[Prevalence of genetic prothrombotic factors (factor V Leiden and II20210 prothrombin mutation) in glomerular nephropathies with or without thrombosis].
The presence of genetic prothrombotic factors (factor V Leiden and the prothrombin II20210 mutation) was investigated in 38 patients with glomerulonephritis with or without a history of thrombotic events and/or nephrotic syndrome. We found an increased prevalence (36%) of heterozygous factor V Leiden in those patients with a history of thrombotic events. This is ten times the prevalence in the normal Spanish population. Carrier status for this mutation may be a determining factor in the development of thrombotic events along with the acquired disorders of coagulation to which these patients are prone. We found only one patient who was a carrier of the G-A II20210 mutation of the prothrombin gene; this patient had no history of venous thrombosis or embolism. Our findings suggest the need to measure activated protein C resistance and to look for the most frequent genotype causing it, Factor V Leiden, in patients with glomerulonephritis to identify those at risk who may benefit from prophylaxis against thrombosis.
Martínez Ara
J
J
Servicio de Nefrología, Hospital Universitario La Paz, Madrid.
Gómez Rioja
R
R
Riñón
C
C
García Muñoz
M S
MS
Ruiz Caravaca
M L
ML
Miguel
J L
JL
D020016:Activated Protein C Resistance / Q000235:genetics*; D000328:Adult; D000368:Aged; D005165:Factor V / Q000235:genetics*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015995:Prevalence; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis / Q000150:complications*
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin
Prevalencia de factores protrombóticos de base genética (factor V Leiden y mutación II20210 de la protrombina) en nefropatías glomerulares con o sin trombosis.