The genetics of Parkinson's disease.
The effort to map the entire human genome has led recently to the important milestone publication in late 1999 of the complete sequence of chromosome 22. This has been facilitated by increasingly sophisticated tools for genetic analysis and the ensuing wealth of detailed genetic information. The quest for genetic factors contributing to Parkinson's disease and parkinsonian disorders has revealed a progressively complex picture implicating gene mutations in the rarer, autosomally inherited forms of Parkinson's disease and the interplay of genetic and/or environmental factors in the common sporadic forms of the disorder. These findings not only reiterate the complex genetic heterogeneity of Parkinson's disease but could also point towards common pathogenic mechanisms in Parkinson's disease and related neurodegenerative disorders.
de Silva
H R
HR
Reta Lila Weston Institute of Neurological Studies, Royal Free and University College Medical School, London, W1P 6DB, UK. rsilva@ion. ucl.ac.uk
Khan
N L
NL
Wood
N W
NW
D000818:Animals; D002874:Chromosome Mapping; D002892:Chromosomes, Human, Pair 22; D006801:Humans; D008025:Ligases; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D051843:Synucleins; D013869:Thiolester Hydrolases / Q000235:genetics; D043222:Ubiquitin Thiolesterase; D044767:Ubiquitin-Protein Ligases
D009419:Nerve Tissue Proteins; D011506:Proteins; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase; D008025:Ligases