title: Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances revealed with a Coulochem electrode array system.
abstract: The relationship between age and cerebrospinal fluid concentrations of monoamine-related substances, including kynurenine, were investigated using a Coulochem electrode array system, to clarify developmental changes in monoamine-related substances in the human central nervous system. In neurologically normal children, significant inverse correlations with age were observed for the cerebrospinal fluid concentrations of 5-hydroxytryptophan, 5-hydroxyindole-acetic acid, kynurenine, homovanillic acid, 3-methoxy-4-hydroxyphenyl glycol, and 3-O-methyl-dopamine. The concentrations of their precursors, tryptophan and tyrosine, were not related to age. This is the first comprehensive study revealing developmental changes in monoamine-related substances including their precursors and metabolites.
authors.affiliation: Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan. takeuchi@koto.kpu-m.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: H
authors.initials: H
authors.lastname: Matsushita
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: H
authors.initials: H
authors.lastname: Kawano
authors.forename: K
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: T
authors.initials: T
authors.lastname: Sawada
mesh_terms: D000367:Age Factors; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D004566:Electrodes; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007737:Kynurenine / Q000134:cerebrospinal fluid*; D008297:Male; D018377:Neurotransmitter Agents / Q000134:cerebrospinal fluid
chemical_list: D015306:Biogenic Monoamines; D018377:Neurotransmitter Agents; D007737:Kynurenine