[Effects of the chronic malnutrition on the transferrin receptors in patients with nutritional anemia].
It has been postulated that the provision of iron to the erythroid cells is under the control of a fraction of free intracellular iron. Variations in the size of this pool would send messages to either seric or cellular iron receptors aimed to keep a balance between the offer and the demand by the cells. The possibility that cell membrane receptors could be affected by chronic malnutrition was explored in these studies by the changes of iron uptake capacity of circulating mouse reticulocytes cause by the incubation of the cells with serum of either normal or anemic patients plasma donors. The results show that the incubation with nutritional anemic serum caused a significant drop in iron uptake capacity of the cells. The mechanism of the difference is discussed.
Miranda
C E
CE
Dpto. Erital-Instituto de Biología de la Altura, Universidad Nacional de Jujuy, San Salvador de Jujuy, Argentina.
Scaro
L
L
Torrejon
I
I
Buys
M C
MC
Martin
B
B
Guerra
L
L
D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000209:etiology / Q000378:metabolism*; D000818:Animals; D002648:Child; D002908:Chronic Disease; D006801:Humans; D007501:Iron / Q000378:metabolism*; D051379:Mice; D011502:Protein-Energy Malnutrition / Q000150:complications / Q000378:metabolism*; D011990:Receptors, Transferrin / Q000378:metabolism*; D012156:Reticulocytes / Q000378:metabolism*
D011990:Receptors, Transferrin; D007501:Iron