[Nitric oxide storage in rats of various genetic strains and its role in the antistressor effect of adaptation to hypoxia].
Adaptation to hypobaric hypoxia induced a gradual increase in the NO production along with a progressive NO storage in vascular wall. Unadapted August rats were more resistant against stress-induced stomach ulceration than the Wistar rats. Following a 6-day adaptation rats of both strains revealed a protective antiulcerogenic effect. A long-term adaptation potentiated the stress damage of the stomach rather than protected against it. A higher basal NO production seems to provide a more efficient antistress defence in the August rats. An intense NO storage may create a relative NO shortage and thus predispose to stress-induced vasoconstriction and ulceration.
Pshennikova
M G
MG
Research Institute of General Pathology and Pathophysiology of the Russian Acad. Med. Sci., Moscow, Russia.
Smirin
B V
BV
Bondarenko
O N
ON
Malyshev
I Iu
IIu
Manukhina
E B
EB
D000222:Adaptation, Physiological; D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D008297:Male; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism*; D009573:Nitrites / Q000097:blood; D010100:Oxygen / Q000494:pharmacology*; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology; D013315:Stress, Psychological / Q000097:blood / Q000150:complications / Q000378:metabolism*; D013997:Time Factors
D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D010100:Oxygen