title: Association of infiltrating lobular carcinoma with positive surgical margins after breast-conservation therapy.
abstract: OBJECTIVE
  To determine whether infiltrating lobular carcinoma (ILC) is associated with high positive-margin rates for single-stage lumpectomy procedures, and to define clinical, mammographic, or histologic characteristics of ILC that might influence the positive-margin rate, thereby affecting treatment decisions.
  
  
  BACKGROUND
  Infiltrating lobular cancer represents approximately 10% of all invasive breast carcinomas and is often poorly defined on gross examination.
  
  
  METHODS
  A group of 47 patients with biopsy-proven ILC undergoing breast-conservation therapy (BCT) at the University of Virginia Health Sciences Center between 1975 and 1999 was compared with a group of 150 patients with infiltrating ductal cancer undergoing BCT during the same time period. The pathology of the lumpectomy specimen was reviewed for each patient to confirm surgical margin status. Office and surgical notes as well as mammography reports were examined to determine whether the lesions were deemed palpable before and during surgery. Patients were stratified according to age, family history, tumor size, tumor location, and histologic features of the tumor.
  
  
  RESULTS
  The incidence of positive margins was greater in the ILC group compared with the infiltrating ductal cancer group. Patient age, family history, and preoperative palpability of the tumor did not correlate with surgical margin status. Of the mammographic features identified, including spiculated mass, calcifications, architectural distortion, and other densities, only architectural distortion predicted positive surgical margin status. Tumor grade, tumor size, lymph node status, and receptor status were not predictive of surgical margin status.
  
  
  CONCLUSIONS
  For patients with ILC, BCT is feasible, but these patients are at high risk of tumor-positive resection margins (51% incidence) after the initial resection. Only the mammographic finding of architectural distortion was identified as a preoperative marker reliably identifying a subgroup of ILC patients at especially high risk for a positive surgical margin. For all patients with ILC considering BCT, careful counseling about the potential need for a second procedure to treat the positive margin should be included in the treatment discussion.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, University of Virginia, Charlottesville, Virginia 22908-0709, USA. mmm7k@virginia.edu
authors.forename: M M
authors.initials: MM
authors.lastname: Moore
authors.forename: G
authors.initials: G
authors.lastname: Borossa
authors.forename: J Z
authors.initials: JZ
authors.lastname: Imbrie
authors.forename: R E
authors.initials: RE
authors.lastname: Fechner
authors.forename: J A
authors.initials: JA
authors.lastname: Harvey
authors.forename: C L
authors.initials: CL
authors.lastname: Slingluff
authors.forename: R B
authors.initials: RB
authors.lastname: Adams
authors.forename: J B
authors.initials: JB
authors.lastname: Hanks
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008327:Mammography; D015412:Mastectomy, Segmental; D008875:Middle Aged; D012086:Reoperation; D012189:Retrospective Studies