Pharmacogenetic prediction of clozapine response.
We did association studies in multiple candidate genes to find the combination of polymorphisms that give the best predictive value of response to clozapine in schizophrenic patients. A combination of six polymorphisms in neurotransmitter-receptor-related genes resulted in 76.7% success in the prediction of clozapine response (p=0.0001) and a sensitivity of 95% (+/- 0.04) for satisfactory response. These results will form the basis for a simple test to enhance the usefulness of clozapine in psychiatric treatment.
Arranz
M J
MJ
Munro
J
J
Birkett
J
J
Bolonna
A
A
Mancama
D
D
Sodhi
M
M
Lesch
K P
KP
Meyer
J F
JF
Sham
P
P
Collier
D A
DA
Murray
R M
RM
Kerwin
R W
RW
D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D003024:Clozapine / Q000627:therapeutic use*; D005838:Genotype; D006801:Humans; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011985:Receptors, Serotonin / Q000235:genetics*; D012680:Sensitivity and Specificity
D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; D003024:Clozapine