Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature.
Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison syndrome. We report the case of an ovarian carcinoma showing increased plasma gastrin concentration. A 60-yr-old woman presented with epigastric pain and diarrhea. Physical examination showed a large mass in the lower abdomen. Computed tomography revealed a large multilocular ovarian cyst. Upper gastrointestinal endoscopy examination showed multiple ulcerations of the stomach and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were found in the pancreas and duodenum, and salpingo-oophorectomy was performed. Histologic examination revealed a mucinous tumor of borderline malignant potential. Immunoperoxidase studies for gastrin showed many gastrin-producing cells within the epithelium of the tumor. There have been 11 cases (including our patient) of gastrin-producing ovarian tumor reported in the literature. We review here the relevant literature. Although ovarian gastrinoma is extremely rare, it should be considered as a possible cause of the Zollinger-Ellison syndrome in women.
Hirasawa
K
K
Department of Pathology, Hamamatsu Medical Center, Shizuoka, Japan.
Yamada
M
M
Kitagawa
M
M
Takehira
Y
Y
Tamakoshi
K
K
Nakamura
T
T
Kawamura
K
K
Takagi
M
M
Murohisa
B
B
Ozawa
T
T
Hanai
H
H
Kaneko
E
E
D002288:Adenocarcinoma, Mucinous / Q000150:complications* / Q000378:metabolism; D005260:Female; D005755:Gastrins / Q000378:metabolism; D006729:Hormones, Ectopic / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism; D015043:Zollinger-Ellison Syndrome / Q000209:etiology*
D005755:Gastrins; D006729:Hormones, Ectopic