title: Biomimetic Fe(II)-mediated degradation of arteflene (Ro-42-1611). The first EPR spin-trapping evidence for the previously postulated secondary carbon-centered cyclohexyl radical.
authors.affiliation: Departments of Chemistry and of Pharmacology and Therapeutics, University of Liverpool, P.O. Box 147, Liverpool L69 3BX, U.K.
authors.forename: P M
authors.initials: PM
authors.lastname: O'Neill
authors.forename: L P
authors.initials: LP
authors.lastname: Bishop
authors.forename: N L
authors.initials: NL
authors.lastname: Searle
authors.forename: J L
authors.initials: JL
authors.lastname: Maggs
authors.forename: R C
authors.initials: RC
authors.lastname: Storr
authors.forename: S A
authors.initials: SA
authors.lastname: Ward
authors.forename: B K
authors.initials: BK
authors.lastname: Park
authors.forename: F
authors.initials: F
authors.lastname: Mabbs
mesh_terms: D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D037621:Artemisinins; D001557:Benzenesulfonates; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D003510:Cyclohexanes / Q000737:chemistry / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D005296:Ferrous Compounds / Q000378:metabolism*; D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006418:Heme / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009603:Nitroso Compounds; D010084:Oxidation-Reduction; D010963:Plasmodium falciparum / Q000187:drug effects; D013113:Spin Labels; D013343:Styrenes / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D001557:Benzenesulfonates; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003510:Cyclohexanes; D004365:Drugs, Chinese Herbal; D005296:Ferrous Compounds; D005609:Free Radicals; D009603:Nitroso Compounds; D013113:Spin Labels; D013343:Styrenes; D006418:Heme; C090720:arteflene; C048757:3,5-dibromo-4-nitrosobenzenesulfonate