title: Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis.
abstract: In a pilot study, we identified Chlamydia pneumoniae in the cerebrospinal fluid by polymerase chain reaction in 5 of 10 patients with definite multiple sclerosis (MS). In a second series, 2 of 20 patients with definite MS and 3 of 17 patients with possible/probable MS or MS variants, but none of 56 patients with other neurological, diseases were polymerase chain reaction-positive. We confirm that C. pneumoniae can be found in the cerebrospinal fluid of MS patients, but our rate of positive results is lower than in a recent report.
authors.affiliation: Department of Microbiology, University of Heidelberg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Layh-Schmitt
authors.forename: C
authors.initials: C
authors.lastname: Bendl
authors.forename: U
authors.initials: U
authors.lastname: Hildt
authors.forename: T
authors.initials: T
authors.lastname: Dong-Si
authors.forename: E
authors.initials: E
authors.lastname: Jüttler
authors.forename: P
authors.initials: P
authors.lastname: Schnitzler
authors.forename: C
authors.initials: C
authors.lastname: Grond-Ginsbach
authors.forename: A J
authors.initials: AJ
authors.lastname: Grau
mesh_terms: D000293:Adolescent; D000328:Adult; D002690:Chlamydia Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000175:diagnosis; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D004269:DNA, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology; D009187:Myelitis / Q000134:cerebrospinal fluid / Q000382:microbiology; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid / Q000382:microbiology; D010865:Pilot Projects; D016133:Polymerase Chain Reaction
chemical_list: D004269:DNA, Bacterial