title: In search of gamma-secretase: presenilin at the cutting edge.
authors.affiliation: Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, HIM 730, Boston, MA 02115, USA. selkoe@cnd.bwh.harvard.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Selkoe
authors.forename: M S
authors.initials: MS
authors.lastname: Wolfe
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology*; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D016282:Aspartic Acid Endopeptidases; D001665:Binding Sites; D002793:Cholic Acids / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology; D019281:Dimerization; D010450:Endopeptidases / Q000302:isolation & purification / Q000502:physiology*; D004722:Endoribonucleases; D006367:HeLa Cells / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000302:isolation & purification / Q000502:physiology*; D053764:Presenilin-1; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017434:Protein Structure, Tertiary; D051880:Receptors, Notch; D013379:Substrate Specificity
chemical_list: D016564:Amyloid beta-Protein Precursor; D002793:Cholic Acids; D003902:Detergents; D046911:Macromolecular Substances; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D051880:Receptors, Notch; C048531:chapso; C403982:ERN2 protein, human; D017346:Protein Serine-Threonine Kinases; D004722:Endoribonucleases; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human; C028213:3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate