title: Dual effect of IL-4 on resistance to systemic gram-negative infection and production of TNF-alpha.
abstract: To determine the effect of interleukin 4 (IL-4) administration in a live sepsis model characterised by high-level production of tumour necrosis factor a (TNF-alpha), mice infected systemically with lethal or sublethal inocula of Pseudomonas aeruginosa were given the recombinant cytokine at different times before infection. Improved survival and decreased TNF-alpha production were observed in lethally infected mice treated with the cytokine 1 day before challenge. In contrast, increased mortality and overproduction of TNF-alpha were observed in sublethally infected mice given IL-4 at the time of infection.
authors.affiliation: Department of Experimental Medicine, University of Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Giampietri
authors.forename: U
authors.initials: U
authors.lastname: Grohmann
authors.forename: C
authors.initials: C
authors.lastname: Vacca
authors.forename: M C
authors.initials: MC
authors.lastname: Fioretti
authors.forename: P
authors.initials: P
authors.lastname: Puccetti
authors.forename: F
authors.initials: F
authors.lastname: Campanile
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004195:Disease Models, Animal; D018664:Interleukin-12 / Q000276:immunology / Q000494:pharmacology; D015847:Interleukin-4 / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D051379:Mice; D011552:Pseudomonas Infections / Q000276:immunology* / Q000517:prevention & control; D011550:Pseudomonas aeruginosa; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism; D018805:Sepsis / Q000276:immunology* / Q000517:prevention & control; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D018664:Interleukin-12; D015847:Interleukin-4