Chimeric del20q in a case of chronic neutrophilic leukemia.
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder in which recurrent abnormalities of chromosome 20 have been reported. We report the case of a 76-year-old woman with CNL with partial deletion of the long arm of chromosome 20 in a subset of bone marrow metaphases, suggesting coexistence of a clonal stem cell disorder and normal hematopoiesis. Review of the literature suggests that such mosaicism is common in CNL, possibly accounting for the favorable prognosis observed in many patients with this disorder.
Frank
M B
MB
Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA.
Norwood
T H
TH
Willerford
D M
DM
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002678:Chimera; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D005260:Female; D006801:Humans; D007621:Karyotyping; D015467:Leukemia, Neutrophilic, Chronic / Q000235:genetics*; D007962:Leukocytes / Q000201:enzymology; D009030:Mosaicism
D000469:Alkaline Phosphatase