[Toxic and enzymatic activities of the Bothrops moojeni venom from Argentina].
Toxic and enzymatic activity of Bothrops moojeni venom from Argentine. Hemorrhagic, edema forming, proteolytic and indirect hemolytic activities, myonecrosis and muscle regeneration using optic microscopy induced by Bothrops moojeni snake venom from Argentina were studied. The described activities were present in this venom. Myonecrosis was intense 60 minutes after venom injection, increasing its activity during the first 3 hours. Myolytic lesions rise above coagulative ones. Hemorrhage was minimum the same as the edema. After 3 hours polymorphonuclear inflammatory infiltrate was observed, with neutrophils. Macrophages were visible after 48 hours. After 3 days fibroblasts were present. At the 7 day muscle fiber regeneration were present, showing striations alternating with calcified areas. Bothrops moojeni venom injuries are intense and the recuperation of them can generate important tissue lose, with functional consequences.
Ruiz de Torrent
R
R
Cátedra de Patología Médica, Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, UNNE, Corrientes.
Acosta de Pérez
O
O
Teiblert
P
P
Maruñak
S
S
Koscinczuk
P
P
Sánchez Negrette
M
M
D000818:Animals; D001118:Argentina; D017837:Bothrops; D003435:Crotalid Venoms / Q000633:toxicity*; D004487:Edema / Q000139:chemically induced*; D006461:Hemolysis; D006470:Hemorrhage / Q000139:chemically induced*; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D009336:Necrosis; D010447:Peptide Hydrolases / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D012038:Regeneration
D003435:Crotalid Venoms; D010741:Phospholipases A; D010447:Peptide Hydrolases