[MUC genes: a superfamily of genes? Towards a functional classification of human apomucins].
The MUC genes encode epithelial mucins. Eight different human genes have been well characterized, and two others identified more recently. Among them, a family of four genes, expressed in the respiratory and digestive tracts, is clustered to chromosome 11p15.5; and these genes encode gel-forming mucins which are structurally related to the superfamily of cystine-knot growth factors. A second group is composed of three independent genes encoding various isoforms of mucins including membrane-bound mucins associated to carcinomas. In this second group, MUC3 and MUC4 encode large apomucins containing EGF-like domains.
Porchet
N
N
Unité INSERM n(o) 377, Lille.
Buisine
M P
MP
Desseyn
J L
JL
Moniaux
N
N
Nollet
S
S
Degand
P
P
Pigny
P
P
Van Seuningen
I
I
Laine
A
A
Aubert
J P
JP
D000595:Amino Acid Sequence; D001059:Apoproteins / Q000235:genetics*; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D004848:Epithelium / Q000378:metabolism; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D055263:Mucin-3; D055264:Mucin-4; D009077:Mucins / Q000235:genetics*; D005810:Multigene Family; D016415:Sequence Alignment
D001059:Apoproteins; D006133:Growth Substances; C524658:MUC4 protein, human; D055263:Mucin-3; D055264:Mucin-4; D009077:Mucins
Gènes MUC: une superfamille de gènes? Vers une classification fonctionnelle des apomucines humaines.