Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment.
Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.
Patel
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A
Department of Paediatric Intensive Care, Guy's Hospital, London, UK.
Harrison
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E
Durward
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Murdoch
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IA
D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D003850:Deoxyribonuclease I / Q000008:administration & dosage*; D005100:Expectorants / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome
D005100:Expectorants; D011994:Recombinant Proteins; D003850:Deoxyribonuclease I