Recent applications of polymer-supported reagents and scavengers in combinatorial, parallel, or multistep synthesis.
There has been a wealth of recent reports concerning support-bound reagents and scavengers in the solution-phase synthesis of compound libraries and natural products. Important advances in 1999 include the continued development and use of novel reagents for heterocycle synthesis, the increased use of catch-and-release purification, and the development of increasingly sophisticated techniques to allow sequestering of many types of impurities from desired compounds. These techniques have all been combined to enable the complicated multistep synthesis of natural products and of libraries of novel drug-like molecules, without conventional purification.
Thompson
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The DuPont Pharmaceuticals Company, E500 1803-B Experimental Station, Wilmington, DE 19880-0500, USA. drew.a.thompson@dupontpharma.com
D020650:Combinatorial Chemistry Techniques; D016166:Free Radical Scavengers / Q000737:chemistry*; D007202:Indicators and Reagents; D011108:Polymers / Q000737:chemistry*
D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D011108:Polymers