CD45 tyrosine phosphatase inhibitory components from Aspergillus niger.
Two inhibitors of CD45 tyrosine phosphatase, dihydrocarolic acid (1) and penitricin D (2), were isolated from a fermentation broth of the fungus Aspergillus niger and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by NMR. The inhibitory activities of both compounds were specific to tyrosine phosphatases.
Alvi
K A
KA
MDS Panlabs, Bothell, WA 98011-8805, USA.
Nair
B G
BG
Rabenstein
J
J
Davis
G
G
Baker
D D
DD
D001234:Aspergillus niger / Q000737:chemistry* / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D003521:Cyclopropanes / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005285:Fermentation; D005347:Fibroblasts / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D017493:Leukocyte Common Antigens / Q000187:drug effects / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors*
D003521:Cyclopropanes; D004791:Enzyme Inhibitors; D005663:Furans; C408298:dihydrocarolic acid; C408297:penitricin D; D004815:Epidermal Growth Factor; D017493:Leukocyte Common Antigens; D017027:Protein Tyrosine Phosphatases