T-cell memory: You must remember this ...
While antigen-inexperienced (naive) T cells appear to require constant tickling of their receptor by self-antigens for homeostasis, antigen-experienced (memory) T cells have no such requirement. An implication is that long-term T-cell memory does not depend on persisting antigen.
Bevan
M J
MJ
Department of Immunology, Howard Hughes Medical Institute, University of Washington, Seattle, 98195, USA. mbevan@u.washington.edu
Goldrath
A W
AW
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D019409:Interleukin-15 / Q000276:immunology*; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2 / Q000276:immunology
D015395:Histocompatibility Antigens Class I; C508024:IL15RA protein, human; D019409:Interleukin-15; D053647:Receptors, Interleukin-15; D015375:Receptors, Interleukin-2