title: Synthesis and in vitro antibacterial activity of 3-[N-methyl-N-(3-methyl-1,3-thiazolium-2-yl)aminolmethyl cephalosporin derivatives.
abstract: The new cephalosporins having N-linked quarternary ammonium salt at C-3 position were prepared from the reaction of 2-methylimino-3-methyl-1,3-thiazoline derivatives with cephalosporins. Also antimicrobial activities of those compounds were determined.
authors.affiliation: Biochemicals Research Center, Korea Institute of Science and Technology, Seoul, South Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Son
authors.forename: G
authors.initials: G
authors.lastname: Nam
authors.forename: D Y
authors.initials: DY
authors.lastname: Chi
authors.forename: J H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D013844:Thiazoles