title: Studies on anti-complementary activity of extracts and isolated flavones from Ligustrum vulgare and Phillyrea latifolia leaves (Oleaceae).
abstract: Polar fractions and flavones isolated from methanolic extracts of the leaves of Ligustrum vulgare and Phillyrea latifolia (Oleaceae), whose popular use as an anti-inflammatory is well-known in Mediterranean historical medicine and ethnobotany, showed significant in vitro complement inhibiting effect on the classical pathway of the complement system. Among the isolated flavonoidic structures, apigenin-7-O-glucoside, apigenin-7-O-rutinoside, luteolin-4'-O-glucoside, luteolin-7-O-glucoside and ligustroflavone presented remarkable activity.
authors.affiliation: Pharmazeutisches Institut der Rheinischen Friedrich-Wilhelms-Universität Bonn, Kreuzbergweg 26, D-53115, Bonn, Germany. experiences@netcologne.de
authors.forename: A
authors.initials: A
authors.lastname: Pieroni
authors.forename: P
authors.initials: P
authors.lastname: Pachaly
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: B
authors.initials: B
authors.lastname: Van Poel
authors.forename: A J
authors.initials: AJ
authors.lastname: Vlietinck
mesh_terms: D047310:Apigenin; D003169:Complement Inactivator Proteins / Q000494:pharmacology*; D003171:Complement Pathway, Classical / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D047311:Luteolin; D019083:Mediterranean Region; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D003169:Complement Inactivator Proteins; D005419:Flavonoids; D006027:Glycosides; D010936:Plant Extracts; C405585:ligustroflavone; D047310:Apigenin; D047311:Luteolin