title: Epithelioid blue nevus: a rare variant of blue nevus not always associated with the Carney complex.
abstract: Epithelioid blue nevus is a rare variant of blue nevus that has been recently described in patients with Carney complex. Some of the patients with Carney complex have multiple epithelioid blue nevi and a familial history of similar lesions is often recorded. Epithelioid blue nevus consists of an intradermal melanocytic nevus composed of polygonal epithelioid cells laden with melanin. Neoplastic cells show no maturation at the base of the lesion and, in contrast with the usual stromal changes in blue nevi, epithelioid blue nevus exhibits no fibrosis of the dermis. We have studied three cases of epithelioid blue nevus in three patients with no evidence of Carney complex. The lesions were solitary and there was no family history of similar lesions. Therefore, epithelioid blue nevus is a distinctive variant of blue nevus that may also appear as a sporadic lesion and is not always associated with Carney complex.
authors.affiliation: Department of Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Moreno
authors.forename: L
authors.initials: L
authors.lastname: Requena
authors.forename: H
authors.initials: H
authors.lastname: Kutzner
authors.forename: A
authors.initials: A
authors.lastname: de la Cruz
authors.forename: G
authors.initials: G
authors.lastname: Jaqueti
authors.forename: E S
authors.initials: ES
authors.lastname: Yus
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D058965:MART-1 Antigen; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009386:Neoplastic Syndromes, Hereditary / Q000150:complications / Q000473:pathology*; D018329:Nevus, Blue / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D018332:Nevus, Epithelioid and Spindle Cell / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D009363:Neoplasm Proteins