotherapy-induced febrile neutropenia shortens the period of fever, neutropenia and hospitalization.
  
  
  METHODS
  The study was prospective. Patients with lymphoblastic acute leukemia (LAL) were included. They received intensive chemotherapy of induction, intensification, or consolidation. At random, a group received amikacin-ceftriaxone; if no had response after 3 days, we added vancomicin and, after 7 days, amphotericin. The other group received in addition these antibiotics, granulocyte colony-stimulating factor.
  
  
  RESULTS
  The groups were comparable in the magnitude of the initial neutropenia (< 0.5 x 10(9)/L), site of the infection, chemotherapy received germs isolated, age, and sex. The patients of the group that received FEC-G were cured in the course of 3.1 days; in the group without FEC-G, this occurred in 7.2 days (p = 0.0001). At the end of the infectious episode, the number of neutrophils, in the group with FEC-G, was of 1.9 x 10(9)/L versus 0.7 x 10(9)/L (p = 0.0009). The mortality was of one and two cases (p = 0.46). The global mortality was 7.5%.
  
  
  CONCLUSIONS
  The addition of FEC-G to the treatment with antibiotics, in febrile neutropenia, decreases duration of days with fever, hospitalization and neutropenia. However, the frequency of cure is not augmented.
authors.affiliation: Servicio de Hematología, CMN 20 de Noviembre, ISSTE, México, DF.
authors.forename: M A
authors.initials: MA
authors.lastname: López-Hernández
authors.forename: R
authors.initials: R
authors.lastname: Jiménez-Alvarado
authors.forename: R
authors.initials: R
authors.lastname: Borbolla-Escoboza
authors.forename: J
authors.initials: J
authors.lastname: de Diego Flores-Chapa
authors.forename: M
authors.initials: M
authors.lastname: Alvarado-Ibarra
authors.forename: M
authors.initials: M
authors.lastname: González-Avante
authors.forename: M E
authors.initials: ME
authors.lastname: Trueba-Chrysti
authors.forename: I
authors.initials: I
authors.lastname: Anaya-Cuéllar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D005260:Female; D005334:Fever / Q000188:drug therapy* / Q000209:etiology; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy; D011446:Prospective Studies; D011994:Recombinant Proteins; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim