title: Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38.
abstract: Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.
authors.affiliation: Eisai Research Institute, Andover, MA 01810, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: G J
authors.initials: GJ
authors.lastname: Habgood
authors.forename: W J
authors.initials: WJ
authors.lastname: Christ
authors.forename: Y
authors.initials: Y
authors.lastname: Kishi
authors.forename: B A
authors.initials: BA
authors.lastname: Littlefield
authors.forename: M J
authors.initials: MJ
authors.lastname: Yu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003110:Colonic Neoplasms; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D004988:Ethers, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia; D018942:Macrolides; D051379:Mice; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured; D000095662:Polyether Polyketides
chemical_list: D000970:Antineoplastic Agents; D004988:Ethers, Cyclic; D018942:Macrolides; C070519:halichondrin B; D000095662:Polyether Polyketides