Neurotrophins: more to NGF than just survival.
NGF's role in neuronal survival has tended to mask other potential functions. But now the generation of mice lacking both Bax - required for the death of NGF-deprived neurons - and NGF or its receptor has shown that NGF plays a key role in establishing cutaneous innervation and regulating neuropeptide expression.
Davies
A M
AM
Bute Medical Buildings, School of Biology, University of St. Andrews, St. Andrews, KY16 9TS, Scotland. md2@st-and.ac.uk.
D000818:Animals; D051379:Mice; D020932:Nerve Growth Factor / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein
C494827:Bax protein, mouse; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D020932:Nerve Growth Factor