title: Deposition of calcium pyrophosphate in tissue after revision arthroplasty of the hip.
abstract: We reviewed histologically the incidence and pathogenesis of the deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the pseudocapsule, femoral and acetabular membranes and periprosthetic tissue at revision of 789 cases of failed total hip replacement. In 13, periprosthetic tissues were found to have deposits of CPPD crystals in areas of cartilaginous metaplasia; four also showed evidence of localised deposition of amyloid. None of the patients had a history of chondrocalcinosis in the hip or other joints. Cartilaginous metaplasia and other changes in periprosthetic tissues may predispose to the deposition of CPPD and associated localised amyloid.
authors.affiliation: Nuffield Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Headington, Oxford, UK.
authors.forename: R
authors.initials: R
authors.lastname: Crawford
authors.forename: B
authors.initials: B
authors.lastname: Puddle
authors.forename: N
authors.initials: N
authors.lastname: Hunt
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
mesh_terms: D000077:Acetabulum / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000032:analysis; D019644:Arthroplasty, Replacement, Hip; D002131:Calcium Pyrophosphate / Q000032:analysis*; D003238:Connective Tissue / Q000473:pathology*; D003460:Crystallization; D019544:Equipment Failure Analysis; D005260:Female; D005269:Femur / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012086:Reoperation
chemical_list: D000682:Amyloid; D002131:Calcium Pyrophosphate