title: [Coronary flow after successful angioplasty in patients with acute myocardial infarction: comparison between coronary flow reserve by nicorandil and papaverine].
abstract: In order to evaluate coronary flow response to 2 different vasodilators, nicorandil and papaverine, in patients with myocardial infarction, we measured coronary flow reserve using a Doppler guide wire in infarct-related and non infarct-related arteries. The study group consisted of 28 patients with first acute myocardial infarction 3 weeks after successful coronary angioplasty within 6 hr after symptom onset. Twelve patients with atypical chest pain served as the control group. Coronary flow reserve induced by intracoronary papaverine(12 mg) was lower in infarct-related arteries than in non infarct-related arteries, but there were no differences in coronary flow reserve induced by intracoronary nicorandil(1 mg) between infarct-related and non infarct-related arteries. Coronary flow reserve induced by nicorandil was lower than that by papaverine in non infarct-related arteries and the control group. However, there were no differences between coronary flow reserve induced by nicorandil and papaverine in infarct-related arteries. Vasodilatory response induced by nicorandil was relatively preserved in infarct-related arteries compared with papaverine. These results suggest that impairment of coronary microvascular response in infarct myocardium varies in the different sites acted on by different vasodilator agents.
authors.affiliation: Department of Cardiology, Tenri Hospital, Nara.
authors.forename: C
authors.initials: C
authors.lastname: Izumi
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: T
authors.initials: T
authors.lastname: Tamura
authors.forename: M
authors.initials: M
authors.lastname: Inoko
authors.forename: S
authors.initials: S
authors.lastname: Kitaguchi
authors.forename: T
authors.initials: T
authors.lastname: Hirozane
authors.forename: Y
authors.initials: Y
authors.lastname: Himura
authors.forename: K
authors.initials: K
authors.lastname: Iga
authors.forename: H
authors.initials: H
authors.lastname: Gen
authors.forename: T
authors.initials: T
authors.lastname: Konishi
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy; D020108:Nicorandil / Q000494:pharmacology*; D010208:Papaverine / Q000494:pharmacology*; D014465:Ultrasonics; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D020108:Nicorandil; D010208:Papaverine