A review of the role of neurosecretion in the control of juvenile hormone synthesis: a tribute to Berta Scharrer.
In the 1950s, Berta Scharrer predicted that neurosecretions from the brain regulated corpus allatum activity based upon the observation of the change in localization of neurosecretory material in the brain and change in gland activity after severance of nerves between the brain and corpus allatum. Isolation and characterization of neuropeptide regulators of juvenile hormone production by the corpora allata in the late 1980s has confirmed this prediction. Both a stimulatory allatotropin and an inhibitory allatostatin have been isolated from moth brains. Two families of allatostatins, both quite different from each other and that of moths, have been isolated from cockroaches and crickets. The wide distribution of these peptides in the nervous system, in nerves to visceral muscle, in endocrine cells of the midgut and in blood cells, indicate multifunctions in the insects in which they are allatoregulatory. Some of these other functions have been demonstrated in these insects and in insects in which these neuropeptides occur but do not act as corpus allatum regulators. For the latter group, the neuropeptide regulators of the corpora allata have yet to be isolated. The families of neurosecretory regulators will continue to grow.
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Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA. barbara-stay@uiowa.edu
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000502:physiology*; D003335:Corpora Allata / Q000378:metabolism*; D049673:History, 20th Century; D006801:Humans; D007301:Insect Hormones / Q000266:history / Q000302:isolation & purification / Q000502:physiology*; D007605:Juvenile Hormones / Q000096:biosynthesis* / Q000266:history; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000266:history / Q000302:isolation & purification / Q000502:physiology*
D007301:Insect Hormones; D007605:Juvenile Hormones; D009479:Neuropeptides; C050669:allatotropin