Amyloid beta-protein length and cerebral amyloid angiopathy-related haemorrhage.
The relationship between amyloid beta-protein (A beta) length and the apolipoprotein E (APOE) epsilon 2 allele, which is over-represented in cerebral amyloid angiopathy-related haemorrhage (CAAH), has not previously been examined. Of 57 CAA patients studied, 37 had CAAH. All patients, particularly those with CAAH had more blood vessels immunoreactive for A beta 40 than A beta 42 in both the leptomeninges and cerebral cortex. CAAH patients had more A beta 40-immunoreactive blood vessels in the leptomeninges (p < 0.001) and cortex (p = 0.027) than had non-haemorrhage patients. Cortical blood vessels, the usual source of haemorrhage in CAAH, were more frequently A beta 42 immunoreactive in APOE epsilon 2 carriers than in non-epsilon 2 carriers (p = 0.022). The APOE epsilon 2 allele may predispose to CAAH by increasing the seeding of cortical blood vessels by A beta 42.
McCarron
M O
MO
Department of Neurology, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK.
Nicoll
J A
JA
Stewart
J
J
Cole
G M
GM
Yang
F
F
Ironside
J W
JW
Mann
D M
DM
Love
S
S
Graham
D I
DI
D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001057:Apolipoproteins E / Q000235:genetics; D016657:Cerebral Amyloid Angiopathy / Q000473:pathology / Q000503:physiopathology*; D002536:Cerebral Arteries / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008578:Meninges / Q000473:pathology; D017434:Protein Structure, Tertiary
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E