Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report.
The monoclonal immunoglobulin products of plasma cell neoplasm can give rise to a variety of manifestations including hyperviscosity, amyloidosis, cryoglobulinemia, neuropathy, and renal failure. A 50-year-old woman with monoclonal cryoglobulinemia developed extensive gangrene and ulceration of both hands and feet over several weeks requiring bilateral below-elbow and below-knee amputations. This case illustrates the importance of qualitative properties of paraprotein.
Sanmugarajah
J
J
Department of Medicine, Coney Island Hospital, Brooklyn, New York 11235, USA.
Hussain
S
S
Schwartz
J M
JM
Friedman
S
S
D000671:Amputation, Surgical; D003449:Cryoglobulinemia / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005528:Foot / Q000098:blood supply* / Q000601:surgery; D005734:Gangrene / Q000175:diagnosis* / Q000601:surgery; D006225:Hand / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis*
D007145:Immunoglobulin kappa-Chains