title: Intravenous tufted angioma.
abstract: A case of a rare vascular tumor, intravenous tufted angioma, is described. A 51-year-old Japanese man presented with a 12x8 mm solitary reddish nodule on the right foot, which had been found at birth. Histologically, the tumor was confined to a malformed vein and was characterized by nodular aggregates of plump cells. The aggregates showed a compact proliferation of round cells, including capillary-forming cells. Venous angiomatous areas were also observed. No multinucleated giant cells were seen. Immunohistochemically, the capillary-forming cells in the aggregates and the endothelial cells in the angiomatous areas were positive for endothelial markers (factor VIII-related antigen, CD31, CD34). Pericyte-like cells expressing alpha-smooth muscle actin and muscle actin, and macrophage-like cells, which stained for factor XIIIa, were intermingled in the cellular aggregates. Flow cytometric analysis showed diploidy. The tumor may be a hamartomatous lesion modified by secondary reactive changes, and it may represent a distinctive clinicopathological entity that is closely related histogenetically and perhaps pathologically to tufted angioma and the recently described "giant cell angioblastoma".
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan. maasafu@jikei.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Fukunaga
mesh_terms: D018952:Antigens, CD34 / Q000032:analysis; D005528:Foot; D006391:Hemangioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007564:Japan; D008297:Male; D008875:Middle Aged; D009383:Neoplasms, Vascular Tissue / Q000473:pathology* / Q000601:surgery; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D014680:Veins / Q000002:abnormalities* / Q000473:pathology; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor