title: Studies on inducers of nerve growth factor: synthesis of the cyathin core.
abstract: [formula: see text] Compounds that induce the synthesis of nerve growth factor (NGF) are of interest as alternatives to the administration of the native peptide. We have initiated a program to study the NGF synthesis stimulating activity of the erinacine and scabronine diterpenes. Herein, we report an approach to the core cyathin system by sequential application of an oxidative coupling and [4 + 3] cycloaddition.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville 32611, USA. dwright@chem.ufl.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Wright
authors.forename: C R
authors.initials: CR
authors.lastname: Whitehead
authors.forename: E H
authors.initials: EH
authors.lastname: Sessions
authors.forename: I
authors.initials: I
authors.lastname: Ghiviriga
authors.forename: D A
authors.initials: DA
authors.lastname: Frey
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology; D020932:Nerve Growth Factor / Q000096:biosynthesis* / Q000187:drug effects; D010084:Oxidation-Reduction; D013141:Spiro Compounds / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001572:Benzofurans; D004224:Diterpenes; D013141:Spiro Compounds; C116931:erinacine E; C007179:cyathins; D020932:Nerve Growth Factor