title: [Utility of Ringer's acetate solution as an intraoperative fluid during cardiovascular surgery with cardiopulmonary bypass].
abstract: This study aimed to clarify the difference in the effects of Ringer's acetate (AR) and Ringer's lactate (LR) administration during cardiovascular surgery with cardiopulmonary bypass. We evaluated their effects on intra and postoperative metabolism, liver functions, blood gas and hemodynamic states. Twenty patients were divided into two groups; AR group (n = 10) and LR group (n = 10). Intraoperative serum D-lactate levels in LR group were significantly higher than those in AR group from the beginning of the operation to awakening. Serum acetate levels showed no increase in both groups. The arterial ketone body ratio (AKBR) in AR group was higher than that in LR group, but the difference was not significant. Serum glutamic pyruvic transaminase (GPT) and alkaline phosphatase (ALP) levels in LR group were significantly higher than those in AR group from the induction of the anesthesia. It has been reported that acetate has a greater vasodialatory effect than lactate. However, our findings indicate no significant difference in hemodynamics between the two groups. These results suggest that AR may be more useful than LR during cardiovascular surgery with cardiopulmonary bypass.
authors.affiliation: Department of Anesthesia, Omiya Medical Center, Jichi Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: H
authors.initials: H
authors.lastname: Sunagawa
authors.forename: N
authors.initials: N
authors.lastname: Futagami
authors.forename: Y
authors.initials: Y
authors.lastname: Ohtsuka
authors.forename: S
authors.initials: S
authors.lastname: Inada
authors.forename: K
authors.initials: K
authors.lastname: Nomoto
authors.forename: M
authors.initials: M
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Murayama
authors.forename: N
authors.initials: N
authors.lastname: Momose
authors.forename: N
authors.initials: N
authors.lastname: Seo
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass; D013504:Cardiovascular Surgical Procedures; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007430:Intraoperative Care; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D000077325:Ringer's Lactate
chemical_list: D007552:Isotonic Solutions; D000077325:Ringer's Lactate; C028570:Ringer's acetate