title: Combinatorial chemistry and contemporary pharmacology.
abstract: Both solid- and liquid-phase combinatorial chemistry have emerged as powerful tools for identifying pharmacologically active compounds and optimizing the biological activity of a lead compound. Complementary high-throughput in vitro assays are essential for compound evaluation. Cell-based assays that use optical endpoints permit investigation of a wide variety of functional properties of these compounds including specific intracellular biochemical pathways, protein-protein interactions, and the subcellular localization of targets. Integration of combinatorial chemistry with contemporary pharmacology now represents an important factor in drug discovery and development.
authors.affiliation: Departments of Pharmacology and Chemistry, University of Pittsburgh, PA 15261, USA. lazo+@pitt.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Lazo
authors.forename: P
authors.initials: P
authors.lastname: Wipf
mesh_terms: D020650:Combinatorial Chemistry Techniques; D019151:Peptide Library; D010600:Pharmacology
chemical_list: D019151:Peptide Library