Evaluation of the antiviral activity of kaempferol and its glycosides against human cytomegalovirus.
The antiviral activity of seven flavonoids, belonging to the kaempferol series, was evaluated against human cytomegalovirus (HCMV) by a rapid method of detection of the immediate-early (IE) antigen, induced by the virus in infected cells. Flavonoids bearing acyl substituents were found to be the most active compounds.
Mitrocotsa
D
D
Mitaku
S
S
Axarlis
S
S
Harvala
C
C
Malamas
M
M
D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D005069:Evaluation Studies as Topic; D005419:Flavonoids; D006027:Glycosides / Q000494:pharmacology*; D006801:Humans; D044949:Kaempferols; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D005419:Flavonoids; D006027:Glycosides; D044949:Kaempferols; C006552:kaempferol; D011794:Quercetin