Nuclear magnetic relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation.
Nuclear Magnetic Relaxation field-cycling relaxometry is a technique, able to report on water mobility in tissues. By means of this technique, post-mortem specimens from both controls and idiopathic Parkinson's disease patients have been investigated. Results show different relaxometric behavior between the groups, which is consistent with protein aggregation in Parkinson's disease specimens.
Lopiano
L
L
Department of Neuroscience, University of Torino, Italy. fasano@ch.unito.it
Fasano
M
M
Giraudo
S
S
Digilio
G
G
Koenig
S H
SH
Torre
E
E
Bergamasco
B
B
Aime
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D010300:Parkinson Disease / Q000378:metabolism*; D011180:Postmortem Changes; D012996:Solutions; D013378:Substantia Nigra / Q000737:chemistry*; D013696:Temperature; D014867:Water
D009419:Nerve Tissue Proteins; D012996:Solutions; D014867:Water