title: Polylactide microspheres for the modified release of corticosteroids.
abstract: A steroidal drug, prednisolone 21-acetate, has been incorporated into polylactide (PDLLA) microspheres using a single emulsion/evaporation technique. This paper describes the method used and the characterization of the microspheres obtained: morphology, particle size distribution, drug content, yield of production and in vitro drug release behaviour.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi di Sassari, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Giunchedi
authors.forename: E
authors.initials: E
authors.lastname: Gavini
authors.forename: B
authors.initials: B
authors.lastname: Conti
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D005079:Excipients; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters; D012995:Solubility
chemical_list: D000305:Adrenal Cortex Hormones; D005079:Excipients; D011091:Polyesters; C033616:poly(lactide)