title: Synthesis of natural-product-based compound libraries.
abstract: Natural products cover a diversity space not yet available from synthetic libraries, with an unrivalled success rate as drug leads. The combinatorial synthesis of non-oligomeric natural-product-based libraries, however, is still limited to few examples because access to easily modified units strongly depends on the availability of a core structure either from a natural source, or through a suitable synthetic route. Only a few resourceful groups have managed the latter approach for more demanding multifunctional natural drug leads, such as epothilones.
authors.affiliation: Vrije Universiteit Amsterdam, Bioorganic Chemistry - FEW/OAC, NL-1081 HV, Amsterdam, The Netherlands. wessjohn@chem.vu.nl
authors.forename: L A
authors.initials: LA
authors.lastname: Wessjohann
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D011453:Prostaglandins / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001685:Biological Factors; D011453:Prostaglandins