title: Playing second fiddle: second-strand processing and liberation of transposable elements from donor DNA.
abstract: Retroviruses and many transposons of both prokaryotes and eukaryotes share similar chemical reactions in their transposition. Some elements remain attached to donor DNA during transposition and their translocation results in a fusion between target and donor replicons. However, many elements are separated from their flanking donor DNA prior to their insertion into a target site, which requires processing of both strands at both ends of the element. A variety of strategies have been adopted for cleavage of the second, complementary strand to liberate the transposon.
authors.affiliation: Laboratoire de Microbiologie et Génétique Moléculaires, CNRS UPR9007, 118 Rte de Narbonne, F31062 Toulouse Cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Turlan
authors.forename: M
authors.initials: M
authors.lastname: Chandler
mesh_terms: D000818:Animals; D004251:DNA Transposable Elements / Q000502:physiology*; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000502:physiology; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D019426:Integrases / Q000502:physiology; D011387:Prokaryotic Cells / Q000378:metabolism; D011995:Recombination, Genetic; D012190:Retroviridae / Q000201:enzymology / Q000235:genetics; D014158:Transcription, Genetic; D019895:Transposases / Q000502:physiology
chemical_list: D004251:DNA Transposable Elements; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; C111652:mariner transposases; D019426:Integrases; D019895:Transposases