Dental manifestations in severe combined immunodeficiency following bone marrow transplantation.
Severe combined immunodeficiency (SCID) is a rare primary immunodeficiency disorder with an estimated overall frequency of 1 in 75 000 live births. Bone marrow transplantation is the only curative treatment available. Using T cell-depleted HLA non-identical bone marrow requires preconditioning with a short course of cytotoxic chemotherapy. We report severe dental developmental anomalies in three such patients under long-term follow up.
Cole
B O
BO
Dept of Child Dental Health, Dental Hospital and School, Newcastle upon Tyne, UK.
Welbury
R R
RR
Bond
E
E
Abinun
M
M
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D006801:Humans; D007223:Infant; D008212:Lymphocyte Depletion; D008297:Male; D016511:Severe Combined Immunodeficiency / Q000503:physiopathology* / Q000628:therapy*; D013997:Time Factors; D014071:Tooth Abnormalities / Q000209:etiology*