Similar 9-year mortality risks and reproducibility for the World Health Organization and American Diabetes Association glucose tolerance categories: the Hoorn Study.
OBJECTIVE
To compare the risks of all-cause and cardiovascular disease (CVD) mortality in the American Diabetes Association (ADA) and World Health Organization (WHO) glucose tolerance categories after 9 years of follow-up in the Hoorn Study and to study the test-retest reproducibility of those categories.


METHODS
In this population-based cohort study of 2,468 elderly men and women, subjects were classified according to both the WHO and the ADA criteria. Causes of death were extracted from the medical records. Age- and sex-adjusted relative risks were estimated by Cox's proportional hazards model. Reproducibility of the diagnostic criteria was assessed in a sample of 1,109 subjects with duplicate oral glucose tolerance tests.


RESULTS
Subjects with known diabetes had a four to five times higher risk of all-cause and CVD mortality compared with normal subjects (P<0.05). The relative risks of all-cause mortality were 1.67 (95% CI 1.09-2.57) and 1.56 (1.00-2.43) for newly diagnosed diabetic subjects according to the WHO and ADA criteria, respectively. The WHO and ADA criteria had similar levels of reproducibility The overall K was 0.59 (0.54-0.64) for WHO criteria and 0.61 (0.56-0.66) for ADA criteria. For the category of newly diagnosed diabetes according to WHO or ADA, the percentages of agreement for the second test compared with the first test were 77% (85/110) and 74% (74/100), respectively.


CONCLUSIONS
Both sets of diagnostic criteria identify criteria-specific diabetic subjects with an increased mortality risk compared with normal subjects, and the reproducibility of both criteria is similar.
de Vegt
F
F
Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
Dekker
J M
JM
Stehouwer
C D
CD
Nijpels
G
G
Bouter
L M
LM
Heine
R J
RJ
D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000401:mortality*; D015331:Cohort Studies; D003920:Diabetes Mellitus; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012016:Reference Values; D015203:Reproducibility of Results; D012307:Risk Factors; D015996:Survival Rate; D014481:United States; D014837:Voluntary Health Agencies; D014944:World Health Organization
D001786:Blood Glucose