Differences in reactivity to vitamin K administration of the vitamin K-dependent procoagulant factors, protein C and S, and osteocalcin.
Vitamin K is a trace nutrient necessary not only for the synthesis of four plasma clotting factors but also the production of two important anticlotting factors, protein C and protein S, and the synthesis of two bone proteins. If protein C and protein S are produced more quickly and/or in higher quantities than four plasma coagulation factors after vitamin K administration, then the result is unfavorable for stopping of hemorrhage. We therefore studied the difference of time dependence of prothrombin procoagulant factors, protein C and S and bone Gla protein after the administration of vitamin K in normal and vitamin K-deficient neonates. Results of our study showed that, on the whole, coagulation factors increased markedly more than anticlotting factors after vitamin K administration. Furthermore, the increase in bone Gla protein was also higher compared with protein C activity, although the detailed mechanism of the difference in reactivity of prothrombin procoagulant factors, protein C and S and bone Gla protein to vitamin K administration is not clear.
Shirakawa
Y
Y
Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu City, Fukuoka Pref, Japan.
Shirahata
A
A
Fukuda
M
M
D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood; D008297:Male; D015675:Osteocalcin / Q000096:biosynthesis* / Q000235:genetics; D011486:Protein C / Q000096:biosynthesis* / Q000235:genetics; D017293:Protein S / Q000096:biosynthesis* / Q000235:genetics; D014812:Vitamin K / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D014813:Vitamin K Deficiency / Q000097:blood* / Q000151:congenital / Q000188:drug therapy / Q000209:etiology
D011486:Protein C; D017293:Protein S; D015675:Osteocalcin; D014812:Vitamin K