Pulmonary toxicity of inhaled aerosolized prostacyclin therapy--an observational study.
Large white/landrace piglets (mass 11 to 21 kg) were exposed to aerosolized alkaline glycine diluent (n = 2) or inhaled aerosolized prostacyclin (n = 2) for five to eight hours. Pigs receiving these aerosols developed mild acute sterile tracheitis, involving the superficial layers of the trachea, shown histologically and ultrastructurally. Pigs receiving the diluent aerosol also showed mild inflammatory changes in the bronchioles. These findings suggest caution with the use of high volumes of aerosolized alkaline glycine diluent during inhaled aerosolized prostacyclin therapy.
van Heerden
P V
PV
Department of Intensive Care, Sir Charles Gairdner Hospital, Nedlands, W.A.
Caterina
P
P
Filion
P
P
Spagnolo
D V
DV
Gibbs
N M
NM
D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D011464:Epoprostenol / Q000008:administration & dosage / Q000633:toxicity*; D005998:Glycine / Q000008:administration & dosage / Q000633:toxicity; D007249:Inflammation; D008168:Lung / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D009504:Neutrophils / Q000473:pathology; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000633:toxicity*; D013552:Swine; D014132:Trachea / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000633:toxicity*
D000336:Aerosols; D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D011464:Epoprostenol; D005998:Glycine