A simple approach to DOTAP and its analogs bearing different fatty acids.
A simple synthesis of N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl sulfate (DOTAP) and its analogs differing in the fatty acids is presented. The synthesis is designed as quasi-one-pot reaction and the precipitating products are purified by simple recrystallization.
Massing
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Department of Medicinal Oncology, Tumor Biology Center, Freiburg, Germany. umas@tumorbio.uni-freiburg.de
Kley
J T
JT
Gürtesch
L
L
Fankhaenel
S
S
D003460:Crystallization; D005227:Fatty Acids / Q000737:chemistry*; D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis* / Q000302:isolation & purification; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000302:isolation & purification; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000302:isolation & purification
D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005456:Fluorescent Dyes; D008055:Lipids; D000644:Quaternary Ammonium Compounds; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane