title: Adult T-cell leukemia successfully treated with allogeneic bone marrow transplantation.
abstract: Adult T-cell leukemia (ATL) is associated with human T-cell leukemia virus type 1 (HTLV-1) and is known to be a refractory disease of highly poor prognosis. We describe a case of ATL treated with allogeneic bone marrow transplantation (allo-BMT). The allo-BMT successfully induced complete remission in the patient. Currently, at 24 months post BMT, there has been no evidence of minimal residual disease (MRD) detected by polymerase chain reaction (PCR) assay for the T-cell receptor gamma chain gene. By contrast, PCR analysis demonstrated the reappearance of the cells harboring the integrations of the HTLV-1 proviral DNA 9 months after the BMT. These findings may imply a reversion to the carrier state rather than the recurrence of the leukemia from the MRD. The clinical consequence of our case illustrates that allo-BMT is an effective therapy, at least for achieving longer disease-free survival in ATL.
authors.affiliation: First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tajima
authors.forename: R
authors.initials: R
authors.lastname: Amakawa
authors.forename: K
authors.initials: K
authors.lastname: Uehira
authors.forename: N
authors.initials: N
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: Y
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: S
authors.initials: S
authors.lastname: Fukuhara
mesh_terms: D016026:Bone Marrow Transplantation; D004279:DNA, Viral; D018572:Disease-Free Survival; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007564:Japan; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000628:therapy* / Q000821:virology; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000175:diagnosis; D016133:Polymerase Chain Reaction; D014184:Transplantation, Homologous
chemical_list: D004279:DNA, Viral