[Chemical modifications of macromolecules and their use in preparation of protein antitumor drug conjugates,vaccines and diagnostic reagents].
This article reviews high temperature glycation of proteins, and describes some applications of thus received neoglycoconjugates as vaccines or drug and gene carriers. The use of macromolecules: antibodies, fibrinogen and natural or synthetic polymers as antitumor drug carriers is discussed. Moreover the article presents method for monitoring of proteins modification by glutaraldehyde.
Boratyński
J
J
Zakład Immunologii Nowotworów, Instytutu Immunologii i Terapii Doświadczalnej PAN, Wrocławiu.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005976:Glutaral / Q000737:chemistry*; D006358:Hot Temperature; D006801:Humans; D007202:Indicators and Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D014612:Vaccines / Q000138:chemical synthesis* / Q000737:chemistry
D000970:Antineoplastic Agents; D004337:Drug Carriers; D007202:Indicators and Reagents; D011355:Prodrugs; D011506:Proteins; D014612:Vaccines; D005976:Glutaral