Molecular basis of spatio-temporal dynamics in inositol 1,4,5-trisphosphate-mediated Ca2+ signalling.
Inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ signalling regulates many important cell functions, and the spatio-temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility. The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns. I also discuss the spatio-temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration. These findings highlight the potential importance of the spatio-temporal information of any signalling molecule.
Iino
M
M
Department of Pharmacology, Graduate School of Medicine, University of Tokyo, Japan.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000145:classification / Q000502:physiology; D020013:Calcium Signaling; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology*; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear / Q000145:classification / Q000502:physiology
D015220:Calcium Channels; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium