Reactive extraction of penicillin G in hollow-fiber and hollow-fiber fabric modules.
Penicillin G (Pen G) can be rapidly extracted in hollow-fiber liquid-liquid contactors using N-lauryl-N-trialkylmethylamine (Amberlite LA-2) as the extractant. n-Butylacetate is much better than decanol as a diluent for such an extraction, although decanol can give a partition coefficient four times larger. The overall mass transfer coefficient found is a function of aqueous flow on the lumen side of the fiber, and is less dependent on shell-side flow. In backextraction, the overall mass transfer coefficient determined is only one tenth that of the forward extraction, primarily because the hydrophobic hollow fibers used have a high mass transfer resistance under these conditions. The mass transfer experiments show that hollow-fiber extraction of Pen G is competitive with centrifugal extraction. The prospects for extraction of other fermentation products with hollow fibers can be estimated based on the present study.
Yang
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Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, USA. chyang@cems.umn.edu
Cussler
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D000588:Amines; D010400:Penicillin G / Q000302:isolation & purification*
D000588:Amines; C016214:Amberlite LA-2; D010400:Penicillin G