Messenger proteins: homeoproteins, TAT and others.
Some proteins are internalized by live cells by a process that does not involve classical endocytosis and thus gain direct access to the cytoplasm and nucleus. These same proteins are often secreted, despite the absence of a signal peptide. Recent studies of this unexpected mode of intercellular signaling have opened the way for biotechnological developments.
Prochiantz
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CNRS UMR 8542, Ecole Normale Supérieure, Paris Cedex 5, 75230, France. prochain@wotan.ens.fr.
D000595:Amino Acid Sequence; D015696:Gene Products, tat / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D015398:Signal Transduction
D015696:Gene Products, tat; D018398:Homeodomain Proteins