title: Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats.
abstract: Striatal glutamate release during novelty exposure-induced hyperactivity was studied by microdialysis in freely-moving olfactory bulbectomized (OBX) rats. After collecting three 10 min basal striatal dialysate samples, the animals were transferred to an open-field apparatus (novelty) and locomotor activity recorded for 60 min. OBX rats showed significantly more locomotor activity (1210+/-270 cm) than sham-operated rats (420+/-70 cm), but only in the first 10 min after exposure to the novel environment. During the same period, striatal glutamate levels increased to 163+/-21% of the basal value in OBX rats, while no changes were seen in the striatum of sham-operated controls. These findings suggest that olfactory bulbectomy results in an increased response of the striatal glutamatergic system to novelty stress, and may consequently cause hyperactivity.
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, Republic of China.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Ho
authors.forename: Y C
authors.initials: YC
authors.lastname: Chang
authors.forename: T M
authors.initials: TM
authors.lastname: Liu
authors.forename: M Y
authors.initials: MY
authors.lastname: Tai
authors.forename: C S
authors.initials: CS
authors.lastname: Wong
authors.forename: Y F
authors.initials: YF
authors.lastname: Tsai
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism*; D003714:Denervation; D005106:Exploratory Behavior / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D008124:Locomotion / Q000502:physiology; D008297:Male; D017551:Microdialysis; D009830:Olfactory Bulb / Q000601:surgery*; D011595:Psychomotor Agitation / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D018698:Glutamic Acid