[Will the revolutionary knowledge of apoptosis play an important role in medicine?].
Apoptosis is a phenomenon of fundamental importance in embryonal development and the homeostatic regulation of mature tissue. We review the present knowledge on apoptosis and the evidence that apoptosis may play a role in the pathogenesis of human disease. As examples we discuss its role in cancer, ischemic diseases, heart failure and neurodegenerative diseases.
Løberg
E M
EM
Patologisk anatomisk avdeling Ullevål sykehus, Oslo.
Lømo
J
J
Maehlen
J
J
D017209:Apoptosis; D004194:Disease; D006333:Heart Failure / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009369:Neoplasms / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology