Unaltered alpha(2)-noradrenergic/imidazoline receptors in suicide victims: a postmortem brain autoradiographic analysis.
In vitro quantitative autoradiography of alpha(2)-adrenergic/imidazoline receptors, using [(125)I]iodoclonidine as a ligand, was performed on 24 human brains postmortem. Twelve brains were obtained from suicide victims and 12 from matched controls. We found no significant, region-dependent alterations in the density of alpha(2)-adrenergic receptors in brains of suicide victims as compared to matched controls. We also report age-dependent reductions in binding in the prefrontal cortex and hippocampus, as well as significant recent alcohol ingestion-dependent reductions in binding in the prefrontal cortex. Sex and time from death to autopsy did not affect iodoclonidine binding in our sample.
Gross-Isseroff
R
R
Department of Neurobiology, The Weizman Institute of Science, 76100, Rehovot, Israel. bmruth@weizmann.weizmann.ac.il
Weizman
A
A
Fieldust
S J
SJ
Israeli
M
M
Biegon
A
A
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001345:Autoradiography; D001921:Brain / Q000000981:diagnostic imaging*; D001923:Brain Chemistry; D005260:Female; D006801:Humans; D054755:Imidazoline Receptors; D008297:Male; D008875:Middle Aged; D011180:Postmortem Changes; D011859:Radiography; D018341:Receptors, Adrenergic, alpha-2 / Q000032:analysis*; D011955:Receptors, Drug / Q000032:analysis*; D012737:Sex Factors; D013405:Suicide; D013997:Time Factors
D054755:Imidazoline Receptors; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug