Cytogenetics of epithelial hyperplasias of the human breast.
Generally, benign breast lesions behave like innocuous and limited proliferations; however, sometimes they can represent precancerous pathologies. The cytogenetic analysis of five mammary epithelial hyperplasias is reported. Four cases had clonal chromosome alterations. All of the cases presented a modal number of 46 chromosomes. Chromosome 9 monosomies and chromosome 1 deletions were common in these benign tumors. The study of benign proliferations of the breast may reveal a possible relationship between chromosomal alterations and the conditions of the tissue.
Burbano
R R
RR
Departamento de Genética da Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo, Belém-Pará, Brazil.
Medeiros
A
A
de Amorim
M I
MI
Lima
E M
EM
Mello
A
A
Neto
J B
JB
Casartelli
C
C
D001941:Breast Diseases / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007621:Karyotyping