Intravenous pharmacokinetics of ciprofloxacin in goats.
The pharmacokinetics of ciprofloxacin in goats was studied following intravenous administration. A single dose of 10 mg/kg was administered as an intravenous bolus, and serum samples were collected at predetermined intervals over a 24 h period. Ciprofloxacin levels were measured using high pressure liquid chromatography and the resulting concentration versus time curve was analyzed using a non linear regression analysis. The data were best represented by a two-compartment pharmacokinetic model with a mean elimination half-life of 2.72+/-1.04 h. Mean pharmacokinetic parameters obtained were area under the curve (AUC: 10.320+/-5.137 microg/ml per h), mean residence time (MRT: 3.334+/-1.428 h), apparent volume of distribution (Vdss: 3.373+/-0.893 l/kg) and total body drug clearance (tCl 19.596+/-9.059 ml/min per kg). Ciprofloxacin in goats showed the general pharmacokinetic characteristics of a typical fluoroquinolone antibacterial agent and we recommend a dose of 10 mg/kg to be administered intravenously at 12 h intervals to goats.
García Ovando
H
H
Farmacología-Departemento de Clínica Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Ruta 36, km 601, 5800 (Cba), Río Cuarto, Argentina. hgarciaovando@ayv.unrc.edu.ar
Gorla
N
N
Poloni
G
G
Trotti
N
N
Prieto
G
G
Errecalde
C
C
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006041:Goats; D007275:Injections, Intravenous
D000890:Anti-Infective Agents; D002939:Ciprofloxacin