title: Modulation of chemotaxis, O(2)(-) production and myeloperoxidase release from human polymorphonuclear leukocytes by the ornithine-containing lipid and the serineglycine-containing lipid of Flavobacterium.
abstract: The ornithine-containing lipid (OL) and the serineglycine-containing lipid (SGL) of Flavobacterium activated and modulated the functions of human polymorphonuclear leukocytes (PMNs). The OL and the SGL strongly activated fMet-Leu-Phe- and interleukin-8-induced chemotaxis of PMNs at the concentration of 0.1 microg ml(-1), and a synthetic OL also activated the function of PMNs. Further, the OL strongly activated O(2)(-) production from PMNs. Although the OL and the SGL slightly modulated myeloperoxidase release from PMNs, inhibition effects of their component fatty acid analogues were observed. O(2)(-) production-inducing activity is a common biological activity between the OL and bacterial lipopolysaccharides, but OL and SGL, unlike lipopolysaccharide, are potent activators of PMN chemotaxis.
authors.affiliation: Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kawai
authors.forename: A I
authors.initials: AI
authors.lastname: Okawarab
authors.forename: H
authors.initials: H
authors.lastname: Okuyama
authors.forename: F
authors.initials: F
authors.lastname: Kura
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005417:Flavobacterium; D005998:Glycine / Q000032:analysis / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000737:chemistry / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009952:Ornithine / Q000032:analysis / Q000494:pharmacology; D009195:Peroxidase / Q000378:metabolism*; D012694:Serine / Q000032:analysis / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*
chemical_list: D008055:Lipids; D013481:Superoxides; D012694:Serine; D009952:Ornithine; D009195:Peroxidase; D005998:Glycine