title: [The dosage of anti-GAD and anti-IA2 autoantibodies: an aid to the early diagnosis of type 1 diabetes].
abstract: Diabetes mellitus is a frequent metabolic disease characterised by a complex and inconstant phenotypic expression that complicates the classification of patients and sometimes delays their optimal management. In that slowly progressive disease leading to severe and irreversible complications, the use of early and specific genetic, immunological and/or metabolic markers may help in the classification of diabetic patients and in the orientation of therapeutic strategies; furthermore, it is also an essential aid in the early screening of subjects at risk of developing the disease. The assessment of classical immunological markers, such as islet cell antibodies (ICA) or anti-insulin antibodies (IAA) has been recently completed by the screening of new promising markers such as GAD- and IA2-antibodies. The presence of these markers confirms the autoimmune component of the disease and thus supports the diagnosis of type 1 diabetes, even if clinical symptoms are absent or inconsistent. In addition, it represents a strong argument in favour of the initiation of specific immunological therapies to preserve B-cell number and function.
authors.affiliation: Département de Biologie Clinique, Université de Liège.
authors.forename: F H
authors.initials: FH
authors.lastname: Luyckx
authors.forename: S
authors.initials: S
authors.lastname: Delcour
authors.forename: J C
authors.initials: JC
authors.lastname: Philips
authors.forename: A J
authors.initials: AJ
authors.lastname: Scheen
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007328:Insulin / Q000032:analysis / Q000276:immunology*; D008403:Mass Screening; D011237:Predictive Value of Tests
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007328:Insulin; D005968:Glutamate Decarboxylase