Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor.
[formula: see text] A mild and highly efficient cyclization of beta-hydroxy amides to oxazolines is described using DAST and Deoxo-Fluor reagents. A one-pot protocol for the synthesis of oxazoles from beta-hydroxy amides is also presented.
Phillips
A J
AJ
Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.
Uto
Y
Y
Wipf
P
P
Reno
M J
MJ
Williams
D R
DR
D004048:Diethylamines / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis*
D004048:Diethylamines; D007202:Indicators and Reagents; D010080:Oxazoles; D005461:Fluorine; C040394:diethylaminosulfur trifluoride