T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis.
We describe a 17-year-old patient with a documented history of Crohn's disease (CD) and of minimal-change nephrotic syndrome (MCNS) in whom a diagnosis of T-cell acute lymphoblastic leukemia (ALL) was made. The diagnosis of ALL was established by morphological examination of bone-marrow aspirates and confirmed by means of immunophenotypic analysis showing the involvement of T-cell lineage leukemic cells. The lymphoid clone showed a karyotypic abnormality involving the long arm of chromosome 5 in a translocation (5;6). Few cases of CD complicated by ALL have been previously reported. The present one is the first case combining CD and ALL in a patient with a past history of MCNS. This raises the possibility of a relationship among those diseases. The possible mechanisms for such a relationship are discussed here.
Pérard
L
L
Service d'Anesthesie et de Réanimation, Hôpital Edouard Herriot, Lyon, France.
Thomas
X
X
Jaumain
H
H
Theuil
G
G
Bret
M
M
Coronel
B
B
Charrin
C
C
Boulétreau
P
P
D000293:Adolescent; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002895:Chromosomes, Human, Pair 5; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000235:genetics*; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000235:genetics*