title: New diffusion-edited NMR experiments to expedite the dereplication of known compounds from natural product mixtures.
abstract: [reaction: see text] We present two new diffusion-edited NMR experiments, improved DECODES and HETDECODES, that sort the constituents in a mixture by their individual diffusion coefficients. These experiments should allow the partial NMR spectral assignment and cursory structure elucidation of compounds in a complex mixture as an aid in the dereplication of known or nuisance compounds.
authors.affiliation: College of Pharmacy, Oregon State University, Corvallis 97331, USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Williamson
authors.forename: E L
authors.initials: EL
authors.lastname: Chapin
authors.forename: A W
authors.initials: AW
authors.lastname: Carr
authors.forename: J R
authors.initials: JR
authors.lastname: Gilbert
authors.forename: P R
authors.initials: PR
authors.lastname: Graupner
authors.forename: P
authors.initials: P
authors.lastname: Lewer
authors.forename: P
authors.initials: P
authors.lastname: McKamey
authors.forename: J R
authors.initials: JR
authors.lastname: Carney
authors.forename: W H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification*; D001709:Biotechnology; D000458:Cyanobacteria / Q000737:chemistry; D004058:Diffusion; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*
chemical_list: D001685:Biological Factors; D007306:Insecticides