Detection of halofantrine, mefloquine and proguanil by charge--transfer complexation on thin layer plates.
A complexation phenomenon between certain antimalarials (as donors) and chloranilic acid (as an acceptor) has been studied using thin-layer-chromatography (TLC). The antimalarials were subjected to charge--transfer complexation using chloranilic acid as the pi-acceptor. This technique was used for the qualitative detection of the drugs. Drug-spotted TLC plates, when developed in suitable solvent systems and sprayed with the pi-acceptor gave a spontaneous purple colour. The Rr values of the three drugs were found to be constant and specific for each drug sample in a particular solvent system.
Adikwu
M U
MU
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Esimone
C O
CO
Attama
A A
AA
Builders
P F
PF
D000962:Antimalarials / Q000032:analysis*; D016227:Benzoquinones; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D015767:Mefloquine / Q000032:analysis*; D010616:Phenanthrenes / Q000032:analysis*; D002727:Proguanil / Q000032:analysis*; D012997:Solvents
D000962:Antimalarials; D016227:Benzoquinones; D007202:Indicators and Reagents; D010616:Phenanthrenes; D012997:Solvents; C023768:halofantrine; D002727:Proguanil; D015767:Mefloquine; C014400:chloranilic acid