title: Kinetic resolution and isomerization of 2,5-disubstituted pyrrolines.
abstract: The efficient kinetic resolution of 2,5-disubstituted pyrrolines was accomplished by employing hydrosilylation with a chiral catalyst, (EBTHI)TiF2 (EBTHI = ethylenebis(tetrahydroindenyl)). An interesting isomerization reaction of the cyclic imines catalyzed by the same chiral catalyst was also discovered.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
authors.forename: J
authors.initials: J
authors.lastname: Yun
authors.forename: S L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002621:Chemistry / Q000379:methods*; D007097:Imines / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D007097:Imines; D011758:Pyrroles; C013231:pyrroline