Altered responsiveness of medial prefrontal cortex neurons to glutamate and dopamine after withdrawal from repeated amphetamine treatment.
Using in vivo extracellular single-cell recording and microiontophoresis, we compared the responsiveness of medial prefrontal cortex (mPFC) neurons (layers V-VI) to dopamine and glutamate in rats that had received repeated amphetamine or saline injections. Neurons from amphetamine-pretreated rats showed increased responsiveness to glutamate and decreased responsiveness to dopamine after three days of withdrawal, suggesting that the mPFC is transiently hyperexcitable during amphetamine withdrawal. Published 2000 Wiley-Liss, Inc.
Peterson
J D
JD
Department of Neuroscience, Finch University of Health Sciences/The Chicago Medical School, North Chicago, IL 60064-3095, USA.
Wolf
M E
ME
White
F J
FJ
D000661:Amphetamine / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology*; D007478:Iontophoresis; D008297:Male; D009474:Neurons / Q000187:drug effects*; D017397:Prefrontal Cortex / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D018698:Glutamic Acid; D000661:Amphetamine; D004298:Dopamine