Optical rotation per refractive index unit, or enantiomeric (e) factor, for screening enantioselective catalysts through asymmetric activation or carbohydrates.
A super high-throughput screening (SHTS) system can be constructed by combining high-performance liquid chromatography (HPLC), optical rotation (OR), and refractive index unit (RIU) to determine not only the enantioselectivity of the addition of diethylzinc to an aliphatic aldehyde catalyzed by a binaphthol-zinc complex through asymmetric activation with chiral Schiff bases, but also the enantiopurity of a carbohydrate. The enantiomeric (e) factor, which we define here as optical rotation per refractive index unit, is linearly related to the percent enantiomeric excess (%ee) and is independent of concentration.
Angelaud
R
R
Tokyo Institute of Technology, Tokyo, Japan.
Matsumoto
Y
Y
Korenaga
T
T
Kudo
K
K
Senda
M
M
Mikami
K
K
D000097:Acetonitriles / Q000737:chemistry; D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D002621:Chemistry / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D008956:Models, Chemical; D000442:Octanols / Q000737:chemistry*; D012031:Refractometry
D000097:Acetonitriles; D002241:Carbohydrates; D000442:Octanols; C032159:acetonitrile