title: Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities.
abstract: High-dose therapy (HDT) has increased complete remission (CR) rates and survival in multiple myeloma (MM). We now report on continuous CR (CCR) and associated prognostic factors in 1000 consecutive patients receiving melphalan-based tandem HDT. Five-year CCR was 52% among 112 CR patients without chromosome 13 (triangle up13) abnormalities and with beta-2-microglobulin </= 2.5 mg/L, C-reactive protein </= 4 mg/L, and pre-HDT standard chemotherapy </= 12 months. Of all 390 CR patients without triangle up13 abnormalities, 35% enjoyed 5-year CCR but none of 54 with triangle up13 abnormalities. triangle up13 abnormalities, present in overall 16%, reduced 5-year event-free survival from 20% to 0% and overall survival from 44% to 16% (both P <.0001). CR and a second HDT cycle applied within 6 months both extended event-free and overall survival significantly, justifying further pursuit of HDT, especially toward curing non-triangle up13 MM. (Blood. 2000;95:4008-4010)
authors.affiliation: Myeloma and Transplantation Research Center and Division of Biometry, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
authors.forename: R
authors.initials: R
authors.lastname: Desikan
authors.forename: B
authors.initials: B
authors.lastname: Barlogie
authors.forename: J
authors.initials: J
authors.lastname: Sawyer
authors.forename: D
authors.initials: D
authors.lastname: Ayers
authors.forename: G
authors.initials: G
authors.lastname: Tricot
authors.forename: A
authors.initials: A
authors.lastname: Badros
authors.forename: M
authors.initials: M
authors.lastname: Zangari
authors.forename: N C
authors.initials: NC
authors.lastname: Munshi
authors.forename: E
authors.initials: E
authors.lastname: Anaissie
authors.forename: D
authors.initials: D
authors.lastname: Spoon
authors.forename: D
authors.initials: D
authors.lastname: Siegel
authors.forename: S
authors.initials: S
authors.lastname: Jagannath
authors.forename: D
authors.initials: D
authors.lastname: Vesole
authors.forename: J
authors.initials: J
authors.lastname: Epstein
authors.forename: J
authors.initials: J
authors.lastname: Shaughnessy
authors.forename: A
authors.initials: A
authors.lastname: Fassas
authors.forename: S
authors.initials: S
authors.lastname: Lim
authors.forename: P
authors.initials: P
authors.lastname: Roberson
authors.forename: J
authors.initials: J
authors.lastname: Crowley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D018572:Disease-Free Survival; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors
chemical_list: D008558:Melphalan