title: Ischemic heart disease in black South African stroke patients.
abstract: OBJECTIVE
  Stroke patients in western countries frequently have coronary artery disease (CAD). In black Africans, CAD has been reported as being rare in both stroke patients and the general population. In this study, an attempt has been made to determine the prevalence of CAD in a black South African stroke population.
  
  
  METHODS
  The prevalence of CAD was determined by indicators identified through a series of 5 observational studies in black patients diagnosed with stroke. CAD indicators included (1) bedside diagnosis in 741 patients; (2) resting ECG in 555 consecutively admitted patients; (3) a combination of clinical examination, cardiac ultrasound, radionuclide scintigraphy, and multigated blood pool studies in 102 consecutively admitted patients; (4) thallium scintigraphy in 60 patients; and (5) necropsy in 23 patients.
  
  
  RESULTS
  On bedside questioning, only 0.7% complained of previous angina. There was no history given of myocardial infarction (MI), but documentation of this was found in the clinical notes of 0.7% of the patients. In the resting ECG study, evidence of myocardial ischemia was present in 14.6% and MI in 2.1%. In the combined study, cardiac ischemia was documented on ECG in 12.7% of patients and evidence of previous MI in 5.8%. Cardiac scintigraphic studies revealed changes of myocardial ischemia in 31.7% and MI in 13.3% of the 60 patients studied. Four (17.4%) of 23 patients in the necropsy study had histological evidence of previous MI, and 50% of all patients had evidence of >50% atherosclerotic stenosis in 1, 2, or 3 coronary arteries.
  
  
  CONCLUSIONS
  The prevalence of CAD in black African stroke patients is significantly higher than has been documented in the general nonstroke black population as well as in stroke patients. Black stroke patients may have a risk for CAD similar to that of their white counterparts.
authors.affiliation: Department of Neurology, Royal Melbourne Hospital, Parkville, Victoria, Australia. joubert@hotkey.net.au
authors.forename: J
authors.initials: J
authors.lastname: Joubert
authors.forename: C A
authors.initials: CA
authors.lastname: McLean
authors.forename: C M
authors.initials: CM
authors.lastname: Reid
authors.forename: D
authors.initials: D
authors.lastname: Davel
authors.forename: W
authors.initials: W
authors.lastname: Pilloy
authors.forename: R
authors.initials: R
authors.lastname: Delport
authors.forename: L
authors.initials: L
authors.lastname: Steyn
authors.forename: A R
authors.initials: AR
authors.lastname: Walker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People; D002637:Chest Pain / Q000175:diagnosis; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D004176:Dipyridamole; D004452:Echocardiography; D004562:Electrocardiography; D015340:Epidemiologic Research Design; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012008:Recurrence; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D011795:Surveys and Questionnaires
chemical_list: D004176:Dipyridamole