Toxic epidermal necrolysis associated with quinidine administration.
Toxic epidermal necrolysis (TEN) is a rare, life threatening, drug induced cutaneous reaction first reported by Lyell in 1956. He named the condition TEN to distinguish it from staphylococcal scalded skin syndrome. It is characterized by a separation of the epidermis and dermis with subsequent desquamation of skin. The denuded areas of skin have the appearance of second-degree burn. Drug induced TEN is a disease of severe morbidity and high mortality. The drugs most frequently associated with onset of the condition are sulfonamides, anticonvulsants, non-steroidal anti-inflammatory drugs, and allopurinol. This study reports the occurrence of TEN in a patient receiving Quinidine.
Adornato
M C
MC
Department of Oral & Maxillofacial Surgery, Nassau County Medical Center, USA.
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology; D011802:Quinidine / Q000009:adverse effects*; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000209:etiology*
D000889:Anti-Arrhythmia Agents; D011802:Quinidine