title: Polymorphisms in GSTM1, GSTT1 and CYP1A1 and risk of pancreatic adenocarcinoma.
abstract: A prospective study of 149 unselected incident cases of pancreatic adenocarcinoma and 146 ethnically-matched controls found no associations between GSTM1 (adjusted odds ratio (AOR) 1.14), GSTT1 (AOR: 1.19) and CYP1A1 (AOR: 1.08) polymorphisms and pancreatic cancer susceptibility. Smoking and drinking status did not affect results. These polymorphisms do not appear to be important gene modifiers in pancreatic cancer.
authors.affiliation: Centre for Research in Women's Health, Women's College Hospital, University of Toronto, Canada.
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: P
authors.initials: P
authors.lastname: Ghadirian
authors.forename: D
authors.initials: D
authors.lastname: Vesprini
authors.forename: N
authors.initials: N
authors.lastname: Hamel
authors.forename: A J
authors.initials: AJ
authors.lastname: Paradis
authors.forename: G
authors.initials: G
authors.lastname: Lal
authors.forename: S
authors.initials: S
authors.lastname: Gallinger
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
authors.forename: W D
authors.initials: WD
authors.lastname: Foulkes
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012044:Regression Analysis; D012306:Risk
chemical_list: D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1