[Treatment of maternal hyperthyroidism and fetal goiter].
A fetal goitre is a potentially dangerous phenomenon because of mechanical obstruction and possible fetal thyroid function disorders. During pregnancy women with a history of Graves' disease under treatment with propylthiouracil (PTU) have an increased risk for fetal goitre. In this report a patient with Graves' disease diagnosed in early pregnancy and treated with PTU which resulted in a fetal goitre is described. The fetal thyroid status, investigated by percutaneous fetal umbilical cord blood sampling, was normal and the reduction of PTU dosage was sufficient to decrease goitre volume.
Bellini
P
P
III Clinica Ostetrica e Ginecologica, Università degli Studi, Milano.
Marinetti
E
E
Arreghini
A
A
Andreotti
C
C
Kirm
V
V
Roncaglia
N
N
D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005315:Fetal Diseases / Q000139:chemically induced*; D006042:Goiter / Q000139:chemically induced*; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011441:Propylthiouracil / Q000008:administration & dosage / Q000009:adverse effects
D013956:Antithyroid Agents; D011441:Propylthiouracil
Trattamento dell'ipertiroidismo materno e gozzo fetale.