Cell replacement therapies for central nervous system disorders.
In animal models, immature neural precursors can replace lost neurons, restore function and promote brain self-repair. Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can be developed into effective clinical therapy?
Björklund
A
A
The authors are at the Wallenberg Neuroscience Center, Lund University, Sölvegatan 17, S-223 62 Lund, Sweden. anders.bjorklund@mphy.lu.se
Lindvall
O
O
D000818:Animals; D001921:Brain / Q000166:cytology* / Q000196:embryology; D017690:Cell Transplantation / Q000379:methods / Q000639:trends*; D002493:Central Nervous System Diseases / Q000628:therapy*; D002986:Clinical Trials as Topic; D004827:Epilepsy / Q000628:therapy; D006801:Humans; D006816:Huntington Disease / Q000628:therapy; D009474:Neurons / Q000637:transplantation*; D010300:Parkinson Disease / Q000628:therapy; D051381:Rats; D020127:Recovery of Function; D012640:Seizures / Q000517:prevention & control; D033581:Stem Cell Transplantation; D020521:Stroke / Q000628:therapy; D013552:Swine