title: Organization and expression of calicivirus genes.
abstract: The application of molecular techniques to the characterization of caliciviruses has resulted in an extensive database of sequence information. This information has led to the identification of 4 distinct genera. The human enteric caliciviruses have been assigned to 2 of these genera. This division is reflected not only in sequence diversity but in a fundamental difference in genome organization. Complete genome sequences are now available for 5 enteric caliciviruses and demonstrate that human and animal enteric caliciviruses are phylogenetically closely related. Currently, there is no cell culture system for the human viruses; therefore, studies have relied on heterologous expression and in vitro systems. These studies have shown that in both human and animal viruses the viral nonstructural proteins are produced from a polyprotein precursor that is cleaved by a single viral protease. The purpose of this article is to provide an overview of the current knowledge of genome structure and gene expression in the enteric caliciviruses.
authors.affiliation: Virology Group, University Medical School, Southampton General Hospital, Southampton, SO16 6YD, UK. inc@soton.ac.uk.
authors.forename: I N
authors.initials: IN
authors.lastname: Clarke
authors.forename: P R
authors.initials: PR
authors.lastname: Lambden
mesh_terms: D000818:Animals; D002139:Caliciviridae / Q000235:genetics*; D002213:Capsid / Q000378:metabolism; D015870:Gene Expression; D016679:Genome, Viral; D006801:Humans; D009663:Norwalk virus / Q000235:genetics*; D014764:Viral Proteins / Q000378:metabolism
chemical_list: D014764:Viral Proteins