Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats.
Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques.
Yeşilada
E
E
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Hipodrom 06330, Ankara, Turkey. yesilada@tr-net.net.tr
Takaishi
Y
Y
Fujita
T
T
Sezik
E
E
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002492:Central Nervous System Depressants; D000431:Ethanol; D005744:Gastric Acid / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007101:Immersion; D008026:Ligation; D008297:Male; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011708:Pylorus; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D014421:Turkey
D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D012503:Saponins; D000431:Ethanol