title: Efficacy of minocycline as a root conditioner in comparison to citric acid and tetracycline. An in vitro evaluation.
abstract: This study compared the root surface characteristics produced by Minocycline HCl, Citric acid and Tetracycline HCl. when used as a root conditioner. This study included 5 groups of 10 extracted teeth each with advanced periodontal disease. Diseased root surfaces of group B,C,D and E were planed with Gracy curets and solutions of Citric acid, Tetracycline HCl, Monocycline Hcl and Tween 80 of PH 2.5, were applied to the surface in respective groups with cotton pellets for 5 mts. Group A was not subjected to root planning or application of any root conditioner and was used as a control. The teeth in all five groups were then washed, sectioned processed and examined under scanning electron microscope. These results revealed that the surfaces of acid treated sites differed from each other and with specimens treated sites differed from each other and with specimens treated with root panning alone. The efficacy of Minocycline and tetracycline in the removal of smear layer and exposure of dentinal tubules were comparable and Minocycline HCl though not as effective as Citric acid can probably be recommended in view of its antibactrial activity, anti collagense and substantivity properties.
authors.affiliation: Department of Periodontics, College of Dental Surgery, Manipal, India.
authors.forename: B S
authors.initials: BS
authors.lastname: Thomas
authors.forename: B R
authors.initials: BR
authors.lastname: Varma
authors.forename: K M
authors.initials: KM
authors.lastname: Bhat
mesh_terms: D000134:Acid Etching, Dental; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002265:Carboxylic Ester Hydrolases / Q000494:pharmacology / Q000627:therapeutic use; D019343:Citric Acid / Q000494:pharmacology / Q000627:therapeutic use; D003804:Dentin / Q000187:drug effects; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008911:Minocycline / Q000494:pharmacology / Q000627:therapeutic use*; D010510:Periodontal Diseases / Q000188:drug therapy*; D016369:Smear Layer; D013752:Tetracycline / Q000494:pharmacology / Q000627:therapeutic use; D014092:Tooth Root / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D019343:Citric Acid; D002265:Carboxylic Ester Hydrolases; C044495:tween 80 esterase; D013752:Tetracycline; D008911:Minocycline