title: Survival of bacteria during oxygen limitation.
abstract: Regulatory mechanisms that enable bacteria associated with food, drinks and the human body to adapt to changes in the availability of oxygen are reviewed. Excess oxygen induces two adaptive responses to oxidative stress. Five or more control circuits enable enteric bacteria to generate energy and grow well in anaerobic environments. Two sets of enzymes catalyse both nitrate and nitrite reduction, and dual two-component regulatory systems sense and respond to the available nitrate and nitrite in the environment. The periplasmic nitrate reductase enables bacteria to scavenge low concentrations of nitrate: similar systems are found in food-borne and other pathogens.
authors.affiliation: School of Biochemistry, University of Birmingham, UK.
authors.forename: L
authors.initials: L
authors.lastname: Potter
authors.forename: P
authors.initials: P
authors.lastname: Millington
authors.forename: L
authors.initials: L
authors.lastname: Griffiths
authors.forename: J
authors.initials: J
authors.lastname: Cole
mesh_terms: D000693:Anaerobiosis; D001419:Bacteria / Q000254:growth & development*; D005516:Food Microbiology; D006801:Humans; D050901:Nitrate Reductase; D009565:Nitrate Reductases / Q000502:physiology; D018384:Oxidative Stress
chemical_list: D009565:Nitrate Reductases; D050901:Nitrate Reductase