Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity.
Masters
J J
JJ
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. jjm@lilly.com
Franciskovich
J B
JB
Tinsley
J M
JM
Campbell
C
C
Campbell
J B
JB
Craft
T J
TJ
Froelich
L L
LL
Gifford-Moore
D S
DS
Hay
L A
LA
Herron
D K
DK
Klimkowski
V J
VJ
Kurz
K D
KD
Metz
J T
JT
Ratz
A M
AM
Shuman
R T
RT
Smith
G F
GF
Smith
T
T
Towner
R D
RD
Wiley
M R
MR
Wilson
A
A
Yee
Y K
YK
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001549:Benzamides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001555:Benzene Derivatives / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D015951:Factor Xa / Q000378:metabolism; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D010880:Piperidines / Q000737:chemistry; D011817:Rabbits; D013329:Structure-Activity Relationship; D013927:Thrombosis / Q000517:prevention & control
D000925:Anticoagulants; D001549:Benzamides; D001555:Benzene Derivatives; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D010880:Piperidines; D015951:Factor Xa