The influence of ethnicity and antidepressant pharmacogenetics in the treatment of depression.
Antidepressant disposition can be influenced by a variety of CYP isozymes and their effects in the treatment of depression are reviewed. The CYP isozymes 2D6, 3A4, 1A2 and 2C are discussed in regard to antidepressant drug pharmacokinetics, clinical relevance and variability in activity for each isozyme. Polymorphism has been identified with CYP 2D6 and 2C19. Disposition of antidepressants which are substrates of these two isozymes can also be influenced and contributes towards the wide interpatient and interethnic variability found with these drugs. Antidepressants (especially SSRIs) can be CYP isozyme inhibitors and produce significant drug-drug interactions.
Jann
M W
MW
Department of Pharmacy Practice and Pharmaceutical Sciences, Mercer University, Southern School of Pharmacy, Atlanta, GA 30341-4155, USA.
Cohen
L J
LJ
D000928:Antidepressive Agents / Q000378:metabolism / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D003866:Depressive Disorder / Q000188:drug therapy* / Q000208:ethnology / Q000235:genetics*; D004347:Drug Interactions; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D010597:Pharmacogenetics
D000928:Antidepressive Agents; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System