Synthesis of the proposed structure of fudecalone, an anticoccidial drimane terpenoid.
[formula: see text] The proposed structure of fudecalone (1), an anticoccidial drimane sesquiterpene, was synthesized as a racemate in six steps starting from a known phthalide (5). Interestingly, our synthetic 1 showed conformation 1b, while the natural one was reported as 1a, and the NMR spectral data were not identical.
Watanabe
H
H
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan.
Furuuchi
T
T
Yamaguchi
T
T
Kitahara
T
T
D003049:Coccidiostats / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
D003049:Coccidiostats; D009281:Naphthalenes; C092178:fudecalone