Central administration of alpha-melanocyte stimulating hormone inhibits fasting- and neuropeptide Y-induced feeding in neonatal chicks.
In the present study, the effect of intracerebroventricular (i.c.v.) administration of alpha-melanocyte stimulating hormone (alpha-MSH) on food intake of neonatal chicks was examined. In experiment 1, i.c. v. injection of alpha-MSH (0.04, 0.2 and 1 microg) significantly inhibited food intake of 3-h fasted chicks in a dose-dependent manner. In experiment 2, alpha-MSH strongly inhibited neuropeptide Y-induced feeding when neuropeptide Y (2.5 microg) and several doses of alpha-MSH were given simultaneously i.c.v. These results suggest that alpha-MSH plays an important role in the regulation of food intake of neonatal chicks.
Kawakami
S
S
Department of Animal Production, Kyushu National Agricultural Experiment Station, 861-1192, Kumamoto, Japan.
Bungo
T
T
Ando
R
R
Ohgushi
A
A
Shimojo
M
M
Masuda
Y
Y
Furuse
M
M
D000818:Animals; D000831:Animals, Newborn; D002645:Chickens; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D005215:Fasting / Q000502:physiology*; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology*; D000521:alpha-MSH / Q000494:pharmacology*
D009478:Neuropeptide Y; D000521:alpha-MSH