Polynucleotides. XXII. Synthesis and properties of poly 7-deazainosinic acid.
Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin and the nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer has similar physical properties to poly(I), but has a low thermal stability in the double-stranded complex with poly(C). Poly(7-deaza I), in contrast, forms a more stable triple-stranded complex with poly(A) than 2 poly(I). poly(A), presumably due to the higher pK value.
Ikehara
M
M
Fukui
T
T
Koide
T
T
Inaba
J
J
D002942:Circular Dichroism; D004355:Drug Stability; D006358:Hot Temperature; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D011061:Poly A / Q000737:chemistry; D011069:Poly I / Q000138:chemical synthesis* / Q000737:chemistry*; D011070:Poly I-C / Q000737:chemistry; D011117:Polyribonucleotide Nucleotidyltransferase; D013056:Spectrophotometry, Ultraviolet; D014372:Tubercidin
D011061:Poly A; D011069:Poly I; C008957:poly(7-deazainosinic acid); D011117:Polyribonucleotide Nucleotidyltransferase; D014372:Tubercidin; D011070:Poly I-C