Identification of six CAG repeat domains into the human chromosomic region 12q24.1.
Six different domains of CAG repeats from a human chromosome 12-specific cosmid library were identified, cloned, and sequenced. These CAG repeat domains were localized into the human chromosomic region 12q24.1. Five of them constitute repeat candidates for expansions in autosomal dominant neurological disorders with genetic anticipation, and they can also contribute to the chromosome walking in the human genome project.
Aguiar
J
J
Division of Pharmaceutics, Center for Genetic Engineering and Biotechnology, Havana City, Cuba.
D020132:Anticipation, Genetic; D000067528:Ataxins; D001483:Base Sequence; D016386:Chromosome Walking; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D003360:Cosmids / Q000235:genetics; D015342:DNA Probes / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005973:Glutamine / Q000235:genetics; D006639:Histidine / Q000235:genetics; D016045:Human Genome Project; D006801:Humans; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins; D009422:Nervous System Diseases / Q000235:genetics; D010455:Peptides / Q000235:genetics; D011506:Proteins / Q000235:genetics; D019680:Trinucleotide Repeat Expansion / Q000235:genetics; D018911:Trinucleotide Repeats / Q000235:genetics*
D000067528:Ataxins; D003062:Codon; D015342:DNA Probes; D009419:Nerve Tissue Proteins; D010455:Peptides; D011506:Proteins; D005973:Glutamine; C097188:polyglutamine; D006639:Histidine