Molecular motors and their role in membrane traffic.
Recent investigations support a role for the vesicle motor proteins (kinesin, cytoplasmic dynein, and myosin) in numerous membrane trafficking events including endocytosis and transcytosis. Kinesin and cytoplasmic dynein are responsible for movement of membrane vesicles along cellular microtubules to and from cellular membrane compartments, while certain members of the myosin family also appear to drive membrane vesicles along actin filaments to and from membrane compartments. In this review, our current understanding of the role of these vesicle motors in membrane trafficking is highlighted. Future areas of interest which may be able to make use of these vesicle motors as potential targets for drug delivery are also discussed.
Hamm-Alvarez
SF
Department of Pharmaceutical Sciences, USC School of Pharmacy, 1985 Zonal Ave., Los Angeles, CA 90033, USA