title: Inhibition of human immunodeficiency virus type 1 replication in primary CD4(+) T lymphocytes, monocytes, and dendritic cells by cytotoxic T lymphocytes.
abstract: We demonstrate that human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) cytotoxic T lymphocytes (CTL) suppress HIV-1 replication in primary lymphocytes, monocytes, and dendritic cells individually. Viral inhibition is significantly diminished in lymphocyte-dendritic cell clusters, suggesting that these clusters in vivo could be sites where viral replication is more difficult to control by CTL.
authors.affiliation: AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Severino
authors.forename: N V
authors.initials: NV
authors.lastname: Sipsas
authors.forename: P T
authors.initials: PT
authors.lastname: Nguyen
authors.forename: S A
authors.initials: SA
authors.lastname: Kalams
authors.forename: B D
authors.initials: BD
authors.lastname: Walker
authors.forename: R P
authors.initials: RP
authors.lastname: Johnson
authors.forename: O O
authors.initials: OO
authors.lastname: Yang
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000276:immunology* / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000821:virology; D014779:Virus Replication