title: Clinical parameters (body mass index and age) are the best predictors for the need of insulin therapy during the first 18 months of diabetes mellitus in young adult patients.
abstract: To address the question whether there are simple clinical predictors of need for insulin in the first 18 months of treatment of diabetes presenting in young adult subjects, a prospective study of 24 patients with diabetes mellitus (age: 18-40 years) was designed. At diagnosis of diabetes, age, sex, body mass index (BMI), glycemia, ketonuria, C-peptide, insulin autoantibodies, islet cell antibodies and glutamic acid decarboxylase antibodies were recorded before starting any treatment. At the end of the follow-up (18 +/- 4 months), they were divided into two groups according to their need for insulin therapy: group 1 (n=15; 62%), who needed insulin therapy, and group 2 (n=9; 38%), who did not. Each marker was related to actual need for therapy necessity. Multivariate analysis showed that BMI and age were the variables with greatest predictive value regarding need for insulin. These data reveal that the need for insulin therapy in young adult diabetic patients may be supported by the clinical criteria of age and BMI, which are both easily and quickly determined.
authors.affiliation: Department of Internal Medicine, University Hospital Puerta del Mar, Cádiz, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Guerrero
authors.forename: J
authors.initials: J
authors.lastname: Ortego
authors.forename: J A
authors.initials: JA
authors.lastname: Córdoba
authors.forename: J A
authors.initials: JA
authors.lastname: Girón
authors.forename: J M
authors.initials: JM
authors.lastname: Freire
authors.forename: M
authors.initials: M
authors.lastname: Aguilar
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers; D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D007515:Islets of Langerhans / Q000201:enzymology / Q000276:immunology; D007659:Ketones / Q000652:urine; D008297:Male; D011237:Predictive Value of Tests
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D007659:Ketones; D005968:Glutamate Decarboxylase