Ischaemic preconditioning of the vasculature: an overlooked phenomenon for protecting the heart?
Exposing the heart to brief episodes of ischaemia protects the myocardium and vascular endothelial cells against functional damage and cell death caused by subsequent prolonged ischaemia. Elucidation of the mechanisms that are involved in this phenomenon known as 'ischaemic preconditioning' and identification of drugs that mimic the protective response have the potential to improve the prognosis of myocardial infarction and other cardiac syndromes dramatically. This article focuses on recent findings on the effects of ischaemic preconditioning of the coronary vasculature, which highlight the endothelium as an important target for a successful therapeutic approach to myocardial ischaemia-reperfusion injury.
Rubino
A
A
The Hatter Institute for Cardiovascular Studies, University College Hospital, Grafton Way, London, UK WC1E 6DB. a.rubino@ucl.ac.uk
Yellon
D M
DM
D000818:Animals; D003326:Coronary Circulation / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology