[Degradation of phosphatidylnucleosides induced by phospholipases].
Hydrolysis of phosphatidylnucleosides, 5'-(rac-1-hexadecyl-2-palmitoyl-sn-glycero-3-phosphoryl)-3'-azido- 3'-deoxythymidine and -2',3'-didehydro-3'-deoxythymidine, effected by phospholipases (PL) A2, C, and D was studied to reveal the metabolism of these derivatives. It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides.
Novozhilova
T I
TI
State Research Institute of Organic Chemistry and Technology, Moscow, Russia.
Malekin
S I
SI
Kozhukhov
V I
VI
Krugliak
Iu L
IuL
Kurochkin
V K
VK
D019380:Anti-HIV Agents / Q000737:chemistry; D015224:Dideoxynucleosides / Q000737:chemistry*; D006868:Hydrolysis; D010712:Phosphatidic Acids / Q000737:chemistry*; D010739:Phospholipase D / Q000737:chemistry; D010740:Phospholipases / Q000737:chemistry; D010741:Phospholipases A / Q000737:chemistry; D054467:Phospholipases A2; D013379:Substrate Specificity; D010738:Type C Phospholipases / Q000737:chemistry
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D010712:Phosphatidic Acids; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D010738:Type C Phospholipases; D010739:Phospholipase D