Synthesis of periphery-functionalized dendritic molecules using polylithiated dendrimers as starting material
A general method for the functionalization of Si-Cl terminated carbosilane dendritic molecules via organolithium or organomagnesium reagents is described. Quantitative exchange of the bromine atoms of 4-bromophenyl-functionalized dendrimers affords polylithiated species that are valuable starting materials for further functionalization, e.g., into pyridyl alcohols. The latter were successfully applied as catalyst precursors in a ruthenium-mediated ring-closure metathesis reaction.
Wijkens
P
Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, and Ciba Specialty Chemicals, Building K-420, CH-4002 Basel, Switzerland.
Jastrzebski
JT
van Der Schaaf PA
Kolly
R
Hafner
A
van Koten G