[Preparation, characterization and drug release characteristics of poly(lactide)(PL)/poly(lactide-co-polyethylene glycol)(PLEG) blend microspheres].
PL and PLEG are biodegradable, biocompatible polymers. They have been widely used for controlled release of drugs. We synthesized PLEG copolymers containing PEG segments with various molecular weight and prepared hCG-loaded PL/PLEG blend microspheres to improve hCG entrapment efficiency. It was shown that the hCG entrapment effciency of PL/PLEG microspheres was higher than that of PL or PLEG microspheres when P(L-co-PEG6000)(90:10) was used. In vitro release test showed that the release of hCG was a burst-slow process, which was thought to be good for antigens to produce antibodies.
Jiang
H
H
Department of Polymer Science and Engineering, Zhejiang University, Hangzhou.
Zhu
K
K
D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems; D008863:Microspheres; D011091:Polyesters; D011092:Polyethylene Glycols
D006063:Chorionic Gonadotropin; D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide)