[Determination of cellular and humoral immunity in mice of autoimmune ovarian failure].
OBJECTIVE
To determine cellular and humoral immunity in mice of autoimmune ovarian failure.


METHODS
A mice model of autoimmune ovarian failure was established. The percentages of help T cell (CD4+) and suppressor T cell (CD8+), the ratio of CD4/CD8 and anti-ovarian antibody (AOA) were determined.


RESULTS
No significant changes were found in CD4+ fraction, but the percentage of CD8+ was reduced and the ratio of CD4/CD8 increased. AOA was positive which was probably the cause of damage of the ovarian tissues, reduction of sex hormone secretion and impaired fertility.


CONCLUSIONS
Autoimmune ovarian failure is correlated with the abnormal change of CD4/CD8 and the increase of B-lymphocytes function.
Lin
J
J
Renji Hospital, Shanghai Second Medical University.
Yan
J
J
Lin
Q
Q
D000818:Animals; D000917:Antibody Formation; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D016516:CD4-CD8 Ratio; D005260:Female; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D010053:Ovary / Q000276:immunology; D016649:Primary Ovarian Insufficiency / Q000276:immunology*
D001323:Autoantibodies