title: Efficient synthesis of a porphyrin-N-tripod conjugate with covalently linked proximal ligand: toward new-generation active-site models of cytochrome c oxidase.
abstract: [formula: see text] A new-generation cytochrome c oxidase active-site model compound (4) featuring both a trisimidazolyl moiety and a proximal base has been designed and efficiently synthesized. During this study, a facile method based on the chemistry of a 4-magnesioimidazole derivative to synthesize 4-imidazolyl-containing tripodal ligands (7) has been developed.
authors.affiliation: Department of Chemistry, Stanford University, California 94305-5080, USA. jpc@chem.stanford.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Collman
authors.forename: M
authors.initials: M
authors.lastname: Zhong
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Rapta
authors.forename: E
authors.initials: E
authors.lastname: Rose
mesh_terms: D001665:Binding Sites; D003576:Electron Transport Complex IV / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D011166:Porphyrins / Q000138:chemical synthesis*
chemical_list: D008024:Ligands; D011166:Porphyrins; D003576:Electron Transport Complex IV