title: The reproducibility of polyacrylamide gel dosimetry applied to stereotactic conformal radiotherapy.
abstract: The reproducibility of polyacrylamide gel (PAG) dosimetry has been evaluated when used to verify two radiotherapy treatment plans of increasing complexity. The plans investigated were a three-field coplanar arrangement, using the linac jaws for field shaping, and a four-field, conformal, non-coplanar plan using precision-cast lead alloy shielding blocks. Each treatment was performed three times using phantoms and calibration gels manufactured in-house. Two phantoms were specially designed for this work to aid accurate positioning of the gels for irradiation and imaging. All gels were imaged post-irradiation using a Siemens Vision 1.5T MR scanner. T2 relaxation images were calibrated to absorbed dose distributions using a number of smaller calibration vessels to produce distribution maps of relative dose. The relative dose distributions were found to be reproducible, with the standard deviation on the mean areas enclosed by the > or = 50% isodose lines measured in three orthogonal planes being 6.4% and 4.1% for the coplanar and non-coplanar plans respectively. The measured distributions were also consistent with those planned, with isodose lines generally agreeing to within a few millimetres. However, the measured absolute doses were on average 23.5% higher than those planned. Although the polyacrylamide gel dosimetry technique has some limitations, particularly when calibrating distributions to absolute dose, the ability to resolve sharp dose gradients in three dimensions with millimetre precision is invaluable when verifying complex conformal treatment plans, where avoidance of proximal, critical structures is a treatment criterion.
authors.affiliation: Joint Department of Physics, The Royal Marsden NHS Trust, Sutton, Surrey, UK. vivian@icr.ac.uk
authors.forename: V P
authors.initials: VP
authors.lastname: Cosgrove
authors.forename: P S
authors.initials: PS
authors.lastname: Murphy
authors.forename: M
authors.initials: M
authors.lastname: McJury
authors.forename: E J
authors.initials: EJ
authors.lastname: Adams
authors.forename: A P
authors.initials: AP
authors.lastname: Warrington
authors.forename: M O
authors.initials: MO
authors.lastname: Leach
authors.forename: S
authors.initials: S
authors.lastname: Webb
mesh_terms: D000180:Acrylic Resins; D055592:Biophysical Phenomena; D001703:Biophysics; D004867:Equipment Design; D005782:Gels; D006801:Humans; D008279:Magnetic Resonance Imaging; D009369:Neoplasms / Q000532:radiotherapy; D019047:Phantoms, Imaging; D011874:Radiometry / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal / Q000379:methods*; D015203:Reproducibility of Results; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D005782:Gels; D000099166:Polyacrylamides