title: Asymmetric solid-phase synthesis of (3'R,4'R)-di-O-cis-acyl 3-carboxyl khellactones.
abstract: [formula: see text] We describe a practical parallel synthesis of (3'R,4'R)-di-O-cis-acyl 3-carboxyl khellactones on a solid phase in high yield. The highlights of this synthesis include a Knoevenagel condensation, asymmetric dihydroxylation, catalyzed acylation, and product cleavage from the solid support.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Xia
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Brossi
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000215:Acylation; D003374:Coumarins / Q000138:chemical synthesis*; D006900:Hydroxylation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry
chemical_list: D003374:Coumarins