Cellulose and calcium lower the incidence of chemically-induced colon tumors in rats.
In a 30-week preliminary study and a follow-up 22-week study (2 x 2 factorial), dimethylhydrazine (DMH) injections effectively induced colon tumors in Fischer-344 rats. How this incidence of colon tumors might be affected by cellulose (preliminary study) or by calcium and folic acid (follow-up study) was examined. Cellulose in the diet appeared to provide some protection against DMH-induced colon tumors, but the protective effect of calcium was more evident; normal levels of calcium (500 mg per 100 g diet), but not of folic acid (0.1 mg per 100 g diet), provided protection against colon tumors. The effect due to calcium was observed whether viewed in terms of total number of tumors (p < 0.01) or number of tumors per tumor-bearing rat (p < 0.01).
Ranhotra
G S
GS
American Institute of Baking, Manhattan, KS, USA.
Gelroth
J A
JA
Glaser
B K
BK
Schoening
P
P
Brown
S E
SE
D000230:Adenocarcinoma / Q000517:prevention & control; D000236:Adenoma / Q000517:prevention & control; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D002136:Calcium, Dietary / Q000627:therapeutic use*; D002273:Carcinogens; D002482:Cellulose / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004043:Dietary Fiber / Q000627:therapeutic use*; D004127:Dimethylhydrazines; D004195:Disease Models, Animal; D005492:Folic Acid / Q000627:therapeutic use*; D008297:Male; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344
D016588:Anticarcinogenic Agents; D002136:Calcium, Dietary; D002273:Carcinogens; D004043:Dietary Fiber; D004127:Dimethylhydrazines; D002482:Cellulose; D005492:Folic Acid