Molecular genetics of human hypertension.
The year 1999 saw considerable activity in the area of hypertension-related molecular genetics. Several new monogenic hypertensive disorders, as well as a monogenic form of hypotension, were elucidated. Molecular genetics has made significant inroads in explaining basic mechanisms of magnesium homeostasis. Linkage strategies have been applied in family studies, sib-pair analyses, and twin studies. More stringent criteria for association studies have been formulated. The 11 beta-hydroxysteroid dehydrogenase gene, the prostacyclin synthase gene, genes coding for variants in G proteins, and adrenergic receptor genes have received particular attention. On the horizon are better phenotyped patient and subject collectives, expanded genotyping with the availability of a 300,000 genome-wide single-nucleotide polymorphism map, multigenic studies in the form of metabolic control analyses, and new bioinformatic strategies including neural networks.
Luft
F C
FC
Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, Germany. luft@fvk-berlin.de
D042842:11-beta-Hydroxysteroid Dehydrogenases; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D019204:GTP-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D008040:Genetic Linkage; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics; D006973:Hypertension / Q000235:genetics*; D019746:Intramolecular Oxidoreductases / Q000235:genetics; D011941:Receptors, Adrenergic / Q000235:genetics
D011941:Receptors, Adrenergic; D003577:Cytochrome P-450 Enzyme System; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D019204:GTP-Binding Proteins; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase