Chlamydia pneumoniae and cardiovascular disease: an evolutionary perspective on infectious causation and antibiotic treatment.
Evolutionary considerations implicate infectious causation of atherosclerosis and help to resolve different risk factors as parts of an overall process of disease causation. An evolutionary approach also provides insight for the timing of research efforts to provide better control of pathogen evolution. In particular, evolutionary considerations emphasize the need to understand the transmissibility of Chlamydia pneumoniae from systemic infections in order to control the evolution of antibiotic resistance.
Ewald
P W
PW
Department of Biology, Amherst College, Amherst, MA 01002-5000, USA. pwewald@amherst.edu
Cochran
G M
GM
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000209:etiology* / Q000382:microbiology; D002690:Chlamydia Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000187:drug effects / Q000235:genetics*; D004352:Drug Resistance, Microbial; D019143:Evolution, Molecular; D020022:Genetic Predisposition to Disease; D006801:Humans
D000900:Anti-Bacterial Agents