Immunomodulating properties of the diterpene andalusol.
Andalusol [ent-13(16),14-labdadiene-6 alpha,8 alpha,18-triol], a labdane diterpene isolated from an anti-inflammatory extract of the medicinal plant Sideritis foetens Clem. was evaluated for immunomodulating properties. It exhibited a dose-dependent inhibitory effect on the hemolytic activity of the classical complement pathway and also inhibited lymphocyte proliferation induced by concanavalin A at non-cytotoxic concentrations (1-100 microM). No effect on the alternative pathway was observed. These results indicate that andalusol has immunosuppressive effects in vitro in addition to its anti-inflammatory activity.
Navarro
A
A
de las Heras
B
B
Villar
A
A
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects; D051379:Mice; D051381:Rats
D000276:Adjuvants, Immunologic; D003169:Complement Inactivator Proteins; D004224:Diterpenes; C110596:ent-13(16),14-labdadiene-6,8,18-triol