Amplification of the ABC transporter gene PGPA and increased trypanothione levels in potassium antimonyl tartrate (SbIII) resistant Leishmania tarentolae.
Haimeur
A
A
Centre de Recherche en Infectiologie du Centre de Recherche du CHUL and Division de Microbiologie, Faculté de Médecine, Université Laval, 2705 boul. Laurier, Ste-Foy, Canada.
Brochu
C
C
Genest
P
P
Papadopoulou
B
B
Ouellette
M
M
D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000818:Animals; D000966:Antimony Potassium Tartrate / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D018053:Arsenites / Q000494:pharmacology; D004351:Drug Resistance / Q000235:genetics; D005784:Gene Amplification; D017125:Genes, Protozoan; D005978:Glutathione / Q000031:analogs & derivatives* / Q000378:metabolism; D007891:Leishmania / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics*; D015800:Protozoan Proteins; D013095:Spermidine / Q000031:analogs & derivatives* / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D000981:Antiprotozoal Agents; D018053:Arsenites; D008562:Membrane Glycoproteins; C106891:PgpA protein, Leishmania; D015800:Protozoan Proteins; C044809:trypanothione; D000966:Antimony Potassium Tartrate; D005978:Glutathione; C015001:arsenite; D013095:Spermidine