A new primate model for multiple sclerosis in the common marmoset.
Experimental autoimmune encephalomyelitis (EAE) in outbred marmoset monkeys (Callithrix jacchus) is a recently developed nonhuman primate model of multiple sclerosis. Here, Bert 't Hart and colleagues compare this model to EAE in rhesus monkeys, highlighting autoimmune mechanisms in CNS inflammation and demyelination, including the role of major histocompatibility complex restriction and preclinical evaluation of innovative immunotherapies.
't Hart
B A
BA
Dept of Immunobiology, Biomedical Primate Research Centre (BPRC), PO Box 3306, 2280 GH Rijswijk, The Netherlands. hart@bprc.nl
van Meurs
M
M
Brok
H P
HP
Massacesi
L
L
Bauer
J
J
Boon
L
L
Bontrop
R E
RE
Laman
J D
JD
D000208:Acute Disease; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000276:immunology*; D019013:CD40 Antigens / Q000276:immunology; D002144:Callithrix / Q000276:immunology*; D002427:Cebidae; D002520:Cercopithecidae; D002678:Chimera; D003711:Demyelinating Diseases; D003888:Desensitization, Immunologic; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D005802:Genes, MHC Class II; D006649:Histocompatibility Antigens / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy; D016899:Interferon-beta / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012377:Rodentia; D020889:Rolipram / Q000627:therapeutic use; D013045:Species Specificity; D014427:Twins
D000911:Antibodies, Monoclonal; D019013:CD40 Antigens; D006649:Histocompatibility Antigens; D007166:Immunosuppressive Agents; D011948:Receptors, Antigen, T-Cell; D016899:Interferon-beta; D020889:Rolipram