title: Ultrasound biomicroscopic analysis of the human ciliary body after 1 and 2% pilocarpine instillation.
abstract: We examined ciliary body thickness (CBT) of 11 human eyes after 1% followed by 2% pilocarpine instillation using ultrasound biomicroscopy. The examination revealed that CBT decreased in 2 eyes after 1% pilocarpine treatment but increased after 2% pilocarpine. In the eyes with decreased CBT by 1% pilocarpine, the pretreatment ciliary bodies were thicker and the changing rate of CBT induced by 2% pilocarpine, although not decreased, was also smaller than that in CBT-increased eyes. These findings showed that the ciliary body was under relatively strong stimulus of endogenous acetylcholine and has subsensitivity to both 1 and 2% pilocarpine in CBT-decreased eyes. Configurative changes in CBT-decreased eyes may be explained by the localization of different muscarinic receptor subtypes in different portions of the ciliary muscle.
authors.affiliation: Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Miyagi, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Arakawa
authors.forename: M
authors.initials: M
authors.lastname: Tamai
mesh_terms: D000328:Adult; D002924:Ciliary Body / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D018721:Muscarinic Agonists / Q000008:administration & dosage*; D009130:Muscle, Smooth / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage*; D011976:Receptors, Muscarinic / Q000378:metabolism; D012016:Reference Values; D015203:Reproducibility of Results; D014463:Ultrasonography
chemical_list: D018721:Muscarinic Agonists; D009883:Ophthalmic Solutions; D011976:Receptors, Muscarinic; D010862:Pilocarpine