title: The beneficial effects of calcium channel blockers on long-term kidney transplant survival are independent of blood-pressure reduction.
abstract: There is a growing body of evidence suggesting that calcium channel blockers (CCB) exert beneficial effects on kidney transplant survival. However, it is not completely understood if these agents act independently of blood-pressure reduction. In the present study, the 5-yr follow-up of 45 kidney transplant recipients receiving CCB during the 60-month follow-up period was compared to that of recipients with lower blood pressure and an antihypertensive treatment without CCB. During the whole follow-up, systolic (127.4 +/- 2.5 vs. 139.4 +/- 2.1 mmHg, p < 0.05) as well as diastolic blood pressure (78.8 +/- 1.1 vs. 84.8 +/- 1.8 mmHg, p < 0.05) was higher in the group receiving CCB. Moreover, in CCB-treated recipients, a significant (p < 0.05) higher increase in proteinuria was detected (from 759 +/- 120 to 1690 +/- 359 mg/24 h vs. 180 +/- 45 to 340 +/- 45 mg/24 h). Despite higher blood pressure and higher proteinuria, the increase in serum creatinine in the group of CCB-treated recipients was significantly lower (0.01 mg/dL/month) in comparison to that of the controls (0.02 mg/dL/month, p < 0.05). Moreover, the 5-yr transplant survival was significantly higher in CCB-treated recipients (62.3 vs. 31.8%, p < 0.05). The results of the present study further support the beneficial effects of CCB in kidney transplant recipients, which are independent of blood-pressure reduction.
authors.affiliation: Medizinische Poliklinik, Universität Münster, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Mehrens
authors.forename: S
authors.initials: S
authors.lastname: Thiele
authors.forename: B
authors.initials: B
authors.lastname: Suwelack
authors.forename: M
authors.initials: M
authors.lastname: Kempkes
authors.forename: H
authors.initials: H
authors.lastname: Hohage
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D016030:Kidney Transplantation; D009543:Nifedipine / Q000627:therapeutic use*; D011507:Proteinuria; D012189:Retrospective Studies
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D003404:Creatinine; D009543:Nifedipine