[Localized bullous eruption after intravenous injection of aciclovir: toxic or immunoallergic mechanism?].
OBJECTIVE
To report a case of bullous eruption at and far from the site of aciclovir injection.


METHODS
A 50-year-old man was treated with intravenous aciclovir for Herpes simplex meningoencephalitis. Ten days after treatment onset, blisters appeared on his right forearm, at and far from the site of aciclovir injection.


CONCLUSIONS
This adverse effect has not been frequently reported. To date, bullous eruptions were considered to result from extravasation of the aciclovir solution. In this case, an immunoallergic pattern was discussed with the presence of a histological leukocytoclastic vasculitis.
Armingaud
P
P
Service de Dermatologie, Hôpital Porte-Madeleine, CHR d'Orléans, 45067 Orléans Cedex 01.
Arsac
P
P
Kerdraon
R
R
Esteve
E
E
D000212:Acyclovir / Q000009:adverse effects* / Q000276:immunology; D000998:Antiviral Agents / Q000009:adverse effects* / Q000276:immunology; D001768:Blister / Q000139:chemically induced* / Q000276:immunology; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy; D005542:Forearm; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000209:etiology
D000998:Antiviral Agents; D000212:Acyclovir
Eruption bulleuse localisée après injection intraveineuse d'aciclovir: mécanisme toxique ou immunoallergique?