title: Effect of cholesterol levels on villous histology in colonic adenomas.
abstract: To date no studies have examined the relationship between cholesterol levels and the occurrence of specific colonic polyp histologies. Villous histology has a greater predilection for subsequent malignancies than other histologies. Consequently, we examined the effect of cholesterol levels on the occurrence of villous adenomas. Just under one in 10 (9.5%, 15/158) patients had polyps with villous histologies. Cholesterol levels were positively and nonlinearly associated with a greater likelihood of villous histology, suggesting that a threshold exists for the effect of cholesterol level on the likelihood of having polyps with villous histology [odds ratios (OR) for combined two variable quadratic effect: cholesterol OR, 1.18; 95% confidence interval (CI), 1.02-1.37 and cholesterol squared OR, 1.004; 95% CI, 1.00-1.02]. Our data suggest that, in patients with polyps, higher cholesterol levels increase the likelihood of having polyps with villous histology, but that the effect of cholesterol level reaches a threshold.
authors.affiliation: Saint Barnabas Medical Center, Livingston, New Jersey, USA.
authors.forename: J
authors.initials: J
authors.lastname: Houghton
authors.forename: G G
authors.initials: GG
authors.lastname: Lardieri
authors.forename: N P
authors.initials: NP
authors.lastname: Zauber
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.forename: G
authors.initials: G
authors.lastname: Cable
mesh_terms: D018253:Adenoma, Villous / Q000097:blood / Q000473:pathology*; D000328:Adult; D000368:Aged; D001706:Biopsy; D002784:Cholesterol / Q000097:blood*; D003110:Colonic Neoplasms / Q000097:blood / Q000473:pathology*; D003111:Colonic Polyps / Q000097:blood / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D002784:Cholesterol