Preparation of new chiral borane-protected P,N-ferrocenyl ligands via a methoxy directed ortho-lithiation.
We have shown that the readily prepared (ferrocenyl)benzylic methyl ethers of type 1 can be ortho-metalated with tert-BuLi with high diastereoselectivity. This reaction has been used to prepare new borane-protected P,N-substituted ferrocenes of type 2 in high diastereomeric and enantiomeric purity. The chiral heterocyclic aminophosphines 2 may be of interest as chelating ligands for asymmetric metal catalysis.
Lotz
M
M
Department of Chemistry, University of Munich, Munich, Germany.
Ireland
T
T
Tappe
K
K
Knochel
P
P