[A cultured concentrated inactivated vaccine against tick-borne encephalitis studied during the immunization of children and adolescents].
The word deals with the results obtained in the study of the reactogenicity and immunological activity of concentrated and inactivated tissue-culture tick-borne encephalitis vaccine, manufactured by the Chumakov Institute of Poliomyelitis and Viral Encephalitides, in the immunization of children and adolescents. The vaccine proved to be moderately reactogenic and exhibited pronounced immunological activity. In 91.5% of the immunized children the fourfold increase of the antibody level was observed. On the basis of the data obtained in this study the tick-borne encephalitis vaccine was recommended for use in medical practice for the prophylaxis of tick-borne encephalitis among children and adolescents.
Pavlova
L I
LI
Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, Moscow, Russia.
Gorbunov
M A
MA
Vorob'eva
M S
MS
Karavanov
A S
AS
Grachev
V P
VP
Ladyshenskaia
I P
IP
Rasshchepkina
M N
MN
Mel'nikova
L N
LN
Lebedeva
T M
TM
Mel'nikov
N A
NA
Gusmanova
A G
AG
Deviatkov
M Iu
MIu
Rozanova
E V
EV
Mukachev
M A
MA
D000293:Adolescent; D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000097:blood; D001317:Austria; D002648:Child; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D006801:Humans; D007114:Immunization / Q000379:methods* / Q000706:statistics & numerical data; D007117:Immunization, Secondary / Q000379:methods / Q000706:statistics & numerical data; D012426:Russia; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
Izuchenie kul'tural'noĭ kontsentrirovannoĭ inaktivirovannoĭ vaktsiny protiv kleshchevogo éntsefalita pri immunizatsii deteĭ i podrostkov.