Chemokines and soluble adhesion molecules in renal transplant recipients with cytomegalovirus infection.
Cytomegalovirus (CMV) infection is associated with leucocyte infiltration in various organs, which supports a role for chemokines and adhesion molecules in the pathogenesis of CMV infection. In a prospectively conducted study of renal transplant recipients, 10 patients with CMV disease, five patients with asymptomatic CMV infection and 10 patients who did not have any CMV infection were included. During CMV infection, and in particular during CMV disease, plasma levels of the chemokines IL-8, macrophage inflammatory protein-1alpha (MIP-1alpha) and monocyte chemotactic protein-1 (MCP-1) and the soluble adhesion molecules vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and L-selectin increased and were positively correlated with the degree of CMV pp65 antigenaemia. Furthermore, a decrease in plasma levels of these chemokines and adhesion molecules was observed following ganciclovir therapy in the patients with CMV disease. This could suggest a role for these molecules in the pathogenesis of CMV infection.
Nordøy
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I
Section of Clinical Immunology and Infectious Diseases, Research Institute of Internal Medicine, Medical Department, Rikshospitalet, Oslo, Norway. ingvild.nordoy@klinmed.uio.no
Müller
F
F
Nordal
K P
KP
Rollag
H
H
Aukrust
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P
Frøland
S S
SS
D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000097:blood*; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D003586:Cytomegalovirus Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood*; D016030:Kidney Transplantation / Q000009:adverse effects*; D019041:L-Selectin / Q000097:blood*; D019402:Macrophage Inflammatory Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010750:Phosphoproteins / Q000097:blood; D011446:Prospective Studies; D012995:Solubility; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*; D014763:Viral Matrix Proteins / Q000097:blood
D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D016209:Interleukin-8; D019402:Macrophage Inflammatory Proteins; D010750:Phosphoproteins; D019010:Vascular Cell Adhesion Molecule-1; D014763:Viral Matrix Proteins; C065418:cytomegalovirus matrix protein 65kDa; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin