title: Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood.
abstract: OBJECTIVE
  To determine the clinical, physical, sperm and hormonal status during adulthood in cryptorchid patients operated on during childhood, and to assess these variables according to the age at surgery and preoperative testicular position.
  
  
  METHODS
  A letter was sent to all 890 patients > 18 years old who underwent surgery for cryptorchidism during childhood; 274 responded and were assessed using a sexual history, physical examination, pituitary axis study and sperm analysis. Data were complete for 251 patients (mean age 21 years, range 18-30); 196 had unilateral (25 anorchic) and 55 had bilateral cryptorchidism. Clinical, surgical and anatomopathological records at surgery during childhood were also reviewed.
  
  
  RESULTS
  The mean (SD) age at orchidopexy was 6.4 (3.3) years and the mean age at assessment 21.1 (2.7) years. Semen samples generally showed abnormalities; 10 patients (4%) with bilateral and 57 (23%) with unilateral cryptorchidism had semen values within the normal range. There was no correlation between the sperm count and age at surgery for unilateral or bilateral cases (Spearman test). There was a significant correlation (r = - 0.41) between the sperm count and level of follicle-stimulating hormone (FSH). There were no significant differences in the sperm count for patients with different testicular locations (ANOVA) or in those treated or untreated with human chorionic gonadotrophin (Student's t-test). The only significant relationship (P < 0.001) was between the sperm count and unilateral or bilateral cryptorchidism.
  
  
  CONCLUSIONS
  The sperm quality of adults operated on for cryptorchidism during childhood is independent of the age at surgery or testicular location, but is influenced by whether the cryptorchidism was unilateral or bilateral. FSH levels were negatively correlated with sperm density.
authors.affiliation: Departments of Paediatric Surgery, Urology, Hormonal Laboratory and Paediatrics, 'Miguel Servet' Children's Hospital and Department of Urology, 'Lozano Blesa' Hospital, Zaragoza, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Gracia
authors.forename: J
authors.initials: J
authors.lastname: Sánchez Zalabardo
authors.forename: J
authors.initials: J
authors.lastname: Sánchez García
authors.forename: C
authors.initials: C
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Ferrández
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003456:Cryptorchidism / Q000097:blood / Q000150:complications* / Q000601:surgery; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000097:blood / Q000209:etiology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009919:Orchiectomy / Q000009:adverse effects*; D013076:Sperm Count; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone