title: Prenatal and postnatal exposure to ethanol induces changes in the shape of the dendritic spines from hippocampal CA1 pyramidal neurons of the rat.
abstract: 20%-ethanol was provided to adult female rats since a pregestational stage until weaning of the pups, and percentage proportion of thin, mushroom-shaped, stubby, or wide spines from the apical dendrite of hippocampal CA1 pyramidal cells, was counted at 15, 21, 40, and 90 days of age. By-kind-of-spine analysis revealed higher fluctuation of experimental spines, and less percentage of thin spines was observed in the ethanol-intoxicated rats concomitantly with a higher proportion of stubby or wide spines; through development. Because thin spines may propagate the synaptic potentials more efficiently than stubby or wide spines, this findings suggest that the electrical excitability and thereafter the firing pattern of those cells may be altered, due to the toxic effects of chronic ethanol ingestion.
authors.affiliation: Laboratorio de Psicobiología, División de Neurociencias, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, A.P. 7-70, C.P. 58261. Morelia, Michoacán, Mexico.
authors.forename: L
authors.initials: L
authors.lastname: Tarelo-Acuña
authors.forename: E
authors.initials: E
authors.lastname: Olvera-Cortés
authors.forename: I
authors.initials: I
authors.lastname: González-Burgos
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D048429:Cell Size / Q000187:drug effects / Q000502:physiology; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D003712:Dendrites / Q000187:drug effects* / Q000473:pathology* / Q000648:ultrastructure; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017966:Pyramidal Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016622:Silver Staining
chemical_list: D002492:Central Nervous System Depressants; D009498:Neurotoxins; D000431:Ethanol