[The dynamics of antigen-antibody complex formation in the presence of iodine-containing diagnostic agents].
A mathematical model is proposed to describe the antigen-antibody complex formation under the immunoassay conditions, which allows the antibody-antigen affinity to be evaluated. In particular, it is established that the dissociation constant of the antigen-antibody complex (for antibodies to a tuberculous Mycobacterium) confidently increases (p > 0.95) in the following sequence of diagnostic kits: omnipak > Ultravist > melitrast > Triombrast. The method suggested for analysis of the influence of xenobiotics upon the antigen-antibody reaction can be used to reveal their possible side effects on the antigen-antibody complex formation in any particular case.
Shabunin
I V
IV
Molecular Pharmacology and Radiobiology Chair, State Medical University, Moscow, Russia.
Panov
V O
VO
Avdienko
V V
VV
Shimanovskiĭ
N L
NL
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000187:drug effects; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000187:drug effects*; D000942:Antigens, Bacterial / Q000032:analysis / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology*; D004347:Drug Interactions; D007124:Immunoenzyme Techniques; D007455:Iodine / Q000494:pharmacology*; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000276:immunology
D000907:Antibodies, Bacterial; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D003287:Contrast Media; D007455:Iodine