Positioning the isthmic organizer where Otx2 and Gbx2meet.
Regional diversity along the anterior-posterior axis of the central nervous system is established during gastrulation and is subsequently refined by local organizing centres that are located at genetically defined positions. The isthmic organizer possesses midbrain- and cerebellum-inducing properties, and its positioning at the midbrain-hindbrain boundary is a crucial event that controls midbrain and cerebellum development. Recent work has shown that two transcription factors, Otx2 and Gbx2, are instrumental in positioning the isthmic organizer at the midbrain-hindbrain boundary.
Simeone
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International Institute of Genetics and Biophysics, CNR, Via G. Marconi 12, 80125 Naples, Italy. simeone@iigbna.iigb.an.cnr.it
D000818:Animals; D019521:Body Patterning; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D051857:Otx Transcription Factors; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051857:Otx Transcription Factors; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C513181:gbx2 protein, zebrafish; D051524:Fibroblast Growth Factor 8; D005346:Fibroblast Growth Factors