title: [The reactogenicity and safety of a multicomponent vaccine (VP-4) in the prevention of acute respiratory diseases in preschoolers].
abstract: The reactogenicity and safety of poly-component vaccine (VP-4), prepared from the antigens of opportunistic bacteria, in the prophylaxis of acute respiratory diseases (ARD) in children aged 2.6-6 years. The vaccine was administered intranasally in 3 administrations and orally in 6-8 administrations at intervals of 3-4 days for a period of 24 +/- 4 days. The prophylaxis of ARD with the use of VP-4 was carried out in 168 children in 4 children's preschool institutions. The control group was made up of 120 children, attending the same institutions. The study revealed that VP-4 had low reactogenicity and induced short-time systemic and local reactions (common cold, cough). The administration of VP-4 at a period of the epidemic rise on influenza and ARD morbidity did not lead to an increase in the frequency and duration of ARD in the vaccinees, as well as to the exacerbation of chronic infection and the allergization of the body.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Kurbatova
authors.forename: N B
authors.initials: NB
authors.lastname: Egorova
authors.forename: B F
authors.initials: BF
authors.lastname: Semenov
authors.forename: V N
authors.initials: VN
authors.lastname: Efremova
authors.forename: L A
authors.initials: LA
authors.lastname: Kuz'mina
authors.forename: I M
authors.initials: IM
authors.lastname: Gruber
authors.forename: I B
authors.initials: IB
authors.lastname: Semenova
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Slepoĭ
authors.forename: O P
authors.initials: OP
authors.lastname: Samarina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Volokh
mesh_terms: D000208:Acute Disease; D000281:Administration, Intranasal; D000284:Administration, Oral; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000517:prevention & control*; D012449:Safety; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined