Suppression of feed intake after parenteral administration of D-beta-hydroxybutyrate in pygmy goats.
The effect of intraperitoneal injection of D,L- or D-beta-hydroxybutyrate on feed intake and plasma metabolites was investigated in pygmy goats. The combined intraperitoneal injection of D,L-beta-hydroxybutyrate or D-beta-hydroxybutyrate (15 mmol/kg0.75) and 1,3-butanediol (6.6 mmol/kg0.75), a ketogenic substrate, decreased cumulative food intake while the same dose of 1,3-butanediol or DL-beta-hydroxybutyrate alone had no effect. The decrease in food intake after combined injection of D-beta-hydroxybutyrate and 1,3-butanediol was characterized by a significant decrease in meal frequency and a prolongation of the latency to eat. The hypophagic effect of the combined injection of D-beta-hydroxybutyrate and 1,3-butanediol was significant for 8 h, while the hypophagia after D,L-beta-hydroxybutyrate and 1,3-butanediol was significant for only 2 h after injection. Injection of D,L-beta-hydroxybutyrate increased plasma D-beta-hydroxybutyrate levels to 0.55 mmol/l and decreased plasma free fatty acids. Addition of 1,3-butanediol (6.6 mmol/kg0.75) to the injection increased plasma D-beta-hydroxybutyrate level up to 0.75 mmol/l. The results show that parenteral administration of D-hydroxybutyrate reduces feed intake in pygmy goats and that the hypophagia appears to be related to the amount of D-beta-hydroxybutyrate injected. The hypophagia seems to be related to elevated plasma D-beta-hydroxybutyrate concentration, and the threshold concentration appeared to be about 0.7 mmol/l under the experimental conditions of this study.
Rossi
R
R
Institut für Veterinärphysiologie, Veterinärmedizinische Fakultät, Universität Zürich, Switzerland.
Dörig
S
S
Del Prete
E
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Scharrer
E
E
D020155:3-Hydroxybutyric Acid / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002072:Butylene Glycols / Q000008:administration & dosage / Q000378:metabolism*; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D005227:Fatty Acids / Q000097:blood; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology; D005260:Female; D006041:Goats / Q000378:metabolism* / Q000502:physiology; D007274:Injections, Intraperitoneal / Q000662:veterinary; D013237:Stereoisomerism; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002072:Butylene Glycols; D005227:Fatty Acids; D014280:Triglycerides; C028491:1,3-butylene glycol; D020155:3-Hydroxybutyric Acid