Paradoxical response to antitubercular drugs.
Seven patients with paradoxical response to antitubercular drugs are reported. In three cases of intracranial tuberculomas, newer lesions appeared and in two cases preexisting tuberculomas enlarged. In two cases of tubercular meningitis, multiple tuberculomas appeared. All these cases exhibited newer symptoms and CT/MBI revealed the paradoxical response to antitubercular drugs. All responded to continued conservative therapy, with addition of pyrazinamide.
Kumar
S
S
Department of Neurosurgery, Neurology and Radiology, G.B. Pant Hospital, New Delhi.
Puri
V
V
Mehndiratta
M M
MM
Gupta
S
S
Bhutani
A
A
Sharma
C
C
D000293:Adolescent; D000995:Antitubercular Agents / Q000009:adverse effects*; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D014057:Tomography, X-Ray Computed; D014375:Tuberculoma / Q000209:etiology / Q000473:pathology*; D014390:Tuberculosis, Meningeal / Q000188:drug therapy / Q000473:pathology
D000995:Antitubercular Agents