Yeasts and fluconazole susceptibility in the Philippines.
Identification and fluconazole susceptibility of 579 yeasts isolated from patients in 16 medical centers throughout the Philippines in 1997-98 is reported. Speciation revealed the following distribution of yeasts (with percent occurrence): Candida albicans (49.6%); C. parapsilosis (17.2%); C. tropicalis (14.9%); C. glabrata (6.2%); C. pelliculosa (4.3%); C. krusei (2.4%); C. guilliermondii (1.9%); Trichosporon cutaneum (1.7%); Cryptococcus neoformans (0.9%); Candida famata (0.5%); C. lusitaniae (0.2%) and Saccharomyces cerevisiae (0.2%). Using an agar disk diffusion assay for fluconazole susceptibility it was determined that 94% of the isolates were susceptible, 5% dose-dependent susceptible and only 1% resistant. All isolates of C. albicans were susceptible (one being dose dependent sensitive) to fluconazole. The only yeasts resistant to fluconazole were: C. guillermondii (1 isolate), C. glabrata (3 isolates) and C. parapsilosis (1 isolate).
Bulmer
G S
GS
University of Santo Tomas School of Medicine & Surgery, Department of Laboratory Medicine, Manila, Philippines. Glenn@compass.com.ph
Marquez
M L
ML
Co-Barcelona
L
L
Fromtling
R A
RA
D000935:Antifungal Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*; D010679:Philippines; D015003:Yeasts / Q000187:drug effects* / Q000302:isolation & purification
D000935:Antifungal Agents; D015725:Fluconazole