SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp. I. Fermentation, isolation and properties.
Two novel inhibitors of isoleucyl tRNA synthetase designated SB-203207 and SB-203208 have been detected in the culture of a new Streptomyces species. The fermentation, isolation and some properties of the inhibitors are described.
Stefanska
A L
AL
SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK.
Cassels
R
R
Ready
S J
SJ
Warr
S R
SR
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007192:Indenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007533:Isoleucine-tRNA Ligase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D051381:Rats; D013302:Streptomyces; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D007192:Indenes; C410786:SB 203207; C410787:SB 203208; D013449:Sulfonamides; D007533:Isoleucine-tRNA Ligase