T cell-mediated paraneoplastic ganglionitis--an autopsy case.
A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.
Drlicek
M
M
Ludwig Boltzmann Institut für Neuroonkologie, Linz, Austria. marcus.drlicek@wj.lkh.ooe.gv.at
Bodenteich
A
A
Setinek
U
U
Tucek
G
G
Urbanits
S
S
Grisold
W
W
D001323:Autoantibodies / Q000276:immunology; D051959:ELAV Proteins; D017809:Fatal Outcome; D005260:Female; D005727:Ganglia, Spinal / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology / Q000473:pathology*; D016601:RNA-Binding Proteins / Q000032:analysis; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D051959:ELAV Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins