Drug discovery in the next millennium.
Selection and validation of novel molecular targets have become of paramount importance in light of the plethora of new potential therapeutic drug targets that have emerged from human gene sequencing. In response to this revolution within the pharmaceutical industry, the development of high-throughput methods in both biology and chemistry has been necessitated. This review addresses these technological advances as well as several new areas that have been created by necessity to deal with this new paradigm, such as bioinformatics, cheminformatics, and functional genomics. With many of these key components of future drug discovery now in place, it is possible to map out a critical path for this process that will be used into the new millennium.
Ohlstein
E H
EH
Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406-0939, USA. ohlstein@sbphrd.com
Ruffolo
R R
RR
Elliott
J D
JD
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004345:Drug Industry; D015316:Genetic Therapy; D015894:Genome, Human; D006801:Humans