Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
Preliminary SAR studies on the side chain of a new class of antiviral nucleosides have shown that terminal substitution in the side-chain, with a halogen atom, lead to potent and highly specific anti-VZV agents.
Brancale
A
A
Welsh School of Pharmacy, Cardiff University, UK.
McGuigan
C
C
Andrei
G
G
Snoeck
R
R
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D006219:Halogens / Q000737:chemistry*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D006219:Halogens; D009705:Nucleosides