Synthesis and NMR characterization of a novel class of thienomorphinans.
[formula: see text] Synthesis of four novel thieno derivatives 4-7 featuring the codeine skeletal backbone is reported. Characterization by 1H and 13C NMR is also discussed, along with binding profile for opioid receptors.
Ronzoni
S
S
SmithKline Beecham S.p.A., Milano, Italy. silvano_ronzoni@sbphrd.com
Cerri
A
A
Dondio
G
G
Fronza
G
G
Petrillo
P
P
Raveglia
L F
LF
Gatti
P A
PA
D002460:Cell Line; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009019:Morphinans / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010207:Papaver / Q000737:chemistry*; D010946:Plants, Medicinal; D011957:Receptors, Opioid / Q000378:metabolism
D008024:Ligands; D009019:Morphinans; D011957:Receptors, Opioid