Synthesis of 3-ethoxycarbonyl-4-hydroxyquinoline N-oxides from the Baylis-Hillman adducts of o-nitrobenzaldehydes
[reaction: see text] The reaction of the Baylis-Hillman adducts la-e of o-nitrobenzaldehydes and trifluoroacetic acid at 60-70 degrees C gave 3-ethoxycarbonyl-4-hydroxyquinoline N-oxide derivatives 3a-e in good to moderate yields.
Kim
JN
Department of Chemistry, Chonnam National University, Kwangju, Korea. kimjn@chonnam.chonnam.ac.kr
Lee
KY
Kim
HS
Kim
TY