title: A comparative clinical evaluation of econazole nitrate, miconazole, and nystatin in the treatment of vaginal candidiasis.
abstract: A controlled triple open clinical study on three vaginal tablets--Econazole nitrate, Miconazole and Nystatin, was carried out. Seventy-five patients, aged between 18 and 45 years, presenting with mycologically proven cases of vaginal candidiasis, met certain set criteria and were admitted into the study. Twenty-five patients were randomly assigned to each of the three treatment groups. Results of the study showed that at the 4th week after treatment, Econazole was comparable in antifungal action to Miconazole (x2 = 0.2128; p > 0.05) but significantly more antifungal than Nystatin (x2 = 8.8540; P < 0.05), although the overall clinicomycological assessment of the drugs showed no significant difference in their ratings (F = 21.34; P > 0.05).
authors.affiliation: Medical Microbiology Department, Usman Danfodio University Teaching Hospital, Sokoto.
authors.forename: F E
authors.initials: FE
authors.lastname: Emele
authors.forename: A A
authors.initials: AA
authors.lastname: Fadahunsi
authors.forename: C E
authors.initials: CE
authors.lastname: Anyiwo
authors.forename: O
authors.initials: O
authors.lastname: Ogunleye
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000145:classification / Q000188:drug therapy* / Q000382:microbiology; D004464:Econazole / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008825:Miconazole / Q000627:therapeutic use*; D008875:Middle Aged; D009549:Nigeria; D009761:Nystatin / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009761:Nystatin; D004464:Econazole; D008825:Miconazole