Factors influencing capping and cracking of mefenamic acid tablets.
The tendency of capping and longitudinal cracks of mefenamic acid tablets was evaluated in relation to the amount of the binder, the influence of the granulation technique, and the relative humidity of the granules. Tablets made from fluidized bed granules using methylcellulose in the granulating liquid showed significantly lower capping and longitudinal cracks than tablets from conventional granules prepared by wet granulation using methylcellulose as a dry binder.
Adam
A
A
Department of Pharmaceutical Technology, Eberhard-Karls-University Tübingen, Germany.
Schrimpl
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L
Schmidt
P C
PC
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D019245:Compressive Strength; D006813:Humidity; D008528:Mefenamic Acid / Q000008:administration & dosage / Q000737:chemistry*; D008747:Methylcellulose / Q000737:chemistry; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; D008528:Mefenamic Acid; D008747:Methylcellulose