title: Inspiratory pressure support prolongs exercise induced lactataemia in severe COPD.
abstract: BACKGROUND
  A physiological benefit from pulmonary rehabilitation in chronic obstructive pulmonary disease (COPD) is more probable if exercise is performed above the lactate threshold. This study was undertaken to investigate whether it was possible to extend the lactataemia of exercise using non-invasive inspiratory pressure support (IPS).
  
  
  METHODS
  Plasma lactate levels were measured in eight men with severe COPD who performed two treadmill walks at an identical constant work rate to a condition of severe dyspnoea; the second walk was supported by IPS.
  
  
  RESULTS
  Mean plasma lactate levels before the free and IPS assisted walks were 1.65 mmol/l and 1. 53 mmol/l, respectively (p = NS). Lactate levels increased during both walks to 2.96 mmol/l and 2.42 mmol/l, respectively (p = 0.01 for each) but the duration of the IPS assisted walk was significantly greater than the free walk (13.6 minutes versus 5.5 minutes, p = 0.01).
  
  
  CONCLUSIONS
  Patients with severe COPD can sustain exercise induced lactataemia for longer if assisted with IPS. This technique may prove to be a useful adjunct in pulmonary rehabilitation.
authors.affiliation: Respiratory Muscle Laboratory, Royal Brompton Hospital, London SW3 6HP, UK. m.polkey@rbh.nthames.nhs.uk
authors.forename: M I
authors.initials: MI
authors.lastname: Polkey
authors.forename: P
authors.initials: P
authors.lastname: Hawkins
authors.forename: D
authors.initials: D
authors.lastname: Kyroussis
authors.forename: S G
authors.initials: SG
authors.lastname: Ellum
authors.forename: R
authors.initials: R
authors.lastname: Sherwood
authors.forename: J
authors.initials: J
authors.lastname: Moxham
mesh_terms: D000142:Acidosis, Respiratory / Q000209:etiology / Q000628:therapy; D000368:Aged; D004417:Dyspnea / Q000209:etiology / Q000503:physiopathology; D005081:Exercise Therapy / Q000379:methods*; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007384:Intermittent Positive-Pressure Breathing / Q000379:methods*; D019344:Lactic Acid / Q000097:blood*; D008173:Lung Diseases, Obstructive / Q000097:blood* / Q000503:physiopathology / Q000534:rehabilitation; D008297:Male
chemical_list: D019344:Lactic Acid