[Detection of differences in liver protein composition between recombinant strains of mice with different ThioTEPA sensitivities].
The sensitivity of recombinant mouse strains subjected to 23-27 generations of inbreeding to the clastogenic effect of thioTEPA (triethylene thiophosphoramide) was reestimated, and their characteristics were confirmed. Six 1XC3 recombinant strains were obtained from crossing strains 101/H x C3H/Sn, which differed from one another with respect to the sensitivity to thioTEPA. The protein composition of the liver tissue was studied in the recombinant strains by means of two-dimensional electrophoresis. Interstrain differences with respect to five liver proteins were found, which were correlated with the differences in the response to the mutagen.
Malashenko
A M
AM
Research Laboratory of Experimental Biological Models, Russian Academy of Medical Sciences, Moscow oblast, Russia.
Beskova
T B
TB
Kovaleva
M A
MA
Kovalev
L I
LI
D000818:Animals; D004351:Drug Resistance / Q000235:genetics*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D011995:Recombination, Genetic; D013045:Species Specificity; D013852:Thiotepa / Q000494:pharmacology*
D009153:Mutagens; D011506:Proteins; D013852:Thiotepa