title: Two cases of hypothyroidism complicated by renal dysfunction.
abstract: We report two patients in whom hypothyroidism was considered to cause renal dysfunction. Case 1 was a 65-year-old woman who stopped taking levothyroxine sodium for hypothyroidism. After 6 months, she developed proteinuria, edema, weight gain, and renal dysfunction. Renal biopsy revealed focal segmental proliferative glomerulonephritis. After re-administration of levothyroxine sodium, thyroid function and renal function both recovered. Case 2 was a 51-year-old man who presented with edema, difficulty in swallowing, muscular weakness, and fatigue. We diagnosed hypothyroidism, and focal segmental proliferative glomerulonephritis was revealed by renal biopsy. After administration of levothyroxine sodium, his symptoms resolved and his thyroid function and renal function both improved. Our experience suggests that hypothyroidism should be taken into consideration as one of the causes of renal dysfunction.
authors.affiliation: Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ogata
authors.forename: N
authors.initials: N
authors.lastname: Yorioka
authors.forename: C
authors.initials: C
authors.lastname: Tanji
authors.forename: Y
authors.initials: Y
authors.lastname: Asakimori
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Masaki
authors.forename: Y
authors.initials: Y
authors.lastname: Nishida
authors.forename: Y
authors.initials: Y
authors.lastname: Taniguchi
authors.forename: M
authors.initials: M
authors.lastname: Yamakido
mesh_terms: D000368:Aged; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000209:etiology* / Q000503:physiopathology; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged