title: Pediatric acoustic schwannoma showing rapid regrowth with high proliferative activity.
abstract: Acoustic schwannoma is a slow-growing tumor and usually occurs in adult patients. We report a rare pediatric case of acoustic schwannoma with high proliferative potential. A 10-year-old boy was diagnosed as having a right cerebellopontine angle tumor. The tumor was subtotally resected. Histological examination revealed a typical acoustic schwannoma with a few mitotic figures. Chromosomal analysis showed no abnormality on the long arm of chromosome 22 associated with neurofibromatosis type 2. The lesion re-grew rapidly as an acoustic schwannoma, necessitating subtotal resection on three occasions and CyberKnife radiosurgery. The immunohistochemical MIB-1 staining indices of the specimens obtained at the first, second, and third operations were 2.3%, 4.6% and 14.7%, respectively. The immunohistochemical proliferative potential of acoustic schwannoma is discussed.
authors.affiliation: Department of Neurosurgery, Yamaguchi University School of Medicine, Kogushi, Ube, Japan. kharada@po.cc.yamaguchi-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Harada
authors.forename: T
authors.initials: T
authors.lastname: Nishizaki
authors.forename: N
authors.initials: N
authors.lastname: Adachi
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Ito
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D002528:Cerebellar Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D002530:Cerebellopontine Angle / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D002648:Child; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009464:Neuroma, Acoustic / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor