title: Transthyretin isoleucine-122 mutation in African and American blacks.
abstract: The gene frequency of the transthyretin (TTR) mutation (Val122Ile) was studied in African and African-American populations. The African populations analyzed included the Zulu and Xhosa of South Africa, and Yorubas from the city of Ibadan, Nigeria. The African-American population included patients at the Veterans Affairs (VA) Medical Center, Indianapolis, and newborns from a local hospital in Indianapolis. The Val122Ile TTR mutation was identified in 1 of 55 Zulu, 0 of 34 Xhosa, 0 of 9 Nigerian subjects, 5 of 51 Veteran patients, and 3 of 103 newborns. Assuming the 2.91% prevalence in newborns to be the norm, there is a significant increased prevalence in the VA patient population.
authors.affiliation: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA.
authors.forename: I
authors.initials: I
authors.lastname: Afolabi
authors.forename: K
authors.initials: K
authors.lastname: Hamidi Asl
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: P
authors.initials: P
authors.lastname: Jacobs
authors.forename: H
authors.initials: H
authors.lastname: Hendrie
authors.forename: M D
authors.initials: MD
authors.lastname: Benson
mesh_terms: D000328:Adult; D000349:Africa; D000368:Aged; D044383:Black People; D005260:Female; D006801:Humans; D007532:Isoleucine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011228:Prealbumin / Q000235:genetics*; D014481:United States; D001741:Black or African American
chemical_list: D011228:Prealbumin; D007532:Isoleucine