Palladium-mediated ring opening of hydroxycyclopropanes
[reaction: see text] The palladium-mediated ring opening of substituted cyclopropanols has been found to take place predominantly at the less substituted C-C bond. Thus, sequential application of the titanium-mediated cyclopropanation of esters and the palladium-mediated ring opening of the resulting cyclopropanols provides a convenient method for functionalizing monosubstituted olefins.
Park
SB
Department of Chemistry, University of Alabama, Tuscaloosa 35487, USA.
Cha
JK