[Hypertension and heart failure. Are there approaches for differential therapy?].
Various pathophysiological mechanisms are involved in the development of heart failure. In addition to interstitial changes, restricted myocardial contractility promotes neuroendocrinial activation which, in turn, can lead to structural changes, thus setting up a vicious circle. In order to prevent manifest cardiac insufficiency from developing, individual treatment determined by symptoms and ventricular function and interfering with this circular chain of events must be administered. Incipient cardiac insufficiency is preferentially treated with ACE inhibitors and AT1-antagonists.
Böhm
M
M
Klinik III für Innere Medizin, Universität zu Köln. MichaelBöhm@Medizin.Uni-Klinik.de
D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D011379:Prognosis
D000959:Antihypertensive Agents; D002316:Cardiotonic Agents