Epithelial transcytosis of immunoglobulins.
Transcytosis plays a central role in the immunological functions of epithelia, including the sampling of antigens that enter the body via the digestive, respiratory and urogenital tracts and their presentation to underlying lymphoid tissues, the secretion of specific immunoglobulins required for the immune protection of mucosal surfaces and the transfer of maternal immunoglobulins to the fetus or newborn, providing the latter with passive immunity for the first weeks of independent life.
Hunziker
W
W
Institute of Biochemistry, University of Lausanne, BIL Research Center, Epalinges, Switzerland. Walter.Hunziker@ib.unil.ch
Kraehenbuhl
J P
JP
D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D004847:Epithelial Cells / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D018928:Immunity, Mucosal; D007071:Immunoglobulin A, Secretory / Q000502:physiology; D007136:Immunoglobulins / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000502:physiology; D008969:Molecular Sequence Data; D009092:Mucous Membrane / Q000276:immunology; D011247:Pregnancy; D019056:Receptors, Polymeric Immunoglobulin / Q000737:chemistry / Q000502:physiology
D007071:Immunoglobulin A, Secretory; D007136:Immunoglobulins; D019056:Receptors, Polymeric Immunoglobulin