Differential expression of cytoskeletal proteins in the dendrites of parvalbumin-positive interneurons versus granule cells in the adult rat dentate gyrus.
Parvalbumin-positive interneurons and granule cells of the dentate gyrus exhibit characteristic differences in morphological, cytochemical, physiological, and pathophysiological properties. Several of these defining features, including dendritic morphology, spine density, and sensitivity to insults, are likely to be influenced by the neuronal cytoskeleton. The data in this paper demonstrate striking differences in the expression levels of all three neurofilament triplet proteins, as well as alpha-internexin and beta-tubulin III, between the parvalbumin-positive interneurons and dentate granule cells. Therefore, the molecular composition of intermediate filaments and microtubules in the dendritic domain of parvalbumin-positive dentate interneurons is distinct from the cytoskeleton of neighboring granule cells, indicating the existence of highly cell type-specific cytoskeletal architecture within the dentate gyrus.
de Haas Ratzliff
A
A
Department of Anatomy and Neurobiology, University of California, Irvine 92697-1280, USA.
Soltesz
I
I
D000367:Age Factors; D000818:Animals; D002352:Carrier Proteins / Q000032:analysis; D003599:Cytoskeleton / Q000737:chemistry*; D003712:Dendrites / Q000737:chemistry*; D018891:Dentate Gyrus / Q000166:cytology*; D005455:Fluorescent Antibody Technique; D007381:Intermediate Filament Proteins / Q000032:analysis; D007395:Interneurons / Q000737:chemistry* / Q000648:ultrastructure; D008297:Male; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins / Q000032:analysis; D016900:Neurofilament Proteins / Q000032:analysis; D010320:Parvalbumins / Q000032:analysis*; D064531:Peripherins; D051381:Rats; D017208:Rats, Wistar; D014404:Tubulin / Q000032:analysis; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D002352:Carrier Proteins; D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D010320:Parvalbumins; D064531:Peripherins; D014404:Tubulin; C046643:alpha-internexin; C044882:neurofilament protein L; C051774:neurofilament protein H; C061195:neurofilament protein M; D005680:gamma-Aminobutyric Acid