title: Soy protein isolate and its hydrolysate reduce body fat of dietary obese rats and genetically obese mice (yellow KK)
abstract: This study examined in dietary obese and genetically obese rodents the effects of soy protein isolate (SPI) and its hydrolysate (SPI-H) on the rate of body-fat disappearance. Male Sprague-Dawley rats (4-16 wk old) and yellow KK mice (6-10 wk old) were made obese by feeding high-fat diets containing 30% fat. They were then fed energy-restricted, low-fat (5.0%), and high-protein (35% casein, SPI, or SPI-H) diets for 4 wk at 60% of the level of the energy intake of rodents on laboratory chow. The body-fat contents of rats and mice fed a high-fat diet were 27.3 and 33.6 g/100 g body weight, respectively, at the end of the obese period. For rats, the apparent absorbability of dietary energy and fat was significantly lower in the SPI and SPI-H groups than in the casein group, but vice-versa for nitrogen balance. Body-fat content in mice fed SPI and SPI-H diets was significantly lower than in those fed the casein diet. In rats, plasma total cholesterol level was lower with the SPI-H diet, and plasma glucose level was lower with the SPI and SPI-H diets than with the casein diet. These results indicate that SPI and SPI-H are suitable protein sources in energy-restricted diets for the treatment of obesity.
authors.affiliation: Department of Novelty Materials, Research Institute, Fuji Oil Co., Ltd., Izumisano, Osaka, Japan. aoyama@hkc.fujioil.co.jp
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.forename: K
authors.initials: K
authors.lastname: Fukui
authors.forename: K
authors.initials: K
authors.lastname: Takamatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000187:drug effects; D002364:Caseins / Q000008:administration & dosage; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009584:Nitrogen / Q000378:metabolism; D009765:Obesity / Q000178:diet therapy* / Q000517:prevention & control; D011492:Protein Hydrolysates / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D030262:Soybean Proteins / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D013047:Specific Pathogen-Free Organisms; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D001786:Blood Glucose; D002364:Caseins; D004041:Dietary Fats; D011492:Protein Hydrolysates; D030262:Soybean Proteins; D014280:Triglycerides; D002784:Cholesterol; D009584:Nitrogen