Carbamazepine-associated severe left ventricular dysfunction.
BACKGROUND
The cardiovascular effects of carbamazepine are well-known but left ventricular dysfunction is rarely reported.


METHODS
We describe 2 cases of severe carbamazepine-associated left ventricular dysfunction during massive self intoxications in young patients without preexistent cardiac disease. We compare our cases to the available literature and discuss the mechanisms implied in the development of left ventricular dysfunction following carbamazepine overdose. Bedside echocardiography was useful in both diagnosis and treatment.
Faisy
C
C
Service de Réanimation Médicale, Hôpital Boucicaut, Paris, France.
Guerot
E
E
Diehl
J L
JL
Rezgui
N
N
Labrousse
J
J
D000328:Adult; D018692:Antimanic Agents / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004280:Dobutamine / Q000627:therapeutic use; D062787:Drug Overdose; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D013406:Suicide, Attempted; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D016277:Ventricular Function, Left / Q000187:drug effects*
D018692:Antimanic Agents; D002316:Cardiotonic Agents; D002220:Carbamazepine; D004280:Dobutamine