title: Regulation of sulfate transport and synthesis of sulfur-containing amino acids.
abstract: Recent research indicates that several sulfate transporters - exhibiting different tissue specificities and modes of expression - may play distinct roles in sulfate uptake within specific tissues and in long-distance sulfate translocation. The transcription levels of particular genes and feedback inhibition of serine acetyltransferase play major roles in regulating sulfur assimilation and cysteine synthesis. O-acetylserine and glutathione presumably act within the cysteine synthesis pathway as derepressor and repressor, respectively. A unique autoregulatory mechanism that stabilizes mRNA levels has recently been proposed for the regulation of methionine synthesis.
authors.affiliation: Laboratory of Molecular Biology and Biotechnology, Faculty of Pharmaceutical Sciences, Research Center of Medicinal Resources, Chiba University, Inage-ku, 263-8522, Japan. ksaito@p.chiba-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Saito
mesh_terms: D001692:Biological Transport; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003545:Cysteine / Q000096:biosynthesis*; D018506:Gene Expression Regulation, Plant; D026901:Membrane Transport Proteins; D008715:Methionine / Q000096:biosynthesis*; D008954:Models, Biological; D012694:Serine / Q000031:analogs & derivatives / Q000502:physiology; D015398:Signal Transduction; D000076988:Sulfate Transporters; D013431:Sulfates / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters; D013431:Sulfates; D012694:Serine; D008715:Methionine; C043943:O-acetylserine; D003545:Cysteine