title: Inhibition of protein phosphatases by Michael adducts of ascorbic acid analogues with alpha,beta-unsaturated carbonyl compounds.
abstract: By investigating the stereospecific Michael reaction of derivatives of ascorbic acid with acrolein we obtained a novel class of protein Ser/Thr phosphatase inhibitors. The inhibitory effect of the Michael adducts was examined using the canonical protein phosphatases type 1, 2A and 2B. Of the isozymes examined the type 1 isoform was strongly inhibited.
authors.affiliation: Institut für Pharmazie, Universität Leipzig, Germany.
authors.forename: U G
authors.initials: UG
authors.lastname: Witt
authors.forename: J E
authors.initials: JE
authors.lastname: Schultz
authors.forename: M
authors.initials: M
authors.lastname: Dölker
authors.forename: K
authors.initials: K
authors.lastname: Eger
mesh_terms: D000171:Acrolein / Q000737:chemistry*; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors*; D013057:Spectrum Analysis
chemical_list: D000171:Acrolein; D010749:Phosphoprotein Phosphatases; D001205:Ascorbic Acid