title: Evidence for mild blue-yellow colour vision deficits immediately following fluorescein angiography.
abstract: OBJECTIVE
  We have investigated the short term effects of fluorescein angiography on the blue-yellow, red-green, and luminance contrast sensitivity of patients with early age-related macular degeneration (ARMD).
  
  
  METHODS
  Nine ARMD patients with no exudative complications and a visual acuity of 20/60 or better in the tested eye were selected. Cardinal colour directions for the isolation of the red-green, blue-yellow and achromatic (luminance) visual mechanisms were determined for each patient. Contrast sensitivity was measured in each cardinal colour direction immediately before and 20 min after standard 20-flash fluorescein angiography.
  
  
  RESULTS
  A significant, albeit mild, reduction for blue-yellow contrast sensitivity following angiography was observed (ANOVA, alpha = 0.05). Fluorescein angiographic exposure had no significant effect on red-green or luminance contrast sensitivity.
  
  
  CONCLUSIONS
  Our results show that fluorescein angiography causes at least a short term deficit selective to blue-yellow contrast sensitivity in our patient group.
authors.affiliation: McGill Vision Research, Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
authors.forename: M J
authors.initials: MJ
authors.lastname: Sankeralli
authors.forename: J C
authors.initials: JC
authors.lastname: Chen
authors.forename: A B
authors.initials: AB
authors.lastname: Metha
authors.forename: K T
authors.initials: KT
authors.lastname: Mullen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003118:Color Perception / Q000187:drug effects; D003117:Color Vision Defects / Q000209:etiology*; D015350:Contrast Sensitivity / Q000187:drug effects; D005451:Fluorescein Angiography / Q000009:adverse effects*; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008875:Middle Aged