Gram-scale synthesis of (+)-discodermolide.
[formula: see text] A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.
Smith
A B
AB
Department of Chemistry, Monell Chemical Senses Center, University of Pennsylvania 19104, USA. smithab@sas.upenn.edu
Kaufman
M D
MD
Beauchamp
T J
TJ
LaMarche
M J
MJ
Arimoto
H
H
D000473:Alkanes; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002219:Carbamates; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D011753:Pyrones; D013237:Stereoisomerism
D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007202:Indicators and Reagents; D007783:Lactones; D011753:Pyrones; C071229:discodermolide