Separation of drugs by packed-column supercritical fluid chromatography.
Packed-column supercritical fluid chromatography (pSFC) has been expected to analyze various kinds of compounds. Many researchers have expected a new chromatographic technique that overcomes the limitations of other techniques, HPLC and GC. In pharmaceutical development, chromatography plays an important role in the evaluation of safety and efficacy of a new compound. This article provides an overview of the separation of drugs by pSFC. The effects of the chromatographic parameters were studied for the separation of steroids. In chiral separation, the successful results were shown and compared with HPLC.
Yaku
K
K
Analytical Chemistry Department, Product & Technology Development Laboratory, Tanabe Seiyaku Co., Ltd., 16-89, Kashima 3-chome, Yodogawa-ku, 532-8505, Osaka, Japan. k-yaku@tanabe.co.jp
Morishita
F
F
D000433:1-Propanol / Q000737:chemistry; D019840:2-Propanol / Q000737:chemistry; D002845:Chromatography / Q000295:instrumentation* / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D000431:Ethanol / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D019999:Pharmaceutical Solutions / Q000302:isolation & purification*; D011312:Pressure; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification; D013696:Temperature; D013816:Thermodynamics; D013997:Time Factors
D019999:Pharmaceutical Solutions; D013256:Steroids; D000431:Ethanol; D000433:1-Propanol; D019840:2-Propanol; D000432:Methanol