title: [Topical administration of capsaicin in dermatology for treatment of itching and pain].
abstract: OBJECTIVE
  Treatment of pruritus as observed in many dermatological and internal diseases may be very often disappointing. There are many reports describing the topical use of capsaicin, the pungent agent in red pepper. Long term administration of capsaicin depletes neuropeptides in unmyelinated, polymodal C-type and small myelinated A delta-type cutaneous nerves that conduct pruritus and pain.
  
  
  METHODS
  The aim of this study was to evaluate the efficacy, safety and practicability of capsaicin in the treatment of pruritus and pain of different origin in a total of 40 patients.
  
  
  RESULTS
  Capsaicin suppressed completely itch in all patients.
  
  
  CONCLUSIONS
  In addition to its excellent antipruritic and analgetic effect, capsaicin significantly contributed to healing of some dermatoses, such as prurigo nodularis and psoriasis.
authors.affiliation: Universitäts-Hautklinik der Westfälischen Wilhelms-Universität Münster. reimaso@uni-muenster.de
authors.forename: S
authors.initials: S
authors.lastname: Reimann
authors.forename: T
authors.initials: T
authors.lastname: Luger
authors.forename: D
authors.initials: D
authors.lastname: Metze
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002211:Capsaicin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D008854:Microscopy, Electron; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000150:complications / Q000473:pathology; D013997:Time Factors
chemical_list: D002211:Capsaicin