[Effects of mifepristone on the serum nitric oxide level and uterine blood flow in early pregnant women].
OBJECTIVE
To study the effects of mifepristone on serum nitric oxide (NO) level and uterine blood flow in early pregnant women.


METHODS
Serum NO concentrations of 58 early pregnant women and 15 normal nonpregnant women were measured by a copper-coated cadmium reduction method, and uterine artery and trophoblastic blood flow were determined by color doppler flow imaging (CDFI). The ultrastructure of villi and decidua were studied under electron microscopy.


RESULTS
Compared with nonpregnant women, serum NO concentration was significantly higher in early pregnant women(P < 0.01). After administration of mifepristone, serum NO level was significantly decreased, resistance index(RI) and systolic to diastolic ratio(S/D) ratio of uterine artery and trophoblastic blood flow were significantly higher than that of normal early pregnancy(P < 0.05).


CONCLUSIONS
Mifepristone may exert effects on uterine blood flow by decreasing serum NO level.
Yang
X
X
First Affiliated Hospital, Hubei Medical University, Wuhan.
Li
M
M
Feng
S
S
D000021:Abortifacient Agents, Steroidal / Q000494:pharmacology*; D000028:Abortion, Induced; D000328:Adult; D005260:Female; D006801:Humans; D015735:Mifepristone / Q000494:pharmacology*; D009569:Nitric Oxide / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012039:Regional Blood Flow; D014599:Uterus / Q000098:blood supply*
D000021:Abortifacient Agents, Steroidal; D009569:Nitric Oxide; D015735:Mifepristone