Enantioselective determination by capillary electrophoresis with cyclodextrins as chiral selectors.
This review surveys the separation of enantiomers by capillary electrophoresis using cyclodextrins as chiral selector. Cyclodextrins or their derivatives have been widely employed for the direct chiral resolution of a wide number of enantiomers, mainly of pharmaceutical interest, selected examples are reported in the tables. For method optimisation, several parameters influencing the enantioresolution, e.g., cyclodextrin type and concentration, buffer pH and composition, presence of organic solvents or complexing additives in the buffer were considered and discussed. Finally, selected applications to real samples such as pharmaceutical formulations, biological and medical samples are also discussed.
Fanali
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Istituto di Cromatografia del C.N.R., Area della Ricerca di Roma, Monterotondo Scalo (Rome), Italy. fanali@nserv.icmat.mlib.cnr.it
D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D013237:Stereoisomerism
D003505:Cyclodextrins