Excessive portal venous supply of long-chain free fatty acids to the liver, leading to hypothalamus-pituitary-adrenal-axis and sympathetic activation as a key to the development of syndrome X. A proposed concept for the induction of syndrome X.
Benthem
L
L
Department of Human Biology, University of Maastricht, The Netherlands. B.Benthem@hb.unimaas.nl
Kuipers
F
F
Steffens
A B
AB
Scheurink
A J
AJ
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D011169:Portal Vein; D013564:Sympathetic Nervous System / Q000378:metabolism / Q000503:physiopathology*
D005230:Fatty Acids, Nonesterified