Sipandinolide: a butenolide including a novel type of carbon skeleton from Siparuna andina.
From a lipophilic extract of leaves of Siparuna andina (Monimiaceae), which exhibited antiplasmodial activity in vitro, two new compounds have been isolated: sipandinolide (1), a compound with a novel type of carbon skeleton and (-)-cis-3-acetoxy-4',5,7-trihydroxyflavanone (2). Their structures were established by spectroscopic methods; 2 showed moderate antiplasmodial activity whereas 1 was inactive.
Jenett-Siems
K
K
Siems
K
K
Jakupovic
J
J
Solis
P N
PN
Gupta
M P
MP
Mockenhaupt
F P
FP
Bienzle
U
U
Eich
E
E
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects
D000962:Antimalarials; D007783:Lactones; C412408:sipandinolide; D002244:Carbon