title: A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.
abstract: The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.
authors.affiliation: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
authors.forename: Y T
authors.initials: YT
authors.lastname: Jung
authors.forename: C A
authors.initials: CA
authors.lastname: Kozak
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D002213:Capsid / Q000235:genetics*; D002460:Cell Line; D005622:Friend murine leukemia virus / Q000235:genetics* / Q000472:pathogenicity*; D051379:Mice; D008969:Molecular Sequence Data; D010641:Phenotype