title: Iatrogenic arterial spasm relieved by intraarterial mannitol infusion.
abstract: Catheter placement for blood brain-barrier disruption and enhanced chemotherapy delivery can sometimes trigger arterial spasm of moderate-to-severe degree. A slow infusion of a small quantity of intraarterially administered mannitol (10 mL of 25% mannitol) was evaluated as a means to obtain a rapid resolution of catheter placement-induced spasm. We prospectively report 12 consecutive cases of blood brain-barrier disruption among patients who developed catheter placement-induced spasm that was treated by this means without side effects, resulting in rapid resolution of spasm.
authors.affiliation: Department of Neurology, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: D
authors.initials: D
authors.lastname: Fortin
authors.forename: E
authors.initials: E
authors.lastname: Osztie
authors.forename: E A
authors.initials: EA
authors.lastname: Neuwelt
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001932:Brain Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D002533:Cerebral Angiography; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007049:Iatrogenic Disease; D007261:Infusions, Intra-Arterial; D008353:Mannitol / Q000008:administration & dosage*; D011446:Prospective Studies; D014664:Vasodilation / Q000187:drug effects; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D008353:Mannitol