SPEEDY: spin-echo enhanced diffusion filtered spectroscopy. A new tool for high resolution MAS NMR
The pulsed field gradient diffusion edited experiment, bipolar LED, has been combined with the Carr-Purcell-Meiboom-Gill (CPMG) spin-echo sequence for the analysis of solid phase resin samples. Spin-echo enhanced diffusion filtered spectroscopy (SPEEDY), when optimized, filters both the compounds that demonstrate fast diffusion rates as well as the compounds that demonstrate fast T(2) relaxation rates. Using this technique, compounds that are not covalently attached to the resin are not observed and contributions from the resin matrix are greatly attenuated. The interpretation of the resulting spectrum is more readily accessible. This technique lessens the importance of completely removing reaction residues or the wash solvents simply for analytical evaluation. The utility of the combined filtering scheme was demonstrated by the implementation into a NOESY sequence.
Chin
JA
Core Technologies/Analytics, Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, New Jersey 07901, USA.
Chen
A
Shapiro
MJ