title: Choroidal metastasis as the initial manifestation of a pigmented neuroendocrine tumor.
abstract: We report the case of a 77-year-old woman in whom choroidal metastasis was the initial manifestation of a primary neoplasm presumed to be a pigmented pulmonary carcinoid tumor. The tumor initially was misdiagnosed cytologically and pathologically as a choroidal melanoma because it contained intrinsic melanin pigment. Positive immunoreactivity for cytokeratin, synaptophysin, chromogranin, and calcitonin and the presence of dense-core neurosecretory vesicles disclosed by electron microscopy established that the metastasis was a neuroendocrine tumor. Findings from systemic evaluation suggested that the primary tumor was located in the lung. The patient subsequently developed an intradural paraspinal metastasis, which also contained melanin pigment. The latter observation confirmed that the melanin in the uveal metastasis was intrinsic and did not represent secondary phagocytosis by tumor cells. Metastases from pigmented tumors of nonmelanocytic derivation are exceedingly rare but present a major diagnostic challenge to ocular pathologists and cytopathologists if the diagnosis is not suspected. Confirmatory immunohistochemical analysis should be obtained when a pigmented choroidal tumor thought to be a melanoma has atypical features. Arch Ophthalmol. 2000;118:841-845
authors.affiliation: Department of Pathology, Wills Eye Hospital, 900 Walnut St, Philadelphia, PA 19107-5597, USA.
authors.forename: R C
authors.initials: RC
authors.lastname: Eagle
authors.forename: H
authors.initials: H
authors.lastname: Ehya
authors.forename: J A
authors.initials: JA
authors.lastname: Shields
authors.forename: C L
authors.initials: CL
authors.lastname: Shields
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001984:Bronchial Neoplasms / Q000737:chemistry / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000556:secondary*; D002830:Choroid Neoplasms / Q000737:chemistry / Q000556:secondary*; D002864:Chromogranins / Q000032:analysis; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D009363:Neoplasm Proteins / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D002864:Chromogranins; D009363:Neoplasm Proteins; D016708:Synaptophysin; D007633:Keratins