title: Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity.
abstract: Methotrexate, an antirheumatic drug that may increase serum homocysteine, significantly increases mortality in patients with rheumatoid arthritis and cardiovascular comorbidity.
authors.forename: R B
authors.initials: RB
authors.lastname: Landewé
authors.forename: B E
authors.initials: BE
authors.lastname: van den Borne
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld
authors.forename: B A
authors.initials: BA
authors.lastname: Dijkmans
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000453:epidemiology* / Q000401:mortality; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000453:epidemiology* / Q000401:mortality; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate