title: Nonsequence-specific DNA recognition: a structural perspective.
abstract: Chromosomal proteins that form essential architectural components of chromatin bind and bend DNA with an intrinsic low degree of sequence preference. Comparisons made between two recently determined structures of high mobility group (HMG) protein-DNA complexes and other nonsequence-specific protein-DNA complexes reveal the structural basis of this important mode of DNA binding.
authors.affiliation: Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: F V
authors.initials: FV
authors.lastname: Murphy
authors.forename: M E
authors.initials: ME
authors.lastname: Churchill
mesh_terms: D019843:Archaeal Proteins / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D006609:High Mobility Group Proteins / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000378:metabolism; D011487:Protein Conformation; D014867:Water
chemical_list: D019843:Archaeal Proteins; D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D009707:Nucleosomes; D014867:Water; D004247:DNA