Fat distribution and HIV protease inhibitors.
(1) Disturbing changes in body fat distribution started to be described in 1997 in HIV-infected patients treated with antiretroviral drugs, with fat accumulation at various levels of the trunk, and thinning of the limbs, buttocks and face. (2) The vast majority of cases occurred in patients on HIV protease inhibitors. (3) The long-term clinical consequences are unknown.
D000273:Adipose Tissue / Q000187:drug effects*; D019380:Anti-HIV Agents / Q000493:pharmacokinetics; D001835:Body Weight / Q000187:drug effects*; D006801:Humans; D011480:Protease Inhibitors / Q000493:pharmacokinetics*
D019380:Anti-HIV Agents; D011480:Protease Inhibitors