title: Reproductive outcomes in a population exposed long-term to inorganic selenium via drinking water.
abstract: Despite being an essential element in mammals and lower animals at very low doses, selenium is recognized as a teratogen and a growth-inhibiting substance in several animal species. Some inorganic selenium compounds have also been shown to be mutagenic and pro-oxidant: however, very little is known about their effects on human reproduction. Between 1972 and 1988, a few thousand residents in the municipality of Reggio Emilia, northern Italy, were accidentally exposed to drinking water with unusually high levels of inorganic selenium (selenate), range 7-9 microg/l, through a local public water supply system. We found no deleterious effect on overall body weight and length of newborns and stillborns delivered by 18 women previously exposed to high-selenium tapwater. Rates of spontaneous abortions, however, were increased slightly (RR = 1.73; 95% CI = 0.62-4.80), compared with rates among unexposed women from the same municipality. From 1980 through 1988 the prevalence of congenital malformations at birth among the exposed population was similar to that expected, but estimates were imprecise owing to small numbers. Results do not suggest marked effects on human reproduction from chronic exposure to selenate in drinking water at < 10 microg/l.
authors.affiliation: Department of Hygiene, Microbiology and Biostatistics, University of Modena and Reggio Emilia, Italy. vinceti@umino.it
authors.forename: M
authors.initials: M
authors.lastname: Vinceti
authors.forename: C I
authors.initials: CI
authors.lastname: Cann
authors.forename: E
authors.initials: E
authors.lastname: Calzolari
authors.forename: R
authors.initials: R
authors.lastname: Vivoli
authors.forename: L
authors.initials: L
authors.lastname: Garavelli
authors.forename: M
authors.initials: M
authors.lastname: Bergomi
mesh_terms: D000022:Abortion, Spontaneous / Q000139:chemically induced* / Q000453:epidemiology; D000328:Adult; D000013:Congenital Abnormalities / Q000453:epidemiology*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012643:Selenium / Q000009:adverse effects*; D014881:Water Supply
chemical_list: D012643:Selenium