[The action in vitro of a permanent and an alternating magnetic field and of cytosar on the colony- and cluster-forming properties of bone marrow cells from hematologic patients].
The bone marrow of hematological patients was studied as were effects of cytozar at different dilutions on the bone marrow cells. The analysis of the secured results showed the magnetic field to be a powerful biologically active factor capable of changing clonogenic properties, proliferative and differentiative potential of hemopoietic cells precursors. A long exposure brings about a decline in the colony-forming activity of bone-marrow cells, that is to say, with prolongation of time of the exposition the magnetic field becomes an unfavourable factor for the leukotic cell culture development. Similar results were obtained with cytozar in the culture while studying the colony-forming capability of bone-marrow cells. Hence it appears that action of magnetic field under long exposition to it, combined exposure to magnetic fields, are, in some cases, comparable to effects of cytozar. It is possible that concurrent prescription of cytozar together with magnetization of blood in patients with hemoblastoses should permit enhancing the efficacy of treatment. Employment of weak magnetic fields is a satisfactory and worth-while therapeutic attempt to be made in a multimodality treatment of patients with hemoblastoses.
Bessmel'tsev
S S
SS
Balashova
V A
VA
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology* / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D003114:Colony-Forming Units Assay / Q000379:methods / Q000706:statistics & numerical data; D003561:Cytarabine / Q000494:pharmacology* / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008280:Magnetics / Q000627:therapeutic use; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine
Vozdeĭstvie in vitro postoiannogo i peremennogo magnitnogo polia i tsitozara na kolonie- i klasteroobrazuiushchie svoĭstva kletok kostnogo mozga gematologicheskikh bol'nykh.