title: Cutaneous fixed drug eruption to paclitaxel; a case report.
abstract: The aim of this report was to investigate an adverse effect of paclitaxel. Cutaneous fixed drug eruption against paclitaxel--which is rarely seen--is explained. A 70-year-old caucasian woman experienced three operations for ovarian carcinoma and finally a paclitaxel-based chemotherapy regimen was initiated as adjuvant chemotherapy. Following the administration of the first dose of paclitaxel, the patient had a cutaneous reaction that was clinically consistent with "fixed drug eruption". Lesions regressed with a topical steroid dressing. Histopathological examination of the lesion confirmed clinical diagnosis. It is interesting that such a reaction could occur despite the use of premedication with systemic corticosteroid antihistaminic prophylaxis yet heal rapidly with topical corticosteroid therapy. Thus we recommend careful observation for cutaneous side-effects in patients who receive paclitaxel or other taxanes, even with premedication prophylaxis.
authors.affiliation: Hacettepe University, Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Baykal
authors.forename: E
authors.initials: E
authors.lastname: Erkek
authors.forename: E
authors.initials: E
authors.lastname: Tutar
authors.forename: K
authors.initials: K
authors.lastname: Yüce
authors.forename: A
authors.initials: A
authors.lastname: Ayhan
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000009:adverse effects*; D001707:Biopsy, Needle; D017024:Chemotherapy, Adjuvant; D003875:Drug Eruptions / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel