title: The cultural heritage shapes the pattern of tumour profiles in Europe: a correlation study.
abstract: OBJECTIVE
  This study investigates the spatial pattern of tumours in Europe to check the feasibility of a large scale ecological epidemiology approach to cancer in Europe.
  
  
  METHODS
  The tumour types relative frequencies and cancer incidence (for men and women) reported in the European cancer registries were investigated by exploratory data analysis techniques. Socioeconomical descriptors of the female condition were considered as well.
  
  
  RESULTS
  The classification of the European regional areas covered by the cancer registries followed almost exactly the boundaries set by the long and intermingled European history in terms of life styles and cultural heritage. This result supports the notion of a predominant role of environmental factors in cancer induction. Further support to the above result was given by the finding of a correlation between differential male-female cancer incidence, and socioeconomic descriptors of the female condition.
  
  
  CONCLUSIONS
  From a methodological point of view, the consistency of these results pointed to the feasibility of an ecological approach to tumour epidemiology.
authors.affiliation: Istituto Superiore di Sanitá, Toxicology and Ecotoxicology Laboratory, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Benigni
authors.forename: R
authors.initials: R
authors.lastname: Giaimo
authors.forename: D
authors.initials: D
authors.lastname: Matranga
authors.forename: A
authors.initials: A
authors.lastname: Giuliani
mesh_terms: D018864:Cultural Diversity; D003468:Cultural Evolution; D005060:Europe / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009369:Neoplasms / Q000145:classification / Q000453:epidemiology* / Q000209:etiology; D011159:Population Surveillance / Q000379:methods; D015995:Prevalence; D012042:Registries / Q000145:classification / Q000706:statistics & numerical data*; D012737:Sex Factors; D012959:Socioeconomic Factors