Solid-phase extraction followed by high-performance liquid chromatography-ionspray interface-mass spectrometry for monitoring of herbicides in environmental water.
In this work we developed a sensitive and specific multiresidue method, based on reversed-phase liquid chromatography-mass spectrometry, with an ionspray interface (LC-ISI-MS), for determining 52 of most representative compounds of herbicides in water samples. The procedure used involved passing 0.5 l of surface water, 2 l of ground water and 4 l of drinking water samples, respectively, through a 0.5 g graphitized carbon black (GCB) extraction cartridge. Base-neutral and acid herbicides were differential eluted from GCB cartridge and follow analyzed by HPLC-ISI-MS apparatus. A conventional 4.6-mm-ID reversed-phase LC C18 column, operating with a mobile phase flow-rate of 1 ml/min, was used to chromatograph the analytes. A flow of 100 microl/min of the column effluent was diverted to the ISI source. The study demonstrates the sensitivity of the technique, with detection limit under 10 ng/l in drinking water samples. Performance data for the method such as recovery and precision are also reported.
Curini
R
R
Dipartimento di Chimica, Università La Sapienza di Roma, Rome, Italy. curini@axrma.uniroma.it
Gentili
A
A
Marchese
S
S
Marino
A
A
Perret
D
D
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004784:Environmental Monitoring; D006540:Herbicides / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014874:Water Pollutants, Chemical / Q000032:analysis*
D006540:Herbicides; D014874:Water Pollutants, Chemical