Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius.
To determine the somatic sensory modalities conveyed by hindlimb somatic afferent inputs, the discharge of neurons in the nucleus tractus solitarius was recorded in anesthetized rats after electrical stimulation of either the contralateral sciatic nerve or L(6) spinal nerve, which innervates the hindlimb. The discharge of seven of eight cells was increased (P < 0.05) by capsaicin injected into the arterial supply of the hindlimb. Discharge was unaltered in 19 neurons tested for sensitivity to nonnoxious (40 degrees C) and noxious (47 degrees C) heating of the hindlimb skin. In contrast, lightly stroking the skin elicited discharge in 2 of 14 cells, whereas noxious pinching increased activity in 4 other cells. Rhythmic (1- to 3-s) muscle contraction (MC) increased (P < 0.05) discharge in >60% of neurons tested (11 of 18). Static (10- to 30-s) MC significantly (P < 0.05) increased discharge in four cells, two of which were also responsive to rhythmic MC. Rhythmic and sustained muscle stretch increased discharge (P < 0.05) in three of eight neurons tested. These data indicate that nucleus tractus solitarius neurons receive input from low- and high-threshold cutaneous mechanoreceptors, respond to capsaicin delivered into the hindlimb arterial supply, lack thermal sensitivity, and respond to activation of mechanosensitive as well as metabosensitive endings in skeletal muscle.
Toney
G M
GM
Department of Physiology, The University of Texas Health Science Center at San Antonio, 78229-3900, USA. Toney@uthscsa.edu
Mifflin
S W
SW
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D004558:Electric Stimulation; D004594:Electrophysiology; D006614:Hindlimb / Q000294:innervation*; D006358:Hot Temperature; D007269:Injections, Intra-Arterial; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology; D012677:Sensation / Q000502:physiology*; D012879:Skin Physiological Phenomena; D017552:Solitary Nucleus / Q000502:physiology*
D002211:Capsaicin