Hyalinizing Spitz nevus.
A seventeen-year-old Korean girl had a reddish-brown papular lesion on the nose. Histopathologically, it proved to be a "hyalinizing Spitz nevus" with the characteristic features of a discohesive growth pattern of nevus cells and hyalinized stroma. Immunohistochemical stains showed positive reactivity of nevus cells with S-100 protein and Vimentin and negative stainings with HMB45, CD68, CEA and low molecular weight cytokeratin. Hyalinizing Spitz nevus may represent a variant in the spectrum of Spitz nevus.
Lee
M W
MW
Department of Dermatology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
Choi
J H
JH
Sung
K J
KJ
Moon
K C
KC
Koh
J K
JK
D000293:Adolescent; D005148:Facial Dermatoses / Q000473:pathology*; D005260:Female; D006801:Humans; D006818:Hyalin; D007150:Immunohistochemistry; D018332:Nevus, Epithelioid and Spindle Cell / Q000473:pathology*; D009666:Nose; D012878:Skin Neoplasms / Q000473:pathology*