title: Who's your neighbor? New computational approaches for functional genomics.
abstract: Several recently developed computational approaches in comparative genomics go beyond sequence comparison. By analyzing phylogenetic profiles of protein families, domain fusions, gene adjacency in genomes, and expression patterns, these methods predict many functional interactions between proteins and help deduce specific functions for numerous proteins. Although some of the resultant predictions may not be highly specific, these developments herald a new era in genomics in which the benefits of comparative analysis of the rapidly growing collection of complete genomes will become increasingly obvious.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda MD 20894, USA.
authors.forename: M Y
authors.initials: MY
authors.lastname: Galperin
authors.forename: E V
authors.initials: EV
authors.lastname: Koonin
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D016208:Databases, Factual; D016678:Genome; D005810:Multigene Family; D010802:Phylogeny; D011506:Proteins / Q000145:classification / Q000235:genetics*; D012984:Software; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins