Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: temporal analysis and spatial mapping.
We have noninvasively studied the motor cortex hemodynamics in human subjects under rest and motor stimulation conditions using a multichannel near-infrared tissue spectrometer. Our instrument measures optical maps of the cerebral cortex at two wavelengths (758 and 830 nm), with an acquisition time of 160 ms per map. We obtained optical maps of oxy- and deoxy-hemoglobin concentration changes in terms of amplitudes of folding average, power spectrum and coherence at the stimulation repetition frequency, and the phase synchronization index. Under periodic motor stimulation conditions, we observed coherence and frequency or phase synchronization of the local hemodynamic changes with stimulation. Our main findings are the following: (1) The amplitude of the hemodynamic response to the motor stimulation is comparable to the amplitude of the fluctuations at rest. (2) The spatial patterns of the oxy- and deoxy-hemoglobin responses to the stimulation are different. (3) The hemodynamic response to stimulation shows a spatial localization and a level of phase synchronization with the motor stimulation that depends on the stimulation period.
Toronov
V
V
Department of Physics, University of Illinois at Urbana-Champaign, Urbana 61801-3080, USA. toronov@uiuc.edu
Franceschini
M A
MA
Filiaci
M
M
Fantini
S
S
Wolf
M
M
Michalos
A
A
Gratton
E
E
D000328:Adult; D000368:Aged; D000465:Algorithms; D001921:Brain / Q000098:blood supply*; D007839:Functional Laterality; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D010108:Oxyhemoglobins / Q000378:metabolism; D005082:Physical Exertion; D015203:Reproducibility of Results; D012146:Rest; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin