Inhibition of tumor growth by interleukin 10 gene transfer in B16(F10) melanoma cells.
Interleukin 10 (IL-10) is a potent immunosuppressive cytokine with an antitumor activity. The effect of IL-10 on tumor growth was tested in murine melanoma cells manipulated by gene transfer to secrete IL-10. In mice bearing B16(F10) tumors expressing IL-10 tumor growth was decreased depending on the amount of secreted IL-10.
Walos
S
S
Department of Molecular Biology, Center of Oncology-Maria Skłodowska-Curie Memorial Institute, Gliwice, Poland.
Szary
J
J
Szala
S
S
D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D016753:Interleukin-10 / Q000096:biosynthesis* / Q000235:genetics* / Q000627:therapeutic use; D008546:Melanoma, Experimental / Q000235:genetics* / Q000276:immunology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D014407:Tumor Cells, Cultured
D016753:Interleukin-10