LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors.
A number of unusual seven-transmembrane molecules have recently been characterized that have significant amino acid sequence similarity within the membrane-spanning hydrophobic regions and intervening loops to members of G-protein-coupled receptor family B. However, in contrast to the family-B G-protein-coupled receptors, these molecules have unusually large N-terminal extracellular domains that contain a number of well- characterized protein modules. The range of cell types expressing these complex molecules and their potential roles in cell adhesion and signalling have become a major focus of research in a number of biological systems.
Stacey
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Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE.
Lin
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Gordon
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McKnight
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D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion; D002462:Cell Membrane / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D011956:Receptors, Cell Surface / Q000737:chemistry* / Q000145:classification; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D011956:Receptors, Cell Surface