title: Deafness from eighth cranial nerve involvement in a patient with large-cell transformation of mycosis fungoides.
abstract: Central nervous system (CNS) involvement by mycosis fungoides (MF) is rare and is usually seen in advanced stages with lymph node or visceral involvement. We describe a patient with advanced stage MF in large-cell transformation who presented with profound hearing loss after chemotherapy. Despite an initial differential diagnosis of vincristine-related neurotoxicity based on clinical, audiometric, and MRI investigations, CSF examination revealed lymphomatous leptomeningeal involvement. This case illustrates the importance of an awareness of the possibility of CNS involvement by MF and underlines the need for a complete neurologic evaluation including CSF examination in a patient with underlying MF who presents with a new neurological problem.
authors.affiliation: Division of Haematology and Medical Oncology, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia.
authors.forename: S L
authors.initials: SL
authors.lastname: Chua
authors.forename: J F
authors.initials: JF
authors.lastname: Seymour
authors.forename: H M
authors.initials: HM
authors.lastname: Prince
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003390:Cranial Nerve Neoplasms / Q000150:complications*; D003638:Deafness / Q000209:etiology*; D064420:Drug-Related Side Effects and Adverse Reactions; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009182:Mycosis Fungoides / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D009367:Neoplasm Staging; D014057:Tomography, X-Ray Computed; D000159:Vestibulocochlear Nerve