title: Granular-cell tumor of trachea masquerading as Hurthle-cell neoplasm on fine-needle aspirate: a case report.
abstract: We report on a case of extraluminal tracheal granular-cell tumor which was interpreted as a Hurthle-cell neoplasm of the thyroid on fine-needle aspirate. Review of the literature reveals only one other such case. The patient was a 35-yr-old female who presented with an enlarged thyroid. Aspiration cytology revealed a syncytium of cells with abundant granular cytoplasm interpreted as a thyroid follicular neoplasm with Hurthle-cell change. However, histology of the resection specimen with immunohistochemistry confirmed it as a granular-cell tumor. The cytologic differential diagnosis of neoplasms with oncocytoid cytoplasm in and around the thyroid should include granular-cell tumor of the trachea.
authors.affiliation: Department of Pathology, University of Michigan Hospitals, Ann Arbor, Michigan 48109-0054, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Kintanar
authors.forename: T J
authors.initials: TJ
authors.lastname: Giordano
authors.forename: N W
authors.initials: NW
authors.lastname: Thompson
authors.forename: C W
authors.initials: CW
authors.lastname: Michael
mesh_terms: D018249:Adenoma, Oxyphilic / Q000737:chemistry / Q000175:diagnosis*; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D007124:Immunoenzyme Techniques; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000175:diagnosis*; D014134:Tracheal Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor