Chromatography-free synthesis of 1,2,4-oxadiazoles using ROMPGEL-supported acylating reagents.
1,2,4-Oxadiazoles were synthesized in solution from aromatic amidoximes and acylating agents supported on a ring opening metathesis polymer (ROMPGEL) backbone. High yields and purities of the 1,2,4-oxadiazoles were obtained with minimal purification.
Barrett
A G
AG
Department of Chemistry, Imperial College of Science, Technology and Medicine, London, SW7 2AY, UK.
Roberts
R S
RS
Zécri
F J
FJ
Cramp
S M
SM
D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis*; D011108:Polymers; D012116:Resins, Plant
D010069:Oxadiazoles; D011108:Polymers; D012116:Resins, Plant