title: Long-term consumption of red wine does not modify intestinal absorption or status of zinc and copper in rats.
abstract: Red wines contain many components such as polyphenols and ethanol that may influence mineral absorption. We report on studies in a rat model that were designed to investigate the extent to which short- and long-term intake of red wine or ethanol may influence (67)Zn and (65)Cu absorption in rats. Rats (n = 96) were divided into three groups, a control group that received demineralized water, a group that received red wine diluted with water (v/v) and an ethanol group that received 6% ethanol. Half of each group was used for the short-term study; the others were used for the long-term study. After 3 d (short-term study) or 28 d (long-term study) of beverage consumption, the rats were gavaged with 2 mL of solution containing 2027 nmol (67)Zn and 902 nmol (65)Cu. Subsequently, 3-d urinary and fecal collections were performed and analyzed for total and isotopic Zn and Cu. In the long-term study, blood, tibia and liver were also sampled for mineral status assessment. Neither short- nor long-term intake of red wine altered (67)Zn or (65)Cu absorption. In contrast, long-term (but not short-term) ethanol consumption significantly increased both (67)Zn and (65)Cu absorption compared with the control and red wine groups. The long-term consumption of ethanol or red wine did not affect blood or tissue Zn or Cu levels. In conclusion, short- or long-term consumption of red wine did not have a negative effect on intestinal absorption or tissue levels of zinc and Cu in rats.
authors.affiliation: Centre de Recherche en Nutrition Humaine d'Auvergne, Laboratoire Maladies Métaboliques et Micronutriments, INRA de Clermont-Ferrand/Theix, 63122 Saint Genès Champanelle, France.
authors.forename: C
authors.initials: C
authors.lastname: Coudray
authors.forename: J C
authors.initials: JC
authors.lastname: Tressol
authors.forename: C
authors.initials: C
authors.lastname: Feillet-Coudray
authors.forename: J
authors.initials: J
authors.lastname: Bellanger
authors.forename: D
authors.initials: D
authors.lastname: Pépin
authors.forename: A
authors.initials: A
authors.lastname: Mazur
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D004032:Diet; D000431:Ethanol / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014920:Wine; D015032:Zinc / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000431:Ethanol; D003300:Copper; D015032:Zinc