title: [Efficacy of antibiotic prophylaxis in clean neurosurgical operations: a comparison of seven-day versus one-day administration].
abstract: We compared seven-day and one-day administration of antibiotics as prophylaxis in clean neurosurgical operations. A total of 175 patients were examined. Seven-day administration (protocol A) was studied retrospectively from May 1997 to May 1998 in 87 patients of 46 craniotomies and 41 burr hole operations. One-day administration (protocol B) was studied prospectively from June 1998 to July 1999 in 88 patients of 39 craniotomies and 49 burr hole operations. Protocol A received 1.5 g of sulbactam/ampicillin = 1:2 (SBT/ABPC) preoperatively, and further doses were continued at 12-hour intervals for seven days after the operation. Protocol B received 1.5 g of SBT/ABPC preoperatively and intraoperative additional antibiotics were administered at 5-hour intervals, and only one single dose was administered after the operation. In both of the protocols, 60 mg of tobramycin was mixed with 500 ml of saline for irrigation of operative fields. No postoperative infection occurred in either of the two protocols. We conclude that one-day administration of prophylactic antibiotics is enough to prevent postoperative infections in clean neurosurgical operations.
authors.affiliation: Department of Neurosurgery, Iwate Prefectural Iwai Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Fujiwara
authors.forename: S
authors.initials: S
authors.lastname: Suda
authors.forename: T
authors.initials: T
authors.lastname: Ebina
mesh_terms: D000667:Ampicillin / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D006801:Humans; D019635:Neurosurgical Procedures; D011182:Postoperative Care; D011446:Prospective Studies; D012189:Retrospective Studies; D013407:Sulbactam / Q000008:administration & dosage; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage*
chemical_list: C035444:sultamicillin; D000667:Ampicillin; D013407:Sulbactam; D014031:Tobramycin