Effect of gold on survival of tumor-bearing mice.
Sodium aurothiomalate (monogold monosodium mono-hydrogen sulfidobutanedioate), an anti-rheumatoid gold agent, was injected s.c. every other day for three times or given in drinking water daily for two weeks to Balb/C mice that were inoculated with syngeneic Meth/A cells i.p. As the control, cisplatinum was injected s.c. Survival curve was then observed and significance was determined by Wilcoxon's method. Statistically significant effects on survivals was obtained by 30 mg/kg/day s.c. or 75 mg/kg/day p.o. of gold. A dose of less than 12.5 mg/kg/day s.c. adversely affected the survival. Cisplatinum was significantly effective at the dose of 12.5 mg/kg/day, but markedly toxic at the dose of 125 mg/kg and adversely effective at 6 mg/kg/day s.c. The range of dose effectiveness of cisplatinum on survival was narrower than that of gold. Gold was effective when given s.c. or p.o. No significant toxicity of gold was observed at doses up to 125 mg/kg/day.
Kamei
H
H
Department of Surgery, Aichi-Gakuin University Hospital, Nagoya, Japan. kamei@dpc.aichi-gakuin.ac.jp
Koide
T
T
Kojima
T
T
Hashimoto
Y
Y
Hasegawa
M
M
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016019:Survival Analysis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018501:Antirheumatic Agents; D006052:Gold Sodium Thiomalate; D002945:Cisplatin