Relationship between impulsivity and platelet serotonin content in adolescents.
The relationship between impulsivity and serotonin function was explored in impulsive and non-depressed adolescents. Platelet serotonin content was chosen as a peripheral indicator of central serotonin function. Impulsivity was assessed with a questionnaire. All measures were performed once a week over a 6-week period for all subjects. Subjects comprised eight adolescent inpatients who were hospitalized as a result of their impulsive acts and eight healthy age- and sex-matched control subjects. Mean platelet serotonin concentration was significantly higher in the impulsive group than in the control group. Platelet serotonin concentration was positively correlated with the intensity of impulsivity in the patient group.
Askenazy
F
F
Service Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Fondation Lenval, 57 avenue de la Californie, 06200, Nice, France. askenazy@unice.fr
Caci
H
H
Myquel
M
M
Darcourt
G
G
Lecrubier
Y
Y
D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology*; D001792:Blood Platelets / Q000502:physiology; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D012701:Serotonin / Q000097:blood*; D011795:Surveys and Questionnaires; D014754:Violence
D012701:Serotonin