Application of derivative UV spectrophotometry for the determination of ciprofloxacin, norfloxacin and ofloxacin in tablets.
The first-, second-, third- and fourth-order derivative spectrophotometric methods, by using the "peak-zero" (P-0) and "peak-peak" (P-P) techniques of measurement have been developed for the determination of ciprofloxacin hydrochloride, norfloxacin and ofloxacin in tablets. The calibration curves are linear within the concentration range of 2.0-12.0 micrograms ml-1 for ciprofloxacin hydrochloride, 1.0-10.0 micrograms ml-1 for norfloxacin and 2.5-15.0 micrograms ml-1 for ofloxacin. The procedure is simple, rapid and the results are reliable.
Hopkała
H
H
Department of Medicinal Chemistry, Medical Academy, Lublin, Poland.
Kowalczuk
D
D
D000890:Anti-Infective Agents / Q000032:analysis*; D002138:Calibration; D002939:Ciprofloxacin / Q000032:analysis*; D009643:Norfloxacin / Q000032:analysis*; D015242:Ofloxacin / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000890:Anti-Infective Agents; D013607:Tablets; D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin