Reorganization of adult rat barrel cortex intrinsic signals following kainic acid induced central lesion.
A plasticity model studying the adult rat barrel cortex intrinsic signal after a central lesion was developed. Repeated optical imaging studies of the barrel cortex of five rats were performed over variable periods of time (2 days to 6 weeks) after intracortical injection of kainic acid. The signal of the elicited principal whisker corresponding to the injected barrel in the repeat studies relocated to the perimeter of the lesion. The area of the signals of this principal whisker and of surrounding whiskers were larger in the first two weeks studies than those obtained before injection (P<0.01) resulting in increase overlapping of adjacent signals (P=0.01). Even though the signal of the PW remains relocated in the later studies (>2 weeks), all the signals returned to normal size. These findings demonstrate recovery and reorganization of sensory representation in the somatosensory cortex following a central lesion.
Nguyen
T T
TT
Department of Neurosurgery, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA.
Yamamoto
T
T
Stevens
R T
RT
Hodge
C J
CJ
D000367:Age Factors; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D003714:Denervation; D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid; D009434:Neural Pathways; D009473:Neuronal Plasticity / Q000502:physiology*; D055095:Optics and Photonics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000166:cytology* / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation
D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid