An animal model based on the Sprague Dawley rat for the evaluation of ototoxicity.
Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.
Martini
A
A
Department of ENT, Audiology, University of Ferrara, Italy. mma@dns.unife.it
Hatzopoulos
S
S
Rubini
R
R
Di Stefano
M
M
Albertin
A
A
Govoni
E
E
D000161:Acoustic Stimulation; D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000818:Animals; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007785:Lactose / Q000009:adverse effects / Q000031:analogs & derivatives*; D008747:Methylcellulose / Q000009:adverse effects / Q000031:analogs & derivatives*; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000187:drug effects / Q000502:physiology; D010078:Oxazines; D051381:Rats; D017207:Rats, Sprague-Dawley
D000276:Adjuvants, Immunologic; D010078:Oxazines; D006820:Hyaluronic Acid; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose