title: Heart transplantation for radiation-associated end-stage heart failure.
abstract: Radiation-induced heart disease is an increasingly recognized late sequela of mediastinal radiation therapy for malignant neoplasms. We report four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy. Short-term and intermediate-term results are excellent with all four patients currently surviving a mean of 48 months after transplantation. Neither a second malignancy nor recurrence of the primary malignancy has been observed to date. The early results of heart transplantation for end-stage, radiation-induced heart disease are encouraging.
authors.affiliation: Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: N
authors.initials: N
authors.lastname: Handa
authors.forename: C G
authors.initials: CG
authors.lastname: McGregor
authors.forename: R C
authors.initials: RC
authors.lastname: Daly
authors.forename: J A
authors.initials: JA
authors.lastname: Dearani
authors.forename: B S
authors.initials: BS
authors.lastname: Edwards
authors.forename: R P
authors.initials: RP
authors.lastname: Frantz
authors.forename: L J
authors.initials: LJ
authors.lastname: Olson
authors.forename: R J
authors.initials: RJ
authors.lastname: Rodeheffer
mesh_terms: D000328:Adult; D002303:Cardiac Output, Low / Q000209:etiology* / Q000601:surgery*; D002648:Child; D016027:Heart Transplantation; D019337:Hematologic Neoplasms / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D014184:Transplantation, Homologous