title: Response to alcohol in daughters of alcoholics: a pilot study and a comparison with sons of alcoholics.
abstract: Drinking, but not alcohol-dependent, 18-29-year-old daughters of alcoholics (n = 38) from the Collaborative Study on the Genetics of Alcoholism were compared to 75 family-history-positive (FHP) men from the same families, and 68 family-history-negative (FHN) male controls. Subjects received 0.75 ml/kg of ethanol (for women), 0.9 ml/kg of ethanol (for men), and placebo, each of which was consumed over 8 min on different occasions. The breath-alcohol concentrations (BrAC) and reactions to alcohol [using the Subjective High Assessment Scale (SHAS) and body sway measures] were evaluated over 210 min. The results indicate that, despite slightly higher BrAC values for the FHP men, on the SHAS the FHP women and the FHP men demonstrated significantly lower scores than the FHN male controls, although the values for FHP men and women did not differ. On body sway, the FHP men showed evidence of less alcohol-related increases than FHN men, and there was a trend in the same direction for FHP women, but only early in the session (e.g. at 60 min). Pilot data for 11 FHN women revealed higher scores for both SHAS and body sway at 60 min, compared to FHP women, but, perhaps reflecting the small number of subjects, the family history differences were not significant. Overall, the results in FHP women resemble those for FHP men, and suggest that a low level of response to alcohol might also be a characteristic of daughters of alcoholics.
authors.affiliation: Department of Psychiatry, Veterans Affairs San Diego Healthcare System, CA 92161-2002, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Schuckit
authors.forename: T L
authors.initials: TL
authors.lastname: Smith
authors.forename: J
authors.initials: J
authors.lastname: Kalmijn
authors.forename: J
authors.initials: J
authors.lastname: Tsuang
authors.forename: V
authors.initials: V
authors.lastname: Hesselbrock
authors.forename: K
authors.initials: K
authors.lastname: Bucholz
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000235:genetics* / Q000503:physiopathology; D000437:Alcoholism / Q000235:genetics* / Q000503:physiopathology; D000704:Analysis of Variance; D001944:Breath Tests; D005260:Female; D005684:Gait; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009679:Nuclear Family; D010865:Pilot Projects; D012737:Sex Factors