Vitamin E: non-antioxidant roles.
Vitamin E was originally considered a dietary factor of animal nutrition especially important for normal reproduction. The significance of vitamin E has been subsequently proven as a radical chain breaking antioxidant that can protect the integrity of tissues and play an important role in life processes. More recently alpha-tocopherol has been found to possess functions that are independent of its antioxidant/radical scavenging ability. Absorption in the body is alpha-tocopherol selective and other tocopherols are not absorbed or are absorbed to a lesser extent. Furthermore, pro-oxidant effects have been attributed to tocopherols as well as an anti-nitrating action. Non-antioxidant and non-pro-oxidant molecular mechanisms of tocopherols have been also described that are produced by alpha-tocopherol and not by beta-tocopherol. alpha-Tocopherol specific inhibitory effects have been seen on protein kinase C, on the growth of certain cells and on the transcription of some genes (CD36, and collagenase). Activation events have been seen on the protein phosphatase PP2A and on the expression of other genes (alpha-tropomyosin and Connective Tissue Growth Factor). Non-antioxidant molecular mechanisms have been also described for gamma-tocopherol, delta-tocopherol and tocotrienols.
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Institute of Biochemistry and Molecular Biology, Bühlstrasse 28, 3012 Bern (Switzerland) University of Bern, Bern, Switzerland. angelo.azzi@mci.unibe.ch
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D000975:Antioxidants; D006801:Humans; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D014810:Vitamin E / Q000737:chemistry / Q000493:pharmacokinetics / Q000502:physiology*; D014811:Vitamin E Deficiency / Q000150:complications
D000975:Antioxidants; D014810:Vitamin E; D011493:Protein Kinase C