title: An animal model based on the Sprague Dawley rat for the evaluation of ototoxicity.
abstract: Various methodological approaches that can be used to detect ototoxic effects caused by the administration of various substances are presented, using the Sprague-Dawley rat as an animal model. Electrophysiological data are also presented to show how the model behaves with potentially ototoxic (hyaluronic acid) and initially inert (hydroxy-propyl-methyl-cellulose) substances.
authors.affiliation: Department of ENT, Audiology, University of Ferrara, Italy. mma@dns.unife.it
authors.forename: A
authors.initials: A
authors.lastname: Martini
authors.forename: S
authors.initials: S
authors.lastname: Hatzopoulos
authors.forename: R
authors.initials: R
authors.lastname: Rubini
authors.forename: M
authors.initials: M
authors.lastname: Di Stefano
authors.forename: A
authors.initials: A
authors.lastname: Albertin
authors.forename: E
authors.initials: E
authors.lastname: Govoni
mesh_terms: D000161:Acoustic Stimulation; D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D000818:Animals; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D006820:Hyaluronic Acid / Q000009:adverse effects*; D007785:Lactose / Q000009:adverse effects / Q000031:analogs & derivatives*; D008747:Methylcellulose / Q000009:adverse effects / Q000031:analogs & derivatives*; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000187:drug effects / Q000502:physiology; D010078:Oxazines; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000276:Adjuvants, Immunologic; D010078:Oxazines; D006820:Hyaluronic Acid; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose