title: [Pregnancy in women with diabetes mellitus type I: maternal and perinatal complications, in spite of good blood glucose control].
abstract: OBJECTIVE
  To examine the maternal and neonatal outcome of pregnancies of women with type I diabetes mellitus.
  
  
  METHODS
  Retrospective.
  
  
  METHODS
  The medical records of pregnancies (> or = 16 weeks) in women with type I diabetes mellitus between 1986/'97 were studied in University Medical Center Utrecht, Academic Hospital Groningen and Isala Clinics, location 'De Weezenlanden', Zwolle, the Netherlands.
  
  
  RESULTS
  During the study period, 172 women had 220 pregnancies: 212 single and 8 twin pregnancies. The mean age was 29.1 years (SD: 4.1), the mean duration of standing of the diabetes was 12 years (range: 1-32) and the mean concentration of glycosylated haemoglobin (HbA1c) was 6.3% at 10 weeks of pregnancy. The incidence of children with congenital malformations was 4 times higher (n = 19; 9.0%) than that in the Dutch population (2%). Macrosomia occurred in 92 children (43.4%) and perinatal mortality in 7 (3.3%). Maternal hypertensive complications occurred in 39 single pregnancies (18.4%), which is 2-3 times more often than in the Dutch population.
  
  
  CONCLUSIONS
  In type I diabetic women maternal complications, perinatal morbidity and mortality are increased, despite near optimal glycaemic control.
authors.affiliation: Universitair Medisch Centrum locatie Wilhelmina Kinderziekenhuis, Utrecht.
authors.forename: I M
authors.initials: IM
authors.lastname: Evers
authors.forename: A M
authors.initials: AM
authors.lastname: Bos
authors.forename: A L
authors.initials: AL
authors.lastname: Aalders
authors.forename: E
authors.initials: E
authors.lastname: van Ballegooie
authors.forename: H W
authors.initials: HW
authors.lastname: de Valk
authors.forename: J J
authors.initials: JJ
authors.lastname: van Doormaal
authors.forename: H G
authors.initials: HG
authors.lastname: ter Brugge
authors.forename: G H
authors.initials: GH
authors.lastname: Visser
mesh_terms: D000328:Adult; D017668:Age of Onset; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000401:mortality*; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D008297:Male; D008499:Medical Records; D009426:Netherlands / Q000453:epidemiology; D011159:Population Surveillance; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology*; D011256:Pregnancy Outcome; D011254:Pregnancy in Diabetics / Q000453:epidemiology*; D012189:Retrospective Studies; D014427:Twins
chemical_list: D006442:Glycated Hemoglobin