title: Development. PARallels in axis formation.
abstract: There is an intricate network of molecules called cell fate determinants that instruct the cells of the embryo to take on either an anterior or posterior fate. In a lively Perspective, Lehmann and her colleagues discuss new findings in the fruit fly that identify a key protein, PAR-1, which ensures that the cell fate determinants are themselves located in the correct region of the oocyte. In this way, the anterior-posterior axis is set up in the fruit fly egg before fertilization.
authors.affiliation: Developmental Genetics Program, Skirball Institute, Howard Hughes Medical Institute, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
authors.forename: J
authors.initials: J
authors.lastname: Morris
authors.forename: R
authors.initials: R
authors.lastname: Lehmann
authors.forename: C
authors.initials: C
authors.lastname: Navarro
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology; D000818:Animals; D019521:Body Patterning; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics / Q000502:physiology; D016764:Cell Polarity; D018385:Centrosome / Q000502:physiology; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D008870:Microtubules / Q000502:physiology; D009154:Mutation; D009865:Oocytes / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators; C056478:bcd protein, Drosophila; C091675:osk protein, Drosophila; C069927:stau protein, Drosophila; D017346:Protein Serine-Threonine Kinases