New rearrangement pattern after treatment of hairy-cell leukemia with 2-chlorodeoxyadenosine.
Leukemic hairy cells are clonally proliferating B-lymphoid cells with clonal rearrangements of genes for immunoglobulin chains. We describe a patient with a new hairy-cell clone after treatment with 2-chlorodeoxyadenosine (2-CdA). In this patient, a single course of 2-CdA resulted in good partial remission of hairy-cell leukemia, but Southern blot analysis of bone marrow biopsies and polymerase chain reaction using seminested amplifications with consensus primers revealed a new rearranged band 4 months after therapy with 2-CdA. Four years after therapy, the patient is in complete clinical remission and both bands disappeared during follow-up. The new rearranged band might have been related to prior treatment of hairy-cell leukemia with 2-CdA.
Schirmer
M
M
Department of Internal Medicine, Leopold Franzens University, Innsbruck, Austria.
Haun
M
M
Grünewald
K
K
Geisen
F
F
Hilbe
W
W
Thaler
J
J
Konwalinka
G
G
D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000473:pathology; D015139:Blotting, Southern; D017338:Cladribine / Q000627:therapeutic use*; D002999:Clone Cells / Q000473:pathology; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D014411:Neoplastic Stem Cells / Q000473:pathology; D012074:Remission Induction
D000964:Antimetabolites, Antineoplastic; D017338:Cladribine