title: Role of B cells in maintaining helper T-cell memory.
abstract: The cellular interactions involved in maintaining CD4+ T-cell memory have hitherto not been identified. In this report, we have investigated the role played by B cells in this process. We show that that long-lasting helper T-cell memory depends on the presence of B cells, but that direct antigen presentation by B cells is not required. These findings provide new insights into the mechanisms which underlie helper T-cell memory. They also suggest that the efficacy of future vaccines will depend critically on the inclusion of B- as well as T-cell epitopes.
authors.affiliation: Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK.
authors.forename: D
authors.initials: D
authors.lastname: van Essen
authors.forename: P
authors.initials: P
authors.lastname: Dullforce
authors.forename: D
authors.initials: D
authors.lastname: Gray
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006183:H-2 Antigens / Q000276:immunology; D006433:Hemocyanins / Q000276:immunology; D064532:Histocompatibility Antigen H-2D; D007156:Immunologic Memory / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016513:Mice, SCID; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D064532:Histocompatibility Antigen H-2D; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin