title: Development and function of B-1 cells.
abstract: Results from immunoglobulin-transgenic mice and BCR-mutant mice have been widely interpreted in recent years as supporting a simple 'activation' model for the origin of CD5+/B-1 B cells. However cell transfer experiments over 10 years ago and recent work investigating pre-BCR signaling suggest striking differences between B cell development in fetal liver and adult bone marrow, lending support for a 'lineage' model that we favor. Recent progress has been made relating to the development and function of the CD5+/B-1 B cell subpopulation in mice; the data can be viewed in the context of the generation of this subpopulation by a distinctive fetal B cell developmental process.
authors.affiliation: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: K
authors.initials: K
authors.lastname: Hayakawa
authors.forename: R R
authors.initials: RR
authors.lastname: Hardy
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D001854:Bone Marrow Cells / Q000276:immunology; D018956:CD5 Antigens; D019070:Cell Lineage; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007107:Immune System / Q000196:embryology / Q000254:growth & development; D008099:Liver / Q000166:cytology / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D015398:Signal Transduction
chemical_list: D018956:CD5 Antigens