title: Adxanthromycins A and B, new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule from Streptomyces sp. NA-148. II. Physico-chemical properties and structure elucidation.
abstract: Adxanthromycins A and B are new inhibitors of ICAM-1/LFA-1 mediated cell adhesion molecule isolated from the fermentation broth of Streptomyces sp. NA-148. The molecular formula of adxanthromycins A and B were determined as C42H40O17 and C48H50O22, respectively by FAB-MS and NMR spectral analyses, and the structures of both compounds were elucidated to be a dimeric anthrone peroxide skeleton containing alpha-D-galactose by various NMR spectral analyses and chemical degradation.
authors.affiliation: Department of Biosciences, Teikyo University, Utsunomiya, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Koiwa
authors.forename: T
authors.initials: T
authors.lastname: Noshita
authors.forename: S
authors.initials: S
authors.lastname: Funayama
authors.forename: H
authors.initials: H
authors.lastname: Koshino
authors.forename: A
authors.initials: A
authors.lastname: Nakagawa
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects; D016169:Lymphocyte Function-Associated Antigen-1 / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D016169:Lymphocyte Function-Associated Antigen-1; D010545:Peroxides; D014966:Xanthenes; C406042:adxanthromycin A; C406043:adxanthromycin B; D018799:Intercellular Adhesion Molecule-1