title: Macromolecular prodrugs. VIII. Synthesis of polymer-gemfibrozil conjugates.
abstract: Gemfibrozil is covalently linked to two similar polymers: poly[alpha,beta-(N-2-hydroxyethyl-DL-aspartamide)] and poly[alpha,beta-(N-3-hydroxypropyl-DL-aspartamide)]. The synthesised polymer drug conjugates differ in average molecular mass, type of covalent bonding, length of spacer, drug-loading and solubility.
authors.affiliation: Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Lovrek
authors.forename: B
authors.initials: B
authors.lastname: Zorc
authors.forename: B
authors.initials: B
authors.lastname: Boneschans
authors.forename: I
authors.initials: I
authors.lastname: Butula
mesh_terms: D015248:Gemfibrozil / Q000138:chemical synthesis*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D010455:Peptides; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives; D011108:Polymers; D011355:Prodrugs / Q000138:chemical synthesis*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000960:Hypolipidemic Agents; D010455:Peptides; D011108:Polymers; D011355:Prodrugs; C008965:alpha,beta-poly((2-hydroxyethyl)-aspartamide); D011102:Polyhydroxyethyl Methacrylate; C023037:poly(2-hydroxyethyl acrylate); D015248:Gemfibrozil