[Effect of oral contraceptive administration on the frequency of estrogen receptor and cervical intraepithelial neoplasia].
A study of 56 sexual active women with cervical intraepithelial neoplasia (CIN) was conducted in Mexico City, to determine wether the risk for this condition is altered by using oral contraceptives. Responses of a standardized questionnaire compared 29 patients under oral contraceptive (OC) treatment and 27 control subjects selected from the same screening program, though which the cases were detected. Estrogen receptor (ER) levels were determined in each hyperplastic tissue. The ER frequency was approximately the same in women under oral contraceptive (OC) treatment and in women without it. (P > 0.05). Among other risk factors, first intercourse at an early age, first pregnancy age, number of pregnancies and multiple sexual partners were consistently no significant (p > 0.05) when both groups were compared. In this study, we have found no evidence of an etiologic relationship between neither oral contraceptive usage or non usage and CIN.
Salazar
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EL
Unidad de Investigación Médica en Medicina Reproductiva, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, México, D.F.
Contreras
H
H
González
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JL
D000293:Adolescent; D000328:Adult; D003276:Contraceptives, Oral; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis*; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000737:chemistry* / Q000453:epidemiology* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000737:chemistry* / Q000453:epidemiology* / Q000473:pathology
D003276:Contraceptives, Oral; D011960:Receptors, Estrogen