title: The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans.
abstract: Peroxisome proliferator-activated receptors (PPAR) are transcription factors that regulate adipocyte differentiation and gene expression. We tested the hypothesis that the Pro12Ala variant of PPAR-gamma2 is associated with obesity and type 2 diabetes-related traits in 921 subjects from the San Antonio Family Heart Study. Subjects with at least one Ala allele (n=210) had significantly higher body mass index (P=0.015) and waist circumference (P=0.028) and significantly higher levels of serum leptin (P= 0.022) than those without the allele. Further studies will determine whether the Pro12Ala variant itself, or other genetic variation at PPAR-gamma, is responsible for this association with measures of obesity in Mexican Americans.
authors.affiliation: Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA. scole@darwin.sfbr.org
authors.forename: S A
authors.initials: SA
authors.lastname: Cole
authors.forename: B D
authors.initials: BD
authors.lastname: Mitchell
authors.forename: W C
authors.initials: WC
authors.lastname: Hsueh
authors.forename: P
authors.initials: P
authors.lastname: Pineda
authors.forename: B A
authors.initials: BA
authors.lastname: Beamer
authors.forename: A R
authors.initials: AR
authors.lastname: Shuldiner
authors.forename: A G
authors.initials: AG
authors.lastname: Comuzzie
authors.forename: J
authors.initials: J
authors.lastname: Blangero
authors.forename: J E
authors.initials: JE
authors.lastname: Hixson
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics; D008297:Male; D017058:Mexican Americans / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics*; D013781:Texas; D014157:Transcription Factors / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D020738:Leptin; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors