[Comparative od adaptive response to gamma-radiation and nickel sulfate treatment in human cells].
Increased viability of human cells (line rhabdomyosarcoma) to challenge doses of NiSO4 (10(-5)-10(-3) M) was formed when cells were preirradiated with low doses of gamma-radiation (10-14 cGy). Observed adaptive response was similar to radioadaptive response in human fibroblasts, pretreated with low doses of gamma-radiation and challenge dose of the same mutagen. Pretreatment with low concentration of NiSO4 induced in human fibroblasts increased resistance of DNA to the treatment with challenge doses of gamma-radiation and stimulated DNA repair synthesis after treatment with NiSO4 and 4-nitroquinoline-1-oxide. These data confirm the existence of cross-adaptation in the experiments with NiSO4.
Perminova
E V
EV
Institute of the North Industrial Ecology Problems, Kola Science Centre, Russian, Academy of Sciences, Apatity, Murmansk region.
Sinel'shchikova
T A
TA
Perminova
I N
IN
Zasukhina
G D
GD
D000222:Adaptation, Physiological / Q000187:drug effects* / Q000528:radiation effects*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005347:Fibroblasts / Q000187:drug effects* / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D007509:Irritants / Q000494:pharmacology*; D009532:Nickel / Q000494:pharmacology*; D011829:Radiation Dosage; D014407:Tumor Cells, Cultured
D007509:Irritants; C029938:nickel sulfate; D009532:Nickel