title: [Autosomal dominant polycystosis in the hospital milieu in Dakar (Senegal)].
abstract: Autosomial dominant polycystic kidney disease (ADPKD) is an hereditary affection transmitted in a autosal dominant pattern with variable penetrancy. Diagnosis is based upon ultrasound examination and/or familial history. The authors present a 8 years retrospective hospital study in order to precise the epidemiological and clinico-biological aspects of ADPKD in Dakar. So 23 patients were studied. The mean age at the diagnosis was 46 years. They were 9 men and 14 women (sex ratio 0.64). A past history of familial nephropathy was found in 52.2% of cases. The circumstances of diagnosis were dominated by lombar pain (52.2%) and hypertension (17.4%) but at examination, blood pressure was high in 34.8% and represent the main factor of worsening the disease. Enlargement of kidney was found in 47.8% and hepatomegaly in 13% of cases. Anemia was particularly common 56.5%. The most frequent extra renal manifestation was the liver cysts and occurs mainly in women. National prevalence of ADPKD and the specific gene should be precise in further studies.
authors.affiliation: Clinique Médicale I du CHU de Dakar, Hôpital Aristide Le Dantec.
authors.forename: B
authors.initials: B
authors.lastname: Diouf
authors.forename: D
authors.initials: D
authors.lastname: Dia
authors.forename: M M
authors.initials: MM
authors.lastname: Ka
authors.forename: E F
authors.initials: EF
authors.lastname: Ka
authors.forename: T M
authors.initials: TM
authors.lastname: Diop
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000740:Anemia / Q000209:etiology; D003430:Cross-Sectional Studies; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006760:Hospitalization / Q000706:statistics & numerical data*; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008297:Male; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology* / Q000235:genetics; D015995:Prevalence; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology; D017678:Sex Distribution