Unilateral involuntary movement associated with streptococcal infection: neurophysiological investigation.
Two boys developed rhythmic involuntary movements in the extremities on one side of the body after febrile illness. They also showed behavioral disturbances. In both patients, serum antistreptolysin-O and antistreptokinase titers were elevated in acute illness and decreased a few months later. One patient showed tremorous movement, and the other choreiform movement. In the former, a surface EMG showed short-duration (30 to 60 ms), highly frequent (6 to 8 Hz) and synchronous discharges of multiple muscles, including the antagonists, suggesting myoclonic jerk. In the latter, a surface EMG showed long-duration (0.5 to 1 s), repetitive (about 0.5 Hz) and synchronous or asynchronous discharges of the antagonists, suggesting choreoathetosis. In both patients, giant somatosensory evoked potentials and high-voltage slow EEG activities were observed predominantly in the hemisphere contralateral to the involuntary movement. In the myoclonic patient, long-latency EMG responses were enhanced and cortical potentials preceding the myoclonus were present by jerk-locked back averaging technique. The present data suggest that unilateral rhythmic involuntary movements occur secondary to streptococcal infection. The pathophysiology of the involuntary movements may be associated with sensorimotor cortex hyperexcitability.
Maegaki
Y
Y
Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan. maegaki@grape.med.tottori-u.ac.jp
Akaboshi
S
S
Inagaki
M
M
Takeshita
K
K
D002648:Child; D002819:Chorea / Q000503:physiopathology*; D003952:Diagnostic Imaging; D004292:Dominance, Cerebral / Q000502:physiology*; D004569:Electroencephalography; D004576:Electromyography; D004831:Epilepsies, Myoclonic / Q000503:physiopathology*; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005684:Gait / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation; D012815:Signal Processing, Computer-Assisted; D013003:Somatosensory Cortex / Q000503:physiopathology; D013290:Streptococcal Infections / Q000503:physiopathology*