Role of antioxidant enzymes in brain tumours.
Erythrocyte antioxidant enzymes were analysed in 100 patients with intracranial neoplasm and in 47 controls. There was a significant decrease in RBC glutathione reductase (GRx) and superoxide dismutase (SOD) activity in most types of brain tumor cases. Patients with acoustic neurinoma showed a significant reduction in selenium-dependent glutathione peroxidase (Se-GPx) activity. A decrease in catalase (CT) activity was seen in most of the brain tumor patients but remained statistically insignificant when compared to controls. A significant increase in plasma ceruloplasmin concentration was observed in patients with glioma. These enzymes were also studied in 27 post-treatment cases. GRx activity returned to normal levels in these patients. RBC SOD and plasma ceruloplasmin levels showed a tendency to return to normal. Hence, a marked decrease in the antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with brain tumors.
Rao
G M
GM
Department of Biochemistry, Kasturba Medical College, Mangalore, India.
Rao
A V
AV
Raja
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Rao
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Rao
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000378:metabolism*; D001932:Brain Neoplasms / Q000201:enzymology*; D002374:Catalase / Q000097:blood; D002570:Ceruloplasmin / Q000032:analysis; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005910:Glioma / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008297:Male; D008579:Meningioma / Q000201:enzymology; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000201:enzymology; D012643:Selenium / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005980:Glutathione Reductase; D012643:Selenium