title: Enteric viral infections in pre-school children in Karachi, Pakistan.
abstract: A prospective study was conducted in Karachi, Pakistan on the virology of enteropathogens excreted by children with acute gastroenteritis and the results were compared with a control group of healthy children. Rotavirus and Adenovirus detection was done using ELISA techniques, while enterovirus isolation was done by virus culture. In 1990, 12.3% children with acute watery diarrhoea excreted rotavirus, as compared to 24.4% children in 1991. None of the healthy children excreted adenovirus 40 and 41. Preliminary results of 1992 revealed that rotavirus was seen in 13% of children with acute watery diarrhoea and adenovirus in 10% of children. Enteroviruses were isolated in the same frequency in all three groups i.e. children with acute watery diarrhoea, children with poliomyelitis and healthy children. Non-polio enteroviruses were excreted in 50-52% in all the 3 groups. The rate of enterovirus excretion is much higher than seen in other developed countries and is the same in children with diarrhoea and healthy children.
authors.affiliation: Department of Pediatrics, Civil Hospital, Karachi, Pakistan.
authors.forename: M
authors.initials: M
authors.lastname: Agboatwalla
authors.forename: S
authors.initials: S
authors.lastname: Isomura
authors.forename: D S
authors.initials: DS
authors.lastname: Akram
authors.forename: Y
authors.initials: Y
authors.lastname: Isihara
authors.forename: K
authors.initials: K
authors.lastname: Sakae
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: O
authors.initials: O
authors.lastname: Nishuo
mesh_terms: D000208:Acute Disease; D000258:Adenovirus Infections, Human / Q000453:epidemiology*; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology* / Q000821:virology*; D004769:Enterovirus Infections / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010154:Pakistan / Q000453:epidemiology; D011051:Poliomyelitis / Q000821:virology; D011446:Prospective Studies; D012400:Rotavirus Infections / Q000453:epidemiology*