title: Enantioselective parallel synthesis using polymer-supported chiral Co(salen) complexes.
abstract: [formula: see text] The kinetic resolution of epoxides with phenols catalyzed by a polymer-supported Co(salen) complex is applied to the first enantioselective catalytic synthesis of parallel libraries. The corresponding 1-aryloxy-2-alcohols are obtained in high yield, purity, and enantiomeric excess. Further elaboration with diversity elements provides highly efficient access to important classes of pharmacologically active compounds.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: S
authors.initials: S
authors.lastname: Peukert
authors.forename: E N
authors.initials: EN
authors.lastname: Jacobsen
mesh_terms: D003035:Cobalt / Q000737:chemistry; D005029:Ethylenediamines / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D005029:Ethylenediamines; D011108:Polymers; D003035:Cobalt; C011452:disalicylaldehyde ethylenediamine