[Experimental study of combined effect of actoprotectors and radioprotectors in radiation injury].
Combined treatment of mice and dogs with actoprotector bimethyl and radioprotector indralin suppressed radioprotective action of the latter, the surveillance being decreased from 83.3 to 14.3% in dogs and from 70.3 to 5% in mice. At the same time vasodynamic action of indralin (increase of artherial pressure up to 30% from a reference level) did not change.
Korovkina
E P
EP
State Research Centre of Russia-Institute of Biophysics, Moscow.
Mikhaĭlov
P P
PP
Izvekov
V N
VN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004336:Drug Antagonism; D051379:Mice; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use
D000975:Antioxidants; D001562:Benzimidazoles; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin; C049825:bemethyl