[Anaerobic formation of succinate and facilitation of its oxidation -- possible mechanisms of cell adaptation to oxygen deficiency].
An important role of anaerobic formation of succinate in anoxic and hypoxic states and the activation of succinate oxidation under hypoxia were shown. It was concluded that, for maintaining the energetics of animal cells under conditions of oxygen deficiency, it is advisable to use substrates capable of participating in the anaerobic formation of succinate, whereas under hypoxia it is reasonable to use succinate itself.
Maevskiĭ
E I
EI
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
Grishina
E V
EV
Rozenfel'd
A S
AS
Ziakun
A M
AM
Vereshchagina
V M
VM
Kondrashova
M N
MN
D000220:Adaptation, Biological; D000818:Animals; D015687:Cell Hypoxia; D010084:Oxidation-Reduction; D010100:Oxygen; D019802:Succinic Acid / Q000737:chemistry*
D019802:Succinic Acid; D010100:Oxygen
Anaérobnoe obrazovanie suktsinata i oblegchenie ego okisleniia-- vozmozhnye mekhanizmy adaptatsii kletki k kislorodnomu golodaniiu.