title: Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds.
abstract: This paper concerns the synthesis of various simplified analogues of the novel anti-microbial agent, squalamine. The compounds were then investigated for activity against Trypanosoma brucei, the causative agent of African trypanosomiasis, Trypanosoma cruzi, the causative agent of Chagas disease and Leishmania donovani, the causative agent of visceral leishmaniasis. Several compounds showed in vitro activity, especially against T. brucei and L. donovani. However, one compound showed poor in vivo activity.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, UK.
authors.forename: S
authors.initials: S
authors.lastname: Khabnadideh
authors.forename: C L
authors.initials: CL
authors.lastname: Tan
authors.forename: S L
authors.initials: SL
authors.lastname: Croft
authors.forename: H
authors.initials: H
authors.lastname: Kendrick
authors.forename: V
authors.initials: V
authors.lastname: Yardley
authors.forename: I H
authors.initials: IH
authors.lastname: Gilbert
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002777:Cholestanols / Q000737:chemistry / Q000494:pharmacology; D007893:Leishmania donovani / Q000187:drug effects*; D014346:Trypanosoma brucei brucei / Q000187:drug effects*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D002777:Cholestanols; C079655:squalamine