title: Local and systemic immune responses to combined vibrio cholerae CVD103-HgR and salmonella typhi ty21a live oral vaccines after primary immunization and reimmunization.
abstract: The local and systemic antibody responses elicited following concomitant primary immunization and reimmunization with the live oral attenuated Vibrio cholerae CVD103-HgR and Salmonella typhi Ty21a vaccine strains were determined in healthy adult volunteers. A more pronounced serum vibriocidal antibody response was generated after primary immunization compared to reimmunization 2.5 or 3.5 yr later. The seroconversion rate (> or =4-fold rise over baseline) was 81% subsequent to primary immunization versus 57% (p=0.018) and 65% (p=0.639) upon reimmunization at 2.5 and 3.5 yr, respectively. A similar trend was observed for serum anti-S. typhi lipopolysaccharide (LPS) antibodies. After primary immunization, 48% of subjects manifested a significant rise in coproantibody levels to V. cholerae LPS while 60% did so for cholera toxin (CT). Upon reimmunization, the response rate for LPS ranged from 38% at 2.5 yr to 56% at 3.5 yr (p>0.05), while that for CT varied from 31% (p=0. 007) to 50% (p=0.541) at 2.5 and 3.5 yr, respectively. The anti-S. typhi IgA coproantibody response rate was 70% subsequent to primary immunization versus 47% at 2.5 yr (p=0.021) and 63% at 3.5 yr (p=0. 77).
authors.affiliation: Institute for Specific Prophylaxis and Tropical Medicine, University of Vienna, A-1095 Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Kollaritsch
authors.forename: S J
authors.initials: SJ
authors.lastname: Cryz
authors.forename: A B
authors.initials: AB
authors.lastname: Lang
authors.forename: C
authors.initials: C
authors.lastname: Herzog
authors.forename: J U
authors.initials: JU
authors.lastname: Que
authors.forename: G
authors.initials: G
authors.lastname: Wiedermann
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology*; D022121:Cholera Vaccines / Q000276:immunology*; D005260:Female; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D012485:Salmonella typhi / Q000276:immunology*; D017778:Vaccines, Combined / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D022121:Cholera Vaccines; D007070:Immunoglobulin A; D008070:Lipopolysaccharides; D017778:Vaccines, Combined