Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-beta?
Interferon-beta1b treatment in relapsing-remitting multiple sclerosis can frequently induce systemic side effects such as flu-like symptoms with fever. In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever generally have increased levels of interleukin-6.
Montalban
X
X
Unitat de Neuroimmunologia Clínica, Servei de Neurologia, Hospital General Universitari Vall d'Hebron, Barcelona, Spain. xmontal@hg.vhebron.es
Durán
I
I
Río
J
J
Sáez-Torres
I
I
Tintoré
M
M
Martínez-Cáceres
E M
EM
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D066298:In Vitro Techniques; D007251:Influenza, Human / Q000150:complications*; D016899:Interferon-beta / Q000627:therapeutic use*; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D016899:Interferon-beta