title: Synthesis and DNA binding of spirocyclic model compounds related to the neocarzinostatin chromophore.
abstract: [formula: see text] Spirocyclic model compounds which mimic the molecular architecture of one of the decomposition products of the antitumor agent NCS-chrom have been synthesized. These readily accessible molecules bind with remarkable efficiency to bulged DNA oligonucleotides, offering potential for the design of therapeutic agents.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Xi
authors.forename: G B
authors.initials: GB
authors.lastname: Jones
authors.forename: G
authors.initials: G
authors.lastname: Qabaja
authors.forename: J
authors.initials: J
authors.lastname: Wright
authors.forename: F
authors.initials: F
authors.lastname: Johnson
authors.forename: I H
authors.initials: IH
authors.lastname: Goldberg
mesh_terms: D004247:DNA / Q000378:metabolism*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008956:Models, Chemical; D013237:Stereoisomerism; D009353:Zinostatin / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D004247:DNA; D009353:Zinostatin