title: [Photoactivated derivatives of peptide and protein ligands in the studies of neuroreceptors].
abstract: The application of photoactivatable derivatives for studies of different types of neuroreceptors belonging to two superfamilies, G-protein dependent receptors and ligand-gated ionic channels, is discussed. Studies of the structure of voltage-gated and ion-gated channels with the use of specific photoactivatable derivatives of neurotoxins are also described. Possibilities and prospects for the application of photoactivatable ligands in studies of the spatial structure of neuroreceptors are reviewed.
authors.affiliation: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. utkin@ibch.siobc.ras.ru
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Utkin
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D009420:Nervous System / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry*; D010775:Photic Stimulation; D011506:Proteins / Q000737:chemistry*; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007473:Ion Channels; D008024:Ligands; D010455:Peptides; D011506:Proteins; D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins