title: A gene for hypotrichosis simplex of the scalp maps to chromosome 6p21.3.
abstract: Hypotrichosis simplex of the scalp (HSS) is an autosomal dominant form of isolated alopecia causing almost complete loss of scalp hair, with onset in childhood. After exclusion of candidate regions previously associated with hair-loss disorders, we performed a genomewide linkage analysis in two Danish families and localized the gene to chromosome 6p21.3. This was confirmed in a Spanish family, with a total LOD score of 11.97 for marker D6S1701 in all families. The combined haplotype data identify a critical interval of 14.9 cM between markers D6S276 and D6S1607. Localization of the locus for HSS to 6p21.3 is a first step toward identification of the gene. The gene will give important insights into the molecular and cellular basis of hair growth on the scalp.
authors.affiliation: Institute of Human Genetics, University of Bonn, D-53111 Bonn, Germany. r.betz@uni-bonn.de
authors.forename: R C
authors.initials: RC
authors.lastname: Betz
authors.forename: Y A
authors.initials: YA
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Bygum
authors.forename: F
authors.initials: F
authors.lastname: Brandrup
authors.forename: A I
authors.initials: AI
authors.lastname: Bernal
authors.forename: J
authors.initials: J
authors.lastname: Toribio
authors.forename: J I
authors.initials: JI
authors.lastname: Alvarez
authors.forename: G M
authors.initials: GM
authors.lastname: Kukuk
authors.forename: H H
authors.initials: HH
authors.lastname: Ibsen
authors.forename: H B
authors.initials: HB
authors.lastname: Rasmussen
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
authors.forename: A
authors.initials: A
authors.lastname: Reis
authors.forename: P
authors.initials: P
authors.lastname: Propping
authors.forename: R
authors.initials: R
authors.lastname: Kruse
authors.forename: S
authors.initials: S
authors.lastname: Cichon
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D006197:Hair / Q000503:physiopathology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007039:Hypotrichosis / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009426:Netherlands; D010375:Pedigree; D015203:Reproducibility of Results; D012535:Scalp / Q000503:physiopathology*; D013030:Spain