title: Photodynamic therapy for residual neoplasms of the perianal skin.
abstract: OBJECTIVE
  The aim of this study was to evaluate the efficacy of photodynamic therapy in the management of residual neoplasms of the perianal skin.
  
  
  METHODS
  This is a retrospective review. Five patients with pathologic confirmation of residual perianal neoplasms were treated with photodynamic therapy. There were three females. The mean age was 52 (range, 33-79) years. Pathology consisted of Bowen's disease in two patients, squamous-cell carcinoma in two patients, and extramammary Paget's disease in one patient. Four patients received one photodynamic therapy treatment and one patient received two treatments three months apart.
  
  
  RESULTS
  Treatment was followed by immediate perianal erythema, subsequent blister formation in 36 to 48 hours, and sloughing of the treated area in 72 hours. With a mean follow-up of 5.2 (range, 1-8) years, there were two recurrences. One recurrence was in a patient four years after treatment for Paget's disease, and the other was in a patient nine months after treatment for Bowen's disease. The latter was managed successfully with wide local excision. Treatment-related toxicities included significant perianal pain in four patients, controlled with analgesia management.
  
  
  CONCLUSIONS
  Photodynamic therapy can successfully be used after wide local excision for residual neoplasms of the perianal skin. Treatment can be rendered with acceptable morbidity.
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, State University of New York at Buffalo, 14263, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Runfola
authors.forename: T K
authors.initials: TK
authors.lastname: Weber
authors.forename: M A
authors.initials: MA
authors.lastname: Rodriguez-Bigas
authors.forename: T J
authors.initials: TJ
authors.lastname: Dougherty
authors.forename: N J
authors.initials: NJ
authors.lastname: Petrelli
mesh_terms: D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000473:pathology*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D010145:Paget Disease, Extramammary / Q000188:drug therapy* / Q000473:pathology; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome