Parallel Synthesis of Alkyl Tetrazole Derivatives Using Solid Support Chemistry.
The synthesis of several omega-chloroalkyl tetrazoles and their subsequent attachment to a solid support is described. Using an in situ Finkelstein reaction, a variety of nucleophiles were alkylated and then cleaved from the resin to give pure alkyl tetrazole derivatives. A sample library of 5 x 6 demonstrates the general utility of this sequence.
Matthews
DP
Discovery Chemistry Research, Eli Lilly and Company, Indianapolis, Indiana 46285, DePauw University, Greencastle, Indiana, and Parker H. Petit Institute for Bioengineering and Biosciences, Atlanta, Georgia.
Green
JE
Shuker
AJ