title: Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.
abstract: [reaction: see text] Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated. This pathway illustrates a key element in a planning algorithm for diversity-oriented synthesis. This element facilitates the efficient synthesis of structurally complex compounds, and it can be integrated with ones that provide structurally diverse compounds.
authors.affiliation: Howard Hughes Medical Institute, Department of Chemistry & Chemical Biology, Harvard Institute of Chemistry & Cell Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: J K
authors.initials: JK
authors.lastname: Sello
authors.forename: S L
authors.initials: SL
authors.lastname: Schreiber
mesh_terms: D015394:Molecular Structure; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009930:Organic Chemicals