Vaccination against Taenia solium cysticercosis in underfed rustic pigs of México: roles of age, genetic background and antibody response.
Vaccination of pigs of mixed genetic make-up, raised as rustically as done in rural Mexico, resulted in effective protection to experimental challenge against Taenia solium cysticercosis. Maximum protection was achieved if pigs were immunized at 70 days of age. There was large variation of viable parasite load within vaccinated pigs and controls, which is suggestive of significant genetic factors influencing susceptibility, besides immunization. Our results strengthen the advisability of pig vaccination for control of T. solium cysticercosis, since it lowers the number of viable cysticerci capable of transforming into tapeworms.
Huerta
M
M
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Sciutto
E
E
García
G
G
Villalobos
N
N
Hernández
M
M
Fragoso
G
G
Díaz
J
J
Díaz
A
A
Ramírez
R
R
Luna
S
S
García
J
J
Aguilar
E
E
Espinoza
S
S
Castilla
G
G
Bobadilla
J R
JR
Avila
R
R
José
M V
MV
Larralde
C
C
de Aluja
A S
AS
D000367:Age Factors; D000818:Animals; D000909:Antibodies, Helminth / Q000096:biosynthesis*; D003551:Cysticercosis / Q000517:prevention & control / Q000662:veterinary*; D020022:Genetic Predisposition to Disease; D008800:Mexico; D013552:Swine; D013553:Swine Diseases / Q000235:genetics / Q000276:immunology / Q000517:prevention & control*; D013621:Taenia / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*
D000909:Antibodies, Helminth