Rho GTPase signaling in inflammation and transformation.
Intracellular Rho GTPases provide an important regulatory mechanism to connect cell-surface-generated signals with the nucleus. By cycling between the active (guanosine 5'-triphosphate [GTP]) and inactive (guanosine 5'-diphosphate) state, these GTP-binding proteins control cellular functions ranging from dynamic actin remodeling and activation of transcription factors to cell-cycle progression and cellular transformation. Their contribution to these very diverse processes makes them an essential part of cell movement, growth, and apoptosis. Upstream regulatory mechanisms, as well as a variety of downstream effector molecules, enable Rho GTPases to act in a specific, orchestrated manner, dictating cellular responses. In this article, I review my laboratory's work centering on the goal of determining how specificity in intracellular signaling is achieved and identifying molecular mechanisms of Rho GTPase-mediated processes in innate immune and transformed cells.
Knaus
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Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. uknaus@scripps.edu
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D020741:rho GTP-Binding Proteins / Q000276:immunology*
D020741:rho GTP-Binding Proteins