title: Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue.
abstract: The present study sought to determine how usage of coreceptors by human immunodeficiency virus type 1 dictates cell tropism and depletion of CD4(+) T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expressing CD4(+) lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.
authors.affiliation: Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Grivel
authors.forename: M L
authors.initials: ML
authors.lastname: Penn
authors.forename: D A
authors.initials: DA
authors.lastname: Eckstein
authors.forename: B
authors.initials: B
authors.lastname: Schramm
authors.forename: R F
authors.initials: RF
authors.lastname: Speck
authors.forename: N W
authors.initials: NW
authors.lastname: Abbey
authors.forename: B
authors.initials: B
authors.lastname: Herndier
authors.forename: L
authors.initials: L
authors.lastname: Margolis
authors.forename: M A
authors.initials: MA
authors.lastname: Goldsmith
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism* / Q000821:virology; D015497:HIV-1 / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008212:Lymphocyte Depletion; D008221:Lymphoid Tissue / Q000166:cytology; D019713:Receptors, CCR5 / Q000378:metabolism*; D019718:Receptors, CXCR4 / Q000378:metabolism*
chemical_list: D019713:Receptors, CCR5; D019718:Receptors, CXCR4