Detection of coronary artery disease and the role of traditional risk factors in the Hopkins Lupus Cohort.
Coronary artery disease (CAD) is a major cause of morbidity and mortality in SLE, including the Hopkins Lupus Cohort. Currently, 9% of the cohort have had clinical evidence (angina or myocardial infarction) of CAD. In our initial prospective study we found that duration of prednisone, hypertension, hyperlipidemia and obesity were risk factors for later CAD. We can now extend that list to include age, male sex, elevated homocysteine, renal insufficiency and antiphospholipid antibodies. Many of the risk factors are amenable to intervention, but the timing of intervention, and the effectiveness of intervention, must be determined.
Petri
M
M
Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. mpetri@welchlink.welch.jhu.edu
D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D015331:Cohort Studies; D003327:Coronary Disease / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008954:Models, Biological; D011241:Prednisone / Q000009:adverse effects; D011446:Prospective Studies; D012307:Risk Factors
D000893:Anti-Inflammatory Agents; D000960:Hypolipidemic Agents; D006886:Hydroxychloroquine; D011241:Prednisone