Dupuytren's disease in type I diabetic subjects: investigation of biochemical markers of type III and I collagen.
OBJECTIVE
To clarify whether biochemical markers of collagen type III and I metabolism show alterations in type I diabetic subjects with Dupuytren's disease (DD) compared to those without DD.


METHODS
DD was assessed in a total of 28 type I diabetic subjects, mean age 43.4 +/- 9.5 (SD) and duration of diabetes 25.2 +/- 9.7 years. Concentrations of aminoterminal propeptide of type III procollagen (PIIINP), carboxyterminal propeptide of type I procollagen (PICP) and carboxyterminal cross-linked telopeptide of type I collagen (ICTP) in serum and excretion of cross-linked N-telopeptides of type I collagen (NTX) and deoxypyridinoline crosslinks (DPyr) into urine were measured.


RESULTS
The prevalence of DD was 32% (9 of 28 diabetic subjects). Average serum ICTP was 2.7 +/- 0.8 micrograms/l in subjects without DD and 3.6 +/- 1.2 micrograms/l with DD (p = 0.0276). No significant association between other collagen markers and DD was found. The reference intervals of PIIINP and ICTP were exceeded only in 1 and 2 subjects, respectively, and they both had DD.


CONCLUSIONS
The degradation of type I collagen might be increased in diabetic subjects with DD. The overall implication was that synthesis or degradation of type III and I collagen in diabetic subjects with DD did not differ enough from those without DD to reflect changes in the biochemical markers of type III and I collagen.
Arkkila
P E
PE
Department of Medicine, Helsinki University Central Hospital, Finland. perttu.arkkila@hus.fi
Koskinen
P J
PJ
Kantola
I M
IM
Rönnemaa
T
T
Seppänen
E
E
Viikari
J S
JS
D000328:Adult; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood*; D003094:Collagen / Q000097:blood* / Q000652:urine; D024042:Collagen Type I; D003432:Cross-Linking Reagents; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000473:pathology; D004387:Dupuytren Contracture / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood* / Q000652:urine; D015995:Prevalence; D011347:Procollagen / Q000097:blood*; D012016:Reference Values
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D003432:Cross-Linking Reagents; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide; C042813:procollagen type I carboxy terminal peptide; C036020:deoxypyridinoline; D003094:Collagen