title: Ultrasound thrombolysis for the treatment of thrombotic occlusion of degenerated saphenous vein grafts.
abstract: Despite improvements in catheter-based revascularization outcomes, coronary interventionalists face difficult challenges in the treatment of the thrombus-laden coronary lesion. In this report, we describe the use of the Acolysis device, which utilizes high-frequency (41.9 kHz) ultrasonic energy to vibrate a small metal tip at the end of a 4.5 Fr catheter to treat two thrombotically occluded saphenous vein grafts in two patients. In both cases, the Acolysis device provided normalization of flow with angiographically evident dissolution of thrombus and excellent acute angiographic and clinical results. We conclude that in these two selected cases the Acolysis device was used safely and effectively for thrombus debulking as an adjunct to stenting in diseased saphenous vein bypass grafts.
authors.affiliation: Heart Institute at Borgess Medical Center, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan, USA. taf1@net-link.net
authors.forename: T A
authors.initials: TA
authors.lastname: Fischell
authors.forename: N
authors.initials: N
authors.lastname: Haddad
authors.forename: S
authors.initials: S
authors.lastname: Baskerville
authors.forename: M T
authors.initials: MT
authors.lastname: Foster
mesh_terms: D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000628:therapy*; D006085:Graft Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D012501:Saphenous Vein / Q000473:pathology* / Q000637:transplantation; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000628:therapy*; D016896:Treatment Outcome; D014464:Ultrasonic Therapy