Postnatal evolution of supernumerary ribs in rats after a single administration of sodium salicylate.
Radiographs were used to follow the postnatal evolution of 14th ribs in rat pups. Initially, 30 pregnant female rats were randomly distributed into two groups receiving 0 or 300 mg kg(-1) sodium salicylate on day 9 of pregnancy. In the treated group, adverse effects were noted on body weight changes and food consumption during the 2 days following dosing. At birth, a high majority of pups had extra ribs at the 300 mg kg(-1) dose. Radiographs done on postnatal days 1, 6, 14, 28 and 54 showed a reduction in the incidence of rudimentary ribs only, whereas extra ribs, often associated with 27 presacral vertebrae, had the same incidence from birth to adult stage. Furthermore, extra ribs seemed to exhibit similar growth evolution to the other thoracic ribs. This work helps to clarify the postnatal evolution of supernumerary ribs because it was performed on the same animals from birth to adult stage, showing that the reversibility was related to rib length and, in consequence, concerned the rudimentary ribs only. The coexistence of additional presacral vertebrae primarily with extra ribs suggests that both kinds of supernumerary ribs (rudimentary and extra) might be different phenomena and could be considered separately in developmental toxicology studies.
Foulon
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Aventis CropScience, 355 rue Dostoievski, BP153, F-06903 Sophia Antipolis Cedex, France. olivia.foulon@aventis.com
Jaussely
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Repetto
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Urtizberea
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Blacker
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D000014:Abnormalities, Drug-Induced / Q000000981:diagnostic imaging / Q000473:pathology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011859:Radiography; D051381:Rats; D012272:Ribs / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000254:growth & development*; D012980:Sodium Salicylate / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012980:Sodium Salicylate