title: Severe pre-eclampsia and eclampsia.
abstract: The mainstay of the management of severe pre-eclampsia is early referral, stabilization of the mother with antihypertensive therapy and anticonvulsants if required, full assessment of the mother and the baby, and delivery on the best day in the best way. It is to be remembered that delivery is the long-term cure, but most women get worse after delivery and most maternal deaths occur postpartum. It is important that doctors have the training to be aware of the dangers of this condition, guidelines to follow and senior support. Lowering blood pressure has been associated with a reduction in the mortality from cerebrovascular accident and early use of antihypertensive agents is beneficial to both mother and baby. The main cause of death is now pulmonary oedema, with renal failure a rare complication. It is important that, after delivery, vigilance is maintained and fluid replacement is given with care. It is better to 'run them dry' than to give fluid replacement that may encourage pulmonary oedema. Followup is required with counselling about what has happened and the prospects of recurrence.
authors.affiliation: Department of Obstetrics and Gynaecology, St James University Hospital, Leeds, UK.
authors.forename: J J
authors.initials: JJ
authors.lastname: Walker
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002585:Cesarean Section; D002985:Clinical Protocols; D004461:Eclampsia / Q000401:mortality / Q000517:prevention & control / Q000628:therapy*; D005260:Female; D005323:Fetal Monitoring / Q000379:methods; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008428:Maternal Mortality; D011225:Pre-Eclampsia / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D011247:Pregnancy; D011654:Pulmonary Edema / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D020521:Stroke / Q000209:etiology / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D000959:Antihypertensive Agents; D008278:Magnesium Sulfate