title: En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B.
abstract: [reaction--see text] Efficient and processable syntheses of key building blocks of the antitumor agent 12,13-desoxyepothilone B (dEpoB) by catalytic asymmetric induction are herein described.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, NY 10021, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Chappell
authors.forename: S J
authors.initials: SJ
authors.lastname: Stachel
authors.forename: C B
authors.initials: CB
authors.lastname: Lee
authors.forename: S J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000191:economics; D034261:Epothilones; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000191:economics; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000191:economics
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; D004852:Epoxy Compounds; D007783:Lactones; D013844:Thiazoles; C114026:desoxyepothilone B; C093788:epothilone B