title: Postnatal growth rate and gonadal development in circadian tau mutant hamsters reared in constant dim red light.
abstract: The role of the circadian clock in the reproductive development of Syrian hamsters (Mesocricetus auratus was examined in wild type and circadian tau mutant hamsters reared from birth to 26 weeks of age under constant dim red light. Testis diameter and body weights were determined at weekly intervals in male hamsters from 4 weeks of age. In both genotypes, testicular development, subsequent regression and recrudescence exhibited a similar time course. The age at which animals displayed reproductive photosensitivity, as exhibited by testicular regression, was unrelated to circadian genotype (mean +/- SEM: 54 +/- 3 days for wild type and 59 +/- 5 days for tau mutants). In contrast, our studies revealed a significant impact of the mutation on somatic growth, such that tau mutants weighed 18% less than wild types at the end of the experiment. Our study reveals that the juvenile onset of reproductive photoperiodism in Syrian hamsters is not timed by the circadian system.
authors.affiliation: School of Biological Sciences, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Lucas
authors.forename: J A
authors.initials: JA
authors.lastname: Stirland
authors.forename: Y N
authors.initials: YN
authors.lastname: Mohammad
authors.forename: A S
authors.initials: AS
authors.lastname: Loudon
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D002940:Circadian Rhythm / Q000502:physiology*; D006224:Cricetinae; D003624:Darkness; D005838:Genotype; D008297:Male; D008647:Mesocricetus / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D009154:Mutation; D017440:Photoperiod; D013737:Testis / Q000254:growth & development* / Q000502:physiology; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins