Administration of endotoxin associated with lipopolysaccharide tolerance protects mice against fungal infection.
Lipopolysaccharide (LPS) pretreatment of mice resulted in a significantly enhanced survival after disseminated Cryptococcus neoformans infection. The survival was associated with reduced fungal burden in tissues. LPS-pretreated mice had lower levels of cytokines in blood, spleen, and lungs and higher levels in brain. Pentoxifylline abolished the beneficial effect of LPS pretreatment.
Rayhane
N
N
Unité d'Immuno-Allergie, Institut Pasteur, 75015 Paris, France.
Fitting
C
C
Lortholary
O
O
Dromer
F
F
Cavaillon
J M
JM
D000818:Animals; D001921:Brain / Q000382:microbiology; D003453:Cryptococcosis / Q000097:blood / Q000401:mortality / Q000517:prevention & control*; D016207:Cytokines / Q000097:blood; D004731:Endotoxins / Q000627:therapeutic use*; D008070:Lipopolysaccharides / Q000627:therapeutic use*; D008168:Lung / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010431:Pentoxifylline / Q000494:pharmacology; D013154:Spleen / Q000382:microbiology
D016207:Cytokines; D004731:Endotoxins; D008070:Lipopolysaccharides; D010431:Pentoxifylline