Internal structure of the chromatin subunit.
The digestion of chromatin insitu with DNase I reveals, after denaturation, a regular series of single stranded DNA fragments the lengths of which represent multiples of 10 bases. These experiments are compatible with the DNA being on the outside of the chromatin subunit and suggest that the subunit structure itself contains repetitive structural elements. Possible models are discussed.
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D000818:Animals; D004247:DNA / Q000737:chemistry; D003850:Deoxyribonuclease I / Q000494:pharmacology; D008099:Liver / Q000737:chemistry / Q000648:ultrastructure; D008954:Models, Biological; D009691:Nucleic Acid Denaturation; D009707:Nucleosomes / Q000187:drug effects / Q000648:ultrastructure*; D011489:Protein Denaturation; D051381:Rats
D009707:Nucleosomes; D004247:DNA; D003850:Deoxyribonuclease I