title: [Surgical reconstruction of fibrous dysplasia of bone in long-term follow-up].
abstract: OBJECTIVE
  To examine how different operative measures influence the surgical outcome in patients with fibrous dysplasia of bone.
  
  
  METHODS
  118 dysplastic fibrous lesions of bone were surgically treated and reviewed in 70 patients between 1983 to 1993 (eleven years) with a median follow-up of six and a half years. Surgery consisted of intralesional curettage in 93 and marginal en bloc resection in 25 lesions. Bony defects were reconstructed with autogenous iliac crest graft in 55 lesions, with autogenous fibula graft in 9, with homologous bone chips in 28, and 5 times with a homologous fibula graft from the bone bank. In 33 lesions the entire defect was filled with polymethylmethacrylate. Osteosynthesis was performed in 41 patients.
  
  
  RESULTS
  Recurrences requiring surgical revision were observed in 26 of 74 primary lesions (= 35% overall recurrence rate) at a mean 123.6 weeks postoperatively. The most frequent primary and recurrence location was the proximal femur (85% revision rate). 69% of all recurrences occurred under the age of 20. After intralesional curettage the reoperation rate was 32% and after marginal resection 8%. After reconstruction with autogenous iliac crest graft recurrence rate was 36%, after autogenous fibula graft 55%, after homologous bone chips 18%, after polymethylmethacrylate 9% and allograft fibula reconstruction showed no recurrences. A combined stable osteosynthesis bridging the fibrous osseous defect significantly reduced the revision rate to 3% (p = 0.01).
  
  
  CONCLUSIONS
  Intralesional curettage and reconstruction with autogenous iliac crest graft in fibrous dysplasia of bone leads to a high recurrence rate. Reconstruction with cortical grafts or bone chips from the bone bank, if necessary in combination with a durable osteosynthesis in mechanically demanding locations, or solely bone cement in mechanically less demanding areas, reduces the revision rate in patients with monoostotic and polyostotic fibrous dysplasia.
authors.affiliation: Klinik und Poliklinik für Allgemeine Orthopädie, Westfälischen Wilhelms-Universität Münster. Lindnen@uni-muenster.de
authors.forename: N
authors.initials: N
authors.lastname: Lindner
authors.forename: C
authors.initials: C
authors.lastname: Brinkschmidt
authors.forename: A
authors.initials: A
authors.lastname: Suddendorf
authors.forename: R
authors.initials: R
authors.lastname: Rödl
authors.forename: G
authors.initials: G
authors.lastname: Gosheger
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018786:Bone Substitutes; D016025:Bone Transplantation; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000000981:diagnostic imaging / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D011183:Postoperative Complications / Q000000981:diagnostic imaging* / Q000601:surgery; D011859:Radiography; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D018786:Bone Substitutes; D019904:Polymethyl Methacrylate