Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva.
Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.
Hall
R
R
Department of Biology, University of York, PO Box 373, York, Y010 5YW, UK.
Boulter
N R
NR
Brown
C G
CG
Wilkie
G
G
Kirvar
E
E
Nene
V
V
Musoke
A J
AJ
Glass
E J
EJ
Morzaria
S P
SP
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000953:Antigens, Protozoan; D002417:Cattle; D007115:Immunization Schedule; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D016796:Theileria annulata / Q000254:growth & development / Q000276:immunology*; D016797:Theileria parva / Q000254:growth & development / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011994:Recombinant Proteins; C114309:p67 antigen, Theileria; C091729:SPAG-1 antigen, Theileria annulata