Structure-based library design: molecular modelling merges with combinatorial chemistry.
Recent advances in both computational and experimental techniques now allow a very fruitful interplay of computational and combinatorial chemistry in the structure-based design of combinatorial libraries.
Böhm
H J
HJ
Pharmaceuticals Division, Hoffmann-La Roche Ltd, Basel, CH 4070, Switzerland. hans-joachim.boehm@roche.com
Stahl
M
M
D020650:Combinatorial Chemistry Techniques; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation
D008024:Ligands