title: Impaired stimulation of intestinal glucose absorption by portal insulin via hepatoenteral nerves in chronically ethanol-intoxicated rats.
abstract: In the isolated, jointly perfused small intestine and liver of rats insulin, infused into the portal vein, induced an increase in intestinal glucose absorption via hepatoenteral cholinergic nerves. The possible loss of function of these nerves due to ethanol-induced neuropathy was investigated with 6 weeks ethanol-fed rats. Portal insulin or arterial carbachol failed to increase intestinal glucose absorption but cAMP still did so. The intact stimulatory effect of cAMP indicated an undisturbed capacity of the enterocytes. The loss of action of portal insulin and of arterial carbachol can be explained by the impairment of the hepatoenteral nerves in line with an ethanol-induced neuropathy.
authors.affiliation: Institute of Biochemistry and Molecular Cell Biology, Georg-August-University, Humboldtallee 23, 37073, Göttingen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Kucera
authors.forename: K
authors.initials: K
authors.lastname: Jungermann
authors.forename: F
authors.initials: F
authors.lastname: Stümpel
mesh_terms: D000042:Absorption / Q000187:drug effects; D020269:Alcoholic Neuropathy / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D000437:Alcoholism / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D003994:Bucladesine / Q000008:administration & dosage / Q000494:pharmacology; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology; D000431:Ethanol / Q000008:administration & dosage / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism*; D007003:Hypoglycemia / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000294:innervation* / Q000378:metabolism* / Q000503:physiopathology; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000294:innervation / Q000378:metabolism; D008297:Male; D010477:Perfusion; D011169:Portal Vein; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D007328:Insulin; D000431:Ethanol; D003994:Bucladesine; D002217:Carbachol; D005947:Glucose