title: Clinical study on Alternaria spores sensitization.
abstract: BACKGROUND
  sensitization to fungi spores is often associated with sensitization to other allergens and so it is difficult to estabilish the exact cause of illness.
  
  
  OBJECTIVE
  the aim of the study was to evaluate a group of patients monosensitized to Alternaria and to establish the prevalence, periodicity and clinical profile of this kind of sensitization.
  
  
  METHODS
  37 subjects who were monosensitized to Alternaria (prick-test positive), according to a previous epidemiological study were evaluated. Clinical symptoms and the period of their occurrence were taken into consideration as well as immunological parameters (RAST).
  
  
  RESULTS
  20 patients (over 50%) included in the study proved to be affected by asthma associated with other allergic symptoms and 22 patients (60%) presented perennial symptoms. The RAST carried out on 34 monosensitized subjects proved positive in 11 and negative in 23.
  
  
  CONCLUSIONS
  Alternaria sensitization is characterized by a perennial periodicity with severe respiratory symptoms (asthma) which occur primarily in children. Prick test is preferable to and more reliable than RAST as a diagnostic test.
authors.affiliation: Servicio de Alergología, Ospedale S. Martino, Génova, Italia.
authors.forename: A C
authors.initials: AC
authors.lastname: Negrini
authors.forename: D
authors.initials: D
authors.lastname: Berra
authors.forename: P
authors.initials: P
authors.lastname: Campi
authors.forename: B
authors.initials: B
authors.lastname: Cinti
authors.forename: R
authors.initials: R
authors.lastname: Corsico
authors.forename: V
authors.initials: V
authors.lastname: Feliziani
authors.forename: M T
authors.initials: MT
authors.lastname: Gallesio
authors.forename: G
authors.initials: G
authors.lastname: Liccardi
authors.forename: A
authors.initials: A
authors.lastname: Loreti
authors.forename: G
authors.initials: G
authors.lastname: Lugo
authors.forename: F
authors.initials: F
authors.lastname: Marcucci
authors.forename: G
authors.initials: G
authors.lastname: Marcer
authors.forename: M
authors.initials: M
authors.lastname: Minelli
authors.forename: G
authors.initials: G
authors.lastname: Nardi
authors.forename: G
authors.initials: G
authors.lastname: Piu
authors.forename: A
authors.initials: A
authors.lastname: Passaleva
authors.forename: M
authors.initials: M
authors.lastname: Pozzan
authors.forename: P
authors.initials: P
authors.lastname: Puccinelli
authors.forename: F
authors.initials: F
authors.lastname: Purello D'Ambrosio
authors.forename: A
authors.initials: A
authors.lastname: Venuti
authors.forename: P
authors.initials: P
authors.lastname: Zanon
mesh_terms: D000293:Adolescent; D000328:Adult; D000528:Alternaria / Q000276:immunology*; D001249:Asthma / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000209:etiology*; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011852:Radioallergosorbent Test; D012621:Seasons; D012882:Skin Tests; D013172:Spores, Fungal / Q000276:immunology