Heavy metal mutagenicity: insights from bioinorganic model chemistry.
The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered.
Müller
J
J
Fachbereich Chemie, Universität Dortmund, Germany.
Sigel
R K
RK
Lippert
B
B
D020029:Base Pairing; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D006147:Guanine / Q000737:chemistry; D006860:Hydrogen Bonding; D019216:Metals, Heavy / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D009690:Nucleic Acid Conformation
D019216:Metals, Heavy; D009153:Mutagens; D006147:Guanine; D004247:DNA