Imipenem but not meropenem induces convulsions in DBA/2 mice, unrelated to cerebrospinal fluid concentrations.
Imipenem and meropenem CSF diffusion was comparable in DBA/2 mice but only imipenem induced convulsions, not related to CSF concentration.
Dupuis
A
A
Laboratoire de pharmacie galénique et biopharmacie, faculté de médecine & pharmacie, Poitiers, France.
Pariat
C
C
Courtois
P
P
Couet
W
W
Bouquet
S
S
D000818:Animals; D015377:Cilastatin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D015378:Imipenem / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008297:Male; D000077731:Meropenem; D051379:Mice; D008811:Mice, Inbred DBA; D011480:Protease Inhibitors / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced*; D013845:Thienamycins / Q000134:cerebrospinal fluid / Q000494:pharmacology*
D011480:Protease Inhibitors; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D000077731:Meropenem