Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo.
Many bioflavonoids extracted from petals of higher plants and from fruit rinds, as well as purified flavonoids, have been reported to have antitumor effects in vitro and in vivo. Bioflavonoids extracted from red soybeans are mostly cyanin conjugated with glucose and rhamnose, whereas bioflavonoids of red beans are cyanin conjugated with rhamnose as revealed by thin-layer chromatogram. Flavonoids extracted from red soybeans were effective in inhibiting the growth of HCT-15 cells in vitro. On the other hand, flavonoids from red beans were not effective, although their hydrolyzed sugar-free forms were growth inhibitory. Sugar-bonded bioflavonoids extracted from both red soybeans and red beans were effective in prolonging the survival of Balb/C mice bearing syngeneic tumor-Meth/A cells, when they were dissolved in drinking water and given at a dose of approximately 500 micrograms/mouse/day.
Koide
T
T
Health Research Center, Aichi-Gakuin University, Japan.
Hashimoto
Y
Y
Kamei
H
H
Kojima
T
T
Hasegawa
M
M
Terabe
K
K
D000818:Animals; D000872:Anthocyanins / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D007887:Fabaceae; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D010946:Plants, Medicinal; D013025:Glycine max; D014407:Tumor Cells, Cultured
D000872:Anthocyanins; D000972:Antineoplastic Agents, Phytogenic