title: [The effect of medikhronal on the psychophysiological and metabolic processes in alcoholism].
abstract: Pathopsychological examination, biochemical analysis of blood and urine as well as electroencephalogram (REG) were made in patients of the second (II) stage of alcoholism. The state of higher nervous activity (HNA) before and after treatment with antialcoholic drug medichronal was also analyzed. It has been shown that the course of treatment with medichronal applied to patients with alcoholism results in the removal of the inclination to alcohol, to improvement of functional state of the central nervous system, as well as ethanol (E), acetaldehyde (AcA) and catecholamines (CA) exchange, the disturbances in their metabolism (and first of all AcA) apparently being the basis of pathogenetic mechanisms of alcoholism.
authors.affiliation: Ukrainian Scientific-Research Institute of Social and Forensic Psychiatry, Ministry of Public Health of Ukraine, Kiev.
authors.forename: N K
authors.initials: NK
authors.lastname: Kharchenko
authors.forename: P Iu
authors.initials: PIu
authors.lastname: Duplenko
authors.forename: T V
authors.initials: TV
authors.lastname: Kovtun
authors.forename: N A
authors.initials: NA
authors.lastname: Stohniĭ
authors.forename: V M
authors.initials: VM
authors.lastname: Synyts'kyĭ
mesh_terms: D000328:Adult; D000427:Alcohol Deterrents / Q000494:pharmacology / Q000627:therapeutic use*; D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004338:Drug Combinations; D004569:Electroencephalography / Q000187:drug effects; D005561:Formates / Q000494:pharmacology / Q000627:therapeutic use*; D005947:Glucose / Q000494:pharmacology / Q000627:therapeutic use*; D005998:Glycine / Q000494:pharmacology / Q000627:therapeutic use*; D006613:Higher Nervous Activity / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D011603:Psychophysiology
chemical_list: D000427:Alcohol Deterrents; D004338:Drug Combinations; D005561:Formates; C088648:medikhronal; D005947:Glucose; D005998:Glycine
vernacular_title: Vplyv medykhronalu na psykhofiziolohichni ta metabolichni protsesy pry alkoholizmi.