title: Eicosanoid regulation of angiogenesis in human prostate carcinoma and its therapeutic implications.
abstract: Cancer of the prostate is the most commonly diagnosed cancer in America. There are several lines of evidence implicating the involvement of arachidonate 12-lipoxygenase, an enzyme metabolizing arachidonic acid to form 12(S)-hydroxyeicosatetraenoic acid (HETE), in prostate cancer progression. First, as prostate cancer reaches a more advanced stage, the level of 12-lipoxygenase expression is increased. Second, overexpression of 12-lipoxygenase in human prostate cancer cells stimulates angiogenesis and tumor growth. Third, an inhibitor of 12-lipoxygenase has been found effective against metastatic prostate tumor growth, and the inhibition of 12-lipoxygenase is related with the reduction of tumor angiogenesis. Collectively, these studies suggest that 12-lipoxygenase regulates tumor angiogenesis in prostate cancer and that inhibition of 12-lipoxygenase is a novel therapeutic approach for the treatment of prostate cancers.
authors.affiliation: Department of Radiation Oncology, Wayne State University, Detroit, Michigan 48202, USA.
authors.forename: D
authors.initials: D
authors.lastname: Nie
authors.forename: K
authors.initials: K
authors.lastname: Tang
authors.forename: K
authors.initials: K
authors.lastname: Szekeres
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: K V
authors.initials: KV
authors.lastname: Honn
mesh_terms: D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / Q000502:physiology; D001092:Arachidonate 12-Lipoxygenase / Q000378:metabolism; D015777:Eicosanoids / Q000502:physiology*; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic; D011471:Prostatic Neoplasms / Q000098:blood supply* / Q000201:enzymology / Q000473:pathology
chemical_list: D015777:Eicosanoids; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D001092:Arachidonate 12-Lipoxygenase