Interaction of monensin and sulfadimethoxine in broilers, as mediated by hepatic microsomal cytochrome P-450 monooxygenases.
The influence of monensin + sulfadimethoxine on cytochrome P-450 monooxygenase activity in broilers, and the possible consequences of modification of this system, including changes in blood levels of sulfadimethoxine, influence on the duration of xylazine-ketamine anesthesia, total antioxidant status and superoxide dismutase activity were studied. The results indicate that the combination of monensin + sulfadimethoxine gave a short-term inhibition of microsomal cytochrome P-450 monooxygenase activity but apparently did not influence the metabolism of other (exogenic) substances (ketamine, xylazine), and did not change the state of antioxidant systems or the relative liver weight. There was a rise in blood sulfadimethoxine levels.
Ershov
E
E
Kimron Veterinary Institute, Bet Dagan, Israel.
Bellaiche
M
M
Hanji
V
V
Soback
S
S
Gips
M
M
Weisman
Y
Y
Shlosberg
A
A
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000378:metabolism; D002645:Chickens / Q000378:metabolism*; D003049:Coccidiostats / Q000494:pharmacology; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D008985:Monensin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D013412:Sulfadimethoxine / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000975:Antioxidants; D003049:Coccidiostats; D065607:Cytochrome P-450 Enzyme Inhibitors; D013412:Sulfadimethoxine; D003577:Cytochrome P-450 Enzyme System; D008985:Monensin