title: Paradoxical increase of tyrosine hydroxylase-immunoreactive retinopetal fibers in the weaver mouse.
abstract: Weaver mice undergo apoptosis of the granule cell precursors of the cerebellum and nonapoptotic death of mesencephalic dopaminergic cells during post-natal development. In contrast, the number of retinal dopaminergic cells was transiently increased in weaver compared to control mice [C. Savy, E. Martin-Martinelli, A. Simon, C. Duyckaerts, C. Verney, C. Adelbrecht, R. Raisman-Vozari, J. Nguyen-Legros, Altered development of dopaminergic cells in the retina of weaver mice, J. Comp. Neurol. 1999;412:656-668]. While re-examining the retinas, we observed, in the nerve fiber layer, retinopetal tyrosine hydroxylase-immunoreactive fibers, which were dramatically increased in number throughout development and adulthood in the weaver compared to control mice.
authors.affiliation: Laboratoire de Neurocytologie Oculaire, INSERM U86, 15 rue de l'Ecole de Médecine, 75270 Cedex 06, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: C
authors.initials: C
authors.lastname: Savy
authors.forename: E
authors.initials: E
authors.lastname: Martin-Martinelli
authors.forename: A
authors.initials: A
authors.lastname: Douhou
authors.forename: F
authors.initials: F
authors.lastname: Frédéric
authors.forename: C
authors.initials: C
authors.lastname: Verney
authors.forename: J
authors.initials: J
authors.lastname: Nguyen-Legros
authors.forename: R
authors.initials: R
authors.lastname: Raisman-Vozari
mesh_terms: D000818:Animals; D000906:Antibodies; D017209:Apoptosis / Q000502:physiology*; D004195:Disease Models, Animal; D005838:Genotype; D051379:Mice; D008818:Mice, Neurologic Mutants; D008854:Microscopy, Electron; D009412:Nerve Fibers / Q000201:enzymology / Q000648:ultrastructure; D010300:Parkinson Disease / Q000201:enzymology / Q000235:genetics; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000201:enzymology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis* / Q000276:immunology
chemical_list: D000906:Antibodies; D014446:Tyrosine 3-Monooxygenase