title: Population benefits of cholesterol reduction: epidemiology, economics, and ethics.
abstract: Cardiovascular disease mortality-rate reductions have slowed in the United States in the last decade, suggesting that additional strategies are needed to reduce rates further. Population-wide cholesterol reduction is a promising approach. Selection of a particular strategy is less an issue of efficacy, which has been proven through numerous studies, than it is an issue of epidemiology, economics, and ethics. These 3 imperatives constitute the foundation of renewed efforts to reduce the US population's cholesterol levels. Epidemiologic imperatives include risk reduction in low-to-moderate risk individuals, who comprise approximately 30% of the population and one third of incident cases of coronary disease. Any cholesterol-lowering strategy must address the challenge of reducing the incidence of coronary disease; to do otherwise will result in an increasing prevalence of disease, with the attendant cost and disability burdens. Economic imperatives include the extension of preventive coverage to the low-to-moderate risk segment of the population, which currently is not included in any risk-reduction programs. Although cholesterol reduction with pharmacologic agents may not meet current standards for cost-effectiveness, over-the-counter (OTC) agents are under the rubric of individual, not societal, costs. Finally, current and proposed options for nonprescription cholesterol-lowering drugs raise a number of ethical issues such as beneficence, nonmaleficence, justice, and autonomy. Population-wide cholesterol reduction must be a mainstay for any strategy to reduce the burden of cardiovascular disease.
authors.affiliation: Department of Community and Preventive Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Pearson
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000191:economics / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D004992:Ethics, Medical; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000191:economics / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D009749:Nutrition Surveys; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D000960:Hypolipidemic Agents