title: Combined colposcopy, loop conization, and laser vaporization reduces recurrent abnormal cytology and residual disease in cervical dysplasia.
abstract: OBJECTIVE
  Loop electrosurgical excision of the transformation zone (LEETZ) was recently associated with relatively high failure rates. We evaluated whether the combination of LEETZ with laser vaporization is superior to LEETZ alone in reducing the rates of recurrent abnormal cytology and residual disease.
  
  
  METHODS
  The study population included 426 women with histologic diagnosis of cervical intraepithelial neoplasia (CIN) 2-3, of whom 289 (study group) were treated by LEETZ followed by laser vaporization of the crater base and walls and 137 (control group) were treated by LEETZ alone. All women were followed scrupulously at regular intervals for recurrent abnormal cytology and residual disease. The mean follow-up periods were 43 and 59 months for the study and control groups, respectively.
  
  
  RESULTS
  Both groups were derived from the same community and were similar in epidemiologic characteristics and disease severity. Although the incidence of positive surgical margins was similar in both groups (10.4 and 9.5% for the study and control groups, respectively), recurrent abnormal cytology (10.2% vs 5.5%, P = 0.07) and histologic residual disease (21.4% vs 0%, P = 0.05) were more frequent among women in the control group. This applied to women with both negative and positive surgical margins. Both study and control women with positive surgical margins, especially at the endocervix, were at higher risk for recurrence.
  
  
  CONCLUSIONS
  The addition of laser vaporization to LEETZ may improve outcome of both women with positive margins and women with negative margins. Our results support conservative management for all treated women, regardless of cone margin status.
authors.affiliation: Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel. danzv@green.co.il
authors.forename: A
authors.initials: A
authors.lastname: Bar-Am
authors.forename: Y
authors.initials: Y
authors.lastname: Daniel
authors.forename: I G
authors.initials: IG
authors.lastname: Ron
authors.forename: J
authors.initials: J
authors.lastname: Niv
authors.forename: M J
authors.initials: MJ
authors.lastname: Kupferminc
authors.forename: J
authors.initials: J
authors.lastname: Bornstein
authors.forename: J B
authors.initials: JB
authors.lastname: Lessing
mesh_terms: D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D015331:Cohort Studies; D003127:Colposcopy; D004598:Electrosurgery / Q000379:methods*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008875:Middle Aged; D018365:Neoplasm, Residual; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery