title: Nipah virus: a recently emergent deadly paramyxovirus.
abstract: A paramyxovirus virus termed Nipah virus has been identified as the etiologic agent of an outbreak of severe encephalitis in people with close contact exposure to pigs in Malaysia and Singapore. The outbreak was first noted in late September 1998 and by mid-June 1999, more than 265 encephalitis cases, including 105 deaths, had been reported in Malaysia, and 11 cases of encephalitis or respiratory illness with one death had been reported in Singapore. Electron microscopic, serologic, and genetic studies indicate that this virus belongs to the family Paramyxoviridae and is most closely related to the recently discovered Hendra virus. We suggest that these two viruses are representative of a new genus within the family Paramyxoviridae. Like Hendra virus, Nipah virus is unusual among the paramyxoviruses in its ability to infect and cause potentially fatal disease in a number of host species, including humans.
authors.affiliation: Department of Medical Microbiology, University of Malaya Medical Center, 50603 Kuala Lumpur, Malaysia.
authors.forename: K B
authors.initials: KB
authors.lastname: Chua
authors.forename: W J
authors.initials: WJ
authors.lastname: Bellini
authors.forename: P A
authors.initials: PA
authors.lastname: Rota
authors.forename: B H
authors.initials: BH
authors.lastname: Harcourt
authors.forename: A
authors.initials: A
authors.lastname: Tamin
authors.forename: S K
authors.initials: SK
authors.lastname: Lam
authors.forename: T G
authors.initials: TG
authors.lastname: Ksiazek
authors.forename: P E
authors.initials: PE
authors.lastname: Rollin
authors.forename: S R
authors.initials: SR
authors.lastname: Zaki
authors.forename: W
authors.initials: W
authors.lastname: Shieh
authors.forename: C S
authors.initials: CS
authors.lastname: Goldsmith
authors.forename: D J
authors.initials: DJ
authors.lastname: Gubler
authors.forename: J T
authors.initials: JT
authors.lastname: Roehrig
authors.forename: B
authors.initials: B
authors.lastname: Eaton
authors.forename: A R
authors.initials: AR
authors.lastname: Gould
authors.forename: J
authors.initials: J
authors.lastname: Olson
authors.forename: H
authors.initials: H
authors.lastname: Field
authors.forename: P
authors.initials: P
authors.lastname: Daniels
authors.forename: A E
authors.initials: AE
authors.lastname: Ling
authors.forename: C J
authors.initials: CJ
authors.lastname: Peters
authors.forename: L J
authors.initials: LJ
authors.lastname: Anderson
authors.forename: B W
authors.initials: BW
authors.lastname: Mahy
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks; D018792:Encephalitis, Viral / Q000453:epidemiology / Q000821:virology*; D004730:Endothelium, Vascular / Q000473:pathology / Q000821:virology; D005814:Genes, Viral; D015726:Giant Cells / Q000473:pathology / Q000821:virology; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D019251:Nucleocapsid / Q000648:ultrastructure; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000635:transmission / Q000662:veterinary / Q000821:virology*; D018098:Paramyxovirinae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000648:ultrastructure; D010802:Phylogeny; D012137:Respiratory System / Q000821:virology; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D017422:Sequence Analysis, DNA; D012846:Singapore / Q000453:epidemiology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology; D014657:Vasculitis / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D014764:Viral Proteins