title: Prenatal diagnosis of abnormalities of the fetal venous system.
abstract: OBJECTIVE
  To present our experience in the prenatal diagnosis of anomalies of fetal veins using high-resolution color Doppler ultrasound.
  
  
  METHODS
  An observational study of 16 fetuses with abnormalities of the umbilical, portal, hepatic and caval venous system being diagnosed at the Division of Prenatal Diagnosis and Therapy (Bonn, Germany) over the past 5 years. The abnormality of the venous system, the underlying embryologic disorder and the outcome of the pregnancy are presented and compared with the literature.
  
  
  RESULTS
  In group A, eight fetuses had an abnormal course of the umbilical vein with a patent (n = 3) or absent (n = 5) ductus venosus. No portal veins and absent or abnormal hepatic veins were visualized by color Doppler sonography. Six fetuses (75%) did not have an associated malformation and have survived. Two pregnancies with fetal hydrops due to a small heart and to Turner's syndrome were terminated or ended in fetal demise. In group B, seven of eight fetuses with an abnormal caval system had a situs ambiguus or an atrial isomerism. A cardiac defect was detected in six cases (86%). These six pregnancies ended in four terminations of pregnancy and two infant deaths due to the severity of the congenital cardiac defect. One child with a normal heart and a child with an isolated abnormal course of the lower inferior vena cava are developing well.
  
  
  CONCLUSIONS
  In a targeted fetal scan the course of the umbilical vein, ductus venosus, the portal and hepatic veins and inferior vena cava should be carefully examined using color Doppler. Any suspicious finding should be followed by a detailed assessment of the specificity of this abnormality taking into consideration the embryologic development of the fetal venous system together with the associated malformations.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bonn, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Hofstaetter
authors.forename: H
authors.initials: H
authors.lastname: Plath
authors.forename: M
authors.initials: M
authors.lastname: Hansmann
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006503:Hepatic Veins / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology; D006801:Humans; D011169:Portal Vein / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology; D012189:Retrospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color; D016216:Ultrasonography, Prenatal; D014471:Umbilical Veins / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology; D014682:Vena Cava, Inferior / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology