title: [D8/17 marker: implication to neuropsychiatry].
abstract: Recent studies suggest that there is a relationship between rheumatic fever (RF) and some neuropsychiatric disorders. Thus, it has been thought that autoimmune mechanisms might be related to the etiology of these neuropsychiatric disorders. It has also been demonstrated that a B cell alloantigen associated to RF is also abnormally overexpressed in patients with such neuropsychiatric disorders. This alloantigen is recognised by a monoclonal antibody known as D8/17. The aim of this article is to introduce the recent work done about D8/17 and its possible implications to the study of neuropsychiatric disorders related or not to RF.
authors.affiliation: Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo.
authors.forename: J
authors.initials: J
authors.lastname: Diniz
authors.forename: P G
authors.initials: PG
authors.lastname: Alvarenga
authors.forename: A
authors.initials: A
authors.lastname: Hounie
authors.forename: E C
authors.initials: EC
authors.lastname: Miguel
mesh_terms: D000911:Antibodies, Monoclonal / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D002819:Chorea / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007519:Isoantigens / Q000032:analysis* / Q000276:immunology*; D001523:Mental Disorders / Q000150:complications / Q000276:immunology*; D009771:Obsessive-Compulsive Disorder / Q000276:immunology; D012213:Rheumatic Fever / Q000150:complications / Q000276:immunology*; D005879:Tourette Syndrome / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; C082034:B-cell alloantigen D8-17; D015415:Biomarkers; D007519:Isoantigens
vernacular_title: Marcador D8-17: implicações para a neuropsiquiatria.