title: Survivorship and radiographic analysis of knee osteoarticular allografts.
abstract: An evaluation of long-term survival and radiographic deterioration of 118 knee osteoarticular allografts in 114 patients was performed. Radiographic analysis was done according to the Musculoskeletal Tumor Society grading system. A failure was defined as when the allograft was removed during a revision procedure or amputation. Ten patients were lost to followup during the first 2 years after surgery. Eighteen patients without allograft failures died of complications related to the tumor. Twenty-six allografts failed because of infection (13 allografts), local recurrence (eight allografts), massive resorptions (three allografts) and fractures (two allografts). Sixty-four allografts still were in place at a mean of 98 months (range, 36-360 months) after implantation. The Kaplan-Meier 5-year survival rate for the knee osteoarticular allografts was 73% and the limb preservation rate was 93%. The mean radiographic score was 83%. Sixty-four percent of the allografts showed no radiologic changes or minor articular deterioration. Fourteen percent had narrowing of the joint space of more than 2 mm, and 22% had some form of subchondral bone collapse. Five patients required joint resurfacing to preserve the original allograft. Most of the allograft failures occurred during the first 4 years, and the allograft survival rate for the current series remained unchanged after 5 years.
authors.affiliation: Institute of Orthopaedics Carlos E. Ottolenghi, Italian Hospital from Buenos Aires, Argentina.
authors.forename: D L
authors.initials: DL
authors.lastname: Muscolo
authors.forename: M A
authors.initials: MA
authors.lastname: Ayerza
authors.forename: L A
authors.initials: LA
authors.lastname: Aponte-Tinao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001175:Arthrography; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D016025:Bone Transplantation; D002648:Child; D002813:Chondrosarcoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D006801:Humans; D007596:Joints / Q000637:transplantation*; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery; D015996:Survival Rate; D014184:Transplantation, Homologous