The role of free radical reactions with haemoglobin and thalassaemia.
It is well known that all living systems depend on iron to transport (haemoglobin), store (myoglobin) and utilize (cytochromes, cytochrome oxide) oxygen for respiration. Iron is an essential component in the active sites of the enzyme that protects against oxidation, such as the iron superoxide dismutase, in bacteria and plants. In normal human plasma almost all iron loading of transferrin is 20-30% maximum. In this presentation we review and summarize recent developments in our understanding of iron transport and storage in living systems.
Anastassopoulou
J
J
National Technical University of Athens, Chemical Engineering Department, Greece.
Anifantakis
B
B
Anifantakis
Z A
ZA
Dovas
A
A
Theophanides
T
T
D005609:Free Radicals / Q000737:chemistry / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use; D010108:Oxyhemoglobins / Q000737:chemistry / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013789:Thalassemia / Q000097:blood* / Q000188:drug therapy
D005609:Free Radicals; D006454:Hemoglobins; D007502:Iron Chelating Agents; D010108:Oxyhemoglobins; D013482:Superoxide Dismutase