title: Effect of anaesthesia on the cardiac response to intravenous adenosine.
abstract: The cardiac response to intravenous adenosine 112 micrograms kg-1 was studied in 16 patients scheduled for coronary artery bypass surgery before and during anaesthesia with 1% end-tidal isoflurane and fentanyl 10 micrograms kg-1. Mean time from injection to onset of adenosine-induced PR prolongation was significantly greater during anaesthesia (12.8 (SD 5) vs 9.9 (3) s, P = 0.032). Atrioventricular block (assessed by the total number of non-conducted P waves) was significantly less during anaesthesia (12 vs 27, P = 0.016). We conclude that anaesthesia including 1% isoflurane and fentanyl 10 micrograms kg-1 delays the onset and reduces the magnitude of adenosine-induced atrioventricular block.
authors.affiliation: Department of Anaesthesia, Northern General Hospital, Sheffield, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Morgan-Hughes
authors.forename: K M
authors.initials: KM
authors.lastname: Sherry
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001026:Coronary Artery Bypass; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007530:Isoflurane / Q000008:administration & dosage; D008297:Male; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D000889:Anti-Arrhythmia Agents; D007530:Isoflurane; D000241:Adenosine; D005283:Fentanyl