title: The efficacy of biochemical markers in patients with ossification of posterior longitudinal ligament of the spine.
abstract: METHODS
  Serum levels of carboxyterminal propeptide of type I collagen (PICP), osteocalcin (OC), carboxyterminal telopeptide of type I collagen (ICTP) and urinary levels of pyridinoline (Pyr) and deoxypyridinoline (Dpyr) were measured in patients with ossification of posterior longitudinal ligament of the spine (OPLL) and age-matched control subjects.
  
  
  OBJECTIVE
  To evaluate the efficacy of these biochemical markers of the patients with OPLL.
  
  
  METHODS
  Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  
  
  METHODS
  Spot urine and blood samples were obtained from 20 healthy males aged 45 - 78 (mean+/-SD; 63. 0+/-11.5) and 22 male patients with OPLL aged 46 - 77 (mean+/-SD; 59. 9+/-8.8), and serum levels of PICP, OC, ICTP and urinary levels of Pyr and Dpyr were measured.
  
  
  RESULTS
  There were no significant difference in age, serum PICP, OC, ICTP, urinary Pyr and Dpyr levels between OPLL and control group.
  
  
  CONCLUSIONS
  Neither bone formation nor bone resorption was accelerated in the patients with OPLL.
authors.affiliation: Department of Orthopedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
authors.forename: C
authors.initials: C
authors.lastname: Ishihara
authors.forename: K
authors.initials: K
authors.lastname: Kushida
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: T
authors.initials: T
authors.lastname: Ohishi
authors.forename: H
authors.initials: H
authors.lastname: Murata
authors.forename: A
authors.initials: A
authors.lastname: Nagano
authors.forename: S
authors.initials: S
authors.lastname: Goto
mesh_terms: D000368:Aged; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003094:Collagen / Q000097:blood; D024042:Collagen Type I; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D017887:Ossification of Posterior Longitudinal Ligament / Q000097:blood* / Q000652:urine*; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides / Q000097:blood; D011237:Predictive Value of Tests; D011347:Procollagen / Q000097:blood; D012016:Reference Values
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D003094:Collagen