An interleukin-6-producing cardiac myxoma associated with mediastinal lymphadenopathy.
We report our experience with a patient whose mediastinal lymphadenopathy resolved after resection of a cardiac myxoma that secreted interleukin-6 (IL-6). The patient was a 68-year-old female who complained of nocturnal chest discomfort related to congestive heart failure. An echocardiogram demonstrated a large left atrial mass. A computed tomogram showed not only the left atrial mass but multiple enlarged mediastinal lymph nodes. The serum IL-6 level was markedly elevated at 13.7 pg/ml. After resection of the cardiac myxoma, serum IL-6 returned to the normal range. A repeat computed tomogram showed no mediastinal lymphadenopathy. We believe that overproduction of IL-6 by the cardiac myxoma was the cause of the mediastinal lymphadenopathy.
Takizawa
T
T
Cardiovascular Hospital of Central Japan, Hokkitsu-mura.
Sumino
H
H
Kanda
T
T
Kobayashi
I
I
Nagai
R
R
Ichikawa
S
S
D000368:Aged; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008206:Lymphatic Diseases / Q000175:diagnosis / Q000209:etiology*; D008477:Mediastinal Diseases / Q000175:diagnosis / Q000209:etiology*; D009232:Myxoma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D015850:Interleukin-6