The use of oral pentobarbital sodium (Nembutal) versus oral chloral hydrate in infants undergoing CT and MR imaging--a pilot study.
BACKGROUND
Chloral hydrate, a commonly used oral sedative for infants undergoing imaging examinations, has a bitter taste and requires relatively large volume, provoking unpleasant reactions from the infants. Experience with an alternative sedative, oral pentobarbital (Nembutal), has not been reported for infants.


OBJECTIVE
To compare patient acceptance of oral Nembutal and oral chloral hydrate for sedation of infants up to 12 months of age.


METHODS
Fifty-four infants (mean age: 7 months) were prospectively enrolled. Parents chose Nembutal, chloral hydrate, or no preference. Thirty-eight infants received Nembutal (4-6 mg/kg) mixed with cherry syrup and 16 received chloral hydrate (50-100 mg/ kg). We recorded infant's acceptance of sedative, parental impression of infant's acceptance, time to sedation, time to discharge, adverse effects, parental preference of future sedative.


RESULTS
Infant acceptance and parental impression were better for Nembutal (P < 0.0001). Fewer parents in the Nembutal group preferred another sedative (P = 0.05). There was a trend toward shorter time to discharge with Nembutal (P = 0.03). There were no adverse effects in either group. One infant failed to sedate with Nembutal.


CONCLUSIONS
Compared with chloral hydrate, oral Nembutal has significantly better acceptance by infants and parents, equal effectiveness, and may result in a shorter time to discharge.
Chung
T
T
Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Hoffer
F A
FA
Connor
L
L
Zurakowski
D
D
Burrows
P E
PE
D000284:Administration, Oral; D002697:Chloral Hydrate / Q000008:administration & dosage*; D016292:Procedural Sedation / Q000379:methods*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010424:Pentobarbital / Q000008:administration & dosage*; D010865:Pilot Projects; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods
D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate; D010424:Pentobarbital