Efficient palladium-catalyzed N-arylation of indoles.
[equation--see text] The N-arylation of indoles, including a variety of substituted ones, has been carried out using bulky, electron-rich phosphines as the supporting ligand in combination with Pd(2)(dba)(3). Using this catalyst system, the efficient coupling of indole and a variety of substituted indoles with aryl iodides, bromides, chlorides, and triflates can be achieved.
Old
D W
DW
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Harris
M C
MC
Buchwald
S L
SL
D001965:Bromides; D002384:Catalysis; D002712:Chlorides; D015195:Drug Design; D007211:Indoles / Q000737:chemistry*; D007454:Iodides; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium; D013329:Structure-Activity Relationship
D001965:Bromides; D002712:Chlorides; D007211:Indoles; D007454:Iodides; D010165:Palladium