Synthetic approaches towards benzo[h]quinoline-3-carbonitriles.
2-Alkoxybenzo[h]quinoline-3-carbonitriles 2 were readily synthesized via Dimroth rearrangement of 2-amino-4-aryl-5,6-dihydro-4H-naphtho[1,2-b]pyran-3-carbonitriles 5 induced by ethanolic and methanolic KOH. Compounds 2 were also obtained by the reaction of 2-arylmethylidene-3,4-dihydro-1(2H)-naphthalenones 1 with malononitrile or of ylidenemalononitriles 4 with 1,2,3,4-tetrahydro-1-naphthalenone in ethanolic and methanolic KOH. The molluscicidal activity of the products towards Biomphalaria alexandrina snails was screened.
Mishriky
N
N
National Research Centre, Dokki, Cairo, Egypt.
Ibrahim
Y A
YA
Girgis
A S
AS
Fawzy
N G
NG
D000818:Animals; D001700:Biomphalaria; D009682:Magnetic Resonance Spectroscopy; D008975:Molluscacides / Q000138:chemical synthesis* / Q000494:pharmacology; D009570:Nitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D008975:Molluscacides; D009570:Nitriles; D011804:Quinolines