Dynamical behaviour of viral cycle and identification of steady states.
The molecular biology of viruses can be effectively described by kinetic logic as several feedback loops are implicated in all viral cycles and as viral proteins generally display several functions. We applied this method to the study of the rhabdovirus cycle. Formally, the dynamics of the model are explored on the basis of a discrete caricature (kinetic logic), with special emphasis on the role of the constitutive feedback loops to determine the essential dynamical behaviour of the viral cycle. From a biological point of view, our model accounts for several stable regimes or attractors: healthy cells, acute infection and different kinds of persistent infections, a multistationarity in good agreement with the existence of several positive feedback loops in our system.
Martinet-Edelist
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C
CNRS, Gif/Yvette, France. edelist@gv.cnrs-gif.fr
D000818:Animals; D005246:Feedback; D006801:Humans; D008957:Models, Genetic; D012209:Rhabdoviridae / Q000235:genetics / Q000502:physiology*; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology*; D016662:Virus Integration / Q000235:genetics / Q000502:physiology; D014779:Virus Replication / Q000235:genetics / Q000502:physiology*
D014764:Viral Proteins