title: CTLA4 exon 1 dimorphism in bullous and cicatricial pemphigoid.
abstract: The human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene encodes proteins regulating the immune response. The polymorphism of this gene is associated with some autoimmune diseases. In this study, we analysed the distribution of the dimorphisms of exon 1 (+ 49 A/G) in bullous pemphigoid (BP) and cicatricial pemphigoid (CP), two types of autoimmune bullous skin diseases that occur in elderly people. The frequency of the exon 1 A-G genotype was marginally decreased in patients (36.4%; n = 55) compared with controls (52.8%, n = 53), but the results were not statistically significant (P = 0.09).
authors.affiliation: Immunology Laboratory, Limoges, France.
authors.forename: M
authors.initials: M
authors.lastname: Drouet
authors.forename: C
authors.initials: C
authors.lastname: Aupetit
authors.forename: N
authors.initials: N
authors.lastname: Delpuget-Bertin
authors.forename: C
authors.initials: C
authors.lastname: Bedane
authors.forename: J M
authors.initials: JM
authors.lastname: Bonnetblanc
authors.forename: M
authors.initials: M
authors.lastname: Cogné
mesh_terms: D000069594:Abatacept; D000483:Alleles; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics*; D060908:CTLA-4 Antigen; D006801:Humans; D018796:Immunoconjugates; D010390:Pemphigoid, Benign Mucous Membrane / Q000235:genetics*; D011110:Polymorphism, Genetic; D012872:Skin Diseases, Vesiculobullous / Q000235:genetics*
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D000069594:Abatacept