title: An adult patient with hypersensitivity to mosquito bites developing mantle cell lymphoma.
abstract: Hypersensitivity to mosquito bites (HMB) has been known to occur exclusively in the first 2 decades of life and is frequently associated with Epstein-Barr virus (EBV) infection and lymphoproliferative diseases. We report here the first adult patient with HMB, a 61-year-old Japanese man who developed mantle cell lymphoma. EBV was detected in the lymph node by polymerase chain reaction and by in situ hybridization. Serum levels of interleukin (IL)-4, IL-6, and IL-10 were markedly increased, and the T-helper cell (Th)1/Th2 balance determined by intracellular cytokine levels was polarized to Th2. These findings suggest that the Th1/Th2 imbalance could partly be involved in the pathogenesis of HMB.
authors.affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. tmori@mc.med.keio.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: S
authors.initials: S
authors.lastname: Kuramochi
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D009033:Culicidae; D016207:Cytokines / Q000097:blood; D006801:Humans; D006967:Hypersensitivity / Q000097:blood* / Q000209:etiology; D007299:Insect Bites and Stings / Q000097:blood / Q000276:immunology*; D007564:Japan; D008198:Lymph Nodes / Q000821:virology; D020522:Lymphoma, Mantle-Cell / Q000097:blood / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets
chemical_list: D016207:Cytokines