title: [Current status of immunity to hepatitis A virus in various adult groups].
abstract: BACKGROUND
  As sanitary and economic conditions improve, the prevalence of antibodies to hepatitis A is now significantly lower.
  
  
  OBJECTIVE
  To evaluate the prevalence of hepatitis A virus antibodies in healthy Chilean adults.
  
  
  METHODS
  Antibodies to hepatitis A virus were measured, using a commercial ELISA assay, in 215 voluntary blood donors (163 male, aged 19 to 30 years old) and 295 medical students and health personnel (156 male, aged 19 to 39 years old), residing in Valdivia, Chile.
  
  
  RESULTS
  Antibodies against hepatitis A virus were found in 68.2% of the total sample (351/510). Ninety percent of flood donors and 54% of health personnel and students were positive (p < 0.01). Age specific prevalence in blood donors 19 to 22, 23 to 29 and 27 to 30 years old was 81.0%, 95.2% and 95.6% respectively. Among the same age groups in medical students, the prevalence was 47.9%, 53.2% and 61.9% respectively (p < 0.01).
  
  
  CONCLUSIONS
  This study indicates a reduction in the prevalence of hepatitis A virus antibodies among adults in Valdivia (Chile). Differences detected between individuals are probably related to different socioeconomic levels. Medical students have an increased risk for hepatitis A infections than the general population.
authors.affiliation: Departamento Microbiología, Facultad Medicina Oriente, Universidad de Chile. hibarra@uach.cl
authors.forename: H
authors.initials: H
authors.lastname: Ibarra
authors.forename: S
authors.initials: S
authors.lastname: Riedemann
authors.forename: V
authors.initials: V
authors.lastname: Prado
authors.forename: G
authors.initials: G
authors.lastname: Reinhardt
authors.forename: I
authors.initials: I
authors.lastname: Vega
authors.forename: M
authors.initials: M
authors.lastname: Potin
authors.forename: P
authors.initials: P
authors.lastname: Frick
mesh_terms: D000328:Adult; D000367:Age Factors; D002677:Chile; D005260:Female; D006506:Hepatitis A / Q000097:blood / Q000276:immunology*; D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies / Q000097:blood*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D008297:Male; D015995:Prevalence
chemical_list: D035922:Hepatitis A Antibodies; D006508:Hepatitis Antibodies