title: Oral soft tissue manifestations in HIV-positive vs. HIV-negative children from an inner city population: a two-year observational study.
abstract: OBJECTIVE
  Data accrued after two years of longitudinal observation of oral soft tissue lesions in a cohort of HIV-infected children and comparisons to a group of uninfected controls is presented.
  
  
  METHODS
  One hundred and four HIV-positive subjects were enrolled from an inner city pediatric HIV clinic and HIV-negative household peers served as control. Oral exams were performed at six-month intervals while laboratory data of interest were obtained from the children's medical records.
  
  
  RESULTS
  HIV-positive children had significantly more oral soft tissue lesions than their HIV-negative peers. In particular, the prevalence of candidiasis, linear gingival erythema and median rhomboid glossitis were high. However, oral lesions were not good predictors of mortality and only candidiasis was associated with a low CD4 count.
  
  
  CONCLUSIONS
  Oral soft tissue lesions were common among HIV-positive children. While candidiasis was correlated with advanced disease, oral lesions were not good predictors of mortality.
authors.affiliation: University of Connecticut School of Dental Medicine, Farmington, USA. barasaff@cs.com
authors.forename: A
authors.initials: A
authors.lastname: Barasch
authors.forename: M M
authors.initials: MM
authors.lastname: Safford
authors.forename: F A
authors.initials: FA
authors.lastname: Catalanotto
authors.forename: D H
authors.initials: DH
authors.lastname: Fine
authors.forename: R V
authors.initials: RV
authors.lastname: Katz
mesh_terms: D000293:Adolescent; D018791:CD4 Lymphocyte Count; D002180:Candidiasis, Oral / Q000209:etiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004890:Erythema / Q000209:etiology; D005006:Ethnicity; D005260:Female; D005891:Gingivitis / Q000209:etiology; D005928:Glossitis / Q000209:etiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D009059:Mouth Diseases / Q000209:etiology*; D016017:Odds Ratio; D010379:Peer Group; D011204:Poverty Areas; D011379:Prognosis