title: Reduced uterine and ovarian size in adolescent girls born small for gestational age.
abstract: Reduced fetal growth is known to be associated with a reduced ovarian fraction of primordial follicles, with ovarian hyperandrogenism and anovulation in late adolescence. In this study, we examined whether adolescent girls born small for gestational age also present an abnormality in uterine or ovarian size. Standardized ultrasound measurements of the internal genitalia were performed in 36 healthy post-menarcheal girls (mean age 14 y) born with a size that was either appropriate for gestational age (AGA) or small (SGA), birth weight averaging 0.1 and -3.0 SD, respectively; clinical and endocrine characteristics were documented concomitantly. Compared with AGA girls, the SGA girls had a smaller uterus (mean difference of 20%; p < 0.006) and a reduced ovarian volume (mean difference of 38%; p < 0.0002). In conclusion, the gynecological correlates of prenatal growth restriction are herewith extended to include a reduced size of the uterus and the ovaries.
authors.affiliation: Endocrinology Unit, Hospital Sant Joan de Déu, University of Barcelona, Esplugues, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Ibáñez
authors.forename: N
authors.initials: N
authors.lastname: Potau
authors.forename: G
authors.initials: G
authors.lastname: Enriquez
authors.forename: F
authors.initials: F
authors.lastname: de Zegher
mesh_terms: D000293:Adolescent; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000254:growth & development*; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography; D014564:Urogenital Abnormalities / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014599:Uterus / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone