title: The effects of dynamic optical properties during interstitial laser photocoagulation.
abstract: A nonlinear mathematical model was developed and experimentally validated to investigate the effects of changes in optical properties during interstitial laser photocoagulation (ILP). The effects of dynamic optical properties were calculated using the Arrhenius damage model, resulting in a nonlinear optothermal response. This response was experimentally validated by measuring the temperature rise in albumen and polyacrylamide phantoms. A theoretical study of ILP in liver was conducted constraining the peak temperatures below the vaporization threshold. The temperature predictions varied considerably between the static and dynamic scenarios, and were confirmed experimentally in phantoms. This suggests that the Arrhenius model can be used to predict dynamic changes in optical and thermal fields. An increase in temperature rise due to a decrease in light penetration within the coagulated region during ILP of the liver was also demonstrated. The kinetics of ILP are complex and nonlinear due to coagulation, which changes the tissue properties during treatment. These complex effects can be adequately modelled using an Arrhenius damage formulation.
authors.affiliation: The Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Canada.
authors.forename: M N
authors.initials: MN
authors.lastname: Iizuka
authors.forename: I A
authors.initials: IA
authors.lastname: Vitkin
authors.forename: M C
authors.initials: MC
authors.lastname: Kolios
authors.forename: M D
authors.initials: MD
authors.lastname: Sherar
mesh_terms: D000180:Acrylic Resins; D000418:Albumins; D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D017075:Laser Coagulation / Q000379:methods* / Q000706:statistics & numerical data; D008099:Liver / Q000601:surgery; D009369:Neoplasms / Q000601:surgery; D017711:Nonlinear Dynamics; D055095:Optics and Photonics; D019047:Phantoms, Imaging; D013816:Thermodynamics; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000418:Albumins; D000099166:Polyacrylamides