title: Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors.
abstract: We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon alpha/beta receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.
authors.affiliation: Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Oritani
authors.forename: K L
authors.initials: KL
authors.lastname: Medina
authors.forename: Y
authors.initials: Y
authors.lastname: Tomiyama
authors.forename: J
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Okajima
authors.forename: M
authors.initials: M
authors.lastname: Ogawa
authors.forename: T
authors.initials: T
authors.lastname: Yokota
authors.forename: K
authors.initials: K
authors.lastname: Aoyama
authors.forename: I
authors.initials: I
authors.lastname: Takahashi
authors.forename: P W
authors.initials: PW
authors.lastname: Kincade
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism; D002461:Cell Line, Transformed; D003001:Cloning, Molecular; D016207:Cytokines / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006131:Growth Inhibitors / Q000235:genetics / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D050856:Interferon Regulatory Factor-1; D007370:Interferon Type I / Q000737:chemistry; D008565:Membrane Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000378:metabolism; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013154:Spleen / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D016207:Cytokines; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D006131:Growth Inhibitors; C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1; D007370:Interferon Type I; C494258:Irf1 protein, mouse; D008565:Membrane Proteins; D010750:Phosphoproteins; D017471:Receptors, Interferon; C410906:limitin; D053633:Receptor, Interferon alpha-beta