C-nociceptor sensitization by isoprostanes is cyclooxygenase dependent.
Isoprostane E(2) (8-iso-PGE) and F(2alpha) (8-iso-PGF) sensitize nociceptors and capsaicin-sensitive DRG neurons. In this study we investigated the cyclooxygenase-dependence of isoprostane-induced C-nociceptor sensitization. Systemic pretreatment of rats with ketorolac (1 and 10 mg/kg) abolished 8-iso-PGF sensitization and reduced the effects of 8-iso-PGE. Ibuprofen (30 mg/kg) blocked all sensitizing effects. These data suggest that some algesic properties of isoprostanes are mediated via prostanoid synthesis.
Junger
H
H
Department of Anesthesiology, University of California, San Diego, CA, USA.
Sorkin
L S
LS
D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives / Q000494:pharmacology; D015232:Dinoprostone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D028441:F2-Isoprostanes; D005727:Ganglia, Spinal / Q000166:cytology; D006930:Hyperalgesia / Q000139:chemically induced; D028421:Isoprostanes; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
D028441:F2-Isoprostanes; D028421:Isoprostanes; D014662:Vasoconstrictor Agents; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone; C011987:8-isoprostaglandin E2