title: Concomitant radiotherapy and chemotherapy for early-stage nasopharyngeal carcinoma.
abstract: OBJECTIVE
  Early-stage nasopharyngeal carcinoma (NPC) continues to carry a failure rate of 15% to 30% when treated with radiotherapy alone; the benefit of concomitant radiotherapy and chemotherapy (CCRT) in early-stage NPC is unclear. The purpose of this report is to describe our efforts to improve treatment outcome in early-stage NPC after CCRT.
  
  
  METHODS
  Of 189 newly diagnosed NPC patients without evidence of distant metastases who were treated in our institution between 1990 and 1997, 44 presented with early-stage (stage I and II) disease according to the American Joint Committee on Cancer (AJCC) 1997 NPC staging system. Twelve of these patients were treated with radiotherapy alone and 32 with CCRT. Each patient's head and neck area was evaluated by magnetic resonance imaging or computed tomography. Radiotherapy was administered at 2 Gy per fraction per day, Monday through Friday, for 35 fractions for a total dose of 70 Gy. Chemotherapy consisting of cis-diamine-dichloroplatinum and fluorouracil was delivered simultaneously with radiotherapy in weeks 1 and 6 and sequentially for two monthly cycles after radiotherapy.
  
  
  RESULTS
  Patients who were treated with radiotherapy alone primarily had stage I disease, whereas none of those who were treated with CCRT had stage I disease (11 of 12 patients v none of 32 patients; P =.001). The locoregional control rate at 3 years for the radiotherapy group was 91.7% (median follow-up period, 34 months) and was 100% for the CCRT group (median follow-up period, 44 months) (P =.10). The 3-year disease-free survival rate in the radiotherapy group was 91.7% and was 96.9% in the CCRT group (P =.66).
  
  
  CONCLUSIONS
  Our results reveal excellent prognosis of AJCC 1997 stage II NPC treated with CCRT. Stage II patients with a greater tumor burden treated with CCRT showed an equal disease-free survival, compared with stage I patients treated with radiotherapy alone. A prospective randomized trial is underway to confirm the role of CCRT in stage II NPC.
authors.affiliation: Departments of Radiation Oncology, Research, Head and Neck Surgery, Medical Oncology, and Radiology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan. skye@mail.kfcc.org.tw
authors.forename: S H
authors.initials: SH
authors.lastname: Cheng
authors.forename: S Y
authors.initials: SY
authors.lastname: Tsai
authors.forename: K L
authors.initials: KL
authors.lastname: Yen
authors.forename: J J
authors.initials: JJ
authors.lastname: Jian
authors.forename: N M
authors.initials: NM
authors.lastname: Chu
authors.forename: K Y
authors.initials: KY
authors.lastname: Chan
authors.forename: T D
authors.initials: TD
authors.lastname: Tan
authors.forename: J C
authors.initials: JC
authors.lastname: Cheng
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsieh
authors.forename: A T
authors.initials: AT
authors.lastname: Huang
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000532:radiotherapy*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil