title: CD studies on the conformation of some deoxyoligonucleotides containing adenine and thymine residues.
abstract: CD studies of the deoxyoligomer series d(pT)(n) and d(pA)(n) show increasing CD maxima for oligo (dT)'s with chain length variation from two to seven, while oligo (dA)'s exhibit a decreasing CD maximum. Concentrated solutions of NaClO(4) cause a decrease in the CD of longer oligo (dT)'s towards the CD of d(pT)(2) which is different from oligo dA's. Probably base-sugar interactions are important in the observed conformational effects. The chemically synthesized oligomers dpApApTpT and dpTpApTpA show deviations in their CD spectra which reflect a dominating conformational effect of d(pA)(2) in the former but not in the alternating isomer.
authors.forename: C
authors.initials: C
authors.lastname: Zimmer
authors.forename: E
authors.initials: E
authors.lastname: Birch-Hirschfeld
authors.forename: R
authors.initials: R
authors.lastname: Weiss
mesh_terms: D000225:Adenine / Q000737:chemistry; D001483:Base Sequence; D002942:Circular Dichroism; D006358:Hot Temperature; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D013941:Thymine / Q000737:chemistry
chemical_list: D009838:Oligodeoxyribonucleotides; D000225:Adenine; D013941:Thymine