title: Concentrative relationship between polymorphonuclear elastase and urinary trypsin inhibitor in amniotic fluid.
abstract: In the amniotic fluid, urinary trypsin inhibitor (UTI) seems to inhibit polymorphonuclear elastase (PMNE) activity. The PMNE and UTI concentrations in normal amniotic fluid at 16-20 and 38-40 gestational weeks were measured. The PMNE concentration increased significantly at 38-40 weeks, whereas UTI concentration decreased significantly. According to concentrative relationships between both substances, PMNE may be activated more at the full term pregnancy. Since PMNE-induced tissue injury potentially causes degradation of amniotic collagen, the present result suggests that the quotient of PMNE and UTI concentrations is a reliable index to estimate the occurrence of rupture of the membranes.
authors.affiliation: Department of Obstetrics & Gynecology, Central Aizu General Hospital, Aizuwakamatsu, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akutsu
authors.forename: H
authors.initials: H
authors.lastname: Iwama
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry*; D002585:Cesarean Section; D003404:Creatinine / Q000652:urine; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005865:Gestational Age; D006023:Glycoproteins / Q000032:analysis* / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D019272:Leukocyte Elastase / Q000032:analysis* / Q000097:blood; D011247:Pregnancy; D011863:Radioimmunoassay; D018709:Statistics, Nonparametric; D014361:Trypsin Inhibitors / Q000032:analysis* / Q000097:blood
chemical_list: D006023:Glycoproteins; D014361:Trypsin Inhibitors; D003404:Creatinine; D019272:Leukocyte Elastase; C028665:urinastatin