[The role of the intestines in the pathogenesis of acute pancreatitis: oxygen extraction and bacteria translocation in rats].
In experiment on 40 male rats of the Wistar line there was investigated the oxygen extraction (O2) and the bacteria translocation in 30 min, 2, 6, 12 and 24 hours after the stimulating operation (control group) and simulation of the ductal-hypertensive form of an acute experimental pancreatitis (AEP)--the main group. The data obtained witness the general extraction of O2 raising by 222% (P < 0.001) at average and lowering of its intestinal extraction in 30 min and 2 hours (by 33 and 31% at average, P < 0.05) and its raising in 24 hours by 138% (P < 0.001) at average also. These disorders had correlated with velocity of the intestinal E. coli reproduction and with the bacteria translocation on the way intestine-->mesenterial lymph nodes in 6 hours after the disease occurrence with preservation of the lymph nodes and the liver barrier function in the AEP duration over 24 hours. The data obtained had permitted to substantiate the necessity of the remedial measures complex application, directed on the frequency of purulent complications lowering.
Krivoruchko
I A
IA
Gusak
I V
IV
Smachilo
R M
RM
Red'kin
V E
VE
Golovina
O A
OA
Andreeshchev
S A
SA
Ivanova
Iu I
IuI
Shmal'ko
E E
EE
D000818:Animals; D016470:Bacteremia / Q000382:microbiology; D018988:Bacterial Translocation; D004195:Disease Models, Animal; D004754:Enterobacter / Q000502:physiology*; D004926:Escherichia coli / Q000502:physiology*; D007422:Intestines / Q000382:microbiology / Q000503:physiopathology*; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D010100:Oxygen / Q000097:blood*; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood / Q000209:etiology* / Q000382:microbiology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation; D013997:Time Factors
D010100:Oxygen