title: Mechanisms to explain pancreatic dysfunction in cystic fibrosis.
abstract: This article focuses on three potential mechanisms by which pancreatic dysfunction occurs in cystic fibrosis. These include (1) obstruction of pancreatic ducts by inspissated plugs, (2) inhibition of endocytosis in acinar cells, and (3) imbalance in membrane lipids in cystic fibrosis regulated cells. Any of these abnormalities alone or in combination may explain the development of pancreatic exocrine insufficiency.
authors.affiliation: Pancreas Center, Beth Israel Deaconess Medical Center, Boston, Massachussachusetts, USA. sfreedma@caregroup.havard.edu
authors.forename: S D
authors.initials: SD
authors.lastname: Freedman
authors.forename: P
authors.initials: P
authors.lastname: Blanco
authors.forename: J C
authors.initials: JC
authors.lastname: Shea
authors.forename: J G
authors.initials: JG
authors.lastname: Alvarez
mesh_terms: D003550:Cystic Fibrosis / Q000503:physiopathology*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D010188:Exocrine Pancreatic Insufficiency / Q000503:physiopathology*; D006801:Humans; D008563:Membrane Lipids / Q000502:physiology; D010179:Pancreas / Q000503:physiopathology*; D010183:Pancreatic Ducts / Q000503:physiopathology
chemical_list: C505032:CFTR protein, human; D008563:Membrane Lipids; D019005:Cystic Fibrosis Transmembrane Conductance Regulator