title: Three families with polyneuropathy associated with monoclonal gammopathy.
abstract: OBJECTIVE
  To report familial occurrence of polyneuropathy associated with monoclonal gammopathy.
  
  
  METHODS
  Case reports.
  
  
  METHODS
  We describe 6 patients (3 pairs) with a polyneuropathy associated with IgM monoclonal gammopathy. Four of the 6 patients had a demyelinating polyneuropathy on neurophysiological examination. Three patients had elevated antibodies against myelin-associated glycoprotein. No duplication on chromosome 17 or a mutation on chromosome 1 was found in any family.
  
  
  CONCLUSIONS
  Familial occurrence of polyneuropathy without the presence of hereditary motor and sensory neuropathy type I is a reason to search for the presence of monoclonal gammopathy.
authors.affiliation: Department of Neuromuscular Disorders, Rudolf Magnus Institute of Neurosciences, Utrecht, The Netherlands.
authors.forename: S M
authors.initials: SM
authors.lastname: Manschot
authors.forename: N C
authors.initials: NC
authors.lastname: Notermans
authors.forename: L H
authors.initials: LH
authors.lastname: van den Berg
authors.forename: J J
authors.initials: JJ
authors.lastname: Verschuuren
authors.forename: H M
authors.initials: HM
authors.lastname: Lokhorst
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications* / Q000235:genetics / Q000276:immunology; D011115:Polyneuropathies / Q000209:etiology* / Q000235:genetics
chemical_list: D007074:Immunoglobulin G; D018992:Myelin-Associated Glycoprotein