Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract.
The role of lipid mediators derived from membrane glycerophospholipids and sphingolipids as intracellular messenger has been studied intensively during the last two decades, but with the recent discovery of high affinity G-protein coupled receptors for the lysophospholipids lysophosphatidic acid (LPA), sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC), increasing attention has been paid to the role of these lipid mediators as extracellular mediators. This review will summarize the biosynthesis and metabolism of lysophospholipids and describe the family of endothelial differentiation gene (EDG) receptors as high affinity receptors for lysophospholipids. Furthermore, an overview of the numerous biological effects of lysophospholipids which might be mediated by EDG receptors will be given together with an outlook on the potential role of such mechanisms in pulmonary physiology and pathophysiology.
Racké
K
K
Institute of Pharmacology & Toxicology, University of Bonn, Reuterstrabetae 2b, Bonn, D-53113, Germany. racke.kurt@uni-bonn.de
Hammermann
R
R
Juergens
U R
UR
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008246:Lysophospholipids / Q000378:metabolism* / Q000494:pharmacology; D009130:Muscle, Smooth / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; D015398:Signal Transduction; D013110:Sphingosine / Q000031:analogs & derivatives / Q000494:pharmacology
D008246:Lysophospholipids; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D049368:Receptors, Lysophosphatidic Acid; C060506:sphingosine 1-phosphate; D013110:Sphingosine