title: Diffusion and perfusion magnetic resonance imaging in childhood stroke.
abstract: Two magnetic resonance imaging techniques, diffusion and perfusion imaging, are being used increasingly for evaluation of pathophysiology of stroke. This article introduces these techniques and reports some initial studies using these approaches, together with conventional T2-weighted magnetic resonance imaging, for investigation of childhood stroke. It is shown that the combination of T2-weighted and diffusion images can provide information about the timing of stroke events in childhood, and perfusion imaging can detect abnormalities not visible by other magnetic resonance imaging techniques. These magnetic resonance methods therefore should play an important role in investigation of children with stroke and could be of particular value in studies of at-risk populations of children such as those with sickle cell disease.
authors.affiliation: Radiology and Physics Unit, Institute of Child Health, University College London Medical School, UK. dgadian@ich.ucl.ac.uk
authors.forename: D G
authors.initials: DG
authors.lastname: Gadian
authors.forename: F
authors.initials: F
authors.lastname: Calamante
authors.forename: F J
authors.initials: FJ
authors.lastname: Kirkham
authors.forename: M
authors.initials: M
authors.lastname: Bynevelt
authors.forename: C L
authors.initials: CL
authors.lastname: Johnson
authors.forename: D A
authors.initials: DA
authors.lastname: Porter
authors.forename: W K
authors.initials: WK
authors.lastname: Chong
authors.forename: M
authors.initials: M
authors.lastname: Prengler
authors.forename: A
authors.initials: A
authors.lastname: Connelly
mesh_terms: D000293:Adolescent; D001921:Brain / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D020521:Stroke / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology