Angiotensin II and the heart : on the intracrine renin-angiotensin system.
-The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under normal and pathological conditions. Finally, we discuss the possibility that there is an intracrine renin-angiotensin system in the heart that plays a role in the control of cell communication and inward Ca(2+) current.
De Mello
W C
WC
Department of Pharmacology, Medical Sciences Campus, University of Puerto Rico, San Juan, PR 00936-5067.
Danser
A H
AH
D000804:Angiotensin II / Q000096:biosynthesis / Q000502:physiology*; D000818:Animals; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000378:metabolism; D006801:Humans; D009206:Myocardium / Q000166:cytology / Q000378:metabolism; D010812:Physical Stimulation; D011945:Receptors, Angiotensin / Q000502:physiology; D012016:Reference Values; D012084:Renin-Angiotensin System / Q000502:physiology*
D011945:Receptors, Angiotensin; D000804:Angiotensin II