Prophylaxis against respiratory syncytial virus in high-risk infants: administration of immune globulin and epidemiological surveillance of infection.
Hospitalizations secondary to respiratory syncytial virus (RSV) infection in children were monitored before and after the administration of RSV immune globulin. Monitored also was the effectiveness of prophylaxis in preventing the disease among at-risk children along the Texas-Mexico border. Small premature infants were at the greatest risk of hospitalization; preterm infants and then term infants followed. Prophylaxis does not necessarily prevent RSV bronchiolitis but may reduce the severity of the pulmonary disease.
Handal
G
G
Department of Pediatrics, Texas Tech University Health Sciences Center at El Paso 79905-2700, USA.
Logvinoff
M M
MM
Zegarra
N
N
Allen
L
L
Jesurun
A
A
Levin
G
G
Thida
A
A
D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology / Q000517:prevention & control; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology / Q000517:prevention & control*; D012136:Respiratory Syncytial Viruses; D013781:Texas / Q000453:epidemiology
D016756:Immunoglobulins, Intravenous; C098685:respiratory syncytial virus immune globulin intravenous