title: Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
abstract: Preliminary SAR studies on the side chain of a new class of antiviral nucleosides have shown that terminal substitution in the side-chain, with a halogen atom, lead to potent and highly specific anti-VZV agents.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, UK.
authors.forename: A
authors.initials: A
authors.lastname: Brancale
authors.forename: C
authors.initials: C
authors.lastname: McGuigan
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D006219:Halogens / Q000737:chemistry*; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D006219:Halogens; D009705:Nucleosides