N-Arylation of Sulfonamides on Solid Supports.
A general and mild method for the N-arylation of sulfonamides on solid supports is reported. Copper acetate, triethylamine mediated coupling of arylboronic acids at room temperature to solid-supported sulfonamides gave good to excellent yields of the desired N-arylsulfonamides. Sulfonamide bond cleavage of the o,p-dinitrobenzene(N-aryl)sulfonamide provides a route to N-arylated secondary amine products.
Combs
AP
Chemical and Physical Sciences Department, DuPont Pharmaceuticals Company, Experimental Station, P.O. Box 80500, Wilmington, Delaware 19880-0500.
Rafalski
M