title: Growth hormone secreting adenoma with unusual extension: coexisting pituitary cyst and its clinical significance.
abstract: A 58 year old man showed acromegalic features. The serum growth hormone (GH) level was 7.3 ng/ml and SMC (somatomedin-C) 637 U/ml. Triple stimulation test showed abnormal response compatible with a GH secreting tumour. The conventional enhanced MRI revealed a less enhanced hemisphere-shaped lesion at the right corner of the sella turcica. In addition, dynamic MRI demonstrated an elongated lesion extending to the left beyond the midline. The patient underwent transsphenoidal surgery. Besides the soft and suckable tumour at the right corner, we entered into a small cavity loosely filled with the tumour, which was subsequently also removed. The operative finding corresponded to the lesion shown in dynamic MRI. Postoperative GH and SMC levels became 2.3 ng/ml and 326 U/ml respectively. Incidental pituitary cystic lesions in autopsied cases have been reported to be 6-33%. This case had a GH secreting adenoma with coexisting pituitary cyst. The coexisting pituitary cyst supposedly influenced the unusual shape and extension of the pituitary adenoma. Coexistence of such lesion should be kept in mind for microadenoma on neuroradiological evaluation and on intraoperative inspection surrounding the tumour.
authors.affiliation: Department of Neurological Surgery, Chiba University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Saeki
authors.forename: S
authors.initials: S
authors.lastname: Sunada
authors.forename: H
authors.initials: H
authors.lastname: Tokunaga
authors.forename: S
authors.initials: S
authors.lastname: Hoshi
authors.forename: K
authors.initials: K
authors.lastname: Sunami
authors.forename: T
authors.initials: T
authors.lastname: Terano
authors.forename: A
authors.initials: A
authors.lastname: Yamaura
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000379:methods; D010900:Pituitary Diseases / Q000150:complications* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D013194:Staining and Labeling / Q000379:methods; D016896:Treatment Outcome
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone