title: Left-right axis malformations in man and mouse.
abstract: The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, 77030, USA. bcasey@bcm.tmc.edu
authors.forename: B
authors.initials: B
authors.lastname: Casey
authors.forename: B P
authors.initials: BP
authors.lastname: Hackett
mesh_terms: D000818:Animals; D004627:Embryonic Induction; D005346:Fibroblast Growth Factors / Q000502:physiology; D005801:Genes, Homeobox; D053823:Hedgehog Proteins; D006801:Humans; D051379:Mice; D011506:Proteins / Q000502:physiology; D012857:Situs Inversus / Q000235:genetics*; D015534:Trans-Activators; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D053823:Hedgehog Proteins; D011506:Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors