title: Effects of acidosis on the post-hypoxic recovery of synaptic transmission in gerbil hippocampal slices.
abstract: We investigated the effects of acidosis on the hypoxic neuronal damage using gerbil hippocampal slices. Acidosis has delayed the onset of harmful hypoxic depolarization, resulting in a decrease in the total hypoxic period and the hypoxic depolarization. This effect has been considered to be protective. However, the synaptic recovery after reoxygenation was attenuated when acidosis (pH: 6.2-6.9) was sustained. Conversely, the synaptic recovery was potentiated when the acidosis was restored to the physiological milieu during the reoxygenation period. These results suggest that acidosis plays a protective effect against the hypoxic neuronal damage only when rapid appreciable pH recovery is achieved during reoxygenation.
authors.affiliation: Department of Neurosurgery, Nara Medical University, 840 Shijou-cho, Nara 634-8522, Kashihara, Japan. zan14530@nifty.ne.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Kamada
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: T
authors.initials: T
authors.lastname: Sakaki
mesh_terms: D000138:Acidosis / Q000503:physiopathology*; D000818:Animals; D001831:Body Temperature / Q000502:physiology; D005849:Gerbillinae; D005947:Glucose / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000503:physiopathology*; D066298:In Vitro Techniques; D009410:Nerve Degeneration / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*; D013997:Time Factors
chemical_list: D005947:Glucose; D010100:Oxygen