Synthesis of multiply substituted, ion channel forming octi(p-phenylene)s: theme and variations.
[reaction: see text] To facilitate the access to unique models for biological processes, we examined six different synthetic routes to octi(p-phenylene) rods with lateral and terminal substituents R(L) and R(T). This systematic study allowed us to increase to overall yield for the synthesis of a new class of oligo(p-phenylene) ionophores about 20 times and to provide general insights into the practicability of synthetic routes to multiply substituted molecular rods.
Robert
F
F
Department of Organic Chemistry, University of Geneva, Switzerland.
Winum
J Y
JY
Sakai
N
N
Gerard
D
D
Matile
S
S
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000627:therapeutic use; D002462:Cell Membrane / Q000187:drug effects*; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000627:therapeutic use; D007473:Ion Channels / Q000378:metabolism
D000890:Anti-Infective Agents; D004988:Ethers, Cyclic; D007473:Ion Channels