title: Bronchial granular cell tumor with osteopontin and osteonectin expression: a case report.
abstract: The case of a 52-year-old Japanese man with bronchial granular cell tumors with osteopontin and osteonectin expression is reported here because there have been few investigations of their expression in benign tumors. He was admitted because of sudden hematemesis. A bronchoscopic examination revealed a lobulated polypoid tumor located in the left and right bronchi. Histologically, most tumor cells had abundant granular eosinophilic cytoplasm and were immunoreactive for S-100, neuron-specific enolase (NSE), CD68 and vimentin. Moreover, osteopontin-positive tumor cells were randomly distributed in the tumor tissue, but few stromal cells were positive. In contrast, osteonectin was mainly expressed in the peripheral tumor cells and was also distributed in the stromal cells. Blood vessels at the tumor border in which osteonectin-positive tumor cells were distributed, proliferated moderately. These results suggest that osteopontin and osteonectin may play a role in the progression of granular cell tumors and in the interaction between the tumor and host or angiogenesis around the tumor, respectively.
authors.affiliation: First Department of Pathology, Kochi Medical School, Nankoku City, Kochi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: N
authors.initials: N
authors.lastname: Kuroda
authors.forename: S
authors.initials: S
authors.lastname: Kakiuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: E
authors.initials: E
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Toi
authors.forename: K
authors.initials: K
authors.lastname: Naruse
authors.forename: M
authors.initials: M
authors.lastname: Hiroi
authors.forename: H
authors.initials: H
authors.lastname: Enzan
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001984:Bronchial Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D003593:Cytoplasm / Q000648:ultrastructure; D016586:Granular Cell Tumor / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D006396:Hematemesis / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D015676:Osteonectin / Q000378:metabolism*; D053495:Osteopontin; D012795:Sialoglycoproteins / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D015676:Osteonectin; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin