title: Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma.
abstract: The herpes simplex virus (HSV) ICP34.5 null mutant 1716 replicates selectively in actively dividing cells and has been proposed as a potential treatment for cancer, particularly brain tumours. We present a clinical study to evaluate the safety of 1716 in patients with relapsed malignant glioma. Following intratumoural inoculation of doses up to 10(5) p.f.u., there was no induction of encephalitis, no adverse clinical symptoms, and no reactivation of latent HSV. Of nine patients treated, four are currently alive and well 14-24 months after 1716 administration. This study demonstrates the feasibility of using replication-competent HSV in human therapy.
authors.affiliation: Beatson Oncology Centre, Western Infirmary, Glasgow, UK.
authors.forename: R
authors.initials: R
authors.lastname: Rampling
authors.forename: G
authors.initials: G
authors.lastname: Cruickshank
authors.forename: V
authors.initials: V
authors.lastname: Papanastassiou
authors.forename: J
authors.initials: J
authors.lastname: Nicoll
authors.forename: D
authors.initials: D
authors.lastname: Hadley
authors.forename: D
authors.initials: D
authors.lastname: Brennan
authors.forename: R
authors.initials: R
authors.lastname: Petty
authors.forename: A
authors.initials: A
authors.lastname: MacLean
authors.forename: J
authors.initials: J
authors.lastname: Harland
authors.forename: E
authors.initials: E
authors.lastname: McKie
authors.forename: R
authors.initials: R
authors.lastname: Mabbs
authors.forename: M
authors.initials: M
authors.lastname: Brown
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D015316:Genetic Therapy / Q000379:methods*; D005909:Glioblastoma / Q000473:pathology / Q000628:therapy* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy* / Q000821:virology; D016896:Treatment Outcome; D014774:Virulence; D014779:Virus Replication