title: New synthetic vitamin D analogs with antiproliferative activities.
abstract: The introduction of oxygen atoms into different positions of the vitamin D side chain is described. By combining the arising 23-oxa and 25-oxa elements with other structural modifications (19-nor, iso-19-nor, 20-methyl, 20-ene, 20,21-cyclo) calcitriol analogs with remarkable levels of dissociation between beneficial acitivities on cell growth regulation and undesired hypercalcemia were identified. Structure-activity relations are elaborated in a very systematic outline of the Schering drug finding program in this particular class of vitamin D compounds.
authors.affiliation: Schering AG, Institute of Medicinal Chemistry, Berlin, D-13342, Germany. andreas.steinmeyer@schering.de
authors.forename: A
authors.initials: A
authors.lastname: Steinmeyer
authors.forename: G
authors.initials: G
authors.lastname: Kirsch
authors.forename: G
authors.initials: G
authors.lastname: Neef
authors.forename: K
authors.initials: K
authors.lastname: Schwarz
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002117:Calcitriol / Q000031:analogs & derivatives*; D002455:Cell Division / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D002117:Calcitriol