title: Pharmacogenetic prediction of clozapine response.
abstract: We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/- 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.
authors.forename: M J
authors.initials: MJ
authors.lastname: Arranz
authors.forename: J
authors.initials: J
authors.lastname: Munro
authors.forename: J
authors.initials: J
authors.lastname: Birkett
authors.forename: A
authors.initials: A
authors.lastname: Bolonna
authors.forename: D
authors.initials: D
authors.lastname: Mancama
authors.forename: M
authors.initials: M
authors.lastname: Sodhi
authors.forename: K P
authors.initials: KP
authors.lastname: Lesch
authors.forename: J F
authors.initials: JF
authors.lastname: Meyer
authors.forename: P
authors.initials: P
authors.lastname: Sham
authors.forename: D A
authors.initials: DA
authors.lastname: Collier
authors.forename: R M
authors.initials: RM
authors.lastname: Murray
authors.forename: R W
authors.initials: RW
authors.lastname: Kerwin
mesh_terms: D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics*; D012680:Sensitivity and Specificity
chemical_list: D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; D003024:Clozapine