Detection of 23 immunogenic pneumococcal proteins using convalescent-phase serum.
A genomic expression library of Streptococcus pneumoniae was screened with a convalescent-phase serum for immunoreactive proteins. Six known and 17 unknown pneumococcal proteins were detected. Five of the known proteins were surface-located virulence factors, and eight of the unknown proteins were putative membrane proteins.
Zysk
G
G
Department of Medical Microbiology and Virology, University of Duesseldorf, Duesseldorf, Germany. zysk@uni-duesseldorf.de
Bongaerts
R J
RJ
ten Thoren
E
E
Bethe
G
G
Hakenbeck
R
R
Heinz
H P
HP
D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D001426:Bacterial Proteins / Q000276:immunology / Q000302:isolation & purification*; D003289:Convalescence; D008565:Membrane Proteins / Q000276:immunology / Q000302:isolation & purification*; D011008:Pneumococcal Infections / Q000276:immunology*; D014774:Virulence
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D008565:Membrane Proteins