title: Primary malignant melanoma of the anterior mediastinum in a child.
abstract: Primary malignant melanoma of the mediastinum is extremely rare. We report a case not previously reported of primary malignant melanoma located in the mediastinum in a 11-year-old boy. The tumor could not be completely resected as a result of extensive invasion of the large blood vessels. Histologically, the tumor was heavily pigmented and composed of vague fascicles of spindle cells intermingled with epithelioid cells. Immunohistochemical analysis showed vimentin, S-100 protein, Melan-A, and HMB-45 immunoreactivity in most of the tumor cells. Nearly 50% of the tumor cells were also positive for p53. It is suggested that primary malignant melanoma of the anterior mediastinum may have a histogenetic relationship to the recently described aggregates of nevus cells in the thymus or mediastinal lymph nodes.
authors.affiliation: Department of Pathology, Rambam Medical Center, Haifa, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Vlodavsky
authors.forename: O
authors.initials: O
authors.lastname: Ben-Izhak
authors.forename: L A
authors.initials: LA
authors.lastname: Best
authors.forename: H
authors.initials: H
authors.lastname: Kerner
mesh_terms: D002648:Child; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed