Inactivation of viruses by aziridines.
Ethyleneimine (EI) and N-acetylethyleneimine (AEI) have been shown to inactivate viruses belonging to most of the families described by the International Committee for the Taxonomy of Viruses. The mechanism by which they inactivate the viruses has not been established. In this paper, experiments with foot-and-mouth disease virus (FMDV) and poliovirus are described which indicate that the inactivating lesion is on the RNA.
Burrage
T
T
USDA, ARS, Plum Island Animal Disease Center, Greenport, NY 11944, USA.
Kramer
E
E
Brown
F
F
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D005537:Aphthovirus / Q000187:drug effects* / Q000235:genetics; D001388:Aziridines / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D006224:Cricetinae; D006801:Humans; D017955:Poliovirus / Q000187:drug effects* / Q000235:genetics / Q000648:ultrastructure; D014709:Vero Cells
D000998:Antiviral Agents; D001388:Aziridines