title: Reduction in human immunodeficiency virus type 1 mutations associated with drug resistance after initiating new therapeutic regimens in pretreated patients.
abstract: The objective of this study was to investigate the effect of initiating a salvage-therapy regimen on resistant viruses in heavily treated patients infected with human immunodeficiency virus type 1 (HIV-1). Nineteen patients receiving multiple antiretroviral drugs were tested for HIV-1 mutations associated with drug resistance by using an in-house method at baseline and at weeks 2, 4, and 8 of the salvage-therapy regimen. For the majority of mutations analyzed, the mean number of detectable mutations at baseline was significantly higher than the mean at weeks 2, 4, and 8 of salvage therapy. Introducing new and more potent therapy reduces the number of detectable drug resistance-associated mutations within 8 weeks, and no evidence was found that the new therapy promoted the emergence of novel mutations.
authors.affiliation: MediTech Media, Ltd., London WC1V 6QA, United Kingdom. HelenD@meditech.co.uk.
authors.forename: H L
authors.initials: HL
authors.lastname: Devereux
authors.forename: C
authors.initials: C
authors.lastname: Loveday
authors.forename: M
authors.initials: M
authors.lastname: Youle
authors.forename: C A
authors.initials: CA
authors.lastname: Sabin
authors.forename: A
authors.initials: A
authors.lastname: Burke
authors.forename: M A
authors.initials: MA
authors.lastname: Johnson
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy* / Q000382:microbiology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D009154:Mutation; D016133:Polymerase Chain Reaction; D016879:Salvage Therapy; D013997:Time Factors
chemical_list: D019380:Anti-HIV Agents