title: Physical and psychosocial correlates of hormone replacement therapy with chronically stressed postmenopausal women.
abstract: OBJECTIVE
  This study investigated the relationship between hormone replacement therapy (HRT) use and physical and psychosocial functioning in a sample of chronically stressed older women.
  
  
  METHODS
  Participants (N = 94) were postmenopausal women caring for a parent or spouse with dementia.  Caregivers were evaluated using both psychological and physical health indices.
  
  
  RESULTS
  Caregivers receiving HRT reported lower levels of hostility and were less likely to report unpleasant interactions with members of their support network; these findings were unrelated to demographic variables, caregiving-related indices, or health behaviors.  HRT recipients had lower 10-year risk scores for cardiovascular disease, but there were no group differences in stroke risk.  The largest effects on hostility, depression, heart and stroke risk were observed in caregivers receiving a combination of estradiol and progesterone.
  
  
  CONCLUSIONS
  HRT for postmenopausal women may promote positive outcomes for some, but not for all, affective states and cardiovascular variables vulnerable to chronic life stressors.
authors.affiliation: University of Missouri, St. Louis, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Steffen
authors.forename: L W
authors.initials: LW
authors.lastname: Thompson
authors.forename: D
authors.initials: D
authors.lastname: Gallagher-Thompson
authors.forename: D
authors.initials: D
authors.lastname: Koin
mesh_terms: D000368:Aged; D017028:Caregivers / Q000523:psychology*; D002561:Cerebrovascular Disorders / Q000209:etiology; D003704:Dementia / Q000451:nursing; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy / Q000523:psychology*; D005260:Female; D006304:Health Status; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D012307:Risk Factors; D012944:Social Support; D013315:Stress, Psychological / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D004958:Estradiol