title: Plasma interleukin-4, interleukin-10, and interleukin-13 concentrations and complications after coronary artery bypass graft surgery.
abstract: OBJECTIVE
  To determine whether plasma interleukin (IL)-4, IL-10, and IL-13 concentrations are associated with complications after coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB).
  
  
  METHODS
  Prospective descriptive study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Thirty-two patients during and 24 hours after CABG surgery.
  
  
  RESULTS
  Hemodynamic measurements and blood samples were obtained from 32 patients during and after surgery. Coagulation, pulmonary, and cardiovascular functions were specifically assessed during the first 24 hours postoperatively. Plasma IL-4 and IL-13 levels remained unchanged during CABG surgery. In contrast, plasma IL-10 concentrations increased by 117-fold in the immediate postoperative period and returned to pre-CPB values by 24 hours postoperatively. Plasma IL-10 levels were not different in patients with or without cardiovascular impairment, coagulation disorders, and lung injury. Plasma IL-10 levels did not correlate with the leukocyte count, the amount of catecholamines infused, or the duration of CPB.
  
  
  CONCLUSIONS
  The present results suggest that the development of post-CABG surgery complications might be linked to an insufficient production of anti-inflammatory cytokines, such as IL-4, IL-10, or IL-13, which are unable to counteract the overproduction of inflammatory cytokines.
authors.affiliation: Département d'Anesthesie-Réanimation, CHU Dupuytren, Limoges, France.
authors.forename: N
authors.initials: N
authors.lastname: Nathan
authors.forename: P M
authors.initials: PM
authors.lastname: Preux
authors.forename: P
authors.initials: P
authors.lastname: Feiss
authors.forename: Y
authors.initials: Y
authors.lastname: Denizot
mesh_terms: D000368:Aged; D002316:Cardiotonic Agents / Q000627:therapeutic use; D001026:Coronary Artery Bypass; D004280:Dobutamine / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D018793:Interleukin-13 / Q000097:blood*; D015847:Interleukin-4 / Q000097:blood*; D007432:Intraoperative Period; D008297:Male; D011229:Preanesthetic Medication; D011446:Prospective Studies; D011652:Pulmonary Circulation / Q000502:physiology; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D018793:Interleukin-13; D016753:Interleukin-10; D015847:Interleukin-4; D004280:Dobutamine