N-cadherin-mediated cell contact regulates ovarian surface epithelial cell survival.
The present study shows that in cells derived from the rat ovarian surface epithelium (i.e. ROSE-179 cells) the adhesion protein, N-cadherin, binds to the receptor for fibroblast growth factor (FGF). This interaction likely accounts for the ability of the N-cadherin antibody to decrease the activation (i.e. tyrosine phosphorylation) of the FGF receptor and induce apoptosis. The loss of N-cadherin-mediated cell contact also results in the accumulation of beta-catenin within the nucleus. Since beta-catenin also functions as a transcription factor, nuclear beta-catenin may promote mRNA synthesis that is required for ROSE-179 cells to undergo apoptosis in response to serum/calcium withdrawal. This hypothesis requires further testing and validation.
Peluso
J J
JJ
Departments of Physiology and Obstetrics and Gynecology, University of Connecticut Health Center, Farmington 06030, USA. peluso@nso2.uchc.edu
D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology; D005260:Female; D006801:Humans; D010053:Ovary / Q000166:cytology / Q000502:physiology*; D015534:Trans-Activators; D051176:beta Catenin
C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin