Epicalyxin F and calyxin I: two novel antiproliferative diarylheptanoids from the seeds of Alpinia blepharocalyx.
[formula: see text] Epicalyxin F (1) and calyxin I (2), two novel diarylheptanoids, were isolated from a residual fraction of an EtOH extract of Alpinia blepharocalyx. Calyxin I (2) represented a new carbon skeleton, and epicalyxin F (1) possessed potent antiproliferative activity toward HT-1080 fibrosarcoma and colon 26-L5 carcinoma with ED50 values of 1.71 and 0.89 microM, respectively.
Gewali
M B
MB
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan.
Tezuka
Y
Y
Banskota
A H
AH
Ali
M S
MS
Saiki
I
I
Dong
H
H
Kadota
S
S
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D002681:China; D036381:Diarylheptanoids; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D011714:Pyrans / Q000302:isolation & purification*; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D036381:Diarylheptanoids; D004365:Drugs, Chinese Herbal; D011714:Pyrans; C410688:calyxin I; C410689:epicalyxin F