Solid-phase oligosaccharide synthesis: preparation of complex structures using a novel linker and different glycosylating agents.
[formula: see text] A beta-(1-->4)-linked trisaccharide was prepared in 53% yield on a polymer support using glycosyl phosphates and released by cross-metathesis of a novel linker to reveal the anomeric n-pentenyl glycoside. Heptasaccharide 33 was prepared in 9% yield in 14 steps.
Andrade
R B
RB
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Plante
O J
OJ
Melean
L G
LG
Seeberger
P H
PH
D002240:Carbohydrate Sequence; D006031:Glycosylation; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis*
D009844:Oligosaccharides