title: Does the mitochondrial transcription-termination complex play an essential role in controlling differential transcription of the mitochondrial DNA?
abstract: The mechanism of mitochondrial transcription is well documented although the method of regulation remains obscure. The mitochondrial transcription-termination complex, mTERF, holds a key position in determining the fate of heavy-strand promotor-initiated transcripts and has been suggested as a candidate in the regulation of mitochondrial DNA (mtDNA) transcription. We report here the first example of a modulation of mTERF-complex binding activity concomitant with a differential mtDNA transcription rate. We suggest that these observations are indicative of a method of intra-organellar transcriptional fine tuning.
authors.affiliation: Department of Neurology, University of Newcastle upon Tyne, The Medical School, UK.
authors.forename: S P
authors.initials: SP
authors.lastname: Selwood
authors.forename: Z M
authors.initials: ZM
authors.lastname: Chrzanowska-Lightowlers
authors.forename: R N
authors.initials: RN
authors.lastname: Lightowlers
mesh_terms: D003600:Cytosol / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism*; D008957:Models, Genetic; D011485:Protein Binding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012343:RNA, Transfer / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D004272:DNA, Mitochondrial; D012333:RNA, Messenger; D012343:RNA, Transfer