Effect of Maytenus aquifolium extract on the pharmacokinetic and antiinflammatory effectiveness of piroxicam in rats.
This study explored the interference by Maytenus aquifolium leaves hydroalcoholic (MALHE) extract, administered orally, on the pharmacokinetic and antiinflammatory activity of piroxicam in rats. The results showed no significant difference in piroxicam bioavailability with simultaneous application of MALHE. MALHE also had no effect on the inhibitory effect of piroxicam on inflammatory processes induced by carrageenan and complete Freund adjuvant.
Kimura
E
E
Department of Pharmacy and Pharmacology of the Maringá State University, Brazil.
Albiero
A L
AL
Cuman
R K
RK
Caparroz-Assef
S M
SM
Oga
S
S
Bersani-Amado
C A
CA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy*; D001938:Brazil; D008297:Male; D008519:Medicine, Traditional; D009169:Mycobacterium tuberculosis; D010894:Piroxicam / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D010894:Piroxicam