Prevention of neoplastic port site implants in laparoscopy: an experimental study.
Enthusiasm about the application of videolaparoscopy to oncologic diseases has been limited by the growing number of port site implants. Adult Wistar rats were submitted to 6-7 mm Hg carbonic gas pneumoperitoneum. Rats were randomly divided into two groups: group I rats with tumor (200,000 viable cells of Walker tumor) and group 11 rats with no tumor. The pneumoperitoneum was deflated after 30 min. Group I was further randomized into five groups: no treatment; or abdominal irrigation with saline, heparin, chemotherapy (doxorubicin), or chemotherapy associated with heparin. After a period lasting no more than 18 days, the abdominal wall and intraperitoneal organs macroscopically affected were studied histologically. Chemotherapy groups had no port site implants and were significantly different (p < 0.05) than the no treatment, saline, and heparin solution groups, which had incisional implants at frequencies of 100%, 85.7%, and 82.5%, respectively. Intraperitoneal irrigation with chemotherapy solution was effective in preventing incisional implants in this animal model.
Schiavon
C A
CA
Pathophysiology Laboratory, University of São Paulo School of Medicine, Brazil.
Pollara
W M
WM
Bevilacqua
R G
RG
Younes
R N
RN
Vieira da Motta
T B
TB
Cohen
R V
RV
Itinoshe
M
M
Takasaka
L H
LH
Birolini
D
D
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002296:Carcinosarcoma / Q000401:mortality / Q000628:therapy*; D004195:Disease Models, Animal; D006493:Heparin / Q000008:administration & dosage*; D010535:Laparoscopy / Q000009:adverse effects*; D008297:Male; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000628:therapy*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D016019:Survival Analysis; D014741:Video Recording
D000970:Antineoplastic Agents; D006493:Heparin