title: [Primary pulmonary cryptococcosis with endobronchial lesion].
abstract: A 19-year old man was admitted to our hospital with fever and productive cough. Chest X-ray films revealed multiple nodular shadows accompanied by a fusing tendency in the right middle field. A diagnosis of bacterial pneumonia was indicated, and the patient was treated with antibiotics. However, because this failed to resolve the nodular shadows, bronchofibroscopy was performed. Examination with a fiberoptic bronchoscope revealed an elevated lesion in the truncus intermedius. Histopathologic examination of a specimen obtained by transbronchial biopsy revealed cryptococcal organisms with the infiltration of monocytes. These findings yielded a diagnosis of pulmonary cryptococcosis with endobronchial lesion. After 6 months of treatment with fluconazole, the multiple nodular shadows disappeared. Comparison of bronchoscopic findings before and after fluconazole treatment clearly demonstrated the efficacy of the therapy.
authors.affiliation: Second Department of Internal Medicine, Oita Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mito
authors.forename: H
authors.initials: H
authors.lastname: Kawano
authors.forename: Y
authors.initials: Y
authors.lastname: Yamakami
authors.forename: K
authors.initials: K
authors.lastname: Arita
authors.forename: Y
authors.initials: Y
authors.lastname: Uenishi
authors.forename: H
authors.initials: H
authors.lastname: Nagaoka
authors.forename: H
authors.initials: H
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Nasu
mesh_terms: D000328:Adult; D000946:Antigens, Fungal / Q000097:blood; D001980:Bronchi / Q000382:microbiology / Q000473:pathology*; D003453:Cryptococcosis / Q000382:microbiology / Q000473:pathology*; D003455:Cryptococcus neoformans / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D008172:Lung Diseases, Fungal / Q000382:microbiology / Q000473:pathology*; D008297:Male
chemical_list: D000946:Antigens, Fungal