Palladium-catalyzed intermolecular coupling of aryl halides and amides.
[formula: see text] The first general intermolecular C-N bond-forming reactions between aryl halides and amides were realized using a palladium catalyst with Xantphos as the ligand. Aryl triflates, carbamates, and sulfonamides are also viable substrates for the amidations, which proceed at 45-110 degrees C with 1-4 mol% of Pd catalyst in 66-99% yields and exhibit good functional group compatibility.
Yin
J
J
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Buchwald
S L
SL
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D002849:Chromatography, Gas; D006219:Halogens / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
D000577:Amides; D006219:Halogens; D010165:Palladium