Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
Herreman
A
A
Neuronal Cell Biology Laboratory, CME, K.U.Leuven and Flanders Interuniversitary Institute for Biotechnology (VIB4), Belgium.
Serneels
L
L
Annaert
W
W
Collen
D
D
Schoonjans
L
L
De Strooper
B
B
D000544:Alzheimer Disease / Q000201:enzymology; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D053764:Presenilin-1; D053766:Presenilin-2; D013234:Stem Cells / Q000201:enzymology* / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D053764:Presenilin-1; D053766:Presenilin-2; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse