[Causative agents for lung carcinogenesis].
Lung cancer is a leading cause of malignancy-related death in Japan, and its incidence is still rising steeply. Various factors, including cigarette smoking, asbestos, and diet, have been reported to correlate with the development of lung cancer. Of these factors, cigarette smoking is believed as the major carcinogen for lung cancer. Recent studies indicate that cigarette smoke carcinogens cause genetic damages at both oncogenes(K-ras) and tumor suppressor genes(p53) of lung cancer, and hence initiate and promote the development of lung cancer. This article reviews recent advances in the molecular mechanisms of lung cancer carcinogenesis.
Yano
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Third Department of Internal Medicine, University of Tokushima, School of Medicine.
Sone
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D000397:Air Pollution / Q000009:adverse effects; D001194:Asbestos / Q000009:adverse effects; D002791:Cholesterol, Dietary / Q000009:adverse effects; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*
D002791:Cholesterol, Dietary; D001194:Asbestos