title: Dietary content may prevent secondary hyperparathyroidism in female rhesus monkeys (Macaca mulatta).
abstract: Macaque laboratory chows provide relatively more calcium (Ca) and vitamin D (D) than human diets; this may influence skeletal aging. To evaluate this possibility, parameters of skeletal relevance in premenopausal and naturally postmenopausal rhesus monkeys were measured in a cross-sectional study. Serum osteocalcin (Oc) was elevated in the postmenopausal group (P < 0.01), but levels of parathyroid hormone (PTH) and 25-hydroxyvitamin D (25OHD) were not different. Subsequently, in premenopausal animals, dietary Ca and/or D intake was reduced to optimal human levels for 8 weeks prior to the evaluation of the skeletal parameters. Serum 25OHD concentration was reduced (P < 0.01) and a trend (P=0.10) towards increased PTH was observed in both low D groups. In addition, serum alkaline phosphatase (ALP) levels were increased in the low Ca group (P < 0.01). In conclusion, skeletal turnover, as measured by serum Oc, was increased in naturally postmenopausal rhesus monkeys in the absence of hyperparathyroidism. Dietary D reduction causes a decline in serum 25OHD and an upward trend in PTH.
authors.affiliation: Wisconsin Regional Primate Research Center, Department of Medicine, University of Wisconsin, Madison, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Bruner
authors.forename: B I
authors.initials: BI
authors.lastname: Davidowitz
authors.forename: A M
authors.initials: AM
authors.lastname: Haffa
authors.forename: N
authors.initials: N
authors.lastname: Binkley
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D002136:Calcium, Dietary / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000503:physiopathology*; D008253:Macaca mulatta; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D017698:Postmenopause / Q000502:physiology
chemical_list: D002136:Calcium, Dietary; D000469:Alkaline Phosphatase