Synthesis of 4,6-dichloro-3-[(1-N-arylaminocarbonyl)-hydrazono]-1,3-dihydro-indole-2 -one as a potential NMDA receptor glycine site antagonist.
A synthetic procedure for the preparation of indole-2,3-dione derivatives 6 as a potential NMDA receptor glycine site antagonist with improved pharmacological profile compared with 2-carboxyindole derivative 5, starting from readily available 3,5-dichloroaniline (7), is described.
Hwang
K J
KJ
Department of Chemistry, and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University, Chonju, Korea. kijun@moak.chonbuk.ac.kr
Lee
T S
TS
D018684:Glycine Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
C412946:4,6-dichloro-3-((1-N-arylaminocarbonyl)-hydrazono)-1,3-dihydro-indole-2-one; D018684:Glycine Agents; D006835:Hydrazones; D007202:Indicators and Reagents; D007211:Indoles; D016194:Receptors, N-Methyl-D-Aspartate