title: Fasting, but not adrenalectomy, reduces transport of leptin into the brain.
abstract: Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression analysis showed that fasting, but not ADX, significantly decreased the entry of leptin into mouse brain. After 3 days of food deprivation, the influx of leptin became indistinguishable from that of the vascular control (albumin); 5 h of refeeding significantly reversed this reduced rate of influx. Thus, the results indicate that the BBB provides a dynamic site for the regulation of physiological processes involving leptin.
authors.affiliation: Veterans Affairs Medical Center and Tulane University School of Medicine, 1601 Perdido Street, New Orleans, LA, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Kastin
authors.forename: V
authors.initials: V
authors.lastname: Akerstrom
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001692:Biological Transport; D001812:Blood-Brain Barrier; D005215:Fasting; D020738:Leptin / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D020738:Leptin