Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin.
Streptomyces hygroscopicus ATCC 29253 produces rapamycin, elaiophylin and nigericin. Although elaiophylin has no activity against Candida albicans ATCC 11651, it markedly enhances rapamycin's antifungal activity. Nigericin has only weak activity on its own but it also enhances rapamycin action. Surprisingly, elaiophylin does not enhance nigericin activity on C. albicans.
Fang
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A
Biology Department, Massachusetts Institute of Technology, Cambridge 02139, USA.
Wong
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GK
Demain
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D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D020128:Inhibitory Concentration 50; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009550:Nigericin / Q000378:metabolism / Q000494:pharmacology*; D020123:Sirolimus / Q000378:metabolism / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C033279:elaiophylin; D009550:Nigericin; D020123:Sirolimus