title: [New therapeutic strategies in schizophrenia: apropos of acute decompensation treated with olanzapine].
abstract: Mr B is a 32-year-old patient with a disorganized type of schizophrenia and his treatment, started when he was 20, has always been difficult and his social integration has become progressively worse. In 1998, treatment with olanzapine was started when he suffered acute decompensation on top of his disorganized condition which had an adverse effect on his symptoms. In a short space of time, a very satisfactory improvement was seen, not only in his symptoms but also in his social integration. This improvement has been sustained throughout two and a half years of follow-up. The perspectives offered by the new antipsychotic drugs in the management of acute episodes of schizophrenia are discussed in the light of recent data from the literature and lead to a reconsideration of our therapeutic practices.
authors.affiliation: Centre hospitalier Victor Dupouy, Argenteuil.
authors.forename: A
authors.initials: A
authors.lastname: Portier
authors.forename: J F
authors.initials: JF
authors.lastname: Antonetti
mesh_terms: D000208:Acute Disease; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D012562:Schizophrenia, Disorganized / Q000188:drug therapy*; D012917:Social Adjustment
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine
vernacular_title: Nouvelles stratégies thérapeutiques dans la schizophrénie: à propos d'une décompensation aiguë traitée par olanzapine.