title: [Orodental management in patients with malignant hematologic diseases who are waiting for bone marrow transplantation].
abstract: BACKGROUND
  This study aims to identify the main oral lesions caused by the use of chemotherapeutic agents pre- and post-transplant in malignant hemopathologies and to highlight the importance of dental prevention during this treatment in order to reduce and, if possible, avoid the resulting local and systemic complications.
  
  
  METHODS
  Twenty-five patients were controlled, monitored and prepared to undergo the necessary chemo- and radiotherapy, as well as bone marrow transplantation in the majority of cases under the best possible oral conditions.
  
  
  RESULTS
  The most commonly detected secondary lesions were reactions to cyclophosphamide and/or methotrexate. In general, this mucositis appeared 5-7 days after treatment and continued for 1-2 weeks before regressing without residue. Another post-radiotherapeutic complication observed was xerostomy.
  
  
  CONCLUSIONS
  Lastly, it is important to underline that patients receiving correct dental infection preventive treatment showed fewer tertiary lesions than those who did not undergo the same procedure.
authors.forename: M
authors.initials: M
authors.lastname: Bocca
authors.forename: D
authors.initials: D
authors.lastname: Coscia
authors.forename: L
authors.initials: L
authors.lastname: Bottalico
authors.forename: R
authors.initials: R
authors.lastname: De Stefano
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology* / Q000628:therapy*; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents