[The role of antioxidative status in development of the consequences of biological action under low dose and low intensity irradiation].
The scale and direction of changes of a number of biophysical, biochemical and physiological parameters in SHK mice (male) tissues were studied depending on their initial values for mice control groups within 1 day after low intensity gamma-irradiation (15 cGy). The reciprocal dependences between the scales of the lipid antioxidative activity (AOA) in brain or the spleen mass changes and their values for mice control groups were found. The external dependences were revealed between the amounts of lipid peroxidation secondary products in spleen, liver and blood plasma of the control mice and a scale of their change after irradiation. The most substantial changes of this parameter were observed in blood plasma and the changes of the phospholipid content within the total lipid composition were found in spleen and blood erythrocytes of the irradiated mice, that is in the lipids of tissues, which had the lowest level of AOA for mice control groups. The experimental data obtained indicate that the initial antioxidant status of animal tissues plays the important role for the development of consequences of the biological action under low dose and low intensity irradiation.
Shishkina
L N
LN
Emanual Institute of Biochemical Physics, Russian Academy of Science, Moscow.
Kushnireva
E V
EV
Bespal'ko
O F
OF
Poliakova
N V
NV
D000222:Adaptation, Physiological; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008297:Male; D051379:Mice; D009928:Organ Specificity; D014916:Whole-Body Irradiation
D000975:Antioxidants