Human alpha-fetoprotein transcriptional regulatory sequences. Application to gene therapy.
The AFP regulatory sequences are among the best known tumor-specific transcriptional regulators. A number of groups have demonstrated that a variety of genes can be expressed in an HCC-specific manner under the control of the AFP regulatory sequences in vitro and in vivo. It would appear that, with the development of a suitable delivery system, HCC-directed gene therapy using the AFP regulatory sequences holds a promising future.
Tamaoki
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Department of Biochemistry and Molecular Biology, University of Calgary, Alberta, Canada.
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000628:therapy; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy; D012045:Regulatory Sequences, Nucleic Acid; D014158:Transcription, Genetic; D000509:alpha-Fetoproteins / Q000235:genetics*
D000509:alpha-Fetoproteins