Structure of the reovirus core at 3.6 A resolution.
The reovirus core is an assembly with a relative molecular mass of 52 million that synthesizes, modifies and exports viral messenger RNA. Analysis of its structure by X-ray crystallography shows that there are alternative, specific and completely non-equivalent contacts made by several surfaces of two of its proteins; that the RNA capping and export apparatus is a hollow cylinder, which probably sequesters its substrate to ensure completion of the capping reactions; that the genomic double-stranded RNA is coiled into concentric layers within the particle; and that there is a protein shell that appears to be common to all groups of double-stranded RNA viruses.
Reinisch
K M
KM
Harvard University, Cambridge, Massachusetts 02138, USA.
Nibert
M L
ML
Harrison
S C
SC
D002213:Capsid / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D011487:Protein Conformation; D012315:RNA Caps; D012330:RNA, Double-Stranded / Q000737:chemistry; D012367:RNA, Viral / Q000737:chemistry; D012087:Reoviridae / Q000737:chemistry*
D012315:RNA Caps; D012330:RNA, Double-Stranded; D012367:RNA, Viral