title: Comparative analysis of proinflammatory cytokines in plasma of mice exposed to radiation or in combined radiation injury.
abstract: Male mice (CBA x C57BL/6)F1 were used for the experiments throughout this study. Blood serum levels of IL-1 beta, IL-6, TNF-alpha, IL-3, and GM-CSF were evaluated by means of enzyme-linked immunosorbent assay at 3, 6, 24, 48 and 72 hours after 7 Gy gamma-irradiation alone or combined injury (irradiation + thermal burn). Radiation as well as combined injury did not cause any important alterations of IL-1 beta, TNF-alpha, IL-3, and GM-CSF concentrations in the system circulation. Combined injury revealed more enhanced serum levels of IL-6 versus only irradiated mice. A possible significance of this phenomenon at the combined radiation and thermal burns' pathogenesis is discussed.
authors.affiliation: Medical Radiological Research Centre, Russian Academy of Medical Sciences, Obninsk. budagov@obninsk.com
authors.forename: R S
authors.initials: RS
authors.lastname: Budagov
authors.forename: L P
authors.initials: LP
authors.lastname: Ul'ianova
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood* / Q000276:immunology / Q000528:radiation effects; D007249:Inflammation / Q000097:blood / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000276:immunology
chemical_list: D016207:Cytokines