Antimitotic diterpenes from Erythropodium caribaeorum test pharmacophore models for microtubule stabilization.
[structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.
Cinel
B
B
Department of Chemistry, University of British Columbia, Vancouver, Canada.
Roberge
M
M
Behrisch
H
H
van Ofwegen
L
L
Castro
C B
CB
Andersen
R J
RJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D002453:Cell Cycle / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008870:Microtubules / Q000737:chemistry*; D008958:Models, Molecular; D013329:Structure-Activity Relationship
D000470:Alkaloids; D000970:Antineoplastic Agents; D004224:Diterpenes; C109551:eleutherobin