title: Synthesis of the C22-C26 tetrahydropyran segment of phorboxazole by a stereoselective prins cyclization
abstract: [formula: see text] Tetrahydropyran rings are found in many complex natural products, and the segment-coupling Prins cyclization is an effective strategy for their synthesis. We report a four-step, stereoselective synthesis of the C20-C27 tetrahydropyran segment of phorboxazole. The key step is a Prins cyclization induced by catalytic BF3.OEt2.
authors.affiliation: Department of Chemistry, University of California, Irvine 92697-2020, USA. srychnov@uci.edu
authors.initials: SD
authors.lastname: Rychnovsky
authors.initials: CR
authors.lastname: Thomas