[Uterine and placental vascular lesions in pregnancy induced hypertension and its relationship to pregnancy outcome].
OBJECTIVE
To study the vascular lesions of the uterus and placenta in severe pregnancy induced hypertension (SPIH) and its relationship to pregnancy outcomes.


METHODS
29 cases of SPIH and 29 cases of normal term pregnancies (NTP) were examined to observe the expressions of IgA, IgG, IgM and C3 in the vascular walls of placental villus and uterus placental bed by immunohistochemical technique.


RESULTS
(1) In SPIH, the positive expression rates of the IgA, IgG, IgM and C3 in the vascular wall of placental villus (20.1%, 24.1%, 72.4%, and 65.5%) and uterus placental bed (20.0%, 20.0%, 70.0% and 60.0%) were significantly higher than those of NTP (all P < 0.05), while there were no expression in NTP. (2) The thickening of endangium angiostenosis, fibronoid necrosis and acute arterial atherosis were found at the sites of positive expressions in SPIH. (3) In SPIH complicated by intrauterine growth retardation (IUGR), the positive expressions of the immunocomplex and complement in the vessel walls (76.2%) were significantly higher than those of the SPIH without IUGR (50%, all P < 0.05).


CONCLUSIONS
In SPIH, there are depositions of immunocomplex and complement on the vessel walls of placental villus and uteroplacenta. Immunological factor plays an important role in the development of PIH.
Yin
L
L
Tianjin Medical University Second Hospital.
Han
J
J
Ma
H
H
D000328:Adult; D002824:Chorionic Villi / Q000378:metabolism / Q000473:pathology; D003176:Complement C3 / Q000096:biosynthesis; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007150:Immunohistochemistry; D010920:Placenta / Q000098:blood supply* / Q000378:metabolism; D011225:Pre-Eclampsia / Q000473:pathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D014599:Uterus / Q000098:blood supply*
D003176:Complement C3; D007136:Immunoglobulins