Renal dopaminergic mechanisms and hypertension: a chronology of advances.
Dopamine (DA) has been shown to influence kidney function through endogenous synthesis and subsequent interaction with locally expressed dopamine receptor subtypes (D1, D5 as D1-like and D2, D3, and D4 as D2-like). DA, and DA-receptor specific agonists and antagonists can alter renal water and electrolyte excretion along with renin release when infused systemically or intrarenally. Such effects are brought about by a combination of renal hemodynamic and direct tubular effects evoked along the full length of the nephron. The cellular mechanisms that direct these dopamine-mediated renal electrolyte fluxes have recently been clarified and include alterations in adenylyl cyclase, phospholipase C, and phospholipase A1 activity. The dopaminergic system also interacts directly with the renal kallikrein-kinin, prostaglandin and other neurohumoral systems. Aberrant renal dopamine production and/or dopamine receptor function have been reported in salt-dependent and low-renin forms of human primary hypertension as well as in genetic models of animal hypertension, including the SHR and Dahl SS rat. DA D1 or D3 receptor knockout mice have been shown to develop hypertension.
O'Connell
D P
DP
Department of Pharmacology & Therapeutics, University College Cork, Ireland.
Aherne
A M
AM
D000818:Animals; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology; D004298:Dopamine / Q000096:biosynthesis*; D018491:Dopamine Agonists / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000627:therapeutic use; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D016234:Kallikrein-Kinin System / Q000502:physiology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism; D011954:Receptors, Dopamine / Q000145:classification / Q000378:metabolism*; D012079:Renal Circulation
D015415:Biomarkers; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D011453:Prostaglandins; D011954:Receptors, Dopamine; D004298:Dopamine