[Effect of antiretroviral treatment and prophylaxis for opportunistic infections on survival of patients with AIDS].
OBJECTIVE
To analyze the influence of anti-retroviral therapy (ART) and prophylaxis against opportunist disease on survival of patients with AIDS.


METHODS
Study of AIDS patients diagnosed from January 1996 to October 1997 in a Madrid hospital. An analysis was made of demographic, clinical, and immunological data, as well as ART and prophylaxis against Pneumocystis carinii pneumonia (PCP) and tuberculosis (TB). Both univariate and multivariate analyses were performed, as well as Kaplan-Meier curves.


RESULTS
A total of 205 patients were included in the study (83% male) with a median age of 34 years. ART, PCP prophylaxis, and TB prophylaxis were received by 147 (72%), 141 (69%) and 22 (11%) patients, respectively. Among individuals on ART, the likelihood of survival at 12 and 22 months since diagnosis of AIDS was made was 79% and 76%, respectively, and among non treated individuals 54% and 54%, respectively (p < 0.05). ART was associated with a 57% decrease in death risk, and regarding PCP prophylaxis, no benefit on survival was found.


CONCLUSIONS
ART was significantly associated with a lower risk of death among AIDS patients. The survival rate was not increased with PCP prophylaxis.
Gálvez Hermoso
C
C
Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid.
Blanco Quintana
F
F
del Amo Valero
J
J
Díez Ruiz-Navarro
M
M
Soriano Vázquez
V
V
González Lahoz
J
J
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000401:mortality* / Q000517:prevention & control*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000401:mortality* / Q000517:prevention & control*; D012189:Retrospective Studies; D012306:Risk; D015996:Survival Rate; D014376:Tuberculosis / Q000401:mortality* / Q000517:prevention & control*
D019380:Anti-HIV Agents
Efecto del tratamiento antirretrovírico y de la profilaxis para enfermedades oportunistas en la supervivencia de los pacientes con SIDA.