Cytonic acids A and B: novel tridepside inhibitors of hCMV protease from the endophytic fungus Cytonaema species.
Two novel human cytomegalovirus protease inhibitors, cytonic acids A (1) and B (2), have been isolated from the solid-state fermentation of the endophytic fungi Cytonaema sp. Their structures as p-tridepside isomers were elucidated by MS and NMR methods.
Guo
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B
Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore 118240. bingying@cnpr.nus.edu.sg
Dai
J R
JR
Ng
S
S
Huang
Y
Y
Leong
C
C
Ong
W
W
Carté
B K
BK
D001565:Benzoates / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000378:metabolism*; D011480:Protease Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000378:metabolism*
D001565:Benzoates; D011480:Protease Inhibitors; C410913:cytonic acid A; C410914:cytonic acid B; D012697:Serine Endopeptidases; C071910:assemblin