Myelin widenings and MGUS-IgA: an immunoelectron microscopic study.
A few studies have reported a variety of nonspecific histological lesions in patients with IgA monoclonal gammopathies and polyneuropathy. In our case, using electron microscopy, we observed widenings of the myelin lamellae identical to those commonly described in IgM neuropathies with anti-myelin-associated glycoprotein activity. Using immunoelectron microscopy, we demonstrated a direct involvement of IgA in myelin lesions. The search for a direct link between monoclonal dysglobulinemia, regardless of type, and polyneuropathy is important and may influence treatment.
Vallat
J M
JM
Service de Neurologie, CHU Dupuytren, Limoges, France.
Tabaraud
F
F
Sindou
P
P
Preux
P M
PM
Vandenberghe
A
A
Steck
A
A
D000368:Aged; D015933:Complement C3d / Q000032:analysis; D006801:Humans; D017098:IgA Deficiency / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008475:Median Nerve / Q000503:physiopathology; D016253:Microscopy, Immunoelectron / Q000379:methods; D009186:Myelin Sheath / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D018992:Myelin-Associated Glycoprotein / Q000032:analysis; D010265:Paraproteinemias / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000503:physiopathology; D011826:Radial Nerve / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D013979:Tibial Nerve / Q000503:physiopathology; D014459:Ulnar Nerve / Q000503:physiopathology
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D018992:Myelin-Associated Glycoprotein; D015933:Complement C3d