title: The first synthesis of clausenamine-A and cytotoxic activities of three biscarbazole analogues against cancer cells.
abstract: Clausemine-A (3), isolated from the stem and root bark of Clausena excavata, was synthesized using Suzuki cross-coupling and Oxidative coupling as the key step. Compound 3, and the other two structurally related biscarbazoles 1 and 2, showed potent cytotoxic activities against a variety of human cancer cell lines in vitro.
authors.affiliation: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
authors.forename: A
authors.initials: A
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; C413726:clausenamine A