[Hydrolase from Xanthomonas rubrilineans for synthesis of cefalexin].
The use of peptide hydrolase (EC 3.4.13.1) from Xanthomonas rubrilineans for synthesis of the antibiotic cephalexin from 7-aminodesacetoxycephalosporanic acid was studied. The optimum conditions for production of cephalexin were determined, and the yield exceeded 80%. A method for monitoring the synthesis of this antibiotic synthesis by means of a conventional amino acid analyzer is proposed.
Ivankin
A N
AN
Moscow State University of Forestry, Mytishchi, Russia.
Nekliudov
A D
AD
D002506:Cephalexin / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism; D006867:Hydrolases / Q000378:metabolism*; D014974:Xanthomonas / Q000201:enzymology*
D002511:Cephalosporins; C014320:7-aminodesacetoxycephalosporanic acid; D006867:Hydrolases; D002506:Cephalexin
Gidrolaza iz Xanthomonas rubrilineans dlia sinteza tsefaleksina.