title: Sorting and function of peroxisomal membrane proteins.
abstract: Peroxisomes are subcellular organelles and are present in virtually all eukaryotic cells. Characteristic features of these organelles are their inducibility and their functional versatility. Their importance in the intermediary metabolism of cells is exemplified by the discovery of several inborn, fatal peroxisomal errors in man, the so-called peroxisomal disorders. Recent findings in research on peroxisome biogenesis and function have demonstrated that peroxisomal matrix proteins and peroxisomal membrane proteins (PMPs) follow separate pathways to reach their target organelle. This paper addresses the principles of PMP sorting and summarizes the current knowledge of the role of these proteins in organelle biogenesis and function.
authors.affiliation: Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, Postbus 14, 9750 AA, Haren, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Baerends
authors.forename: K N
authors.initials: KN
authors.lastname: Faber
authors.forename: J A
authors.initials: JA
authors.lastname: Kiel
authors.forename: I J
authors.initials: IJ
authors.lastname: van der Klei
authors.forename: W
authors.initials: W
authors.lastname: Harder
authors.forename: M
authors.initials: M
authors.lastname: Veenhuis
mesh_terms: D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D020675:Peroxisomes / Q000378:metabolism*; D011499:Protein Processing, Post-Translational
chemical_list: D008565:Membrane Proteins