Tremor-correlated cortical activity detected by electroencephalography.
OBJECTIVE
In this study we investigated whether cortical activity related to Parkinsonian resting tremor can be detected by electroencephalography (EEG).


METHODS
Seven patients with idiopathic Parkinson's disease suffering from unilateral tremor participated in the study. Electromyography (EMG) signals arising from the wrist extensor and flexor muscles as well as a high resolution EEG were recorded simultaneously. Coherencies between EEG and EMG were calculated.


RESULTS
In all patients, we found highly significant coherencies at the tremor frequency or its first harmonic between the tremor EMG and contralateral EEG channels. There were no significant coherencies between the tremor EMG and ipsilateral EEG channels. Isocoherency maps illustrating the topography of the coherencies over the scalp showed that the maximum coherencies were situated over the cortical motor areas. In one case, a high coherency was also found over the parietal cortex.


CONCLUSIONS
The results show for the first time that tremor-correlated cortical activity can be detected by electroencephalography. The findings underline that motor areas of the cerebral cortex are involved in the neuronal network generating resting tremor in Parkinson's disease.
Hellwig
B
B
Neurologische Universitätsklinik, Neurozentrum, Breisacher Strasse 64, 79106, Freiburg, Germany.
Häussler
S
S
Lauk
M
M
Guschlbauer
B
B
Köster
B
B
Kristeva-Feige
R
R
Timmer
J
J
Lücking
C H
CH
D000368:Aged; D001931:Brain Mapping; D004569:Electroencephalography; D004576:Electromyography; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D011712:Pyramidal Tracts / Q000503:physiopathology; D011930:Reaction Time; D014202:Tremor