title: Primary non-Hodgkin's lymphoma of the jaws: immunohistochemical and genetic review of 10 cases.
abstract: OBJECTIVE
  Non-Hodgkin's lymphoma (NHL) comprises a group of malignant lymphoproliferative diseases characterized by clonal expansion of lymphocytes at various levels of ontogenetic development. The aim of this study was to review the immunohistochemical and cytogenetic features of 10 cases of NLH of the jaws to determine their respective derivation.
  
  
  METHODS
  Histopathologic and immunohistochemical review of 10 cases of large-cell lymphomas of the jaws, together with Southern blot analysis of 2 of the cases, was performed and results compared with the findings in the literature.
  
  
  RESULTS
  In the 10 cases studied, the average age of onset of the NHL was 51 years, with a male-to-female ratio of 3:2. Tumefaction was the first clinical sign of disease. Eight of 10 cases were high-grade, large-cell NHLs, centroblastic type. Two cases were high-grade, large-cell NHL, immunoblastic type.
  
  
  CONCLUSIONS
  The immunohistochemical and Southern blot data remain the principal laboratory aids in the diagnosis and characterization of NHL, and they provide critical information for guiding clinicians to the appropriate treatment protocol for these malignancies.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Verona, Faculty of Medicine, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Nocini
authors.forename: L
authors.initials: L
authors.lastname: Lo Muzio
authors.forename: A
authors.initials: A
authors.lastname: Fior
authors.forename: S
authors.initials: S
authors.lastname: Staibano
authors.forename: M D
authors.initials: MD
authors.lastname: Mignogna
mesh_terms: D000328:Adult; D000368:Aged; D015139:Blotting, Southern; D003582:Cytogenetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged