title: Physical map of the region surrounding the OTOFERLIN locus on chromosome 2p22-p23.
abstract: The autosomal recessive form of nonsyndromic deafness DFNB9 has been mapped to a 2-cM region on chromosome 2p22-p23, and the responsible gene, OTOF, has been recently identified by positional cloning combined with a candidate gene approach. In the course of this gene cloning, we established a contig of yeast artificial chromosomes, bacterial artificial chromosomes, and P1 phage artificial chromosomes delimited by polymorphic markers D2S2170 and D2S170, i.e. , extending over approximately 3500 kb. Sixty expressed sequence tags or genes and 14 sequence-tagged sites, 11 of which are polymorphic, were mapped to this contig and assigned to 21 chromosomal intervals.
authors.affiliation: Unit¿e de G¿en¿etique des D¿eficits Sensoriels, CNRS URA 1968, Institut Pasteur, 25 rue du Dr. Roux, Paris Cedex 15, 75724, France.
authors.forename: S
authors.initials: S
authors.lastname: Yasunaga
authors.forename: C
authors.initials: C
authors.lastname: Petit
mesh_terms: D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D020451:Contig Mapping; D003638:Deafness / Q000235:genetics; D020224:Expressed Sequence Tags; D005192:Family Health; D005819:Genetic Markers; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D020161:Physical Chromosome Mapping; D016324:Sequence Tagged Sites
chemical_list: D005819:Genetic Markers; D008565:Membrane Proteins; C118457:OTOF protein, human