title: The boundary element method in the forward and inverse problem of electrical impedance tomography.
abstract: In this paper, a new formulation of the reconstruction problem of electrical impedance tomography (EIT) is proposed. Instead of reconstructing a complete two-dimensional picture, a parameter representation of the gross anatomy is formulated, of which the optimal parameters are determined by minimizing a cost function. The two great advantages of this method are that the number of unknown parameters of the inverse problem is drastically reduced and that quantitative information of interest (e.g., lung volume) is estimated directly from the data, without image segmentation steps. The forward problem of EIT is to compute the potentials at the voltage measuring electrodes, for a given set of current injection electrodes and a given conductivity geometry. In this paper, it is proposed to use an improved boundary element method (BEM) technique to solve the forward problem, in which flat boundary elements are replaced by polygonal ones. From a comparison with the analytical solution of the concentric circle model, it appears that the use of polygonal elements greatly improves the accuracy of the BEM, without increasing the computation time. In this formulation, the inverse problem is a nonlinear parameter estimation problem with a limited number of parameters. Variants of Powell's and the simplex method are used to minimize the cost function. The applicability of this solution of the EIT problem was tested in a series of simulation studies. In these studies, EIT data were simulated using a standard conductor geometry and it was attempted to find back this geometry from random starting values. In the inverse algorithm, different current injection and voltage measurement schemes and different cost functions were compared. In a simulation study, it was demonstrated that a systematic error in the assumed lung conductivity results in a proportional error in the lung cross sectional area. It appears that our parametric formulation of the inverse problem leads to a stable minimization problem, with a high reliability, provided that the signal-to-noise ratio is about ten or higher.
authors.affiliation: Laboratory of Medical Physics and Informatics, Institute of Cardiovascular Research ICaR-VU, University Hospital Vrije Universiteit, Amsterdam, The Netherlands. jc.munck@azvu.nl
authors.forename: J C
authors.initials: JC
authors.lastname: de Munck
authors.forename: T J
authors.initials: TJ
authors.lastname: Faes
authors.forename: R M
authors.initials: RM
authors.lastname: Heethaar
mesh_terms: D000465:Algorithms; D000818:Animals; D001011:Aorta / Q000502:physiology; D003198:Computer Simulation; D017097:Electric Impedance; D004566:Electrodes; D006801:Humans; D008168:Lung / Q000502:physiology; D008954:Models, Biological; D017711:Nonlinear Dynamics; D012815:Signal Processing, Computer-Assisted; D014054:Tomography / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data