title: A rationally designed anticancer drug targeting a unique binding cavity of tubulin.
abstract: A novel mono-THF containing synthetic anticancer drug (WHI-261) was designed for targeting a previously unrecognized unique narrow binding cavity on the surface of tubulin. The anti-cancer activity of WHI-261 was confirmed using MTT assays. The structure-based design, synthesis, and biological activity of WHI-261 are reported.
authors.affiliation: Drug Discovery Program and Parker Hughes Cancer Center, Parker Hughes Institute, St. Paul, MN 55113, USA. fatih_uckun@mercury.ih.org
authors.forename: F M
authors.initials: FM
authors.lastname: Uckun
authors.forename: C
authors.initials: C
authors.lastname: Mao
authors.forename: A O
authors.initials: AO
authors.lastname: Vassilev
authors.forename: C S
authors.initials: CS
authors.lastname: Navara
authors.forename: R K
authors.initials: RK
authors.lastname: Narla
authors.forename: S T
authors.initials: ST
authors.lastname: Jan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D005663:Furans / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005233:Fatty Alcohols; D005663:Furans; D014404:Tubulin; C413724:WHI 261; C018674:tetrahydrofuran