title: Decreased trabecular bone mineral density in newly diagnosed inflammatory bowel disease patients in Korea.
abstract: BACKGROUND
  Decreased bone mineral density (BMD) is common in Western patients with inflammatory bowel disease (IBD). However, BMD has never been studied in Asia where the demographic and socio-economic status are different from the West. The aim of this study was to investigate the prevalence and mechanisms of osteopenia in newly diagnosed Korean patients with IBD.
  
  
  METHODS
  We studied 14 patients with Crohn's disease (CD) and 25 patients with ulcerative colitis (UC), all of whom had never been treated with corticosteroids. Bone mineral density was measured in the lumbar spine and the femoral neck by dual energy X-ray absorptiometry. Biochemical parameters including serum osteocalcin, parathyroid hormone, plasma inactive and active vitamin D, and urinary deoxypyridinoline were measured.
  
  
  RESULTS
  The BMD Z score at the lumbar spine was lower both in CD and in UC patients, but there was no significant difference between the two groups. There was no significant difference in nutritional status or biochemical parameters of bone metabolism between patients with a normal BMD and those with a decreased BMD.
  
  
  CONCLUSIONS
  Low BMD at the lumbar spine is common in newly diagnosed Korean patients with IBD, a result which is similar to Western studies. The mechanism for low bone mass remains undetermined; however, nutritional status and hormonal parameters of bone metabolism, and ethnic differences are not likely to be an important factor in the pathogenesis of this bone loss.
authors.affiliation: Department of Internal Medicine, Kyung Hee University College of Medicine, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: S K
authors.initials: SK
authors.lastname: Yang
authors.forename: W H
authors.initials: WH
authors.lastname: Kim
authors.forename: Y S
authors.initials: YS
authors.lastname: Joo
authors.forename: S H
authors.initials: SH
authors.lastname: Dong
authors.forename: B H
authors.initials: BH
authors.lastname: Kim
authors.forename: J I
authors.initials: JI
authors.lastname: Lee
authors.forename: Y W
authors.initials: YW
authors.lastname: Chang
authors.forename: R
authors.initials: R
authors.lastname: Chang
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D007723:Korea; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D015995:Prevalence; D012959:Socioeconomic Factors