title: Hemodynamic changes and right heart support during vertical displacement of the beating heart.
abstract: BACKGROUND
  Hemodynamic instability during heart displacement in off-pump multivessel coronary artery bypass grafting might be related to right heart dysfunction. The Enabler (HemoDynamics Systems Ltd, Upper Yoqneam, Israel) is a cannula pump that expels blood from the right atrium into the pulmonary artery. We studied the hemodynamic changes and the role of the enabler during heart displacement.
  
  
  METHODS
  Nine anesthetized sheep were assessed for hemodynamic changes during 90-degree heart displacement with or without Enabler support. Hemodynamic parameters included cardiac output, systemic arterial blood pressures, and left and right heart filling pressures.
  
  
  RESULTS
  Heart displacement caused a significant decrease in cardiac output and systemic blood pressure (46%+/-5%, p = 0.001; and 20%+/-5%, p = 0.009, respectively), with a concomitant 137%+/-24% (p = 0.003) increase in central venous pressure. No significant change in left atrial pressure was observed. Activation of the Enabler caused a significant increase in cardiac output and systemic blood pressure (67%+/-15%, p = 0.01; and 17%+/-7%, p = 0.04, respectively), as well as a decrease in central venous pressure by 49%+/-8% (p = 0.0001).
  
  
  CONCLUSIONS
  Heart displacement causes hemodynamic instability mainly by right heart dysfunction. The Enabler significantly stabilized circulation during vertical displacement of the beating heart.
authors.affiliation: Department of Cardiothoracic Surgery, Carmel Medical Center, Technion IIT, Haifa, Israel. docporat@internet-zahav.net
authors.forename: E
authors.initials: E
authors.lastname: Porat
authors.forename: R
authors.initials: R
authors.lastname: Sharony
authors.forename: S
authors.initials: S
authors.lastname: Ivry
authors.forename: S
authors.initials: S
authors.lastname: Ozaki
authors.forename: B P
authors.initials: BP
authors.lastname: Meyns
authors.forename: W J
authors.initials: WJ
authors.lastname: Flameng
authors.forename: G
authors.initials: G
authors.lastname: Uretzky
mesh_terms: D000818:Animals; D016280:Atrial Function, Right; D002302:Cardiac Output; D006353:Heart-Assist Devices; D006439:Hemodynamics; D012756:Sheep