title: Acute fuel selection in response to high-sucrose and high-starch meals in healthy men.
abstract: BACKGROUND
  Despite considerable controversy over the inclusion of sucrose in the diets of people with diabetes, the acute metabolism of sucrose is not completely understood.
  
  
  OBJECTIVE
  Our objective was to investigate the metabolism of the monomeric constituents of sucrose after a high-sucrose meal.
  
  
  METHODS
  Three test meals were consumed in a randomized, crossover design by 7 healthy male volunteers. Two of the meals were high in sucrose; one was supplemented with 200 mg uniformly labeled [13C]fructose and one was supplemented with 200 mg [13C]glucose. The other meal was high in starch, supplemented with 200 mg [13C]glucose. Fifty percent of energy was supplied as sucrose in the high-sucrose meals and as starch in the high-starch meal. Breath (13)CO(2) enrichment was measured at 15-min intervals and indirect calorimetry was performed for five 20-min sessions immediately before and during a 6-h postprandial period.
  
  
  RESULTS
  Carbohydrate oxidation rates rose much faster after the high-sucrose meals than after the high-starch meal. Breath (13)CO(2) enrichment rose faster and peaked earlier and at a higher value when [13C]fructose rather than [13C]glucose was given with the high-sucrose test meal. Values for breath (13)CO(2) enrichment from [13C]glucose after the high-starch meal were intermediate.
  
  
  CONCLUSIONS
  These results show that fructose is preferentially oxidized compared with glucose after a high-sucrose meal and that glucose is oxidized more slowly after a high-sucrose meal than after a high-starch meal.
authors.affiliation: Human Nutrition Research Centre, the Department of Biological and Nutritional Sciences, the Human Diabetes and Metabolism Research Centre, and the Department of Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.
authors.forename: M E
authors.initials: ME
authors.lastname: Daly
authors.forename: C
authors.initials: C
authors.lastname: Vale
authors.forename: M
authors.initials: M
authors.lastname: Walker
authors.forename: A
authors.initials: A
authors.lastname: Littlefield
authors.forename: K
authors.initials: K
authors.lastname: George
authors.forename: M
authors.initials: M
authors.lastname: Alberti
authors.forename: J
authors.initials: J
authors.lastname: Mathers
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D019422:Dietary Sucrose / Q000008:administration & dosage* / Q000378:metabolism*; D004734:Energy Metabolism; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D013213:Starch / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D002247:Carbon Isotopes; D004040:Dietary Carbohydrates; D019422:Dietary Sucrose; D002245:Carbon Dioxide; D005632:Fructose; D013213:Starch; D005947:Glucose