title: Primary T-cell lymphoma of the brain in children: a case report and literature review.
abstract: Described here are the clinical features and results of treatment in a 10-year-old Saudi Arabian girl with primary T-cell lymphoma of the central nervous system. At presentation the patient had nystagmus and ataxia. The diagnosis was established by tissue biopsy obtained from the cerebellum. Therapy included cranio-spinal irradiation and combination chemotherapy of a systemic high dose of methotrexate, cytosine, arabinoside, and L-asparaginase. Remission was obtained easily but was interrupted by a local intracranial relapse 57 months after diagnosis (37 months after cessation of therapy; at present the patient is still alive and receiving palliative treatment). This report is warranted because of the rarity of this condition in children.
authors.affiliation: King Faisal Specialist Hospital & Research Center, Division of Pediatric Hematology Oncology, Riyadh, Kingdom of Saudi Arabia.
authors.forename: H
authors.initials: H
authors.lastname: al-Ghamdi
authors.forename: R
authors.initials: R
authors.lastname: Sabbah
authors.forename: J
authors.initials: J
authors.lastname: Martin
authors.forename: Z
authors.initials: Z
authors.lastname: Patay
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001089:Arabinose / Q000627:therapeutic use; D001215:Asparaginase / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D002648:Child; D003131:Combined Modality Therapy; D003596:Cytosine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D008727:Methotrexate / Q000627:therapeutic use; D012008:Recurrence; D012074:Remission Induction
chemical_list: D003596:Cytosine; D001089:Arabinose; D001215:Asparaginase; D008727:Methotrexate