title: The ribosome--a macromolecular machine par excellence.
abstract: The ribosome is the site in the cell where proteins are synthesized. Cryo-electron microscopy and X-ray crystallography have revealed the ribosome as a particle made of two subunits, each formed as an intricate mesh of RNAs and many proteins. Ligand-binding experiments followed by cryo-electron microscopy have helped to determine some of the key stages of interaction between the ribosome and the main ligand molecules.
authors.affiliation: Department of Biomedical Science, Howard Hughes Medical Institute, Health Research, Inc., Wadsworth Center, State University of New York at Albany, Albany, 12201-0509 ,USA. joachim@wadsworth.org.
authors.forename: J
authors.initials: J
authors.lastname: Frank
mesh_terms: D020285:Cryoelectron Microscopy; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D011487:Protein Conformation; D012269:Ribosomal Proteins / Q000096:biosynthesis / Q000737:chemistry; D012270:Ribosomes / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D012269:Ribosomal Proteins