title: Immune response to surface protein A of Streptococcus pneumoniae and to high-molecular-weight outer membrane protein A of Moraxella catarrhalis in children with acute otitis media.
abstract: The immune response was evaluated in 11 children with Streptococcus pneumoniae and in 9 children with Moraxella catarrhalis otitis media. The age of the children had a range of 4-32 months. The mean IgG, IgM, and IgA antibody responses to surface protein A (PspA) of S. pneumoniae in sera from children at the acute and convalescent stages were 4864 versus 5831 ng/mL, P<.05, 1075 versus 3752 ng/mL, P<.05, and 67 versus 93 ng/mL, nonsignificant (NS), respectively. The mean IgG, IgM, and IgA antibody responses to the high-molecular-weight outer membrane protein (UspA) of M. catarrhalis in sera from children at acute and convalescent stages were 710 versus 935 mg/mL, NS; 1895 versus 2646 ng/mL, NS; and 121 versus 204 ng/mL, P<.05, respectively. These data show that PspA and UspA are immunogenic in children after otitis media.
authors.affiliation: Wakayama Medical College, Wakayama, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Samukawa
authors.forename: N
authors.initials: N
authors.lastname: Yamanaka
authors.forename: S
authors.initials: S
authors.lastname: Hollingshead
authors.forename: T F
authors.initials: TF
authors.lastname: Murphy
authors.forename: H
authors.initials: H
authors.lastname: Faden
mesh_terms: D000208:Acute Disease; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology*; D002675:Child, Preschool; D003289:Convalescence; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008297:Male; D008970:Molecular Weight; D001936:Moraxella catarrhalis / Q000276:immunology*; D016870:Neisseriaceae Infections / Q000097:blood / Q000276:immunology*; D010033:Otitis Media / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000097:blood / Q000276:immunology*; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C051592:pneumococcal surface protein A; C078167:OMPA outer membrane proteins