title: Specificity of detection of Chlamydia pneumoniae in cardiovascular atheroma.
abstract: Chlamydia pneumoniae is commonly detected in atherosclerotic plaque but the frequency of detection in non-cardiovascular (CV) tissues has not been well determined. In this study, archival autopsy tissue specimens from both CV and non-CV sites from 38 patients were tested by polymerase chain reaction and immunocytochemistry to detect C. pneumoniae. In addition, 33 surgical granuloma biopsy specimens were also tested. C. pneumoniae was detected most frequently in coronary artery tissue (34%) but was also detected in specimens from lung (13%), liver (10%), spleen (5%), bone marrow (10%), and lymph node (8%). The organism was detected in 3 of 33 granuloma specimens. These findings suggest that C. pneumoniae demonstrates a tropism for CV tissues and is either not widely distributed to non-CV tissues or does not persist chronically in those tissues after initial infection.
authors.affiliation: Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98101-1448, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Jackson
authors.forename: L A
authors.initials: LA
authors.lastname: Campbell
authors.forename: R A
authors.initials: RA
authors.lastname: Schmidt
authors.forename: C
authors.initials: C
authors.lastname: Kuo
authors.forename: A L
authors.initials: AL
authors.lastname: Cappuccio
authors.forename: M J
authors.initials: MJ
authors.lastname: Lee
authors.forename: J T
authors.initials: JT
authors.lastname: Grayston
mesh_terms: D001158:Arteries / Q000382:microbiology; D001853:Bone Marrow / Q000382:microbiology; D002690:Chlamydia Infections / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000235:genetics / Q000302:isolation & purification*; D003324:Coronary Artery Disease / Q000382:microbiology*; D003331:Coronary Vessels / Q000382:microbiology*; D006099:Granuloma / Q000382:microbiology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000382:microbiology; D008168:Lung / Q000382:microbiology; D008221:Lymphoid Tissue / Q000382:microbiology; D016133:Polymerase Chain Reaction