title: Bromocriptine for unexplained subfertility in women.
abstract: BACKGROUND
  Bromocriptine improves hyperprolactinemic amenorrhea and so could also be helpful in the treatment of unexplained subfertility in women.
  
  
  OBJECTIVE
  To assess the effects of bromocriptine in women with unexplained subfertility.
  
  
  METHODS
  The Cochrane Subfertility Review Group specialised register of controlled trials was searched.
  
  
  METHODS
  Randomised trials comparing bromocriptine with placebo or no treatment in women with unexplained subfertility.
  
  
  METHODS
  Two reviewers applied the eligibility criteria and assessed trial quality independently.
  
  
  RESULTS
  Three trials involving of 127 women were included. All trials were double-blind comparisons with placebo, and one was of crossover design. Conception rates with bromocriptine treatment did not improve compared with placebo (odds ratio was 1.12, 95% confidence interval 0.48 to 2.57).
  
  
  CONCLUSIONS
  There is not enough evidence to evaluate bromocriptine use in women with unexplained subfertility. However trials for women with unexplained subfertility who also have expressible galactorrhea may be worthwhile.
authors.affiliation: Rm HSC-4F7, Department of Obstetrics and Gynaecology, McMaster University, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5. hughese@fhs.csu.mcmaster.ca
authors.forename: E
authors.initials: E
authors.lastname: Hughes
authors.forename: J
authors.initials: J
authors.lastname: Collins
authors.forename: P
authors.initials: P
authors.lastname: Vandekerckhove
mesh_terms: D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*
chemical_list: D006727:Hormone Antagonists; D001971:Bromocriptine