title: Pain and pain treatment in AIDS patients: a longitudinal study.
abstract: To determine the prevalence, incidence, and characteristics of pain connected with AIDS, 95 AIDS patients were enrolled in a prospective longitudinal study and interviewed every six months during a 2-year period or until death. The overall incidence of pain was 88%, and 69% of the patients suffered from constant pain interfering with daily living to a degree described as moderate or severe. The most common pain localizations were: extremities (32%), head (24%), upper gastrointestinal tract (23%) and lower gastrointestinal tract (22%). Pain conditions were connected to various opportunistic infections, Kaposi's sarcoma, or lymphoma. Pain in the extremities was predominantly of neuropathic origin (21%). The number of pain localizations increased significantly as death approached (0.8 +/- 1. 0 vs. 1.4 +/- 0.8, p = 0.03). The survival rate for patients without pain at entry was significantly higher than the survival rate of patients in pain, probably related to differences in the duration of AIDS at the time of inclusion. Sustained-release morphine preparations were prescribed in 29% of the patients. Of 39 patients (41%) who died in the department, 7 patients were prescribed continuous intravenous morphine infusion for pain treatment in the terminal phase and 20 patients received short-acting opioids. According to the Pain Management Index (PMI), the patients were insufficiently treated at the beginning of the study. Although the PMI improved significantly during the observation period, the patients felt that pain was not taken seriously by the physicians. However, the patients were convinced that treatment was optimal and, therefore, only 9% of the patients were dissatisfied. Patients were reluctant to take analgesics, primarily because of fear of addiction.
authors.affiliation: Department of Infectious Diseases and H:S Multidisciplinary Pain Center, National Hospital, Copenhagen, Denmark.
authors.forename: L M
authors.initials: LM
authors.lastname: Frich
authors.forename: F M
authors.initials: FM
authors.lastname: Borgbjerg
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology* / Q000628:therapy*; D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D009294:Narcotics / Q000627:therapeutic use; D010146:Pain / Q000453:epidemiology / Q000503:physiopathology; D010166:Palliative Care; D015995:Prevalence; D011446:Prospective Studies
chemical_list: D009294:Narcotics; D009020:Morphine