title: The efficacy of sublingual verapamil in controlling rapid ventricular rate in chronic atrial fibrillation.
abstract: The efficacy of sublingual verapamil (Verapabene, 40 mg) in acute control of high ventricular rate was assessed in 20 patients with chronic atrial fibrillation (AF) of ischemic origin (class NYHA II and III). The effect on irregularity of the rhythm was also studied using time domain parameters of heart rate variability. Four ECG recordings (before, and at 10, 30 and 60 minutes after the administration), of 10 minutes each, were performed in every patient in basal conditions. The parameters were compared using paired t-test and Wilcoxon's test. Mean heart rate became significantly lower (p = 0.0064) after 10 minutes, and reached progressively the lowest value after 60 minutes (from the initial 112.9 beats/min to 90.6 beats/min, after 60 minutes, p < 0.0001). The irregularity parameters (SDNN--from 114.7 ms to 148.6 ms, rMSSD--from 152 ms to 205.9 ms) and the NNmin interval (from 353 ms to 404.5 ms) increased significantly after 30 and 60 minutes (p < 0.0001), but the frequency corrected irregularity (coefficient of variability) remained unchanged (p > 0.4). Sublingually administered verapamil proved to be an efficient alternative in acute control of rapid ventricular rate in AF. The method has the advantage to be applicable by a properly instructed patient itself.
authors.affiliation: Third Medical Clinic, University of Medicine and Pharmacy, Târgu-Mureş, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Incze
authors.forename: A
authors.initials: A
authors.lastname: Frigy
authors.forename: S
authors.initials: S
authors.lastname: Cotoi
mesh_terms: D000286:Administration, Sublingual; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000503:physiopathology; D002908:Chronic Disease; D004562:Electrocardiography / Q000187:drug effects / Q000706:statistics & numerical data; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D018709:Statistics, Nonparametric; D013997:Time Factors; D014700:Verapamil / Q000008:administration & dosage*
chemical_list: D000889:Anti-Arrhythmia Agents; D014700:Verapamil