Increased tumor necrosis factor and interleukin-6 production in the central nervous system of interleukin-10-deficient mice.
Interleukin-10 (IL-10) inhibits tumor necrosis factor (TNF) production. We investigated the role of endogenous IL-10 in brain TNF production. We injected IL-10-knockout mice with lipopolysaccharide (LPS,2.5 microg/mouse i.c.v.). Brain TNF and IL-6 levels were more elevated and persisted longer in IL-10-deficient mice compared with wild type mice, suggesting that IL-10 is an important negative feedback inhibitor of TNF and IL-6 production in the CNS.
Agnello
D
D
Istituto di Ricerche Farmacologiche, "Mario Negri", Laboratory of Neuroimmunology, via Eritrea 62, 20157, Milan, Italy.
Villa
P
P
Ghezzi
P
P
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism*; D016753:Interleukin-10 / Q000172:deficiency*; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10