Chloride transport by lobster hepatopancreas is facilitated by several anion antiport mechanisms.
Three anion antiporters have previously been demonstrated in lobster hepatopancreatic basolateral membrane vesicles (BLMV) to perform vital physiological functions in the crustacean. Cl(-) was shown to be transported by all three of the documented antiporters. The stilbene, 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid, also known as SITS, strongly inhibited Cl(-)/SO(4)(2-), Cl(-)/oxalate(2-) and Cl(-)/HCO(3)(-) exchange. It was concluded that Cl(-) could be transported by different modes of the documented existing anion antiporters in the lobster hepatopancreatic BLMV.
Gerencser
G A
GA
Department of Physiology, College of Medicine, Box 100274, JHMHC, University of Florida, Gainesville, FL 32610, USA.
Ahearn
G A
GA
Robbins
F
F
Cattey
M A
MA
D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology; D000818:Animals; D000838:Anions; D017920:Antiporters / Q000037:antagonists & inhibitors / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D002712:Chlorides / Q000378:metabolism*; D004064:Digestive System / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D008121:Nephropidae / Q000502:physiology*
D000838:Anions; D017920:Antiporters; D002712:Chlorides; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid