title: Risk factors for depression in later life; results of a prospective community based study (AMSTEL).
abstract: BACKGROUND
  Depression in the elderly was found to be associated with a variety of risk-factors in cross sectional designs. Based on the vulnerability-stress model, etiologic pathways for depression have been suggested, with vulnerability modifying the effect of stress factors. The current prospective study tests an etiologic model for depression incidence, by assessing modifying effects of three types of vulnerability: genetic/familial vulnerability, organic vulnerability, and environmental vulnerability.
  
  
  METHODS
  1940 non-depressed community-living elderly were interviewed at baseline, and at follow-up three years later. Bivariate and multivariate relationships between risk factors and incident depression (GMS-AGECAT) were studied.
  
  
  RESULTS
  Higher age, personal history of depression, death of spouse, health related factors and comorbid organic or anxiety syndrome showed significant bivariate associations with depression incidence. In multivariate analysis, the effect of stress factors on incident depression was not modified by a genetic/familial vulnerability, nor by an organic vulnerability. Effect modification by environmental factors was however evident; having a marital partner, and if unmarried having social support, significantly reduced the impact of functional disabilities on the incidence of depression.
  
  
  CONCLUSIONS
  The study consisted of two measurements with a three years interval, depressive episodes with a short duration may be under-represented.
  
  
  CONCLUSIONS
  In the elderly, the effect of stress on incident depression is modified by environmental vulnerability. No evidence was found of effect modification by either genetic/familial or organic vulnerability. The results have implications for both recognition and treatment of late-life depression.
authors.affiliation: Department of Psychiatry, Vrije Universiteit Amsterdam, Valeriusplein 9, 1075 BG, Amsterdam, The Netherlands. RA.Schoevers@SCW.VU.nl
authors.forename: R A
authors.initials: RA
authors.lastname: Schoevers
authors.forename: A T
authors.initials: AT
authors.lastname: Beekman
authors.forename: D J
authors.initials: DJ
authors.lastname: Deeg
authors.forename: M I
authors.initials: MI
authors.lastname: Geerlings
authors.forename: C
authors.initials: C
authors.lastname: Jonker
authors.forename: W
authors.initials: W
authors.lastname: Van Tilburg
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015986:Confounding Factors, Epidemiologic; D003863:Depression / Q000453:epidemiology* / Q000209:etiology* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008016:Life Change Events; D008297:Male; D008960:Models, Psychological; D009426:Netherlands / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D012944:Social Support; D013315:Stress, Psychological / Q000523:psychology*; D011795:Surveys and Questionnaires