Evidence for infection with Chlamydia pneumoniae in a subgroup of patients with multiple sclerosis.
In a pilot study, we identified Chlamydia pneumoniae in the cerebrospinal fluid by polymerase chain reaction in 5 of 10 patients with definite multiple sclerosis (MS). In a second series, 2 of 20 patients with definite MS and 3 of 17 patients with possible/probable MS or MS variants, but none of 56 patients with other neurological, diseases were polymerase chain reaction-positive. We confirm that C. pneumoniae can be found in the cerebrospinal fluid of MS patients, but our rate of positive results is lower than in a recent report.
Layh-Schmitt
G
G
Department of Microbiology, University of Heidelberg, Germany.
Bendl
C
C
Hildt
U
U
Dong-Si
T
T
Jüttler
E
E
Schnitzler
P
P
Grond-Ginsbach
C
C
Grau
A J
AJ
D000293:Adolescent; D000328:Adult; D002690:Chlamydia Infections / Q000134:cerebrospinal fluid / Q000150:complications* / Q000175:diagnosis; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D004269:DNA, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000382:microbiology; D009187:Myelitis / Q000134:cerebrospinal fluid / Q000382:microbiology; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid / Q000382:microbiology; D010865:Pilot Projects; D016133:Polymerase Chain Reaction
D004269:DNA, Bacterial