[Activity of intracellular antioxidant enzymes in hypertensive patients].
OBJECTIVE
To assess activity of oxidation and function of cell antioxidant system in hypertensive patients.


METHODS
24 hypertensive patients (AP 140-180/95-114 mm Hg) were examined before and 4 weeks after standard therapy for plasmic levels of thiobarbituric acid (TBA) reacting products (TBARP), lipid peroxides (LP), total oxidant activity (TOA), total antioxidant activity (TAA) in red cells, activity of superoxide dismutase and catalase. A control group consisted of 16 healthy volunteers matched for age and sex.


RESULTS
The patients had very high TAA and TBARP while the antioxidant status was subnormal. TOA/TAA was higher than in the controls. Clinically effective therapy with basic antihypertensive drugs lowered the oxidant activity and raised the antioxidant status while TOA/TAA index remained elevated.


CONCLUSIONS
Hypertensive patients are exposed to apparent oxidant stress caused by imbalance between adaptive potential of intracellular enzyme antioxidant defense and activity of free radical processes. It is suggested that in pathogenesis of essential hypertension insufficiency of antioxidant enzymes results in development of chronic oxidant stress.
El'chaninova
S A
SA
Galaktionova
L P
LP
Tolmacheva
N V
NV
Varshavskiĭ
B Ia
BIa
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002374:Catalase / Q000009:adverse effects / Q000097:blood*; D002908:Chronic Disease; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D007424:Intracellular Fluid / Q000201:enzymology*; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors / Q000097:blood*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D000959:Antihypertensive Agents; D000975:Antioxidants; D015415:Biomarkers; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D002374:Catalase; D013482:Superoxide Dismutase