title: Heterotopic bone formation in two cases of colon carcinoma.
abstract: Heterotopic bone formation is rare in the gastrointestinal tract. We here present the clinical and pathologic details of a 56-year-old male patient with mucinous adenocarcinoma of the colon and a 70-year-old male patient with colon metastasis previously operated on for signet-ring-cell carcinoma of the stomach who was treated with radiotherapy postoperatively. Both of them showed diffuse bone metaplasia. Heterotopic bone formation is usually present with mucin-producing benign or malignant tumors. The pathogenesis of osseous metaplasia is not well known; however, it is speculated that the extravasation of mucin may have a stimulatory role.
authors.affiliation: Dept. of Pathology, Faculty of Medicine, University of Abant Izzet Baysal, Düzce-Bolu, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Alper
authors.forename: N
authors.initials: N
authors.lastname: Akyürek
authors.forename: T E
authors.initials: TE
authors.lastname: Patiroğlu
authors.forename: O
authors.initials: O
authors.lastname: Yüksel
authors.forename: O
authors.initials: O
authors.lastname: Belenli
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000150:complications*; D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000150:complications* / Q000556:secondary; D003106:Colon / Q000473:pathology*; D003110:Colonic Neoplasms / Q000150:complications* / Q000556:secondary; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology* / Q000473:pathology