Megestrol-induced clinical adrenal insufficiency.
OBJECTIVE
To describe a case of megestrol-induced adrenal insufficiency.


METHODS
A patient who received megestrol and then developed pituitary-adrenal axis abnormalities is described. The literature is reviewed.


RESULTS
The patient developed megestrol-induced Cushingoid features. She developed adrenal insufficiency when megestrol was stopped.


CONCLUSIONS
Megestrol can induce alterations of the pituitary-adrenal axis in some patients. It is important to consider a diagnosis of adrenal insufficiency in patients with symptoms of fatigue, hypotension, and asthenia who have been treated with megestrol.
Goodman
A
A
Harvard Medical School Massachusetts General Hospital, Department of Obstetrics and Gynecology, Boston 02114, USA.
Cagliero
E
E
D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000188:drug therapy; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008535:Megestrol / Q000009:adverse effects* / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D008535:Megestrol; D011241:Prednisone