The regulation of apoptosis in preantral ovarian follicles.
Less than 1% of ovarian follicles ever mature to ovulation. The remainder undergo atretic degeneration via apoptosis during development. Though the regulation of antral and preovulatory survival has been studied for many years, very little is known about the regulation of survival and development of preantral follicles. This review discusses recent findings regarding preantral follicle development with emphasis on the regulation of preantral follicle apoptosis.
McGee
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EA
Department of Obstetrics and Gynecology, University of Kentucky Chandler Medical Center, Lexington 40536-0084, USA. emcgee@pop.uky.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002470:Cell Survival / Q000187:drug effects; D006152:Cyclic GMP / Q000502:physiology; D005260:Female; D051526:Fibroblast Growth Factor 10; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D005640:Follicle Stimulating Hormone / Q000502:physiology; D006133:Growth Substances / Q000494:pharmacology; D006801:Humans; D006080:Ovarian Follicle / Q000502:physiology*
C496453:FGF7 protein, human; D051526:Fibroblast Growth Factor 10; D006133:Growth Substances; D051523:Fibroblast Growth Factor 7; D005346:Fibroblast Growth Factors; D005640:Follicle Stimulating Hormone; D006152:Cyclic GMP