title: Epiphyseal plate involvement in osteosarcoma.
abstract: Fourteen boys (56%) and 11 girls (44%) 4 to 17 years of age (mean, 12.2 years) who had osteosarcoma and open epiphyseal plates were studied. A possible correlation between transepiphyseal spread of osteosarcoma and radiologic and histopathologic findings was investigated. Epiphyseal plate invasion was detected radiologically in only 11 patients (44%), whereas histopathologic examination showed transepiphyseal extension in 21 patients (84%). The authors conclude that the epiphyseal plate is not a barrier against tumor growth and strongly recommend that limb salvage surgery preserving the epiphysis be planned carefully.
authors.affiliation: Escola Paulista de Medicina, Universidade Federal de São Paulo.
authors.forename: R
authors.initials: R
authors.lastname: Jesus-Garcia
authors.forename: M T
authors.initials: MT
authors.lastname: Seixas
authors.forename: S R
authors.initials: SR
authors.lastname: Costa
authors.forename: A S
authors.initials: AS
authors.lastname: Petrilli
authors.forename: J
authors.initials: J
authors.lastname: Laredo Filho
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006132:Growth Plate / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D012516:Osteosarcoma / Q000473:pathology* / Q000601:surgery; D011379:Prognosis