Eosinophilic bronchopneumopathy in dogs.
Eosinophilic bronchopneumopathy was diagnosed in 23 young dogs. Clinical signs included cough, gagging, and retching in all dogs, dyspnea in 21 dogs (91%), and nasal discharge in 12 dogs (52%). The most common radiographic findings were a moderate to severe bronchointerstitial pattern (68%, 13 of 19 dogs). Bronchoscopic findings included the presence of abundant yellow-green mucus or mucopurulent material (70%, 16 of 23 dogs) and severe mucosal thickening with an irregular or polypoid appearance (52%, 12 of 23 dogs), with partial airway closure during expiration in 3 dogs (13%). Peripheral blood eosinophilia was noted in 14 of 23 dogs (61%). Inflammatory cells in brush or bronchoalveolar lavage fluid cytologic preparations comprised more than 50% eosinophils in 14 of 23 dogs (61%), and 20-50% eosinophils in 6 dogs (26%). Eosinophilic infiltration of the bronchial mucosa was observed in biopsies from 19 dogs and was graded as mild (37%, 7 dogs), moderate (32%, 6 dogs), or severe (32%, 6 dogs). The mean serum immunoglobulin A concentration was almost double that of a population of 20 healthy dogs of various breeds. Oral glucocorticoids were administered on alternate days with progressive tapering of the dose; the dosage at maintenance varied between 0.1 and 1.0 mg/kg every other day. No relationship was found between the duration of clinical signs and the maintenance dosage or the cytologic and histopathologic grades.
Clercx
C
C
Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium. cclercx@ulg.ac.be
Peeters
D
D
Snaps
F
F
Hansen
P
P
McEntee
K
K
Detilleux
J
J
Henroteaux
M
M
Day
M J
MJ
D000818:Animals; D018893:Bronchoalveolar Lavage / Q000662:veterinary; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D001996:Bronchopneumonia / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D001999:Bronchoscopy / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D005260:Female; D008168:Lung / Q000166:cytology; D008297:Male; D011657:Pulmonary Eosinophilia / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D011859:Radiography; D012189:Retrospective Studies; D016896:Treatment Outcome