title: Resectional treatment for thyroid cancer with tracheal invasion: a long-term follow-up study.
abstract: OBJECTIVE
  Transmural invasion of the trachea by well-differentiated thyroid carcinomas is a locally advanced disease condition. It frequently causes deaths owing to airway obstruction. We hypothesized that resection of the invaded trachea followed by primary anastomosis provides the opportunity for cure.
  
  
  METHODS
  A retrospective review study of medical records.
  
  
  METHODS
  The surgical department of a tertiary referral center.
  
  
  METHODS
  Eight patients with well-differentiated thyroid carcinomas, complicated with tracheal invasion resulting in bleeding and airway obstruction, operated on by tracheal resection and immediate anastomosis, were included.
  
  
  METHODS
  All patients received total thyroidectomy and neck lymph node dissection as well as segmental tracheal resection followed by primary reconstruction. Postoperative radioactive sodium iodine I 131 treatment and suppression therapy with thyroxine were applied to all of them.
  
  
  METHODS
  Postoperative follow-up of serum levels of human thyroglobulin and abnormal radioactive iodine 131I from whole body scan.
  
  
  RESULTS
  Seven patients are alive. Of these patients, 5 had no evidence of disease: (3 had no evidence of cancer for more than 10 years' follow-up), 2 had regional lymph node metastasis, and 1 had lung metastases. The remaining patient had anastomotic site recurrence with airway obstruction and needed tracheostomy to relieve stridor. She was lost to follow-up 39 months after undergoing the initial operation.
  
  
  CONCLUSIONS
  Patients with mucosal invasion of the trachea by well-differentiated thyroid carcinomas should be treated by surgical resection followed by primary reconstruction when technically feasible. This facilitates postoperative care, and it is possible to achieve long-term survival with improvement of the quality of life and possible cures.
authors.affiliation: Department of Emergency Medicine, Veterans General Hospital-Taipei, and National Yang-Ming University, Taiwan.
authors.forename: C C
authors.initials: CC
authors.lastname: Yang
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
authors.forename: L S
authors.initials: LS
authors.lastname: Wang
authors.forename: B S
authors.initials: BS
authors.lastname: Huang
authors.forename: W H
authors.initials: WH
authors.lastname: Hsu
authors.forename: M H
authors.initials: MH
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000209:etiology; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy; D013997:Time Factors; D014132:Trachea / Q000601:surgery*; D014134:Tracheal Neoplasms / Q000150:complications / Q000473:pathology*