title: New C=C bond formation via nonstoichiometric titanium(IV) halide mediated vicinal difunctionalization of alpha,beta-unsaturated acyclic ketones
abstract: [reaction: see text] Highly stereoselective vicinal difuctionalization of alpha,beta-unsaturated ketones for the synthesis of multifunctionalized trisubstituted alkenes is described. The new reaction employs titanium(IV) halides (0.5 equiv) as promoters and inexpensive commercial chemicals as starting materials. The reaction can be performed at room temperature in a convenient vial without the protection of inert gases. Good to excellent yields and high Z/E stereoselectivity have been realized in most cases presented (16 examples).
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock 79409-1061, USA. qeggl@ttu.edu
authors.initials: G
authors.lastname: Li
authors.initials: J
authors.lastname: Gao
authors.initials: HX
authors.lastname: Wei
authors.initials: M
authors.lastname: Enright