title: [Ways to improve ocular bioavailability for topical applications].
abstract: The anatomical, physiological and pharmacological properties of the eye explain the short pre-corneal residence time and the poor bioavailability of most eye-drop solutions. Many approaches have been proposed to increase ocular bioavailability of drugs. Most eye-drops include a viscosity agent in their formulation to significantly prolong residence time although the increased viscosity is limited due to patient discomfort. More recent developments include biodegradable inserts, eye-drop based on cyclodextrins, liposomes or nanoparticles.
authors.affiliation: Cabinet d'Ophtalmologie, 15 rue du Dôme, F-67000 Strasbourg.
authors.forename: D
authors.initials: D
authors.lastname: Sirbat
authors.forename: L
authors.initials: L
authors.lastname: Marchal-Heussler
authors.forename: M
authors.initials: M
authors.lastname: Hoffman
authors.forename: P
authors.initials: P
authors.lastname: Maincent
mesh_terms: D001682:Biological Availability; D005123:Eye / Q000378:metabolism*; D006801:Humans; D009883:Ophthalmic Solutions / Q000493:pharmacokinetics*; D011355:Prodrugs / Q000493:pharmacokinetics
chemical_list: D009883:Ophthalmic Solutions; D011355:Prodrugs