The role of iron in Parkinson disease and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.
Parkinson disease (PD) involves the specific degeneration of dopaminergic neurons of the pars compacta of the substantia nigra. Although the cause of the degeneration of nigrostriatal dopaminergic neurons in PD is unknown, there is significant evidence to suggest that oxidative stress may be involved in this process. This review specifically examines the current status of evidence suggesting iron may contribute to oxidative damage associated with PD.
Yantiri
F
F
Ethel Percy Andrus Gerontology Center, University of Southern California, Los Angeles 90089-0191, USA.
Andersen
J K
JK
D000818:Animals; D015259:Dopamine Agents / Q000633:toxicity; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000378:metabolism*; D020267:MPTP Poisoning / Q000209:etiology / Q000378:metabolism; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism*; D013378:Substantia Nigra / Q000378:metabolism
D015259:Dopamine Agents; D005293:Ferritins; D007501:Iron