title: Natural and synthetic inhibitors of the tumor-associated serine protease urokinase-type plasminogen activator.
authors.affiliation: Klinische Forschergruppe der Frauenklinik der Technischen Universität München, Klinikum rechts der Isar, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Magdolen
authors.forename: N
authors.initials: N
authors.lastname: Arroyo de Prada
authors.forename: S
authors.initials: S
authors.lastname: Sperl
authors.forename: B
authors.initials: B
authors.lastname: Muehlenweg
authors.forename: T
authors.initials: T
authors.lastname: Luther
authors.forename: O G
authors.initials: OG
authors.lastname: Wilhelm
authors.forename: U
authors.initials: U
authors.lastname: Magdolen
authors.forename: H
authors.initials: H
authors.lastname: Graeff
authors.forename: U
authors.initials: U
authors.lastname: Reuning
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
mesh_terms: D000578:Amidines / Q000138:chemical synthesis / Q000494:pharmacology; D000584:Amiloride / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001550:Benzamidines / Q000737:chemistry / Q000494:pharmacology; D006146:Guanidines / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D015394:Molecular Structure; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010641:Phenotype; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D017396:Plasminogen Activator Inhibitor 2 / Q000172:deficiency / Q000235:genetics / Q000494:pharmacology / Q000502:physiology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism; D055293:Receptors, Urokinase Plasminogen Activator; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D015843:Serpins / Q000502:physiology*; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors*
chemical_list: C097398:4-iodine-benzo(b)thiophene-2-carboxamidine; D000578:Amidines; C119100:B 623; D001550:Benzamidines; D006146:Guanidines; D009363:Neoplasm Proteins; D017395:Plasminogen Activator Inhibitor 1; D017396:Plasminogen Activator Inhibitor 2; C524899:Plaur protein, mouse; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D013876:Thiophenes; C026943:phenylguanidine; C006500:4-aminobenzamidine; D000584:Amiloride; D014568:Urokinase-Type Plasminogen Activator