Dynamic laser speckle pattern in monitoring of local deformation of tablet surface after compression.
A method and a sensor device were developed to detect dynamic laser speckle pattern for monitoring of deformation of pharmaceutical tablets after compression. Temporal variations in optical signal revealed local surface deformation of the ibuprofen and the starch acetate tablets as well as anisotropy of tablet surfaces at the inspection location.
Silvennoinen
R
R
Vaisala Laboratory, Department of Physics, University of Joensuu, PO Box 111, FIN-80101, Joensuu, Finland. raimo.silvennoinen@joensuu.fi
Hyvärinen
V
V
Raatikainen
P
P
Peiponen
K
K
D002214:Capsules; D002626:Chemistry, Pharmaceutical / Q000379:methods / Q000592:standards*; D007052:Ibuprofen / Q000008:administration & dosage; D007834:Lasers; D013213:Starch / Q000031:analogs & derivatives; D013997:Time Factors
D002214:Capsules; D013213:Starch; C050766:starch acetate; D007052:Ibuprofen