Oxidation of polyamines and brain injury.
Several amine oxidases are involved in the metabolism of the natural polyamines putrescine, spermidine, and spermine, and play a role in the regulation of intracellular concentrations, and the elimination of these amines. Since the products of the amine oxidase-catalyzed reactions -- hydrogen peroxide and aminoaldehydes -- are cytotoxic, oxidative degradations of the polyamines have been considered as a cause of apoptotic cell death, among other things in brain injury. Since a generally accepted, unambiguous nomenclature for amine oxidases is missing, considerable confusion exists with regard to the polyamine oxidizing enzymes. Consequently the role of the different amine oxidases in physiological and pathological processes is frequently misunderstood. In the present overview the reactions, which are catalyzed by the different polyamine-oxidizing enzymes are summarized, and their potential role in brain damage is discussed.
Seiler
N
N
CIF INSERM 95-05, Institut de Recherche Contre les Cancers de l'Appareil Digestif, Strasbourg, France. Nikolaus.Seiler@ircad.U-strasbg.fr
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology; D001930:Brain Injuries / Q000097:blood / Q000201:enzymology*; D002417:Cattle; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009474:Neurons / Q000187:drug effects / Q000201:enzymology; D010084:Oxidation-Reduction / Q000187:drug effects; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors / Q000378:metabolism; D011700:Putrescine / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D013095:Spermidine / Q000378:metabolism* / Q000633:toxicity; D013096:Spermine / Q000378:metabolism* / Q000633:toxicity; D000097667:Polyamine Oxidase
D006631:Amine Oxidase (Copper-Containing); D004791:Enzyme Inhibitors; D000587:Oxidoreductases Acting on CH-NH Group Donors; D011700:Putrescine; D013095:Spermidine; D013096:Spermine; D000097667:Polyamine Oxidase