title: A new method for the generation and cyclization of iminyl radicals via the Hudson reaction.
abstract: [formula: see text] A mild new synthetic procedure has been developed for in situ generation and cyclization of iminyl radicals onto pendant alkenes, followed by functionalization of the resulting carbon radical by one of a variety of trapping reagents. The key process in the method involves production of the iminyl radical via treatment of an aldoxime or ketoxime with readily available 2,6-dimethylbenzenesulfinyl chloride at -50 degrees C to room temperature (Hudson reaction).
authors.affiliation: Department of Chemistry, Pennsylvania State University, University Park 16802, USA.
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.forename: D
authors.initials: D
authors.lastname: Stien
authors.forename: S M
authors.initials: SM
authors.lastname: Weinreb
mesh_terms: D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D005609:Free Radicals; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000475:Alkenes; D005609:Free Radicals; D007097:Imines