Polyphosphorylation and non-enzymatic template-directed ligation of oligonucleotides.
Oligonucleotide 5'-polyphosphates are formed under potentially prebiotic conditions from oligonucleotide 5'-phosphates and sodium trimetaphosphate. Oligonucleotides activated as polyphosphates undergo template-directed ligation. We believe that these reactions could have produced longer oligonucleotide products from shorter substrates under prebiotic conditions.
Gao
K
K
The Salk Institute for Biological Studies, San Diego, CA 92186-5800, USA.
Orgel
L E
LE
D004591:Electrophoresis, Polyacrylamide Gel; D009841:Oligonucleotides / Q000378:metabolism*; D010766:Phosphorylation; D011122:Polyphosphates / Q000378:metabolism*; D013698:Templates, Genetic
D009841:Oligonucleotides; D011122:Polyphosphates