title: Clinicopathological correlation of diaphragmatic contraction band necrosis in a neonatal and infantile population--an autopsy study.
abstract: Contraction band necrosis' is a lesion widely studied in myocardial fibres (Heart) and to some extent in skeletal and smooth muscles. The phenomenon of Diaphragmatic Contraction Band necrosis (D-CBN) occurring in the diaphragms of 53 neonates and infants removed at autopsy were studied microscopically. Of these D-CBN was present in 19 (35.85%) cases. D-CBN presented in two morphological patterns (I) solid ('Block-like') segmental necrosis in 31.58% cases or (ii) Ribbon-like transfiber (shredded appearance) bands in 15.79% cases. A combination of both the above lesions were observed in a vast majority of cases, i.e. 52.63% cases. A clinicopathological correlation was attempted as regards cause and mode of death with occurrence and severity of D-CBN. It was found that severe D-CBN was present in the group of birth asphyxia (26.92%) and infant infections (20.0%). The presence and frequency of D-CBN in autopsied subjects proved useful in interpreting the cause and mode of death.
authors.affiliation: Department of Pathology, B.J. Medical College, Pune.
authors.forename: S
authors.initials: S
authors.lastname: Deshmukh
authors.forename: R
authors.initials: R
authors.lastname: Rao
authors.forename: A
authors.initials: A
authors.lastname: Harke
mesh_terms: D001344:Autopsy; D002423:Cause of Death; D003964:Diaphragm / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009119:Muscle Contraction; D009336:Necrosis