[Autocrine stimulation of cell proliferation in colonic carcinoma: a biological curiosity or a new therapeutic target?].
Chemotherapy has little efficacy in the treatment of advanced colorectal carcinoma. Biological investigation has made evident several autocrine stimulation loops; the best documented one involves epidermal growth factor (EGF): this growth factor stimulates cell proliferation and cell secretion of proteolytic enzymes. Suramin and somatostatin are able to disrupt these loops of stimulation. Clinical studies performed with octreotide, a somatostatin analogue, and suramin have been unsuccessful until now.
Rodier
J M
JM
Service de médecine interne et d'oncologie médicale (Pr Bernadou), hôpital de l'Hôtel-Dieu, Paris, France.
Pujade-Lauraine
E
E
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002455:Cell Division / Q000502:physiology*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D004815:Epidermal Growth Factor / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000502:physiology; D013004:Somatostatin / Q000627:therapeutic use; D013498:Suramin / Q000627:therapeutic use; D016211:Transforming Growth Factor alpha / Q000502:physiology*; D014407:Tumor Cells, Cultured / Q000378:metabolism / Q000473:pathology
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D016211:Transforming Growth Factor alpha; D013004:Somatostatin; D013498:Suramin; D004815:Epidermal Growth Factor