Detection of the interleukin 18 family in rat brain by RT-PCR.
Interleukin 18, an inflammatory cytokine, mediates its effects by interaction with its receptor complex, consisting of the IL-18 receptor (IL-18R) and receptor accessory protein (AcPL). A functional inhibitor of IL-18, the IL-18 binding protein (IL-18BP), has been identified recently. This study reports the detection of IL-18, IL-18R, AcPL and IL-18BP mRNA expression in the brain of normal adult rats using RT-PCR.
Wheeler
R D
RD
School of Biological Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, M13 9PT, Manchester, UK.
Culhane
A C
AC
Hall
M D
MD
Pickering-Brown
S
S
Rothwell
N J
NJ
Luheshi
G N
GN
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006023:Glycoproteins / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18 / Q000235:genetics*; D053728:Interleukin-18 Receptor beta Subunit; D008297:Male; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D018123:Receptors, Interleukin / Q000235:genetics*; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D053724:Receptors, Interleukin-18; D020133:Reverse Transcriptase Polymerase Chain Reaction
D006023:Glycoproteins; C486426:Il18rap protein, rat; D036341:Intercellular Signaling Peptides and Proteins; D020382:Interleukin-18; D053728:Interleukin-18 Receptor beta Subunit; D012333:RNA, Messenger; D018123:Receptors, Interleukin; D017472:Receptors, Interleukin-1; D053724:Receptors, Interleukin-18; C118370:interleukin-18 binding protein