Pediatric renal cell carcinomas: where do they fit in the new histologic classification of renal cell carcinoma?
Genetic, immunohistochemical, and histologic data has led to the reclassification of renal cell carcinoma in the last decade. Recent studies suggest that renal cell carcinomas in children and young adults may represent a distinct group of tumors. These tumors have unique genetic findings (most commonly t(x;1)(p11:q21)), a predominantly papillary architecture, numerous calcifications, granular cytoplasm, and a possible relationship with neuroblastoma.
Renshaw
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Department of Pathology, Baptist Hospital of Miami, Florida, USA.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000473:pathology; D015415:Biomarkers; D002292:Carcinoma, Renal Cell / Q000145:classification / Q000235:genetics / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007621:Karyotyping; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*; D018396:Mucin-1 / Q000032:analysis; D009447:Neuroblastoma / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D015415:Biomarkers; C400901:CAM 5.2 antigen; D018396:Mucin-1; D014746:Vimentin; D007633:Keratins