Immunologic methods of purging in autologous stem cell transplantation.
Malignant cells in the stem cell product have been shown to contribute to disease recurrence in patients who relapse after autologous transplantation. Immunologic methods of purging tumor cells from stem cell products focus on either removal of specific target cells or positive selection of HPC. mAb are the key component of many purging strategies and are employed both in vitro and in vivo. Cytotoxic cellular therapies are an emerging method of tumor cell eradication.
Berkahn
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Section of Bone Marrow Transplant and Cell Therapy, Rush-Presbyterian St. Luke's Medical Center, Rush Medical College, Chicago, IL 60612, USA.
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D016465:Bone Marrow Purging / Q000379:methods*; D003602:Cytotoxicity, Immunologic; D019337:Hematologic Neoplasms / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation; D008223:Lymphoma / Q000628:therapy; D055502:Secondary Prevention; D014182:Transplantation, Autologous / Q000379:methods
D000911:Antibodies, Monoclonal