title: Size makes a difference: use of a low-prime cardiopulmonary bypass circuit and autologous priming in small adults.
abstract: Low hematocrit (Hct < 20) during cardiopulmonary bypass (CPB) is associated with higher mortality and other adverse outcomes. More frequently, low Hct is encountered in patients with small body size and women patients. This prompted us to take an aggressive approach in our care of these patients, involving a strategy for predicting patients at risk of low Hct, with the aid of an electronic worksheet that accurately predicts CPB Hct, and two prevention strategies: use of a low-prime CPB circuit (LP) for all adult patients with a body surface area (BSA) < 1.7 m(2) and use of autologous circuit priming (AP), in addition to the low-circuit volume in some patients. The two cohorts of patients in whom these techniques were employed were compared to a group matched for body size where our standard adult circuit (STD) was used. There were 233 patients in the standard group, 139 in the LP group, and 68 in the LP/AP group. The CPB circuit prime volume was 1,710 ml for the STD group and 1,110 ml for the LP group. Use of autologous priming techniques further reduced the prime volume by 545 +/- 139 ml. The incidence of low Hct (<20%) during CPB was thus reduced from 70% to 15% (p = 0.001) when using both techniques together without increasing red blood cell (RBC) transfusions. These changes in perfusion management resulted in a reduction in the incidence of renal complications (STD = 9.4%, LP = 6.5% (ns) and LP/AP = 0%,
authors.affiliation: Cardiac Surgery Department, Maine Medical Center, Portland 04102, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Cormack
authors.forename: R J
authors.initials: RJ
authors.lastname: Forest
authors.forename: R C
authors.initials: RC
authors.lastname: Groom
authors.forename: J
authors.initials: J
authors.lastname: Morton
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001804:Blood Transfusion, Autologous; D001810:Blood Volume; D001824:Body Constitution; D001827:Body Height; D001835:Body Weight; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D004867:Equipment Design; D005069:Evaluation Studies as Topic; D005260:Female; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male