Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.
O'Neill
P M
PM
Departments of Chemistry and of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.
Bishop
L P
LP
Searle
N L
NL
Maggs
J L
JL
Storr
R C
RC
Ward
S A
SA
Park
B K
BK
Mabbs
F
F
D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D037621:Artemisinins; D001557:Benzenesulfonates; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D003510:Cyclohexanes / Q000737:chemistry / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006418:Heme / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009603:Nitroso Compounds; D010084:Oxidation-Reduction; D010963:Plasmodium falciparum / Q000187:drug effects; D013113:Spin Labels; D013343:Styrenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
D000962:Antimalarials; D037621:Artemisinins; D001557:Benzenesulfonates; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003510:Cyclohexanes; D004365:Drugs, Chinese Herbal; D005296:Ferrous Compounds; D005609:Free Radicals; D009603:Nitroso Compounds; D013113:Spin Labels; D013343:Styrenes; D006418:Heme; C090720:arteflene; C048757:3,5-dibromo-4-nitrosobenzenesulfonate