title: Health status in allergic rhinitis.
abstract: Although valid and reliable instruments exist to measure the quality of life of allergic rhinitis patients, a statistically sensitive and clinically meaningful way to evaluate patients undergoing immunotherapy has not been reported. A 21-site prospective, observational study was performed in a population of consecutive patients with allergic rhinitis. Baseline general health measures revealed significant (P < 0.05) decrements from reported normative levels in 8 domains for patients choosing to undergo immunotherapy and 5 domains for patients choosing not to undergo immunotherapy. The General Health Survey was less sensitive in detecting change than the Nasal Health Survey (Chronic Sinusitis Survey) and allergy-specific (Rhinoconjunctivitis Quality of Life Questionnaire and Allergy Outcome Survey) surveys. Severity of symptoms was associated with both the likelihood to choose immunotherapy and the likelihood for early improvement. We conclude that general and condition-specific measures can be used to observe patients after immunotherapy; however, obtaining baseline data and controlling for seasonality are important considerations.
authors.affiliation: Department of Surgery, Section of Otolaryngology, University of Chicago, Pritzker School of Medicine, Illinois 60637, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Corey
authors.forename: B J
authors.initials: BJ
authors.lastname: Kemker
authors.forename: J T
authors.initials: JT
authors.lastname: Branca
authors.forename: F
authors.initials: F
authors.lastname: Kuo
authors.forename: Y
authors.initials: Y
authors.lastname: Chang
authors.forename: R E
authors.initials: RE
authors.lastname: Gliklich
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001294:Attitude to Health; D005260:Female; D006304:Health Status; D006801:Humans; D007167:Immunotherapy; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology* / Q000628:therapy; D011795:Surveys and Questionnaires