Application of base cleavable safety catch linkers to solid phase library production.
We have used sulfide "Safety Catch" linkers to anchor typical medicinal chemistry functional groups to amine resins. Compounds are loaded as the ester, carbamate, or amine. At the end of the synthesis, the linker is activated by peracid. The sulfone resins are then cleaved by beta-elimination in the gas phase or in solution by secondary amines to produce acids and primary, secondary, or tertiary amines. Comparison of cleavage rates to other sulfone resins including SEM showed significantly faster cleavage for this system with conditions similar to Fmoc deprotection. Application of this strategy to a medicinal chemistry library gives good yields and purities of the resulting compounds.
Wade
W S
WS
Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-3500, USA.
Yang
F
F
Sowin
T J
TJ
D002626:Chemistry, Pharmaceutical; D020650:Combinatorial Chemistry Techniques; D006868:Hydrolysis; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry