Picornavirus RNA translation: roles for cellular proteins.
Picornavirus RNA is translated within cells even when cellular cap-dependent protein synthesis is blocked. The efficiency of recognition of the viral RNA by the translational apparatus can determine viral tropism. The roles of cellular translation-initiation factors and other RNA-binding proteins in viral RNA-mediated protein synthesis are discussed.
Belsham
G J
GJ
BBSRC Institute for Animal Health, Pirbright, Woking, Surrey, UK GU24 0NF. graham.belsham@bbsrc.ac.uk
Sonenberg
N
N
D020121:5' Untranslated Regions / Q000235:genetics; D002478:Cells, Cultured; D006801:Humans; D010849:Picornaviridae / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D012367:RNA, Viral / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism
D020121:5' Untranslated Regions; D011506:Proteins; D012367:RNA, Viral; D014764:Viral Proteins