Eicosanoids and the esophagus.
Eicosanoids are products of arachidonic acid metabolism. Among the products produced are the prostaglandins and leukotrienes, products which are known to play important roles in health and disease of many gastrointestinal tissues. Here, we review current knowledge about eicosanoids in the esophagus, including production in healthy and diseased tissues and potential physiologic and pathophysiologic effects in two important esophageal mucosal disorders, reflux esophagitis and esophageal cancer.
Long
J D
JD
Department of Medicine, Division of Digestive Diseases, University of Cincinnati Medical Center, OH 45267, USA.
Orlando
R C
RC
D000818:Animals; D015777:Eicosanoids / Q000378:metabolism / Q000502:physiology*; D004935:Esophageal Diseases / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology; D004938:Esophageal Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology; D004947:Esophagus / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D015777:Eicosanoids; D011451:Prostaglandin-Endoperoxide Synthases