title: Prions: Portable prion domains.
abstract: Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
authors.affiliation: Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, 20892-0830, USA. wickner@helix.nih.gov
authors.forename: R B
authors.initials: RB
authors.lastname: Wickner
authors.forename: K L
authors.initials: KL
authors.lastname: Taylor
authors.forename: H K
authors.initials: HK
authors.lastname: Edskes
authors.forename: M L
authors.initials: ML
authors.lastname: Maddelein
mesh_terms: D000818:Animals; D001665:Binding Sites; D005656:Fungal Proteins / Q000378:metabolism*; D005979:Glutathione Peroxidase; D010454:Peptide Termination Factors; D011328:Prions / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D005656:Fungal Proteins; D010454:Peptide Termination Factors; D011328:Prions; C068068:SUP35 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D005979:Glutathione Peroxidase; C067020:URE2 protein, S cerevisiae