Effects of genetic and diet-induced obesity on lipid metabolism.
C57BL/6J obese (ob/ob) and lean mice fed ad libitum on a normal mouse chow diet (Normal), were compared with lean mice of the same age and strain fed ad libitum on a high-fat diet, consisting of the Normal diet with the addition of beef lard (Lard), from age 3 months for 34 days. The lard-fed mice were seen to have significantly higher (P<0.05) body weight in this 34-day period than that of the other two groups fed on the Normal diet. Epididymal fat depot and adipocyte cell size were significantly larger (P<0.05) in the Lard-fed lean mice and in the obese (ob/ob) mice than were those of the Normal-fed lean mice. Dietary Lard intake did not significantly affect concentrations of plasma triglyceride although those of plasma cholesterol were significantly increased (P<0.05). The development of obesity in these Lard-fed mice appeared to be accelerated and significant.
Libinaki
R
R
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Heffernan
M
M
Jiang
W J
WJ
Ogru
E
E
Ignjatovic
V
V
Gianello
R
R
Trickey
L
L
Taylor
M
M
Ng
F
F
D017667:Adipocytes / Q000166:cytology / Q000473:pathology; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002417:Cattle; D002784:Cholesterol / Q000097:blood*; D004041:Dietary Fats; D008066:Lipolysis; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood*; D015430:Weight Gain
D004041:Dietary Fats; D014280:Triglycerides; D002784:Cholesterol; C029310:lard