title: Assessment of coronary arterial restenosis with phase-contrast magnetic resonance imaging measurements of coronary flow reserve.
abstract: BACKGROUND
  After successful percutaneous coronary arterial revascularization, 25% to 60% of subjects have restenosis, a recurrent coronary arterial narrowing at the site of the intervention. At present, restenosis is usually detected invasively with contrast coronary angiography. This study was performed to determine if phase-contrast MRI (PC-MRI) could be used to detect restenosis noninvasively in patients with recurrent chest pain after percutaneous revascularization.
  
  
  RESULTS
  Seventeen patients (15 men, 2 women, age 36 to 77 years) with recurrent chest pain >3 months after successful percutaneous intervention underwent PC-MRI measurements of coronary artery flow reserve followed by assessments of stenosis severity with computer-assisted quantitative coronary angiography. The intervention was performed in the left anterior descending coronary artery in 15 patients, one of its diagonal branches in 2 patients, and the right coronary artery in 1 patient. A PC-MRI coronary flow reserve value </=2.0 was 100% and 82% sensitive and 89% and 100% specific for detecting a luminal diameter narrowing of >/=70% and >/=50%, respectively.
  
  
  CONCLUSIONS
  Assessments of coronary flow reserve with PC-MRI can be used to identify flow-limiting stenoses (luminal diameter narrowings >70%) in patients with recurrent chest pain in the months after a successful percutaneous intervention.
authors.affiliation: Department of Internal Medicine, Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA. ghundley@wfubmc.edu
authors.forename: W G
authors.initials: WG
authors.lastname: Hundley
authors.forename: L D
authors.initials: LD
authors.lastname: Hillis
authors.forename: C A
authors.initials: CA
authors.lastname: Hamilton
authors.forename: R J
authors.initials: RJ
authors.lastname: Applegate
authors.forename: D M
authors.initials: DM
authors.lastname: Herrington
authors.forename: G D
authors.initials: GD
authors.lastname: Clarke
authors.forename: G A
authors.initials: GA
authors.lastname: Braden
authors.forename: M S
authors.initials: MS
authors.lastname: Thomas
authors.forename: R A
authors.initials: RA
authors.lastname: Lange
authors.forename: R M
authors.initials: RM
authors.lastname: Peshock
authors.forename: K M
authors.initials: KM
authors.lastname: Link
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012008:Recurrence