title: Is there a possible role for haemostasis in the development of perigraft reaction complicating the modified Blalock Taussig shunt?
abstract: The perigraft reaction is an unusual complication found in patients in whom a modified Blalock Taussig shunt has been created using a polytetrafluoroethylene graft. We found that, in two infants, consistent laboratory findings during such a perigraft reaction were hypofibrinogenemia, increased levels of thrombin-antithrombin III complex, prothrombin fragment 1 and 2 and products of degradation of fibrin. Normalization of the levels of fibrinogen produced resolution of the perigraft reaction.
authors.affiliation: Department of Pediatric Cardiology, General Hospital Vienna, University of Vienna, Austria. ulrike.salzer@akh-wien.ac.at
authors.forename: U
authors.initials: U
authors.lastname: Salzer-Muhar
authors.forename: I
authors.initials: I
authors.lastname: Pabinger-Fasching
authors.forename: S
authors.initials: S
authors.lastname: Zacherl-Wightman
mesh_terms: D001672:Biocompatible Materials; D001778:Blood Coagulation Disorders / Q000209:etiology / Q000517:prevention & control*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods; D015150:Echocardiography, Doppler; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000209:etiology / Q000517:prevention & control*; D006085:Graft Survival; D006489:Hemostatic Techniques; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011138:Polytetrafluoroethylene; D013771:Tetralogy of Fallot / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D005343:Fibrinolytic Agents; D011138:Polytetrafluoroethylene