Correlation of circulating 17beta-oestradiol with haemostatic factors in healthy postmenopausal women.
The aim of the study was to evaluate any correlation between the circulating oestrogenic hormone 17beta-oestradiol and haemostatic factors in healthy postmenopausal women. In keeping with this objective, the correlations were evaluated irrespective of whether the source of the hormone was purely endogenous or exogenous as well. Accordingly, a univariate correlation adjusted for age, body mass index, and duration of menopause was determined in 42 healthy postmenopausal women aged 47-78 years, 19 of whom were self-reported users of hormone replacement therapy. The rest were self- reported never users. Serum 17beta-oestradiol exhibited a direct correlation with endogenous thrombin potential extrinsic pathway (R = 0.42, p = 0.01) and prothrombin fragments 1 and 2 (R = 0.37, p = 0.03) and an inverse correlation with antithrombin III (R = -0.36, p = 0.03) and alpha(2)-antiplasmin (R = -0.45, p = 0.005). The observations suggest an association of this hormone with net thrombin generation on the one hand and improved fibrinolysis on the other.
Mukherjee
M
M
Thrombosis Research Institute, London, UK. manjarimukherjee@yahoo.com/cch@bom7.vsnl.net.in
De Lorenzo
F
F
Kadziola
Z
Z
Rutlin
A
A
Ranlall
N
N
Sembhi
K
K
Dawson
G
G
Kakkar
V V
VV
DeLorenzo
F
F
D000328:Adult; D000367:Age Factors; D000990:Antithrombin III / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000378:metabolism*; D015992:Body Mass Index; D004958:Estradiol / Q000097:blood*; D005167:Factor VII / Q000378:metabolism; D005260:Female; D006487:Hemostasis; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism; D017698:Postmenopause / Q000097:blood*; D011516:Prothrombin / Q000378:metabolism; D018709:Statistics, Nonparametric; D000979:alpha-2-Antiplasmin / Q000378:metabolism
D001779:Blood Coagulation Factors; D010446:Peptide Fragments; D000979:alpha-2-Antiplasmin; C045879:prothrombin fragment 1.2; D004958:Estradiol; D000990:Antithrombin III; D005167:Factor VII; D011516:Prothrombin