Periodontal ligament formation around titanium implants using cultured periodontal ligament cells: a pilot study.
The aim of this study was to investigate whether a new periodontal ligament attachment will form on titanium implants when they are implanted with cultured periodontal ligament cells. Periodontal ligament cells obtained from the teeth of 3 dogs were cultured and attached to the surface of titanium implants. The implants with the cultured autologous periodontal ligament cells were placed in the mandibles of the dogs. After 3 months of healing, histologic examination revealed that, on some implant surfaces, a layer of cementum-like tissue with inserting collagen fibers had been achieved. These results demonstrated that cultured periodontal ligament cells can form tissue resembling a true periodontal ligament around implants.
Choi
B H
BH
Department of Oral and Maxillofacial Surgery, Yonsei University, Seoul, South Korea.
D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D017690:Cell Transplantation; D002478:Cells, Cultured; D003094:Collagen; D003238:Connective Tissue / Q000033:anatomy & histology; D003739:Dental Cementum / Q000033:anatomy & histology; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004285:Dogs; D008334:Mandible / Q000601:surgery; D010513:Periodontal Ligament / Q000166:cytology / Q000502:physiology*; D010865:Pilot Projects; D013499:Surface Properties; D014025:Titanium; D014182:Transplantation, Autologous; D014945:Wound Healing
D015921:Dental Implants; D003094:Collagen; D014025:Titanium