title: Synthesis of periphery-functionalized dendritic molecules using polylithiated dendrimers as starting material
abstract: A general method for the functionalization of Si-Cl terminated carbosilane dendritic molecules via organolithium or organomagnesium reagents is described. Quantitative exchange of the bromine atoms of 4-bromophenyl-functionalized dendrimers affords polylithiated species that are valuable starting materials for further functionalization, e.g., into pyridyl alcohols. The latter were successfully applied as catalyst precursors in a ruthenium-mediated ring-closure metathesis reaction.
authors.affiliation: Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, and Ciba Specialty Chemicals, Building K-420, CH-4002 Basel, Switzerland.
authors.initials: P
authors.lastname: Wijkens
authors.initials: JT
authors.lastname: Jastrzebski
authors.lastname: van Der Schaaf PA
authors.initials: R
authors.lastname: Kolly
authors.initials: A
authors.lastname: Hafner
authors.lastname: van Koten G