title: Manometric and hormonal changes after distal partial gastrectomy.
abstract: BACKGROUND
  Alkaline oesophagitis attributable to duodenal mechanisms may induce oesophageal carcinogenesis in a rat reflux model.
  
  
  OBJECTIVE
  To investigate the mechanism of the regurgitation after distal partial gastrectomy.
  
  
  METHODS
  Oesophageal manometry was used in 16 patients before and after distal partial gastrectomy with reconstruction by Bilroth methods. Serum concentrations of four gastrointestinal hormones were measured by radioimmunoassay in 10 gastrectomy patients and nine healthy volunteers before and after a standardized meal.
  
  
  RESULTS
  The lower oesophageal sphincter pressure was reduced to 83% after surgery. The amplitude and duration of the peristaltic waves tended to be increased, and the velocity tended to be less after surgery (amplitude 120%, duration 114%, velocity 88%). Interrupted waves appeared more frequently after surgery. The manometric changes in gastrectomized patients are considered to be disadvantageous relative to regurgitation. After surgery, gastrin and pancreatic polypeptide were completely abolished postprandially, whereas cholecystokinin and neurotensin were significantly increased.
  
  
  CONCLUSIONS
  The hormonal changes should have a suppressive effect on the lower oesophageal sphincter. Both the manometric and the hormonal changes may exacerbate reflux oesophagitis after distal partial gastrectomy.
authors.affiliation: Department of Surgical Oncology, Research Institute for Radiation Biology & Medicine, Hiroshima University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: H
authors.initials: H
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: E
authors.initials: E
authors.lastname: Miyahara
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Toge
authors.forename: T E
authors.initials: TE
authors.lastname: Adrian
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000209:etiology / Q000503:physiopathology; D004942:Esophagitis, Peptic / Q000209:etiology / Q000503:physiopathology*; D004943:Esophagogastric Junction / Q000033:anatomy & histology / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D005764:Gastroesophageal Reflux / Q000503:physiopathology*; D005768:Gastrointestinal Hormones / Q000032:analysis*; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged
chemical_list: D005768:Gastrointestinal Hormones