Effect of nicorandil upon different guinea-pig and rat isolated organ preparations in vitro.
A study of the effect of nicorandil (N-2-(hydroxyethyl)nicotinamide nitrate, CAS 65141-46-0), a potassium channel and guanylatecyclase activator, upon preparations of rat was deferens and uterus, and guinea pig ileum was performed. Nicorandil does not modify rat isolated was deferens responses to noradrenaline (norepinephrine) and potassium. The drug exerts a non-competitive antagonist effect upon rat isolated uterus response to serotonin, histamine, oxytocin, and, at high concentrations, inhibits guinea-pig isolated ileum responses to acetylcholine, histamine, 4-aminopyridine and potassium.
Barcenilla
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A
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Spain.
Alamo
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C
Carvajal
A
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García-Pozo
J
J
Velasco
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A
D000109:Acetylcholine / Q000494:pharmacology; D000632:Aminopyrine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001464:Barium / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D020108:Nicorandil / Q000494:pharmacology*; D009928:Organ Specificity; D015221:Potassium Channels / Q000819:agonists*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015221:Potassium Channels; D014665:Vasodilator Agents; D000632:Aminopyrine; D001464:Barium; D020108:Nicorandil; D012701:Serotonin; D006632:Histamine; D000109:Acetylcholine