title: The cyanobacterium Nodularia PCC 7804, of freshwater origin, produces [L-Har2]nodularin.
abstract: The cyanobacterium Nodularia PCC 7804, an axenic, non gas-vacuolate strain from a freshwater source, produces several metabolites with cyanobacterial hepatotoxin characteristics. The most abundant is a cyclic pentapeptide, [L-Homoarginine2]nodularin. [L-Har2]nodularin is of similar toxicity, in terms of bioassay in vivo, and the inhibition of protein phosphatase-1 in vitro to nodularin, which was present in lesser amounts in the cultures.
authors.affiliation: Department of Biological Sciences, University of Dundee, UK.
authors.forename: K A
authors.initials: KA
authors.lastname: Beattie
authors.forename: K
authors.initials: K
authors.lastname: Kaya
authors.forename: G A
authors.initials: GA
authors.lastname: Codd
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D000458:Cyanobacteria / Q000737:chemistry / Q000378:metabolism*; D000087522:Cyanobacteria Toxins; D005618:Fresh Water; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010456:Peptides, Cyclic / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D014118:Toxins, Biological / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000596:Amino Acids; D000087522:Cyanobacteria Toxins; D010456:Peptides, Cyclic; D014118:Toxins, Biological; C414930:nodularin, Har(2)-