Isatin (Indole-2, 3-dione) inhibits natriuretic peptide-induced hyperthermia in rats.
The effects of an endogenous indole, isatin (indole-2, 3-dione), on the hyperthermia induced by atrial natriuretic peptide (ANP-28), brain natriuretic peptide (BNP-32), and C-type natriuretic peptide (CNP-22) were investigated in rats. Intracerebroventricular administration of each peptide in a dose of 1 microg caused elevations in colon temperature 30 and 60 min after injection. An intraperitoneal (i.p.) injection of isatin (50 mg/kg) abolished the natriuretic peptide-induced hyperthermia. These data reinforce the possible involvement of natriuretic peptides in thermoregulatory processes in the central nervous system, and suggest that isatin might counteract their hyperthermic effect in vivo.
Pataki
I
I
Department of Pathophysiology, MTA-SZOTE Neurohumoral Research Group, Albert Szent-Györgyi Medical University, Semmelweis u.1, P.O. Box 531, H-6701, Szeged, Hungary.
Adamik
A
A
Telegdy
G
G
D000704:Analysis of Variance; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007510:Isatin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D020097:Natriuretic Peptide, Brain; D020098:Natriuretic Peptide, C-Type / Q000008:administration & dosage / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain; C076910:brain natriuretic peptide, porcine; D020098:Natriuretic Peptide, C-Type; D007510:Isatin; D009320:Atrial Natriuretic Factor