title: CRM646-A and -B, novel fungal metabolites that inhibit heparinase.
authors.forename: H R
authors.initials: HR
authors.lastname: Ko
authors.forename: B Y
authors.initials: BY
authors.lastname: Kim
authors.forename: W K
authors.initials: WK
authors.lastname: Oh
authors.forename: D O
authors.initials: DO
authors.lastname: Kang
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.forename: H
authors.initials: H
authors.lastname: Koshino
authors.forename: H
authors.initials: H
authors.lastname: Osada
authors.forename: T I
authors.initials: TI
authors.lastname: Mheen
authors.forename: J S
authors.initials: JS
authors.lastname: Ahn
mesh_terms: D000164:Acremonium / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D006493:Heparin / Q000378:metabolism; D019763:Heparin Lyase / Q000037:antagonists & inhibitors*; D062385:Hydroxybenzoates / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D015394:Molecular Structure; D009361:Neoplasm Invasiveness; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; C408433:CRM646 A; C408434:CRM646 B; D004791:Enzyme Inhibitors; D062385:Hydroxybenzoates; D006493:Heparin; D019763:Heparin Lyase