Angiogenesis in embryonic development--a review.
Recent studies, particularly of genetically altered mice, have greatly improved our understanding of the molecular basis underlying the development of the vascular system. Endothelial signalling systems, such as the vascular endothelial growth factor (VEGF)/VEGF receptor system and the angiopoietin/Tie2 system, were identified as central regulators of embryonic angiogenesis. The complex interactions between these and other endothelial signalling systems are beginning to emerge. Placenta (2000), 21, Supplement A, Trophoblast Research, 14, S11-S15.
Breier
G
G
Max-Planck Institut for Physiological and Clinical Research, Laboratory of Molecular and Cellular Biology, Bad Nauheim, Germany. g.breier@kerckhoff.mpg.de
D042683:Angiopoietin-1; D000818:Animals; D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000502:physiology; D016228:Endothelial Growth Factors / Q000235:genetics / Q000502:physiology; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000235:genetics / Q000502:physiology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000235:genetics; D011247:Pregnancy; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology; D042787:Receptor, TIE-2; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D040262:Receptors, Vascular Endothelial Growth Factor; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000099152:Cadherin 5
D042683:Angiopoietin-1; D015703:Antigens, CD; D015820:Cadherins; D016228:Endothelial Growth Factors; D008222:Lymphokines; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases; D042787:Receptor, TIE-2; D017978:Receptors, Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D000099152:Cadherin 5; C467628:Angpt1 protein, mouse; C105373:MEN1 protein, human