The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes.
Varying concentrations of octreotide acetate (Sandostatin) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37 degrees C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The results indicate that octreotide acetate remains stable in the presence of diamorphine hydrochloride at 37 degrees C for 24 h. In addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions.
Fielding
H
H
Western General Hospital, Edinburgh.
Kyaterekera
N
N
Skellern
G G
GG
Tettey
J N
JN
McDade
J R
JR
Msuya
Z
Z
Watson
D G
DG
Urie
J
J
D000701:Analgesics, Opioid / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D005765:Gastrointestinal Agents / Q000737:chemistry*; D003932:Heroin / Q000737:chemistry*; D006801:Humans; D015282:Octreotide / Q000737:chemistry*; D010166:Palliative Care; D013594:Syringes
D000701:Analgesics, Opioid; D004338:Drug Combinations; D005765:Gastrointestinal Agents; D003932:Heroin; D015282:Octreotide