5-Amino-dU: a nucleoside analogue in the central strand of DNA triplex for orientation selective binding of A/G/C/T in the third strand.
[formula: see text] 5-Amino-dU, a designed nucleoside analogue, when placed in the central strand of DNA triple helix, recognizes all four bases A, G, C, and T in the third strand, with a selectivity based on the orientation (parallel/antiparallel) of the third strand.
Rana
V S
VS
Division of Organic Synthesis, National Chemical Laboratory, Pune, India.
Ganesh
K N
KN
D004247:DNA / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000737:chemistry; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D013056:Spectrophotometry, Ultraviolet
D004268:DNA-Binding Proteins; C410463:5-amino-2'-deoxyuridine; D004247:DNA; D003857:Deoxyuridine