Densitometric determination of impurities in pharmaceuticals. Part VI. Determination of 4,4-bis[4-(p-chlorophenyl)- 4-hydroxypiperidino]butyrophenone in haloperidol.
A chromatographic and densitometic method for identification and quantitative determination of 4,4-bis[4-(p-chlorophenyl)-4-hydroxypiperidino]butyrophenone as an impurity in haloperidol pharmaceutical has been developed. The HPTLC plates and chloroform-methanol-ammonium hydroxide 25% (90:9:1) were used for chromatographic separation as stationary and mobile phases respectively. Detection has been carried out in UV at lambda = 350 nm. The determination could be made directly without preliminary component separation by extraction. Based on the statistical analysis of obtained results, it was found that the new method is accurate and repeatable.
Krzek
J
J
Department of Inorganic and Analytical Chemistry, Collegium Medicum, Jagiellonian University, Kraków.
Maślanka
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D014150:Antipsychotic Agents / Q000032:analysis*; D002090:Butyrophenones / Q000032:analysis*; D003720:Densitometry; D004340:Drug Contamination; D006220:Haloperidol / Q000032:analysis*; D007202:Indicators and Reagents; D010880:Piperidines / Q000032:analysis*; D013607:Tablets
C410364:4,4-bis(4-chlorophenyl)-4-hydroxypiperidinobutyrophenone; D014150:Antipsychotic Agents; D002090:Butyrophenones; D007202:Indicators and Reagents; D010880:Piperidines; D013607:Tablets; D006220:Haloperidol