title: [Effect of chronic low-dose irradiation and etoposide on the life spain of Drosophila melanogaster strain mei-41].
abstract: Longevity is a temporal characteristic dependent on the level of equilibrium between the damaging and restorative processes in an organism. This is a complex parameter determined by both genotypic and external factors. In experiments with the mutant strain of Drosophila melanogaster mei-41D5, it was demonstrated that chronic exposure to low-dose radiation can change the longevity of flies. A decrease in the longevity of both males and homo- and heterozygous females of this strain was also caused by specific inducers of apoptosis. We suggest that apoptosis plays a certain role in the aging of an organism and that the dominant gene mei-41D5 takes part in determining longevity in Drosophila.
authors.affiliation: Institute of Biology, Komi Research Center, Russian Academy of Sciences, Komi Republic, Russia.
authors.forename: V G
authors.initials: VG
authors.lastname: Zaĭnullin
authors.forename: A A
authors.initials: AA
authors.lastname: Moskalev
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects*; D005047:Etoposide / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects* / Q000528:radiation effects*; D009154:Mutation; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology*; D011829:Radiation Dosage
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D005047:Etoposide