title: Outcomes of extremely low-birth-weight infants between 500 and 750 g.
abstract: OBJECTIVE
  The purpose of this study was to describe morbidity, mortality, and developmental outcomes among extremely low-birth-weight infants (500-750 g).
  
  
  METHODS
  This retrospective cohort study included 167 live-born infants born at Long Beach Memorial Medical Center between January 1990 and December 1995.
  
  
  RESULTS
  Mortality rates were 86% among infants <600 g and 44% among those > or =600 g, and the rate decreased with increasing gestational age. The absence of chorioamnionitis (P =.01) and the use of antepartum corticosteroids (P <.0001) or neonatal surfactant (P =.0001) were associated with survival. Sixty-four percent of studied infants had respiratory distress syndrome, and 17% had grade III or IV intraventricular hemorrhage. Among the 63 survivors 57% were tested at 30 months of corrected age with the Bayley Scales of Infant Development. Mild or significant delays were seen on the mental development index in 68% of these cases and on the psychomotor development index in 58% of cases.
  
  
  CONCLUSIONS
  Morbidity and mortality rates and the rate of developmental delay among infants with birth weights between 500 and 750 g were significant.
authors.affiliation: Department of Obstetrics and Gynecology, Perinatal Associates, Long Beach Memorial Medical Center, CA 90801, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Agustines
authors.forename: Y G
authors.initials: YG
authors.lastname: Lin
authors.forename: P J
authors.initials: PJ
authors.lastname: Rumney
authors.forename: M C
authors.initials: MC
authors.lastname: Lu
authors.forename: R
authors.initials: R
authors.lastname: Bonebrake
authors.forename: T
authors.initials: T
authors.lastname: Asrat
authors.forename: M
authors.initials: M
authors.lastname: Nageotte
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000628:therapy; D002821:Chorioamnionitis / Q000150:complications; D015331:Cohort Studies; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D005865:Gestational Age; D006801:Humans; D007226:Infant Mortality; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007752:Obstetric Labor, Premature / Q000150:complications; D011247:Pregnancy; D011379:Prognosis; D011597:Psychomotor Performance; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012127:Respiratory Distress Syndrome, Newborn / Q000453:epidemiology / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D011663:Pulmonary Surfactants