title: Role of acetylcholine in regulation of interaction between axon and Schwann cell during rhythmic excitation of nerve fibers.
abstract: Axon excitation increases the number of acetylcholine receptors (ACR) of the Schwann cell (SC) depending on the frequency of rhythmic excitation (RE) and on intercellular concentrations of K+, Ca2+, and acetylcholine. During RE, activity of axonal acetylcholine esterase is decreased, thus providing for high intercellular acetylcholine concentration. Increased intercellular concentration of acetylcholine activates phosphoinositide-specific phospholipase C (PIPLC) of the myelin nerve fiber. During RE, K+ depolarization and acetylcholine exocytosis can activate Ca2+ entry via Ca2+ channels, thus inducing SC ACR phosphorylation mediated by PIPLC stimulation.
authors.affiliation: School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia. maxim@biophys.msu.ru
authors.forename: G V
authors.initials: GV
authors.lastname: Maximov
authors.forename: V V
authors.initials: VV
authors.lastname: Revin
authors.forename: I P
authors.initials: IP
authors.lastname: Grunyushkin
authors.forename: O R
authors.initials: OR
authors.lastname: Kols
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001001:Anura; D001253:Astrocytes / Q000378:metabolism; D001369:Axons / Q000378:metabolism* / Q000502:physiology; D003386:Brachyura; D002118:Calcium / Q000502:physiology; D002450:Cell Communication; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D007477:Ions; D009412:Nerve Fibers / Q000378:metabolism*; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D011188:Potassium / Q000502:physiology; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism* / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
chemical_list: D007477:Ions; D011950:Receptors, Cholinergic; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium