En route to a plant scale synthesis of the promising antitumor agent 12,13-desoxyepothilone B.
[reaction--see text] Efficient and processable syntheses of key building blocks of the antitumor agent 12,13-desoxyepothilone B (dEpoB) by catalytic asymmetric induction are herein described.
Chappell
M D
MD
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, New York, NY 10021, USA.
Stachel
S J
SJ
Lee
C B
CB
Danishefsky
S J
SJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000191:economics; D034261:Epothilones; D004852:Epoxy Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000191:economics; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000191:economics
D000970:Antineoplastic Agents; D034261:Epothilones; D004852:Epoxy Compounds; D007783:Lactones; D013844:Thiazoles; C114026:desoxyepothilone B; C093788:epothilone B