Temporal lobe epilepsy with and without psychosis: exploration of hippocampal pathology including that in subpopulations of neurons defined by their content of immunoreactive calcium-binding proteins.
We have investigated relationships between hippocampal/temporal lobe neuropathology and psychosis in subjects with temporal lobe epilepsy, paying particular attention to possible differences in density of hippocampal neurons immunoreactive for calcium-binding proteins. There was a trend for a greater prevalence of left handedness in the psychotic (n = 6) than the non-psychotic (n = 26) cases (P = 0.0504). Psychotic cases also differed from non-psychotic ones in having: (1) more focal lesions outside the hippocampus (P = 0.006); (2) less severe CAI neuron loss (P = 0.015); and (3) a trend, after Bonferroni correction, for a higher density of calbindin-immunoreactive neurons in the CA4 (P = 0.022). An additional finding was that dentate granule cell dispersion was significantly associated with the presence of a reduced density of calretinin-immunoreactive neurons in CA4 (P = 0.002) and with a more severe loss of CA4 neurons visible with Nissl stain (P = 0.003). Thus, cases of temporal lobe epilepsy with psychosis were distinguishable on the basis of a higher density of calbindin-reactive neurons in CA4 as well as on more general aspects of their pathology.
Suckling
J
J
Department of Neuropathology, Oxford University, Radcliffe Infirmary, UK.
Roberts
H
H
Walker
M
M
Highley
J R
JR
Fenwick
P
P
Oxbury
J
J
Esiri
M M
MM
D000293:Adolescent; D000328:Adult; D000906:Antibodies; D064032:Calbindin 2; D002452:Cell Count; D002648:Child; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D009474:Neurons / Q000737:chemistry* / Q000473:pathology; D010320:Parvalbumins / Q000032:analysis* / Q000276:immunology; D011618:Psychotic Disorders / Q000209:etiology / Q000473:pathology*; D064030:S100 Calcium Binding Protein G / Q000032:analysis* / Q000276:immunology; D013702:Temporal Lobe / Q000473:pathology
D000906:Antibodies; C576764:CALB2 protein, human; D064032:Calbindin 2; D010320:Parvalbumins; D064030:S100 Calcium Binding Protein G