Anti-adhesive activity of sulphated exopolysaccharides of microalgae on attachment of red sore disease-associated bacteria and helicobacter pylori to tissue culture cells.
Because of the affinity of certain bacterial species for sulphated glycoconjugates exposed on the epithelial cells of susceptible hosts, we hypothesized that sulphated exopolysaccharides of microalgae can be used in anti-adhesive therapies against bacterial infections, both in cold- and warm-blooded animals. In this study we found that adhesion of the human pathogen Helicobacter pylori to the HeLa S3 cell line, and adhesion of the fish pathogens Vibrio campbellii, V. ordalii, Streptococcus saprophyticus, and Aeromonas veronii to spotted sand bass primary tissue culture cells, can be effectively blocked with the various sulphated exopolysaccharides used.
Guzman-Murillo
M A
MA
Center for Biological Research, Department of Marine Pathology, La Paz, Mexico.
Ascencio
F
F
D000333:Aeromonas / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D001492:Bass; D002478:Cells, Cultured; D056890:Eukaryota / Q000737:chemistry; D005393:Fish Diseases / Q000517:prevention & control; D006367:HeLa Cells; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D017192:Skin Diseases, Bacterial / Q000517:prevention & control; D013291:Streptococcus / Q000187:drug effects / Q000502:physiology; D014733:Vibrio / Q000187:drug effects / Q000502:physiology; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D011134:Polysaccharides