title: [The effect of immunotherapy with the VP-4 multicomponent vaccine in children with frequent acute respiratory diseases and obstructive bronchitis].
abstract: The results of prolonged observations on children with frequent acute respiratory diseases (ARD), subject to immunoprophylaxis with the use of polycomponent vaccine (VP-4), prepared from the antigens of opportunistic microorganisms, are presented. The vaccine was introduced to 30 children in 3 intranasal administrations and 6-8 oral administrations. The morbidity rate of the children was registered and their clinical status was evaluated for a year after the introduction of vaccine VP-4. As revealed in these observations, the frequency of ARD cases among the immunized children decreased 3 times or more in comparison with that among the same children, registered during a year prior to the introduction of the vaccine. In addition to a decrease in the frequency of ARD cases, a decrease in their duration and in the number of antibiotic administrations, as well as in the necessity of hospitalization, were also registered.
authors.affiliation: District Children's Hospital, Ramenskoe, Moscow Region, Russia.
authors.forename: N M
authors.initials: NM
authors.lastname: Obol'skaia
mesh_terms: D000208:Acute Disease; D001249:Asthma / Q000209:etiology / Q000276:immunology / Q000628:therapy; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D001991:Bronchitis / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007167:Immunotherapy / Q000379:methods*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000150:complications / Q000276:immunology / Q000628:therapy*; D013997:Time Factors; D017778:Vaccines, Combined / Q000627:therapeutic use
chemical_list: D001428:Bacterial Vaccines; C088865:VP-4 vaccine; D017778:Vaccines, Combined; D007073:Immunoglobulin E
vernacular_title: Effekt immunoterapii polikomponentnoĭ vaktsinoĭ VP-4 u deteĭ s chastymi ostrymi respiratornymi zabolevaniiami i obstruktivnym bronkhitom.