title: Effects of isoflurane, sevoflurane and propofol anaesthesia on jugular venous oxygen saturation in patients undergoing coronary artery bypass surgery.
abstract: We investigated the effect of sevoflurane, isoflurane and propofol on jugular venous bulb oxygen saturation (SjO2) in 21 patients undergoing coronary artery bypass graft surgery (CABG) during and after normothermic cardiopulmonary bypass (CPB). Patients received a standardized anaesthetic consisting of fentanyl, midazolam and were then randomly allocated to receive either isoflurane, sevoflurane or propofol for maintenance. SjO2 values were significantly lower than baseline 1 h after CPB in the propofol but not the isoflurane or the sevoflurane groups. Furthermore, SjO2 values were significantly higher during CPB in the isoflurane group (P = 0.0081) and significantly lower 6 h after CPB in the sevoflurane group (P = 0.0447) when compared to the propofol group. We conclude that jugular venous desaturation during and after normothermic CPB is more likely during propofol anaesthesia.
authors.affiliation: Department of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, UK.
authors.forename: K
authors.initials: K
authors.lastname: Nandate
authors.forename: A
authors.initials: A
authors.lastname: Vuylsteke
authors.forename: I
authors.initials: I
authors.lastname: Ratsep
authors.forename: S
authors.initials: S
authors.lastname: Messahel
authors.forename: A
authors.initials: A
authors.lastname: Oduro-Dominah
authors.forename: D K
authors.initials: DK
authors.lastname: Menon
authors.forename: B F
authors.initials: BF
authors.lastname: Matta
mesh_terms: D000704:Analysis of Variance; D018681:Anesthetics, General / Q000494:pharmacology*; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass / Q000379:methods; D004987:Ethers / Q000494:pharmacology*; D006801:Humans; D007530:Isoflurane / Q000494:pharmacology*; D007601:Jugular Veins; D010092:Oximetry; D010100:Oxygen / Q000097:blood*; D015742:Propofol / Q000494:pharmacology*
chemical_list: D018681:Anesthetics, General; D004987:Ethers; D007530:Isoflurane; D010100:Oxygen; D015742:Propofol