The bactericidal action of penicillin: new clues to an unsolved mystery.
The Staphylococcus aureus lrgAB operon was recently shown to inhibit extracellular murein hydrolase activity and increase tolerance to penicillin. Further characterization of this operon could provide novel insight into the dynamics of S. aureus cell wall metabolism and the mechanism of penicillin-induced lethality.
Bayles
K W
KW
Dept of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844-3052, USA.
D001426:Bacterial Proteins / Q000378:metabolism; D002473:Cell Wall / Q000187:drug effects / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D008565:Membrane Proteins; D009154:Mutation; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000235:genetics / Q000378:metabolism; D009876:Operon; D010406:Penicillins / Q000494:pharmacology*; D015398:Signal Transduction; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000235:genetics
D001426:Bacterial Proteins; C406202:LrgA protein, Staphylococcus aureus; D008565:Membrane Proteins; D010406:Penicillins; D009238:N-Acetylmuramoyl-L-alanine Amidase