title: Neurologic manifestations of cerebral air embolism as a complication of central venous catheterization.
abstract: OBJECTIVE, PATIENTS, AND METHODS: A severe case of cerebral air embolism after unintentional central venous catheter disconnection was the impetus for a systematic literature review (1975-1998) of the clinical features of 26 patients (including our patient) with cerebral air embolism resulting from central venous catheter complications.
  
  
  RESULTS
  The jugular vein had been punctured in eight patients and the subclavian vein, in 12 patients. Embolism occurred in four patients during insertion, in 14 patients during unintentional disconnection, and in eight patients after removal and other procedures. The total mortality rate was 23%. Two types of neurologic manifestations may be distinguished: group A (n = 14) presented with encephalopathic features leading to a high mortality rate (36%); and group B (n = 12) presented with focal cerebral lesions resulting in hemiparesis or hemianopia affecting mostly the right hemisphere, with a mortality rate as high as 8%. In 75% of patients, an early computed tomography indicated air bubbles, proving cerebral air embolism. Hyperbaric oxygen therapy was performed in only three patients (12%). A cardiac defect, such as a patent foramen ovale was considered the route of right to left shunting in 6 of 15 patients (40%). More often, a pulmonary shunt was assumed (9 of 15 patients; 60%). For the remainder, data were not available.
  
  
  CONCLUSIONS
  When caring for critically ill patients needing central venous catheterization, nursing staff and physicians should be aware of this potentially lethal complication.
authors.affiliation: Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: J G
authors.initials: JG
authors.lastname: Heckmann
authors.forename: C J
authors.initials: CJ
authors.lastname: Lang
authors.forename: K
authors.initials: K
authors.lastname: Kindler
authors.forename: W
authors.initials: W
authors.lastname: Huk
authors.forename: F J
authors.initials: FJ
authors.lastname: Erbguth
authors.forename: B
authors.initials: B
authors.lastname: Neundörfer
mesh_terms: D000368:Aged; D000405:Akinetic Mutism / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D002405:Catheterization, Central Venous; D001026:Coronary Artery Bypass; D004618:Embolism, Air / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D006429:Hemiplegia / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D017052:Hospital Mortality; D006801:Humans; D006931:Hyperbaric Oxygenation; D020766:Intracranial Embolism / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality; D007601:Jugular Veins; D008297:Male; D009460:Neurologic Examination; D013350:Subclavian Vein; D015996:Survival Rate; D014057:Tomography, X-Ray Computed