title: Clastogenic effects of zinc chloride on human peripheral blood leucocytes in vitro.
abstract: The clastogenic effects of three different concentrations of zinc chloride on human peripheral blood leucocytes were studied in vitro. The highest concentration (1.5 x 10(-3) M) was lethal after 48 and 72 h of culture and no blast cells were formed. The two lower concentrations (3.0 x 10(-4) M and 3.0 x 10(-5) M) significantly reduced the frequency of cell division, induced chromatid breaks and damaged cells in frequencies significantly higher than in control experiments maintained in sodium chloride and in distilled water.
authors.affiliation: Department of Pathology, Vivekananda Institute of Medical Sciences, Calcutta, India.
authors.forename: M
authors.initials: M
authors.lastname: Santra
authors.forename: G
authors.initials: G
authors.lastname: Talukder
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000397:Air Pollution; D002455:Cell Division / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007194:India; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009153:Mutagens; D011123:Polyploidy; D012965:Sodium Chloride / Q000494:pharmacology; D017967:Zinc Compounds / Q000494:pharmacology*
chemical_list: D002712:Chlorides; D009153:Mutagens; D017967:Zinc Compounds; D012965:Sodium Chloride; C016837:zinc chloride