Action of ozonized water in preclinical inflammatory models.
Ozonized water increases oxygen local tension. The ozone by itself produces inflammatory reactions in lung epithelium. The action of ozonized water during the inflammatory process was investigated. In rat paw edema induced by carrageenin, the inflammatory process was stimulated by ozonized water (1.2 microg, p.o.) when applied 30 min prior to the induction. In the inflammatory process induced by Freund's Complete Adjuvant, the ozonized water did not interfere in the inflammatory reaction. Furthermore, in gastric ulcers models induced by stress, there was a significant reduction in the incidence of ulcers types I, II and III (P<0.05, Student's t -test).
Cardoso
C C
CC
Laboratorio de Fitofarmacos, Instituto de Farmacia e Nutricao, Universidade de Alfenas, MG, Brasil.
Carvalho
J C
JC
Ovando
E C
EC
Macedo
S B
SB
Dall'Aglio
R
R
Ferreira
L R
LR
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D010126:Ozone / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000188:drug therapy*; D014867:Water
D000893:Anti-Inflammatory Agents; D014867:Water; D010126:Ozone