title: Animal model of Alzheimer-like vascular pathology and inflammatory reaction.
abstract: This in vivo animal model of vascular inflammatory reaction facilitates morphologic and hemodynamic analyses of leukocyte-endothelial interaction and can be monitored by video microscopy and electron microscopy. The model has served as a rapid means to explore the deleterious vascular actions and inflammatory response to the cytokines tumor necrosis factor, interleukin-1 and amyloid-beta, as well as the protective effects of superoxide dismutase, estrogen, and cytokine antagonists.
authors.affiliation: Department of Anatomy, College of Medicine, University of South Florida, Tampa 33612, USA. jrhodin@com1.med.usf.edu
authors.forename: J
authors.initials: J
authors.lastname: Rhodin
authors.forename: T
authors.initials: T
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Bryant
authors.forename: E T
authors.initials: ET
authors.lastname: Sutton
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology* / Q000517:prevention & control; D016229:Amyloid beta-Peptides / Q000633:toxicity; D000818:Animals; D001160:Arterioles / Q000473:pathology; D002352:Carrier Proteins / Q000494:pharmacology; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D004967:Estrogens / Q000494:pharmacology; D006439:Hemodynamics; D007249:Inflammation; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000633:toxicity; D007962:Leukocytes / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D018715:Microscopy, Video; D010446:Peptide Fragments / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D012795:Sialoglycoproteins / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha / Q000633:toxicity
chemical_list: D016229:Amyloid beta-Peptides; D002352:Carrier Proteins; D004967:Estrogens; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D010446:Peptide Fragments; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D012795:Sialoglycoproteins; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha; C078592:amyloid beta-protein (1-40); C069521:recombinant human tumor necrosis factor-binding protein-1; D013482:Superoxide Dismutase