title: The combined occurrence of macular amyloidosis and prurigo nodularis.
abstract: The association of prurigo nodularis (PN) and macular amyloidosis (MA) has not been reported before. Although pruritus related frictional trauma is a well-known cause of PN, its role in the development of MA has always been questioned. We herein report two cases with chronic liver disease and iron deficiency who concomitantly developed MA and PN lesions. Pruritus was the preceding factor and both lesions were confined to scratched areas. The association of two otherwise uncommon dermatoses in pruritic patients and their characteristic distribution might indicate an important role for pruritus-induced scratching in the pathogenesis of MA, too.
authors.affiliation: Department of Dermatology, Istanbul Medical Faculty, Istanbul University, 34390 Istanbul, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Baykal
authors.forename: E
authors.initials: E
authors.lastname: Ozkaya-Bayazit
authors.forename: G
authors.initials: G
authors.lastname: Gökdemir
authors.forename: R
authors.initials: R
authors.lastname: Diz Küçükkaya
mesh_terms: D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018798:Anemia, Iron-Deficiency / Q000150:complications*; D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006521:Hepatitis, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011537:Pruritus / Q000209:etiology* / Q000473:pathology; D012867:Skin / Q000378:metabolism / Q000473:pathology*
chemical_list: D000682:Amyloid