title: Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in men undergoing coronary angiography.
abstract: This study was carried out in order to investigate the relationship between endogenous sex steroid hormones and coronary artery disease (CAD). Three hundred and thirty-seven men undergoing coronary angiography were enrolled in the study. Total testosterone, estradiol, free testosterone levels in men with CAD (n = 213) were compared to those of men without CAD (n = 124). No significant differences were found in the serum concentrations of estradiol, total and free testosterone and serum lipid profile between the two groups. Total and free testosterone were negatively (p < 0.05 to p < 0.001) and estradiol was positively (p < 0.05) correlated with age in both groups. Total cholesterol and low-density-lipoprotein levels were positively correlated with the level of free testosterone (r = 0.221, p < 0.01; r = 0.173, p < 0.05, respectively), and high-density-lipoprotein levels were negatively correlated with total testosterone in patients with CAD (r = -0.166, p < 0.05). The results of this study do not support the role of sex steroid hormones in CAD. However, the relationship between sex steroids and serum lipids needs further clarification.
authors.affiliation: Hacettepe University, Department of Cardiology, Ankara, Turkey. ayliny@ato.org.tr
authors.forename: G
authors.initials: G
authors.lastname: Kabakci
authors.forename: A
authors.initials: A
authors.lastname: Yildirir
authors.forename: I
authors.initials: I
authors.lastname: Can
authors.forename: I
authors.initials: I
authors.lastname: Unsal
authors.forename: B
authors.initials: B
authors.lastname: Erbas
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging* / Q000453:epidemiology; D004958:Estradiol / Q000032:analysis / Q000097:blood*; D006801:Humans; D015994:Incidence; D008074:Lipoproteins / Q000032:analysis / Q000097:blood*; D008075:Lipoproteins, HDL / Q000032:analysis / Q000097:blood; D008077:Lipoproteins, LDL / Q000032:analysis / Q000097:blood; D008297:Male; D008875:Middle Aged; D011336:Probability; D011863:Radioimmunoassay; D012016:Reference Values; D012307:Risk Factors; D013739:Testosterone / Q000032:analysis / Q000097:blood*; D014280:Triglycerides / Q000032:analysis / Q000097:blood*
chemical_list: D015415:Biomarkers; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D013739:Testosterone; D004958:Estradiol