[Validation of a method to inactivate fentanyl in the used devices of Durogesic].
A recent literature study has shown that after 3 days of use of a transdermic patch of fentanyl (Durogésic(R)), there was such an amount of drug remaining that may make its excessive use possible. First of all, we have developed a fentanyl assay by a spectrophotometric method and then, the remaining amount of fentanyl was determined in 29 used patches. This study has shown that a mean of 22% of fentanyl remained in the used patches, each original content astounded. Then, we have determined an easy and feasible method in a chemist's shop allowing inactivation of fentanyl in the used patches and so preventing its diversion.
Zambaux
M
M
Faculté de Pharmacie, 5, rue Albert Lebrun, F 54000 Nancy Cedex, France.
Bonneaux
F
F
Du
H
H
Labrude
P
P
D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000032:analysis*; D005283:Fentanyl / Q000008:administration & dosage / Q000032:analysis*; D019966:Substance-Related Disorders / Q000517:prevention & control
D000701:Analgesics, Opioid; D005283:Fentanyl