T cell memory: heterogeneity and mechanisms.
Immunological memory is manifested by the body's ability to enjoy long-term protection against specific pathogens previously encountered through illness or vaccination. This memory response resides in the long-lived, previously activated memory T and B lymphocytes that are believed to exist in a quiescent state. Recent advances in studies on T cell memory have revealed heterogeneity in the T cells that mediate memory responses that may have implications for the generation and maintenance of these cells over time. This review will present these recent findings on memory T cells in the context of past research and current models for the generation and persistence of memory T cells.
Farber
D L
DL
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park 20742, USA. df92@umail.umd.edu
D000818:Animals; D018740:Genetic Heterogeneity; D006801:Humans; D007156:Immunologic Memory / Q000235:genetics / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*