title: Dye-enhanced selective laser ablation for surgical mucosectomy.
abstract: The diode laser operates at a wavelength of 805 nm; indocyanine green (ICG) has a maximum energy absorption of a wavelength of approximately 800 nm. The effect of the diode laser as a laser knife can be significantly enhanced with an injection of ICG. In the present study, this dye-enhanced photothermal effect was investigated in the field of surgical endoscopy. A 9-cm2 region of the canine gastric mucosa was removed by the laser after injection of 5 ml of ICG solution at a concentration of 0.5 mg/mL into the submucosal space. The diode laser was used at a power output of 10 watts. The canine stomach was removed 10 days after the operation to investigate the site histologically. Clinical application using transanal endoscopic microsurgery (TEM) was employed using a dye-enhanced laser in five patients with a rectal adenoma. The pathological changes in the canine gastric wall resected 10 days after the operation showed that the low-power laser enhanced by ICG produced less fibrosis in the submucosal space than electrocautery. Mucosal resection using a dye-enhanced laser was easily performed in these five patients. It was concluded that this easy removal of the mucosa by a dye-enhanced laser was due to its ability to produce hemostasis of the vessels and its excellent tissue-cutting effect.
authors.affiliation: Second Department of Surgery, Fukuoka University, Faculty of Medicine, Fukuoka City, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Maekawa
authors.forename: T
authors.initials: T
authors.lastname: Shirakusa
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000601:surgery*; D000818:Animals; D004396:Coloring Agents; D004195:Disease Models, Animal; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004564:Electrocoagulation / Q000379:methods*; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007208:Indocyanine Green; D007413:Intestinal Mucosa / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods*; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green