Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity.
An overview is given of the results of metal ion-diclofenac interactions. Several complexes have been synthesized at the University of Ioannina. Binuclear complexes, [Cu(L)2(H2O)]2 x 2H2O and [CuL2(S)]2 where S is H2O, EtOH, DMSO, (CH3)2CO and DMF, and mononuclear complexes, [MnL2(H2O)], [FeL2(H2O)2], [CoL2(H2O)2] x 0.5H2O, [CoL2(H2O)], [NiL2(H2O)2] x 2H2O, [NiL2] and [PdL2] x 2H2O, have been characterized by spectroscopy, X-ray crystallography and electrochemical studies. The catalytic activity of these complexes was correlated to the reduction potential. Some of the complexes of diclofenac exhibit very promising anti-inflammatory activity and act as antioxidant compounds, a property that is absent from diclofenac.
Kovala-Demertzi
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Department of Chemistry, University of Ioannina, Greece. dkovala@cc.uoi.gr
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002351:Carrageenan; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D004563:Electrochemistry; D007501:Iron / Q000737:chemistry; D008345:Manganese / Q000737:chemistry; D019216:Metals, Heavy / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D008982:Molybdenum / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019216:Metals, Heavy; D004008:Diclofenac; D003035:Cobalt; D008345:Manganese; D010165:Palladium; D003300:Copper; D009532:Nickel; D008982:Molybdenum; D002351:Carrageenan; D007501:Iron