A case of bilateral heel ulcers associated with hydroxyurea therapy for chronic myelogenous leukemia.
Bilateral heel skin ulcers developed in a 50-year-old male in the chronic phase of chronic myelogenous leukemia who had been receiving hydroxyurea (HU) therapy for 3 years. Histological examination showed perivascular lymphocytic inflammation without vasculitis. After interruption of HU administration, the heel ulcers were completely resolved within 2 months. The clinical course strongly suggested that the heel ulcers were induced by long-term HU therapy.
Tarumoto
T
T
Department of Hematology, Jichi Medical School, Tochigi, Japan.
Imagawa
S
S
Hotta
T
T
Ohmine
K
K
Nagai
T
T
Takatoku
M
M
Komatsu
N
N
Hatake
K
K
Ozawa
K
K
D000970:Antineoplastic Agents / Q000009:adverse effects*; D016523:Foot Ulcer / Q000139:chemically induced* / Q000473:pathology; D006365:Heel; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D006918:Hydroxyurea