title: Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model.
abstract: From the aerial parts of Decatropis bicolor, heraclenin (1), seselin (2), psoralen (3), imperatorin (4), skimmianine (5), and heraclenol (6), were isolated. This is the first time that coumarin-like compounds are isolated from Decatropis genus. The anti-inflammatory properties of compounds 1-6 were examined against the ear edema in mice produced by TPA. The results suggest that the anti-inflammatory activity of each compound depends of its individual substitution on the aromatic ring rather than the coumarin skeleton itself.
authors.forename: A N
authors.initials: AN
authors.lastname: García-Argáez
authors.forename: T O
authors.initials: TO
authors.lastname: Ramírez Apan
authors.forename: H
authors.initials: H
authors.lastname: Parra Delgado
authors.forename: G
authors.initials: G
authors.lastname: Velázquez
authors.forename: M
authors.initials: M
authors.lastname: Martínez-Vázquez
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003374:Coumarins; D013755:Tetradecanoylphorbol Acetate