Absence of cocaine-induced place conditioning in serotonin 1B receptor knock-out mice.
A large body of evidence suggests that genetic factors may affect the reinforcing properties of drugs of abuse. This study investigated the involvement of the serotonin 1B (5-HT1B) receptor in modulating cocaine-induced place conditioning by comparing the response of 5-HT1B receptor gene knock-out mice with wild type 129/Sv-ter mice. The rewarding effects of various doses of cocaine (0, 2.5, 5, 10, 20, and 40 mg/kg) were examined in both strains. Results clearly show that 5-HT1B receptor knock-out mice failed to display a conditioned place preference for stimuli paired with cocaine while wild type mice exhibited a conditioned place preference for the compartment paired with cocaine (5 and 20 mg/kg). As other studies showed that 5-HT1B knock-out mice self-administer cocaine, these results suggest a dissociation between the psychologic state linked to self-administration and the one measured in conditioned place preference.
Belzung
C
C
LEPCO, UFR Sciences et Techniques, Parc Grandmont, F-37200 TOURS, France. belzung@univ-tours.fr
Scearce-Levie
K
K
Barreau
S
S
Hen
R
R
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000235:genetics / Q000502:physiology*
D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D003042:Cocaine