title: Steroid 5alpha-reductase inhibitory activity and hair regrowth effects of an extract from Boehmeria nipononivea.
abstract: The acetone extract of Boehmeria nipononivea showed both potent 5alpha-reductase inhibitory activity and hair regrowth promotion effects on mice. 5alpha-Reductase inhibitory activity-guided fractionation led to six active fatty acids: alpha-linolenic, linoleic, palmitic, elaidic, oleic and stearic acids. The extract of B. nipononivea, and alphalinolenic, elaidic and stearic acids exhibited a hair regrowth effect.
authors.affiliation: Department of Forest Products, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: R
authors.initials: R
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Shoyama
authors.forename: H
authors.initials: H
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Ueno
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000096:Acetone; D000505:Alopecia / Q000188:drug therapy*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005227:Fatty Acids / Q000627:therapeutic use*; D006197:Hair / Q000254:growth & development*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D019685:Rosales / Q000737:chemistry*
chemical_list: D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors; D005227:Fatty Acids; D010936:Plant Extracts; D000096:Acetone