title: A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles.
abstract: [reaction: see text] Interest in bicyclic natural products from the Guttiferae classification has led to the development of an improved method for the selenium-mediated cyclization of alkenyl-substituted beta-dicarbonyls (I) to form a variety of bicyclo[3.3.1]nonan-9-ones (II) both in solution and on solid support.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. kcn@scripps.edu
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: J A
authors.initials: JA
authors.lastname: Pfefferkorn
authors.forename: G Q
authors.initials: GQ
authors.lastname: Cao
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Kessabi
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D003500:Cyclization; D029760:Garcinia / Q000737:chemistry; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D012643:Selenium
chemical_list: D001643:Bridged Bicyclo Compounds; D007202:Indicators and Reagents; D012643:Selenium