[Is thrombolytic therapy effective in stroke?].
BACKGROUND
The Norwegian Centre for Health Technology Assessment was asked to assess the treatment of stroke by trombolytic medication. We were also asked to include an evaluation of potential consequences for the organisation of the health care system.


METHODS
Relevant literature was identified on Medline, the Cochrane Library (Systematic Reviews), and INAHTA (Systematic Reviews). Of particular importance are one study from the USA and two studies originating in Europe.


RESULTS
The conclusion of the working group is that the benefit of thrombolytic treatment in the studies assessed is uncertain; furthermore, intracranial haemorrhage can occur as a complication of the treatment.


CONCLUSIONS
Future thrombolytic treatment of stroke patients should be carried out according to a research protocol with thorough documentation of effects as well as side effects.
Mørland
B
B
Senter for medisinsk metodevurdering, SINTEF Unimed, Oslo.
Aarli
J A
JA
Lund
E
E
Myhre
H O
HO
Indredavik
B
B
D018849:Controlled Clinical Trials as Topic; D005060:Europe; D005069:Evaluation Studies as Topic; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000009:adverse effects / Q000379:methods; D016896:Treatment Outcome; D014481:United States