Increase in O(2) delivery with hyperoxia does not increase O(2) uptake in tetanically contracting dog muscle.
We investigated the influence of hyperoxia on O(2) uptake in tetanically contracting canine gastrocnemius. Hyperoxia showed neither increase in O(2) uptake nor decrease in lactate release, irrespective of increased O(2) supply, venous Po(2) and vascular resistance, as compared to normoxia, suggesting that hyperoxia decreases O(2) diffusion conductance and/or effective O(2) supply probably due to arteriovenous O(2) diffusion shunt.
Kohzuki
H
H
Department of Physiology II, Nara Medical University, Kashihara, 634-8521 Japan. hkohzuki@naramed-u.ac.jp
Sakata
S
S
Ohga
Y
Y
Misawa
H
H
Kishi
T
T
Takaki
M
M
D015308:Anaerobic Threshold / Q000502:physiology; D000818:Animals; D001160:Arterioles / Q000502:physiology; D004058:Diffusion; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism; D018496:Hyperoxia / Q000503:physiopathology*; D007773:Lactates / Q000378:metabolism; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology
D007773:Lactates; D010100:Oxygen