title: The alpha 1a and alpha 1b-adrenergic receptor subtypes: molecular mechanisms of receptor activation and of drug action.
abstract: In this chapter we summarize some aspects of the structure-functional relationship of the alpha 1a and alpha 1b-adrenergic receptor subtypes related to the receptor activation process as well as the effect of different alpha-blockers on the constitutive activity of the receptor. Molecular modeling of the alpha 1a and alpha 1b-adrenergic receptor subtypes and computational simulation of receptor dynamics were useful to interpret the experimental findings derived from site directed mutagenesis studies.
authors.affiliation: Institut de Pharmacologie et Toxicologie, Université de Lausanne, Faculté de Médecine, Switzerland. susanna.cotecchia@ipharm.unil.ch
authors.forename: S
authors.initials: S
authors.lastname: Cotecchia
authors.forename: O
authors.initials: O
authors.lastname: Rossier
authors.forename: F
authors.initials: F
authors.lastname: Fanelli
authors.forename: A
authors.initials: A
authors.lastname: Leonardi
authors.forename: P G
authors.initials: PG
authors.lastname: De Benedetti
mesh_terms: D000818:Animals; D006801:Humans; D018340:Receptors, Adrenergic, alpha-1 / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism
chemical_list: C547713:ADRA1A protein, human; C547716:ADRA1B protein, human; D018340:Receptors, Adrenergic, alpha-1