title: Aneurysmal bone cyst of the spine with familial incidence.
abstract: METHODS
  A report of two cases of aneurysmal bone cysts of the spine occurring in a father and daughter.
  
  
  OBJECTIVE
  To present an unusual finding of familial incidence of aneurysmal bone cyst and review the literature.
  
  
  BACKGROUND
  Aneurysmal bone cysts are benign, expanding, locally aggressive lesions. Up to 20% of cases involve the spine. The cause of primary aneurysmal bone cysts remains unclear. There have been three previous reports of a familial incidence supporting the importance of a hereditary component in the cause of aneurysmal bone cysts.
  
  
  METHODS
  A 36-year-old man and a 7-year-old girl were diagnosed with aneurysmal bone cyst involving the spine by clinical manifestations, radiographic features, and histologic evaluation.
  
  
  RESULTS
  The father remains recurrence- and symptom-free 6 years after primary resection. Five months after surgery, the daughter was found to have recurrent disease by magnetic resonance imaging and underwent a second procedure within 1 year of the primary resection.
  
  
  CONCLUSIONS
  The occurrence of a primary aneurysmal bone cyst in two family members, occurring at adjacent vertebral levels, is suggestive of a hereditary component to the formation of primary aneurysmal bone cyst.
authors.affiliation: Departments of Orthopaedics and Rehabilitation and Pathology, Yale University School of Medicine, New Haven, CT 06520-8071, USA. dicaprio@javanet.com
authors.forename: M R
authors.initials: MR
authors.lastname: DiCaprio
authors.forename: M J
authors.initials: MJ
authors.lastname: Murphy
authors.forename: R L
authors.initials: RL
authors.lastname: Camp
mesh_terms: D000328:Adult; D017824:Bone Cysts, Aneurysmal / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D002648:Child; D005192:Family Health; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery; D014057:Tomography, X-Ray Computed