title: Effects of genetic and diet-induced obesity on lipid metabolism.
abstract: C57BL/6J obese (ob/ob) and lean mice fed ad libitum on a normal mouse chow diet (Normal), were compared with lean mice of the same age and strain fed ad libitum on a high-fat diet, consisting of the Normal diet with the addition of beef lard (Lard), from age 3 months for 34 days. The lard-fed mice were seen to have significantly higher (P<0.05) body weight in this 34-day period than that of the other two groups fed on the Normal diet. Epididymal fat depot and adipocyte cell size were significantly larger (P<0.05) in the Lard-fed lean mice and in the obese (ob/ob) mice than were those of the Normal-fed lean mice. Dietary Lard intake did not significantly affect concentrations of plasma triglyceride although those of plasma cholesterol were significantly increased (P<0.05). The development of obesity in these Lard-fed mice appeared to be accelerated and significant.
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Libinaki
authors.forename: M
authors.initials: M
authors.lastname: Heffernan
authors.forename: W J
authors.initials: WJ
authors.lastname: Jiang
authors.forename: E
authors.initials: E
authors.lastname: Ogru
authors.forename: V
authors.initials: V
authors.lastname: Ignjatovic
authors.forename: R
authors.initials: R
authors.lastname: Gianello
authors.forename: L
authors.initials: L
authors.lastname: Trickey
authors.forename: M
authors.initials: M
authors.lastname: Taylor
authors.forename: F
authors.initials: F
authors.lastname: Ng
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000473:pathology; D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D002417:Cattle; D002784:Cholesterol / Q000097:blood*; D004041:Dietary Fats; D008066:Lipolysis; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood*; D015430:Weight Gain
chemical_list: D004041:Dietary Fats; D014280:Triglycerides; D002784:Cholesterol; C029310:lard