title: Cytotoxic triterpenes from Crataegus pinnatifida.
abstract: Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.
authors.affiliation: College of Pharmacy, Chungnam National University, Taejon, Korea.
authors.forename: B S
authors.initials: BS
authors.lastname: Min
authors.forename: Y H
authors.initials: YH
authors.lastname: Kim
authors.forename: S M
authors.initials: SM
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Jung
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: M K
authors.initials: MK
authors.lastname: Na
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
authors.forename: J P
authors.initials: JP
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: Bae
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000138:chemical synthesis / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000097245:Ursolic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; D000097245:Ursolic Acid; C412949:3-oxo-ursolic acid; C013330:uvaol