Stimulation of cell invasion and migration by alcohol in breast cancer cells.
Increasing epidemiological studies suggest that alcohol consumption confers a high risk for development of breast cancer. In this study, we found that biologically relevant concentrations of alcohol elicited a significant stimulation of cell adhesion, migration, and invasion in MCF-7 human breast cancer cells. Moreover, the promotion of invasion and migration potential by alcohol was associated with the significant decrease of E-cadherin, alpha, beta, and gamma three major catenin, and BRCA1 expression. In addition, an enhanced expression of BRCA1 significantly blocked alcohol-stimulated cell invasion. Thus, our present study suggests that alcohol as a breast cancer risk factor plays an important role not only in carcinogenesis, but also in promotion of cell invasion and migration.
Meng
Q
Q
Laboratory of Molecular Oncology, Long Island Jewish Medical Center (The Long Island Campus for the Albert Einstein College of Medicine), New Hyde Park, New York 11042, USA.
Gao
B
B
Goldberg
I D
ID
Rosen
E M
EM
Fan
S
S
D000428:Alcohol Drinking; D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D015820:Cadherins / Q000235:genetics; D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D003598:Cytoskeletal Proteins / Q000235:genetics; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D015870:Gene Expression; D019398:Genes, BRCA1; D006801:Humans; D009361:Neoplasm Invasiveness; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D014407:Tumor Cells, Cultured
D015820:Cadherins; D003598:Cytoskeletal Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D000431:Ethanol