Translational frameshift sites within bacteriophage lambda genes rexA and cI.
Phage lambda's cI-rexA-rexB operon displays an intriguing example of regulation by an unexplained mechanism of polarity. We have identified three potential -1 translational frameshift sites and present a model for translational frameshift suppression by lambda's CI repressor as a mechanism of regulating operon polarity, implying an additional role for CI self-regulation.
Hayes
S
S
Department of Microbiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Bull
H J
HJ
D010582:Bacteriophage lambda / Q000235:genetics* / Q000254:growth & development; D001483:Base Sequence; D004268:DNA-Binding Proteins; D018965:Frameshifting, Ribosomal; D015967:Gene Expression Regulation, Viral; D005814:Genes, Viral; D008242:Lysogeny / Q000235:genetics; D008957:Models, Genetic; D009154:Mutation; D009876:Operon; D010641:Phenotype; D012367:RNA, Viral / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D017361:Viral Nonstructural Proteins / Q000235:genetics; D014764:Viral Proteins / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins; D014775:Virus Activation / Q000235:genetics
D004268:DNA-Binding Proteins; D012367:RNA, Viral; D012097:Repressor Proteins; C094107:RexA protein, Bacteriophage lambda; D017361:Viral Nonstructural Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C016649:phage repressor proteins