title: [Benign thyroid disease: 20-year experience in surgical therapy].
abstract: This retrospective study compares recurrence and postoperative complication rates after isthmo-lobectomy and subtotal thyroidectomy (group I) vs near-total and total thyroidectomy (group II) for benign thyroid disease. Seven hundred and forty-three patients were operated on for thyroid diseases over the period from 1977 to 1998. We considered 202 patients operated on for benign thyroid disease from 1988 to 1998. The follow-up ranged from 1 to 10 years (mean: 3.4 yrs). One hundred and thirty-two patients (65.3%) were operated on for bilateral nodular goitre, 35 (17.3%) for unilateral nodular goitre, 14 (6.9%) for toxic goitre and 21 (10.4%) for thyroiditis. Over the period 1988-1992, 19 patients underwent isthmo-lobectomy and 71 subtotal thyroidectomy (group I). From 1993 to 1998, 39 patients underwent near-total thyroidectomy and 61 total thyroidectomy (group II). The relapse rate was 14.4% in group I, while there were no recurrences in group II (p = 0.000064). Temporary hypocalcaemia was significantly higher (p = 0.000001) in group II (29%) than in group I (2.2%). Within group II, the rate was significantly higher (p = 0.0013) after total thyroidectomy (37.7%) than after near-total thyroidectomy (15.4%). In our experience, near-total and total thyroidectomy are an appropriate approach for preventing recurrence in patients with benign thyroid disease despite the fact that the risk of temporary hypocalcaemia is higher than after less radical surgery. Near-total thyroidectomy and the exercise of all due care in the surgical technique may help to reduce its incidence.
authors.affiliation: Policlinico Umberto I, II Clinica Chirurgica, Università La Sapienza, Roma.
authors.forename: F
authors.initials: F
authors.lastname: Zaraca
authors.forename: M
authors.initials: M
authors.lastname: Di Paola
authors.forename: F
authors.initials: F
authors.lastname: Gossetti
authors.forename: D
authors.initials: D
authors.lastname: Proposito
authors.forename: P
authors.initials: P
authors.lastname: Filippoussis
authors.forename: L
authors.initials: L
authors.lastname: Montemurro
authors.forename: B
authors.initials: B
authors.lastname: Mancini
authors.forename: S
authors.initials: S
authors.lastname: Gallina
authors.forename: E
authors.initials: E
authors.lastname: Talarico
authors.forename: C
authors.initials: C
authors.lastname: Talarico
authors.forename: M
authors.initials: M
authors.lastname: Lazzaro
authors.forename: G
authors.initials: G
authors.lastname: Mulieri
authors.forename: D
authors.initials: D
authors.lastname: Flati
authors.forename: G
authors.initials: G
authors.lastname: Flati
authors.forename: M
authors.initials: M
authors.lastname: Carboni
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006042:Goiter / Q000601:surgery; D006044:Goiter, Nodular / Q000601:surgery; D006111:Graves Disease / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000601:surgery*; D013965:Thyroidectomy; D013966:Thyroiditis / Q000601:surgery; D013997:Time Factors