Pathogenesis of anaemia in hyperparathyroidism.
It is suggested that parathyroid hormone (PTH), when in excessive amounts, interferes with normal erythropoiesis by downregulating the erythropoietin receptors on erythroid progenitor cells in the bone marrow. Therefore, physiologic concentrations of EPO can no longer sustain normal red cell counts, so normocytic and normochromic anaemia ensues. In primary hyperparathyroidism (HPT), this effect is observed with very high concentrations of PTH. In secondary HPT during chronic renal failure, this effect is more pronounced because erythropoietin synthesis is impaired.
Sikole
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Department of Nephrology, Medical Faculty, University "Sv Kiril i Metodij"-Skopje, Republic of Macedonia.
D000740:Anemia / Q000209:etiology*; D004920:Erythropoiesis; D004921:Erythropoietin / Q000502:physiology; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000503:physiopathology*; D008954:Models, Biological; D010281:Parathyroid Hormone / Q000502:physiology
D010281:Parathyroid Hormone; D004921:Erythropoietin