Comparative values of CSF-LDH isoenzymes in neurological disorders.
The present study was carried out to evaluate the usefulness of Cerebrospinal fluid (CSF) Lactate dehydrogenase (LDH) isoenzymes in the diagnosis in tuberculous meningitis (TBM), pyogenic meningitis (PM), viral encephalitis (VE) and hydrocephalus (HC). A characteristic dominance of isoenzymes in cerebrospinal fluid was observed: LDH4 in TBM while LDH3 in PM. However, in VE and HC, LDH2 and LDH1 were dominant respectively. The control subjects revealed the presence of isoenzymes LDH1 and LDH2 in very low concentrations. Pattern of LDH isoenzymes in CSF may serve as a diagnostic tool to differentiate these neurological disorders.
Kamat
D V
DV
C.B. Patel Research Centre for Chemistry and Biological Sciences, Bombay.
Chakravorty
B P
BP
D015415:Biomarkers / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000201:enzymology*; D003937:Diagnosis, Differential; D004587:Electrophoresis, Agar Gel; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000201:enzymology; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000201:enzymology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000201:enzymology
D015415:Biomarkers; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase