title: Global improvement in intellectual and neuropsychological functioning after removal of a suprasellar cystic craniopharyngioma.
abstract: This is a case report of a patient who presented with cognitive and behavioral decline and underwent surgery for removal of a suprasellar craniopharyngioma. Previous studies have reported memory impairments in the presence of craniopharyngioma, but information is lacking regarding the impact of craniopharyngioma on other brain functions as well as on intellectual abilities. In this study, comprehensive neuropsychological testing, including intellectual testing, was conducted 9 to 14 days before surgery and 16 to 22 days after surgery. Results before surgery demonstrated average intellectual abilities, which were decreased from premorbid estimates, and diffuse neuropsychological impairments. Postoperatively, significant improvement in both intellectual abilities and neuropsychological test scores was observed. These results suggest that craniopharyngiomas can be associated with impairments in intellectual abilities and in brain functions aside from memory. The results are contrasted with those of previous reports, and implications for future research are discussed.
authors.affiliation: Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108-1597, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Fitzgerald
authors.forename: E
authors.initials: E
authors.lastname: Morgenstern
mesh_terms: D003072:Cognition Disorders / Q000209:etiology* / Q000601:surgery; D003397:Craniopharyngioma / Q000150:complications / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011581:Psychological Tests; D012920:Social Behavior Disorders / Q000209:etiology* / Q000601:surgery; D016896:Treatment Outcome