NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors.
We have identified a new splicing variant of the gene "novel amplified in breast cancer 1," NABC1 (HGMW-approved symbol BCAS1). This variant, which we call NABC1_5B, uses a previously unidentified 135-bp exon. Also in this report, we confirm that NABC1 is overexpressed in breast tumors and show that both NABC1 and NABC1_5B are downregulated in colorectal tumors.
Correa
R G
RG
Ludwig Institute for Cancer Research, São Paulo, Brazil.
de Carvalho
A F
AF
Pinheiro
N A
NA
Simpson
A J
AJ
de Souza
S J
SJ
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation; D020224:Expressed Sequence Tags; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012007:Rectum / Q000378:metabolism
C113699:BCAS1 protein, human; D009363:Neoplasm Proteins