Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy.
The authors enrolled 1,029 patients with CD4 counts </= 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.
d'Arminio Monforte
A
A
Institute of Infectious and Tropical Diseases, University of Milan, Italy. a-darm1@mailserver.unimi.it
Duca
P G
PG
Vago
L
L
Grassi
M P
MP
Moroni
M
M
D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000188:drug therapy*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D012307:Risk Factors
D019380:Anti-HIV Agents