title: Porous apatite-wollastonite glass-ceramic as an intramedullary plug.
abstract: We evaluated the efficacy and biocompatibility of porous apatite-wollastonite glass ceramic (AW-GC) as an intramedullary plug in total hip replacement (THR) for up to two years in 22 adult beagle dogs. Cylindrical porous AW-GC rods (70% porosity, mean pore size 200 microm) were prepared. Four dogs were killed at 1, 3, 6 and 12 months each and six at 24 months after implantation. Radiological evaluation confirmed the efficacy of porous AW-CG as an intramedullary plug. Histological evaluation showed osteoconduction at one month and resorption of the porous AW-GC, which was replaced by newly-formed bone, at 24 months. Our findings indicate that porous AW-GC can be used clinically as an intramedullary plug in THR.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Iida
authors.forename: K
authors.initials: K
authors.lastname: Ido
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001031:Apatites; D019644:Arthroplasty, Replacement, Hip / Q000379:methods; D001843:Bone Cements / Q000627:therapeutic use; D001853:Bone Marrow; D018786:Bone Substitutes; D017610:Calcium Compounds; D002516:Ceramics; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005269:Femur / Q000187:drug effects / Q000648:ultrastructure; D020007:Implants, Experimental; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D017640:Silicates; D013997:Time Factors
chemical_list: D001031:Apatites; D001843:Bone Cements; D018786:Bone Substitutes; D017610:Calcium Compounds; D017640:Silicates; C023506:Glass ceramics; C031293:calcium silicate