title: [Efficacy of continuous intravenous drip infusion of disopyramide in hypertrophic obstructive cardiomyopathy during cardiogenic shock: a case report].
abstract: A 54-year-old woman was admitted to our hospital complaining of dyspnea due to hypertrophic obstructive cardiomyopathy. On admission, she was treated with 4 antiarrhythmic drugs and 2 beta-blockers. After 4 of these 6 drugs were withdrawn, the left ventricular outflow pressure gradient markedly increased and then she fell into cardiogenic shock. Therefore, disopyramide(600 mg/day) was administered by continuous intravenous drip infusion to reduce the left ventricular outflow pressure gradient. After intravenous administration of disopyramide, the left ventricular outflow pressure gradient markedly decreased from 100 to 16 mmHg and the cardiogenic shock could be improved. Continuous intravenous drip infusion of disopyramide is effective for the treatment of cardiogenic shock due to severe left ventricular outflow obstruction in patients with hypertrophic obstructive cardiomyopathy.
authors.affiliation: Department of Cardiology, Heart Institute of Japan, Tokyo Women's Medical University.
authors.forename: K
authors.initials: K
authors.lastname: Kajimoto
authors.forename: T
authors.initials: T
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Imamura
authors.forename: N
authors.initials: N
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Niki
authors.forename: N
authors.initials: N
authors.lastname: Hagiwara
authors.forename: H
authors.initials: H
authors.lastname: Kasanuki
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000188:drug therapy*; D004206:Disopyramide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000889:Anti-Arrhythmia Agents; D004206:Disopyramide