Role of cysteine endopeptidases in cancerogenesis.
Role of cysteine endopeptidases in cancerogenesis steps: neoplastic transformation, invasion and metastasis is reviewed and discussed. Positive correlation between tumor invasiveness, as well as its metastatic potential and secretion of cysteine endopeptidase (particularly cathepsins B and L) has been documented well in literature. Based on our recent results we postulate that serum endopeptidase-like activity could be used as a marker of cancer aggressiveness in diagnostic procedures in oncology. We also propose that the cysteine endopeptidase inhibitor levels (total, active and latent) could be useful factors for recognising the activation of the organism self-defence mechanisms against cancer. In addition, our idea of use of urinary cysteine peptidase inhibitors (UCPI) as potential anticancer agents is presented and discussed.
Siewinski
M
M
Department of Biochemistry, Wrocław University of Medicine, Poland.
Gutowicz
J
J
Zarzycki
A
A
Mikulewicz
W
W
D002471:Cell Transformation, Neoplastic; D003546:Cysteine Endopeptidases / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology*
D003546:Cysteine Endopeptidases