title: Cyclic AMP and fluconazole resistance in Saccharomyces cerevisiae.
abstract: Cyclic AMP (cAMP) is involved in the stress response in Saccharomyces cerevisiae. We show that cAMP is required for resistance to fluconazole in S. cerevisiae. In addition, activation of Ras2, a regulator of cAMP generation, results in some protection from fluconazole toxicity in a fashion independent of the efflux transporter Pdr5p.
authors.affiliation: Department of Internal Medicine Specialties, Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. dkontoyi@notes.mdacc.tmc.edu
authors.forename: D P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: S
authors.initials: S
authors.lastname: Rupp
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole; D000242:Cyclic AMP