title: hedgehog and wing development in Drosophila: a morphogen at work?
abstract: In Drosophila, Hedgehog (Hh) is a key regulator of limb development and activates decapentaplegic (dpp), a gene encoding a TGFbeta-related factor that controls growth and patterning of the limbs. During wing development, Hh also has morphogen-like Dpp-independent functions, controlling the morphogenesis of the central part of the wing through the activation of the evolutionarily conserved transcription factors encoded by the iroquois and collier genes. The ways in which Hh forms an activity gradient to lay the basis of patterning of the adult wing are described here. As the signal transduction pathway of Hh is strongly conserved during evolution and human Hh may be implicated in congenital diseases and cancers, these observations provide important advances which may help in understanding the function of Hh proteins in normal and pathological development and tumourigenesis in humans.
authors.affiliation: Evolution et Développement des Protostomien,Centre de Génétique Moléculaire-UMR 2067 CNRS; 1, avenue de la terrasse, F-91198 Gif-sur-Yvette Cedex, France. vervoort@cgm.cnrs-gif.fr
authors.forename: M
authors.initials: M
authors.lastname: Vervoort
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila / Q000254:growth & development*; D029721:Drosophila Proteins; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009024:Morphogenesis; D020033:Protein Isoforms / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014921:Wings, Animal / Q000254:growth & development*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D020033:Protein Isoforms; D012097:Repressor Proteins; C490764:SUFU protein, human; C097059:Su(fu) protein, Drosophila; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C092937:ci protein, Drosophila; C064196:dpp protein, Drosophila; C104357:kn protein, Drosophila; C077245:hh protein, Drosophila