Induction of CD44 expression in stab wounds of the brain: long term persistence of CD44 expression.
We studied the expression of the hyaluronan receptor protein CD44 in the mouse brain in response to stab injuries. CD44 expression was strongly activated in the area surrounding the injury within 2 days and then persisted for over 2 months. The expression extended in a direct line the depth of the actual wound inflicted. It appears that CD44 may be involved in the wound healing processes following injury to the brain.
Stylli
S S
SS
Department of Neurosurgery, The Royal Melbourne Hospital, University of Melbourne, Parkville, Australia.
Kaye
A H
AH
Novak
U
U
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism; D005786:Gene Expression Regulation; D005910:Glioma / Q000378:metabolism; D018960:Hyaluronan Receptors / Q000235:genetics / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods; D051379:Mice; D013194:Staining and Labeling / Q000379:methods; D013997:Time Factors; D014951:Wounds, Stab / Q000378:metabolism*
D018960:Hyaluronan Receptors