title: Determination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of acute and prolonged irradiation.
abstract: Somatic mutant frequencies at glycophorin A (GPA) and T-cell receptor (TCR) loci were assessed. The dependence of the GPA mutant frequency on doses of acute and prolonged irradiation was shown. In the case of acute irradiation the GPA mutant frequency displayed a three-fold greater dose-related increase as compared to prolonged irradiation. A dose-dependent increase in the TCR variant frequency was found only in a group of subjects with recent exposures. In Chernobyl clean-up workers the TCR mutant frequency was significantly higher than in control non-irradiated individuals.
authors.affiliation: Department of Radiation Biochemistry, Medical Radiological Research Center of RAMS, Obninsk, Russia. mrrc@obninsk.ru
authors.forename: A S
authors.initials: AS
authors.lastname: Saenko
authors.forename: I A
authors.initials: IA
authors.lastname: Zamulaeva
authors.forename: S G
authors.initials: SG
authors.lastname: Smirnova
authors.forename: N V
authors.initials: NV
authors.lastname: Orlova
authors.forename: E I
authors.initials: EI
authors.lastname: Selivanova
authors.forename: N P
authors.initials: NP
authors.lastname: Matveeva
authors.forename: M A
authors.initials: MA
authors.lastname: Kaplan
authors.forename: V Y
authors.initials: VY
authors.lastname: Nugis
authors.forename: N M
authors.initials: NM
authors.lastname: Nadezhina
authors.forename: A F
authors.initials: AF
authors.lastname: Tsyb
mesh_terms: D016022:Case-Control Studies; D004307:Dose-Response Relationship, Radiation; D006021:Glycophorins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D014455:Ukraine
chemical_list: D006021:Glycophorins; D011948:Receptors, Antigen, T-Cell