title: Lack of mutagenic activity of 1,6-hexamethylene diisocyanate.
abstract: 1,6-Hexamethylene diisocyanate (HDI) is an aliphatic diisocyanate used in the manufacture of higher molecular weight biuret and trimer polyisocyanate resins. These resins are commonly used in polyurethane paints, resulting in potential occupational, and to a lesser extent consumer exposures. Because some isocyanates have been reported to be mutagenic, HDI was tested in the bacterial reverse mutation assay (Ames test), CHO/HGPRT gene mutation assay, and in the mouse micronucleus test, using vapor-phase exposures. Although indicators of toxicity were observed in each test, HDI did not induce mutagenic or clastogenic effects in any of the three assays.
authors.affiliation: BioReliance Corporation, Rockville, Maryland 20850, USA.
authors.forename: V O
authors.initials: VO
authors.lastname: Wagner
authors.forename: R H
authors.initials: RH
authors.lastname: San
authors.forename: R
authors.initials: R
authors.lastname: Gudi
authors.forename: R J
authors.initials: RJ
authors.lastname: Hilaski
authors.forename: D
authors.initials: D
authors.lastname: Jacobson-Kram
mesh_terms: D000280:Administration, Inhalation; D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects; D016466:CHO Cells / Q000187:drug effects / Q000201:enzymology; D006224:Cricetinae; D003485:Cyanates / Q000633:toxicity*; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D017953:Isocyanates; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D015996:Survival Rate
chemical_list: D000393:Air Pollutants; D003485:Cyanates; D017953:Isocyanates; D009153:Mutagens; C015262:1,6-hexamethylene diisocyanate; D007041:Hypoxanthine Phosphoribosyltransferase