title: First pharmacophoric hypothesis for 5-HT7 antagonism.
abstract: In order to make the first contribution to the elucidation of essential structural features for 5-HT7 antagonism, a set of thirty 5-HT7 antagonists were selected from the literature. A pharmacophore model was built using Molecular Modeling studies with Catalyst program. The information contained in this model was validated with new synthesized compounds.
authors.affiliation: Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, Madrid, Spain. mluzlr@eucmax.sim.ucm.es
authors.forename: M L
authors.initials: ML
authors.lastname: López-Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Porras
authors.forename: B
authors.initials: B
authors.lastname: Benhamú
authors.forename: J A
authors.initials: JA
authors.lastname: Ramos
authors.forename: M J
authors.initials: MJ
authors.lastname: Morcillo
authors.forename: J L
authors.initials: JL
authors.lastname: Lavandera
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008958:Models, Molecular; D051381:Rats; D011985:Receptors, Serotonin / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D015203:Reproducibility of Results; D012702:Serotonin Antagonists / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C104425:serotonin 7 receptor