title: Neurocardiovascular instability, hypotensive episodes, and MRI lesions in neurodegenerative dementia.
abstract: We investigated whether carotid sinus hypersensitivity (CSH) and orthostatic hypotension (OH) were associated with a greater severity of hyperintensities on MRI scan in 30 patients with neurodegenerative dementia (17 dementia with Lewy bodies, 13 Alzheimer's disease), who had a detailed evaluation of OH and CSH during active standing and head-up tilt. Patients also underwent a 1.0 Tesla MRI scan, from which hyperintensities were rated on a standardized scale. A blood pressure (BP) drop > 30 mm Hg during carotid sinus massage or active standing was significantly associated with the severity of MRI hyperintensities in the deep white matter (OR 10.0, 95%; CI 1.8-55.7) and in the basal ganglia (OR 11.0, 95%; CI 1.2-99.5) but not in periventricular areas (OR 1.4, 95%; CI 0.3-1.8). Patients with the cardio-inhibitory form of CSH with the largest BP drops were the most at risk. Further longitudinal studies need to investigate the direction of causality to determine whether CSH or OH predispose to MRI hyperintensities and accelerate cognitive decline.
authors.affiliation: Institute for the Health of the Elderly, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom. c.g.ballard@ncl.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Ballard
authors.forename: J
authors.initials: J
authors.lastname: O'Brien
authors.forename: B
authors.initials: B
authors.lastname: Barber
authors.forename: P
authors.initials: P
authors.lastname: Scheltens
authors.forename: F
authors.initials: F
authors.lastname: Shaw
authors.forename: I
authors.initials: I
authors.lastname: McKeith
authors.forename: R A
authors.initials: RA
authors.lastname: Kenny
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D001479:Basal Ganglia / Q000473:pathology; D001794:Blood Pressure; D001921:Brain / Q000473:pathology*; D002346:Carotid Sinus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic; D020961:Lewy Body Disease / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male