[Ways to improve ocular bioavailability for topical applications].
The anatomical, physiological and pharmacological properties of the eye explain the short pre-corneal residence time and the poor bioavailability of most eye-drop solutions. Many approaches have been proposed to increase ocular bioavailability of drugs. Most eye-drops include a viscosity agent in their formulation to significantly prolong residence time although the increased viscosity is limited due to patient discomfort. More recent developments include biodegradable inserts, eye-drop based on cyclodextrins, liposomes or nanoparticles.
Sirbat
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Cabinet d'Ophtalmologie, 15 rue du Dôme, F-67000 Strasbourg.
Marchal-Heussler
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L
Hoffman
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M
Maincent
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P
D001682:Biological Availability; D005123:Eye / Q000378:metabolism*; D006801:Humans; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics*; D011355:Prodrugs / Q000493:pharmacokinetics
D009883:Ophthalmic Solutions; D011355:Prodrugs