[Effects of propofol and etomidate on cerebral oxygen supply and demand balance during middle hypothermia cardiopulmonary bypass].
Effects of propofol(Group P) and etomidate(Group E) on cerebral oxygen supply and demand balance during middle hypothermia cardiopulmonary bypass(CPB) were studied in twenty patients undergoing cardiac valve replacement. Arterial blood and jugular bulb blood were taken to analyse blood gas, and cerebral oxygen content were caculated.


RESULTS
During hypothermia, jugular bulb oxygen saturation(SjO2), jugular bulb blood oxygen content(CjO2) increased; cerebral oxygen extraction rate(CEO2) decreased significantly in two groups(P < 0.05). During rewarming SjO2, CjO2 were significantly decreased, CEO2 increased compared with that before rewarming and hypothermia in two gbroups (P < 0.05). In Group P, SjO2 and CjO2 were higher, CEO2 lower than those in Group E respectively during rewarming (P < 0.05). CONCULUSION: The activity of propofol reduced cerebral metabolism, cerebral oxygen consumption and CEO2 is better than that of etomidate.
Zhou
J
J
Department of Anesthesiology, Second Affiliated Hospital, Hunan Medical University, Changsha.
Liu
L
L
Chen
Q
Q
D000328:Adult; D018686:Anesthetics, Intravenous; D001784:Blood Gas Analysis; D001921:Brain / Q000378:metabolism*; D002315:Cardiopulmonary Bypass; D005045:Etomidate; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D015742:Propofol
D018686:Anesthetics, Intravenous; D015742:Propofol; D005045:Etomidate