Antioxidant associated chemoprevention by selenomethionine in murine tumor model.
Effectiveness of selenium in different forms like sodium selenite, selenocysteine and selenomethionine has been compared in four different doses, namely 4, 6, 8 and 10 ppm of each, in terms of their bioavailability and prolongation of survival of Dalton's lymphoma (DL) bearing mice. Selenomethionine, at a dose of 8 ppm, was found to be the most bioavailable and least-cytotoxic form that was capable of increasing the life span of the tumour bearing hosts maximally (almost two-fold). Beneficiality of selenomethionine has also been studied by observing continuous changes brought about by this compound on the glutathione (GSH) level, glutathione peroxidase (GPx) activity and extent of lipid peroxidation in the hepatic tissue of the tumour bearing hosts, which are indispensable for a cell to function normally and are found to exhibit significantly altered behaviour in neoplastic cells. Selenomethionine caused the maintenance of high steady state GSH level and a normal GPx activity during the fist phase of tumour growth. It also controlled lipid peroxidation during the first 15-20 days following tumour transplantation. These conditions helped in the maintenance of intracellular redox balance, cellular integrity and metabolic rhythms of cells in DL bearing mice receiving selenomethionine.
Mukhopadhyay-Sardar
S
S
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.
Rana
M P
MP
Chatterjee
M
M
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000633:toxicity; D001202:Ascitic Fluid; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D051379:Mice; D010534:Peritoneal Neoplasms / Q000378:metabolism / Q000401:mortality / Q000517:prevention & control*; D012645:Selenomethionine / Q000008:administration & dosage* / Q000633:toxicity; D015996:Survival Rate
D000975:Antioxidants; D012645:Selenomethionine; D005979:Glutathione Peroxidase; D005978:Glutathione