[Effect of testosterone and progesterone on carboxypeptidase H activity in the hypothalamo-hypophyseal-gonadal axis and the adrenal gland in mice].
Testosterone propionate decreased activity of carboxypeptidase H in the male mongrel mice pituitary gland, activity of the CP H in testicles, and increased these parameters in 4 hours after treatment. Progesterone decreased the CP H activity in pituitary gland and increased it in testicles. Progesterone increased the CP H activity in female pituitary gland and decreased it in adrenal gland and hypothalamus. The role of the CP H in the effects of the sex steroids on the function of peptidergic systems is discussed.
Vernigora
A N
AN
Penza State Pedagogical University, Russia.
Saldaev
D A
DA
Gengin
M T
MT
D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D043423:Carboxypeptidase H; D002268:Carboxypeptidases / Q000378:metabolism*; D005260:Female; D006066:Gonads / Q000201:enzymology*; D007030:Hypothalamo-Hypophyseal System / Q000201:enzymology*; D008297:Male; D051379:Mice; D010053:Ovary / Q000201:enzymology; D011374:Progesterone / Q000494:pharmacology*; D013737:Testis / Q000201:enzymology; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D011374:Progesterone; D002268:Carboxypeptidases; D043423:Carboxypeptidase H
Vliianie testosterona i progesterona na aktivnost' karboksipeptidazy H v gipotalamo-gipofizarno-gonadal'noĭ osi i nadpochechnikakh mysheĭ.