Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 6. Synthesis of a key intermediate via a highly efficient macrolactonization of computer-aid designed seco-acid.
Matsushima
T
T
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Nakajima
N
N
Zheng
B Z
BZ
Yonemitsu
O
O
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003198:Computer Simulation; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D000970:Antineoplastic Agents; D018942:Macrolides