title: 5-Thienyltryptamine derivatives as serotonin 5-HT1B/1D receptor agonists: potential treatments for migraine.
abstract: A series of 5-(2- or 3-thienyl)tryptamine derivatives (9) has been synthesized and shown to be potent and selective 5-HT1D versus 5-HT1B receptor agonists and, therefore, potential treatments for migraine.
authors.affiliation: NPS Allelix Corp., Mississauga, Ontario, Canada. cmeng@atherogenics.com
authors.forename: C Q
authors.initials: CQ
authors.lastname: Meng
authors.forename: S
authors.initials: S
authors.lastname: Rakhit
authors.forename: D K
authors.initials: DK
authors.lastname: Lee
authors.forename: R
authors.initials: R
authors.lastname: Kamboj
authors.forename: K L
authors.initials: KL
authors.lastname: McCallum
authors.forename: L
authors.initials: L
authors.lastname: Mazzocco
authors.forename: K
authors.initials: K
authors.lastname: Dyne
authors.forename: A
authors.initials: A
authors.lastname: Slassi
mesh_terms: D003001:Cloning, Molecular; D006801:Humans; D007202:Indicators and Reagents; D008881:Migraine Disorders / Q000188:drug therapy*; D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014363:Tryptamines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: C470302:HTR1B protein, human; D007202:Indicators and Reagents; D044302:Receptor, Serotonin, 5-HT1B; D044346:Receptor, Serotonin, 5-HT1D; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D014363:Tryptamines