LTP mechanisms: from silence to four-lane traffic.
Brief periods of strong neuronal activity induce long-lasting changes in synaptic function. This synaptic plasticity is thought to play important roles in learning and memory. One example--long-term potentation in the CA1 region of the hippocampus--has been studied extensively, and conflicting views regarding the underlying mechanisms have emerged. Recent findings, regarding basic properties of synaptic transmission, appear to reconcile these diverging views.
Malinow
R
R
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. malinow@cshl.org
Mainen
Z F
ZF
Hayashi
Y
Y
D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*