[Radiation-induced acne].
Radiation-induced acne is a rare, clinically and pathogenetically ill-defined acneiform dermatosis with special features that may occur in irradiated skin areas especially after high doses of deeply penetrating radiation. We report on a patient with an oropharyngeal carcinoma who developed severe radiation-induced acne including comedones and cysts as well as few inflammatory papules and pustules in a skin area irradiated with up to 63 gray of a 6 MeV photon beam. Acnegenic drugs may precipitate the disease; our patient was on longterm therapy with carbamazepine whose acnegenic potency is less well documented than that of testosterone or glucocorticoids. Treatment of radiation-induced acne is comedolytic; topical retinoids are especially valuable.
Klemke
C D
CD
Klinik und Poliklinik für Dermatologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin.
Nestoris
S
S
Wölfer
L U
LU
Krengel
S
S
Zouboulis
C C
CC
Tebbe
B
B
Goerdt
S
S
D000152:Acne Vulgaris / Q000139:chemically induced / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D005148:Facial Dermatoses / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D011855:Radiodermatitis / Q000175:diagnosis; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013577:Syndrome
D000927:Anticonvulsants; D002220:Carbamazepine