[Effect of amizon on structural modifications of liver nuclear chromatin from rats, intoxicated with tetrachloromethane].
The actions of the amizon on the antioxidant activity and free radicaloformation level in the nuclear chromatin fractions of rat liver methan tetrachlorid intoxication was studied using the Fe(+2)-induction biochemiluminescence and microcalorimetry methods. The amizon genomoprotective effect on the chromatin transcriptionally active fraction was shown.
Hubskiyĭ
Iu I
IuI
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
Horiushko
A H
AH
Vistunova
I Ie
IIe
Marchenko
O M
OM
Kurapova
T M
TM
Danylenko
V P
VP
Sachenko
L H
LH
D000818:Animals; D002151:Calorimetry; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008163:Luminescent Measurements; D008297:Male; D011487:Protein Conformation; D011725:Pyridines / Q000494:pharmacology*; D011726:Pyridinium Compounds; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic
D002843:Chromatin; D011725:Pyridines; D011726:Pyridinium Compounds; C410106:enisamium