title: Heavy metal mutagenicity: insights from bioinorganic model chemistry.
abstract: The mutagenicity of metal species may be the result of a direct interaction with the target molecule DNA. Possible scenarios leading to nucleobase mispairing are discussed, and selected examples are presented. They include changes in nucleobase selectivity as a consequence of alterations in acid-base properties of nucleobase atoms and groups involved in complementary H bond formation, guanine deprotonation, and stabilization of rare nucleobase tautomers by metal ions. Oxidative nucleobase damage brought about by metal species will not be considered.
authors.affiliation: Fachbereich Chemie, Universität Dortmund, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: R K
authors.initials: RK
authors.lastname: Sigel
authors.forename: B
authors.initials: B
authors.lastname: Lippert
mesh_terms: D020029:Base Pairing; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D006147:Guanine / Q000737:chemistry; D006860:Hydrogen Bonding; D019216:Metals, Heavy / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D009690:Nucleic Acid Conformation
chemical_list: D019216:Metals, Heavy; D009153:Mutagens; D006147:Guanine; D004247:DNA