title: Characterization of a Mycobacterium smegmatis mutant that is simultaneously resistant to D-cycloserine and vancomycin.
abstract: A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.
authors.affiliation: Department of Microbiology and Molecular Genetics, UMDNJ/New Jersey Medical School, Newark, New Jersey 07103-2714, USA.
authors.forename: M
authors.initials: M
authors.lastname: Peteroy
authors.forename: A
authors.initials: A
authors.lastname: Severin
authors.forename: F
authors.initials: F
authors.lastname: Zhao
authors.forename: D
authors.initials: D
authors.lastname: Rosner
authors.forename: U
authors.initials: U
authors.lastname: Lopatin
authors.forename: H
authors.initials: H
authors.lastname: Scherman
authors.forename: A
authors.initials: A
authors.lastname: Belanger
authors.forename: B
authors.initials: B
authors.lastname: Harvey
authors.forename: G F
authors.initials: GF
authors.lastname: Hatfull
authors.forename: P J
authors.initials: PJ
authors.lastname: Brennan
authors.forename: N D
authors.initials: ND
authors.lastname: Connell
mesh_terms: D000595:Amino Acid Sequence; D003523:Cycloserine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D008969:Molecular Sequence Data; D009154:Mutation; D020102:Mycobacterium smegmatis / Q000187:drug effects / Q000235:genetics*; D016415:Sequence Alignment; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
chemical_list: D014640:Vancomycin; D003523:Cycloserine