title: A model to explain the difference between changes in refraction and central ocular surface power after laser in situ keratomileusis.
abstract: OBJECTIVE
  After refractive surgery, changes in central ocular surface power are usually less than actual changes in refraction. The aim of this paper was to examine the theoretical changes in the radius of the epithelial-stromal interface and corneal stromal refractive index which could take place to account for some of the empirical findings.
  
  
  METHODS
  The parameters of an aspheric human eye model featuring gradient index optics was modified using data from a clinical study evaluating effects of laser in situ keratomileusis (LASIK) for correction of moderate to high myopia. Computations were performed to determine: 1) theoretical postoperative radius of the epithelial-stromal interface and hence distribution of epithelial thickness, and 2) refractive index of the stroma when the epithelium was of fixed uniform thickness.
  
  
  RESULTS
  Within the central 2-mm diameter refractive zone of the cornea after LASIK for myopia, either of two factors could account for the difference between changes in central ocular surface power and the actual change in ocular refraction: 1) a steepening of the epithelial-stromal interface resulting from a 400% centrifugal increase in epithelial thickness, or 2) a reduction in stromal refractive index from an average of 1.376 to 1.364.
  
  
  CONCLUSIONS
  The difference between the observed changes in refraction and central ocular surface power could be explained by reduction in stromal refractive index and this could be secondary to a 6.5% increase in water content of the stroma during the postoperative period. The epithelial-stromal interface after LASIK is unlikely to steepen by the extent predicted by our model. This surface is not the source of the difference between the change in refraction and change in central ocular surface power.
authors.affiliation: Refractive Surgery Section, Instituto Oftalmologico de Alicante, University Miguel Hernandez de Elche School of Medicine, Spain. Dr_SPatel@cs.com
authors.forename: S
authors.initials: S
authors.lastname: Patel
authors.forename: J L
authors.initials: JL
authors.lastname: Alio
authors.forename: J J
authors.initials: JJ
authors.lastname: Perez-Santonja
mesh_terms: D003319:Corneal Stroma / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery; D019573:Epithelium, Corneal / Q000033:anatomy & histology / Q000502:physiology* / Q000601:surgery; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D008954:Models, Biological; D009216:Myopia / Q000503:physiopathology* / Q000601:surgery; D012029:Refraction, Ocular / Q000502:physiology*; D012031:Refractometry