[Evaluation of methods of trace analysis of various opiates including hydrocodone and hydromorphone in the blood and urine using gas chromatography-mass spectrometry].
A GC-MS method suitable to conduct practical trace toxicological analyses of various opiates including hydrocodone or hydromorphone is presented both in scan and selected ion monitoring modes. Silylation can be a convenient reaction to derivatize unknown analytes in toxicological samples. However, silylation of drugs with tautomeric keto/enol groups in molecular structure can cause analytical problems due to poor reproducibility of conversion degree. After using N-Methyl-N-trimethyl-silyltrifluoracetamide (MSTFA) acceptable results were achieved.
Balíková
M
M
Ustav pro toxikologii a soudní chemii, 1. LF UK a VFN, Praha.
Maresová
V
V
Habrdová
V
V
D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D006853:Hydrocodone / Q000032:analysis; D004091:Hydromorphone / Q000032:analysis; D009294:Narcotics / Q000032:analysis*; D015813:Substance Abuse Detection
D009294:Narcotics; D006853:Hydrocodone; D004091:Hydromorphone