Effect of leptin in platelet and endothelial cells. Obesity and arterial thrombosis.
We demonstrated that leptin showed effects on both platelets and endothelial cells through its functional receptor. These effects are the vector to inducing thrombotic tendency. Leptin concentrations used in our experiments correspond to that of leptin in the circulation of obese individuals. Thus we suggest that increased leptin may act as a risk factor for thrombosis in obese individuals.
Maruyama
I
I
Department of Laboratory and Molecular Medicine, Kagoshima University School of Medicine, Japan.
Nakata
M
M
Yamaji
K
K
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001161:Arteriosclerosis / Q000097:blood / Q000503:physiopathology*; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D001798:Blood Proteins / Q000378:metabolism; D002352:Carrier Proteins / Q000097:blood / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000494:pharmacology*; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D010766:Phosphorylation; D010974:Platelet Aggregation / Q000187:drug effects; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D018180:Thrombomodulin / Q000378:metabolism
D001798:Blood Proteins; D002352:Carrier Proteins; C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D018180:Thrombomodulin; D000244:Adenosine Diphosphate