Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics.
Daly
J W
JW
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Garraffo
H M
HM
Spande
T F
TF
Decker
M W
MW
Sullivan
J P
JP
Williams
M
M
D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D015195:Drug Design; D006801:Humans; D018722:Nicotinic Agonists / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D011898:Ranidae; D012867:Skin / Q000737:chemistry*
D000470:Alkaloids; D018712:Analgesics, Non-Narcotic; D019086:Bridged Bicyclo Compounds, Heterocyclic; D018722:Nicotinic Agonists; D011725:Pyridines; C082748:epibatidine