title: Daily rhythms in renal blood flow and urine production rate in the near-term sheep fetus.
abstract: Daily rhythmicity of renal blood flow (RBF) and urine flow (UF) was studied in fetal sheep between 121-125 d of gestation. Fetal arterial blood pressure, heart rate, UF, and right RBF were measured continuously for 24-h periods in 10 sheep. Rhythmic variations during a 24-h period were found for all variables studied. The rhythms of arterial blood pressure and heart rate were highly correlated, whereas an inverse correlation was found between arterial blood pressure with RBF and between arterial blood pressure with UF. These findings indicate that fetal RBF is not blood pressure dependent. Furthermore, fetal UF appears not to be mediated by pressure-dependent diuresis.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Groningen, The Netherlands.
authors.forename: M A
authors.initials: MA
authors.lastname: Braaksma
authors.forename: F M
authors.initials: FM
authors.lastname: Poortinga
authors.forename: J G
authors.initials: JG
authors.lastname: Aarnoudse
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002940:Circadian Rhythm; D004231:Diuresis / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000502:physiology*; D006340:Heart Rate, Fetal; D007668:Kidney / Q000098:blood supply*; D011247:Pregnancy; D012039:Regional Blood Flow; D012756:Sheep / Q000196:embryology*