title: Synthesis and evaluation of a new series of 17alpha-[(123)I]iodovinyl estradiols.
abstract: A series of 17alpha-substituted estradiols was synthesized in which the stereochemical characteristics of carbons 20 and 21 were modified. It was found that the (Z)-isomer demonstrated more favorable receptor binding affinity than the corresponding (E)-isomer.
authors.affiliation: University of Tennessee Biomedical Imaging Center, Knoxville, Tennessee 37996-1600, USA. kabalka@utk.edu
authors.forename: G W
authors.initials: GW
authors.lastname: Kabalka
authors.forename: T M
authors.initials: TM
authors.lastname: Shoup
authors.forename: G B
authors.initials: GB
authors.lastname: Daniel
authors.forename: M M
authors.initials: MM
authors.lastname: Goodman
mesh_terms: D000818:Animals; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D005260:Female; D007275:Injections, Intravenous; D007457:Iodine Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes; D008024:Ligands; D019275:Radiopharmaceuticals; D011960:Receptors, Estrogen; D004958:Estradiol