title: Interaction between HLA-DR2 and abnormal brain MRI in optic neuritis and early MS. Optic Neuritis Study Group.
abstract: The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI.
authors.affiliation: Department of Neurology, University of California, San Francisco, CA, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Hauser
authors.forename: J R
authors.initials: JR
authors.lastname: Oksenberg
authors.forename: R
authors.initials: R
authors.lastname: Lincoln
authors.forename: J
authors.initials: J
authors.lastname: Garovoy
authors.forename: R W
authors.initials: RW
authors.lastname: Beck
authors.forename: S R
authors.initials: SR
authors.lastname: Cole
authors.forename: P S
authors.initials: PS
authors.lastname: Moke
authors.forename: K E
authors.initials: KE
authors.lastname: Kip
authors.forename: R L
authors.initials: RL
authors.lastname: Gal
authors.forename: D T
authors.initials: DT
authors.lastname: Long
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000483:Alleles; D001921:Brain / Q000187:drug effects / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D015802:HLA-DR2 Antigen / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D009902:Optic Neuritis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D015802:HLA-DR2 Antigen; D011241:Prednisone; D008775:Methylprednisolone