title: Left ventricular function in adolescents and adults with restrictive ventricular septal defect and moderate left-to-right shunting.
abstract: BACKGROUND
  The long-term haemodynamic effects of a restrictive ventricular septal defect permitting moderate left-to-right shunting are not known.
  
  
  METHODS
  Echocardiographic measurements of left heart dimensions and function were compared between a group of 9 older children and adults (median age 21 years, range 12-24.5 years) having restrictive ventricular septal defects (median Qp/Qs 1.7, range 1.4-2.1) and a group of 10 age matched controls.
  
  
  RESULTS
  Left ventricular mass indexed to body surface area was significantly greater in subjects than in controls (102+/-29 vs. 75+/-13 g/m2, p=0.02), although there was no significant difference in the ratio of mass to volume. There were no significant differences between indexes of left ventricular systolic function. Ratios of peak early to late diastolic ventricular filling were lower in those with septal defects (1.5+/-0.3 vs. 1.8+/-0.3, p=0.03), but there were no differences in other indexes of diastolic function.
  
  
  CONCLUSIONS
  Resting left ventricular function does not appear to have deteriorated by early adult life in patients with restrictive ventricular septal defects and moderate volume loading. This would support a continued conservative approach to management in these patients.
authors.affiliation: Royal Hospital for Sick Children, Edinburgh, UK. a.magee@rbh.nthames.nhs.uk
authors.forename: A G
authors.initials: AG
authors.lastname: Magee
authors.forename: L
authors.initials: L
authors.lastname: Fenn
authors.forename: J
authors.initials: J
authors.lastname: Vellekoop
authors.forename: M J
authors.initials: MJ
authors.lastname: Godman
mesh_terms: D000293:Adolescent; D000328:Adult; D002306:Cardiac Volume; D016022:Case-Control Studies; D002648:Child; D015150:Echocardiography, Doppler; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000503:physiopathology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology*