Pathological findings of tissue reactivity of gelatin resorcin formalin glue: an autopsy case report of the repair of ventricular septal perforation.
A seventy-three-year-old man was treated for ventricular septal perforation with Gelatin Resorcin Formalin (GRF) glue. The patient died of multiple organ failure 36 days after the surgery. In autopsy, macroscopically, the inferior wall was reconstructed successfully by the GRF glue. Furthermore, microscopic study revealed the excellent growth of collagen and elastic fiber where the GRF was glued. No infiltration of inflammatory cells was evident. There have been no reports that the safety and efficacy of GRF glue was pathologically proven in an autopsy case.
Hata
M
M
Department of Cardiovascular Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-0081, Japan.
Shiono
M
M
Orime
Y
Y
Yamamoto
T
T
Yagi
S Y
SY
Okumura
H
H
Kimura
S I
SI
Kashiwazaki
S
S
Choh
S
S
Niino
T
T
Negishi
N
N
Sezai
Y
Y
Yamada
T
T
Murakami
H
H
D000368:Aged; D020099:Coated Materials, Biocompatible; D003094:Collagen; D004338:Drug Combinations; D004547:Elastic Tissue / Q000187:drug effects / Q000473:pathology; D017809:Fatal Outcome; D005557:Formaldehyde / Q000627:therapeutic use*; D005780:Gelatin / Q000627:therapeutic use*; D006346:Heart Septum / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology; D011138:Polytetrafluoroethylene; D019919:Prosthesis Implantation / Q000379:methods; D012118:Resorcinols / Q000627:therapeutic use*; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000627:therapeutic use*; D018658:Ventricular Septal Rupture / Q000209:etiology / Q000473:pathology* / Q000601:surgery*
D020099:Coated Materials, Biocompatible; D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin; D011138:Polytetrafluoroethylene; D003094:Collagen