Redox methods validation of paracetamol and ascorbic acid in pharmaceutical preparations.
The contents of active substances were determined in a preparation TP-4 (tablets) containing paracetamol, ascorbic acid, caffeine and phenylephrine hydrochloride. For the determination of paracetamol and ascorbic acid a non-specific (cerometric and titration of 2,6-dichloroindophenol) method based on a redox reaction was used. Validation of the methods, performed on model mixtures, proved those methods to be accurate, precise, reproducible and linear within the range from 50% to 150% of the amount declared in the preparation. The content of paracetamol and ascorbic acid in TP-4, Thompayrin, Panadol Extra, Ring N, Polopiryna C, Efferalgan Vitamin C and Vitaminum C 0.2 satisfies the FP V demands (+/- 10% of the declared amount).
Muszalska
I
I
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Zajac
M
M
Wróbel
G
G
Nogowska
M
M
D015086:2,6-Dichloroindophenol; D000082:Acetaminophen / Q000032:analysis*; D018712:Analgesics, Non-Narcotic / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis*; D002110:Caffeine; D004338:Drug Combinations; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D010656:Phenylephrine; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017186:Titrimetry
D018712:Analgesics, Non-Narcotic; D004338:Drug Combinations; D007202:Indicators and Reagents; D010656:Phenylephrine; D000082:Acetaminophen; D002110:Caffeine; D015086:2,6-Dichloroindophenol; D001205:Ascorbic Acid