title: [Pharmaceutical contribution to the non specific challenge in bronchial provocation tests].
abstract: Aerosols of methacholine chloride are used in inhalation tests to measure non-specific bronchial responsiveness. Inhalation challenge solutions are not commercially available neither by pharmaceutical industry nor in France by the PCH-APHP. To reply to doctor's request, dilute concentrations of methacholine must be prepared properly in order to protect the patient and to assure doctor of test reproductibility. Osmolarity, pH and degradation of different dilute concentration of methacholine chloride have been compared with two diluents. This study allowed us to validate our preparation of solutions.
authors.affiliation: Pharmacie Centrale, CHRU de Lille, 2, avenue Oscar Lambret F 59037 Lille Cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Bonte
authors.forename: C
authors.initials: C
authors.lastname: Berneron
authors.forename: M
authors.initials: M
authors.lastname: Torck
authors.forename: E
authors.initials: E
authors.lastname: Toguyeni
authors.forename: E
authors.initials: E
authors.lastname: Mornay
mesh_terms: D000280:Administration, Inhalation; D016535:Bronchial Hyperreactivity / Q000139:chemically induced* / Q000473:pathology; D001985:Bronchial Provocation Tests; D016085:Bronchoconstrictor Agents / Q000008:administration & dosage / Q000737:chemistry; D004339:Drug Compounding; D016210:Methacholine Chloride / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride