T-cell memory: lessons from Epstein-Barr virus infection in man.
Epstein-Barr virus offers an ideal opportunity to follow the human T-cell response to a virus infection over time from its acute primary phase, as seen in infectious mononucleosis patients, into the memory phase that accompanies life-long virus persistence. Here we review recent evidence on the development and maturation of cytotoxic T-cell memory using this viral system.
Rickinson
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AB
CRC Institute for Cancer Studies, University of Birmingham, Edgbaston, UK. a.b.rickinson@bham.ac.uk
Callan
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MF
Annels
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NE
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000235:genetics / Q000276:immunology*; D017735:Virus Latency / Q000276:immunology
D000956:Antigens, Viral