Cytogenetic features of leukaemias diagnosed in residents of areas contaminated after the Chernobyl nuclear accident.
A comparison of chromosomal abnormalities in bone marrow leukaemic cells and of stable and unstable aberrations in lymphocytes of patients with hematological malignancies who live in areas with or without contamination by the Chernobyl nuclear accident has been made using FISH and G-banding. Healthy residents of these areas comprised the control group. No systematic cytogenetic differences of leukaemic cells between patients from contaminated and uncontaminated areas were observed. Lymphocyte aberrations, however, were generally higher in all subjects from contaminated areas. Comparison has been made with specific cytogenetic features of leukaemic cells and a high level of stable aberrations in lymphocytes of patients with secondary leukaemias that had developed after chemo- and/or radio-therapy.
Domrachev
E V
EV
Karyology Laboratory, National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow. dom@blood.ru
Aseeva
E A
EA
Obukhova
T N
TN
Kobzev
Y N
YN
Olshanskaya
Y V
YV
D'achenko
L V
LV
Udovichenko
A I
AI
Zakharova
A V
AV
Milyutina
G I
GI
Nechai
V V
VV
Vorobiov
A I
AI
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D003582:Cytogenetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007953:Leukemia, Radiation-Induced / Q000209:etiology* / Q000235:genetics*; D008214:Lymphocytes / Q000528:radiation effects / Q000648:ultrastructure; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000235:genetics; D018788:Radioactive Hazard Release; D014455:Ukraine