title: Involvement of nitric oxide from nerves on diarrhea induced by castor oil in rats.
abstract: Nitric oxide (NO) is involved in the mechanism of castor oil-induced diarrhea. This study was performed to elucidate the source of NO. Diarrhea was induced by oral administration of castor oil in rats. Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole. This effect was attenuated by the treatment with L-arginine. Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea. N(G)-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats. These data suggest, at least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.
authors.affiliation: Meiji Institute of Health Science, Odawara, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Matsueda
authors.forename: R
authors.initials: R
authors.lastname: Shoda
authors.forename: A
authors.initials: A
authors.lastname: Muraoka
authors.forename: S
authors.initials: S
authors.lastname: Yamato
mesh_terms: D000818:Animals; D002368:Castor Oil / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009569:Nitric Oxide; D002368:Castor Oil; D019331:NG-Nitroarginine Methyl Ester