title: Bromoacetophenone-based photonucleases: photoinduced cleavage of DNA by 4'-bromoacetophenone-pyrrolecarboxamide conjugates.
abstract: [formula: see text] 4'-Bromoacetophenone derivatives which upon excitation can generate monophenyl radicals capable of hydrogen atom abstraction were investigated as photoinducible DNA cleaving agents. Pyrrolecarboxamide-conjugated 4'-bromoacetophenones were synthesized, and their DNA cleaving activities and sequence selectivities were determined.
authors.affiliation: Department of Chemistry, Stanford University, California 94305, USA. wenderp@leland.standford.edu
authors.forename: P A
authors.initials: PA
authors.lastname: Wender
authors.forename: R
authors.initials: R
authors.lastname: Jeon
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001345:Autoradiography; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D004591:Electrophoresis, Polyacrylamide Gel; D016166:Free Radical Scavengers / Q000737:chemistry; D008027:Light; D010777:Photochemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C410763:4'-bromoacetophenone-pyrrolecarboxamine; D000098:Acetophenones; D016166:Free Radical Scavengers; D011758:Pyrroles; C013190:phenacyl bromide; D004247:DNA