Synthesis of enamides related to the salicylate antitumor macrolides using copper-mediated vinylic substitution
[formula: see text] A new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides. Modified reaction conditions have been developed to synthesize the O-methyloxime enamide side chains related to the natural products lobatamides A-F, oximidine I and II, and CJ-12,950.
Shen
R
Department of Chemistry, Metcalf Center for Science and Engineering, Boston University, Massachusetts 02215, USA.
Porco
JA