Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man.
Food-derived opioid peptides such as beta-casomorphins are of interest for treatment of chronic diarrhea. The beta-casomorphin analog casokefamide was administered orally at doses of 5.5, 8.0, and 16.0 mg to 10 healthy male volunteers, respectively. Dose-dependent increases of plasma levels with a maximum of 350 fmol/l were determined. No side-effects due to casokefamide has been observed. In comparison to placebo, casokefamide showed a trend toward prolongation of oro-caecal transit time. Orally applied casokefamide is well tolerated and may represent a useful tool for treatment of diarrhea in the future.
Schulte-Frohlinde
E
E
Department of Medicine II, Technical University of Munich, Ismaningerstrasse 22, 81675, Munich, Germany. Ewert.Schulte-Frohlinde@lrz.tu-muenchen.de
Reindl
W
W
Bierling
D
D
Lersch
C
C
Brantl
V
V
Teschemacher
H
H
Schusdziarra
V
V
D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D005772:Gastrointestinal Transit / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007457:Iodine Radioisotopes; D007792:Lactulose / Q000493:pharmacokinetics; D008297:Male; D010919:Placebos
D004723:Endorphins; D007457:Iodine Radioisotopes; D010919:Placebos; D007792:Lactulose; C047075:beta casomorphin 4027