Stimulation of platelets and endothelial cells by mildly oxidized LDL proceeds through activation of lysophosphatidic acid receptors and the Rho/Rho-kinase pathway. Inhibition by lovastatin.
Essler
M
M
Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Universität München, Germany.
Retzer
M
M
Bauer
M
M
Zangl
K J
KJ
Tigyi
G
G
Siess
W
W
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D004727:Endothelium / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008148:Lovastatin / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000819:agonists*; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; D015398:Signal Transduction / Q000187:drug effects; D054460:rho-Associated Kinases
D047908:Intracellular Signaling Peptides and Proteins; D008077:Lipoproteins, LDL; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; C099252:oxidized low density lipoprotein; D008148:Lovastatin; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases