title: 1H magnetic resonance imaging of human lung using inversion recovery turbo spin echo.
abstract: Evaluation of lung pathologies using magnetic resonance imaging remains limited, primarily due to the lung's low proton density and high density of magnetic field susceptibility gradients. It is hypothesized that visualization of the lung is possible if signal intensity from muscle and/or fat is suppressed or reduced. Using the inversion recovery and frequency selective saturation pulse with a half-Fourier single-shot turbo spin-echo (HASTE) or a segmented, centric reordered turbo spin-echo (TSE) readout, signal intensity and contrast of tissues can be manipulated to enhance the visibility of the lung. Multislice images of the lung from 10 healthy volunteers were acquired with negligible motion artifacts. Peripheral pulmonary vessels appear well delineated. T(1) maps of the lung are also presented; the overall average was 1335 +/- 85 msec and 1245 +/- 93 msec with the volunteers performing breath-holding on end-expiration and end-inspiration, respectively. This difference is statistically significant, at P < 0.01.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA. vmmai@caregroup.havard.edu
authors.forename: V M
authors.initials: VM
authors.lastname: Mai
authors.forename: J
authors.initials: J
authors.lastname: Knight-Scott
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Keilholz-George
authors.forename: S S
authors.initials: SS
authors.lastname: Berr
mesh_terms: D000328:Adult; D005069:Evaluation Studies as Topic; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011856:Radiographic Image Enhancement / Q000379:methods*; D012016:Reference Values; D012680:Sensitivity and Specificity