Sequence analyses of the olfactory receptor gene cluster mOR37 on mouse chromosome 4.
The olfactory receptor multigene family is organized in clusters spread throughout the genome. In the present study, we have sequenced two subregions of the mOR37 gene cluster on mouse chromosome 4. The resulting 100 kb of sequence revealed seven odorant receptor coding regions and one gene fragment. Sequence analyses reveal that the mOR37 gene cluster may represent a rather ancient cluster. The mOR37 genes exhibit a complex intron/exon structure, and some appear to be differentially spliced. All genes in the cluster share conserved sequence motifs 5' of their putative initial exons, which represent potential binding sites for transcription factors. The clustered organization and conserved sequence motifs suggest common expression control mechanisms for these genes.
Hoppe
R
R
Institute of Physiology, University of Hohenheim, Garbenstrasse 30, Stuttgart, D-70593, Germany.
Weimer
M
M
Beck
A
A
Breer
H
H
Strotmann
J
J
D020121:5' Untranslated Regions; D000818:Animals; D001482:Base Composition; D002875:Chromosomes / Q000235:genetics*; D017124:Conserved Sequence; D016208:Databases, Factual; D020440:Gene Duplication; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D015530:Nuclear Matrix / Q000235:genetics; D016366:Open Reading Frames / Q000235:genetics; D020161:Physical Chromosome Mapping; D018035:Receptors, Odorant / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
D020121:5' Untranslated Regions; D018035:Receptors, Odorant