Metabolism of [(14)C]flusilazole in the goat.
[Phenyl(U)-(14)C] and [triazole(3)-(14)C]flusilazole ([(bis 4-fluorophenyl)]methyl(1H-1,2,4-triazole-1-ylmethyl)silane; I) were extensively metabolized when fed to lactating goats (Capra hircus). The primary metabolites identified in goat tissues and milk were bis(4-fluorophenyl)(methyl)silanol (II) and 1H-1,2,4-triazole (III). Concentrations of total radiolabeled residues in the milk ranged from 0.09 to 0.74 microg/mL. Concentrations of radiolabeled residues found in tissues when the [(14)C] label was in the phenyl or triazole position, respectively, were 13.5 and 3.54 microg/g (liver), 8.74 and 0.75 microg/g (kidney), 0.41 and 0.52 microg/g (leg muscle), and 4.07 and 0.94 microg/g (back fat). Urine contained an additional major metabolite identified as [bis(4-fluorophenyl)](methyl)silylmethanol (IV) and its glucuronic acid conjugate (V). With either labeled form of flusilazole, the majority of the recovered radiolabel was excreted in urine or feces.
Anderson
J J
JJ
Experimental Station, DuPont Agricultural Products, Wilmington, Delaware 19880-0402, USA.
Shalaby
L M
LM
Berg
D S
DS
D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D002250:Carbon Radioisotopes; D003612:Dairying; D005260:Female; D006041:Goats; D007668:Kidney / Q000378:metabolism; D007774:Lactation; D008099:Liver / Q000378:metabolism; D008892:Milk / Q000737:chemistry* / Q000378:metabolism; D018482:Muscle, Skeletal / Q000378:metabolism; D012821:Silanes / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014230:Triazoles / Q000493:pharmacokinetics*
D000935:Antifungal Agents; D002250:Carbon Radioisotopes; D012821:Silanes; D014230:Triazoles; C061365:flusilazole