title: Heart rate dynamics at the onset of ventricular tachyarrhythmias as retrieved from implantable cardioverter-defibrillators in patients with coronary artery disease.
abstract: BACKGROUND
  The recent availability of implantable cardioverter-defibrillators (ICDs) that record 1024 R-R intervals preceding a ventricular tachyarrhythmia (VTA) provides a unique opportunity to analyze heart rate variability (HRV) before the onset of VTA.
  
  
  RESULTS
  Fifty-eight post-myocardial infarction patients with an implanted ICD for recurrent VTA provided 2 sets of 98 heart rate recordings in sinus rhythm: (1) before a VTA and (2) during control conditions. Three subgroups were considered according to the antiarrhythmic (AA) drug regimen. A state of sympathoexcitation was suggested by the significant reduction in HRV before VTA onset compared with control conditions. beta-Blockers and dl-sotalol enhanced HRV in control recordings; nevertheless, HRV declined before VTA independent of AA drugs. A gradual increase in heart rate and decrease in sinus arrhythmia at VTA onset were specific findings of patients who received dl-sotalol.
  
  
  CONCLUSIONS
  The peculiar heart rate dynamics observed before VTA onset are suggestive of a state of sympathoexcitation that is independent of AA drugs.
authors.affiliation: Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. etienne.pruvot@chuv.hospvd.ch
authors.forename: E
authors.initials: E
authors.lastname: Pruvot
authors.forename: G
authors.initials: G
authors.lastname: Thonet
authors.forename: J M
authors.initials: JM
authors.lastname: Vesin
authors.forename: G
authors.initials: G
authors.lastname: van-Melle
authors.forename: K
authors.initials: K
authors.lastname: Seidl
authors.forename: H
authors.initials: H
authors.lastname: Schmidinger
authors.forename: J
authors.initials: J
authors.lastname: Brachmann
authors.forename: W
authors.initials: W
authors.lastname: Jung
authors.forename: E
authors.initials: E
authors.lastname: Hoffmann
authors.forename: R
authors.initials: R
authors.lastname: Tavernier
authors.forename: M
authors.initials: M
authors.lastname: Block
authors.forename: A
authors.initials: A
authors.lastname: Podczeck
authors.forename: M
authors.initials: M
authors.lastname: Fromer
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D003327:Coronary Disease / Q000150:complications*; D017147:Defibrillators, Implantable; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D013015:Sotalol / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D013015:Sotalol