Effect of meropenem on the vascular permeability factor produced by Acinetobacter baumannii.
Eleven Acinetobacter baumannii strains produced a toxic substance--the vascular permeability factor--in the culture medium. Intradermal injection of this substance enhanced vascular permeability in the rabbit skin. The extent of permeability reactions varied from 0.28 cm2 to 1.61 cm2. Changes in the permeability factor activity of four A. baumannii strains after treatment with meropenem (CAS 96036-03-2) at suprainhibitory concentrations (2x, 4x or 8x) minimum inhibitory concentration (MIC) or supra-subinhibitory ones (2-8x MIC + 0.2x MIC) were tested in vitro. Meropenem at all suprainhibitory concentrations (with the exception of 8x MIC for one strain) was almost ineffective. Alterations in this activity were in the range of 93% to 106% of the control values. Supra-subinhibitory concentrations of meropenem significantly increased the permeability factor activity (to 150%-176% of the control values). These findings indicate that meropenem mainly at supra-subinhibitory concentrations can in vitro interfere with the vascular permeability factor produced by A. baumannii.
Hostacká
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Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
D000150:Acinetobacter / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D016228:Endothelial Growth Factors / Q000378:metabolism*; D008222:Lymphokines / Q000378:metabolism*; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D020033:Protein Isoforms / Q000378:metabolism*; D013845:Thienamycins / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D020033:Protein Isoforms; D013845:Thienamycins; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000077731:Meropenem