Drug-induced linear immunoglobulin A bullous disease that clinically mimics toxic epidermal necrolysis.
Drug-induced linear immunoglobulin A bullous disease is a subepidermal blistering disorder that most commonly occurs after exposure to vancomycin. It can clinically mimic toxic epidermolytic necrolysis. We describe an 87-year-old white woman in whom linear immunoglobulin A bullous disease developed while she was taking vancomycin and phenytoin. A few days after the linear immunoglobulin A bullous disease developed, both medications were discontinued. No new bullae developed, and the eruption completely resolved within 2 weeks. The patient was treated with only topical therapy.
Mofid
M Z
MZ
Department of Dermatology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
Costarangos
C
C
Bernstein
B
B
Wong
L
L
Munster
A
A
Nousari
H C
HC
D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D010391:Pemphigoid, Bullous / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis* / Q000473:pathology; D014640:Vancomycin / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D007070:Immunoglobulin A; D014640:Vancomycin