Zirconium-mediated asymmetric baeyer-villiger oxidation.
Combinations of axially chiral C2-symmetric diols were used as ligands in zirconium-mediated Baeyer-Villiger reactions. The in situ preformed Zr-diol species proved effective in the asymmetric oxidation of bicyclic and monosubstituted cyclobutanones when a hydroperoxide was employed as oxidant. Asymmetric induction could be preserved upon replacement of one out of two enantiopure BINOL ligands by conformationally flexible 2,2'-biphenol.
Bolm
C
C
Institut fur Organische Chemie der RWTH Aachen, Aachen, Germany. Carsten.Bolm@oc.rwth-aachen.de
Beckmann
O
O