Morphological changes in mouse accessory sex glands following neonatal estrogen treatment.
A single injection of beta-estradiol 17-cypionate into the mice within 5 hr after birth induced inflammation in all prostate lobes and the seminal vesicles. Neutrophils emigrated into the lumen through the basal lamina and epithelium of the seminal vesicle and the anterior prostate. Local infiltration of lymphocytes was observed in the stroma and epithelium of ventral prostates. Lymphocytes penetrated through smooth muscle cells into epithelium. This could support the hypothesis that smooth muscle cells are the target of the estrogen action of prostates in estrogenized animals.
Kawamura
H
H
Department of Anatomy, Aichi Medical University, Japan.
Nonogaki
T
T
Yoshikawa
K
K
Kimura
M
M
Ichihara
I
I
Nakano
T
T
D000818:Animals; D000831:Animals, Newborn; D004847:Epithelial Cells / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007249:Inflammation; D008214:Lymphocytes / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009130:Muscle, Smooth / Q000187:drug effects / Q000503:physiopathology; D009504:Neutrophils / Q000187:drug effects / Q000473:pathology; D011467:Prostate / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D012669:Seminal Vesicles / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology
D004958:Estradiol; C007630:estradiol 17 beta-cypionate