Role of macrophages in experimental malaria: VI--Effect of Freund's complete adjuvant in Plasmodium berghei infected mice.
Freund's complete adjuvant (FCA) treated group of mice when challenged with lethal Plasmodium berghei showed increased survival value; survival period (SP) and median survival day (MSD) compared to their respective control groups. K values were affected and mean parasitaemia during infection period was lower than that of control. In general survival rate after 35 days of infection was 10.5% in FCA recipients. The survival rate in a particular group of animals which received 0.2 ml FCA 3 days before challenge was 22.7%. FCA was found to contribute to increased survival of the host against P. berghei infection. The study indicates that adjuvants, like FCA induce protective immunity and future studies should include non-specific immunization against human malaria.
Pillai
C R
CR
Division of Biochemistry and Biotechnology, National Institute of Communicable Diseases, Delhi, India.
Usha Devi
C
C
D000818:Animals; D005620:Freund's Adjuvant; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008288:Malaria / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010962:Plasmodium berghei / Q000276:immunology*
D005620:Freund's Adjuvant