title: Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor.
abstract: Four of 10 patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony-stimulating factor. There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.
authors.affiliation: Department of Neurology, City of Hope National Medical Center, Duarte, CA 91010, USA. hopenshaw@coh.org
authors.forename: H
authors.initials: H
authors.lastname: Openshaw
authors.forename: O
authors.initials: O
authors.lastname: Stuve
authors.forename: J P
authors.initials: JP
authors.lastname: Antel
authors.forename: R
authors.initials: R
authors.lastname: Nash
authors.forename: B T
authors.initials: BT
authors.lastname: Lund
authors.forename: L P
authors.initials: LP
authors.lastname: Weiner
authors.forename: A
authors.initials: A
authors.lastname: Kashyap
authors.forename: P
authors.initials: P
authors.lastname: McSweeney
authors.forename: S
authors.initials: S
authors.lastname: Forman
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D010243:Paralysis / Q000139:chemically induced / Q000188:drug therapy; D011994:Recombinant Proteins
chemical_list: D000893:Anti-Inflammatory Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D008775:Methylprednisolone