title: Theoretical aspects of the neurobiological integration of memory.
abstract: Whenever a peripheral structure like the visual system captures information, the input signal reverberates in circuits of neurons, which send it thereafter towards: (a) the motor system, triggering a specific response, evoked by a short-term memory mechanism; and (b) the hippocampus, to produce long-term potentiation or depression. Two different processes regulate short-term memory: (1) Homosynaptic depression that inhibits neurotransmitter release by means of a decrease in Ca++ inflow, and an increase in calmodulin affinity for synaptic vesicles; and (2) Heterosynaptic facilitation that triggers neurotransmitter release, whenever serotonin activates a proteinkinase A. Besides carrying out a brief review on the matter, we support two different physiological explanations with regard to: (a) ion exchange process and the interstitial pH during habituation; and (b) the possibility of a sensitive presynaptic neuron interaction within the habituated reverberant circuit, to trigger dishabituation. We also propose the term 'time-mediated stimulatory action dependent' to name those serotonin receptors that may lead to a rapid or a delayed postsynaptic onset responses.
authors.affiliation: Division of Research and Teaching, Hospital of Cardiology at the Siglo XXI National Medical Center, IMSS, México, DF.
authors.forename: A
authors.initials: A
authors.lastname: Mansilla
authors.forename: H
authors.initials: H
authors.lastname: Barajas
authors.forename: R
authors.initials: R
authors.lastname: Argüero
mesh_terms: D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D008568:Memory / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
chemical_list: D017868:Cyclic AMP-Dependent Protein Kinases