title: Evolution of DNA and RNA as catalysts for chemical reactions.
abstract: In vitro selection from combinatorial nucleic acid libraries has provided new RNA and DNA molecules that have catalytic properties. Catalyzed reactions now go far beyond self-modifying reactions of nucleic acid molecules. The future application of in vitro selected RNA and DNA catalysts in bioorganic synthesis appears promising.
authors.affiliation: Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Institute of Chemistry, Berlin, D-14195, Germany. jaschke@chemie.fu-berlin.de
authors.forename: A
authors.initials: A
authors.lastname: Jäschke
authors.forename: B
authors.initials: B
authors.lastname: Seelig
mesh_terms: D000215:Acylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry*; D019020:Directed Molecular Evolution; D006868:Hydrolysis; D009690:Nucleic Acid Conformation; D010766:Phosphorylation; D012313:RNA / Q000737:chemistry*
chemical_list: D012313:RNA; D004247:DNA