title: Developmental instability and schizotypy.
abstract: BACKGROUND
  It has been suggested that evidence of developmental disturbance of cognition and lateralisation in schizophrenia can be best understood from the perspective of developmental stability (DS), an indicator of the extent to which an individual develops according to a specified ontogenic programme in the presence of environmental noise. Higher levels of fluctuating asymmetry (FA; the difference between right and left side of a quantitative morphological trait such as dermatoglyphics) are thought to reflect less DS. We examined this issue for dimensions of schizotypy.
  
  
  METHODS
  Associations between FA, measures of laterality and cognitive function on the one hand, and negative and positive dimensions of schizotypy on the other, were examined in a sample of 260 healthy adolescents aged 11.9-15.6years. FA was measured as a-b ridge count right-left differences. Neuropsychological measures yielded a general cognitive ability score and a frontal function score. Laterality was assessed with the Annett scale.
  
  
  RESULTS
  Measures of psychosis proneness were normally distributed. Negative schizotypy was associated with more FA and lower general cognitive ability in a dose-response fashion. The association with FA was more apparent in boys. No associations existed with laterality or frontal function.
  
  
  CONCLUSIONS
  The negative dimension of schizotypy may be associated with early developmental instability, resembling the pattern seen in the negative symptom dimension of schizophrenia. Measures of fluctuating asymmetry may be more sensitive with regard to the schizotypy phenotype than measures of laterality.
authors.affiliation: Laboratori d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Rosa
authors.forename: J
authors.initials: J
authors.lastname: van Os
authors.forename: L
authors.initials: L
authors.lastname: Fañanás
authors.forename: N
authors.initials: N
authors.lastname: Barrantes
authors.forename: B
authors.initials: B
authors.lastname: Caparrós
authors.forename: B
authors.initials: B
authors.lastname: Gutiérrez
authors.forename: J
authors.initials: J
authors.lastname: Obiols
mesh_terms: D000293:Adolescent; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D002658:Developmental Disabilities / Q000175:diagnosis / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D009483:Neuropsychological Tests; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000503:physiopathology*; D013030:Spain