Effects of branched cyclodextrins on the solubility and stability of terpenes.
In order to investigate the application potential of branched CDs, the solubilizing ability and the stabilizing ability of G2-betaCD and GUG-betaCD were investigated by using twelve terpenes (d-limonene, myrcene, terpinolene, geraniol, l-menthol, nerol, alpha-terpineol, citral, d-citronellal, l-perillaldehyde, (R)-l-carvone, and menthone) as guest compounds. G2-betaCD and GUG-betaCD showed more solubilizing ability for these twelve terpenes than betaCD, and the ability of GUG-betaCD was almost the same as that of G2-betaCD. The stabilizing ability of terpene-GUG-betaCD complexes was different from that of G2-betaCD. GUG-betaCD was superior to G2-betaCD, especially in the solid state. This result may have been caused by the difference in structure of side chain, namely the hydroxymethyl group in G2-betaCD and the carboxyl group in GUG-betaCD.
Ajisaka
N
N
Bio Research Corporation of Yokohama, Japan. bicord@ensuiko.co.jp
Hara
K
K
Mikuni
K
K
Hara
K
K
Hashimoto
H
H
D003505:Cyclodextrins / Q000737:chemistry*; D012995:Solubility; D012996:Solutions; D013729:Terpenes / Q000737:chemistry*; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D012996:Solutions; D013729:Terpenes; D047392:beta-Cyclodextrins; C075170:6-O-maltosyl-beta-cyclodextrin