Penetration of neurotrophins and cytokines across the blood-brain/blood-spinal cord barrier.
Now that peptides are no longer considered too large to cross the blood-brain barrier, attention has turned to the possibility that larger substances like polypeptides might also enter the central nervous system (CNS). This review summarizes evidence showing that many cytokines and neurotrophins not only enter the brain but also enter the spinal cord, sometimes faster than into the brain.
Pan
W
VA Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA 70146, USA
Kastin
AJ