Design and synthesis of AB(3)-type (A = 1,3,5-benzenetricarbonyl unit; B = Glu diOME or Glu(7) octa OMe) peptide dendrimers: crystal structure of the first generation.
The first generation molecule of glutamic acid-based dendrons on a 1, 3,5-benzenetricarbonyl core leads to a cylindrical assembly as demonstrated by single crystal x-ray diffraction. The benzene pi-pi stack (A) is stabilized by vertical NH...O===C hydrogen bonding with each subunit participating in three intermolecular hydrogen bonds related by three-fold rotation symmetry.
Ranganathan
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Discovery Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India.ranganathan@iict.ap.nic.in
Kurur
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Gilardi
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Karle
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IL
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D015195:Drug Design; D018698:Glutamic Acid / Q000737:chemistry; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*
D001555:Benzene Derivatives; D009842:Oligopeptides; D018698:Glutamic Acid