Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel.
Docetaxel (Taxotere), a semisynthetic taxoid, acts as an antimicrotubule agent and is considered to have great potential in the treatment of non-small cell lung cancer, advanced breast cancer, ovarian cancer and some other tumours. Well-recognized side-effects include dose-limiting neutropenia, fluid retention, myalgia, neuropathy, hypersensitivity reaction, alopecia, mucositis, nail changes and cutaneous reactions such as acral erythema. We describe a unique docetaxel-induced cutaneous reaction presenting as fixed erythematous plaque(s) unrelated to extravasation or previous skin injury; histopathological studies were performed in three of the four cases.
Chu
C Y
CY
Departments of Dermatology and Oncology, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.
Yang
C H
CH
Yang
C Y
CY
Hsiao
G H
GH
Chiu
H C
HC
D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D010292:Paresthesia / Q000139:chemically induced*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel