[Mechanism of tumorigenesis caused by tumor suppressor gene].
Hereditary cancer syndrome is mainly caused by tumor suppressor genes, such as p53 gene in Li-Fraumeni syndrome and p16 gene in familial melanoma. There are 2 signal pathways of regulation of cell cycle, RB pathway and p53 pathway. Cyclin dependent kinase(CDK) was regulated by CDK inhibitor(CDKI) (p16, p15), and CDK-CDKI complex control RB by phosphorylation. p53 regulate RB pathway through p21. p53 is involved in apoptosis through bcl 2 or Bax 3. p19 coded by exon 1 beta and exons 2 and 3 of p16 gene, binds to MDM2 and regulate p53 pathway. Chromosome 9p21 locus, which p16, p15 and p19 genes are assigned, is important to regulate both RB and p53 pathways.
Hayashi
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Y
Department of Pediatrics, Faculty of Medicine, University of Tokyo.
D017209:Apoptosis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D020868:Gene Silencing; D016161:Genes, Retinoblastoma / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000502:physiology; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics
D018844:Cyclin-Dependent Kinases