title: Invasive adenocarcinoma of mixed endocervical and clear cell type, associated with invasive squamous cell carcinoma of the cervix uteri. A case report.
abstract: A case of invasive adenocarcinoma (predominantly of endocervical type but also with clear cell elements blended in part of the growth) associated with squamous cell carcinoma of the uterine cervix is reported in a young woman aged 18 years. Malignant squamous and atypical glandular cells were detected in Papanicolaou (Pap) smears, which raised the question of a mixed tumor. A diagnosis of cervical cancer was justified by means of a punch biopsy and the patient was treated by modified radical hysterectomy. Histologic and immunohistochemical examination of the hysterectomy specimen revealed two distinct types of an invasive malignant tumor, i.e., of glandular and squamous cell origin, closely related but not integrated. Interestingly, the glandular component comprised both endocervical and clear cell elements. Careful consideration of squamous or glandular atypia in cytological smears may lead to a more precise diagnosis, especially in young women.
authors.affiliation: Department of Obstetrics and Gynecology, General Hospital of Alexandroupolis, Democritus University of Thrace, Greece.
authors.forename: P
authors.initials: P
authors.lastname: Anastasiadis
authors.forename: N
authors.initials: N
authors.lastname: Koutlaki
authors.forename: D
authors.initials: D
authors.lastname: Tamiolakis
authors.forename: V
authors.initials: V
authors.lastname: Liberis
authors.forename: G
authors.initials: G
authors.lastname: Galazios
authors.forename: E
authors.initials: E
authors.lastname: Sivridis
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D018262:Adenocarcinoma, Clear Cell / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000379:methods; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D065006:Papanicolaou Test; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery; D014626:Vaginal Smears