Heterogeneity in Paget disease of the bone.
Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity.
Nance
M A
MA
Park Nicollet Clinic and Department of Neurology, Hennepin County Medical Center, Minneapolis, MN, USA.
Nuttall
F Q
FQ
Econs
M J
MJ
Lyles
K W
KW
Viles
K D
KD
Vance
J M
JM
Pericak-Vance
M A
MA
Speer
M C
MC
D000328:Adult; D000368:Aged; D002887:Chromosomes, Human, Pair 18; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000235:genetics*; D010375:Pedigree