Evolutionary optimisation of enzymes.
Aside from the demonstration that individual molecular traits of enzymes can be evolutionarily optimised, the discovery that several traits can be simultaneously optimised is a major advance. The first observations of the effects of evolutionary optimisation at the structural level, through X-ray crystallography, reinforce the view that enzymes are best optimised by evolution and not by design.
Sutherland
J D
JD
Department of Chemistry, The University of Manchester, Manchester, M13 9PL, UK. john.sutherland@man.ac.uk
D019020:Directed Molecular Evolution; D004798:Enzymes / Q000737:chemistry*
D004798:Enzymes