title: Methadone dose and retention during treatment of heroin addicts with Axis I psychiatric comorbidity.
abstract: We studied 90 opioid-dependent subjects, 38 with one or more additional Axis I diagnosis and 52 with no psychiatric comorbidity. There were significant differences between these two groups regarding the methadone dose required for clinical stabilization, but not in the rate of retention in treatment. Dual Diagnosis patients, those with psychiatric comorbidity, required an average stabilization dose of 154 +/- 84 of methadone compared to 99 +/- 49 mg/day for patients whose only Axis I diagnosis was Opioid Dependence. In the 990-day period considered there were no differences between the two groups of patients in terms of retention in treatment.
authors.affiliation: Department of Psychiatry-Neurobiology-Pharmacology and Biotechnology, University of Pisa, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Maremmani
authors.forename: O
authors.initials: O
authors.lastname: Zolesi
authors.forename: M
authors.initials: M
authors.lastname: Aglietti
authors.forename: G
authors.initials: G
authors.lastname: Marini
authors.forename: A
authors.initials: A
authors.lastname: Tagliamonte
authors.forename: M
authors.initials: M
authors.lastname: Shinderman
authors.forename: S
authors.initials: S
authors.lastname: Maxwell
mesh_terms: D000328:Adult; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006556:Heroin Dependence / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000523:psychology / Q000534:rehabilitation*; D008691:Methadone / Q000008:administration & dosage*; D010349:Patient Compliance / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D008691:Methadone