Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors.
We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon alpha/beta receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.
Oritani
K
K
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
Medina
K L
KL
Tomiyama
Y
Y
Ishikawa
J
J
Okajima
Y
Y
Ogawa
M
M
Yokota
T
T
Aoyama
K
K
Takahashi
I
I
Kincade
P W
PW
Matsuzawa
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D001483:Base Sequence; D001853:Bone Marrow / Q000378:metabolism; D002461:Cell Line, Transformed; D003001:Cloning, Molecular; D016207:Cytokines / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006131:Growth Inhibitors / Q000235:genetics / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D050856:Interferon Regulatory Factor-1; D007370:Interferon Type I / Q000737:chemistry; D008565:Membrane Proteins; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000378:metabolism; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013154:Spleen / Q000378:metabolism; D014407:Tumor Cells, Cultured
D016207:Cytokines; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D006131:Growth Inhibitors; C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1; D007370:Interferon Type I; C494258:Irf1 protein, mouse; D008565:Membrane Proteins; D010750:Phosphoproteins; D017471:Receptors, Interferon; C410906:limitin; D053633:Receptor, Interferon alpha-beta