Intermolecular accessibility: the meaning of molecular connectivity
The molecular connectivity indices are shown to be the numerical possibilities of a molecule encountering another identical molecule, derived from the bond accessibilites of each. The meaning of the delta values and the significance of all suppressed X-H bonds is described. A new concept of the meaning of molecular connectivity, built around bimolecular encounter accessibility, is presented.
Kier
LB
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond 23298, USA.
Hall
LH