Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm.
We describe the identification and expression pattern of Xenopus frizzled 4 (Xfz4) gene during early development. Xfz4 protein presents characteristic features of a frizzled family member. The mature protein sequence of Xfz4 is 93% identical to murine Mfz4. Xfz4 is a maternal mRNA, its expression level remains constant during early development. The mRNA is first localized during gastrulation to the dorsal presumptive neuroectoderm. At the end of gastrulation, Xfz4 mRNA is detected in the dorso-anterior neuroectoderm. During neurulation, Xfz4 mRNA is expressed as a band on both side of the forebrain, and in the trunk lateral plate mesoderm. As development proceeds, expression of Xfz4 mRNA in the trunk lateral plate mesoderm decreases but persists in the forebrain. It is also expressed in the posterior unsegmented somitic mesoderm from late tail-bud stage onward.
Shi
D L
DL
Groupe de Biologie Expérimentale, Laboratoire de Biologie Moléculaire et Cellulaire du Dévelopment, CNRS UMR 7622, Université Pierre et Marie Curie, Paris, France. dshi@ccr.jussieu.fr
Boucaut
J C
JC
D000595:Amino Acid Sequence; D000818:Animals; D004475:Ectoderm / Q000502:physiology*; D004625:Embryo, Nonmammalian; D005260:Female; D051157:Frizzled Receptors; D018507:Gene Expression Regulation, Developmental; D007814:Larva; D008648:Mesoderm / Q000502:physiology*; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D017386:Sequence Homology, Amino Acid; D014981:Xenopus / Q000196:embryology / Q000235:genetics*; D029867:Xenopus Proteins
D051157:Frizzled Receptors; C498580:Fzd4 protein, Xenopus; D011506:Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D029867:Xenopus Proteins