title: Agelasine F from a Philippine Agelas sp. sponge exhibits in vitro antituberculosis activity.
abstract: Marine sponge samples were collected in Baler, Aurora, Philippines, and extracts were tested for in vitro antituberculosis activity. An orange Agelas sp. sponge yielded the known compound, agelasine F, which inhibited some drug resistant strains of Mycobacterium tuberculosis in vitro at concentrations as low as 3.13 micrograms/ml. Activity against M. tuberculosis residing within macrophages required concentrations of 13-22 micrograms/ml which was below the IC50 for Vero cells (34 micrograms/ml).
authors.forename: G C
authors.initials: GC
authors.lastname: Mangalindan
authors.forename: M T
authors.initials: MT
authors.lastname: Talaue
authors.forename: L J
authors.initials: LJ
authors.lastname: Cruz
authors.forename: S G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: L B
authors.initials: LB
authors.lastname: Adams
authors.forename: A D
authors.initials: AD
authors.lastname: Richardson
authors.forename: C M
authors.initials: CM
authors.lastname: Ireland
authors.forename: G P
authors.initials: GP
authors.lastname: Concepcion
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000302:isolation & purification / Q000494:pharmacology*; D006146:Guanidines / Q000302:isolation & purification / Q000494:pharmacology*; D008264:Macrophages / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D011687:Purines
chemical_list: D000995:Antitubercular Agents; D006146:Guanidines; D011687:Purines; C412407:agelasine F