title: Convergent C-glycolipid synthesis via the Ramberg-Bäcklund reaction: active antiproliferative glycolipids.
abstract: [formula: see text] A novel methodology has been developed, employing the Ramberg-Bäcklund rearrangement and ionic hydrogenation to synthesize C-glycosides with high stereoselectivity at the anomeric center. The C-glycolipid 14b exhibits antiproliferative properties similar to those of O-glycoside analogue 14a.
authors.affiliation: Department of Chemistry, Hunter College/CUNY, New York 10021, USA.
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: R W
authors.initials: RW
authors.lastname: Franck
authors.forename: H S
authors.initials: HS
authors.lastname: Byun
authors.forename: R
authors.initials: R
authors.lastname: Bittman
authors.forename: P
authors.initials: P
authors.lastname: Samadder
authors.forename: G
authors.initials: G
authors.lastname: Arthur
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D004354:Drug Screening Assays, Antitumor; D006017:Glycolipids / Q000138:chemical synthesis*; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006017:Glycolipids