title: Dependence of fungistatic activity of 2, 4-dihydroxythiobenzanilideson the structure and lipophilic nature of the compounds.
abstract: The quantitative dependencies of in vitro fungistatic action on the physico-chemical parameters connected with the structure of 2, 4-dihydroxythiobenzanilides were investigated. It was stated that the action of these compounds depends on lipophilicity determined by substitution of the N-aryl moiety and on electron properties of molecules. The lipophilicity expressed by R(Mw) values was determined in the reversed-phase system (HPTLC). The changes in the nature of the thioamide bond were interpreted on the basis of UV and EI-MS spectra.
authors.affiliation: Department of Chemistry, University of Agriculture, Akademicka 15, 20-950, Lublin, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Matysiak
authors.forename: A
authors.initials: A
authors.lastname: Niewiadomy
authors.forename: G
authors.initials: G
authors.lastname: Macik-Niewiadomy
authors.forename: T
authors.initials: T
authors.lastname: Kornillowicz
mesh_terms: D000813:Anilides / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000813:Anilides; D000935:Antifungal Agents