Cadmium induced lipid peroxidation in rat testes and protection by selenium.
The main goal of this study was to investigate the role of cadmium in the promotion of lipid peroxidation in the homogenates of rat testes and the effect of selenium on lipid peroxidation in testes of rats after cadmium injection. Treatment of rats with cadmium resulted in a time- and dose-related accumulation of the metal ions in testes. The concentrations of cadmium, copper, zinc, selenium and iron in the tissues were determined by an atomic absorption spectrophotometer and lipid peroxidation in testes was measured by a spectrophotometer. Cadmium produced enhanced lipid peroxidation in testes. These cadmium-induced changes were accompanied by a significant increase of iron and copper, and a decrease of zinc in testes. Concurrent treatment with selenium and cadmium reduced the cadmium-induced alterations in lipid peroxidation and essential metal levels. Data suggest that lipid peroxidation was associated with cadmium toxicity in testes and that the addition of selenium was found to be effective in attenuation of this effect.
Yiin
S J
SJ
Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan.
Chern
C L
CL
Sheu
J Y
JY
Lin
T H
TH
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D019256:Cadmium Chloride / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D064586:Selenic Acid; D018036:Selenium Compounds / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014131:Trace Elements / Q000378:metabolism
D000975:Antioxidants; D018036:Selenium Compounds; D017392:Thiobarbituric Acid Reactive Substances; D014131:Trace Elements; D002104:Cadmium; D064586:Selenic Acid; D019256:Cadmium Chloride