Single-molecule studies of DNA mechanics.
During the past decade, physical techniques such as optical tweezers and atomic force microscopy were used to study the mechanical properties of DNA at the single-molecule level. Knowledge of DNA's stretching and twisting properties now permits these single-molecule techniques to be used in the study of biological processes such as DNA replication and transcription.
Bustamante
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Department of Molecular and Cell Biology, Department of Physics, University of California, Berkeley, CA 94720, USA. carlos@alice. berkeley.edu.
Smith
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Liphardt
J
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Smith
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D000818:Animals; D004247:DNA / Q000737:chemistry*; D004548:Elasticity; D006801:Humans; D009690:Nucleic Acid Conformation
D004247:DNA