Plasma amino acid profile on nocturnal hemodialysis.
OBJECTIVE
The purpose of this study was to examine the effect of nocturnal hemodialysis (NHD) on serum amino acid (AA) profile.


METHODS
In a cross-over trial, we studied the AA profile in 11 patients who were switched from conventional hemodialysis to NHD. Plasma levels of AA were measured at monthly intervals for a period of 1 year.


RESULTS
Concentrations of AA isoleucine, threonine, phenylalanine, valine, glycine, glutamine and taurine increased on switch to NHD. Total AA (2,907.2 +/- 542.2 vs. 3,870.2 +/- 715.2 micromol/l, p = 0.03), essential AA (EAA, 842.2 +/- 259.4 vs. 1,125. 8 +/- 235.3 micromol/l, p = 0.03), nonessential AA (NEAA, 2,307.2 +/- 399.1 vs. 2,879.5 +/- 581.2 micromol/l, p = 0.03), and branched chain AA (315.5 +/- 90.8 vs. 386.0 +/- 114.3 micromol/l, p = 0.05) concentrations were significantly higher on NHD. However, abnormalities in the ratios of EAA/NEAA, valine/glycine and tyrosine/phenylalanine persisted during NHD.


CONCLUSIONS
NHD alleviated some abnormalities in the aminogram of uremia, but other metabolic derangements lingered.
Raj
D S
DS
Humber River Regional Hospital, University of Toronto, Ont., Canada.
Ouwendyk
M
M
Francoeur
R
R
Pierratos
A
A
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001639:Bicarbonates / Q000097:blood; D001835:Body Weight; D018592:Cross-Over Studies; D005260:Female; D006437:Hemodialysis, Home / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009551:Night Care / Q000379:methods / Q000592:standards*; D009752:Nutritional Status; D011446:Prospective Studies; D011506:Proteins / Q000378:metabolism; D051437:Renal Insufficiency / Q000628:therapy; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
D000596:Amino Acids; D001639:Bicarbonates; D011506:Proteins; D012709:Serum Albumin