title: Trans-epithelial intestinal elimination of moxifloxacin in rabbits.
abstract: The intestinal trans-epithelial elimination of moxifloxacin was measured in the jejunum, ileum, caecum and in the bile in a rabbit model. Over a 120 min period following a single parenteral administration of moxifloxacin 15 mg/kg, peak serum concentration was 3.1 (+/- 1.1) mg/L. The elimination constants were: 0.019 (+/- 0. 017) microg/cm(2)/min, 0.011 (+/- 0.014) microg/cm(2)/min and 0.002 (+/- 0.002) microg/cm(2)/min in the jejunum, ileum and caecum, respectively. Per loop, over 120 min, the respective eliminated quantities were: 9.59 (+/- 9.37) microg, 8.26 (+/- 6.74) microg and 1.92 (+/- 1.86) microg. Biliary moxifloxacin concentrations varied between 1.30 and 5.16 mg/L and exceeded serum levels from 45 min onwards. Intestinal concentrations paralleled serum moxifloxacin levels. Altogether, approximately 4.5% of the moxifloxacin dose was eliminated trans-epithelially in the digestive tract over the 120 min experimental period.
authors.affiliation: The Infectious Diseases Unit, and Department of Urology, Chaim Sheba Medical Center, Tel Hashomer 52621, Tel Aviv University School of Medicine, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Musafija
authors.forename: J
authors.initials: J
authors.lastname: Ramon
authors.forename: Y
authors.initials: Y
authors.lastname: Shtelman
authors.forename: G
authors.initials: G
authors.lastname: Yoseph
authors.forename: B
authors.initials: B
authors.lastname: Rubinovitz
authors.forename: S
authors.initials: S
authors.lastname: Segev
authors.forename: E
authors.initials: E
authors.lastname: Rubinstein
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001372:Aza Compounds; D001412:Bacillus subtilis / Q000187:drug effects; D001646:Bile / Q000378:metabolism; D001681:Biological Assay; D004848:Epithelium / Q000378:metabolism; D024841:Fluoroquinolones; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D000077266:Moxifloxacin; D011804:Quinolines; D011817:Rabbits
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin