Intracranial sarcoma in a patient with neurofibromatosis type 2 treated with gamma knife radiosurgery for vestibular schwannoma.
OBJECTIVE
To discuss the possible relationship between stereotactic radiation therapy and the development of a meningosarcoma.


METHODS
Retrospective case review.


METHODS
A 19-year-old woman with bilateral vestibular schwannomas (neurofibromatosis type 2). One large tumor was removed totally by the translabyrinthine approach; the other smaller tumor was treated with stereotactic radiation (SRT). Six years after SRT, a malignant tumor (meningosarcoma) developed at the exact site of radiation. The patient subsequently died of this tumor.


METHODS
On the basis of literature surveys, the possibility and risk of postirradiation neoplasia after SRT is discussed. Furthermore, the possible causal association between SRT and the development of the meningosarcoma in this case is evaluated.


CONCLUSIONS
On the basis of statistical considerations, the development of the reported mesenchymal sarcoma was most likely caused by the stereotactic radiation therapy.
Thomsen
J
J
Department of Otorhinolaryngology-Head and Neck Surgery, Gentofte University Hospital, Hellerup, Denmark.
Mirz
F
F
Wetke
R
R
Astrup
J
J
Bojsen-Møller
M
M
Nielsen
E
E
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008866:Microsurgery / Q000379:methods; D016518:Neurofibromatosis 2 / Q000150:complications* / Q000175:diagnosis; D009464:Neuroma, Acoustic / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D012509:Sarcoma / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed