title: Integrin-collagen complex: a metal-glutamate handshake.
abstract: The recently determined crystal structure of the complex between an integrin I domain and a synthetic collagen peptide shows a collagen triple-helix engaged in specific macromolecular recognition and binding. This structure confirms a previously proposed binding mechanism for integrin I domains and has important implications for integrin activation and signalling.
authors.affiliation: Wellcome Trust Centre for Cell-Matrix Research, School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK.
authors.forename: J
authors.initials: J
authors.lastname: Bella
authors.forename: H M
authors.initials: HM
authors.lastname: Berman
mesh_terms: D001665:Binding Sites; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D018698:Glutamic Acid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D016023:Integrins / Q000737:chemistry* / Q000378:metabolism; D046911:Macromolecular Substances; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011487:Protein Conformation; D015398:Signal Transduction
chemical_list: D016023:Integrins; D046911:Macromolecular Substances; D008670:Metals; D018698:Glutamic Acid; D003094:Collagen