title: New 7,20:14,20-diepoxy ent-kauranoids from Isodon xerophilus.
abstract: Three new 7,20:14,20-diepoxy-ent-kaurane diterpenoids, xerophilusins A-C (1-3), together with a known one, macrocalin B (4), were isolated from the leaves of Isodon xerophilus. Their structures were elucidated on the basis of their spectral properties and X-ray crystallographic analysis. Compounds 1, 2, and 4 showed significant cytotoxic activity against K562, HL-60, and MKN-28 cells.
authors.affiliation: Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming 650204, Yunnan, People's Republic of China.
authors.forename: A J
authors.initials: AJ
authors.lastname: Hou
authors.forename: M L
authors.initials: ML
authors.lastname: Li
authors.forename: B
authors.initials: B
authors.lastname: Jiang
authors.forename: Z W
authors.initials: ZW
authors.lastname: Lin
authors.forename: S Y
authors.initials: SY
authors.lastname: Ji
authors.forename: Y P
authors.initials: YP
authors.lastname: Zhou
authors.forename: H D
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008942:Mitoxantrone / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C410910:xerophilusin A; C410911:xerophilusin B; C410912:xerophilusin C; C045862:macrocalin B; D008942:Mitoxantrone