[Oxidation of low density lipoproteins in the presence of silica gel treated with fullerene].
This study estimated the effects of low density lipoprotein (LDL) oxidation in the presence of fullerene silicagel in comparison with ions of Cu+2 in the wide region of oxidation times and reagent concentrations. Investigation is directed to reveal the reagent parameters, that promote to increase the oxidation rate of the LDL solution. It revealed only qualitative coincidence of the LDL oxidation kinetics in the presence as Cu+2 as fullerene, that indicated on the identity of the oxidation mechanism in both cases. At the same time the revealed quantitative difference between the oxidation process parameters are interpreted in the terms of oxidation potential and the electron affinity that characterize the reagent activity in the reaction accompanied by the electron transfer. The good correlation between above mentioned parameters and the oxidation rate of the aqueous LDL solution is observed: its increasing takes place at the increase of the electron affinity or at the decrease of the oxidation potential.
Sedov
V M
VM
I. P. Pavlov St. Peterburg State Medical University, Russia.
Podosenova
N G
NG
Kuznetsov
A S
AS
Dumpis
Ia Iu
IaIu
D002244:Carbon / Q000737:chemistry*; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000737:chemistry*; D010084:Oxidation-Reduction; D058428:Silica Gel; D012822:Silicon Dioxide
D008077:Lipoproteins, LDL; D058428:Silica Gel; D002244:Carbon; D012822:Silicon Dioxide