Tau aggregation into fibrillar polymers: taupathies.
Different neurological disorders, known as taupathies have been recently described. In these disorders it has been suggested that modifications in the microtubule-associated protein tau could cause neural degeneration in specific regions. Although these regions are different in the different taupathies, some common features appear to occur in all of them: abnormal hyperphosphorylation of tau and aberrant tau aggregation. These two features are commented upon in this review.
Avila
J
J
Centro de Biología Molecular 'Severo Ochoa' (UAM-CSIC), Facultad de Ciencias, Universidad Autónoma de Madrid, 28049, Madrid, Spain. javila@cbm.uam.es
D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D006801:Humans; D010766:Phosphorylation; D016875:tau Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D016875:tau Proteins