title: Gastric anti-ulcer activity of several alpha,beta-unsaturated carbonyl compounds in rats.
abstract: The gastric cytoprotective activity of several molecules containing an alpha,beta-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the beta carbon of the Michael acceptors of the compounds assayed.
authors.affiliation: Departamento de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina. alemaria@unsl.edu.ar
authors.forename: A O
authors.initials: AO
authors.lastname: Maria
authors.forename: S
authors.initials: S
authors.lastname: Donadel
authors.forename: G H
authors.initials: GH
authors.lastname: Wendel
authors.forename: J A
authors.initials: JA
authors.lastname: Guzman
authors.forename: E
authors.initials: E
authors.lastname: Guerreiro
authors.forename: O S
authors.initials: OS
authors.lastname: Giordano
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D003517:Cyclopentanes / Q000737:chemistry / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects; D020011:Protective Agents / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013329:Structure-Activity Relationship
chemical_list: D000897:Anti-Ulcer Agents; D003517:Cyclopentanes; D020011:Protective Agents; C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone; C013905:cyclopentenone