title: Solid-phase synthesis of carbocyclic nucleosides.
abstract: [formula: see text] An efficient solid-phase synthesis of carbocyclic nucleosides has been developed. The key step is the palladium-catalyzed coupling of a purine derivative to a resin-bound allylic benzoate. The resulting products may be further functionalized on the solid phase. Acidic cleavage affords carbocyclic nucleosides, a class of compounds with demonstrated biological activity and substantial current interest.
authors.affiliation: Venable and Kenan Laboratories of Chemistry, University of North Carolina, Chapel Hill 27599-3290, USA. crimmins@email.unc.edu
authors.forename: M T
authors.initials: MT
authors.lastname: Crimmins
authors.forename: W J
authors.initials: WJ
authors.lastname: Zuercher
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
chemical_list: D009705:Nucleosides; D010165:Palladium