title: Relation of biochemical, cytologic, and morphologic parameters to the result of gammagraphy with technetium 99m sestamibi in primary hyperparathyroidism.
abstract: The aim of this study was to analyze the possible relation of biochemical, cytologic, and morphologic parameters to the results of parathyroid gammagraphy with Tc 99m sestamibi in primary hyperparathyroidism. We studied 46 consecutive patients with primary hyperparathyroidism who were undergoing surgery. All the patients were given a preoperative parathyroid gammagraphy with Tc 99m sestamibi and a complete preoperative biochemical study. During the surgical intervention we recorded the weight and size of the pathologic glands to calculate the volume of each. We also determined the percentage of the chief and oxyphil cells in the pathologic glands. Tc 99m sestamibi sensitivity is higher in adenomas (91%) than in hyperplasia (67%) or double adenomas (50%). No relation was found between biochemical or cytologic parameters and gammagraphic results. Weight and gland volume were significantly greater for adenomas than for hyperplasia (P < 0.0014 and P < 0.0004, respectively), and statistically significant differences in both of them were observed between the glands with positive and negative sestamibi.
authors.affiliation: Department of General Surgery, Pathological Anatomy, and Nuclear Medicine, "Virgen de la Arrixaca" University Hospital, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Piñero
authors.forename: J M
authors.initials: JM
authors.lastname: Rodriguez
authors.forename: S
authors.initials: S
authors.lastname: Ortiz
authors.forename: T
authors.initials: T
authors.lastname: Soria
authors.forename: J
authors.initials: J
authors.lastname: Bermejo
authors.forename: M A
authors.initials: MA
authors.lastname: Claver
authors.forename: M
authors.initials: M
authors.lastname: Canteras
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000000981:diagnostic imaging / Q000378:metabolism; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi / Q000493:pharmacokinetics
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi