Interaction of antimalarial agent artemisinin with cyclodextrins.
To obtain an effective solution of the poorly water soluble antimalarial agent artemisinin, the use of several kinds of cyclodextrins (CDs) as solubilizers was examined. The following CDs were used in this study: alpha-CD, beta-CD, gamma-CD as parent CDs, 2-hydroxypropyl-beta-CD (HP-beta-CD), sulfobutyl ether beta-CD (SBE7-beta-CD), heptakis (2,6-di-O-methyl)-beta-CD (DM-beta-CD), 2,3,6-partially methylated-beta-CD (PM-beta-CD) as modified CDs, and glucosyl-beta-CD (G1-beta-CD), and maltosyl-beta-CD (G2-beta-CD) as branched CDs. The solubility curves of artemisinin with CDs can all be classified as type AL. The apparent stability constants for artemisinin-parent CD complexes increased in the order of alpha- < gamma- < or = beta-CD. The constants for artemisinin-beta-CD derivative (and beta-CD) complexes increased in the order of G2-beta-CD approximately equal to G1-beta-CD approximately equal to PM-beta-CD approximately equal to beta-CD < HP-beta-CD < SBE7-beta-CD < DM-beta-CD. These results suggest that the addition of CDs enables the solubilization of artemisinin.
Usuda
M
M
Department of Physical Chemistry, Hoshi University, Tokyo, Japan.
Endo
T
T
Nagase
H
H
Tomono
K
K
Ueda
H
H
D000962:Antimalarials / Q000737:chemistry*; D037621:Artemisinins; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004347:Drug Interactions; D004355:Drug Stability; D006868:Hydrolysis; D011108:Polymers / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
D000962:Antimalarials; D037621:Artemisinins; D003505:Cyclodextrins; D011108:Polymers; D012717:Sesquiterpenes; D014867:Water; C031327:artemisinin