title: [Diagnostic value of some cytokines levels in chronic myelogenous leukemia].
abstract: Some cytokines play an important role in aetiology and pathogenesis of leukaemia. Majority of data available in the literature relates to a single cytokine in the cell culture in vitro. In patients with chronic myelogenous leukaemia several different cytokines are probably active. Therefore, this study aimed to determine the concentrations of interleukin-1 beta, G-CSF, L-selectin in leukaemia cell culture supernatant, broken granulocytes and plasma in the course of disease exacerbation and remission. Cytokines have been assayed with available immunoenzymatic kits of ELISA type. IL-1 beta, G-CSF and L-selectin levels have been increased in cell supernatant but IL-1 beta level has been decreased in non-stimulated broken granulocytes. G-CSF levels have been low both in stimulated and non-stimulated granulocytes. In comparison to control the lowered levels of G-CSF and L-selectin have been observed in blood plasma of patients with CML. Different levels of assayed cytokines and adhesion molecule may suggest their contribution to leukaemia cells proliferation regulation.
authors.affiliation: Kliniki Hematologii Akademii Medycznej w Białymstoku.
authors.forename: B
authors.initials: B
authors.lastname: Kiersnowska-Rogowska
authors.forename: A
authors.initials: A
authors.lastname: Parfieńczyk
authors.forename: F
authors.initials: F
authors.lastname: Rogowski
authors.forename: A
authors.initials: A
authors.lastname: Citko
authors.forename: E
authors.initials: E
authors.lastname: Jaroszewicz
mesh_terms: D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis* / Q000276:immunology*; D012074:Remission Induction
chemical_list: D016207:Cytokines
vernacular_title: Wartość diagnostyczna aktywności stezeń cytokin w przewlekłej białaczce szpikowej.