title: Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature.
abstract: Laryngeal radionecrosis is a difficult late complication of radiotherapy. It is associated with hoarseness, edema, pain, weight loss, and upper airway obstruction. The medical treatment options are limited, and in severe cases, the patient may require tracheostomy or laryngectomy. We report clinical results in 18 patients treated with adjunctive hyperbaric oxygen (HBO) therapy for severe radionecrosis of the larynx. Of these 18 patients, 2 had grade 3 and 16 had grade 4 radionecrosis. The patients received a mean number of 41 HBO treatments (range, 6 to 80) at 2 atmospheres absolute for 2 hours, twice a day, 6 days a week. Thirteen patients (72.2%) had a major improvement after HBO therapy, and none of them required total laryngectomy. All patients preserved their voice and deglutition in good or normal condition. Five patients (27.8%) failed to have a good response to HBO and underwent total laryngectomy. One of these patients had local recurrence of his cancer 4 months later, and the other 3 had significant concurrent medical problems. The remaining patient received only 6 HBO treatments because of emergency heart surgery. These encouraging results are comparable to those of smaller previous studies suggesting that HBO has a beneficial effect in the management of advanced laryngeal radionecrosis.
authors.affiliation: Duke Hyperbaric Center, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Filntisis
authors.forename: R E
authors.initials: RE
authors.lastname: Moon
authors.forename: K L
authors.initials: KL
authors.lastname: Kraft
authors.forename: J C
authors.initials: JC
authors.lastname: Farmer
authors.forename: R L
authors.initials: RL
authors.lastname: Scher
authors.forename: C A
authors.initials: CA
authors.lastname: Piantadosi
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D010039:Otorhinolaryngologic Neoplasms / Q000532:radiotherapy*; D011379:Prognosis; D011832:Radiation Injuries / Q000175:diagnosis / Q000628:therapy*