title: Cervical intraepithelial neoplasia outcomes after large loop excision with clear margins.
abstract: OBJECTIVE
  To identify risk factors for residual or recurrent cervical intraepithelial neoplasia (CIN) after large loop excision of the transformation zone with clear margins.
  
  
  METHODS
  We did a case-control study of women treated with loop excision for CIN who had adequate follow-up and in whom margins were believed to be clear. Women with clear margins in whom no subsequent lesions were found (controls) were compared with women who presented with subsequent CIN (cases). Epidemiologic and colposcopic risk factors for recurrence were analyzed. Multiple logistic regression analysis was done to identify independent risk factors.
  
  
  RESULTS
  In 31 of 635 women studied (4.9%), subsequent lesions were diagnosed. Univariate analysis identified glandular involvement, satellite lesions, and age over 40 years in cases as significant. Multiple logistic regression analysis confirmed that these three characteristics were independent risk factors, with odds ratios of 4.9 (95% confidence intervals 1.9, 12.3), 19 (7.5, 48.2), and 6.7 (2.8, 15.8), respectively. Subsequent lesions were identified by colposcopy or cytologic testing during the first postoperative year in all but one case.
  
  
  CONCLUSIONS
  Age over 40 years, glandular involvement, and satellite lesions were related to the reappearance of CIN after loop excision with clear margins. These findings could be used to define appropriate follow-up protocols.
authors.affiliation: Department of Gynecology, Ioannina University Hospital, Ioannina, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Paraskevaidis
authors.forename: E D
authors.initials: ED
authors.lastname: Lolis
authors.forename: G
authors.initials: G
authors.lastname: Koliopoulos
authors.forename: Y
authors.initials: Y
authors.lastname: Alamanos
authors.forename: S
authors.initials: S
authors.lastname: Fotiou
authors.forename: H C
authors.initials: HC
authors.lastname: Kitchener
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D016015:Logistic Models; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*