Idiopathic hypertrophic cranial pachymeningitis with perifocal brain edema--case report.
A 51-year-old female presented with an extremely rare case of idiopathic hypertrophic cranial pachymeningitis manifesting as markedly thickened frontotemporal meninges with expanding perifocal edema. Magnetic resonance imaging with gadolinium revealed enhancement of the thickened dura mater protruding into the brain parenchyma accompanied by focal edema causing a mass effect. Histological examination of a biopsy specimen revealed thickened dura with infiltrating lymphocytes. Serological and immunological tests were normal. No inflammatory response or evidence of malignant tumors was observed. The patient was treated with predonisolone, resulting in marked improvement of the mass effect. High-dose steroid therapy appears to be effective for intracranial pachymeningitis associated with expanding perifocal brain edema.
Nakazaki
H
H
Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan.
Tanaka
T
T
Isoshima
A
A
Hida
T
T
Nakajima
M
M
Abe
T
T
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D001929:Brain Edema / Q000209:etiology; D003399:Craniotomy; D004388:Dura Mater / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D011239:Prednisolone