title: Pharmacokinetics and penetration of danofloxacin into the gastrointestinal tract in healthy and in Salmonella typhimurium infected pigs.
abstract: The pharmacokinetics and penetration of danofloxacin into the gastrointestinal tract in healthy pigs and in pigs experimentally infected with Salmonella typhimurium were studied. In the infected pigs, a decrease in body clearance and an increase in mean elimination half-life was observed (P < 0.01). Moreover a significant reduction in the volume of the peripheral compartment was found. Danofloxacin distributed well to the gastrointestinal tract achieving high AUC / AUC(plasma)ratios in both groups of pigs. However, compared to the healthy pigs AUC / AUC(plasma)ratios decreased in the infected pigs. Salmonella infection led to an increase in mean residence time (MRT) in the small intestines and lymph nodes and a decrease in MRT in caecum and colon.
authors.affiliation: Department of Pharmacology and Pathobiology, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
authors.forename: R H
authors.initials: RH
authors.lastname: Lindecrona
authors.forename: C
authors.initials: C
authors.lastname: Friis
authors.forename: J P
authors.initials: JP
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D004064:Digestive System / Q000378:metabolism*; D024841:Fluoroquinolones; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D012481:Salmonella Infections, Animal / Q000378:metabolism*; D012486:Salmonella typhimurium; D013552:Swine / Q000378:metabolism*; D013553:Swine Diseases / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C068581:danofloxacin