Quantifying leukocyte and thrombocyte suppression-recovery after Re-186 HEDP for bone metastases.
Using a standard quantity of Re-186 HEDP, for therapy of osseous metastases from carcinoma of the breast, Palmedo and associates reported leukocyte and thrombocyte responses at 4 and 8 weeks. These were analyzed by dividing results into categories, based on the numeric initial values. Thrombocytes at 8 weeks exceeded pretreatment values in 10 of 18 cases. This "over-rebound" was also found in 7 of 19 leukocyte responses. The ability to predict thrombocyte-leukocyte response, in most cases, was linked to the initial hematologic values. If coupled with data on the status of bone marrow, this may allow the quantity of therapeutic radiopharmaceutical used to be increased or decreased without irreversibly compromising hematopoietic responses.
Spencer
R P
RP
Division of Nuclear Medicine, Diagnostic Imaging and Therapeutics, University of Connecticut Health Center, Farmington 06030-2804, USA. Rspencer@adp.uchc.edu
D001792:Blood Platelets / Q000528:radiation effects*; D001853:Bone Marrow / Q000528:radiation effects; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D002277:Carcinoma / Q000532:radiotherapy / Q000556:secondary*; D012968:Etidronic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000528:radiation effects*; D007970:Leukopenia / Q000145:classification* / Q000503:physiopathology; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D010976:Platelet Count; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000627:therapeutic use*; D012211:Rhenium / Q000008:administration & dosage / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000145:classification* / Q000503:physiopathology; D014004:Tin Radioisotopes / Q000008:administration & dosage / Q000627:therapeutic use*
D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D014004:Tin Radioisotopes; C064573:rhenium-186(tin)etidronate; D012211:Rhenium; D012968:Etidronic Acid