title: Indocyanine green angiography of well-defined plaque choroidal neovascularization in age-related macular degeneration.
abstract: OBJECTIVE
  To determine the natural course of well-defined plaque choroidal neovascularization (CNV) using indocyanine green angiography.
  
  
  METHODS
  Two ophthalmologists, experts in macular diseases and indocyanine green angiography, examined 40 eyes with exudative age-related macular degeneration and a well-defined plaque CNV using complete ophthalmoscopic evaluation, fluorescein angiography, and indocyanine green angiography. The increase in the size of the plaques was analyzed using multivariate analysis, in relation to the worsening of visual acuity, with adjustment for age, sex, and length of follow-up.
  
  
  RESULTS
  Mean follow-up was 13.5 months (median, 11 months). Initial and final mean visual acuity were 20/46 (median, 20/50) and 20/65 (median, 20/100), respectively. The mean initial size of the plaque was 6.62 mm2 (median, 6.20 mm2), and the mean final size was 10.40 mm2 (median, 9.76 mm2). The enlargement was statistically significant (P<.001).
  
  
  CONCLUSIONS
  We found that plaque CNV tends to become larger with time, the enlargement reaching about 40% in 1 year of follow-up. The resulting loss of visual acuity, however, is not significant, and is slightly correlated with the extension of the lesion; it also does not appear to be directly related to sex.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Scientific Institute H San Raffaele, University of Milano, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pece
authors.forename: G
authors.initials: G
authors.lastname: Bolognesi
authors.forename: U
authors.initials: U
authors.lastname: Introini
authors.forename: G
authors.initials: G
authors.lastname: Pacelli
authors.forename: G
authors.initials: G
authors.lastname: Calori
authors.forename: R
authors.initials: R
authors.lastname: Brancato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green; D008268:Macular Degeneration / Q000150:complications / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity
chemical_list: D007208:Indocyanine Green