On estimating the heterozygosity and polymorphism information content value.
The polymorphism information content (PIC) value is commonly used in genetics as a measure of polymorphism for a marker locus used in linkage analysis. In this communication we have derived the uniformly minimum variance unbiased estimator of PIC along with its exact variance. We have also calculated the exact variance of the maximum likelihood estimator of PIC which is asymptotically an unbiased estimator. In order to find this variance we have derived a recursive formula to calculate the moments of any polynomial in a set of variables that are multinomially distributed.
Shete
S
S
Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, Ohio, 44109-1998, USA.
Tiwari
H
H
Elston
R C
RC
D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D016013:Likelihood Functions; D008957:Models, Genetic; D011110:Polymorphism, Genetic / Q000235:genetics*
D005819:Genetic Markers