title: Vitamin D receptor gene polymorphisms and susceptibility to Mycobacterium malmoense pulmonary disease.
abstract: Polymerase chain reaction using sequence-specific primers was utilized to ascertain the prevalence of 3 polymorphisms of the vitamin D receptor (VDR) gene (FokI F/f, ApaI A/a, and TaqI T/t) in 56 patients with Mycobacterium malmoense pulmonary disease. When compared with 101 controls, M. malmoense patients displayed an increased prevalence of Apa1 A (P=.03; Fisher's exact test), TaqI t (P=.04), and the At VDR haplotype (P=.04), and they displayed a decreased prevalence of FokI f (P=.04). Only 4 (7%) of 56 patients (vs. 29 [28%] of 101 controls) were both positive for FokI f and negative for At (P=.001). This indicates that polymorphisms in the VDR (or in closely linked genes) modulate the susceptibility to M. malmoense and that susceptibility involves multiple genetic and environmental factors.
authors.affiliation: Dept. of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XX, Wales, United Kingdom. GelderCM@cf.ac.uk
authors.forename: C M
authors.initials: CM
authors.lastname: Gelder
authors.forename: K W
authors.initials: KW
authors.lastname: Hart
authors.forename: O M
authors.initials: OM
authors.lastname: Williams
authors.forename: E
authors.initials: E
authors.lastname: Lyons
authors.forename: K I
authors.initials: KI
authors.lastname: Welsh
authors.forename: I A
authors.initials: IA
authors.lastname: Campbell
authors.forename: S E
authors.initials: SE
authors.lastname: Marshall
mesh_terms: D004198:Disease Susceptibility; D006239:Haplotypes; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D009164:Mycobacterium Infections / Q000209:etiology*; D009894:Opportunistic Infections / Q000209:etiology*; D010641:Phenotype; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol