title: Gene diversity of chimpanzee ABO blood group genes elucidated from intron 6 sequences.
abstract: The human and nonhuman primate ABO blood group gene shows relatively large numbers of nucleotide differences around the exon 7 region. In this study we determined intron 6 sequences for 9 alleles of common chimpanzee and for 3 alleles of bonobo to estimate nucleotide diversities among them. Sequence length polymorphisms are observed in this region as a repeat appears one to five times. From a phylogenetic network of intron 6 sequences of ABO blood group genes for humans, common chimpanzee, and bonobo, parallel substitutions and/or some kinds of convergent events are predicted in the chimpanzee lineage. We also estimated nucleotide diversities for common chimpanzee and bonobo ABO blood group genes; these values were 0.219% and 0.208%, respectively.
authors.affiliation: Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kitano
authors.forename: R
authors.initials: R
authors.lastname: Noda
authors.forename: K
authors.initials: K
authors.lastname: Sumiyama
authors.forename: R E
authors.initials: RE
authors.lastname: Ferrell
authors.forename: N
authors.initials: N
authors.lastname: Saitou
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D002679:Pan troglodytes / Q000235:genetics*; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
chemical_list: D000017:ABO Blood-Group System; D004247:DNA