Synthesis of trisubstituted alkenes via olefin cross-metathesis.
[formula: see text] Trisubstituted alkenes have been prepared for the first time via intermolecular olefin cross-metathesis, using 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ruthenium alkylidene complexes 3a,b in good yields with moderate E selectivity. In addition, protected alcohols near the geminal disubstituted olefin improve reactivity for cross-metathesis.
Chatterjee
A K
AK
Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena 91125, USA.
Grubbs
R H
RH
D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007093:Imidazoles / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
D000475:Alkenes; D007093:Imidazoles; D012428:Ruthenium