title: Single blind, randomised trial of efficacy and acceptability of oral picolax versus self administered phosphate enema in bowel preparation for flexible sigmoidoscopy screening.
abstract: OBJECTIVE
  To compare the acceptability and efficacy of two methods of self administered bowel preparation for flexible sigmoidoscopy screening: a single phosphate enema and a single sachet of Picolax.
  
  
  METHODS
  Single blind, randomised trial.
  
  
  METHODS
  Endoscopy units of two general hospitals.
  
  
  METHODS
  1442 men and women aged 55-64 years who had agreed to be screened by flexible sigmoidoscopy. MAIN OUTCOME MESURESs: Attendance rates, compliance with allocated preparations, adverse effects, quality of bowel preparation, procedure time, and yield of neoplasia.
  
  
  RESULTS
  Compliance with the enema was higher than with the Picolax (608 (84%) v 566 (79%); difference 6%, 95% confidence interval 2% to 10%). Almost half of those who refused Picolax used an enema at home. Wind, incontinence, and sleep disturbance were more frequent in the Picolax group than the enema group; bottom soreness was more frequent in the enema group. Around 30% (187) found the diet restriction required by Picolax difficult; 78% (471) found the enema easy to administer. The quality of preparation was better with the enema; the proportion of procedures complete to the descending colon was greater and the mean duration of the procedure was shorter. There was no significant difference in polyp detection rates.
  
  
  CONCLUSIONS
  A single phosphate enema self administered around one hour before leaving home is a more acceptable and effective method of preparing the distal bowel for flexible sigmoidoscopy than Picolax.
authors.affiliation: Imperial Cancer Research Fund Colorectal Cancer Unit, St Mark's Hospital, Northwick Park, Harrow HA1 3UJ. atkin@icrf.icnet.uk
authors.forename: W S
authors.initials: WS
authors.lastname: Atkin
authors.forename: A
authors.initials: A
authors.lastname: Hart
authors.forename: R
authors.initials: R
authors.lastname: Edwards
authors.forename: C F
authors.initials: CF
authors.lastname: Cook
authors.forename: J
authors.initials: J
authors.lastname: Wardle
authors.forename: P
authors.initials: P
authors.lastname: McIntyre
authors.forename: R
authors.initials: R
authors.lastname: Aubrey
authors.forename: C
authors.initials: C
authors.lastname: Baron
authors.forename: S
authors.initials: S
authors.lastname: Sutton
authors.forename: J
authors.initials: J
authors.lastname: Cuzick
authors.forename: A
authors.initials: A
authors.lastname: Senapati
authors.forename: J M
authors.initials: JM
authors.lastname: Northover
mesh_terms: D000284:Administration, Oral; D002400:Cathartics / Q000008:administration & dosage*; D002951:Citrates; D004733:Enema / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D010349:Patient Compliance; D017060:Patient Satisfaction; D010710:Phosphates; D010847:Picolines / Q000008:administration & dosage*; D012812:Sigmoidoscopy / Q000379:methods*; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D002400:Cathartics; D002951:Citrates; D009942:Organometallic Compounds; D010710:Phosphates; D010847:Picolines; C005701:picosulfate sodium