Protective effect of etomidate on kainic acid-induced neurotoxicity in rat hippocampus.
The goal of this study was to determine whether etomidate has protective effect against kainic acid (KA)-induced neurotoxicity. Administration of etomidate (20 mg/kg i.p.) was performed in sequence, first being just 1 h after KA (10 mg/kg i.p.) injection, then three times at 1-h intervals. Neuronal damages in hippocampus were evaluated by using the acid fuchsin stain to detect cell death and the heat shock protein-70 (HSP-70) induction as an index of cell injury at 24 h after the administration of KA. HSP-70 induction and acid fuchsin positive neurons were increased in CA1 and CA3 regions of hippocampus after KA injection but significantly decreased by etomidate-injection. These results suggest that the etomidate hold potential effect on the protection of neurons against KA-induced neurotoxicity.
Lee
J
J
Department of Anatomy, College of Veterinary Medicine, Chonnam National University, Kwangju, South Korea.
Kim
D
D
Hong
H
H
Han
S
S
Kim
J
J
D000818:Animals; D001557:Benzenesulfonates; D016923:Cell Death; D004396:Coloring Agents; D005045:Etomidate / Q000494:pharmacology*; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007608:Kainic Acid / Q000506:poisoning*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001557:Benzenesulfonates; D004396:Coloring Agents; D018840:HSP70 Heat-Shock Proteins; D018696:Neuroprotective Agents; D009498:Neurotoxins; C086337:acid fuchsin; D007608:Kainic Acid; D005045:Etomidate