Application of ligand-exchange capillary electrophoresis to the chiral separation of alpha-hydroxy acids and beta-blockers.
The application of the principle of ligand-exchange capillary electrophoresis to two substance classes is described. As chiral selector N-(2-hydroxyoctyl)-L-4-hydroxyproline-copper(II) complex was used. This principle was applied to the chiral separation of alpha-hydroxy acids and drugs containing amino alcohol structure such as beta-blockers. The enantioselectivity was found to be strongly dependent on pH corresponding to the optimal conditions for complex formation for each structure class.
Schmid
M G
MG
Institute of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria.
Lecnik
O
O
Sitte
U
U
Gübitz
G
G
D000319:Adrenergic beta-Antagonists / Q000302:isolation & purification*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006880:Hydroxy Acids / Q000302:isolation & purification*; D008024:Ligands; D013237:Stereoisomerism
D000319:Adrenergic beta-Antagonists; D006880:Hydroxy Acids; D008024:Ligands