title: Airway growth after cricotracheal resection in a rabbit model and clinical application to the treatment of subglottic stenosis in children.
abstract: OBJECTIVE
  To evaluate the effects of a partial resection of the anterior cricoid arch on the growth of the laryngotracheal complex in an animal model and to study the lumen caliber and cross sectional surface area following resection as the animals are allowed to grow. Laryngeal, subglottic, and tracheal measurements in the infant and pediatric larynges in autopsy specimens are also investigated.
  
  
  METHODS
  A controlled animal study was done comparing the operated rabbit group to the nonoperated group. Twenty-nine infant rabbits were compared to a control group of ten rabbits. In addition, autopsy dissections were performed on infant and pediatric larynges to obtain measurements of various laryngeal and cricoid relationships.
  
  
  METHODS
  Thirty-nine pasteurella-free New Zealand white female rabbits between the ages of 8 and 11 weeks were used in this study. In the experimental group, cricotracheal resections were performed by removing the anterior cricoid cartilage and the first tracheal ring. A primary anastomosis was then performed. The animals were kept alive for 4 months and then humanely euthanized. The laryngeal complex was then removed and histological sections of the cricotracheal region were mounted on glass slides and stained with H&E. Measurements were taken of the cricoid and upper tracheal lumen and cross-sectional area.
  
  
  RESULTS
  Twenty-seven of the study group survived until the time of sacrifice. All of the control group survived during the study period. The two groups were comparable in regard to weight, lumen size, and cross-sectional area There were no statistical differences between the groups.
  
  
  CONCLUSIONS
  The experimental data support the hypothesis that partial cricotracheal resections can be performed safely and effectively in young rabbits. The potential clinical significance is described in light of the autopsy data.
authors.affiliation: Department of Otolaryngology, Weill Medical College of Cornell University, New York, New York, USA. nyoi_ward@I-2000.com
authors.forename: R F
authors.initials: RF
authors.lastname: Ward
authors.forename: J M
authors.initials: JM
authors.lastname: Triglia
mesh_terms: D000367:Age Factors; D000714:Anastomosis, Surgical; D000818:Animals; D000886:Anthropometry; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D003413:Cricoid Cartilage / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D007829:Laryngostenosis / Q000473:pathology / Q000601:surgery*; D008297:Male; D011817:Rabbits; D014132:Trachea / Q000473:pathology / Q000601:surgery*