title: A case-control study after a hantavirus infection outbreak in the south of Belgium: who is at risk?
abstract: Puumala is the most common hantavirus serotype in Europe and is spread mainly by the red bank vole. Between 1 July 1992 and 31 January 1994, an outbreak of Puumala virus-induced nephropathia epidemica (NE) occurred in the Belgian Ardennes. Serologically confirmed cases (n = 41) were compared with two groups of asymptomatic seronegative controls. Risks identified included sighting of living rodents, exposure to rodent droppings, and trapping rodents during the 4 weeks preceding onset of symptoms. Activities during this 4-week period that presented the greatest risk were woodcutting, reopening of a nonaerated room, and strenuous physical effort. This is the first case-control study on risk factors for NE in Europe. In comparison with the American form of hantavirus pulmonary syndrome, which is spread by deer mice, professional activity appears to be a more important risk factor for acquisition of hantavirus in Europe.
authors.affiliation: Scientific Institute of Public Health-Louis Pasteur, Brussels, Belgium. f.vanloock@iph.fgov.be
authors.forename: F
authors.initials: F
authors.lastname: Van Loock
authors.forename: I
authors.initials: I
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Clement
authors.forename: S
authors.initials: S
authors.lastname: Ghoos
authors.forename: P
authors.initials: P
authors.lastname: Colson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001530:Belgium / Q000453:epidemiology; D016022:Case-Control Studies; D004196:Disease Outbreaks; D005260:Female; D006476:Orthohantavirus / Q000276:immunology*; D018778:Hantavirus Infections / Q000453:epidemiology* / Q000209:etiology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012377:Rodentia
chemical_list: D000914:Antibodies, Viral