title: TREK-1 is a heat-activated background K(+) channel.
abstract: Peripheral and central thermoreceptors are involved in sensing ambient and body temperature, respectively. Specialized cold and warm receptors are present in dorsal root ganglion sensory fibres as well as in the anterior/preoptic hypothalamus. The two-pore domain mechano-gated K(+) channel TREK-1 is highly expressed within these areas. Moreover, TREK-1 is opened gradually and reversibly by heat. A 10 degrees C rise enhances TREK-1 current amplitude by approximately 7-fold. Prostaglandin E2 and cAMP, which are strong sensitizers of peripheral and central thermoreceptors, reverse the thermal opening of TREK-1 via protein kinase A-mediated phosphorylation of Ser333. Expression of TREK-1 in peripheral sensory neurons as well as in central hypothalamic neurons makes this K(+) channel an ideal candidate as a physiological thermoreceptor.
authors.affiliation: Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France. ipmc@ipmc.cnrs.fr
authors.forename: F
authors.initials: F
authors.lastname: Maingret
authors.forename: I
authors.initials: I
authors.lastname: Lauritzen
authors.forename: A J
authors.initials: AJ
authors.lastname: Patel
authors.forename: C
authors.initials: C
authors.lastname: Heurteaux
authors.forename: R
authors.initials: R
authors.lastname: Reyes
authors.forename: F
authors.initials: F
authors.lastname: Lesage
authors.forename: M
authors.initials: M
authors.lastname: Lazdunski
authors.forename: E
authors.initials: E
authors.lastname: Honoré
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D019556:COS Cells; D002522:Chlorocebus aethiops; D000242:Cyclic AMP / Q000494:pharmacology; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D015232:Dinoprostone / Q000494:pharmacology; D005727:Ganglia, Spinal / Q000737:chemistry; D006358:Hot Temperature; D007124:Immunoenzyme Techniques; D015640:Ion Channel Gating; D017136:Ion Transport; D051379:Mice; D008807:Mice, Inbred BALB C; D016297:Mutagenesis, Site-Directed; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D009865:Oocytes; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D024683:Potassium Channels, Tandem Pore Domain; D011817:Rabbits; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000502:physiology; D015398:Signal Transduction; D013823:Thermoreceptors / Q000187:drug effects / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D000911:Antibodies, Monoclonal; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; D011993:Recombinant Fusion Proteins; C103742:potassium channel protein TREK-1; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases; D015232:Dinoprostone; D011188:Potassium