Strategies in complex disease mapping.
Dissecting the genetics of common, complex disorders remains one of the great challenges in human genetics. The acceleration of human genome sequence determination, improvements in informatics, large-scale identification of single nucleotide polymorphisms and improvements in scoring technologies have now increased the feasibility of identifying polymorphisms that predispose to common disease.
Johnson
G C
GC
Department of Medical Genetics, Wellcome Trust/MRC Building, University of Cambridge, Wellcome Trust Centre for Molecular Mechanisms of Disease, Addenbrookes Hospital, Cambridge, CB2 2XY, UK.
Todd
J A
JA
D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D005826:Genetics, Medical / Q000379:methods; D015894:Genome, Human; D006801:Humans; D011110:Polymorphism, Genetic