Antibody response after influenza vaccination in HIV-infected individuals: a consecutive 3-year study.
In a consecutive 3-year study the antibody response after immunization with influenza vaccine of a cohort of HIV-infected adults was studied. The haemagglutination-inhibiting (HAI) antibody titres after vaccination correlated with the number of CD4(+) T lymphocytes (p<0.001), the prevaccination antibody titres (p<0.001), and the proliferative response to anti-CD3 (p<0.001). Severely impaired antibody responses were observed in HIV-infected individuals with CD4(+) T-lymphocyte counts < or =100x10(6)/l. Significantly higher prevaccination antibody titres were observed in healthy controls in the 2nd or 3rd year of vaccination, but not in HIV-infected individuals. Annually repeated vaccination of HIV-infected individuals did not lead to higher postvaccination antibody titres. Annual vaccination of HIV-infected individuals with CD4(+) T-lymphocyte counts exceeding 100x10(6)/l seems to be worthwhile, although it may not be expected to render the same level of protection against influenza as in non-infected individuals.
Kroon
F P
FP
Department of Infectious Diseases, Leiden University Medical Center, C5P, PO Box 9600, 2300 Leiden, The Netherlands. kroonfp@xs4all.nl
van Dissel
J T
JT
de Jong
J C
JC
Zwinderman
K
K
van Furth
R
R
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D011446:Prospective Studies; D013997:Time Factors; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines