title: No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease.
abstract: We and others have previously identified two distinct haplotypes of the TAU gene in Caucasian populations. In this study, we have assessed whether these haplotypes show an association with Alzheimer's disease in a variety of populations. They do not. These data are consistent with the view that the involvement of TAU in Alzheimer's disease is a downstream event.
authors.affiliation: Neurogenetics Laboratories and Neurology Department, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
authors.forename: M
authors.initials: M
authors.lastname: Baker
authors.forename: D
authors.initials: D
authors.lastname: Graff-Radford
authors.forename: F
authors.initials: F
authors.lastname: Wavrant DeVrièze
authors.forename: N
authors.initials: N
authors.lastname: Graff-Radford
authors.forename: R C
authors.initials: RC
authors.lastname: Petersen
authors.forename: E
authors.initials: E
authors.lastname: Kokmen
authors.forename: B
authors.initials: B
authors.lastname: Boeve
authors.forename: L
authors.initials: L
authors.lastname: Myllykangas
authors.forename: T
authors.initials: T
authors.lastname: Polvikoski
authors.forename: R
authors.initials: R
authors.lastname: Sulkava
authors.forename: A
authors.initials: A
authors.lastname: Verkoniemmi
authors.forename: P
authors.initials: P
authors.lastname: Tienari
authors.forename: M
authors.initials: M
authors.lastname: Haltia
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: M
authors.initials: M
authors.lastname: Hutton
authors.forename: J
authors.initials: J
authors.lastname: Perez-Tur
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D011159:Population Surveillance; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology / Q000235:genetics / Q000473:pathology; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins