title: A case of malignant transformation in thoracic vertebral hemangioma following repetitive irradiation and extraction.
abstract: We report a rare case of thoracic vertebral hemangioma which developed into angiosarcoma during the course of repetitive operations and irradiation. A 44 year old female was operated on for hemangioma of the first thoracic vertebra. The diagnosis of hemangioma was confirmed histopathologically with the specimen from the first operation. The tumor developed multiple lesions later in the clinical course after the first operation, these lesions were removed in four consecutive operations and each histological diagnosis was that of hemangioma. Throughout the period of these operations, the patient was treated with steroid, and with radiotherapy simultaneously. The patient underwent the fifth operation for the recurrence of the tumor on 26 March 1990, and the histopathological diagnosis was not hemangioma but hemangiosarcoma which was considered a malignant transformation. The tumor cells immunohistochemically revealed positive staining with UEA-I, Factor-VIII, as the tumor immunohistochemically showed a vascular endothelioid nature.
authors.affiliation: Department of Clinical Pathology, Kinki University School of Medicine, Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Obana
authors.forename: K
authors.initials: K
authors.lastname: Tanji
authors.forename: I
authors.initials: I
authors.lastname: Furuta
authors.forename: T
authors.initials: T
authors.lastname: Yamazumi
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: H
authors.initials: H
authors.lastname: Kikuchi
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ohba
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000528:radiation effects; D017809:Fatal Outcome; D005260:Female; D006391:Hemangioma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D006394:Hemangiosarcoma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009381:Neoplasms, Radiation-Induced / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D013125:Spinal Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D013904:Thoracic Vertebrae
chemical_list: D014408:Biomarkers, Tumor