title: A cytotoxic diterpene from Alomia myriadenia.
abstract: An extract of the aerial parts from Alomia myriadenia Schultz-Bip. ex Baker (Asteraceae) showed significant cytotoxicity against a panel of human cancer cell lines in a screening of extracts from Brazilian Atlantic Forest plant species. Employing a bioassay-linked HPLC-electrospray/MS method, followed by semi-preparative HPLC, the active component was isolated and characterized as a mixture of epimers of the labdane diterpene 12S,16-dihydroxy-ent-labda-7,13-dien-15,16-olide.
authors.affiliation: Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou-FIOCRUZ, Belo Horizonte, MG, Brazil.
authors.forename: C L
authors.initials: CL
authors.lastname: Zani
authors.forename: T M
authors.initials: TM
authors.lastname: Alves
authors.forename: R
authors.initials: R
authors.lastname: Queiróz
authors.forename: E S
authors.initials: ES
authors.lastname: Fontes
authors.forename: Y G
authors.initials: YG
authors.lastname: Shin
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: C412197:12,16-dihydroxy-ent-labda-7,13-dien-15,16-olide; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts