Identification and role of aldosterone receptors in the cardiovascular system.
The cardiovascular system is now recognized as an important mineralocorticoid target. All -components required for specific and selective aldosterone effects are present in the cardiovascular system. Mineralocorticoid receptors (MR) are expressed in the heart and large blood vessels together with the 11 B-hydroxysteroid dehydrogenase type II, which ensures the enzymatic protection of MR against glucocorticoids. The recent description of local vascular and cardiac aldosterone biosynthesis strongly supports an autocrine/paracrine hormonal action. Establishment of transgenic mice models of targeted overexpression of the mineralocorticoid receptor should facilitate new insights into the molecular and cellular mechanisms of aldo-sterone actions in the cardiovascular system.
Lombès
M
M
INSERM U 478, IFR02, Faculté de Médécine Xavier Bichat, 16, rue Henri Huchard, 75870 Paris Cedex 18, France.
Farman
N
N
Bonvalet
J P
JP
Zennaro
M C
MC
D000450:Aldosterone / Q000096:biosynthesis / Q000494:pharmacology; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects / Q000503:physiopathology; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D018161:Receptors, Mineralocorticoid / Q000032:analysis* / Q000235:genetics / Q000502:physiology*
D018161:Receptors, Mineralocorticoid; D000450:Aldosterone