[Effects of dietary phosphorus restriction on the production of 1,25(OH)2D3 (calcitriol) in patients with moderated renal failure].
Calcitriol deficiency and phosphate retention are two main factors in the pathogenesis of renal hyperparathyroidism. In spite of normal serum levels, phosphate may have an important role even in moderate RI. The aim of this study was to evaluate the effect of dietary phosphorus restriction on serum levels of calcitriol in patients with moderate RI. We studied 21 patients (7 F/14 M); mean age 61.7 +/- 15 years old; corrected creatinine clearance 51.4 +/- 14 ml/m. Serum PTH, calcitriol 25(OH)D3, calcium, phosphorus and urinary excretion of calcium and phosphorus were measured before and after 30 days on phosphorus restricted diet (700 mg/day).


RESULTS
[table: see text]


CONCLUSIONS
Our patients with moderate RI have elevated serum levels of PTH while calcitriol was in the lower normal range. Dietary phosphorus restriction resulted in a significant decrease in PTH levels and a significant increase in serum calcitriol concentrations. The levels of 25(OH)D3 did not change in this study.
Amor
J
J
Servicio de Nefrología, Hospital Universitario Virgen Macarena, Sevilla.
Aresté
N
N
Cambil
T
T
de la Prada
F
F
Jarava
C
C
Salgueira
M
M
Páez
M C
MC
Sánchez-Palencia
R
R
Palma
A
A
D002117:Calcitriol / Q000096:biosynthesis*; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000008:administration & dosage*; D051437:Renal Insufficiency / Q000378:metabolism*; D012720:Severity of Illness Index
D010758:Phosphorus; D002117:Calcitriol
Efectos de una restricción de fósforo dietético en la producción de 1,25(OH)2D3 (calcitriol) en pacientes con insuficiencia renal moderada.