Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity.
Methotrexate, an antirheumatic drug that may increase serum homocysteine, significantly increases mortality in patients with rheumatoid arthritis and cardiovascular comorbidity.
Landewé
R B
RB
van den Borne
B E
BE
Breedveld
F C
FC
Dijkmans
B A
BA
D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000453:epidemiology* / Q000401:mortality; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000453:epidemiology* / Q000401:mortality; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D012189:Retrospective Studies; D016019:Survival Analysis
D018501:Antirheumatic Agents; D008727:Methotrexate