[Neurological complications after organ transplantation].
Following organ transplantation, 30-60% of patients develop neurologic complications which can be classified as pre-existing deficits due to the underlying disease, complications during surgery, metabolic encephalopathies, neurotoxicity of immunosuppressant agents, opportunistic CNS infections, and secondary malignomas as indirect side effects of immunosuppression. While encephalopathies, seizures, or CNS infection can occur in all types of transplantation, some specific neurological complications exist for different types of organ transplantation. In this review, the clinical symptoms and treatment of both the common neurological complications as well as the particular neurological syndromes after liver, heart, and bone marrow transplantation are discussed.
Padovan
C S
CS
Neurologische Klinik, Klinikum Grosshadern, Ludwig-Maximilians-Universität München. padovan@brain.nefo.med.uni-muenchen.de
Sostak
P
P
Straube
A
A
D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology / Q000821:virology; D002494:Central Nervous System Infections / Q000209:etiology / Q000382:microbiology / Q000821:virology; D003937:Diagnosis, Differential; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016031:Liver Transplantation / Q000009:adverse effects; D016377:Organ Transplantation / Q000009:adverse effects*
D007166:Immunosuppressive Agents