Endothelin-1 stimulates sphingosine kinase in human hepatic stellate cells. A novel role for sphingosine-1-P as a mediator of growth inhibition.
Gallois
C
C
INSERM U99, Hôpital Henri Mondor, Créteil, France.
Davaille
J
J
Habib
A
A
Mallat
A
A
Tao
J
J
Levade
T
T
Lotersztajn
S
S
D002455:Cell Division / Q000502:physiology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D019332:Endothelin-1 / Q000502:physiology*; D004789:Enzyme Activation; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology; D000099157:Sphingosine Kinase
D016861:Cyclooxygenase Inhibitors; D019332:Endothelin-1; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor); D013110:Sphingosine; D000099157:Sphingosine Kinase; C060506:sphingosine 1-phosphate