[The influence of "rigidity" and structure of fibrous dust on their biological activity].
The authors represent experimental data on cytotoxic, fibrogenic and mutagenic effects of fibrous dusts--"soft" pulp fibers and "stiff" ones (chrysotile-asbestos, carbon, basalt and fiber glass) in comparison with the nonfibrous analogs (antigorit, quartz DQ-12 and others). Viability of peritoneal macrophages was depressed more dramatically by "stiff" fibers vs. the "soft" ones. Mutagenic activity was associated with the "stiffness" degree of the dust particles. When compared to fibrous chemical dusts, nonfibrous ones appeared inert in micronuclear test.
Troitskaia
N A
NA
Velichkovskiĭ
B T
BT
Vanchugova
N N
NN
D000818:Animals; D001194:Asbestos / Q000493:pharmacokinetics; D002244:Carbon / Q000493:pharmacokinetics; D002482:Cellulose / Q000493:pharmacokinetics; D004391:Dust / Q000009:adverse effects*; D005260:Female; D008168:Lung / Q000378:metabolism; D008264:Macrophages / Q000502:physiology; D008903:Minerals / Q000493:pharmacokinetics; D016296:Mutagenesis; D011009:Pneumoconiosis / Q000209:etiology; D051381:Rats; D017640:Silicates / Q000493:pharmacokinetics
D004391:Dust; D008903:Minerals; D017640:Silicates; C060346:basalt; D001194:Asbestos; D002244:Carbon; D002482:Cellulose