Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.
The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide significantly protected clonic seizures induced by PTZ in a dose-dependent manner. The effect of thioperamide was completely countered by pretreatment with R (alpha)-methylhistamine (RAMH), a selective H3-receptor agonist suggesting that the observed effect of thioperamide was elicited by histamine H3-receptors. RAMH alone did not significantly modify PTZ seizures. The findings are consistent with a role for the histaminergic neuronal system in seizures and suggest that H3-receptors may play an important role in modulating clonic seizures induced by PTZ in mice.
Vohora
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Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Pal
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Pillai
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D000818:Animals; D004305:Dose-Response Relationship, Drug; D006633:Histamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008761:Methylhistamines / Q000494:pharmacology; D051379:Mice; D010433:Pentylenetetrazole; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D018100:Receptors, Histamine H3 / Q000187:drug effects / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D006633:Histamine Antagonists; D008761:Methylhistamines; D010880:Piperidines; D020011:Protective Agents; D018100:Receptors, Histamine H3; C069357:alpha-methylhistamine; C052075:thioperamide; D010433:Pentylenetetrazole