[The diagnostic significance of immunogenetic markers in vertebrogenic neurological syndromes].
A total of 116 patients presenting with different neurological syndromes of vertebral osteochondrosis were examined. More common in patients with reflex neurological manifestations of osteochondrosis compared with controls (n = 51) was a complete HLA phenotype (heterozygosity) determining better evolutional and biological resistance to injuring factors and ability to produce adequate adaptive and compensatory reactions. The diagnosing of incomplete phenotype in other groups indicated homozygosity of genes and suggested a high risk for development of the disorder. Criteria have been established for a relative risk of development of the disease for all six vertebrogenic neurological syndromes.
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D015415:Biomarkers / Q000097:blood; D006680:HLA Antigens / Q000097:blood; D006239:Haplotypes; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000209:etiology; D010007:Osteochondritis / Q000150:complications* / Q000276:immunology; D010641:Phenotype; D012307:Risk Factors; D013166:Spondylitis / Q000150:complications* / Q000276:immunology; D013577:Syndrome
D015415:Biomarkers; D006680:HLA Antigens