title: Active infective endocarditis: low mortality associated with early surgical treatment.
abstract: BACKGROUND
  Early surgical treatment is important for successful outcome in selected cases of active, either native (NVE) or prosthetic valve endocarditis (PVE). The aim of this study was to evaluate the early results of the surgical treatment of active NVE and PVE.
  
  
  METHODS
  During a 3-yr period (January 1 1996-December 31 1998), 57 out of 60 patients (pts) with active, either NVE (46 pts) or PVE (11 pts) underwent surgical treatment. There were 11 women (23.9%), average age of the group being 43.3+/-9.1yr (18-73). They were operated on 12-35days, mean 17.7+/-7.5days (for NVE) and 5-33days, mean 13.2+/-10.1days (for PVE) after the diagnosis of endocarditis was first suspected. All pts had at least one absolute indication for early surgical treatment, the most frequent being (in NVE) worsening heart failure (19 cases) and inability to control the infection (10 cases), while in PVE it was valve dehiscence (8 cases). In 8 cases of NVE and 2 cases of PVE fresh, antibiotic sterilized aortic homograft was used to replace the aortic valve.
  
  
  RESULTS
  Operative mortality was 1.8% (1/57) and hospital mortality 5.2% (3/57). Three pts with PVE died before they were operated on, giving an overall mortality of 10% (6/60). Postoperative morbidity included valve dehiscence in two pts (probable late onset recurrent endocarditis - 3.5%), three episodes of acute renal failure (5.3%), four cases of respiratory insufficiency (7.0%) and one chronic pleural effusion (1.8%). All pts that were discharged from the hospital (54/60), are still alive and well 1-35months postoperatively (mean 20.3+/-9.6months), including pts with recurrent endocarditis and valve dehiscence, after they were successfully reoperated.
  
  
  CONCLUSIONS
  Along with early diagnosis and appropriate antibiotic treatment, aggressive surgical attitude is of importance for the successful outcome in this group of seriously ill patients. Our data indicate that early surgical treatment in cases of active endocarditis may be associated with low mortality and morbidity.
authors.affiliation: Department of Cardiac Surgery, Dedinje Cardiovascular Institute and Belgrade University Medical School, Belgrade, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Perić
authors.forename: F
authors.initials: F
authors.lastname: Vuk
authors.forename: R
authors.initials: R
authors.lastname: Huskić
authors.forename: L
authors.initials: L
authors.lastname: Lausević-Vuk
authors.forename: A N
authors.initials: AN
authors.lastname: Nesković
authors.forename: M
authors.initials: M
authors.lastname: Borzanović
authors.forename: M
authors.initials: M
authors.lastname: Bojić
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004697:Endocarditis, Bacterial / Q000382:microbiology / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000401:mortality* / Q000601:surgery*; D013997:Time Factors