Negative association between T102C polymorphism at the 5-HT2A receptor gene and bipolar affective disorders in Singaporean Chinese.
BACKGROUND
Serotonergic system abnormalities have been implicated in the pathogenesis of bipolar affective disorders. The 5-hydroxytryptamine type 2A (5HTR2A) receptor gene located on chromosome 13 (13q14-21) can be considered as a candidate gene for bipolar affective disorder (BPAD).


METHODS
Seventy-two patients with BPAD and 74 normal population controls were genotyped with restriction fragment length polymorphism (RFLP) in the 5HTR2A receptor gene.


RESULTS
We report a negative association between 5HTR2A receptor gene and BPAD. The association was examined using a case-control design. Allele and genotype frequencies as well as homozygote-heterozygote distribution at the 5HTR2A receptor gene polymorphism were compared between the two groups. There were no significant differences in the allelic or genotype frequencies and the homozygote-heterozygote distributions.


CONCLUSIONS
Patients were recruited from one hospital in Singapore. The case-control study design needs replication.


CONCLUSIONS
Our finding indicates that the 5HTR2A receptor gene polymorphism is not a major factor in the genetic susceptibility to BPAD in Singaporean Chinese.
Tut
T G
TG
Department of Psychological Medicine, National University Hospital, National University of Singapore.
Wang
J L
JL
Lim
C C
CC
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011985:Receptors, Serotonin / Q000235:genetics*; D012307:Risk Factors; D012846:Singapore
D011985:Receptors, Serotonin