Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouse.
Chemokine mRNA expression by pulmonary leukocytes following infection of BALB/c mice with two strains of respiratory syncytial virus (RSV) and one strain of parainfluenza virus type 3 (PIV-3) was determined. The results suggest that RSV G and/or SH proteins inhibit early MIP-1alpha, MIP-1beta, MIP-2, MCP-1, and IP-10 mRNA expression. TCA-3 mRNA expression was found to be increased during PIV-3 infection.
Tripp
R A
RA
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. rgt3@cdc.gov
Jones
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L
Anderson
L J
LJ
D000818:Animals; D054402:Chemokine CCL1; D018932:Chemokine CCL2 / Q000235:genetics; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000235:genetics; D054357:Chemokine CXCL10; D054426:Chemokine CXCL2; D019742:Chemokines, CC / Q000235:genetics*; D019743:Chemokines, CXC / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D015707:HN Protein; D019402:Macrophage Inflammatory Proteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D015846:Monokines / Q000235:genetics; D010224:Parainfluenza Virus 3, Human / Q000378:metabolism / Q000502:physiology; D012333:RNA, Messenger; D054401:Receptors, CCR8; D018113:Respiratory Syncytial Virus, Human / Q000235:genetics / Q000378:metabolism*; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
C065971:CCL1 protein, human; C489319:Ccr8 protein, mouse; D054402:Chemokine CCL1; D018932:Chemokine CCL2; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054426:Chemokine CXCL2; D019742:Chemokines, CC; D019743:Chemokines, CXC; D016207:Cytokines; D006023:Glycoproteins; D015707:HN Protein; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D012333:RNA, Messenger; D054401:Receptors, CCR8; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C116204:attachment protein G