title: A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
abstract: The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal.
authors.affiliation: Volgograd Medical Academy, Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: G K
authors.initials: GK
authors.lastname: Wikman
authors.forename: V B
authors.initials: VB
authors.lastname: Mandrikov
authors.forename: I A
authors.initials: IA
authors.lastname: Mironova
authors.forename: V V
authors.initials: VV
authors.lastname: Neumoin
mesh_terms: D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004521:Educational Measurement; D004644:Emotions; D005221:Fatigue / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007194:India / Q000208:ethnology; D018782:Maze Learning / Q000187:drug effects; D008517:Phytotherapy; D010865:Pilot Projects; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000627:therapeutic use*; D011597:Psychomotor Performance / Q000187:drug effects; D011674:Pulse; D013315:Stress, Psychological / Q000503:physiopathology*; D013337:Students, Medical; D013548:Sweden
chemical_list: D010936:Plant Extracts