[The prevention of suppurative-septic complications in severe burns by using immunotropic drug preparations in an experiment].
The prophylactic and therapeutic action of immunotropic preparations in different doses on the development of Pseudomonas infection of experimental animals with thermal burns was evaluated. Natural marrow and thymic regulatory peptides (myelopid, tactivin and thymalin), as well as the synthetic immunopreparation polyoxydonium, were used for immunocorrection. The study revealed that the injection of these immunomodulators in doses recommended by instructions for use did not affect the course of the infectious process, antibody production by immunocompetent cells and the death rate of experimental animals. The use of the course dose of any of these substances, introduced in a single injection, prevented the generalization of infection. The death rate of experimental animals dropped from 80.3% to 47.2%.
Pylaeva
S I
SI
Research Institute of Traumatology and Orthopedics, Nizhny Novgorod, Russia.
Gordinskaia
N A
NA
Vazina
I R
IR
Sidorkin
V G
VG
Bushuev
Iu I
IuI
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D002056:Burns / Q000150:complications* / Q000276:immunology / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008815:Mice, Inbred Strains; D011552:Pseudomonas Infections / Q000209:etiology / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic
Profilaktika gnoĭno-septicheskikh oslozhneniĭ pri tiazhelykh ozhogakh s pomoshch'iu immunotropnykh lekarstvennykh preparatov v éksperimente.