Seizure-inducing paradoxical reaction to antiepileptic drugs.
We report on an 18-month-old girl with a seizure frequency of five/day, receiving an antiepileptic polytherapy consisting of primidone, clonazepam and phenytoin. Following discontinuation of clonazepam and primidone, the patient has been seizure-free under monotherapy for 2 years and shows marked developmental progress. Possible mechanisms of this paradoxical effect of antiepileptic drugs and the implications for antiepileptic therapy are discussed.
Borusiak
P
P
Zentrum für Kinder-und Jugendmedizin Wuppertal, Germany. borusiak@klinikum-wuppertal.de
Bettendorf
U
U
Karenfort
M
M
Korn-Merker
E
E
Boenigk
H E
HE
D000927:Anticonvulsants / Q000009:adverse effects*; D002998:Clonazepam / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007223:Infant; D010672:Phenytoin / Q000009:adverse effects*; D011324:Primidone / Q000009:adverse effects*
D000927:Anticonvulsants; D011324:Primidone; D002998:Clonazepam; D010672:Phenytoin