An anterograde degeneration study of the distribution of regenerating rat myelinated fibers in the silicone chamber model.
Specificity of reinnervation after a peripheral nerve lesion has given rise to considerable controversy. As a contribution to solving this issue we have evaluated the specificity of reinnervation of the peroneal nerve after a complete transection of the sciatic nerve repaired with an 8 mm silicone tube, leaving a 4 mm gap between the nerve stumps. Our findings reveal unspecificity of reinnervation of the distal peroneal branch. This lack of specificity is shown by a random distribution of fibers originating from both proximal branches at the level of the tube and at distal peroneal and tibial branches, argue against specificity of regeneration in this model.
Alzate
L H
LH
Laboratorio de Neurociencias, Instituto Nacional de Salud, Avenida Eldorado, Carrera 50, Zona 6, Santafé de, Bogotá, Colombia.
Sutachan
J J
JJ
Hurtado
H
H
D000818:Animals; D002452:Cell Count; D004195:Disease Models, Animal; D009410:Nerve Degeneration / Q000473:pathology* / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000378:metabolism* / Q000473:pathology*; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones; D013997:Time Factors
D012828:Silicones