Sclerosing inflammatory myofibroblastic tumour of the tongue: an immunohistochemical and ultrastructural study.
A case of inflammatory myofibroblastic tumour (IMT) arising in the tongue of a 27-year-old man is described. The patient presented with a solitary, well-circumscribed submucosal mass of 4 months duration. The tumour showed in its largest part a paucicellular sclerosing lesion resembling a hyalinizing granuloma surrounded by a thin rim of an admixture of myofibroblasts, plasma cells and foamy histiocytes. Myofibroblasts expressed vimentin and alpha-smooth muscle actin positive immunophenotypes. Ultrastructurally the hyaline areas were composed of abundant collagen fibres with sparse myofibroblasts. Extensive scar-like change in this IMT may be related to a traumatic insult.
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Department of Oral Surgery, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe, Saitama, Japan.
Shimoyama
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Horie
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D000328:Adult; D006104:Granuloma, Plasma Cell / Q000473:pathology; D006801:Humans; D008297:Male; D009379:Neoplasms, Muscle Tissue / Q000473:pathology*; D012598:Sclerosis; D014059:Tongue / Q000293:injuries* / Q000473:pathology; D014062:Tongue Neoplasms / Q000473:pathology*