title: When false recognition is unopposed by true recognition: gist-based memory distortion in Alzheimer's disease.
abstract: The authors examined false recognition of semantic associates in patients with probable Alzheimer's disease (AD), older adults, and young adults using a paradigm that provided rates of false recognition after single and multiple exposures to word lists. Using corrected false recognition scores to control for unrelated false alarms, the authors found that (a) the level of false recognition after a single list exposure was lower in AD patients than in controls; (b) across 5 trials, false recognition increased in AD patients, decreased in young adults, and showed a fluctuating pattern in older adults; and (c) all groups showed an increase in true recognition over the 5 trials. Analyses suggested that AD patients built up semantic gist across trials, whereas both control groups were able to use increased item-specific recollection and more conservative response criteria to suppress gist-based false alarms.
authors.affiliation: Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, Department of Psychology, Harvard University, and Harvard Medical School, Boston, Massachusetts 02115, USA. abudson@yahoo.com
authors.forename: A E
authors.initials: AE
authors.lastname: Budson
authors.forename: K R
authors.initials: KR
authors.lastname: Daffner
authors.forename: R
authors.initials: R
authors.lastname: Desikan
authors.forename: D L
authors.initials: DL
authors.lastname: Schacter
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D000704:Analysis of Variance; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D017603:Signal Detection, Psychological; D014936:Word Association Tests