title: Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease.
abstract: Two genetic markers of the plasma protein alpha2-macroglobulin, a 5 bp deletion/insertion at the 5' splice site of exon 18 (A2MI) and the GTC/ATC (VaIIO00IIe) in exon 24 (A2M2), may have roles in the development of Alzheimer's disease (AD). Genotyping and linkage analysis of these markers in 426 Japanese sporadic AD patients, 85 autopsy-confirmed Caucasian AD cases, and, as controls, 382 Japanese and 65 Caucasians who were cognitively normal and 140 Japanese Parkinson's disease patients showed racial diversity in the frequencies and relationship of the two markers. Comparison of genotype and allele frequencies, stratification of the samples by the presence of the apolipoprotein E epsilon4 allele, and logistic regression analysis revealed no association of these markers with AD in either racial group.
authors.affiliation: Division of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka Kanagawa, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: S
authors.initials: S
authors.lastname: Matsushita
authors.forename: J
authors.initials: J
authors.lastname: Nakane
authors.forename: H
authors.initials: H
authors.lastname: Arai
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Urakami
authors.forename: T
authors.initials: T
authors.lastname: Yuzuriha
authors.forename: A
authors.initials: A
authors.lastname: Takeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D010300:Parkinson Disease / Q000235:genetics; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D044465:White People / Q000235:genetics*; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D005819:Genetic Markers; D000511:alpha-Macroglobulins