title: Antimycobacterial activity of ionic fullerene derivatives.
abstract: Positively charged fullerene derivatives, moderately soluble in water:DMSO 9:1, have been tested using three strains of Mycobacterium spp. Some compounds inhibit the growth of Mycobacterium tuberculosis, a human clinical isolate, particularly virulent and resistant, at doses as low as 5 microg/mL.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Trieste, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bosi
authors.forename: T
authors.initials: T
authors.lastname: Da Ros
authors.forename: S
authors.initials: S
authors.lastname: Castellano
authors.forename: E
authors.initials: E
authors.lastname: Banfi
authors.forename: M
authors.initials: M
authors.lastname: Prato
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002244:Carbon / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects*; D009162:Mycobacterium avium / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology*; D012995:Solubility; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D011759:Pyrrolidines; D002244:Carbon