title: Synthesis of the C1-C13 fragment of leucascandrolide A.
abstract: [reaction: see text] The synthesis of the C1-C13 fragment 3 of leucascandrolide A has been completed utilizing a stereoselective and regioselective reductive cleavage of a highly functionalized spiroketal to incorporate the cis-2,6-disubstituted tetrahydropyan. The spiroketal was constructed by addition of a lithiated pyrone 5 to aldehyde 6.
authors.affiliation: Venable and Kenan Laboratories of Chemistry, The University of North Carolina at Chapel Hill, 27599-3290, USA. crimmins@email.unc.edu
authors.forename: M T
authors.initials: MT
authors.lastname: Crimmins
authors.forename: C A
authors.initials: CA
authors.lastname: Carroll
authors.forename: B W
authors.initials: BW
authors.lastname: King
mesh_terms: D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D012717:Sesquiterpenes; C408748:leucascandrolide A