Development of apomorphine-induced aggressive behavior: comparison of adult male and female Wistar rats.
The development of apomorphine-induced (1.0 mg/kg s.c. once daily) aggressive behavior of adult male and female Wistar rats obtained from the same breeder was studied in two consecutive sets. In male animals, repeated apomorphine treatment induced a gradual development of aggressive behavior as evidenced by the increased intensity of aggressiveness and shortened latency before the first attack toward the opponent. In female rats, only a weak tendency toward aggressiveness was found. In conclusion, the present study demonstrates gender differences in the development of the apomorphine-induced aggressive behavior and indicates that the female rats do not fill the validation criteria for use in this method.
Pruus
K
K
Department of Pharmacology, University of Tartu, Estonia.
Rudissaar
R
R
Skrebuhhova-Malmros
T
T
Allikmets
L
L
Matto
V
V
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics
D018491:Dopamine Agonists; D001058:Apomorphine