title: Ovarian leiomyosarcoma: an autopsy case report.
abstract: Primary non-specific sarcoma of the ovary is extremely rare, and only 22 reported cases of pure leiomyosarcoma (LMS) are known to the authors. We present an autopsy case of a primary ovarian leiomyosarcoma in a 73-year-old woman. She had noticed an abdominal mass after difficulty in defecating for several months. The excision of tumor with bilateral salpingo-oophorectomy and hysterectomy was carried out. A diagnosis of pure leiomyosarcoma of the left ovary was made on pathological examination with immunohistochemistry. Adjuvant radio-chemotherapy was not given. At 18 months' follow up, abdomino-pelvic sonography revealed an abdominal tumor and hepatic metastasis. The patient died 3.5 years after the initial surgery. The post-mortem examination revealed a peritoneal recurrent tumor and extensive distant metastases of the liver, lungs, pancreas, gastric mucosa, muscle and skin. The prognosis of the ovarian LMS is poor from the pertinent literature. Several prognostic indicators on histology including mitotic activity, proliferative activity and p53 status of the tumor are discussed.
authors.affiliation: Departments of Pathology and; Obstetrics and Gynecology, International Medical Center of Japan, Tokyo.
authors.forename: M
authors.initials: M
authors.lastname: Nasu
authors.forename: J
authors.initials: J
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Matsui
authors.forename: S
authors.initials: S
authors.lastname: Minoura
authors.forename: O
authors.initials: O
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000556:secondary* / Q000601:surgery; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery