Cytotoxic triterpenes from Crataegus pinnatifida.
Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.
Min
B S
BS
College of Pharmacy, Chungnam National University, Taejon, Korea.
Kim
Y H
YH
Lee
S M
SM
Jung
H J
HJ
Lee
J S
JS
Na
M K
MK
Lee
C O
CO
Lee
J P
JP
Bae
K
K
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000097245:Ursolic Acid
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D000097245:Ursolic Acid; C412949:3-oxo-ursolic acid; C013330:uvaol