title: Effects of preoperative chemotherapy and radiation therapy on human bronchial blood flow.
abstract: OBJECTIVE
  We investigated the relationship between bronchial mucosal blood flow around the area of lung resection and the state of healing of the bronchial stump in patients after chemotherapy with or without radiation therapy.
  
  
  METHODS
  Ninety patients with primary lung cancer were divided into the following 3 groups: group A, 72 patients who had no preoperative therapy; group B, 10 patients who had chemotherapy; and group C, 8 patients who had chemoradiation (60 Gy) therapy. Bronchial mucosal blood flow was measured preoperatively, intraoperatively, and postoperatively (days 8-10) with a laser Doppler flowmeter.
  
  
  RESULTS
  In groups A and B bronchial mucosal blood flow was preserved sufficiently around the surgical site, and the healing of the bronchial stump was satisfactory. On the contrary, preoperative blood flow in group C was 70% of the preoperative value in group A and decreased further intraoperatively. Healing of the bronchial stump was poor, and a bronchopleural fistula occurred in one patient of group C.
  
  
  CONCLUSIONS
  Preoperative chemoradiation therapy may adversely affect bronchial mucosal blood flow and healing of the bronchial stump, although lymphadenectomy and preoperative chemotherapy had little effect. It is recommended that the bronchial stump should be covered with pedicled viable tissue after chemoradiation therapy for prophylaxis against bronchial complications.
authors.affiliation: Division of Pulmonary Surgery, Osaka City Medical Hospital, Osaka, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Tada
authors.forename: A
authors.initials: A
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Tojo
mesh_terms: D000230:Adenocarcinoma / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001783:Blood Flow Velocity / Q000187:drug effects / Q000528:radiation effects; D001980:Bronchi / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D001999:Bronchoscopy; D002294:Carcinoma, Squamous Cell / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008175:Lung Neoplasms / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011013:Pneumonectomy; D011300:Preoperative Care / Q000379:methods; D011878:Radiotherapy; D020545:Respiratory Mucosa / Q000098:blood supply / Q000473:pathology; D012189:Retrospective Studies; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents