title: Can retinoic acid ameliorate the physiologic and morphologic effects of elastase instillation in the rat?
authors.affiliation: Genentech, Inc, South San Francisco, CA 94080, USA.
authors.forename: J
authors.initials: J
authors.lastname: Tepper
authors.forename: J
authors.initials: J
authors.lastname: Pfeiffer
authors.forename: M
authors.initials: M
authors.lastname: Aldrich
authors.forename: D
authors.initials: D
authors.lastname: Tumas
authors.forename: J
authors.initials: J
authors.lastname: Kern
authors.forename: E
authors.initials: E
authors.lastname: Hoffman
authors.forename: G
authors.initials: G
authors.lastname: McLennan
authors.forename: D
authors.initials: D
authors.lastname: Hyde
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D007322:Instillation, Drug; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D010196:Pancreatic Elastase / Q000008:administration & dosage / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D014132:Trachea; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use*
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin; D010196:Pancreatic Elastase