Primary testicular seminoma in a patient with a history of extragonadal non-seminomatous germ cell carcinoma.
Extragonadal germ cell carcinoma represents between 3% and 5% of all germ cell carcinomas. A metachronous primary germ cell carcinoma is exceedingly rare in these patients. We report the eighth case, which occurred in a 29-year-old man who presented with testicular seminoma 7 years after his initial presentation with extragonadal non-seminomatous germ cell carcinoma. The seven other patients also presented with extragonadal non-seminomatous germ cell carcinoma, followed subsequently by testicular seminoma in 6 patients and non-seminomatous germ cell carcinoma in the seventh. The mean time to presentation was 8 years. Although rare, this case emphasizes the need for long-term surveillance, including testicular evaluation of patients with a history of extragonadal germ cell carcinoma.
Allaway
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Department of Urology, West Virginia University, Morgantown, West Virginia 26506, USA.
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D000328:Adult; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal; D016609:Neoplasms, Second Primary; D012186:Retroperitoneal Neoplasms; D018239:Seminoma; D013736:Testicular Neoplasms