Photosensitive mycosis fungoides or actinic reticuloid?
We report two patients who satisfied the diagnostic criteria for actinic reticuloid (AR) on initial presentation, in whom genotypic analysis of early skin biopsies failed to show T-cell gene receptor rearrangements. Both patients progressed to widespread skin involvement associated with histopathological and genotypic features of mycosis fungoides (MF). Arguably, these patients may have had photosensitive MF from the outset, but their clinical features, phototesting, and subsequent demonstration of a T-cell gene receptor rearrangement in the skin could also suggest progression of AR to MF.
De Silva
B D
BD
Departments of Dermatology and Pathology, The Royal Infirmary of Edinburgh, Lauriston Place, Edinburgh EH3 9YW, U.K. bdes@excite.com
McLaren
K
K
Kavanagh
G M
GM
D000368:Aged; D003937:Diagnosis, Differential; D018450:Disease Progression; D006801:Humans; D008297:Male; D009182:Mycosis Fungoides / Q000175:diagnosis* / Q000473:pathology; D010787:Photosensitivity Disorders / Q000175:diagnosis* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology