Elevated phosphorylation of AKT and Stat3 in prostate, breast, and cervical cancer cells.
We examined whether the persistent activation of AKT or Stat3 oncogene product is present in prostate, breast, and cervical cancer cells. We found that some prostate and breast cancer cell lines express high levels of phosphorylated AKT. Interestingly, the cancer cells, which only express low levels of phosphorylated AKT express high levels of phosphorylated Stat3. AKT or Stat3 is also highly phosphorylated in human papilloma virus-negative cervical cancer cells. Therefore, these results indicate that AKT and Stat3 are highly phosphorylated in some breast, prostate and cervical cancer cells, which may play a role in tumorigenesis of these cancers.
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Department of Obstetrics and Gynecology, The University of Michigan Comprehensive Cancer Center, Ann Arbor 48109, USA.
Huang
M
M
Jin
X
X
Cho
K
K
Lilja
J
J
Reynolds
R K
RK
Lin
J
J
D001943:Breast Neoplasms / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051058:Oncogene Protein v-akt; D010766:Phosphorylation; D011471:Prostatic Neoplasms / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D015682:Retroviridae Proteins, Oncogenic / Q000032:analysis / Q000378:metabolism*; D050796:STAT3 Transcription Factor; D015534:Trans-Activators / Q000032:analysis / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000378:metabolism*
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D015534:Trans-Activators; D011505:Protein-Tyrosine Kinases; C494918:AKT1 protein, human; D051058:Oncogene Protein v-akt; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt