title: Synthesis of two naphthoquinone antibiotics, dehydroherbarin and 6-deoxybostrycoidin.
abstract: The synthesis of two naphthoquinone antibiotics, dehydroherbarin (7) and 6-deoxybostrycoidin (5), was accomplished by reaction of 3-acetonyl-2-bromomethyl-6,8-dimethoxy-1,4-naphthoquinone (23) with either triethylamine or ammonia, respectively. This is the first report on their synthesis.
authors.affiliation: Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, University of Gent, Coupure Links 653, B-9000 Gent, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Kesteleyn
authors.forename: N
authors.initials: N
authors.lastname: De Kimpe
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis*; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D007546:Isoquinolines; D009285:Naphthoquinones; C001334:herbarin; C060461:bostrycoidin