Odorant inhalation affects skin barrier homeostasis in mice and humans.
Previous studies have suggested that psychological stress delays cutaneous barrier recovery following acute barrier disruption, and that sedative drugs block this delay. A sedative effect of some odorants has been reported. In the present study, we demonstrate that odorant inhalation affects cutaneous barrier homeostasis in both mice and humans. Odorants with a sedative effect prevented the delay of skin barrier recovery induced by stress after acute barrier disruption. Other odorants did not show this effect.
Denda
M
M
Shiseido Research Center 2, 2-12-1 Fukuura, Kanazawa-ku, Yokohama 236-8643, Japan. mitsuhiro.denda@to.shiseido.co.jp
Tsuchiya
T
T
Shoji
K
K
Tanida
M
M
D000280:Administration, Inhalation; D000328:Adult; D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D004780:Environment, Controlled; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D009822:Oils, Volatile / Q000494:pharmacology*; D012879:Skin Physiological Phenomena / Q000187:drug effects*; D012881:Skin Temperature / Q000187:drug effects; D013315:Stress, Psychological / Q000209:etiology
D001555:Benzene Derivatives; D006993:Hypnotics and Sedatives; D009822:Oils, Volatile