title: Reduced phosphodiesters and high-energy phosphates in the frontal lobe of schizophrenic patients: a (31)P chemical shift spectroscopic-imaging study.
abstract: BACKGROUND
  (31)Phosphorous magnetic resonance spectroscopy has been widely used to evaluate schizophrenic patients in comparison to control subjects, because it allows the investigation of both phospholipid and energy metabolism in vivo; however, the results achieved so far are inconsistent. Chemical shift imaging (CSI) has the advantage that instead of only one or a few preselected voxels the tissue of a whole brain slice can be examined. The aim of the present investigation was to determine whether the results of previous studies of our group, showing that phosphodiesters (PDE) are decreased in the frontal lobe of schizophrenic patients as compared to control subjects, might be confirmed in an independent unmedicated patient sample using the CSI technique.
  
  
  METHODS
  A carefully selected new cohort including 11 neuroleptic-free schizophrenic patients and 11 age- and gender-matched healthy control subjects was recruited. CSI was applied and an innovative analysis method for CSI data based on a general linear model was used.
  
  
  RESULTS
  PDE, phosphocreatine, and adenosine triphosphate (ATP) were found to be significantly decreased in the frontal lobe of patients with schizophrenia.
  
  
  CONCLUSIONS
  Because PDE was decreased in schizophrenic patients, the membrane phospholipid hypothesis of schizophrenia could not be corroborated. Further results indicate decreased ATP production in the frontal lobe of patients with schizophrenia.
authors.affiliation: Department of Psychiatry, University of Jena, Germany.
authors.forename: H R
authors.initials: HR
authors.lastname: Volz
authors.forename: S
authors.initials: S
authors.lastname: Riehemann
authors.forename: I
authors.initials: I
authors.lastname: Maurer
authors.forename: S
authors.initials: S
authors.lastname: Smesny
authors.forename: M
authors.initials: M
authors.lastname: Sommer
authors.forename: R
authors.initials: R
authors.lastname: Rzanny
authors.forename: W
authors.initials: W
authors.lastname: Holstein
authors.forename: J
authors.initials: J
authors.lastname: Czekalla
authors.forename: H
authors.initials: H
authors.lastname: Sauer
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D001921:Brain / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008959:Models, Neurological; D010755:Organophosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010759:Phosphorus Isotopes; D012559:Schizophrenia / Q000378:metabolism*
chemical_list: D010755:Organophosphates; D010743:Phospholipids; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D000255:Adenosine Triphosphate