title: Aldol reaction under solvent-free conditions: highly stereoselective synthesis of 1,3-amino alcohols
abstract: [formula: see text] A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.initials: TP
authors.lastname: Loh
authors.initials: JM
authors.lastname: Huang
authors.initials: SH
authors.lastname: Goh
authors.initials: JJ
authors.lastname: Vittal