Minireview: mechanisms by which the metabolic syndrome and diabetes impair memory.
Type 2 diabetes is associated with an increased risk of cognitive dysfunction. These effects seem particularly true for memory functions. This article examines how diabetes and the biological changes that occur with diabetes such as hyperglycemia, changes in insulin concentration, hypertension, and changes in lipid levels might lead to these alterations in cognitive functioning, with an emphasis on the mechanisms leading to changes in memory.
Kumari
M
M
International Centre for Health and Society, Department of Epidemiology and Public Health, Royal Free and University College Medical School, London. m.kumari@public-health.ucl.ac.uk
Brunner
E
E
Fuhrer
R
R
D003704:Dementia / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D006946:Hyperinsulinism / Q000150:complications; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology; D012307:Risk Factors