[New data on etiology of heart conduction disturbances].
OBJECTIVE
To make a clinicogenealogical analysis of different types of heart conduction disturbances in families of Krasnoyarsk city.


METHODS
104 probands with ECG-verified idiopathic forms of atrioventricular and intraventricular blocks of different severity and 331 their close relatives (kinship degree I and II) were examined using standard clinical investigations, ECG, echocardioscopy, electrophysical investigations in some cases and coronarography.


RESULTS
All the observed 104 families were divided into 3 groups according to the type of heart conduction in proband. Group 1 consisted of 24 probands with atrioventricular block and 80 their relatives. The sick relatives had for the most part atrioventricular blocks (31.2%). 26 probands of group 2 had complete right bundle branch blocks. Of their 81 relatives, the sick ones had primarily conduction disturbances in right bundle branch (incomplete block--44.7%, a complete block--5.2%). Group 3 consisted of 54 probands with left bundle branch block and 170 relatives. The left bundle branch block was present in 27.4% of the relatives.


CONCLUSIONS
A definite family aggregation of heart conduction disturbances was found. This proves genetic determination of this pathology.
Nikulina
S Iu
SIu
Shul'man
V A
VA
Vorotnikova
Iu V
IuV
Matiushin
G V
GV
D000328:Adult; D000367:Age Factors; D002036:Bundle of His / Q000503:physiopathology*; D002037:Bundle-Branch Block / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D020022:Genetic Predisposition to Disease; D006327:Heart Block / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012800:Siberia / Q000453:epidemiology; D014505:Urban Population