[The immunity characteristics of men with gastric and duodenal peptic ulcer associated with Helicobacter pylori].
In males with peptic ulcer of the stomach and the duodenum, associated with H. pylori, the population and subpopulation spectrum of peripheral blood lymphocytes was studied by the method of CD typing with the use of monoclonal antibodies manufactured by the Research Institute "Preparat" (Nizhny Novgorod, Russia). The study revealed the development of disturbances in the amount of populations and subpopulations of peripheral blood lymphocytes, accompanied by a decrease in the absolute number of T lymphocytes (CD3, CD7), T helpers (CD4), T cytotoxic lymphocytes (CD8), B lymphocytes (CD22) and the ratio of CD4/CD8 cells. A decrease in the amount of IgA, IgG, the key complement components C1, C3, C5 was established. In peptic ulcer the immunological characteristics of gastric juice were found to essentially differ from those of saliva by a lower content of mucin, IgA and a higher content of SIgA and IgM in gastric secretions, which may form prerequisites for the colonization of the gastric mucosa by H. pylori.
Smagina
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NV
State Medical Academy, Chelyabinsk, Russia.
D000328:Adult; D000917:Antibody Formation; D015703:Antigens, CD / Q000276:immunology; D001706:Biopsy; D003165:Complement System Proteins / Q000032:analysis; D004381:Duodenal Ulcer / Q000276:immunology*; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000276:immunology / Q000473:pathology; D013276:Stomach Ulcer / Q000276:immunology*
D015703:Antigens, CD; D007136:Immunoglobulins; D003165:Complement System Proteins