title: Application of a genetic algorithm to optimizing radiation therapy treatment plans for pancreatic carcinoma.
abstract: The performance of an automated treatment planning algorithm was tested using cases of patients with pancreatic carcinoma; the system implements optimization tools that suggest high-quality plans for consideration by the planner and physician, making best use of the capabilities of a conventional linear accelerator: isocentric setup, shaped fields, and wedges. Ten consecutive patients presenting with pancreatic cancer were first planned using a conventional 3-field protocol to provide a basis for comparison. Each was then planned using an automated optimization technique using a genetic algorithm and a dose-based score function subject to volume-dose constraints. Two sets of optimized plans were created, 1 using only axial beams and the other permitting non-axial beams. The improvement afforded by the optimization was assessed by comparing the score function results and by computing the combined normal tissue complication probability (NTCP) for a constant isocenter dose. In all 10 cases, optimization improved the dose-based score function. In 9 cases, the non-axial plan scored higher than the axial plan. Optimization driven by the dose-based score function improved or equaled the predicted NTCP in 8 axial and 9 nonaxial plans. This study demonstrates progress toward the goal of developing an automated planning tool that can robustly suggest high-quality plans.
authors.affiliation: Department of Radiation Oncology, Karmanos Cancer Institute and Wayne State University, Detroit, MI, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Ezzell
authors.forename: L
authors.initials: L
authors.lastname: Gaspar
mesh_terms: D000465:Algorithms; D006801:Humans; D010190:Pancreatic Neoplasms / Q000532:radiotherapy*; D011880:Radiotherapy Planning, Computer-Assisted