Post-operative consequences of glove powder used pre-operatively in the vagina in the rabbit model.
This study was undertaken to determine if a retrograde migration of glove powder (Biosorb(TM)) from the vagina into the abdominal cavity in combination with a subsequent intra-abdominal trauma could affect the development of adhesions. A rabbit model was used with one control and one test group. A total of 50 mg Biosorb(TM) was deposited intravaginally in the test cases before ovulation was induced. Three days later a laparotomy with a small standardized surgical trauma was carried out on the left Fallopian tube and the ipsilateral peritoneum. Ten days later the extent of intra-abdominal adhesions was evaluated. The presence of starch particles in cell smears and biopsies was also investigated. Significant differences in the formation of adhesions were found between the control and the test cases (P < 0.001). In the test group there were dense adhesions and in four cases the Fallopian tube was completely attached to the peritoneal wall. In the control cases only loose minor adhesions were found. This study indicates that the number of starch particles migrating from the vagina to the abdominal cavity is sufficient to enhance significantly the formation of post-operative adhesions. We therefore suggest that powder-free medical or surgical gloves should be used in obstetrics and gynaecology.
Sjösten
A C
AC
Karolinska Institute, Department of Obstetrics and Gynaecology at Stockholm Söder Hospital, S-118 83 Stockholm, Sweden. Anette.Sjosten@sos.ki.se
Ellis
H
H
Edelstam
G A
GA
D000005:Abdomen; D000818:Animals; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D005932:Gloves, Surgical; D010537:Peritoneum / Q000601:surgery; D011183:Postoperative Complications / Q000139:chemically induced*; D011208:Powders / Q000009:adverse effects* / Q000493:pharmacokinetics; D011817:Rabbits; D013213:Starch / Q000009:adverse effects* / Q000493:pharmacokinetics; D000267:Tissue Adhesions / Q000139:chemically induced* / Q000473:pathology; D014621:Vagina / Q000378:metabolism
D011208:Powders; D013213:Starch