title: Bacterial nosocomial pneumonia in Paediatric Intensive Care Unit.
abstract: OBJECTIVE
  To determine the incidence, risk factors, mortality and organisms causing nosocomial pneumonia (NP) in intubated patients in Paediatric Intensive Care Unit (PICU).
  
  
  METHODS
  All patients with endotracheal (ET) tube with or without mechanical ventilation (MV) in a PICU of a tertiary care teaching hospital were included in this prospective study. Clinical parameters and investigations were evaluated in patients who developed nosocomial pneumonia (NP). Colonisation of the ET tube tip was studied by culture and the antibiotic susceptibility pattern of the isolates was determined.
  
  
  RESULTS
  Sixty-nine patients had an ET tube inserted and fifty-nine of these underwent MV. ET tube tip colonisation was seen in 70 out of 88 ET tubes inserted. The incidence of NP in patients with ET tube was 27.54% (7.96/100 days of ET intubation). NP developed only in patients undergoing MV. The main risk factors for developing NP were - duration of MV and duration of stay in the PICU. Age, sex, immunocompromised status and altered sensorium did not increase the risk of NP. The mortality in cases with NP was 47. 37%. E. coli and Klebsiella were the commonest organisms isolated from the ET tube tip cultures with maximum susceptibility to amikacin and cefotaxime.
  
  
  CONCLUSIONS
  NP developed only in patients undergoing MV. Duration of MV and duration of stay in the PICU increased the risk of developing NP.
authors.affiliation: Department of Paediatrics,Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai - 400 012, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Tullu
authors.forename: C T
authors.initials: CT
authors.lastname: Deshmukh
authors.forename: S M
authors.initials: SM
authors.lastname: Baveja
mesh_terms: D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000209:etiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D015278:Intensive Care Units, Pediatric; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D007902:Length of Stay; D008297:Male; D008826:Microbial Sensitivity Tests; D011014:Pneumonia / Q000209:etiology*; D011336:Probability; D012121:Respiration, Artificial / Q000009:adverse effects*; D012307:Risk Factors; D013997:Time Factors