title: Water extract of defatted rice bran suppresses visceral fat accumulation in rats.
abstract: Rice bran has been reported to inhibit pancreatic lipase activity in vitro. This action shows that administration of rice bran may result in a decrease in plasma triglyceride levels and suppress accumulation of fat in vivo. We administered water extract of defatted rice bran (WED-rice bran) to rats to determine its effects. Single administration of WED-rice bran at a dose of 1 g/kg body weight caused a decrease in plasma triglyceride levels in fat emulsion induced hypertriglyceridemic rats. Four week administration of WED-rice bran suppressed accumulation of visceral fat and body weight gain without influencing food consumption, liver function, and renal function. These results indicate that a reduction of plasma triglycerides and suppression of visceral fat accumulation may be induced by pancreatic lipase inhibition caused by administration of WED-rice bran.
authors.affiliation: Nutrition Research Institute and Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc., Muya-cho, Naruto, Tokushima 772-8601, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tsutsumi
authors.forename: Y
authors.initials: Y
authors.lastname: Kawauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kondo
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: O
authors.initials: O
authors.lastname: Koshitani
authors.forename: H
authors.initials: H
authors.lastname: Kohri
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001835:Body Weight; D008049:Lipase / Q000037:antagonists & inhibitors; D008055:Lipids / Q000097:blood; D008297:Male; D009929:Organ Size; D012275:Oryza / Q000737:chemistry*; D010179:Pancreas / Q000201:enzymology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000737:chemistry*
chemical_list: D008055:Lipids; D010936:Plant Extracts; D014867:Water; D008049:Lipase