Mechanisms of perinatal brain injury.
This article is focused on the mechanisms underlying primarily ischaemic/reperfusion brain injury in both the term and premature infant. Although the mechanisms involved include similar initiating events, principally ischaemia-reperfusion, and similar final common pathways to cell death, particularly free radical-mediated events, there are certain unique maturational factors influencing the type and pattern of cellular injury. We will therefore initially describe the physiological and cellular/molecular mechanisms of brain injury in the term infant, followed by the mechanisms in the premature infant.
Inder
T E
TE
Department of Paediatrics, Christchurch School of Medicine and Hospital, University of Otago, Christchurch, New Zealand.
Volpe
J J
JJ
D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D001930:Brain Injuries / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D016923:Cell Death; D002544:Cerebral Infarction / Q000150:complications; D002552:Cerebral Ventricles; D005260:Female; D005311:Fetal Hypoxia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D005609:Free Radicals / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000150:complications; D009474:Neurons / Q000166:cytology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D015427:Reperfusion Injury / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology / Q000517:prevention & control; D012307:Risk Factors
D005609:Free Radicals