[The nature of the respiratory tract microflora and the immunity indices in a severe form of bronchial asthma in children].
65 children with the severe course of bronchial asthma (BA) were examined. The character of respiratory tract microflora, humoral immunity characteristics, mediators, of inflammation and pathomorphological features of the bronchial tree during the severe course of BA in children at the period of remission were studied. The specific features of the colonization of the bronchial tree by microflora in the severe form of BA were established. The severe course of BA in children at the period of remission was characterized by a higher content of tumor necrosis factor and an increase in the lysozyme activity of bronchoalveolar fluid. Disturbances in the proportion of cAMP and cGMP in smooth muscles and an increase in the number of apudocytes containing adrenalin and serotonin may probably be one of the mechanisms of bronchial hyperreactivity.
Fedorov
I A
IA
Medical Academy, Chelyabinsk, Russia.
Teplova
S N
SN
Zhakov
Ia I
IaI
Stepanov
O G
OG
Giniatullin
R U
RU
D000208:Acute Disease; D000293:Adolescent; D000917:Antibody Formation; D001249:Asthma / Q000276:immunology* / Q000382:microbiology* / Q000473:pathology; D001419:Bacteria / Q000302:isolation & purification; D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D012137:Respiratory System / Q000382:microbiology*; D015003:Yeasts / Q000302:isolation & purification
Kharakter mikroflory respiratornogo trakta i pokazateli immuniteta pri tiazheloĭ forme bronkhial'noĭ astmy u deteĭ.