Effect of high-dose lidocaine treatment on superoxide dismutase and malon dialdehyde levels in seven diabetic patients.
OBJECTIVE
We report on the use of intravenous (IV) high-dose lidocaine to relieve diabetic neuropathic pain, and the technique's effects on clinical measures of lipid peroxidation.


METHODS
Under continuous electrocardiogram monitoring, IV lidocaine (5 mg kg(-1) in 100 mL saline) was administered over 30 minutes to 7 non-insulin-dependent diabetic patients suffering from neuropathic pain who reported increased pain within the preceding 6 months. This treatment was performed once a week for 1 month. Blood samples were collected from the contralateral limb to determine plasma superoxide dismutase (SOD) and malondialdehyde (MDA) levels on admission and following the final lidocaine administration.


RESULTS
Plasma MDA concentrations significantly decreased after the final IV lidocaine treatment (P < .05, paired t-test), whereas SOD levels did not show a statistically significant difference compared with baseline levels.


CONCLUSIONS
High-dose lidocaine treatment lessens MDA levels, a marker of free-radical-mediated cell damage. This suggests that one of lidocaine's mechanism of action may be its effect on oxygen free radicals, which in turn impacts lipid peroxidation.
Celebi
H
H
Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey.
Bozkirli
F
F
Günaydin
B
B
Bilgihan
A
A
D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000150:complications; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010147:Pain Measurement; D013482:Superoxide Dismutase / Q000378:metabolism*; D013997:Time Factors
D000779:Anesthetics, Local; D008315:Malondialdehyde; D008012:Lidocaine; D013482:Superoxide Dismutase