Diaryl ethers using Fischer chromium carbene mediated benzannulation.
[formula: see text] The biological relevance and irresistible synthetic challenge of compounds containing the diaryl ether linkage encourages the development of new methodologies targeted toward this structural subunit. The syntheses of diaryl ethers 2 using a benzannulation strategy that formally involves a [3 + 2 + 1] cycloaddition between aryloxy-substituted Fischer carbenes 1 and alkynes are described. This methodology provides a neutral near ambient temperature formation of diaryl ethers.
Pulley
S R
SR
Department of Chemistry, University of Missouri-Columbia 65211-7600, USA. pulleys@missouri.edu
Sen
S
S
Vorogushin
A
A
Swanson
E
E
D000480:Alkynes / Q000737:chemistry; D002857:Chromium / Q000737:chemistry; D003500:Cyclization; D009942:Organometallic Compounds / Q000737:chemistry; D010647:Phenyl Ethers / Q000138:chemical synthesis*; D014465:Ultrasonics
D000480:Alkynes; D009942:Organometallic Compounds; D010647:Phenyl Ethers; D002857:Chromium