Elevated plasma levels of interleukin-1 receptor antagonist are associated with decreased cellular BCL-2 oncoprotein expression in B-chronic lymphocytic leukemia.
Plasma IL-1Ra levels and cellular BCL-2 oncoprotein expression were measured in a total of forty blood samples obtained from twenty-eight B-CLL patients and four healthy subjects. High IL-1Ra plasma levels (as defined by mean + three times standard deviation of normal controls) were observed in eleven samples (ten patients) which showed a significantly decreased cellular expression of BCL-2 protein (14.7 +/- 16.3% of cells as determined by immunofluorescence) when compared to B-CLL samples with no elevated IL-1Ra (BCL-2, 31.0 +/- 18.6%; p < or = 0.0115). Albeit correlational only, our results may encourage further experiments to elucidate potential regulatory effects of IL-1Ra for cellular BCL-2 oncoprotein expression.
Duensing
S
S
Department of Hematology and Oncology, Hannover University Medical Center, Germany.
Nasarek
A
A
Grosse
J
J
Ganser
A
A
Atzpodien
J
J
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood*; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D012016:Reference Values; D012795:Sialoglycoproteins / Q000097:blood*
D014408:Biomarkers, Tumor; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins