Identification and characterization of a potent antibacterial agent, NH125 against drug-resistant bacteria.
New imidazole compounds were synthesized to develop a novel and effective antibacterial agent (1-benzyl-3-cetyl-2-methylimidazolium iodide, NH125). In vitro experiments demonstrated that NH125 effectively inhibited a number of different histidine protein kinases. Furthermore, oxacillin-resistant Staphylococcus aureus (ORSA), vancomycin-resistant Enterococcus faecalis (VRE), penicillin-resistant Streptococcus pneumoniae (PRS), and other Gram-positive and Gram-negative bacteria were found to be very sensitive to NH125.
Yamamoto
K
K
Department of Agricultural Chemistry, Kinki University, Nara, Japan.
Kitayama
T
T
Ishida
N
N
Watanabe
T
T
Tanabe
H
H
Takatani
M
M
Okamoto
T
T
Utsumi
R
R
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D000071677:Histidine Kinase; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007093:Imidazoles; C414024:NH 125; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D000071677:Histidine Kinase