Syndecans and the lymphoid system.
Syndecans, transmembrane proteoglycans, play an important role in cell-matrix and cell-cell interactions, as well as modulators in receptor activation. These functions are partly non-specific and related to the heparan sulfate chains attached to the ectodomain, and partly specific due to the transmembrane and cytoplasmic domains of the core protein. In hemopoietic cells syndecan-1 is expressed only in B cells at certain differentiation stages (pre-B and plasma cells). In lymphoproliferative conditions this selective expression is retained in myelomas/plasmacytomas and other lymphoplasmacytic NHL subtypes, and primary effusional lymphomas. It is probably gained in B-CLL, and lost in other NHLs of pre- or post-follicular origin. It is concluded from these empiric results that the expression of syndecan is essential for some NHLs, probably ensuring the required connections to the microenvironment. From a diagnostic point of view, syndecan-1 is a very useful phenotypic marker to indentify cells with plasmacytic differentiation. The importance of syndecan expression in CLL and Hodgkin's lymphoma still requires further studies.
Kopper
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1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Budapest, Hungary. kopper@korb1.sote.hu
Sebestyén
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D051722:ADAM Proteins; D000072199:ADAM12 Protein; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism; D014408:Biomarkers, Tumor; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D015850:Interleukin-6 / Q000494:pharmacology; D008221:Lymphoid Tissue / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000378:metabolism / Q000473:pathology; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism; D008666:Metalloendopeptidases / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000502:physiology; D010954:Plasmacytoma / Q000378:metabolism / Q000473:pathology; D011487:Protein Conformation; D011509:Proteoglycans / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018121:Receptors, Cytokine / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015398:Signal Transduction; D053668:Syndecan-1; D053667:Syndecans; D014162:Transfection
D014408:Biomarkers, Tumor; D016207:Cytokines; D015850:Interleukin-6; D046911:Macromolecular Substances; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D011509:Proteoglycans; D018121:Receptors, Cytokine; D011993:Recombinant Fusion Proteins; C508241:SDC1 protein, human; D053668:Syndecan-1; D053667:Syndecans; D051722:ADAM Proteins; D000072199:ADAM12 Protein; C000606480:ADAM12 protein, human; D008666:Metalloendopeptidases