Review: peptidases and peptidase inhibitors in the pathogenesis of diseases. Disturbances in the ubiquitin-mediated proteolytic system. Protease-antiprotease imbalance in inflammatory reactions. Role of cathepsins in tumour progression.
Bank
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U
Institute of Immunology, Otto-von-Guericke-University, Halle.
Krüger
S
S
Langner
J
J
Roessner
A
A
D017204:Angelman Syndrome / Q000201:enzymology; D002403:Cathepsins / Q000502:physiology; D003546:Cysteine Endopeptidases / Q000502:physiology; D003550:Cystic Fibrosis / Q000235:genetics; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000378:metabolism; D004194:Disease / Q000209:etiology*; D018450:Disease Progression; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000201:enzymology*; D008025:Ligases / Q000172:deficiency / Q000235:genetics; D008247:Lysosomes / Q000201:enzymology; D008565:Membrane Proteins / Q000378:metabolism; D008666:Metalloendopeptidases / Q000502:physiology; D009097:Multienzyme Complexes / Q000502:physiology; D009154:Mutation; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000201:enzymology*; D019636:Neurodegenerative Diseases / Q000201:enzymology; D010447:Peptide Hydrolases / Q000172:deficiency / Q000187:drug effects / Q000502:physiology*; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D046988:Proteasome Endopeptidase Complex; D015843:Serpins / Q000502:physiology; D019714:Tissue Inhibitor of Metalloproteinases / Q000502:physiology; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000502:physiology; D019896:alpha 1-Antitrypsin Deficiency / Q000201:enzymology
C505032:CFTR protein, human; D016326:Extracellular Matrix Proteins; D008565:Membrane Proteins; D009097:Multienzyme Complexes; D009363:Neoplasm Proteins; D011480:Protease Inhibitors; D015843:Serpins; D019714:Tissue Inhibitor of Metalloproteinases; D014452:Ubiquitins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D044767:Ubiquitin-Protein Ligases; D002403:Cathepsins; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D008666:Metalloendopeptidases; D046988:Proteasome Endopeptidase Complex; D008025:Ligases