Comparative dissolution testing of paracetamol commercial tablet dosage forms.
Dissolution can best be described as a tool that can provide valuable information about the availability of a drug product. In this study, nine different paracetamol tablet dosage forms available on the Turkish Drug Market have been investigated and physical controls were realized. Paddle and rotating basket apparatus methods were applied to all the formulations. In order to evaluate the dissolution rates, five different kinetics have been studied and the best fitting kinetics was found to be the Hixson-Crowell kinetics. It was found that all the preparations are in accordance with the Pharmacopeia standards.
Ozkan
Y
Y
Gülhane Military Medical Academy, Department of Pharmaceutical Technology, Etlik-Ankara-Turkey.
Ozalp
Y
Y
Savaşer
A
A
Ozkan
S A
SA
D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D007700:Kinetics; D012995:Solubility; D013607:Tablets
D018712:Analgesics, Non-Narcotic; D013607:Tablets; D000082:Acetaminophen