title: [Physiological effects of destruction of the tip links of cochlear hair cells. Significance for noise-induced hearing loss].
abstract: Sound overexposure is known to cause damage to cochlear structures and can induce permanent or temporary hearing loss and tinnitus. Perhaps the most sensitive of these structures to sound overexposure are the tip links. In this paper the electrophysiological effects of pharmacological destruction of the tip links of outer hair cells was investigated. Outer hair cells treated with elastase (20 U/mL) or BAPTA (5 mM) no longer responded to sinusoidal stimuli. In contrast to common belief, transduction channels opened due to loss of tip links. Such opened channels can allow K+ and Ca2+ to enter the cell from the endolymphatic space and cold lead to permanent depolarization. This influx of cations caused by loss of tip links, together with the subsequent hair-cell depolarization, might be a source of sensorineural hearing loss and tinnitus associated with acoustic trauma.
authors.affiliation: Universitäts-HNO-Klinik Tübingen. jens.meyer@uni-tuebingen.de
authors.forename: J
authors.initials: J
authors.lastname: Meyer
authors.forename: A W
authors.initials: AW
authors.lastname: Gummer
mesh_terms: D000818:Animals; D001305:Auditory Fatigue / Q000502:physiology*; D015220:Calcium Channels / Q000502:physiology; D002478:Cells, Cultured; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000503:physiopathology*; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D008564:Membrane Potentials / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014012:Tinnitus / Q000503:physiopathology
chemical_list: D015220:Calcium Channels; D015221:Potassium Channels
vernacular_title: Physiologische Auswirkungen einer Zerstörung der Tip-Links kochleärer Haarsinneszellen. Bedeutung für die lärminduzierte Schädigung de Gehörs.