Coumarins and carbazoles with antiplasmodial activity from Clausena harmandiana.
Activity guided fractionation of extracts from Clausena harmandiana have led to the identification of four known compounds, heptaphylline (1), clausine K (2), dentatin (5), and clausarin (6). All these compounds, except clausine K (2), exhibited antiplasmodial activity against Plasmodium falciparum. While the new dimethylated derivative 4, derived from 2, showed no antiplasmodial activity, the monomethylated product 3 (clausine H) exhibited activity comparable to that observed for compounds 1 and 5.
Yenjai
C
C
Sripontan
S
S
Sriprajun
P
P
Kittakoop
P
P
Jintasirikul
A
A
Tanticharoen
M
M
Thebtaranonth
Y
Y
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D010944:Plants / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*
D000962:Antimalarials; D002227:Carbazoles; D003374:Coumarins