Transcriptional regulation: Kamikaze activators.
Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.
Thomas
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Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, Gif-sur-Yvettte, 91198, France. thomas@cgm.cnrs-gif.fr
Tyers
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M
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D008025:Ligases / Q000378:metabolism; D051739:Microphthalmia-Associated Transcription Factor; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D012319:RNA Polymerase II / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D015533:Transcriptional Activation; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism*
D004268:DNA-Binding Proteins; D051739:Microphthalmia-Associated Transcription Factor; D015534:Trans-Activators; D014157:Transcription Factors; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases; D012319:RNA Polymerase II; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease; D008025:Ligases