title: Oxidative injury is present in Purkinje cells in patients with olivopontocerebellar atrophy.
abstract: To verify the presence of lipid peroxidation products in spinocerebellar degeneration (SCD), the cerebella from eight patients with olivopontocerebellar atrophy (OPCA) and six non-OPCA patients were immunohistochemically investigated with 4-hydroxy-2-nonenal (HNE) antibody. On average, 84.6% of Purkinje cells were positively or strongly positively immunostained in OPCA patients while only 15.5% were positive in non-OPCA patients. Other cells in the molecular and granular layers showed no obvious immunoreactivity. These data suggest that a lipid peroxidation product is present in Purkinje cells of OPCA patients and that oxidative stress may play an important role in the degeneration process of SCD.
authors.affiliation: Department of Neurology, Kumamoto University School of Medicine, 1-1-1 Honjo, 860-0811, Kumamoto, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: K
authors.initials: K
authors.lastname: Obayashi
authors.forename: H
authors.initials: H
authors.lastname: Terazaki
authors.forename: N
authors.initials: N
authors.lastname: Sakashita
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: E
authors.initials: E
authors.lastname: Ohama
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Uchino
mesh_terms: D000368:Aged; D000447:Aldehydes / Q000276:immunology / Q000378:metabolism; D000906:Antibodies; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009849:Olivopontocerebellar Atrophies / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress; D011689:Purkinje Cells / Q000378:metabolism*
chemical_list: D000447:Aldehydes; D000906:Antibodies; C027576:4-hydroxy-2-nonenal