title: Absolute configuration of scyphostatin
abstract: [reaction: see text] The absolute configuration of the side chain of scyphostatin (1) has been established. The chemical degradation of 1 gave 4 and 9, which correspond to the C7'-C12' and C13'-C16' fragments of the natural products, respectively. The spectroscopic data and [alpha]D values of both compounds were compared to those of authentic samples. The results show that the absolute configuration of 1 is 8'R,10'S,14'R.
authors.affiliation: Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.initials: S
authors.lastname: Saito
authors.initials: N
authors.lastname: Tanaka
authors.initials: K
authors.lastname: Fujimoto
authors.initials: H
authors.lastname: Kogen