The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose.
The mechanical properties of compacts of unlubricated microcrystalline cellulose and silicified microcrystalline cellulose were evaluated using the diametric tensile test. The results suggested that, under comparable testing conditions, compacts of silicified microcrystalline cellulose exhibited greater strength than those of microcrystalline cellulose. In addition to enhanced strength, silicified microcrystalline cellulose compacts exhibited greater stiffness and required considerably more energy for tensile failure to occur. Comparison of the data with that obtained for a dry blend of silicon dioxide/microcrystalline cellulose suggested that the functionality benefits of silicification were not due to a simple composite material model.
Edge
S
S
Department of Pharmacy and Pharmacology, University of Bath, UK.
Steele
D F
DF
Chen
A
A
Tobyn
M J
MJ
Staniforth
J N
JN
D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005079:Excipients / Q000737:chemistry*; D006244:Hardness; D008153:Lubrication; D011208:Powders; D012822:Silicon Dioxide / Q000737:chemistry*; D013718:Tensile Strength
D005079:Excipients; D011208:Powders; D012822:Silicon Dioxide; D002482:Cellulose; C109691:microcrystalline cellulose