title: Enhancing effect of dietary oil emulsions on immune responses to protein antigens fed to mice.
abstract: Repeated intragastric administration of beta-lactoglobulin (beta-Lg) with emulsified soybean oil elicited an antigen-specific, systemic humoral immune response in different strains of mice. The antibody response was enhanced as the dose of oil was increased and the particle size of emulsions was decreased. Feeding of aqueous beta-Lg could induce the antibody response only when emulsified oil was fed almost simultaneously. However, the emulsion-driven humoral immune response was not observed when mice were treated with anti-CD40 ligand antibody or in athymic mice. It is likely that the intestinal coexistence of emulsified oil with dietary antigens modulates the immune system to crucially support B cell response. A practical application of the present results to the prevention of cow's milk protein sensitization in infants is proposed.
authors.affiliation: Nutrition Science Institute, Meiji Milk Products, Co., Ltd., Tokyo, Japan. tetsuo_kaneko@meiji-milk.com
authors.forename: T
authors.initials: T
authors.lastname: Kaneko
authors.forename: Y
authors.initials: Y
authors.lastname: Terasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Senoo
authors.forename: M
authors.initials: M
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Kuwata
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004655:Emulsions / Q000008:administration & dosage; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood*; D007782:Lactoglobulins / Q000008:administration & dosage* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D010316:Particle Size; D013024:Soybean Oil / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D004655:Emulsions; D007074:Immunoglobulin G; D007782:Lactoglobulins; D013024:Soybean Oil