Hypercalcemia in a patient with renal cell carcinoma producing parathyroid hormone-related protein and interleukin-6.
A patient with renal cell carcinoma who developed humoral hypercalcemia of malignancy is reported. A 52-year-old male patient was diagnosed with renal cell carcinoma and multiple lung metastases. A cell line isolated from the surgical specimen exhibited continuous production of parathyroid hormone-related protein (PTHrP) in vitro. The production of PTHrP from the cancer cells was confirmed by RT-PCR and immunoradiometric assay. The serum calcium level was not enhanced, whereas the lung lesion was developing and producing interleukin-6, a possible modulator of osteoclastic resorption. Hypercalcemia was induced when the PTHrP concentration increased up to 3.3 pmol/L.
Ueno
M
M
Department of Urology, Kidney Disease Center, Saitama Medical School, Iruma, Japan. camtmune@saitama-med.ac.jp
Ban
S
S
Nakanoma
T
T
Tsukamoto
T
T
Nonaka
S
S
Hirata
R
R
Iida
M
M
Deguchi
N
N
D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D015850:Interleukin-6 / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008297:Male; D008875:Middle Aged; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis
D015850:Interleukin-6; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D012333:RNA, Messenger