title: Application of ligand-exchange capillary electrophoresis to the chiral separation of alpha-hydroxy acids and beta-blockers.
abstract: The application of the principle of ligand-exchange capillary electrophoresis to two substance classes is described. As chiral selector N-(2-hydroxyoctyl)-L-4-hydroxyproline-copper(II) complex was used. This principle was applied to the chiral separation of alpha-hydroxy acids and drugs containing amino alcohol structure such as beta-blockers. The enantioselectivity was found to be strongly dependent on pH corresponding to the optimal conditions for complex formation for each structure class.
authors.affiliation: Institute of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria.
authors.forename: M G
authors.initials: MG
authors.lastname: Schmid
authors.forename: O
authors.initials: O
authors.lastname: Lecnik
authors.forename: U
authors.initials: U
authors.lastname: Sitte
authors.forename: G
authors.initials: G
authors.lastname: Gübitz
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000302:isolation & purification*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006880:Hydroxy Acids / Q000302:isolation & purification*; D008024:Ligands; D013237:Stereoisomerism
chemical_list: D000319:Adrenergic beta-Antagonists; D006880:Hydroxy Acids; D008024:Ligands