title: Immunization of pediatric solid organ transplant candidates and recipients.
abstract: Organ transplantation has evolved from an experimental procedure to an accepted treatment for otherwise irreversible or congenital disorders. The immunosuppression necessary to prevent rejection enhances the severity of many infectious diseases and may potentially attenuate the response to vaccines designed to prevent disease. In spite of the frequency and severity of infectious diseases in organ transplant recipients, many children are not fully vaccinated before transplantation. The safety and efficacy of many of the currently available vaccines for solid organ transplant recipients have not been evaluated. We review the currently available data on immunization safety and efficacy, discuss experimental vaccines, and outline strategies to avoid vaccine-preventable diseases in pediatric organ transplant recipients.
authors.affiliation: Department of Pediatrics, Division of Pediatric Infectious Diseases, Recanati-Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. peggy.burroughs@mssm.edu
authors.forename: M
authors.initials: M
authors.lastname: Burroughs
authors.forename: A
authors.initials: A
authors.lastname: Moscona
mesh_terms: D000293:Adolescent; D001424:Bacterial Infections / Q000517:prevention & control; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D016377:Organ Transplantation; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage*; D014777:Virus Diseases / Q000517:prevention & control
chemical_list: D001428:Bacterial Vaccines; D014765:Viral Vaccines