title: Non-specific viral infections as possible synchronising events of the manifestation of type 1 diabetes.
abstract: Four cases of simultaneous manifestation of Type 1 diabetes in two members of the same household are reported. In all cases, a flu-like infection preceded diabetes onset. Surprisingly, despite simultaneous development of insulin dependency, insulin requirements were strikingly different at 3 months in all cases. These observations suggest that increased insulin resistance during infection may cause insulin deficiency in individuals with widely varying residual beta cell activity.
authors.affiliation: German Diabetes Research Institute at the University of Düsseldorf, Germany.
authors.forename: H E
authors.initials: HE
authors.lastname: Wasmuth
authors.forename: G
authors.initials: G
authors.lastname: Hess
authors.forename: C
authors.initials: C
authors.lastname: Viergutz
authors.forename: H R
authors.initials: HR
authors.lastname: Henrichs
authors.forename: S
authors.initials: S
authors.lastname: Martin
authors.forename: H
authors.initials: H
authors.lastname: Kolb
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007333:Insulin Resistance; D008297:Male; D014777:Virus Diseases / Q000150:complications*
chemical_list: D007328:Insulin