title: Solid-phase enzymatic synthesis of oligonucleotides.
abstract: [formula: see text] The controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide.
authors.affiliation: Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Schmitz
authors.forename: M T
authors.initials: MT
authors.lastname: Reetz
mesh_terms: D017931:DNA Primers; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011130:RNA Ligase (ATP)
chemical_list: D017931:DNA Primers; D009841:Oligonucleotides; D011130:RNA Ligase (ATP)