title: Granular acute lymphoblastic leukemia with hypereosinophilic syndrome.
abstract: A four-year-old boy presented with marked peripheral blood eosinophilia (absolute eosinophil count of 54 x 10(9)/1), features of hypereosinophilic syndrome, and acute lymphoblastic leukemia (ALL-L2), the latter characterized by the presence of granular blasts. Blasts were negative for myeloperoxidase, non-specific esterase, acid phosphatase, periodic-acid Schiff stain, and toluidine blue. They exhibited an early pre-B immunophenotype (TdT, CD19, CD10, CD20 and CD22 positive) and stained negative for T (CD7, CD2, CD5 and CD3) and myeloid markers (MPO, CD33 and CD13). Chromosomal analysis revealed a normal karyotype. To the best of our knowledge, this case represents the first report of the coexistence of granular ALL and hypereosinophilic syndrome.
authors.affiliation: Unit of Laboratory Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India. pareshjain@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Jain
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Gujral
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: Y
authors.initials: Y
authors.lastname: Jain
authors.forename: S
authors.initials: S
authors.lastname: Dubey
authors.forename: M
authors.initials: M
authors.lastname: Anand
authors.forename: L S
authors.initials: LS
authors.lastname: Arya
mesh_terms: D002675:Child, Preschool; D003594:Cytoplasmic Granules / Q000473:pathology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology*