Pharmacokinetics of miocamycin following intravenous administration to cattle.
The plasma pharmacokinetics for a single intravenous dose (10 mg/kg body weight) of miocamycin (a 16-membered macrolide drug) was investigated in Holando Argentino cattle (n = 5). Blood drug concentrations were determined by a microbiological method and data were best-fitted to a two-compartment open model. The pharmacokinetic profile consisted of a short distribution phase (t1/2 alpha = 7.41 +/- 0.53 min), followed by an extended terminal elimination phase (t1/2 beta = 2.49 +/- 0.23 h). The volume of distribution at steady-state was large (2.13 +/- 0.17 l/kg), suggesting extensive tissue distribution, the clearance value was 0.60 +/- 0.03 l/h.
Litterio
N J
NJ
Cátedra de Farmacología, Facultad de Veterinaria, U.C.M., Madrid, Spain.
Rubio
M R
MR
Formentini
E A
EA
Díaz
D C
DC
Picco
E J
EJ
Encinas
T
T
Boggio
J C
JC
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001424:Bacterial Infections / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary; D002417:Cattle / Q000097:blood / Q000378:metabolism*; D002418:Cattle Diseases / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D016018:Least-Squares Analysis; D008297:Male; D015644:Miocamycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D015644:Miocamycin