title: Antisense oligonucleotides as a tool for gene functionalization and target validation.
authors.affiliation: ISIS Pharmaceuticals, Carlsbad, CA 92008, USA. fbennett@isisph.com
authors.forename: C F
authors.initials: CF
authors.lastname: Bennett
authors.forename: L M
authors.initials: LM
authors.lastname: Cowsert
mesh_terms: D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005786:Gene Expression Regulation / Q000187:drug effects; D018390:Gene Targeting / Q000379:methods*; D005796:Genes / Q000502:physiology*; D005820:Genetic Testing / Q000379:methods; D016045:Human Genome Project; D006801:Humans; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA / Q000379:methods; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D013379:Substrate Specificity / Q000235:genetics
chemical_list: D016376:Oligonucleotides, Antisense; D012313:RNA; D011493:Protein Kinase C