title: Lipoprotein(a) levels in formerly small-for-gestational-age children.
abstract: Lipoprotein(a) (Lp(a)) is an independent and inherited risk factor for coronary artery disease. Concentrations of Lp(a) have been widely described in adolescents, but little is known about its concentration in children born small for gestational age (SGA). To assess the influence of intrauterine growth on Lp(a) levels we examined 50 children born SGA and 21 children born adequate for gestational age (AGA). Lp(a) blood levels (mean +/- SD) of the SGA children differed significantly (p < 0.05) from AGA children (22.3 +/- 22.1 vs. 10.9 +/- 7.6 mg/dl). 14 out of 50 adolescents of the SGA group but 1 out of 21 of the AGA group had elevated Lp(a) (>30 mg/dl) concentrations (p < 0.05). These children also had higher triglyceride (1.0 +/- 0.6 mmol/l vs. 0.74 +/- 0.38 mmol/l) levels (p < 0.05) compared to children with Lp(a) levels <30 mg/dl. Adolescents with Lp(a) levels >30 mg/dl showed a significant inverse relation between Lp(a) levels and gestational age (r = -0.68, p < 0. 005). We hypothesize that impairment of fetal growth might influence serum Lp(a) levels in later life.
authors.affiliation: Children's Hospital, University of Leipzig, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Pulzer
authors.forename: U
authors.initials: U
authors.lastname: Haase
authors.forename: J
authors.initials: J
authors.lastname: Kratzsch
authors.forename: V
authors.initials: V
authors.lastname: Richter
authors.forename: F
authors.initials: F
authors.lastname: Rassoul
authors.forename: W
authors.initials: W
authors.lastname: Kiess
authors.forename: E
authors.initials: E
authors.lastname: Keller
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000209:etiology; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D017270:Lipoprotein(a); D014280:Triglycerides