title: Impact of Helicobacter pylori eradication on the development of MALT, gland atrophy and intestinal metaplasia of the antrum.
abstract: BACKGROUND
  Chronic Helicobacter pylori infection leads to the development of mucosa-associated lymphoid tissue (MALT), gland atrophy, intestinal metaplasia, and in certain individuals, gastric lymphoma and adenocarcinoma. We conducted a prospective study to determine the effect of H pylori eradication on the development of MALT, gland atrophy and intestinal metaplasia.
  
  
  METHODS
  From July 1995 to October 1996, 63 consecutive patients with H pylori-associated peptic ulcer disease were enrolled in a bacterial eradication trial. The grade of MALT and the degree of gastritis of the antrum were assessed using Wotherspoon's scale and the Sydney system before treatment, and at eight weeks and one year after H pylori eradication therapy.
  
  
  RESULTS
  During the study period, 43 patients received complete follow-up. In the patient group with eradication failure (n = 22), MALT score was significantly decreased at the end of the eighth week (p < 0.05) but returned to the initial level by one year of follow-up. There were no changes in the scores for inflammation, neutrophil activity, gland atrophy or intestinal metaplasia at the end of the eighth week and at one year following H pylori eradication therapy. In contrast, there was a marked reduction in the MALT, inflammation, and activity scores at eight weeks (p < 0.01, < 0.05 and < 0.05, respectively) and one year after treatment (p < 0.05, < 0.001 and < 0.001, respectively) in the patient group with successful eradication (n = 21). However, no significant changes in gland atrophy and intestinal metaplasia were observed during the follow-up period.
  
  
  CONCLUSIONS
  Eradication of H pylori leads to regression of MALT in the stomach, but the degrees of gland atrophy and intestinal metaplasia remain unchanged, even after one-year of follow-up.
authors.affiliation: Department of Internal Medicine, Veterans General Hospital-Kaohsiung, National Yang-Ming University, Taiwan, ROC.
authors.forename: P I
authors.initials: PI
authors.lastname: Hsu
authors.forename: K H
authors.initials: KH
authors.lastname: Lai
authors.forename: H H
authors.initials: HH
authors.lastname: Tseng
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: G H
authors.initials: GH
authors.lastname: Lo
authors.forename: J S
authors.initials: JS
authors.lastname: Cheng
authors.forename: H H
authors.initials: HH
authors.lastname: Chan
authors.forename: J H
authors.initials: JH
authors.lastname: Hsu
authors.forename: H S
authors.initials: HS
authors.lastname: Jou
authors.forename: L P
authors.initials: LP
authors.lastname: Ger
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: P N
authors.initials: PN
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D001284:Atrophy; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000209:etiology; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011706:Pyloric Antrum