title: [Sentinel node and operable breast cancer: utilization of blue dye injection. Pilot study].
abstract: OBJECTIVE
  Sentinel node detection in breast cancer can be realized with colorimetric and isotopic procedures often associated. The aim of this study was to report results obtained with blue dye injection only.
  
  
  METHODS
  From September 1998 to July 1999, blue dye injection was performed in 73 consecutive patients (mean age: 51 years, range: 36-71 years); 51/70 70% were post-menopausal and half of them were under substitute hormonal treatment; 70% of cancers were discovered through routine mammography. There were 12 bilateral cancers, six of them synchronous, and 84% of cancers were located in the external quadrants. Individualization of sentinel node was performed through blue dye injection into the tumor in case of preoperative diagnosis or in the tumoral site in case of discovery of the cancer through extemporaneous histological examination.
  
  
  RESULTS
  71 out of 73 cancers were classified pT1 and 70% measured 10 mm and over. Individualization of sentinel node failed in two obese patients. Sentinel node invasion concerned one node (n = 7), two nodes (n = 1) and three nodes (n = 1). Conservative treatment was performed in 72 patients out of 73; in case of sentinel node invasion, axillary irradiation was performed without reoperation.
  
  
  CONCLUSIONS
  Blue dye injection for sentinel node individualization is an accurate technique in selected patients in case of small tumors. Reoperation can be avoided and replaced by axillary irradiation in case of N+ tumors. Duration of hospitalization was 48 hours or under in 70/73 patients. Nevertheless isotopic procedure must be recommended as a routine technique in learning centers and for most surgical teams.
authors.affiliation: Institut Curie, Paris, France.
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
authors.forename: C
authors.initials: C
authors.lastname: Nos
authors.forename: F
authors.initials: F
authors.lastname: Lojodice
authors.forename: O
authors.initials: O
authors.lastname: Languille
authors.forename: Y
authors.initials: Y
authors.lastname: Remvikos
authors.forename: J R
authors.initials: JR
authors.lastname: Vilcoq
authors.forename: K B
authors.initials: KB
authors.lastname: Clough
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D006801:Humans; D007267:Injections; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008875:Middle Aged; D010865:Pilot Projects; D012680:Sensitivity and Specificity
chemical_list: D004396:Coloring Agents