title: Late results with bioprosthetic valves in the elderly.
abstract: OBJECTIVE
  We report the long-term outcome of aortic and mitral bioprostheses in patients over 65 years of age at the time of implantation. The aim was to determine actuarial patient survival, causes of death, and the rate of documented primary structural deterioration.
  
  
  METHODS
  One hundred ten patients > or = 65 years of age (mean, 73.4; range, 65-82) underwent successful bioprosthetic valve replacement (aortic, n = 71; mitral, n = 32; both, n = 7) from 1979 to 1985. The valve was pericardial in 39 cases and porcine in 78. The mean follow-up was 8.5 years (101.9 months-total; 934 patient-years; range, 2 months to 15 years).
  
  
  RESULTS
  Actuarial patient survival was 79.6% (71-86) at 5 years and 62.4% (52-71) at 10 years. Forty-four patients died, 21 from valve-related causes and 23 from other causes. Thirteen patients (11.8%) had reoperation for valve-related complications: 10 structural deteriorations, 2 paravalvular leaks, and 1 case of endocarditis. One surgical death occurred (7.7%). Twenty-six percent of the patients were receiving anticoagulants because of atrial fibrillation, and 6.4% developed severe bleeding (2.9% patient-years).
  
  
  CONCLUSIONS
  Long-term follow-up of these patients > 65 years of age, undergoing bioprosthetic value replacement surgery revealed a low rate of documented primary structural deterioration (0.95% per patient-year), a low mortality rate on reoperation (7.7%), and a high mortality rate due to non-value-related causes (52.3%).
authors.affiliation: Clinique Cardiologique, Hôpital Necker, Paris, France. helftg01@doc.mssm.edu
authors.forename: G
authors.initials: G
authors.lastname: Helft
authors.forename: X
authors.initials: X
authors.lastname: Tabone
authors.forename: J L
authors.initials: JL
authors.lastname: Georges
authors.forename: E
authors.initials: E
authors.lastname: Lomama
authors.forename: C
authors.initials: C
authors.lastname: Lepailleur
authors.forename: C
authors.initials: C
authors.lastname: Le Feuvre
authors.forename: J P
authors.initials: JP
authors.lastname: Metzger
authors.forename: A
authors.initials: A
authors.lastname: Heulin
authors.forename: A
authors.initials: A
authors.lastname: Vacheron
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve; D001022:Aortic Valve Insufficiency / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000601:surgery; D001705:Bioprosthesis; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve; D008944:Mitral Valve Insufficiency / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000601:surgery; D016896:Treatment Outcome