title: Alcohol with xylocaine for treatment of eyelid dystonia.
abstract: Eyelid dystonia represents a form of idiopathic torsion dystonia, and it is considered as a rare disorder. Although botulinum toxin injections into the eyelids and eyebrows are considered by many neurologists as the treatment of choice for this, its cost limit its use in our community. A study was conducted at the King Hussein Medical Center between January 1995 and January 1998 using 1-2 ml of 0.5% xylocaine added to 99.5% ethanol in one-tenth of the volume of xylocaine, made injectable into the eyelids and eyebrows muscles in patients with blepharospasm. The treatment was aimed at reducing muscle spindle afferent activity. Twenty-one patients were given this modality of treatment in at least 8-12 separate sessions, with two weeks elapsing between any two sessions. Mild to moderate improvement was observed in 47.6% of our patients. The average latency from the time of the injection to the onset of improvement was 30-60 min and the average duration of improvement was 5-7 days. The commonest encountered side-effect was bruising at the site of injection that resolved spontaneously in less than 5 days. It is obvious that the usefulness of this treatment is limited by the substantially shorter duration of benefit, thus it cannot be considered as an alternative to Botox treatment. It may be useful to investigate whether a higher alcohol concentration is more effective.
authors.affiliation: Neurology Department, King Hussein Medical Center, Amman, Jordan. Anoud@hotmail.com
authors.forename: A F
authors.initials: AF
authors.lastname: Mubaidin
mesh_terms: D001764:Blepharospasm / Q000188:drug therapy; D004338:Drug Combinations; D004422:Dystonia Musculorum Deformans / Q000188:drug therapy*; D000431:Ethanol / Q000008:administration & dosage* / Q000009:adverse effects*; D005143:Eyelids / Q000187:drug effects*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D000431:Ethanol; D008012:Lidocaine