title: Group therapy for patients with bipolar disorder and substance dependence: results of a pilot study.
abstract: BACKGROUND
  The authors' goal was to pilot test a newly developed manual-based group psychotherapy, called Integrated Group Therapy (IGT), for patients with bipolar disorder and substance dependence.
  
  
  METHODS
  In this open trial, patients with DSM-IV bipolar disorder and substance dependence (N = 45) were recruited in sequential blocks to receive either group therapy (N = 21) or 6 monthly assessments, but no experimental treatment (N = 24).
  
  
  RESULTS
  When compared with patients who did not receive group therapy, patients who received IGT had significantly better outcomes on the Addiction Severity Index drug composite score (p < .03), percentage of months abstinent (p < .01), and likelihood of achieving 2 (p < .002) or 3 (p < .004) consecutive abstinent months.
  
  
  CONCLUSIONS
  IGT is a promising treatment for patients with bipolar disorder and substance dependence, who have traditionally had poor outcomes. It is unclear, however, how much of the improvement among the group therapy patients is attributable to the specific content of the treatment. A study comparing this treatment with another active psychotherapy treatment is warranted.
authors.affiliation: Alcohol and Drug Abuse Program, McLean Hospital, Belmont, Mass 02478, USA. weissr@mcleanpo.mclean.org
authors.forename: R D
authors.initials: RD
authors.lastname: Weiss
authors.forename: M L
authors.initials: ML
authors.lastname: Griffin
authors.forename: S F
authors.initials: SF
authors.lastname: Greenfield
authors.forename: L M
authors.initials: LM
authors.lastname: Najavits
authors.forename: D
authors.initials: D
authors.lastname: Wyner
authors.forename: J A
authors.initials: JA
authors.lastname: Soto
authors.forename: J A
authors.initials: JA
authors.lastname: Hennen
mesh_terms: D000328:Adult; D017677:Age Distribution; D001714:Bipolar Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D015331:Cohort Studies; D015897:Comorbidity; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008370:Manuals as Topic; D010865:Pilot Projects; D011615:Psychotherapy, Group / Q000379:methods*; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D016896:Treatment Outcome