title: Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke.
abstract: OBJECTIVE
  The heterogeneity of microvascular flows is known to be an important determinant of the efficacy of oxygen delivery to tissue. Studies in animals have demonstrated decreased flow heterogeneity (FH) in states of decreased perfusion pressure. The purpose of the present study was to assess microvascular FH changes in acute stroke with use of a novel perfusion-weighted MRI technique and to evaluate the ability of combined diffusion-weighted MRI and FH measurements to predict final infarct size.
  
  
  METHODS
  Cerebral blood flow, FH, and plasma mean transit time (MTT) were measured in 11 patients who presented with acute (<12 hours after symptom onset) stroke. Final infarct size was determined with follow-up MRI or CT scanning.
  
  
  RESULTS
  In normal brain tissue, the distribution of relative flows was markedly skewed toward high capillary flow velocities. Within regions of decreased cerebral blood flow, plasma MTT was prolonged. Furthermore, subregions were identified with significant loss of the high-flow component of the flow distribution, thereby causing increased homogeneity of flow velocities. In parametric maps that quantify the acute deviation of FH from that of normal tissue, areas of extreme homogenization of capillary flows predicted final infarct size on follow-up scans of 10 of 11 patients.
  
  
  CONCLUSIONS
  Flow heterogeneity and MTT can be rapidly assessed as part of a routine clinical MR examination and may provide a tool for planning of individual stroke treatment, as well as in targeting and evaluation of emerging therapeutic strategies.
authors.affiliation: Department of Radiology, MGH NMR Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA. leif@pet.auh.dk
authors.forename: L
authors.initials: L
authors.lastname: Ostergaard
authors.forename: A G
authors.initials: AG
authors.lastname: Sorensen
authors.forename: D A
authors.initials: DA
authors.lastname: Chesler
authors.forename: R M
authors.initials: RM
authors.lastname: Weisskoff
authors.forename: W J
authors.initials: WJ
authors.lastname: Koroshetz
authors.forename: O
authors.initials: O
authors.lastname: Wu
authors.forename: C
authors.initials: C
authors.lastname: Gyldensted
authors.forename: B R
authors.initials: BR
authors.lastname: Rosen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000175:diagnosis* / Q000503:physiopathology