title: Induced hypothermia in experimental pneumococcal meningitis.
abstract: Pneumococcal meningitis resulting from Streptococcus pneumoniae has a death rate of 28% in adults. In severe head injury and stroke, inflammatory changes and intracranial hypertension are improved by induced hypothermia, which also is neuroprotective. We hypothesized that moderate hypothermia ameliorates inflammatory changes in experimental pneumococcal meningitis. Wistar rats were cooled systemically, and meningitis was induced by pneumococcal cell wall components. The increase of regional cerebral blood flow in the meningitis animals was blocked by hypothermia at 6 hours. The reduction of intracranial pressure correlated with temperature. The influx of leukocytes into the cerebrospinal fluid and levels of tumor necrosis factor alpha in the cerebrospinal fluid were decreased. Cooling the animals 2 hours after meningitis induction to 30.5 degrees C was also protective. We conclude that hypothermia is a new adjuvant approach to reduce meningitis-induced changes, in particular intracranial pressure, in the early phase of the disease.
authors.affiliation: Department of Neurology, Universitaetsklinikum Charité, Humboldt University, Berlin, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Angstwurm
authors.forename: S
authors.initials: S
authors.lastname: Reuss
authors.forename: D
authors.initials: D
authors.lastname: Freyer
authors.forename: G
authors.initials: G
authors.lastname: Arnold
authors.forename: U
authors.initials: U
authors.lastname: Dirnagl
authors.forename: R R
authors.initials: RR
authors.lastname: Schumann
authors.forename: J R
authors.initials: JR
authors.lastname: Weber
mesh_terms: D000818:Animals; D002555:Cerebrospinal Fluid / Q000166:cytology; D002560:Cerebrovascular Circulation; D007036:Hypothermia, Induced; D007427:Intracranial Pressure; D008297:Male; D008586:Meningitis, Pneumococcal / Q000134:cerebrospinal fluid / Q000503:physiopathology / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
chemical_list: D014409:Tumor Necrosis Factor-alpha