title: The complete nucleotide sequence of fowl adenovirus type 8.
abstract: The fowl adenovirus type 8 (FAdV-8) genome was sequenced and found to be 45063 nucleotides in length, the longest adenovirus (AdV) genome for which the complete nucleotide sequence has been determined so far. No regions homologous to early regions 1, 3 and 4 (E1, E3 and E4) of mastadenoviruses were recognized. Gene homologues for early region 2 (E2) proteins, intermediate protein IVa2 and late proteins were found by their similarities to protein sequences from other AdVs. However, sequences homologous to intermediate protein IX and late protein V could not be identified. Sequences for virus-associated RNA could also not be recognized. Two regions of repeated sequences were found on the FAdV-8 genome. The shorter repeat region contained five identical and contiguous direct repeats that were each 33 bp long, while the longer repeat region was made of 13 identical and contiguous, 135 bp long repeated subunits.
authors.affiliation: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, N1G 2W1 Ontario, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Ojkic
authors.forename: E
authors.initials: E
authors.lastname: Nagy
mesh_terms: D000259:Aviadenovirus / Q000235:genetics*; D001483:Base Sequence; D004279:DNA, Viral / Q000737:chemistry*; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D012091:Repetitive Sequences, Nucleic Acid
chemical_list: D004279:DNA, Viral