Inherited risk factors for venous thromboembolism: implications for clinical practice.
Each year, thrombosis in the deep veins of the lower extremities occurs in 1 of every 1000 Americans (1). Although most cases of venous thrombosis are not fatal, death from pulmonary embolism can be expected in 1% to 2% of all patients, and as many as 25% of patients with deep venous thrombosis (DVT) will suffer the chronic effects of postthrombotic syndrome. Thus, identification of high-risk patients with genetic predispositions to thrombosis is an important clinical goal, particularly among individuals with recurrent DVT.
Ridker
P M
PM
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, USA.
D005194:Family Practice; D020022:Genetic Predisposition to Disease; D006801:Humans; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000235:genetics*