Cerebellar abnormalities in mental illness. A study on Purkinje cell density in schizophrenic men.
The linear Purkinje cell density in the cerebellar vermis was investigated in a small cohort of adult onset schizophrenic men with well-documented hippocampal abnormalities. There were no differences in comparison with age-matched controls. This negative finding indicates that vermian abnormalities undoubtedly seen in some schizophrenic patients may constitute a subsyndrome, possibly related to autistic disorders in which cerebellar abnormalities are well corroborated.
Lingärde
B
B
Department of Clinical Neuroscience, University Hospital, Lund.
Jönsson
S A
SA
Luts
A
A
Brun
A
A
D000328:Adult; D017668:Age of Onset; D000368:Aged; D001321:Autistic Disorder / Q000175:diagnosis; D002452:Cell Count; D002531:Cerebellum / Q000166:cytology* / Q000473:pathology; D015331:Cohort Studies; D003937:Diagnosis, Differential; D006624:Hippocampus / Q000166:cytology / Q000473:pathology; D006801:Humans; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000473:pathology; D011149:Pons / Q000166:cytology / Q000473:pathology; D011689:Purkinje Cells / Q000166:cytology* / Q000473:pathology; D012559:Schizophrenia / Q000175:diagnosis* / Q000473:pathology