Nutritional (n-3) polyunsaturated fatty acids influence the behavioral responses to positive events in mice.
The effect of (n-3) polyunsaturated fatty acid (PUFA) diet deficiency on behavioural responses to appetitive events was assessed in OF1 mice. Pups fed the same diet (deficient in alpha-linolenic acid or a standard control diet) as their dams were used aged 7 to 11 weeks. In a free choice model, the preference for a sucrose solution in both males and females was significantly lower in deficient than in control mice. Morphine conditioned place preference was obtained with the two diets at 8 and 16 mg/kg morphine, but the lower dose of 4 mg/kg induced a place preference in control but not in (n-3) deficient mice. Taken together, these results suggest that a nutritional (n-3) PUFA deficiency can alter the responsiveness to appetitive events.
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INSERM U26, Hôpital Fernand Widal, 200 rue du Faubourg St. Denis, 75475, Paris, France. henriette.frances@inserm.lrb.ap-hop-paris-fr
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Smirnova
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Carrié
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Debray
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Bourre
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D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D013395:Sucrose / Q000494:pharmacology*
D015525:Fatty Acids, Omega-3; D009294:Narcotics; D013395:Sucrose; D009020:Morphine