title: Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug.
abstract: Investigation of the Chinese crude drug "Xiebai," the bulbs of Allium chinense G. Don (Liliaceae), led to the isolation of 2 saponins, xiebai-saponin I (laxogenin 3-O-beta-xylopyranosyl (1-->4)-[alpha-arabinopyranosyl (1-->6)-beta-glucopyranoside) (1) and laxogenin 3-O-alpha-arabinopyranosyl (1-->6)-beta-glucopyranoside (2), and the aglycone, laxogenin (3), together with 2 chalcones, isoliquiritigenin (4) and isoliquiritigenin-4-O-glucoside (5), and beta-sitosterol glucoside (6). Compounds 1-5 were tested in vitro for their inhibitory effect on the 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32Pi-incorporation into phospholipids of HeLa cells. In addition to this, laxogenin (3) was proven to have an antitumor-promoting activity in a two-stage lung carcinogenesis experiment.
authors.affiliation: Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: M
authors.initials: M
authors.lastname: Ohmura
authors.forename: N
authors.initials: N
authors.lastname: Kishi
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: S
authors.initials: S
authors.lastname: Shibata
authors.forename: J
authors.initials: J
authors.lastname: Peng
authors.forename: S S
authors.initials: SS
authors.lastname: Yao
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: T
authors.initials: T
authors.lastname: Okuyama
mesh_terms: D000490:Allium / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D047188:Chalcones; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D012503:Saponins / Q000494:pharmacology*; D013150:Spirostans / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D047188:Chalcones; D004365:Drugs, Chinese Herbal; D012503:Saponins; D013150:Spirostans; C410957:laxogenin; D002599:Chalcone; C040920:isoliquiritigenin