title: [Prognostic factors in the treatment of advanced cervical cancer. A retrospective study].
abstract: BACKGROUND
  The value of prognostic factors in patients with advanced cervix carcinoma treated by radiotherapy was assessed in a retrospective study.
  
  
  METHODS
  From January 1977 through December 1990, 261 patients (average age 60 years) were treated at the Radiotherapy Department of the University of Turin. Distribution by stage was: 142 T2b (54%), 8 T3a (3%), 98 T3b (38%) and 13 T4 (5%). 83% of the patients underwent radiotherapy alone; the total dose was 45-88 Gy in 91 patients (42%) with poor clinical conditions, 60-75 Gy in 121 (56%) and 75-80 Gy in 5 cases. 17% of the patients was treated by surgery combined with radiotherapy. The median follow-up was 50 months (minimum 2, maximum 177 months).
  
  
  RESULTS
  The 5-year NED survival and local control were 42% (52% for T2b, 33% for T3 and 15% for T4). The severe (G3-G4) complication rate was very low (1.9%).
  
  
  CONCLUSIONS
  In our series, the prognostic factors which significantly influenced survival in the uni-variate analysis were: advanced T stage, contemporary infiltration of parametrium and vagina, nodal status, non squamous neoplasm, younger age and the absence of brachytherapy in the radiotherapy alone protocol.
authors.affiliation: Dipartimento di Discipline Medico-Chirurgiche, Università degli Studi, Torino.
authors.forename: M
authors.initials: M
authors.lastname: Sacco
authors.forename: M
authors.initials: M
authors.lastname: Tessa
authors.forename: M
authors.initials: M
authors.lastname: Rampino
authors.forename: R
authors.initials: R
authors.lastname: Ragona
authors.forename: C
authors.initials: C
authors.lastname: Airaldi
authors.forename: D
authors.initials: D
authors.lastname: Nassisi
authors.forename: N
authors.initials: N
authors.lastname: Rondi
authors.forename: M
authors.initials: M
authors.lastname: Gatti
authors.forename: G
authors.initials: G
authors.lastname: Garnero
authors.forename: P
authors.initials: P
authors.lastname: Rotta
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
vernacular_title: Fattori prognostici nel trattamento del cervicocarcinoma in stadio localmente avanzato. Studio retrospettivo.