title: Spread of methicillin-resistant Staphylococcus aureus belonging to the Brazilian epidemic clone in a general hospital and emergence of heterogenous resistance to glycopeptide antibiotics among these isolates.
abstract: Methicillin-resistant Staphylococcus aureus (MRSA) infections have been increasing at an alarming rate world-wide. MRSA epidemics due to the clonal spread of multi-resistant isolates have been described. In this paper we show the absolute predominance of MRSA strains from the Brazilian epidemic clone in a hospital in the Northeast region of Brazil and the emergence of a vancomycin and teicoplanin heterogeneous resistant subpopulation among these isolates.
authors.affiliation: Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Prof. Paulo de Góes, Laboratorio de Biologia Molecular de Bacterias, CCS, Bloco I, Cidade Universitária, Rio de Janeiro, RJ, Brazil.
authors.forename: M J
authors.initials: MJ
authors.lastname: dos Santos Soares
authors.forename: M C
authors.initials: MC
authors.lastname: da Silva-Carvalho
authors.forename: B T
authors.initials: BT
authors.lastname: Ferreira-Carvalho
authors.forename: A M
authors.initials: AM
authors.lastname: Figueiredo
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D004196:Disease Outbreaks / Q000517:prevention & control*; D018432:Drug Resistance, Multiple; D016521:Electrophoresis, Gel, Pulsed-Field; D005838:Genotype; D006801:Humans; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011110:Polymorphism, Genetic; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics