title: New antimalarial and cytotoxic sungucine derivatives from Strychnos icaja roots.
abstract: Reinvestigation of Strychnos icaja Baillon resulted in the isolation of vomicine, isostrychnine and of three new sungucine derivatives, named isosungucine (8), 18-hydroxy-sungucine (9) and 18-hydroxy-isosungucine (10). They were identified by detailed spectroscopic methods. The complete 1H- and 13C-NMR study of sungucine was also realized. Some of these compounds were highly active against Plasmodium falciparum in vitro and more particularly against the chloroquine-resistant strain. Compound 10 showed a selective antiplasmodial activity, with > 100-fold greater toxicity towards Plasmodium falciparum, relative to cultured human cancer cells (KB and HeLa lines) or fibroblasts (WI38).
authors.affiliation: Department of Pharmacognosy, University of Liège, Belgium. M.Frederich@ulg.ac.be
authors.forename: M
authors.initials: M
authors.lastname: Frédérich
authors.forename: M C
authors.initials: MC
authors.lastname: De Pauw
authors.forename: G
authors.initials: G
authors.lastname: Llabrès
authors.forename: M
authors.initials: M
authors.lastname: Tits
authors.forename: M P
authors.initials: MP
authors.lastname: Hayette
authors.forename: V
authors.initials: V
authors.lastname: Brandt
authors.forename: J
authors.initials: J
authors.lastname: Penelle
authors.forename: P
authors.initials: P
authors.lastname: De Mol
authors.forename: L
authors.initials: L
authors.lastname: Angenot
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles