[The quantitative patterns of the modified one-center bioreceptor model].
A modified one site model of the bioreceptor have been used to estimate quantitatively the phenomenon of the full agonism. Threshold phenomenon, spare receptors and linear dependence of the biological effect on concentration of complex agonist-receptor has been determinate by the general correlation equations. The equations of one site model provides a good fit to the experimental curves "dose-response" for the full agonists and allows to calculate the value of space receptors. The model includes occupancy Clark's theory and law "all or nothing". The interaction of acetylcholine and aklyltrimethylammonium salts with muscarinic acetylholine receptors is analysed as an example of use of this equation.
Poltorakov
A P
AP
N. N. Semenov Institute of Chemical Physics, Russian Academy of Science, Moscow, Russia. poltorakov@mtu-net.ru
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000819:agonists* / Q000187:drug effects
D011956:Receptors, Cell Surface
Kolichestvennye zakonomernosti modifitsirovannoĭ odnotsentrovoĭ modeli bioretseptora.