In vivo and in vitro investigations into the biosynthetic relatedness of the pseudopterosins.
[formula: see text] Both in vivo and in vitro techniques have been developed to test putative intermediates in the biosynthetic pathway to the pseudopterosins, antiinflammatory compounds isolated from Pseudopterogorgia elisabethae. Furthermore, specific activity data we have obtained indicate that pseudopterosin A is a precursor to pseudopterosins B, C, and D. We conclude that in the biosynthesis xylose is attached to the diterpene skeleton to produce pseudopterosin A and is then aceylated to form pseudopterosins B-D.
Coleman
A C
AC
Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton 33431, USA.
Mydlarz
L D
LD
Kerr
R G
RG
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D003063:Cnidaria / Q000737:chemistry*; D007189:Indans / Q000737:chemistry*; D011106:Polyisoprenyl Phosphates / Q000737:chemistry; D014994:Xylose / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D007189:Indans; D011106:Polyisoprenyl Phosphates; D014994:Xylose; C002963:geranylgeranyl pyrophosphate