title: General anesthesia mode does not influence endocrine or immunologic profile after open or laparoscopic cholecystectomy.
abstract: To verify the impact on stress response and the influence of anesthesia on endocrine/immunologic changes, we have investigated the plasma level of norepinephrine, cortisol, TNFalpha, and IL-6 in 46 patients scheduled for laparotomy and laparoscopic cholecystectomy at 2, 6, 12, and 24 h after the operation. Among subjects who underwent open approach, 9 received fentanyl anesthesia and 13 received isoflurane anesthesia. In the laparoscopy group, 14 patients were given fentanyl anesthesia and 10 were given isoflurane anesthesia. The results obtained confirmed that laparoscopic cholecystectomy is associated with a lesser immunoendocrine response, and the two anesthesia models do not interfere with plasma changes of the assessed hormones and cytokines.
authors.affiliation: Institute of Anesthesia and Intensive Care, La Sapienza University, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Delogu
authors.forename: G
authors.initials: G
authors.lastname: Famularo
authors.forename: S
authors.initials: S
authors.lastname: Luzzi
authors.forename: P
authors.initials: P
authors.lastname: Rubcich
authors.forename: A
authors.initials: A
authors.lastname: Giardina
authors.forename: R
authors.initials: R
authors.lastname: Masciangelo
authors.forename: A
authors.initials: A
authors.lastname: Antonucci
authors.forename: L
authors.initials: L
authors.lastname: Signore
mesh_terms: D000768:Anesthesia, General; D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D005283:Fentanyl; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007530:Isoflurane; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D013312:Stress, Physiological / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D007530:Isoflurane; D005283:Fentanyl; D006854:Hydrocortisone; D009638:Norepinephrine