fMRI shows multiple somatotopic digit representations in human primary somatosensory cortex.
Using electrical finger nerve stimulation in normal human subjects, fMRI detected separate representations for all 5 fingers in the primary somatosensory cortex. Responses were located in the posterior wall of the deep central sulcus (most likely corresponding to Brodmann Area (BA) 3b), and the anterior (BA 1) or posterior crown of the postcentral gyrus (BA 2) with rare activations in BA 3a and 4. In BA 3b we found a regular somatotopic mediolateral digit arrangement for fingers 5 to 1 with a mean Euclidean distance of 16 mm between fingers 1 and 5. In contrast BA 1/2 showed a greater number of adjacent activation foci with significantly more overlap and partly even reversed ordering of neighbouring fingers.
Kurth
R
R
Department of Radiology, Benjamin Franklin University Hospital, Free University, Berlin, Germany.
Villringer
K
K
Curio
G
G
Wolf
K J
KJ
Krause
T
T
Repenthin
J
J
Schwiemann
J
J
Deuchert
M
M
Villringer
A
A
D000328:Adult; D001931:Brain Mapping; D004558:Electric Stimulation; D005260:Female; D005385:Fingers / Q000294:innervation* / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013003:Somatosensory Cortex / Q000502:physiology*