title: Rapid clearance of human immunodeficiency virus type 1 from ventricular cerebrospinal fluid during antiretroviral treatment.
abstract: To understand the pathogenesis of human immunodeficiency virus-induced neuropathology, it is critical to know the dynamics of viral replication in the central nervous system. Viral decay kinetics were mathematically analyzed from multiple serial specimens of ventricular cerebrospinal fluid and plasma during antiretroviral therapy in a patient with asymptomatic human immunodeficiency virus infection and an external ventricular catheter for hydrocephalus. A rapid exponential decay of virus with an elimination half-life of 4.2 days in ventricular cerebrospinal fluid and 2.3 days in plasma was found. Sequencing the V3 loop-encoding envelope gene of virus in both compartments revealed high sequence homology. The combined data suggest that virus in ventricular cerebrospinal fluid is at least partly contributed by rapidly replicating virus-producing cells recruited from the circulation.
authors.affiliation: Department of Neurology, University Hospital Hamburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Eggers
authors.forename: H J
authors.initials: HJ
authors.lastname: Stuerenburg
authors.forename: T
authors.initials: T
authors.lastname: Schafft
authors.forename: B
authors.initials: B
authors.lastname: Zöllner
authors.forename: H H
authors.initials: HH
authors.lastname: Feucht
authors.forename: H J
authors.initials: HJ
authors.lastname: Stellbrink
authors.forename: J
authors.initials: J
authors.lastname: van Lunzen
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D010802:Phylogeny; D013997:Time Factors; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents