title: [An analysis of 3H-tamoxifen binding with the cell plasma membranes of the rat uterus].
abstract: The effect of phencarol, ranitidine, propranolol, atropine, and diethylstilbestrol (known as modulators of the tamoxifen-binding sites in plasma membranes) on the 3H-tamoxifen binding to the plasma membrane fraction of white rat uterine cells was studied by determining the amounts of estradiol and H1- and H2-receptors. The interaction of tamoxifen with various receptors of uterine cells may be significant for evaluation of the tumor activity of this compound.
authors.affiliation: Molecular Pharmacology and Radiobiology Chair, State Medical University, Moscow, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Kareva
authors.forename: E V
authors.initials: EV
authors.lastname: Solov'eva
authors.forename: N V
authors.initials: NV
authors.lastname: Kirpichnikova
authors.forename: A V
authors.initials: AV
authors.lastname: Tumanov
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Rybalko
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000493:pharmacokinetics*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D008024:Ligands; D051381:Rats; D011959:Receptors, Estradiol / Q000187:drug effects / Q000378:metabolism; D018709:Statistics, Nonparametric; D013629:Tamoxifen / Q000493:pharmacokinetics*; D014316:Tritium; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D008024:Ligands; D011959:Receptors, Estradiol; D013629:Tamoxifen; D014316:Tritium