title: Fluconazole.
abstract: Incidence of systemic candidiasis is increasing with improvement in the survival of high risk neonates who undergo multiple interventions. Therapies available to treat systemic fungal infection are few and have several drawbacks. Fluconazole, a new triazole derivative may be a useful anti-fungal agent in view of its excellent oral absorption, easy administration, low plasma protein affinity, long half-life, high concentrations in urine and CSF, minimal adverse reactions, wide spectrum of anti-fungal activity and high specificity for fungal cytochrome P450 system. Its utility in neonates and children with candidiasis has already been documented by few case reports and studies.
authors.affiliation: Department of Pediatrics, Post Graduate Institute for Medical Education and Research, Chandigarh.
authors.forename: P B
authors.initials: PB
authors.lastname: Agrawal
authors.forename: A
authors.initials: A
authors.lastname: Narang
authors.forename: P
authors.initials: P
authors.lastname: Kumar
mesh_terms: D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D015725:Fluconazole / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole