Haemostasis in patients with Behçet's disease.
OBJECTIVE
to determine whether Behçet's disease affects haemostatic function.


METHODS
University Hospital, Turkey.


METHODS
one hundred and twenty-seven consecutive patients with Behçet's disease, 34 of whom with a history of vascular involvement.


METHODS
prothrombin fragment 1+2 tissue plasminogen activator, protein S and C, antithrombin, fibrinogen, von Willebrand factor, thrombomodulin and prothrombin time (PT) were measured in patient plasma.


RESULTS
soluble thrombomodulin was significantly lower and von Willebrand factor (vWF) and tissue plasminogen activator (tPA) significantly higher in Behçet's patients. Patients with vascular involvement showed the highest levels of vWF and tPA. There was no activation of coagulation, not even in patients with an active disease at the time of sampling.


CONCLUSIONS
there were indirect signs of endothelial activity or damage, particularly in patients with vascular involvement. Coagulation was not activated.
Demirer
S
S
Department of Surgery, Ankara University Hospital, Turkey.
Sengül
N
N
Yerdel
M A
MA
Tüzüner
A
A
Ulus
A T
AT
Gürler
A
A
Bergqvist
D
D
Siegbahn
A
A
Karacagil
S
S
D000328:Adult; D000991:Antithrombins / Q000378:metabolism; D001528:Behcet Syndrome / Q000097:blood*; D015415:Biomarkers; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D012720:Severity of Illness Index; D018180:Thrombomodulin / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
D000991:Antithrombins; D015415:Biomarkers; D010446:Peptide Fragments; D011486:Protein C; D017293:Protein S; D018180:Thrombomodulin; C045879:prothrombin fragment 1.2; D014841:von Willebrand Factor; D011516:Prothrombin; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator