Luteinizing hormone receptor expression in leiomyomatosis peritonealis disseminata.
BACKGROUND
Leiomyomatosis peritonealis disseminata has been attributed to estrogen stimulation and is seen only rarely in postmenopausal women. In such cases, pathogenesis is uncertain.


METHODS
Leiomyomatosis peritonealis disseminata tumors were resected from a postmenopausal woman. She was receiving tamoxifen therapy for breast cancer and had bilateral ovarian Brenner tumors. Estrogen and progesterone receptors were detected. Immunohistochemical analysis indicated that LH receptors were present.


CONCLUSIONS
Luteinizing hormone receptors were identified in leiomyomatosis peritonealis disseminata in one woman. Levels of FSH and LH increase after menopause, and immunohistochemical analysis showed the presence of LH receptors, so gonadotropin rather than estrogen stimulation might have contributed to development of leiomyomatosis peritonealis disseminata in this uncommon case.
Danikas
D
D
Department of Surgery, Newark Beth Israel Medical Center, Newark, New Jersey, USA.
Goudas
V T
VT
Rao
C V
CV
Brief
D K
DK
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D001948:Brenner Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018231:Leiomyomatosis / Q000378:metabolism*; D008875:Middle Aged; D016609:Neoplasms, Second Primary; D010051:Ovarian Neoplasms / Q000378:metabolism*; D017698:Postmenopause; D011974:Receptors, LH / Q000378:metabolism*; D013629:Tamoxifen / Q000627:therapeutic use
D018931:Antineoplastic Agents, Hormonal; D011974:Receptors, LH; D013629:Tamoxifen