Chemokine blockade as a therapy for renal disease.
Chemokines have been verified as inflammatory mediators of experimental nephritis by using anti-chemokine antibodies, chemokine receptor antagonists or targeted chemokine gene disruption. In human disease, chemokines are expressed in the kidney in association with inflammatory infiltrates. Chemokine blockade is thus a potentially novel approach to therapy of inflammatory renal disease. Several anti-chemokine strategies are under development. Effective use of anti-chemokine therapy for renal disease will require a precise understanding of the unique roles that individual chemokines have in renal pathology, and the genetic factors that regulate chemokine expression.
Rovin
B H
BH
Department of Medicine, Ohio State University School of Medicine and Public Health, Columbus, USA. rovin.1@osu.edu
D018925:Chemokines / Q000037:antagonists & inhibitors* / Q000235:genetics; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D006801:Humans; D007167:Immunotherapy; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000628:therapy; D007674:Kidney Diseases / Q000235:genetics / Q000628:therapy*
D018925:Chemokines