title: Glutamate uptake is decreased in platelets from Alzheimer's disease patients.
abstract: Because excitotoxicity may be involved in neurodegeneration in Alzheimer's disease, we investigated possible modifications of platelet glutamate uptake in AD patients. High-affinity glutamate uptake was studied in platelets from 35 Alzheimer's disease patients, 10 multi-infarct dementia patients, and 35 age-matched normal controls; it was decreased by 40% in platelets from Alzheimer's disease patients compared with controls and with multi-infarct dementia patients. Platelet glutamate uptake could be used as peripheral marker of glutamatergic involvement and as adjunctive diagnostic tool in Alzheimer's disease patients.
authors.affiliation: Department of Neurology, University of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Ferrarese
authors.forename: B
authors.initials: B
authors.lastname: Begni
authors.forename: C
authors.initials: C
authors.lastname: Canevari
authors.forename: C
authors.initials: C
authors.lastname: Zoia
authors.forename: R
authors.initials: R
authors.lastname: Piolti
authors.forename: M
authors.initials: M
authors.lastname: Frigo
authors.forename: I
authors.initials: I
authors.lastname: Appollonio
authors.forename: L
authors.initials: L
authors.lastname: Frattola
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D005260:Female; D005971:Glutamates / Q000097:blood / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index
chemical_list: D005971:Glutamates