title: Pythiosis with bone lesions in a pregnant mare.
abstract: A 9-year-old pregnant mare was referred for evaluation of a nonhealing wound of 8 weeks' duration on the lateral aspect of the left forelimb. A soft tissue mass encircled the proximal two thirds of the metacarpus; radiography revealed a moderate periosteal reaction affecting metacarpal bone i.v. Histologic and immunohistochemical examinations revealed eosinophilic granulomatous inflammation and Pythium sp in the soft tissues. The mare was treated for 12 days with antimicrobials, medicated wound dressings, debridement, and i.v. administration of sodium iodide; radiography revealed progression of the bone lesions. The mare was treated by regional arterial perfusion with miconazole and excision of affected soft tissues and the distal two thirds of metacarpal bone i.v. The mare recovered without complications and gave birth to a healthy foal. Regional perfusion of antifungal agents provides high concentrations in soft and osseous tissues and permits use of low dosages of agents administered by other routes, which reduces cost, adverse effects, and teratogenic effects.
authors.affiliation: Department of Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine, Kansas State University, Manhattan 66506-5606, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Worster
authors.forename: J D
authors.initials: JD
authors.lastname: Lillich
authors.forename: J H
authors.initials: JH
authors.lastname: Cox
authors.forename: B R
authors.initials: BR
authors.lastname: Rush
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001847:Bone Diseases / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy / Q000382:microbiology*; D006736:Horses; D008825:Miconazole / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D011775:Pythium / Q000302:isolation & purification*
chemical_list: D000935:Antifungal Agents; D008825:Miconazole