An efficient, stereospecific synthesis of the dimer-selective retinoid X receptor modulator (2E,4E,6Z)-7-[5,6,7,8- tetrahydro-5,5, 8,8-tetramethyl-2-(n-propyloxy)naphthalen-3-yl]-3-methyl octa-2,4, 6-trienoic acid.
Hamann
L G
LG
Department of Medicinal Chemistry, Ligand Pharmaceuticals, Inc., 10275 Science Center Drive, San Diego, California 92121, USA. lawrence.hamann@bms.com
D002855:Chromatography, Thin Layer; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D018168:Receptors, Retinoic Acid / Q000737:chemistry*; D047488:Retinoid X Receptors; D012176:Retinoids / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis*; D014157:Transcription Factors / Q000737:chemistry*
C101596:LG 100754; D008024:Ligands; D018168:Receptors, Retinoic Acid; D047488:Retinoid X Receptors; D012176:Retinoids; D013764:Tetrahydronaphthalenes; D014157:Transcription Factors