title: Management and outcome of glottic cancer: a population-based comparison between Ontario, Canada and the SEER areas of the United States. Surveillance, Epidemiology and End Results.
abstract: OBJECTIVE
  We compared treatment practice and outcome in glottic cancer in Ontario, Canada to that in the Surveillance, Epidemiology and End Results (SEER) program areas in the United States to determine whether the Ontario emphasis on the use of delayed combined therapy was associated with similar survival and better laryngectomy-free survival than the U.S. approach, which emphasizes greater use of surgery.
  
  
  METHODS
  Electronic, clinical, and hospital data were linked to cancer registry data. The study groups compared on survival comprised all patients diagnosed from 1982 to the end of 1991 in Ontario (2324 patients) and in the SEER areas (5715 patients). Comparisons on initial treatment, laryngectomy rates, and laryngectomy-free survival were limited to subsets of these study populations due to data availability. Initial treatment data were provided by the SEER registries in the U.S. and by the cancer clinic and hospitalization data in Ontario. Information about laryngectomies performed subsequent to initial treatment was available from Medicare hospitalization data in the U.S. and from Canadian Institute for Health Information hospitalization data in Ontario.
  
  
  RESULTS
  Although radiotherapy was the most common initial treatment in both areas, it was used more often in Ontario (84.4% versus 63.2% in the U.S. [p < 0.001]). Relative survival was not statistically different with a relative risk comparing SEER to Ontario of 1.09, 95% confidence interval (CI) (0.93, 1.29). Laryngectomy rates were similar with a relative risk of 1.01, 95% CI (0.67, 1.52), and it follows from the survival and laryngectomy rate comparisons that the laryngectomy-free survival was not statistically different (p = .95).
  
  
  CONCLUSIONS
  There are large differences in the management of glottic cancer between the U.S. and Ontario and no corresponding differences in survival or laryngectomy-free survival. This work highlights a need for more clinical investigation into the relative merits of differing management policies in glottic cancer.
authors.affiliation: Department of Oncology, Queen's University, Kingston, Ontario.
authors.forename: P A
authors.initials: PA
authors.lastname: Groome
authors.forename: W J
authors.initials: WJ
authors.lastname: Mackillop
authors.forename: D M
authors.initials: DM
authors.lastname: Rothwell
authors.forename: B
authors.initials: B
authors.lastname: O'Sullivan
authors.forename: J C
authors.initials: JC
authors.lastname: Irish
authors.forename: S F
authors.initials: SF
authors.lastname: Hall
authors.forename: P R
authors.initials: PR
authors.lastname: Warde
authors.forename: E J
authors.initials: EJ
authors.lastname: Holowaty
mesh_terms: D000368:Aged; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009864:Ontario; D015996:Survival Rate; D016896:Treatment Outcome; D014481:United States