title: FKF1, a clock-controlled gene that regulates the transition to flowering in Arabidopsis.
abstract: Plant reproduction requires precise control of flowering in response to environmental cues. We isolated a late-flowering Arabidopsis mutant, fkf1, that is rescued by vemalization or gibberellin treatment. We positionally cloned FKF1, which encodes a novel protein with a PAS domain similar to the flavin-binding region of certain photoreceptors, an F box characteristic of proteins that direct ubiquitin-mediated degradation, and six kelch repeats predicted to fold into a beta propeller. FKF1 mRNA levels oscillate with a circadian rhythm, and deletion of FKF1 alters the waveform of rhythmic expression of two clock-controlled genes, implicating FKF1 in modulating the Arabidopsis circadian clock.
authors.affiliation: Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Nelson
authors.forename: J
authors.initials: J
authors.lastname: Lasswell
authors.forename: L E
authors.initials: LE
authors.lastname: Rogg
authors.forename: M A
authors.initials: MA
authors.lastname: Cohen
authors.forename: B
authors.initials: B
authors.lastname: Bartel
mesh_terms: D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics / Q000502:physiology; D029681:Arabidopsis Proteins; D001483:Base Sequence; D001683:Biological Clocks / Q000502:physiology*; D002940:Circadian Rhythm; D018744:DNA, Plant; D017343:Genes, Plant; D018546:Hypocotyl; D008027:Light; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger
chemical_list: D029681:Arabidopsis Proteins; D018744:DNA, Plant; C410504:FKF1 protein, Arabidopsis; D010940:Plant Proteins; D012333:RNA, Messenger