Applicability of a circulatory model for determining the parameters of kinetics of endogenously produced compounds.
The applicability of circulatory model approach for determining the kinetic parameters of endogenously produced substances has been demonstrated based on the assumption that the behaviour of newly produced molecules of a compound inside its production spaces is the same as that of the molecules returned due to recirculation of blood. While extraction and transmission parameters can be estimated by using tracer data, total mass cannot be determined without additional information. This information could be obtained from data of some suitable metabolite by using double tracer method. Circulatory model is especially suitable for studies of substances with a fast kinetics and renewal if blood (plasma) flow is measured independently.
Vítek
F
F
Institute of Biophysics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
Pilo
A
A
Pich
J
J
Iervasi
G
G
Zitko
M
M
Clerico
A
A
D001775:Blood Circulation; D008955:Models, Cardiovascular; D010599:Pharmacokinetics; D011868:Radioisotopes
D011868:Radioisotopes