title: Evidence-based medicine and health economics: a case study of end stage renal disease.
abstract: This paper explores the potential for use of an economic evaluation framework alongside systematic reviews. Clinical issues in dialysis therapy for end stage renal disease are used as case studies. The effectiveness data required were obtained from a systematic review of randomized controlled trials. Resource use and cost data were obtained from three sources; the identified randomized controlled trials, a separate review of observational studies and primary data collection. The results of the case studies show that, although simple economic evaluations were possible, issues arose, such as how transferable results are between settings and how appropriate it is to focus on the average patient. The interface between economic evaluation and systematic reviews needs to be further developed in order to ensure that the best available evidence can be used to inform future policy and research.
authors.affiliation: Health Economics Research Unit, University of Aberdeen, UK.
authors.forename: L
authors.initials: L
authors.lastname: Vale
authors.forename: C
authors.initials: C
authors.lastname: Donaldson
authors.forename: C
authors.initials: C
authors.lastname: Daly
authors.forename: M
authors.initials: M
authors.lastname: Campbell
authors.forename: J
authors.initials: J
authors.lastname: Cody
authors.forename: A
authors.initials: A
authors.lastname: Grant
authors.forename: I
authors.initials: I
authors.lastname: Khan
authors.forename: P
authors.initials: P
authors.lastname: Lawrence
authors.forename: S
authors.initials: S
authors.lastname: Wallace
authors.forename: A
authors.initials: A
authors.lastname: MacLeod
mesh_terms: D016009:Chi-Square Distribution; D003362:Cost-Benefit Analysis; D019317:Evidence-Based Medicine; D006302:Health Services Research; D006801:Humans; D007676:Kidney Failure, Chronic / Q000191:economics* / Q000628:therapy; D017063:Outcome Assessment, Health Care; D016032:Randomized Controlled Trials as Topic / Q000191:economics*; D006435:Renal Dialysis / Q000379:methods; D012107:Research Design