High throughput gene expression screening: its emerging role in drug discovery.
The genetic makeup and the environment influences the health and welfare of an individual. At both the tissue and cellular level, physiological function can be correlated with the transcription of genes, whose protein products contribute and influence the activity of biological systems. In order to understand these processes, it is therefore essential to determine the temporal and spatial patterns of gene expression, and, with particular relevance to drug discovery, define changes that occur during development of disease or treatment with therapeutic agents.
Freeman
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Gene Expression Group, The Sanger Centre, Hinxton Hall, Cambridge, UK.
D015195:Drug Design; D015870:Gene Expression; D005821:Genetic Techniques; D006801:Humans