title: Effect of internal wool lipid liposomes on skin repair.
abstract: Intercellular lipids of the stratum corneum (SC) play a crucial role in keeping an optimal skin barrier function and in regulating the water-holding capacity. Recently, the internal lipids have been extracted from wool fibre. This lipid extract has a composition similar to that of the SC lipids. Two parameters were used to test the effect of topically applied internal wool lipids (IWL), structured as liposomes, on the water barrier functions of disturbed and intact skin: transepidermal water loss and skin capacitance. Liposomes made up of lipids that simulate the composition of the SC were also applied for comparison. The single application of the IWL liposomes on disturbed skin resulted in an accelerated recovery of water barrier functions. Daily application of these liposomes on intact skin for 5 days reinforced the skin barrier and increased the water-holding capacity. The repairing effect of the IWL enhances their suitability in the treatment, prevention and care of skin.
authors.affiliation: Instituto de Investigaciones Químicas y Ambientales de Barcelona (IIQAB), CSIC, Barcelona, España. mplesl@cid.csic.es
authors.forename: M
authors.initials: M
authors.lastname: de Pera
authors.forename: L
authors.initials: L
authors.lastname: Coderch
authors.forename: J
authors.initials: J
authors.lastname: Fonollosa
authors.forename: A
authors.initials: A
authors.lastname: de la Maza
authors.forename: J L
authors.initials: JL
authors.lastname: Parra
mesh_terms: D000328:Adult; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D015824:Blood-Air Barrier / Q000187:drug effects; D005260:Female; D006801:Humans; D008055:Lipids / Q000494:pharmacology*; D008081:Liposomes / Q000494:pharmacology*; D008297:Male; D012867:Skin / Q000737:chemistry / Q000187:drug effects*; D014867:Water / Q000737:chemistry; D014870:Water Loss, Insensible / Q000187:drug effects; D014935:Wool / Q000737:chemistry*
chemical_list: D008055:Lipids; D008081:Liposomes; D014867:Water