Stimulation of rat cutaneous fibroblasts and their synthetic activity by implants of powdered nacre (mother of pearl).
The components of the cutaneous envelope, the epidermis and the dermis, change in response to aging or environmental stress factors. The fibroblasts involved in maintaining skin tone are the main targets. Nacre, mother of pearl, from Pinctada maxima, which can stimulate and regulate bone forming cells, was implanted in the dermis of rats to test its action on the skin fibroblasts. This report describes the effect of nacre on the skin fibroblast recruitment and physiological activity. It resulted in enhanced extracellular matrix synthesis and the production of components implicated in cell to cell adhesion and communication (such as decorine) and in tissue regeneration (type I and type III collagens). The nacre implant produced a well vascularized tissue. The physiological conditions in the region around the implant are thus those required for the positive interactions between the dermis and epidermis which are fundamental for the physiological function of the skin.
Lopez
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Laboratoire de Physiologie Générale et Comparée, URA CNRS 90, Muséum National d'Histoire Naturelle, Paris, France. lopez@mnhn.fr
Le Faou
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A
Borzeix
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Berland
S
S
D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D004268:DNA-Binding Proteins / Q000494:pharmacology*; D058575:Decorin; D004343:Drug Implants; D005109:Extracellular Matrix / Q000378:metabolism; D016326:Extracellular Matrix Proteins; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism; D007150:Immunohistochemistry; D051739:Microphthalmia-Associated Transcription Factor; D011208:Powders; D011509:Proteoglycans / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology; D013194:Staining and Labeling; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C546880:Dcn protein, rat; D058575:Decorin; D004343:Drug Implants; D016326:Extracellular Matrix Proteins; D051739:Microphthalmia-Associated Transcription Factor; C497236:Mitf protein, rat; D011208:Powders; D011509:Proteoglycans; D014157:Transcription Factors; D003094:Collagen