title: Angiomyolipoma mimicking true lipoma of the liver: report of two cases.
abstract: Hepatic angiomyolipoma (AML) is very rare and only about 80 cases have been reported. The tumor is fundamentally heterogeneously composed of the three tissue components of blood vessels, smooth muscle cells (SMC), and fat cells. Two cases of hepatic AML are reported here, both of which are histologically composed predominantly of a fat cell element and resembled true lipoma (lipomatous AML). However, careful examination of both tumors revealed the presence of a small amount of epithelioid SMC, especially around blood vessels. Immunohistochemical study using monoclonal antibody for melanoma (HMB-45) clearly revealed a small amount of HMB-45-positive SMC around the blood vessels and scattered in the diffuse fat cell growth in both tumors. Since no liver tissue components or primary liver tumors are reactive with HMB-45 except AML cells, the presence of HMB-45-positive cells within the tumor clearly established the diagnosis of hepatic AML. Any fatty tumor or focal fatty lesion of the liver that superficially resemble true lipomas should be tested for the presence of HMB-45-positive SMC in the tumor to differentiate it from AML.
authors.affiliation: Pathology Section, Kanazawa University Hospital, School of Medicine, Kanazawa University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Nonomura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizukami
authors.forename: K
authors.initials: K
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Kadoya
authors.forename: O
authors.initials: O
authors.lastname: Matsui
mesh_terms: D000368:Aged; D018207:Angiomyolipoma / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D000951:Antigens, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D008113:Liver Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D058950:Melanoma-Specific Antigens; D009130:Muscle, Smooth / Q000737:chemistry / Q000473:pathology; D009363:Neoplasm Proteins / Q000032:analysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D000951:Antigens, Neoplasm; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins