title: Tretinoin and cutaneous photoaging. Guaranteed adverse effects!
abstract: * A cream containing 0.05% tretinoin (Retinova((R)) is approved for treatment of sun-induced skin damage ("photoaging").* Three trials comparing tretinoin with the excipient show that the effects of tretinoin cream are at best limited and slow to occur. Furthermore, they disappear on treatment cessation, necessitating long-term use.* The 0.05% tretinoin cream has poor local tolerability: most subjects develop irritation and fragile skin and require longer intervals between each application. Systemic adverse effects occur in some circumstances.* There are persistent doubts about whether it is safe to use tretinoin during pregnancy.
mesh_terms: D002986:Clinical Trials as Topic; D003358:Cosmetics; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009824:Ointments; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D003358:Cosmetics; D007641:Keratolytic Agents; D009824:Ointments; D014212:Tretinoin