title: An efficient synthesis of pyrimidines from beta-amino alcohols.
abstract: [reaction: see text] Pyrimidinones 3 were chemoselectively reduced by using metal-catalyzed hydrogenation and stereoselectively substituted by various nucleophiles. Starting from beta-amino alcohols 1, the overall process allows efficient access to substituted pyrimidines 4 and 6.
authors.affiliation: Laboratoire de Synthèse Asymétrique UMR 7611, Université P. et M. Curie, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Agami
authors.forename: L
authors.initials: L
authors.lastname: Dechoux
authors.forename: M
authors.initials: M
authors.lastname: Melaimi
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis*
chemical_list: D000605:Amino Alcohols; D011743:Pyrimidines