title: Double role of HLA in organ transplantation.
abstract: Although HLA matching can improve organ graft survival, well matched grafts fail and poorly matched ones survive. Recently evidence has been found that perinatal exposure to noninherited antigens (NIMAs) has a lifelong impact on the immune repertoire of the individual. The state of the art of the influence of NIMAs on graft survival is summarized. These findings could lead to a better understanding of the allograft reaction.
authors.affiliation: Europdonor Foundation, Leiden University Medical Centre, Leiden, The Netherlands. vanrood@rullf2.leidenuniv.nl
authors.forename: J J
authors.initials: JJ
authors.lastname: van Rood
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000502:physiology*; D006650:Histocompatibility Testing; D006801:Humans; D016377:Organ Transplantation; D010641:Phenotype
chemical_list: D006680:HLA Antigens