Evidence for presence of IgG4 anti-immunoglobulin autoantibodies in all human beings.
IgG4 anti-IgG autoantibodies were found to be present in all serum samples from a group of healthy people; IgG4 ant-IgA and anti-IgE were present In only 13 of 218 (6%) and 8 of 218 (3.5%) samples, respectively. These antibodies also showed affinities towards animal immunoglobulins. We suggest that IgG4 anti-IgA antibodies (the strongest found heterophilic Immunoglobulins) are responsible for most artifacts obtained with commercial EUSA systems.
Hennig
C
C
Rink
L
L
Kirchner
H
H
D000888:Antibodies, Anti-Idiotypic / Q000302:isolation & purification*; D000915:Antibody Affinity; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G
D000888:Antibodies, Anti-Idiotypic; D007074:Immunoglobulin G