title: Proton spectroscopic imaging of polyacrylamide gel dosimeters for absolute radiation dosimetry.
abstract: Proton spectroscopy has been evaluated as a method for quantifying radiation induced changes in polyacrylamide gel dosimeters. A calibration was first performed using BANG-type gel samples receiving uniform doses of 6 MV photons from 0 to 9 Gy in 1 Gy intervals. The peak integral of the acrylic protons belonging to acrylamide and methylenebisacrylamide normalized to the water signal was plotted against absorbed dose. Response was approximately linear within the range 0-7 Gy. A large gel phantom irradiated with three, coplanar 3 x 3 cm square fields to 5.74 Gy at isocentre was then imaged with an echo filter technique to map the distribution of monomers directly. The image, normalized to the water signal, was converted into an absolute dose map. At the isocentre the measured dose was 5.69 Gy (SD = 0.09) which was in good agreement with the planned dose. The measured dose distribution elsewhere in the sample shows greater errors. A T2 derived dose map demonstrated a better relative distribution but gave an overestimate of the dose at isocentre of 18%. The data indicate that MR measurements of monomer concentration can complement T2-based measurements and can be used to verify absolute dose. Compared with the more usual T2 measurements for assessing gel polymerization, monomer concentration analysis is less sensitive to parameters such as gel pH and temperature, which can cause ambiguous relaxation time measurements and erroneous absolute dose calculations.
authors.affiliation: Joint Department of Physics, The Institute of Cancer Research, The Royal Marsden NHS Trust, Sutton, Surrey, UK. pmurphy@icr.ac.uk
authors.forename: P S
authors.initials: PS
authors.lastname: Murphy
authors.forename: V P
authors.initials: VP
authors.lastname: Cosgrove
authors.forename: A J
authors.initials: AJ
authors.lastname: Schwarz
authors.forename: S
authors.initials: S
authors.lastname: Webb
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
mesh_terms: D002138:Calibration; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D019047:Phantoms, Imaging; D011522:Protons; D011874:Radiometry / Q000379:methods*; D013057:Spectrum Analysis / Q000379:methods; D013696:Temperature; D013997:Time Factors
chemical_list: D011522:Protons