Gastric anti-ulcer activity of several alpha,beta-unsaturated carbonyl compounds in rats.
The gastric cytoprotective activity of several molecules containing an alpha,beta-unsaturated carbonyl system is reported. We attributed this gastroprotective activity to the presence of a non-hindered Michael acceptor in the molecules assayed and suggested that the mechanism of protection would involve, at least in part, a nucleophilic attack of the sulphydryl group of the gastric mucosa to the beta carbon of the Michael acceptors of the compounds assayed.
Maria
A O
AO
Departamento de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina. alemaria@unsl.edu.ar
Donadel
S
S
Wendel
G H
GH
Guzman
J A
JA
Guerreiro
E
E
Giordano
O S
OS
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D003517:Cyclopentanes / Q000737:chemistry / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects; D020011:Protective Agents / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D000897:Anti-Ulcer Agents; D003517:Cyclopentanes; D020011:Protective Agents; C014096:alpha-methylene gamma-butyrolactone; D015107:4-Butyrolactone; C013905:cyclopentenone