Comparative effects of alpha-receptor stimulation and nitrergic inhibition on bronchovascular tone.
Adrenergic agonists are known to influence bronchial blood flow and bronchovascular resistance. Recently, the nitrergic system has also been implicated in the control of bronchovascular tone. In this study, we compared the effects of the nitric oxide synthase inhibitor N(omega)-nitro-L-arginine methyl ester (L-NAME) and the alpha(1)-receptor agonist phenylephrine on bronchovascular resistance in anesthetized sheep (n = 9). Bronchial blood flow, cardiac output, and systemic and pulmonary arterial pressures were continuously monitored. Phenylephrine (1.2-3.4 microg. kg(-1). min(-1)) was infused intravenously to increase mean systemic arterial pressure above 95 Torr for 10 min and then was discontinued. When hemodynamic parameters returned to baseline, nebulized phenylephrine (10 mg) was given over 10 min. When parameters again normalized, L-NAME (30 mg/kg) was infused intravenously over 1 min. Intravenous phenylephrine increased systemic vascular resistance by 40% at 10 min with no concurrent increase in bronchovascular resistance, but inhaled phenylephrine increased bronchovascular resistance by 66% at 10 min. By comparison, intravenous L-NAME produced a rapid and sustained fivefold increase in bronchovascular resistance at 10 min. We conclude that, although alpha-agonist stimulation has some influence on bronchovascular resistance in sheep, the nitrergic system has predominant control of bronchovascular tone.
Carvalho
P
P
Pulmonary Research Laboratory, Department of Veterans Affairs Medical Center, Boise, Idaho 83702, USA.
Thompson
W H
WH
Charan
N B
NB
D000280:Administration, Inhalation; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000818:Animals; D001980:Bronchi / Q000098:blood supply*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007275:Injections, Intravenous; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D010656:Phenylephrine / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D012756:Sheep; D014666:Vasomotor System / Q000187:drug effects / Q000502:physiology*
D000316:Adrenergic alpha-Agonists; D004791:Enzyme Inhibitors; D011942:Receptors, Adrenergic, alpha; D010656:Phenylephrine; D009569:Nitric Oxide; D019331:NG-Nitroarginine Methyl Ester