Recurrent venous thrombosis in a patient with chronic lymphocytic leukemia and acquired protein S deficiency.
A patient with chronic lymphocytic leukemia and an undetectable plasma level of protein S (PS), associated with recurrent venous thrombosis, is described. The laboratory investigation revealed the concomitant presence of an inhibitor directed to PS and a monoclonal protein in the patient's plasma. After treatment with prednisone and cyclophosphamide both the inhibitor to PS and the monoclonal component disappeared.
Miljić
P
P
Institute of Haematology, University Clinical Center, Belgrade, Yugoslavia.
Milosević-Jovicić
N
N
Antunović
P
P
Bosković
D
D
Basara
N
N
Rolović
Z
Z
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000008:administration & dosage; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage; D018455:Protein S Deficiency / Q000097:blood / Q000209:etiology*; D012008:Recurrence; D020246:Venous Thrombosis / Q000209:etiology*
D003520:Cyclophosphamide; D011241:Prednisone