Pleomorphic xanthoastrocytoma derived from glioneuronal malformation in a child with intractable epilepsy.
Malformative lesions as well as neoplasms can cause intractable epilepsy in childhood. Even though the neoplastic nature of a lesion is evident in most cases, the distinction can be difficult in some patients. We present the case of a child with intractable epilepsy caused primarily by a glioneuronal malformation. Years after the first surgical intervention, a pleomorphic xanthoastrocytoma evolved from remnants of this lesion. This case suggests that glioneuronal malformations might be precursor lesions of pleomorphic xanthoastrocytomas.
Ramelli
G P
GP
Department of Pediatrics, Institute of Pathology, University of Berne, Switzerland.
von der Weid
N
N
Remonda
L
L
Mariani
L
L
Weis
J
J
D001254:Astrocytoma / Q000150:complications* / Q000209:etiology; D001927:Brain Diseases / Q000150:complications / Q000151:congenital*; D001932:Brain Neoplasms / Q000150:complications* / Q000209:etiology; D004827:Epilepsy / Q000209:etiology*; D006801:Humans; D007223:Infant; D008297:Male; D009457:Neuroglia / Q000473:pathology*