title: Oxaliplatin, 5-fluorouracil, and folinic acid (Folfox) in patients with metastatic renal cell carcinoma: results of a pilot study.
abstract: We report the results of a chemotherapy regimen combining oxaliplatin, 5-fluorouracil, and folinic acid in patients with metastatic renal cell carcinoma. The objective of this pilot study was to define the potential efficacy of this second-line combination in patients previously treated with interleukin-2 alone or in combination with interferon alpha. Fourteen patients with metastatic renal cell carcinoma in failure after immunotherapy were included in this trial. During treatment, patients received six chemotherapy courses (Folfox regimen) administered every 2 weeks. Each cycle combined oxaliplatin day (D) D1 and folinic acid plus 5-fluorouracil D1 and D2. At completion of treatment, no objective response was observed and two patients presented stable disease. This chemotherapy schedule in patients with metastatic renal cell carcinoma previously treated with immunotherapy does not seem to be effective.
authors.affiliation: Oncology Unit, Laennec Hospital, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Chaouche
authors.forename: A L
authors.initials: AL
authors.lastname: Pasturaud
authors.forename: D
authors.initials: D
authors.lastname: Kamioner
authors.forename: M
authors.initials: M
authors.lastname: Grandjean
authors.forename: J
authors.initials: J
authors.lastname: Franiatte
authors.forename: J M
authors.initials: JM
authors.lastname: Tourani
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy; D016898:Interferon-alpha / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds; D010865:Pilot Projects; D011379:Prognosis
chemical_list: D016898:Interferon-alpha; D007376:Interleukin-2; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil