SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.
Inhibition studies of 4-hydroxyphenylpyruvate dioxygenase (HPPD) with various synthesized 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones suggest that the presence of a strongly electronegative group at the ortho position and the conformation of the benzene ring moiety on the benzoylcyclohexane-1,3-dione inhibitors are crucial for potent HPPD inhibition.
Lin
Y L
YL
Department of Chemistry, Tunghai Christian University, Taichung, Taiwan, ROC.
Wu
C S
CS
Lin
S W
SW
Yang
D Y
DY
D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002384:Catalysis; D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D013329:Structure-Activity Relationship; D013552:Swine
D000473:Alkanes; D003510:Cyclohexanes; D004791:Enzyme Inhibitors; D007659:Ketones; D015111:4-Hydroxyphenylpyruvate Dioxygenase