Synthesis of the Bycroft-Gowland structure of micrococcin P1.
[formula: see text] We describe the chemical synthesis of the accepted structure of micrococcin P1, a member of the thiostrepton group of antibiotics, and we show that this architecture does not correspond to that of the natural product. Methods developed during the present study should greatly facilitate ongoing efforts centering on the determination of the actual structure of microccin P1, in addition to being applicable to the synthesis of more complex thiostrepton congeners.
Ciufolini
M A
MA
Department of Chemistry, Rice University, Houston, Texas 77005-1892, USA. ciufi@cpe.fr
Shen
Y C
YC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D001430:Bacteriocins; D006868:Hydrolysis; D010455:Peptides; D013302:Streptomyces / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001430:Bacteriocins; D010455:Peptides; C009779:micrococcin