title: Feasibility and prognostic value of dobutamine-atropine stress echocardiography early in unstable angina.
abstract: OBJECTIVE
  Because unstable angina has always been considered a contraindication for dobutamine-atropine stress echocardiography (DSE), the role of dobutamine-atropine stress echocardiography in unstable angina is unknown. Our aim was to assess the safety and prognostic value of dobutamine-atropine stress echocardiography in unstable angina.
  
  
  METHODS
  One hundred and thirty-two patients were studied (mean age 64+/-12 years, 29 women). Dobutamine-atropine stress echocardiography was performed on the third day after hospital admission. End-points were unstable angina, myocardial infarction or cardiac death at 1 year follow-up.
  
  
  RESULTS
  No major complications occurred during dobutamine-atropine stress echocardiography. Ninety-six (78%) patients were on beta-blocker therapy during the test; mean maximum heart rate achieved was 106+/-23 beats x min(-1). Nine of the 21 patients (43%) with a positive dobutamine-atropine stress echocardiography presented cardiac events during follow-up: two patients died, one had a myocardial infarction and six had recurrent class III-IV angina. Among 80 patients with negative dobutamine-atropine stress echocardiography, one (1%) had myocardial infarction and six patients (7.5%) had recurrent angina. Event-free survival after 1 year for patients with a negative dobutamine-atropine stress echocardiography for ischaemia was 91% compared to 57% for those with a positive dobutamine-atropine stress echocardiography (P<0. 0001). Left ventricular dysfunction (P=0.01), prior myocardial infarction (P=0.03) and a positive dobutamine-atropine stress echocardiography (P=0.004) were independent predictors of cardiac events during follow-up.
  
  
  CONCLUSIONS
  Dobutamine-atropine stress echocardiography is safe in unstable angina if it is performed when patients remain asymptomatic for at least 48 h. A negative dobutamine-atropine stress echocardiogram for ischaemia predicts a good prognosis in medically treated patients with unstable angina and may allow their early discharge from hospital. Good prognostic information was obtained despite the use of beta-blockers and low heart rates during dobutamine-atropine stress echocardiography.
authors.affiliation: Cardiovascular Institute, University of Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Sitges
authors.forename: C
authors.initials: C
authors.lastname: Paré
authors.forename: M
authors.initials: M
authors.lastname: Azqueta
authors.forename: X
authors.initials: X
authors.lastname: Bosch
authors.forename: F
authors.initials: F
authors.lastname: Miranda-Guardiola
authors.forename: M
authors.initials: M
authors.lastname: Velamazán
authors.forename: J
authors.initials: J
authors.lastname: Magriñá
authors.forename: G
authors.initials: G
authors.lastname: Sanz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001285:Atropine / Q000008:administration & dosage; D004280:Dobutamine / Q000008:administration & dosage; D004452:Echocardiography; D004562:Electrocardiography; D005080:Exercise Test; D005240:Feasibility Studies; D005260:Female; D006339:Heart Rate; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D004280:Dobutamine; D001285:Atropine