title: Managing the complications of cirrhosis.
abstract: The 3 major and potentially fatal complications of cirrhosis of the liver result from portal hypertension and include variceal bleeding, ascites, and encephalopathy. The cause of other complications, eg, thyroid dysfunction and hepatopulmonary syndrome, is uncertain. Several recent advances have occurred in the treatment of varices. However, treatment of ascites is still primarily confined to achieving a negative sodium balance, and therapy for encephalopathy centers on the use of lactulose. Although effective therapy may be available for most complications of cirrhosis, a major complication indicates a poor long-term prognosis. Liver transplantation is the only effective long-term treatment of complications due to cirrhosis.
authors.affiliation: Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic Rochester, MN 55905, USA.
authors.forename: K V
authors.initials: KV
authors.lastname: Menon
authors.forename: P S
authors.initials: PS
authors.lastname: Kamath
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D004724:Endoscopy; D004932:Esophageal and Gastric Varices / Q000150:complications / Q000517:prevention & control; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000517:prevention & control; D006501:Hepatic Encephalopathy / Q000175:diagnosis / Q000628:therapy; D020065:Hepatopulmonary Syndrome / Q000150:complications; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D007037:Hypothyroidism / Q000150:complications; D008103:Liver Cirrhosis / Q000150:complications* / Q000601:surgery; D010538:Peritonitis; D011379:Prognosis; D015911:Sclerotherapy
chemical_list: D000319:Adrenergic beta-Antagonists