[The characteristics of protein p53 expression in the mucosal epithelium of the large intestine affected by polyps and cancer].
The direct dependence between p53 expression in epithelial cells and the level of morphological malignant neoplasm was established as the result of investigation of expression of this biomolecular marker in 12 polyps and 35 colorectal cancer. It was shown that family cancer syndrome 1 type was observed in pedigrees of majority patients with p53 positive cancers.
Nalieskina
L A
LA
Vorobĭova
L R
LR
Khoma
D I
DI
Polishchuk
L Z
LZ
Oliĭnichenko
H P
HP
Tersenov
Ia O
IaO
Zakhartseva
L M
LM
D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D007420:Intestine, Large / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53