A catalytic enantioselective total synthesis of (-)-wodeshiol.
[formula: see text] (-)-Wodeshiol of > 99% ee has been synthesized from the alpha,beta-enone shown using a number of noteworthy steps including a novel C-C coupling reaction.
Han
X
X
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Corey
E J
EJ
D002850:Chromatography, Gel; D005663:Furans; D006863:Hydrogen-Ion Concentration; D017705:Lignans / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D014961:X-Ray Diffraction
D005663:Furans; D017705:Lignans; C410704:wodeshiol