title: Extramedullary plasmacytoma in a horse with ptyalism and dysphagia.
abstract: A Clydesdale mare was examined for weight loss, inappetence, ptyalism, and dysphagia. The main abnormality revealed by serum biochemistry was a marked hyperglobulinemia, and protein electrophoresis revealed a monoclonal gammopathy in the gamma region. The urine was positive for Bence Jones proteins. These findings suggested a plasma cell tumor. The neoplasm could not be located with extensive antemortem examination. At postmortem, neoplastic cells morphologically compatible with plasma cells and positive for equine IgG with imunoperoxidase staining infiltrated the pericardium, mediastinal stromal tissues, adrenal glands, meninges, atrioventricular valves, aorta, abdominal and thoracic fat, and nerves, including the trigeminal nerve. The neoplastic cells invading the cranial nerves were responsible for many of the presenting signs.
authors.affiliation: Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada.
authors.forename: S
authors.initials: S
authors.lastname: McConkey
authors.forename: A
authors.initials: A
authors.lastname: López
authors.forename: J
authors.initials: J
authors.lastname: Pringle
mesh_terms: D000818:Animals; D001536:Bence Jones Protein / Q000652:urine; D001772:Blood Cell Count / Q000662:veterinary; D003680:Deglutition Disorders / Q000209:etiology / Q000662:veterinary; D004586:Electrophoresis / Q000662:veterinary; D017809:Fatal Outcome; D005260:Female; D006651:Histocytochemistry; D006734:Horse Diseases / Q000175:diagnosis* / Q000473:pathology; D006736:Horses; D006942:Hypergammaglobulinemia / Q000662:veterinary; D009380:Neoplasms, Nerve Tissue / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010265:Paraproteinemias / Q000662:veterinary; D010954:Plasmacytoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012472:Salivation; D014276:Trigeminal Nerve / Q000473:pathology; D015431:Weight Loss
chemical_list: D001536:Bence Jones Protein