title: [Catastrophic pulmonary vasoconstriction associated with protamine reversal of heparin].
abstract: Administration of protamine intravenously to neutralize the anticoagulant effects of heparin may be associated with hypotension. These adverse cardiovascular responses to protamine fall into three distinct types: transient hypotension related to rapid drug administration; anaphylactic responses: and catastrophic pulmonary vasoconstriction. We recently observed three patients who had catastrophic pulmonary vasoconstriction, which were treated with the assist circulation and intraaortic balloon pumping. The two patients were survived except one who was dead due to the cerebral ischemic damage which was introduced by delayed establishment of circulatory assist device. We conclude that meticulous longstanding observation of the hemodynamic condition is important after administration of protamine under the unremoved cannulations.
authors.affiliation: Second Department of Surgery, Aichi Medical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Cao
authors.forename: K
authors.initials: K
authors.lastname: Shioi
authors.forename: C
authors.initials: C
authors.lastname: Narumiya
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.forename: T
authors.initials: T
authors.lastname: Mase
authors.forename: Y
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced / Q000628:therapy; D001243:Assisted Circulation; D006494:Heparin Antagonists / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007423:Intra-Aortic Balloon Pumping; D007431:Intraoperative Complications / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011479:Protamines / Q000008:administration & dosage / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D006494:Heparin Antagonists; D011479:Protamines