title: Dose-volume effect in gamma knife radiosurgery of meningiomas.
abstract: OBJECTIVE
  To study the relationship between dose-volume effect and complication in gamma knife radiosurgery of intracranial meningiomas.
  
  
  METHODS
  By using an integrated logistic formula to establish mathematical models, the authors analyzed the relationship between treatment volume and logistic probability for 15 Gy, and the relationship between prescribed dose and treatment volume in 3% logistic probability. Furthermore, 37 meningiomas treated by gamma knife radiosurgery were analyzed retrospectively to investigate how the 3% isoeffect curve impacted on complication.
  
  
  RESULTS
  There was a linear relation between treatment volume and logistic probability for 15 Gy. The regression formula was f(x) = 0.0042x + 0.0007. The 3% isoeffect curve indicated that the prescribed dose was inversely proportional to the treatment volume. During 16.3 months follow-up on average, 18 cases below the 3% isodose curve were without complication, but in 19 cases above the 3% isodose curve, 5 cases suffered complications, the difference being statistically significant.
  
  
  CONCLUSIONS
  Dose selection in gamma knife radiosurgery is volume dependent. The 3% isodose curve may possibly be the guideline in gamma knife radiosurgery of meningiomas.
authors.affiliation: Gamma Knife Center, Department of Neurosurgery, Second Hospital of Tianjin Medical University, PRC. tjmushgk@tjuc.com.cn
authors.forename: C S
authors.initials: CS
authors.lastname: Kang
authors.forename: L G
authors.initials: LG
authors.lastname: Zheng
authors.forename: D S
authors.initials: DS
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D008579:Meningioma / Q000175:diagnosis* / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications; D011874:Radiometry; D016634:Radiosurgery / Q000379:methods*; D014057:Tomography, X-Ray Computed