title: Integrating biological and behavioral factors in alcohol use risk: the role of ALDH2 status and alcohol expectancies in a sample of Asian Americans.
abstract: Prior studies have shown that the ALDH2*2 genetic variant, most common in individuals of Asian descent, is related to heightened sensitivity to alcohol and can serve as a protective factor against alcohol problems. This study explored the effect of this factor on alcohol expectancies. It was hypothesized that (a) individuals with ALDH2*2 alleles would have lower positive expectancies and higher negative expectancies, (b) expectancies would mediate the ALDH2-drinking relation, and (c) ALDH2 status would moderate the expectancy-drinking relation. Data were collected from 171 Asian American university students. Positive expectancy and ALDH2 status were correlated with alcohol use. Mediation and moderation hypotheses were supported only in the female sample. Results were not significant for negative expectancies. These results indicate that ALDH2 status may protect against drinking by lowering positive expectancies and reducing the expectancy-drinking relationship.
authors.affiliation: Department of Psychiatry, University of California, San Diego, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: McCarthy
authors.forename: T L
authors.initials: TL
authors.lastname: Wall
authors.forename: S A
authors.initials: SA
authors.lastname: Brown
authors.forename: L G
authors.initials: LG
authors.lastname: Carr
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics* / Q000523:psychology*; D000444:Aldehyde Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D001213:Asian; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012044:Regression Analysis; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol; D000444:Aldehyde Dehydrogenase