title: Use of antibiotics in penetrating craniocerebral injuries. "Infection in Neurosurgery" Working Party of British Society for Antimicrobial Chemotherapy.
abstract: The Working Party was instituted to investigate the rationale of prophylactic and therapeutic antibiotic use in penetrating craniocerebral injuries (PCCI), and to make recommendations for current practice. A systematic review of papers on civilian and military PCCI over the past 25 and 50 years, respectively, was done via electronic databases and secondary sources, and data were evaluated. Guidelines on the removal of indriven bone or metal fragments only if further neural damage can be avoided were supported. However, no publications were identified where the data on infection or its treatment and prevention were complete or satisfactorily derived, and no controlled trials have been published. All studies were retrospective or anecdotal. Working Party recommendations are based on the data available and the professional experience and knowledge of the members. Broad-spectrum antibiotic prophylaxis is recommended for both military and civilian PCCI, Including those due to sports or recreational injuries.
authors.affiliation: Division of Microbiology and Infectious Diseases, University of Nottingham Faculty of Medicine and Health Sciences, UK. roger.bayston@nottingham.ac.uk
authors.forename: R
authors.initials: R
authors.lastname: Bayston
authors.forename: J
authors.initials: J
authors.lastname: de Louvois
authors.forename: E M
authors.initials: EM
authors.lastname: Brown
authors.forename: R A
authors.initials: RA
authors.lastname: Johnston
authors.forename: P
authors.initials: P
authors.lastname: Lees
authors.forename: I K
authors.initials: IK
authors.lastname: Pople
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000209:etiology* / Q000517:prevention & control*; D020197:Head Injuries, Penetrating / Q000150:complications* / Q000628:therapy; D006801:Humans; D014948:Wounds, Gunshot / Q000150:complications / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents