[Immunomorphological study of diabetic microangiopathy].
Femoral skin biopsies of 300 patients with insulin-dependent and non-insulin-dependent diabetes were studied immunomorphologically and the results were compared to the level of immunoglobulins in the blood serum. It is found that IgG, beta-lipoproteins, complement were registered in the arterioles and capillary walls in diabetic microangiopathy more frequently than in healthy persons. The conclusion is made that in development of diabetic microangiopathy, in both types of diabetes, immune (immunocomplex) mechanisms that damage vascular wall are involved.
Saltykov
B B
BB
I. M. Sechenov Moscow Medical Academy.
Velikov
V K
VK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001706:Biopsy; D003165:Complement System Proteins / Q000276:immunology*; D003925:Diabetic Angiopathies / Q000097:blood / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology*; D007150:Immunohistochemistry; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D012867:Skin / Q000276:immunology / Q000473:pathology
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; D003165:Complement System Proteins