Behavioral effect of mouse fibrinopeptide A on mouse forced swimming.
A specific dopamine 2 receptor antagonist, (-)sulpiride, induced an anti-depressive behavior, climbing, in mice forced to swim for 6 h after the injection. The effective fraction was divided from the mouse serum using an ion exchanger and an ultra filtration method. This fraction contained fibrinopeptide A. A peptide synthesized according to the primary 6-amino acid sequence (TDTEDK) of fibrinopeptide A also remarkably increased the behavior. The present findings clearly indicate that a peptide with TDTEDK showed anti-depressive activity.
Masuda
Y
Y
Psychosomatic Division, Akita University School of Medicine, Hondo 1-1-1, 010-8543, Akita, Japan.
Kawarada
Y
Y
Sugiyama
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D005344:Fibrinopeptide A / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology*; D013550:Swimming
D000928:Antidepressive Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; D010446:Peptide Fragments; D005344:Fibrinopeptide A; D013469:Sulpiride