title: MR imaging differentiation of soft-tissue hemangiomas from malignant soft-tissue masses.
abstract: OBJECTIVE
  The purpose of this study was to determine whether MR imaging features can reliably distinguish hemangiomas from malignant soft-tissue masses.
  
  
  METHODS
  We retrospectively reviewed MR imaging studies of 22 patients with soft-tissue hemangiomas and 22 patients with malignant soft-tissue masses. Images were reviewed and agreement reached by a consensus interpretation of two observers and by an independent observer. Masses were evaluated for signal intensity on T1- and T2-weighted images, for enhancement with gadolinium administration, and for morphology (lobulation, septation, central low-intensity dots). Lesion T2 signal and lesion enhancement with gadolinium administration were also objectively measured using regions of interest and comparison with skeletal muscle.
  
  
  RESULTS
  Signal intensity on T1-weighted imaging of hemangiomas and malignant soft-tissue masses was similar. Subjective analysis showed greater T2 signal and gadolinium enhancement in hemangiomas; however, the differences were not statistically significant on objective analysis. Lobulation, septation, and central low-signal-intensity dots were all more common in hemangiomas, with statistical significance achieved; the combination of all three findings was specific for hemangioma.
  
  
  CONCLUSIONS
  Although no single MR imaging feature was diagnostic in this study, analysis of lesion morphology, signal intensity, and enhancement with gadolinium allowed MR imaging differentiation of hemangiomas from malignant soft-tissue masses.
authors.affiliation: Department of Radiology, C. S. Mott Children's Hospital, University of Michigan Health Centers, Ann Arbor 48109-0252, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Teo
authors.forename: P J
authors.initials: PJ
authors.lastname: Strouse
authors.forename: R J
authors.initials: RJ
authors.lastname: Hernandez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D003937:Diagnosis, Differential; D019786:Gadolinium DTPA; D006391:Hemangioma / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D015588:Observer Variation; D012189:Retrospective Studies; D012983:Soft Tissue Neoplasms / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA