title: Occult retinal pigment epithelial detachment in hyperviscosity syndrome.
abstract: We document and evaluate a serous retinal detachment in a patient with hyperviscocity syndrome. Optical coherence tomographic images of the serous retinal detachment in a patient with hyperviscocity syndrome were correlated with slit-lamp biomicroscopic findings, fundus photographs, fluorescein angiograms, and indocyanine green angiograms. Fluorescein angiography demonstrated venous and capillary bed abnormalities but no leakage or pooling of fluorescein corresponding to the retinal pigment epithelial detachment (PED) beneath the serous retinal detachment. Indocyanine green angiogram disclosed a delay of intrachoroidal circulation. Optical coherence tomography (OCT) revealed a large retinal pigment epithelial detachment beneath the serous retinal detachment. The occult retinal PED beneath the neurosensory retinal detachment was detected only by OCT in a patient with hyperviscosity syndrome. We suggest that gamma globulin, which is the hyperviscosity material, accumulated in the subretinal pigment epithelial space and blocked the leakage or pooling of fluorescein corresponding to the retinal pigment epithelial detachment.
authors.affiliation: Department of Ophthalmology, Kansai Medical University, Moriguchi, Osaka, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ogata
authors.forename: H
authors.initials: H
authors.lastname: Ida
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Fukuchi
authors.forename: M
authors.initials: M
authors.lastname: Uyama
mesh_terms: D003937:Diagnosis, Differential; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye / Q000378:metabolism / Q000473:pathology*; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D013577:Syndrome; D014054:Tomography; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D005719:gamma-Globulins / Q000378:metabolism*
chemical_list: D005719:gamma-Globulins