Resolution and synthesis of optically active alcohols with immobilized water-soluble proteins from green pea, soybean and buckwheat as new bio-catalysts.
Kinetic resolution of racemic alcohols, (+/-)-1-(4-substituted phenyl)ethanol and (+/-)-1-(2-naphthyl)ethanol, was done with immobilized green pea, soybean, or buckwheat proteins. The resolution was done stereoselectively by oxidizing only one enantiomer of a racemic alcohol to leave an optically active alcohol with a high purity. In addition, each protein could be reused consecutively at least three times without any decrease of yield or optical purity.
Nagaoka
H
H
The United Graduate School of Agricultural Science, Gifu University, Japan.
Kayahara
H
H
D000438:Alcohols / Q000737:chemistry; D000431:Ethanol / Q000031:analogs & derivatives* / Q000737:chemistry; D019612:Fagopyrum / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry*; D010084:Oxidation-Reduction; D018532:Pisum sativum / Q000737:chemistry*; D010940:Plant Proteins / Q000737:chemistry*; D012995:Solubility; D013025:Glycine max / Q000737:chemistry*; D014867:Water
D000438:Alcohols; D009281:Naphthalenes; D010940:Plant Proteins; D014867:Water; C403616:1-(2-naphthyl)ethanol; D000431:Ethanol