Lymphoid blastic crisis in Philadelphia chromosome-positive chronic granulocytic leukemia following high-grade non-Hodgkin's lymphoma A case report and review of literature.
In this paper we describe a case of a 65-year old man with a lymphoid blastic crisis of a chronic granulocytic leukemia occurring seven years after a palatine tonsillar non-Hodgkin's lymphoma treated with chemotherapy and radiation therapy. Bone marrow cytogenetic study demonstrated the presence of the typical t(9;22)(q34;q11) and the molecular biology study showed the p210 rearrangement (b2a2). The patient died within a few months, unresponsive to any treatment. This is the first case, described in literature, of a secondary chronic granulocytic leukemia onset with a lymphoid blastic crisis. The authors report the case and a literature review.
Mele
L
L
Istituto di Semeiotica Medica, Università Cattolica del Sacro Cuore, largo Francesco Vito 1, 00168 Rome, Italy. liviop@osa.net
Pagano
L
L
Equitani
F
F
Chiusolo
P
P
Rossi
E
E
Zini
G
G
Teofili
L
L
Leone
G
G
D000368:Aged; D001752:Blast Crisis / Q000209:etiology*; D001854:Bone Marrow Cells / Q000473:pathology; D003582:Cytogenetics; D017809:Fatal Outcome; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D016609:Neoplasms, Second Primary; D014066:Palatine Tonsil / Q000473:pathology; D014178:Translocation, Genetic
D016044:Fusion Proteins, bcr-abl