[Effect of moxonidine monotherapy and in combination with melatonin on hemodynamic parameters in patients with arterial hypertension].
Fifty patients (mean age 53.8 +/- 3.45) with arterial hypertension were examined. They were divided into 2 randomized groups, 25 patients each. One group received moxonidine, 40 mg, alone in the morning, the other had moxonidine in the same dose in combination with melatonin, 3 mg, overnight. The treatment lasted 14 days. Monitoring of blood pressure (BP), heart rate (HR), EchoCG was made before and after treatment. The studies indicated that moxonidine had a pronounced antihypertensive effect by slightly lowering BP overnight and that the chronostructure of BP and HR rhythms was impaired. Addition of melatonin to the moxonidine therapy with greater antihypertensive effects made the chronostructure of circadian BP and HR rhythms normal.
Zaslavskaia
R M
RM
Komarov
F I
FI
Shakirova
A N
AN
Teĭblium
M M
MM
Akhmetov
K Zh
KZh
D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007093:Imidazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008550:Melatonin / Q000494:pharmacology* / Q000627:therapeutic use*; D008875:Middle Aged
D000959:Antihypertensive Agents; D007093:Imidazoles; C043482:moxonidine; D008550:Melatonin