Alkaloids of Andrachne aspera.
Two new 2,6-disubstituted piperidine alkaloids andrachcinine (1) and andrachcinidine (5) have been isolated from Andrachne aspera along with andrachamine and andrachcine (2). The absolute configurations of 1, 2, and 5 were established. (+)-Allosedridine and the new alkaloids (-)-8-epi-8-ethylnorlobelol I (4) and (-)-8-epihalosaline (7) were also identified as constituents of A. aspera. Structures were determined by MS and NMR techniques and by chemical conversions.
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Organic Chemistry Department (CP 160/06), University of Brussels, 50 Avenue F. D. Roosevelt, B-1050 Brussels, Belgium.
Hootelé
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D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D019665:Euphorbiaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008956:Models, Chemical; D010880:Piperidines / Q000737:chemistry / Q000302:isolation & purification*
D000470:Alkaloids; D010880:Piperidines; C412672:andrachcinine