A case of papillary meningioma with a t(1;4)(q44;q21).
We report the results of cytogenetic analyses of three cases of meningiomas. The first case, a papillary meningioma, showed only one cytogenetic abnormality, 46,XX,t(1;4)(q44;q21). In contrast, the other two benign fibroblastic meningiomas showed loss of chromosome 22. Loss and/or rearrangement of chromosomes other than chromosome 22 appears to be associated with a more aggressive clinical course. It is suggested that a sole cytogenetic abnormality with a normal chromosome 22 indicates an atypical nature of meningioma.
Go
Y
Y
Department of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan.
Ohjimi
Y
Y
Iwasaki
H
H
Oka
K
K
Ishiguro
M
M
Kaneko
Y
Y
Tsuchimochi
H
H
Tomonaga
M
M
Kikuchi
M
M
D000328:Adult; D002871:Chromosome Banding; D002878:Chromosomes, Human, Pair 1; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic