[Manifestations of pulmonary tuberculosis concurrent with diabetes mellitus and various haptoglobin phenotypes].
For diagnosis, detection of the specific manifestations of pulmonary tuberculosis (PT) concurrent with diabetes mellitus, 48 patients with insulin-dependent diabetes (IDD) and 132 with noninsulin-dependent diabetes (NIDD), who carry various haptoglobin (Hp) phenotypes were studied. It has been found that PT develops in IDD mainly in 5-10 years and in NIDD in 1-4 years. The gravest course of both types of diabetes is frequently encountered in those having Hp 2-2 phenotypes and slightly less frequently in those with Hp 1-1. The patients having these phenotypes have abnormalities in the levels of glycaric hemoglobin, 2.3-diphosphoglycerol phosphate, in the activity of the enzymes lactate dehydrogenase and glucose-6-phosphate dehydrogenase and acid-alkali imbalance. It is expedient to determine Hp phenotypes to evaluate the severity and prognosis and to choose a treatment policy for comorbidity and the proposed biochemical indices should be more widely used to evaluate carbohydrate metabolic disturbances in PT concurrent with diabetes mellitus.
Ubaĭdullaev
A M
AM
Kazakov
K S
KS
Parpieva
N N
NN
D000293:Adolescent; D000328:Adult; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006442:Glycated Hemoglobin / Q000235:genetics / Q000378:metabolism; D006242:Haptoglobins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000150:complications* / Q000235:genetics
D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase; D006442:Glycated Hemoglobin; D006242:Haptoglobins; D007770:L-Lactate Dehydrogenase