title: [Validation of a method to inactivate fentanyl in the used devices of Durogesic].
abstract: A recent literature study has shown that after 3 days of use of a transdermic patch of fentanyl (Durogésic(R)), there was such an amount of drug remaining that may make its excessive use possible. First of all, we have developed a fentanyl assay by a spectrophotometric method and then, the remaining amount of fentanyl was determined in 29 used patches. This study has shown that a mean of 22% of fentanyl remained in the used patches, each original content astounded. Then, we have determined an easy and feasible method in a chemist's shop allowing inactivation of fentanyl in the used patches and so preventing its diversion.
authors.affiliation: Faculté de Pharmacie, 5, rue Albert Lebrun, F 54000 Nancy Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Zambaux
authors.forename: F
authors.initials: F
authors.lastname: Bonneaux
authors.forename: H
authors.initials: H
authors.lastname: Du
authors.forename: P
authors.initials: P
authors.lastname: Labrude
mesh_terms: D000279:Administration, Cutaneous; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000032:analysis*; D005283:Fentanyl / Q000008:administration & dosage / Q000032:analysis*; D019966:Substance-Related Disorders / Q000517:prevention & control
chemical_list: D000701:Analgesics, Opioid; D005283:Fentanyl