Mutagenic evaluation of deltamethrin using rodent dominant lethal assay.
The dominant lethal test was used to analyse the mutagenic potential of deltamethrin, a synthetic pyrethroid insecticide, in Swiss albino mice. In the treated series, the animals were exposed orally to three different doses (0.36, 0.72 and 1.08 mg/kg body weight) of deltamethrin dissolved in corn oil. Following the treatment, each male of control, as well as of the treated series, was mated with untreated females, every week for a period of 6 weeks. All mated females were sacrificed on the 13th day of separation and their ovaries and uterus were examined. The results revealed that deltamethrin treatment did not impair the mating capacity and fertility of Swiss albino mice. Mutagenic index, pre- and post-implantation losses were assessed. No significant pre-implantation losses were observed either weekly or averagely. Post-implantation losses were observed at medium and high doses of deltamethrin. A slight increase in dominant lethal mutation rate was observed by increasing doses of deltamethrin in early weeks but decreased in later weeks, so an apparent dose response was not observed.
Shukla
Y
Y
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P.O. Box 80, M.G. Marg, 226 001, Lucknow, India. yshukla@itrc.sirnetd.ernet.in
Taneja
P
P
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005804:Genes, Lethal / Q000187:drug effects* / Q000235:genetics; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009570:Nitriles; D011247:Pregnancy; D011722:Pyrethrins / Q000633:toxicity*; D012726:Sexual Behavior, Animal / Q000187:drug effects
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin