title: Semi-invasive allergic aspergillosis of the paranasal sinuses.
abstract: Aspergillosis of the nose and paranasal sinuses has classically been divided into four types: allergic, non-invasive, invasive and fulminant. Recent reports have suggested that a semi-invasive form with bone destruction and erosion, but without fungal tissue invasion, may occur. We present a case of allergic non-invasive aspergillosis of the paranasal sinuses with associated bone destruction extending into the orbit and anterior cranial fossa, in a non-immunocompromised patient. Surgical debridement combined with a prolonged course of oral itraconazole has resulted in long-term resolution with no evidence of recurrence of disease five years later.
authors.affiliation: Department of Otolaryngology, Guy's Hospital, London, UK.
authors.forename: M F
authors.initials: MF
authors.lastname: Oyarzabal
authors.forename: E B
authors.initials: EB
authors.lastname: Chevretton
authors.forename: R J
authors.initials: RJ
authors.lastname: Hay
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000175:diagnosis* / Q000628:therapy; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010254:Paranasal Sinus Diseases / Q000175:diagnosis* / Q000628:therapy; D014057:Tomography, X-Ray Computed