title: Abnormal blood flow and red blood cell deformability in severe malaria.
abstract: Obstruction of the microcirculation plays a central role in the pathophysiology of severe malaria. Here, Arjen Dondorp and colleagues describe the various contributors to impaired microcirculatory flow in falciparum malaria: sequestration, rosetting and recent findings regarding impaired red blood cell deformability. The correlation with clinical findings and possible therapeutic consequences are discussed.
authors.affiliation: Department of Internal Medicine, Tropical Medicine and AIDS, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. A.M.Dondorp@AMC.UVA.NL
authors.forename: A M
authors.initials: AM
authors.lastname: Dondorp
authors.forename: P A
authors.initials: PA
authors.lastname: Kager
authors.forename: J
authors.initials: J
authors.lastname: Vreeken
authors.forename: N J
authors.initials: NJ
authors.lastname: White
mesh_terms: D000328:Adult; D000818:Animals; D001783:Blood Flow Velocity; D002648:Child; D004907:Erythrocyte Deformability; D018056:Hemorheology; D006801:Humans; D016778:Malaria, Falciparum / Q000097:blood / Q000503:physiopathology*; D008833:Microcirculation; D010963:Plasmodium falciparum / Q000472:pathogenicity