title: An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists.
authors.affiliation: Neuroscience Research Centre, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, UK.
authors.forename: R T
authors.initials: RT
authors.lastname: Lewis
authors.forename: T
authors.initials: T
authors.lastname: Ladduwahetty
authors.forename: K J
authors.initials: KJ
authors.lastname: Merchant
authors.forename: L E
authors.initials: LE
authors.lastname: Keown
authors.forename: L
authors.initials: L
authors.lastname: Hitzel
authors.forename: H
authors.initials: H
authors.lastname: Verrier
authors.forename: G I
authors.initials: GI
authors.lastname: Stevenson
authors.forename: A M
authors.initials: AM
authors.lastname: MacLeod
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis*; D002151:Calorimetry; D003979:Diazonium Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010080:Oxazoles / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013373:Substance P / Q000037:antagonists & inhibitors*
chemical_list: D000438:Alcohols; D003979:Diazonium Compounds; D010080:Oxazoles; D010880:Piperidines; D013373:Substance P