Normal and altered cytoarchitecture of the inner ear.
Scanning electron microscope gave new insights into real morphology of the inner ear and has enhanced basic research. In fact, during the last twenty years, the cellular system that composes the organ of Corti and the vestibular apparatus has been clearly described by many authors. We now have a better understanding of each cell type and that they have a physiological functioning as ear and vestibular system. In addition, new insights into the damage caused by many drugs, such as aminoglucosides, can be investigated by studying the morphological changes and the reparative process following the injury. Animals such as guinea pigs can be used as ideal models to investigate the alterations in the sensory epithelium of the cochlear and vestibular receptors following ototoxic poisoning.
Serra
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E.N.T. Department, University of Catania, Italy. serra@mbox.unict.it
Grasso
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DL
Cocuzza
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S
Trombetta
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L
la Mantia
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I
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D003051:Cochlea / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D007758:Ear, Inner / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents