Phospholipid biosynthesis in the yeast Saccharomyces cerevisiae and interrelationship with other metabolic processes.
In this review, we have discussed recent progress in the study of the regulation that controls phospholipid metabolism in S. cerevisiae. This regulation occurs on multiple levels and is tightly integrated with a large number of other cellular processes and related metabolic and signal transduction pathways. Progress in deciphering this complex regulation has been very rapid in the last few years, aided by the availability of the sequence of the entire Saccharomyces genome. The assignment of functions to the remaining unassigned open reading frames, as well as ascertainment of remaining gene-enzyme relationships in phospholipid biosynthesis in yeast, promises to provide detailed understanding of the genetic regulation of a crucial area of metabolism in a key eukaryotic model system. Since the processes of lipid metabolism, secretion, and signal transduction show fundamental similarities in all eukaryotes, the dissection of this regulation in yeast promises to have wide application to our understanding of metabolic control in all eukaryotes.
Carman
G M
GM
Department of Food Science, Cook College, New Jersey Agricultural Experiment Station, Rutgers University, New Brunswick 08901, USA. carman@aesop.rutgers.edu
Henry
S A
SA
D010717:CDPdiacylglycerol-Serine O-Phosphatidyltransferase / Q000378:metabolism; D002262:Carboxy-Lyases / Q000378:metabolism; D002797:Choline Kinase / Q000378:metabolism; D003565:Cytidine Diphosphate / Q000031:analogs & derivatives / Q000378:metabolism; D003566:Cytidine Diphosphate Choline / Q000378:metabolism; D003567:Cytidine Diphosphate Diglycerides / Q000378:metabolism; D002798:Diacylglycerol Cholinephosphotransferase / Q000378:metabolism; D004983:Ethanolamines / Q000378:metabolism; D008780:Methyltransferases / Q000378:metabolism; D019884:Nitrogenous Group Transferases / Q000378:metabolism; D050918:Phosphatidylethanolamine N-Methyltransferase; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D003567:Cytidine Diphosphate Diglycerides; D004983:Ethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; C006933:CDP ethanolamine; D003566:Cytidine Diphosphate Choline; D003565:Cytidine Diphosphate; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase; D019884:Nitrogenous Group Transferases; D017853:Phosphotransferases (Alcohol Group Acceptor); D002797:Choline Kinase; C020125:ethanolamine kinase; C022370:phospholipid serine base exchange enzyme; D002798:Diacylglycerol Cholinephosphotransferase; D010717:CDPdiacylglycerol-Serine O-Phosphatidyltransferase; D002262:Carboxy-Lyases; C022353:phosphatidylserine decarboxylase