title: Metal complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid and benzohydroxamic acid. Crystal and molecular structure of [Cu(phen)2(Cl)]Cl x H2Sha, a model for a peroxidase-inhibitor complex.
abstract: Stability constants of iron(III), copper(II), nickel(II) and zinc(II) complexes of salicylhydroxamic acid (H2Sha), anthranilic hydroxamic acid (HAha) and benzohydroxamic acid (HBha) have been determined at 25.0 degrees C, I=0.2 mol dm(-3) KCl in aqueous solution. The complex stability order, iron(III) >> copper(II) > nickel(II) approximately = zinc(II) was observed whilst complexes of H2Sha were found to be more stable than those of the other two ligands. In the preparation of ternary metal ion complexes of these ligands and 1,10-phenanthroline (phen) the crystalline complex [Cu(phen)2(Cl)]Cl x H2Sha was obtained and its crystal structure determined. This complex is a model for hydroxamate-peroxidase inhibitor interactions.
authors.affiliation: Department of Chemistry, Royal College of Surgeons in Ireland, Dublin.
authors.forename: E C
authors.initials: EC
authors.lastname: O'Brien
authors.forename: E
authors.initials: E
authors.lastname: Farkas
authors.forename: M J
authors.initials: MJ
authors.lastname: Gil
authors.forename: D
authors.initials: D
authors.lastname: Fitzgerald
authors.forename: A
authors.initials: A
authors.lastname: Castineras
authors.forename: K B
authors.initials: KB
authors.lastname: Nolan
mesh_terms: D003300:Copper / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000737:chemistry*; D007501:Iron / Q000737:chemistry; D007700:Kinetics; D008670:Metals / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry; D010544:Peroxidases / Q000037:antagonists & inhibitors / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry; D012457:Salicylamides / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry; D062367:ortho-Aminobenzoates / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D008670:Metals; D010618:Phenanthrolines; D012457:Salicylamides; D062367:ortho-Aminobenzoates; C413218:anthranilic hydroxamic acid; D003300:Copper; D009532:Nickel; C005703:salicylhydroxamic acid; D007501:Iron; D010544:Peroxidases; D015032:Zinc; C006696:benzohydroxamic acid; C025205:1,10-phenanthroline