title: [Primary varicose veins--changes in the venous wall and elastic behavior].
abstract: The aetiology of varicosis is still unclear. Investigation of changes in normal veins which result in the formation of varicosis led to examination of elastic properties and histomorphological alterations in the region of the extracellular matrix in the vessel wall of the long saphenous vein in normal and varicose veins. The rigidity of varicose veins was higher than that of normal veins; there was no difference between the varicose vein above a competent valve and the "normal" vein below this competent valve. The matrix proteins demonstrated an increase in total fibres, whereas the elastic fibres were reduced and fragmented, explained the rigidity of varices. These results suggest that the role of the venous valves in the development of varicose veins is secondary to changes of the vein wall.
authors.affiliation: Klinik und Poliklinik für Allgemein- und Abdominalchirurgie, Johannes Gutenberg-Universität Mainz. Kirsch@ach.klinik.uni-mainz.de
authors.forename: D
authors.initials: D
authors.lastname: Kirsch
authors.forename: W
authors.initials: W
authors.lastname: Wahl
authors.forename: T
authors.initials: T
authors.lastname: Böttger
authors.forename: T
authors.initials: T
authors.lastname: Junginger
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D004547:Elastic Tissue / Q000473:pathology* / Q000503:physiopathology; D004548:Elasticity; D005109:Extracellular Matrix / Q000473:pathology / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000473:pathology* / Q000503:physiopathology; D012016:Reference Values; D012501:Saphenous Vein / Q000473:pathology / Q000503:physiopathology; D012756:Sheep; D014648:Varicose Veins / Q000473:pathology* / Q000503:physiopathology