title: Growth inhibitory effects on fall armyworm Spodoptera frugiperda of some limonoids isolated from Cedrela spp. (Meliaceae).
abstract: Dichloromethane extracts of Cedrela salvadorensis and Cedrela dugessi afforded a photogedunin epimeric mixture, gedunin and cedrelanolide. These compounds and the photogedunin epimeric acetates 3 and 4 at the 23-OH position were evaluated against Spodoptera frugiperda. Toosendanin, isolated from Melia azedarach, was used as a positive control. When tested for activity on neonate larvae into the no-choice bioassays, gedunin, photogedunin epimeric mixture, and photogedunin acetates mixture caused significant larval mortality with LC(50) of 39.0, 10.0, and 8.0 ppm at 7 days, respectively, as well as growth reduction. All the compounds tested inhibited larval growth, compared to the control, in a concentration-dependent manner. In addition, it was possible to observe significant reduced pupal weights and adult emergence. All the tested compounds except cedrelanolide showed comparable activity to that of toosendanin.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de Mexico, Ciudad Universitaria, 04510 Mexico D.F., Mexico. ccespede@servidor.unam.mx
authors.forename: C L
authors.initials: CL
authors.lastname: Céspedes
authors.forename: J S
authors.initials: JS
authors.lastname: Calderón
authors.forename: L
authors.initials: L
authors.lastname: Lina
authors.forename: E
authors.initials: E
authors.lastname: Aranda
mesh_terms: D000818:Animals; D001681:Biological Assay; D007605:Juvenile Hormones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D010944:Plants / Q000737:chemistry*; D018411:Spodoptera / Q000187:drug effects* / Q000254:growth & development; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D007605:Juvenile Hormones; D014315:Triterpenes