Leukemia-associated gene rearrangements in blood mononuclears of subjects in long terms after radiation exposure.
The results of electron microscopy and molecular genetic study of blood mononuclears of 220 clean-up workers after 7-10 years since Chernobyl accident are presented. An increase of lymphocytes with altered ultrastructure of nuclei and membrane has been observed. Structural polymorphism of leukemia associated bcr and rRNA genes has been analyzed using Southern blot hybridization. Allelic polymorphism of bcr gene with allele distribution characteristic of myeloid leukemia and rearrangements of rRNA genes have been revealed in 11,5% of clean-up workers under study.
Butenko
Z A
ZA
Dept. of Leukemogenesis Mechanisms, R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv.
Smirnova
I A
IA
Zak
K P
KP
Kishinskaja
E G
EG
Janok
E A
EA
D015321:Gene Rearrangement; D020022:Genetic Predisposition to Disease; D006801:Humans; D007953:Leukemia, Radiation-Induced / Q000097:blood / Q000235:genetics* / Q000473:pathology; D007963:Leukocytes, Mononuclear; D011210:Power Plants; D018788:Radioactive Hazard Release; D013997:Time Factors; D014455:Ukraine