Sex hormone binding globulins and atherosclerotic risk in systemic lupus.
Sex hormone binding globulin (SHBG) is a transport protein in human plasma which regulates the bioavailability of sex hormones, mediates membrane receptor signaling and may affect inflammatory processes, suggesting a regulatory role for this protein in the prevention of atherosclerosis. The current report summarizes literature implicating several members of the SHBG family in the regulation of hormonal and inflammatory processes which may be pertinent to the accelerated atherosclerosis seen in systemic lupus.
Merrill
J T
JT
St Luke's-Roosevelt Hospital Center, New York, NY 10019, USA.
Lahita
R G
RG
D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology*; D001777:Blood Coagulation; D006706:Homeostasis; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000150:complications*; D017293:Protein S / Q000378:metabolism; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*
D018836:Inflammation Mediators; D017293:Protein S; D012738:Sex Hormone-Binding Globulin