title: [Treatment of perianal Crohn's disease].
abstract: Perianal Crohn's disease (PACD) is defined as the presence of persistent lesions in the anal canal and perianal region in patients with Crohn's disease. The relative incidence of PACD in Crohn's disease patients ranges from 15 to 80% in the literature, depending on the accuracy of the clinical investigations and the clinical importance attributed to the lesions in the various study populations. The incidence is significantly higher if the intestinal disease is located in the colon-rectum rather than in the small bowel. We reviewed our experience in 105 patients with PACD, 32 of whom presenting rectal localisation of the primary disease. We observed 2 stenoses, 3 perirectal abscesses, 3 rectal ulcerations, 5 skin tags, 10 fissures and 77 fistulas. Two dilatations under narcosis, 2 intrarectal drainages of abscesses, 19 fistulotomies, 7 partial fistulotomies and insertion of loose setons, 47 loose setons and 4 anoperineal diversions were performed. The remaining patients received medical and topical treatments. After a median follow-up of 30 months, 90 patients (86%) showed a good response with improvement in functional scores, while 15 (14%) showed no improvement or a worsening requiring proctectomy in 13 cases. All patients submitted to proctectomy had rectal localization of the disease.
authors.affiliation: Dipartimento di Scienze Chirurgiche Struttura Complessa di Chirurgia Generale Flajani Ospedale San Camillo De Lellis, Azienda Ospedaliera San Camillo-Forlanini, Roma.
authors.forename: R
authors.initials: R
authors.lastname: Tersigni
authors.forename: L
authors.initials: L
authors.lastname: Alessandroni
authors.forename: A
authors.initials: A
authors.lastname: Kohn
authors.forename: G
authors.initials: G
authors.lastname: Speziale
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001004:Anus Diseases / Q000473:pathology / Q000601:surgery; D003082:Colectomy; D003092:Colitis / Q000473:pathology / Q000601:surgery; D003125:Colostomy; D003424:Crohn Disease / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007079:Ileitis / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012003:Rectal Fistula / Q000209:etiology / Q000473:pathology / Q000601:surgery; D012006:Rectovaginal Fistula / Q000601:surgery; D012007:Rectum / Q000473:pathology / Q000601:surgery; D013997:Time Factors