title: [Felty's syndrome].
abstract: BACKGROUND
  Felty's syndrome is a complication of rheumatoid arthritis whereby patients develop neutropenia of varying severity and splenomegaly. The major sources of morbidity and mortality are recurrent local and systemic infections, although some patients remain asymptomatic.
  
  
  METHODS
  In this paper two patients with Felty's syndrome are presented.
  
  
  RESULTS
  One patient had recurrent infections. Clinical manifestations, laboratory features and different modalities of treatment are reviewed.
  
  
  CONCLUSIONS
  Splenectomy has long been standard therapy, but disease modifying antirheumatic drugs (such as gold salts and methotrexate) and colony stimulating factors should also be considered in Felty's neutropenia complicated with infections.
authors.affiliation: Senter for revmatiske sykdommer Rikshospitalet, Oslo.
authors.forename: V
authors.initials: V
authors.lastname: Lilleby
authors.forename: J T
authors.initials: JT
authors.lastname: Gran
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D003115:Colony-Stimulating Factors / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005258:Felty Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013156:Splenectomy
chemical_list: D018501:Antirheumatic Agents; D003115:Colony-Stimulating Factors