Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects.
Nedocromil sodium inhibits the response to exercise-induced asthma (EIA). Mannitol given as a powder by inhalation is an osmotic stimulus that identifies EIA. We studied the acute effect of nedocromil on airway responsiveness to mannitol in 24 asthmatic subjects. After a control day, nedocromil (8 mg) or its placebo was administered randomized, double blind, 10 min before a challenge with progressively increasing doses of mannitol. Nedocromil inhibited the response to mannitol and there was a significant increase in the dose of mannitol required to cause a 15% reduction in FEV(1) (PD(15)) after nedocromil 409 (316,503) mg compared with placebo 156 (106,229) mg (p < 0.001). In the presence of nedocromil 12 subjects no longer recorded a 15% decrease in FEV(1) in response to mannitol. The remaining 12 required a significantly greater dose of mannitol to achieve a 15% decrease in FEV(1) after nedocromil. Following nedocromil, a plateau in responsiveness to mannitol was observed in 14 subjects. Nedocromil significantly inhibits the responsiveness to inhaled mannitol in asthmatic subjects.
Brannan
J D
JD
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia.
Anderson
S D
SD
Freed
R
R
Leuppi
J D
JD
Koskela
H
H
Chan
H K
HK
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008353:Mannitol; D008875:Middle Aged; D017835:Nedocromil / Q000008:administration & dosage*; D011292:Premedication
D017835:Nedocromil; D008353:Mannitol