Total pancreatico-duodenal transplantation with portal venous drainage: metabolic assessments in diabetic rats.
A perfect metabolic correction of diabetes is essential to completely eradicate long-term chronic complications. Only a total pancreatic graft with portal venous drainage enables such an achievement. Isogenic Lewis rats were used for donors, recipients and controls. Pancreatico-duodenal transplantation was either heterotopic with systemic venous drainage (n = 12) or paratopic with portal drainage (n = 11). All animals were regularly monitored for non-fasting plasma glucose and insulin. Both techniques promptly restored the non-fasting plasma glucose to normal values (p<0.003). Normo-insulinemia (47.4+/-6.4 microU/ml) was obtained in the paratopic group, while the heterotopic group showed hyperinsulinism (132.0+/-15.2 microU/ml). Perfect metabolic control justifies the additional technical difficulties of total paratopic pancreatic transplantation with portal venous drainage.
Elian
N
N
Department of Surgery and Diabetic Research Unit, Laënnec Hospital, University Denis Diderot-Paris 7, Paris, France.
Carnot
F
F
Bailbé
D
D
Cugnenc
P
P
Altman
J J
JJ
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000503:physiopathology / Q000601:surgery*; D004386:Duodenum / Q000098:blood supply / Q000637:transplantation*; D005260:Female; D007328:Insulin / Q000097:blood; D010179:Pancreas / Q000098:blood supply*; D016035:Pancreas Transplantation; D011169:Portal Vein / Q000503:physiopathology*; D011184:Postoperative Period; D051381:Rats; D011917:Rats, Inbred Lew; D016042:Transplantation, Heterotopic
D001786:Blood Glucose; D007328:Insulin