title: Local drug delivery.
abstract: Intensive research efforts are now focused on the development of new strategies for more effective delivery of drugs to the central nervous system. These strategies include chemical modification of drugs, disruption of the blood-brain barrier, and utilization of alternative routes for drug delivery. This paper focuses on local drug delivery for the treatment of brain tumors. It reviews papers published in the past year on local chemotherapy and immunotherapy. Other aspects of local drug delivery are discussed, including convection-enhanced delivery and drug delivery via a controlled-release microchip.
authors.affiliation: Department of Neurological Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: R I
authors.initials: RI
authors.lastname: Haroun
authors.forename: H
authors.initials: H
authors.lastname: Brem
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000628:therapy*; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016503:Drug Delivery Systems; D006801:Humans; D007167:Immunotherapy / Q000379:methods
chemical_list: D000970:Antineoplastic Agents