Solid-phase enzymatic synthesis of oligonucleotides.
[formula: see text] The controlled and selective synthesis of oligonucleotides on the solid phase is possible under mild aqueous conditions using the enzyme T4 RNA ligase, the resins being tentagel or kieselguhr/polydimethylacrylamide.
Schmitz
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Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany.
Reetz
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MT
D017931:DNA Primers; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011130:RNA Ligase (ATP)
D017931:DNA Primers; D009841:Oligonucleotides; D011130:RNA Ligase (ATP)