Can retinoic acid ameliorate the physiologic and morphologic effects of elastase instillation in the rat?
Tepper
J
J
Genentech, Inc, South San Francisco, CA 94080, USA.
Pfeiffer
J
J
Aldrich
M
M
Tumas
D
D
Kern
J
J
Hoffman
E
E
McLennan
G
G
Hyde
D
D
D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D007322:Instillation, Drug; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D010196:Pancreatic Elastase / Q000008:administration & dosage / Q000633:toxicity*; D011650:Pulmonary Alveoli / Q000187:drug effects* / Q000503:physiopathology; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed; D014132:Trachea; D016896:Treatment Outcome; D014212:Tretinoin / Q000627:therapeutic use*
D007641:Keratolytic Agents; D014212:Tretinoin; D010196:Pancreatic Elastase