title: Partial trisomy of chromosome 10 inherited from a carrier father.
abstract: Partial trisomy of chromosome 10q is a very rare condition with only four cases having been reported int he literature. This report describes a neonate with symmetric growth retardation and multiple dysmorphic features, in whom G-banded chromosomal analysis revealed a partial trisomy of chromosome 10q (q2.4-q ter). The father was diagnosed as a carrier of a balanced translocation with a karyotype of 46, XY t(10.3) (q2.4L : pter). In patients with a bad obstetric history, genetic counselling prior to a new conception cna aid in early prenatal diagnosis of fetuses with recurrent chromosomal abnormalities by means of fetal tissue sampling.
authors.affiliation: Mediscan Systems Prenatal Diagnosis & Fetal Therapy Centre, Madras.
authors.forename: S
authors.initials: S
authors.lastname: Suresh
authors.forename: I
authors.initials: I
authors.lastname: Suresh
authors.forename: P
authors.initials: P
authors.lastname: Lakshminarayana
authors.forename: G
authors.initials: G
authors.lastname: Jabeen
authors.forename: K
authors.initials: K
authors.lastname: Rajesh
mesh_terms: D000328:Adult; D002871:Chromosome Banding; D002879:Chromosomes, Human, Pair 10; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000235:genetics*; D006580:Genetic Carrier Screening; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D010375:Pedigree; D011247:Pregnancy; D014314:Trisomy; D016216:Ultrasonography, Prenatal