title: Anti-inflammatory and analgesic activities of the latex containing triterpenes from Himatanthus sucuuba.
abstract: Some triterpenes and iridoids were previously isolated from the stem bark of Himatanthus sucuuba. The latex from Himatanthus sucuuba is used in popular amazonian medicine as an anti-inflammatory remedy. Fractions of the latex were pharmacologically evaluated with a view to verify this popular use in the carrageenan-induced rat paw edema and in the acetic acid-induced mouse constriction tests. The hexane fraction inhibited the edema formation by 35.9% at a dose of 200 mg/kg (p.o.) but no activity was observed at 100 mg/kg (p.o.). The triterpenes present in the hexane fraction were identified as lupeol acetate, alpha-amyrin and lupeol cinnamates. The fraction containing only cinnamates inhibited the edema and the abdominal constrictions by 50-40% and 57.9%, respectively, at 100 mg/kg (p.o.). Among all the fractions studied, the fraction containing only cinnamates showed the greatest anti-inflammatory activity which suggests that these compounds were responsible for the previously described activity of the crude extract.
authors.forename: A L
authors.initials: AL
authors.lastname: de Miranda
authors.forename: J R
authors.initials: JR
authors.lastname: Silva
authors.forename: C M
authors.initials: CM
authors.lastname: Rezende
authors.forename: J S
authors.initials: JS
authors.lastname: Neves
authors.forename: S C
authors.initials: SC
authors.lastname: Parrini
authors.forename: M L
authors.initials: ML
authors.lastname: Pinheiro
authors.forename: M C
authors.initials: MC
authors.lastname: Cordeiro
authors.forename: E
authors.initials: E
authors.lastname: Tamborini
authors.forename: A C
authors.initials: AC
authors.lastname: Pinto
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D007840:Latex / Q000032:analysis*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000494:pharmacology*
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007840:Latex; D014315:Triterpenes