[Fatty acid composition of lipids in lung tissue of patients with lung cancer].
The fatty acid (FA) spectrum of lung tissue fragments was studied versus distance of malignant cells from lesion focus in lung cancer patients. Decreased polyunsaturated FA levels in all samples were attributed, chiefly, to linoleic, (linoleic-new) and eicosatrienoic acid deficiency. Both in tumor tissue and areas of intensive cell proliferation, accumulation of monounsaturated C18:1 and C15:1 fatty acids, low C20:4(6 and C 20:5(3 and an FA with 19 carbon atoms were detected. The total concentration of (-6 and (-3 series fatty acids was relatively low, too, the deficit of the latter being remarkably low. Those changes are likely to be related to certain peculiarities of the structure and functions of tumor cells.
Khyshiktuev
B S
BS
Medical Academy, Chita.
Aganova
Iu R
IuR
Zhilin
I V
IV
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005227:Fatty Acids / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008168:Lung / Q000737:chemistry*; D008175:Lung Neoplasms / Q000737:chemistry*; D008297:Male; D008875:Middle Aged
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008055:Lipids