Soluble-polymer supported synthesis of a prostanoid library: identification of antiviral activity.
[formula: see text] The prostaglandins are potent natural products taking part in many biological processes. The "convergent generation of diversity" from a "toolbox" of prostanoid components, augmented with additional polymer-supported transformations, can enable construction of valuable libraries. A parallel-pool strategy was used to assemble a small library of prostanoids. The inhibition of a herpes-family virus demonstrated the potential for new drug discovery.
Lee
K J
KJ
Department of Chemistry, Scripps Research Institute, La Jolla, California 92037, USA.
Angulo
A
A
Ghazal
P
P
Janda
K D
KD
D016475:3T3 Cells; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003587:Cytomegalovirus / Q000187:drug effects; D015774:Ganciclovir / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D019151:Peptide Library; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D019151:Peptide Library; D011453:Prostaglandins; D015774:Ganciclovir