title: [Intraepithelial carcinoma and invasive carcinoma of the vulva, vagina and penis in Ile-de-france. Enquete PETRI on 423 cases].
abstract: OBJECTIVE
  Precancerous and invasive carcinoma of the external genitalia and of the vagina are rare tumors and their incidence is not very well known in the Paris region. The objective of this study was to evaluate the frequency of precancerous and invasive lesions of the vulva, the vagina and the penis as well as their variation according to age.
  
  
  METHODS
  A prospective study was conducted implicating private and public pathology laboratories in Paris and the seven departments around. Four hundred and twenty three genital biopsies have been analyzed: 160 from the vulva, 151 from the vagina and 112 from the penis.
  
  
  RESULTS
  The mean age of the patients was 45 years. The highest frequency of genital biopsies was similar for the three anatomical sites and concerned patients of 25-34 years old. intraepithelial neoplasias represented 77p. 100 of the biopsies (32p. 100 of low grade and 45p. 100 of high grade), invasive squamous carcinoma and adenocarcinoma represented 21p. 100 and 2p. 100 of cases, respectively. The mean age of the patients with low grade vulvar intraepithelial neoplasia, low grade vaginal intraepithelial neoplasia and low grade penile intraepithelial were 34, 40 and 33 years old, respectively. An interval of three to seven years separates the mean age of low grade intraepithelial neoplasia from the mean age of high grade. High grade intraepithelial neoplasia present a peak of frequency in the same class of age for the three localizations (25-34 years) and the risk of developing a high grade intraepithelial neoplasia of the external genital was higher between 25 and 35 years and between 35-45 years of the vagina. The mean age of invasive vulvar carcinoma, vagina carcinoma and penile carcinoma was 62, 59 and 68 years old, respectively.
  
  
  CONCLUSIONS
  The correlation between the development of intraepithelial neoplasia of the vulva and the penis supposes a common aetiologic factor in the majority of the cases. The diagnosis of a intraepithelial neoplasia implies a clinical, colposcopic and follow-up of the entire genital area.
authors.affiliation: Prévention et Epidémiologie des Tumeurs en Région Ile-de-France (PETRI), 60, boulevard de Latour-Maubourg, 75007 Paris.
authors.forename: O
authors.initials: O
authors.lastname: Aynaud
authors.forename: B
authors.initials: B
authors.lastname: Asselain
authors.forename: C
authors.initials: C
authors.lastname: Bergeron
authors.forename: I
authors.initials: I
authors.lastname: Cartier
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.forename: X
authors.initials: X
authors.lastname: Sastre-Garau
authors.forename: M
authors.initials: M
authors.lastname: Souques
authors.forename: K
authors.initials: K
authors.lastname: Zummer
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D002277:Carcinoma / Q000453:epidemiology*; D002278:Carcinoma in Situ / Q000453:epidemiology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D003127:Colposcopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010297:Paris / Q000453:epidemiology; D010412:Penile Neoplasms / Q000453:epidemiology*; D011230:Precancerous Conditions / Q000453:epidemiology; D011446:Prospective Studies; D012307:Risk Factors; D014625:Vaginal Neoplasms / Q000453:epidemiology*; D014846:Vulvar Neoplasms / Q000453:epidemiology*
vernacular_title: Carcinomes intraépithéliaux et carcinomes invasifs de la vulve, du vagin et du pénis en Ile-de-France. Enquête PETRI portant sur 423 cas.