title: Coumarins and carbazoles with antiplasmodial activity from Clausena harmandiana.
abstract: Activity guided fractionation of extracts from Clausena harmandiana have led to the identification of four known compounds, heptaphylline (1), clausine K (2), dentatin (5), and clausarin (6). All these compounds, except clausine K (2), exhibited antiplasmodial activity against Plasmodium falciparum. While the new dimethylated derivative 4, derived from 2, showed no antiplasmodial activity, the monomethylated product 3 (clausine H) exhibited activity comparable to that observed for compounds 1 and 5.
authors.forename: C
authors.initials: C
authors.lastname: Yenjai
authors.forename: S
authors.initials: S
authors.lastname: Sripontan
authors.forename: P
authors.initials: P
authors.lastname: Sriprajun
authors.forename: P
authors.initials: P
authors.lastname: Kittakoop
authors.forename: A
authors.initials: A
authors.lastname: Jintasirikul
authors.forename: M
authors.initials: M
authors.lastname: Tanticharoen
authors.forename: Y
authors.initials: Y
authors.lastname: Thebtaranonth
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010944:Plants / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D002227:Carbazoles; D003374:Coumarins