title: A method for the asymmetric hydrosilylation of N-aryl imines.
abstract: [reaction: see text] The asymmetric reduction of N-aryl imines to yield chiral amines with enantiomeric excesses above 90% was achieved. Ethylenebis(eta5-tetrahydroindenyl)titanium difluoride ((EBTHI)TiF2, 1) was employed as the precatalyst with polymethylhydrosiloxane (PMHS) as the stoichiometric reducing agent. A variety of N-aryl imines derived from nonaromatic ketones were reduced with high ee.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Hansen
authors.forename: S L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D007097:Imines / Q000737:chemistry*; D012833:Siloxanes / Q000737:chemistry*
chemical_list: D007097:Imines; D012833:Siloxanes; C402373:poly(methylhydrosiloxane)