Liposome-delivered angiostatin strongly inhibits tumor growth and metastatization in a transgenic model of spontaneous breast cancer.
The possibility to inhibit tumor growth by interfering with the formation of new vessels, which most neoplasias depend on, has recently raised considerable interest. An angiogenic switch, in which proliferating cells acquire the ability to direct new vessel formation, is thought to be an early step in the natural history of solid tumors. Using a transgenic model of breast cancer, which shows many similarities to its human counterpart, including ability to metastasize, we targeted angiostatin production to an early stage of tumor formation. Liposome-delivered angiostatin considerably delayed primary tumor growth and, more importantly, inhibited the appearance of lung metastases. These findings can be relevant to the design of therapeutic intervention in humans.
Sacco
M G
MG
Department of Human Genome and Multifactorial Diseases, Istituto di Tecnologie Biomediche Avanzate, Consiglio Nazionale delle Ricerche, Milan, Italy.
Caniatti
M
M
Catò
E M
EM
Frattini
A
A
Chiesa
G
G
Ceruti
R
R
Adorni
F
F
Zecca
L
L
Scanziani
E
E
Vezzoni
P
P
D043168:Angiostatins; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D015316:Genetic Therapy; D006801:Humans; D008081:Liposomes; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D010446:Peptide Fragments / Q000008:administration & dosage* / Q000627:therapeutic use*; D010958:Plasminogen / Q000008:administration & dosage* / Q000627:therapeutic use*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics; D011991:Receptors, Virus / Q000235:genetics
D043168:Angiostatins; D000970:Antineoplastic Agents; D008081:Liposomes; D008565:Membrane Proteins; D010446:Peptide Fragments; D010958:Plasminogen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011991:Receptors, Virus; C111417:Fam89b protein, mouse