A method for constructing the C44-C51 side chain of altohyrtin C.
[formula: see text] A method to construct the C44-C51 side chain of altohyrtin C has been developed and applied to a model aldehyde derived from D-glucose. The approach relies on a Wittig reaction to couple the side chain to an aldehyde and utilizes an allylic diazene rearrangement to place the C45 double bond in the correct position.
Ott
G R
GR
Department of Chemistry, University of California, Berkeley 94720, USA.
Heathcock
C H
CH
D000447:Aldehydes / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry*; D015394:Molecular Structure; D000095702:Polyether Toxins
D000447:Aldehydes; D005947:Glucose; D006571:Heterocyclic Compounds; D018942:Macrolides; C409088:altohyrtin C; D000095702:Polyether Toxins