The synthesis of chiral cyanohydrins by oxynitrilases.
Enantiomerically pure cyanohydrins are important synthetic intermediates for pharmaceuticals and agrochemicals. They are produced by enzyme-catalysed synthesis using oxynitrilases. Sufficient quantities of enzyme are available via cheap natural sources and there have been recent advances in overexpression production of cyanohydrins on an industrial scale.
Griengl
H
H
Institute of Organic Chemistry, Technical University Graz, SFB Biocatalysis of the Austrian Science Fund, Stremayrgasse 16, A-8010 Graz, Austria. griengl@orgc.tu-graz.ac.at
Schwab
H
H
Fechter
M
M
D000446:Aldehyde-Lyases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D001671:Biochemistry / Q000379:methods*; D003001:Cloning, Molecular; D009570:Nitriles / Q000138:chemical synthesis* / Q000378:metabolism; D010944:Plants / Q000201:enzymology; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity
D009570:Nitriles; D011994:Recombinant Proteins; D000446:Aldehyde-Lyases; C021541:mandelonitrile lyase