[Oscillations in the oxidation-reduction potential of the brain tissue in rats developing during wakefulness and slow-wave sleep].
Variations of the brain cortex redox state potential (E) were recorded in freely moving white rats (mass of 300-350 g) with implanted platinum electrodes (with the platinum reference electrode in the nasal bone) during sleep-wake cycles. It was found that transitions from the slow-wave sleep to wakefulness were accompanied in the number of cortical areas (metabolic-active sites) by the E rise, while the transitions from the wakefulness to slow-ware sleep were associated with a drop of E. However, the episodes of the short-term arousals during the slow-wave sleep were accompanied by the respective decreases in E thus forming the irregular E variations (1.5-3 min in duration). It was also found that the oscillations of a typical pattern (quasisinusoidal with the frequency of 10-20 osc/min and the amplitudes up to several mV) could take place in the metabolic-active cortical sites. These oscillations were defined as fast E oscillations. During the slow-wave sleep, the less regular oscillations with the lower frequency (1.2-10 osc/min) and higher amplitude were recorded in the same cortical sites. These oscillations were defined as slow. It is suggested that the fast metabolic oscillations of wakefulness are mainly controlled by the mitochondria of neuronal populations, whereas the slow metabolic oscillations which occur in the slow-wave sleep are related with glycolysis in populations of glial cells.
Shvets-Ténéta-Guriĭ
T B
TB
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.
Troshin
G I
GI
Dubinin
A G
AG
Novikova
M R
MR
D000818:Animals; D001450:Ballistocardiography; D001921:Brain / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004734:Energy Metabolism / Q000502:physiology; D010084:Oxidation-Reduction; D010313:Partial Pressure; D051381:Rats; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology*