A single amino acid change in the murine leukemia virus capsid gene responsible for the Fv1(nr) phenotype.
The nr allele at the mouse Fv1 restriction locus governs resistance to B-tropic and some N-tropic murine leukemia viruses (MLVs). Sequence analysis and site-specific mutagenesis of N-tropic MLVs identified a single amino acid difference responsible for this restriction that is distinct from the site that governs N or B tropism. Viruses with other substitutions at this site were evaluated for altered replication patterns.
Jung
Y T
YT
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Kozak
C A
CA
D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D002213:Capsid / Q000235:genetics*; D002460:Cell Line; D005622:Friend murine leukemia virus / Q000235:genetics* / Q000472:pathogenicity*; D051379:Mice; D008969:Molecular Sequence Data; D010641:Phenotype