Elevated plasma levels of 90K (Mac-2 BP) immunostimulatory glycoprotein in HIV-1-infected children.
90K is a secreted serum glycoprotein with immune stimulatory activity. In this study, 90K plasma levels were determined by an enzyme-linked immunosorbent assay in 18 HIV-1-infected children and 10 uninfected control children. 90K levels in HIV-1-infected children (median, 12.5 microg/ml) were higher than in HIV-1 uninfected control group (6.3 microg/ml; P < 0.05). 90K levels of HIV-1-infected children classified as stage B and C (median, 15.0 microg/ml and 22.7 microg/ml, respectively) were higher compared to children with stage A disease (median, 7.0 microg/ml; P < 0.05). A positive correlation (r = 0.5; P < 0.05) was found between 90K levels and HIV-1 RNA levels in 137 plasma samples of 18 HIV-1-infected children collected during a period of 1 year. No correlation was found between 90K levels and CD4 cell counts. These results suggest that 90K plasma levels may represent a novel marker of disease progression in HIV-1-infected children.
Gröschel
B
B
Institute of Medical Virology, Johann Wolfgang Goethe University, Frankfurt/M., Germany.
Braner
J J
JJ
Funk
M
M
Linde
R
R
Doerr
H W
HW
Cinatl
J
J
Iacobelli
S
S
D000276:Adjuvants, Immunologic / Q000097:blood*; D000293:Adolescent; D000943:Antigens, Differentiation / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D037502:Galectin 3; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000097:blood*; D008970:Molecular Weight; D012367:RNA, Viral / Q000097:blood
D000276:Adjuvants, Immunologic; D000943:Antigens, Differentiation; D037502:Galectin 3; D008562:Membrane Glycoproteins; D012367:RNA, Viral