[Quantitative characteristics of the systemic anaphylaxis model in Sprague-Dawley rats].
Anaphylactic response intensity was quantitatively estimated by means of measuring mean arterial pressure (MAP) and heart rate (HR). Damage to intestinal mucosa was studied by means of morphometry. These indices grew in a dose-dependent way along with the amount of administered egg ovalbumin (OVA). The MAP and HR measurements seem to be useful in a quantitative elucidation of allergic sensitivity in laboratory animals.
Murashev
A N
AN
Subdivision of the Institute of Bioorganic Chemistry of the Russian Acad. Sci., Moscow, Russia.
Korshunov
V A
VA
Khokhlova
O N
ON
Rzhevskiĭ
D I
DI
Gmoshinskiĭ
I V
IV
Lysikov
Iu A
IuA
Mazo
V K
VK
D000707:Anaphylaxis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D000917:Antibody Formation; D001794:Blood Pressure; D002645:Chickens; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
D010047:Ovalbumin