[Effector action of ethanol on the accumulation of Ca2+ in intracellular structures of uterine smooth muscle].
The work is devoted to the investigation of ethanol direct effect on the transmembrane Ca2+ metabolism in the intracellular structures of myometrium. In the experiments in vitro it has been shown that the Mg2+, ATP-dependent system for Ca2+ accumulation in endoplasmic reticulum is more sensitive then Ca(2+)-accumulating system in mitochondria. It has also been found that the oxytocin insensitive part of Mg2+, ATP-dependent Ca2+ accumulation of the endoplasmic reticulum is less resistant to ethanol inhibition than the oxytocin sensitive one. The data above revealed allow to discuss mechanism of ethanol action on the intracellular Ca2+ homeostasis in myometrium.
Borisova
L A
LA
A.V. Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Kyiv.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006706:Homeostasis; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
D000431:Ethanol; D002118:Calcium