title: Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoamino acids.
abstract: Ndelta-Fmoc protected nucleoamino acids of type I (Base = T, C, A) have been synthesized and employed as building blocks for the construction of novel polyamide based nucleic acid analogues. Homopyrimidine oligomer A binds to complementary RNA with significant affinity and in a sequence-specific fashion, while no binding was observed to complementary DNA.
authors.affiliation: Novartis Pharma AG, TA Oncology Research, Basel, Switzerland. karl-heinz.altmann@pharma.novartis.com
authors.forename: K H
authors.initials: KH
authors.lastname: Altmann
authors.forename: D
authors.initials: D
authors.lastname: Hüsken
authors.forename: B
authors.initials: B
authors.lastname: Cuenoud
authors.forename: C
authors.initials: C
authors.lastname: García-Echeverría
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018076:DNA, Complementary / Q000737:chemistry; D009693:Nucleic Acid Hybridization / Q000379:methods*; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D009757:Nylons / Q000138:chemical synthesis* / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D018075:RNA, Complementary / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000596:Amino Acids; D018076:DNA, Complementary; D009696:Nucleic Acids; D009757:Nylons; D011759:Pyrrolidines; D018075:RNA, Complementary