title: Recovery directed left ventricular assist device: a new concept.
abstract: To promote cardiac recovery, we developed a recovery directed left ventricular assist device (RDLVAD) that consists of a valved apical conduit, an afterload controlling chamber (ACC), and a pump. We evaluated its efficacy by comparison with an ordinary LVAD. In each of six pigs with ischemia-induced heart failure, flow and pressure measurements were made while maintaining the total blood flow and arterial pressure equal in the two groups. RDLVAD was able to direct all the blood ejected from the LV into the ACC (0-15 mm Hg) but not into the aorta (73 mm Hg). In the ordinary LVAD, however, some ejection occurred into the aorta despite vigorous suction of the LV. Thus, RDLVAD increased DPTI/SPTI 2.3 times (p < 0.005) and decreased left ventricular end-diastolic pressure by 40% and maximum dP/dt by 20% (p < 0.05). Even the apical valve, at approximately half the diameter of the aortic valve, was able to allow all the blood ejected from the LV to enter the ACC. In one control group pig that achieved almost no ejection into the aorta, left ventricular relaxation and dilatation was extremely limited. RDLVAD may promote cardiac recovery by ensuring less LV work, a greater blood supply/demand ratio in the coronary circulation, and full ventricular relaxation.
authors.affiliation: College of Science and Engineering, Tokyo Denki University, Saitoma, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Miyawaki
authors.forename: T
authors.initials: T
authors.lastname: Tsuji
authors.forename: Y
authors.initials: Y
authors.lastname: Fukui
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002408:Catheters, Indwelling; D003326:Coronary Circulation; D006353:Heart-Assist Devices; D008991:Monitoring, Physiologic; D017202:Myocardial Ischemia / Q000503:physiopathology* / Q000534:rehabilitation / Q000601:surgery*; D020127:Recovery of Function; D013552:Swine; D013556:Swine, Miniature; D014661:Vasoconstriction; D014664:Vasodilation; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology* / Q000534:rehabilitation / Q000601:surgery*