title: Magnesium sulfate for treating exacerbations of acute asthma in the emergency department.
abstract: BACKGROUND
  Treatment of acute asthma is based on rapid reversal of bronchospasm and arresting airway inflammation. There is some evidence that intravenous magnesium can provide additional bronchodilation when given in conjunction with standard bronchodilating agents and corticosteroids. No systematic review of this literature has been completed on this topic.
  
  
  OBJECTIVE
  To examine the effect of additional intravenous magnesium sulfate in patients with acute asthma managed in the emergency department.
  
  
  METHODS
  Randomised controlled trials were identified from the Cochrane Airways Review Group register. Bibliographies from included studies, known reviews and texts were searched. Primary authors and content experts were contacted.
  
  
  METHODS
  Randomised controlled trials or quasi-randomised trials were eligible for inclusion. Studies were included if patients presented with acute asthma and were treated with IV magnesium sulfate vs placebo.
  
  
  METHODS
  Data were extracted and methodological quality was assessed independently by two reviewers. Missing data were obtained from authors.
  
  
  RESULTS
  Seven trials were included (5 adult, 2 pediatric). A total of 665 patients were involved. Patients receiving magnesium sulfate demonstrated non-significant improvements in peak expiratory flow rates when all studies were pooled (weighted mean difference: 29.4 L/min; 95% confidence interval: -3.4 to 62). In studies of people with severe acute asthma, peak expiratory flow rate improved by 52.3 L/min (95% confidence interval: 27 to 77.5). The forced expiratory volume in one second also improved by 9.8 % predicted (95% confidence interval: 3.8 to 15.8). Overall, admission to hospital was not reduced, odds ratio: 0.31 (95% confidence interval: 0.09 to 1.02). In the severe subgroup, admissions were reduced in those receiving magnesium sulfate (odds ratio: 0.10, 95% confidence interval: 0.04 to 0.27). No clinically important changes in vital signs or adverse side effects were reported.
  
  
  CONCLUSIONS
  Current evidence does not support routine use of intravenous magnesium sulfate in all patients with acute asthma presenting to the emergency department. Magnesium sulfate appears to be safe and beneficial in patients who present with severe acute asthma.
authors.affiliation: Division of Emergency Medicine, University of Alberta, 1G1 Walter Mackenzie Centre, 8440-112 Street, Edmonton, Alberta, Canada, T6G 2B7. Brian.Rowe@gpu.srv.ualberta.ca
authors.forename: B H
authors.initials: BH
authors.lastname: Rowe
authors.forename: J A
authors.initials: JA
authors.lastname: Bretzlaff
authors.forename: C
authors.initials: C
authors.lastname: Bourdon
authors.forename: G W
authors.initials: GW
authors.lastname: Bota
authors.forename: C A
authors.initials: CA
authors.lastname: Camargo
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D004359:Drug Therapy, Combination; D004636:Emergency Service, Hospital; D006801:Humans; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D001993:Bronchodilator Agents; D008278:Magnesium Sulfate