[Levels of Cd, Pb in blood and Zn, Cu, Cd, Pb in amniotic fluid of tobacco smoking women during pregnancy complicated oligohydramnios or premature rupture of membranes].
OBJECTIVE
The ingredients of tobacco smoke have the impact on uterine blood vessels. They caused vascular insufficiency of placenta during development of gestation and changes in placental tissue and fetal membranes. It manifest changeable metal permeability and others symptoms.


METHODS
Assessment of metal contents in blood and amniotic fluid in pregnancies with oligohydramnios and PROM.


METHODS
The materials for studies were blood and amniotic fluid of 30 pregnancies. All of them had made amino-punction between 20 and 38 week of pregnancy before procedure of amniotic fluid supplementation. 15 patients had diagnosed oligohydramnios and the next 15 women had diagnosed premature rupture of membranes. Metals were determined by method of electrothermal atomical absorbic spectrophotometry (ET-ASA).


CONCLUSIONS
Twice lower concentration of Zn and Cd and ten times lower concentration of Pb in amniotic fluids in examined women than women in normal pregnancy were observed. The women, with oligohydramnios in earlier period of gestation, smoked many more cigarettes and cotinine++ and Cd. were much higher. Both these facts had relevance with each other certainly. The stillborns were many more in this group. The different distribution of Cd, Pb, Zn in pregnant women with PROM and oligohydramnios, comparing with women in normal pregnancy was demonstrated. It is probable to be effect of placental tissue and fetal membranes disfunction.
Milnerowicz
H
H
Katedry i Zakładu Toksykologii AM we Wrocławiu.
Zalewski
J
J
Geneja
R
R
Milnerowicz-Nabzdyk
E
E
Woytoń
J
J
D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry*; D002104:Cadmium / Q000097:blood*; D003300:Copper / Q000032:analysis*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D007854:Lead / Q000097:blood*; D008875:Middle Aged; D016104:Oligohydramnios / Q000097:blood* / Q000175:diagnosis*; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011248:Pregnancy Complications; D015032:Zinc / Q000032:analysis*
D002104:Cadmium; D007854:Lead; D003300:Copper; D015032:Zinc
Poziom metali Cd i Pb we krwi oraz Zn, Cu, Cd i Pb w wodach płodowych kobiet palacych papierosy podczas ciazy powikłanej małowodziem lub przedwczesnym odpływaniem wód płodowych.