title: Effect of short-term hyperventilation on cerebral blood flow autoregulation in patients with acute bacterial meningitis.
abstract: OBJECTIVE
  Cerebral blood flow (CBF) autoregulation is impaired in patients with acute bacterial meningitis: this may be caused by cerebral arteriolar dilatation. We tested the hypothesis that CBF autoregulation is recovered by acute mechanical hyperventilation in 9 adult patients with acute bacterial meningitis.
  
  
  METHODS
  Norepinephrine was infused to increase mean arterial pressure (MAP) 30 mm Hg from baseline. Relative changes in CBF were concomitantly recorded by transcranial Doppler ultrasonography of the middle cerebral artery, measuring mean flow velocity (V(mean)), and by measurement of arterial to jugular oxygen content difference (a-v DO(2)). The slope of the regression line between MAP and V(mean) was calculated. Measurements were performed during normoventilation and repeated after 30 minutes of mechanical hyperventilation.
  
  
  RESULTS
  At normoventilation (median PaCO(2) 4.4 kPa, range 3.5 to 4.9), MAP was increased from 68 mm Hg (60 to 101) to 109 mm Hg (95 to 126). V(mean) increased with MAP from 48 cm/s (30 to 61) to 65 cm/s(33 to 86) (P<0.01), and a-v DO(2) decreased from 2.2 mmol/L (1.0 to 2.7) to 1.4 mmol/L (0.8 to 1.8) (P<0.05). During hyperventilation (PaCO(2) 3.5 kPa, range 3.3 to 4.1), MAP was increased from 76 mm Hg (58 to 92) to 109 mm Hg (95 to 121). V(mean) increased from 45 cm/s (29 to 55) to 53 cm/s (33 to 78) (P<0.01), and a-v DO(2) decreased from 2.5 mmol/L (1.8 to 3.0) to 1.8 mmol/L (1.2 to 2.4) (P<0.05). Four patients recovered autoregulation completely during hyperventilation. The slope of the autoregulation curve decreased during hyperventilation compared with normoventilation (P<0.05).
  
  
  CONCLUSIONS
  CBF autoregulation is partially recovered during short-term mechanical hyperventilation in patients with acute bacterial meningitis, indicating that cerebral arteriolar dilation in part accounts for the regulatory impairment of CBF in these patients.
authors.affiliation: Departments of Infectious Diseases, University Hospital Rigshospitalet, Copenhagen, Denmark. kirsten.moller@dadlnet.dk
authors.forename: K
authors.initials: K
authors.lastname: Møller
authors.forename: P
authors.initials: P
authors.lastname: Skinhøj
authors.forename: G M
authors.initials: GM
authors.lastname: Knudsen
authors.forename: F S
authors.initials: FS
authors.lastname: Larsen
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D005260:Female; D006706:Homeostasis; D006801:Humans; D006985:Hyperventilation; D008297:Male; D016920:Meningitis, Bacterial / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D012121:Respiration, Artificial; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial