[Immunological mechanisms of the radioprotective effects of ceruloplasmin].
The aim of the work was to examine immunotropic features of celluroplasmine++ (Cp) and estimate its capacity as radioprotector. The pulse radiolysis method was used to set the mechanism of elementary reactions, which were responsible for antioxidant activity, and to demonstrate a particular role of reversible oxycomplexis, Cp...O2. Within in vitro test-systems the effects of Cp were examined on the model of interaction between lymphocytes from Shelter staff which constantly contacts with ionizing irradiation, and autologous erythrocytes in rosset-forming phenomenon (223 Shelter employees in comparison with 253 donors of Kyiv blood transfucion station). Expression of this Index in the presence of antigens with known poly-specificity was determined (antigens were taken from cortical and pyramid sections of kidney, liver, lungs, myocard, pancreatic gland, grey matter and aorta). Simultaneously the presence of analogous autoantibodies was determined (ELISA). It has been shown that Cp can reprogram the level of expression of immunovaluable receptors towards to norm. It has been also defined that Cp presence in blood irradiated in vitro (1-15 rem) promotes the masking of active centers of autoantibodies of different tissue specificity.
Seniuk
O F
OF
ISTC Shelter National Academy of Sciences of Ukraine, Chernobyl.
Revina
A A
AA
Tarasenko
P D
PD
Kovalev
I F
IF
Seniuk
K V
KV
Korzh
S N
SN
D000975:Antioxidants; D015551:Autoimmunity / Q000187:drug effects; D002570:Ceruloplasmin / Q000276:immunology* / Q000494:pharmacology; D006386:Hemagglutination Tests; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000528:radiation effects*; D011848:Radioactive Pollutants / Q000009:adverse effects* / Q000276:immunology
D000975:Antioxidants; D011848:Radioactive Pollutants; D002570:Ceruloplasmin