title: Epsilon aminocaproic acid in paediatric cardiac surgery to reduce postoperative blood loss.
abstract: We have studied the efficacy of epsilon aminocaproic acid in reducing postoperative blood loss in infants and children with congenital cyanotic cardiac anomalies undergoing corrective operative procedures. This prospective study was carried out on 170 infants and children randomly divided into two equal groups. Group A acted as the control group and received normal saline as placebo while group B patients received epsilon aminocaproic acid (100 mg/kg body wt) intravenously slowly soon after anaesthetic induction followed by 100 mg/kg in the cardiopulmonary bypass pump at the time of starting of cardiopulmonary bypass and 100 mg/kg after weaning from bypass over a period of 3 h. In group A the time for sternal closure after separation from bypass and administration of protamine was 75.18 +/- 5.5 min and in group B 50.7 +/- 5.2, (P < 0.001). Blood loss at 24 h in group A was 42.6 +/- 6.9 ml/kg/24 h and in group B 23.7 +/- 5.8 ml/kg/24 h, (P < 0.001). The need for packed red cells in group A was 21.8 +/- 7.1 ml/kg/24 h and in group B 10.7 +/- 7.8 ml/kg/24 h, (P < 0.001). The need for platelet concentrate in group A was 22.0 +/- 6.7 ml/kg/24 h and group B 6.2 +/- 3.2 ml/kg/24 h, (P < 0.001). Fibrin degradation products (split) in group A was 8.2 +/- 0.8 micrograms/ml, and group B 3.8 +/- 1.3 micrograms/ml, (P < 0.001). Reexploration rate was also considerably reduced in group B, 5 of 85 (6%) compared to group A, 13 of 85 (15%), (P < 0.001). It was found that epsilon aminocaproic acid is effective in reducing postoperative blood loss, packed red cells and plasma product requirements in paediatric patients undergoing corrective surgical procedures for congenital cyanotic heart diseases.
authors.affiliation: Department of Cardiac Anaesthesia, All India Institute of Medical Sciences, New Delhi.
authors.forename: B H
authors.initials: BH
authors.lastname: Rao
authors.forename: N
authors.initials: N
authors.lastname: Saxena
authors.forename: S
authors.initials: S
authors.lastname: Chauhan
authors.forename: A K
authors.initials: AK
authors.lastname: Bisoi
authors.forename: P
authors.initials: P
authors.lastname: Venugopal
mesh_terms: D015119:Aminocaproic Acid / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002648:Child; D001026:Coronary Artery Bypass; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D010919:Placebos
chemical_list: D010919:Placebos; D015119:Aminocaproic Acid