title: Recent developments in tritium incorporation for radiotracer studies.
abstract: The essential nature of rapid radiotracer synthesis very early in drug discovery programs has driven the need for better and more varied tritium incorporation methods. This review presents a summary of recent advances for tritium introduction via tritiated water, tritium gas, complex tritides, and a range of recently improved tritiation reagents. Access to a wider range of tritiated reagents (for tritioacetylation, tritioformylation, methylation, etc.) and commercial manifolds for the transfer and use of tritium gas is also discussed.
authors.affiliation: The National Tritium Labelling Facility, Physical Biosciences Division, Mailstop 75-123, E.O. Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA.
authors.forename: M
authors.initials: M
authors.lastname: Saljoughian
authors.forename: P G
authors.initials: PG
authors.lastname: Williams
mesh_terms: D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000494:pharmacology; D014316:Tritium / Q000737:chemistry*
chemical_list: D019275:Radiopharmaceuticals; D014316:Tritium