title: Immunoglobulins are effective in pontine myelinolysis.
abstract: Although the exact pathogenesis of central pontine myelinolysis (CPM) is unknown, correction of hyponatremia, thyreotropin releasing hormone, plasmapheresis, and corticosteroids seem to be effective. Assuming intravenous immunoglobulins (IVIG) to also be effective in CPM, 0.4 g/kg body weight/d immunoglobulins were applied to a 48-year-old patient who developed CPM with double vision, dysarthria, dysphagia, and left-sided hemiparesis 3 weeks after spontaneous normalization of hyponatremia. After 5 days of IVIG, his symptoms markedly improved, confirmed by improvement in the Norris score (42%), Frenchay score (19%), Kurtzke score (20%), Disability score (54%), vital capacity (26%), and peak torque (69%). The promising clinical effect of IVIG was assumed to be caused by the reduction of myelinotoxic substances, the development of antimyelin antibodies, and the promotion of remyelination. In conclusion, IVIG appear to be a promising therapeutic option in CPM.
authors.affiliation: Neurological Department, Neurological Hospital Rosenhügel, Vienna, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Finsterer
authors.forename: E
authors.initials: E
authors.lastname: Engelmayer
authors.forename: E
authors.initials: E
authors.lastname: Trnka
authors.forename: M
authors.initials: M
authors.lastname: Stiskal
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007167:Immunotherapy; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000000981:diagnostic imaging / Q000523:psychology / Q000628:therapy*; D009483:Neuropsychological Tests; D014057:Tomography, X-Ray Computed
chemical_list: D016756:Immunoglobulins, Intravenous