Utility of early testing for HCV viremia as predictive factor of sustained response during interferon or interferon plus ribavirin treatment.
OBJECTIVE
To evaluate the utility of early testing for hepatitis C viremia as a predictor of treatment outcome during interferon or combination therapy.


METHODS
We studied 184 patients with chronic hepatitis C who received interferon and were monitored for HCV RNA. Sixty-two patients received interferon alone for 12 months and 122 patients, who were still HCV RNA positive at 2 months, received an additional 12-month course of interferon and ribavirin combination therapy.


RESULTS
Using this strategy, sustained response occurred in a total of 34 patients (18.5%). Independent variables associated with sustained response were HCV genotype (p=0.06), viral load < or = 5.1 logs/ml (p= 0.005) and negative HCV RNA at 1 month (p<0.0001) in the interferon group, and female sex (p=0.04), genotype (p=0.03), viral load < or = 5.5 logs/ml (p=0.01), normal ALT (p=0.001) and decline in viral load > or = 1.2 logs/ml after 2 months of interferon monotherapy (p<0.001) and negative viremia at 5 months of ribavirin onset (p<0.0001) in the combination therapy group. Persistence of viremia at 1 month of interferon monotherapy and at 5 months of combination therapy were the strongest predictors of non-response (negative predictive value of 100% and 99%, respectively).


CONCLUSIONS
Qualitative assessment of HCV RNA during treatment is the strongest predictor of sustained response during interferon or combination therapy for chronic hepatitis C.
Castro
F J
FJ
Department of Medicine, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Esteban
J I
JI
Sauleda
S
S
Viladomiu
L
L
Dragon
E A
EA
Esteban
R
R
Guardia
J
J
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D016903:Drug Monitoring; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000188:drug therapy* / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome; D014766:Viremia
D000998:Antiviral Agents; D012254:Ribavirin; D007372:Interferons