title: Amnioinfusion for preterm rupture of membranes.
abstract: BACKGROUND
  Preterm rupture of membranes places a fetus at risk of cord compression and amnionitis. Amnioinfusion aims to prevent or relieve umbilical cord compression by infusing a solution into the uterine cavity.
  
  
  OBJECTIVE
  The objective of this review was to assess the effects of amnioinfusion for preterm rupture of membranes on maternal and perinatal outcomes.
  
  
  METHODS
  The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were searched.
  
  
  METHODS
  Randomised trials of amnioinfusion compared to no amnioinfusion in women with preterm rupture of membranes.
  
  
  METHODS
  Eligibility and trial quality were assessed by the reviewer.
  
  
  RESULTS
  One trial of 66 women was included. It had some methodological flaws. No significant differences between amnioinfusion and no amnioinfusion were detected for caesarean section (relative risk 0.32, 95% confidence interval 0.07 to 1.40); low Apgar scores (relative risk 0.28, 95% confidence interval 0.03 to 2.33) or neonatal death (relative risk 0.55, 95% confidence interval 0.05 to 5.77). In the amnioinfusion group, the number of severe fetal heart rate decelerations per hour during the first stage of labour were reduced (weighted mean difference -1.20, 95% confidence interval -1.83 to -0.57). These outcomes are consistent with those found in the Cochrane review on amnioinfusion for cord compression.
  
  
  CONCLUSIONS
  There is not enough evidence concerning the use of amnioinfusion for preterm rupture of membranes.
authors.affiliation: Department of Obstetrics and Gynaecology, Coronation Hospital and University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa. 091just@chiron.wits.ac.za
authors.forename: G J
authors.initials: GJ
authors.lastname: Hofmeyr
mesh_terms: D000650:Amnion; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000628:therapy*; D006801:Humans; D007267:Injections; D007552:Isotonic Solutions; D011247:Pregnancy; D000077325:Ringer's Lactate; D012965:Sodium Chloride
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; D012965:Sodium Chloride