[Metabolism of heme and hemoproteins in rat liver upon administration of mercuric chloride].
Rat liver delta-aminolevulinate synthase (delta-ALAS) activity in the early period after mercury chloride administration (0.7 mg per 100 g body weight) was found to be followed by free heme level increase, which was registered by the increase of heme saturation of the heme-binding protein tryptophan-2,3-dioxygenase (T-2,3-DO). delta-ALAS and heme oxygenase activity increase was observed 24 h after action. Microsomal cytochromes P450 and b5 levels decrease. Heme saturation of the T-2,3-DO returned to control level. Heme oxygenase and T-2,3-DO induction promoted hepatocytes free heme level normalization. Heme oxygenase and delta-ALAS induction role in the liver cells defense from the oxidative damage is discussed.
Kaliman
P A
PA
Kharkovsky State University, Ukraine.
Nikitchenko
I V
IV
Barannik
T V
TV
Sokol
O A
OA
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D006420:Hemeproteins / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014366:Tryptophan Oxygenase / Q000378:metabolism
D006420:Hemeproteins; D006418:Heme; D008627:Mercuric Chloride; D014366:Tryptophan Oxygenase; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase; D005978:Glutathione