[Val709-Glu724 streptokinase binding site on plasminogen interacts with streptokinase sequence Thr361-Arg372 during plasminogen-streptokinase complex formation].
Localization of the human plasminogen binding site on the streptokinase of complementary Val709-Glu724 plasminogen being crucial one in providing for the plasminogen streptokinase complex activity has been investigated. Experiments were performed with streptokinase fragments and synthetic decapeptides, antiplasminogen monoclonal anti-body IV-1c and synthetic peptide corresponding to Val709-Gly718 sequence of human plasminogen. It was found that plasminogen sequence Val709-Glu724 interacted with Thr361-Arg372 sequence of strepto-kinase.
Korol'chuk
V I
VI
D001665:Binding Sites; D006801:Humans; D010958:Plasminogen / Q000737:chemistry / Q000378:metabolism*; D013300:Streptokinase / Q000378:metabolism*
D010958:Plasminogen; D013300:Streptokinase