[An analysis of 3H-tamoxifen binding with the cell plasma membranes of the rat uterus].
The effect of phencarol, ranitidine, propranolol, atropine, and diethylstilbestrol (known as modulators of the tamoxifen-binding sites in plasma membranes) on the 3H-tamoxifen binding to the plasma membrane fraction of white rat uterine cells was studied by determining the amounts of estradiol and H1- and H2-receptors. The interaction of tamoxifen with various receptors of uterine cells may be significant for evaluation of the tumor activity of this compound.
Kareva
E N
EN
Molecular Pharmacology and Radiobiology Chair, State Medical University, Moscow, Russia.
Solov'eva
E V
EV
Kirpichnikova
N V
NV
Tumanov
A V
AV
Rybalko
N Iu
NIu
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000493:pharmacokinetics*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D008024:Ligands; D051381:Rats; D011959:Receptors, Estradiol / Q000187:drug effects / Q000378:metabolism; D018709:Statistics, Nonparametric; D013629:Tamoxifen / Q000493:pharmacokinetics*; D014316:Tritium; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D018931:Antineoplastic Agents, Hormonal; D008024:Ligands; D011959:Receptors, Estradiol; D013629:Tamoxifen; D014316:Tritium