title: Amnioinfusion for umbilical cord compression in labour.
abstract: BACKGROUND
  Amnioinfusion aims to prevent or relieve umbilical cord compression during labour by infusing a solution into the uterine cavity.
  
  
  OBJECTIVE
  The objective of this review was to assess the effects of amnioinfusion on maternal and perinatal outcome for potential or suspected umbilical cord compression or potential amnionitis.
  
  
  METHODS
  The Cochrane Pregnancy and Childbirth Group trials register and the Cochrane Controlled Trials Register were searched.
  
  
  METHODS
  Randomised trials of amnioinfusion compared with no amnioinfusion in women with babies at risk of umbilical cord compression; and women at risk of intrauterine infection.
  
  
  METHODS
  Eligibility and trial quality were assessed by the reviewer.
  
  
  RESULTS
  Twelve studies were included. Transcervical amnioinfusion for potential or suspected umbilical cord compression was associated with the following reductions: fetal heart rate decelerations (relative risk 0.54, 95% confidence interval 0.43 to 0.68); caesarean section for suspected fetal distress (relative risk 0.35, 95% confidence interval 0.24 to 0.52); neonatal hospital stay greater than 3 days (relative risk 0.40, 95% confidence interval 0. 26 to 0.62); maternal hospital stay greater than 3 days (relative risk 0.46, 95% 0.29 to 0.74). Transabdominal amnioinfusion showed similar results. Transcervical amnioinfusion to prevent infection in women with membranes ruptured for more than 6 hours was associated with a reduction in puerperal infection (relative risk 0.50, 95% confidence interval 0.26 to 0.97).
  
  
  CONCLUSIONS
  Amnioinfusion appears to reduce the occurrence of variable heart rate decelerations and lower the use of caesarean section. However the studies were done in settings where fetal distress was not confirmed by fetal blood sampling. The results may therefore only be relevant where caesarean sections are commonly done for abnormal fetal heart rate alone. The trials reviewed are too small to address the possibility of rare but serious maternal adverse effects of amnioinfusion.
authors.affiliation: Department of Obstetrics and Gynaecology, Coronation Hospital and University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa. 091just@chiron.wits.ac.za
authors.forename: G J
authors.initials: GJ
authors.lastname: Hofmeyr
mesh_terms: D000650:Amnion; D002821:Chorioamnionitis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007267:Injections; D007744:Obstetric Labor Complications / Q000517:prevention & control*; D011247:Pregnancy; D014470:Umbilical Cord