title: A prospective study of body composition changes in children with cystic fibrosis.
abstract: Recent cross-sectional studies of children with cystic fibrosis (CF) have shown an improvement in their growth with improved nutritional status, but there are only a few longitudinal studies in this population. A four-year prospective study was conducted in 25 children with CF and 26 controls, ages 5 to 10 years at baseline, to describe changes in body composition using three independent methods of assessment: skinfold thickness, total body water by deuterium dilution, and total body electrical conductivity (TOBEC). The statural growth of the boys with CF was slower than that of the control boys. Using different methods, the fat-free mass and fat-mass increases were shown to be slower in boys with CF than in controls. These differences were less significant in girls. Despite comprehensive care, the growth of boys with CF may still not be optimal, as observed longitudinally.
authors.affiliation: Division of Gastroenterology and Nutrition, Children's Hospital of Philadelphia, Pennsylvania 19104-4399, USA. nstettle@cceb.med.upenn.edu
authors.forename: N
authors.initials: N
authors.lastname: Stettler
authors.forename: D A
authors.initials: DA
authors.lastname: Kawachak
authors.forename: L L
authors.initials: LL
authors.lastname: Boyle
authors.forename: K J
authors.initials: KJ
authors.lastname: Propert
authors.forename: T F
authors.initials: TF
authors.lastname: Scanlin
authors.forename: V A
authors.initials: VA
authors.lastname: Stallings
authors.forename: B S
authors.initials: BS
authors.lastname: Zemel
mesh_terms: D001823:Body Composition / Q000502:physiology*; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000503:physiopathology*; D003903:Deuterium; D004553:Electric Conductivity; D005260:Female; D006128:Growth; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011865:Radioisotope Dilution Technique; D012016:Reference Values; D012885:Skinfold Thickness
chemical_list: D003903:Deuterium