title: Therapeutic use of chemokines.
abstract: Chemokines are involved in a number of pathological processes, and therefore represent important targets. However, it has also become apparent that chemokines have exciting therapeutic applications in inflammatory, infectious and cancer-related diseases. The following review will highlight the application of novel therapies including viral-encoded, recombinant, and genetically engineered chemokines to a number of diseases or disorders. Advances in the application of novel chemokine delivery procedures both at the research bench and the clinical bedside will also be discussed. Overall, the utilization of chemokines to prevent and treat disease has tremendous potential.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. hogaboam@path.med.umich.edu
authors.forename: C M
authors.initials: CM
authors.lastname: Hogaboam
authors.forename: C
authors.initials: C
authors.lastname: Bone-Larson
authors.forename: A
authors.initials: A
authors.lastname: Matsukawa
authors.forename: M L
authors.initials: ML
authors.lastname: Steinhauser
authors.forename: K
authors.initials: K
authors.lastname: Blease
authors.forename: N W
authors.initials: NW
authors.lastname: Lukacs
authors.forename: S L
authors.initials: SL
authors.lastname: Kunkel
mesh_terms: D000818:Animals; D018925:Chemokines / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans
chemical_list: D018925:Chemokines