title: No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.
abstract: We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.
authors.affiliation: Flanders Interuniversity Institute for Biotechnology, Department of Biochemistry, University of Antwerp, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Goossens
authors.forename: S
authors.initials: S
authors.lastname: Villafuerte
authors.forename: F
authors.initials: F
authors.lastname: Tissir
authors.forename: S
authors.initials: S
authors.lastname: Van Gestel
authors.forename: S
authors.initials: S
authors.lastname: Claes
authors.forename: D
authors.initials: D
authors.lastname: Souery
authors.forename: I
authors.initials: I
authors.lastname: Massat
authors.forename: D
authors.initials: D
authors.lastname: Van den Bossche
authors.forename: K
authors.initials: K
authors.lastname: Van Zand
authors.forename: J
authors.initials: J
authors.lastname: Mendlewicz
authors.forename: C
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: J
authors.initials: J
authors.lastname: Del-Favero
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D018911:Trinucleotide Repeats / Q000235:genetics*