title: Cerebral regions associated with verbal response initiation, suppression and strategy use.
abstract: Cerebral activation associated with performance on a novel task involving two conditions was investigated with functional magnetic resonance imaging (fMRI). In the response initiation condition, subjects nominated the general superordinate category to which each of a series of exemplars (concrete nouns) belonged. In the response suppression condition, subjects were required to nominate a general superordinate category to which each exemplar did not belong, with the instruction that they were not to nominate the same category response twice in a row. Both conditions produced distinct patterns of activation relative to an articulation control condition employing identical stimuli. When initiation and suppression conditions were directly compared, response suppression produced activation in the right frontal pole, orbital frontal cortex and anterior cingulate, left dorsolateral prefrontal cortex and posterior cingulate, and bilaterally in the precuneus, visual association cortex and cerebellum. Response latencies were significantly longer in the suppression condition. Two broadly-defined strategies associated with the correct production of words during the suppression condition were a self-ordered selection from among the superordinate categories identified during the first section of the task and the generation of novel category responses. The neuroanatomical correlates of response initiation, suppression and strategy use are discussed, as are the respective roles of response suppression and strategy generation.
authors.affiliation: Centre for Magnetic Resonance, The University of Queensland, Queensland, QLD 4072, Australia. greig.dezubicaray@cmr.uq.edu.au
authors.forename: G I
authors.initials: GI
authors.lastname: de Zubicaray
authors.forename: F O
authors.initials: FO
authors.lastname: Zelaya
authors.forename: C
authors.initials: C
authors.lastname: Andrew
authors.forename: S C
authors.initials: SC
authors.lastname: Williams
authors.forename: E T
authors.initials: ET
authors.lastname: Bullmore
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D017352:Echo-Planar Imaging; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology; D012032:Refractory Period, Electrophysiological; D013060:Speech / Q000502:physiology*; D014936:Word Association Tests