[Role of monoaminergic system in the mechanisms of developing a dependence on morphine].
The influence of morphine chronic administration on the neuromediators contents in various structures of brain has been studied. It has been shown that the development of physical dependence on the morphine and abstinence syndrome is accompanied by reduction of activity of serototinergic system, which is manifested in decrease of serotonin and its precursor tryptophane levels. Adrenergic and dophaminergic systems do not react to the development and abstinence by changes of the contents of monoamines that testifies of interaction of opioid and neuromediator systems disturbance.
Filonenko
M A
MA
Institute of Pharmacology and Toxicology of Academy of Medical Science of Ukraine.
Pishel'
V Ia
VIa
Pishel'
I M
IM
Saprykina
N A
NA
D000818:Animals; D015306:Biogenic Monoamines / Q000502:physiology*; D008297:Male; D009021:Morphine Dependence / Q000503:physiopathology*; D051381:Rats
D015306:Biogenic Monoamines