title: Endoscopic ultrasound features of protein-losing gastropathy with hypertrophic gastric folds.
abstract: OBJECTIVE
  We aim to clarify the endoscopic ultrasound (EUS) features of protein-losing gastropathy with hypertrophic gastric folds (PLGH), including Ménétrier's disease.
  
  
  METHODS
  We analyzed the EUS and histologic findings in five patients who underwent both endoscopic ultrasonography and endoscopic resection.
  
  
  RESULTS
  Histologically, we diagnosed one patient as having acute gastritis, three patients as having Ménétrier's disease, and the remaining patient as having hypertrophic lymphocytic gastritis (HLG). Helicobacter pylori was recognized in all but one patient. At EUS every patient was found to have giant gastric folds (13 to 20 mm in diameter), resulting from echogenic thickening of the mucosal layer with or without cystic components. Two patients who underwent eradication therapy of H. pylori showed both clinical and morphologic resolution.
  
  
  CONCLUSIONS
  Echogenic thickening of the mucosal layer may be a characteristic EUS feature of protein-losing gastropathy with hypertrophic gastric folds, and H. pylori may be one of the causative agents.
authors.affiliation: Second Dept. of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hizawa
authors.forename: M
authors.initials: M
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Yao
authors.forename: K
authors.initials: K
authors.lastname: Aoyagi
authors.forename: H
authors.initials: H
authors.lastname: Suekane
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D019160:Endosonography; D005260:Female; D005758:Gastritis, Hypertrophic / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008875:Middle Aged; D011504:Protein-Losing Enteropathies / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies; D013270:Stomach / Q000000981:diagnostic imaging*