title: Orthodontic tooth movement in the prednisolone-treated rat.
abstract: Adverse effects of corticosteroids on bone metabolism raise concerns as to whether steroid treatment may influence orthodontic movement. This study examined the effect of prednisolone on orthodontic movement using an established rat model. The corticosteroid treated group (N = 6) was administered prednisolone (1 mg/kg) daily, for a 12-day induction period; the control group (N = 6) received equivalent volumes of saline. On day 12, an orthodontic appliance was placed which exerted 30 g of mesial force to the maxillary first molar. Animals were sacrificed on day 24 and tooth movement was measured. Sagittal sections of the molars were stained with haematoxylin and eosin, and for tartrate-resistant acid phosphatase (TRAP) activity. While there were no significant differences in the magnitude of tooth movement between the 2 groups, steroid-treated rats displayed significantly less root resorption on the compression side and fewer TRAP-positive cells within the PDL space on the same side. This suggests steroid treatment suppressed clastic activity.
authors.affiliation: School of Dentistry, University of Queensland, Brisbane, Australia.
authors.forename: C K
authors.initials: CK
authors.lastname: Ong
authors.forename: L J
authors.initials: LJ
authors.lastname: Walsh
authors.forename: D
authors.initials: D
authors.lastname: Harbrow
authors.forename: A A
authors.initials: AA
authors.lastname: Taverne
authors.forename: A L
authors.initials: AL
authors.lastname: Symons
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D016301:Alveolar Bone Loss / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016723:Bone Remodeling / Q000187:drug effects*; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008437:Maxilla; D009967:Orthodontic Appliances; D010010:Osteoclasts / Q000187:drug effects; D010513:Periodontal Ligament / Q000378:metabolism; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012391:Root Resorption / Q000378:metabolism / Q000517:prevention & control*; D000071681:Tartrate-Resistant Acid Phosphatase; D014087:Tooth Movement Techniques
chemical_list: D000893:Anti-Inflammatory Agents; D007527:Isoenzymes; D011239:Prednisolone; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase