Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases.
Clavilactones D and E were isolated from an agar culture of the Basidiomycetous fungus Clitocybe clavipes, and their structure was elucidated by 1H- and 13C-NMR studies. Clavilactone D is an inhibitor of tyrosine kinases.
Merlini
L
L
Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Italy. disma@unimi.it
Nasini
G
G
Scaglioni
L
L
Cassinelli
G
G
Lanzi
C
C
D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D002855:Chromatography, Thin Layer; D003470:Culture Media; D004591:Electrophoresis, Polyacrylamide Gel; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066246:ErbB Receptors / Q000378:metabolism; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared
D003470:Culture Media; D004791:Enzyme Inhibitors; D007783:Lactones; C412054:clavilactone D; C412055:clavilactone E; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases