Effect of dothiepin on gastric ulceration mediated by lipid derived eicosanoids.
Dothiepin, a tricyclic antidepressant, significantly inhibited the development of gastric ulcers induced by alcohol, aspirin, indomethacin and Shay's pyloric ligation. Antisecretory studies in pyloric ligated rats revealed that the drug at a dose of 100 mg/kg significantly reduced total acidity, gastric output and protein content. In another set of experiments, dothiepin significantly reduced gastric output, total acidity and protein content in pyloric ligated rats which received 50% alcohol (v/v) 30 minutes after the administration of dothiepin.
Sen
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Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Abdul Salam
C A
CA
Pal
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Sen
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Nag Chaudhuri
A K
AK
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001241:Aspirin; D004308:Dothiepin / Q000627:therapeutic use*; D015777:Eicosanoids / Q000502:physiology*; D000431:Ethanol; D007213:Indomethacin; D008026:Ligation; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000929:Antidepressive Agents, Tricyclic; D015777:Eicosanoids; D000431:Ethanol; D001241:Aspirin; D004308:Dothiepin; D007213:Indomethacin