title: Enzymatic selective dehydration and skeleton rearrangement of paclitaxel precursors.
abstract: [formula: see text] Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives 2a-c are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids in good yields.
authors.affiliation: Department of Chemistry, Pohang University of Science and Technology, Korea.
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: M J
authors.initials: MJ
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014867:Water; D017239:Paclitaxel