title: [Time trends in cancer incidence in Navarra and Zaragoza, spain].
abstract: OBJECTIVE
  The knowledge of time-related changes occurring in cancer incidence and mortality is an essential element for cancer control. This paper aims to describe the time trends of the more important cancer sites in Navarra and Zaragoza.
  
  
  METHODS
  The influence of age, diagnosis period and birth cohort on the observed time trend cancer incidence in Navarre and Zaragoza was assessed using a log-linear model. Results are showed graphically, for the different tumour sites by sex and each registry.
  
  
  RESULTS
  Among males, a considerable rise in the incidence of lung cancer (5% per year), prostate cancer (> 2% per year) and non-Hodgkin's lymphomas was found. Among females, the highest increases corresponded to non-Hodgkin's lymphomas, with a yearly rise greater than 7%, and ovarian cancer (4% per year). Breast cancer in women increased in both registries (3.5% per year in Navarre and 0.9% per year in Zaragoza), part of the increment in Navarra being explained by a higher case detection rate. Finally, the incidence of colorectal, bladder and kidney cancer rose more than a 3% per year in both registries and sexes. For most types of tumours, cancer risk increased with subsequent generations.
  
  
  CONCLUSIONS
  The substantial cancer increment observed points out the inefficacy of primary prevention policies, the importance of studying cancer incidence for long time periods and the need to increase the population coverage of Spanish cancer registries.
authors.affiliation: Servicio de Epidemiología del Cáncer, Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, 28029, España. glabente@isciii.es
authors.forename: G
authors.initials: G
authors.lastname: López-Abente
authors.forename: M
authors.initials: M
authors.lastname: Pollán
authors.forename: A
authors.initials: A
authors.lastname: Vergara
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
authors.forename: P
authors.initials: P
authors.lastname: Moreo
authors.forename: C
authors.initials: C
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009369:Neoplasms / Q000453:epidemiology*; D016012:Poisson Distribution; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology