The Mukaiyama-Michael reaction of N-acyl-2,3-dihydro-4-pyridones: regio- and stereoselective synthesis of cis-2,6-disubstituted 1,2,5,6-tetrahydropyridines.
[formula: see text] A convenient regio- and stereoselective preparation of 1,2,5,6-tetrahydropyridines of the type 1 has been developed, starting from readily available N-acyl-2,3-dihydro-4-pyridones 2.
Kuethe
J T
JT
Department of Chemistry, North Carolina State University, Raleigh 27695-8204, USA.
Comins
D L
DL
D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry*; D013237:Stereoisomerism
D011725:Pyridines; D011728:Pyridones