Outcome assessment in cancer management.
The goals of cancer treatment may be prevention, cure, or palliation. In each case, the length and quality of survival are the ultimate outcomes to assess when evaluating the success of treatment. Some surrogate or intermediate endpoints, however, may be considered, such as toxicity or the tumor response. The first section of this article considers traditional outcomes and endpoints and intermediate or surrogate endpoints for survival and quality of life. The second section specifically addresses the issue of the quality-of-life outcome, which has become increasingly important over the last 2 decades. The last section suggests that combining survival and quality of life may not be easy. Costs are increasingly important in management of diseases, and the outcomes of cancer treatment frequently are measured against them. Although the definitions of cost-effectiveness and cost-utility are mentioned at the end of this article, the article does not deal with the problems of decision making for health resource allocation.
Tamburini
M
M
Units of Psychology, Istituto Nazionale Tumori, Milan, Italy.
Casali
P G
PG
Miccinesi
G
G
D000970:Antineoplastic Agents / Q000009:adverse effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000601:surgery*; D011788:Quality of Life; D015996:Survival Rate; D016896:Treatment Outcome
D000970:Antineoplastic Agents