Past use of erythromycin, tetracycline, or doxycycline is not associated with risk of first myocardial infarction.
A population-based case-control study of patients enrolled at Group Health Cooperative of Puget Sound was conducted to evaluate whether past use of antibiotics active against Chlamydia pneumoniae is associated with a decrease in the risk of first myocardial infarction (MI). Cases with incident fatal and nonfatal MI from mid-1986 through 1995 (n=1796) were compared with randomly sampled controls frequency-matched to cases for age, sex, and year (n=4882). Use of erythromycin, tetracycline, or doxycycline during the previous 5 years was not associated with an alteration in the risk of first MI. In an adjusted logistic regression model, the odds ratios and 95% confidence intervals for categories of cumulative duration of therapy with any of the three agents combined for 0, 1-14, 15-28, and >/=29 days were 1.0 (reference), 0.93 (0.81-1.07), 0.99 (0.81-1.20), and 1.03 (0.84-1.26), respectively. These results suggest little or no association between past use of erythromycin or tetracycline antibiotics and the risk of first MI among this population.
Jackson
L A
LA
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, and Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA 98101-1448, USA.
Smith
N L
NL
Heckbert
S R
SR
Grayston
J T
JT
Siscovick
D S
DS
Psaty
B M
BM
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000188:drug therapy*; D016993:Chlamydophila pneumoniae; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D009203:Myocardial Infarction / Q000453:epidemiology; D012307:Risk Factors; D013752:Tetracycline / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004917:Erythromycin; D013752:Tetracycline; D004318:Doxycycline