Can cord blood cells support the cytokine storm in GvHD?
Cord blood has a high number of proliferating hematopoietic progenitors and is therefore used as an alternative source of hematopoietic cells for allogeneic transplantation. In addition there is a wider availability of cord blood and a lower cost of procurement compared to bone marrow. However one of the most interesting immunological benefits of a cord blood transplant that has been proposed is the low severity of Graft versus Host Disease (GvHD). This review aims to address some of the immunological reasons why this may be the case by assessing the role of cord blood cytokines in the cytokine storm of GvHD.
Cohen
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SB
The Anthony Nolan Research Institute, The Royal Free Hospital, Pond Street, Hampstead, London, UK. sharacohen@bigfoot.com
Wang
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XN
Dickinson
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A
D000818:Animals; D016207:Cytokines / Q000276:immunology* / Q000494:pharmacology; D005312:Fetal Blood / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D006086:Graft vs Host Disease / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D018121:Receptors, Cytokine / Q000097:blood; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D018121:Receptors, Cytokine