title: Cardiac troponin I in fulminant adenovirus myocarditis treated with a 24-hour infusion of high-dose intravenous immunoglobulin.
abstract: We report a successful outcome on an acute adenovirus myocarditis treated with a 24-hour high-dose intravenous immunoglobulin (24-HDIVIG) in a 4.5-year-old girl. A postviral etiology of acute myocarditis was assessed on the basis of the polymerase chain reaction technique. Among other early markers of cardiac injury, cardiac isoform of troponin-I (cTnI) was significantly correlated to the left ventricular ejection fraction (r = -0.86, p < 0.0001). Follow-up of cTnI, which might also be correlated to the short-term outcome, allows fast, easy, and noninvasive estimation of response to the aggressive treatment with 24-HDIVIG in acute adenovirus myocarditis in children.
authors.affiliation: Pediatric Intensive Care Unit, Aghia Sophia Children's Hospital, Levadias & Thivon Street, Athens, Greece.
authors.forename: G
authors.initials: G
authors.lastname: Briassoulis
authors.forename: G
authors.initials: G
authors.lastname: Papadopoulos
authors.forename: N
authors.initials: N
authors.lastname: Zavras
authors.forename: V
authors.initials: V
authors.lastname: Pailopoulos
authors.forename: T
authors.initials: T
authors.lastname: Hatzis
authors.forename: V
authors.initials: V
authors.lastname: Thanopoulos
mesh_terms: D000257:Adenoviridae Infections / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D009205:Myocarditis / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology / Q000821:virology*; D016133:Polymerase Chain Reaction; D020033:Protein Isoforms; D019210:Troponin I / Q000032:analysis*; D016277:Ventricular Function, Left
chemical_list: D016756:Immunoglobulins, Intravenous; D020033:Protein Isoforms; D019210:Troponin I