Cell kinetics in a tumour cord.
In some tumours, the viable cells grow around blood vessels forming cylindrical structures called tumour cords, which are surrounded by regions of necrosis. In the present paper, we propose a mathematical model for the cell kinetics in a tumour cord at the stationary state. Both proliferating cells and quiescent cells are considered, and the proliferating cell population is structured by age. Cell migration towards cord periphery is accounted for from a continuum viewpoint. The age distribution of proliferating cells, the fraction of cells in S phase, the growth fraction and the velocity along the cord radius are computed. The predictions of the model are compared with literature data obtained from two experimental rat hepatomas. The model was used to compute the profile of the oxygen tension within the cord. Possible modifications and extensions are also presented.
Bertuzzi
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Istituto di Analisi dei Sistemi ed Informatica del CNR, Viale Manzoni 30, Roma, 00185, Italy. bertuzzi@iasi.rcm.cnr.it
Gandolfi
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D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000473:pathology*; D002455:Cell Division; D002465:Cell Movement; D003198:Computer Simulation; D008113:Liver Neoplasms / Q000098:blood supply / Q000473:pathology*; D008954:Models, Biological; D009385:Neoplastic Processes; D051381:Rats