title: Single-breath measurements of pulmonary oxygen uptake and gas flow rates for ventilator management in ARDS.
abstract: Monitoring data in critical care and anesthesiology should be displayed to present a rapid and easily comprehensible definition of the patient's clinical status. A graphic computer display of the analog output of gas flow rates and the O(2) and CO(2) concentrations of respiratory gases profiles the expired breath for an estimation of pulmonary function and gas exchange. An estimate of pulmonary perfusion, cardiac output, and the general adequacy of cardiovascular circulation is obtained from the computer calculation of O(2) uptake and CO(2) elimination, dead space, and alveolar ventilation. Adjunctive data from the spirometric measurements of airway pressures, volumes, and compliance, supplemented by hemodynamic monitoring, aids in the diagnosis of physiologic changes. For > 10 years, we have used this system to monitor patients who are anesthetized, sedated, and receiving mechanical ventilation during anesthesia and surgery, and recently have extended the technique to intensive care areas. Our experience has shown good correlation of changes in the computer-assisted expired breath analysis with coinciding clinical events, including upper airway obstruction, bronchospasm, and alveolar volume/pulmonary capillary blood flow impairment. To demonstrate the use of this system, we describe the ventilator management for a patient with severe ARDS. In this patient, changes in ventilator management, including pressure control ventilation, improved pulmonary O(2) uptake (mean, 18.7 vs 8.5 mL/breath), CO(2) elimination (mean, 17 vs 13 mL/breath), and compliance (mean, 29.7 vs 19.0 mL/cm H(2)O), were compared with intermittent mandatory ventilation.
authors.affiliation: Department of Anesthesiology, Division of Critical Care Medicine, University of North Carolina at Chapel Hill, 27599-7010, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Szalados
authors.forename: F E
authors.initials: FE
authors.lastname: Noe
authors.forename: M G
authors.initials: MG
authors.lastname: Busby
authors.forename: P G
authors.initials: PG
authors.lastname: Boysen
mesh_terms: D002302:Cardiac Output; D006801:Humans; D008170:Lung Compliance / Q000502:physiology; D008176:Lung Volume Measurements; D008432:Mathematical Computing; D010100:Oxygen / Q000097:blood*; D011175:Positive-Pressure Respiration; D011650:Pulmonary Alveoli / Q000503:physiopathology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000503:physiopathology / Q000628:therapy*; D013813:Therapy, Computer-Assisted; D014692:Ventilation-Perfusion Ratio / Q000502:physiology*
chemical_list: D010100:Oxygen