title: Chlamydia, inflammation, and atherogenesis.
abstract: Atherosclerotic lesions are initiated and progress largely as a result of a chronic, fibroproliferative, inflammatory response. This review discusses how Chlamydia pneumoniae could conceivably contribute to this chronic inflammatory response and reports on recent in vivo and in vitro studies. In vivo studies in mice demonstrate that C. pneumoniae infection is disseminated to the artery wall following infection in the lung by alveolar macrophages. Recent in vitro studies show that infected U937 cells can directly transfer infection to endothelial cells and can indirectly increase the susceptibility of endothelial cells to C. pneumoniae infection. Loading of RAW 264.7 cells with modified forms of low-density lipoprotein increases the resistance of the cells to C. pneumoniae infection and also increases the susceptibility to the combined toxic effects of modified lipids and C. pneumoniae infection.
authors.affiliation: Department of Pathobiology and Interdisciplinary Graduate Program in Nutritional Sciences, University of Washington, Seattle, WA 98195. ssmjm@u.washington.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Rosenfeld
authors.forename: E
authors.initials: E
authors.lastname: Blessing
authors.forename: T M
authors.initials: TM
authors.lastname: Lin
authors.forename: T C
authors.initials: TC
authors.lastname: Moazed
authors.forename: L A
authors.initials: LA
authors.lastname: Campbell
authors.forename: C
authors.initials: C
authors.lastname: Kuo
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D002478:Cells, Cultured; D002690:Chlamydia Infections / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000503:physiopathology*; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000276:immunology; D050356:Lipid Metabolism; D051379:Mice; D008810:Mice, Inbred C57BL