title: Spatial learning affects immature granule cell survival in adult rat dentate gyrus.
abstract: Neurogenesis occurs throughout life in mammalian dentate gyrus. The effect of learning on newborn cell survival was studied in rat. Rats were trained on a hippocampus-dependent spatial learning task by using Morris water maze. Neurogenesis was evaluated by 5-bromo-2'deoxyuridine administered before learning. Several newborn cells expressed the immature neuron marker TOAD-64. The main findings were as follows: (1) the survival of newborn cells was enhanced by learning at early stage of differentiation; (2) the newborn cells saved by learning were mainly located in the rostral part of external blade of granule cell layer and (3) there was a correlation between the actual individual learning and newborn cell survival.
authors.affiliation: Institute of Physiological Sciences, University of Urbino, I-61029, Urbino, Italy. p.ambrogini@uniurb.it
authors.forename: P
authors.initials: P
authors.lastname: Ambrogini
authors.forename: R
authors.initials: R
authors.lastname: Cuppini
authors.forename: C
authors.initials: C
authors.lastname: Cuppini
authors.forename: S
authors.initials: S
authors.lastname: Ciaroni
authors.forename: T
authors.initials: T
authors.lastname: Cecchini
authors.forename: P
authors.initials: P
authors.lastname: Ferri
authors.forename: S
authors.initials: S
authors.lastname: Sartini
authors.forename: P
authors.initials: P
authors.lastname: Del Grande
mesh_terms: D000367:Age Factors; D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D015415:Biomarkers; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002452:Cell Count; D002455:Cell Division / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology*; D018891:Dentate Gyrus / Q000166:cytology* / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000502:physiology*; D013037:Spatial Behavior / Q000502:physiology*
chemical_list: D000963:Antimetabolites; D015415:Biomarkers; D001973:Bromodeoxyuridine