title: Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products.
abstract: The influence of age on training-induced changes in resting and stimulated hemostatic potential was studied in three age categories (Cat I-III; 20-30 yr, 35-45 yr, and 50-60 yr, respectively) of sedentary men before and after 12 wk of training. Coagulation, fibrinolytic activity, and activation markers (reflecting fibrin formation and degradation) were determined. Physical conditioning resulted in a more pronounced increase in von Willebrand factor (vWF) and factor VIII clotting activity (FVIII:c) in Cat I and II and a more pronounced shortening of the activated partial thromboplastin time in all categories at maximal exertion and during recovery. Enhanced increases in tissue-type plasminogen activator (t-PA) antigen and activity and single-chain (sc) urokinase-type plasminogen activator (u-PA) at maximal exercise and 5 min of recovery were observed in all age groups after training. The effects on FVIII:c, vWF, and scu-PA were most pronounced in the youngest age group (Cat I). Increases in the marker of thrombin generation were highest in Cat III; no effect was seen on thrombin-antithrombin complex, plasmin-antiplasmin complex, and D-dimer in any of the age groups. We concluded that training enhances both coagulation and fibrinolytic potential during strenuous exercise. The effect on FVIII/vWF and t-PA/u-PA is most pronounced in younger individuals, whereas thrombin formation is most pronounced in older individuals.
authors.affiliation: Department of Medical Physiology and Sports Medicine, University of Utrecht, 3508 TA Utrecht, The Netherlands.
authors.forename: P J
authors.initials: PJ
authors.lastname: van den Burg
authors.forename: J E
authors.initials: JE
authors.lastname: Hospers
authors.forename: W L
authors.initials: WL
authors.lastname: Mosterd
authors.forename: B N
authors.initials: BN
authors.lastname: Bouma
authors.forename: I A
authors.initials: IA
authors.lastname: Huisveld
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood* / Q000502:physiology*; D000886:Anthropometry; D001810:Blood Volume; D005342:Fibrinolysis / Q000502:physiology; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion / Q000502:physiology*; D010809:Physical Fitness