No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder.
We previously identified 18q21.33-q23 as a candidate region in one BP family and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolated four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentation, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repeats located in the 18q21.33-q23 BP candidate region showed no expanded alleles in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.
Goossens
D
D
Flanders Interuniversity Institute for Biotechnology, Department of Biochemistry, University of Antwerp, Belgium.
Villafuerte
S
S
Tissir
F
F
Van Gestel
S
S
Claes
S
S
Souery
D
D
Massat
I
I
Van den Bossche
D
D
Van Zand
K
K
Mendlewicz
J
J
Van Broeckhoven
C
C
Del-Favero
J
J
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002887:Chromosomes, Human, Pair 18; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D018911:Trinucleotide Repeats / Q000235:genetics*