[The heme oxygenase system and its physiopathology].
The HENE-OX system (isoforms 1, 2 and 3) is the key enzyme in the oxygen dependent HEME catabolism pathway and cleavage to HEME into biliverdin IX alfa, iron and carbon-monoxide (CO). The biliverdin reductase catalyzes biliverdin into bilirubin unconjugated what is converted in bilirubin conjugated, mono and biglucuronized for the activity of hepatic Uridindifosfo-glucuronil-transferase (UDFGT). The hyperbilirubinemias unconjugated can produce kernicterus. This should be treated with metalloporphyrins (Zn-Proto IX, Zn-Mesoporphyrin, Sn-Proto-IX, Sn-Mesoporphyrin). Relations between HEM-OX/CO and NOS/NO systems. The induction of the HEME-OX system is a protective cellular mechanism against oxidative damage. Studies about the relations of the HEME-OX system with functions of various tissues (liver, kidney, cardiovascular and respiratory and hematological system, etc.).
Schüller Pérez
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D001664:Biliverdine / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D006419:Heme Oxygenase (Decyclizing) / Q000502:physiology*; D006801:Humans; D006932:Hyperbilirubinemia / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D011164:Porphyrias / Q000378:metabolism
D006418:Heme; D002248:Carbon Monoxide; D007501:Iron; D006419:Heme Oxygenase (Decyclizing); D001664:Biliverdine