High-field quantitative transverse relaxation time, magnetization transfer and apparent water diffusion in experimental rat brain tumour.
The potential of quantitative parameter images of transverse relaxation time T(2), apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) to characterize experimental brain tumours was studied. Necrosis or haemorrhage can be detected using either MTR, ADC or T(2) (necrosis-MTR reduced by 35%, ADC and T(2) increased respectively by 170% and 100% compared with normal brain tissue; haemorrhage-MTR increased by 60%, ADC and T(2) decreased by 40% and 20%, respectively). Normal brain tissue can only be distinguished from tumour on T(2) and MTR parameter images. However, for small tumours (10 microl), the best contrast is observed with MTR, ca. 30%, whereas for T(2) the contrast is ca. 10%.
Lemaire
L
L
UPRES-EA 2169 Vectorisation Particulaire, Universite d'Angers, Angers, France. laurent.lemaire@univ-angers.fr
Franconi
F
F
Saint-Andre
J P
JP
Roullin
V G
VG
Jallet
P
P
Le Jeune
J J
JJ
D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D003627:Data Interpretation, Statistical; D004058:Diffusion; D004195:Disease Models, Animal; D005260:Female; D005910:Glioma / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014867:Water / Q000378:metabolism
D014867:Water