title: Variability of relative blood volume during haemodialysis.
abstract: BACKGROUND
  A decrease in blood volume is thought to play a role in dialysis-related hypotension. Changes in relative blood volume (RBV) can be assessed by means of continuous haematocrit measurement. We studied the variability of RBV changes, and the relation between RBV and ultrafiltration volume (UV), blood pressure, heart rate, and inferior caval vein (ICV) diameter.
  
  
  METHODS
  In 10 patients on chronic haemodialysis, RBV measurement was performed during a total of one hundred 4-h haemodialysis sessions. Blood pressure and heart rate were measured at 5-min intervals. ICV diameter was assessed at the start and at the end of dialysis using ultrasonography.
  
  
  RESULTS
  The changes in RBV showed considerable inter-individual variability. The average change in RBV ranged from -0.5 to -8.2% at 60 min and from -3.7 to -14.5% at 240 min (coefficient of variation (CV) 0.66 and 0.35 respectively). Intra-individual variability was also high (CV at 60 min 0.93; CV at 240 min 0.33). Inter-individual as well as intra-individual variability showed only minor improvement when RBV was corrected for UV. We found a significant correlation between RBV and UV at 60 (r= -0.69; P<0.001) and at 240 min (r= -0.63; P<0.001). There was a significant correlation between RBV and heart rate (r= -0.39; P<0.001), but not between RBV or UV and blood pressure. The level of RBV reduction at which hypotension occurred was also highly variable. ICV diameter decreased from 10.3+/-1.7 mm/m(2) to 7.3+/-1. 5 mm/m(2). There was only a slight, although significant, correlation between ICV diameter and RBV (r= -0.23; P<0.05). The change in ICV-diameter showed a wide variation.
  
  
  CONCLUSIONS
  RBV changes during haemodialysis showed a considerable intra- and inter-individual variability that could not be explained by differences in UV. No correlation was observed between UV or changes in RBV and either blood pressure or the incidence of hypotension. Heart rate, however, was significantly correlated with RBV. Moreover, IVC diameter was only poorly correlated with RBV, suggesting a redistribution of blood towards the central venous compartment. These data indicate that RBV monitoring is of limited use in the prevention of dialysis-related hypotension, and that the critical level of reduction in RBV at which hypotension occurs depends on cardiovascular defence mechanisms such as sympathetic drive.
authors.affiliation: Department of Internal Medicine I, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands.
authors.forename: H P
authors.initials: HP
authors.lastname: Krepel
authors.forename: R W
authors.initials: RW
authors.lastname: Nette
authors.forename: E
authors.initials: E
authors.lastname: Akçahüseyin
authors.forename: W
authors.initials: W
authors.lastname: Weimar
authors.forename: R
authors.initials: R
authors.lastname: Zietse
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001810:Blood Volume; D005260:Female; D006400:Hematocrit; D006440:Hemofiltration; D006801:Humans; D007022:Hypotension / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D006435:Renal Dialysis / Q000009:adverse effects; D014463:Ultrasonography; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging