Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice.
Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of androgens into estrogen and, thereafter, through stimulation of estrogen receptors (ERs). The relative importance of ER subtypes in the regulation of the male skeleton was studied in ERalpha-knockout (ERKO), ERbeta-knockout (BERKO), and double ERalpha/beta-knockout (DERKO) mice. ERKO and DERKO, but not BERKO, demonstrated decreased longitudinal as well as radial skeletal growth associated with decreased serum levels of insulin-like growth factor I. Therefore, ERalpha, but not ERbeta, mediates important effects of estrogen in the skeleton of male mice during growth and maturation.
Vidal
O
O
Department of Internal Medicine, Division of Endocrinology, Sahlgrenska University Hospital, S-41345 Göteborg, Sweden.
Lindberg
M K
MK
Hollberg
K
K
Baylink
D J
DJ
Andersson
G
G
Lubahn
D B
DB
Mohan
S
S
Gustafsson
J A
JA
Ohlsson
C
C
D000818:Animals; D015519:Bone Density; D001846:Bone Development / Q000235:genetics / Q000502:physiology*; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005260:Female; D005838:Genotype; D006132:Growth Plate / Q000254:growth & development*; D006579:Heterozygote; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011960:Receptors, Estrogen / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D012727:Sex Characteristics; D013977:Tibia / Q000254:growth & development
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen; D007334:Insulin-Like Growth Factor I