title: The development of the stria vascularis in the human foetus.
abstract: The development of the stria vascularis in the human cochlea was studied in step sections of 81 human foetal temporal bones. The stria vascularis primordium can be identified as a ridge of epithelial cells on the lateral wall of the cochlear duct. The first signs of differentiation appear at the 11th week, but it is not until the 17th-18th week that the typical trilaminar structure is observed. The appearance of similar cells with notched nuclei in both marginal and mesenchymal layers at this stage suggests the possibility that some of the intermediate cells may be of epithelial origin. By the 21st week, the overall appearance resembles that of the adult structure. This occurs 1 week after the opening of the tunnel of Corti, and possibly marks the onset of cochlear function.
authors.affiliation: Institute of Laryngology and Otology, Royal Free and University College London Medical School, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Bibas
authors.forename: J
authors.initials: J
authors.lastname: Liang
authors.forename: L
authors.initials: L
authors.lastname: Michaels
authors.forename: A
authors.initials: A
authors.lastname: Wright
mesh_terms: D003053:Cochlear Duct / Q000166:cytology / Q000196:embryology*; D005314:Embryonic and Fetal Development / Q000502:physiology; D005865:Gestational Age; D006801:Humans; D013316:Stria Vascularis / Q000166:cytology*; D013701:Temporal Bone / Q000196:embryology