Two consecutive pregnancies during inadvertent gonadotropin-releasing hormone agonist desensitization.
OBJECTIVE
To describe two consecutive spontaneous pregnancies during luteal-phase down-regulation with a GnRH-a.


METHODS
Case report.


METHODS
University-affiliated reproductive medicine unit.


METHODS
A 33-year-old woman with a history of failed uterine tubal reanastomosis.


METHODS
Four IVF cycles.


METHODS
Pregnancy.


RESULTS
The patient had two spontaneous pregnancies during luteal-phase down-regulation.


CONCLUSIONS
Although midluteal administration of GnRH-a is not established as a treatment, there might be a beneficial effect on the endometrium via the medication's evoked gonadotropin flare.
Platteau
P
P
Monash-IVF, Epworth Hospital, Melbourne, Victoria, Australia. peter.platteau@az.vub.ac.be
Gabbe
M
M
Talbot
M
M
Healy
D
D
D000328:Adult; D015536:Down-Regulation; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008183:Luteal Phase; D011247:Pregnancy / Q000187:drug effects
D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide