Detailed allelic loss mapping on 7q32 in nasopharyngeal carcinoma.
OBJECTIVE
The present research group had found high frequency of loss of heterozygosity(LOH) of D7S500-D7S495 on chromosome band 7q32 in nasopharyngeal carcinoma, this study was conducted to further find the deletion region.


METHODS
Higher density of loci on 7q32 in 30 tumors was studied by using microsatellite analysis.


RESULTS
The frequency of LOH was 63.3%. The highest frequency of LOH was identified at the loci of D7S500-D7S509-D7S495, among which a common deletion of D7S509 was found.


CONCLUSIONS
A putative tumor suppressor gene may be present around D7S509.
Tang
X
X
Cancer Research Institute, Hunan Medical University, Changsha, Hunan, 410078 P. R. China. ligy@public.cs.hn.cn
Yang
J
J
Deng
L
L
Jiang
N
N
Zhou
M
M
Zeng
Z
Z
Xie
Y
Y
Tan
G
G
Qiu
Y
Y
Li
G
G
D002897:Chromosomes, Human, Pair 7; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*