Synthesis and pharmacology of seleninic acid analogues of the inhibitory neurotransmitter gamma-aminobutyric acid.
[structure: see text] The first seleninic acid analogues of gamma-aminobutyric acid (GABA) and of the specific GABA(A) agonist piperidine-4-carboxylic acid (isonipecotic acid), 1 and 2, respectively, have been synthesized and shown to be potent agonists at the GABA receptors.
Stuhr-Hansen
N
N
Department of Chemistry, University of Copenhagen, Denmark.
Ebert
B
B
Krogsgaard-Larsen
P
P
Kehler
J
J
D000818:Animals; D018755:GABA Agonists / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism; D018080:Receptors, GABA-B / Q000378:metabolism; D018036:Selenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives*
D018755:GABA Agonists; D018377:Neurotransmitter Agents; D010880:Piperidines; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D018036:Selenium Compounds; D005680:gamma-Aminobutyric Acid