[Myocardial infarction as a cause of death in patients treated for small cell lung cancer].
The aim of our study was to assess frequency of death from myocardial infarction in patients (pts) treated for small cell lung cancer (SCLC). 33 out of 845 patients treated for SCLC died from myocardial infarction. All patients were smokers. In 6 patients coexisted hypertension, in 2--diabetes and in 5--obesity. Eight patients have had cardiac disease in anamnesis. All patients were treated with one or more number of cardiotoxic drugs as DDP, VCR or VBL, E, MTX and ADR which are able to cause ischemic heart disease or myocardial infarction. Sixteen out of 33 patients have had radiotherapy of lung tumour. Death from myocardial infarction occurred from 0.5 up till 98.5 months from the beginning of start treatment. Eighteen men died from myocardial infarction in the first year of treatment. Risk of death from myocardial infarction was 15 times greater in men with SCLC than in men of the polish population at the same age and at the same time.
Remiszewski
P
P
III Klinika Gruźlicy i Chorób Płuc, Instytutu Gruźlicy i Chorób Płuc.
Słodkowska
J
J
Szczepek
B
B
Decker
E
E
Marzinek
M
M
Rowińska-Zakrzewska
E
E
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D018288:Carcinoma, Small Cell / Q000453:epidemiology* / Q000628:therapy; D002423:Cause of Death; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D009765:Obesity / Q000453:epidemiology; D011044:Poland / Q000453:epidemiology; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D012907:Smoking / Q000453:epidemiology