title: Molecular mechanism of monoamine toxicity in Parkinson's disease: hypothetical cell death model.
abstract: Although there have been experimental approaches to understanding the etiology of Parkinson's disease, the cause of cell degeneration in this neurological disorder remains a mystery. Herein, a hypothetical model is proposed to explain the mechanism leading neurons to die. The model is based on recent experimental evidence and it attempts to dissect the actions of dopamine and metal ions as potential triggers for the activation of an ordered cascade of events of the cell death machinery.
authors.affiliation: School of Medicine, University of Antioquia, Medellin, Colombia.
authors.forename: M
authors.initials: M
authors.lastname: Jimenez del Rio
authors.forename: C
authors.initials: C
authors.lastname: Velez-Pardo
mesh_terms: D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology / Q000633:toxicity*; D016923:Cell Death; D004298:Dopamine / Q000502:physiology; D006801:Humans; D008670:Metals; D008959:Models, Neurological; D009474:Neurons / Q000473:pathology*; D010300:Parkinson Disease / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D015306:Biogenic Monoamines; D008670:Metals; D004298:Dopamine