title: Early detection of neurophysiological abnormalities in infection by human immunodeficiency virus.
abstract: The human immunodeficiency virus causes serious, progressive and irreversible deterioration of the immunocompetence system and of the nervous system, so neurological pathology in infected patients is frequent (30-40%), affecting both the central and the peripheral nervous systems. There are different clinical and laboratory indicators of bad prognosis, considering the important neurotropism of the virus. This study attempts to evaluate which neurophysiological parameters are altered during the initial phases of infection by HIV. A total of 46 individuals were studied, 30 seronegative and 16 seropositive in stage A of the CDC-93 classification. Motor and sensory conduction studies were carried out on all of them on the upper and lower extremities, as well as visual, somatosensory and auditory evoked potentials and endogenous potentials, mainly P300. The analysis of the neurophysiological parameters evaluated in our series, showed alterations of the conduction velocity of the sural nerve, latency of N1 of the SSEP of median and posterior tibial nerves and P300 in the initial phases of the infection even in the absence of clinical symptomatology.
authors.affiliation: Clinical Neurophysiology Service, Hospital Clinico Universitario, Zaragoza, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Aznar-Bueno
authors.forename: F
authors.initials: F
authors.lastname: Abad-Alegría
authors.forename: J A
authors.initials: JA
authors.lastname: Amiguet
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018450:Disease Progression; D004594:Electrophysiology; D005071:Evoked Potentials; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000503:physiopathology; D018023:HIV Seronegativity; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009422:Nervous System Diseases / Q000209:etiology* / Q000503:physiopathology; D009431:Neural Conduction; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000503:physiopathology