title: The Gorham-Stout syndrome (Gorham's massive osteolysis). A report of six cases with histopathological findings.
abstract: The Gorham-Stout Syndrome (Gorham's massive osteolysis) is a rare condition in which spontaneous, progressive resorption of bone occurs. The aetiology is poorly understood. We report six cases of the condition and present evidence that osteolysis is due to an increased number of stimulated osteoclasts. This suggests that early potent antiresorptive therapy such as with calcitonin or bisphosphonates may prevent local progressive osteolysis.
authors.affiliation: Department of Bone Pathology, Hamburg University School of Medicine, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Möller
authors.forename: M
authors.initials: M
authors.lastname: Priemel
authors.forename: M
authors.initials: M
authors.lastname: Amling
authors.forename: M
authors.initials: M
authors.lastname: Werner
authors.forename: A S
authors.initials: AS
authors.lastname: Kuhlmey
authors.forename: G
authors.initials: G
authors.lastname: Delling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D010010:Osteoclasts / Q000187:drug effects / Q000473:pathology; D010015:Osteolysis, Essential / Q000188:drug therapy / Q000473:pathology*; D013577:Syndrome
chemical_list: D004164:Diphosphonates; D002116:Calcitonin