Antibody is required for protection against virulent but not attenuated Salmonella enterica serovar typhimurium.
Resolution of infection with attenuated Salmonella is an active process that requires CD4(+) T cells. Here, we demonstrate that costimulation via the surface molecule CD28, but not antibody production by B cells, is required for clearance of attenuated aroA Salmonella enterica serovar typhimurium. In contrast, specific antibody is critical for vaccine-induced protection against virulent bacteria. Therefore, CD28(+) CD4(+) T cells are sufficient for clearance of avirulent Salmonella in naive hosts, whereas CD4(+) T cells and specific antibodies are required for protection from virulent Salmonella in immune hosts.
McSorley
S J
SJ
Department of Microbiology and Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. mcsor001@tc.umn.edu
Jenkins
M K
MK
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D001402:B-Lymphocytes / Q000276:immunology; D018106:CD28 Antigens; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D012486:Salmonella typhimurium / Q000276:immunology* / Q000472:pathogenicity*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014435:Typhoid Fever / Q000276:immunology* / Q000401:mortality; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology; D014774:Virulence
D000907:Antibodies, Bacterial; D018106:CD28 Antigens; D014436:Typhoid-Paratyphoid Vaccines