Organic synthesis using chemical tags: the third Leg of parallel synthesis.
Increasing emphasis has recently been placed on the development of synthetic methods which effectively couple chemical synthesis and purification. For example, new formats for parallel synthesis are being developed which involve attachment of chemical tags to both reagents, reactants, and substrates to permit their chemoselective removal from reaction mixtures. The driving force for the development of tagged organic reagents is the ability to use standard solution-phase chemistry methods and reaction monitoring techniques (e.g. TLC and HPLC). In this mini-review, we will outline recent developments on the growing class of chemically tagged reagents, reactants, and substrates and highlight examples of their use in multistep synthesis.
Porco
J A
JA
Department of Chemistry and Center for Streamlined Synthesis, Metcalf Center for Science and Engineering, Boston University, MA 02215, USA. porco@chem.bu.edu
D002846:Chromatography, Affinity / Q000379:methods; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007202:Indicators and Reagents / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*; D012116:Resins, Plant
D007202:Indicators and Reagents; D011108:Polymers; D012116:Resins, Plant