Lewis acid-mediated displacements of alkoxydioxolanes: synthesis of a 1,2-dioxolane natural product.
[formula: see text] Addition of electron-rich alkenes to the peroxycarbenium ions derived from Lewis acid-mediated ionization of 3-alkoxy-1,2-dioxolanes provides an efficient route for the synthesis of substituted 1,2-dioxolanes. The methodology is illustrated with a rapid synthesis of a 1,2-dioxolane natural product related to the plakinic acids.
Dussault
P H
PH
Department of Chemistry, University of Nebraska-Lincoln 68588-0304, USA. pdussault1@unl.edu
Liu
X
X
D000143:Acids / Q000737:chemistry*; D004148:Dioxolanes / Q000737:chemistry*
D000143:Acids; D004148:Dioxolanes