Acute encephalopathy associated with vigabatrin in a six-month-old girl.
OBJECTIVE
Vigabatrin (VGB) is a new-generation anticonvulsant used in the treatment of partial seizures and West syndrome. Side effects of VGB treatment in adults and children are well described. Acute encephalopathy with VGB has recently been reported in eight adults. They developed stupor, confusion, and electroencephalographic abnormalities after starting VGB. Does the acute encephalopathy with VGB also occur in childhood?


METHODS
We describe a 6-month-old girl with infantile Alexander disease with hydrocephalus who developed similar clinical symptoms with apathia, somnolence, and sopor, as well as slowing of the background activity in EEG, 3 days after starting VGB. After exclusion of shunt dysfunction, encephalitis, metabolic dysfunction, and renal failure, VGB was discontinued.


RESULTS
During the next 2 days, symptoms subsided, and after 10 days, EEG background activity returned to the one before starting VGB.


CONCLUSIONS
Acute encephalopathy associated with VGB in children seems to be very rare, but should not be ignored.
Haas-Lude
K
K
Children's Hospital, University of Tübingen, Tübingen, Germany.
Wolff
M
M
Riethmüller
J
J
Niemann
G
G
Krägeloh-Mann
I
I
D000208:Acute Disease; D000367:Age Factors; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis* / Q000503:physiopathology; D004569:Electroencephalography / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007223:Infant; D013036:Spasms, Infantile / Q000188:drug therapy* / Q000503:physiopathology; D020888:Vigabatrin / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D020888:Vigabatrin