Lymphocyte signaling: Cbl sets the threshold for autoimmunity.
Cbl, a negative regulator of immune signaling, has recently been shown to act as a ubiquitin-protein ligase. Further, two new papers describing Cbl-b-deficient mice suggest that Cbl-b sets the threshold of signaling in T and B cells and prevents the development of autoimmunity.
Rudd
C E
CE
Division of Tumor Immunology, Department of Cancer Immunology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, USA. christopher_rudd@dfci.harvard.edu
Schneider
H
H
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D008025:Ligases / Q000276:immunology*; D051379:Mice; D010750:Phosphoproteins / Q000276:immunology*; D011518:Proto-Oncogene Proteins / Q000276:immunology*; D050721:Proto-Oncogene Proteins c-cbl; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases
D048868:Adaptor Proteins, Signal Transducing; D018106:CD28 Antigens; D002352:Carrier Proteins; C118387:Cblb protein, mouse; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; D008025:Ligases; C493849:Cbl protein, mouse