title: Effect of ispaghula husk on the faecal output of bile acids in healthy volunteers.
abstract: Faecal bile acids are associated with both colorectal cancer and serum cholesterol levels. We investigate whether dosing with ispaghula husk affects the faecal bile acid weights and concentrations in healthy adults. Sixteen healthy volunteers consumed 7.0 g/day ispaghula husk, containing 5.88 g/day Englyst-determinable dietary fibre, for the middle 8 weeks of a 12-week period. Stool samples were collected, analysed for faecal bile acids and their form and dry weight determined. Correlations between the faecal bile acids, the stool parameters and the dietary intake were tested. Ispaghula husk treatment significantly lowers faecal lithocholic and isolithocholic acids and the weighted ratio of lithocholic acids to deoxycholic acid. These effects revert towards their initial states at the end of the treatment period. These changes in the faecal bile acid profiles indicate a reduction in the hydrophobicity of the bile acids in the enterohepatic circulation.
authors.affiliation: School of Applied Science, South Bank University, Borough Road, London, UK. chaplimf@sbu.ac.uk
authors.forename: M F
authors.initials: MF
authors.lastname: Chaplin
authors.forename: S
authors.initials: S
authors.lastname: Chaudhury
authors.forename: P W
authors.initials: PW
authors.lastname: Dettmar
authors.forename: J
authors.initials: J
authors.lastname: Sykes
authors.forename: A D
authors.initials: AD
authors.lastname: Shaw
authors.forename: G J
authors.initials: GJ
authors.lastname: Davies
mesh_terms: D000328:Adult; D001647:Bile Acids and Salts / Q000032:analysis / Q000378:metabolism*; D002400:Cathartics / Q000494:pharmacology*; D003672:Defecation / Q000187:drug effects; D004043:Dietary Fiber / Q000494:pharmacology*; D004435:Eating; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D008297:Male; D011620:Psyllium / Q000494:pharmacology*
chemical_list: D001647:Bile Acids and Salts; D002400:Cathartics; D004043:Dietary Fiber; D011620:Psyllium