title: Introduction of heteroatom-based substituents into 1,4-dihydropyridines by means of a halogen-mediated, oxidative protocol: diamination, sulfonylation, sulfinylation, bis-sulfanylation, and halo-phosphonylation processes
abstract: The natural tendency of 1,4-dihydropyridines to undergo "biomimetic" oxidation to afford pyridinium salts can be switched off and, through the use of reagents that interact electrophilically with the enamine moiety present in the heterocyclic system, it is possible to promote alternative oxidations. In this way, efficient regio- and stereocontrolled synthetic methods have been developed that lead to diversely substituted di- and tetrahydropyridines. These include iodoazidation, diamination, bis-sulfonamidation, sulfonylation, sulfinylation, thiocyanation, sulfanylation, bis-sulfanylation, and halo-phosphonylation processes.
authors.affiliation: Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Spain. lavilla@farmacia.far.ub.es
authors.initials: R
authors.lastname: Lavilla
authors.initials: R
authors.lastname: Kumar
authors.initials: O
authors.lastname: Coll
authors.initials: C
authors.lastname: Masdeu
authors.initials: A
authors.lastname: Spada
authors.initials: J
authors.lastname: Bosch
authors.initials: E
authors.lastname: Espinosa
authors.initials: E
authors.lastname: Molins