[Effect of low doses of ionizing radiation on thymus-dependent humoral immune response and the polyclonal activation of B lymphocytes].
The exposure of mice to low dose of gamma-rays (10 cGy, 1 cGy/min) increased thymus-dependent humoral immune response and polyclonal activation of B-cells. Injection of hydroquinone eliminated radiation-induced augmentation of polyclonal response of B-lymphocyte. Thymogen decreased significantly the radiation-induced immunostimulation. The study of the dynamics of primary immune response showed that the period of radiation-induced elevation was followed by the phase of profound reduction of antibody formation. Possible negative consequences of action of low doses of ionizing radiation on immune system is discussed.
Sharetskiĭ
A N
AN
Russian Academy of Medical Sciences, Department of Radiation Immunology, Obninsk, Kaluga region, Russia.
Surinov
B P
BP
Abramova
M R
MR
D000818:Animals; D000917:Antibody Formation / Q000528:radiation effects*; D001402:B-Lymphocytes / Q000276:immunology* / Q000528:radiation effects*; D002417:Cattle; D005720:Gamma Rays; D006386:Hemagglutination Tests; D006873:Hydroquinones / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013950:Thymus Gland / Q000276:immunology* / Q000528:radiation effects*; D014916:Whole-Body Irradiation
D006873:Hydroquinones; D011837:Radiation-Protective Agents; C031927:hydroquinone