title: Synthesis of 2,2-diphenylpropionate derivatives and their effects on larval growth of the silkworm.
abstract: A variety of 2,2-diphenylpropionate derivatives with an amino substituent were synthesized and their effects on larval growth of the silkworm, Bombyx mori, were examined by dietary administration. Of the compounds tested, 3-(4-ethylpiperazin-1-yl)propyl 2,2-diphenylpropionate (3) caused significant prolongation of the larval period. Studies on the structure-activity relationship indicate that a piperazine ring and the bond distances between the nitrogen atom and the ester group were important for this activity. Treatment of compound 3 delayed the increase of ecdysteroid titers in the hemolymph by 3 days compared with that of the control, which correlates with the delay in molting.
authors.affiliation: Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, Fukuoka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Toyomura
authors.forename: I H
authors.initials: IH
authors.lastname: Kim
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: T
authors.initials: T
authors.lastname: Shiotsuki
authors.forename: E
authors.initials: E
authors.lastname: Kuwano
mesh_terms: D000818:Animals; D012831:Bombyx / Q000254:growth & development*; D007814:Larva / Q000254:growth & development; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010666:Phenylpropionates; C032371:2,2-diphenylpropionic acid