title: Demographic, morphological, and clinical characteristics of 1289 patients with brain arteriovenous malformation.
abstract: OBJECTIVE
  The purpose of this study was to assess demographic, clinical, and morphological characteristics of patients with brain arteriovenous malformations (AVMs).
  
  
  METHODS
  Prospectively collected data of 1289 consecutive AVM patients from 3 independent databases (1 multicenter [Berlin/Paris/Middle and Far East, n=662] and 2 single centers [New York, n=337, and Toronto, n=290]) were analyzed. The variables assessed were age at diagnosis, sex, AVM size, AVM drainage pattern, AVM location in functionally important brain areas ("eloquence"), and type of presentation (hemorrhage, seizure, chronic headache, or focal neurologic deficit). Comparisons were made by ANOVA, contingency tables, and log-linear models.
  
  
  RESULTS
  Overall, mean age at diagnosis was 31.2 years (95% CI 30.2 to 32.2 years), and 45% of the patients were female (95% CI 42% to 47%). AVM maximum diameter was <3 cm in 38% (95% CI 35% to 41%). Deep venous drainage was present in 55% (95% CI 52% to 59%). An eloquent AVM location was described in 71% (95% CI 69% to 74%). AVM hemorrhage occurred in 53% (95% CI 51% to 56%). Generalized or focal seizures were described in 30% (95% CI 27% to 33%) and 10% (95% CI 8% to 12%), respectively. Chronic headache was recorded in 14% (95% CI 12% to 16%). Persistent neurological deficits were found in 7% (95% CI 6% to 9%), and progressive neurological deficits in 5% (95% CI 4% to 6%). Significant differences between centers were found for age (P<0.001), sex (P=0.04), eloquence (P=0.04), size (P<0.001), hemorrhage (P=0.006), persistent neurological deficit (P<0.001), and reversible neurological deficit (P=0.013). The intercenter difference found for hemorrhage frequency did not remain after adjustment for AVM size.
  
  
  CONCLUSIONS
  Baseline characteristics differed considerably between centers. The differences found in patient age and AVM size may be explained by center-specific referral patterns and the influence of access to treatment resources, whereas those found for other characteristics may be attributable to center-specific definitions. Analysis of natural history data from tertiary referral center databases may be improved by consistent definitions applicable to the entire population of AVM patients.
authors.affiliation: Berufsgenossenschaftliche Kliniken der Stadt Halle, Bergmannstrost, Halle/Saale, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hofmeister
authors.forename: C
authors.initials: C
authors.lastname: Stapf
authors.forename: A
authors.initials: A
authors.lastname: Hartmann
authors.forename: R R
authors.initials: RR
authors.lastname: Sciacca
authors.forename: U
authors.initials: U
authors.lastname: Mansmann
authors.forename: K
authors.initials: K
authors.lastname: terBrugge
authors.forename: P
authors.initials: P
authors.lastname: Lasjaunias
authors.forename: J P
authors.initials: JP
authors.lastname: Mohr
authors.forename: H
authors.initials: H
authors.lastname: Mast
authors.forename: J
authors.initials: J
authors.lastname: Meisel
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001925:Brain Damage, Chronic / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D004827:Epilepsy / Q000209:etiology; D005260:Female; D014943:Global Health; D006261:Headache / Q000209:etiology; D006297:Health Services Accessibility; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012017:Referral and Consultation; D017678:Sex Distribution