title: Remote myocardial dysfunction after acute anterior myocardial infarction: impact of left ventricular shape on regional function: a magnetic resonance myocardial tagging study.
abstract: OBJECTIVE
  We sought to evaluate regional morphology and function in patients in their first week after having a reperfused anterior myocardial infarction (MI) using magnetic resonance (MR) myocardial tagging.
  
  
  BACKGROUND
  The mechanism of myocardial dysfunction in the remote, noninfarct-related regions is an unresolved issue to date.
  
  
  METHODS
  Sixteen patients with a first reperfused transmural anterior MI were studied with MR tagging at 5 +/- 2 days after the event, and the results were compared with those of an age-matched control group regions. The left ventricle (LV) was divided into infarct, adjacent and remote regions. Magnetic resonance tagging provided information on the regional ventricular morphology and function.
  
  
  RESULTS
  Morphologically, an increase of the circumferential radius of curvature was found in the remote myocardium, whereas the longitudinal radius of curvature was increased in all regions of the LV. A significant increase in apical sphericity was also found. A significant reduction in strain and function was found not only in the infarct region, but also in the adjacent and remote myocardium. The loss in regional ejection fraction in the remote myocardium (61.4 +/- 11.7% in patients vs. 68.7 +/- 10.0% in control subjects, p < 0.0001) was related to a significant reduction of the longitudinal and circumferential strain, whereas systolic wall thickening was preserved.
  
  
  CONCLUSIONS
  Remote myocardial dysfunction contributes significantly to the loss in global ventricular function. This could be secondary to morphologic changes in the infarct region, leading to an increased systolic longitudinal wall stress without loss of intrinsic contractility in the remote regions.
authors.affiliation: Department of Radiology, University Hospitals, Leuven, Belgium. Jan.Bogaert@uz.kuleuven.ac.be
authors.forename: J
authors.initials: J
authors.lastname: Bogaert
authors.forename: H
authors.initials: H
authors.lastname: Bosmans
authors.forename: A
authors.initials: A
authors.lastname: Maes
authors.forename: P
authors.initials: P
authors.lastname: Suetens
authors.forename: G
authors.initials: G
authors.lastname: Marchal
authors.forename: F E
authors.initials: FE
authors.lastname: Rademakers
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D009203:Myocardial Infarction / Q000175:diagnosis / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D014055:Tomography, Emission-Computed; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology