title: New strategies for the synthesis of biologically important tetrapyrroles. The "B,C + D + A" approach to linear tetrapyrroles.
abstract: Linear tetrapyrroles related to phytochrome (1) were prepared in enantiospecific fashion by a new strategy beginning with ring-B,C synthons of type 19 (bis-iododipyrrins). Rings A and D were elaborated by Pd(0)-mediated coupling of 19a with the appropriate alkyne acid or amide derivatives 9 and 20, followed by intramolecular cyclization (method C: BC + D + A --> ABCD).
authors.affiliation: Hall-Atwater Laboratories, Wesleyan University, Middletown, Connecticut 06459-0180, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Jacobi
authors.forename: L D
authors.initials: LD
authors.lastname: Coutts
authors.forename: J
authors.initials: J
authors.lastname: Guo
authors.forename: S I
authors.initials: SI
authors.lastname: Hauck
authors.forename: S H
authors.initials: SH
authors.lastname: Leung
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D045725:Tetrapyrroles
chemical_list: D011758:Pyrroles; D045725:Tetrapyrroles