Amperometric biosensors/sequential injection analysis system for simultaneous determination of S- and R-captopril.
Two amperometric biosensors based on L- and D-amino acid oxidase, respectively, are proposed for the simultaneous detection of S- and R-captopril in a sequential injection analysis system (SIA). The linear concentration ranges are: 0.4-1.6 micromol/l (S-captopril) and 120-950 nmol/l (R-captopril) with detection limits of 0.2 and 15 nmol/l, respectively. The biosensors/SIA system can be used reliably on-line in synthesis process control, for the simultaneous assay of S- and R-captopril with a frequency of 34 samples/h.
Stefan
R I
RI
Department of Chemistry, University of Pretoria, South Africa.
van Staden
J K
JK
Aboul-Enein
H Y
HY
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D015374:Biosensing Techniques; D002216:Captopril / Q000032:analysis*; D004563:Electrochemistry; D013237:Stereoisomerism
D000806:Angiotensin-Converting Enzyme Inhibitors; D002216:Captopril