title: The effects of the concentration of high-density polyethylene particles on the bone-implant interface.
abstract: We used a rat model in vivo to study the effects of the concentration of polyethylene particles on the bone-implant interface around stable implants in the proximal tibia. Intra-articular injections of 10(4), 10(6) or 10(8) high-density polyethylene (HDPE) particles per joint were given 8, 10 and 12 weeks after surgery. The animals were killed after 14 and 26 weeks and the response at the interface determined. Fibrous tissue was seen at the bone-implant interface when the head of the implant was flush with the top of the tibia but not when it was sunk below the tibial plateau. In the latter case the implant was completely surrounded by a shell of bone. The area of fibrous tissue and that of the gap between the implant and bone was related to the concentration of particles in the 14-week group (p < 0.05). Foreign-body granulomas containing HDPE particles were seen at the bone-implant interface in animals given 10(8) particles. The pathology resembles that seen around prostheses with aseptic loosening and we suggest that this is a useful model by which to study this process.
authors.affiliation: Orthopaedic Research Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: R A
authors.initials: RA
authors.lastname: Brooks
authors.forename: J R
authors.initials: JR
authors.lastname: Sharpe
authors.forename: J A
authors.initials: JA
authors.lastname: Wimhurst
authors.forename: B J
authors.initials: BJ
authors.lastname: Myer
authors.forename: E N
authors.initials: EN
authors.lastname: Dawes
authors.forename: N
authors.initials: N
authors.lastname: Rushton
mesh_terms: D000818:Animals; D002516:Ceramics / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D015745:Granuloma, Foreign-Body / Q000201:enzymology / Q000209:etiology / Q000473:pathology; D006651:Histocytochemistry; D020007:Implants, Experimental / Q000009:adverse effects*; D008297:Male; D010316:Particle Size; D020959:Polyethylene / Q000008:administration & dosage / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D013997:Time Factors
chemical_list: D020959:Polyethylene