title: Increased CSF levels of nerve growth factor in patients with Alzheimer's disease.
abstract: The authors quantitated CSF levels of nerve growth factor (NGF) in patients with AD, nondemented control subjects (CTR), and age-matched patients with major depression (DE). CSF levels of NGF were markedly higher in the AD group than in both the CTR and DE groups (p < 0.01 and p < 0.001). Increased CSF levels of NGF in AD patients may reflect reported accumulation of NGF in the AD brain and may constitute a candidate marker for clinical diagnosis and therapeutic monitoring.
authors.affiliation: Department of Psychiatry Research, University of Zürich, Switerzland.
authors.forename: C
authors.initials: C
authors.lastname: Hock
authors.forename: K
authors.initials: K
authors.lastname: Heese
authors.forename: F
authors.initials: F
authors.lastname: Müller-Spahn
authors.forename: P
authors.initials: P
authors.lastname: Huber
authors.forename: W
authors.initials: W
authors.lastname: Riesen
authors.forename: R M
authors.initials: RM
authors.lastname: Nitsch
authors.forename: U
authors.initials: U
authors.lastname: Otten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003865:Major Depressive Disorder / Q000134:cerebrospinal fluid / Q000175:diagnosis; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000134:cerebrospinal fluid*; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D020932:Nerve Growth Factor