title: Near-maximal fractional oxygen extraction by active skeletal muscle in patients with chronic heart failure.
abstract: Systemic oxygen uptake and deep femoral vein oxygen content were determined at peak exercise in 53 patients with chronic heart failure with impaired systolic function (mean left ventricular ejection fraction 0.18; n = 41) or preserved systolic function (mean left ventricular ejection fraction 0.70; n = 12) and in 6 age-matched sedentary normal subjects. At peak exercise, deep femoral vein oxygen content in heart failure patients with impaired systolic function and preserved systolic function were similar, both significantly lower than that of normal subjects (2.5 +/- 0.1, 2.9 +/- 0.2, and 5.0 +/- 0.1 ml/100 ml, respectively; P < 0.05). Deep femoral venous oxygen content was lower in patients with the greater impairment of aerobic capacity, regardless of the underlying systolic function (r = 0.72, P < 0.01). Fractional oxygen extraction in the skeletal muscle at peak exercise is enhanced in patients with chronic heart failure when compared with normal subjects, in proportion to the degree of aerobic impairment.
authors.affiliation: Department of Medicine, Columbia University College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York 10032, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Katz
authors.forename: C
authors.initials: C
authors.lastname: Maskin
authors.forename: G
authors.initials: G
authors.lastname: Jondeau
authors.forename: T
authors.initials: T
authors.lastname: Cocke
authors.forename: R
authors.initials: R
authors.lastname: Berkowitz
authors.forename: T
authors.initials: T
authors.lastname: LeJemtel
mesh_terms: D000368:Aged; D002303:Cardiac Output, Low / Q000378:metabolism* / Q000503:physiopathology; D002908:Chronic Disease; D015444:Exercise / Q000502:physiology; D005260:Female; D005268:Femoral Vein; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011659:Pulmonary Gas Exchange; D013599:Systole
chemical_list: D010100:Oxygen