[The protective effect of omega-3 polyunsaturated fatty acids on the activity of the isolated rat heart during myocardial ischemia-reperfusion].
It was produced plant-derived product, an omega-3 acid-enriched substrate (64%). In our study we tested the influence of this preparation, which is supposed a membrane-modifying agent, on the processes of damage to the isolated heart under conditions of ischemia-reperfusion. Animals took this substrate as nutrient addition to usually everyday diet. We assumed disorders in cardiodynamics and contractile functions of the myocardium (we measured a perfusion pressure in coronary vessel, left ventricular pressure and dp/dt) and in structure of cardiomyocytes. All mentioned parameters was much better after ischemia-reperfusion in hearts from animals which took an omega-3 acid-enriched substrate in course of 4 week before experiments than in hearts from control animals. Conclusions. Omega-3 polyunsaturated acids exert protective effect on functioning and structure of the isolated rat heart during ischemia-reperfusion.
Kvochina
L I
LI
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Tumanovs'ka
L V
LV
Marchenko
H I
HI
Moĭbenko
O O
OO
Butovych
I A
IA
Kharchenko
O V
OV
D000818:Animals; D004042:Dietary Fats, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D015525:Fatty Acids, Omega-3 / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015428:Myocardial Reperfusion Injury / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000648:ultrastructure; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats
D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D010938:Plant Oils
Protektornyĭ vplyv omeha-3 polinenasychenykh zhyrnykh kyslot na diial'nist' izol'ovanoho sertsia shchura pid chas ishemiï-reperfuziï miokarda.