Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?
Osteoclast-like cell (OCL-like) differentiation is increased in long term cultures of bone marrow taken from paralyzed areas of paraplegic patients. Among the neuropeptides recently described in bone, calcitonin gene-related peptide (CGRP) has been shown in animal studies to inhibit bone resorption in vivo and OCL-like differentiation in vitro: its deficiency could thus be a link between the neural lesion and increased OCL-like production in paraplegia and some other neurologic disorders. We therefore investigated in this study the effects of CGRP on human OCL-like formation and found that it indeed has an inhibitory effect mediated at least in part via cAMP.
Akopian
A
A
Laboratory of Experimental Hematology, at CHU Brugmann, Universite Libre de Bruxelles, 4 Place Van Gehuchten, 1020 Brussels, Belgium.
Demulder
A
A
Ouriaghli
F
F
Corazza
F
F
Fondu
P
P
Bergmann
P
P
D001854:Bone Marrow Cells / Q000166:cytology* / Q000502:physiology; D001862:Bone Resorption / Q000473:pathology; D015740:Calcitonin Gene-Related Peptide / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000502:physiology*; D002455:Cell Division; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D000242:Cyclic AMP / Q000378:metabolism; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D010010:Osteoclasts / Q000166:cytology* / Q000502:physiology; D010264:Paraplegia / Q000473:pathology
D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D000242:Cyclic AMP; D015740:Calcitonin Gene-Related Peptide