title: Sarcoidosis with pulmonary fibrosis: CT patterns and correlation with pulmonary function.
abstract: OBJECTIVE
  The purpose of our study was to identify CT patterns of pulmonary fibrosis in patients with sarcoidosis and to correlate these patterns with pulmonary function tests.
  
  
  METHODS
  We conducted a retrospective review of CT scans of 80 patients with proven sarcoidosis and evidence of fibrotic changes on chest radiographs.
  
  
  RESULTS
  Three main CT patterns were identified: bronchial distortion (n = 38, 47%), mainly central; honeycombing (n = 23, 29%), mainly peripheral; and linear (n = 19, 24%), mainly diffuse. In most cases, a pattern was clearly identified as shown by the good agreement between observers (kappa = 0.87). Nodules were significantly associated with the linear (87%) and distorted (71%) patterns, but not with the honeycomb pattern (35%). The honeycomb pattern was most often associated with restriction and decreased lung diffusing capacity for carbon monoxide. Patients with bronchial distortion had lower expiratory airflow rates. The linear pattern was generally associated with the least functional impairment.
  
  
  CONCLUSIONS
  CT may be a useful tool for defining subgroups of patients with fibrotic pulmonary sarcoidosis. CT reveals three main patterns that may reflect different distributions of fibrotic lesions in the lung with different functional pulmonary impairments. The persistence of active pulmonary lesions suggested by the presence of nodular lesions was often associated with linear and distorted patterns.
authors.affiliation: Department of Radiology, Fédération MARTHA, UFR Bobigny, Université Paris, Bobigny, France.
authors.forename: M
authors.initials: M
authors.lastname: Abehsera
authors.forename: D
authors.initials: D
authors.lastname: Valeyre
authors.forename: P
authors.initials: P
authors.lastname: Grenier
authors.forename: H
authors.initials: H
authors.lastname: Jaillet
authors.forename: J P
authors.initials: JP
authors.lastname: Battesti
authors.forename: M W
authors.initials: MW
authors.lastname: Brauner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005355:Fibrosis; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed