Water extract of defatted rice bran suppresses visceral fat accumulation in rats.
Rice bran has been reported to inhibit pancreatic lipase activity in vitro. This action shows that administration of rice bran may result in a decrease in plasma triglyceride levels and suppress accumulation of fat in vivo. We administered water extract of defatted rice bran (WED-rice bran) to rats to determine its effects. Single administration of WED-rice bran at a dose of 1 g/kg body weight caused a decrease in plasma triglyceride levels in fat emulsion induced hypertriglyceridemic rats. Four week administration of WED-rice bran suppressed accumulation of visceral fat and body weight gain without influencing food consumption, liver function, and renal function. These results indicate that a reduction of plasma triglycerides and suppression of visceral fat accumulation may be induced by pancreatic lipase inhibition caused by administration of WED-rice bran.
Tsutsumi
K
K
Nutrition Research Institute and Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc., Muya-cho, Naruto, Tokushima 772-8601, Japan.
Kawauchi
Y
Y
Kondo
Y
Y
Inoue
Y
Y
Koshitani
O
O
Kohri
H
H
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D008049:Lipase / Q000037:antagonists & inhibitors; D008055:Lipids / Q000097:blood; D008297:Male; D009929:Organ Size; D012275:Oryza / Q000737:chemistry*; D010179:Pancreas / Q000201:enzymology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000737:chemistry*
D008055:Lipids; D010936:Plant Extracts; D014867:Water; D008049:Lipase