Heart transplantation for radiation-associated end-stage heart failure.
Radiation-induced heart disease is an increasingly recognized late sequela of mediastinal radiation therapy for malignant neoplasms. We report four cases of heart transplantation for end-stage heart failure induced by mediastinal radiation therapy. Short-term and intermediate-term results are excellent with all four patients currently surviving a mean of 48 months after transplantation. Neither a second malignancy nor recurrence of the primary malignancy has been observed to date. The early results of heart transplantation for end-stage, radiation-induced heart disease are encouraging.
Handa
N
N
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
McGregor
C G
CG
Daly
R C
RC
Dearani
J A
JA
Edwards
B S
BS
Frantz
R P
RP
Olson
L J
LJ
Rodeheffer
R J
RJ
D000328:Adult; D002303:Cardiac Output, Low / Q000209:etiology* / Q000601:surgery*; D002648:Child; D016027:Heart Transplantation; D019337:Hematologic Neoplasms / Q000150:complications / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D014184:Transplantation, Homologous