Effects of prophylactic ibuprofen on cerebral and renal hemodynamics in very preterm neonates.
OBJECTIVE
To evaluate the effects on cerebral and renal blood flow velocities of ibuprofen when used as prophylaxis for patent ductus arteriosus in preterm neonates (gestational age <30 weeks).


METHODS
Blood flow velocities in the anterior cerebral artery and the renal artery were measured with Doppler ultrasonography in 17 neonates before, during, and 10, 30, and 60 minutes after administration of 10 mg/kg ibuprofen lysine.


RESULTS
In four (23.6%) neonates without echocardiographic patency of the ductus, no significant modifications in blood flow velocities and Doppler indexes were found either in the anterior cerebral artery or in the renal artery. In 13 (76.4%) neonates, cardiac echocardiographic Doppler showed patency of the ductus and left-to-right shunt. In these neonates diastolic and mean blood velocities rapidly increased both in the anterior cerebral artery and the renal artery (P < .0001). Resistance and pulsatility index decreased during the study period (P < .0001 and P < .001, respectively, in the anterior cerebral artery; P < .0001 in the renal artery).


CONCLUSIONS
Data suggest that ibuprofen does not determine any direct effect on cerebral and renal blood flow velocities; hemodynamic modifications observed in neonates with patency of ductus can be related to closure of the ductus induced by the drug.
Romagnoli
C
C
Department of Neonatology, Catholic University of Sacred Heart, Rome, Italy.
De Carolis
M P
MP
Papacci
P
P
Polimeni
V
V
Luciano
R
R
Piersigilli
F
F
Delogu
A B
AB
Tortorolo
G
G
D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004374:Ductus Arteriosus, Patent / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000517:prevention & control*; D015150:Echocardiography, Doppler; D005260:Female; D005865:Gestational Age; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology* / Q000627:therapeutic use; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011446:Prospective Studies; D012079:Renal Circulation / Q000187:drug effects*; D016896:Treatment Outcome
D007052:Ibuprofen