An evaluation of interleukin genes fails to identify clear susceptibility loci for multiple sclerosis.
Differential expression of interleukins may influence susceptibility to inflammatory diseases such as MS. IL-1a production is increased in MS patients during acute relapse, IL-2 receptor (IL-2R) secretion correlates with disease activity in several inflammatory disorders and is variable in MS. Both IL-4 and IL-10 expression vary significantly with relapse/remission in MS and IL-9 is postulated to inhibit steroid-induced apoptosis. To examine the influence of interleukin (IL) genes on MS susceptibility and clinical course, gene association studies using separate polymorphic microsatellite markers for il-1 alpha, il-2, il-2r beta, il-4 il-9 and il-10 were performed, incorporating 150-177 relapsing-remitting or secondary progressive MS (RR/SPMS) patients, 100-110 primary progressive (PPMS) patients and 152-210 controls. No significant differences existed in allele frequencies between either MS group and controls for any of the interleukin microsatellite markers studied, nor were statistically significant differences observed in PPMS vs. RR/SPMS for any marker. These data indicate that the IL-1 alpha, IL-2, IL-2R beta, IL-4, IL-9 and IL-10 genes are unlikely to be susceptibility loci for MS in this population.
McDonnell
G V
GV
Northern Ireland Neurology Service, Royal Victoria Hospital, Northern Ireland, Belfast, UK.
Kirk
C W
CW
Hawkins
S A
SA
Graham
C A
CA
D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004247:DNA / Q000032:analysis; D005260:Female; D005456:Fluorescent Dyes; D020022:Genetic Predisposition to Disease; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D020528:Multiple Sclerosis, Chronic Progressive / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D005456:Fluorescent Dyes; D007378:Interleukins; D004247:DNA