title: The effect of varying substituents on the equilibrium distribution and conformation of macrocyclic steroidal N-acyl hydrazones
abstract: The equilibrium distribution of deoxycholate-based macrocyclic N-acyl hydrazones is dependent upon the nature of the substituents at the 3- and 12-position. These substituents can also influence the preferred conformation of the macrocycles. The conversion of pure cyclic dimer and trimer into a mixture of both components, in the presence of trifluoroacetic acid, has been demonstrated and an X-ray crystal structure obtained of a macrocyclic N-acyl hydrazone dimer.
authors.affiliation: University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, U.K.
authors.initials: MG
authors.lastname: Simpson
authors.initials: SP
authors.lastname: Watson
authors.initials: N
authors.lastname: Feeder
authors.initials: JE
authors.lastname: Davies
authors.initials: JK
authors.lastname: Sanders