title: Role of hepatic lipogenesis in the susceptibility to fatty liver in the goose (Anser anser).
abstract: In response to overfeeding, the Landes goose develops a fatty liver that is twice as large as that of the Poland goose, despite similar food intake. The role of hepatic lipogenesis in the genetic susceptibility to fatty liver was assessed in male overfed geese of the two breeds. For a similar hepatic protein content, total activities of malic enzyme, glucose-6-phosphate dehydrogenase, acetyl-Coa-carboxylase and fatty acid synthase, and specific activity and mRNA level of malic enzyme were about two-fold higher in the Landes goose. In the Poland goose, the weight of the fatty liver was correlated positively with the specific activity of ME and the VLDL concentration, which was not the case in the Landes breed. These results show that: (1) hepatic lipogenesis remains very active until the end of the overfeeding period; (2) the pentose-phosphate pathway may function in birds, contrary to what is assumed usually; (3) the level of hepatic lipogenesis is a major factor in the susceptibility to hepatic steatosis in different breeds of geese; and (4) ME activity may be a limiting factor of lipid synthesis in the less susceptible Poland breed.
authors.affiliation: INRA, Station de Recherches Porcines, L'Hermitage, France.
authors.forename: J
authors.initials: J
authors.lastname: Mourot
authors.forename: G
authors.initials: G
authors.lastname: Guy
authors.forename: S
authors.initials: S
authors.lastname: Lagarrigue
authors.forename: P
authors.initials: P
authors.lastname: Peiniau
authors.forename: D
authors.initials: D
authors.lastname: Hermier
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D001715:Bird Diseases / Q000378:metabolism*; D001823:Body Composition; D004198:Disease Susceptibility; D064429:Fatty Acid Synthases / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism / Q000662:veterinary*; D005777:Geese / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008079:Lipoproteins, VLDL / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male
chemical_list: D008079:Lipoproteins, VLDL; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase