title: The role of red blood cell polymorphisms in resistance and susceptibility to malaria.
abstract: In regions highly endemic for Plasmodium falciparum malaria, red cell polymorphisms that confer resistance to severe disease are widespread. Sickle cell trait, alpha-thalassemia, glucose-6-phosphate dehydrogenase deficiency, and blood groups were determined in 100 children from Gabon with severe malaria who were matched with 100 children with mild malaria and followed up for evaluation of reinfections. The sickle cell trait was significantly associated with mild malaria and blood group A with severe malaria. During follow-up, the original severe cases had significantly higher rates of reinfection than the original mild cases, with higher parasitemia and lower hematocrit values. Incidence rates did not differ in the context of erythrocyte polymorphisms, but patients with sickle cell trait presented with markedly lower levels of parasitemia than those without. Thus, the severity of malaria is partly determined by the presence of blood group A and the sickle cell trait. The different presentation of reinfections in severe versus mild cases probably reflects different susceptibility to malaria.
authors.affiliation: Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Lell
authors.forename: J
authors.initials: J
authors.lastname: May
authors.forename: R J
authors.initials: RJ
authors.lastname: Schmidt-Ott
authors.forename: L G
authors.initials: LG
authors.lastname: Lehman
authors.forename: D
authors.initials: D
authors.lastname: Luckner
authors.forename: B
authors.initials: B
authors.lastname: Greve
authors.forename: P
authors.initials: P
authors.lastname: Matousek
authors.forename: D
authors.initials: D
authors.lastname: Schmid
authors.forename: K
authors.initials: K
authors.lastname: Herbich
authors.forename: F P
authors.initials: FP
authors.lastname: Mockenhaupt
authors.forename: C G
authors.initials: CG
authors.lastname: Meyer
authors.forename: U
authors.initials: U
authors.lastname: Bienzle
authors.forename: P G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004912:Erythrocytes; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics; D006801:Humans; D008137:Longitudinal Studies; D016778:Malaria, Falciparum / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000469:parasitology; D008297:Male; D011110:Polymorphism, Genetic; D012008:Recurrence; D012720:Severity of Illness Index; D012805:Sickle Cell Trait / Q000235:genetics*; D017085:alpha-Thalassemia / Q000235:genetics
chemical_list: D000017:ABO Blood-Group System