Pathology of a lepromatous eye.
Histopathological examination of an enucleated eye from a lepromatous leprosy patient showed the cornea, ciliary body, and part of the choroid to be infiltrated by macrophages filled with Mycobacterium leprae. The walls of blood vessels in the sclera, ciliary body and the anterior choroid demonstrated the presence of M. leprae, giving credence to the blood-borne entry of M. leprae into the eye. Unlike the eyes of experimental animals infected with M. leprae, histopathological study of this eye from a lepromatous leprosy patient demonstrated that M. leprae, although demonstrable in the anterior choroid, could not be found in the posterior parts of the eye, substantiating the claim that leprosy does not affect the posterior parts of the eye directly.
Ebenezer
G J
GJ
Department of Histopathology and Experimental Pathology, Schieffelin Leprosy Research and Training Center, Karigiri, Tamil Nadu, India.
Daniel
E
E
D000328:Adult; D005123:Eye / Q000382:microbiology / Q000473:pathology*; D015353:Eye Enucleation; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D007918:Leprosy / Q000382:microbiology / Q000473:pathology* / Q000601:surgery; D008264:Macrophages / Q000382:microbiology; D009166:Mycobacterium leprae / Q000472:pathogenicity*