title: Anti-ulcerogenic effects of Spartium junceum flowers on in vivo test models in rats.
abstract: Flowers of Spartium junceum L. (Fabaceae) are used for the treatment of gastric ulcers in Turkish folk medicine. Through bioassay-guided fractionation using chemical and chromatographical means and water immersion and restraint-induced stress ulcer model in rats, a saponin fraction was determined as the potent anti-ulcerogenic ingredient. The active fraction was also highly effective in preventing ethanol- and pyloric ligation-induced gastric lesions as well as inhibiting gastric secretion volume, gastric pH and titratable acidity, but did not affect the hexosamine content of the gastric mucosa. A novel oleanen-type triterpenic saponin, named as spartitrioside, was isolated as the active principle by using chromatographical separation techniques.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Hipodrom 06330, Ankara, Turkey. yesilada@tr-net.net.tr
authors.forename: E
authors.initials: E
authors.lastname: Yeşilada
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: E
authors.initials: E
authors.lastname: Sezik
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002492:Central Nervous System Depressants; D000431:Ethanol; D005744:Gastric Acid / Q000737:chemistry; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D007101:Immersion; D008026:Ligation; D008297:Male; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011708:Pylorus; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications; D014421:Turkey
chemical_list: D000897:Anti-Ulcer Agents; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D012503:Saponins; D000431:Ethanol