title: Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices.
abstract: A material has been developed and tested that permanently records thermal response patterns from heating devices. The material consists of a mixture of polyacrylamide and 18% w/w bovine serum albumin. Thermal denaturation is complete when the local temperature exceeds 70 degrees C, causing a large reduction in the T2 of the material. Three-dimensional distributions of "thermal damage" can be assessed using standard magnetic resonance imaging sequences. The material works well with microwave heating devices and is adaptable for use with ultrasound, radio-frequency, or laser heating devices. Suggested uses include characterizing heating devices prior to treatment and developing new clinical applications for thermal therapies.
authors.affiliation: Sunnybrook & Women's College Health Sciences Centre and Department of Medical Biophysics, University of Toronto, Ontario, Canada.
authors.forename: L S
authors.initials: LS
authors.lastname: Bouchard
authors.forename: M J
authors.initials: MJ
authors.lastname: Bronskill
mesh_terms: D000180:Acrylic Resins; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D002417:Cattle; D005782:Gels; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation* / Q000379:methods; D008279:Magnetic Resonance Imaging; D008872:Microwaves / Q000627:therapeutic use; D019047:Phantoms, Imaging; D012710:Serum Albumin, Bovine; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D005782:Gels; D012710:Serum Albumin, Bovine; D000099166:Polyacrylamides