[The laboratory diagnosis of cytomegalovirus infection in infants in the first months of life].
The detection rate of IgM, specific to cytomegalovirus (CMV), in the umbilical blood was 2.0 +/- 1.8% in infants with antenatal complications in their medical history, 8.9 +/- 1.8% in hospitalized infants aged 7 days to 6 months; simultaneously, such IgM proved to be absent in healthy infants of the same age. The maximum primary detection rate of CMV-specific IgM in hospitalized infants was registered at the age of 1.5-4 months and the minimum detection rate, at the age of 6 months, as well as at the age of 1 month and younger. In sick infants aged 0-6 months CMV-specific IgM were detected, as a rule, for 2-4 weeks. 86% of infants with CMV-specific IgM detected in their blood were found to have cytomegaloviremia; in 80% of patients the virus was excreted with saliva and in 50% the virus was detected in blood plasma.
Kochengina
S A
SA
State Medical Academy, Chelyabinsk, Russia.
Teplova
S N
SN
Rusanova
N N
NN
Malinovskaia
V V
VV
Posevaia
T A
TA
D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007372:Interferons / Q000097:blood
D000914:Antibodies, Viral; D007136:Immunoglobulins; D007372:Interferons