Polylactide microspheres for the modified release of corticosteroids.
A steroidal drug, prednisolone 21-acetate, has been incorporated into polylactide (PDLLA) microspheres using a single emulsion/evaporation technique. This paper describes the method used and the characterization of the microspheres obtained: morphology, particle size distribution, drug content, yield of production and in vitro drug release behaviour.
Giunchedi
P
P
Dipartimento di Scienze del Farmaco, Università degli Studi di Sassari, Italia.
Gavini
E
E
Conti
B
B
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D005079:Excipients; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D012995:Solubility
D000305:Adrenal Cortex Hormones; D005079:Excipients; D011091:Polyesters; C033616:poly(lactide)