An autosomal genomic scan for loci linked to plasma leptin concentration in Pima Indians.
OBJECTIVE
To identify chromosomal regions linked to plasma leptin concentrations.


METHODS
Autosomal genome-wide scan, including 516 microsatellite markers. Sib-pair (Haseman-Elston) and variance components methods were used to assess genetic linkage.


METHODS
770 Pima Indians comprising 239 nuclear families (for a total of 1199 sibling-pairs).


METHODS
Plasma leptin concentrations and body mass index (BMI), adjusted for age and sex.


RESULTS
The strongest evidence for linkage with plasma leptin concentration was on chromosome 6p logarithm of odds (LOD) = 2.1 by variance components analysis). There was no evidence for linkage to BMI in this region. Additional regions with marginal evidence for linkage to plasma leptin concentration (LOD > or =1.0) were detected on chromosomes 3, 11, 13, 15 and 16.


CONCLUSIONS
The results suggest that a locus on chromosome 6p influences plasma leptin concentrations. Replication studies are needed to exclude the possibility that linkage has been falsely detected.
Walder
K
K
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.
Hanson
R L
RL
Kobes
S
S
Knowler
W C
WC
Ravussin
E
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003920:Diabetes Mellitus / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D020738:Leptin / Q000097:blood*; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009765:Obesity / Q000235:genetics
D020738:Leptin