title: Pyridoxine (vitamin B6) supplementation in pregnancy.
abstract: BACKGROUND
  Pyridoxine (vitamin B6) contributes to the development of the central nervous system and may influence brain development and cognitive function. It may also prevent dental caries and protect the placental vascular bed.
  
  
  OBJECTIVE
  The objective of this review was to assess the effects of vitamin B6 supplementation during pregnancy and labour.
  
  
  METHODS
  We searched the Cochrane Pregnancy and Childbirth Group trials register.
  
  
  METHODS
  Randomised trials of pyridoxine administration compared to a control group.
  
  
  METHODS
  Trial quality was assessed and data were extracted by two reviewers.
  
  
  RESULTS
  One trial involving 371 women was included. Pyridoxine supplementation either as oral capsules (odds ratio 0.63, 95% confidence interval 0. 41 to 0.95) or lozenges (odds ratio 0.33, 95% confidence interval 0. 22-0.51) was associated with decreased incidence of dental decay in pregnant women.
  
  
  CONCLUSIONS
  There is not enough evidence to evaluate pyridoxine supplementation during pregnancy, although the results of one trial suggest that it may have a beneficial effect on dental decay.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Zimbabwe, PO Box A178, Avondale, Harare, Zimbabwe. kmahomed@healthnet.zw
authors.forename: K
authors.initials: K
authors.lastname: Mahomed
authors.forename: A M
authors.initials: AM
authors.lastname: Gulmezoglu
mesh_terms: D019587:Dietary Supplements; D005260:Female; D006801:Humans; D011247:Pregnancy; D011736:Pyridoxine
chemical_list: D011736:Pyridoxine