The inhibitory effect of the imidazoquinolinamine S-28828 on the pathogenesis of a type II adenovirus in turkeys.
In this study we show that a type I-IFN inducing compound, S-28828, modulated the pathogenesis of an avian type II adenovirus in turkeys. By itself, S-28828 induced a strong reaction in the spleen characterized by hyperplasia of the red and white pulps as well as an increase in lymphoid cell aggregations. Oral administration of S-28828 before the time of virus inoculation suppressed significantly (P<0.05) the replication of hemorrhagic enteritis virus (HEV) in turkeys. Two doses of 5 or 50 mg of S-28828 administered at 2 days before and at the day of virus inoculation inhibited HEV-induced pathological and histopathological lesions. Virus-induced apoptosis and reduced IgM-surface expression of B cells were suppressed by low dose S-28828 treatment. These results are of interest because mammalian adenoviruses were shown to be resistant to antiviral effects of type I IFN, the major effector cytokine induced by S-28828.
Rautenschlein
S
S
Department of Veterinary PathoBiology, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
Miller
R L
RL
Sharma
J M
JM
D000257:Adenoviridae Infections / Q000188:drug therapy / Q000662:veterinary* / Q000821:virology; D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D000259:Aviadenovirus / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D004751:Enteritis / Q000188:drug therapy / Q000662:veterinary / Q000821:virology; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000662:veterinary / Q000821:virology; D007369:Interferon Inducers / Q000627:therapeutic use*; D011201:Poultry Diseases / Q000188:drug therapy* / Q000821:virology; D014422:Turkeys; D014774:Virulence; D014779:Virus Replication / Q000187:drug effects
D000634:Aminoquinolines; D007369:Interferon Inducers; C105792:S 28828