Red cells I: inherited anaemias.
Examination of the genetic mechanisms underlying the thalassaemias has led to a clearer understanding of the control of eukaryotic genes in general. Inherited disorders of haemoglobin synthesis are an important cause worldwide of morbidity and mortality, and place a large burden on patients, families, and ultimately communities. The haemoglobin disorders can be controlled, by counselling and prenatal diagnosis. Treatment is usually symptomatic, though bone-marrow transplantation for beta-thalassaemia may be successful in suitable patients.
Weatherall
D J
DJ
Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK.
Provan
A B
AB
D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D004920:Erythropoiesis; D006453:Hemoglobinopathies / Q000235:genetics*; D006454:Hemoglobins / Q000502:physiology; D006801:Humans; D013789:Thalassemia / Q000235:genetics*
D006454:Hemoglobins