The metabolism and excretion of [14c] 2- and 4-chlorobenzoic acids in the rat.
The metabolic fate of [14C]-labelled 2 and 4-chlorobenzoic acids (2- and 4-CBA) has been determined in the rat following intraperitoneal (i.p.) administration at 100 mg/kg to male rats. The major route of elimination for both 2-and 4-CBA was urine with > 80%, of the dose recovered in the initial 0-24 h after administration. Glycine conjugation was found to be the dominant metabolic fate for both [14C] 2- and 4-CBA however, the position of chloro substitution had a clear effect on the extent of metabolism via this route with ortho substitution reducing the extent of metabolism via this pathway.
Blackledge
C A
CA
Deparment of Chemistry, Birkbeck College, London, UK.
Partridge
E A
EA
Wilson
I D
ID
Nicholson
J K
JK
D000818:Animals; D002723:Chlorobenzoates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine; D002855:Chromatography, Thin Layer; D005243:Feces / Q000737:chemistry; D005998:Glycine / Q000378:metabolism; D007274:Injections, Intraperitoneal; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D051381:Rats
D002723:Chlorobenzoates; C060415:2-chlorobenzoic acid; C040768:4-chlorobenzoic acid; D005998:Glycine