Skin development: delta laid bare.
Notch signalling is best known for its role in lateral inhibition, where it acts to prevent differentiation of cells neighbouring one that has 'won out' in a competition to differentiate. Recent results suggest that Notch signalling can work in the opposite way, and promote differentiation of the receiving cells.
Pourquié
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Laboratoire de Génétique et de Physiologie du Développement (LGPD), Marseille Cedex 09, 13288, France. pourquie@ibdm.univ-mrs.fr
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015603:Keratinocytes / Q000166:cytology / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000502:physiology; D051880:Receptors, Notch; D015398:Signal Transduction; D012867:Skin / Q000166:cytology*; D012879:Skin Physiological Phenomena
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; C064045:delta protein