Genetic determinants of arterial thrombosis.
This chapter describes examples of genetic variation involved in the function or regulation of a number of haemostatic proteins involved in the thrombotic process. In each case, the data suggest associations between genotype and disease and, particularly in the case of fibrinogen, PAI-1, Factor VII and Factor XIII, there is interaction between genotype and environment in determination of the relevant plasma level, providing a possible explanation for the differential response of individuals to their environment.
Grant
P J
PJ
Unit of Molecular Vascular Medicine, Research School of Medicine, University of Leeds, The General Infirmary, UK.
Humphries
S E
SE
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000209:etiology / Q000235:genetics; D001161:Arteriosclerosis / Q000097:blood / Q000235:genetics; D001779:Blood Coagulation Factors / Q000009:adverse effects / Q000235:genetics / Q000378:metabolism; D014644:Genetic Variation; D006801:Humans; D009203:Myocardial Infarction / Q000097:blood / Q000235:genetics; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000235:genetics / Q000378:metabolism; D011110:Polymorphism, Genetic; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000209:etiology / Q000235:genetics*
D001779:Blood Coagulation Factors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex