Maternal levels of vitamin E in normal and preeclamptic pregnancy.
Vitamin E, a potent antioxidant, may play a role in preventing preeclampsia. Maternal blood samples were collected between 28 and 40 weeks' gestation from women with mild preeclampsia (n=17), women with severe preeclampsia (n=16) and the control group (n=15). This control group was consisted of 15 pregnant women without hypertension episode during their pregnancy. Vitamin E levels were significantly higher in normotensive pregnant women (1.00+/-0.20 mg/dL) than in those with mild (0.56+/-0.15 mg/dL) or severe (0.37+/-0.75 mg/dL) preeclampsia (P<0.001). In preeclamptic women, when systolic blood pressure increases, maternal levels of vitamin E significantly decrease (P<0.05), also when diastolic blood pressure increases, maternal levels of vitamin E significantly decrease (P<0.05). Measurement of vitamin E concentration in plasma may be useful as a prognostic marker of the likely development of preeclampsia.
Akyol
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Dr Zekai Tahir Burak Women's Hospital, Ankara, Turkey. perinatologyak@superonline.com
Mungan
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Görkemli
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Nuhoglu
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D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010298:Parity; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012016:Reference Values; D013050:Spectrometry, Fluorescence; D014810:Vitamin E / Q000097:blood*
D014810:Vitamin E