title: Dynamic kinetic resolution of alpha-hydroxy acid esters
abstract: [formula: see text] Enzymatic resolution in combination with ruthenium-catalyzed racemization of the substrate led to dynamic kinetic resolution of alpha-hydroxy esters in good yields and excellent ee's. Studies of different parameters showed that the best results were obtained using Pseudomonas cepacia lipase, ruthenium catalyst 3, and 4-chlorophenyl acetate as acyl donor in cyclohexane.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
authors.initials: FF
authors.lastname: Huerta
authors.initials: YR
authors.lastname: Laxmi
authors.initials: JE
authors.lastname: Backvall