title: Late intramedullary spinal cord metastasis in a patient with lymphoblastic lymphoma: case report.
abstract: Late intramedullary spinal cord metastasis of lymphoblastic lymphoma (LBL) is unreported in the literature. The central nervous system (CNS) sites of metastasis previously documented include the spinal leptomeninges causing epidural spinal cord compression or brain praenchymal sites within a year of primary diagnosis. This report represents the first case of intramedullary spinal cord LBL as a late recurrence. The method consists of a case study of one patient with retrospective analysis of tumour tissues from biopsies at ages 5, 9 and 26. The results show that late spinal cord recurrence was microneurosurgically subtotally debulked and later treated with radiotherapy with improvement in neurological deficit. Investigations revealed no evidence of systemic disease and this recurrence appears to be an isolated sanctuary site tumour. A MEDLINE search (1966 - present) of the literature failed to reveal similar reported cases and the authors believe this to be the first late intramedullary spinal cord metastasis in a patient with LBL.
authors.affiliation: Department of Neurosurgery, Dunedin Hospital, 201 Great King Street, Dunedin, New Zealand.
authors.forename: S
authors.initials: S
authors.lastname: Mathur
authors.forename: A J
authors.initials: AJ
authors.lastname: Law
authors.forename: N
authors.initials: N
authors.lastname: Hung
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome