Combination antifungal therapy in treatment of murine pulmonary mucormycosis: roles of quinolones and azoles.
Amphotericin B is the only recognized antifungal used in the treatment of mucormycosis. In this study, we evaluated various combinations of amphotericin B, fluconazole, and trovafloxacin or ciprofloxacin in the treatment of murine pulmonary mucormycosis. The combination of fluconazole and a quinolone has a marked effect on the outcome of murine pulmonary mucormycosis. Even though we did not optimize therapy with the drugs, these experiments suggest that azoles, especially fluconazole, in combination with either trovafloxacin or ciprofloxacin were effective in the treatment of this aggressive mycosis in the mouse model.
Sugar
A M
AM
Evans Memorial Department of Clinical Research and Department of Medicine, Boston Medical Center, Boston, Massachusetts 02118, USA. asugar@medicine.bu.edu
Liu
X P
XP
D042462:4-Quinolones; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D015725:Fluconazole / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009091:Mucormycosis / Q000188:drug therapy* / Q000401:mortality; D012233:Rhizopus / Q000187:drug effects; D016896:Treatment Outcome
D042462:4-Quinolones; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D015725:Fluconazole