title: Plasma lipid and lipoprotein responsiveness to dietary fat and cholesterol in premenopausal African American and white women.
abstract: BACKGROUND
  Premenopausal African American women have a 2-3 times greater incidence of coronary heart disease (CHD) than do white women. The plasma lipid responsiveness to dietary fat, which may be associated with CHD, has not been adequately studied in premenopausal African American or white women.
  
  
  OBJECTIVE
  The objective of our study was to compare the effect of diet on fasting plasma lipids and lipoproteins and postprandial lipemia in premenopausal African American and white women.
  
  
  METHODS
  Thirteen African American and 9 white healthy premenopausal women were fed a low-fat, high-fiber diet and a high-fat, low-fiber diet for 4 wk each in a randomized crossover design. Fasting plasma lipid and lipoprotein concentrations and the 24-h plasma triacylglycerol response to a standard fatty test meal were measured at the end of each dietary period.
  
  
  RESULTS
  Plasma total and LDL-cholesterol concentrations were higher after the high-fat, low-fiber diet in both white and African American women (P < 0.0001). The 24-h area under the plasma triacylglycerol curve after the test meal was lower after the low-fat diet than after the high-fat diet (P < 0.04).
  
  
  CONCLUSIONS
  African American and white women had lower fasting plasma total and LDL-cholesterol concentrations and less postprandial lipemia after the low-fat than the high-fat diet. Diets low in total and saturated fat and cholesterol and high in fiber may reduce the risk of CHD by lowering fasting plasma total and LDL-cholesterol concentrations and by reducing the lipemic response to fatty meals.
authors.affiliation: Oregon Health Sciences University, Division of Endocrinology, Diabetes, and Clinical Nutrition, Portland, Oregon 97201-3098, USA.
authors.forename: G T
authors.initials: GT
authors.lastname: Gerhard
authors.forename: S L
authors.initials: SL
authors.lastname: Connor
authors.forename: R C
authors.initials: RC
authors.lastname: Wander
authors.forename: W E
authors.initials: WE
authors.lastname: Connor
mesh_terms: D000293:Adolescent; D000328:Adult; D044383:Black People; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000235:genetics* / Q000517:prevention & control; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged; D019518:Postprandial Period; D017697:Premenopause; D014280:Triglycerides / Q000097:blood; D044465:White People; D016387:Women's Health; D001741:Black or African American
chemical_list: D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D004043:Dietary Fiber; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides