Voltage dependence of ICD lead polarization and the effect of iridium oxide coating.
Nonthoracotomy leads (NTLs) with an iridium oxide (IROX) coating exhibit lower defibrillation thresholds (DFTs) than uncoated NTLs. We tested whether adding an IROX coating to an active pectoral can would influence defibrillation efficacy. However, the primary purpose of this study was to examine the impedance changes that occur at different voltages for uncoated titanium NTLs and identical NTLs with an IROX coating. We studied anesthetized pigs with an NTL placed in the right ventricle and coupled this to an active pectoral can. Biphasic waveform DFTs were obtained for the four NTLs and can combinations: uncoated NTL and uncoated can, uncoated NTL and IROX can, IROX NTL and uncoated can, and IROX NTL and IROX can. The respective energy DFTs were: 23.6 +/- 6.9, 24.1 +/- 6.7, 21.3 +/- 6.0, and 21.4 +/- 7.0 J. The IROX NTL DFTs were significantly lower (P < 0.05) than the uncoated NTL DFTs (either can), confirming our previous study. We then used a low tilt monophasic waveform to assess impedance changes. The impedance rise for each NTL/can combination was measured at 50, 100, 300, and 700 V. Comparisons of impedance changes between voltage levels showed that the impedance rise was inversely related to voltage and was greatest with uncoated NTLs. The IROX coating of the NTL reduced the impedance rise at all shock voltages, but was particularly beneficial at the lower voltages. No advantage was seen when the pectoral can was coated with IROX regardless of which NTL was used. Our results suggest that low voltage applications, such as atrial defibrillation, would benefit most from the IROX-coated NTL, and further studies are warranted in this area.
Niebauer
M J
MJ
Department of Cardiology, Cleveland Clinic Foundation, Ohio. niebaum@cesmtp.ccf.org
Yamanouchi
Y
Y
Hills
D
D
Mowrey
K
K
Wilkoff
B L
BL
Tchou
P J
PJ
D000818:Animals; D020099:Coated Materials, Biocompatible; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D004567:Electrodes, Implanted; D004699:Endocardium; D007495:Iridium; D013552:Swine; D014025:Titanium
D020099:Coated Materials, Biocompatible; C044458:iridium oxide; D007495:Iridium; D014025:Titanium