Factors associated with periodontitis in an HIV-infected southeast USA study.
OBJECTIVE
To determine the relationship of immunosuppression with measures of probing pocket depth (PPD), recession (REC), and clinical attachment level (CAL) in an HIV-infected population from North Carolina (NC), a state in the southeastern United States (USA).


METHODS
Cross-sectional study of HIV-infected adults (n = 326) treated at the University of North Carolina Hospitals. Clinical medical record review and sociodemographic interview data were collected. Median age of study participants was 37 years (range 19-67). Males comprised 78% and Blacks 60%. Analyses were limited to those who were dentate (n = 316).


METHODS
Main outcomes were cases vs non-cases of notable PPD, REC, and CAL. Immunosuppression measured by CD4+ cell count microL was the exposure of interest.


RESULTS
Defined cases of PPD (n = 148) were 2.6 (95% CI = 1.3, 5.3) times less likely to occur at CD4+ cells < 200 than non-cases, whereas, cases of REC (n = 94) were 2.8 (95% CI = 1.2, 6.6) times more likely to occur at that level of severe immunosuppression, controlling for confounders.


CONCLUSIONS
Sub-groups of persons with HIV experience a high burden of periodontitis where notable severity and extent of PPD, CAL, and REC were clearly evident at different stages of immunosuppression.
McKaig
R G
RG
Department of Dental Ecology, CB#7450 School of Dentistry, University of North Carolina, Chapel Hill, NC, 27599-7450, USA. rosemary.mckaig@unc.edu
Patton
L L
LL
Thomas
J C
JC
Strauss
R P
RP
Slade
G D
GD
Beck
J D
JD
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000328:Adult; D000368:Aged; D044383:Black People; D018791:CD4 Lymphocyte Count; D016009:Chi-Square Distribution; D002908:Chronic Disease; D016001:Confidence Intervals; D015986:Confounding Factors, Epidemiologic; D003430:Cross-Sectional Studies; D005260:Female; D005889:Gingival Recession / Q000276:immunology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D016013:Likelihood Functions; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009657:North Carolina; D017622:Periodontal Attachment Loss / Q000276:immunology; D010514:Periodontal Pocket / Q000276:immunology; D010518:Periodontitis / Q000276:immunology*; D012189:Retrospective Studies; D044465:White People; D001741:Black or African American