Linear relation between cerebral phosphocreatine concentration and memory capacities during permanent brain vessel occlusions in rats.
The present study investigates the interrelation between cerebral energy state and memory capacities in a rat model of stepwise cerebral vessel occlusions. After acute and subchronic permanent vessel occlusions, cortical energy metabolites (ATP, phosphocreatine, ADP, AMP) were detected by high-pressure liquid chromatography (HPLC) analysis, and the effects on learning, memory, and cognitive behavior were evaluated using a hole-board test. The results of the study demonstrated a drastic decrease in energy-rich phosphates by 33% for phosphocreatine and by 44% for ATP after acute vessel occlusions. In addition, rat working and reference memories were strikingly decreased to about 5% of controls. In contrast, two weeks after four-vessel occlusion, the energy state was almost completely restored to control levels. However, a significant decrease in memory capacities was observed in subchronic state. In summary, this study has demonstrated a close linear relationship (p < 0.001) between an impaired cerebral energy state and brain memory dysfunction after acute and permanent cerebral four-vessel occlusion. Thus, this animal model of stepwise reduction of the cerebral blood supply may reflect some clinically relevant processes occurring during cerebrovascular and neurodegenerative diseases.
Plaschke
K
K
Anesthesiology Clinic, University of Heidelberg, Germany.
Yun
S W
SW
Martin
E
E
Hoyer
S
S
Bardenheuer
H J
HJ
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism* / Q000523:psychology*; D017536:Carotid Artery, Common; D002540:Cerebral Cortex / Q000378:metabolism; D003071:Cognition; D004564:Electrocoagulation; D004734:Energy Metabolism; D007858:Learning; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014711:Vertebral Artery
D010725:Phosphocreatine; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate