Comparative analysis of proinflammatory cytokines in plasma of mice exposed to radiation or in combined radiation injury.
Male mice (CBA x C57BL/6)F1 were used for the experiments throughout this study. Blood serum levels of IL-1 beta, IL-6, TNF-alpha, IL-3, and GM-CSF were evaluated by means of enzyme-linked immunosorbent assay at 3, 6, 24, 48 and 72 hours after 7 Gy gamma-irradiation alone or combined injury (irradiation + thermal burn). Radiation as well as combined injury did not cause any important alterations of IL-1 beta, TNF-alpha, IL-3, and GM-CSF concentrations in the system circulation. Combined injury revealed more enhanced serum levels of IL-6 versus only irradiated mice. A possible significance of this phenomenon at the combined radiation and thermal burns' pathogenesis is discussed.
Budagov
R S
RS
Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk. budagov@obninsk.com
Ul'ianova
L P
LP
D000818:Animals; D016207:Cytokines / Q000097:blood* / Q000276:immunology / Q000528:radiation effects; D007249:Inflammation / Q000097:blood / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000276:immunology
D016207:Cytokines