A general route to 4-imidazolyl-containing multidentate ligands for biomimetic studies.
[formula: see text] 4-iodo-1-tritylimidazole undergoes magnesium-iodine exchange with a Grignard reagent to give selectively the 4-magnesioimidazole derivative, which reacts with esters to form a variety of poly-4-imidazolyl carbinol compounds in 40-79% yields. A wide range of bi-, tri-, and pentadentate ligands featuring 4-substituted imidazole units have been efficiently synthesized.
Collman
J P
JP
Department of Chemistry, Stanford University, California 94305-5080, USA. jpc@chem.stanford.edu
Zhong
M
M
Wang
Z
Z
D007093:Imidazoles / Q000737:chemistry*; D008024:Ligands; D018716:Molecular Mimicry
D007093:Imidazoles; D008024:Ligands