title: Altered expression of members of the IGF-axis in hepatoblastomas.
abstract: Previous reports have demonstrated that expression of insulin-like growth factor 2 (IGF2) is altered in hepatoblastoma. Using RNAase protection analysis (RPA), we examined the gene expression for IGF1, IGF2, IGF1R, M6P/IGF2R, IGFBP-1 and IGFBP-2 in a series of hepatoblastomas with corresponding normal liver from the same individuals. The results show that the expression of the IGF-axis members included in the present study are altered between tumour and normal, and indicate that the IGF-axis may be involved in hepatoblastoma development.
authors.affiliation: Dept. of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
authors.forename: S G
authors.initials: SG
authors.lastname: Gray
authors.forename: T
authors.initials: T
authors.lastname: Eriksson
authors.forename: C
authors.initials: C
authors.lastname: Ekström
authors.forename: S
authors.initials: S
authors.lastname: Holm
authors.forename: D
authors.initials: D
authors.lastname: von Schweinitz
authors.forename: P
authors.initials: P
authors.lastname: Kogner
authors.forename: B
authors.initials: B
authors.lastname: Sandstedt
authors.forename: T
authors.initials: T
authors.lastname: Pietsch
authors.forename: T J
authors.initials: TJ
authors.lastname: Ekström
mesh_terms: D016147:Genes, Tumor Suppressor; D018197:Hepatoblastoma / Q000235:genetics*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics*; D009124:Muscle Proteins / Q000235:genetics; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated; D017451:Receptors, Somatomedin / Q000235:genetics; D013002:Somatomedins / Q000235:genetics*
chemical_list: C094335:H19 long non-coding RNA; D018969:Insulin-Like Growth Factor Binding Proteins; D009124:Muscle Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D022661:RNA, Untranslated; D017451:Receptors, Somatomedin; D013002:Somatomedins