Left-right axis malformations in man and mouse.
The study of left-right axis malformations in man and mouse has greatly advanced understanding of the mechanisms regulating vertebrate left-right axis formation. Recently, the roles of the TGF-beta family, Sonic hedgehog and fibroblast growth factor signaling, homeobox genes, and cilia in left-right axis determination have been more clearly defined. The identification of genes and environmental factors affecting left-right axis formation has important implications for understanding human laterality defects.
Casey
B
B
Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, 77030, USA. bcasey@bcm.tmc.edu
Hackett
B P
BP
D000818:Animals; D004627:Embryonic Induction; D005346:Fibroblast Growth Factors / Q000502:physiology; D005801:Genes, Homeobox; D053823:Hedgehog Proteins; D006801:Humans; D051379:Mice; D011506:Proteins / Q000502:physiology; D012857:Situs Inversus / Q000235:genetics*; D015534:Trans-Activators; D016212:Transforming Growth Factor beta / Q000502:physiology
D053823:Hedgehog Proteins; D011506:Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D005346:Fibroblast Growth Factors