Prions: Portable prion domains.
Self-propagating abnormal proteins, prions, have been identified in yeast; asparagine/glutamine-rich 'prion domains' within these proteins can inactivate the linked functional domains; new prion domains and reporters have been used to make 'synthetic prions', leading to discoveries of new natural prions.
Wickner
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RB
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, 20892-0830, USA. wickner@helix.nih.gov
Taylor
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KL
Edskes
H K
HK
Maddelein
M L
ML
D000818:Animals; D001665:Binding Sites; D005656:Fungal Proteins / Q000378:metabolism*; D005979:Glutathione Peroxidase; D010454:Peptide Termination Factors; D011328:Prions / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
D005656:Fungal Proteins; D010454:Peptide Termination Factors; D011328:Prions; C068068:SUP35 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D005979:Glutathione Peroxidase; C067020:URE2 protein, S cerevisiae