Membrane cytoskeleton: PIP(2) pulls the strings.
A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.
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Department of Cell Biology, University of Massachusetts Medical School, Worcester, 01605, USA.
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Luna
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D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D051966:Phospholipase C gamma; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010738:Type C Phospholipases / Q000378:metabolism
D007527:Isoenzymes; D019269:Phosphatidylinositol 4,5-Diphosphate; D010744:Phosphoric Monoester Hydrolases; D010738:Type C Phospholipases; D051966:Phospholipase C gamma; D002118:Calcium