title: Catalyzed hydrolysis of nerve gases by metal chelate compounds and potentiometric detection of the byproducts.
abstract: A new method for detection of nerve gases, Sarin and Soman, was proposed on the basis of their catalyzed hydrolysis by metal chelate compounds and potentiometric detection of the byproduct, fluoride ion. Diisopropyl fluorophosphate (DFP) was used as a nerve gas mimic. The copper ion chelates shift the potential of the fluoride ion-selective electrode to more positive stable potential, which is beneficial for lowering the detection limit. In the presence of DFP, the electrode potential decreases rapidly with time due to the catalyzed hydrolysis of DFP and the production of fluoride ion. This method is sensitive, selective, and reproducible. The detection limit for DFP is 2 x 10(-6) M with a potential drop between 40 and 60 mV.
authors.affiliation: Department of Chemical Engineering, University of South Carolina, Columbia 29208, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Xie
authors.forename: B N
authors.initials: BN
authors.lastname: Popov
mesh_terms: D002384:Catalysis; D002614:Chelating Agents; D002619:Chemical Warfare Agents / Q000032:analysis*; D002800:Cholinesterase Inhibitors; D003300:Copper; D006868:Hydrolysis; D007531:Isoflurophate; D011199:Potentiometry; D012524:Sarin / Q000032:analysis*; D012999:Soman / Q000032:analysis*
chemical_list: D002614:Chelating Agents; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D007531:Isoflurophate; D003300:Copper; D012999:Soman; D012524:Sarin