Treatment of acoustic trauma.
The aim of this study is to determine the actual efficiency of the present medical treatments of acoustic trauma. Untreated and treated groups of guinea pigs are exposed to a traumatic noise exposure, inducing up to 60-dB threshold shift. The recovery is followed for up to 14 days. The first results indicate that in some animals the recovery of the threshold shifts are complete despite the fact that significant areas of hair cells are damaged. The most widely used medical treatments of acoustic trauma (oxygenotherapy, carbogen, hyperbaric oxygen, vasoactive agents, and corticotherapy) have been tested. Preliminary results indicate that pure oxygen and carbogen seem ineffective, hyperbaric oxygen used alone is dangerous, and corticoids and combined corticoid/hyperbaric oxygen seem to improve functional and morphological recovery. This study will be taken as a reference to look for new treatments that will be applied directly to the cochlea by means of an implanted osmotic micropump.
d'Aldin
C
C
Physiology Group, French-German Research Institute of Saint-Louis, France.
Cherny
L
L
Devrière
F
F
Dancer
A
A
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000502:physiology; D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000628:therapy*; D006931:Hyperbaric Oxygenation
D005938:Glucocorticoids