title: [Quantitative characteristics of the systemic anaphylaxis model in Sprague-Dawley rats].
abstract: Anaphylactic response intensity was quantitatively estimated by means of measuring mean arterial pressure (MAP) and heart rate (HR). Damage to intestinal mucosa was studied by means of morphometry. These indices grew in a dose-dependent way along with the amount of administered egg ovalbumin (OVA). The MAP and HR measurements seem to be useful in a quantitative elucidation of allergic sensitivity in laboratory animals.
authors.affiliation: Subdivision of the Institute of Bioorganic Chemistry of the Russian Acad. Sci., Moscow, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Murashev
authors.forename: V A
authors.initials: VA
authors.lastname: Korshunov
authors.forename: O N
authors.initials: ON
authors.lastname: Khokhlova
authors.forename: D I
authors.initials: DI
authors.lastname: Rzhevskiĭ
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinskiĭ
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Lysikov
authors.forename: V K
authors.initials: VK
authors.lastname: Mazo
mesh_terms: D000707:Anaphylaxis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D000917:Antibody Formation; D001794:Blood Pressure; D002645:Chickens; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010047:Ovalbumin