title: Myocardial scintigraphy using iodine-123 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid predicts the response to beta-blocker therapy in patients with dilated cardiomyopathy but does not reflect therapeutic effect.
abstract: Myocardial fatty acid metabolism is disturbed in patients with idiopathic dilated cardiomyopathy. Myocardial scintigraphy using iodine-123 15-(p-iodophenyl)-3-R, S-methylpentadecanoic acid(BMIPP) was used to assess the response to beta-blocker therapy in 19 patients with dilated cardiomyopathy. BMIPP myocardial scintigraphy was performed before and 6 months after initiating beta-blocker therapy with metoprolol. Cardiac BMIPP uptake was assessed as the total defect score (TDS) and heart-to-mediastinum activity (H/M) ratio. Patients were classified retrospectively as responders with an improvement of at least one functional class (New York Heart Association) or an increase in ejection fraction of > or = 0.10 at 6 months, or as nonresponders meeting neither criterion. Responders had a significantly better pretreatment TDS (p < 0.005) and H/M ratio (p < 0.0001) than nonresponders. TDS exhibited no significant changes over 6 months in either group (responders: 13.2 +/- 3.7 vs 12.5 +/- 3.3; nonresponders: 20.8 +/- 6.5 vs 20.5 +/- 3.0). Responders showed no significant changes in H/M ratio (2.47 +/- 0.28 vs 2.43 +/- 0.42); paradoxically, nonresponders showed a significant increase from 1.82 +/- 0.11 to 2.10 +/- 0.19 (p < 0.05), suggesting that beta-blocker therapy protected the myocardial fatty acid metabolism even in the absence of clinical improvement. BMIPP myocardial scintigraphy provides a prediction of response to beta-blocker treatment, but does not reflect the therapeutic effect in responders at 6 months.
authors.affiliation: Department of Cardiology, Kagoshima City Medical Association Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: M
authors.initials: M
authors.lastname: Tahara
authors.forename: H
authors.initials: H
authors.lastname: Torii
authors.forename: M
authors.initials: M
authors.lastname: Akimoto
authors.forename: K
authors.initials: K
authors.lastname: Kihara
authors.forename: C
authors.initials: C
authors.lastname: Tei
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D004452:Echocardiography; D005227:Fatty Acids; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use; D008875:Middle Aged; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D013318:Stroke Volume
chemical_list: D000319:Adrenergic beta-Antagonists; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid; D008790:Metoprolol