Resting metabolic rate, body composition, and serum leptin concentrations in a free-living elderly population.
OBJECTIVE
The present study investigated the relationship between serum leptin concentrations and resting metabolic rate (RMR) in a large study group of elderly individuals with special consideration of body composition and body fat distribution as possible confounders.


METHODS
The subjects were 122 women (age: 69+/-6 years, body mass index (BMI): 26.3+/-3.6 kg/m(2)) and 82 men (age: 69+/-5 years, BMI: 26.0+/-2.6 kg/m(2)). RMR was measured by indirect calorimetry and body composition by the bioelectrical impedance method. Serum leptin levels were determined by radioimmunoassay.


RESULTS
There was a strong correlation between fat mass (FM) and serum leptin levels in both sexes. An age-related decline in leptin levels adjusted for FM was observed only in the women. After adjustment of RMR for both fat-free mass (FFM) and FM, leptin levels were not associated with RMR. In stepwise multiple regression analysis, FFM was the main predictor of RMR, explaining 35.8% and 47.6% of the variance of RMR in men and women respectively. FM did not explain variance in RMR in men, but accounted for 2.6% of the variance in RMR in women. Waist-hip-ratio and age influenced RMR only in males, explaining 5.7% and 4.0% of the variance in RMR respectively.


CONCLUSIONS
Leptin is not a significant predictor of RMR in the elderly, but body composition and distribution of body fat are significantly associated with RMR.
Neuhäuser-Berthold
M
M
Institute of Nutritional Sciences, Justus-Liebig-University, Giessen, Germany. Monika.Neuhaeuser-Berthold@ernaehrung.uni-giessen.de
Herbert
B M
BM
Lührmann
P M
PM
Sültemeier
A A
AA
Blum
W F
WF
Frey
J
J
Hebebrand
J
J
D000367:Age Factors; D000368:Aged; D001481:Basal Metabolism; D001823:Body Composition; D001824:Body Constitution; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D011159:Population Surveillance; D012044:Regression Analysis; D012111:Residence Characteristics
D020738:Leptin