title: Hemophagocytic syndrome as an unusual form of presentation of tuberculosis in a hemodialysis patient: case report and review of the literature.
abstract: We present an unusual manifestation of tuberculosis in a patient on hemodialysis. A 73-year-old woman was admitted to our hospital with a picture of fever, dyspnea and weight loss. She had chronic renal failure and had started periodic hemodialysis 5 years before. Fifteen days after admission, she began with pancytopenia, abnormal liver function and coagulopathy. A bone marrow aspiration was made 1 week later showing macrophage elements with phagocytic activity. Eight weeks later, bone marrow culture in Lowenstein media confirmed the presence of tuberculosis. After the beginning of antituberculosis therapy, the laboratory disturbances disappeared and the clinical situation improved. We think that fever of unknown origin and pancytopenia in patients on maintenance hemodialysis must lead to an early bone marrow biopsy or aspiration since after the diagnosis a specific therapy can cure the disease.
authors.affiliation: Division of Nephrology, Department of Medicine, Hospital San Pedro de Alcántara, Cáceres, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Castellano
authors.forename: J R
authors.initials: JR
authors.lastname: Gómez-Martino
authors.forename: T
authors.initials: T
authors.lastname: Hernández
authors.forename: L
authors.initials: L
authors.lastname: Mateos
authors.forename: C
authors.initials: C
authors.lastname: Argüello
mesh_terms: D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D006435:Renal Dialysis; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents