An efficient synthesis of pyrimidines from beta-amino alcohols.
[reaction: see text] Pyrimidinones 3 were chemoselectively reduced by using metal-catalyzed hydrogenation and stereoselectively substituted by various nucleophiles. Starting from beta-amino alcohols 1, the overall process allows efficient access to substituted pyrimidines 4 and 6.
Agami
C
C
Laboratoire de Synthèse Asymétrique UMR 7611, Université P. et M. Curie, Paris, France.
Dechoux
L
L
Melaimi
M
M
D000605:Amino Alcohols / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis*
D000605:Amino Alcohols; D011743:Pyrimidines