title: Hypercoagulable states.
abstract: The hypercoagulable state has been defined as the potential to develop thrombosis in association with hereditary and noninherited genetic mutations and acquired disorders. It is a condition that places an individual at risk for, but does not in itself inevitably lead to, thrombosis. The focus of this article is understanding mechanisms in the hypercoagulable state that enhance and maintain the production of thrombin in circulating blood while preventing its progression to thrombosis. These mechanisms include reactions that produce thrombin from prothrombin, feedback loop mechanisms that affect the rate of thrombin production from prothrombin and the inactivation of thrombin in blood. The fibrinolytic system is involved in clot lysis but not in thrombin production and inactivation.
authors.affiliation: Department of Medicine, Michigan State University, East Lansing, USA.
authors.forename: T
authors.initials: T
authors.lastname: Whiteman
authors.forename: H I
authors.initials: HI
authors.lastname: Hassouna
mesh_terms: D000991:Antithrombins; D019774:Blood Coagulation Factor Inhibitors / Q000172:deficiency / Q000235:genetics; D004211:Disseminated Intravascular Coagulation / Q000235:genetics; D005260:Female; D005342:Fibrinolysis / Q000235:genetics; D006487:Hemostasis; D006801:Humans; D008297:Male; D011516:Prothrombin / Q000378:metabolism; D019851:Thrombophilia; D013927:Thrombosis / Q000235:genetics
chemical_list: D000991:Antithrombins; D019774:Blood Coagulation Factor Inhibitors; D011516:Prothrombin