Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function.
The principles of Darwinian evolution have been explored in molecular systems such as autocatalytic networks and dynamic combinatorial libraries. Molecular evolution in such systems manifests itself as ligand or receptor amplification by selection. Research efforts exploring these concepts may provide a mechanism for the identification of novel catalysts, molecular receptors and bioactive molecules.
Cousins
G R
GR
University Chemical Laboratory, University of Cambridge, CB2 1EW, UK.
Poulsen
S A
SA
Sanders
J K
JK
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D019020:Directed Molecular Evolution