[Adhesion molecules as the strategic goal of immunotherapy].
Adhesion molecules are cell surface glycoproteins involved in cell-cell and cell-matrix interactions. They play a central role in leukocyte adhesion to endothelium, transmigration, binding to target cells and cytotoxicity. Many pathological processes underlie abnormal cell-cell interactions in the organism. The adhesion molecules are critical for the communication mechanism between cells in inflammatory and immunologic response. The control of cell-cell adhesive interactions, i.e. modulation of adhesion molecules, is an important strategy for anti-inflammatory therapy. (Ref. 65.)
Horvathova
M
M
Department of Clinical Immunology, Institute of Preventive and Clinical Medicine, Bratislava. bll@fmed.uniba.sk
Ferencik
M
M
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000502:physiology / Q000627:therapeutic use*; D002450:Cell Communication / Q000502:physiology; D006801:Humans; D007167:Immunotherapy
D015815:Cell Adhesion Molecules
Adhezívne molekuly ako strategický ciel' imunoterapie.