title: Early hyperlactataemia in critically ill children.
abstract: OBJECTIVE
  To examine the relationships between early hyperlactataemia, acidosis, organ failure, and mortality in children admitted to intensive care.
  
  
  METHODS
  Prospective observational study. Children with lactate levels > 2 mmol/l were eligible for enrolment. Post-operative patients and those with inherited metabolic disease were excluded. Seven hundred and five children admitted to intensive care were screened, and 50 children with hyperlactataemia (incidence 7%), aged 20.3 months (0.1-191) were enrolled and followed up. The Paediatric Risk of Mortality (PRISM) score, Multiorgan System Failure (MOSF) score, length of ICU stay, and outcome were recorded. Data were collected for lactate (mmol/l), pH, and base excess (BE) until 24 h after admission. Data are reported as median (range) and were analysed by the Mann-Whitney, Fisher's Exact, and Kruskal-Wallis tests, and chisquared test for trend.
  
  
  RESULTS
  Overall mortality in the screening group was 70/705 (10%). In the study group (n = 50) median PRISM score was 19 (4-49), median MOSF score 2 (1-4), and observed mortality 32/50 (64%). Median duration of ICU stay was 6 days (2-32) in survivors, and median time until death 3 days (0-13) in nonsurvivors. Eleven nonsurvivors (34%) died within 24 h. In the screening group, hyperlactataemia on admission identified mortality with likelihood ratio = 15. In the study group, neither the admission lactate (3.8 vs 4.6 mmol/l, P = 0.27), pH (7.32 vs 7.30, P = 0.6), nor BE (-7.5 vs -8, P = 0.45) differed significantly between survivors and nonsurvivors. Neither the admission nor peak lactate increased with increasing MOSF score (P = 0.5 and 0.54). The median peak lactate level was 5 mmol/l (2-9.3) in survivors compared to 6.8 mmol/l (2.3-22) in nonsurvivors (P = 0.02), and the cumulative average lactate level was 2.4 mmol/l (1-4.9) in survivors, compared to 4.5 mmol/l (1.6-21) in nonsurvivors (P = 0.0003). Persistent hyperlactataemia 24 h after admission identified mortality with likelihood ratio = 7.
  
  
  CONCLUSIONS
  Hyperlactataemia on admission to intensive care is associated with a high mortality in children. Nonsurvivors within this group may be distinguished by the peak lactate level, or by persistent hyperlactataemia after 24 h of treatment.
authors.affiliation: Paediatric Intensive Care Unit, Guy's Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Hatherill
authors.forename: A G
authors.initials: AG
authors.lastname: McIntyre
authors.forename: M
authors.initials: M
authors.lastname: Wattie
authors.forename: I A
authors.initials: IA
authors.lastname: Murdoch
mesh_terms: D000140:Acidosis, Lactic / Q000097:blood / Q000209:etiology* / Q000401:mortality*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016638:Critical Illness; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D019344:Lactic Acid / Q000097:blood; D007902:Length of Stay; D008131:London / Q000453:epidemiology; D008297:Male; D011446:Prospective Studies
chemical_list: D019344:Lactic Acid