Tenascin in the developing and adult human intestine.
The tenascins are a family of multifunctional extracellular matrix glycoproteins subject to complex spatial and temporal patterns of expression in the course of various organogenetic processes, namely those involving epithelial-mesenchymal interactions. In the intestine, the tenascins, in particular tenascin-C, have been found to be differentially expressed in the developing and adult small intestinal and colonic mucosa as well as in neoplasm. While tenascin-C emerges as a key player likely to be involved in intestinal mucosa development, maintenance and disease, its exact role in the regulation of fundamental intestinal cell function(s) such as proliferation, migration and tissue-specific gene expression remains however to be established.
Bélanger
I
I
Department of Anatomy and Cell Biology, School of Medicine, Université de Sherbrooke, Qué, Canada.
Beaulieu
J F
JF
D000328:Adult; D000818:Animals; D006801:Humans; D007422:Intestines / Q000254:growth & development*; D019063:Tenascin / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014018:Tissue Distribution
D019063:Tenascin