Cytotoxic peroxides from Artemisia stolonifera.
Two sesquiterpene endoperoxides, 1S, 4R, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (I), 1R, 4S, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (II), and a sesquiterpene hydroperoxide, 1beta-hydroperoxygermacra-4 (15), 5, 10 (14)-triene (III) were isolated from the aerial parts of Artemisia stolonifera (Compositae). Their chemical structures were assigned by spectral evidences. Compounds I and II exhibited cytotoxicity against five human tumor cell lines with their ED50 values ranging from 0.20 to 5.43 microg/ml and from <0.1 to 0.87 microg/ml, respectively.
Kwon
H C
HC
Natural Products Laboratory, College of Pharmacy, SungKyunKwan University, Suwon, Kyunggi-Do, Korea.
Choi
S U
SU
Lee
K R
KR
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000633:toxicity*; D019306:Artemisia / Q000737:chemistry*; D002855:Chromatography, Thin Layer; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000633:toxicity*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
C412948:4-endoperoxy-bisabola-2,10-diene; D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D004317:Doxorubicin