title: Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization.
abstract: [structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.
authors.affiliation: Department of Chemistry, University of British Columbia, Vancouver, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Cinel
authors.forename: M
authors.initials: M
authors.lastname: Roberge
authors.forename: H
authors.initials: H
authors.lastname: Behrisch
authors.forename: L
authors.initials: L
authors.lastname: van Ofwegen
authors.forename: C B
authors.initials: CB
authors.lastname: Castro
authors.forename: R J
authors.initials: RJ
authors.lastname: Andersen
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008870:Microtubules / Q000737:chemistry*; D008958:Models, Molecular; D013329:Structure-Activity Relationship
chemical_list: D000470:Alkaloids; D000970:Antineoplastic Agents; D004224:Diterpenes; C109551:eleutherobin