Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic field.
Human serum albumin labeled with technetium-99m was encapsulated together with magnetite particles into phosphatidylcholine/cholesterol liposomes. In order to investigate the stability of this complex and its ability to be used for magnetic drug targeting, the in-vivo distribution after intravenous administration in rats was estimated. For in-vivo targeting an SmCo permanent magnet with intensity approximately 0.35 T was attached near the right kidney. Difference between the relative radioactivity in the magnetically targeted right kidney (25.92+/-5.84%) and non-targeted left kidney (0.93+/-0.05%) is sufficiently high for relevant clinical applications.
Babincová
M
M
Department of Biophysics, Comenius University, Bratislava, Slovakia. babincova@fmph.uniba.sk
Altanerová
V
V
Lampert
M
M
Altaner
C
C
Machová
E
E
Srámka
M
M
Babinec
P
P
D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism; D008081:Liposomes; D008280:Magnetics; D010599:Pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
D008081:Liposomes