Improved bioavailability of vitamin E with a self emulsifying formulation.
A single dose study was conducted to evaluate the bioavailability of a novel self-emulsifying vitamin E preparation, in comparison with that of a commercial product, Natopherol, available as soft gelatin capsules under fasted condition. The self-emulsifying preparation achieved a faster rate and higher extent of absorption. A statistically significant difference was observed between the values of the two preparations in the parameters AUC, Cmax and Tmax. Moreover, the 90% confidence interval of the logarithmic transformed AUC values of the self-emulsifying preparation over those of the soft gelatin capsule product was found to be between 2.1 and 4.1, suggesting an increase in bioavailability of between 210 and 410%. As for Cmax, the 90% confidence interval was between 2.1 and 3.0. However, no statistically significant difference was observed between the t(1/2) values estimated from the plasma concentration versus time data of the two preparations. The values are also comparable to those reported in the literature.
Julianto
T
T
Department of Pharmaceutics, School of Pharmaceutical Sciences, University of Science Malaysia, Penang.
Yuen
K H
KH
Noor
A M
AM
D000328:Adult; D019540:Area Under Curve; D001682:Biological Availability; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D004655:Emulsions; D005780:Gelatin; D006801:Humans; D008297:Male; D014810:Vitamin E / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
D002214:Capsules; D004655:Emulsions; D014810:Vitamin E; D005780:Gelatin