title: The potential of active metabolites of antihistamines in the management of allergic disease.
authors.affiliation: Department of Respiratory Medicine, Royal Liverpool University Hospital, UK.
authors.forename: M M
authors.initials: MM
authors.lastname: Abdelaziz
authors.forename: O A
authors.initials: OA
authors.lastname: Khair
authors.forename: J L
authors.initials: JL
authors.lastname: Devalia
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002090:Butyrophenones / Q000494:pharmacology; D002478:Cells, Cultured; D017332:Cetirizine / Q000627:therapeutic use; D053818:Chymases; D004804:Eosinophils / Q000187:drug effects / Q000276:immunology; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000032:analysis; D016298:Hematopoietic Cell Growth Factors / Q000032:analysis; D006632:Histamine / Q000032:analysis; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D007377:Interleukin-3; D016209:Interleukin-8 / Q000032:analysis; D017336:Loratadine / Q000031:analogs & derivatives; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology; D010880:Piperidines / Q000494:pharmacology; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000494:pharmacology; D015230:Prostaglandin D2 / Q000032:analysis; D011725:Pyridines / Q000494:pharmacology; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D012697:Serine Endopeptidases / Q000032:analysis; D016593:Terfenadine / Q000031:analogs & derivatives / Q000627:therapeutic use; D013997:Time Factors; D053802:Tryptases
chemical_list: D000893:Anti-Inflammatory Agents; D002090:Butyrophenones; D016298:Hematopoietic Cell Growth Factors; D006634:Histamine H1 Antagonists; D007377:Interleukin-3; D016209:Interleukin-8; D010880:Piperidines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D011725:Pyridines; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; C404145:myelopoietin; D018799:Intercellular Adhesion Molecule-1; D016179:Granulocyte Colony-Stimulating Factor; C058251:carebastine; D017336:Loratadine; D016593:Terfenadine; D006632:Histamine; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; C093230:fexofenadine; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; C121345:desloratadine; D015230:Prostaglandin D2; D017332:Cetirizine