title: Risk assessment of renal cortical scarring with urinary tract infection by clinical features and ultrasonography.
abstract: OBJECTIVE
  To address some of the issues in the ongoing debate over the optimal diagnostic imaging following childhood urinary tract infection (UTI), by determining the risk of missing renal cortical scarring which would be detected on a technetium-99m dimercaptosuccinic acid (DMSA) gold standard if ultrasound alone were used, factoring for clinical features (upper or lower tract), UTI recurrence, and age group (infants, preschool, or school age).
  
  
  METHODS
  Details of UTI clinical features and recurrence were recorded for 990 children with a proven UTI, and their DMSA and ultrasound results were compared for each kidney.
  
  
  RESULTS
  The risks of missing DMSA scarring varied between 0.4% (school age children with solitary lower tract UTI) and 11.1% (infants with recurrent upper tract UTI).
  
  
  CONCLUSIONS
  UTI clinical features are important in assessing the need for DMSA imaging. Current UK imaging guidelines are endorsed, although preschool children with solitary lower tract UTI remain a controversial group and more attention needs to focused on children with recurrent UTI.
authors.affiliation: Renal Unit, Royal Hospital for Sick Children, Yorkhill, Glasgow G3 8SJ, Scotland, UK.
authors.forename: M T
authors.initials: MT
authors.lastname: Christian
authors.forename: J H
authors.initials: JH
authors.lastname: McColl
authors.forename: J R
authors.initials: JR
authors.lastname: MacKenzie
authors.forename: T J
authors.initials: TJ
authors.lastname: Beattie
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000000981:diagnostic imaging; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007223:Infant; D007672:Kidney Cortex / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D008297:Male; D011877:Radionuclide Imaging; D012008:Recurrence; D018570:Risk Assessment; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014463:Ultrasonography; D014552:Urinary Tract Infections / Q000000981:diagnostic imaging*
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid