Salmonella enterica serovars Typhimurium and Dublin can lyse macrophages by a mechanism distinct from apoptosis.
Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene.
Watson
P R
PR
Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom.
Gautier
A V
AV
Paulin
S M
SM
Bland
A P
AP
Jones
P W
PW
Wallis
T S
TS
D000818:Animals; D017209:Apoptosis; D001426:Bacterial Proteins / Q000235:genetics; D061945:Caspase Inhibitors; D002417:Cattle; D016923:Cell Death; D005057:Eukaryotic Cells; D016676:Macrophages, Alveolar / Q000382:microbiology* / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics; D019779:Salmonella enterica / Q000472:pathogenicity*; D012486:Salmonella typhimurium / Q000472:pathogenicity*
D001426:Bacterial Proteins; D061945:Caspase Inhibitors; D008565:Membrane Proteins; C094579:invasion protein B, Salmonella typhimurium