Efficient enantioselective synthesis of sertraline, a potent antidepressant, via a novel intramolecular nucleophilic addition to imine.
[formula: see text] An efficient enantioselective synthesis of sertraline, an antidepressant, utilizing anionic imine ring closure is described.
Chen
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Process Research Department, Merck Research Laboratories, Rahway, New Jersey 07065, USA. cheng_chen@merck.com
Reamer
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D018687:Antidepressive Agents, Second-Generation / Q000138:chemical synthesis*; D007097:Imines / Q000737:chemistry; D020280:Sertraline / Q000138:chemical synthesis*; D013237:Stereoisomerism
D018687:Antidepressive Agents, Second-Generation; D007097:Imines; D020280:Sertraline