[Consequences of interactions between thymic lymphoid and epithelial cells in vitro].
A 24-hour co-cultivation of thymocytes and epithelial cells taken from human thymus results in mutual activation of epitheliocytes and thymocytes, as well as in apoptosis of thymocytes. The apoptosis can also be induced by a cultural supernatant of the thymic-epithelial cells, its level being lower, however, than in the co-culture. Thymocyte death and elimination develop faster in a co-culture with allogeneic thymic epithelial cells.
Iarilin
A A
AA
National Research Centre, Institute of Immunology, Moscow, Russia.
Sharova
N I
NI
Dzutsev
A Kh
AKh
Kolmogorova
V V
VV
D015703:Antigens, CD / Q000276:immunology; D017209:Apoptosis; D002448:Cell Adhesion; D002478:Cells, Cultured; D018920:Coculture Techniques; D004847:Epithelial Cells / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000502:physiology; D013950:Thymus Gland / Q000166:cytology*
D015703:Antigens, CD; D006684:HLA-DR Antigens