Leu-enkephalin induced by IL-2 administration mediates analgesic effect of IL-2.
Interleukin-2 (IL-2) was found to have an analgesic effect in both central and peripheral nervous systems. This effect is related to opioid receptors and mediated mainly by IL-2 directly binding to opioid receptors. Using radioimmunoassay, the content of Leu-enkephalin (LEK) in some nuclei were measured at intervals after the injection of IL-2 into the lateral ventricle of rats. Levels of LEK increased in both paraventricular hypothalamic nucleus (PVN) and locus ceruleus (LOC) after IL-2 administration, suggesting that the analgesic effect of IL-2 is also related to the change of LEK in PVN and LOC induced by IL-2 administration.
Jiang
C L
CL
Department of Neurobiology, Second Military Medical University, Shanghai, PR China.
You
Z D
ZD
Lu
C L
CL
Xu
D
D
Wang
A J
AJ
Wang
Y X
YX
Liu
X Y
XY
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004743:Enkephalin, Leucine / Q000378:metabolism*; D006801:Humans; D007276:Injections, Intraventricular; D007376:Interleukin-2 / Q000494:pharmacology*; D020547:Lateral Ventricles; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D015213:Neuroimmunomodulation / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects*; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011957:Receptors, Opioid / Q000502:physiology
D000700:Analgesics; D007376:Interleukin-2; D009292:Narcotic Antagonists; D011957:Receptors, Opioid; D009270:Naloxone; D004743:Enkephalin, Leucine