title: One versus two intracavitary brachytherapy applications in early-stage cervical cancer patients undergoing definitive radiation therapy.
abstract: OBJECTIVE
  The purpose of this study was to compare the outcomes of early stage cervical cancer patients undergoing definitive radiation therapy (RT) with one versus two low-dose-rate intracavitary brachytherapy (ICB) applications.
  
  
  METHODS
  Between 1983 and 1993, 140 stage IB-IIA patients underwent whole-pelvis RT (WPRT) and ICB. Prior to 1988, 56 patients (40%) received two ICB applications. After 1988, our policy was modified and subsequently 84 (60%) patients underwent one application. Patient, tumor, and treatment characteristics, outcome, and complications of the two groups were compared.
  
  
  RESULTS
  The groups were balanced in terms of race, hemoglobin level, histology, grade, treatment duration, chemotherapy, and follow-up. The single-application group, however, had more stage IB disease, had small (< or =4 cm) tumors, and received higher WPRT and lower point A doses. Overall, the two groups had similar 5-year local control (P = 0.83) and disease-free (P = 0.23) and cause-specific (P = 0.29) survival rates. Moreover, no differences were seen when analyzed by tumor size or stage. On multivariate analysis, the number of applications was not correlated with recurrence (P = 0.59, hazard rate = 1.1, 95% confidence interval = 0.6-2.2). Chronic complications were similar in the two groups.
  
  
  CONCLUSIONS
  Our nonselected comparison of one versus two ICB applications in early-stage cervical cancer patients reveals comparable outcomes and complication rates for the two approaches. These results support the use of a single application in early-stage patients undergoing definitive RT.
authors.affiliation: Department of Radiation and Cellular Oncology, University of Chicago Hospitals, IL 60637, USA. jrotmens@babies.bsd.uchicago.edu
authors.forename: J
authors.initials: J
authors.lastname: Rotmensch
authors.forename: P P
authors.initials: PP
authors.lastname: Connell
authors.forename: D
authors.initials: D
authors.lastname: Yamada
authors.forename: S E
authors.initials: SE
authors.lastname: Waggoner
authors.forename: A J
authors.initials: AJ
authors.lastname: Mundt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*