Kinetic resolution and isomerization of 2,5-disubstituted pyrrolines.
The efficient kinetic resolution of 2,5-disubstituted pyrrolines was accomplished by employing hydrosilylation with a chiral catalyst, (EBTHI)TiF2 (EBTHI = ethylenebis(tetrahydroindenyl)). An interesting isomerization reaction of the cyclic imines catalyzed by the same chiral catalyst was also discovered.
Yun
J
J
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Buchwald
S L
SL
D002621:Chemistry / Q000379:methods*; D007097:Imines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D007097:Imines; D011758:Pyrroles; C013231:pyrroline