Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection.
The relationship between human papillomavirus (HPV) DNA in the genital mucosa and serum IgG to HPV-16, -18, and -6 was studied in a cohort of 588 college women. Among women with incident HPV infections, 59.5%, 54.1%, and 68.8% seroconverted for HPV-16, -18, or -6, respectively, within 18 months of detecting the corresponding HPV DNA. Transient HPV DNA was associated with a failure to seroconvert following incident HPV infection; however, some women with persistent HPV DNA never seroconverted. Antibody responses to each type were heterogeneous, but several type-specific differences were found: seroconversion for HPV-16 occurred most frequently between 6 and 12 months of DNA detection, but seroconversion for HPV-6 coincided with DNA detection. Additionally, antibody responses to HPV-16 and -18 were significantly more likely to persist during follow-up than were antibodies to HPV-6.
Carter
J J
JJ
Program in Cancer Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Koutsky
L A
LA
Hughes
J P
JP
Lee
S K
SK
Kuypers
J
J
Kiviat
N
N
Galloway
D A
DA
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002213:Capsid / Q000276:immunology*; D004279:DNA, Viral / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000145:classification / Q000276:immunology*; D030361:Papillomavirus Infections / Q000276:immunology*; D014412:Tumor Virus Infections / Q000276:immunology*
D000914:Antibodies, Viral; D004279:DNA, Viral