Interleukin 16: implications for CD4 functions and HIV-1 progression.
In this article, David Center and colleagues clarify the controversies that have emerged over the unique structure of interleukin 16 and its anti-HIV-1 activity. Interleukin 16 is a ligand for CD4, and this implies CD4 acts as a sentinel receptor that can switch CD4+ T cells between immune and inflammatory functions.
Center
D M
DM
Evans Memorial Department of Medicine, Pulmonary Center at Boston University School of Medicine, MA 02118, USA. dcenter@lung.bumc.bu.edu
Kornfeld
H
H
Ryan
T C
TC
Cruikshank
W W
WW
D000818:Animals; D001665:Binding Sites; D015704:CD4 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D019281:Dimerization; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D015497:HIV-1; D006706:Homeostasis; D006801:Humans; D007249:Inflammation; D019410:Interleukin-16 / Q000097:blood / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D017434:Protein Structure, Tertiary; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism
D015704:CD4 Antigens; D019410:Interleukin-16; D008024:Ligands; D011948:Receptors, Antigen, T-Cell; D011993:Recombinant Fusion Proteins