[The expression of integrin beta 3 in cycling and early pregnant endometrium and its relationship with primary unexplained infertility].
OBJECTIVE
To profile the changes in integrin beta 3 expression in cycling and early pregnant endometrium and its relationship with unexplained infertility.


METHODS
Expression of integrin beta 3 on endometrium was detected in 56 normal cycling women during different menstrual phases or early pregnant women, and 9 cases with unexplained infertility during mid-luteal phase by immunohistochemistry technique.


RESULTS
Integrin beta 3 was expressed only in the midluteal or pregnant endometrium(after cycle day 19). Compared with normal women, integrin beta 3 failed to express in the midluteal endometrium from women with unexplained infertility.


CONCLUSIONS
Our findings suggest integrin beta 3 may play important roles in the process of implantation and decidualization. It might be a new reliable marker of uterine receptivity. Abnormal endometrial integrin beta 3 expression might be the major cause of unexplained infertility.
Chen
D
D
Nanfang Hospital, First Military Medical University, Guangzhou.
Jin
Z
Z
Xing
F
F
D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis*; D003656:Decidua / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism*; D039661:Integrin beta3; D008183:Luteal Phase; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D015703:Antigens, CD; D039661:Integrin beta3; D010980:Platelet Membrane Glycoproteins