title: Antinociceptive effect of the essential oil from Cymbopogon citratus in mice.
abstract: The essential oil (EO) from leaves of Cymbopogon citratus increased the reaction time to thermal stimuli both after oral (25 mg/kg) and intraperitoneal (25-100 mg/kg) administration. EO (50-200 mg/kg, p.o. or i.p.) strongly inhibited the acetic acid-induced writhings in mice. In the formalin test, EO (50 and 200 mg/kg, i.p.) inhibited preferentially the second phase of the response, causing inhibitions of 100 and 48% at 200 mg/kg, i.p. and 100 mg/kg, p.o., respectively. On the other hand, the opioid antagonist naloxone blocked the central antinociceptive effect of EO, suggesting that EO acts both at peripheral and central levels.
authors.affiliation: Department of Physiology and Pharmacology, Federal University of Ceará, Rua Cel., Nunes de Melo 1127, 60431-970, Fortaleza, Brazil. gsbviana@secrelnet.com.br
authors.forename: G S
authors.initials: GS
authors.lastname: Viana
authors.forename: T G
authors.initials: TG
authors.lastname: Vale
authors.forename: R S
authors.initials: RS
authors.lastname: Pinho
authors.forename: F J
authors.initials: FJ
authors.lastname: Matos
mesh_terms: D000085:Acetates; D000700:Analgesics / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D017691:Caribbean Region; D002849:Chromatography, Gas; D005557:Formaldehyde; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D006109:Poaceae / Q000737:chemistry*; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000085:Acetates; D000700:Analgesics; D009292:Narcotic Antagonists; D009822:Oils, Volatile; D005557:Formaldehyde; D009270:Naloxone