title: Multiple inversion recovery MR subtraction imaging of human ventilation from inhalation of room air and pure oxygen.
abstract: The feasibility of MR subtraction imaging of lung ventilation using air against oxygen using a multiple inversion recovery half-Fourier single-shot turbo spin echo (MIR-HASTE) sequence was investigated. Eight healthy, nonsmoking volunteers (3 males, 5 females; from 27 to 48 years of age) were studied on a 1.5 T MR unit. The ventilation image was obtained from the subtraction of the images acquired with the subject inhaling room air and 100% oxygen. By suppressing the signal from subcutaneous fat and thoracic muscle, MIR-HASTE improved the subtraction of signal arising from background tissues. Lung parenchyma, pulmonary veins, descending aorta, spleen, and kidney showed high signal difference, but pulmonary arteries exhibited minimal signal difference. Because of minimal signal change in the pulmonary arteries after inhalation of 100% oxygen, the average signal decreases in the left and right lungs including hilus and periphery amounted to only 19.4+/-4.5 and 20.2+/-3.4%, respectively, compared with regional averages of 23.6+/-5.4 and 24.1+/-3.1% for both lung peripheries alone. Magn Reson Med 43:913-916, 2000.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard School of Medicine, Boston, Massachusetts 02215, USA. vmmai@caregroup.harvard.edu
authors.forename: V M
authors.initials: VM
authors.lastname: Mai
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: A A
authors.initials: AA
authors.lastname: Bankier
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000388:Air; D005260:Female; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000008:administration & dosage*; D011659:Pulmonary Gas Exchange; D012016:Reference Values; D012119:Respiration; D012680:Sensitivity and Specificity
chemical_list: D010100:Oxygen