Some allylic substituent effects in ring-closing metathesis reactions: allylic alcohol activation.
[formula: see text] Dienes 2a-e were used to study allylic substituent effects in the ring-closing metathesis reaction (RCM). Both the steric and electronic character of the allylic substituents were found to influence alkene reactivities. Free allylic hydroxyl groups exert a large activating effect on the RCM reaction rates.
Hoye
T R
TR
Department of Chemistry, University of Minnesota, Minneapolis 55455, USA. hoye@chem.umn.edu
Zhao
H
H
D007700:Kinetics; D020005:Propanols / Q000737:chemistry*
D020005:Propanols; C006463:allyl alcohol