title: Quaternary ammonium compound stresses induce specific variations in fatty acid composition of Pseudomonas aeruginosa.
abstract: The involvement of cell membrane fatty acids in resistance of Pseudomonas aeruginosa to Quaternary Ammonium Compounds (QACs) stresses was investigated. The strain was grown in a medium with increasing concentrations of different biocides: two QACs, and two non-QACs. In the presence of two QACs only, the strain was able to grow with increasing concentrations. During cellular adaptation to QACs, the resistance to the same biocide increased. A principal component analysis was performed with whole of fatty acid compositions which highlighted a specific variation for the cultures in presence of QACs. These modifications gave evidence of the outer membrane involvement in cellular response to the presence of QACs.
authors.affiliation: Département de Microbiologie Industrielle, Ecole nationale Supérieure des Industries Alimentaires, Massy, France. mechin@ensia.inra.fr
authors.forename: L
authors.initials: L
authors.lastname: Guerin-Mechin
authors.forename: F
authors.initials: F
authors.lastname: Dubois-Brissonnet
authors.forename: B
authors.initials: B
authors.lastname: Heyd
authors.forename: J Y
authors.initials: JY
authors.lastname: Leveau
mesh_terms: D005227:Fatty Acids / Q000032:analysis*; D008563:Membrane Lipids / Q000032:analysis*; D011550:Pseudomonas aeruginosa / Q000737:chemistry* / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D008563:Membrane Lipids; D000644:Quaternary Ammonium Compounds