title: [The compound A concentration in a low-flow anesthesia circuit using the new CO2 absorbent SPHERASORB].
abstract: CO2 absorbents convert sevoflurane to fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (compound A), whose toxicity in rats raises concern regarding the safety of sevoflurane in a low-flow system. SPHERASORB is a new CO2 absorbent which does not contain KOH. However, the reaction between SPHERASORB and sevoflurane has not been examined. We compared compound A concentration in a model circuit using SPHERASORB and the commonly used Sodasorb II. The anesthesia circuit was circulated with fresh gas flow at a rate of 1 l.min-1 containing 2% sevoflurane. Compound A concentration was measured hourly and the temperature of CO2 absorbent was monitored. The maximum concentration of compound A in the circuit was 12.2 +/- 1.4 ppm for SPHERASORB and 18.6 +/- 0.4 ppm for Sodasorb II (P < 0.05). The maximum temperature of SPHERASORB was lower than that of Sodasorb II (P < 0.05). SPHERASORB can reduce compound A formation, compared to Sodasorb II.
authors.affiliation: Department of Anesthesiology, Seirei Mikatahara Hospital, Hamamatsu.
authors.forename: R
authors.initials: R
authors.lastname: Obata
authors.forename: H
authors.initials: H
authors.lastname: Bito
authors.forename: T
authors.initials: T
authors.lastname: Katoh
authors.forename: S
authors.initials: S
authors.lastname: Sato
mesh_terms: D000042:Absorption; D000764:Anesthesia, Closed-Circuit; D018685:Anesthetics, Inhalation; D000818:Animals; D002245:Carbon Dioxide; D004987:Ethers / Q000032:analysis*; D006845:Hydrocarbons, Fluorinated / Q000032:analysis*; D008738:Methyl Ethers; D051381:Rats; D000077149:Sevoflurane; D013696:Temperature
chemical_list: D018685:Anesthetics, Inhalation; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; C078742:fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether