title: A two-step total synthesis of the natural pentacycle trichodimerol, a novel inhibitor of TNF-alpha production.
abstract: [formula: see text] Trichodimerol (1) can be synthesized by a remarkable dimerization of the chiral hydroxy dienone 5.
authors.affiliation: Department of Chemistry and Chemical Biology Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: D
authors.initials: D
authors.lastname: Barnes-Seeman
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D015394:Molecular Structure; D013057:Spectrum Analysis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D001952:Bridged-Ring Compounds; D014409:Tumor Necrosis Factor-alpha; C099299:trichodimerol