title: Detection of the interleukin 18 family in rat brain by RT-PCR.
abstract: Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR.
authors.affiliation: School of Biological Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK.
authors.forename: R D
authors.initials: RD
authors.lastname: Wheeler
authors.forename: A C
authors.initials: AC
authors.lastname: Culhane
authors.forename: M D
authors.initials: MD
authors.lastname: Hall
authors.forename: S
authors.initials: S
authors.lastname: Pickering-Brown
authors.forename: N J
authors.initials: NJ
authors.lastname: Rothwell
authors.forename: G N
authors.initials: GN
authors.lastname: Luheshi
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18 / Q000235:genetics*; D053728:Interleukin-18 Receptor beta Subunit; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018123:Receptors, Interleukin / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D053724:Receptors, Interleukin-18; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D006023:Glycoproteins; C486426:Il18rap protein, rat; D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18; D053728:Interleukin-18 Receptor beta Subunit; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D017472:Receptors, Interleukin-1; D053724:Receptors, Interleukin-18; C118370:interleukin-18 binding protein