title: Surfactant transport over airway liquid lining of nonuniform depth.
abstract: Numerous effects (e.g., airway wall buckling, gravity, airway curvature, capillary instabilities) give rise to nonuniformities in the depth of the liquid lining of peripheral lung airways. The effects of such thickness variations on the unsteady spreading of a surfactant monolayer along an airway are explored theoretically here. Flow-induced film deformations are shown to have only a modest influence on spreading rates, motivating the use of a simplified model in which the liquid-lining depth is prescribed and the monolayer concentration satisfies a spatially inhomogeneous nonlinear diffusion equation. Two generic situations are considered: spreading along a continuous annular liquid lining of nonuniform depth, and spreading along a rivulet that wets the airway wall with zero contact angle. In both cases, transverse averaging at large times yields a one-dimensional approximation of axial spreading that is valid for the majority of the monolayer. However, a localized monolayer remains persistently two dimensional in a region at its leading edge having axial length scales comparable to the length scale of transverse depth variation. It is also shown how the transverse spreading of a monolayer may be arrested as it approaches a static contact line at the edge of a rivulet. Implications for Surfactant Replacement Therapy are discussed.
authors.affiliation: Department of Applied Mathematics and Theoretical Physics, University of Cambridge, United Kingdom. O.E.Jensen@damtp.cam.ac.uk
authors.forename: H A
authors.initials: HA
authors.lastname: Williams
authors.forename: O E
authors.initials: OE
authors.lastname: Jensen
mesh_terms: D001693:Biological Transport, Active; D001698:Biomedical Engineering; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008953:Models, Anatomic; D008954:Models, Biological; D011663:Pulmonary Surfactants / Q000502:physiology*
chemical_list: D011663:Pulmonary Surfactants