[The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver].
Experiments on rats with heliotrine-induced acute liver damage showed the main parameters of biochemical detoxication to be inhibited. Treatment of the test animals with perftoran increased the initially low level of microsomal hemoproteins, the activity of enzymes participating at the second stage of biotransformation, the content of reduced glutathione, and the activity of enzymes involved in the glutathione metabolism. Perftoran decreased the level of lipid peroxidation in the microsomal fraction of damaged hepatocytes and activated enzymes involved in the antioxidant protector system.
Inoiatov
F Sh
FSh
Second State Medical Institute, Tashkent, Uzbekistan.
D000208:Acute Disease; D000818:Animals; D001547:Benzaldehydes / Q000493:pharmacokinetics / Q000506:poisoning; D052117:Benzodioxoles; D001802:Blood Substitutes / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology; D004353:Drug Evaluation, Preclinical; D005466:Fluorocarbons / Q000627:therapeutic use*; D008658:Inactivation, Metabolic; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013997:Time Factors
D001547:Benzaldehydes; D052117:Benzodioxoles; D001802:Blood Substitutes; D005466:Fluorocarbons; C063334:perftoran; C005454:piperonal