title: A simple approach to DOTAP and its analogs bearing different fatty acids.
abstract: A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purified by simple recrystallization.
authors.affiliation: Department of Medicinal Oncology, Tumor Biology Center, Freiburg, Germany. umas@tumorbio.uni-freiburg.de
authors.forename: U
authors.initials: U
authors.lastname: Massing
authors.forename: J T
authors.initials: JT
authors.lastname: Kley
authors.forename: L
authors.initials: L
authors.lastname: Gürtesch
authors.forename: S
authors.initials: S
authors.lastname: Fankhaenel
mesh_terms: D003460:Crystallization; D005227:Fatty Acids / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis* / Q000302:isolation & purification; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000302:isolation & purification; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification
chemical_list: D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005456:Fluorescent Dyes; D008055:Lipids; D000644:Quaternary Ammonium Compounds; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane