Enzymatic selective dehydration and skeleton rearrangement of paclitaxel precursors.
[formula: see text] Enzymatic dehydration reactions to remove selectively the chemically least reactive 13-hydroxyl group of 10-deacetylbaccatin III and its derivatives 2a-c are described. The elimination of the 13-OH takes place with skeleton rearrangement, allowing us to synthesize some interesting diterpenoids in good yields.
Lee
D
D
Department of Chemistry, Pohang University of Science and Technology, Korea.
Kim
M J
MJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D014867:Water; D017239:Paclitaxel