title: Brain MRI lesions and atrophy are related to depression in multiple sclerosis.
abstract: It is unclear whether brain MRI lesions are associated with depression in multiple sclerosis (MS). Neurological dysfunction in depressed (n= 19) and non-depressed (n = 29) MS patients was rated by expanded disability status scale (EDSS). EDSS was weakly predictive of the presence of (p = 0.03) and severity of (p = 0.01) depression. After correcting for EDSS, the presence of depression was predicted by superior frontal and superior parietal hypointense TI lesions (p<0.01); the severity of depression was predicted by superior frontal, superior parietal and temporal TI lesions, lateral and third ventricular enlargement, and frontal atrophy (p<0.01). Depression was not related to bright T2 lesions or enhancement. We conclude that atrophy and cortical-subcortical disconnection due to frontal and parietal white matter destructive lesions may contribute to depression in MS.
authors.affiliation: Department of Neurology, University at Buffalo (SUNY) School of Medicine and Biomedical Sciences, Buffalo General Hospital, NY 14203, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bakshi
authors.forename: D
authors.initials: D
authors.lastname: Czarnecki
authors.forename: Z A
authors.initials: ZA
authors.lastname: Shaikh
authors.forename: R L
authors.initials: RL
authors.lastname: Priore
authors.forename: V
authors.initials: V
authors.lastname: Janardhan
authors.forename: Z
authors.initials: Z
authors.lastname: Kaliszky
authors.forename: P R
authors.initials: PR
authors.lastname: Kinkel
mesh_terms: D000328:Adult; D001284:Atrophy / Q000209:etiology / Q000473:pathology; D003711:Demyelinating Diseases / Q000209:etiology / Q000473:pathology; D003863:Depression / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000473:pathology*; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000473:pathology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D020542:Third Ventricle / Q000473:pathology