Influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on the synthesis of phosphorothioate oligonucleotides.
Extensive investigations on the influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on stereo-reproducibility of solid phase synthesis of phosphorothioate oligodeoxyribonucleotides via the phosphoramidite approach indicate that the process is stereoreproducible and under inherent process control.
Cheruvallath
Z S
ZS
Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
Sasmor
H
H
Cole
D L
DL
Ravikumar
V T
VT
D002851:Chromatography, High Pressure Liquid; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D013237:Stereoisomerism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
D016376:Oligonucleotides, Antisense; D013873:Thionucleotides