[The study on the relationship between luteal phase serum sex hormone levels and pregnancy outcome in in vitro fertilization embryo transfer cycle].
OBJECTIVE
To study the influence of maternal endocrine factors on clinical pregnancy outcome in an in Vitro Fertilization Embryo Transfer (IVF-ET) program.


METHODS
62 IVF-ET treatment cylces were studied. Luteal phase serum sex hormone levels [estrogen (E2), progesterone (P), prolactin (PRL)] in natural and superovulation cycles were measured by radioimmunoassay and the clinical pregnancy outcome was observed.


RESULTS
Serum luteal phase sex hormone levels were higher than in natural cycles (P < 0.05). P level and P/E2 ratio in progesterone supplementation group were higher than the group without progesterone supplementation (P < 0.05). In pregnancy group serum E2(4,885.5 +/- 1,269.0 pmol/L) was lower, PRL (66.4 +/- 26.8 micrograms/L), P/E2 (373.0 +/- 152.5) were higher than in nonpregnancy group (E2 6,091.2 +/- 1,522.1 pmol/L, PRL 49.1 +/- 24.1 micrograms/L, P/E2 227.4 +/- 116.7) (P < 0.05). When P/E2 ratio was between 300-400 and PRL level was between 60-100 micrograms/L, the clinical pregnancy rate increased markedly (P < 0.05).


CONCLUSIONS
Luteal phase serum sex hormone level may influence embryo implantation in IVF-ET. In order to improve the clinical pregnancy rate, it is very necessary to supplement progesterone for the IVF-ET patients according to the different sex hormone levels.
Tian
X
X
First Hospital, Shanxi Medical University, Taiyuan.
Zhang
L
L
Yang
C
C
D004624:Embryo Transfer; D004967:Estrogens / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007247:Infertility, Female / Q000097:blood*; D008183:Luteal Phase / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013480:Superovulation / Q000097:blood
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D011374:Progesterone; D011388:Prolactin