Effects of prostaglandin E1 administration during hepatectomy for cirrhotic hepatocellular carcinoma.
OBJECTIVE
Prostaglandin E1 has been used in hepatectomy based on a few limited clinical studies suggesting that PGE1 improves liver function. The aim of this study was to evaluate the effects of PGE1 administration during hepatectomy for cirrhotic hepatocellular carcinoma.


METHODS
Forty-three patients undergoing hepatectomy for cirrhotic hepatocellular carcinoma were divided into 2 groups: hepatectomy with Prostaglandin E1 treatment (PG group; n = 19) and without Prostaglandin E1 treatment (control group; n = 24). Prostaglandin E1 (0.02-0.07 microgram/kg/min) was administered intravenously from beginning to end of surgery in the PG group.


RESULTS
There were no significant differences between groups with respect to age, gender, preoperative liver and renal function, or intraoperative variables such as blood loss, weight of resected liver and total clamping time by the Pringle maneuver. No patient had severe postoperative complications. Initial postoperative maximum concentrations of serum total bilirubin, creatinine, and blood urea nitrogen in the PG group were significantly lower than those in the control group.


CONCLUSIONS
Prostaglandin E1 administration during hepatectomy for cirrhotic heptocellular carcinoma resulted in improved renal and hepatic function.
Hanazaki
K
K
Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Kajikawa
S
S
Fujimori
Y
Y
Nakata
S
S
Shimozawa
N
N
Koide
N
N
Adachi
W
W
Amano
J
J
D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007262:Infusions, Intravenous; D007677:Kidney Function Tests; D008103:Liver Cirrhosis / Q000601:surgery*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D012189:Retrospective Studies
D000527:Alprostadil