Pulsatile release from subcutaneous implants.
Pulsatile delivery of antigens and hormones from subcutaneous implants could have uses in the animal production and veterinary medicine. Development of single-shot vaccines which release both initial and booster antigen from a single administration and hormonal preparations that release in a similar manner to the natural secretion patterns are two areas with potential. Formulation approaches employed to produce subcutaneous implants with pulsatile release profiles are reviewed.
Medlicott
NJ
School of Pharmacy, University of Otago, P.O. Box 913, Dunedin, New Zealand
Tucker
IG