[Participation of the rat caudate nucleus in the immunostimulating effect of DAGO].
The data obtained suggest that administration of the DAGO increased the number of plaque- and rosette-forming cells after immunisation with the sheep red blood cells in the sham-operated Wistar rats. Following destruction of the caudate nucleus, the DAGO administration prevented the immune activation. Bilateral destruction of the caudate nucleus resulted in a considerable inhibition of the immune response as compared with the control rats. Thereupon the caudate nucleus seems to be involved in realisation of the DAGO-induced immune activation.
Devoĭno
L V
LV
Institute of Physiology, Siberian Branch of the Russian Acad. Med. Sci., Novosibirsk, Russia.
Cheĭdo
M A
MA
Al'perina
E L
EL
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000378:metabolism; D002421:Caudate Nucleus / Q000276:immunology*; D004572:Electrolysis; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / Q000494:pharmacology*; D007075:Immunoglobulin M / Q000378:metabolism; D008297:Male; D015213:Neuroimmunomodulation; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000819:agonists; D012397:Rosette Formation
D000276:Adjuvants, Immunologic; D007075:Immunoglobulin M; D017450:Receptors, Opioid, mu; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-