Immunoglobulin related amyloidosis presenting as isolated lymph node and pulmonary involvement.
Here we present an unusual case of a 53-year old patient presenting AL-kappa amyloidosis with diffuse-type amyloidosis of lungs, lymph nodes and pleura. The underlying pathology was a B-cell immunoglobulin-secreting non-Hodgkin lymphoma, as proven by the presence of a monoclonal B-cell population in the bone marrow. Diffuse parenchymal infiltration of the lungs is extremely rare in non-systemic amyloidosis, with only 4 previous cases having been reported in the English literature.
Meeus
G
G
Department of Internal Medicine, Gasthuisberg University Hospital, Leuven, Belgium.
Ponette
J
J
Delabie
J
J
Verschakelen
J
J
Blockmans
D
D
D000686:Amyloidosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D001797:Blood Protein Electrophoresis; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007122:Immunoelectrophoresis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008168:Lung / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology*; D008206:Lymphatic Diseases / Q000209:etiology*; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000175:diagnosis; D010266:Paraproteins / Q000032:analysis*; D011507:Proteinuria / Q000209:etiology
D007145:Immunoglobulin kappa-Chains; D010266:Paraproteins