title: Identification and characterization of a potent antibacterial agent, NH125 against drug-resistant bacteria.
abstract: New imidazole compounds were synthesized to develop a novel and effective antibacterial agent (1-benzyl-3-cetyl-2-methylimidazolium iodide, NH125). In vitro experiments demonstrated that NH125 effectively inhibited a number of different histidine protein kinases. Furthermore, oxacillin-resistant Staphylococcus aureus (ORSA), vancomycin-resistant Enterococcus faecalis (VRE), penicillin-resistant Streptococcus pneumoniae (PRS), and other Gram-positive and Gram-negative bacteria were found to be very sensitive to NH125.
authors.affiliation: Department of Agricultural Chemistry, Kinki University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Kitayama
authors.forename: N
authors.initials: N
authors.lastname: Ishida
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Tanabe
authors.forename: M
authors.initials: M
authors.lastname: Takatani
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: R
authors.initials: R
authors.lastname: Utsumi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000071677:Histidine Kinase; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007093:Imidazoles; C414024:NH 125; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D000071677:Histidine Kinase