Noninvasive monitoring of nonshunted pulmonary capillary blood flow in the acute respiratory distress syndrome.
OBJECTIVE
Noninvasive monitoring of nonshunted pulmonary capillary blood flow, using the alveolar amplitude response technique (AART) in a porcine model of the acute respiratory distress syndrome.


METHODS
Experimental animal study.


METHODS
University center for animal experiments.


METHODS
In 12 mechanically ventilated pigs, the nonshunted pulmonary capillary blood flow was varied by means of lung lavages and the application of positive end-expiratory pressure.


RESULTS
Nonshunted pulmonary capillary blood flow was determined by AART. Cardiac output (determined by the thermodilution method) corrected for venous admixture was used for comparison (r2 varied between .58 and .94; p < .01). The trend in the development of nonshunted pulmonary capillary blood flow as measured with AART was in agreement with the trend detected by cardiac output corrected for venous admixture in 92% of all events.


CONCLUSIONS
We conclude that AART can be used to monitor changes in nonshunted pulmonary capillary blood flow in cases of acute respiratory distress syndrome noninvasively and continuously.
Kanhai
K J
KJ
Department of Surgery, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Strijdhorst
H
H
Pompe
J C
JC
Holland
W P
WP
Ong
E G
EG
Puppels
G J
GJ
D000818:Animals; D018893:Bronchoalveolar Lavage; D002196:Capillaries / Q000503:physiopathology; D002302:Cardiac Output / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D008991:Monitoring, Physiologic / Q000379:methods* / Q000706:statistics & numerical data; D011175:Positive-Pressure Respiration / Q000379:methods / Q000706:statistics & numerical data; D011652:Pulmonary Circulation / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology* / Q000628:therapy; D013552:Swine; D013815:Thermodilution