Catalytic, asymmetric synthesis of the C(1)(')-C(10)(') segment of pamamycin 621A.
[reaction--see text] This paper describes a catalytic, asymmetric approach to the C(1)(')-C(10)(') segment of pamamycin 621A. We synthesize this segment in a convergent manner, with each of the coupling partners ultimately deriving from enantiomerically enriched methylketene dimer.
Calter
M A
MA
Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061-0212, USA. calter@chem.rochester.edu
Bi
F C
FC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D018942:Macrolides; D009930:Organic Chemicals; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000995:Antitubercular Agents; D018942:Macrolides; D009930:Organic Chemicals; C024500:pamamycin