title: Combination therapies for HIV and sexual risk behavior among gay men.
abstract: OBJECTIVE
  To examine optimism in the light of recent advances in HIV treatment among gay men and its association with sexual risk behavior.
  
  
  METHODS
  An anonymous questionnaire was completed by gay men who visited gyms in central London in March and April 1998 regarding their HIV status, unprotected anal intercourse (UAI) in the previous 3 months, and their response on a five-point linear scale to two measures of optimism: "I am less worried about HIV now that treatments have improved," and "I believe that new drug therapies make people with HIV less infectious."
  
  
  RESULTS
  Two thirds of the men (67.5%, 522 of 773) did not agree with the statement, "I am less worried about HIV now that treatments have improved," and only 42 (5.4%) said they agreed quite a lot or a lot. HIV-positive men were more likely to agree with this statement than HIV-negative men (p = .001) and men who had never been tested (p < .001). There was no association between agreement with this statement and frequency of UAI among HIV-positive or never-tested men (p > .3); there was, however, a positive association among HIV-negative men who reported UAI with a partner of unknown or discordant status (p = .003). The vast majority of men (81.4%; 634 of 779) did not agree with the statement, "I believe that new drug therapies make people with HIV less infectious." Regardless of HIV status, no significant association was seen between agreement with this statement and frequency of UAI (p > .1 for all comparisons).
  
  
  CONCLUSIONS
  Most gay men surveyed in central London gyms did not endorse the optimism statements concerning improved treatments or reduced infectivity. Although HIV-positive gay men were more likely to be optimistic than other men, there was no association between their optimism and sexual risk behavior. Among HIV-negative men, optimism around improved treatments (but not around reduced infectivity) was associated with UAI with a partner of unknown or discordant HIV status. For some HIV-negative men in London, optimism in the light of recent advances in HIV treatment may have triggered, or have been used as a justification for, sexual risk-taking.
authors.affiliation: Department of Primary Care and Population Sciences and Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, University College London, UK. elford@rfhsm.ac.uk
authors.forename: J
authors.initials: J
authors.lastname: Elford
authors.forename: G
authors.initials: G
authors.lastname: Bolding
authors.forename: M
authors.initials: M
authors.lastname: Maguire
authors.forename: L
authors.initials: L
authors.lastname: Sherr
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy / Q000523:psychology*; D018451:Homosexuality, Male / Q000523:psychology; D006801:Humans; D008131:London; D008297:Male; D012309:Risk-Taking; D012725:Sexual Behavior / Q000523:psychology; D011795:Surveys and Questionnaires