title: Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives.
abstract: Cephalosporins with 3-pyazolylpyridinium at C-3 position, which is supposed to exhibit synergic activity of ceftazidime and cefoselis, were synthesized and their antibacterial activity against gram-positive and gram-negative was inspected.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.
authors.forename: K Y
authors.initials: KY
authors.lastname: Chang
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: G
authors.initials: G
authors.lastname: Nam
authors.forename: J H
authors.initials: JH
authors.lastname: Seo
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
authors.forename: D C
authors.initials: DC
authors.lastname: Ha
mesh_terms: D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds