Treatment of low-grade pediatric gliomas.
The prognosis of pediatric low-grade gliomas is relatively favorable, but residual or unresectable tumors remain a challenge. Conventional radiation therapy is effective but may be associated with unacceptable sequelae in young children. Chemotherapy can delay the need for radiation therapy in young children; however, its role in older children has yet to be established. New forms of radiation are being introduced that may be less toxic.
Schmandt
S M
SM
Department of Neurology, Children's National Medical Center, Washington, DC 20010, USA.
Packer
R J
RJ
D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005910:Glioma / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007223:Infant; D011379:Prognosis