title: A biodegradable multiblock co-polymer derived from an alpha, omega-bis(methylamino)peptide and an alpha, omega-bis(oxiranylmethyl)poly(ethylene glycol).
abstract: A novel peptide containing the lysosomally degradable sequence GlyPheLeuGly and a sequence-inverting unit has been prepared. This peptide presents the methylamino groups of sarcosine (N-methylglycine) at both termini for co-polymerisation with alpha, omega-bis(oxiranylmethoxy)poly(ethylene glycol) of mean M(w) 1650. Gel permeation chromatographic analysis showed the presence of a mixture of oligomers. Preliminary degradation studies showed that these oligomers are cleaved by cathepsin B, an important lysosomal enzyme.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, BA2 7AY, Bath, UK.
authors.forename: S E
authors.initials: SE
authors.lastname: Matthews1
authors.forename: C W
authors.initials: CW
authors.lastname: Pouton
authors.forename: M D
authors.initials: MD
authors.lastname: Threadgill
mesh_terms: D002401:Cathepsin B / Q000737:chemistry; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D010455:Peptides / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; C413050:alpha,omega-bis(oxiranylmethoxy)poly(ethylene glycol); C413051:poly(sarcoyl-glycyl-phenylalanyl-leucyl-glycyl-aminoethylaminocarbonylmethyl(N-methyl)amino-co-alpha,omega-bis(oxiranylmethyl)poly(ethylene glycol)); D011092:Polyethylene Glycols; D002401:Cathepsin B