title: Visceral leishmaniasis in Malta--an 18 year paediatric, population based study.
abstract: BACKGROUND
  Visceral leishmaniasis (VL) is a chronic parasitic infection that infects approximately 400,000 individuals annually, with a predilection towards early childhood.
  
  
  OBJECTIVE
  To study the epidemiology of VL in childhood.
  
  
  METHODS
  VL is endemic in Malta, a small archipelago of islands in the centre of the Mediterranean with a total population approaching half a million. Notification of human cases of leishmaniasis is compulsory. Case records of all 81 paediatric patients with VL between 1980 and 1998 were analysed.
  
  
  RESULTS
  The annual incidence of VL declined for all cases of VL, and declined significantly for paediatric cases (p = 0.01). For 1994 to 1998, the overall incidence of VL was 0.9 per 100,000 total population and the paediatric incidence was 2.5 per 100,000 population. Median age at presentation was 34 months. Common features at presentation were splenomegaly, hepatomegaly, fever, and pancytopenia with high lymphocyte and monocyte counts. The diagnostic sensitivity of isolated immunofluorescent antibody testing was equivalent to bone marrow aspiration (95%). Blood transfusions for anaemia were required in 93% of patients. Eleven per cent had intercurrent infections. All patients were cured, and were initially treated with intravenous sodium stibogluconate. Defervescence occurred after a median of six days of treatment, and patients continued to be treated on a day case basis. Nine relapsers were retreated with sodium stibogluconate, achieving a cure rate of 94%, but five patients required additional drug therapy. There were no permanent sequelae associated with VL or its treatment.
  
  
  CONCLUSIONS
  The decreased incidence is attributed to the eradication of stray dogs which are the disease reservoir.
authors.affiliation: Paediatric Department, St Luke's Hospital Guardamangia, Malta. victor.e.grech@magnet.mt
authors.forename: V
authors.initials: V
authors.lastname: Grech
authors.forename: J
authors.initials: J
authors.lastname: Mizzi
authors.forename: M
authors.initials: M
authors.lastname: Mangion
authors.forename: C
authors.initials: C
authors.lastname: Vella
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D018563:Disease Notification / Q000706:statistics & numerical data; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000592:standards; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008319:Malta / Q000453:epidemiology; D012008:Recurrence; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016896:Treatment Outcome