Survival and failure to thrive in the SIV-infected juvenile rhesus monkey.
In AIDS patients, wasting in adults and failure to thrive in children are common and devastating problems. Weight loss in rhesus macaques infected with simian immunodeficiency virus (SIV) has not been well characterized. The purpose of this study was to determine growth curves in SIV-infected juvenile macaques to determine the effects of SIV infection on body weight and growth. Medical records of seven juvenile male SIV-infected macaques were retrospectively reviewed to determine body weights, survival time, CD4 count, and viral load. Mean age and body weight at the time of inoculation were 63.3 weeks and 2.4 kg, respectively. Mean survival was 73.7 weeks, and mean body weight at the time of death was 3.0 kg, whereas the published mean body weight for this age of male rhesus macaque is 4.1 kg. Compared with the linear growth pattern of normal animals, the growth pattern for the SIV-infected animals exhibited strong nonlinearity with an inflection point at the mean survival of 74 weeks. After this time point, the discrepancy between growth curves for infected and healthy animals increased at a greater rate. Body weight correlated inversely with viral load (r = -0.368; p = .003) but there was no correlation between body weight and CD4 count. The results of this study suggest that failure to thrive is a consequence of SIV infection and may be related to severity of infection.
Freeman
L M
LM
Department of Clinical Sciences, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA. Lfreeman@infonet.tufts.edu
Mansfield
K G
KG
Lackner
A A
AA
Naumova
E N
EN
Gorbach
S L
SL
D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D005183:Failure to Thrive / Q000209:etiology* / Q000503:physiopathology; D008253:Macaca mulatta / Q000254:growth & development*; D008297:Male; D012189:Retrospective Studies; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000401:mortality / Q000503:physiopathology; D015996:Survival Rate