The genetics of multiple sclerosis.
Classical genetic studies involving the analysis of pedigrees and recurrence risk within families have defined the extent to which genetic factors contribute to the aetiology of multiple sclerosis. Limited progress has been made in identifying the number and topography of genetic loci contributing to susceptibility through molecular investigation either of candidate genes or the whole genome using microsatellite and single nucleotide polymorphisms.
Compston
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University of Cambridge Neurology Unit, Addenbrooke's Hospital, UK.
D000483:Alleles; D005802:Genes, MHC Class II; D005819:Genetic Markers; D006801:Humans; D015810:Linkage Disequilibrium; D008285:Major Histocompatibility Complex; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology
D005819:Genetic Markers