title: Evolutionary optimisation of enzymes.
abstract: Aside from the demonstration that individual molecular traits of enzymes can be evolutionarily optimised, the discovery that several traits can be simultaneously optimised is a major advance. The first observations of the effects of evolutionary optimisation at the structural level, through X-ray crystallography, reinforce the view that enzymes are best optimised by evolution and not by design.
authors.affiliation: Department of Chemistry, The University of Manchester, Manchester, M13 9PL, UK. john.sutherland@man.ac.uk
authors.forename: J D
authors.initials: JD
authors.lastname: Sutherland
mesh_terms: D019020:Directed Molecular Evolution; D004798:Enzymes / Q000737:chemistry*
chemical_list: D004798:Enzymes