title: Human papillomavirus-positive well-differentiated villoglandular adenocarcinoma of the uterine cervix: A case report and review of the literature.
abstract: OBJECTIVE
  A case of well-differentiated villoglandular adenocarcinoma of the uterine cervix, which was positive for human papillomavirus type 18, was reported.
  
  
  METHODS
  The patient was a 52-year-old multipara who was referred to our department because of an abnormal Papanicolaou smear. A 4.0-cm exophytic lesion involving the cervix was detected. She was staged as FIGO IIa and radical hysterectomy combined with bilateral pelvic lymphadenectomy was performed. In addition to histopathological examination of the resected tumor, immunohistochemical studies of estrogen and progesterone receptors were performed using monoclonal antibodies. Detection of human papillomavirus DNA was attempted by polymerase chain reaction using consensus primers.
  
  
  RESULTS
  The tumor was a typical well-differentiated villoglandular adenocarcinoma involving the vaginal wall. Both estrogen and progesterone receptors were negative. Human papillomavirus type 18 DNA was detected in the resected tumor.
  
  
  CONCLUSIONS
  'This is the first report of a case of typical well-differentiated villoglandular adenocarcinoma which was positive for human papillomavirus.
authors.affiliation: Department of Obstetrics and Gynecology, Chiba University School of Medicine, Chiba, 260-8677, Japan. K3126oji@aol.com
authors.forename: K
authors.initials: K
authors.lastname: Yamazawa
authors.forename: H
authors.initials: H
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Seki
authors.forename: A
authors.initials: A
authors.lastname: Mitsuhashi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamata
authors.forename: H
authors.initials: H
authors.lastname: Shirasawa
authors.forename: S
authors.initials: S
authors.lastname: Sekiya
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000235:genetics; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014412:Tumor Virus Infections / Q000150:complications* / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone