title: Solubilization of substituted indole compounds by beta-cyclodextrin in water.
abstract: The solubilization of four pairs of substituted indole compounds (SICs) by beta-cyclodextrin (beta-CD) in water was investigated. The results show that 1,2,3,4-tetrahydrocarbazole and N-methyl-1,2,3,4-tetrahydrocarbazole form 1:1 inclusion complexes with beta-CD, while the other six SICs form 1:2 inclusion complexes, respectively. To each pair of SICs with similar structures, the differences between their solubilization in beta-CD/water solutions has been explained by the difference of their contact area within the beta-CD cavity, the difference of their molecule polarity, or the presence of hydrogen bond between SIC molecule and beta-CD molecule.
authors.affiliation: Pollution Control and Resources Reuse National Key Laboratory, Department of Environmental Science and Engineering, Nanjing University, People's Republic of China. ecls@nju.edu.cn
authors.forename: J
authors.initials: J
authors.lastname: Cao
authors.forename: C
authors.initials: C
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Han
mesh_terms: D002227:Carbazoles / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006860:Hydrogen Bonding; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D012995:Solubility / Q000187:drug effects; D014867:Water / Q000737:chemistry*; D047392:beta-Cyclodextrins
chemical_list: D002227:Carbazoles; D003505:Cyclodextrins; D007211:Indoles; C409926:N-methyl-1,2,3,4-tetrahydrocarbazole; D047392:beta-Cyclodextrins; D014867:Water; C409925:1,2,3,4-tetrahydrocarbazole; C031215:betadex