[Tolerance of acellular pertussis vaccine booster injection in 15-20-month-old children].
Severe reactions to whole cell pertussis vaccine are the main reason for the poor adhesion of parents and practitioners to pertussis vaccine booster injections in children, leading to a poor immunization in the population, particularly in young adults. The acellular pertussis vaccine appears to be better tolerated while keeping a good immunogenicity. In a randomized multicentric study on pertussis vaccine booster injection tolerance in 386 15-20 month-old children, we confirmed the better local and general tolerance of the acellular vaccine as compared with the whole cell vaccine. This should help to develop a positive opinion toward pertussis vaccine among parents and practitioners, and to improve the level of active pertussis immunization among children, adolescents, and young adults.
Mallet
E
E
Département de pédiatrie, Hôpital Charles-Nicolle, Rouen, France.
Puyt
A
A
Arson
S
S
Surbled
V
V
D005260:Female; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D014917:Whooping Cough / Q000517:prevention & control
D010567:Pertussis Vaccine