Immunohistochemistry for parathyroid hormone-related protein (PTHrP) in benign and malignant mammary mixed tumors of dogs with and without hypercalcemia.
We evaluated the expression of parathyroid hormone-related protein (PTHrP) by immunohistochemistry in eight benign and malignant mammary mixed tumors of dogs with (n = 4) and without (n = 4) hypercalcemia. Positive immunoreactive staining for PTHrP was observed in all four tumors from hypercalcemic dogs. The mammary tumors from 2 of the 4 normocalcemic dogs stained positively for PTHrP, but the numbers of immunoreactive cells and intensity of the immunoreaction were less than in the hypercalcemic dogs. In the other 2 tumors without hypercalcemia, the tissue samples were negative for PTHrP.
Konno
A
A
Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. akonno@vetmed.hokudai.ac.jp
Sukegawa
A
A
Kusano
M
M
Kariya
K
K
Ishida
T
T
Okada
H
H
D000818:Animals; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006934:Hypercalcemia / Q000150:complications*; D007150:Immunohistochemistry; D015674:Mammary Neoplasms, Animal / Q000737:chemistry* / Q000150:complications; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*
D044162:Parathyroid Hormone-Related Protein; D011506:Proteins