title: Leptin expression in offspring is programmed by nutrition in pregnancy.
abstract: Birth weight is a determinant of blood leptin concentrations in adults. Since nutrition during pregnancy can affect birth weight, the hypothesis that feed intake during pregnancy alters leptin expression in progeny was examined. Leptin mRNA was measured in subcutaneous adipose tissue and leptin protein was measuredin blood plasma from 59 day old female pigs whose mothers were fed at the same restricted rate except that half were permitted to consume 35% more feed during the second quarter of pregnancy. Leptin mRNA abundance in adipose tissue (P=0.015) and plasma leptin concentration (P=0.01) were higher in progeny from mothers provided with more feed. Body weight at birth was negatively correlated with the abundance of leptin mRNA in subcutaneous fat at 59 days of age (P=0.01). This study shows for the first time that maternal nutrition during pregnancy programs postnatal leptin expression in offspring.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide 5005, Australia.
authors.forename: J E
authors.initials: JE
authors.lastname: Eckert
authors.forename: K L
authors.initials: KL
authors.lastname: Gatford
authors.forename: B G
authors.initials: BG
authors.lastname: Luxford
authors.forename: R G
authors.initials: RG
authors.lastname: Campbell
authors.forename: P C
authors.initials: PC
authors.lastname: Owens
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001724:Birth Weight / Q000502:physiology; D005260:Female; D020738:Leptin / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011297:Prenatal Exposure Delayed Effects; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D020738:Leptin; D012333:RNA, Messenger