title: Influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on the synthesis of phosphorothioate oligonucleotides.
abstract: Extensive investigations on the influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on stereo-reproducibility of solid phase synthesis of phosphorothioate oligodeoxyribonucleotides via the phosphoramidite approach indicate that the process is stereoreproducible and under inherent process control.
authors.affiliation: Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
authors.forename: Z S
authors.initials: ZS
authors.lastname: Cheruvallath
authors.forename: H
authors.initials: H
authors.lastname: Sasmor
authors.forename: D L
authors.initials: DL
authors.lastname: Cole
authors.forename: V T
authors.initials: VT
authors.lastname: Ravikumar
mesh_terms: D002851:Chromatography, High Pressure Liquid; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D013237:Stereoisomerism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D016376:Oligonucleotides, Antisense; D013873:Thionucleotides