Microbiological transformation of enrofloxacin by the fungus Mucor ramannianus.
Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N-oxide (62% of the total absorbance), N-acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).
Parshikov
I A
IA
Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.
Freeman
J P
JP
Lay
J O
JO
Beger
R D
RD
Williams
A J
AJ
Sutherland
J B
JB
D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D009682:Magnetic Resonance Spectroscopy; D009089:Mucor / Q000254:growth & development / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry / Q000378:metabolism*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin