title: Treatment of infertility due to anejaculation in the male with electroejaculation and intracytoplasmic sperm injection.
abstract: OBJECTIVE
  We tested the hypothesis that spinal cord injury and/or anejaculation affects the outcome of intracytoplasmic sperm injection (ICSI).
  
  
  METHODS
  From November 1993 to October 1998 we obtained and prospectively reviewed data on 34 ICSI cycles using electroejaculated sperm, 620 male factor infertility ICSI cycles using normal ejaculated sperm and 120 cases of obstructive azoospermia, in which microsurgical epididymal aspiration and testicular sperm extraction-ICSI were done in 93 and 27, respectively.
  
  
  RESULTS
  A total of 34 ICSI cycles were performed in 17 couples with male infertility due to anejaculation secondary to spinal cord injury in 10 patients and retroperitoneal lymph node dissection in 5, and idiopathic in 2. In all 17 couples at least 3 previous intrauterine insemination cycles had failed. After electroejaculation 11 men had oligozoospermia and 6 normal sperm density. Median sperm retrieval volume plus or minus standard deviation was 1.9 +/- 1.9 ml., median sperm concentration 70.7 +/- 60.2 x 106 sperm per ml., median motility 10.7% +/- 10.8% and median forward progression 2.3 +/- 0.5 (scale 1 to 4). In the anejaculation group ICSI resulted in a median fertilization of 60% +/- 28%, 15% pregnancies per cycle and 29% pregnancies per couple. In the control group of 620 ICSI cycles from ejaculated specimens obtained from male patients with infertility median fertilization was 58% +/- 26%, and there were 39% pregnancies per cycle and 47% pregnancies per couple. The rate of pregnancies per embryo transfer and per couple was higher in the control than in the electroejaculation-ICSI group (p <0.05). However, there was no statistically significant difference in the fertilization rate.
  
  
  CONCLUSIONS
  ICSI or in vitro fertilization is a viable alternative for patients with anejaculation in whom intrauterine insemination failed. While the fertilization rate is similar in these couples, the pregnancy rate is significantly lower than that achieved with ejaculated specimens from patients with severe male factor infertility. ICSI is a viable alternative for a patient with anejaculation in whom intrauterine insemination or in vitro fertilization failed.
authors.affiliation: Scott Department of Urology, Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: E C
authors.initials: EC
authors.lastname: Schatte
authors.forename: F J
authors.initials: FJ
authors.lastname: Orejuela
authors.forename: L I
authors.initials: LI
authors.lastname: Lipshultz
authors.forename: E D
authors.initials: ED
authors.lastname: Kim
authors.forename: D J
authors.initials: DJ
authors.lastname: Lamb
mesh_terms: D000328:Adult; D004542:Ejaculation; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D013048:Specimen Handling / Q000379:methods; D020554:Sperm Injections, Intracytoplasmic