title: Development of controlled release formulations of alachlor in ethylcellulose.
abstract: The herbicide alachlor (2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)-acetamide) is frequently implicated in groundwater contamination. Microencapsulated alachlor should have reduced potential for leaching in the soil while maintaining effective biological activity. Microspheres of alachlor were prepared using ethylcellulose, according to the solvent evaporation method. The influence of formulation variables affecting the release rate of pesticide, such as the molecular weight of ethylcellulose, the amount of emulsifying agent, the pesticide/polymer ratio and the particle size, were investigated. The results showed that microspheres retarded the release of alachlor in different degrees. Pesticide/polymer ratio and particle size were the more important factors determining the alachlor release. Ethylcellulose microspheres may prove useful for the prolonged release of alachlor.
authors.affiliation: Instituto de Recursos Naturales y Agrobiologia, Sevilla, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Fernandez-Urrusuno
authors.forename: J M
authors.initials: JM
authors.lastname: Gines
authors.forename: E
authors.initials: E
authors.lastname: Morillo
mesh_terms: D015502:Absorptiometry, Photon; D000081:Acetamides / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004655:Emulsions; D006540:Herbicides / Q000737:chemistry*; D008970:Molecular Weight; D010968:Plasticizers; D013501:Surface-Active Agents
chemical_list: D000081:Acetamides; D003692:Delayed-Action Preparations; D004655:Emulsions; D006540:Herbicides; D010968:Plasticizers; D013501:Surface-Active Agents; C000188:alachlor; C013517:ethyl cellulose; D002482:Cellulose