[YKL 40: marker of disease activity in rheumatoid arthritis?].
In patients with rheumatoid arthritis the serum and synovial fluid levels of a glycoprotein called YKL 40 are correlated to the severity of disease. YKL 40 may be related to disease activity in RA; it is induced by vitamine D and is reduced by TGF b. YKL 40 has been isolated from bovine mammary secretions during non lactating period and from Human osteosarcoma cell line MG-63. Some observations on experimental and clinical studies are presented.
Morgante
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Istituto di Medicina Interna, Università degli Studi, Pisa.
Di Munno
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Morgante
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D054392:Adipokines; D000328:Adult; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D015415:Biomarkers; D001859:Bone Neoplasms / Q000378:metabolism; D001942:Breast Feeding; D002356:Cartilage / Q000378:metabolism*; D002417:Cattle; D002648:Child; D000071451:Chitinase-3-Like Protein 1; D005260:Female; D006023:Glycoproteins / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D006801:Humans; D007378:Interleukins / Q000502:physiology; D037102:Lectins; D008297:Male; D008321:Mammary Glands, Animal / Q000378:metabolism; D008875:Middle Aged; D012516:Osteosarcoma / Q000378:metabolism; D011247:Pregnancy; D013582:Synovial Fluid / Q000737:chemistry*; D016212:Transforming Growth Factor beta / Q000502:physiology; D014407:Tumor Cells, Cultured / Q000378:metabolism; D014807:Vitamin D / Q000502:physiology
D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D007378:Interleukins; D037102:Lectins; D016212:Transforming Growth Factor beta; D014807:Vitamin D