Novel cytotoxic diterpenes from Casearia arborea.
Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.
Beutler
J A
JA
Laboratory of Drug Discovery Research & Development, Developmental Therapeutics Program, Division of Cancer Treatment & Diagnosis, National Cancer Institute-FCRDC, Bldg. 1052, Rm. 121, Frederick, Maryland 21702-1201, USA.
McCall
K L
KL
Herbert
K
K
Herald
D L
DL
Pettit
G R
GR
Johnson
T
T
Shoemaker
R H
RH
Boyd
M R
MR
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes