Direct synthesis of beta-aminoketones from amides via novel sequential nucleophilic substitution/Michael reaction
[reaction: see text] The synthesis of beta-aminoketones from amides can be achieved in a process consisting of sequential nucleophilic substitution at the carbonyl group by vinylmagnesium bromide followed by Michael reaction after quench of the first reaction by water.
Gomtsyan
A
Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, Illinois 60064, USA. arthur.r.gomtsyan@abbott.com