Chemical synthesis of cross-linked purine nucleosides.
[reaction: see text] An efficient route to all of the possible cross-linked 2'-deoxypurines 1-3 has been developed by means of the Pd-mediated C-N bond formation in the key step. Utilizing this protocol, the synthesis of the first unnatural protected purine trimeric adduct 4 has been accomplished.
De Riccardis
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F
Department of Pharmacological Sciences, State University of New York at Stony Brook, 11794-3400, USA. dericca@unisa.it
Johnson
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F
D002273:Carcinogens / Q000494:pharmacology; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry; D018736:DNA Adducts / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry*
D002273:Carcinogens; D003432:Cross-Linking Reagents; D018736:DNA Adducts; D009705:Nucleosides; D011687:Purines; D010165:Palladium