Spatial learning affects immature granule cell survival in adult rat dentate gyrus.
Neurogenesis occurs throughout life in mammalian dentate gyrus. The effect of learning on newborn cell survival was studied in rat. Rats were trained on a hippocampus-dependent spatial learning task by using Morris water maze. Neurogenesis was evaluated by 5-bromo-2'deoxyuridine administered before learning. Several newborn cells expressed the immature neuron marker TOAD-64. The main findings were as follows: (1) the survival of newborn cells was enhanced by learning at early stage of differentiation; (2) the newborn cells saved by learning were mainly located in the rostral part of external blade of granule cell layer and (3) there was a correlation between the actual individual learning and newborn cell survival.
Ambrogini
P
P
Institute of Physiological Sciences, University of Urbino, I-61029, Urbino, Italy. p.ambrogini@uniurb.it
Cuppini
R
R
Cuppini
C
C
Ciaroni
S
S
Cecchini
T
T
Ferri
P
P
Sartini
S
S
Del Grande
P
P
D000367:Age Factors; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D015415:Biomarkers; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002452:Cell Count; D002455:Cell Division / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D018891:Dentate Gyrus / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology*
D000963:Antimetabolites; D015415:Biomarkers; D001973:Bromodeoxyuridine