[Ocular drug penetration].
The study of ocular drug penetration may take into account many factors connected to the ophthalmic route specificity: anatomical barriers of the eye, solubility, molecular weight and eyedrops concentration. The factors influencing ocular drug penetration are reviewed. The broad outlines of research focuses now on an increase of the bioavailability, a best tolerability and a reduction of systemic effects of drugs.
Dupin
O
O
Laboratoire Chauvin, Le Millénaire, BP 1174, F-34009 Montpellier Cedex 1. odupin@chauvingroup.com
Trinquand
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C
D001682:Biological Availability; D003315:Cornea / Q000378:metabolism; D005123:Eye / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D010599:Pharmacokinetics