Fertility: purinergic receptors and the male contraceptive pill.
Knockout mice lacking the P2X(1) receptor appear normal, but fail to breed. Analysis of these mutant mice clearly shows that purinergic co-transmission has a physiological role in the was deferens. These findings also raise the possibility of developing non-hormonal ways of regulating male fertility.
Dunn
P M
PM
Department of Anatomy and Development Biology, Autonomic Neuroscience Institute, Royal Free and University College Medical School, London, NW3 2PF, UK.
D000255:Adenosine Triphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology; D015195:Drug Design; D004558:Electric Stimulation; D005298:Fertility / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011224:Prazosin / Q000494:pharmacology; D018048:Receptors, Purinergic P2 / Q000172:deficiency / Q000187:drug effects / Q000235:genetics*; D058469:Receptors, Purinergic P2X; D014649:Vas Deferens / Q000502:physiology*
D000317:Adrenergic alpha-Antagonists; D003272:Contraceptive Agents, Male; D018048:Receptors, Purinergic P2; D058469:Receptors, Purinergic P2X; D000255:Adenosine Triphosphate; C002630:alpha,beta-methyleneadenosine 5'-triphosphate; D011224:Prazosin