title: Infraorbital nerve transection increases NADPH-diaphorase activity in the rat mesencephalic trigeminal nucleus.
abstract: Complete information concerning possible alterations in nitric oxide production in the rat brainstem trigeminal system after peripheral nerve lesion is still lacking. This being the case, density of NADPH-diaphorase positive neurons in the trigeminal mesencephalic nucleus after experimental infraorbital nerve transection was studied. In the lesioned side, an ipsilateral increase in NADPH-d positive neurons was found at postoperative days 4 and 6 with respect to contralateral, without changes after a 2 months period. These data suggest that nitric oxide could be involved in regeneration of afferent fibers concerned with the periodontal receptors of maxillary teeth.
authors.affiliation: Department of Physiology, School of Medicine, University of the Basque Country, Bilbao, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: De Gandarias
authors.forename: P L
authors.initials: PL
authors.lastname: Mendez
authors.forename: L
authors.initials: L
authors.lastname: Vegas
authors.forename: E
authors.initials: E
authors.lastname: Echevarría
authors.forename: J L
authors.initials: JL
authors.lastname: Maza
authors.forename: L
authors.initials: L
authors.lastname: Casis
mesh_terms: D000818:Animals; D019771:Axotomy; D002452:Cell Count; D006651:Histocytochemistry; D008297:Male; D008442:Maxillary Nerve / Q000293:injuries / Q000502:physiology* / Q000601:surgery; D008636:Mesencephalon / Q000166:cytology / Q000201:enzymology*; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009412:Nerve Fibers / Q000201:enzymology; D009416:Nerve Regeneration / Q000502:physiology*; D009475:Neurons, Afferent / Q000166:cytology / Q000201:enzymology; D010487:Periaqueductal Gray / Q000166:cytology / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014278:Trigeminal Nuclei / Q000166:cytology / Q000201:enzymology*; D014950:Wounds, Penetrating / Q000503:physiopathology
chemical_list: D009252:NADPH Dehydrogenase