An enhanced process for encapsulating aspirin in ethyl cellulose microcapsules by solvent evaporation in an O/W emulsion.
An enhanced process for microencapsulating aspirin in ethylcellulose was demonstrated using an oil-in-water emulsification/solvent evaporation technique. Methylene chloride (CH2Cl2) was used as the dispersed medium and water as the dispersing medium. The recovered weight, particle size distribution, aspirin loading efficiency, and the aspirin release rate of microcapsules were analysed. The addition of appropriate amounts of non-solvent (n-heptane) prior to the emulsification increases the recovered weight, but decreases the size of the formed microcapsules. The addition of non-solvent also changes the microcapsule characteristics, resulting in a coarser surface and an increased release rate. Increasing the polymer (ethylcellulose) concentration in the dispersed phase increases the size of the microcapsules, the recovered weight, and loading efficiency, but decreases the release rate. The release rate follows first-order kinetics during the first 12 h, suggesting a monolithic system with aspirin uniformly distributed in the microcapsule.
Yang
C Y
CY
Department of Chemical Engineering, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Tsay
S Y
SY
Tsiang
R C
RC
D001241:Aspirin / Q000008:administration & dosage*; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D004339:Drug Compounding; D004655:Emulsions; D008855:Microscopy, Electron, Scanning; D009821:Oils; D010316:Particle Size; D012997:Solvents; D014783:Viscosity; D014867:Water
D002214:Capsules; D004655:Emulsions; D009821:Oils; D012997:Solvents; D014867:Water; C013517:ethyl cellulose; D002482:Cellulose; D001241:Aspirin