Accuracy of MR imaging for detecting epiphyseal extension of osteosarcoma.
BACKGROUND
Too few patients are receiving epiphyseal-sparing limb salvage procedures for osteosarcoma.


OBJECTIVE
To determine how magnetic resonance (MR) imaging can best predict the epiphyseal extension of osteosarcoma.


METHODS
Forty children underwent complete pretreatment static and dynamic contrast-enhanced MR imaging (DEMRI). Static MR images [T1-weighted and short tau inversion recovery (STIR)] of the epiphyses were read in three ways: (1) for suspicion of any abnormality (tumor or edema), (2) for suspicion of tumor, excluding suspected edema, and (3) validating the second method by using a scale to rate the likelihood of tumor. Presentation imaging was compared to histopathologic findings after chemotherapy and resection. The receiver operating characteristic (ROC) method was used to analyze the scaled ratings of static MR and DEMRI values.


RESULTS
At delayed resection, 20 of 40 children with osteosarcoma had confirmed epiphyseal tumor; however, 32 epiphyses were abnormal on STIR and 28 abnormal on T1. Differentiating suspected tumor from edema increased the accuracy to an Az (area under the ROC curve) of 0.94 for both T1-weighted and STIR static sequences. T1-weighted MR had better specificity and STIR better sensitivity at any given rating. DEMRI was slightly less accurate (Az = 0.90).


CONCLUSIONS
Static MR imaging most accurately detected epiphyseal extension of osteosarcoma when readers distinguished suspected tumor from edematous or normal tissue.
Hoffer
F A
FA
Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
Nikanorov
A Y
AY
Reddick
W E
WE
Bodner
S M
SM
Xiong
X
X
Jones-Wallace
D
D
Gronemeyer
S A
SA
Rao
B N
BN
Kauffman
W M
WM
Laor
T
T
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000601:surgery; D002648:Child; D003937:Diagnosis, Differential; D004838:Epiphyses / Q000473:pathology*; D005260:Female; D005269:Femur / Q000473:pathology; D005360:Fibula / Q000473:pathology; D006801:Humans; D006811:Humerus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D012516:Osteosarcoma / Q000175:diagnosis* / Q000601:surgery; D011446:Prospective Studies; D015203:Reproducibility of Results; D013977:Tibia / Q000473:pathology