[Feasibility of 400 microm spheroids by extrusion-spheronization].
Extrusion-spheronisation technology is an agglomeration process that makes it possible to obtain spheroids. The aim of this work was to obtain 400microm spheroids that could be sprinkled on food to improve patient observance in particular with children and old people. A methodology to select wet masses for extrusion-spheronisation through a 400microm orifice was developed. First, it was nesessary to define the parameters that make it possible to appreciate the qualities that the wet mass and the extrudates have to possess and their method of evaluation: plasticity, cohesiveness, brittleness of the mass and the extrudates, appearance of extrudates. A feasibility assay made on the drum extruder was then performed. After proving the feasibility of 400microm spheroids of Gelucire 50/02 we considered the association of a drug with it.
Flament
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Faculté de Pharmacie - Laboratoire de Pharmacotechnie Industrielle, 3, rue du Professeur Laguesse, BP 83 59006 Lille Cedex, France.
Leterme
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Gayot
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D004339:Drug Compounding; D008863:Microspheres; D010316:Particle Size