Synthesis of FF-MAS from lithocholic acid.
An effective synthesis of 4,4 dimethyl-cholest-8,14,24-trien-3beta-ol (FF-MAS) from lithocholic acid is described, utilising a double oxidation and regioselective Wittig reaction as key steps.
Murray
A
A
Novo Nordisk A/S, Målov, Denmark.
Grønvald
F C
FC
Nielsen
J K
JK
Faarup
P
P
D001671:Biochemistry / Q000379:methods; D002775:Cholestadienols / Q000138:chemical synthesis*; D008095:Lithocholic Acid / Q000737:chemistry
C114832:4,4-dimethyl-5alpha-cholest-8,14,24-trien-3-ol; D002775:Cholestadienols; D008095:Lithocholic Acid