title: [Degradation of phosphatidylnucleosides induced by phospholipases].
abstract: Hydrolysis of phosphatidylnucleosides, 5'-(rac-1-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoryl)-3'-azido- 3'-deoxythymidine and -2',3'-didehydro-3'-deoxythymidine, effected by phospholipases (PL) A2, C, and D was studied to reveal the metabolism of these derivatives. It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides.
authors.affiliation: State Research Institute of Organic Chemistry and Technology, Moscow, Russia.
authors.forename: T I
authors.initials: TI
authors.lastname: Novozhilova
authors.forename: S I
authors.initials: SI
authors.lastname: Malekin
authors.forename: V I
authors.initials: VI
authors.lastname: Kozhukhov
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Krugliak
authors.forename: V K
authors.initials: VK
authors.lastname: Kurochkin
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry; D015224:Dideoxynucleosides / Q000737:chemistry*; D006868:Hydrolysis; D010712:Phosphatidic Acids / Q000737:chemistry*; D010739:Phospholipase D / Q000737:chemistry; D010740:Phospholipases / Q000737:chemistry; D010741:Phospholipases A / Q000737:chemistry; D054467:Phospholipases A2; D013379:Substrate Specificity; D010738:Type C Phospholipases / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D010712:Phosphatidic Acids; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D010738:Type C Phospholipases; D010739:Phospholipase D