Effects of 9 Kampo medicines clinically used in hypertension on hemodynamic changes induced by theophylline in rats.
We examined the effects of 9 kinds of Kampo medicines, which are clinically used for the treatment of hypertension, on anesthetized rats with increases in arterial blood pressure, heart rate and peripheral blood flow induced by theophylline (5 mg/kg, i.v.) that were partially or completely mediated by endogenous catecholamines. Each Kampo medicine (1 g/kg) was intraduodenaly administered. Shinbu-to caused a severe disturbance of the arterial blood pressure. Saiko-ka-ryukotsu-borei-to, Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to had hypotensive effects, while Hachimi-jio-gan, Gosha-jinki-gan, Dai-saiko-to and Choto-san did not have such an effect. Moreover, Saiko-ka-ryukotsu-borei-to attenuated the heart rate. In Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to, a reduction in peripheral blood flow was observed. These results suggest that Saiko-ka-ryukotsuborei-to, Oren-gedoku-to, San'o-shashin-to and Dai-jyoki-to are ameliorative to the hypertension in sympathetic system dominance and Shinbu-to is occasionally dangerous to it.
Sanae
F
F
Department of Medicine, Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. f-sanae@hokuriku-u.ac.jp
Komatsu
Y
Y
Amagaya
S
S
Chisaki
K
K
Hayashi
H
H
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D020835:Medicine, Kampo; D051381:Rats; D017208:Rats, Wistar; D013806:Theophylline / Q000494:pharmacology*
D000959:Antihypertensive Agents; D013806:Theophylline