A new class of highly cytotoxic diketopiperazines.
The discovery of a novel class of diketopiperazines possessing potent cytotoxic activity is described.
Boger
D L
DL
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. boger@scripps.edu
Fink
B E
BE
Hedrick
M P
MP
D000818:Animals; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007211:Indoles / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D010879:Piperazines / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C413725:3,9-bis(dimethylaminopropanoyl)piperazino(1,2-a - 5,4-a')diindole-6,12-dione; D007211:Indoles; D010879:Piperazines; D004247:DNA