title: Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists.
abstract: Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependent on ring size and the position of the sulfur atom.
authors.affiliation: Roche Research Center, Hoffmann-La Roche Inc, Nutley, NJ 07110, USA. nader.fotouhi@roche.com
authors.forename: N
authors.initials: N
authors.lastname: Fotouhi
authors.forename: P
authors.initials: P
authors.lastname: Joshi
authors.forename: J W
authors.initials: JW
authors.lastname: Tilley
authors.forename: K
authors.initials: K
authors.lastname: Rowan
authors.forename: V
authors.initials: V
authors.lastname: Schwinge
authors.forename: B
authors.initials: B
authors.lastname: Wolitzky
mesh_terms: D039041:Integrin alpha4beta1; D016023:Integrins / Q000037:antagonists & inhibitors*; D018716:Molecular Mimicry; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D016201:Receptors, Lymphocyte Homing / Q000037:antagonists & inhibitors*; D013440:Sulfides / Q000737:chemistry*; D019010:Vascular Cell Adhesion Molecule-1 / Q000187:drug effects*
chemical_list: D039041:Integrin alpha4beta1; D016023:Integrins; D010456:Peptides, Cyclic; D016201:Receptors, Lymphocyte Homing; D013440:Sulfides; D019010:Vascular Cell Adhesion Molecule-1