title: Electrospray ionisation-mass spectrometric characterisation of selected anti-psychotic drugs and their detection and determination in human hair samples by liquid chromatography-tandem mass spectrometry.
abstract: Electrospray ionisation quadrupole ion-trap mass spectrometric (ESI-MS) characterisation of the anti-psychotic drugs chlorpromazine, trifluoperazine, flupenthixol, risperidone and the antidepressant/internal standard trimipramine is presented and possible mechanisms for the observed MSn fragmentation patterns proposed. A validated liquid chromatography (LC)-MS-MS method is then applied to the detection and determination of these drugs in the hair of a patient under clinical treatment for schizophrenia. Chlorpromazine, trifluoperazine and flupenthixol are identified and determined in this hair sample following alkaline degradation of the matrix, solvent extraction and LC-MS-MS using trimipramine as internal standard.
authors.affiliation: School of ABCS, University of Ulster, Coleraine, Northern Ireland, UK.
authors.forename: S
authors.initials: S
authors.lastname: McClean
authors.forename: E J
authors.initials: EJ
authors.lastname: O'Kane
authors.forename: W F
authors.initials: WF
authors.lastname: Smyth
mesh_terms: D014150:Antipsychotic Agents / Q000032:analysis* / Q000378:metabolism; D002138:Calibration; D002853:Chromatography, Liquid; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007202:Indicators and Reagents; D013058:Mass Spectrometry; D012559:Schizophrenia / Q000378:metabolism; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
chemical_list: D014150:Antipsychotic Agents; D007202:Indicators and Reagents