title: Acute gastrointestinal bleeding in the intensive care unit. The gastroenterologist's perspective.
abstract: Although SRES-associated hemorrhage previously constituted a significant cause of bleeding in the ICU, improvements in ICU management and the institution of prophylactic measures in high-risk patients have significantly reduced SRES-associated hemorrhage since the 1980s. Antacids, H2-receptor antagonists, and sucralfate have been shown to be effective in preventing clinically significant bleeding resulting from SRES, particularly when the intragastric pH is maintained at greater than 4. A selective approach should be adopted in SRES prophylaxis: Patients on mechanical ventilation, with coagulopathy, or with two of the other known risk factors should receive prophylaxis. Although the drug of choice depends to some extent on local preferences, an H2-receptor antagonist by continuous intravenous infusion may represent the best option. No pharmacologic therapy is of proven value once hemorrhage begins, but the current interventional techniques are effective in controlling hemorrhage. Gastrointestinal bleeding from NOMV has become less common with improvements in the hemodynamic monitoring of critically ill patients, but this disease must always be considered when lower gastrointestinal bleeding occurs in the context of relative hypoperfusion. For SRES and NOMV, treatment of the underlying disease or diseases is the optimal route to prevention.
authors.affiliation: Section of Gastroenterology, Boston University School of Medicine, Massachusetts, USA.
authors.forename: U
authors.initials: U
authors.lastname: Beejay
authors.forename: M M
authors.initials: MM
authors.lastname: Wolfe
mesh_terms: D000208:Acute Disease; D002983:Clinical Competence; D005762:Gastroenterology / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D007362:Intensive Care Units; D008638:Mesenteric Arteries; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D017410:Practice Guidelines as Topic; D012151:Resuscitation / Q000379:methods*; D013312:Stress, Physiological / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome