title: Palladium-catalyzed intermolecular coupling of aryl halides and amides.
abstract: [formula: see text] The first general intermolecular C-N bond-forming reactions between aryl halides and amides were realized using a palladium catalyst with Xantphos as the ligand. Aryl triflates, carbamates, and sulfonamides are also viable substrates for the amidations, which proceed at 45-110 degrees C with 1-4 mol% of Pd catalyst in 66-99% yields and exhibit good functional group compatibility.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yin
authors.forename: S L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D002849:Chromatography, Gas; D006219:Halogens / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D006219:Halogens; D010165:Palladium