In vitro activity of eight fluoroquinolones against multiresistant Stenotrophomonas maltophilia.
We studied the activity of eight fluoroquinolones (norfloxacin, ciprofloxacin, grepafloxacin, trovafloxacin, gatifloxacin, clinafloxacin, PD-117596 and PD-138312) against 58 multiresistant Stenotrophomonas maltophilia clinical strains. Norfloxacin was the least active drug (MIC(90) = 128 mg/l). Grepafloxacin, trovafloxacin and gatifloxacin activity was moderately higher (MIC(90) = 8 mg/l) than ciprofloxacin (MIC(90) = 16 mg/l). The best activity was shown by clinafloxacin and PD-138312 (MIC(90) = 4 mg/l). The most resistant strains showed similar MICs against all the fluoroquinolones tested. The highest increase of activity of newer fluoroquinolones was observed against the most sensitive strains.
Sánchez-Hernández
J
J
Departamento de Microbiología, Hospital Universitario de Salamanca, Paseo de San Vicente s/n, 37007 Salamanca.
Manzanares
M A
MA
Gutiérrez Zufiaurre
M N
MN
Muñoz Criado
S
S
Muñoz Bellido
J L
JL
García-Rodríguez
J A
JA
D000890:Anti-Infective Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D024841:Fluoroquinolones; D006801:Humans; D020615:Stenotrophomonas maltophilia / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones