Vimentin expression in human squamous carcinoma cells: relationship with phenotypic changes and cadherin-based cell adhesion.
Phenotypic changes resembling an epithelial-to-mesenchymal transition often occur as epithelial cells become tumorigenic. Two proteins that have been implicated in this process are vimentin and N-cadherin. In this study, we sought to establish a link between expression of vimentin and N-cadherin as oral squamous epithelial cells undergo a morphologic change resembling an epithelial-to-mesenchymal transition. We found that N-cadherin and vimentin did not influence the expression of one another.
Islam
S
S
Department of Biology, University of Toledo, Ohio.
Kim
J B
JB
Trendel
J
J
Wheelock
M J
MJ
Johnson
K R
KR
D000818:Animals; D015820:Cadherins / Q000235:genetics / Q000502:physiology*; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000503:physiopathology; D002448:Cell Adhesion; D002999:Clone Cells; D006801:Humans; D007633:Keratins / Q000235:genetics; D007822:Laryngeal Neoplasms; D051379:Mice; D010641:Phenotype; D011994:Recombinant Proteins / Q000096:biosynthesis; D014162:Transfection; D014407:Tumor Cells, Cultured; D014746:Vimentin / Q000235:genetics*
D015820:Cadherins; D011994:Recombinant Proteins; D014746:Vimentin; D007633:Keratins