RNA bound to a solid phase can select an amino acid and facilitate subsequent amide bond formation.
Polyadenylic acid (Poly A) immobilised on silica gel stereoselectively binds L-lysine from dilute aqueous solution. When the resulting complex is suspended in an organic solvent and liquid ammonia added, lysinamide is formed.
Mellersh
A
A
Chemistry Department, University of Derby, UK.
Wilkinson
A S
AS
D000577:Amides / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D000641:Ammonia; D008239:Lysine / Q000378:metabolism; D011061:Poly A / Q000378:metabolism; D012313:RNA / Q000378:metabolism*; D058428:Silica Gel; D012822:Silicon Dioxide; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013237:Stereoisomerism
D000577:Amides; D000596:Amino Acids; D012997:Solvents; D011061:Poly A; D058428:Silica Gel; D012313:RNA; D012822:Silicon Dioxide; D000641:Ammonia; D008239:Lysine