title: Ovarian mucinous cystadenocarcinoma as a cause of Zollinger-Ellison syndrome: report of a case and review of the literature.
abstract: Gastrin producing ovarian tumor is a rare cause of the Zollinger-Ellison syndrome. We report the case of an ovarian carcinoma showing increased plasma gastrin concentration. A 60-yr-old woman presented with epigastric pain and diarrhea. Physical examination showed a large mass in the lower abdomen. Computed tomography revealed a large multilocular ovarian cyst. Upper gastrointestinal endoscopy examination showed multiple ulcerations of the stomach and duodenum. The plasma gastrin level was 1500 pg/ml. No tumors were found in the pancreas and duodenum, and salpingo-oophorectomy was performed. Histologic examination revealed a mucinous tumor of borderline malignant potential. Immunoperoxidase studies for gastrin showed many gastrin-producing cells within the epithelium of the tumor. There have been 11 cases (including our patient) of gastrin-producing ovarian tumor reported in the literature. We review here the relevant literature. Although ovarian gastrinoma is extremely rare, it should be considered as a possible cause of the Zollinger-Ellison syndrome in women.
authors.affiliation: Department of Pathology, Hamamatsu Medical Center, Shizuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hirasawa
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takehira
authors.forename: K
authors.initials: K
authors.lastname: Tamakoshi
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Kawamura
authors.forename: M
authors.initials: M
authors.lastname: Takagi
authors.forename: B
authors.initials: B
authors.lastname: Murohisa
authors.forename: T
authors.initials: T
authors.lastname: Ozawa
authors.forename: H
authors.initials: H
authors.lastname: Hanai
authors.forename: E
authors.initials: E
authors.lastname: Kaneko
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications* / Q000378:metabolism; D005260:Female; D005755:Gastrins / Q000378:metabolism; D006729:Hormones, Ectopic / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000378:metabolism; D015043:Zollinger-Ellison Syndrome / Q000209:etiology*
chemical_list: D005755:Gastrins; D006729:Hormones, Ectopic