[Comparison of the influence of celiprolol, metoprolol and atenolol on pulmonary ventilation in patients with asthma].
Usage of beta-blocking agents in patients with bronchial asthma is restricted due to their ability to precipitate bronchospasm. Celiprolol beta1-selective beta-blocker with associated beta2-agonist activity gives brand new possibilities of treatment with beta-blockers in asthmatics. The aim of the study was to compare the pulmonary effects of single dose of celiprolol (200 mg), atenololol (25 mg), metoprolol (50 mg) and placebo. Ten stable asthmatic patients, aged 21-60 years (mean age 44.1 yrs.) were studied. During four separate visits with 3 days wash-out period physical examination, ECG recordings were done and lung function tests (FEV1, FVC, FEF25-75), blood pressure, heart rate and saturation were recorded. All parameters were measured again after 45, 90, 150 and 210 minutes from the beginning of the visit. On the contrary to metoprolol and atenolol single dose of celiprolol and placebo did not significantly affect respiratory functions (FVC--area under curve). There was significant decrease of FEV1 calculated as area under curve (AUC) after application of metoprolol in comparison to celiprolol. There were no significant changes in FEV1 after use of atenolol and celiprolol. Celiprolol ian dose 200 mg can be safely used in asthmatic patients.
Szmidt
M
M
II Kliniki Gruźlicy i Chorób Płuc Instytutu Gruźlicy i Chorób Płuc w Warszawie.
Minc
P
P
Wasiak
W
W
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D019540:Area Under Curve; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology*; D001262:Atenolol / Q000494:pharmacology*; D017272:Celiprolol / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D012123:Pulmonary Ventilation / Q000187:drug effects*
D000319:Adrenergic beta-Antagonists; D001262:Atenolol; D017272:Celiprolol; D008790:Metoprolol