Neonatal sympathectomy reduces adult blood pressure and cardiovascular pathology in Y chromosome consomic rats.
The hypothesis was tested that the sympathetic nervous system (SNS) developmentally influences circulating testosterone (T), systolic blood pressure (SBP) and cardio-renal pathology in SHR/y animals. A sympathoplegic drug, guanethidine, and an antibody to nerve growth factor were administered to WKY and borderline hypertensive SHR/y male rats (n = 20/group) for the first 3 weeks of life; control groups (n = 20/group) received saline. SBP, serum T and luteinizing hormone (LH) were measured. SBP in the WKY and SHR/y sympathectomy (sympx) groups decreased 10mmHg (p < 0.001) and 50mmHg (p < 0.001), respectively, when compared to their control groups. Serum T levels in the sympx WKY group were lower (p < 0.01) than those in controls, and the rise of T typically observed in SHR/y from weeks 6-8 was delayed in the sympx SHR/y group, similar to the pattern in WKY. Serum LH levels were increased in the sympx WKY group, but not in the SHR/y group. Sympx caused a greater reduction in renal glomerular changes (p < 0.01), coronary artery collagen deposition (p < 0.01) and myocardial fibrosis (p < 0.01) in SHR/y than WKY rats. In conclusion, the SHR Y chromosome has a locus that enhances SNS activity, which can raise SBP and result in renal and cardiovascular tissue damage.
Wiley
D H
DH
Department of Biology, University of Akron, Ohio 44325-3908, USA.
Dunphy
G
G
Daneshvar
H
H
Salisbury
R
R
Neeki
M
M
Ely
D L
DL
D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D002319:Cardiovascular System / Q000473:pathology; D005260:Female; D006973:Hypertension / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013562:Sympathectomy; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013739:Testosterone / Q000097:blood; D014018:Tissue Distribution; D014998:Y Chromosome / Q000235:genetics*
D013739:Testosterone; D007986:Luteinizing Hormone; D009638:Norepinephrine