Effect of interleukin-11 on body temperature in afebrile and febrile rats.
Interleukin (IL)-11 is a member of the gp130 family of cytokines. In contrast to IL-6 (another gp130 cytokine), IL-11 does not induce fever in humans. In the present study, the effect of recombinant human IL-11 (hrIL-11) injected intracerebroventricularly on body temperature of afebrile and febrile rats was studied. Results showed that: (i) hrIL-11 in doses of 5, 50 and 500 ng injected into the cerebral ventricles does not alter body temperature in rats; (ii) febrile response induced by intraperitoneal injection of E. coli endotoxin (50 microg/kg) was initiated more rapidly in rats injected with 500 ng of hrIL-11 in the cerebral ventricles, and (iii) the enhancement of the initial phase of fever induced by hrIL-11 was not accompanied by changes in plasma concentrations of IL-6 and tumor necrosis factor (TNF). These results indicate that hrIL-11 is not pyrogenic when administered into the brain ventricles. The data obtained also demonstrate that central application of hrIL-11 alters body temperature in conditions of pyrogenic stimulation, but that this effect is not due to the alterations in plasma concentrations of IL-6 or TNF. These data suggest that during the development of the systemic inflammatory response, activation of gp130 subunit becomes effective in altering body temperature.
Gourine
A V
AV
Lovelace Respiratory Research Institute, Albuquerque, NM, USA.
Rudolph
K
K
Leon
L R
LR
Kluger
M J
MJ
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects* / Q000276:immunology*; D005334:Fever / Q000139:chemically induced / Q000276:immunology*; D006822:Hybrid Cells; D007031:Hypothalamus / Q000502:physiology; D007276:Injections, Intraventricular; D017370:Interleukin-11 / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D013047:Specific Pathogen-Free Organisms; D020542:Third Ventricle; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D017370:Interleukin-11; D015850:Interleukin-6; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha