Identification of monozygotic twins that are concordant for preeclampsia.
Preeclampsia is thought to be discordant in monozygotic twins. While recruiting for a genetic study into preeclampsia, we identified 4 sets of twins and a triplet gestation; all were monozygous on deoxyribonucleic acid "fingerprinting." Two twins were concordant for preeclampsia, and 2 of the triplets had pregnancy-induced hypertension, although only 1 of them had proteinuria. Hence we confirm the existence of monozygotic twins that are concordant for preeclampsia.
O'shaughnessy
K M
KM
Clinical Pharmacology Unit, Department of Medicine, University of Cambridge Clinical School, UK. km022@medschl.cam.ac.uk
Ferraro
F
F
Fu
B
B
Downing
S
S
Morris
N H
NH
D004200:Diseases in Twins; D005260:Female; D005838:Genotype; D006801:Humans; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D014310:Triplets; D014430:Twins, Monozygotic