Peripheral-type benzodiazepine receptors in human blood cells of patients affected by migraine without aura.
The kinetic parameters at equilibrium of peripheral benzodiazepine receptors in platelets, lymphocytes and granulocytes of 15 patients affected by migraine without aura were tested using [3H]PK 11195, a specific radioligand for this receptor and compared with the same number of healthy controls: a statistically significant increase (platelets 212%, lymphocytes 203%, granulocytes 171%, as absolute percentage) in the maximal number of binding sites (B(max)) in all three patient samples, compared with healthy controls was detected; on the contrary, the values of the dissociation constant (K(d)) at equilibrium do not show any statistically significant variations between the two groups. These data further confirm the presence of peripheral biochemical alterations in migraine without aura. As peripheral benzodiazepine receptors appear to be involved in the regulation of the mitochondrial respiratory chain, the observed increase in B(max) might be related to the mitochondrial anomalies found in migraine disorders.
Pavese
N
N
Dipartimento di Neuroscience, Sezione di Neurologia, Pisa, Italy.
Giannaccini
G
G
Betti
L
L
Ferrari
S
S
Bonanni
E
E
Bonuccelli
U
U
Murri
L
L
Lucacchini
A
A
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007546:Isoquinolines / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D020326:Migraine without Aura / Q000097:blood*; D011963:Receptors, GABA-A / Q000097:blood*; D014316:Tritium
D007546:Isoquinolines; D011963:Receptors, GABA-A; D014316:Tritium; C037850:PK 11195