Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype.
Heavy chain deposition disease (HCDD) is a rare entity characterized by tissue deposition of monoclonal heavy chains without light chains. Previous reports of HCDD include gamma(1)-, gamma(3)-, gamma(4)-, and alpha-heavy chain subtypes. Renal transplantation for HCDD has not been previously reported. We report a case of gamma(2)-HCDD in a 67-year-old patient who presented with proteinuria, hematuria, and renal insufficiency and progressed to end-stage renal failure after 6 months. The second case involves a 26-year-old woman who had a renal transplant for HCDD and recurrent gamma(1)-HCDD in the transplant. Neither patient had myeloma. The complete spectrum of gamma-HCDD subtypes has now been reported. Further data are required to make conclusive statements about the true recurrence rate of HCDD in renal transplants.
Herzenberg
A M
AM
Department of Pathology and Laboratory Medicine, St Paul's Hospital, Vancouver, BC, Canada.
Kiaii
M
M
Magil
A B
AB
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006362:Heavy Chain Disease / Q000145:classification / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007142:Immunoglobulin gamma-Chains / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology* / Q000473:pathology / Q000648:ultrastructure; D016030:Kidney Transplantation; D008854:Microscopy, Electron; D012008:Recurrence
D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains