Folate sufficient subjects do not accumulate additional folates during supplementation.
In a double-blinded placebo-controlled trial of folic acid supplementation in 82 alcoholic subjects, it was found that whole blood folate levels, determined by a mass spectrometric method, do not increase in subjects whose baseline folate levels are above the third quartile (folate sufficiency). Since a state of folate sufficiency can now be identified, a recommended daily allowance (RDA) for folate can be determined using objective means.
Santhosh-Kumar
C R
CR
Department of Medicine, Royal Hospital, Muscat, Oman.
Bisping
J S
JS
Kick
S D
SD
Deutsch
J C
JC
Kolhouse
J F
JF
D000284:Administration, Oral; D000328:Adult; D000437:Alcoholism; D004311:Double-Blind Method; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage* / Q000097:blood*; D005494:Folic Acid Deficiency / Q000097:blood / Q000188:drug therapy*; D006397:Hematinics / Q000008:administration & dosage* / Q000097:blood*; D006801:Humans; D008297:Male
D006397:Hematinics; D005492:Folic Acid