Motor coordination without action potentials in the mammalian spinal cord.
Coordination of neuronal activity to produce movement is generally thought to depend on spike activity in premotor interneuronal networks. Here we show that even without such activity, the neonatal rat spinal cord could produce a stable motor rhythm mediated by the synchronization of motor neuron oscillations across gap junctions. These rhythms, however, were not coordinated between motor pools in different parts of the spinal cord. We further showed that neural coordination through gap junctions contributed to the fundamental organization and function of spinal motor systems. These results suggest that neural coordination across gap junctions is important in motor-pattern generation in the mammalian spinal cord.
Tresch
M C
MC
Section of Neurophysiology, Department of Physiology, The Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark.
Kiehn
O
O
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D017629:Gap Junctions / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007395:Interneurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009043:Motor Activity / Q000502:physiology*; D009046:Motor Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009048:Motor Skills / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology; D009415:Nerve Net / Q000502:physiology; D010507:Periodicity; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013268:Stimulation, Chemical; D013779:Tetrodotoxin / Q000494:pharmacology
D012701:Serotonin; D013779:Tetrodotoxin; D016202:N-Methylaspartate; D015763:2-Amino-5-phosphonovalerate; D002118:Calcium