Radiation, radicals, and images.
Nitroxide stable free radicals exhibit varied chemical and biological properties. Their biological applications have been greatly expanded over the past few years. Not only have they been shown to exhibit potent antioxidant and radioprotective properties, but also they can serve as in vivo functional imaging probes that non-invasively report on the oxygen status and redox properties of tissue, which may have utility in clinical biomedical research.
Mitchell
J B
JB
Radiation Biology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA. jbm@helix.nih.gov
Russo
A
A
Kuppusamy
P
P
Krishna
M C
MC
D000818:Animals; D005609:Free Radicals; D006801:Humans; D015335:Molecular Probes; D009589:Nitrogen Oxides / Q000737:chemistry*; D011837:Radiation-Protective Agents / Q000737:chemistry; D011853:Radiobiology
D005609:Free Radicals; D015335:Molecular Probes; D009589:Nitrogen Oxides; D011837:Radiation-Protective Agents