The sulfamate functional group as a new anchor for solid-phase organic synthesis
[reaction: see text] Sulfamate derivatives were loaded on trityl chloride resin, and two variants of cleavage were developed for this sulfamate anchor: an acid treatment to easily restore the free sulfamate and a nucleophilic treatment to generate the corresponding phenol. In addition to loading/cleavage assays and stability experiments, a model sequence of reactions was performed with the new sulfamate anchor to show its applicability in further combinatorial solid-phase synthesis of libraries of biologically relevant sulfamate derivatives.
Ciobanu
LC
Division of Medicinal Chemistry, Laval University Medical Research Center, CHUQ, Quebec, Canada.
Maltais
R
Poirier
D