title: Sex-related differences in the muscarinic acetylcholinergic receptor in the healthy human brain--a positron emission tomography study.
abstract: We evaluated the sex-related differences in the decline of the cerebral muscarinic acetylcholinergic receptor (mACh-R) due to aging by using 11C-N-methyl-4-piperidyl benzilate (11C-NMPB) and positron emission tomography (PET). The subjects consisted of 37 (20 males and 17 females) healthy volunteers. The 11C-NMPB uptake was evaluated by the ratio method (regional 11C-NMPB uptake/Cerebellar 11C-NMPB uptake; rNMPB ratio). The correlation between sex, aging, and the rNMPB ratio in normal aging was evaluated by a multiple regression analysis. The rNMPB ratio was higher in females than in males throughout the entire cerebral region (p < 0.01-p < 0.0001) and the rNMPB ratio might thus possibly decline with age more rapidly in females. Our study therefore revealed the existence of sex-related differences in the cerebral mACh-R.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Kuwabara
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: T
authors.initials: T
authors.lastname: Fukumura
authors.forename: A
authors.initials: A
authors.lastname: Ichimiya
authors.forename: M
authors.initials: M
authors.lastname: Takita
authors.forename: K
authors.initials: K
authors.lastname: Ogomori
authors.forename: Y
authors.initials: Y
authors.lastname: Ichiya
authors.forename: K
authors.initials: K
authors.lastname: Masuda
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism; D001561:Benzilates; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D008024:Ligands; D008297:Male; D008875:Middle Aged; D010880:Piperidines; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012727:Sex Characteristics; D014055:Tomography, Emission-Computed
chemical_list: D001561:Benzilates; D002250:Carbon Radioisotopes; D008024:Ligands; D010880:Piperidines; D011976:Receptors, Muscarinic; C020407:enpiperate