[Improved liposome encapsulated hemoglobin by electret technology and its influence on the blood rheologic behavior in vitro].
To study the influence of different electret properties of Liposome Encapsulated Hemoglobin(LEH) on the blood rheologic behavior in vitro, four kinds of LEH have been prepared. Their electret properties have been determined by using Thermally Stimulated Depolarization Current(TSDC). The results show that 4# LEH, whose Ta is 12 degrees C and Ia is -5.6 x 10(-9) A, has the best electret property, furthermore, the results of the thrombus formation in vitro also show that the addition of 4# LEH induces the lightest thrombus figuration in vitro. It is obvious that the rational improvement of the electret property of LEH can meliorate the surface charge of blood and effectively inhibit the formation of thrombus.
Deng
B
B
Laboratory of Biomaterials, Beijing Institute of Technology.
Shi
X
X
Deng
J
J
Sun
C
C
Wong
W
W
Wang
Y
Y
D001809:Blood Viscosity; D006454:Hemoglobins / Q000008:administration & dosage*; D006801:Humans; D008081:Liposomes; D013927:Thrombosis / Q000517:prevention & control
D006454:Hemoglobins; D008081:Liposomes