[Basic study on anti-bacterial urethral catheter. I. Development of a new anti-bacterial coating material for silicon catheters].
In order to develop a new anti-bacterial urethral catheter, we studied anti-bacterial and anti-adherent coating material suitable for silicon catheters. Several aspects of various silver compounds were examined, including anti-bacterial activity, chemical property and toxicity. Among silver citrate, silver phosphate and silver oxide, which were found to have excellent anti-bacterial activities, silver citrate was regarded as the material of choice for anti-bacterial coating in terms of durable activity and biological safety. It was also found that several surfactants inhibited bacterial adherence to the surface of silicon catheters. Among them soybean lecithin exhibited excellent anti-adherent activity in a dose dependent manner. Finally, a mixture of silver citrate, soybean lecithin and liquid silicon at the ratio of 2:2:8 was regarded as an ideal anti-bacterial coating material for silicon catheters.
Hashimoto
H
H
Department of Urology, Okayama University School of Medicine.
Ono
N
N
Monden
K
K
Kumon
H
H
Shiba
T
T
Adachi
T
T
Kaneko
K
K
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002404:Catheterization; D002951:Citrates; D004867:Equipment Design; D051379:Mice; D010713:Phosphatidylcholines / Q000494:pharmacology; D012825:Silicon; D012834:Silver / Q000494:pharmacology; D013501:Surface-Active Agents / Q000494:pharmacology*; D014521:Urethra; D014546:Urinary Catheterization / Q000295:instrumentation*
D002951:Citrates; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; D012834:Silver; D012825:Silicon