[The effect of Clexane (low-molecular-weight heparin) on the hemostatic system and on the incidence of postoperative thrombotic complications in gynecological cancer patients].
Clexane in a dose of 40 mg before and after surgery notably decreased the intensity of chronic intravascular blood coagulation during surgical treatment of oncogynecological patients. Only 3% patients developed thrombosis of deep veins of the lower limbs after Clexane, while in the group administered no Clexane, 20% developed this complication. Preventive administration of Clexane did not cause an increase of the operative blood loss. The incidence of wound hematomas in patients administered Clexane and nonfractionated heparin was negligible and virtually the same.
Madzhuga
A V
AV
Somonova
O V
OV
Kononenko
L P
LP
Gorobets
E S
ES
Elizarova
A L
AL
Astakhova
V M
VM
D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical / Q000517:prevention & control; D017984:Enoxaparin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005833:Genital Neoplasms, Female / Q000097:blood / Q000150:complications* / Q000601:surgery; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D013997:Time Factors
D017984:Enoxaparin; D005343:Fibrinolytic Agents