BMP, Wnt and Hedgehog signals: how far can they go?
Wnt, Hedgehog and bone morphogenetic proteins function as either short-range or long-range signaling molecules depending on the tissue in which they are expressed. In the past year, filapodia-like cytoplasmic extensions, cell-surface proteogylcans and/or extracellular binding proteins have been identified that may enable these molecules to signal at a distance. Furthermore, recent studies suggest that variations in the signaling range of these molecules may be due to tissue-specific differences in intracellular processing or tissue-restricted expression of binding proteins.
Christian
J L
JL
Oregon Health Sciences University, School of Medicine, Department of Cell and Developmental Biology, Portland 97201, USA. christia@ohsu.edu
D000818:Animals; D001692:Biological Transport; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D029721:Drosophila Proteins; D004705:Endocytosis; D053823:Hedgehog Proteins; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015398:Signal Transduction; D015534:Trans-Activators; D051155:Wnt1 Protein
D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D011506:Proteins; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051155:Wnt1 Protein; C074622:wg protein, Drosophila