title: Left ventricular function in colon cancer patients receiving adjuvant fluoro-folate chemotherapy: an echocardiographic study.
abstract: Cardiotoxicity has been reported with increasing frequency after 5-FU administration. Since 5-FU-based regimens are increasingly used as adjuvant treatment for resected colon cancer patients, this carries a potential increased risk of cardiotoxicity. In the present study, we evaluated if fluoro-folate chemotherapy has any effect on left ventricular (LV) diastolic function in resected colon cancer. Twenty-five resected colon cancer patients receiving adjuvant fluoro-folate chemotherapy, were prospectively studied. Both digitized M-mode and Doppler echocardiography were performed, in order to investigate different aspects of LV diastolic function. None of the studied parameters was influenced by chemotherapy administration. Indeed, values recorded at the end of the 6-month treatment and 6 months later were not statistically different from baseline values. This study suggests that the use of fluoro-folate chemotherapy in otherwise normal subjects carries a very low risk of severe cardiotoxicity.
authors.affiliation: 'C. Golgi' Institute of General Pathology, University of Pavia, I-27100 Pavia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Balloni
authors.forename: C
authors.initials: C
authors.lastname: Porta
authors.forename: S
authors.initials: S
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Gola
authors.forename: P
authors.initials: P
authors.lastname: Pugliese
authors.forename: S
authors.initials: S
authors.lastname: Ferrari
authors.forename: A
authors.initials: A
authors.lastname: Bovio
authors.forename: M
authors.initials: M
authors.lastname: Danova
authors.forename: A
authors.initials: A
authors.lastname: Riccardi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects; D004452:Echocardiography / Q000187:drug effects*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013599:Systole / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D005472:Fluorouracil