title: Activities of taurolidine in vitro and in experimental enterococcal endocarditis.
abstract: In vitro, the antimicrobial agent taurolidine inhibited virtually all of the bacteria tested, including vancomycin-resistant enterococci, oxacillin-resistant staphylococci, and Stenotrophomonas maltophilia, at concentrations between 250 and 2,000 microg/ml. Taurolidine was not effective in experimental endocarditis. While it appears unlikely that this antimicrobial would be useful for systemic therapy, its bactericidal activity and the resistance rates found (<10(-9)) are favorable indicators for its possible development for topical use.
authors.affiliation: Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.
authors.forename: C
authors.initials: C
authors.lastname: Torres-Viera
authors.forename: C
authors.initials: C
authors.lastname: Thauvin-Eliopoulos
authors.forename: M
authors.initials: M
authors.lastname: Souli
authors.forename: P
authors.initials: P
authors.lastname: DeGirolami
authors.forename: M G
authors.initials: MG
authors.lastname: Farris
authors.forename: C B
authors.initials: CB
authors.lastname: Wennersten
authors.forename: R D
authors.initials: RD
authors.lastname: Sofia
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects*; D020615:Stenotrophomonas maltophilia / Q000187:drug effects*; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013829:Thiadiazines / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine; D010068:Oxacillin