[Anti-osteolytic therapy preserves trabecular structure and mechanical properties of bone in tumor osteolysis].
OBJECTIVE
Little is known about the effect of a tumor on the trabecular architecture, therefore we employed an animal model for the assessment of bone quality in tumor osteolysis to determine the alterations of the trabecular architecture in tumor osteolysis and after an interventional treatment with a bisphosphonate.


METHODS
To assess the bone mass and the micro-architecture of the trabecular bone in tumor osteolysis we employed a micro-computed tomography system. For the assessment of the mechanical properties of the treated and non-treated tumor-bearing bones we used a torsion test.


RESULTS
The presence of a tumor in bone resulted in a reduction of bone mass, stability and architectural parameters. An interventional treatment of the animals with a bisphosphonate increased the bone mineral content, mechanical and architectural parameters compared to the non-treated, tumor-bearing animals.


CONCLUSIONS
These results clearly show a beneficial effect of an anti-osteolytic treatment with a bisphosphonate in regard of bone quality in tumor-induced osteolysis.
Kurth
A A
AA
Orthopädische Universitätsklinik Stiftung Friedrichsheim, Frankfurt/Main. A.Kurth@em.uni-frankfurt.de
Kim
S Z
SZ
Bauss
F
F
Müller
R
R
Hovy
L
L
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001859:Bone Neoplasms / Q000473:pathology* / Q000556:secondary; D001862:Bone Resorption / Q000473:pathology; D001842:Bone and Bones / Q000187:drug effects*; D002279:Carcinoma 256, Walker / Q000473:pathology; D004164:Diphosphonates / Q000494:pharmacology*; D004195:Disease Models, Animal; D006801:Humans; D000077557:Ibandronic Acid; D009368:Neoplasm Transplantation; D010014:Osteolysis / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004164:Diphosphonates; D000077557:Ibandronic Acid