[Ultrastructure study of hepatocellular carcinoma treated by diamminedichloroplatinum].
OBJECTIVE
To study the changes of the ultrastructure of hepatocellular carcinoma (HCC) after being treated by diamminedichloroplatinum.


METHODS
The changes of morphological feature of HCC treated by diamminedichloroplatinum were observed with transmission electron microscope.


RESULTS
The cells lost its specialized cell surface elements such as microvilli and cell-cell junctions. The nucleus chromatin condensed and segregated. The cytoplasm was hollow. The ribosomes on the endoplasmic reticulum reduced or lacked. The glycogen granules reduced. The mitochondria vacuolalized or produced flocculi, and the apoptotic bodies could be found.


CONCLUSIONS
The changes of the ultrastructure of HCC treated by diamminedichloroplatinum correspond with the procedure of programmed cell death. Apoptosis of HCC cells can be induced by diamminedichloroplatinum.
Wei
C
C
Cancer Hospital, Guangxi Medical University, Nanning 530021, China.
Chen
J
J
Liu
J
J
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
D000970:Antineoplastic Agents; D002945:Cisplatin