Adenovirus late gene expression does not require a Rev-like nuclear RNA export pathway.
Adenovirus late mRNA export is facilitated by viral early proteins of 55 and 34 kDa. The 34-kDa protein contains a leucine-rich nuclear export signal (NES) similar to that of the human immunodeficiency virus Rev protein. It was proposed that the 34-kDa protein might facilitate the export of adenovirus late mRNA through a Rev-like NES-mediated export pathway. We have tested the role of NES-mediated RNA export during adenovirus infection, and we find that it is not essential for the expression of adenovirus late genes.
Rabino
C
C
Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.
Aspegren
A
A
Corbin-Lickfett
K
K
Bridge
E
E
D000256:Adenoviridae / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D002459:Cell Fusion; D002467:Cell Nucleus / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D015694:Gene Products, rev / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D028884:Karyopherins; D009154:Mutation; D009687:Nuclear Proteins / Q000378:metabolism; D019384:Nucleic Acid Synthesis Inhibitors / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000494:pharmacology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012367:RNA, Viral / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D013501:Surface-Active Agents / Q000494:pharmacology; D014158:Transcription, Genetic; D000097606:Exportin 1 Protein
D002352:Carrier Proteins; D003513:Cycloheximide; D003609:Dactinomycin; D005231:Fatty Acids, Unsaturated; D015694:Gene Products, rev; D028884:Karyopherins; D009687:Nuclear Proteins; D019384:Nucleic Acid Synthesis Inhibitors; D011092:Polyethylene Glycols; D011500:Protein Synthesis Inhibitors; D012367:RNA, Viral; D018160:Receptors, Cytoplasmic and Nuclear; D013501:Surface-Active Agents; D000097606:Exportin 1 Protein; C038753:leptomycin B