title: [Radiation-induced acne].
abstract: Radiation-induced acne is a rare, clinically and pathogenetically ill-defined acneiform dermatosis with special features that may occur in irradiated skin areas especially after high doses of deeply penetrating radiation. We report on a patient with an oropharyngeal carcinoma who developed severe radiation-induced acne including comedones and cysts as well as few inflammatory papules and pustules in a skin area irradiated with up to 63 gray of a 6 MeV photon beam. Acnegenic drugs may precipitate the disease; our patient was on longterm therapy with carbamazepine whose acnegenic potency is less well documented than that of testosterone or glucocorticoids. Treatment of radiation-induced acne is comedolytic; topical retinoids are especially valuable.
authors.affiliation: Klinik und Poliklinik für Dermatologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin.
authors.forename: C D
authors.initials: CD
authors.lastname: Klemke
authors.forename: S
authors.initials: S
authors.lastname: Nestoris
authors.forename: L U
authors.initials: LU
authors.lastname: Wölfer
authors.forename: S
authors.initials: S
authors.lastname: Krengel
authors.forename: C C
authors.initials: CC
authors.lastname: Zouboulis
authors.forename: B
authors.initials: B
authors.lastname: Tebbe
authors.forename: S
authors.initials: S
authors.lastname: Goerdt
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects; D002220:Carbamazepine / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D005148:Facial Dermatoses / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy; D011855:Radiodermatitis / Q000175:diagnosis; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013577:Syndrome
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine