Bone marrow examination for primary diagnosis and follow-up in patients with lymphoproliferative disorders. An overview with emphasize on bone marrow histology.
The aim of his overview is to provide some insight into the manifold applications of bone marrow examination in lymphoproliferative disease. Having a large selection of methods any clinician working in this field should be familiar with the diagnostic relevance of each method for a given diagnostic problem. The choice of the appropriate investigations will warrant a correct diagnosis and helps to lower health expenses. Because of the multiplicity of the methods, often performed at different institutions, a lot of confusion can be caused by conflicting interpretation of isolated results. A diagnosis should never be based on isolated findings such as immunophenotyping or demonstration of a clonal population. Results of various investigations are to be integrated into a final diagnostic concept, which will be the basis for therapeutic decisions.
Hurwitz
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Institut für Pathologie Kantonsspital Basel-Universitäa-Kliniken, Basel, Switzerland.
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000473:pathology*