Statistico-mechanics of chromosomal insertions in human cancers.
The paper discusses a mechanism for segmental insertions (ins) between two chromatids. In human cancers, such rearrangements are significantly less frequent than reciprocal translocations (rt). Regarding the clinical incidence of ins versus rt, the proposed dynamics is more satisfactory than the random mutation hypothesis.
Matioli
G T
GT
USC Medical School, Los Angeles, CA 90033, USA.
D002869:Chromosome Aberrations; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic