Linkage analysis of chromosome 2q in osteoarthritis.
BACKGROUND
In independent linkage studies chromosome 2q11-q24 and chromosome 2q23-35 have previously been implicated as regions potentially harbouring susceptibility loci for osteoarthritis (OA).


OBJECTIVE
To test chromosome 2q for linkage to idiopathic osteoarthritis.


METHODS
Using a cohort of 481 OA families that each contained at least one affected sibling pair with severe end-stage disease (ascertained by hip or knee joint replacement surgery), we conducted a linkage analysis of chromosome 2q using 16 polymorphic microsatellite markers at an average spacing of one marker every 8.5 cM.


RESULTS
Our results provide suggestive evidence for a locus at 2q31 with a maximum multipoint logarithm of the odds score (MLS) of 1.22 which increased to 2.19 in those families concordant for hip-only disease (n = 311). This suggestive linkage was greater in male-hip families (MLS = 1.57, n = 71) than in female-hip families (MLS = 0.71, n = 132).


CONCLUSIONS
Chromosome 2q is likely to contain at least one susceptibility locus for OA.
Loughlin
J
J
University of Oxford, Institute of Molecular Medicine, Oxford, UK.
Mustafa
Z
Z
Smith
A
A
Irven
C
C
Carr
A J
AJ
Clipsham
K
K
Chitnavis
J
J
Bloomfield
V A
VA
McCartney
M
M
Cox
O
O
Sinsheimer
J S
JS
Sykes
B
B
Chapman
K E
KE
D000328:Adult; D000368:Aged; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000235:genetics*; D010375:Pedigree; D012720:Severity of Illness Index