title: Biosynthesis of isoprenoids in Escherichia coli: stereochemistry of the reaction catalyzed by farnesyl diphosphate synthase.
abstract: [formula: see text] Farnesyl diphosphate (FPP) synthase from Escherichia coli catalyzes the condensation of isopentenyl diphosphate (IPP) and geranyl diphosphate (GPP) with selective removal of the pro-R hydrogen at C2 of IPP, the same stereochemistry observed for the pig liver, yeast, and avian enzymes.
authors.affiliation: Department of Chemistry, University of Utah, Salt Lake City 84112, USA.
authors.forename: A E
authors.initials: AE
authors.lastname: Leyes
authors.forename: J A
authors.initials: JA
authors.lastname: Baker
authors.forename: C D
authors.initials: CD
authors.lastname: Poulter
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000378:metabolism*; D000818:Animals; D002384:Catalysis; D002645:Chickens; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D051228:Geranyltranstransferase; D045782:Hemiterpenes; D009943:Organophosphorus Compounds / Q000378:metabolism*; D013237:Stereoisomerism; D013552:Swine
chemical_list: D045782:Hemiterpenes; D009943:Organophosphorus Compounds; C004809:isopentenyl pyrophosphate; C043060:3,3-dimethylallyl pyrophosphate; D019883:Alkyl and Aryl Transferases; D051228:Geranyltranstransferase