Downregulation of G protein-coupled receptors.
Major advances have been made in understanding mechanisms mediating downregulation of G protein-coupled receptors. Recent studies emphasize the role of multiple proteolytic mechanisms in downregulation. A specific mechanism of downregulation, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, has been examined in detail. Specific protein interactions that control the specificity of G-protein-coupled receptor trafficking in this pathway are beginning to be elucidated.
Tsao
P
P
Department of Psychiatry and Cellular and Molecular Pharmacology, Box 0984 IRE, Room LP-A104, University of California, San Francisco, San Francisco, CA 94143-0984, USA.
von Zastrow
M
M
D000818:Animals; D015536:Down-Regulation / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D009474:Neurons / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface; D019204:GTP-Binding Proteins