title: Scanning electron microscopic observations on advanced third-stage larva of Gnathostoma spinigerum after in vitro exposure to albendazole sulphoxide.
abstract: Gnathostomiasis is the parasitic disease caused by the migration of an advanced third-stage larva of Gnathostoma spinigerum. To date, albendazole is claimed to be the effective drug in preventing the reoccurrence of migratory swelling in patients. After being exposed to 1 and 2 micrograms/ml albendazole sulphoxide (AlbSO) in vitro, the parasites moved deteriorately, however, no dead larva was found even exposed to these concentrations for 21 consecutive days. The topographical alterations after 21 days of albendazole sulphoxide exposure are described using a scanning electron microscope. The marked changes in surface morphology were observed in both neck and body regions. The tegumental surface on the neck region was swollen and covered with fuzzy materials, whereas, the spines on the posterior region of the body were dislodged. These changes would probably lead to reduction of intermittent cutaneous migratory swelling in human gnathostomiasis patients.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: K
authors.initials: K
authors.lastname: Sukontason
authors.forename: P
authors.initials: P
authors.lastname: Klaolaor
authors.forename: K
authors.initials: K
authors.lastname: Sukontason
authors.forename: B
authors.initials: B
authors.lastname: Kuntalue
authors.forename: P
authors.initials: P
authors.lastname: Vanittanakom
authors.forename: U
authors.initials: U
authors.lastname: Chaithong
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006039:Gnathostoma / Q000187:drug effects* / Q000302:isolation & purification / Q000648:ultrastructure*; D006801:Humans; D007814:Larva / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D000871:Anthelmintics; D015766:Albendazole