title: Rectally administered dimenhydrinate reduces postoperative vomiting in children after strabismus surgery.
abstract: We have investigated the effectiveness of rectally administered dimenhydrinate on postoperative vomiting in children undergoing strabismus surgery, in a double-blind, randomized, placebo-controlled study. In one group, dimenhydrinate 50 mg was administered rectally 30 min before starting anaesthesia, whereas in the control group, placebo suppositories were given. Children who received dimenhydrinate showed a significantly (P < 0.001) lower incidence of vomiting (15%) than those in the control group (75%). We conclude that rectal administration of dimenhydrinate is an effective means of reducing postoperative vomiting in children undergoing strabismus surgery.
authors.affiliation: Department of Anaesthesia and Intensive Care Medicine, Leopold Franzens University of Innsbruck, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Schlager
authors.forename: G
authors.initials: G
authors.lastname: Mitterschiffthaler
authors.forename: F
authors.initials: F
authors.lastname: Pühringer
mesh_terms: D000285:Administration, Rectal; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004111:Dimenhydrinate / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011446:Prospective Studies; D013285:Strabismus / Q000601:surgery*
chemical_list: D000932:Antiemetics; D004111:Dimenhydrinate