title: Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency.
abstract: A patient with chronic lymphocytic leukemia and an undetectable plasma level of protein S (PS), associated with recurrent venous thrombosis, is described. The laboratory investigation revealed the concomitant presence of an inhibitor directed to PS and a monoclonal protein in the patient's plasma. After treatment with prednisone and cyclophosphamide both the inhibitor to PS and the monoclonal component disappeared.
authors.affiliation: Institute of Haematology, University Clinical Center, Belgrade, Yugoslavia.
authors.forename: P
authors.initials: P
authors.lastname: Miljić
authors.forename: N
authors.initials: N
authors.lastname: Milosević-Jovicić
authors.forename: P
authors.initials: P
authors.lastname: Antunović
authors.forename: D
authors.initials: D
authors.lastname: Bosković
authors.forename: N
authors.initials: N
authors.lastname: Basara
authors.forename: Z
authors.initials: Z
authors.lastname: Rolović
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D018455:Protein S Deficiency / Q000097:blood / Q000209:etiology*; D012008:Recurrence; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D003520:Cyclophosphamide; D011241:Prednisone