title: Fish oil supplementation improves docosahexaenoic acid status of malnourished infants.
abstract: OBJECTIVE
  To investigate whether the low docosahexaenoic acid (DHA) status of malnourished, mostly breast fed, Pakistani children can be improved by fish oil (FO) supplementation.
  
  
  METHODS
  Ten malnourished children (aged 8-30 months) received 500 mg FO daily for nine weeks. The supplement contained 62.8 mol% (314 mg) long chain polyunsaturated fatty acids of the omega3 series (LCPUFAomega3) and 22.5 mol% (112 mg) DHA. Seven FO unsupplemented children served as controls. Red blood cell (RBC) fatty acids were analysed at baseline and at the study end.
  
  
  RESULTS
  FO supplementation augmented mean (SD) RBC DHA from 2.27 (0.81) to 3.35 (0.76) mol%, without significantly affecting the concentrations of LCPUFAomega6. Unsupplemented children showed no RBC fatty acid changes. One FO supplemented child with very low initial RBC arachidonic acid showed a remarkable increase from 4.04 to 13.84 mol%, whereas another with high RBC arachidonic acid showed a decrease from 15.64 to 10.46 mol%.
  
  
  CONCLUSIONS
  FO supplementation improves the DHA status of malnourished children. The supplement is apparently well absorbed and not exclusively used as a source of energy.
authors.affiliation: Department of Obstetrics and Gynecology/Pediatrics, Perinatal Nutrition and Development Unit, University Hospital Groningen, Dept CMC 5, kY3179, PO Box 30.001, 9700 RB Groningen, Netherlands.
authors.forename: E N
authors.initials: EN
authors.lastname: Smit
authors.forename: E A
authors.initials: EA
authors.lastname: Oelen
authors.forename: E
authors.initials: E
authors.lastname: Seerat
authors.forename: E R
authors.initials: ER
authors.lastname: Boersma
authors.forename: F A
authors.initials: FA
authors.lastname: Muskiet
mesh_terms: D001942:Breast Feeding / Q000009:adverse effects; D002675:Child, Preschool; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry; D005395:Fish Oils / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D009748:Nutrition Disorders / Q000178:diet therapy* / Q000209:etiology
chemical_list: D005395:Fish Oils; D004281:Docosahexaenoic Acids