Voltammetric methods for analytical determination of fleroxacin in quinodis tablets.
The direct current (dc) and differential pulse (dp) polarographic reduction of fleroxacin was done in a wide pH range from 2.48 to 13.00. The appropriate buffer choice was made for its dp polarographic determination in a range from 1.845 to 16.926 microg /ml, at pH 8.50. The adsorptive properties of fleroxacin were investigated in order to achieve an increase in sensitivity and a possibility of fleroxacin determination by applying the adsorptive stripping voltammetric method. The adsorptive processes at the hanging mercury drop electrode were investigated in Britton-Robinson and borate buffers. Adsorptive preconcentration followed by differential-pulse cathodic stripping showed one wave at approximately - 1.1 V being the most sensitive for analytical determination of fleroxacin. Two linear ranges were obtained, the first one from 18.465 to 258.51 ng/ml, and the second one from 3.693 to 18.465 ng/ml.
Kapetanović
V
V
Institute of Analytical and Physical Chemistry, Faculty of Pharmacy, University of Belgrade, Yugoslavia. vkapetph@yubc.net
Milovanović
L J
LJ
Aleksić
M
M
Ignjatović
L J
LJ
D000890:Anti-Infective Agents / Q000032:analysis*; D002138:Calibration; D004563:Electrochemistry; D004566:Electrodes; D016576:Fleroxacin / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D011048:Polarography; D013607:Tablets
D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D013607:Tablets; D016576:Fleroxacin