title: Dose calculation and verification of intensity modulation generated by dynamic multileaf collimators.
abstract: While the development of inverse planning tools for optimizing dose distributions has come to a level of maturity, intensity modulation has not yet been widely implemented in clinical use because of problems related to its practical delivery and a lack of verification tools and quality assurance (QA) procedures. One of the prerequisites is a dose calculation algorithm that achieves good accuracy. The purpose of this work was twofold. A primary-scatter separation dose model has been extended to account for intensity modulation generated by a dynamic multileaf collimator (MLC). Then the calculation procedures have been tested by comparison with carefully carried out experiments. Intensity modulation is being accounted for by means of a 2D (two-dimensional) matrix of correction factors that modifies the spatial fluence distribution, incident to the patient. The dose calculation for the corresponding open field is then affected by those correction factors. They are used in order to weight separately the primary and the scatter component of the dose at a given point. In order to verify that the calculated dose distributions are in good agreement with measurements on our machine, we have designed a set of test intensity distributions and performed measurements with 6 and 20 MV photons on a Varian Clinac 2300C/D linear accelerator equipped with a 40 leaf pair dynamic MLC. Comparison between calculated and measured dose distributions for a number of representative cases shows, in general, good agreement (within 3% of the normalization in low dose gradient regions and within 3 mm distance-to-dose in high dose gradient regions). For absolute dose calculations (monitor unit calculations), comparison between calculation and measurement reveals good agreement (within 2%) for all tested cases (with the condition that the prescription point is not located on a high dose gradient region).
authors.affiliation: Service de Physique Médicale, Institut Curie, Paris, France. spiros.papatheodorou@curie.net
authors.forename: S
authors.initials: S
authors.lastname: Papatheodorou
authors.forename: J C
authors.initials: JC
authors.lastname: Rosenwald
authors.forename: S
authors.initials: S
authors.lastname: Zefkili
authors.forename: M C
authors.initials: MC
authors.lastname: Murillo
authors.forename: J
authors.initials: J
authors.lastname: Drouard
authors.forename: G
authors.initials: G
authors.lastname: Gaboriaud
mesh_terms: D000465:Algorithms; D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D010315:Particle Accelerators / Q000295:instrumentation / Q000706:statistics & numerical data; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000706:statistics & numerical data*; D020266:Radiotherapy, Conformal / Q000295:instrumentation / Q000706:statistics & numerical data; D011882:Radiotherapy, High-Energy / Q000295:instrumentation / Q000706:statistics & numerical data; D012542:Scattering, Radiation