title: Effects of exercise and alkalosis on serum insulin-like growth factor I and IGF-binding protein-3.
abstract: This investigation examines the effects of orally induced alkalosis on serum IGF-I and IGFBP3 concentrations in response to an acute 90-s bout of high intensity cycle exercise. Ten healthy, active men, ages 24.60 +/- 4.90 years, participated in a randomized, double-blind, counterbalanced trial order with a cross-over design. Subjects ingested an experimental bicarbonate solution or a placebo solution. Blood was sampled at baseline; pre-exercise; and 0, 5, 10, and 30 min postexercise. The pH between groups for pre-exercise and postexercise time points differed significantly (p < or = .05) in the experimental condition (from 7.42 +/- 0.01 to 7.35 +/- 0.02) versus the placebo condition (from 7.36 +/- 0.01 to 7.25 +/- 0.03). Increases in IGF-I over resting conditions occurred with placebo conditions at 5 and 10 min postexercise and in the experimental condition at 5 min postexercise. Concentrations of IGFBP3 were elevated above baseline at IP in both experimental and placebo conditions.
authors.affiliation: The Human Performance Laboratory, Ball State University, Muncie, IN 47306, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Kraemer
authors.forename: F S
authors.initials: FS
authors.lastname: Harman
authors.forename: N H
authors.initials: NH
authors.lastname: Vos
authors.forename: S E
authors.initials: SE
authors.lastname: Gordon
authors.forename: B C
authors.initials: BC
authors.lastname: Nindl
authors.forename: J O
authors.initials: JO
authors.lastname: Marx
authors.forename: A L
authors.initials: AL
authors.lastname: Gómez
authors.forename: J S
authors.initials: JS
authors.lastname: Volek
authors.forename: N A
authors.initials: NA
authors.lastname: Ratamess
authors.forename: S A
authors.initials: SA
authors.lastname: Mazzetti
authors.forename: J A
authors.initials: JA
authors.lastname: Bush
authors.forename: K
authors.initials: K
authors.lastname: Dohi
authors.forename: R U
authors.initials: RU
authors.lastname: Newton
authors.forename: K
authors.initials: K
authors.lastname: Häkkinen
mesh_terms: D000293:Adolescent; D000328:Adult; D000471:Alkalosis / Q000097:blood* / Q000503:physiopathology; D000704:Analysis of Variance; D001639:Bicarbonates / Q000008:administration & dosage; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005080:Exercise Test; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D010919:Placebos
chemical_list: D001639:Bicarbonates; D018972:Insulin-Like Growth Factor Binding Protein 3; D010919:Placebos; D007334:Insulin-Like Growth Factor I