Establishment and characterization of the MSKR inbred strain originated from Japanese wild mice (Mus musculus molossinus).
A new inbred strain, MSKR, originated from Japanese wild mice was established in April, 1998. The MSKR mice were 60% of the C57BL/6N inbred mice in the 60-day body weight. Tail length/head-body length and hind-foot length/head-body length of the MSKR mice were significantly smaller than those of the C57BL/6N mice (0.896 vs 1.061, 0.189 vs 0.204), but ear length/head-body length of the MSKR mice was significantly larger than that of the C57BL/6N mice (0.143 vs 0.137). The age of the first parturition and size of the first litter were 63.20 +/- 2.71 days and 6.20 +/- 0.37, respectively, at the 20th and 22nd inbreeding generations. Genetic characterization of the MSKR strain was performed using 34 microsatellite markers, 29 biochemical markers, 9 immunogenetic markers, 3 coat color markers, and mitochondrial DNA RFLP-haplotypes. The result indicated that this newly established inbred strain has some different gene constitution from already known molossinus and common laboratory strains.
Wada
A
A
Department of Laboratory Animal Science, College of Agriculture, Osaka Prefecture University, Sakai, Japan.
Kakizoe-Ishida
Y
Y
Katoh
H
H
Muguruma
K
K
Ebukuro
M
M
Okumoto
M
M
Tsudzuki
M
M
D000818:Animals; D001835:Body Weight; D005838:Genotype; D006200:Hair Color / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008817:Mice, Mutant Strains / Q000033:anatomy & histology* / Q000235:genetics / Q000502:physiology; D018895:Microsatellite Repeats