Inhibition of protein phosphatases by Michael adducts of ascorbic acid analogues with alpha,beta-unsaturated carbonyl compounds.
By investigating the stereospecific Michael reaction of derivatives of ascorbic acid with acrolein we obtained a novel class of protein Ser/Thr phosphatase inhibitors. The inhibitory effect of the Michael adducts was examined using the canonical protein phosphatases type 1, 2A and 2B. Of the isozymes examined the type 1 isoform was strongly inhibited.
Witt
U G
UG
Institut für Pharmazie, Universität Leipzig, Germany.
Schultz
J E
JE
Dölker
M
M
Eger
K
K
D000171:Acrolein / Q000737:chemistry*; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D013057:Spectrum Analysis
D000171:Acrolein; D010749:Phosphoprotein Phosphatases; D001205:Ascorbic Acid