The development of efficient protocols for the palladium-catalyzed cyclization reactions of secondary amides and carbamates.
[formula: see text] With the proper choice of palladium catalyst, ligand, and base, five-, six-, and seven-membered rings are formed efficiently from secondary amide or secondary carbamate precursors, offering significant improvements to currently existing methodology.
Yang
B H
BH
Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.
Buchwald
S L
SL
D000577:Amides / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D002614:Chelating Agents; D003500:Cyclization; D008024:Ligands; D010165:Palladium / Q000737:chemistry*
D000577:Amides; D002219:Carbamates; D002614:Chelating Agents; D008024:Ligands; D010165:Palladium