title: [Monitoring of the inflammation in children before and after tonsillectomy].
abstract: A group of 54 children aged from three to 13 years was qualified to tonsillectomy for laryngological indications. In sera of all children following measurements were performed: the concentrations of C-reactive protein (CRP), alpha1-acid glycoprotein (AGP) and alpha1-antichymotrypsin (ACT) were measured using rocket immunoelectrophoresis according to Laurell, also concentrations of three main immunoglobulin classes (IgA, IgG, IgM) and antistreptolysin titer. The microheterogeneity of both AGP and ACT was investigated, using crossed affinity immunoelectrophoresis according to Bog-Hansen with Concanavalin A (Con A) as a ligand. Results were expressed as reactivity coefficients (RC), being the proportion of all Con A-reacting variants to the non-reacting variant. It is worth mentioning that there was no difference in all investigated parameters as well between groups obtained by categorizing children according to the presence or absence of elevated antistreptolysin titer. It may mean that at least in some cases the chronic inflammation was caused by streptococci non-producing streptolysin O. The results obtained suggest that the absence of the arthritic pain does not exclude the need of antibiotic therapy in children after tonsillectomy. Generally it is postulated that estimation of acute phase proteins concentrations and glycosylation profiles, which were previously shown to be useful in clinical assessment of various diseases may serve as additional marker in laryngology in cases where indications to tonsillectomy are still controversial.
authors.affiliation: Klinika Otolaryngologii Dzieciecej Instytutu Pediatrii Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu.
authors.forename: I
authors.initials: I
authors.lastname: Steiner
authors.forename: M
authors.initials: M
authors.lastname: Sobieska
authors.forename: M
authors.initials: M
authors.lastname: Grzegorowski
authors.forename: K
authors.initials: K
authors.lastname: Wiktorowicz
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011182:Postoperative Care; D011300:Preoperative Care; D013290:Streptococcal Infections; D014068:Tonsillectomy / Q000379:methods*; D014069:Tonsillitis / Q000517:prevention & control* / Q000601:surgery*
chemical_list: D015415:Biomarkers