title: Dose-related cardiovascular effects of isoflurane in chickens during controlled ventilation.
abstract: We studied cardiovascular effects of isoflurane in chickens during controlled ventilation. Following the determination of the minimal anesthetic concentration from the response to clamping of a digit, dose-related effect of isoflurane on heart rate and arterial pressure were studied. The minimal anesthetic concentration of isoflurane was 1.25 +/- 0.13% (mean +/- SD, n=9). There was a dose-dependent decrease in arterial pressure. The heart rate did not change significantly over a range of 1 to 2 times the minimal anesthetic concentration.
authors.affiliation: Department of Veterinary Science, Faculty of Agriculture, Miyazaki University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Naganobu
authors.forename: M
authors.initials: M
authors.lastname: Hagio
mesh_terms: D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D007530:Isoflurane / Q000008:administration & dosage / Q000494:pharmacology*; D012121:Respiration, Artificial
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane