Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease.
Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apa1 A (P=.03; Fisher's exact test), TaqI t (P=.04), and the At VDR haplotype (P=.04), and they displayed a decreased prevalence of FokI f (P=.04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P=.001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.
Gelder
C M
CM
Dept. of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XX, Wales, United Kingdom. GelderCM@cf.ac.uk
Hart
K W
KW
Williams
O M
OM
Lyons
E
E
Welsh
K I
KI
Campbell
I A
IA
Marshall
S E
SE
D004198:Disease Susceptibility; D006239:Haplotypes; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D009164:Mycobacterium Infections / Q000209:etiology*; D009894:Opportunistic Infections / Q000209:etiology*; D010641:Phenotype; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol