Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties.
The synthesis of new N-(4-pyridyl)-1-aminopyrazoles is described. Their binding properties were tested for muscarinic and other neurotransmitter receptors, together with their acetylcholinesterase inhibitory activity. The series derived from 3,5-dimethyl-1H-pyrazole showed moderate activities in both muscarinic and adrenergic receptor binding tests.
Rodríguez-Franco
M I
MI
Instituto de Química Médica (C.S.I.C.), Madrid, Spain.
Dorronsoro
I
I
Martínez
A
A
Pérez
C
C
Badía
A
A
Baños
J E
JE
D000110:Acetylcholinesterase / Q000378:metabolism; D000322:Adrenergic Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018721:Muscarinic Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011485:Protein Binding; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D043643:Receptor, Muscarinic M1; D011941:Receptors, Adrenergic / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D000322:Adrenergic Agonists; D004791:Enzyme Inhibitors; D018721:Muscarinic Agonists; D011720:Pyrazoles; D011725:Pyridines; D043643:Receptor, Muscarinic M1; D011941:Receptors, Adrenergic; D011976:Receptors, Muscarinic; D000110:Acetylcholinesterase