Identification of the origin of a vesical mass occurring after cadaveric renal transplantation using short tandem repeat markers.
We report a case of polypoid cystitis in a 54-year-old female occurring 4 years after cadaveric kidney transplantation. Endoscopic exploration revealed a polypoid tumor near the stoma opened for the transplanted ureter. The diagnosis of polypoid cystitis was confirmed histopathologically. Genotyping of cells from the tumor with polymorphic short tandem repeat (STR) and amelogenin loci revealed that the tumor contained alleles from both the donor and recipient. Molecular genetic analysis provided strong evidence that the tumor cells arose from the donor tissue.
Yamamoto
N
N
Department of Urology, Gifu University School of Medicine, Japan.
Nagai
A
A
Kuriyama
M
M
Ishihara
S
S
Ohya
I
I
Deguchi
T
T
D002102:Cadaver; D003556:Cystitis / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D011127:Polyps / Q000235:genetics*; D011183:Postoperative Complications / Q000209:etiology* / Q000473:pathology; D020080:Tandem Repeat Sequences; D001749:Urinary Bladder Neoplasms / Q000235:genetics*