title: Using polarization effects to alter chemical reactivity: A simple host which enhances amine nucleophilicity
abstract: The rational design of a bis(phosphine oxide) host which is capable of binding a benzylic amine is presented. The ability of this host to increase the rate of addition of 4-fluorobenzylamine to N-phenylmaleimide is rationalized in terms of the enhancement of the nucleophilicity of the benzylic amine.
authors.affiliation: School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.
authors.initials: PR
authors.lastname: Ashton
authors.initials: P
authors.lastname: Calcagno
authors.initials: N
authors.lastname: Spencer
authors.initials: KD
authors.lastname: Harris
authors.initials: D
authors.lastname: Philp