title: [The vaccination of children with severe somatic pathology].
abstract: 1,696 children were vaccinated; of these, 1,487 children had different kinds of somatic pathology, including 1,181 children with CNS lesions, 29 children with malignant tumors, 45 children with congenital defects, 82 children with allergic diseases, etc. The group of relatively healthy vaccinees consisted of 209 children. The following vaccines were used for immunization: Tetracoq 05, D.T.Vax, Rudivax, Imovax Polio, Vaxigrip (Pasteur Mèrieux Connaught, France); HBVax, MMRII (Merck Sharp & Dohme, USA); as well as vaccines against hepatitis B produced by Smith Kline Beecham (UK) and Combiotech (Russia). In no case severe vaccine-associated complications were observed. The frequency and manifestation of reactions in children with somatic pathology did nor essentially differ from those in relatively healthy children. The increase of the number of vaccine components did not lead to the increase of the number of side effects of the severity of their manifestation. These investigations demonstrated the safety of vaccination for children with somatic pathology.
authors.affiliation: Russian State Medical University, Center of Vaccinoprophylaxis Diavaks, Moscow, Russia.
authors.forename: V F
authors.initials: VF
authors.lastname: Uchaĭkin
authors.forename: L O
authors.initials: LO
authors.lastname: Skachkova
authors.forename: O V
authors.initials: OV
authors.lastname: Shamsheva
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.forename: I V
authors.initials: IV
authors.lastname: Polesko
authors.forename: L N
authors.initials: LN
authors.lastname: Lezhneva
authors.forename: A M
authors.initials: AM
authors.lastname: Timakov
authors.forename: V G
authors.initials: VG
authors.lastname: Poliakov
authors.forename: I E
authors.initials: IE
authors.lastname: Gavrilova
authors.forename: S G
authors.initials: SG
authors.lastname: Gubanova
mesh_terms: D002648:Child; D003140:Communicable Disease Control / Q000706:statistics & numerical data; D015897:Comorbidity; D006801:Humans; D012426:Russia; D014611:Vaccination / Q000009:adverse effects / Q000706:statistics & numerical data; D014612:Vaccines / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D014612:Vaccines
vernacular_title: Vaktsinatsiia deteĭ s tiazheloĭ somaticheskoĭ patologieĭ.