Genetic and environmental contributions.
There is a remarkable variability in insulin action in humans. Depending upon the definition of the insulin resistance syndrome, different inheritability/environmental influences on insulin action are reported. The environmental contributions to insulin resistance appear to account for approximately 50% of this syndrome. Obese and sedentary insulin-resistant individuals can see dramatic improvement in insulin sensitivity with weight reduction and fitness training. The degree to which obesity is determined by genetic influences will have a substantial impact on insulin resistance in the Western populations. Familial components also appear to account for approximately 50% of the variation and insulin action (as commonly defined by glucose metabolic effects).
Jensen
M D
MD
Mayo Clinic, Rochester, MN 55905, USA.
D016000:Cluster Analysis; D004777:Environment; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology*; D007333:Insulin Resistance / Q000235:genetics*; D009765:Obesity / Q000150:complications*
D007328:Insulin