title: Cutaneous monomorphous CD4- and CD56-positive large-cell lymphoma.
abstract: BACKGROUND
  Recently, CD56 (NCAM)-positive lymphomas, such as nasal and nasal-type angiocentric NK/T cell lymphoma, aggressive NK cell leukemia/lymphoma and blastic NK cell lymphoma, were described by several authors as a unique group of lymphoma.
  
  
  OBJECTIVE
  In this study, we intend to clarify the clinicopathological features of cutaneous CD4+ and CD56+ lymphoma.
  
  
  METHODS
  Four patients with cutaneous CD4+ and CD56+ lymphoma were studied.
  
  
  RESULTS
  Age at the first examination ranged from 71 to 89 years (mean = 81.2 years). One patient was female and 3 were males. The organ mainly involved at presentation was the skin. Lymphadenopathy, splenomegaly, leukemic spread and central nervous system involvement were observed as the disease progressed. The mean survival time was 12.2 months. Epstein-Barr virus was not detected within the tumor cells.
  
  
  CONCLUSIONS
  This peculiar lymphoma is different from nasal and nasal-type angiocentric NK/T cell lymphoma and aggressive NK cell leukemia/lymphoma. Similar cases have been reported as blastic NK cell lymphoma/leukemia.
authors.affiliation: Department of Dermatology, Yokohama City University Medical Center, Yokohama, Japan. d2674@urahp.yokohama-cu.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nagatani
authors.forename: H
authors.initials: H
authors.lastname: Okazawa
authors.forename: T
authors.initials: T
authors.lastname: Kambara
authors.forename: K
authors.initials: K
authors.lastname: Satoh
authors.forename: H
authors.initials: H
authors.lastname: Tokura
authors.forename: M
authors.initials: M
authors.lastname: Miyazawa
authors.forename: R
authors.initials: R
authors.lastname: Yamada
authors.forename: N
authors.initials: N
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Nakajima
authors.forename: E
authors.initials: E
authors.lastname: Yamazaki
authors.forename: H
authors.initials: H
authors.lastname: Kanamori
authors.forename: H
authors.initials: H
authors.lastname: Mohri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015704:CD4 Antigens / Q000032:analysis*; D019002:CD56 Antigen / Q000032:analysis*; D017809:Fatal Outcome; D005260:Female; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D016694:Gene Rearrangement, delta-Chain T-Cell Antigen Receptor / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000737:chemistry / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D015704:CD4 Antigens; D019002:CD56 Antigen