title: In vitro study of antibacterial and antiadhesive activities of fluoride-containing light-cured fissure sealants and a glass ionomer liner/base against oral bacteria.
abstract: The aim of this study was to estimate the antibacterial and anti-adhesive properties of light-cured pit-and-fissure sealants containing fluoride (Teethmate F-1, TF; UltraSea-1 XT, US) or not containing fluoride (Teethmate A, TA)- and glass ionomer liner/base containing fluoride (Vitrebond, VB) against oral bacteria in vivo. VB inhibited the growth of S. mutans, S. oralis and L. casei aerobically and anaerobically, and TA and US inhibited the growth of only S. mutans aerobically. The numbers of adherent cells mediated by insoluble glucan for all materials were lower than that for the control tooth. The numbers of adhesional cells not mediated by insoluble glucan were larger than that for the control tooth. VB showed the highest concentration of fluoride released throughout the four-week observation period, and had the highest pH value. In this study, VB showed superior antibacterial action and fluoride-release compared with the other three materials.
authors.affiliation: Department of Pediatric Dentistry, Hiroshima University School of Dentistry.
authors.forename: K
authors.initials: K
authors.lastname: Kozai
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: N
authors.initials: N
authors.lastname: Nagasaka
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D001422:Bacterial Adhesion / Q000187:drug effects*; D002327:Cariostatic Agents / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003188:Composite Resins; D003736:Dental Cavity Lining; D005459:Fluorides / Q000737:chemistry / Q000494:pharmacology*; D005899:Glass Ionomer Cements / Q000737:chemistry; D005936:Glucans / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007780:Lacticaseibacillus casei / Q000187:drug effects* / Q000254:growth & development; D010895:Pit and Fissure Sealants / Q000737:chemistry; D011135:Polysaccharides, Bacterial / Q000378:metabolism; D012995:Solubility; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D019533:Streptococcus oralis / Q000187:drug effects* / Q000254:growth & development
chemical_list: D002327:Cariostatic Agents; D003188:Composite Resins; D005899:Glass Ionomer Cements; D005936:Glucans; D010895:Pit and Fissure Sealants; D011135:Polysaccharides, Bacterial; C106663:Ultra Seal XT; C099291:teethmate-FTM; C067790:Vitrabond; D005459:Fluorides