Molecular insights into the immunopathogenesis of follicular lymphoma.
Follicular lymphoma is caused by the transformation of a germinal-center-derived B cell with a t(14;18) chromosomal translocation. The distribution of somatic mutations within immunoglobulin genes indicates that follicular-lymphoma cells can interact with antigen. In addition, nonimmunoglobulin genes such as BCL6 seem to undergo somatic hypermutation. Here, Kostas Stamatopoulos and colleagues relate the molecular data about immunoglobulin genes and the protooncogenes BCL2 and BCL6 to the pathogenesis and evolution of follicular lymphoma.
Stamatopoulos
K
K
First Department of Medicine, Athens University School of Medicine and Laikon General Hospital, Athens, Greece.
Kosmas
C
C
Belessi
C
C
Stavroyianni
N
N
Kyriazopoulos
P
P
Papadaki
T
T
D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D017637:Clonal Deletion; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D054278:Embryonal Carcinoma Stem Cells; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D018858:Germinal Center / Q000473:pathology; D006410:Hematopoiesis / Q000235:genetics; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D008224:Lymphoma, Follicular / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology; D018448:Models, Immunological; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology; D014411:Neoplastic Stem Cells / Q000276:immunology / Q000473:pathology; D016539:Reed-Sternberg Cells / Q000473:pathology; D014178:Translocation, Genetic; D045567:VDJ Recombinases
D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D009363:Neoplasm Proteins; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases