title: Single-motor mechanics and models of the myosin motor.
abstract: Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.
authors.affiliation: Exploratory Research for Advanced Technology, Japan Science and Technology Corporation, Mino, Osaka. yanagida@physl.med.osaka-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Yanagida
authors.forename: S
authors.initials: S
authors.lastname: Esaki
authors.forename: A H
authors.initials: AH
authors.lastname: Iwane
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: A
authors.initials: A
authors.lastname: Ishijima
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Tokunaga
mesh_terms: D000199:Actins / Q000737:chemistry / Q000502:physiology; D000205:Actomyosin / Q000737:chemistry / Q000502:physiology; D000818:Animals; D001696:Biomechanical Phenomena; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000737:chemistry / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D009218:Myosins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
chemical_list: D000199:Actins; D020409:Molecular Motor Proteins; D000205:Actomyosin; D009218:Myosins