title: Multivessel coronary thrombosis, acute myocardial infarction, and no reflow in a patient with essential thrombocythaemia.
abstract: Essential thrombocythaemia (ET) has been reported rarely to cause coronary thrombosis, but the management is still undefined. A 63 year old woman with multivessel coronary thrombosis, acute myocardial infarction (MI), and no reflow in reperfused coronary artery in association with ET is presented. The patient's platelet count was only moderately raised at the onset of MI, but peripheral blood smear and bone marrow evaluation revealed clumping giant platelets and numerous large hyperploid megakaryocytes. Long term prophylaxis with antiplatelet agents in patients with ET is recommended, even if the platelet count is not largely raised. Cytoreductive treatment may also be effective for secondary prevention when thrombotic complications occur.
authors.affiliation: Division of Cardiology, Third Department of Internal Medicine, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu 431-3192, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Terada
authors.forename: H
authors.initials: H
authors.lastname: Satoh
authors.forename: A
authors.initials: A
authors.lastname: Uehara
mesh_terms: D003328:Coronary Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006801:Humans; D008533:Megakaryocytes / Q000473:pathology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy; D015425:Myocardial Reperfusion; D010974:Platelet Aggregation; D011859:Radiography; D013921:Thrombocytopenia / Q000150:complications* / Q000000981:diagnostic imaging / Q000628:therapy