title: [The spike reactions of the motor cortex neurons of old rabbits to specific stimuli].
abstract: Spike reactions of motor cortex neurons to tactile and electrocutaneous stimulation of a forelimb were studied in aged (6-7-year old) rabbits. As compared with young adult animals, the neuronal reactions to afferent stimuli were rarely recorded in the motor cortex of aged rabbits (66.7 and 50%, respectively). The activation manifested in increasing firing rate over its spontaneous level was less intensive than in young animals. The neuronal reactions of aged animals were characterized by the slower activation with longer latencies and slower development of spike responses. The parameters of slow activation could be partly corrected by the iontophoretic application of acetylcholine to the soma region. Neuronal inhibition recorded in the motor cortex of aged rabbits was not markedly changed compared to inhibition reactions in young animals. It is suggested that impairment of the functional state of dendrites in aging is responsible for the changes observed.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Mednikova
authors.forename: F V
authors.initials: FV
authors.lastname: Kopytova
authors.forename: T N
authors.initials: TN
authors.lastname: Dish
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D016009:Chi-Square Distribution; D004558:Electric Stimulation; D004576:Electromyography / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D011817:Rabbits; D012879:Skin Physiological Phenomena; D018709:Statistics, Nonparametric; D014110:Touch / Q000502:physiology
chemical_list: D000109:Acetylcholine