title: Anemia as a risk factor of hemorrhagic tendency during surgery.
abstract: OBJECTIVE
  Although it is well-known that a hemorrhagic tendency in patients with massive bleeding during surgery, or with anemia before surgery, is difficult to control, its mechanism is still obscure.
  
  
  METHODS
  Using a damped oscillation rheometer, we measured the initiation time (Ti) of whole blood with several concentrations of red blood cells (RBCs) and the Ti of platelet-free plasma (PFP) with various concentrations of RBCs.
  
  
  RESULTS
  The Ti of the whole blood became prolonged according to the dilution of the RBC concentration. RBCs could coagulate the PFP, and the Ti of PFP also was prolonged according to the dilution of the RBC concentration.
  
  
  CONCLUSIONS
  These results suggest that RBCs might have an important role as a phospholipid supplier in the intrinsic pathway of the blood-coagulation mechanism. Anemia could thus represent a risk factor for hemorrhagic tendency during surgery due to lower RBC concentrations.
authors.affiliation: Department of Obstetrics and Gynecology, Japan Self Defense Forces Central Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sagesaka
authors.forename: H
authors.initials: H
authors.lastname: Juen
authors.forename: M
authors.initials: M
authors.lastname: Kaibara
mesh_terms: D000328:Adult; D000740:Anemia / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D001777:Blood Coagulation / Q000502:physiology*; D016063:Blood Loss, Surgical / Q000503:physiopathology*; D001809:Blood Viscosity; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D018056:Hemorheology; D006801:Humans; D008297:Male; D012016:Reference Values; D012307:Risk Factors