Postantibiotic suppression of growth of erythromycin A-susceptible and -resistant gram-positive bacteria by the ketolides telithromycin (HMR 3647) and HMR 3004.
We investigated the in vitro postantibiotic effects (PAEs) of the ketolides telithromycin (HMR 3647) and HMR 3004 and analyzed the results using the sigmoid E(max) model. Mean maximum telithromycin PAEs against erythromycin A-susceptible strains of Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae were 3. 7, 8.9, and 9.7 h, respectively, while maximum PAEs for erythromycin A-resistant strains were much shorter. Mean maximum HMR 3004 PAEs were 3.2 to 4.4 h for all species.
Munckhof
W J
WJ
Department of Infectious Diseases and Clinical Epidemiology, Monash Medical Centre, Victoria 3168, Australia. munckhof@health.qld.gov.au
Borlace
G
G
Turnidge
J D
JD
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D048628:Ketolides; D018942:Macrolides; D013210:Staphylococcus / Q000187:drug effects* / Q000254:growth & development*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C105420:RU 64004; D004917:Erythromycin; C106791:telithromycin