title: Anti-platelet aggregation constituents from Gynura elliptica.
abstract: A p-hydroxyacetophenone-like derivative, (+)-gynunone, and a chromane, together with six known compounds were isolated from the CHCl3 fraction of the roots of Gynura elliptica. Their structures were determined by means of spectral analyses. Among the isolates, 6-acetyl-2,2-dimethylchroman-4-one and vanillin showed anti-platelet aggregation activity induced by arachidonic acid in vitro.
authors.affiliation: Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan.
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: I L
authors.initials: IL
authors.lastname: Tsai
authors.forename: I S
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000098:Acetophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D002839:Chromans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010938:Plant Oils / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013624:Taiwan
chemical_list: D000098:Acetophenones; D002839:Chromans; D004365:Drugs, Chinese Herbal; D010938:Plant Oils; D010975:Platelet Aggregation Inhibitors; C412185:gynunol; C412184:gynunone