Selective group II glutamate metabotropic receptor agonist LY354740 attenuates pentetrazole- and picrotoxin-induced seizures.
There are several data indicating the involvement of metabotropic glutamate receptors (mGluR) in seizures and epileptogenesis. In the present experiments, the selective group II mGluR agonist (+)-2-aminobicyclo-[3.1.0]hexane-2,6-dicarboxylic acid (LY 354740) at doses from 4 to 16 mg/kg) administered prior to the injection of pentetrazole (80 mg/kg) or picrotoxin (3.2 mg/kg) produced a dose-dependent decrease in the number of mice exhibiting clonic convulsions. Our data suggest that group II mGluR agonist LY 354740 possesses antiseizure activity.
Kłodzińska
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Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Chojnacka-Wójcik
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E
Pilc
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D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D010852:Picrotoxin; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D001643:Bridged Bicyclo Compounds; D003292:Convulsants; D018690:Excitatory Amino Acid Agonists; D010433:Pentylenetetrazole; D010852:Picrotoxin; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C104753:eglumetad