New antiarrhythmic agents: a conceptually novel approach.
Synthesis and biological evaluation of novel phenoxyalkyl amines exhibiting both class Ib and class III type electrophysiological properties are described. Two compounds showed excellent antiarrhythmic effects against reperfusion induced arrhythmias.
Mátyus
P
P
Institute of Organic Chemistry, Semmelweis University, Budapest, H-1092, Högyes u. 7, Hungary. matypet@szerves.sote.hu
Rettegi
T
T
Varró
A
A
Papp
J G
JG
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013329:Structure-Activity Relationship
D000588:Amines; D000889:Anti-Arrhythmia Agents