title: Neuropathological findings in the very old. Results from the first 101 brains of a population-based longitudinal study of dementing disorders.
abstract: We report a unique longitudinal epidemiological study of cognitive decline in the elderly population of the city of Cambridge, UK. A population sample of people aged 75 and over was surveyed between 1984-1996 (n = 2,616) and followed 2.4, 6, and 9 years later. CAMDEX diagnostic criteria were used for clinical assessment, and the neuropathological protocol (in 101 cases) was based on the CERAD method, with additional features to allow Braak staging of neurofibrillary pathology. The main findings are of the heterogeneity of lesions to be found in very old populations, and the existence of considerable overlap in the pathologies found in the demented and nondemented. It seems that white matter (ischemic) pallor an amyloid angiopathy, as well as neuritic plaques, neurofibrillary tangles and Lewy body formation are all lesions that increase the likelihood of dementia.
authors.affiliation: Department of Pathology, University of Cambridge, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Xuereb
authors.forename: C
authors.initials: C
authors.lastname: Brayne
authors.forename: C
authors.initials: C
authors.lastname: Dufouil
authors.forename: H
authors.initials: H
authors.lastname: Gertz
authors.forename: C
authors.initials: C
authors.lastname: Wischik
authors.forename: C
authors.initials: C
authors.lastname: Harrington
authors.forename: E
authors.initials: E
authors.lastname: Mukaetova-Ladinska
authors.forename: M A
authors.initials: MA
authors.lastname: McGee
authors.forename: A
authors.initials: A
authors.lastname: O'Sullivan
authors.forename: D
authors.initials: D
authors.lastname: O'Connor
authors.forename: E S
authors.initials: ES
authors.lastname: Paykel
authors.forename: F A
authors.initials: FA
authors.lastname: Huppert
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology*; D003430:Cross-Sectional Studies; D015140:Dementia, Vascular / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D008137:Longitudinal Studies; D008297:Male; D008609:Mental Status Schedule; D016874:Neurofibrillary Tangles / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology; D012737:Sex Factors