A marine diterpene with a novel tetracyclic framework from the West Indian gorgonian octocoral Pseudopterogorgia elisabethae.
[structure: see text] Colombiasin A (1) was isolated from an extract of the West Indian gorgonian octocoral Pseudopterogorgia elisabethae that showed strong inhibitorial activity against Mycobacterium tuberculosis H37Rv. Structure elucidation by interpretation of 2D-NMR spectroscopic data, IR, UV, and accurate mass measurements (HREI-MS) revealed that colombiasin A belongs to a previously undescribed class of C20 rearranged diterpenes possessing an intricate tetracyclic framework.
Rodríguez
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AD
Department of Chemistry, University of Puerto Rico, San Juan 00931-3346, USA. arodrig@goliath.cnnet.clu.edu
Ramírez
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C
D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013057:Spectrum Analysis
D000995:Antitubercular Agents; D001952:Bridged-Ring Compounds; C408889:colombiasin A