[Th1-Th2 cytokine correlates (INF-gamma and IL-4) in splenectomized patients].
This paper attempts to explain if immunodepression in patients who had undergone a splenectomy may be due to altered balance between Th1-Th2 lymphocyte subpopulations, as shown in several studies on phagocyte and lymphocyte cells. This was achieved by dosing serum levels of IFNg, produced by Th1 lymphocytes and IL-4, produced by Th2 lymphocytes. Final analysis showed immunodepression in splenectomized patients but also emphasized that in 70% of all cases, there is functional damage of T-lymphocytes that continues for several years after the surgery involving both cellular and humoral immunity. Immunoglobulin dosage allows the increase of IgE to be seen in 50% of the splenectomized patients studied, all with allergic symptoms that appeared after the operation. The production of IgE is stimulated by Th2 lymphocytes. This leaves one to believe that splenectomy may favour the persistence of allergens in the blood, the appearance of allergic symptoms and the increase of IgE serum levels in patients with normal Th2 functioning and consequently, with normal or increased IL-4 serum levels.
Miniello
S
S
Istituto di Chirurgia Generale II, Università degli Studi di Bari.
Jirillo
E
E
Urgesi
G
G
D'Abbicco
D
D
Altamura
M
M
Tomasicchio
N
N
Bonomo
G M
GM
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007136:Immunoglobulins / Q000097:blood; D007371:Interferon-gamma / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013156:Splenectomy / Q000009:adverse effects; D018417:Th1 Cells; D018418:Th2 Cells
D015415:Biomarkers; D007136:Immunoglobulins; D015847:Interleukin-4; D007371:Interferon-gamma