title: Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis.
abstract: Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.
authors.affiliation: Department of Neurology, Bayerische Julius-Maximilians- University, Wuerzburg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Giess
authors.forename: M
authors.initials: M
authors.lastname: Naumann
authors.forename: E
authors.initials: E
authors.lastname: Werner
authors.forename: R
authors.initials: R
authors.lastname: Riemann
authors.forename: M
authors.initials: M
authors.lastname: Beck
authors.forename: I
authors.initials: I
authors.lastname: Puls
authors.forename: C
authors.initials: C
authors.lastname: Reiners
authors.forename: K V
authors.initials: KV
authors.lastname: Toyka
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000187:drug effects*; D011446:Prospective Studies; D012798:Sialorrhea / Q000188:drug therapy*
chemical_list: D019274:Botulinum Toxins, Type A