title: Decreased cerebrospinal fluid levels of beta-phenylethylamine in patients with Rett syndrome.
abstract: To clarify the mechanism of brain impairment in Rett syndrome, we measured the cerebrospinal fluid levels of beta-phenylethylamine (PEA) in 17 patients with Rett syndrome. Findings were compared with those obtained in age-matched controls and diseased controls. The cerebrospinal fluid level of PEA was significantly lower in patients with Rett syndrome than in the controls (31% of control values). The alteration in the cerebrospinal fluid level of PEA may reflect dopamine system impairment in Rett syndrome.
authors.affiliation: Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Satoi
authors.forename: T
authors.initials: T
authors.lastname: Matsuishi
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: E
authors.initials: E
authors.lastname: Ohtaki
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: R
authors.initials: R
authors.lastname: Riikonen
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: A K
authors.initials: AK
authors.lastname: Percy
mesh_terms: D000328:Adult; D000368:Aged; D001321:Autistic Disorder / Q000134:cerebrospinal fluid; D002648:Child; D004827:Epilepsy / Q000134:cerebrospinal fluid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008875:Middle Aged; D010627:Phenethylamines / Q000134:cerebrospinal fluid*; D012016:Reference Values; D015518:Rett Syndrome / Q000134:cerebrospinal fluid* / Q000503:physiopathology
chemical_list: D010627:Phenethylamines; C029261:phenethylamine