Attraction or repulsion by local Ca(2+) signals.
Recent studies have shown that cytosolic Ca(2+) signals, generated on one side of a nerve growth cone, can induce turning either towards or away from the side of the Ca(2+) signal, depending on the global Ca(2+) level. The results indicate that local Ca(2+) signals may provide important directional cues for axon guidance.
Petersen
O H
OH
MRC Secretory Control Research Group, Department of Physiology, University of Liverpool, UK. o.h.petersen@liverpool.ac.uk
Cancela
J M
JM
D000818:Animals; D001369:Axons / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D002766:Cholecystokinin / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D020439:Growth Cones / Q000502:physiology*; D006801:Humans
D002766:Cholecystokinin; D002118:Calcium