title: [Changes in the asynchronism of transmitter release in a neuromuscular synapse and the time course of evoke postsynaptic signals during growth and branching og frog nerve ending].
abstract: The influence of both growth and branching of a nerve terminal on the asynchronism of transmitter release and the time-course of evoked postsynaptic responses was investigated using a model of a frog neuromuscular synapse in which the nerve terminal represents a population of spatially isolated active zones. It was shown that the appearance of additional branching in proximal parts of the nerve ending leads to decrease in the asynchronism of transmitter release, an increase in quantum content and the amplitude of the postsynaptic signal, and the shortening of its phase of growth. It was found that the asynchronism of transmitter release has a much stronger influence on the time-course of end plate currents compared with end plate potentials. The factors strengthening and weakening the asynchronism of transmitter release in a neuromuscular synapse and the reasons for various length and branching of vertebrate nerve terminals are considered.
authors.affiliation: Kazan State Medical University, Russia.
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
authors.forename: O Sh
authors.initials: OSh
authors.lastname: Gafurov
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005071:Evoked Potentials; D008954:Models, Biological; D009411:Nerve Endings / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology*; D011898:Ranidae; D009435:Synaptic Transmission / Q000502:physiology*
vernacular_title: Izmeneniia asinkhronnosti osvobozhdeniia mediatora i amplitudno-vreme nnykh parametrov vyzvannykh postsinapticheskikh signalov v protsesse rosta i vetvleniia nervnogo okonchaniia liagushki.