Matrix mini-tablets based on starch/microcrystalline wax mixtures.
Matrix mini-tablets based on a combination of microcrystalline waxes and starch derivatives were prepared using ibuprofen as a model drug. The production of mini-tablets was preferred over the production of pellets, as up-scaling of the pelletisation process seemed problematic. Prior to tabletting, melt granulation in a hot stage screw extruder and milling were required. The in vitro drug release was varied using microcrystalline waxes with a different melting range, the slowest drug release being obtained with a formulation containing a microcrystalline wax with a melting range between 68 and 72 degrees C. Generally speaking increasing the wax concentration resulted in a slower drug release. In vitro drug release profiles were also modified using different starches and mixtures of starches. Increasing the ibuprofen concentration to 70% resulted in a faster drug release rate.
De Brabander
C
C
Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Gent, Harelbekestraat 72, 9000, Gent, Belgium.
Vervaet
C
C
Fiermans
L
L
Remon
J P
JP
D002214:Capsules; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D007052:Ibuprofen / Q000008:administration & dosage; D008863:Microspheres; D013213:Starch; D014885:Waxes; D014961:X-Ray Diffraction
D002214:Capsules; D003692:Delayed-Action Preparations; D014885:Waxes; D013213:Starch; D007052:Ibuprofen