title: Predictors of functional outcomes following limb salvage surgery for lower-extremity soft tissue sarcoma.
abstract: OBJECTIVE
  Patient function has been conceptualized by clinical measures such as joint motion, muscle strength, disability, and general health status. The purpose of the current study was to evaluate tumor and treatment variables predictive of these conceptually different posttreatment functional outcomes in patients treated with limb preservation surgery for lower-extremity soft tissue sarcoma.
  
  
  METHODS
  One hundred seventy-two patients with minimum 1-year follow-up were evaluated using the following outcomes: impairment, measured by the 1987 and 1993 versions of the Musculoskeletal Tumor Society Rating Scale (MSTS); disability, measured by the Toronto Extremity Salvage Score (TESS); and general health status, using the Short Form-36 (SF-36). Tumor and treatment-related variables (age, gender, presenting disease status, anatomic site, tumor size, grade, depth, prior excision, irradiation, bone resection, motor nerve sacrifice, and complications) were extracted from the STS database.
  
  
  RESULTS
  Large tumor size, bone resection, motor nerve resection, and complications were predictive of lower MSTS 1987 and 1993 scores. Patients with large, high-grade tumors who required motor nerve resection were more disabled, as reflected by lower TESS scores. Only age and prior surgery were adverse predictors of SF-36 score.
  
  
  CONCLUSIONS
  These results demonstrate that different factors are predictive of different patient outcomes, specifically, impairment, disability, and general health status. It is important to define function when counseling patients regarding their potential recovery based on tumor and treatment-related variables. J. Surg. Oncol. 2000;73:206-211.
authors.affiliation: University Musculoskeletal Oncology Unit, Mount Sinai Hospital and the University of Toronto, Toronto, Canada. davis@mshri.on.ca
authors.forename: A M
authors.initials: AM
authors.lastname: Davis
authors.forename: S
authors.initials: S
authors.lastname: Sennik
authors.forename: A M
authors.initials: AM
authors.lastname: Griffin
authors.forename: J S
authors.initials: JS
authors.lastname: Wunder
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: C N
authors.initials: CN
authors.lastname: Catton
authors.forename: R S
authors.initials: RS
authors.lastname: Bell
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000704:Analysis of Variance; D006233:Persons with Disabilities / Q000145:classification; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006304:Health Status; D006801:Humans; D007866:Leg / Q000294:innervation / Q000502:physiology / Q000601:surgery*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology; D015999:Multivariate Analysis; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology; D010027:Osteotomy; D011183:Postoperative Complications; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D016059:Range of Motion, Articular / Q000502:physiology; D012509:Sarcoma / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000601:surgery*; D016896:Treatment Outcome