title: Expression of interferon alpha/beta receptor in human hepatocellular carcinoma.
abstract: Interferon-alpha (IFNalpha) plays a crucial role in the antiproliferation and immunoregulatory activity through the specific cell surface receptor, interferon-alpha/beta receptor (IFNalpha/betaR). We examined the immunohistochemical expression of IFNalpha/betaR in 91 hepatocellular carcinoma (HCC), HCV-related chronic hepatitis (n=38) and cirrhosis (n=53), dysplastic nodules (n=5), and normal liver (n=9). The level of IFNalpha/betaR increased in chronic hepatitis and cirrhosis compared with normal liver. All the dysplastic nodules showed moderate or high expression. In HCCs, 26% (24/91) of patients showed high IFNalpha/betaR expression while the remaining 38% (35/91) showed moderate, and 35% (32/91) no or faint expression. Clinicopathological survey demonstrated a significant correlation between IFNalpha/betaR expression and differentiation of carcinoma (P=0.0008) although there was no correlation between IFNalpha/betaR expression in HCC and survival or disease-free survival. Thus, IFNalpha/betaR was expressed not only in chronic hepatitis or liver cirrhosis but in HCC and its expression was significantly correlated with tissue differentiation of carcinoma.
authors.affiliation: Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kondo
authors.forename: H
authors.initials: H
authors.lastname: Nagano
authors.forename: M
authors.initials: M
authors.lastname: Sakon
authors.forename: H
authors.initials: H
authors.lastname: Yamamoto
authors.forename: O
authors.initials: O
authors.lastname: Morimoto
authors.forename: I
authors.initials: I
authors.lastname: Arai
authors.forename: A
authors.initials: A
authors.lastname: Miyamoto
authors.forename: H
authors.initials: H
authors.lastname: Eguchi
authors.forename: K
authors.initials: K
authors.lastname: Dono
authors.forename: S
authors.initials: S
authors.lastname: Nakamori
authors.forename: K
authors.initials: K
authors.lastname: Umeshita
authors.forename: K
authors.initials: K
authors.lastname: Wakasa
authors.forename: Y
authors.initials: Y
authors.lastname: Ohmoto
authors.forename: M
authors.initials: M
authors.lastname: Monden
mesh_terms: D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D005260:Female; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D008103:Liver Cirrhosis / Q000276:immunology / Q000473:pathology; D008113:Liver Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000276:immunology* / Q000473:pathology; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000032:analysis*
chemical_list: D008565:Membrane Proteins; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta