Polynucleotides. XXIV. Synthesis and properties of a dinucleoside monophosphate derived from uridine 6,2-cyclonucleoside.
A dinucleoside monophosphate, 6,2'-anhydro-6-oxy-1-beta-D-arabinofuranosyluracil-phosphoryl- (3'-5')-6,2'-anhydro-6-oxy-1-beta-D-arabinofuranosyluracil (I) was synthesized by the condensation reaction using DCC from 5'-monomethoxytrityl derivative(VII) and 3'-acetyl-5'-phosphate(X) of the monomer units. Yield was ca. 70%. UV of compound I showed no hypochromicity and its CD spectrum showed only a trough at 252 nm. No temperature dependency of epsilon and [Q] values was observed. These results suggested an unstacked random conformation for I. Complex formation of I with cycloadenosine oligomer could not be detected under the experimental condition.
Ikehara
M
M
Tezuka
T
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D000227:Adenine Nucleotides / Q000737:chemistry; D002942:Circular Dichroism; D015226:Dinucleoside Phosphates / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis; D009690:Nucleic Acid Conformation; D009843:Oligoribonucleotides / Q000737:chemistry; D011061:Poly A / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D014529:Uridine / Q000031:analogs & derivatives / Q000737:chemistry
C407764:6,2'-anhydro-6-oxy-1-arabinofuranosyluracil-phosphoryl-(3'-5')- 6,2'-anhydro-6-oxy-1-arabinofuranosyluracil; D000227:Adenine Nucleotides; D015226:Dinucleoside Phosphates; D009843:Oligoribonucleotides; D011061:Poly A; C023505:2',5'-oligoadenylate; D014529:Uridine