Local antithrombotic therapy using a novel porous balloon catheter.
The efficacy of local treatment of thrombosis with low-dose antithrombotic drugs (heparin: 30 U/kg, or argatroban: 0.02 mg/kg) was investigated using a novel porous balloon catheter. This novel balloon catheter can deliver drug into arterial walls without causing vascular trauma. Thrombus formation was significantly inhibited in balloon-injured and locally-treated iliac arteries compared with control balloon-injured arteries in 12 dogs. In the systemic high-dose delivery group (ten times as high as the low dose), thrombus formation in injured arteries was significantly less than that of controls in 7 dogs. Low-dose systemic delivery was not effective at inhibiting this thrombus formation. Thus, local treatment with an antithrombotic drug using this novel porous balloon catheter can prevent thrombosis without influencing systemic coagulability.
Tomaru
T
T
Department of Cardiology, Japanese Red Cross Medical Center, Tokyo.
Kobayakawa
N
N
Onitake
A
A
Nakamura
F
F
Morita
T
T
Uchida
Y
Y
D017546:Angioscopy; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives; D002404:Catheterization / Q000295:instrumentation*; D002406:Catheterization, Peripheral / Q000295:instrumentation*; D004285:Dogs; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006493:Heparin / Q000008:administration & dosage; D007083:Iliac Artery; D010875:Pipecolic Acids / Q000008:administration & dosage; D016062:Porosity; D013449:Sulfonamides; D015912:Thrombolytic Therapy / Q000295:instrumentation*; D013927:Thrombosis / Q000175:diagnosis / Q000188:drug therapy
D005343:Fibrinolytic Agents; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban