beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
beta-catenin mutations have been found not only in melanoma and prostatic carcinoma but also in hepatocellular carcinomas in human, c-myc, H-ras genes transgenic mice and chemically-induced models. We investigated beta-catenin mutations in human hepatocellular carcinomas (HCCs), Hep G2 cell line and HCCs in SV40 T-antigen transgenic mice, in order to examine whether beta-catenin mutations are frequently observed in HCC in general. We found a point mutation of beta-catenin in one of nine HCCs in human and a deletion of it in Hep G2 cell line. However, we found no mutation in HCC in SV40 TG mice liver.
Umeda
T
T
Department of Experimental Pathology, Cancer Institute, Tokyo, Japan.
Yamamoto
T
T
Kajino
K
K
Hino
O
O
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D017354:Point Mutation / Q000235:genetics*; D015534:Trans-Activators; D014407:Tumor Cells, Cultured; D051176:beta Catenin
D000952:Antigens, Polyomavirus Transforming; C495270:CTNNB1 protein, human; C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin