title: Synthesis and NMR characterization of a novel class of thienomorphinans.
abstract: [formula: see text] Synthesis of four novel thieno derivatives 4-7 featuring the codeine skeletal backbone is reported. Characterization by 1H and 13C NMR is also discussed, along with binding profile for opioid receptors.
authors.affiliation: SmithKline Beecham S.p.A., Milano, Italy. silvano_ronzoni@sbphrd.com
authors.forename: S
authors.initials: S
authors.lastname: Ronzoni
authors.forename: A
authors.initials: A
authors.lastname: Cerri
authors.forename: G
authors.initials: G
authors.lastname: Dondio
authors.forename: G
authors.initials: G
authors.lastname: Fronza
authors.forename: P
authors.initials: P
authors.lastname: Petrillo
authors.forename: L F
authors.initials: LF
authors.lastname: Raveglia
authors.forename: P A
authors.initials: PA
authors.lastname: Gatti
mesh_terms: D002460:Cell Line; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009019:Morphinans / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010207:Papaver / Q000737:chemistry*; D010946:Plants, Medicinal; D011957:Receptors, Opioid / Q000378:metabolism
chemical_list: D008024:Ligands; D009019:Morphinans; D011957:Receptors, Opioid