Tuberin expression in ganglioglioma.
The expression of tuberin in neurosurgically resected gangliogliomas was investigated. Neither neoplastic astrocytes nor abnormal, multipolar large neurons showed immunoreactivity for tuberin. The reduced immuno-histochemical staining for tuberin was consistent with the reduction observed in Western blot analysis. Eosinophilic granular bodies and Rosenthal fibers were strongly immunoreactive for tuberin. The accumulation of tuberin in astrocytes with intracellular degenerative changes suggests increased expression in reactive cells, and perhaps a broader role for tuberin in central nervous system disease.
Arai
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Department of Clinical Laboratory, Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, Tokyo, Japan.
Ackerley
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CA
Becker
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LE
D000293:Adolescent; D000328:Adult; D000943:Antigens, Differentiation / Q000378:metabolism; D001253:Astrocytes / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D001254:Astrocytoma / Q000378:metabolism* / Q000648:ultrastructure; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004727:Endothelium / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D018303:Ganglioglioma / Q000378:metabolism* / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000096:biosynthesis; D005911:Gliosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009474:Neurons / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D012097:Repressor Proteins / Q000096:biosynthesis*; D012189:Retrospective Studies; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D000943:Antigens, Differentiation; D005904:Glial Fibrillary Acidic Protein; D012097:Repressor Proteins; C000624653:TSC2 protein, human; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins