title: Sudden bronchospasm on intubation: latex anaphylaxis?
abstract: I present a case of a patient with a history of cerebral palsy and asthma, living in a group home, who developed acute onset bronchospasm immediately after intubation. The patient developed hypotension 5 minutes after intubation. The bronchospasm lasted 20 minutes, and the case was complicated further by continued hypotension and a pneumothorax. A diagnosis of latex-mediated anaphylaxis was made in the intensive care unit after immunoglobin E (IgE), serum tryptase, and latex-specific IgE antibody were shown to be markedly elevated. This case report demonstrates that immediate onset of bronchospasm on intubation of an asthmatic patient is not always an asthma attack, and that other causes of bronchospasm should be considered in the differential diagnosis. Patients with a history of atopy, including those with a history of asthma, have an increased risk of developing latex sensitivity. It is important to remember that more than one etiology may be responsible for this kind of bronchospasm, and that it may be difficult to differentiate between multiple etiologies of bronchospasm.
authors.affiliation: Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. dhepner@zeus.bwh.harvard.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Hepner
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000150:complications*; D000906:Antibodies / Q000097:blood; D001249:Asthma / Q000150:complications; D001986:Bronchial Spasm / Q000209:etiology*; D002547:Cerebral Palsy / Q000150:complications; D053818:Chymases; D003937:Diagnosis, Differential; D006801:Humans; D007022:Hypotension / Q000209:etiology; D007073:Immunoglobulin E / Q000097:blood; D018836:Inflammation Mediators / Q000097:blood; D007442:Intubation, Intratracheal / Q000295:instrumentation*; D007840:Latex / Q000276:immunology; D020315:Latex Hypersensitivity / Q000150:complications*; D008297:Male; D011030:Pneumothorax / Q000209:etiology; D012697:Serine Endopeptidases / Q000097:blood; D053802:Tryptases
chemical_list: D000906:Antibodies; D018836:Inflammation Mediators; D007840:Latex; D007073:Immunoglobulin E; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases