Sequence analysis of the Rhop-3 gene of Plasmodium yoelii.
The 110 kDa/Rhop-3 rhoptry protein of Plasmodium falciparum is non-covalently associated with two other proteins, the 140 kDa Rhop-1 and the 130 kDa Rhop-2. cDNAs encoding Rhop-3 from Plasmodium yoelii were isolated using rhoptry-specific antisera from Plasmodium falciparum, P. yoelii, and Plasmodium chabaudi. The cDNAs encoded peptides with partial homology to the C-terminal region (residues 541-861) of P. falciparum Rhop-3. Core regions of homology to the P. falciparum gene will be useful in determining the biological role of Rhop-3 and its potential as a vaccine candidate for malaria.
Anthony
R N
RN
Cleveland State University, Department of Biological, Geological and Environmental Sciences, Ohio 44115, USA.
Yang
J
J
Krall
J A
JA
Sam-Yellowe
T Y
TY
D000595:Amino Acid Sequence; D000818:Animals; D015723:Gene Library; D017125:Genes, Protozoan; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics; D010967:Plasmodium yoelii / Q000235:genetics*; D015800:Protozoan Proteins / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D015800:Protozoan Proteins; C065352:rhoptry associated protein, Plasmodium