title: Inhibition of rare earth catalytic activity by proteins.
abstract: Catalytic action of rare earth element, Ce(IV) to hydrolyze phosphomonoester bonds was confirmed. This effect was considered to suppress abiotic synthesis of nucleotides and nucleic acids in the primitive sea, and hence the origin of life. However, we found that the presence of proteins, especially albumin, strongly inhibited the catalytic action of Ce(IV). This finding was supported by preferential binding of rare earth elements (REEs) to proteins which was revealed using the radioisotopes of these REEs. Consequently, if a large amount of proteins was synthesized in the primitive sea, abiotic synthesis of phosphomonoester compounds, and hence nucleic acids, might have been possible.
authors.affiliation: Research Reactor Institute, Kyoto University, Sennan, Osaka, Japan. akaboshi@HL.rri.kyoto-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Akaboshi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Nakano
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: N
authors.initials: N
authors.lastname: Fujii
mesh_terms: D002384:Catalysis; D002586:Cesium / Q000037:antagonists & inhibitors*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D009696:Nucleic Acids / Q000096:biosynthesis; D009711:Nucleotides / Q000096:biosynthesis; D000069497:Origin of Life; D011506:Proteins / Q000494:pharmacology*; D013696:Temperature
chemical_list: D009696:Nucleic Acids; D009711:Nucleotides; D011506:Proteins; D002586:Cesium