title: Tyrosine hydroxylase and aromatic L-amino acid decarboxylase do not coexist in neurons in the human anterior cingulate cortex.
abstract: Immunoreactivity for aromatic L-amino acid decarboxylase (AADC), the second step dopamine-synthesizing enzyme, was found immunohistochemically in neurons of the human anterior cingulate cortex (ACC). Most of these neurons were located in layers V and VI and subcortical white matter; a small number were occasionally found in layer III. Double immunohistochemistry for tyrosine hydroxylase (TH: the first step dopamine-synthesizing enzyme) and AADC revealed that no neuronal cell bodies in the ACC were doubly immunostained for TH and AADC, suggesting that these TH-only- or AADC-only-immunoreactive neurons were not dopaminergic. AADC neurons in the human ACC might transform L-DOPA to dopamine, droxidopa to noradrenaline, and/or 5-hydroxytryptophan to serotonin.
authors.affiliation: Department of Anatomy, Fujita Heath University, School of Medicine, Toyoake, Japan. kikemoto@fujita-hu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Ikemoto
authors.forename: K
authors.initials: K
authors.lastname: Kitahama
authors.forename: A
authors.initials: A
authors.lastname: Nishimura
authors.forename: A
authors.initials: A
authors.lastname: Jouvet
authors.forename: K
authors.initials: K
authors.lastname: Nishi
authors.forename: R
authors.initials: R
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Jouvet
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
mesh_terms: D000328:Adult; D000368:Aged; D001142:Aromatic-L-Amino-Acid Decarboxylases / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism*
chemical_list: D014446:Tyrosine 3-Monooxygenase; D001142:Aromatic-L-Amino-Acid Decarboxylases