title: Rapid Solubility Determination Using Vapor-Phase Osmometry.
abstract: Because of the need for resource-sparing assays of the solubility of new drug candidates, we sought to develop and validate a rapid method for determining the solubility of nonvolatile pharmaceutical solids in water. Vapor-phase osmometry was used to determine the concentration of drugs in saturated solutions prepared by a rapid ultrasound-mediated dissolution protocol. The osmolality of saturated solutions as measured by the vapor-phase osmometer is an excellent predictor of the solubility of pharmaceutical solids in water. Each osmolality measurement requires less than 10 µl of saturated solution and takes less than 2 min to complete. For small-molecule drugs with solubilities greater than 10 g/kg, osmometry may prove to be a rapid and accurate method for determining the water solubilities of drugs.
authors.affiliation: Department of Pharmaceutics, State University of New York at Buffalo, Buffalo, NY.
authors.initials: HH
authors.lastname: Parikh
authors.initials: V
authors.lastname: Balasubramanian
authors.initials: WL
authors.lastname: Chu
authors.initials: ME
authors.lastname: Morris
authors.initials: M
authors.lastname: Ramanathan