Towards a molecular understanding of polycythemia rubra vera.
Polycythemia rubra vera (PV) is one of four diseases collectively called the myeloproliferative disorders (MPDs). Each disorder leads to an increased production of one or several hematopoietic cell lineages. MPDs arise from acquired mutations in a pluripotent hematopoietic stem cell. However, the molecular mechanisms leading to the development of these diseases are poorly understood. This review will summarize and evaluate recent advances in our understanding of one particular MPD, PV.
Pahl
H L
HL
Division of Experimental Anaesthesiology, University Hospital Freiburg, Center for Tumor Biology, Germany. pahl@uni-freiburg.de
D004921:Erythropoietin / Q000378:metabolism*; D058851:GPI-Linked Proteins; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007519:Isoantigens; D008562:Membrane Glycoproteins; D009196:Myeloproliferative Disorders / Q000209:etiology / Q000473:pathology; D009363:Neoplasm Proteins; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011087:Polycythemia Vera / Q000209:etiology* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D018121:Receptors, Cytokine; D017467:Receptors, Erythropoietin / Q000378:metabolism; D053628:Receptors, Thrombopoietin; D015398:Signal Transduction; D013234:Stem Cells / Q000473:pathology / Q000502:physiology; D051020:bcl-X Protein
C494811:BCL2L1 protein, human; C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D006133:Growth Substances; D007519:Isoantigens; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011956:Receptors, Cell Surface; D018121:Receptors, Cytokine; D017467:Receptors, Erythropoietin; D053628:Receptors, Thrombopoietin; D051020:bcl-X Protein; D004921:Erythropoietin; C082218:MPL protein, human; D010749:Phosphoprotein Phosphatases