title: Childhood cancer in the offspring of male sawmill workers occupationally exposed to chlorophenate fungicides.
abstract: The objective of this study was to determine whether paternal occupational exposure to chlorophenol fungicides and their dioxin contaminants is associated with childhood cancer in the offspring of sawmill workers. We used data from 23,829 British Columbian sawmill workers employed for at least 1 continuous year between 1950 and 1985 in 11 sawmills that used chlorophenates. Probabilistic linkage of the sawmill worker cohort to the provincial marriage and birth files produced an offspring cohort of 19,674 children born at least 1 year after the initiation of employment in the period 1952-1988. We then linked the offspring cohort to the British Columbia Cancer Registry. We included all malignancies in cases younger than 20 years of age that appeared on the cancer registry between 1969 and 1993. We calculated standardized incidence ratios (SIRs) using the British Columbia population as a reference. A nested case-control analysis assessed the effects of paternal cumulative exposure and windows of exposure on the risk of developing cancer in the offspring. We identified 40 cases of cancer during 259,919 person-years of follow-up. The all-cancer SIR was 1.0 [95% confidence interval (CI), 0.7-1.4]; the SIR for leukemia was 1.0 (CI, 0.5-1.8); and the SIR for brain cancer was 1.3 (CI, 0.6-2.5). The nested case-control analysis showed slightly increased risks in the highest categories of chlorophenol exposure, although none was statistically significant. Our analyses provide little evidence to support a relationship between the risk of childhood cancer and paternal occupational exposure to chlorophenate fungicides in British Columbian sawmills.
authors.affiliation: Department of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: H
authors.initials: H
authors.lastname: Heacock
authors.forename: C
authors.initials: C
authors.lastname: Hertzman
authors.forename: P A
authors.initials: PA
authors.lastname: Demers
authors.forename: R
authors.initials: R
authors.lastname: Gallagher
authors.forename: R S
authors.initials: RS
authors.lastname: Hogg
authors.forename: K
authors.initials: K
authors.lastname: Teschke
authors.forename: R
authors.initials: R
authors.lastname: Hershler
authors.forename: C D
authors.initials: CD
authors.lastname: Bajdik
authors.forename: H
authors.initials: H
authors.lastname: Dimich-Ward
authors.forename: S A
authors.initials: SA
authors.lastname: Marion
authors.forename: A
authors.initials: A
authors.lastname: Ostry
authors.forename: S
authors.initials: S
authors.lastname: Kelly
mesh_terms: D000293:Adolescent; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D002733:Chlorophenols / Q000009:adverse effects*; D015331:Cohort Studies; D004147:Dioxins / Q000009:adverse effects*; D005260:Female; D005659:Fungicides, Industrial / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D016273:Occupational Exposure; D018812:Paternal Exposure; D018570:Risk Assessment
chemical_list: D002733:Chlorophenols; D004147:Dioxins; D005659:Fungicides, Industrial