title: Priority assessment of toxic substances in life cycle assessment. Part I: calculation of toxicity potentials for 181 substances with the nested multi-media fate, exposure and effects model USES-LCA.
abstract: Toxicity potentials are standard values used in life cycle assessment (LCA) to enable a comparison of toxic impacts between substances. In most cases, toxicity potentials are calculated with multi-media fate models. Until now, unrealistic system settings were used for these calculations. The present paper outlines an improved model to calculate toxicity potentials: the global nested multi-media fate, exposure and effects model USES-LCA. It is based on the Uniform System for the Evaluation of Substances 2.0 (USES 2.0). USES-LCA was used to calculate for 181 substances toxicity potentials for the six impact categories freshwater aquatic ecotoxicity, marine aquatic ecotoxicity, freshwater sediment ecotoxicity, marine sediment ecotoxicity, terrestrial ecotoxicity and human toxicity, after initial emission to the compartments air, freshwater, seawater, industrial soil and agricultural soil, respectively. Differences of several orders of magnitude were found between the new toxicity potentials and those calculated previously.
authors.affiliation: Interfaculty Department of Environmental Science, Faculty of Environmental Science, University of Amsterdam, The Netherlands. m.huijbregts@frw.uva.nl
authors.forename: M A
authors.initials: MA
authors.lastname: Huijbregts
authors.forename: U
authors.initials: U
authors.lastname: Thissen
authors.forename: J B
authors.initials: JB
authors.lastname: Guinée
authors.forename: T
authors.initials: T
authors.lastname: Jager
authors.forename: D
authors.initials: D
authors.lastname: Kalf
authors.forename: D
authors.initials: D
authors.lastname: van de Meent
authors.forename: A M
authors.initials: AM
authors.lastname: Ragas
authors.forename: A W
authors.initials: AW
authors.lastname: Sleeswijk
authors.forename: L
authors.initials: L
authors.lastname: Reijnders
mesh_terms: D000818:Animals; D017753:Ecosystem; D004781:Environmental Exposure; D020387:Food Chain; D006801:Humans; D008962:Models, Theoretical; D012016:Reference Values; D018570:Risk Assessment; D018675:Toxicity Tests; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D015262:Xenobiotics