title: Xenogeneic patch closure of the small intestine: a novel approach to fistula management.
abstract: Previous work from our laboratory demonstrated the feasibility of utilizing placental-derived collagen tissue matrix (CTM) as a bowel wall substitute. We reasoned that this technique would also be suitable in managing intestinal fistulae. To test this hypothesis, we created a chronic cecal fistula in rats and randomly managed some with primary repair and others with CTM replacement. Leak rates, mortality, bursting pressures and histologic scores were similar, suggesting that a chronic fistula can be successfully managed with either a CTM or primary repair.
authors.affiliation: Department of Surgery, Washington Hospital Center, Washington, DC 20010, USA. jmk2@mhg.edu
authors.forename: J R
authors.initials: JR
authors.lastname: Kirkpatrick
authors.forename: W D
authors.initials: WD
authors.lastname: Nguyen
authors.forename: D H
authors.initials: DH
authors.lastname: Kim
authors.forename: T L
authors.initials: TL
authors.lastname: Fitzgerald
authors.forename: H S
authors.initials: HS
authors.lastname: Provido
authors.forename: H B
authors.initials: HB
authors.lastname: Alam
mesh_terms: D000818:Animals; D002429:Cecal Diseases / Q000503:physiopathology / Q000601:surgery*; D002432:Cecum / Q000503:physiopathology; D002908:Chronic Disease; D007412:Intestinal Fistula / Q000503:physiopathology / Q000601:surgery*; D007421:Intestine, Small / Q000637:transplantation*; D008297:Male; D009092:Mucous Membrane / Q000637:transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration; D013552:Swine; D014183:Transplantation, Heterologous