Discovery of a potent, non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase.
3-Cyclopropanecarbonyloxy-2-cyclohexen-1-one has been found to be a new, potent, low molecular weight non-triketone type inhibitor of 4-hydroxyphenylpyruvate dioxygenase with IC50 value of 30 nM. Preliminary studies suggest that the two carbonyl groups present in the compound are crucial for the inhibition activity.
Lin
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SW
Department of Chemistry, Tunghai Christian University, Taichung, Taiwan, ROC.
Lin
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YL
Lin
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TC
Yang
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DY
D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007659:Ketones / Q000737:chemistry*
D004791:Enzyme Inhibitors; D007659:Ketones; D015111:4-Hydroxyphenylpyruvate Dioxygenase