title: An outbreak of enterically transmitted non-A, non-E viral hepatitis.
abstract: Patients with isolated serum transaminase elevations of unknown cause are common in China. An outbreak of such disease took place in a technicians' school during 1996. To define the epidemic and determine the etiology, a study was carried out, which included investigation of epidemiological, clinical and histological features. The symptoms of this disease were mild. The major clinical feature was transaminase elevation, and all serum markers of known hepatitis viruses were negative. Although the course of disease in most patients was self-limiting, in a few it was prolonged and relapsed. Histological findings were mild portal hepatitis or non-specific reactive hepatitis. The disease first appeared in 1994, and this outbreak occurred after October 1996. A total of 381 people were affected and the prevalence was as high as 60.7%. Casual contact and small-scale food transmission were considered to be risk factors for infection and the epidemic was under control 2 months later following the introduction of preventive measures for gastroenteric infection. Viral genomic fragments from the so-called transfusion-transmitted virus (TTV) were detected in acute-phase sera and stool samples collected 2 weeks before onset. Therefore, this disease outbreak might be another form of enterically transmitted viral hepatitis, not related to hepatitis A and E.
authors.affiliation: Department of Infectious Diseases, Nanfang Hospital, Guangzhou, China.
authors.forename: K X
authors.initials: KX
authors.lastname: Luo
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: S S
authors.initials: SS
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Nie
authors.forename: S C
authors.initials: SC
authors.lastname: Yang
authors.forename: D X
authors.initials: DX
authors.lastname: Liu
authors.forename: W F
authors.initials: WF
authors.lastname: Liang
authors.forename: H T
authors.initials: HT
authors.lastname: He
authors.forename: Q
authors.initials: Q
authors.lastname: Lu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D002681:China / Q000453:epidemiology; D004266:DNA Virus Infections / Q000453:epidemiology* / Q000473:pathology / Q000635:transmission / Q000821:virology; D004267:DNA Viruses / Q000302:isolation & purification; D004279:DNA, Viral / Q000097:blood; D004196:Disease Outbreaks; D005243:Feces / Q000821:virology; D006508:Hepatitis Antibodies / Q000097:blood; D016752:Hepatitis E virus / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology* / Q000473:pathology / Q000635:transmission* / Q000821:virology; D006507:Hepatovirus / Q000276:immunology; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D015995:Prevalence
chemical_list: D004279:DNA, Viral; D006508:Hepatitis Antibodies; D000410:Alanine Transaminase