The combination of elastase and sulfur dioxide exposure causes COPD-like lesions in the rat.
Kodavanti
U P
UP
Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environment Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Jackson
M C
MC
Ledbetter
A D
AD
Starcher
B C
BC
Evansky
P A
PA
Harewood
A
A
Winsett
D W
DW
Costa
D L
DL
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002452:Cell Count; D004195:Disease Models, Animal; D004357:Drug Synergism; D007322:Instillation, Drug; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008173:Lung Diseases, Obstructive / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D010196:Pancreatic Elastase / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011914:Rats, Inbred BN; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*; D014132:Trachea
D000393:Air Pollutants; D013458:Sulfur Dioxide; D007770:L-Lactate Dehydrogenase; D010196:Pancreatic Elastase