title: Antibiotics for gram-positive bacterial infections. Vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid.
abstract: Vancomycin is a safe, effective antibiotic for a variety of serious gram-positive infections. Because of emerging resistance in enterococci and staphylococci and the emerging threat of spread of vancomycin-resistant genes to other gram-positive organisms, judicious use of vancomycin should be promoted. Quinupristin/dalfopristin, a streptogramin antibiotic, and linezolid, an oxazolidinone, show promise against some strains of gram-positive bacteria that are resistant to vancomycin.
authors.affiliation: Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.
authors.forename: T S
authors.initials: TS
authors.lastname: Lundstrom
authors.forename: J D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000081:Acetamides / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D006094:Gram-Positive Bacteria / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D006801:Humans; D000069349:Linezolid; D010080:Oxazoles / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D023303:Oxazolidinones; D017334:Teicoplanin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D014640:Vancomycin / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D014769:Virginiamycin / Q000031:analogs & derivatives / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D010080:Oxazoles; D023303:Oxazolidinones; D014769:Virginiamycin; C113825:quinupristin; D017334:Teicoplanin; D014640:Vancomycin; D000069349:Linezolid; C113826:dalfopristin