Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature.
A 66-year-old woman treated for ocular myasthenia gravis with azathioprine for 12 years presented with a left fronto-parietal mass. Histology revealed primary Hodgkin's lymphoma of the central nervous system with CD30, Epstein-Barr virus (EBV) latent membrane protein and CD20-positive, CD45 (LCA)-negative Reed-Sternberg cells surrounded by T cells. Moreover, EBV-encoded RNA-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy chain CDR2 locus were detected.
Herrlinger
U
U
Department of Neurology, University of Tübingen, Germany. ulrich.herrlinger@uni-tuebingen.de
Klingel
K
K
Meyermann
R
R
Kandolf
R
R
Kaiserling
E
E
Kortmann
R D
RD
Melms
A
A
Skalej
M
M
Dichgans
J
J
Weller
M
M
D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D011859:Radiography; D016896:Treatment Outcome