title: Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines.
abstract: Bisphosphonates (BPs) are commonly used in the treatment of myeloma-associated osteolytic lesions. Recent reports have suggested that BPs may also exert direct antitumor effects on myeloma cells. Here, we show that the treatment of myeloma cell lines with the combination of the potent BP zoledronate and dexamethasone inhibits cell growth and synergistically induces apoptotic cell death, providing a rationale for potential applications in vivo.
authors.affiliation: Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Catanzaro, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tassone
authors.forename: S
authors.initials: S
authors.lastname: Forciniti
authors.forename: E
authors.initials: E
authors.lastname: Galea
authors.forename: G
authors.initials: G
authors.lastname: Morrone
authors.forename: M C
authors.initials: MC
authors.lastname: Turco
authors.forename: V
authors.initials: V
authors.lastname: Martinelli
authors.forename: P
authors.initials: P
authors.lastname: Tagliaferri
authors.forename: S
authors.initials: S
authors.lastname: Venuta
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D003907:Dexamethasone / Q000633:toxicity*; D004164:Diphosphonates / Q000633:toxicity*; D004357:Drug Synergism; D005434:Flow Cytometry / Q000379:methods; D006801:Humans; D007093:Imidazoles / Q000633:toxicity*; D009101:Multiple Myeloma; D014407:Tumor Cells, Cultured; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D003907:Dexamethasone