Scavenger receptor regulation and atherosclerosis.
Atherosclerosis and its complications, such as coronary heart disease, heart infarction and stroke, are the leading causes of death in the developed world. High blood pressure, diabetes, smoking and a diet high in cholesterol and lipids clearly increase the likelihood of premature atherosclerosis, albeit other factors, such as the individual genetic makeup, may play an additional role. During atherosclerosis, uncontrolled cholesterol and lipid accumulation in macrophages and smooth muscle cells leads to foam cell formation and to the progression of the atherosclerotic plaque. This review will focus on foam cell formation within the atherosclerotic lesion, the involvement of the scavenger receptor genes in this process, and the possibility to interfere with scavenger receptor function to reduce the progression of atherosclerosis. To date, the regulatory mechanisms for the expression of scavenger receptor genes and their role in atherosclerosis are not well characterized. Knowledge on this subject could lead to a better understanding of the process, prevention and therapy of this disease.
Zingg
J M
JM
Institute of Biochemistry and Molecular Biology, University of Bern, Switzerland.
Ricciarelli
R
R
Azzi
A
A
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D002784:Cholesterol / Q000378:metabolism; D005487:Foam Cells / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D050356:Lipid Metabolism; D008264:Macrophages / Q000502:physiology*; D008565:Membrane Proteins; D011971:Receptors, Immunologic / Q000235:genetics / Q000502:physiology*; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B
D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B; D002784:Cholesterol