An investigation of the chemical stability of a monomer/polymer gel dosimeter.
The aim of this work is to investigate the temporal stability of a polyacrylamide gelatin hydrogel used for 3D monomer/polymer gel dosimetry techniques involving different methods of analysis. Long-term instabilities for a similar gel have recently been reported, but differ markedly from those described in this work. Two kinds of long-term instabilities are described. One affects the slope of the dose-R2 plot and is related to post-irradiation polymerization of the comonomer/polymer aggregates. It is observed that post-irradiation polymerization only lasts 12 hours after irradiation. The other instability affects the intercept of the dose-R2 plot, lasts for up to 30 days and is related to the gelation process of gelatin. Further studies were performed on gelatin gels of varying compositions to obtain a better understanding of the molecular mechanism that causes the instability due to gelation. The studies included observations of the spin-spin and spin-lattice relaxation rates in combination with diffusion measurements and optical measurements. It is shown that the heating history during the manufacture of the gel affects the absolute R2 value of the gel but not its variation. The findings presented in this study may help in producing more stable and reproducible monomer/polymer gel dosimeters.
De Deene
Y
Y
Radiotherapy and Nuclear Medicine, Ghent University Hospital, Gent, Belgium. yves.dedeene@rug.ac.be
Hanselaer
P
P
De Wagter
C
C
Achten
E
E
De Neve
W
W
D004307:Dose-Response Relationship, Radiation; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods*; D005780:Gelatin / Q000737:chemistry; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D011874:Radiometry / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D013696:Temperature; D013997:Time Factors
D005780:Gelatin