title: Effects of tri-o-cresyl phosphate on serum estrogen and progesterone concentration and ATPase activity in the shell gland of adult hens.
abstract: The activities of calcium-activated ATPase (Ca2+-ATPase) and calcium magnesium-activated ATPase (Ca2+-Mg2+-ATPase) in the shell gland, and concentrations of 17beta-estradiol (E2) and progesterone in serum were monitored, respectively, from hens orally dosed with tri-o-cresyl phosphate (TOCP) (750 mg/kg). Treated birds were monitored daily for laying and development of delayed neurotoxicity, and activities of Ca2+-ATPase and Ca2+-Mg2+-ATPase were measured at 7 and 10 days after dosing. TOCP-treated birds manifested motor deficit by 7-9 days postdosing, while hens administered vehicle exhibited no signs of delayed neurotoxicity. Ca2+-ATPase and Ca2+-Mg2+-ATPase activities of shell glands from TOCP-dosed hens were not significantly affected (P > 0.05). The serum E2 concentration was significantly reduced in TOCP-treated hens (P < 0.01); however, progesterone levels were unaffected.
authors.affiliation: Department of Toxicology, Institute of Zoology, Academia Sinica, Beijing, People's Republic of China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Wu
authors.forename: X F
authors.initials: XF
authors.lastname: Leng
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017301:Ca(2+) Mg(2+)-ATPase / Q000187:drug effects / Q000378:metabolism*; D002645:Chickens; D004958:Estradiol / Q000097:blood* / Q000378:metabolism; D005260:Female; D009043:Motor Activity; D009498:Neurotoxins / Q000009:adverse effects / Q000494:pharmacology; D011374:Progesterone / Q000097:blood* / Q000378:metabolism; D014317:Tritolyl Phosphates / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D009498:Neurotoxins; D014317:Tritolyl Phosphates; D011374:Progesterone; D004958:Estradiol; D017301:Ca(2+) Mg(2+)-ATPase; C025541:tri-o-cresyl phosphate