A two-step total synthesis of the natural pentacycle trichodimerol, a novel inhibitor of TNF-alpha production.
[formula: see text] Trichodimerol (1) can be synthesized by a remarkable dimerization of the chiral hydroxy dienone 5.
Barnes-Seeman
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Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ
D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D015394:Molecular Structure; D013057:Spectrum Analysis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D001952:Bridged-Ring Compounds; D014409:Tumor Necrosis Factor-alpha; C099299:trichodimerol