title: Profile of neurologic disorders associated with HIV/AIDS from Bangalore, south India (1989-96).
abstract: One hundred patients (95 males, 5 females, mean age at presentation 31.6 +/- 9.4 yr) with various neurological disorders associated with HIV infection during 1989-1996 were evaluated at NIMHANS, Bangalore. Eighty patients belonged to group I associated with opportunistic neuroinfections and 20 to group II--non infectious neurological disorders. Cryptococcal meningitis either alone (n = 31) or associated with tuberculous meningitis (n = 6) was the most common (46.3%) followed by neurotuberculosis either alone (n = 24) or with cerebral toxoplasmosis (n = 4) accounting for 35 per cent. Other opportunistic neuroinfections included cerebral toxoplasmosis, herpes zoster, fulminant pyogenic meningitis and neurosyphilis. Clinical characteristics, diagnostic clues, their laboratory and radiological profiles and problems encountered in diagnosis and management of these opportunistic infections are highlighted. In group II (19 males and one female; mean age of 32.6 +/- 9.4 yr), two patients had cortical dementia, three acute brain stem involvement, two epilepsy and one had features suggestive of progressive multifocal leukoencephalopathy. Two patients of group I during follow up developed cortical dementia. Six had peripheral nervous system involvement similar to Guillain-Barre syndrome. Sixty six patients (63 of group I and 3 of group II) progressed to AIDS, 33 patients from group I and one patient from group II succumbed to the disease. With the rapid increase in the incidence of HIV/AIDS and an increase in the neurological manifestations of HIV/AIDS it is important to recognise the magnitude of the problem for health planning in India.
authors.affiliation: Department of Neurology, National Institute of Mental Health & Neuro Sciences, Bangalore.
authors.forename: P
authors.initials: P
authors.lastname: Satishchandra
authors.forename: A
authors.initials: A
authors.lastname: Nalini
authors.forename: M
authors.initials: M
authors.lastname: Gourie-Devi
authors.forename: N
authors.initials: N
authors.lastname: Khanna
authors.forename: V
authors.initials: V
authors.lastname: Santosh
authors.forename: V
authors.initials: V
authors.lastname: Ravi
authors.forename: A
authors.initials: A
authors.lastname: Desai
authors.forename: A
authors.initials: A
authors.lastname: Chandramuki
authors.forename: P N
authors.initials: PN
authors.lastname: Jayakumar
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000145:classification / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000145:classification / Q000453:epidemiology*