[Effect of age and radiation exposure on the frequency of translocations and dicentrics detected by FISH method in human lymphocytes].
The frequencies of translocations and dicentrics detected by "chromosome painting" in lymphocytes were estimated in 115 healthy donors and in 273 people exposed to uncontrolled irradiation at low doses 1-4 years ago. Age responses of both types of exchanges at the age range from 3 to 85 years fit to quadratic model. The frequency of translocations grew faster with age than the frequency of dicentrics. The yields of stable exchanges in exposed people was significantly higher than those in control donors of corresponding ages.
Vorobtsova
I E
IE
Gentral Research Institute of Roentgenology and Radiology, Ministry of Health of Russia, St. Petersburg, Russia. radgen@gate.la.spb.ru
Tucker
J D
JD
Timofeeva
N M
NM
Bogomazova
A N
AN
Semenov
A V
AV
Pleshanov
P G
PG
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics* / Q000528:radiation effects*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000528:radiation effects*; D008875:Middle Aged; D011210:Power Plants; D011832:Radiation Injuries / Q000235:genetics*; D018788:Radioactive Hazard Release; D012426:Russia; D014178:Translocation, Genetic / Q000528:radiation effects*; D014455:Ukraine