title: Synthesis of trans-2-(1-aryl-1-methylethyl)cyclohexylamines.
abstract: As a first example of opening a secondary aziridine with a tertiary carbanion, the title amines (3a-c, aryl = phenyl, 4-tert-butylphenyl,2-naphthyl) were synthesized by opening N-(diphenylphosphinoyl)-7-azabicyclo[4.1.0]heptane, aziridine 1, with the corresponding alpha-potassium isopropylarenes, followed by a hydrolysis of the resulting phosphinamides 2a-c.
authors.affiliation: Department of Chemistry, University of Texas at El Paso 79968, USA.
authors.forename: W Y
authors.initials: WY
authors.lastname: Lee
authors.forename: J M
authors.initials: JM
authors.lastname: Salvador
authors.forename: K
authors.initials: K
authors.lastname: Bodige
mesh_terms: D003514:Cyclohexylamines / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013237:Stereoisomerism
chemical_list: D003514:Cyclohexylamines