title: Efficient enantioselective synthesis of sertraline, a potent antidepressant, via a novel intramolecular nucleophilic addition to imine.
abstract: [formula: see text] An efficient enantioselective synthesis of sertraline, an antidepressant, utilizing anionic imine ring closure is described.
authors.affiliation: Process Research Department, Merck Research Laboratories, Rahway, New Jersey 07065, USA. cheng_chen@merck.com
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: R A
authors.initials: RA
authors.lastname: Reamer
mesh_terms: D018687:Antidepressive Agents, Second-Generation / Q000138:chemical synthesis*; D007097:Imines / Q000737:chemistry; D020280:Sertraline / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D018687:Antidepressive Agents, Second-Generation; D007097:Imines; D020280:Sertraline