title: Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.
abstract: The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.
authors.affiliation: Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Onodera
authors.forename: H
authors.initials: H
authors.lastname: Shinoda
authors.forename: H
authors.initials: H
authors.lastname: Mayanagi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced*; D051379:Mice; D009924:Organ Culture Techniques; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*; D012886:Skull / Q000187:drug effects
chemical_list: C001419:hydroxyphenytoin; D010672:Phenytoin