[Pain and corneal pathology].
Since the development of photorefractive keratectomy, ophtalmologists are concerned by the mechanisms of corneal pain in order to prevent and reduce it. Corneal epithelium and anterior stroma are widely innervated by nasociliary fibers form ophtalmologic nerve (V). Receptors react to a chemical, mechanical and thermal stimulation by an acute and precisely located pain. This pain is developed by release of inflammatory mediators and neuro transmitters. Pain is different regarding the pathology and the treatment: photorefractive keratectomy, Acanthamoeba keratitis, Mooren's ulcer. Topical non steroidal antiinflammatory drugs have a specific role in controlling corneal pain.
Burillon
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Clinique Ophtalmologique, Hôpital Edouard Herriot, 69437 Lyon Cedex 03, France.
D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007249:Inflammation; D054018:Lasers, Excimer; D010146:Pain / Q000503:physiopathology*; D018903:Photorefractive Keratectomy