title: Lateral gene transfer and the nature of bacterial innovation.
abstract: Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through the acquisition of sequences from distantly related organisms. Horizontal gene transfer produces extremely dynamic genomes in which substantial amounts of DNA are introduced into and deleted from the chromosome. These lateral transfers have effectively changed the ecological and pathogenic character of bacterial species.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Arizona, Tucson 85721-0088, USA.
authors.forename: H
authors.initials: H
authors.lastname: Ochman
authors.forename: J G
authors.initials: JG
authors.lastname: Lawrence
authors.forename: E A
authors.initials: EA
authors.lastname: Groisman
mesh_terms: D001419:Bacteria / Q000235:genetics*; D001435:Bacteriophages / Q000235:genetics; D003227:Conjugation, Genetic; D004269:DNA, Bacterial; D004352:Drug Resistance, Microbial / Q000235:genetics; D019143:Evolution, Molecular; D005798:Genes, Bacterial; D011995:Recombination, Genetic; D014169:Transformation, Bacterial; D014774:Virulence / Q000235:genetics
chemical_list: D004269:DNA, Bacterial