title: (3)he-MRI-based measurements of intrapulmonary p(O2) and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations.
abstract: We applied a recently developed method of following the time course of the intrapulmonary oxygen partial pressure p(O2)(t) during apnea by (3)He MRI to healthy volunteers. Using two imaging series with different interscan times during two breathholds (double acquisition technique), relaxation of (3)He due to paramagnetic oxygen and depolarization by RF pulses were discriminated. In all four subjects, the temporal evolution of p(O2) was found to be linear, and was described by an initial partial pressure p(0) and a decrease rate R. Also, regional differences of both p(0) and R were observed. A correlation between p(0) and R was apparent. Finally, we discuss limitations of the double acquisition approach.
authors.affiliation: Department of Physics, University of Mainz, Staudingerweg 7, D 55099 Mainz, Germany. deninger@mail.uni-mainz.de
authors.forename: A J
authors.initials: AJ
authors.lastname: Deninger
authors.forename: B
authors.initials: B
authors.lastname: Eberle
authors.forename: M
authors.initials: M
authors.lastname: Ebert
authors.forename: T
authors.initials: T
authors.lastname: Grossmann
authors.forename: G
authors.initials: G
authors.lastname: Hanisch
authors.forename: W
authors.initials: W
authors.lastname: Heil
authors.forename: H U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: K
authors.initials: K
authors.lastname: Markstaller
authors.forename: E
authors.initials: E
authors.lastname: Otten
authors.forename: W
authors.initials: W
authors.lastname: Schreiber
authors.forename: R
authors.initials: R
authors.lastname: Surkau
authors.forename: N
authors.initials: N
authors.lastname: Weiler
mesh_terms: D000328:Adult; D001049:Apnea / Q000503:physiopathology*; D005260:Female; D006371:Helium; D006801:Humans; D007554:Isotopes; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D012016:Reference Values; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods*; D015656:Respiratory Mechanics
chemical_list: D007554:Isotopes; D006371:Helium; D010100:Oxygen