title: Haemodynamic depression by halothane is age-related in paediatric patients.
abstract: The hypothesis that young infants are more sensitive to the haemodynamic depressant effects of halothane compared with older children was tested. One hundred and sixty unpremedicated, ASA physical status I or II paediatric patients without cardiac or pulmonary disease were divided into five age groups: term neonates, 1-6 months, 6-24 months, 2-6 years and 6-12 years. Anaesthetic induction was achieved with halothane in oxygen and air via mask. Vecuronium 0.1 mg.kg-1 was administered intravenously. During normocapnic manual ventilation by mask, endtidal halothane concentration was maintained at either 2xage-specific MAC (Method I) or 1.7% (Method II) in 20 patients in each age group for 10 min. In both Method I and Method II, systolic and mean blood pressure of term neonates and infants aged 1-6 months decreased significantly (P < 0.01) compared with other age groups. The results of this study demonstrate that neonates and young infants are more susceptible to haemodynamic depression during halothane anaesthesia than are older children, confirming clinical experience.
authors.affiliation: Department of Anesthesiology, The Children's Hospital and the University of Colorado School of Medicine, Denver, Colorado, USA.
authors.forename: R H
authors.initials: RH
authors.lastname: Friesen
authors.forename: J L
authors.initials: JL
authors.lastname: Wurl
authors.forename: G A
authors.initials: GA
authors.lastname: Charlton
mesh_terms: D000367:Age Factors; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D017558:Elective Surgical Procedures; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn
chemical_list: D018685:Anesthetics, Inhalation; D006221:Halothane