Peripheral leukocytes activation in aortic aneurysmal disease.
The pathogenesis of aneurysmal disease involves factors acting over time. A sustained chronic inflammatory reaction is observed in association with initiations, maintenance, rapid growth and rupture of aortic aneurysms. This study was designed to identify the possible pathogenic role of the inflammatory cells in the outcome of aneurysmal disease, testing the activation state of peripheral lymphocytes and neutrophils. Circulating activated lymphocytes and repeated peaks of neutrophils activation in sequential follow-up is associated with larger aneurysms, mural thrombosis, tendency to aneurysm extension and rupture.
Tănăseanu
C
C
Neagu
M
M
Popescu
M
M
Manda
G
G
Cojocaru
M
M
D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000209:etiology* / Q000276:immunology; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology* / Q000276:immunology; D001019:Aortic Rupture / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D018375:Neutrophil Activation; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D012307:Risk Factors