title: Insidious destruction of the hip by Mycobacterium tuberculosis and why early diagnosis is critical.
abstract: Tuberculosis has re-emerged as an important problem in the United States. More than 10 million people presently are infected with Mycobacterium tuberculosis in the United States alone. The symptoms at first presentation of the disease have become more diverse. With extrapulmonary manifestations, such as musculoskeletal infections, as the sole presenting sign, it often can be difficult to determine the correct diagnosis early in the course of the disease. The presenting symptoms, physical signs, and radiographic findings of intra-articular tuberculosis can mimic those of other intra-articular diseases, such as rheumatoid arthritis, osteoarthritis, and avascular necrosis. In view of the nonspecific findings early in course of the disease, tubercular infection should be considered in the differential diagnosis when there is insidious articular destruction. Failure to consider tuberculosis can lead to devastating outcomes otherwise preventable with today's chemotherapies.
authors.affiliation: Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, Philadelphia, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Silber
authors.forename: S B
authors.initials: SB
authors.lastname: Whitfield
authors.forename: K
authors.initials: K
authors.lastname: Anbari
authors.forename: J
authors.initials: J
authors.lastname: Vergillio
authors.forename: F
authors.initials: F
authors.lastname: Gannon
authors.forename: R H
authors.initials: RH
authors.lastname: Fitzgerald
mesh_terms: D000077:Acetabulum / Q000382:microbiology / Q000473:pathology*; D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D003646:Debridement; D005270:Femur Head / Q000382:microbiology / Q000473:pathology*; D005272:Femur Neck / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008297:Male; D009336:Necrosis; D011859:Radiography; D012598:Sclerosis; D014394:Tuberculosis, Osteoarticular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*