title: Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species.
abstract: Two novel human cytomegalovirus protease inhibitors, cytonic acids A (1) and B (2), have been isolated from the solid-state fermentation of the endophytic fungi Cytonaema sp. Their structures as p-tridepside isomers were elucidated by MS and NMR methods.
authors.affiliation: Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240. bingying@cnpr.nus.edu.sg
authors.forename: B
authors.initials: B
authors.lastname: Guo
authors.forename: J R
authors.initials: JR
authors.lastname: Dai
authors.forename: S
authors.initials: S
authors.lastname: Ng
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: C
authors.initials: C
authors.lastname: Leong
authors.forename: W
authors.initials: W
authors.lastname: Ong
authors.forename: B K
authors.initials: BK
authors.lastname: Carté
mesh_terms: D001565:Benzoates / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism*; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*
chemical_list: D001565:Benzoates; D011480:Protease Inhibitors; C410913:cytonic acid A; C410914:cytonic acid B; D012697:Serine Endopeptidases; C071910:assemblin