title: The response to splenectomy in pediatric patients with idiopathic thrombocytopenic purpura who fail high-dose intravenous immune globulin.
abstract: BACKGROUND
  A recent article by Law et al concluded that patients with idiopathic thrombocytopenic purpura (ITP) who have a poor response to intravenous immune globulin (IgG) are unlikely to have a good or excellent response to surgical splenectomy.
  
  
  METHODS
  The authors studied retrospectively 23 pediatric patients age 11.7 +/- 1.0 years with ITP who had been treated with IgG before undergoing splenectomy. As in the aforementioned article, the responses to the 2 treatments were classified on the basis of the platelet count as poor (<50,000/mm3), good (50,000 to 150,000/mm3), or excellent (>150,000/mm3). For patients who received multiple IgG treatments, both initial and final treatment responses were analyzed.
  
  
  RESULTS
  Sixteen patients had an excellent or good initial response to IgG. Of these 16 patients, 14 had an excellent or good response to splenectomy. Among the 7 patients who had a poor response to IgG there were 3 who had an excellent or good response to splenectomy (43%), and 4 patients who had a poor response to splenectomy. A good or excellent response to initial treatment with IgG was associated with a significant probability of a good or excellent response to splenectomy (P = .045).
  
  
  CONCLUSIONS
  A good or excellent response to IgG may be predictive of a favorable response to splenectomy. However, a poor response to IgG does not preclude a satisfactory response to splenectomy in pediatric patients with ITP.
authors.affiliation: Department of Surgery, The University of Michigan Medical Center, Ann Arbor 48109, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Hemmila
authors.forename: D S
authors.initials: DS
authors.lastname: Foley
authors.forename: V P
authors.initials: VP
authors.lastname: Castle
authors.forename: R B
authors.initials: RB
authors.lastname: Hirschl
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D008297:Male; D010976:Platelet Count; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D013156:Splenectomy; D017211:Treatment Failure
chemical_list: D016756:Immunoglobulins, Intravenous