Alcohol consumption and cigarette smoking in relation to high frequency of p53 protein accumulation in oesophageal squamous cell carcinoma in the Japanese.
We investigated levels of p53 protein expression in Japanese patients with oesophageal squamous cell carcinoma. A significantly larger proportion of heavy alcohol drinkers and cigarette smokers was evident in the p53-positive group. The combination of drinking and smoking was associated with a high frequency of p53 protein accumulation.
Saeki
H
H
The Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Ohno
S
S
Araki
K
K
Egashira
A
A
Kawaguchi
H
H
Ikeda
Y
Y
Morita
M
M
Kitamura
K
K
Sugimachi
K
K
D000428:Alcohol Drinking / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D004938:Esophageal Neoplasms / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D016017:Odds Ratio; D010947:Plants, Toxic; D012907:Smoking / Q000378:metabolism*; D014026:Nicotiana; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53