[Chronopharmacologic approach to the administration of anticancer agents in pancreatic adenocarcinoma. Pilot experience].
The authors first analyzed the potential interest of the delivery of anticancer agents according to chronobiological concepts for human pancreatic cancer. They report their experience on 41 patients treated in adjuvant (12 cases) or palliative (29 cases) situations. The excellent therapeutic index observed warrants further evaluations of this concept in randomized trials.
Focan
C
C
Service d'Oncologie médicale, Les Cliniques Saint-Joseph, Liège.
Kreutz
F
F
Focan-Henrard
D
D
Moeneclaey
N
N
Gillard
V
V
Delforge
M
M
Dallemagne
B
B
Weerts
J
J
Closon
M T
MT
Honoré
P
P
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D019454:Chronotherapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010865:Pilot Projects