Paradoxical increase of tyrosine hydroxylase-immunoreactive retinopetal fibers in the weaver mouse.
Weaver mice undergo apoptosis of the granule cell precursors of the cerebellum and nonapoptotic death of mesencephalic dopaminergic cells during post-natal development. In contrast, the number of retinal dopaminergic cells was transiently increased in weaver compared to control mice [C. Savy, E. Martin-Martinelli, A. Simon, C. Duyckaerts, C. Verney, C. Adelbrecht, R. Raisman-Vozari, J. Nguyen-Legros, Altered development of dopaminergic cells in the retina of weaver mice, J. Comp. Neurol. 1999;412:656-668]. While re-examining the retinas, we observed, in the nerve fiber layer, retinopetal tyrosine hydroxylase-immunoreactive fibers, which were dramatically increased in number throughout development and adulthood in the weaver compared to control mice.
Simon
A
A
Laboratoire de Neurocytologie Oculaire, INSERM U86, 15 rue de l'Ecole de Médecine, 75270 Cedex 06, Paris, France.
Savy
C
C
Martin-Martinelli
E
E
Douhou
A
A
Frédéric
F
F
Verney
C
C
Nguyen-Legros
J
J
Raisman-Vozari
R
R
D000818:Animals; D000906:Antibodies; D017209:Apoptosis / Q000502:physiology*; D004195:Disease Models, Animal; D005838:Genotype; D051379:Mice; D008818:Mice, Neurologic Mutants; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000201:enzymology / Q000648:ultrastructure; D010300:Parkinson Disease / Q000201:enzymology / Q000235:genetics; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000201:enzymology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis* / Q000276:immunology
D000906:Antibodies; D014446:Tyrosine 3-Monooxygenase