title: [Molecular pathogenesis of lung cancer].
abstract: Lung cancer is the largest cancer killer of men and women in the world. In addition to the progress made from antismoking primary prevention measures, new tools to help treat patients with lung cancer are emerging from the rapid advances in knowledge of the molecular pathogenesis of lung cancer. These tools include molecular and cellular biology and are starting to provide an insight into how the tumor cells, by altering oncogenes and tumor suppressor genes, achieves growth advantage, uncontrolled proliferation and metastatic behavior via disruption of key cell-cycle regulators and signal transduction cascades. These tools are being translated into clinical strategies to complement surgery, radiotherapy, and chemotherapy and also to assist in primary and secondary prevention efforts. From the current knowledge of the molecular pathogenesis of lung cancer we know that respiratory epithelial cells require many genetic alterations to become invasive and metastatic cancer.
authors.affiliation: Aichi Cancer Center Research Institute, Laboratory of Ultrastructure Research.
authors.forename: H
authors.initials: H
authors.lastname: Osada
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D002453:Cell Cycle / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D016161:Genes, Retinoblastoma / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000235:genetics; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D009154:Mutation
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16