title: Complex segregation analysis of deafness in Dalmatians.
abstract: OBJECTIVE
  To use pedigree analysis to evaluate the feasibility of a major locus model for deafness in Dalmatians.
  
  
  METHODS
  605 purebred Dalmatians from 42 families.
  
  
  METHODS
  Hearing loss was evaluated through the brainstem auditory-evoked response. Dogs were classified into mutually exclusive categories: normal hearing, unilaterally deaf, or bilaterally deaf. Information was collected on sex, coat color, presence or absence of a color patch at birth, and eye color. Statistical analyses were performed by use of regressive logistic models designed for complex segregation analysis. Genetic correlations among eye color, deafness, and color patch were estimated.
  
  
  RESULTS
  Prevalence of hearing loss was 11% for dogs classified as unilaterally deaf and 5% for dogs that were bilaterally deaf. Complex segregation analysis detected statistical evidence of a single allele with an expected frequency of 0.21 that had an effect on the prevalence of deafness. Results of analyses suggested that this locus cannot completely explain the inheritance and incidence of deafness in Dalmatians. Genetic correlation estimates among deafness, eye color, and color patch revealed strong interrelationships among these characteristics.
  
  
  CONCLUSIONS
  To reduce the incidence of hearing loss in Dalmatians, unilaterally deaf, blue-eyed dogs should not be considered as potential parents.
authors.affiliation: Department of Animal Science, College of Agriculture and Environmental Sciences, University of California, Davis 95616, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Famula
authors.forename: A M
authors.initials: AM
authors.lastname: Oberbauer
authors.forename: C A
authors.initials: CA
authors.lastname: Sousa
mesh_terms: D000483:Alleles; D000818:Animals; D002140:California / Q000453:epidemiology; D003638:Deafness / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000453:epidemiology / Q000235:genetics*; D004285:Dogs; D004423:Ear / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000235:genetics* / Q000502:physiology; D005127:Eye Color / Q000235:genetics; D005260:Female; D006200:Hair Color / Q000235:genetics; D019901:Locus Control Region; D016015:Logistic Models; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype; D015995:Prevalence; D012044:Regression Analysis; D012737:Sex Factors