Current understanding of androgenetic alopecia. Part I: etiopathogenesis.
Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. This continuous process results in a type of alopecia that follows a definite pattern in those individuals who are genetically predisposed. At present the predisposing genes are unknown but the relatively strong concordance of the degree of baldness in fathers and sons is not consistent with a simple Mendelian trait and a polygenic basis is therefore most likely. AGA can be defined as a DHT-dependent process with continuous miniaturization of sensitive HF. Today we do not understand the molecular steps involved in androgen-dependent beard growth versus androgen-dependent hair loss in AGA. However, recent experimental and clinical advances enable us to explain some pathogenetic steps leading to androgenetic hair loss. Among other steroidogenic isoenzymes such as 17b- and 3b- hydroxysteroid dehydrogenases, the type 2 5a-reductase within the dermal papilla plays a central role by the intrafollicular conversion of T to DHT.
Hoffmann
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Department of Dermatology, Philipp University, Deutschhausstr. 9, D-35033 Marburg, Germany.
Happle
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D015067:17-Hydroxysteroid Dehydrogenases / Q000235:genetics / Q000378:metabolism; D000505:Alopecia / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D000728:Androgens / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001141:Aromatase / Q000235:genetics / Q000378:metabolism; D001192:Arylsulfatases / Q000235:genetics / Q000378:metabolism; D042944:Cholestenone 5 alpha-Reductase; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D018859:Hair Follicle / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010088:Oxidoreductases / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D011375:Progesterone Reductase / Q000235:genetics / Q000378:metabolism; D011944:Receptors, Androgen / Q000235:genetics* / Q000378:metabolism; D012729:Sex Chromosome Aberrations / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D013251:Steroid Isomerases / Q000235:genetics / Q000378:metabolism; D043266:Steryl-Sulfatase; D014960:X Chromosome
C021425:3 beta-hydroxysteroid oxidoreductase-delta(5) 3-ketosteroid isomerase; D000728:Androgens; D005819:Genetic Markers; D009097:Multienzyme Complexes; D011944:Receptors, Androgen; D010088:Oxidoreductases; D015067:17-Hydroxysteroid Dehydrogenases; D011375:Progesterone Reductase; D001141:Aromatase; D042944:Cholestenone 5 alpha-Reductase; D001192:Arylsulfatases; D043266:Steryl-Sulfatase; D013251:Steroid Isomerases