Synthesis of eight-membered ring compounds using enyne metathesis
[reaction: see text] A novel procedure for synthesizing eight-membered ring compounds was developed using ruthenium-catalyzed enyne metathesis. When a CH2Cl2 solution of enyne connected with catechol, o-amino phenol, or o-phenylenediamine was stirred in the presence of benzylidene ruthenium carbene complex (10 mol %) at room temperature overnight, an eight-membered ring compound was obtained in high yield. In a similar manner, monocyclic 1,4-diaza- or 1-oxa-4-azacyclooctene derivative was obtained in high yield.
Mori
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. mori@pharm.hokudai.ac.jp
Kitamura
T
Sakakibara
N
Sato
Y