title: The axis of interleukin 12 and gamma interferon regulates acute vascular xenogeneic rejection.
abstract: Recent advances using transgenic animals or exogenous complement inhibitors have demonstrated prevention of hyperacute rejection of vascularized organs, but not graft loss due to acute vascular rejection. Using various wild-type and cytokine-deficient mice strains, we have examined the mechanisms of acute vascular rejection. C57BL/6 mice deficient in interleukin12 or gamma interferon showed faster acute vascular rejection than did wild-type mice. Furthermore, mice defective in B-cell development showed no acute vascular rejection. These results demonstrate that the axis of interleukin 12 and gamma interferon provides a survival advantage in vascularized xenografts by delaying or preventing acute vascular rejection caused by a B cell-dependent mechanism.
authors.affiliation: The Experimental Transplantation Surgical Laboratory, John P. Robarts Research Institute, 1400 Western Road, London, Ontario Canada, N6G 2V4.
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: M E
authors.initials: ME
authors.lastname: DeVries
authors.forename: S
authors.initials: S
authors.lastname: Deng
authors.forename: M H
authors.initials: MH
authors.lastname: Khandaker
authors.forename: J G
authors.initials: JG
authors.lastname: Pickering
authors.forename: L H
authors.initials: LH
authors.lastname: Chow
authors.forename: B
authors.initials: B
authors.lastname: Garcia
authors.forename: D J
authors.initials: DJ
authors.lastname: Kelvin
authors.forename: R
authors.initials: R
authors.lastname: Zhong
mesh_terms: D000208:Acute Disease; D000818:Animals; D000906:Antibodies / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D001808:Blood Vessels / Q000276:immunology*; D003331:Coronary Vessels / Q000637:transplantation; D006224:Cricetinae; D006084:Graft Rejection / Q000188:drug therapy*; D006085:Graft Survival; D006168:Guinea Pigs; D016027:Heart Transplantation; D007371:Interferon-gamma / Q000627:therapeutic use*; D018664:Interleukin-12 / Q000627:therapeutic use*; D016030:Kidney Transplantation; D008231:Lymphopenia / Q000276:immunology; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D051381:Rats; D011917:Rats, Inbred Lew; D016038:Skin Transplantation; D014183:Transplantation, Heterologous / Q000379:methods*
chemical_list: D000906:Antibodies; D018664:Interleukin-12; D007371:Interferon-gamma