title: A case of combined nevus: compound nevus and spindle cell Spitz nevus.
abstract: Combined nevi consisting of a Spitz nevus and an acquired nevus are unusual, and, to our knowledge, the combination of a spindle cell Spitz nevus and an overlying compound nevus has not been previously reported. We report a 17-year-old girl with a nodule on the left anterior lower extremity. The nodule was asymptomatic, firm, brown, symmetrical, dome-shaped, 8 mm in diameter, and not found with ulceration. Histological findings showed proliferation of spindle-shaped cells with an overlying compound nevus. The spindle-shaped cells were large, non-pigmented, uniform in size and shape, with rare mitoses and without nuclear atypia, and arranged in a storiform pattern in thick collagen bundles. They stained positively for S-100 and negatively for HMB-45. The lesion was considered to be a new type of combined nevus consisting of a spindle cell Spitz nevus and an overlying compound nevus.
authors.affiliation: Department of Dermatology, Fukui Medical University, Japan.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Jin
authors.forename: M
authors.initials: M
authors.lastname: Kumakiri
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Kinebuchi
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007866:Leg; D008544:Melanocytes / Q000473:pathology; D009506:Nevus / Q000473:pathology*; D018332:Nevus, Epithelioid and Spindle Cell / Q000473:pathology*; D018330:Nevus, Intradermal / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*