title: Effects of oral administration of "rumen-bypass" vitamin D3 on vitamin D and calcium metabolism in periparturient cows.
abstract: Eleven late-pregnant Jersey cows were assigned to two groups; a group (PO-RBVD group) consisting of five cows treated with an oral administration of 10 million I.U. of an encapsulated form of vitamin D3 ("rumen-bypass" VD3; RBVD3) and another group (IMVD group) consisting of the other six treated with an intramuscular injection of 10 million I.U. of vitamin D3 (VD3). The cows received the RBVD3 or VD3 administration at 7 days before the expected parturition. The changes in the plasma concentrations of vitamin D metabolites, ionized Ca (Ca++) and inorganic phosphorus (iP) were evaluated. Of the vitamin D metabolites, the plasma 25-hydroxyvitamin D concentrations in PO-RBVD group increased significantly after the RBVD3 administration and remained in high levels that were significantly higher than those in IMVD group. This suggested that RBVD3 was absorbed rapidly and excellently from the post-ruminal digestive tract without the degradation by ruminal microorganisms. The plasma Ca++ and iP concentrations in PO-RBVD group tended to be higher after the administration and around parturition than those in IMVD group. From these observations, it was suggested the oral RBVD3 administration had more potent ability to prevent parturient paresis compared with the VD3 injection used widely in Japan.
authors.affiliation: Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Yamagishi
authors.forename: H
authors.initials: H
authors.lastname: Dohmae
authors.forename: A
authors.initials: A
authors.lastname: Shirato
authors.forename: J
authors.initials: J
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Naito
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007743:Labor, Obstetric / Q000378:metabolism*; D011247:Pregnancy; D012417:Rumen; D013997:Time Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism*
chemical_list: D014807:Vitamin D; D002762:Cholecalciferol; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium