Caloric restriction prevents oxidative damage induced by the carcinogen clofibrate in mouse liver.
Long-term caloric restriction in rodents is known to decrease levels of oxidative damage, which may contribute to an 'anti-ageing' effect. We show here that a shorter period (10 months) of caloric restriction had only small effects on levels of oxidative DNA and protein damage in the livers of mice, but completely attenuated increased oxidative damage caused by the carcinogen clofibrate. Since clofibrate is thought to exert its actions by increasing oxidative damage, our data suggest that 10 months of caloric restriction can increase the resistance of tissues to agents inducing oxidative stress. This may be an important factor in explaining how caloric restriction decreases cancer incidence.
Qu
B
B
Department of Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore, Singapore.
Halliwell
B
B
Ong
C N
CN
Lee
B L
BL
Li
Q T
QT
D000080242:8-Hydroxy-2'-Deoxyguanosine / Q000031:analogs & derivatives; D042962:Acyl-CoA Oxidase; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D002994:Clofibrate / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000235:genetics; D002149:Energy Intake; D005508:Food Deprivation; D006147:Guanine / Q000031:analogs & derivatives / Q000032:analysis; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D020675:Peroxisomes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D002273:Carcinogens; D004272:DNA, Mitochondrial; D009687:Nuclear Proteins; D006147:Guanine; C078307:8-oxo-7,8-dihydrodeoxyguanine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase; D002994:Clofibrate