title: Neonatal alloimmune thrombocytopenia due to anti-HPA 1a antibodies; the level of maternal antibodies predicts the severity of thrombocytopenia in the newborn.
abstract: Eleven thousand one hundred pregnant women were genotyped for human platelet antigen HPA 1, and 198 HPA 1bb women were followed in the pregnancy with quantitative assay for anti-HPA la antibodies. Antibodies were detected in 24 women, and nine children were born with severe thrombocytopenia (< 50x10(9)/L). All mothers with high levels of antibodies were delivered of children with severe thrombocytopenia. None of the newborn infants had clinical signs of intra-cranial haemorrhage. The level of maternal anti-HPA 1a antibodies is predictive for fetal thrombocytopenia and may be used in decisions related to time and mode of delivery.
authors.affiliation: Department of Immunology and Transfusion Medicine, University Hospital of Tromsø, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Jaegtvik
authors.forename: A
authors.initials: A
authors.lastname: Husebekk
authors.forename: B
authors.initials: B
authors.lastname: Aune
authors.forename: P
authors.initials: P
authors.lastname: Oian
authors.forename: L B
authors.initials: LB
authors.lastname: Dahl
authors.forename: B
authors.initials: B
authors.lastname: Skogen
mesh_terms: D000906:Antibodies / Q000097:blood*; D016824:Antigens, Human Platelet / Q000097:blood / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D005260:Female; D005838:Genotype; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology*; D011296:Prenatal Diagnosis / Q000379:methods; D013921:Thrombocytopenia / Q000150:complications / Q000175:diagnosis / Q000235:genetics*
chemical_list: D000906:Antibodies; D016824:Antigens, Human Platelet; D015415:Biomarkers