title: The effectiveness of topical treatment in discharging ears with in-dwelling ventilation tubes.
abstract: The efficacy and tolerability of topical treatment (both drops and spray) in the treatment of otorrhoea in those ears with ventilation tubes in-situ was studied. Sixty patients were randomised into two treatment groups. One group used an antibacterial/anti-inflammatory ear drop preparation (Otosporin) and the other group a similar preparation administered as an ear spray (Otomize). A 'blind' clinical assessment was made one and three weeks after commencing treatment. Both treatments (drops and spray) significantly improved patients' symptoms and signs after one week (p < 0.001). The spray was significantly easier to administer (p < 0.01) and caused less discomfort on application (p < 0.02).
authors.affiliation: York District Hospital, Bradford Royal Infirmary, ENT Department, United Kingdom.
authors.forename: D
authors.initials: D
authors.lastname: Strachan
authors.forename: S E
authors.initials: SE
authors.lastname: Clarke
authors.forename: R J
authors.initials: RJ
authors.lastname: England
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002558:Cerebrospinal Fluid Otorrhea / Q000175:diagnosis / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use*; D008876:Middle Ear Ventilation / Q000379:methods*; D009355:Neomycin / Q000627:therapeutic use*; D011112:Polymyxin B / Q000627:therapeutic use*; D011446:Prospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; C033225:hydrocortisone, neomycin, polymyxin B drug combination; D009355:Neomycin; D011112:Polymyxin B; D006854:Hydrocortisone