title: Dose requirements of infusions of cisatracurium or rocuronium during hypothermic cardiopulmonary bypass.
abstract: We investigated the influence of mild hypothermic cardiopulmonary bypass (CPB) on the dose requirements of cisatracurium or rocuronium used as a continuous infusion. We studied eight patients given cisatracurium and nine given rocuronium. They were ASA class III and IV and scheduled for elective coronary artery bypass grafting. Neuromuscular transmission was monitored electromyographically. After recovery of T1/T0 to 10%, a cisatracurium infusion or a rocuronium infusion was started at a rate of 1.5 or 10 micrograms kg-1 min-1, respectively, and adjusted to maintain T1/T0 at 15%. Infusion rate and duration were recorded before, during and after CPB in each patient and the mean infusion rates were calculated. One-way ANOVA showed a statistically significant difference between the cisatracurium infusion rates before, during and after CPB: A T1/T0 of 15% could be achieved with a mean infusion rate of 1.1, 0.75 and 0.98 micrograms kg-1 min-1 before, during and after CPB, respectively. There was no significant difference between the rocuronium infusion rates before, during and after CPB. The mean rocuronium infusion rate required to maintain T1/T0 at 15% throughout the procedure was 4.1 micrograms kg-1 min-1. Cisatracurium infusion rates should be halved during CPB. Even after CPB, requirements are reduced. The same tendency occurs with rocuronium, but the changes in infusion rate were not statistically significant.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, OLV-Ziekenhuis, Aalst, Belgium.
authors.forename: G
authors.initials: G
authors.lastname: Cammu
authors.forename: J
authors.initials: J
authors.lastname: Coddens
authors.forename: J
authors.initials: J
authors.lastname: Hendrickx
authors.forename: T
authors.initials: T
authors.lastname: Deloof
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000732:Androstanols / Q000008:administration & dosage*; D001279:Atracurium / Q000008:administration & dosage* / Q000031:analogs & derivatives; D002315:Cardiopulmonary Bypass / Q000379:methods*; D004576:Electromyography / Q000187:drug effects; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007262:Infusions, Intravenous / Q000379:methods; D008297:Male; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage*
chemical_list: D000732:Androstanols; D009466:Neuromuscular Blocking Agents; D001279:Atracurium