Leukocyte subsets in treatment-resistant major depression.
Patients with treatment-resistant major depression had a significantly higher percentage of helper CD4+ T cells and immature double positive CD4+CD8+ T cells in their blood, and higher CD4+/CD8+ ratio than healthy controls. These results suggest activation of T helper immuno-response and disturbance in thymus function in these patients.
Kubera
M
M
Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków.
Van Bockstaele
D
D
Maes
M
M
D000328:Adult; D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D003865:Major Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D005473:Fluoxetine / Q000627:therapeutic use; D006801:Humans; D016131:Lymphocyte Subsets; D008875:Middle Aged
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine