Modification of radiosensitivity of chlorpromazine with biological metal ions in Thiobacillus ferrooxidans.
Effect of chlorpromazine with biological metal ions, viz. calcium, magnesium, zink and copper was studied on T. ferrooxidans cell system. Chlorpromazine, calcium and magnesium alone could produce radioprotection. Maximum radioprotection was exhibited by chlorpromazine at lower concentration while copper and zink offered radiosensitization. However, combination of chlorpromazine with all biological metal ions exhibited radiosensitization. Dose modifying factor by chlorpromazine at lower concentration (0.025 mM) was 0.754 while in combination with Ca2+, Mg2+, Cu2+ and Zn2+ was 1.08, 1.25, 1.37 and 1.389 respectively. The possible interaction between chlorpromazine and biological metal ions is discussed at cellular membrane level.
Dongre
P M
PM
Department of Biophysics, Institute of Science, Aurangabad, India.
Khole
V
V
Kadu
B B
BB
D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects; D002746:Chlorpromazine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D008670:Metals / Q000008:administration & dosage; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage; D013855:Thiobacillus / Q000187:drug effects* / Q000528:radiation effects*
D008670:Metals; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; D002746:Chlorpromazine