Improvement of cystic fibrosis using antitumoral drugs: a hypothesis.
The improvement of cystic fibrosis using antitumoral drugs has been reported. The hypothesis of a somatic reduction to heterozygosity of the CFTR gene mutations by homologous recombination in lung epithelium is proposed.
Faivre
L
L
Département de Génétique, Hôpital Necker Enfants-Malades, Paris, 75015, France.
Bonnefont
J P
JP
Lyonnet
S
S
Munnich
A
A
Vekemans
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D018528:ATP-Binding Cassette Transporters / Q000235:genetics; D000328:Adult; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000235:genetics; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects; D006579:Heterozygote; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D000970:Antineoplastic Agents; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C505032:CFTR protein, human