Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner.
Bicuculline was used to investigate seizure susceptibility in pre- and peripubertal male and female rats exposed prenatally to morphine. Morphine-exposed males showed increased seizure susceptibility at prepubertal and decreased susceptibility at peripubertal ages. There was no difference in seizure susceptibility in morphine-exposed females at either age. Therefore, the present data suggest that males are more vulnerable than females to morphine-induced insults during prenatal brain development.
Schindler
C J
CJ
Department of Neuroscience, Ullmann 111, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, NY 10461, USA. schindle@aecom.yu.edu
Velísková
J
J
Slamberová
R
R
Vathy
I
I
D000367:Age Factors; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001640:Bicuculline; D003292:Convulsants; D004198:Disease Susceptibility; D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced; D012737:Sex Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000701:Analgesics, Opioid; D003292:Convulsants; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D001640:Bicuculline