[The interplay between embryo and endometrium is important for successful implantation. Increased knowledge can result in new contraceptive methods and better treatment of infertility].
It seems likely that local factors such as cytokines play an important role in synchronizing the development of the embryo and the gestational tract and in determining pregnancy outcome. Evaluation of the precise sequence of cytokines to which the embryo is exposed and responds during the critical periimplantation period may also make it possible to develop culture media which will improve embryo viability and hence increase implantation rates in IVF programs. In addition, an in vitro three-dimensional culture system is being developed which closely resembles endometrium in vivo. This system offers an opportunity to study the local molecular events involved in blastocyst adhesion and to elucidate the role played by local factors, such as cytokines, in producing a receptive luminal epithelium.
Danielsson
K G
KG
Kvinnokliniken, Karolinska sjukhuset, Stockholm. krgeda@obgyn.ks.se
D001755:Blastocyst / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D015815:Cell Adhesion Molecules / Q000502:physiology; D003271:Contraceptive Agents, Female / Q000600:supply & distribution; D016207:Cytokines / Q000502:physiology; D010064:Embryo Implantation / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D004717:Endometrium / Q000166:cytology / Q000276:immunology / Q000502:physiology* / Q000648:ultrastructure; D004847:Epithelial Cells / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism
D015815:Cell Adhesion Molecules; D003271:Contraceptive Agents, Female; D016207:Cytokines; D004967:Estrogens; D011374:Progesterone