Prepulse inhibition of the blink reflex by laser stimuli in normal humans.
The subcortical integrative effects of laser-induced activation of pain ascending tracts were examined in 11 healthy volunteers, aged 22-52 years. Subjects underwent either CO2 laser stimulation at the dorsum of the hand, electrical stimulation of digital nerves at the 3rd finger, or mechanical taps to the first dorsal interosseous space, preceding a blink reflex elicited by a supraorbital nerve electrical stimulus. The percentage inhibition induced in the R2 response of the blink reflex was similar for the three different stimulus modalities, but occurred at a different time interval. Compared to control trials, the R2 response of the test trials was a mean of 23.1% at the interval of 250 ms with laser stimuli, 17.4% at the interval of 100 ms with electrical stimuli to the 3rd finger, and 20.6% at the interval of 90 ms with a mechanical tap to the 1st interosseous space. Activation of pain receptors induces prepulse inhibition of the blink reflex at a delay corresponding to a slowly conducting pathway. The percentage inhibition is similar to that observed with other somatosensory inputs.
Valls-Solé
J
J
Institut d'Investigacio Biomedica August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain. valls@medicina.ub.es
Veciana
M
M
Serra
J
J
Cruccu
G
G
Romaniello
A
A
D000328:Adult; D001767:Blinking / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007834:Lasers; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000502:physiology*; D009619:Nociceptors / Q000166:cytology* / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000502:physiology; D010812:Physical Stimulation; D011930:Reaction Time / Q000502:physiology; D012154:Reticular Formation / Q000166:cytology / Q000502:physiology*; D013133:Spinothalamic Tracts / Q000166:cytology / Q000502:physiology; D013997:Time Factors