title: Effect of glycemic control and vitamin E supplementation on total glutathione content in non-insulin-dependent diabetes mellitus.
abstract: Thirty patients with non-insulin-dependent diabetes mellitus were selected for the study. 15 age-matched healthy volunteers served as controls. Serum malonaldehyde, total glutathione, and vitamin E levels were estimated before and after glycemic control and after 4 weeks of vitamin E supplementation. Both total glutathione and vitamin E levels increased after glycemic control and showed an increase after vitamin E supplementation. Malonaldehyde levels lowered after glycemic control, but remained higher than controls. Since vitamin E supplementation significantly decreased oxidative stress in the present study, it may play a role in reducing free-radical-induced oxidant injury in diabetes mellitus.
authors.affiliation: Department of Biochemistry, Postgraduate Institute of Medical Sciences, Rohtak, India.
authors.forename: A
authors.initials: A
authors.lastname: Sharma
authors.forename: S
authors.initials: S
authors.lastname: Kharb
authors.forename: S N
authors.initials: SN
authors.lastname: Chugh
authors.forename: R
authors.initials: R
authors.lastname: Kakkar
authors.forename: G P
authors.initials: GP
authors.lastname: Singh
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D019587:Dietary Supplements; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood
chemical_list: D001786:Blood Glucose; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione