Redox-dependent signal transduction.
Reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide appear to be transiently produced in response to growth factor and cytokine stimulation. A variety of evidence suggests that this ligand-stimulated change in the cellular redox state participates in downstream signal transduction. This review will focus on the effects of ROS on signal transduction pathways, the molecules that regulate intracellular ROS production and the potential protein targets of oxidants.
Finkel
T
T
Laboratory of Molecular Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bldg 10/6N-240, 10 Center Drive, 20892-1622, Bethesda, MD, USA. finkelt@nih.gov
D000818:Animals; D006801:Humans; D008954:Models, Biological; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000502:physiology; D015398:Signal Transduction
D017382:Reactive Oxygen Species