Novel synthesis of the ocular age pigment A2-E: new method for substituted pyridine synthesis via azaelectrocyclization.
[reaction: see text] The formal synthesis of the ocular age pigment A2-E was achieved by the efficient one-pot preparation of the substituted pyridine, which involves the aza-6pi-electrocyclization of the Schiff base derived from (E)-3-carbonyl-2,4,6-trienal followed by oxidation.
Tanaka
K
K
School of Science, Kwansei Gakuin University, Hyogo, Japan.
Katsumura
S
S
D000375:Aging; D005136:Eye Proteins / Q000138:chemical synthesis / Q000737:chemistry; D012168:Retinal Pigments / Q000138:chemical synthesis / Q000737:chemistry*; D012176:Retinoids / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
C112040:A2-E (N-retinylidene-N-retinylethanolamine); D005136:Eye Proteins; D012168:Retinal Pigments; D012176:Retinoids