title: Cytosolic drug delivery using pH- and light-sensitive liposomes.
abstract: A growing body of literature describes the development and applications of novel targeting and/or contents release triggering schemes to improve the therapeutic index of drugs encapsulated within liposomes. This review focuses on literature appearing between January 1995-December 1997 that report 1) antibody and receptor-mediated targeting approaches for improving drug localization and 2) acid, enzymatic, thermal or photochemical triggering processes that destabilize membranes and improve drug bioavailability via cytoplasmic delivery of liposomal contents.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN, USA
authors.initials: OV
authors.lastname: Gerasimov
authors.initials: JA
authors.lastname: Boomer
authors.initials: MM
authors.lastname: Qualls
authors.initials: DH
authors.lastname: Thompson