title: Myelointegration of titanium implants: B lymphopoiesis and hemopoietic cell proliferation in mouse bone marrow exposed to titanium implants.
abstract: Multinucleated giant cells have been observed at interfaces between bone marrow and titanium implants in mouse femurs. This raises concern that macrophage-derived factors might perturb local lymphohemopoiesis, possibly even predisposing to neoplasia in the B lymphocyte lineage. It has been found that an implant-marrow interface with associated giant cells persists for at least 1.5 years. Precursor B cells show early increases in number and proliferative activity. At later intervals, however, they do not differ significantly from controls, and there are no perturbations in spatial localization of either B lineage cells or DNA-synthesizing hemopoietic cells. The results of this investigation in mice demonstrate that, following initial marrow regeneration and fluctuating precursor B cell activity, and despite the presence of giant cells, titanium implants apparently become well-tolerated by directly apposed bone marrow cells in a lasting state of "myelointegration."
authors.affiliation: Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
authors.forename: M D
authors.initials: MD
authors.lastname: Rahal
authors.forename: D
authors.initials: D
authors.lastname: Delorme
authors.forename: P I
authors.initials: PI
authors.lastname: Brånemark
authors.forename: D G
authors.initials: DG
authors.lastname: Osmond
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D001672:Biocompatible Materials / Q000737:chemistry; D001854:Bone Marrow Cells / Q000502:physiology*; D001859:Bone Neoplasms / Q000209:etiology; D001861:Bone Regeneration / Q000502:physiology; D002452:Cell Count; D002455:Cell Division; D019070:Cell Lineage; D015921:Dental Implants; D004198:Disease Susceptibility; D005269:Femur / Q000473:pathology; D015726:Giant Cells / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D019891:Leukopoiesis / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D016348:Osseointegration; D013499:Surface Properties; D013997:Time Factors; D014025:Titanium / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D015921:Dental Implants; D014025:Titanium