title: [Atypical meningioma: morphometric analysis of nuclear pleomorphism].
abstract: The revised edition of the WHO classification of brain tumours now includes the "atypical" meningioma (grade II) which should be placed between the common type (grade I) and anaplastic type (grade III) according to histomorphological features and prognosis. However, diagnostic criteria for atypical meningioma are vague and the significance of brain invasion in the determination of malignancy is controversial. Nuclear pleomorphism and mitoses are usually considered the most important parameters to distinguish atypical and malignant meningiomas. According to WHO classification we selected eight cases of meningioma diagnosed as atypical (3 cases) and malignant (5 cases). All the tumours were supratentorially located. Nine cases of benign meningiomas were also studied as a control group. Morphometrical analysis was carried out by S.A.M. (Shape Analytical Morphometry) system. S.A.M. logical architecture assumes that each irregular shape contains elements of two distinct logical domains: gross distortions that interest the contour and its local perturbations. These features were investigated separately by analytical procedures to acquire independent parameters both on the logical and the numerical level. The results, statistically evaluated, show that nuclear pleomorphism is not a satisfactory criterion, if used alone, to distinguish atypical from malignant meningioma (Discriminant Analysis: 19% of minimum error).
authors.affiliation: Istituto di Anatomia Patologica, Università, Bari. a.pennella@anatopat.uniba.it
authors.forename: A
authors.initials: A
authors.lastname: Pennella
authors.forename: C
authors.initials: C
authors.lastname: Ferri
authors.forename: T
authors.initials: T
authors.lastname: Lettini
authors.forename: G
authors.initials: G
authors.lastname: Serio
authors.forename: A
authors.initials: A
authors.lastname: Cimmino
authors.forename: D M
authors.initials: DM
authors.lastname: Caniglia
authors.forename: F
authors.initials: F
authors.lastname: Giangaspero
authors.forename: R
authors.initials: R
authors.lastname: Ricco
mesh_terms: D001932:Brain Neoplasms / Q000145:classification / Q000473:pathology*; D006801:Humans; D008579:Meningioma / Q000473:pathology*; D009367:Neoplasm Staging