Coma-induced bullae and sweat gland necrosis following clobazam.
Coma-induced bullae and sweat gland necrosis is a rare clinicopathological entity described in association with a variety of aetiopathological conditions all of which have resulted in an impairment of conscious level. We report the first case observed in association with clobazam, used as adjunctive therapy for resistant epilepsy in a 4-year old. The potential underlying mechanisms and previously reported associations are discussed.
Setterfield
J F
JF
Department of Oral Medicine, Department of Paediatrics, Guy's Hospital, and St John's Institute of Dermatology, St Thomas' Hospital, London, UK. j.setterfield@umds.ac.uk
Robinson
R
R
MacDonald
D
D
Calonje
E
E
D014151:Anti-Anxiety Agents / Q000009:adverse effects*; D000927:Anticonvulsants / Q000009:adverse effects*; D001569:Benzodiazepines; D002675:Child, Preschool; D000078306:Clobazam; D003128:Coma / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D009336:Necrosis; D013543:Sweat Gland Diseases / Q000139:chemically induced* / Q000473:pathology; D013545:Sweat Glands / Q000473:pathology*
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D000078306:Clobazam