title: Diabetes and hypertension physiopathology and therapeutics.
abstract: Diabetes mellitus by itself, is a frequent and increasing public health problem. The prevalence in most Western countries varies between 2 to 5% and it is rapidly increasing in Asiatic countries due to changes in dietary habits during the last years. The association between diabetes mellitus and hypertension has been described in 60 to 65% of diabetics. In hypertension we find insulin resistance mainly in skeletal muscle involving the conversion of glucose to glycogen independently of blood flow. The degree of resistance is related to the severity of hypertension and varies between races. States of hyperinsulinaemia and insulin-resistance have been postulated as causes and/or consequences of hypertension. Regardless of the type of diabetes, hypertension is two to three times more common among diabetics compared with non-diabetics. In this paper we propose to review the essential physiopathological mechanisms involved in this association that causes high morbidity and mortality rates and increases disability among the population involved.
authors.affiliation: Faculty of Medicine, Central University of Venezuela.
authors.forename: F
authors.initials: F
authors.lastname: Contreras
authors.forename: M
authors.initials: M
authors.lastname: Rivera
authors.forename: J
authors.initials: J
authors.lastname: Vasquez
authors.forename: M A
authors.initials: MA
authors.lastname: De la Parte
authors.forename: M
authors.initials: M
authors.lastname: Velasco
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D003927:Diet, Diabetic; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D014943:Global Health; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D015995:Prevalence; D015996:Survival Rate
chemical_list: D000959:Antihypertensive Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin