Immunocytochemical study of giant cell fibroma.
Giant cell fibroma (GCF) is a non-neoplastic lesion of the oral mucosa. The origin of stellate and multinucleate cells of GCF is not well known. The purpose of the present article was to investigate the immunoreactivity of these cells for leukocyte common antigen, vimentin, tryptase, HLA-DR, alpha-smooth muscle actin, CD68, and S-100. The results showed positive staining only for vimentin. This suggests that the stellate and multinucleate cells of GCF have a fibroblast phenotype.
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Departamento de Cirurgia Buccal e Patologia, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Belo Horzonte, Brasil.
Gomez
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D000199:Actins / Q000032:analysis; D000328:Adult; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D019070:Cell Lineage; D002675:Child, Preschool; D053818:Chymases; D005260:Female; D005347:Fibroblasts / Q000737:chemistry; D005350:Fibroma / Q000737:chemistry / Q000473:pathology*; D015726:Giant Cells / Q000737:chemistry / Q000473:pathology*; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D007124:Immunoenzyme Techniques; D017493:Leukocyte Common Antigens / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000032:analysis; D053802:Tryptases; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
D000199:Actins; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D053818:Chymases; D006684:HLA-DR Antigens; D017493:Leukocyte Common Antigens; D009418:S100 Proteins; D012697:Serine Endopeptidases; D053802:Tryptases; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C083294:chymase 2