Combined effect of polytetrafluoroethylene and 5-fluorouracil on delayed adjustable strabismus surgery.
OBJECTIVE
To determine a more reliable method for performing delayed suture adjustment to prevent the formation of postoperative adhesions and delay the time of adjustment.


METHODS
Thirty-two rabbit eyes were divided into three groups. After recession of the superior rectus muscle, 5-fluorouracil (5-FU) was administered beneath and over the superior rectus muscle in group 5-FU (12 eyes); polytetrafluoroethylene (PTFE) and 5-FU were administered in group P-f (10 eyes); and PTFE, 5-FU, and Viscoat (chondroitin sulfate, sodium hyaluronate, Alcon Laboratories Inc, Fort Worth, Tex) were administered in group P-fv (10 eyes). Delayed adjustment was performed once on each superior rectus muscle at 1, 2, and 3 weeks postoperatively in group 5-FU and at 2 and 4 weeks postoperatively in groups P-f and P-fv. The length and force for the adjustment and the degree of adhesions were recorded.


RESULTS
The use of fluorouracil allowed adjustment to be delayed up to 1 week after surgery in three of four eyes. The combined use of PTFE and 5-FU or addition of Viscoat allowed adjustment to be delayed for up to 4 weeks after surgery in four of five eyes.


CONCLUSIONS
The combined use of PTFE, 5-FU and Viscoat is useful for delaying suture adjustment in rabbit eyes.
Hwang
J M
JM
Department of Ophthalmology, Seoul Municipal Boramae Hospital, and the College of Medicine, Seoul National University, Korea.
Chang
B L
BL
D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage*; D002807:Chondroitin / Q000008:administration & dosage; D002809:Chondroitin Sulfates; D003131:Combined Modality Therapy; D004338:Drug Combinations; D005472:Fluorouracil / Q000008:administration & dosage*; D006820:Hyaluronic Acid / Q000008:administration & dosage; D009801:Oculomotor Muscles / Q000601:surgery*; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D013285:Strabismus / Q000601:surgery*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000517:prevention & control
D000963:Antimetabolites; D004338:Drug Combinations; C501944:chondroitin sulfate, sodium hyaluronate drug combination; D011138:Polytetrafluoroethylene; D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates; D005472:Fluorouracil