title: Two antinematodal phenolics from Knema hookeriana, a Sumatran rainforest plant.
abstract: The activity-guided chromatographic purification of the methanol extract of Knema hookeriana, using pine wood nematodes Bursaphelenchus xylophilus has successfully led to the isolation and characterization of two phenolic antinematodal compounds with minimum effective dose (MED) of 4.5 and 20 microg/cotton ball (microg/bl.) or 0.018 and 0.073 microM/cotton ball (microM/bl.), respectively. Based on their chemical and spectral properties, these compounds were determined to be 3-undecylphenol (1) and 3-(8Z-tridecenyl)-phenol (2). These compounds were isolated for the first time from this species, and 2 seems to be a novel compound.
authors.affiliation: The Graduate School of Natural Science and Technology, Department of Applied Bioscience and Biotechnology, Okayama University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Alen
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Nitoda
authors.forename: N
authors.initials: N
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Kanzaki
authors.forename: K
authors.initials: K
authors.lastname: Kawazu
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000494:pharmacology*; D009348:Nematoda / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D010944:Plants / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000871:Anthelmintics; D010636:Phenols