A severe clinical phenotype results from the co-inheritance of type 2 susceptibility genes and a hepatocyte nuclear factor-1alpha mutation.
Tack
C J
CJ
Ellard
S
S
Hattersley
A T
AT
D000328:Adult; D019943:Amino Acid Substitution; D002096:C-Peptide / Q000097:blood; D004268:DNA-Binding Proteins / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D020022:Genetic Predisposition to Disease; D006442:Glycated Hemoglobin / Q000032:analysis; D051537:Hepatocyte Nuclear Factor 1; D051538:Hepatocyte Nuclear Factor 1-alpha; D051539:Hepatocyte Nuclear Factor 1-beta; D006801:Humans; D008297:Male; D009687:Nuclear Proteins; D010375:Pedigree; D010641:Phenotype; D017354:Point Mutation; D014157:Transcription Factors / Q000235:genetics*
D002096:C-Peptide; D004268:DNA-Binding Proteins; D006442:Glycated Hemoglobin; D051537:Hepatocyte Nuclear Factor 1; D051538:Hepatocyte Nuclear Factor 1-alpha; D051539:Hepatocyte Nuclear Factor 1-beta; D009687:Nuclear Proteins; D014157:Transcription Factors; C496487:HNF1A protein, human; C496495:HNF1B protein, human