The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation.
This article summarizes the structure, signal transduction and physiologic functions of the HGF/Met pathway, as well as its role in tumor growth, invasion, and metastasis. Moreover, it highlights recent studies indicating a role for the HGF/Met pathway in antigen-specific B-cell development and B-cell neoplasia.
van der Voort
R
R
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.
Taher
T E
TE
Derksen
P W
PW
Spaargaren
M
M
van der Neut
R
R
Pals
S T
ST
D000818:Animals; D000941:Antigens / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D002468:Cell Physiological Phenomena; D005314:Embryonic and Fetal Development; D004847:Epithelial Cells / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology; D017228:Hepatocyte Growth Factor / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D015448:Leukemia, B-Cell / Q000378:metabolism / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000378:metabolism / Q000473:pathology; D008648:Mesoderm / Q000166:cytology; D008958:Models, Molecular; D009024:Morphogenesis; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011487:Protein Conformation; D019859:Proto-Oncogene Proteins c-met / Q000737:chemistry / Q000502:physiology*; D051381:Rats; D015398:Signal Transduction; D014714:Vertebrates / Q000254:growth & development / Q000378:metabolism
D000941:Antigens; D019812:Heparan Sulfate Proteoglycans; D009363:Neoplasm Proteins; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met