title: Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase.
abstract: 3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one has been found to be a new, potent, low molecular weight non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase with IC50 value of 30 nM. Preliminary studies suggest that the two carbonyl groups present in the compound are crucial for the inhibition activity.
authors.affiliation: Department of Chemistry, Tunghai Christian University, Taichung, Taiwan, ROC.
authors.forename: S W
authors.initials: SW
authors.lastname: Lin
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
authors.forename: T C
authors.initials: TC
authors.lastname: Lin
authors.forename: D Y
authors.initials: DY
authors.lastname: Yang
mesh_terms: D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007659:Ketones / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D007659:Ketones; D015111:4-Hydroxyphenylpyruvate Dioxygenase