Connecting vesicle transport to the cytoskeleton.
The cytoskeleton is crucial for the efficient and polarized transport of vesicles in intracellular membrane-sorting pathways. Recent studies have identified specific kinesin, dynein, and myosin motor proteins that mediate defined membrane transport steps. Important clues have also been uncovered about the nature of motor-protein receptors on vesicular cargoes and the molecular mechanisms of motor-protein regulation.
Kamal
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A
Department of Cellular and Molecular Medicine, Department of Pharmacology, Howard Hughes Medical Institute, School of Medicine, University of California San Diego, La Jolla, 92093-0683, USA.
Goldstein
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LS
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*
D002352:Carrier Proteins; D008869:Microtubule-Associated Proteins