title: Caffeine induces in vivo premature appearance of telencephalic vesicles.
abstract: Caffeine administered to pregnant mice during germinative neuroepithelium preparation (embryonic days 8-10) dramatically accelerated primitive neuroepithelium evagination into telencephalic vesicles, versus age-matched controls. This histologically-documented, dose-dependent effect seemed reversible during subsequent neuronal migration if caffeine exposure was discontinued. Our in vivo model provides a new tool for studying telencephalic symmetry acquisition and for identifying genes potentially involved in holoprosencephaly, a developmental disorder characterized by defective telencephalic vesicle formation.
authors.affiliation: Service de Neurologie Pédiatrique, Hôpital Robert-Debré, 48 Blvd. Sérurier, 75019, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Sahir
authors.forename: N
authors.initials: N
authors.lastname: Bahi
authors.forename: P
authors.initials: P
authors.lastname: Evrard
authors.forename: P
authors.initials: P
authors.lastname: Gressens
mesh_terms: D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D016142:Holoprosencephaly / Q000139:chemically induced*; D051379:Mice; D011247:Pregnancy; D013687:Telencephalon / Q000187:drug effects* / Q000196:embryology*
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine