title: Linkage analysis of chromosome 2q in osteoarthritis.
abstract: BACKGROUND
  In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA).
  
  
  OBJECTIVE
  To test chromosome 2q for linkage to idiopathic osteoarthritis.
  
  
  METHODS
  Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM.
  
  
  RESULTS
  Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132).
  
  
  CONCLUSIONS
  Chromosome 2q is likely to contain at least one susceptibility locus for OA.
authors.affiliation: University of Oxford, Institute of Molecular Medicine, Oxford, UK.
authors.forename: J
authors.initials: J
authors.lastname: Loughlin
authors.forename: Z
authors.initials: Z
authors.lastname: Mustafa
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Irven
authors.forename: A J
authors.initials: AJ
authors.lastname: Carr
authors.forename: K
authors.initials: K
authors.lastname: Clipsham
authors.forename: J
authors.initials: J
authors.lastname: Chitnavis
authors.forename: V A
authors.initials: VA
authors.lastname: Bloomfield
authors.forename: M
authors.initials: M
authors.lastname: McCartney
authors.forename: O
authors.initials: O
authors.lastname: Cox
authors.forename: J S
authors.initials: JS
authors.lastname: Sinsheimer
authors.forename: B
authors.initials: B
authors.lastname: Sykes
authors.forename: K E
authors.initials: KE
authors.lastname: Chapman
mesh_terms: D000328:Adult; D000368:Aged; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics*; D010375:Pedigree; D012720:Severity of Illness Index