title: Successful treatment of large malignant tumor involving the skull base by radiosurgery combined with intraarterial chemotherapy and embolization.
abstract: Stereotactic radiosurgery can be used to treat malignant tumors involving the skull base. While it avoids extensive sacrifice of the normal structures surrounding the tumor, radiosurgery does not eradicate the tumor mass immediately. We present a patient with a large hypervascular malignant tumor involving the skull base that resulted in intracranial hypertension. He was successfully treated with stereotactic radiosurgery combined with intra-arterial chemotherapy and embolization of the arteries feeding the tumor. We discuss radiosurgery, chemotherapy, embolization and other therapeutic modalities for treating large malignant tumors involving the skull base.
authors.affiliation: Department of Neurosurgery, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan. kataoka@med.kindai.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Kataoka
authors.forename: T
authors.initials: T
authors.lastname: Sumii
authors.forename: T
authors.initials: T
authors.lastname: Asai
authors.forename: Y
authors.initials: Y
authors.lastname: Yamada
authors.forename: R
authors.initials: R
authors.lastname: Kuroda
authors.forename: T
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: A
authors.initials: A
authors.lastname: Kinoshita
authors.forename: M
authors.initials: M
authors.lastname: Taneda
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging; D008297:Male; D016634:Radiosurgery / Q000379:methods*; D019292:Skull Base Neoplasms / Q000473:pathology / Q000601:surgery* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin