title: The effect of beta-blockers on health-related quality of life in patients with heart failure.
abstract: Beta-blockers reduce the risk of death in patients with heart failure and are recommended in those with stable class II or III disease despite optimal standard therapy. Health-related quality of life (HRQOL) is an increasingly important end point in clinical trials. We reviewed all studies that determined the effect of beta-blockers on HRQOL in patients with heart failure. In these trials, HRQOL was assessed by the Quality of Life Questionnaire in Severe Heart Failure and the Minnesota Living with Heart Failure Questionnaire. Three of the 10 studies that used either of these instruments reported significant improvements in scores. When HRQOL was determined by a single-question global assessment, substantial improvements were observed by patients and physicians in five of the seven studies that used the instrument. Possible reasons for the lack of consistent effect on HRQOL include lack of responsiveness of currently available instruments, incomplete data collection, and true lack of effect of beta-blockers on HRQOL in these patients.
authors.affiliation: School of Pharmacy, University of Connecticut, Storrs, USA.
authors.forename: P
authors.initials: P
authors.lastname: Reddy
authors.forename: A B
authors.initials: AB
authors.lastname: Dunn
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D017298:Bisoprolol / Q000627:therapeutic use; D002227:Carbazoles / Q000627:therapeutic use; D000077261:Carvedilol; D002986:Clinical Trials as Topic; D006304:Health Status; D006333:Heart Failure / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008790:Metoprolol / Q000627:therapeutic use; D011412:Propanolamines / Q000627:therapeutic use; D011788:Quality of Life
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D008790:Metoprolol; D017298:Bisoprolol