Reduced transendothelial migration of monocytes infected by Coxiella burnetii.
The migratory properties of THP1 monocytes infected by Coxiella burnetii were determined in a transmigration assay across a human microvascular endothelial cell monolayer. Transendothelial migration of monocytes infected by virulent, but not avirulent, C. burnetii was inhibited. This inhibition was observed in spite of conserved adherence properties of infected monocytes.
Dellacasagrande
J
J
Unité des Rickettsies, Université de la Méditerranée, CNRS UPRESA 6020, Faculté de Médecine, 13385 Marseille Cedex 05, France.
Moulin
P A
PA
Guilianelli
C
C
Capo
C
C
Raoult
D
D
Grau
G E
GE
Mege
J L
JL
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D002465:Cell Movement; D016997:Coxiella burnetii / Q000472:pathogenicity*; D004730:Endothelium, Vascular / Q000166:cytology / Q000382:microbiology*; D006801:Humans; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000382:microbiology*