title: Tumor regression by inductive hyperthermia combined with hepatic embolization using dextran magnetite-incorporated microspheres in rats.
abstract: We formulated a novel preparation of microspheres incorporating dextran magnetite complex (DM-MS), which enable magnetic field-induced heating for the induction of hyperthermia. Using a 500 kHz magnetic field combined with arteriolar embolization of DM-MS, inductive hyperthermia was performed for the treatment of liver tumors in rats. Three days after treatment, the percentage increase of tumor volume in the embolo-hyperthermia, embolization alone, and control groups were 28%, 124%, and 385%, respectively, with the embolo-hyperthermia group differing significantly from the remaining groups. This study demonstrated the feasibility of combining embolization of DM-MS with hyperthermia as an antitumor therapy.
authors.affiliation: Second Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Minamimura
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: S
authors.initials: S
authors.lastname: Kasaoka
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Ishizawa
authors.forename: S
authors.initials: S
authors.lastname: Takemori
authors.forename: K
authors.initials: K
authors.lastname: Tazawa
authors.forename: K
authors.initials: K
authors.lastname: Tsukada
mesh_terms: D000818:Animals; D002279:Carcinoma 256, Walker / Q000628:therapy; D003131:Combined Modality Therapy; D003911:Dextrans / Q000627:therapeutic use*; D004621:Embolization, Therapeutic / Q000379:methods*; D052203:Ferrosoferric Oxide; D006979:Hyperthermia, Induced; D007501:Iron / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D008863:Microspheres; D010087:Oxides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003911:Dextrans; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide