Annular erythema of Sjögren's syndrome in a white woman.
Annular erythema of Sjögren's syndrome (AE-SS) is believed to be the Asian counterpart of subacute cutaneous lupus erythematosus (SCLE) in white persons. We report the second case of a white person with AE-SS, diagnosed by clinical and serologic findings, as well as the absence of histologic criteria for SCLE. The diagnosis of AE-SS was established by symptoms of xerophthalmia and xerostomia, as well as by examination of skin and salivary gland biopsy specimens. Evaluation showed the presence of anti-Ro(SS-A) and anti-La(SS-B) autoantibody, with the presence of anti-Ro(SS-A) antibody against the 60-kd, but not the 52-kd, epitope, a pattern frequently seen in both the Asians with AE-SS and in white patients with SCLE. Both skin and sicca symptoms were alleviated with combination antimalarial therapy, which included hydroxychloroquine and quinacrine. This case demonstrates that AE-SS can occur in white patients and that the autoantibody profile is similar to that described in Asians with this disease.
Haimowitz
J E
JE
Department of Dermatology, University of Pennsylvania, Cooper Medical Center, Philadelphia 19104, USA.
McCauliffe
D P
DP
Seykora
J
J
Werth
V P
VP
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D004890:Erythema / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000150:complications*; D012867:Skin / Q000473:pathology; D044465:White People
D001323:Autoantibodies