title: [Detection of differences in liver protein composition between recombinant strains of mice with different ThioTEPA sensitivities].
abstract: The sensitivity of recombinant mouse strains subjected to 23-27 generations of inbreeding to the clastogenic effect of thioTEPA (triethylene thiophosphoramide) was reestimated, and their characteristics were confirmed. Six 1XC3 recombinant strains were obtained from crossing strains 101/H x C3H/Sn, which differed from one another with respect to the sensitivity to thioTEPA. The protein composition of the liver tissue was studied in the recombinant strains by means of two-dimensional electrophoresis. Interstrain differences with respect to five liver proteins were found, which were correlated with the differences in the response to the mutagen.
authors.affiliation: Research Laboratory of Experimental Biological Models, Russian Academy of Medical Sciences, Moscow oblast, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Malashenko
authors.forename: T B
authors.initials: TB
authors.lastname: Beskova
authors.forename: M A
authors.initials: MA
authors.lastname: Kovaleva
authors.forename: L I
authors.initials: LI
authors.lastname: Kovalev
mesh_terms: D000818:Animals; D004351:Drug Resistance / Q000235:genetics*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens / Q000494:pharmacology; D011506:Proteins / Q000235:genetics* / Q000378:metabolism*; D011995:Recombination, Genetic; D013045:Species Specificity; D013852:Thiotepa / Q000494:pharmacology*
chemical_list: D009153:Mutagens; D011506:Proteins; D013852:Thiotepa