title: Synaptic plasticity and dynamic modulation of the postsynaptic membrane.
abstract: The biochemical composition of the postsynaptic membrane and the structure of dendritic spines may be rapidly modulated by synaptic activity. Here we review these findings, discuss their implications for long-term potentiation (LTP) and long-term depression (LTD) and propose a model of sequentially occurring expression mechanisms.
authors.affiliation: Department of Pharmacology (APSIC), CMU, 1, Rue Michel-Servet, Université de Genève, 1211 Geneva 4, Switzerland. christian.luscher@medecine.unige.ch
authors.forename: C
authors.initials: C
authors.lastname: Lüscher
authors.forename: R A
authors.initials: RA
authors.lastname: Nicoll
authors.forename: R C
authors.initials: RC
authors.lastname: Malenka
authors.forename: D
authors.initials: D
authors.lastname: Muller
mesh_terms: D000818:Animals; D048429:Cell Size; D003712:Dendrites / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000502:physiology*; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009433:Neural Inhibition / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D011554:Pseudopodia / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D013569:Synapses / Q000378:metabolism*; D013570:Synaptic Membranes / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D018091:Receptors, AMPA