title: Anti-inflammatory, antioxidant and antimicrobial activity of Ophthacare brand, an herbal eye drops.
abstract: In the present study, the herbal preparation of Ophthacare brand eye drops was investigated for its anti-inflammatory, antioxidant and antimicrobial activity, using in vivo and in vitro experimental models. Ophthacare brand eye drops exhibited significant anti-inflammatory activity in turpentine liniment-induced ocular inflammation in rabbits. The preparation dose-dependently inhibited ferric chloride-induced lipid peroxidation in vitro and also showed significant antibacterial activity against Escherichia coli and Staphylococcus aureus and antifungal activity against Candida albicans. All these findings suggest that Ophthacare brand eye drops can be used in the treatment of various ophthalmic disorders.
authors.affiliation: Research and Technical Services The Himalaya Drug Co., Makali, Bangalore, India. hdcrd@bgl.vsnl.net.in
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
authors.forename: R
authors.initials: R
authors.lastname: Sundaram
authors.forename: M V
authors.initials: MV
authors.lastname: Venkataranganna
authors.forename: S
authors.initials: S
authors.lastname: Gopumadhavan
authors.forename: N S
authors.initials: NS
authors.lastname: Prakash
authors.forename: H D
authors.initials: HD
authors.lastname: Jayaram
authors.forename: D N
authors.initials: DN
authors.lastname: Sarma
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002849:Chromatography, Gas; D005123:Eye; D005260:Female; D007249:Inflammation; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions / Q000032:analysis*; D008517:Phytotherapy; D011817:Rabbits; D051381:Rats; D014425:Turpentine
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D009883:Ophthalmic Solutions; D014425:Turpentine