title: The synthesis of chiral cyanohydrins by oxynitrilases.
abstract: Enantiomerically pure cyanohydrins are important synthetic intermediates for pharmaceuticals and agrochemicals. They are produced by enzyme-catalysed synthesis using oxynitrilases. Sufficient quantities of enzyme are available via cheap natural sources and there have been recent advances in overexpression production of cyanohydrins on an industrial scale.
authors.affiliation: Institute of Organic Chemistry, Technical University Graz, SFB Biocatalysis of the Austrian Science Fund, Stremayrgasse 16, A-8010 Graz, Austria. griengl@orgc.tu-graz.ac.at
authors.forename: H
authors.initials: H
authors.lastname: Griengl
authors.forename: H
authors.initials: H
authors.lastname: Schwab
authors.forename: M
authors.initials: M
authors.lastname: Fechter
mesh_terms: D000446:Aldehyde-Lyases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D001671:Biochemistry / Q000379:methods*; D003001:Cloning, Molecular; D009570:Nitriles / Q000138:chemical synthesis* / Q000378:metabolism; D010944:Plants / Q000201:enzymology; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D009570:Nitriles; D011994:Recombinant Proteins; D000446:Aldehyde-Lyases; C021541:mandelonitrile lyase