A study of the adhesive-skin interface: correlation between adhesion and passage of a drug.
The phenomena taking place at the patch-skin interface, in particular the adhesion of a pressure sensitive adhesive (PSA) film loaded with drug and the partition of the drug between the patch and the skin were correlated. The kinetics of adhesion as well as those of drug passage were studied in detail. Adhesion data were collected from peel test either on skin or on a polymer model. Passage of the drug was studied in a simple system composed of PSA film stuck on skin. In some experiments the film was left on the skin throughout the experiment; in others, it was periodically removed and stuck on again to keep the adhesion force constant during the whole of the experiment. We observed a rapid increase of the drug content in the skin until a plateau was reached. One adhesion for the whole experiment or several adhesions gave a similar curve. The main difference was the rate of increase of skin drug content and the value of the plateau. Different hypotheses concerning the relationship between the adhesion of this PSA and changes in the flux of drug have been put forward. However, it is difficult to extrapolate from this model to the in vivo situation because of variation both between individuals and with time.
Maillard-Salin
D G
DG
Hoechst Marion Roussel, Pharmaceutics, Romainville, France.
Bécourt
P
P
Couarraze
G
G
D000268:Adhesiveness; D000279:Administration, Cutaneous; D006801:Humans; D010599:Pharmacokinetics; D011138:Polytetrafluoroethylene; D011397:Promegestone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D012826:Silicone Elastomers; D012869:Skin Absorption / Q000502:physiology*
D012826:Silicone Elastomers; C050319:trimegestone; D011138:Polytetrafluoroethylene; D011397:Promegestone