Postoperative stroke in a child with cerebral palsy heterozygous for factor V Leiden.
A 5-year-old with spastic quadraparetic cerebral palsy suffered multiple strokes after extensive orthopedic surgery. Coagulation testing was undertaken to determine whether a familial thrombophilia was present. The patient was found to be heterozygous for factor V Leiden. Factor V Leiden may be a risk factor for central nervous system events in special-needs children, particularly when common medical conditions create additional procoagulant risks.
Steiner
M
M
Department of Pediatrics, Fairview-University Medical Center, Minneapolis, University of Minnesota, 55455, USA.
Hodes
M Z
MZ
Shreve
M
M
Sundberg
S
S
Edson
J R
JR
D001929:Brain Edema / Q000209:etiology; D002545:Brain Ischemia / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000209:etiology; D002547:Cerebral Palsy / Q000150:complications*; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005166:Factor V Deficiency / Q000150:complications* / Q000235:genetics; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D020244:Infarction, Middle Cerebral Artery / Q000209:etiology*; D020766:Intracranial Embolism / Q000209:etiology*; D008297:Male; D019637:Orthopedic Procedures; D018458:Persistent Vegetative State / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology*; D011782:Quadriplegia / Q000150:complications*; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications* / Q000235:genetics; D020246:Venous Thrombosis / Q000209:etiology
C095381:factor V Leiden; D005165:Factor V