title: Multifactorial analyses in the diagnosis of pneumonia arising in the surgical intensive care unit.
abstract: The diagnosis of ventilator-associated pneumonia in the surgical intensive care unit continues to be problematic. The majority of intensive care units use clinical criteria based on chest x-ray; fever; leukocytosis; alterations in the pulse oximeter observations; the need to alter modes and amounts of ventilatory support; and more specific microbiologic studies, such as appropriate sputum, Gram stain, and culture to identify pneumonia. Diagnosing pneumonia based on clinical criteria alone is often difficult and inaccurate, which may lead to inappropriate use and choice of antibiotics. Invasive diagnostic techniques, such as protected specimen brush and bronchoalveolar lavage, provide an important microbiologic diagnosis. However, the cost and inconvenience limit broad usage. Furthermore, those results that return positive are often too late to dictate the need for, or direction of, therapy. Our use of a "pneumonia grid" may help identify patients likely to have a poor outcome. Until a readily available and cost-effective diagnostic study for pneumonia is developed, clinical criteria remain vital in routine practice.
authors.affiliation: Department of Surgery and the Price Institute of Surgical Research, University of Louisville School of Medicine, Louisville, Kentucky, USA.
authors.forename: H C
authors.initials: HC
authors.lastname: Polk
authors.forename: N N
authors.initials: NN
authors.lastname: Mizuguchi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007362:Intensive Care Units; D011015:Pneumonia, Aspiration / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012121:Respiration, Artificial / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents