Post-axial limb defects with maternal sodium valproate exposure.
A male child is described with bilateral talipes equinovarus, absent fibulae with bowing and shortening of the tibiae and facial dysmorphic features. His mother was on a daily dose of 2000 mg sodium valproate for convulsions. This case raises the possibility that postaxial limb defects might be caused by intrauterine valproate exposure.
Pandya
N A
NA
Jani
B R
BR
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007223:Infant; D017880:Limb Deformities, Congenital / Q000139:chemically induced*; D008297:Male; D011247:Pregnancy; D014635:Valproic Acid / Q000009:adverse effects*
D000927:Anticonvulsants; D014635:Valproic Acid