title: [Plasmocytic pleural effusion disclosing multiple myeloma].
abstract: Pleural effusion caused by plasma cell involvement in multiple myeloma has been reported unfrequently, and has been described at a frequency below 1% of multiple myeloma. In this study, we report an observation with pleural effusion as first symptom of multiple myeloma. The analysis of the pleural liquid showed plasma cells with a monoclonal IgG Kappa immunoglobulin. In addition, there was a bone marrow infiltration by plasma cells, a serum monoclonal immuno-globulin of the same type and osteolytic lesions. Our patient has received one course of chemotherapy with: vincristine, melphalan, cyclophosphamide and prednisone. The patient did not respond to the therapy and died one month later. Pleural effusion seems to be an expression of aggressive myeloma. Survival exceeds rarely 4 months.
authors.affiliation: Service d'Onco-Hématologie, CHU Hédi Chaker, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Elloumi
authors.forename: M
authors.initials: M
authors.lastname: Frikha
authors.forename: H
authors.initials: H
authors.lastname: Masmoudi
authors.forename: S
authors.initials: S
authors.lastname: Mseddi
authors.forename: M
authors.initials: M
authors.lastname: Ben Ayed
authors.forename: M
authors.initials: M
authors.lastname: Bouaziz
authors.forename: F
authors.initials: F
authors.lastname: Makni
authors.forename: T
authors.initials: T
authors.lastname: Souissi
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis / Q000097:blood; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000097:blood; D008558:Melphalan / Q000008:administration & dosage; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D010014:Osteolysis / Q000276:immunology / Q000473:pathology; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*; D010996:Pleural Effusion / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000911:Antibodies, Monoclonal; D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D000972:Antineoplastic Agents, Phytogenic; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D014750:Vincristine; D003520:Cyclophosphamide; D008558:Melphalan; D011241:Prednisone
vernacular_title: Epanchement pleural plasmocytaire révélateur d'un myélome multiple.