[Lithium oxybutyrate and the rhythmic structure of the actively exploratory behavior and body temperature in rats under constant illumination conditions].
Under constant illumination (LL 24) conditions, lithium hydroxybutyrate (LHB, daily dose 10 mg/kg, 10 days) facilitated the formation of synchronized 24-h rhythms in the active-search (open-field) behavior and body temperature variation in rats, independently of the objective drug administration time. In the dark (DD 24), LHB increased the free-running rhythms and facilitated synchronization of the internal harmonics, especially upon the drug administration in the objective p.m. phase.
Zamoshchina
T A
TA
Pharmacology Department, Siberian Medical University, Tomsk, Russia.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology*; D010507:Periodicity; D017440:Photoperiod; D051381:Rats; D017208:Rats, Wistar; D012621:Seasons; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium