title: The risk of contrast media-induced ventricular fibrillation is low in canine coronary arteriography with ioxilan.
abstract: Previous studies have proposed that sodium supplement to nonionic contrast media (CM) can decrease the risk of ventricular fibrillation (VF). This study was designed to compare the occurence of VF induced by ioxilan (containing 9 mmol/LNa+) with other nonionic CMs. After wedging a catheter in the right coronary artery, test solutions including ioxilan, ioversol, iomeprol, and iopromide were infused for 30 sec at the rate of 0.4 ml/sec or until VF occurred. Then, incidence of VF, contact time (i.e. the time required to produce VF), and QTc were measured. Also, the CMs other than ioxilan were investigated at sodium levels adjusted to 9 and 20 mmol/L Na+. The incidence of VF with ioxilan (0%) was the lowest of all. In the other CMs, the incidence decreased in accordance with increase of sodium. Iomeprol and iopromide showed significant reduction of VF incidence at the sodium level of 20 mmol/L. The higher sodium supplements also prolonged the contact times. The increase of QTc was the greatest in ioxilan. Ioxilan has the least arrythmogenic property among the current low-osmolality nonionic CMs. This property might be attributable to an optimal sodium concentration of 9 mmol/L in the CM.
authors.affiliation: Department of Veterinary Medicine, Kagoshima University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Misumi
authors.forename: O
authors.initials: O
authors.lastname: Tateno
authors.forename: M
authors.initials: M
authors.lastname: Fujiki
authors.forename: N
authors.initials: N
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007479:Iopamidol / Q000009:adverse effects / Q000031:analogs & derivatives; D008297:Male; D009994:Osmolar Concentration; D014283:Triiodobenzoic Acids / Q000009:adverse effects; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; C057937:iomeprol; D007472:Iohexol; C038192:iopromide; C055357:ioxilan; D007479:Iopamidol; C054871:ioversol