Synthesis of modified oligodeoxyribonucleotides on a solid-phase support via derivatization of a selectively revealed 2'-amino-2'-deoxyuridine.
[formula: see text] High yields of oligodeoxyribonucleotides modified at the C2'-position of site specifically incorporated 2'-amino-2'-deoxyuridine are obtained by photolytically unmasking the nucleophile in an otherwise protected solid-phase support-bound biopolymer.
Hwang
J T
JT
Department of Chemistry, Colorado State University, Fort Collins 80523, USA.
Greenberg
M M
MM
D002851:Chromatography, High Pressure Liquid; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013058:Mass Spectrometry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D010782:Photolysis
C410434:2'-amino-2'-deoxyuridine; D009838:Oligodeoxyribonucleotides; D003857:Deoxyuridine