title: As well as physiological states, pathological states and therapeutical problems may be a gushing spring for biological theory--and conversely.
abstract: New class of therapies, including bipolar therapies (BPT) and "paradoxical" unipolar therapies (PUT) were firstly proposed in relation to a clinical insight and to some results of biological investigations, then they gave rise to mathematical modeling which brought a justification of these therapies, at least from a theoretical point of view. After recalling the mathematical model for the regulation of agonistic antagonistic couples, and reporting the fundamental types of control simulation by means of it, we point out the validity of therapeutical applications inferred from this model. These therapy modalities, including BPT and PUT, now concern the following diseases: astrocytomas, epilepsia and trials on multiple sclerosis. Even if such attempts are in their early stage, noticeably for the last case where biological changes have mainly been studied, it seems that a large span of treatments is open to BPT and PUT. Improvement of these techniques in the future depends, in our opinion, on a parallel working on the dynamics of the mathematical model and the dynamics, perceived by clinical insight and confirmed by biological investigations, of the body reactions to such strategies. Justification of BPT and PUT was given, by resorting to the notion of "pathological homeostasis" which, too often, intervenes in order to nullify the effects of unilateral (not paradoxical) therapies. This research has elicited some therapies which use two agents with antagonistic effects or only an agent with effects similar to the agent already in excess in the body--in both cases at nearly physiological doses.
authors.affiliation: Fondation A. de Rothschild, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Bernard-Weil
authors.forename: F
authors.initials: F
authors.lastname: Mikol
authors.forename: M F
authors.initials: MF
authors.lastname: Monge-Strauss
authors.forename: P
authors.initials: P
authors.lastname: Jung
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000305:Adrenal Cortex Hormones / Q000502:physiology; D000818:Animals; D001254:Astrocytoma / Q000503:physiopathology* / Q000628:therapy; D001921:Brain / Q000503:physiopathology; D001932:Brain Neoplasms / Q000503:physiopathology* / Q000628:therapy; D003198:Computer Simulation; D004827:Epilepsy / Q000503:physiopathology* / Q000628:therapy; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008962:Models, Theoretical; D009103:Multiple Sclerosis / Q000503:physiopathology* / Q000628:therapy; D014667:Vasopressins / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D014667:Vasopressins