Measles virus-specific T helper 1/T helper 2-cytokine production in subacute sclerosing panencephalitis.
Live measles virus-specific T helper 1/T helper 2-cytokine productions by peripheral blood mononuclear cells in response to live measles, mumps or varicella virus were measured in 15 patients with subacute sclerosing panencephalitis and 15 controls by enzyme-linked immunosorbent assays. Most patients with subacute sclerosing panencephalitis had a defect in measles virus-specific production of interferon-gamma, one of the T helper 1 type cytokines, despite persistent presence of measles virus, with preserved interleukin-10 (T helper 2 type cytokine) synthesis. Patients with subacute sclerosing panencephalitis were divided into two groups: responders (group A) with significant interferon-gamma production (>20 pg/mL) in response to live measles virus and non-responders (group B) with a little or no interferon-gamma production. Comparison of the clinical courses between groups A and B revealed that all the patients of group A retained receptive function for a long time, while most patients of group B lost the function rapidly (P<0.01). An inverse correlation between interferon-gamma production by peripheral blood mononuclear cells and disease progression suggested that interferon-gamma plays an antiviral role in subacute sclerosing panencephalitis.
Hara
T
T
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukyoka, Fukuoka, Japan.
Yamashita
S
S
Aiba
H
H
Nihei
K
K
Koide
N
N
Good
R A
RA
Takeshita
K
K
D000293:Adolescent; D000328:Adult; D019433:Chickenpox Vaccine / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007371:Interferon-gamma / Q000096:biosynthesis / Q000172:deficiency / Q000378:metabolism / Q000502:physiology*; D007378:Interleukins / Q000096:biosynthesis / Q000378:metabolism; D008222:Lymphokines / Q000096:biosynthesis* / Q000378:metabolism; D008297:Male; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology* / Q000472:pathogenicity; D009108:Mumps Vaccine / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000276:immunology* / Q000821:virology; D018417:Th1 Cells / Q000378:metabolism*; D018418:Th2 Cells / Q000378:metabolism*; D014613:Vaccines, Attenuated / Q000276:immunology
D019433:Chickenpox Vaccine; D007378:Interleukins; D008222:Lymphokines; D008458:Measles Vaccine; D009108:Mumps Vaccine; D014613:Vaccines, Attenuated; D007371:Interferon-gamma