Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle.
Initially characterized as Drosophila developmental regulators, the BTB/POZ and zinc finger proteins (BTB/POZ-ZF) constitute a growing family of proteins with gene expression regulatory functions since they have been shown to be involved in both transcriptional activation and repression of various genes in a broad range of species, including mammals. Here we report the cloning of a novel human transcript, coding for a 68-kDa deduced BTB/POZ-ZF protein. This molecule, called myoneurin on the basis of its prevalent expression in the neuromuscular system, contains an amino-terminal BTB/POZ domain and eight tandemly repeated zinc-finger motifs of the C(2)H(2) type. The murine myoneurin, identified in the mouse embryo, is highly homologous to the human protein.
Alliel
P M
PM
Institut National de la Santé et de la Recherche Médicale, U488, Bâtiment Gregory Pincus, 80 rue du Général Leclerc, Le Kremlin Bicêtre cedex, 94276, France. alliel@infobiogen.fr
Seddiqi
N
N
Goudou
D
D
Cifuentes-Diaz
C
C
Romero
N
N
Velasco
E
E
Rieger
F
F
Périn
J P
JP
D000375:Aging; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins; D004622:Embryo, Mammalian / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D051741:Kruppel-Like Transcription Factors; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D018482:Muscle, Skeletal / Q000378:metabolism*; D009928:Organ Specificity; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D020449:Repetitive Sequences, Amino Acid; D012097:Repressor Proteins / Q000737:chemistry*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics*; D016335:Zinc Fingers
C402243:ABTB1 protein, human; C509774:Abtb1 protein, mouse; D004268:DNA-Binding Proteins; D051741:Kruppel-Like Transcription Factors; C410903:MYNN protein, human; C503846:Mynn protein, mouse; D012333:RNA, Messenger; D012097:Repressor Proteins; D014157:Transcription Factors