title: [Use of interferon-alpha (IFN-alpha) in the treatment of keratoacanthoma].
abstract: OBJECTIVE
  Keratoacanthoma are benign epithelial tumors. The aim of this study was to determine the effects of interferon alpha on keratoacanthoma.
  
  
  METHODS
  Six patients presented with histologically proven keratoacanthoma which were large or otherwise difficult to excise. Intra and perilesional interferon-alpha treatment with 3 million IU weekly was started.
  
  
  RESULTS
  In 6-15 weeks all tumors were cured.
  
  
  CONCLUSIONS
  Treatment with intralesional interferon-alpha offers a new possibility in cases of large keratoacanthomas, or those which are not surgically excisable.
authors.affiliation: Semmelweis Medizinische Universität, Klinik für Haut- und Geschlechtskrankheiten, Budapest, Ungarn.
authors.forename: B
authors.initials: B
authors.lastname: Somlai
authors.forename: P
authors.initials: P
authors.lastname: Holló
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D015552:Injections, Intralesional; D016898:Interferon-alpha / Q000008:administration & dosage*; D007636:Keratoacanthoma / Q000188:drug therapy*; D007868:Leg Dermatoses / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007155:Immunologic Factors; D016898:Interferon-alpha