title: Radical excision of multifocal anal intraepithelial neoplasia: report of a case.
abstract: OBJECTIVE
  The aim of this study was to describe the technique of radical excision of multifocal anal intraepithelial neoplasia and discuss controversial issues surrounding the management of this condition.
  
  
  METHODS
  We describe the case of a 31-year-old female with previous vulval warts, vulval squamous carcinoma, and recent immunosuppression who had widespread anal intraepithelial neoplasia excised, and the resulting defect was split-skin grafted, including the anal canal.
  
  
  RESULTS
  Excision and split-skin grafting was successful in removing the disease and left a satisfactory cosmetic and functional result.
  
  
  CONCLUSIONS
  Diffuse, high-grade, anal intraepithelial neoplasia is rare. Excision of these lesions remains controversial but may be the best option.
authors.affiliation: Department of Surgery, Groote Schuur Hospital and the University of Cape Town, South Africa.
authors.forename: D J
authors.initials: DJ
authors.lastname: Browse
authors.forename: R J
authors.initials: RJ
authors.lastname: Baigrie
authors.forename: P A
authors.initials: PA
authors.lastname: Goldberg
authors.forename: J
authors.initials: J
authors.lastname: Nevin
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000502:physiology; D001005:Anus Neoplasms / Q000473:pathology / Q000601:surgery*; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D019651:Plastic Surgery Procedures; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods*; D013524:Surgical Flaps; D014846:Vulvar Neoplasms