title: Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy.
abstract: OBJECTIVE
  To characterize the risk factors and neuropsychological performance of two subgroups of community-dwelling, white elderly men free of severe cognitive impairment (n = 383; mean age, 72.9 +/- 3.0 years) who differ on volumetric measurements of total brain parenchyma and white matter hyperintensity (WMH) volumes.
  
  
  METHODS
  Group comparisons were made of cerebrovascular disease risk factors measured at the time of imaging and at three prior examinations extending over 25 years of adult life. Measures of verbal memory and speed psychomotor processing at the time of imaging and 10 years before imaging were also available.
  
  
  RESULTS
  Compared with those in the "nonatrophy" group, individuals in the subgroup with "atrophy" (defined by low total brain volume and high WMH volume) were older, reported a higher level of depressive symptomatology, experienced a steeper decline in diastolic blood pressure (DBP) and a steeper increase in pulse pressure, were less physically active, had smoked for more years, and had a higher prevalence of several cardiovascular disease indicators, including an ankle/arm systolic blood pressure ratio less than 0.9, and hypertension. After multivariate analysis, the 25-year decline in DBP, the number of years smoked, and an ankle/arm index of less than 0.9 remained significant discriminators of the two groups. Lower levels of speeded performance at the time of imaging and a steeper 10-year decline in cognitive performance on selected tests were also observed in the atrophic group.
  
  
  CONCLUSIONS
  Community-dwelling older adults with volumetric brain measurements associated with accelerated aging are distinguishable on the basis of several health-related characteristics. These individuals also perform less well on certain tasks involving executive functioning.
authors.affiliation: Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Swan
authors.forename: C
authors.initials: C
authors.lastname: DeCarli
authors.forename: B L
authors.initials: BL
authors.lastname: Miller
authors.forename: T
authors.initials: T
authors.lastname: Reed
authors.forename: P A
authors.initials: PA
authors.lastname: Wolf
authors.forename: D
authors.initials: D
authors.lastname: Carmelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy / Q000150:complications / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000150:complications; D006801:Humans; D008297:Male; D008606:Mental Processes; D008875:Middle Aged; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*