title: Treatment of HIV disease in the new millennium.
abstract: Highly active antiretroviral therapy (HAART), which typically consists of 3-drug combinations of antiretroviral agents, has decreased dramatically the incidence of AIDS and death among HIV-infected persons in the United States. HIV infection no longer is viewed as a death sentence. Complete suppression of viral replication through the use of HAART can reverse the immune deficits formerly thought to be inevitable. However, drug toxicity, cross-resistance, and less-than-perfect adherence to prescribed antiretroviral regimens make the medical management of the HIV-infected person complex. An overview of the current approach to antiretroviral therapy is presented in this article.
authors.affiliation: Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.
authors.forename: V
authors.initials: V
authors.lastname: Kak
authors.forename: R D
authors.initials: RD
authors.lastname: MacArthur
authors.forename: L R
authors.initials: LR
authors.lastname: Crane
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006678:HIV / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission / Q000821:virology; D006801:Humans; D019562:Viral Load; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents