Activation of human leukocytes by acute hypoxia.
Exposure of human leukocytes to 12% and 6% O(2) in vitro resulted in striking ultrastructural and morphological changes. These changes included the appearance of crater-like holes, a reduction in granular size and disruption of the cellular membrane. The implications of these findings is discussed.
Sanidas
D
D
Department of Biomedical Sciences, School of Natural & Environmental Sciences, Coventry University, Cox Street Coventry, CV1 5FB, Birmingham, UK.
Garnham
A
A
Mian
R
R
D000328:Adult; D015687:Cell Hypoxia / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000502:physiology* / Q000648:ultrastructure; D008262:Macrophage Activation / Q000502:physiology*; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D013347:Subcellular Fractions / Q000502:physiology / Q000648:ultrastructure