What is the benefit of preoperative sperm preservation for patients who undergo restorative proctocolectomy for benign diseases?
OBJECTIVE
In patients with benign colorectal diseases undergoing a restorative proctocolectomy with an ileal pouch-anal anastomosis, semen cryopreservation seems rational to enable the possibility of procreation in case surgery leads to sexual disorders or impotence. The aim of this study was to determine the preoperative and postoperative semen quality in patients undergoing ileal pouch-anal anastomosis. In addition, the study sought to determine the incidence of surgery-induced sexual dysfunction to evaluate the economic efficiency of semen cryopreservation as compared with alternatives such as microsurgical epididymal sperm aspiration.


METHODS
Preoperative and postoperative semen analyses were offered to 97 patients with ileal pouch-anal anastomosis with benign colorectal diseases since 1989. The direct costs of the semen cryopreservation program were determined and compared with those of alternatives.


RESULTS
In 34 of 40 consecutive patients with ileal pouch-anal anastomosis who made use of preoperative semen preservation, normal sperm concentrations, motility, and morphology were found. Mean semen characteristics of all 23 patients who returned for postoperative analysis were not different from preoperative values, but they were for total sperm number. Two patients developed temporary retrograde ejaculation postoperatively. None of the preserved semen samples was used, thus semen cryopreservation benefited none of these patients. The total costs of semen cryopreservation are between 2.2 and 5 times higher than the costs for one microsurgical epididymal sperm aspiration procedure.


CONCLUSIONS
Preoperative semen cryopreservation in patients undergoing ileal pouch-anal anastomosis because of benign colorectal diseases is quite feasible. However, most likely because of improved surgical techniques and the increasing number of effective alternatives, preoperative semen cryopreservation in patients with ileal pouch-anal anastomosis is no longer cost effective.
van Duijvendijk
P
P
Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
Slors
J F
JF
Taat
C W
CW
van Lochem
L T
LT
Bonsel
G J
GJ
de Vries
J W
JW
Obertop
H
H
D000328:Adult; D003108:Colonic Diseases / Q000601:surgery*; D015925:Cryopreservation; D004542:Ejaculation; D006801:Humans; D008297:Male; D011184:Postoperative Period; D016737:Proctocolectomy, Restorative / Q000009:adverse effects; D012002:Rectal Diseases / Q000601:surgery*; D012661:Semen; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000502:physiology*