title: Gram-scale synthesis of (+)-discodermolide.
abstract: [formula: see text] A triply convergent, highly efficient second-generation synthesis of the potent antimitotic agent (+)-discodermolide (1) has been achieved on a 1-g scale.
authors.affiliation: Department of Chemistry, Monell Chemical Senses Center, University of Pennsylvania 19104, USA. smithab@sas.upenn.edu
authors.forename: A B
authors.initials: AB
authors.lastname: Smith
authors.forename: M D
authors.initials: MD
authors.lastname: Kaufman
authors.forename: T J
authors.initials: TJ
authors.lastname: Beauchamp
authors.forename: M J
authors.initials: MJ
authors.lastname: LaMarche
authors.forename: H
authors.initials: H
authors.lastname: Arimoto
mesh_terms: D000473:Alkanes; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002219:Carbamates; D007202:Indicators and Reagents; D007783:Lactones / Q000138:chemical synthesis*; D011161:Porifera / Q000737:chemistry; D011753:Pyrones; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D000970:Antineoplastic Agents; D002219:Carbamates; D007202:Indicators and Reagents; D007783:Lactones; D011753:Pyrones; C071229:discodermolide