title: T-cell lineage acute lymphoblastic leukemia with chromosome 5 abnormality in a patient with Crohn's disease and lipoid nephrosis.
abstract: We describe a 17-year-old patient with a documented history of Crohn's disease (CD) and of minimal-change nephrotic syndrome (MCNS) in whom a diagnosis of T-cell acute lymphoblastic leukemia (ALL) was made. The diagnosis of ALL was established by morphological examination of bone-marrow aspirates and confirmed by means of immunophenotypic analysis showing the involvement of T-cell lineage leukemic cells. The lymphoid clone showed a karyotypic abnormality involving the long arm of chromosome 5 in a translocation (5;6). Few cases of CD complicated by ALL have been previously reported. The present one is the first case combining CD and ALL in a patient with a past history of MCNS. This raises the possibility of a relationship among those diseases. The possible mechanisms for such a relationship are discussed here.
authors.affiliation: Service d'Anesthesie et de Réanimation, Hôpital Edouard Herriot, Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Pérard
authors.forename: X
authors.initials: X
authors.lastname: Thomas
authors.forename: H
authors.initials: H
authors.lastname: Jaumain
authors.forename: G
authors.initials: G
authors.lastname: Theuil
authors.forename: M
authors.initials: M
authors.lastname: Bret
authors.forename: B
authors.initials: B
authors.lastname: Coronel
authors.forename: C
authors.initials: C
authors.lastname: Charrin
authors.forename: P
authors.initials: P
authors.lastname: Boulétreau
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002895:Chromosomes, Human, Pair 5; D003424:Crohn Disease / Q000150:complications* / Q000235:genetics*; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000150:complications* / Q000235:genetics*; D008297:Male; D009402:Nephrosis, Lipoid / Q000150:complications* / Q000235:genetics*