The Lynch Syndrome: Melding Natural History and Molecular Genetics to Genetic Counseling and Cancer Control.
Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.
Lynch
HT
Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
Lynch
JF