Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog.
A cutaneous melanocytoma-acanthoma in a 2-year-old female German Shepherd Dog was characterized by the presence of two populations of neoplastic cells: epithelial and melanocytic. The epithelial component consisted of nests of well-differentiated stratified squamous epithelium closely associated with neoplastic melanocytes. The epithelial cells immunoreacted with both monoclonal and polyclonal anti-cytokeratin antibodies, and immunoreaction to S-100 protein and vimentin was observed in the melanocytic cells. This rare pigmented skin neoplasm of the dog apparently has a benign behavior.
Espinosa de los Monteros
A
A
Martín de las Mulas
J
J
Fernández
A
A
Orós
J
J
Rodríguez
F
F
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007633:Keratins / Q000032:analysis; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000662:veterinary*; D018329:Nevus, Blue / Q000473:pathology / Q000662:veterinary*; D012878:Skin Neoplasms / Q000473:pathology / Q000662:veterinary*
D007633:Keratins