Heterogeneity in dementia: challenges and opportunities.
The major sources of heterogeneity in the manifestation of dementia are analyzed as stemming from three types of sources: initial predisposing factors, lifelong events, and the current condition. Each of these sources is, in turn, comprised of three general domains: genetic/biologic/medical, psychosocial, and environmental. These influences affect the manifestation of dementia in terms of cognitive, behavioral, self-maintenance, and affective functioning. Mapping the sources and manifestations of this heterogeneity can lead to both a more thorough understanding of people with dementia and the development of management settings and interventions that are more responsive to people with dementia.
Cohen-Mansfield
J
J
Research Institute of the Hebrew Home of Greater Washington, Rockville, Maryland 20852, USA.
D000203:Activities of Daily Living; D000339:Affect; D000368:Aged; D003071:Cognition; D003704:Dementia / Q000145:classification* / Q000523:psychology / Q000534:rehabilitation; D005192:Family Health; D006304:Health Status; D006801:Humans; D011788:Quality of Life; D012944:Social Support