title: The Drosophila dominant wing mutation Dichaete results from ectopic expression of a Sox-domain gene.
abstract: The dominant Drosophila wing mutation Dichaete is characterised by the deletion of proximal wing structures. By analysing a number of new Dichaete alleles, phenotypic revertants and enhancer piracy lines, we show that the wing phenotype results from ectopic expression of the Sox-domain gene Dichaete. Ectopic expression of the Sox gene results in an increase in cell death in the proximal region of the wing imaginal disc and leads to alterations in the normal expression of wingless. Since ectopic expression of wingless in the proximal region of the wing disc can rescue aspects of the Dichaete phenotype, it is likely that Dichaete specifically interferes with the establishment or maintenance of a critical domain of wingless expression in the wing disc.
authors.affiliation: Department of Genetics, University of Cambridge, UK. s.russell@gen.cam.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Russell
mesh_terms: D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins; D004330:Drosophila / Q000033:anatomy & histology / Q000235:genetics*; D029721:Drosophila Proteins; D006579:Heterozygote; D006609:High Mobility Group Proteins / Q000235:genetics* / Q000378:metabolism; D007814:Larva; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics; D055747:SOX Transcription Factors; D014157:Transcription Factors / Q000235:genetics; D014921:Wings, Animal; D051155:Wnt1 Protein
chemical_list: C103073:D protein, Drosophila; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D006609:High Mobility Group Proteins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D055747:SOX Transcription Factors; D014157:Transcription Factors; D051155:Wnt1 Protein; C074622:wg protein, Drosophila