Review article: the stages of gastrointestinal carcinogenesis--application of rodent models to human disease.
The development of gastrointestinal cancer in humans and animals occurs through a consecutive series of stages termed initiation, promotion and progression. The characterization of each of these stages has been elucidated in several model systems as well as in human neoplasms. Both single, putatively initiated cells and preneoplastic foci have been identified by marker protein differences as well as by mutational changes. The promotion stage involves the clonal expansion of single initiated cells. Such expansion can be rapidly reversed by a variety of means, of which acute fasting (as exemplified in rat hepatocarcinogenesis) is among the most rapid and efficient. This reversal involves a selective apoptosis of preneoplastic cells and preneoplastic lesions, associated with a marked increase in expression of the proto-oncogene c-myc. Transition of cells from the stage of promotion to that of progression initially involves specific karyotypic alterations, as noted in both the rat liver model and human colon carcinogenesis. In the former, the transition appears to be associated with enhanced expression of the H119 imprinted putative tumour suppressor gene. Thus, the use of model systems may be applied directly to the human circumstance, increasing the potential both for rational prevention of gastrointestinal neoplasia and for new approaches to the therapy of neoplastic disease in the progression stage.
Pitot
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HC
McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA.
Hikita
H
H
Dragan
Y
Y
Sargent
L
L
Haas
M
M
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002999:Clone Cells / Q000502:physiology; D003110:Colonic Neoplasms / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D018450:Disease Progression; D005770:Gastrointestinal Neoplasms / Q000235:genetics / Q000473:pathology*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D016259:Genes, myc / Q000502:physiology; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000473:pathology; D051379:Mice; D009367:Neoplasm Staging; D000090063:Proto-Oncogene Mas; D051381:Rats