Leptin-induced decrease in food intake in chickens.
The effect of intracerebroventricular (i.c.v.) injection of leptin was investigated using broiler and Single Comb White Leghorn (SCWL)-type chickens. These represent relatively fast- and slow-growing birds, respectively. The i.c.v. injection of leptin decreased food intake in both broilers and Leghorns in a dose-dependent manner. The most efficacious dose appeared to be 10 microg in both types of chickens. Water intake was generally not affected by leptin, indicating that this effect was not due to general malaise. It appears that leptin can act within the central nervous sytstem of birds to decrease food intake.
Denbow
D M
DM
Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0306, USA. denbowdm@vt.edu
Meade
S
S
Robertson
A
A
McMurtry
J P
JP
Richards
M
M
Ashwell
C
C
D000375:Aging / Q000502:physiology; D000818:Animals; D002645:Chickens / Q000502:physiology*; D003864:Depression, Chemical; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D006128:Growth / Q000502:physiology; D006801:Humans; D007276:Injections, Intraventricular; D020738:Leptin / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology
D020738:Leptin; D011994:Recombinant Proteins