title: Parallel Synthesis of Alkyl Tetrazole Derivatives Using Solid Support Chemistry.
abstract: The synthesis of several omega-chloroalkyl tetrazoles and their subsequent attachment to a solid support is described. Using an in situ Finkelstein reaction, a variety of nucleophiles were alkylated and then cleaved from the resin to give pure alkyl tetrazole derivatives. A sample library of 5 x 6 demonstrates the general utility of this sequence.
authors.affiliation: Discovery Chemistry Research, Eli Lilly and Company, Indianapolis, Indiana 46285, DePauw University, Greencastle, Indiana, and Parker H. Petit Institute for Bioengineering and Biosciences, Atlanta, Georgia.
authors.initials: DP
authors.lastname: Matthews
authors.initials: JE
authors.lastname: Green
authors.initials: AJ
authors.lastname: Shuker