Rapid tumor necrosis induced by electrochemotherapy with intratumoral injection of bleomycin in a hamster tongue cancer model.
This study evaluated the effects of electrochemotherapy (ECT) with intratumoral injection of bleomycin (BLM) on the chemically induced tongue cancer model in the hamster. Intratumoral injection of BLM followed by high-voltage electrical treatment induced rapid necrosis of the tumor within 48 hours and subsequent rapid tumor volume reduction. Three weeks after the ECT with BLM, 3 of the 6 animals showed no palpable tumor, while no antitumor effects were observed in the control groups. Because of the remarkable antitumor effect with no major observed side effects, we concluded that ECT combined with intratumoral injection of BLM has the potential to enhance treatment results for tongue cancer.
Omura
S
S
Department of Oral and Maxillofacial Surgery, Yokohama City University School of Medicine, Japan. sos3728@med.yokohama-cu.ac.jp
Tsuyuki
Y
Y
Ohta
S
S
Li
X
X
Bukawa
H
H
Fujita
K
K
D000704:Analysis of Variance; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D001761:Bleomycin / Q000008:administration & dosage*; D006224:Cricetinae; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D018274:Electroporation; D015552:Injections, Intralesional; D008297:Male; D008647:Mesocricetus; D009336:Necrosis; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D018709:Statistics, Nonparametric; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000964:Antimetabolites, Antineoplastic; D001761:Bleomycin