How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies.
The epsilon 4 allele of apolipoprotein E is a risk factor for Alzheimer's disease, but also a modulator of its clinical picture. In this paper, recent research in neuroimaging of aging and Alzheimer's disease in relation to apolipoprotein E is reviewed, emphasizing the advances but also the controversies. Further, the possible clinicopathological implications of these findings are discussed.
Lehtovirta
M
M
Department of Neurology, Kuopio University Hospital, P.O. Box 1777, 70211, Kuopio, Finland. maarit.lehtovirta@ktl.fi
Laakso
M P
MP
Frisoni
G B
GB
Soininen
H
H
D000375:Aging / Q000473:pathology / Q000502:physiology*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology*; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D011877:Radionuclide Imaging
D001057:Apolipoproteins E