title: alpha-Glycosidase inhibitory activity of hexagalloylglucose from the galls of Quercus infectoria.
abstract: Hexagalloylglucose (3-O-digalloyl-1,2,4,6-tetra-O-galloyl-beta-D- glucose), which was isolated from the methanol extract of the galls of Quercus infectoria, significantly inhibited alpha-glycosidases such as sucrase, maltase and isomaltase. Its inhibitory activity was comparable to acarbose being used as a hypoglycemic agent, while the inhibitory activity on alpha-amylase was approximately 10 times lower than that of acarbose. The results indicate that, when compared to acarbose, hexagalloylglucose might reduce the side effects by reducing inhibition of alpha-amylase.
authors.forename: J K
authors.initials: JK
authors.lastname: Hwang
authors.forename: T W
authors.initials: TW
authors.lastname: Kong
authors.forename: N I
authors.initials: NI
authors.lastname: Baek
authors.forename: Y R
authors.initials: YR
authors.lastname: Pyun
mesh_terms: D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D010935:Plant Diseases
chemical_list: C409902:3-O-digalloyl-1,2,4,6-tetra-O-galloylglucose; D004791:Enzyme Inhibitors; D005960:Glucosides; D005707:Gallic Acid; D006026:Glycoside Hydrolases