title: Transcriptional augmentation: modulation of gene expression by scaffold/matrix-attached regions (S/MAR elements).
abstract: For a long time S/MARs could only be characterized by the assays in vitro that led to their detection. Only recently a number of biological activities emerged that are common to most or all S/MARs that are detected by the classic procedures. This review focuses on the phenomenon of transcriptional augmentation that is found for genomically anchored or episomal genes and on a group of partially overlapping activities that are suited to maintain an episomal status. Further, it is attempted to correlate properties of the S/MAR-scaffold interaction with prominent or prototype protein binding partners.
authors.affiliation: GBF, National Center for Biotechnological Research, Braunschweig.
authors.forename: J
authors.initials: J
authors.lastname: Bode
authors.forename: C
authors.initials: C
authors.lastname: Benham
authors.forename: A
authors.initials: A
authors.lastname: Knopp
authors.forename: C
authors.initials: C
authors.lastname: Mielke
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D015530:Nuclear Matrix / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D010957:Plasmids; D011485:Protein Binding; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D009687:Nuclear Proteins