title: Protein structure computing in the genomic era.
abstract: Functional analysis of the proteins discovered in fully sequenced genomes represents the next major challenge of life science research. Computational methods play a crucial role in this activity and, among them, comparative protein modelling is of great assistance during the rational design of mutagenesis experiments. Our aim over the last several years has been to further the use of 3-D model structures in this field. Therefore, we have developed a comparative protein modelling environment composed of the Swiss-PdbViewer (sequence to structure workbench and viewing program), SWISS-MODEL (internet-based server for model generation) and a database of a model generated with 3DCrunch.
authors.affiliation: Glaxo Wellcome Experimental Research, Swiss Institute for Bioinformatics, Plan-Les-Ouates.
authors.forename: T
authors.initials: T
authors.lastname: Schwede
authors.forename: A
authors.initials: A
authors.lastname: Diemand
authors.forename: N
authors.initials: N
authors.lastname: Guex
authors.forename: M C
authors.initials: MC
authors.lastname: Peitsch
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D016208:Databases, Factual; D016678:Genome; D023281:Genomics; D020407:Internet; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012984:Software
chemical_list: D011506:Proteins