title: Neuromodulation of the prefrontal cortex during sleep: a microdialysis study in rats.
abstract: To test the hypothesis that biogenic amines of the prefrontal cortex are involved in state-dependent cortical and behavioural activation, changes in extracellular levels of serotonin (5-HT), dopamine (DA), and noradrenaline (NA) were determined during the sleep-wake cycle in freely moving rats using microdialysis probes with parallel EEG recording. Serotonin gradually increased up to 450% during wakefulness (W) as compared to slow wave sleep (SWS), before decreasing toward stable levels during the next episode of SWS. Dopamine and its metabolite homovanillic acid (HVA) were reduced during W as compared to SWS. Although contradictory with the generally admitted enhancement of DA activity related to vigilance, this may be due to the particular role of DA neurons in the prefrontal cortex. However, DA and HVA showed dramatic changes announcing the transition between SWS and W. During paradoxical sleep (PS), DA and 5-HT showed complex changes, the direction of which depended on whether PS was followed by SWS or W. Biogenic amines of the prefrontal cortex are probably involved in cortical and behavioural activation.
authors.affiliation: Division of Neuropsychiatry, University Hospital of Geneva, Chêne-Bourg, Switzerland.
authors.forename: Z
authors.initials: Z
authors.lastname: de Saint Hilaire
authors.forename: M
authors.initials: M
authors.lastname: Orosco
authors.forename: C
authors.initials: C
authors.lastname: Rouch
authors.forename: A
authors.initials: A
authors.lastname: Python
authors.forename: S
authors.initials: S
authors.lastname: Nicolaidis
mesh_terms: D000818:Animals; D004298:Dopamine / Q000378:metabolism; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D018377:Neurotransmitter Agents / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000502:physiology*; D012894:Sleep Stages / Q000502:physiology
chemical_list: D018377:Neurotransmitter Agents; D012701:Serotonin; D004298:Dopamine; D006719:Homovanillic Acid