A model of the endogenous glucose balance incorporating the characteristics of glucose transporters.
This paper describes the development and preliminary test of a model of the endogenous glucose balance that incorporates the characteristics of the glucose transporters GLUT1, GLUT3 and GLUT4. In the modeling process the model is parameterized with nine parameters that are subsequently estimated from data in the literature on the hepatic- and endogenous- balances at various combinations of blood glucose and insulin levels. The ability of the resulting endogenous balance to fit blood glucose measured from patients was tested on 20 patients. The fit obtained with this model compared favorably with the fit obtained with the endogenous balance currently incorporated in the DIAS system.
Arleth
T
T
Department of Medical Informatics, Institut 8, Aalborg University, Frb 7, rum D2 219, 9100, Aalborg, Denmark. ta@miba.auc.dk
Andreassen
S
S
Federici
M O
MO
Benedetti
M M
MM
D001693:Biological Transport, Active; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009004:Monosaccharide Transport Proteins / Q000378:metabolism*
D007328:Insulin; D009004:Monosaccharide Transport Proteins; D005947:Glucose