Inhibitory effect of a cyclic urea derivative on rubella virus replication.
1-(4-Morpholinomethyl)-tetrahydro-2(1H)-pyrimidinone (mopyridone) exhibited a marked activity against rubella virus (Judith and RA27/3 strains), a MIC50 value of 0.9 microM and selectivity ratio of 557.7 been found in the case of Judith strain. These data, in addition to the previous ones about its anti-alphavirus effects suggest the compound to be considered as a broad spectrum inhibitor of togavirus replication.
Galabov
A S
AS
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia. galabov@microbio.bas.bg
Mihneva
Z
Z
Hadjiathanassova
V
V
Zhukovec
V
V
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D006224:Cricetinae; D011744:Pyrimidinones / Q000494:pharmacology*; D012412:Rubella virus / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011744:Pyrimidinones; C047314:1-morpholinomethyl-tetrahydro-1(1H)-pyrimidinone