title: Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment.
abstract: Recombinant human deoxyribonuclease (rhDNase) is a mucolytic agent used to relieve peripheral airway obstruction in patients with cystic fibrosis. We report dramatic sustained improvement following the intratracheal administration of rhDNase to a 3-yr-old boy with acute life-threatening asthma in whom 48 h of aggressive therapy had failed.
authors.affiliation: Department of Paediatric Intensive Care, Guy's Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Patel
authors.forename: E
authors.initials: E
authors.lastname: Harrison
authors.forename: A
authors.initials: A
authors.lastname: Durward
authors.forename: I A
authors.initials: IA
authors.lastname: Murdoch
mesh_terms: D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D003850:Deoxyribonuclease I / Q000008:administration & dosage*; D005100:Expectorants / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D005100:Expectorants; D011994:Recombinant Proteins; D003850:Deoxyribonuclease I