EGF receptor signalling: the importance of presentation.
Activation of the Drosophila EGF receptor requires the transmembrane TGF-alpha-like ligand Spitz. Recent studies have shed new light on the role of two transmembrane proteins, Star and Rhomboid, in the presentation and subsequent proteolytic processing of Spitz.
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Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, 48149, Germany.
D000818:Animals; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D004815:Epidermal Growth Factor; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D000098682:Steroidogenic Acute Regulatory Protein
D029721:Drosophila Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; C081481:Rho protein, Drosophila; C472498:Stet protein, Drosophila; D000098682:Steroidogenic Acute Regulatory Protein; C076026:spi protein, Drosophila; D004815:Epidermal Growth Factor; D066246:ErbB Receptors