title: Anticarcinogenicity potential of spinasterol isolated from squash flowers.
abstract: Spinasterol, an antimutagen, was isolated from squash flowers by solvent partitioning and repeated vacuum liquid chromatography. Spinasterol was then tested for its anticarcinogenic potential by using the mouse skin tumor assay. There was a 90% skin tumor incidence for the positive control group (DMBA + croton oil + acetone). At a concentration of 15.0 microg/0.2 ml acetone, spinasterol decreased the incidence of skin tumors by 55.6% and decreased the number of tumors by 65.0% when applied immediately after croton oil. Hence, spinasterol showed antitumorigenic potential. It is not a co-carcinogen nor a co-tumor promoter as there was no increase in the incidence of skin tumors after spinasterol application. Teratogenesis Carcinog. Mutagen. 20:99-105, 2000.
authors.affiliation: Institute of Chemistry, University of the Philippines, Diliman, Quezon City, Philippines.
authors.forename: I M
authors.initials: IM
authors.lastname: Villaseñor
authors.forename: A P
authors.initials: AP
authors.lastname: Domingo
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity; D002725:Chloroform; D002853:Chromatography, Liquid; D003043:Cocarcinogenesis; D003436:Croton Oil / Q000633:toxicity; D019662:Cucurbitaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D000432:Methanol; D051379:Mice; D015394:Molecular Structure; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D012997:Solvents; D013265:Stigmasterol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D013997:Time Factors
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D012997:Solvents; C031312:spinasterol; D015127:9,10-Dimethyl-1,2-benzanthracene; D002725:Chloroform; D003436:Croton Oil; D013265:Stigmasterol; D000432:Methanol