title: Stereotactic radiosurgery in the treatment of metastatic disease to the brain.
abstract: We review 190 consecutive patients with 434 metastatic tumors treated by gamma knife stereotactic radiosurgery, from August 1994 to February 1999. Median actuarial survival for all patients was 34 weeks. Factors correlated with significantly improved survival included controlled systemic disease and nonmelanoma histology. We found that no significant survival benefit could be discerned from adjuvant whole brain radiotherapy in this patient group. Survival was not statistically different for patients initially presenting with 1-4 metastases at initial treatment.
authors.affiliation: Departments of Neurological Surgery and Radiation, Oncology, Biology and Physics, University of Southern California School of Medicine, Los Angeles 90033, USA. josephcc@hsc.usc.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: O'Day
authors.forename: D
authors.initials: D
authors.lastname: Morton
authors.forename: R
authors.initials: R
authors.lastname: Essner
authors.forename: A
authors.initials: A
authors.lastname: Cohen-Gadol
authors.forename: D
authors.initials: D
authors.lastname: MacPherson
authors.forename: S L
authors.initials: SL
authors.lastname: Giannotta
authors.forename: Z
authors.initials: Z
authors.lastname: Petrovich
authors.forename: C
authors.initials: C
authors.lastname: Yu
authors.forename: M L
authors.initials: ML
authors.lastname: Apuzzo
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D016634:Radiosurgery; D013238:Stereotaxic Techniques; D016019:Survival Analysis