title: Paroxysmal vagal overactivity, apparent life-threatening event and sudden infant death.
abstract: The possibility of reversible cardiac asystoly due to paroxysmal vagal overactivity (VO) has been well studied, first in adults, then in children, and finally in breath-holding spells. Few studies deal with infants and the incidence of VO among preterm, apparent life-threatening event (ALTE) and sudden infant death syndrome (SIDS). In this review, we summarize data acquired during the past 20 years leading to the diagnosis of VO in infants. We describe the clinical aspects of VO in infants and young children such as Holter-ECG and oculocardiac reflex criteria. The familial aspect of VO and its possible link with SIDS (a new risk factor?) are discussed. Finally, whether or not to treat infants with symptomatic VO is discussed.
authors.affiliation: Unité de Rythmologie Pédiatrique, Centre de Cardiologie Infantile du Château des Côtes, Les Loges en Josas, France.
authors.forename: V
authors.initials: V
authors.lastname: Lucet
authors.forename: O
authors.initials: O
authors.lastname: de Bethmann
authors.forename: I
authors.initials: I
authors.lastname: Denjoy
mesh_terms: D002675:Child, Preschool; D004562:Electrocardiography; D006801:Humans; D007223:Infant; D013398:Sudden Infant Death / Q000209:etiology*; D020421:Vagus Nerve Diseases / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000628:therapy