title: A new cucurbitacin glycoside from Kageneckia oblonga (Rosaceae).
abstract: A novel cucurbitacin glycoside has been isolated from aerial parts of Kageneckia oblonga R. et P. and shown to be 3beta-(beta-D-glucosyloxy)-16alpha,23alpha-epoxycuc urbita-5,24-dien-11-one. The structure was established by usual spectroscopic and two-dimensional (2D) NMR techniques. This compound has found to be nontoxic when tested in-vivo cell culture assays. In previous investigations we reported 23,24-dihydrocucurbitacin F and prunasine. This was the first report on cucurbitacins from the genus Kageneckia (Rosaceae).
authors.affiliation: Departamento de Química, Facultad de Ciencias, Universidad de Chile, Santiago. omunoz@abello.dic.uchile.cl
authors.forename: O
authors.initials: O
authors.lastname: Muñoz
authors.forename: C
authors.initials: C
authors.lastname: Delporte
authors.forename: N
authors.initials: N
authors.lastname: Backhouse
authors.forename: S
authors.initials: S
authors.lastname: Erazo
authors.forename: R
authors.initials: R
authors.lastname: Negrete
authors.forename: S
authors.initials: S
authors.lastname: Maldonado
authors.forename: J L
authors.initials: JL
authors.lastname: López-Pérez
authors.forename: A
authors.initials: A
authors.lastname: San Feliciano
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes; D014407:Tumor Cells, Cultured
chemical_list: C412240:3-(glucosyloxy)-16,23-epoxy-cucurbita-5,24-dien-11-one; D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes