Transient depression of excitatory synaptic transmission induced by adenosine uptake inhibition in rat hippocampal slices.
The transient property of the dipyridamole-induced depression of excitatory synaptic transmission was analyzed using field EPSPs (fEPSPs) recorded from the CA1 region in rat hippocampal slices. The fEPSPs were depressed by 1 microM dipyridamole and then gradually recovered to the control level. The depression was antagonized by aminophylline or DPCPX, although it was not significantly affected by DMPX. The results suggest that the fEPSP depression is induced by a mechanism through the A(1) receptor.
Narimatsu
E
E
Department of Physiology, Sapporo Medical University School of Medicine, South 1, West 17, Chuo-ku, Sapporo, Japan. enarimat@sapmed.ac.jp
Aoki
M
M
D000241:Adenosine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004176:Dipyridamole / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology*; D005246:Feedback / Q000187:drug effects / Q000502:physiology; D018756:GABA Antagonists / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology; D009474:Neurons / Q000737:chemistry / Q000201:enzymology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D014970:Xanthines / Q000494:pharmacology
D000700:Analgesics; D004791:Enzyme Inhibitors; D018691:Excitatory Amino Acid Antagonists; D018756:GABA Antagonists; D007004:Hypoglycemic Agents; D009281:Naphthalenes; D018377:Neurotransmitter Agents; D010726:Phosphodiesterase Inhibitors; D011500:Protein Synthesis Inhibitors; D018047:Receptors, Purinergic P1; D014970:Xanthines; D000628:Aminophylline; C058394:2-chloro-N(6)cyclopentyladenosine; D004176:Dipyridamole; D016291:Dizocilpine Maleate; C051360:1,3-dipropyl-8-cyclopentylxanthine; D011493:Protein Kinase C; D009355:Neomycin; C058819:calphostin C; D000241:Adenosine; D005905:Glyburide; D001640:Bicuculline