[Serotonin metabolism in the rat brain during water deprivation and hydration].
Water deprivation (WD) decreased the serotonin (5-HT) level and significantly increased the 5-hydroxyindoleacetic acid (5-HIAA) in the rat midbrain and hypothalamus, the catabolic 5-HIAA/5-HT ratio increasing three-fold. Hydration (H) produced a moderate increase in the 5-HT and 5-HIAA levels in the hypothalamus with no changes in the 5-HIAA/5-HT ratio. Hydration exerted no significant effect upon the 5-HT level and metabolism in the midbrain. A two-fold increase of corticosterone concentration in water deprivation and its decrease in hydration were shown to occur in peripheral blood plasma.
Popova
N K
NK
Institute of Cytology and Genetics, Siberian Branch of the Russian Acad. Sci., Novosibirsk.
Ivanova
L N
LN
Amstislavskaia
T G
TG
Melidi
N N
NN
Naumenko
K S
KS
Maslova
L N
LN
Bulygina
V V
VV
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004326:Drinking; D004327:Drinking Behavior; D006706:Homeostasis; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007038:Hypotonic Solutions; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013395:Sucrose / Q000008:administration & dosage; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
D007038:Hypotonic Solutions; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D013395:Sucrose