title: Effects of partial liquid ventilation with perfluorodecalin in the juvenile rabbit lung after saline injury.
abstract: OBJECTIVE
  To evaluate the feasibility of using the perfluorochemical, perfluorodecalin, for partial liquid ventilation (PLV) with respect to gas exchange and lung mechanics in normal and saline-injured lungs of juvenile rabbits.
  
  
  METHODS
  Experimental, prospective, randomized, controlled study.
  
  
  METHODS
  Physiology laboratory at a university medical school.
  
  
  METHODS
  Seventeen juvenile rabbits assigned to three groups.
  
  
  METHODS
  The conventional mechanical ventilation (CMV)-injury group (n = 5) was treated with CMV after establishing a lung injury; the PLV-injury group (n = 6) was treated with PLV after lung injury; and the PLV-healthy group (n = 6) was supported with PLV without lung injury. Lung injury was created by repeated saline lung lavages. PLV-treated animals received a single dose of intratracheal perfluorodecalin at a volume equal to the measured preinjury gas functional residual capacity (functional residual capacity = 18.6+/-1.5 [SEM] mL/kg).
  
  
  RESULTS
  Sequential measurements of total respiratory compliance and arterial blood chemistries were performed in all groups. Oxygenation index (OI) and ventilation efficiency index were calculated. After lung injury, there was a significant (p < .05) decrease in PaO2, total respiratory compliance, and ventilation efficiency index and an increase in OI and PaCO2. In the PLV-injury group, PLV significantly (p < .05) improved PaO2 (+60%) and OI (-33%) over time. Compliance was significantly (p < .05) higher (90%) than in the CMV-injury group over time.
  
  
  CONCLUSIONS
  These results demonstrate that PLV with perfluorodecalin improved oxygenation and increased respiratory compliance in the saline-injured rabbit lung. In addition, similar to the effects of several other perfluorochemical liquids on normal lungs, pulmonary administration of perfluorodecalin was associated with a small impairment in gas exchange and a significant decrease in lung compliance in the juvenile rabbit model.
authors.affiliation: Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Al-Rahmani
authors.forename: K
authors.initials: K
authors.lastname: Awad
authors.forename: T F
authors.initials: TF
authors.lastname: Miller
authors.forename: M R
authors.initials: MR
authors.lastname: Wolfson
authors.forename: T H
authors.initials: TH
authors.lastname: Shaffer
mesh_terms: D000818:Animals; D005466:Fluorocarbons; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology; D010952:Plasma Substitutes; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D011817:Rabbits; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000502:physiology*
chemical_list: D005466:Fluorocarbons; D010952:Plasma Substitutes; C008805:perfluorodecalin