Mechanisms of neurotoxic injury and cell death.
Neurotoxic injury to the nervous system produces neuronal death or distal axonal degeneration. Neurotoxin-induced demyelination is relatively rare in the peripheral and central nervous systems. Major advances have occurred in our understanding of the mechanisms of apoptotic cell death. The pathways leading to apoptosis offer many new approaches to neuroprotection.
McDonald
E S
ES
Graduate Student, Molecular Neuroscience Program, Mayo Graduate School, Rochester, MN 55905, USA.
Windebank
A J
AJ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D003711:Demyelinating Diseases / Q000139:chemically induced; D006801:Humans; D009410:Nerve Degeneration / Q000139:chemically induced; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D020258:Neurotoxicity Syndromes / Q000145:classification / Q000209:etiology*; D009498:Neurotoxins / Q000009:adverse effects* / Q000145:classification
D009498:Neurotoxins