[Characteristics of the effect of implantation of the human ApoA1 gene on the condition of hepatocytes in rats of varying age].
The results obtained show the essential changes in functional state of hepatocyte's plasmatic membrane due to the implantation of human ApoA1 gene to the rat liver. The changes in phospholipid composition, hyperpolarization, increase in activity of membrane bound enzymes, cytochrome P-450 and biosynthesis of liver total proteins have been found. The essential changes characterizing cell effect were more marked in the adult rats, and membrane effect in the old ones.
Frol'kis
V V
VV
Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kyiv.
Kordium
V A
VA
Kul'chitskiĭ
O K
OK
Novikova
S N
SN
Gulaia
N M
NM
Irolov
D V
DV
Kobzar'
A L
AL
Potapenko
R I
RI
Paramonova
G I
GI
Bogatskaia
L N
LN
Muradian
Kh K
KhK
D000375:Aging / Q000473:pathology*; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D008563:Membrane Lipids / Q000378:metabolism; D008564:Membrane Potentials; D051381:Rats; D017208:Rats, Wistar; D014162:Transfection
D008563:Membrane Lipids