[Vitamin B 6 metabolism in phenylketonuria].
Based on the analysis of the dependence of 4-pyridoxic acid urinary excretion from pyridoxal-5'-phosphate blood plasma level and its statistic distribution it has been shown that vitamin B-6 metabolism in children suffering from phenylketonuria and therefore the criteria of the body saturation with this vitamin differ from those for healthy people. Increased pyridoxal-5'-phosphate blood plasma level has been demonstrated for PKU children. The concentration of 11 ng/ml should be considered as a bottom border of the adequate supply with vitamin B-6. The elevated vitamin B-2 intake approximates vitamin B-6 status indexes of sick children to those usually measured in healthy children. The necessity for the reevaluation of vitamin B-2 and B-6 optimal diet content under this disease and its biochemical validation are discussed.
Kharitonchik
L A
LA
Institute of Nutrition at Russian Medical Academy, Moscow.
Kodentsova
V M
VM
Vrzhesinskaia
O A
OA
Denisova
S N
SN
Spirichev
V B
VB
D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010661:Phenylketonurias / Q000378:metabolism*; D011732:Pyridoxal Phosphate / Q000097:blood; D011735:Pyridoxic Acid / Q000652:urine; D011736:Pyridoxine / Q000378:metabolism*; D012256:Riboflavin / Q000378:metabolism
D011735:Pyridoxic Acid; D011732:Pyridoxal Phosphate; D011736:Pyridoxine; D012256:Riboflavin