title: Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus.
abstract: Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).
authors.affiliation: Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
authors.forename: I A
authors.initials: IA
authors.lastname: Parshikov
authors.forename: J P
authors.initials: JP
authors.lastname: Freeman
authors.forename: J O
authors.initials: JO
authors.lastname: Lay
authors.forename: R D
authors.initials: RD
authors.lastname: Beger
authors.forename: A J
authors.initials: AJ
authors.lastname: Williams
authors.forename: J B
authors.initials: JB
authors.lastname: Sutherland
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D009682:Magnetic Resonance Spectroscopy; D009089:Mucor / Q000254:growth & development / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin