[Coagulation/fibrinolysis disorders in the elderly].
To establish reference intervals for the interpretation of hemostatic tests in the elderly, 11 hemostatic tests were performed on 120 elderly individuals(26 males and 94 females) aged 78.6 years in average. The subjects lived in hostel for the elderly, walked without assistance, and were independent in activities in daily living. In 25.8% to 93.3% of the subjects, the results of the tests, except for prothrombin time and thrombin-antithrombin III complex, deviated from reference intervals obtained from young healthy subjects. This suggests the necessity of setting up reference intervals for the elderly. Fibrinolysis was more activated than coagulation, although coagulation had been considered to be more activated because thrombosis is common in the elderly. Wilcoxon test on the test values of the early elderly(65 to 74 years of age) and late elderly(75 to 92 years of age) as well as the correlation coefficient for age and test values revealed that separate reference intervals for antithrombin III, protein C, D-dimer, and thrombomodulin should be established for the early elderly(65 to 74 years) and late elderly(75 years or over). Our proposed reference intervals for the elderly are appropriate for the diagnosis of disseminated intravascular coagulation.
Deguchi
A
A
Oyamada Memorial Spa Hospital, Yokkaichi.
Wada
H
H
Shiku
H
H
Hamaguchi
H
H
Kawamura
Y
Y
D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D001780:Blood Coagulation Tests / Q000592:standards*; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis; D005260:Female; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D012016:Reference Values