Evolution of DNA and RNA as catalysts for chemical reactions.
In vitro selection from combinatorial nucleic acid libraries has provided new RNA and DNA molecules that have catalytic properties. Catalyzed reactions now go far beyond self-modifying reactions of nucleic acid molecules. The future application of in vitro selected RNA and DNA catalysts in bioorganic synthesis appears promising.
Jäschke
A
A
Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, Institute of Chemistry, Berlin, D-14195, Germany. jaschke@chemie.fu-berlin.de
Seelig
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B
D000215:Acylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry*; D019020:Directed Molecular Evolution; D006868:Hydrolysis; D009690:Nucleic Acid Conformation; D010766:Phosphorylation; D012313:RNA / Q000737:chemistry*
D012313:RNA; D004247:DNA