[Comparative study of anticoagulants obtained from various extracts of Paeonia anomala].
We have established that extracts prepared from various parts of the root of Paeonia anomala (bark and wood) have anticoagulant activity as indicated by the criterion of longer recalcification time of the normal rat blood plasma. This anticoagulant activity is due to the presence of heparin-like fragments in the preparations, which follows from the results of biochemical analysis and results of studies on the functional state of the mast cell population. Preparations from the peony root bark retain their anticoagulant properties in the circulatory system for 1.5 h after intravenous administration, similarly to heparin of the animal origin.
Liapina
L A
LA
Moscow State University, Vorob'evy gory, Russia.
Kondashevskaia
M V
MV
Ziadetdinova
G A
GA
Uspenskaia
M S
MS
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects; D008643:Mesentery / Q000098:blood supply / Q000166:cytology / Q000187:drug effects; D008833:Microcirculation; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D010936:Plant Extracts; D006493:Heparin
Sravnitel'nye issledovaniia antikoagulantov iz razlichnykh ékstraktov Paeonia anomalia.