title: [Effectiveness of carboplatin and etoposide selective intra-arterial chemotherapy for progressive soft-tissue sarcoma].
abstract: Four patients with advanced soft tissue sarcomas were treated by selective intra-arterial injection of carboplatin (450 mg/m2/2 hr) and etoposide (200 mg/m2/2 hr). After 2-4 courses of treatment, tumor size was remarkably reduced. Three of the 4 patients became candidates for limb-salvage surgery with a safety margin. During the treatment, patients showed no significant complications except for slight nausea and myelosuppression. This protocol might be a recommendable treatment for advanced soft tissue sarcomas.
authors.affiliation: Dept. of Orthopaedic Surgery, Aichi Cancer Center.
authors.forename: T
authors.initials: T
authors.lastname: Hamana
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Miyagi
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D012509:Sarcoma / Q000188:drug therapy*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy*
chemical_list: D005047:Etoposide; D016190:Carboplatin