title: Antinociceptive effect of cilnidipine, a novel N-type calcium channel antagonist.
abstract: We investigated the antinociceptic effects of cilnidipine, a dihydropyridine derivative which acts on both L- and N-type voltage-dependent calcium channels, in mice. Intrathecally injected cilnidipine showed significant analgesic effect in formalin test. Cilnidipine significantly suppressed N-type currents in dorsal root ganglion (DRG) cells. Our findings apparently support the idea that cilnidipine attenuates synaptic neurotransmission by inhibiting N-type calcium channels in DRG neurons.
authors.affiliation: Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryomachi, Aobaku, 980-8575, Sendai, Japan. mmura@mail.cc.tohoku.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: O
authors.initials: O
authors.lastname: Nakagawasai
authors.forename: S
authors.initials: S
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Hosono
authors.forename: S
authors.initials: S
authors.lastname: Hozumi
authors.forename: A
authors.initials: A
authors.lastname: Esashi
authors.forename: R
authors.initials: R
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Sasano
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: K
authors.initials: K
authors.lastname: Tan-no
authors.forename: T
authors.initials: T
authors.lastname: Tadano
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: K
authors.initials: K
authors.lastname: Kisara
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020864:Calcium Channels, N-Type / Q000235:genetics / Q000378:metabolism*; D004095:Dihydropyridines / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects; D015870:Gene Expression / Q000502:physiology; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D009529:Nicardipine / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects*; D012333:RNA, Messenger / Q000032:analysis; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D020864:Calcium Channels, N-Type; D004095:Dihydropyridines; D012333:RNA, Messenger; C065927:cilnidipine; D009529:Nicardipine