Protein phosphatase 2A: a definite player in viral and parasitic regulation.
Cells use phosphorylation/dephosphorylation mechanisms to regulate the activity of several proteins required to transmit information from the cell surface to the nucleus. Recent studies have significantly increased our knowledge regarding the structure/function of one major regulator of cell phosphorylation: protein phosphatase 2A (PP2A). This review will discuss the role of PP2A in virology and parasitology.
Garcia
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Laboratoire de signalisation immuno-parasitaire, département d'immunologie, Institut Pasteur, Paris, France.
Cayla
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Sontag
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D000818:Animals; D056890:Eukaryota / Q000254:growth & development / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism; D051744:Protein Kinase C-epsilon; D054648:Protein Phosphatase 2; D015398:Signal Transduction; D014780:Viruses / Q000254:growth & development / Q000378:metabolism*
D007527:Isoenzymes; C497255:PRKCE protein, human; D011493:Protein Kinase C; D051744:Protein Kinase C-epsilon; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2