title: Infective endocarditis complicated with progressive heart failure due to beta-lactamase-producing Cardiobacterium hominis.
abstract: We describe a 66-year-old woman with infective endocarditis due to Cardiobacterium hominis whose condition, complicated by severe aortic regurgitation and congestive heart failure, necessitated aortic valve replacement despite treatment with ceftriaxone followed by ciprofloxacin. The blood isolate of C. hominis produced beta-lactamase and exhibited high-level resistance to penicillin (MIC, >==256 microgram/ml) and reduced susceptibility to vancomycin (MIC, 8 microgram/ml).
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: P L
authors.initials: PL
authors.lastname: Lu
authors.forename: P R
authors.initials: PR
authors.lastname: Hsueh
authors.forename: C C
authors.initials: CC
authors.lastname: Hung
authors.forename: L J
authors.initials: LJ
authors.lastname: Teng
authors.forename: T N
authors.initials: TN
authors.lastname: Jang
authors.forename: K T
authors.initials: KT
authors.lastname: Luh
mesh_terms: D000368:Aged; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery; D002443:Ceftriaxone / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000188:drug therapy; D006092:Gram-Negative Facultatively Anaerobic Rods / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D006333:Heart Failure / Q000150:complications* / Q000382:microbiology / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology; D013624:Taiwan; D014640:Vancomycin / Q000494:pharmacology; D001618:beta-Lactamases / Q000032:analysis
chemical_list: D010406:Penicillins; D002939:Ciprofloxacin; D014640:Vancomycin; D002443:Ceftriaxone; D001618:beta-Lactamases