title: Comparison of methods of measurements of oxygen consumption in mechanically ventilated patients with multiple trauma: the Fick method versus indirect calorimetry.
abstract: OBJECTIVE
  The purpose of this study was to compare the measurements of whole body oxygen consumption determined by the Fick method and by indirect calorimetry in mechanically ventilated patients with multiple trauma.
  
  
  METHODS
  A prospective, correlational, within-subjects design.
  
  
  METHODS
  Surgical intensive care unit of a Level I trauma center.
  
  
  METHODS
  Thirty-eight mechanically ventilated adults with multiple injuries who received a pulmonary artery catheter within 24 hrs of admission to the surgical intensive care unit.
  
  
  RESULTS
  After the initial resuscitation, simultaneous measurements of oxygen consumption (V(O2) by the reverse Fick equation and by indirect calorimetry were performed every 6 hrs for 24 hrs in normothermic patients who were at rest for at least 30 mins. At each measurement period, the mean V(O2) values determined by indirect calorimetry were significantly greater than the mean V(O2) values determined by the Fick method (time 1: 172+/-38 vs. 125+/-47 mL/min/m2, p < .0001; time 2: 170+/-31 vs. 130+/-48 mL/min/m2, p < .0001; time 3: 170+/-32 vs. 132+/-53 mL/min/m2, p < .0001; time 4: 169+/-29 vs. 130+/-60 mL/min/m2, p < .0002). By using the Bland and Altman technique, the mean bias was 41+/-3.95 mL/min/m2. Correlation coefficients of VO2 values between methods of measurements were statistically significant (r2 = .32, p = .0001; r2 = .32, p = .0001; r2 = .33, p = .0001; r2 = .18, p = .0001).
  
  
  CONCLUSIONS
  Indirect calorimetry should be the preferred standard for measurement of oxygen consumption in severely injured patients.
authors.affiliation: Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: C D
authors.initials: CD
authors.lastname: Epstein
authors.forename: J R
authors.initials: JR
authors.lastname: Peerless
authors.forename: J E
authors.initials: JE
authors.lastname: Martin
authors.forename: M A
authors.initials: MA
authors.lastname: Malangoni
mesh_terms: D000328:Adult; D000368:Aged; D002153:Calorimetry, Indirect; D002408:Catheters, Indwelling; D003422:Critical Care; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000503:physiopathology / Q000628:therapy; D009104:Multiple Trauma / Q000503:physiopathology / Q000628:therapy*; D010101:Oxygen Consumption / Q000502:physiology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011651:Pulmonary Artery; D012121:Respiration, Artificial