[Nitric oxide, hemoglobin and laser irradiation].
The paper deals with the present views of some chemical properties and biological effects of nitric oxide (NO) and chiefly its formation and primary conversions. The interaction of NO with superoxide radical is shown to one of the most important reactions of the former, which gives rise to peroxynitrite whose breakdown yields a hydroxy radical. Emphasis is laid on the substances that are a temporary depot or a possible transport form of NO, such as nitrosothiols and nitrosyl complexes of non-hemic iron. NO is well-known to release when these compounds are degraded. It is suggested that hemoglobin is another NO depot, which forms stable complexes with the latter. These hemoglobin complexes may be degraded on exposure to laser radiation to form free NO that ha a vasodilatory effect. Photolysis of nitrosyl complexes of hemoglobin may be responsible for the therapeutical effect of laser radiation.
Osipov
A N
AN
Borisenko
G G
GG
Kazarinov
K D
KD
Vladimirov
Iu A
IuA
D000818:Animals; D006418:Heme / Q000528:radiation effects; D006454:Hemoglobins / Q000502:physiology* / Q000528:radiation effects; D006801:Humans; D053685:Laser Therapy; D009569:Nitric Oxide / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology* / Q000528:radiation effects; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011487:Protein Conformation / Q000528:radiation effects
D006454:Hemoglobins; D009569:Nitric Oxide; D006418:Heme; D019001:Nitric Oxide Synthase