title: The management of adult aggressive non-Hodgkin's lymphomas.
abstract: Aggressive non-Hodgkin's lymphona include diffuse large B-cell lymphoma, anaplastic large cell lymphona, and different peripheral T-cell lymphomas. An international prognostic index has been developed including age, serum LDH, performance status, and extranodal involvement. For localized aggressive lymphoma, the preferred treatment is 3-4 CHOP and radiation therapy, with a cure rate of 70-80%. For disseminated aggressive lymphoma, current regimens have a cure rate of less than 40%. Innovative strategies, including dose escalation, autologus stem cell support, new drugs, and immunotherapy are being explored to improve these results.
authors.affiliation: Groupe de Radiothérapie et d'Oncologie médicale des Pyrénées (GROP), chemin de l'Ormeau, 65000, Tarbes, France.
authors.forename: B
authors.initials: B
authors.lastname: Couderc
authors.forename: J P
authors.initials: JP
authors.lastname: Dujols
authors.forename: F
authors.initials: F
authors.lastname: Mokhtari
authors.forename: J L
authors.initials: JL
authors.lastname: Norkowski
authors.forename: J C
authors.initials: JC
authors.lastname: Slawinski
authors.forename: D
authors.initials: D
authors.lastname: Schlaifer
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D016879:Salvage Therapy