Protein sorting: recognizing mitochondrial presequences.
The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting 'presequence' provides exciting insight into the molecular mechanism of signal recognition.
Pfanner
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Institut für Biochemie und Molekularbiologie, Universität Freiburg, Germany. pfanner@uni-freiburg.de
D000444:Aldehyde Dehydrogenase / Q000737:chemistry / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D007425:Intracellular Membranes / Q000502:physiology* / Q000648:ultrastructure; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure; D008954:Models, Biological; D011487:Protein Conformation; D011498:Protein Precursors / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
D011498:Protein Precursors; D000444:Aldehyde Dehydrogenase