title: Assessment of left ventricular function by gated myocardial perfusion and gated blood-pool SPECT: can we use the same reference database?
abstract: The purpose of this study was to compare left ventricular (LV) volume and ejection fraction (LVEF) measurements obtained with electrocardiographic gated single-photon emission computed tomographic (SPECT) myocardial perfusion imaging (GS-MPI) with those obtained with gated SPECT cardiac blood-pool imaging (GS-pool). Fifteen patients underwent GS-MPI with technetium-99m-tetrofosmin and GS-pool with technetium-99m-erythrocyte, within a mean interval of 8 +/- 3 days. Eight patients had suspected dilated cardiomyopathy and seven patients had angiographically significant coronary artery disease. End-diastolic volume (EDV), end-systolic volume (ESV) and LVEF measurements were estimated from GS-MPI images by means of Cedars-Sinai automatic quantitative program and from GS-pool images by the threshold technique. Mean differences between GS-MPI and GS-pool in EDV, ESV and LVEF measurements were -2.8 +/- 10.5 ml [95% confidence interval (CI): -8.6 +/- 3.0 ml], 2.6 +/- 7.3 ml (CI: -1.4 +/- 6.6 ml) and -2.3 +/- 5.1% (CI: -5.1 +/- 0.6%), respectively. No significant difference in the mean differences from 0 was found for EDV, ESV or LVEF measurements. Bland-Altman plots revealed no trend over the measured LV volumes and LVEF. For all parameters, regression lines approximated lines of identity. The excellent agreement between GS-MPI and GS-pool measurements suggests that, for estimation of LV volumes and LVEF, these two techniques may be used interchangeably and measurements by one method can serve as a reference for the other.
authors.affiliation: Division of Tracer Kinetics, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Japan.
authors.forename: A K
authors.initials: AK
authors.lastname: Paul
authors.forename: S
authors.initials: S
authors.lastname: Hasegawa
authors.forename: J
authors.initials: J
authors.lastname: Yoshioka
authors.forename: H
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: E
authors.initials: E
authors.lastname: Tsujimura
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging; D003327:Coronary Disease / Q000000981:diagnostic imaging; D016208:Databases, Factual; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D012016:Reference Values; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods* / Q000592:standards / Q000706:statistics & numerical data; D016277:Ventricular Function, Left
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin; D013667:Technetium