title: Epidermolytic ichthyosis in a dog: clinical, histopathological, immunohistochemical and ultrastructural findings.
abstract: Epidermolytic hyperkeratosis (EH) in man is a complex of congenital, ichthyosiform skin diseases characterized clinically by blistering and hyperkeratosis. These clinical signs are the result of a collapse of the cytoskeleton, seen ultrastructurally as tonofilament clumping and cytolysis within terminally differentiating epidermal cells. In man, specific mutations in keratin 1, 2e, 9 or 10 underlie the various types of EH. This report describes the clinical, histopathological, immunohistochemical and ultrastructural findings in a 6-month-old dog with severe multifocal hyperkeratosis. The morphological changes were comparable with those of EH in man, indicating that this disease, presumably with a similar underlying pathogenetic mechanism, also occurs in the dog.
authors.affiliation: Department of Pathology, School of Veterinary Medicine Hannover, D-30559 Hannover, Bünteweg 17, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Mecklenburg
authors.forename: U
authors.initials: U
authors.lastname: Hetzel
authors.forename: S
authors.initials: S
authors.lastname: Ueberschär
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004817:Epidermis / Q000473:pathology; D005260:Female; D007057:Ichthyosis / Q000473:pathology / Q000662:veterinary*; D015603:Keratinocytes / Q000473:pathology; D008854:Microscopy, Electron / Q000662:veterinary