Effects of sub-chronic combined treatment with pergolide and caffeine on contralateral rotational behavior in unilateral 6-hydroxydopamine-denervated rats.
We studied the synergistic effects of pergolide and bromocriptine with caffeine on turning behavior in 6-OHDA denervated rats. Both pergolide and bromocriptine were synergistic with caffeine, and prevented tolerance to caffeine-induced turning. When caffeine was removed, tolerance to bromocriptine effects was observed for 1 day only, while no tolerance was observed to pergolide. These results suggest that caffeine could be useful in the treatment of Parkinson's disease, preferentially as an adjuvant of mixed dopaminergic agonists like pergolide.
Prat
G
G
Laboratori de Neuropsicofarmacologia, Unitat de Toxicomanies, Institut de Recerca de L'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Robledo
P
P
Rubio
A
A
Barbanoj
M
M
Jané
F
F
Casas
M
M
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology; D002110:Caffeine / Q000494:pharmacology*; D003714:Denervation; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004361:Drug Tolerance / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010479:Pergolide / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012399:Rotation
D004338:Drug Combinations; D010479:Pergolide; D001971:Bromocriptine; D002110:Caffeine; D016627:Oxidopamine