title: Blunt trauma resuscitation: the old can respond.
abstract: OBJECTIVE
  Old and young trauma patients are capable of hyperdynamic response during standardized shock resuscitation.
  
  
  METHODS
  The responses of old and young trauma patients resuscitated using a standardized protocol are compared in an inception cohort study. A standardized resuscitation protocol was used to attain and maintain an oxygen delivery index of 600 mL/min x m2 or greater (DO2I > or = 600) for the first 24 hours in the intensive care unit. Interventions, responses, and outcomes for old (> or = 65 years) and young (<65 years) patients are described. Data were analyzed using analysis of variance, the chi2 test, and the t test; P<.05 was considered significant.
  
  
  METHODS
  A 20-bed shock trauma intensive care unit in a regional level I trauma center.
  
  
  METHODS
  Patients at high risk of postinjury multiple organ failure, ie, major organ or vascular injury and/or skeletal fractures, initial base deficit of 6 mEq/L or greater, need for 6 units or more of packed red blood cells in the first 12 hours, or age of 65 years or older with any 2 previous criteria.
  
  
  METHODS
  Pulmonary artery catheter, crystalloid fluid infusion, packed red blood cell transfusion, and moderate inotrope support, as needed in that sequence, to attain DO2I > or = 600.
  
  
  METHODS
  Intensive care unit length of stay and survival.
  
  
  RESULTS
  During 19 months ending June 1999, 12 old patients (58% male; age, 76 +/- 2 years [mean +/- SEM] [P<.0011; Injury Severity Score, 20 +/- 2 [P=.02]) and 54 young patients (61% male; age, 37 +/- 2 years; Injury Severity Score, 32 +/- 2) were resuscitated. Initially, for old patients (cardiac index, 2.0 +/- 0.2 L/min x m2) and for young patients (cardiac index, 3.0 +/- 0.2 L/min x m2; P=.01), 24-hour volumes were as follows: 16 +/- 3 L of crystalloid and 12 +/- 3 units of packed red blood cells for the old patients and 21 +/- 2 L of crystalloid and 19 +/- 2 units of packed red blood cells for the young patients. For old patients, 9 (75%) attained DO2I > or = 600, and 11 (92%) survived 7 or more days and 5 (42%) 30 or more days. For young patients, 45 (83%) attained the DO2I goal, and 48 (89%) survived 30 or more days. Intensive care unit length of stay was 25 +/- 9 days for the old patients and 23 +/- 2 days for the young patients.
  
  
  CONCLUSIONS
  Elderly patients have initially depressed cardiac index but generate hyperdynamic response. Although ultimate outcome is poorer than in the younger cohort, resuscitation is not futile.
authors.affiliation: Department of Anesthesiology, University of Texas-Houston Medical School, 77030, USA. bmckinle@anes1.med.uth.tmc.edu
authors.forename: B A
authors.initials: BA
authors.lastname: McKinley
authors.forename: R G
authors.initials: RG
authors.lastname: Marvin
authors.forename: C S
authors.initials: CS
authors.lastname: Cocanour
authors.forename: A
authors.initials: A
authors.lastname: Marquez
authors.forename: D N
authors.initials: DN
authors.lastname: Ware
authors.forename: F A
authors.initials: FA
authors.lastname: Moore
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D017707:Erythrocyte Transfusion; D005260:Female; D005440:Fluid Therapy; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D011651:Pulmonary Artery; D012151:Resuscitation / Q000379:methods / Q000401:mortality; D014949:Wounds, Nonpenetrating / Q000401:mortality / Q000628:therapy*