Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.
A new mycalamide, mycalamide D (3), has been isolated from the New Zealand marine sponge Mycale sp. This new metabolite, in which the C13-O-methyl group of mycalamide A (1) is replaced by a hydrogen atom, was found to be cytotoxic to a range of mammalian cell lines, with a potency approximately 20-fold less than that of 1.
West
L M
LM
School of Chemical and Physical Sciences, Victoria University of Wellington, New Zealand.
Northcote
P T
PT
Hood
K A
KA
Miller
J H
JH
Page
M J
MJ
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018374:LLC-PK1 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009520:New Zealand; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism; D013552:Swine; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D011714:Pyrans; C411311:mycalamide D