title: A glucose transporter chimera confers a dominant negative glucose starvation phenotype in Saccharomyces cerevisiae.
abstract: A family of glucose transporters mediates glucose uptake in Saccharomyces cerevisiae. We show that the dominant mutation GSF4-1, which impairs glucose repression of SUC2, results in a nonfunctional chimera of the transporters Hxt1p and Hxt4p. Hxt1/4p inhibits the function of wild-type glucose transporters. Similar mutations may facilitate analysis of the major facilitator superfamily.
authors.affiliation: Department of Genetics and Development, Columbia University, New York, NY 10032, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Sherwood
authors.forename: I
authors.initials: I
authors.lastname: Katic
authors.forename: P
authors.initials: P
authors.lastname: Sanz
authors.forename: M
authors.initials: M
authors.lastname: Carlson
mesh_terms: D001483:Base Sequence; D002678:Chimera; D004271:DNA, Fungal; D005947:Glucose / Q000378:metabolism*; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D010641:Phenotype; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism
chemical_list: D004271:DNA, Fungal; D009004:Monosaccharide Transport Proteins; D005947:Glucose