title: Tea tree oil: a systematic review of randomized clinical trials.
abstract: OBJECTIVE
  Tea tree oil (TTO) is immensely popular for various topical applications. In vitro studies have repeatedly demonstrated that it has antibiotic activity. This article is an attempt to systematically review the evidence from randomised clinical trials for or against effectiveness of external TTO in dermatological conditions.
  
  
  METHODS
  Six electronic databases were searched. Methodological quality was assessed by Jadad score. Data were extracted and validated in a standardised fashion by two independent reviewers.
  
  
  RESULTS
  Only 4 trials were located. They suggest that TTO may be effective as a treatment of acne and fungal infections. The evidence is promising but by no means compelling. The adverse effects of TTO are usually mild and transient. They mainly consist of allergic reactions.
  
  
  CONCLUSIONS
  It is concluded that, so far, there is no compelling evidence to show that TTO is efficacious in any dermatological condition. However, in view of promising findings, TTO deserves to be investigated more closely.
authors.affiliation: Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, UK. E.Ernst@ex.ac.uk
authors.forename: E
authors.initials: E
authors.lastname: Ernst
authors.forename: A
authors.initials: A
authors.lastname: Huntley
mesh_terms: D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D000529:Complementary Therapies; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012871:Skin Diseases / Q000188:drug therapy*; D020947:Tea Tree Oil / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D020947:Tea Tree Oil