Glucose stimulates the release of bombyxin, an insulin-related peptide of the silkworm Bombyx mori.
The effects of starvation and feeding on the release of bombyxin, a peptide of insulin superfamily in insects, from the larval brain of the silkworm Bombyx mori were investigated. Following starvation, the bombyxin titer in the hemolymph of larvae decreased, whereas its content in the brain increased. On the other hand, refeeding of the starved larvae resulted in an increase in the hemolymph bombyxin titer and a rapid decrease in the hormone level in the brain. These results indicate that the release of bombyxin from the brain is suppressed by starvation and stimulated by feeding. The hemolymph glucose titer also changed sharply upon starvation and refeeding, and a close relationship was observed between the changes in glucose concentrations and bombyxin titers in the hemolymph. The injection of glucose into starved larvae could mimic the effect of refeeding on the release of bombyxin, suggesting that glucose serves as the signal for the "fed" state of the animal. It is likely that glucose is a common nutritional signal for inducing the release of mammalian and insect insulins.
Masumura
M
M
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa-ku, Japan.
Satake
S
S
Saegusa
H
H
Mizoguchi
A
A
D000818:Animals; D012831:Bombyx; D001921:Brain / Q000378:metabolism; D005260:Female; D005502:Food; D005508:Food Deprivation; D005947:Glucose / Q000494:pharmacology*; D006458:Hemolymph / Q000378:metabolism; D007814:Larva / Q000187:drug effects / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism*
D009479:Neuropeptides; C075028:bombyxins; D005947:Glucose