title: Antimicrobial and radical modulation activity of AV-07, a poly-herbal formula.
abstract: An extract of AV-07 was investigated for various biological activities. Pretreatment of mice with the AV-07 extract significantly protected them from lethal infection with E. coli. ESR spectroscopy showed that the extract produced radicals under alkaline conditions and enhanced the radical intensity of sodium ascorbate, suggesting its pro-oxidant action at higher concentrations. The extract effectively scavenged superoxide anion, produced by hypoxanthine-xanthine oxidase reaction and hydroxyl radical, produced by Fenton reaction. These data demonstrate that AV-07 extract contains various bioactive substances, suggesting its medicinal efficacy.
authors.affiliation: Analysis Center, School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Sakagami
authors.forename: Y
authors.initials: Y
authors.lastname: Ida
authors.forename: N
authors.initials: N
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Fujimaki
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Kanbara
authors.forename: M
authors.initials: M
authors.lastname: Gupta
authors.forename: D N
authors.initials: DN
authors.lastname: Sarma
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D004927:Escherichia coli Infections / Q000401:mortality / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D015996:Survival Rate
chemical_list: D000890:Anti-Infective Agents; D016166:Free Radical Scavengers; D010936:Plant Extracts; C412545:herbal formula AV-07