The stability of remifentanil hydrochloride and propofol mixtures in polypropylene syringes and polyvinylchloride bags at 22 degrees-24 degrees C.
Remifentanil and propofol mixtures may be prepared extemporaneously. This study demonstrated that such mixtures are stable for 0 to 36 h, depending on relative concentrations of the drugs and the storage container used. The most stable mixtures were stored in syringes and used large concentrations of the two drugs.
Stewart
J T
JT
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia, Athens, Georgia 30602-2352, USA. Jstewart@rx.uga.edu
Warren
F W
FW
Maddox
F C
FC
Viswanathan
K
K
Fox
J L
JL
D018686:Anesthetics, Intravenous / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004349:Drug Packaging; D004355:Drug Stability; D010880:Piperidines / Q000737:chemistry*; D011126:Polypropylenes; D011143:Polyvinyl Chloride; D015742:Propofol / Q000737:chemistry*; D000077208:Remifentanil; D013594:Syringes; D013696:Temperature
D018686:Anesthetics, Intravenous; D004338:Drug Combinations; D010880:Piperidines; D011126:Polypropylenes; D011143:Polyvinyl Chloride; D000077208:Remifentanil; D015742:Propofol