title: Circadian rhythms in healthy aging--effects downstream from the pacemaker.
abstract: Using both previously published findings and entirely new data, we present evidence in support of the argument that the circadian dysfunction of advancing age in the healthy human is primarily one of failing to transduce the circadian signal from the circadian timing system (CTS) to rhythms "downstream" from the pacemaker rather than one of failing to generate the circadian signal itself. Two downstream rhythms are considered: subjective alertness and objective performance. For subjective alertness, we show that in both normal nychthemeral (24 h routine, sleeping at night) and unmasking (36 h of constant wakeful bed rest) conditions, advancing age, especially in men, leads to flattening of subjective alertness rhythms, even when circadian temperature rhythms are relatively robust. For objective performance, an unmasking experiment involving manual dexterity, visual search, and visual vigilance tasks was used to demonstrate that the relationship between temperature and performance is strong in the young, but not in older subjects (and especially not in older men).
authors.affiliation: Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA. monkth@msx.upmc.edu
authors.forename: T H
authors.initials: TH
authors.lastname: Monk
authors.forename: D J
authors.initials: DJ
authors.lastname: Kupfer
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001143:Arousal / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011597:Psychomotor Performance / Q000502:physiology; D015398:Signal Transduction