Low protein diets delay end-stage renal disease in non diabetic adults with chronic renal failure.
BACKGROUND
Since more than fifty years, low protein diets are proposed to patients with kidney failure. However, the effects of these diets in preventing severe renal failure and the need for maintenance dialysis is still controversial.


OBJECTIVE
To determine the efficacy of low protein diets in delaying the need to start maintenance dialysis.


METHODS
Medline and Embase search from January 1966 through June 1999. Congress abstracts (American Society of Nephrology since 1990, European Dialysis Transplant Association since1985, International Society of Nephrology since 1987). Direct contacts with investigators.


METHODS
Randomised trials comparing two different levels of protein intake in adult patients suffering from moderate to severe renal failure, followed for at least one year. Exclusion of patients with diabetic nephropathy.


METHODS
Seven trials selected over 40 studies since 1975. A total of 1494 patients analysed, 753 receiving a reduced protein intake and 741 a larger protein intake. Collection of the number of "renal death" being the need for starting dialysis, the death of a patient or the transplantation of a kidney during the trials.


RESULTS
242 renal deaths were recorded, 101 in the low protein diet and 141 in the larger protein diet group, giving an odds ratio of low protein to control of 0.62 with a 95% confidence interval of 0.46 to 0.83 (p<0.001, Peto odds ratio). To spare one extra renal death, 17 patients need to be treated (NNT) with a low protein diet for approximately two years.


CONCLUSIONS
Reducing protein intake in patients with chronic renal failure do reduce the occurence of renal death by about 40% as compared with larger or unrestricted protein intake and therefore should be warmly recommended to patients. The optimal level of protein intake cannot be deduced from the present work. However, based on other nutritional studies perfomed in patients having chronic renal failure, we recommend a protein intake of 0.6 g/kg/day and an energy intake no less than 35 kcal/kg/day. Skilled dietitian survey should be offered to closely monitor these values and the patient's nutritional status.
Fouque
D
D
Dept of Nephrology and Hypertension, Hôpital Edouard HERRIOT, Place d'Arsonval, Lyon, France, 69437 CEDEX 03. denis.fouque@chu-lyon.fr
Wang
P
P
Laville
M
M
Boissel
J P
JP
D000328:Adult; D018753:Diet, Protein-Restricted; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000178:diet therapy* / Q000209:etiology / Q000517:prevention & control*