title: [Effectiveness and safety of ciclopirox olamine 1% vaginal cream versus terconazole 0.8% vaginal cream in the treatment of genital candidiasis].
abstract: A multicenter randomized study was performed. One hundred and seventy patients were selected. The patients were 18 years and older. They presented signs and symptoms of genital candidiasis and had positive smear culture for Candida. Eighty five patients were assigned to receive Cicloprox olamine 1%, and eighty five patients were assigned to receive Terconazol 0.8%. The treatment lasted six days with the objective to compare the clinical and antifungal efficiency and safety with both treatments. The result of mixed efficiency (clinical and microbiology) for Cicloprox olamine was 48 cases (62.3%) at the end of the treatment were cured--day 7-; and at the continuation--day 21-42 of them had the same result (55.3%); improvement was seen at the end in 25 cases (32.5%) and at the continuation 21 cases had the same result (27.6%). For Terconazol the result was 45 cases (61.6%) were cured at the end of the treatment, and at the continuation 39 had the same result (57.4%); improvement was seen at the end in 23 cases (31.5%) and at the continuation 22 cases had the same result (32.4%). We conclude that both treatments are effective and well tolerated for genital candidiasis treatment.
authors.affiliation: Centro Médico Nacional 20 de Noviembre ISSSTE.
authors.forename: R G
authors.initials: RG
authors.lastname: García Figueroa
authors.forename: L
authors.initials: L
authors.lastname: Sauceda
authors.forename: D
authors.initials: D
authors.lastname: Ramírez Palacios
authors.forename: F
authors.initials: F
authors.lastname: Cruz Talonia
authors.forename: R
authors.initials: R
authors.lastname: Romero Cabello
mesh_terms: D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D000077768:Ciclopirox; D005260:Female; D006801:Humans; D011728:Pyridones / Q000627:therapeutic use*; D014230:Triazoles / Q000627:therapeutic use*; D014622:Vaginal Creams, Foams, and Jellies
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; D014230:Triazoles; D014622:Vaginal Creams, Foams, and Jellies; C037815:terconazole; D000077768:Ciclopirox