[The evaluation of the specific activity and side effects of the m-cholinergic blocker pentifin compared to other antiparkinson agents].
Experiments on rodents showed that pentifin, a muscarine antagonist belonging to the group of acetylene amines, possesses a pronounced antiparkinsonian activity. Pentifin is superior in the breadth of therapeutic action and tolerance characteristics to the conventional agents used for Parkinson's disease treatment.
Khrabrova
A V
AV
Institute of Toxicology, Ministry of Public Health of the Russian Federation, St. Petersburg, Russia.
Zagrebin
A O
AO
Kosmachev
A B
AB
Kubarskaia
L G
LG
Lychakov
A V
AV
Libman
N M
NM
Savateeva
T N
TN
Titkova
T A
TA
Tonkopiĭ
V D
VD
Fil'ko
O A
OA
Khobotova
Z I
ZI
D000114:Acetylene / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D000588:Amines / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D003292:Convulsants; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004353:Drug Evaluation, Preclinical; D006220:Haloperidol; D006339:Heart Rate / Q000187:drug effects; D007928:Lethal Dose 50; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D018727:Muscarinic Antagonists / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use* / Q000633:toxicity; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D000588:Amines; D000978:Antiparkinson Agents; D003292:Convulsants; D018727:Muscarinic Antagonists; D006220:Haloperidol; D000114:Acetylene; D010433:Pentylenetetrazole