[The effect of reaferon on the level of catecholamines and mitochondrial enzymes in the ischemic kidney].
The effect of reaferon (introduced at a dose of 1 x 10(6) IU/kg over six days prior to ischemia induction) on the levels of catecholamines and the activity of succinate dehydrogenase and NADH-dehydrogenase in various structures of kidney was studied in experiments on white rats. The ischemia was modeled by 90-min ligation of renal vessels. Reaferon retained the luminescence of catecholamines in all renal structures 24 h after circulation was restored on the level of intact kidney, except for the nerve trunks where the luminescence intensity decreased by 40%. Preliminary introduction of reaferon stimulated restoration of the enzymatic activity in the Krebs cycle and mitochondrial respiratory chain after 24- and 48-h revascularization, respectively.
Vorob'eva
N D
ND
Pharmacology Chair, Chuvash State University, Cheboksary, Russia.
Anikin
G D
GD
Karyshev
P B
PB
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D002952:Citric Acid Cycle / Q000187:drug effects; D007370:Interferon Type I / Q000494:pharmacology*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007511:Ischemia / Q000378:metabolism*; D007668:Kidney / Q000098:blood supply* / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009245:NADH Dehydrogenase / Q000187:drug effects; D051381:Rats; D011994:Recombinant Proteins; D013385:Succinate Dehydrogenase / Q000187:drug effects; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D002395:Catecholamines; D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase