title: Clinical management of avulsed permanent incisors using Emdogain: initial report of an investigation.
abstract: The enamel matrix derivative Emdogain was recently approved for clinical use in a number of countries, including Canada. It has been shown to stimulate regeneration of periodontal ligament following periodontal surgery in adults. This paper reviews pertinent clinical and laboratory studies of Emdogain and describes the protocol and methods used for a longitudinal outcome study of replantation of avulsed permanent incisors in children and adolescents. Application of these methods is described in an illustrative case report of Emdogain use. This paper is meant to inform clinicians and guide those who are instituting similar investigations.
authors.affiliation: Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: D J
authors.initials: DJ
authors.lastname: Kenny
authors.forename: E J
authors.initials: EJ
authors.lastname: Barrett
authors.forename: D H
authors.initials: DH
authors.lastname: Johnston
authors.forename: M J
authors.initials: MJ
authors.lastname: Sigal
authors.forename: H C
authors.initials: HC
authors.lastname: Tenenbaum
mesh_terms: D000293:Adolescent; D002648:Child; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D006801:Humans; D007180:Incisor / Q000601:surgery*; D008297:Male; D010513:Periodontal Ligament / Q000502:physiology; D012038:Regeneration; D014084:Tooth Avulsion / Q000503:physiopathology / Q000601:surgery*; D014090:Tooth Replantation; D014945:Wound Healing / Q000502:physiology
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins