title: Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy.
abstract: Synapsin is a vesicle-associated protein that is thought to be involved in synaptogenesis and neurotransmitter release. In this study, we investigated the repeated amygdala kindling-induced changes in levels of synapsin I, a marker of enhanced synaptic activity, using immunohistochemistry. Eight hours after the last seizure, synapsin I immunoreactivity (IR) was increased bilaterally in the polymorphic zone of the dentate gyrus, the hilus and the stratum lucidum in area CA3 of the hippocampus. However, 4 weeks after the last kindled seizures, synapsin I IR was not significantly changed in any of the brain regions studied. Therefore, the increased levels of synapsin I protein observed in these brain regions early after the last seizure may reflect the plastic changes that occur in the specific neural networks of the hippocampus directly after kindling-induced seizure activity.
authors.affiliation: Department of Neuropsychiatry, Okayama University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Suemaru
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Morimoto
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000679:Amygdala / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism*; D007839:Functional Laterality; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D007696:Kindling, Neurologic / Q000378:metabolism*; D008297:Male; D009473:Neuronal Plasticity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology; D016704:Synapsins / Q000378:metabolism*
chemical_list: D016704:Synapsins