title: [Serotonin metabolism in the rat brain during water deprivation and hydration].
abstract: Water deprivation (WD) decreased the serotonin (5-HT) level and significantly increased the 5-hydroxyindoleacetic acid (5-HIAA) in the rat midbrain and hypothalamus, the catabolic 5-HIAA/5-HT ratio increasing three-fold. Hydration (H) produced a moderate increase in the 5-HT and 5-HIAA levels in the hypothalamus with no changes in the 5-HIAA/5-HT ratio. Hydration exerted no significant effect upon the 5-HT level and metabolism in the midbrain. A two-fold increase of corticosterone concentration in water deprivation and its decrease in hydration were shown to occur in peripheral blood plasma.
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of the Russian Acad. Sci., Novosibirsk.
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
authors.forename: L N
authors.initials: LN
authors.lastname: Ivanova
authors.forename: T G
authors.initials: TG
authors.lastname: Amstislavskaia
authors.forename: N N
authors.initials: NN
authors.lastname: Melidi
authors.forename: K S
authors.initials: KS
authors.lastname: Naumenko
authors.forename: L N
authors.initials: LN
authors.lastname: Maslova
authors.forename: V V
authors.initials: VV
authors.lastname: Bulygina
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004326:Drinking; D004327:Drinking Behavior; D006706:Homeostasis; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007038:Hypotonic Solutions; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013395:Sucrose / Q000008:administration & dosage; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
chemical_list: D007038:Hypotonic Solutions; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D013395:Sucrose