[An evaluation of the effect of 2,4-dichlorophenoxyacetic acid derivatives on humoral and cellular immunities].
A single oral administration of phenoxy herbicides, viz. 2,4-dichlorophenoxyacetic acid (2,4-D), amino salt, sodium salt, diethylene glycol, iso-octyl and octyl ethers in a dose of LD16, was found to produce a pronounced suppressive effect on humoral immunity on day 5. The 2,4-D derivatives under study, administered in the same dose, stimulated the manifestations of delayed-type hypersensitivity in mice immunized with sheep red blood cells. The effect of the inhibition of antibody formation to thymus-dependent antigen ranged in the order of the increase in the toxicity of substances: amino salt, diethylene glycol ether, 2,4-D, sodium salt, iso-octyl and octyl ethers. On the contrary, the intensity of delayed-type hypersensitivity was more pronounced with regard to substances having greater toxicity.
Imel'baeva
E A
EA
Bashkir State Medical University, Ufa, Russia.
Teplova
S N
SN
Kamilov
F Kh
FKh
D015084:2,4-Dichlorophenoxyacetic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D006540:Herbicides / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects*; D007114:Immunization / Q000379:methods; D008297:Male; D051379:Mice
D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid