[The comparison of radiosensitivity between uterine cervical squamous carcinoma and adenocarcinoma].
OBJECTIVE
To compare the radiosensitivity of uterine cervical squamous carcinoma and adenocarcinoma.


METHODS
The shrinkage of tumor and the radiation-induced damage were compared between cervical squamous carcinoma and adenocarcinoma after twice afterloading radiotherapy. Proliferating cell nuclear antigen index (PI), detected immunohistochemically, was compared before and after radiotherapy between the two tumors.


RESULTS
Patients of squamous carcinoma with tumor shrinkage 50% or more accounted for 70% (21/30) and patients of adenocarcinoma accounted for 27% (4/15), which was statistically significant (P < 0.01). The radiation-induced damage grade II b-III accounted for 60% (18/30) in squamous carcinoma and for 20% (3/15) in adenocarcinoma, which was statistically significant (P < 0.05); PI decreased from 53.50% +/- 4.34% to 39.30% +/- 4.02% after radiotherapy in squamous carcinoma (P < 0.001), while PI decreased from 35.47% +/- 3.83% to 31.80% +/- 3.06% in adenocarcinoma (P > 0.05).


CONCLUSIONS
The radiosensitivity of cervical squamous carcinoma is higher than that of adenocarcinoma. The decrease of PI after radiotherapy may be a biological basis of radiosensitivity for uterine cervical squamous carcinoma.
Zhang
M
M
Cancer Hospital, Shanghai Medical University.
Cai
S
S
Shi
D
D
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011836:Radiation Tolerance; D002583:Uterine Cervical Neoplasms / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*
D018809:Proliferating Cell Nuclear Antigen