Dynamic kinetic resolution of alpha-hydroxy acid esters
[formula: see text] Enzymatic resolution in combination with ruthenium-catalyzed racemization of the substrate led to dynamic kinetic resolution of alpha-hydroxy esters in good yields and excellent ee's. Studies of different parameters showed that the best results were obtained using Pseudomonas cepacia lipase, ruthenium catalyst 3, and 4-chlorophenyl acetate as acyl donor in cyclohexane.
Huerta
FF
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden.
Laxmi
YR
Backvall
JE