title: Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons.
abstract: Ginsenosides isolated from ginseng are biologically active components. In this study, whole-cell and inside-out configurations of patch clamp technique had been used to test the effect of ginsenosides on the capsaicin-activated channels in cultured small diameter sensory neurons of young rat. Ginsenosides (100 microg/ml) decreased the amplitude of capsaicin-activated currents by 78.2% in whole cell mode. Similarly, ginsenosides decreased capsaicin-activated single-channel activities in a dose-dependent manner in inside-out patches. These results indicate that ginsenosides might directly block capsaicin-activated channels, resulting in attenuation of the currents in rat sensory neurons.
authors.affiliation: Department of Physiology, Chung-Ang University School of Medicine, 156-756, Seoul, South Korea.
authors.forename: J
authors.initials: J
authors.lastname: Hahn
authors.forename: S Y
authors.initials: SY
authors.lastname: Nah
authors.forename: J J
authors.initials: JJ
authors.lastname: Nah
authors.forename: D Y
authors.initials: DY
authors.lastname: Uhm
authors.forename: S
authors.initials: S
authors.lastname: Chung
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D002491:Central Nervous System Agents / Q000494:pharmacology*; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D036145:Ginsenosides; D009475:Neurons, Afferent / Q000187:drug effects* / Q000378:metabolism; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010146:Pain / Q000188:drug therapy / Q000503:physiopathology; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D011955:Receptors, Drug / Q000187:drug effects* / Q000378:metabolism*; D012503:Saponins / Q000494:pharmacology*
chemical_list: D015220:Calcium Channels; D002491:Central Nervous System Agents; D036145:Ginsenosides; D011955:Receptors, Drug; D012503:Saponins