PaaSiCats: novel polyamino acid catalysts.
The abilities of five polyamino acids (Paa's) to catalyse the asymmetric epoxidation of enones 1-7 under three sets of reaction conditions were compared: polyneo-pentylglycine and polyleucine showed distinct advantages in most circumstances. All five polymers were adsorbed onto silica and from this further study, immobilised polyneo-pentylglycine (PLNSi) and polyleucine (PLLSi) were shown to be the catalysts of choice for the asymmetric epoxidation of less-reactive alpha,beta-unsaturated ketones.
Dhanda
A
A
Department of Chemistry, Liverpool University, Liverpool, UK.
Drauz
K H
KH
Geller
T
T
Roberts
S M
SM
D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D002621:Chemistry / Q000379:methods; D007659:Ketones / Q000737:chemistry; D008956:Models, Chemical; D010100:Oxygen / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry
D000596:Amino Acids; D007659:Ketones; D010455:Peptides; C027819:polyleucine; C011080:polyglycine; D012822:Silicon Dioxide; D010100:Oxygen