title: [Participation of multiresistant gram-negative rods in systemic infections of newborns treated in the Neonatal Clinics of the University Hospital in Krakow in 1993-1997].
abstract: Results of blood cultures in 1187 newborns hospitalized in the Department of Neonatology, University Hospital in Kraków in furing the last five years were analysed. A trial of monitoring the presence of multi-resistant strains of Enterobacteriaceae with new mechanisms of resistance to antibiotics as well as analysed of their antibiotics susceptibility patterns were undertaken. Surprisingly high percentage of Gram-negative rods E. cloacae and K. pneumoniae strains resistant to the 3rd generation of cephalosporins and participating in septic complications in the investigated hospital environment was demonstrated. There were identified 53 strains of Enterobacter sp., 35 strains of Klebsiella sp. and 3 strains of E. coli extremely resistant to ceftazidine, accounting for 72%, 56% and 5% of all isolated of the given kind, respectively. Dynamic increase in a number of multiresistant strains of K. pneumoniae from 11.1% of isolates in 1993 to 83% in 1997 was shown as well as remaining on a very high level frequency of isolation of Enterobacter sp. rods capable of producing chromosomal cephalosporinases was demonstrated. Full efficacy of carbapenems and high usefulness of ciprofloxacine in the treatment of infections were confirmed. The authors emphasize necessity for constant monitoring of susceptibility to antibiotics in resistant strains as well as for liquidating their sources and ways of their transmission.
authors.affiliation: Pracowni Bakteriologiczno-Serologicznej Szpitala Uniwersyteckiego w Krakowie.
authors.forename: J
authors.initials: J
authors.lastname: Kedzierska
authors.forename: M
authors.initials: M
authors.lastname: Dolezal
authors.forename: P
authors.initials: P
authors.lastname: Kachlik
mesh_terms: D003428:Cross Infection / Q000382:microbiology / Q000517:prevention & control; D018432:Drug Resistance, Multiple; D004755:Enterobacteriaceae / Q000145:classification* / Q000187:drug effects*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy* / Q000382:microbiology*; D006785:Hospitals, University; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy* / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009359:Neonatology / Q000379:methods; D011044:Poland; D013045:Species Specificity