title: Receptors mediating adenovirus attachment and internalization.
abstract: Adenovirus infection requires that the virus attach to cells and be internalized. Interaction between the viral fiber protein and specific cell surface receptors, such as the 46-kDa coxsackievirus and adenovirus receptor (CAR), is responsible for attachment; a second interaction between the viral penton base and cell surface integrins facilitates virus internalization. Expression of receptors may determine whether tissues are susceptible to adenovirus infection and adenovirus-mediated gene delivery.
authors.affiliation: Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, PA 19104, USA. bergelson@email.chop.edu
authors.forename: J M
authors.initials: JM
authors.lastname: Bergelson
mesh_terms: D000256:Adenoviridae / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D002213:Capsid / Q000502:physiology; D036022:Capsid Proteins; D003550:Cystic Fibrosis / Q000235:genetics / Q000628:therapy; D015316:Genetic Therapy; D015395:Histocompatibility Antigens Class I / Q000502:physiology; D006801:Humans; D011956:Receptors, Cell Surface / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology*
chemical_list: D036022:Capsid Proteins; D015395:Histocompatibility Antigens Class I; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C043322:penton protein, adenovirus