[Total intravenous anesthesia based on propofol infusion with target concentration: a new procedural solution].
Total intravenous propofol anesthesia with target control (TCI) infusion was used in 61 surgical patients (43 women, 18 men, ASAI-II). Propofol concentration in the central compartment at awakening was in high correlation with the effective concentration (Ce) at the moment of falling asleep (r = 0.64). A model investigation demonstrated the advantages of longer induction for minimization of the hemodynamic disorders. Propofol TCI in a dose of 2 micrograms/ml led to an increase in the EEG spectral potency in the 1-12 Hz range, appearance of biomodality, and a decrease in the right-side frequency. The studies helped determine the policy of intravenous propofol TCI anesthesia using the Ce values at the moment when the patient lost consciousness and the right-side frequency of EEG spectrum.
Flerov
E V
EV
Stamov
V I
VI
Tolmachev
K M
KM
Iumatov
A E
AE
Buniatian
A A
AA
D000465:Algorithms; D000771:Anesthesia, Intravenous / Q000379:methods* / Q000706:statistics & numerical data; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004569:Electroencephalography / Q000187:drug effects / Q000706:statistics & numerical data; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013997:Time Factors
D018686:Anesthetics, Intravenous; D015742:Propofol