title: Monoclonal cryoglobulinemia with extensive gangrene of all four extremities--a case report.
abstract: The monoclonal immunoglobulin products of plasma cell neoplasm can give rise to a variety of manifestations including hyperviscosity, amyloidosis, cryoglobulinemia, neuropathy, and renal failure. A 50-year-old woman with monoclonal cryoglobulinemia developed extensive gangrene and ulceration of both hands and feet over several weeks requiring bilateral below-elbow and below-knee amputations. This case illustrates the importance of qualitative properties of paraprotein.
authors.affiliation: Department of Medicine, Coney Island Hospital, Brooklyn, New York 11235, USA.
authors.forename: J
authors.initials: J
authors.lastname: Sanmugarajah
authors.forename: S
authors.initials: S
authors.lastname: Hussain
authors.forename: J M
authors.initials: JM
authors.lastname: Schwartz
authors.forename: S
authors.initials: S
authors.lastname: Friedman
mesh_terms: D000671:Amputation, Surgical; D003449:Cryoglobulinemia / Q000097:blood / Q000175:diagnosis*; D005260:Female; D005528:Foot / Q000098:blood supply* / Q000601:surgery; D005734:Gangrene / Q000175:diagnosis* / Q000601:surgery; D006225:Hand / Q000098:blood supply* / Q000473:pathology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000097:blood*; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood / Q000175:diagnosis*
chemical_list: D007145:Immunoglobulin kappa-Chains