Impact of intermittent hemodialysis variables on clinical outcomes in acute renal failure.
When hospital-acquired acute renal failure (ARF) is severe enough to require renal replacement therapy, mortality rates are extremely high, exceeding 50%. The potential impact of renal replacement therapy on clinical outcomes in ARF remains a subject of ongoing investigation and controversy. This article reviews in depth all of the clinical trials that have examined the effect of dialysis-related variables on clinical outcomes in patients with ARF requiring intermittent hemodialysis. In particular, the role of biocompatibility of dialyzer membranes, and timing, intensity, and adequacy of dialysis are discussed.
Karsou
S A
SA
Division of Nephrology, Department of Medicine, Tupper Research Institute, New England Medical Center Hospitals, Boston, MA 02111, USA.
Jaber
B L
BL
Pereira
B J
BJ
D058186:Acute Kidney Injury / Q000628:therapy*; D001672:Biocompatible Materials; D002986:Clinical Trials as Topic; D006801:Humans; D008567:Membranes, Artificial; D006435:Renal Dialysis / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
D001672:Biocompatible Materials; D008567:Membranes, Artificial