title: Isolation of the antiulcer compound in essential oil from the leaves of Cryptomeria japonica.
abstract: Essential oil from the leaves of Tateyamasugi (Cryptomeria japonica) exhibited strong inhibitory activity on ulceration induced by HCl/ethanol, HCl/aspirin, water-immersion stress and pylorus-ligation. We separated the antiulcer compounds from cedar essential oil by use of distillation and chromatography. As a result, terpinen-4-ol, a monoterpene, and elemol, a sesquiterpene, were isolated as active compounds. The antiulcer activity of the former was more potent than that of the latter. Terpinen-4-ol was a mixture of optical isomers and each possessed potent antiulcer activity. Secretion of gastric juice and output of acid and pepsin activity were lowered by terpinen-4-ol. These results suggest that terpinen-4-ol isolated from cedar essential oil could be a valuable antiulcer agent.
authors.affiliation: Toyama Prefectural Institute for Pharmaceutical Research, Imizu, Japan. takayuki.matsunaga@tak.pref.toyama.jp
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
authors.forename: C
authors.initials: C
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Kawasuji
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Sagioka
authors.forename: R
authors.initials: R
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: T
authors.initials: T
authors.lastname: Morikawa
authors.forename: T
authors.initials: T
authors.lastname: Akiyama
mesh_terms: D000079:Acetaldehyde; D000818:Animals; D000897:Anti-Ulcer Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D001241:Aspirin; D032462:Cycadopsida / Q000737:chemistry*; D004195:Disease Models, Animal; D005750:Gastric Juice / Q000378:metabolism; D006851:Hydrochloric Acid; D008297:Male; D009822:Oils, Volatile / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013729:Terpenes / Q000302:isolation & purification* / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D009822:Oils, Volatile; D013729:Terpenes; C034019:terpinenol-4; D000079:Acetaldehyde; D006851:Hydrochloric Acid; D001241:Aspirin