title: Anaphylaxis caused by neostigmine.
abstract: A patient developed anaphylaxis during anaesthesia, towards the end of surgery, 30 s after intravenous administration of neostigmine. Anaphylaxis to neostigmine was confirmed by demonstrating an elevated mast cell tryptase and a strongly/positive skin prick test, showing the presence of drug-specific IgE (skin prick tests to neostigmine were negative in normal subjects). This is a rare cause of anaphylaxis during anaesthesia.
authors.affiliation: Clinic 2A, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Seed
authors.forename: P W
authors.initials: PW
authors.lastname: Ewan
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000139:chemically induced*; D008875:Middle Aged; D009388:Neostigmine / Q000009:adverse effects*; D012882:Skin Tests
chemical_list: D002800:Cholinesterase Inhibitors; D009388:Neostigmine