[Epileptogenesis of acute encephalitis and acute encephalopathy: epilepsy with its onset in the acute phase and without a latent period].
Epileptogenesis was evaluated in 60 patients with acute encephalitis and in 10 patients with acute encephalopathy. Forty-seven patients have been seizure-free during for more than three years' follow-up (Group III). On the other hand, 23 patients developed epilepsy. Among them, 18 patients developed epilepsy after a latent period of 1 month to 2 3/12 years (Group I). In Group I, a younger age of the onset, a long period of disturbed consciousness and a high activity of CSF neuron-specific enolase (NSE) was associated with refractory epilepsy. The other five patients had continuous seizures from the acute phase of encephalitis without a latent period (Group II). They had more than 2 types of partial motor seizures which occurred frequently during the acute phase of encephalitis. The NSE activity in the CSF of patients in Group II was less than 50 ng/ml, being similar to those in Group III. The epilepsy in Group II, however, was the most refractory. The reason for the development of this continuous refractory epilepsy remained obscure.
Nara
T
T
Division of Neurology, Saitama Children's Medical Center.
Hamano
S
S
Nozaki
H
H
Tanaka
Y
Y
Shimizu
M
M
Noda
Y
Y
Atsukawa
K
K
Arita
J
J
Horita
H
H
Maekawa
K
K
D000208:Acute Disease; D000210:Acute-Phase Reaction; D000367:Age Factors; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001927:Brain Diseases / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004660:Encephalitis / Q000150:complications* / Q000473:pathology; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D011379:Prognosis; D013997:Time Factors
D015415:Biomarkers; D010751:Phosphopyruvate Hydratase