Cyclic AMP and fluconazole resistance in Saccharomyces cerevisiae.
Cyclic AMP (cAMP) is involved in the stress response in Saccharomyces cerevisiae. We show that cAMP is required for resistance to fluconazole in S. cerevisiae. In addition, activation of Ras2, a regulator of cAMP generation, results in some protection from fluconazole toxicity in a fashion independent of the efflux transporter Pdr5p.
Kontoyiannis
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DP
Department of Internal Medicine Specialties, Section of Infectious Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA. dkontoyi@notes.mdacc.tmc.edu
Rupp
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D000935:Antifungal Agents / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism*
D000935:Antifungal Agents; D015725:Fluconazole; D000242:Cyclic AMP