title: The use of low-resolution FT-IR spectrometry for the analysis of alcohols in breath.
abstract: Fast and reliable diagnostic methods are needed for detection or exclusion of industrial solvents as a cause of intoxication. Analyzing human breath reveals the presence of any volatile substance. A portable Fourier transform infrared (FT-IR) multicomponent point-of-care analyzer was developed for exhaled breath. The analyzer proved to be accurate and precise in laboratory tests for simultaneous measurement of methanol and ethanol in water. Ethanol, in addition to normal contents of breath, was simultaneously analyzed in human experiments, and the results correlated well with blood samples. FT-IR method has a traceable calibration to physical properties of the analyte. The measured spectra can also be saved and analyzed later. Breath analysis with FT-IR is fast and easy, and no preparation of the sample is needed.
authors.affiliation: Department of Anesthesiology, Helsinki University Central Hospital, Finland. olli.laakso@helsinki.fi
authors.forename: O
authors.initials: O
authors.lastname: Laakso
authors.forename: M
authors.initials: M
authors.lastname: Haapala
authors.forename: P
authors.initials: P
authors.lastname: Jaakkola
authors.forename: R
authors.initials: R
authors.lastname: Laaksonen
authors.forename: J
authors.initials: J
authors.lastname: Nieminen
authors.forename: M
authors.initials: M
authors.lastname: Pettersson
authors.forename: M
authors.initials: M
authors.lastname: Räsänen
authors.forename: J J
authors.initials: JJ
authors.lastname: Himberg
mesh_terms: D000328:Adult; D000438:Alcohols / Q000032:analysis*; D001944:Breath Tests / Q000379:methods; D005554:Forensic Medicine / Q000379:methods; D006801:Humans; D008297:Male; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*
chemical_list: D000438:Alcohols