title: Sepsis: the critical role of iron.
abstract: Sepsis is a global problem which is exacerbated by increasing bacterial resistance to antibiotics. However, mechanisms of natural resistance can be extremely effective, and need to be exploited, but the availability of iron is critical for controlling bacterial growth. The diagnosis of sepsis and possible strategies for limiting iron availability are discussed.
authors.affiliation: Department of Surgery, University of Miami School of Medicine, FL 33101, USA.
authors.forename: J
authors.initials: J
authors.lastname: Bullen
authors.forename: E
authors.initials: E
authors.lastname: Griffiths
authors.forename: H
authors.initials: H
authors.lastname: Rogers
authors.forename: G
authors.initials: G
authors.lastname: Ward
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D001770:Blood Bactericidal Activity; D015687:Cell Hypoxia; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism*; D008564:Membrane Potentials; D051379:Mice; D010084:Oxidation-Reduction; D010586:Phagocytes / Q000502:physiology; D018805:Sepsis / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D014168:Transferrin / Q000378:metabolism
chemical_list: D014168:Transferrin; D007501:Iron