[The MDR gene and cellular sensitivity to various effects].
mdr-Transfected K-562 cells revealed a relatively high resistance to cytotoxic monokines and ionizing radiation as compared to parental cells. Taken together with what is known about the resistance of mdr-expressing cells to multiple cytotoxic drugs, our results point to malignant cells having universal mechanisms of chemo-, bio- and radioresistance.
Zubova
S G
SG
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Danilov
A O
AO
Myshkov
A I
AI
Bykova
T V
TV
Zaritskiĭ
A Iu
AIu
Okulov
V B
VB
D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D019450:Genes, MDR; D006801:Humans; D020014:K562 Cells / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D008264:Macrophages / Q000187:drug effects / Q000528:radiation effects; D015846:Monokines / Q000378:metabolism*; D011839:Radiation, Ionizing; D011878:Radiotherapy / Q000379:methods; D014162:Transfection
D015846:Monokines
Gen mdr i chuvstvitel'nost' kletok k razlichnym vozdeĭstviiam.