Analgesic principle from Abutilon indicum.
Bioactivity guided isolation of Abutilon indicum yielded eugenol [4-allyl-2-methoxyphenol], which was found to possess significant analgesic activity. At doses of 10, 30, and 50 mg/kg body weight, eugenol exhibited 21.30 (p < 0.05), 42.25 (p < 0.01) and 92.96% (p < 0.001) inhibition of acetic acid induced writhing in mice. At a dose of 50 mg/kg body weight, eugenol showed 33.40% (p < 0.05) prolongation of tail flicking time determined by the radiant heat method.
Ahmed
M
M
Department of Pharmacy, University of Dhaka, Bangladesh. deanphrm@du.bangla.net
Amin
S
S
Islam
M
M
Takahashi
M
M
Okuyama
E
E
Hossain
C F
CF
D000085:Acetates; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D002855:Chromatography, Thin Layer; D005054:Eugenol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry; D010147:Pain Measurement / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats
D000085:Acetates; D000700:Analgesics; D009822:Oils, Volatile; C408963:eugenol-4-allyl-2-methoxyphenol; D005054:Eugenol