Evidence for novel non-angiogenic pathway in breast-cancer metastasis. Breast Cancer Progression Working Party.
We have reported that angiogenic primary breast carcinoma can relapse not only as angiogenic, but also as non-angiogenic, lung metastases. This non-angiogenic pathway seems to be a novel pathway of cancer progression, and such tumours are likely to be resistant to antiangogenic treatment.
D001943:Breast Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply* / Q000556:secondary*; D008207:Lymphatic Metastasis; D009389:Neovascularization, Pathologic