The first synthesis of clausenamine-A and cytotoxic activities of three biscarbazole analogues against cancer cells.
Clausemine-A (3), isolated from the stem and root bark of Clausena excavata, was synthesized using Suzuki cross-coupling and Oxidative coupling as the key step. Compound 3, and the other two structurally related biscarbazoles 1 and 2, showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.
Zhang
A
A
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
Lin
G
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002227:Carbazoles; C413726:clausenamine A