title: Two consecutive pregnancies during inadvertent gonadotropin-releasing hormone agonist desensitization.
abstract: OBJECTIVE
  To describe two consecutive spontaneous pregnancies during luteal-phase down-regulation with a GnRH-a.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University-affiliated reproductive medicine unit.
  
  
  METHODS
  A 33-year-old woman with a history of failed uterine tubal reanastomosis.
  
  
  METHODS
  Four IVF cycles.
  
  
  METHODS
  Pregnancy.
  
  
  RESULTS
  The patient had two spontaneous pregnancies during luteal-phase down-regulation.
  
  
  CONCLUSIONS
  Although midluteal administration of GnRH-a is not established as a treatment, there might be a beneficial effect on the endometrium via the medication's evoked gonadotropin flare.
authors.affiliation: Monash-IVF, Epworth Hospital, Melbourne, Victoria, Australia. peter.platteau@az.vub.ac.be
authors.forename: P
authors.initials: P
authors.lastname: Platteau
authors.forename: M
authors.initials: M
authors.lastname: Gabbe
authors.forename: M
authors.initials: M
authors.lastname: Talbot
authors.forename: D
authors.initials: D
authors.lastname: Healy
mesh_terms: D000328:Adult; D015536:Down-Regulation; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D008183:Luteal Phase; D011247:Pregnancy / Q000187:drug effects
chemical_list: D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide