The role of the oocyte in folliculogenesis.
Novel regulatory proteins have been identified within oocytes that are crucially involved in folliculogenesis. One of the most exciting oocyte signaling molecules is a novel member of the transforming growth factor beta (TGF-beta) superfamily, growth differentiation factor 9 (GDF-9). Loss-of-function studies have established that GDF-9 is obligatory for proper folliculogenesis and fertility in female mice. The current challenges are to understand how oocyte morphogens regulate folliculogenesis and how their actions and interactions are integrated into the overall processes of physiology and pathophysiology. Who would have thought that oocyte morphogens would be so crucial for reproduction?
Erickson
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Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093-0674, USA. gerickson@ucsd.edu
Shimasaki
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D000818:Animals; D055430:Bone Morphogenetic Protein 15; D005260:Female; D055429:Growth Differentiation Factor 9; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000502:physiology; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology*
C525902:Bmp15 protein, mouse; D055430:Bone Morphogenetic Protein 15; C525898:Gdf9 protein, mouse; D055429:Growth Differentiation Factor 9; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins