Calcium, a signaling molecule in the endoplasmic reticulum?
For many years now, it has been known that Ca2+ is an important signaling molecule in the cytosol of the cell, but emerging evidence suggests that Ca2+ might also play a signaling role in the endoplasmic reticulum. For example, agonist-induced fluctuations in free Ca2+ concentration in the endoplasmic reticulum can affect many functions of the endoplasmic reticulum, including protein synthesis and modification, and interchaperone interactions.
Corbett
E F
EF
MRC Group in Molecular Biology of Membranes and the Department of Biochemistry, University of Alberta, Edmonton, AL, Canada T6G 2H7.
Michalak
M
M
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D037282:Calreticulin; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*; D006360:Heat-Shock Proteins / Q000378:metabolism; D007535:Isomerases / Q000378:metabolism; D018832:Molecular Chaperones / Q000737:chemistry / Q000378:metabolism; D019704:Protein Disulfide-Isomerases / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D012261:Ribonucleoproteins; D007535:Isomerases; D019704:Protein Disulfide-Isomerases; D002118:Calcium