Targets of drug action.
This article considers early work from the author's laboratory on muscarinic receptor specificity, subtypes, and conformational variability, with the use of nuclear magnetic resonance in pharmacology and the conformational variants of dihydrofolate reductase and general questions of receptors. It also considers some current approaches to drug development and receptor function, particularly as influenced by increasing knowledge of three-dimensional structure of receptors.
Burgen
A S
AS
Department of Pharmacology, University of Cambridge, United Kingdom. asvb@cam.ac.uk
D000818:Animals; D015195:Drug Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011487:Protein Conformation; D011976:Receptors, Muscarinic / Q000737:chemistry / Q000187:drug effects*; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry
D011976:Receptors, Muscarinic; D013762:Tetrahydrofolate Dehydrogenase