Combinatorial chemistry and contemporary pharmacology.
Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high-throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development.
Lazo
J S
JS
Departments of Pharmacology and Chemistry, University of Pittsburgh, PA 15261, USA. lazo+@pitt.edu
Wipf
P
P
D020650:Combinatorial Chemistry Techniques; D019151:Peptide Library; D010600:Pharmacology
D019151:Peptide Library