title: Methods for separation of contributions from two radionuclides in autoradiography with a silicon strip detector.
abstract: Two methods have been developed for the separation of contributions from two different nuclides in an autoradiography picture. Both approaches, a modified least squares (LS) and a maximum likelihood (ML) algorithm, are based on the position and energy information available from a digital detector. Tests and comparisons, using artificially as well as measured data, demonstrate that the ML approach performs slightly better, but is much more computationally demanding than the LS method.
authors.affiliation: Department of Nuclear Medicine, The Norwegian Radium Hospital, Oslo.
authors.forename: Y
authors.initials: Y
authors.lastname: Kvinnsland
authors.forename: A
authors.initials: A
authors.lastname: Skretting
mesh_terms: D000465:Algorithms; D000818:Animals; D001345:Autoradiography / Q000379:methods* / Q000706:statistics & numerical data; D055592:Biophysical Phenomena; D001703:Biophysics; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000706:statistics & numerical data; D016018:Least-Squares Analysis; D016013:Likelihood Functions; D010761:Phosphorus Radioisotopes; D012825:Silicon; D013462:Sulfur Radioisotopes
chemical_list: D010761:Phosphorus Radioisotopes; D013462:Sulfur Radioisotopes; D012825:Silicon