title: Functionalized porous silica microspheres as scavengers in parallel synthesis.
abstract: The use of solid scavengers in parallel solution-phase organic synthesis is an effective method for work-up and purification. Functionalized macroreticular or gel-form polystyrene particles are generally used for scavenging applications, how ever these materials have some limitations. We have developed new scavenging reagents based on ultrapure silica microspheres displaying a variety of functional groups useful for sequestering impurities from reaction products. These materials are easy to handle, have excellent mass-transfer properties, and are efficient scavengers in both polar and nonpolar organic solvents. The properties of these materials were tailored specifically to fit the needs of a medicinal chemist employing parallel synthesis techniques in current commercial equipment. Results are presented from head-to-head comparisons with conventional scavengers in tests designed to demonstrate the versatility of these new materials.
authors.affiliation: DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA. drew.a.thompson@dupontpharma.com
authors.forename: L A
authors.initials: LA
authors.lastname: Thompsona
authors.forename: A P
authors.initials: AP
authors.lastname: Combsa
authors.forename: G L
authors.initials: GL
authors.lastname: Trainor
authors.forename: Q
authors.initials: Q
authors.lastname: Wangb
authors.forename: T J
authors.initials: TJ
authors.lastname: Langloisb
authors.forename: J J
authors.initials: JJ
authors.lastname: Kirkland
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008863:Microspheres; D015394:Molecular Structure; D012822:Silicon Dioxide / Q000737:chemistry*; D012997:Solvents
chemical_list: D000577:Amides; D012997:Solvents; D012822:Silicon Dioxide