Transgenic farm animals: applications in agriculture and biomedicine.
During the last decade, tremendous progress has been made in the area of transgenic farm animals. While there are many important transgenic farm animal applications in agriculture, funding has been very limited and progress has been rather slow in this area. Encouragingly, the potential applications of transgenic farm animals as bioreactors for producing human therapeutic proteins and as organ donors for transplantations in humans have attracted vast funding from the private sectors. Several transgenic animal products are already in various phases of clinical trials. Estimates are, that in the near future, the worlds demands on human pharmaceutical proteins may largely be met by transgenic farm animals. While there are still major challenges ahead in the area of xenotransplantation using transgenic animal organs, transgenic tissues or cells have demonstrated promising results as a potential tool for gene therapy. Recent development on cloning, embryonic stem cells and alternative transgenic methods may further expand the transgenic applications in both agriculture and biomedicine.
Yang
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X
Department of Animal Science, University of Connecticut, Storrs 06269-4040, USA. Xyang@ANSC1.CAG.UCONN.Edu
Tian
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XC
Dai
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Y
Wang
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B
D000383:Agriculture / Q000379:methods* / Q000639:trends; D000822:Animal Husbandry; D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D030801:Animals, Genetically Modified; D001709:Biotechnology / Q000379:methods*; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D019076:Transgenes; D014183:Transplantation, Heterologous