title: Intubation conditions and postoperative myalgia in outpatient dental surgery: a comparison of succinylcholine with mivacurium.
abstract: Ninety-four patients undergoing elective outpatient third molar extraction were recruited into a double-blind, randomized, prospective trial comparing mivacurium (group M) with succinylcholine (Group S) for conditions for endotracheal intubation and the occurrence of postoperative myalgia. Anaesthesia was induced with fentanyl 1 microgram.kg-1 and propofol 2.5 micrograms.kg-1 in all patients. Group S patients were given gallamine 20 mg while group M patients were given mivacurium 0.2 mg.kg-1. Manual ventilation was commenced and anaesthesia maintained with nitrous oxide 70% and isoflurane 1 to 2% in oxygen. After two minutes, group S patients were given succinylcholine 1.5 mg.kg-1 and group M patients 0.9% saline. Nasotracheal intubation was performed 30 seconds later. Intubating conditions in group M were significantly better than those in group S (P < 0.001). The incidence of postoperative myalgia was 9.5% in group M and 26% in group S but this was not statistically significant (P = 0.09). We propose that mivacurium is a suitable neuromuscular blocker to use for endotracheal intubation in outpatient dental surgery.
authors.affiliation: Department of Anaesthetics, St John's Hospital at Howden, Livingston, West Lothian, U.K.
authors.forename: S
authors.initials: S
authors.lastname: Deehan
authors.forename: D
authors.initials: D
authors.lastname: Henderson
authors.forename: K
authors.initials: K
authors.lastname: Stewart
mesh_terms: D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000766:Anesthesia, Dental; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007442:Intubation, Intratracheal; D007546:Isoquinolines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D000077590:Mivacurium; D008964:Molar, Third; D009135:Muscular Diseases / Q000139:chemically induced*; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D010149:Postoperative Pain / Q000139:chemically induced*; D011446:Prospective Studies; D013390:Succinylcholine / Q000009:adverse effects*; D014081:Tooth Extraction
chemical_list: D007546:Isoquinolines; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D013390:Succinylcholine