Cytosolic drug delivery using pH- and light-sensitive liposomes.
A growing body of literature describes the development and applications of novel targeting and/or contents release triggering schemes to improve the therapeutic index of drugs encapsulated within liposomes. This review focuses on literature appearing between January 1995-December 1997 that report 1) antibody and receptor-mediated targeting approaches for improving drug localization and 2) acid, enzymatic, thermal or photochemical triggering processes that destabilize membranes and improve drug bioavailability via cytoplasmic delivery of liposomal contents.
Gerasimov
OV
Department of Chemistry, Purdue University, West Lafayette, IN, USA
Boomer
JA
Qualls
MM
Thompson
DH