Evaluation of bioartificial pancreas function made from sodium alginate and poly-L-lisine microcapsules settled with viable pancreatic islets.
The possibility of transplantation of immuno-isolated viable pancreatic islets is a promising alternative for treatment diabetic patients. To establish the value of the artificial prosthesis made from settled with viable pancreatic islets microcapsulated using sodium alginate and poly-L-lisine, the glucose plasma levels were analyzed versus time after implantation into peritoneal cavity of rats or mice with alloxan-induced diabetes. The proper function of the bio-artificial pancreas manifested in normalization of glucose plasma level has been observed from 14 to 21 days after implantation in diabetic mice and rats.
Gamian
E
E
Department of Pathological Anatomy, Medical University of Wrocław, Poland.
Kochman
A
A
Rabczyński
J
J
D000464:Alginates; D000496:Alloxan; D000818:Animals; D002214:Capsules; D003921:Diabetes Mellitus, Experimental / Q000473:pathology / Q000628:therapy*; D005260:Female; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D007515:Islets of Langerhans; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D010179:Pancreas / Q000473:pathology; D019397:Pancreas, Artificial; D011107:Polylysine; D051381:Rats; D011915:Rats, Inbred BUF
D000464:Alginates; D002214:Capsules; D006603:Hexuronic Acids; D011107:Polylysine; D000496:Alloxan; D020723:Glucuronic Acid