[Genome analysis of pathogenic bacteria--a review].
The whole genome information on pathogenic bacteria opened a new era of medical microbiology. Bacteria have a variety of strategies to survive in human body against host defense. Bacteria colonizing on the mucous cell surface and proliferate extracellularly have developed a number of paralogs of surface proteins for antigenic variation, while bacteria which proliferate intracellularly have acquired genes for invasion and anti-active oxygen. The obligate intracellular parasites, Rickettsiae and Chlamydiae, have developed a distinct energy metabolism depending on the intracellular localization; Rickettsia prowazekii has TCA cycle and oxidative phosphorylation to proliferate in the cytoplasm, while Chlamydiae have a glycolytic pathway and substrate-level phosphorylation to multiply within an organella called inclusion bodies.
Nakazawa
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Department of Microbiology, Yamaguchi University School of Medicine.
D000940:Antigenic Variation; D001419:Bacteria / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000175:diagnosis / Q000628:therapy; D001428:Bacterial Vaccines; D004734:Energy Metabolism; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D006801:Humans; D016366:Open Reading Frames
D001428:Bacterial Vaccines