Cancer genetics for the clinician: recommendations on screening for BRCA1 and BRCA2 mutations.
Mutations in the BRCA1 and BRCA2 genes confer a greatly increased risk of breast cancer, ovarian cancer, and other malignant diseases. This paper offers recommendations about who should be screened for BRCA mutations, and insights into the ramifications of BRCA testing.
Clark
B A
BA
Taussig Cancer Center, Cleveland Clinic, USA. clarkb@cc.ccf.org
D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control; D005260:Female; D019398:Genes, BRCA1 / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics*; D005817:Genetic Counseling; D006801:Humans; D008403:Mass Screening; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000517:prevention & control