Amphidinolide T, novel 19-membered macrolide from marine dinoflagellate Amphidinium sp.
A novel 19-membered macrolide, amphidinolide T (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated on the basis of spectroscopic data. Relative stereochemistry at C-7, C-8, and C-10 was deduced from the NOESY correlations, while absolute configurations at C-2, C-13, C-14, and C-18 were assigned on the basis of NMR data of the MTPA esters of 1 and those of degradation products of 1.
Tsuda
M
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Endo
T
T
Kobayashi
J
J
D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000302:isolation & purification; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification; D004141:Dinoflagellida / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D015394:Molecular Structure; D000097442:Amphidinolides
D019086:Bridged Bicyclo Compounds, Heterocyclic; D003603:Cytotoxins; D007783:Lactones; D018942:Macrolides; C414522:amphidinolide T; D000097442:Amphidinolides