title: A population-based case-control teratologic study of furazidine, a nitrofuran-derivative treatment during pregnancy.
abstract: OBJECTIVE
  To study human teratogenic potential of furazidine treatment during pregnancy.
  
  
  METHODS
  Pair analysis of cases with congenital abnormalities and matched population controls.
  
  
  METHODS
  The Hungarian Case-Control Surveillance of Congenital Abnormalities.
  
  
  METHODS
  38,151 pregnant women who had newborn infants without any defects (population control group) and 22,865 pregnant women who had newborns or fetuses with congenital abnormalities between 1980 and 1996.
  
  
  RESULTS
  In the case group, 157 (0.7%) and in the control group, 254 (0.7%) pregnant women were treated with furazidine. The case-control pair analysis did not indicate a teratogenic potential of furazidine use during the second to third months of gestation, i.e. in the critical period for major congenital abnormalities.
  
  
  CONCLUSIONS
  Treatment with furazidine during pregnancy did not show teratogenic risk to the fetus.
authors.affiliation: Department of Human Genetics and Teratology, National Center for Epidemiology, Budapest, Hungary.
authors.forename: A E
authors.initials: AE
authors.lastname: Czeizel
authors.forename: M
authors.initials: M
authors.lastname: Rockenbauer
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
authors.forename: J
authors.initials: J
authors.lastname: Olsen
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D016022:Case-Control Studies; D005260:Female; D005661:Furagin / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000892:Anti-Infective Agents, Urinary; D005661:Furagin