[The ultrastructural changes in the cellular lining of lymph node sinuses in organochlorine pesticide poisoning].
In conditions of exotoxicosis arising after the effect of 2,4-dichlorphenoxyacetic acid cytoplasmic cells of littoral cells of marginal and medullary sinuses undergo alike changes and their cell organelles (rough endoplasmic reticulum, Golgi complex, micropinocytotic vesicles and mitochondria) mass is reduced. These changes are more pronounced in littoral cells of marginal sinus when the dos under the effect of 4 permissible doses of the poison. Intensity of intracellular structures reaction to the toxicant action depends on the cell localization on the lymph passage insid within the lymph node (marginal or medullar sinuses). Dystrophic changes in sinus lining cells so as the speed and character of regenerative processes depend on the dose and time of action of the agent.
Borodin
Iu I
IuI
Laboratory of Ultrastructural Changes,Siberian Section, Russian Academy of Sciences, Novosibirsk.
Nurmukhambetova
B N
BN
D015084:2,4-Dichlorophenoxyacetic Acid / Q000506:poisoning*; D000818:Animals; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000506:poisoning*; D008198:Lymph Nodes / Q000648:ultrastructure*; D008297:Male; D008643:Mesentery; D011041:Poisoning / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid
Ul'trastrukturnye izmeneniia kletochnoĭ vystilki v sinusakh kimfaticheskikh uzlov pri otravlenii khlororganicheskim pestitsidom.