[Analysis of the association between the T113M polymorphism of the human il-9 gene and bronchial asthma].
The T113M polymorphism resulting from the missense mutation in exon 5 of the human interleukin 9 (IL9) gene was tested for association with bronchial asthma (BA). The genotype frequency analysis did not reveal a deviation from the Hardy-Weinberg equilibrium. A comparison of the genotype frequency distributions in a control group of healthy individuals and in patients with BA suggested an association between T113M and the clinical phenotype. However, this association was not confirmed by the affected family-based association control (AFBAC) or the transmission/disequilibrium test (TDT).
Freĭdin
M B
MB
Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Russia.
Puzyrev
V P
VP
Ogorodova
L M
LM
Saliukova
O A
OA
Kamaltynova
E M
EM
Kulmanakova
I M
IM
Petrovskaia
Iu A
IuA
D000483:Alleles; D001249:Asthma / Q000235:genetics*; D006801:Humans; D016906:Interleukin-9 / Q000235:genetics*; D011110:Polymorphism, Genetic
D016906:Interleukin-9