HTLV-1 unrelated adult T-cell leukemia/lymphoma with unique phenotype and karyotype.
We describe a unique case of adult T-cell leukemia/lymphoma (ATL). The patient had typical clinicohematological features as ATL, but showed a lack of antibody to human T-cell leukemia virus type-1 (HTLV-1) and was negative for HTLV-1 proviral DNA in the peripheral mononuclear cells by means of polymerase chain reaction. The phenotype of tumor cells revealed CD7+, CD5+, CD2+, CD3+, WT31-, TcR delta 1-, CD4-, CD8-, CD25-, and the karyotype showed a 5q-, t(12;18). HTLV-1 unrelated ATL is very rare, and the karyotype as in our case has not been reported previously.
Nakase
K
K
Department of Internal Medicine, Saiseikai Matsusaka Hospital, Mie, Japan.
Hasegawa
M
M
Tsuji
K
K
Ikeda
T
T
Tamaki
S
S
Tanigawa
M
M
Miyanishi
E
E
Shiku
H
H
D000368:Aged; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D007621:Karyotyping; D015458:Leukemia, T-Cell / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D008297:Male