Gastric cytoprotection of bolivian medicinal plants.
Several extracts obtained from Bolivian medicinal plants have been evaluated for cytoprotective activity on ethanol-induced ulcer formation in rats. Preliminary results suggest, that the majority of the plants tested showed a significant activity, the aqueous extracts of Phoradendron crassifolium and Franseria artemisioides being the most active, exerting a cytoprotective activity comparable to atropine. The analysis of the chemical constituents of the extracts studied showed the presence of tanins, saponins, flavonoids and coumarins.
Gonzales
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Instituto de Investigaciones Fármaco-Bioquimícas, Facultad de Farmacia, Universidad Mayor de San Andres, 3239, La Paz, Bolivia.
Iglesias
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Carretero
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Villar
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A
D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D001838:Bolivia; D002855:Chromatography, Thin Layer; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000897:Anti-Ulcer Agents; D018727:Muscarinic Antagonists; D001285:Atropine