title: [Hepatotoxicity by amoxicillin/clavulanic acid: case report].
abstract: We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal < 35 U/L), alanine aminotransferase 470 U/L (normal < 40) and alkaline phosphatases of 400 U/L (normal < 100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis.
authors.affiliation: Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile.
authors.forename: A
authors.initials: A
authors.lastname: Soza
authors.forename: F
authors.initials: F
authors.lastname: Riquelme
authors.forename: M
authors.initials: M
authors.lastname: Alvarez
authors.forename: I
authors.initials: I
authors.lastname: Duarte
authors.forename: J C
authors.initials: JC
authors.lastname: Glasinovic
authors.forename: M
authors.initials: M
authors.lastname: Arrese
mesh_terms: D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use
chemical_list: D002756:Cholagogues and Choleretics; D014580:Ursodeoxycholic Acid; D019980:Amoxicillin-Potassium Clavulanate Combination