Novel cyclic tripeptides and substituted aromatic amino acids via ruthenium-activated S(N)Ar reactions.
[formula: see text] Chlorophenylalanines eta 6-complexed to ruthenium undergo SNAr reactions with a variety of nucleophiles to form substituted phenylalanines exemplified by 4b. Extension of these reactions to intramolecular ruthenium-activated SNAr cyclizations led to three novel cyclic tripeptide systems (exemplified by 17 and 20).
West
C W
CW
Department of Chemistry, University of Wisconsin-Madison 53706, USA.
Rich
D H
DH
D000596:Amino Acids / Q000138:chemical synthesis*; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D010649:Phenylalanine / Q000737:chemistry; D012428:Ruthenium
D000596:Amino Acids; D010456:Peptides, Cyclic; D010649:Phenylalanine; D012428:Ruthenium