Apoptosis in neural development and disease.
Cell death via apoptosis is a prominent feature in mammalian neural development. Recent studies into the basic mechanism of apoptosis have revealed biochemical pathways that control and execute apoptosis in mammalian cells. Protein factors in these pathways play important roles during development in regulating the balance between neuronal life and death. Additionally, mounting evidence indicates such pathways may also be activated during several neurodegenerative diseases, resulting in improper loss of neurons.
Nijhawan
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D
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas 75235, USA. nijhawan.deepak@tumora.swmed.edu
Honarpour
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N
Wang
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X
D000544:Alzheimer Disease / Q000503:physiopathology*; D000690:Amyotrophic Lateral Sclerosis / Q000503:physiopathology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D002843:Chromatin / Q000502:physiology; D003574:Cytochrome c Group / Q000378:metabolism; D053938:DNA Fragmentation / Q000502:physiology; D004789:Enzyme Activation; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D009420:Nervous System / Q000254:growth & development*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology
D002843:Chromatin; D003574:Cytochrome c Group; D019253:Proto-Oncogene Proteins c-bcl-2; D020169:Caspases