title: Folate sufficient subjects do not accumulate additional folates during supplementation.
abstract: In a double-blinded placebo-controlled trial of folic acid supplementation in 82 alcoholic subjects, it was found that whole blood folate levels, determined by a mass spectrometric method, do not increase in subjects whose baseline folate levels are above the third quartile (folate sufficiency). Since a state of folate sufficiency can now be identified, a recommended daily allowance (RDA) for folate can be determined using objective means.
authors.affiliation: Department of Medicine, Royal Hospital, Muscat, Oman.
authors.forename: C R
authors.initials: CR
authors.lastname: Santhosh-Kumar
authors.forename: J S
authors.initials: JS
authors.lastname: Bisping
authors.forename: S D
authors.initials: SD
authors.lastname: Kick
authors.forename: J C
authors.initials: JC
authors.lastname: Deutsch
authors.forename: J F
authors.initials: JF
authors.lastname: Kolhouse
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000437:Alcoholism; D004311:Double-Blind Method; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood*; D005494:Folic Acid Deficiency / Q000097:blood / Q000188:drug therapy*; D006397:Hematinics / Q000008:administration & dosage* / Q000097:blood*; D006801:Humans; D008297:Male
chemical_list: D006397:Hematinics; D005492:Folic Acid