[An investigation of serum soluble interferon receptor levels in patients with renal cell carcinoma].
OBJECTIVE
Serum soluble interferon alpha/beta receptor (s-IFN-receptor) levels were determined in renal cell carcinoma (RCC) patients to study the clinical significance of the measurement.


METHODS
S-IFN-receptor levels were measured in RCC patients (n = 27) and healthy volunteers (n = 22) by enzyme immunoassay technique.


RESULTS
Significantly higher serum s-IFN-receptor levels were observed in RCC patients compared with the healthy volunteers (p < 0.003). The high s-IFN receptor levels in the patients suggested seriousness and mal-prognosis of this disease. The 4-years survival rate of the higher level group (with the mean value of 2.7 +/- 1.7 ng/ml or more) was 53.3%, while the lower level group's rate was 78.7% (Statistical analysis result by Logrank (Mantel-Cox) test; p = 0.4289).


CONCLUSIONS
Further study in more subjects is required to determine the feasibility of the s-IFN receptor levels as a prognosis marker, since correlation between the prognosis and s-IFN receptor level was not clarified by this study result.
Iseda
T
T
Department of Urology, Ehime Medical University.
Yokoyama
M
M
Kanayana
H
H
Oomoto
Y
Y
Kagawa
S
S
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000097:blood*; D015996:Survival Rate
D015415:Biomarkers; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta