Visual-vestibular interaction in progressive supranuclear palsy.
We measured the stability of gaze during horizontal head rotations at 1-3 Hz in four patients with progressive supranuclear palsy (PSP), while they viewed a stationary target. Median gain of compensatory eye movements was 0.94, similar to control subjects. During rotation in darkness, median gain of vestibulo-ocular reflex (VOR) was 0.88, similar to controls. Conversely, the median gain of smooth-pursuit eye movements at 1.0 Hz was 0.23, lower than controls. A simple superposition model of smooth pursuit and the VOR could not account for the observed gaze stability during fixation. Our results are further evidence that a visually mediated mechanism, independent of smooth pursuit, optimizes eye movements to compensate for head rotations.
Das
V E
VE
Department of Neurology, Department of Veterans Affairs Medical Center and University Hospitals, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106-5040, USA.
Leigh
R J
RJ
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011698:Pursuit, Smooth / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology*; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology*