title: Detoxification of reactive intermediates during microbial metabolism of halogenated compounds.
abstract: The reactivity and toxicity of metabolic intermediates that are generated by initial biotransformation reactions can be a major limiting factor for biodegradation of halogenated organic compounds. Recent work on the conversion of haloalkanes, chloroaromatics and chloroethenes indicates that microorganisms may become less sensitive to toxic effects either by using novel pathways that circumvent the generation of reactive intermediates or by producing modified enzymes that decrease the toxicity of such compounds.
authors.affiliation: NIZO Food Research, PO Box 20, Ede, 6710 BA, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: van Hylckama Vlieg
authors.forename: G J
authors.initials: GJ
authors.lastname: Poelarends
authors.forename: A E
authors.initials: AE
authors.lastname: Mars
authors.forename: D B
authors.initials: DB
authors.lastname: Janssen
mesh_terms: D001421:Bacteria, Anaerobic / Q000201:enzymology*; D001426:Bacterial Proteins / Q000378:metabolism; D004798:Enzymes / Q000378:metabolism; D006219:Halogens / Q000737:chemistry / Q000378:metabolism*; D007218:Industrial Microbiology / Q000379:methods*; D007220:Industrial Waste
chemical_list: D001426:Bacterial Proteins; D004798:Enzymes; D006219:Halogens; D007220:Industrial Waste