Hepatosplenic cat-scratch disease in children: selected clinical features and treatment.
We reviewed 19 cases of hepatosplenic cat-scratch disease at Texas Children's Hospital (Houston). The range of the patients' ages was 2 years 4 months to 11 years 8 months. The chief complaint was fever for all patients. The duration of fever before diagnosis was 7 to 56 days (mean, 22 days). Abdominal pain was present in 13 patients (68%). Thirteen children were treated with rifampin alone, and three received rifampin therapy plus gentamicin or trimethoprim-sulfamethoxazole. Once rifampin therapy was initiated alone or in combination, improvement was noted within 1 to 5 days (mean, 2.6 days) for patients who had had prolonged fever the duration of which before rifampin therapy averaged 3 weeks. The most common dosage and duration for our patients were 20 mg/[kg x d] every 12 hours and 14 days, respectively. Rifampin should be considered in the initial antimicrobial treatment of hepatosplenic cat-scratch disease.
Arisoy
E S
ES
Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, USA.
Correa
A G
AG
Wagner
M L
ML
Kaplan
S L
SL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002372:Cat-Scratch Disease / Q000188:drug therapy / Q000503:physiopathology; D002415:Cats; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy / Q000503:physiopathology; D012293:Rifampin / Q000627:therapeutic use; D013158:Splenic Diseases / Q000188:drug therapy / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D012293:Rifampin