Efficient synthesis of a porphyrin-N-tripod conjugate with covalently linked proximal ligand: toward new-generation active-site models of cytochrome c oxidase.
[formula: see text] A new-generation cytochrome c oxidase active-site model compound (4) featuring both a trisimidazolyl moiety and a proximal base has been designed and efficiently synthesized. During this study, a facile method based on the chemistry of a 4-magnesioimidazole derivative to synthesize 4-imidazolyl-containing tripodal ligands (7) has been developed.
Collman
J P
JP
Department of Chemistry, Stanford University, California 94305-5080, USA. jpc@chem.stanford.edu
Zhong
M
M
Wang
Z
Z
Rapta
M
M
Rose
E
E
D001665:Binding Sites; D003576:Electron Transport Complex IV / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D011166:Porphyrins / Q000138:chemical synthesis*
D008024:Ligands; D011166:Porphyrins; D003576:Electron Transport Complex IV