[Level of placental alpha1-microglobulin in maternal serum as a marker of intrauterine fetal pathology].
Serum levels of placental alpha 1-microglobulin (PAMG) were measured during the third trimester in 21 women with normal pregnancy, 24 with extragenital diseases, and 57 with gestosis. Abnormally high levels of PAMG were detected in 23 women, 4 of these with clinically uneventful pregnancy. All pregnancies in the group with high concentrations of PAMG had unfavorable outcomes with the following diagnoses at birth: intrauterine hypoxia (14 cases), low-weight babies (5 cases), small-for-date fetuses (2 cases), preterm delivery (1 case), and asphyxia (1 case). Therefore, a high level of PAMG is an indicator of intrauterine disease even in cases when there are no clinical symptoms of pregnancy abnormalities.
Rybka
I D
ID
Boltovskaia
M N
MN
Marshitskaia
M I
MI
Starosvetskaia
N A
NA
Nazimova
V
V
D015415:Biomarkers; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008562:Membrane Glycoproteins; D010920:Placenta / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014360:Trypsin Inhibitor, Kunitz Soybean
D015415:Biomarkers; D006023:Glycoproteins; D008562:Membrane Glycoproteins; C109148:SPINT2 protein, human; D014360:Trypsin Inhibitor, Kunitz Soybean
Uroven' platsentarnogo alpha1-mikroglobulina v materinskoĭ syvorotke kak pokazatel' vnutriutrobnoĭ patologii ploda.