Parvovirus B19 causing leucopenia and neutropenia in a healthy adult.
A 27-year-old healthy female presented with a prolonged and intermittent febrile illness. She was found to have leucopenia, neutropenia and thrombocytopenia, but a normal haemoglobin. The patient recovered spontaneously and convalescent serology 1 month later was positive for specific parvovirus B19 IgM and IgG. Parvovirus B19 infection was confirmed by detection of viral DNA by dot blot hybridization in a specimen of blood taken during the acute illness. A review of the previously reported cases of parvovirus B19-induced leucopenia in normal adults is presented. Parvovirus B19 should be considered in the differential diagnosis of leucopenia and neutropenia in healthy adults.
Barlow
G D
GD
Dept. of Infectious Diseases and Tropical Medicine, Royal Hallamshire Hospital, Sheffield, UK.
McKendrick
M W
MW
D000328:Adult; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000209:etiology*; D008297:Male; D009503:Neutropenia / Q000209:etiology*; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification*