New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus.
Three new 7,20:14,20-diepoxy-ent-kaurane diterpenoids, xerophilusins A-C (1-3), together with a known one, macrocalin B (4), were isolated from the leaves of Isodon xerophilus. Their structures were elucidated on the basis of their spectral properties and X-ray crystallographic analysis. Compounds 1, 2, and 4 showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.
Hou
A J
AJ
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China.
Li
M L
ML
Jiang
B
B
Lin
Z W
ZW
Ji
S Y
SY
Zhou
Y P
YP
Sun
H D
HD
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008942:Mitoxantrone / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C410910:xerophilusin A; C410911:xerophilusin B; C410912:xerophilusin C; C045862:macrocalin B; D008942:Mitoxantrone