Improvement of visual acuity in patients suffering from diabetic retinopathy after membrane differential filtration: a pilot study.
BACKGROUND
Membrane differential filtration is an extracorporeal treatment procedure which eliminates high molecular weight proteins and lipids from the blood. This pilot study was initiated to investigate the short-term effects on blood rheology and visual function in patients suffering from diabetic retinopathy.


METHODS
Six patients with non-proliferative diabetic retinopathy, clinically significant macular edema (five patients, nine eyes) and inactive proliferative diabetic retinopathy (one patient, one eye) underwent a single treatment with a hollow fiber secondary plasma filter. The main parameter measured was visual acuity prior to and after treatment. Biochemical and rheological parameters (whole blood and plasma viscosity, and erythrocyte aggregation) were also measured. The mean follow-up was 25 (range 4-90) days after treatment.


RESULTS
The mean improvement of visual acuity was 1.4 lines (SD 0.8 lines, p = 0.002) 24 h after therapy. This remained stable during the follow-up period. The rheological measures were significantly lowered. A significant reduction of total protein, fibrinogen, IgG, IgM, IgA, alpha-2-macroglobulin, total cholesterol, LDL and HDL was found.


CONCLUSIONS
This study demonstrates the rheological impact of membrane differential filtration. It was shown that rheological changes correlated with clinical improvement in patients suffering from diabetic retinopathy with clinically significant macular edema.
Widder
R A
RA
Department of Ophthalmology, University of Cologne, Germany.
Brunner
R
R
Walter
P
P
Lüke
C
C
Bartz-Schmidt
K U
KU
Heimann
K
K
Borberg
H
H
D000368:Aged; D001809:Blood Viscosity; D003930:Diabetic Retinopathy / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D010974:Platelet Aggregation; D014792:Visual Acuity / Q000502:physiology*