Myeloblastic leukemia with massive neoplastic infiltration of the skin and mediastinum in a cow.
An acute myeloblastic leukemia was found in a 3.5-year-old Holstein cow. The neoplasm was characterized by massive tumor growths, and there were multiple tumor nodules in the dermis or subcutis and a large tumor mass in the mediastinum. This tumor showed negative reactivity for CD3, CD79a, major histocompatibility complex class II and myeloid/histiocyte antigen. Ultrastructural features such as dispersed cytoplasmic granules and poorly developed organelles were compatible with those of early promyelocytes.
Takahashi
T
T
Tochigi Prefectural Animal Hygiene Laboratory, Hiraide Kogyo-Danchi, Utsunomiya, Japan.
Hagiwara
A
A
Ezura
K
K
Shibahara
T
T
Kadota
K
K
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000662:veterinary*; D008479:Mediastinal Neoplasms / Q000556:secondary / Q000662:veterinary*; D008482:Mediastinum / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000556:secondary / Q000662:veterinary*