title: [The clinical response to interferon-gamma in a patient with chronic granulomatous disease and brain abscesses due to Aspergillus fumigatus].
abstract: Chronic granulomatous disease (CGD) is an heterogeneous inherited disorder where the microbicidal phagocytic properties of leukocytes are impaired. Patients with CGD are prone to severe ious with many microorganisms such as Aspergillus spp (1,2). Recently, interferon gamma (IFN-8) which significantly reduces the frequency of infections in these patients, has been proved useful (3,4). We present our experience with the clinical use of these cytoscine. A 26-year-old woman with CGD suffered recement multiple brain abscesses by Aspergillus fumigatus treated in many occasions with surgical drainage. Since treatment with IFN-8 was started, two years ago, she is well and asymptomatic until the moment.
authors.affiliation: Unidad de Enfermedades Infecciosas, Complejo Hospitalario Xeral-Cies, Facultad de Medicina de Santiago, Vigo.
authors.forename: F
authors.initials: F
authors.lastname: Touza Rey
authors.forename: C
authors.initials: C
authors.lastname: Martínez Vázquez
authors.forename: J
authors.initials: J
authors.lastname: Alonso Alonso
authors.forename: M J
authors.initials: MJ
authors.lastname: Méndez Piñeiro
authors.forename: M
authors.initials: M
authors.lastname: Rubianes González
authors.forename: M
authors.initials: M
authors.lastname: Crespo Casal
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy*; D001232:Aspergillus fumigatus; D001922:Brain Abscess / Q000188:drug therapy*; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy*; D006801:Humans; D007371:Interferon-gamma / Q000008:administration & dosage*; D017964:Itraconazole / Q000008:administration & dosage; D012008:Recurrence
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D007371:Interferon-gamma