A novel translocation (17;19)(p13;p13) in a patient with acute myelomonocytic leukemia.
We report on a patient with acute myeloid leukemia (AML M4) and a so far unrecorded translocation (17;19). The leukemia transformed from a myeloproliferative disorder (MPD) and showed a progressive fatal course. Following transformation, all leukemic cells showed an apparently balanced translocation (17;19)(p13;p13). The breakpoint regions harbor genes such as TP53 (17p13) and E2A, ENL, or LYL1 (19p13), which could be relevant in leukemogenesis. We suspect that the translocation (17;19)(p13;p13) may be a prognostic factor for transformation from chronic MPD to acute leukemia.
Brückner
R
R
Department of Human Genetics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Jentsch-Ullrich
K
K
Franke
A
A
Wieacker
P
P
Stumm
M
M
D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015479:Leukemia, Myelomonocytic, Acute / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic