The adaptor hypothesis revisited.
As originally postulated in Crick's Adaptor hypothesis, the faithful synthesis of proteins from messenger RNA is dependent on the presence of perfectly acylated tRNAs. The hypothesis also suggested that each aminoacyl-tRNA would be made by a unique enzyme. Recent data have now forced a revision of this latter point, with an increasingly diverse array of enzymes and pathways being implicated in aminoacyl-tRNA synthesis. These unexpected findings have far-reaching implications for our understanding of protein synthesis and its origins.
Ibba
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Center for Biomolecular Recognition, Dept of Medical Biochemistry and Genetics, Laboratory B, The Panum Institute, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark.
Becker
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Stathopoulos
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Tumbula
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Söll
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D000604:Amino Acyl-tRNA Synthetases / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D019843:Archaeal Proteins / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D008250:Lysine-tRNA Ligase / Q000145:classification / Q000378:metabolism; D008957:Models, Genetic; D010802:Phylogeny; D014176:Protein Biosynthesis; D012345:RNA, Transfer, Amino Acid-Specific / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
D019843:Archaeal Proteins; D012345:RNA, Transfer, Amino Acid-Specific; D000604:Amino Acyl-tRNA Synthetases; C019975:cysteinyl-tRNA synthetase; D008250:Lysine-tRNA Ligase