Application of Carbopol to controlled release preparations I. Carbopol as a novel coating material.
We investigated the application of Carbopol(R) (CP) as a novel coating material prepared with various grades of CP having different degrees of cross-linking and molecular weights. Viscosity and spray mist size of CP aqueous solutions at various concentrations of CP were measured. Core tablets containing theophylline (TP), as a model drug, were coated with CP at various coating ratios. The TP release profile from the CP-coated tablets was studied by the JP13 paddle method. CP tablets were prepared by compressing CP powder, and the swelling behavior of the CP tablets in JP 1st fluid, purified water, and JP 2nd fluid was observed. The spray mist size of all CP aqueous solutions was small at a concentration of 1% and below, and drastically increased over a concentration of 1%. This result suggests that the appropriate concentration of the CP solution for coating is 1% or below. Sustained release of TP from the CP-coated tablets at a coating ratio of only 3% was observed in the JP 1st fluid and purified water, although fast release was observed in the JP 2nd fluid. The fast release in the latter fluid may be due to the fact that CP is an acid material. These results suggest that it is feasible to control the drug release by use of an extremely small amount of CP coating and that CP is useful as a novel coating material.
Muramatsu
M
M
Pharmaceutical Laboratories, Kissei Pharmaceutical Company, Limited, 4365-1 Kashiwabara, Hotaka, Minamiazumi, Nagano, Japan.
Kanada
K
K
Nishida
A
A
Ouchi
K
K
Saito
N
N
Yoshida
M
M
Shimoaka
A
A
Ozeki
T
T
Yuasa
H
H
Kanaya
Y
Y
D000180:Acrylic Resins; D001993:Bronchodilator Agents / Q000737:chemistry; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D010316:Particle Size; D011145:Polyvinyls / Q000737:chemistry*; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013806:Theophylline / Q000737:chemistry; D014783:Viscosity
D000180:Acrylic Resins; D001993:Bronchodilator Agents; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D011145:Polyvinyls; D013608:Tablets, Enteric-Coated; C006912:carboxypolymethylene; D013806:Theophylline