title: Structure-based library design: molecular modelling merges with combinatorial chemistry.
abstract: Recent advances in both computational and experimental techniques now allow a very fruitful interplay of computational and combinatorial chemistry in the structure-based design of combinatorial libraries.
authors.affiliation: Pharmaceuticals Division, Hoffmann-La Roche Ltd, Basel, CH 4070, Switzerland. hans-joachim.boehm@roche.com
authors.forename: H J
authors.initials: HJ
authors.lastname: Böhm
authors.forename: M
authors.initials: M
authors.lastname: Stahl
mesh_terms: D020650:Combinatorial Chemistry Techniques; D008024:Ligands; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D008024:Ligands