Role of acetylcholine in regulation of interaction between axon and Schwann cell during rhythmic excitation of nerve fibers.
Axon excitation increases the number of acetylcholine receptors (ACR) of the Schwann cell (SC) depending on the frequency of rhythmic excitation (RE) and on intercellular concentrations of K+, Ca2+, and acetylcholine. During RE, activity of axonal acetylcholine esterase is decreased, thus providing for high intercellular acetylcholine concentration. Increased intercellular concentration of acetylcholine activates phosphoinositide-specific phospholipase C (PIPLC) of the myelin nerve fiber. During RE, K+ depolarization and acetylcholine exocytosis can activate Ca2+ entry via Ca2+ channels, thus inducing SC ACR phosphorylation mediated by PIPLC stimulation.
Maximov
G V
GV
School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia. maxim@biophys.msu.ru
Revin
V V
VV
Grunyushkin
I P
IP
Kols
O R
OR
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001001:Anura; D001253:Astrocytes / Q000378:metabolism; D001369:Axons / Q000378:metabolism* / Q000502:physiology; D003386:Brachyura; D002118:Calcium / Q000502:physiology; D002450:Cell Communication; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D007477:Ions; D009412:Nerve Fibers / Q000378:metabolism*; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D011188:Potassium / Q000502:physiology; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism; D012583:Schwann Cells / Q000378:metabolism* / Q000502:physiology; D010738:Type C Phospholipases / Q000378:metabolism
D007477:Ions; D011950:Receptors, Cholinergic; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D000109:Acetylcholine; D011188:Potassium; D002118:Calcium