Increased CSF levels of nerve growth factor in patients with Alzheimer's disease.
The authors quantitated CSF levels of nerve growth factor (NGF) in patients with AD, nondemented control subjects (CTR), and age-matched patients with major depression (DE). CSF levels of NGF were markedly higher in the AD group than in both the CTR and DE groups (p < 0.01 and p < 0.001). Increased CSF levels of NGF in AD patients may reflect reported accumulation of NGF in the AD brain and may constitute a candidate marker for clinical diagnosis and therapeutic monitoring.
Hock
C
C
Department of Psychiatry Research, University of Zürich, Switerzland.
Heese
K
K
Müller-Spahn
F
F
Huber
P
P
Riesen
W
W
Nitsch
R M
RM
Otten
U
U
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests
D015415:Biomarkers; D020932:Nerve Growth Factor