title: Sir2 links chromatin silencing, metabolism, and aging.
authors.affiliation: Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts 02139 USA. leng@mit.edu
authors.forename: L
authors.initials: L
authors.lastname: Guarente
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D002843:Chromatin / Q000235:genetics*; D005786:Gene Expression Regulation; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008660:Metabolism; D009243:NAD / Q000378:metabolism; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins; D015534:Trans-Activators / Q000378:metabolism*
chemical_list: D002843:Chromatin; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D015534:Trans-Activators; D009243:NAD; C087778:SIR2 protein, S cerevisiae; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases