title: Does the route of feeding modify gastric emptying in rats?
abstract: BACKGROUND
  It has been shown that the pattern of previous nutrient intake can influence gastric emptying. However, the effect of the absence of enteral stimulation in the setting of a normal energy supply on gastric emptying has not been examined. The aim of this study was to determine whether the absence of enteral stimulation during total parenteral nutrition (TPN) could modify gastric emptying in rats.
  
  
  METHODS
  Two experiments were performed. First, gastric emptying of a peptone meal was compared between rats receiving TPN, oral liquid diet (same solution as TPN), or regular diet (control group) for 10 days. In the second experiment, gastric emptying of two test meals (40% peptone and 25% glucose) was studied before and after rats received TPN or intragastric nutrition (same solution as TPN) for 10 to 12 days.
  
  
  RESULTS
  In experiment 1, gastric emptying of 40% peptone in the TPN and liquid diet groups was slower than that in the control group. This difference was significant between the TPN group and the control group (p < .01) but not between the liquid diet and control groups (p = .076). Gastric emptying of this meal in the TPN and liquid diet groups was similar. In experiment 2, no difference in gastric emptying of 40% peptone or 25% glucose was found between rats receiving TPN and those receiving intragastric nutrition for 10 to 12 days.
  
  
  CONCLUSIONS
  The composition of diet not the route of feeding is important in the modification of gastric emptying by the pattern of previous nutrient intake.
authors.affiliation: Centre de Recherche en Nutrition Humaine, CRI-INSERM 95/08 CHU Hôtel-Dieu, Nantes, France.
authors.forename: G
authors.initials: G
authors.lastname: Shi
authors.forename: C
authors.initials: C
authors.lastname: Cherbut
authors.forename: S B
authors.initials: SB
authors.lastname: des Varannes
authors.forename: C
authors.initials: C
authors.lastname: Rozé
authors.forename: J P
authors.initials: JP
authors.lastname: Galmiche
mesh_terms: D000818:Animals; D004032:Diet / Q000009:adverse effects*; D004750:Enteral Nutrition; D005248:Feeding Methods; D005746:Gastric Emptying / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage; D008297:Male; D010288:Parenteral Nutrition; D010461:Peptones / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010461:Peptones; D005947:Glucose