Novel fungal metabolites, demethylsorbicillin and oxosorbicillinol, isolated from Trichoderma sp. USF-2690.
The novel compounds, demethylsorbicillin (1) and oxosorbicillinol (2), were isolated from a fermentation broth of Trichoderma sp. USF-2690. The structures of these compounds, which were determined from spectroscopic evidence, suggest the possibility that methylation at C-6 and oxidation at C-1 and C-6 of sorbicillin were controlled in the early polyketide stage before the formation of oxidized sorbicillin dimers. In a 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, 2 gave an ED50 value of 87.7 microM.
Abe
N
N
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Japan. abe@fns1.u-shizuoka-ken.ac.jp
Yamamoto
K
K
Hirota
A
A
D000900:Anti-Bacterial Agents / Q000032:analysis; D003512:Cyclohexanones / Q000032:analysis*; D006838:Hydrocarbons / Q000032:analysis; D015394:Molecular Structure; D012118:Resorcinols / Q000032:analysis*; D014242:Trichoderma / Q000737:chemistry* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003512:Cyclohexanones; D006838:Hydrocarbons; D012118:Resorcinols; C410946:desmethylsorbicillin; C410947:oxosorbicillinol