title: The Lynch Syndrome: Melding Natural History and Molecular Genetics to Genetic Counseling and Cancer Control.
abstract: Hereditary nonpolyposis colorectal cancer (HNPCC), also referred to as Lynch syndromes I and II, is an autosomal, dominantly inherited disorder that accounts for approximately 5% of all colorectal cancers. While colorectal cancer is the most frequently occurring malignancy in HNPCC, other types of cancer occur with increased statistical significance. A better understanding of its natural history, particularly early age of onset and the pattern of multiple primary cancer excess, is essential for the diagnosis and management of HNPCC.
authors.affiliation: Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
authors.initials: HT
authors.lastname: Lynch
authors.initials: JF
authors.lastname: Lynch