Anisocoria associated with the medical treatment of irritable bowel syndrome.
A case of anisocoria associated with oral pharmacologic treatment of irritable bowel syndrome is reported. A 26-year-old woman developed sudden onset of anisocoria and compromised accommodation that lasted 2 days after the use of oral scopolamine methylbromide for treatment of irritable bowel syndrome. The anisocoria and compromised accommodation occurred after contamination of the ocular surface after administration of scopolamine methylbromide and resolved within 1 week without further contamination. Oral preparations used for the pharmacologic treatment of irritable bowel syndrome can cause anisocoria due to anticholinergic pharmacologic blockade of the iris sphincter muscle.
Nussdorf
J D
JD
Department of Ophthalmology, Ochsner Clinic, New Orleans, Louisiana 70121, USA.
Berman
E L
EL
D000328:Adult; D015875:Anisocoria / Q000139:chemically induced*; D002924:Ciliary Body / Q000187:drug effects; D003109:Colonic Diseases, Functional / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007498:Iris / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D019832:N-Methylscopolamine / Q000009:adverse effects* / Q000627:therapeutic use; D010276:Parasympatholytics / Q000009:adverse effects* / Q000627:therapeutic use; D014792:Visual Acuity
D010276:Parasympatholytics; D019832:N-Methylscopolamine