title: Multiple solid-phase microextraction.
abstract: Theoretical aspects of multiple solid-phase microextraction are described and the principle is illustrated with the extraction of lidocaine from aqueous solutions. With multiple extraction under non-equilibrium conditions considerably less time is required in order to obtain an extraction yield that is equal to that of one extraction at equilibrium. On the other side, the extraction yield can be increased if multiple extraction is performed with the same total time as is needed for one extraction at equilibrium time. The effect of multiple extraction is strongly dependent on the value of the partition constant and for practical use the length of the desorption time is important. A good agreement between theoretical and experimental data has been obtained. Chromatograms are presented showing the potential of multiple solid-phase microextraction.
authors.affiliation: Department of Analytical Chemistry and Toxicology, University Centre for Pharmacy, Groningen, The Netherlands.
authors.forename: E H
authors.initials: EH
authors.lastname: Koster
authors.forename: G J
authors.initials: GJ
authors.lastname: de Jong
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*