title: Synthesis of multiply substituted, ion channel forming octi(p-phenylene)s: theme and variations.
abstract: [reaction: see text] To facilitate the access to unique models for biological processes, we examined six different synthetic routes to octi(p-phenylene) rods with lateral and terminal substituents R(L) and R(T). This systematic study allowed us to increase to overall yield for the synthesis of a new class of oligo(p-phenylene) ionophores about 20 times and to provide general insights into the practicability of synthetic routes to multiply substituted molecular rods.
authors.affiliation: Department of Organic Chemistry, University of Geneva, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Robert
authors.forename: J Y
authors.initials: JY
authors.lastname: Winum
authors.forename: N
authors.initials: N
authors.lastname: Sakai
authors.forename: D
authors.initials: D
authors.lastname: Gerard
authors.forename: S
authors.initials: S
authors.lastname: Matile
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000627:therapeutic use; D007473:Ion Channels / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D004988:Ethers, Cyclic; D007473:Ion Channels