Influence of combined therapeutic potential of meso 2,3-dimercaptosuccinic acid and calcium disodium edetate on lead-induced testicular alterations in rats.
The therapeutic efficacy of a combination of meso 2,3-dimercaptosuccinic acid (DMSA) and calcium disodium EDTA in protecting testicular disorders in chronic lead intoxication was investigated. The results indicate that two five-days courses of the combined therapy produced a more effective recovery in the lead induced biochemical and histopathological disorders compared to conventional single 5 days therapy. No adverse effect of the chelators, when administered individually or in combination, was noticed in the testes of control (without lead exposure) animals.
Flora
G J
GJ
Industrial Toxicology Research Centre, Lucknow, India.
Arora
U
U
Seth
P K
PK
D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004492:Edetic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D007854:Lead / Q000009:adverse effects*; D008297:Male; D051381:Rats; D004113:Succimer / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013736:Testicular Neoplasms / Q000473:pathology*; D013737:Testis / Q000187:drug effects / Q000473:pathology*
D002614:Chelating Agents; D007854:Lead; D004492:Edetic Acid; C091888:monoisoamyl-2,3-dimercaptosuccinate; D004113:Succimer