title: In and out of the postsynaptic region: signalling proteins on the move.
abstract: Reversible translocation of signalling proteins to and from their sites of action has emerged as an important theme in signal transduction. The recent findings of the stimulus-induced translocation of Ca2+-calmodulin-dependent protein kinase II (CaMKII) and the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor to and from the postsynaptic region are model cases for understanding how the dynamic localization of signalling proteins is used to regulate signal transduction.
authors.affiliation: Dept of Molecular Pharmacology, Stanford University School of Medicine, CA 94305, USA.
authors.forename: T
authors.initials: T
authors.lastname: Meyer
authors.forename: K
authors.initials: K
authors.lastname: Shen
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D009474:Neurons / Q000737:chemistry / Q000201:enzymology*; D018091:Receptors, AMPA / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000737:chemistry / Q000201:enzymology*
chemical_list: D018091:Receptors, AMPA; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017871:Calcium-Calmodulin-Dependent Protein Kinases