title: Short step enantioselective synthesis of (-)-swainsonine.
abstract: Recent discovery of asymmetric desymmetrization of meso-heterocycles using (R,R)-(salen)manganese complex 2 as a catalyst allowed easy access to optically active 2,3,4-trisubstituted pyrrolidines. Taking advantage of this new reaction, we could achieve the short-step synthesis of (-)-swainsonine 1.
authors.affiliation: Department of Molecular Chemistry, Graduate School of Science, Kyushu University, Fukuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Punniyamurthy
authors.forename: R
authors.initials: R
authors.lastname: Irie
authors.forename: T
authors.initials: T
authors.lastname: Katsuki
mesh_terms: D000470:Alkaloids; D002384:Catalysis; D002621:Chemistry / Q000379:methods; D008956:Models, Chemical; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry; D013237:Stereoisomerism; D017026:Swainsonine / Q000138:chemical synthesis*
chemical_list: D000470:Alkaloids; D011759:Pyrrolidines; D017026:Swainsonine