Pseudoscleroderma associated with lung cancer: correlation of collagen type I and connective tissue growth factor gene expression.
Pseudoscleroderma as a paraneoplastic syndrome is a rare disease. We report here a patient with lung cancer (undifferentiated squamous cell carcinoma), who developed acrosclerosis. Using in situ hybridization, marked expression of alpha1(I)-collagen and connective tissue growth factor (CTGF) mRNA was found in fibroblasts scattered throughout the dermis. However, transforming growth factor (TGF)-beta1 expression was not detected. The pattern of CTGF gene expression and collagen synthesis was similar to that in systemic scleroderma. The absence of TGF-beta1 mRNA could indicate that tumour-derived factors induce the expression of CTGF.
Querfeld
C
C
Department of Dermatology, University of Köln, Klinik und Poliklinik für Dermatologie und Venerologie, D-50924 Köln, Germany.
Sollberg
S
S
Huerkamp
C
C
Eckes
B
B
Krieg
T
T
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003094:Collagen / Q000235:genetics; D055513:Connective Tissue Growth Factor; D005260:Female; D015870:Gene Expression; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics; D036341:Intercellular Signaling Peptides and Proteins; D008175:Lung Neoplasms / Q000150:complications*; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000209:etiology* / Q000378:metabolism
C526317:CCN2 protein, human; D006133:Growth Substances; D017874:Immediate-Early Proteins; D036341:Intercellular Signaling Peptides and Proteins; D055513:Connective Tissue Growth Factor; D003094:Collagen