title: Effect of arthrocentesis and sodium hyaluronate injection on nitrite, nitrate, and thiobarbituric acid-reactive substance levels in the synovial fluid.
abstract: OBJECTIVE
  To evaluate the effect of arthrocentesis and sodium hyaluronate (SH) injections on nitrite, nitrate, and thiobarbituric acid-reactive substance (TBA-RS) levels in temporomandibular joint internal derangements.
  
  
  METHODS
  Arthrocentesis was performed on 10 patients, and 15 patients received a supplemental injection of SH after arthrocentesis. All these patients received an SH injection 15 days after the first intervention. The synovial fluid samples were obtained before arthrocentesis on the first appointment and before the SH injection 15 days later. Nitrite and nitrate levels were measured with a highly sensitive and specific chemiluminescence detection method, and the concentration of lipid peroxidation products was assessed by means of the thiobarbituric acid reaction.
  
  
  RESULTS
  Symptomatic improvement was seen in both groups. Nitrite, nitrate, and TBA-RS levels only decreased significantly (P <.05) with a supplemental SH injection after arthrocentesis.
  
  
  CONCLUSIONS
  Intra-articular injections of SH may reduce nitrite, nitrate, and TBA-RS levels that play a role in the pathogenesis of various temporomandibular disorders.
authors.affiliation: Gazi University, Department of Oral and Maxillofacial Surgery, Ankara, Turkey. alpaslan@tr-net.net.tr
authors.forename: C
authors.initials: C
authors.lastname: Alpaslan
authors.forename: A
authors.initials: A
authors.lastname: Bilgihan
authors.forename: G H
authors.initials: GH
authors.lastname: Alpaslan
authors.forename: B
authors.initials: B
authors.lastname: Güner
authors.forename: M
authors.initials: M
authors.lastname: Ozgür Yis
authors.forename: D
authors.initials: D
authors.lastname: Erbaş
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007270:Injections, Intra-Articular; D008875:Middle Aged; D009566:Nitrates / Q000378:metabolism*; D009573:Nitrites / Q000378:metabolism*; D019152:Paracentesis; D013582:Synovial Fluid / Q000187:drug effects / Q000378:metabolism*; D013704:Temporomandibular Joint / Q000601:surgery*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism / Q000628:therapy*; D007507:Therapeutic Irrigation; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D009566:Nitrates; D009573:Nitrites; D017392:Thiobarbituric Acid Reactive Substances; D006820:Hyaluronic Acid