Functionalized porous silica microspheres as scavengers in parallel synthesis.
The use of solid scavengers in parallel solution-phase organic synthesis is an effective method for work-up and purification. Functionalized macroreticular or gel-form polystyrene particles are generally used for scavenging applications, how ever these materials have some limitations. We have developed new scavenging reagents based on ultrapure silica microspheres displaying a variety of functional groups useful for sequestering impurities from reaction products. These materials are easy to handle, have excellent mass-transfer properties, and are efficient scavengers in both polar and nonpolar organic solvents. The properties of these materials were tailored specifically to fit the needs of a medicinal chemist employing parallel synthesis techniques in current commercial equipment. Results are presented from head-to-head comparisons with conventional scavengers in tests designed to demonstrate the versatility of these new materials.
Thompsona
L A
LA
DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA. drew.a.thompson@dupontpharma.com
Combsa
A P
AP
Trainor
G L
GL
Wangb
Q
Q
Langloisb
T J
TJ
Kirkland
J J
JJ
D000577:Amides / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008863:Microspheres; D015394:Molecular Structure; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents
D000577:Amides; D012997:Solvents; D012822:Silicon Dioxide