title: Total synthesis of (-)-reveromycin B.
abstract: [structure: see text] The total synthesis of the epidermal growth factor inhibitor reveromycin B (2) is described. A novel, convergent, and stereoselective reaction sequence was utilized to construct the 5,6-spiroketal system 10 which was converted into the natural product 2 by a 16-step sequence.
authors.affiliation: School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia.
authors.forename: A N
authors.initials: AN
authors.lastname: Cuzzupe
authors.forename: C A
authors.initials: CA
authors.lastname: Hutton
authors.forename: M J
authors.initials: MJ
authors.lastname: Lilly
authors.forename: R K
authors.initials: RK
authors.lastname: Mann
authors.forename: M A
authors.initials: MA
authors.lastname: Rizzacasa
authors.forename: S C
authors.initials: SC
authors.lastname: Zammit
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors; D011714:Pyrans / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D011714:Pyrans; D013141:Spiro Compounds; C409389:reveromycin B; D004815:Epidermal Growth Factor