title: Salmonella enterica serovars Typhimurium and Dublin can lyse macrophages by a mechanism distinct from apoptosis.
abstract: Salmonella enterica serovars Typhimurium and Dublin lysed primary bovine alveolar macrophages and immortalized J774.2 macrophage-like cells in the absence of either the morphological changes or DNA fragmentation characteristic of apoptosis. Macrophage lysis was dependent on a subset of caspases and an intact sipB gene.
authors.affiliation: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom.
authors.forename: P R
authors.initials: PR
authors.lastname: Watson
authors.forename: A V
authors.initials: AV
authors.lastname: Gautier
authors.forename: S M
authors.initials: SM
authors.lastname: Paulin
authors.forename: A P
authors.initials: AP
authors.lastname: Bland
authors.forename: P W
authors.initials: PW
authors.lastname: Jones
authors.forename: T S
authors.initials: TS
authors.lastname: Wallis
mesh_terms: D000818:Animals; D017209:Apoptosis; D001426:Bacterial Proteins / Q000235:genetics; D061945:Caspase Inhibitors; D002417:Cattle; D016923:Cell Death; D005057:Eukaryotic Cells; D016676:Macrophages, Alveolar / Q000382:microbiology* / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics; D019779:Salmonella enterica / Q000472:pathogenicity*; D012486:Salmonella typhimurium / Q000472:pathogenicity*
chemical_list: D001426:Bacterial Proteins; D061945:Caspase Inhibitors; D008565:Membrane Proteins; C094579:invasion protein B, Salmonella typhimurium