Use of radiation therapy in posttransplant lymphoproliferative disorder (PTLD) after liver transplantation.
Posttransplant lymphoproliferative disorder (PTLD) is a common and life-threatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants. There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed a solitary lymphoproliferative lesion in the porta hepatis 9 months after orthotopic liver transplant. Following reduction in immunosuppression with no response, she was treated with involved field radiotherapy utilizing CT-based treatment planning. A partial radiographic response was obtained, and she has not developed disease in the engrafted liver or systemically. Based on the present case report, involved field radiotherapy seems to be a reasonable treatment option for patients with localized PTLD. Int. J. Cancer (Radiat. Oncol. Invest.) 90:104-109, 2000.
Koffman
B H
BH
Department of Radiation Oncology, University of Maryland Medical System, Baltimore, Maryland, USA.
Kennedy
A S
AS
Heyman
M
M
Colonna
J
J
Howell
C
C
D000465:Algorithms; D016572:Cyclosporine / Q000009:adverse effects; D020031:Epstein-Barr Virus Infections; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D006526:Hepatitis C; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008103:Liver Cirrhosis / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000532:radiotherapy / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000532:radiotherapy*; D008875:Middle Aged; D011241:Prednisone / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011241:Prednisone