title: No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status.
abstract: Several studies have reported that the insertion (I) allele of the angiotensin-converting enzyme (ACE) I/deletion (D) polymorphism is associated with enhanced responsiveness to endurance training and is more common in endurance athletes than in sedentary controls. We tested the latter hypothesis in a cohort of 192 male endurance athletes with maximal oxygen uptake >/=75 ml. kg(-1). min(-1) and 189 sedentary male controls. The ACE ID polymorphism in intron 16 was typed with the three-primer polymerase chain reaction method. Both the genotype (P = 0.214) and allele (P = 0.095) frequencies were similar in the athletes and the controls. Further analyses in the athletes revealed no excess of the I allele among the athletes within the highest quartile (> 80 ml. kg(-1). min(-1)) or decile (>83 ml. kg(-1). min(-1)) of maximal oxygen uptake. These data from the GENATHLETE cohort do not support the hypothesis that the ACE ID polymorphism is associated with a higher cardiorespiratory endurance performance level.
authors.affiliation: Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808-4124, USA.
authors.forename: T
authors.initials: T
authors.lastname: Rankinen
authors.forename: B
authors.initials: B
authors.lastname: Wolfarth
authors.forename: J A
authors.initials: JA
authors.lastname: Simoneau
authors.forename: D
authors.initials: D
authors.lastname: Maier-Lenz
authors.forename: R
authors.initials: R
authors.lastname: Rauramaa
authors.forename: M A
authors.initials: MA
authors.lastname: Rivera
authors.forename: M R
authors.initials: MR
authors.lastname: Boulay
authors.forename: Y C
authors.initials: YC
authors.lastname: Chagnon
authors.forename: L
authors.initials: L
authors.lastname: Pérusse
authors.forename: J
authors.initials: J
authors.lastname: Keul
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000483:Alleles; D015331:Cohort Studies; D004251:DNA Transposable Elements; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D010101:Oxygen Consumption; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010807:Physical Endurance / Q000502:physiology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012016:Reference Values; D013177:Sports
chemical_list: D004251:DNA Transposable Elements; D007703:Peptidyl-Dipeptidase A