Cognitive impairment in schizophrenia: its impact on social functioning.
OBJECTIVE
To examine cognitive impairment in schizophrenia and its impact on social functioning.


METHODS
Cohort studies recording cognitive and social development, studies of predictors of poor community outcome, and evidence from brain imaging studies are reviewed.


RESULTS
Executive function deficits, and poor performance in verbal memory, vigilance, and working memory tests are strong predictors of poor community outcome and impairment in skills learning. PET scans of regional cerebral blood flow suggest a dynamic imbalance between different cerebral areas rather than overall loss of brain function.


CONCLUSIONS
Chronic cognitive impairment is the strongest predictor of social disability. Results suggest that the impairment of brain function associated with executive deficits is not necessarily irreversible and may therefore be treatable with appropriate drug therapy.
Liddle
P F
PF
Department of Psychiatry, University of British Columbia, Vancouver, Canada.
D001921:Brain / Q000098:blood supply; D002908:Chronic Disease; D003072:Cognition Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D018492:Dopamine Antagonists / Q000627:therapeutic use; D006801:Humans; D012039:Regional Blood Flow / Q000502:physiology; D012559:Schizophrenia / Q000150:complications*; D012918:Social Alienation; D014055:Tomography, Emission-Computed
D018492:Dopamine Antagonists