title: Hypersensitivity syndrome caused by amitriptyline administration.
abstract: Adverse cutaneous manifestations are among the most common side effects associated with psychotropic drugs. Skin reactions due to amitriptyline (a tricyclic antidepressant agent) include rashes and hypersensitivity reactions (for example, urticaria and photosensitivity) as well as hyperpigmentation. Hypersensitivity syndrome is a specific severe idiosyncratic reaction causing skin, liver, joint, and haematological abnormalities, which usually resolve after the discontinuation of the implicated drug. A case of a 24 year old woman who experienced hypersensitivity syndrome three weeks after the initiation of amitriptyline is reported.
authors.affiliation: Department of Internal Medicine, Medical School, University of Ioannina, GR 451 10 Ioannina, Greece.
authors.forename: H J
authors.initials: HJ
authors.lastname: Milionis
authors.forename: A
authors.initials: A
authors.lastname: Skopelitou
authors.forename: M S
authors.initials: MS
authors.lastname: Elisaf
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D005938:Glucocorticoids; D000639:Amitriptyline; D011239:Prednisolone