[Effect of recombinant interleukin-1 beta on microbial flora of the middle ear in patients with chronic purulent otitis media].
Betaleukin was given to 60 patients with various forms of otitis media purulenta chronica (OMPC). Symptoms of the purulent exacerbation were relieved in 43.3% of the patients, the clinical course improved in 18.3%. No response was achieved in 40% of the treated patients. Betaleukin proved highly effective in management of exacerbations of uncomplicated OMPC though it has no direct antimicrobial activity.
Riazantsev
S V
SV
Chernushevich
I I
II
D002908:Chronic Disease; D004432:Ear, Middle / Q000187:drug effects*; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007370:Interferon Type I / Q000494:pharmacology* / Q000627:therapeutic use; D007710:Klebsiella Infections; D010035:Otitis Media, Suppurative / Q000188:drug therapy / Q000382:microbiology*; D011552:Pseudomonas Infections; D011994:Recombinant Proteins; D013203:Staphylococcal Infections
D007155:Immunologic Factors; D007370:Interferon Type I; D011994:Recombinant Proteins