title: IP-10 is critical for effector T cell trafficking and host survival in Toxoplasma gondii infection.
abstract: The generation of an adaptive immune response against intracellular pathogens requires the recruitment of effector T cells to sites of infection. Here we show that the chemokine IP-10, a specific chemoattractant for activated T cells, controls this process in mice naturally infected with Toxoplasma gondii. Neutralization of IP-10 in infected mice inhibited the massive influx of T cells into tissues and impaired antigen-specific T cell effector functions. This resulted in >1000-fold increase in tissue parasite burden and a marked increase in mortality compared to control antibody-treated mice. These observations suggest that IP-10 may play a broader role in the localization and function of effector T cells at sites of Th1 inflammation.
authors.affiliation: Department of Medicine, Dartmouth Medical Center, Hanover, New Hampshire 03755, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Khan
authors.forename: J A
authors.initials: JA
authors.lastname: MacLean
authors.forename: F S
authors.initials: FS
authors.lastname: Lee
authors.forename: L
authors.initials: L
authors.lastname: Casciotti
authors.forename: E
authors.initials: E
authors.lastname: DeHaan
authors.forename: J D
authors.initials: JD
authors.lastname: Schwartzman
authors.forename: A D
authors.initials: AD
authors.lastname: Luster
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology; D054357:Chemokine CXCL10; D019743:Chemokines, CXC / Q000276:immunology*; D002630:Chemotactic Factors / Q000276:immunology; D007113:Immunity, Innate; D051379:Mice; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology*; D014124:Toxoplasmosis, Animal / Q000276:immunology*
chemical_list: D054357:Chemokine CXCL10; D019743:Chemokines, CXC; D002630:Chemotactic Factors