title: The combination of elastase and sulfur dioxide exposure causes COPD-like lesions in the rat.
authors.affiliation: Pulmonary Toxicology Branch, Experimental Toxicology Division, National Health and Environment Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
authors.forename: U P
authors.initials: UP
authors.lastname: Kodavanti
authors.forename: M C
authors.initials: MC
authors.lastname: Jackson
authors.forename: A D
authors.initials: AD
authors.lastname: Ledbetter
authors.forename: B C
authors.initials: BC
authors.lastname: Starcher
authors.forename: P A
authors.initials: PA
authors.lastname: Evansky
authors.forename: A
authors.initials: A
authors.lastname: Harewood
authors.forename: D W
authors.initials: DW
authors.lastname: Winsett
authors.forename: D L
authors.initials: DL
authors.lastname: Costa
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D002452:Cell Count; D004195:Disease Models, Animal; D004357:Drug Synergism; D007322:Instillation, Drug; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008173:Lung Diseases, Obstructive / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D010196:Pancreatic Elastase / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011914:Rats, Inbred BN; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests; D013458:Sulfur Dioxide / Q000008:administration & dosage / Q000633:toxicity*; D014132:Trachea
chemical_list: D000393:Air Pollutants; D013458:Sulfur Dioxide; D007770:L-Lactate Dehydrogenase; D010196:Pancreatic Elastase