title: Quantitative comparison of bone growth behavior in granules of Bioglass, A-W glass-ceramic, and hydroxyapatite.
abstract: The hypothesis that bioactive glass particulate increases the rate of bone proliferation over that of synthetic hydroxyapatite and bioactive glass-ceramic was tested in these experiments. Three types of bioactive particles-45S5 Bioglass(R), synthetic hydroxyapatite, and A-W glass-ceramic-were implanted in 6-mm-diameter holes drilled in the femoral condyles of mature rabbits. Bone growth rate was measured using an image processor. 45S5 Bioglass(R) produced bone more rapidly than either A-W glass-ceramic or hydroxyapatite. At the later time periods, 45S5 Bioglass(R) was resorbed more quickly than A-W glass-ceramic. Synthetic hydroxyapatite was not resorbed at all. Backscattered electron imaging suggested that the resorption process occurred by solution-mediated dissolution, which produced chemical changes in the enclosed particulate. It was concluded that the rate of bone growth correlates with the rate of dissolution of silica as the particles resorb.
authors.affiliation: Department of Orthopedic Surgery, Artificial Joint Section and Biomaterial Laboratory, Osaka-Minami National Hospital. 2-1, Kidohigashi-machi, Kawachinagano-City, Osaka, 586-8521, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Oonishi
authors.forename: L L
authors.initials: LL
authors.lastname: Hench
authors.forename: J
authors.initials: J
authors.lastname: Wilson
authors.forename: F
authors.initials: F
authors.lastname: Sugihara
authors.forename: E
authors.initials: E
authors.lastname: Tsuji
authors.forename: M
authors.initials: M
authors.lastname: Matsuura
authors.forename: S
authors.initials: S
authors.lastname: Kin
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Mizokawa
mesh_terms: D000818:Animals; D001031:Apatites; D001672:Biocompatible Materials; D001846:Bone Development / Q000187:drug effects*; D001842:Bone and Bones / Q000033:anatomy & histology / Q000166:cytology; D002516:Ceramics; D017886:Durapatite; D005269:Femur / Q000254:growth & development; D008863:Microspheres; D011817:Rabbits; D012824:Silicic Acid; D013997:Time Factors
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; C022107:Bioglass; C077777:apatite-wollastonite-containing glass ceramic; D012824:Silicic Acid; D017886:Durapatite