title: Size reduction of small bowels from adult cadaveric donors to alleviate the scarcity of pediatric size-matched organs: an anatomical and feasibility study.
abstract: BACKGROUND
  Small bowel transplantation in children weighing less than 10 kg is hindered by the lack of size-matched donors. The ability to create reduced size small bowel grafts from adult cadaveric donors suitable for use in young children has been studied.
  
  
  METHODS
  Volumetric assessment of computed tomography scans were used to evaluate abdominal cavity and small bowel volumes in children. Small bowels were retrieved from adult cadaveric donors and reduced in size.
  
  
  RESULTS
  Computed tomography studies of the abdominal cavity showed that the mean volume available for a small bowel graft was 260 ml in children less than 5 kg (n = 5) and 460 ml in children weighing 5-10 kg (n = 5). Fifteen small bowels were successfully reduced to provide an ileal graft of one meter while keeping the whole length of the superior mesenteric artery and vein after their dissection in the proximal part of the mesentery. The mean volume of the grafts created was 270 ml in seven thin patients (body mass index [BMI] <25), 390 ml in five preobese patients (25< BMI<30), and 490 ml in three obese patients (BMI>30). Mesenteric transillumination in thin donors allowed safe dissection and complete hemostasis. No diameter reduction was required. Technical modifications permitted the creation of two grafts, one ileal and the other jejunal from a single donor. Volumetric and surgical data show that implantation of up to two meters of ileum from a thin adult weighing up to 80 kg is feasible in children weighing less than 10 kg.
  
  
  CONCLUSIONS
  Size reduction of adult cadaveric small bowels can provide suitable grafts for children of less than 10 kg and could expand the potential pool of donors for these patients.
authors.affiliation: Department of Liver Transplant Surgery, King's College Hospital, Camberwell, London, United Kingdom.
authors.forename: L
authors.initials: L
authors.lastname: Delrivière
authors.forename: P
authors.initials: P
authors.lastname: Muiesan
authors.forename: M
authors.initials: M
authors.lastname: Marshall
authors.forename: M
authors.initials: M
authors.lastname: Davenport
authors.forename: A
authors.initials: A
authors.lastname: Dhawan
authors.forename: P
authors.initials: P
authors.lastname: Kane
authors.forename: J
authors.initials: J
authors.lastname: Karani
authors.forename: M
authors.initials: M
authors.lastname: Rela
authors.forename: N
authors.initials: N
authors.lastname: Heaton
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D001835:Body Weight; D002102:Cadaver; D002648:Child; D004210:Dissection; D005240:Feasibility Studies; D005260:Female; D015276:Health Care Rationing; D006801:Humans; D007421:Intestine, Small / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000601:surgery* / Q000637:transplantation*; D008297:Male; D008638:Mesenteric Arteries / Q000000981:diagnostic imaging; D008642:Mesenteric Veins / Q000000981:diagnostic imaging; D008875:Middle Aged; D010372:Pediatrics / Q000379:methods*; D020858:Tissue and Organ Harvesting / Q000379:methods*