Cationic chlorophyl derivatives with SOD mimicking activity suppress the proliferation of human ovarian cancer cells.
Derivatives of chlorophyl, e.g. Fe-chlorin e6-Na, alpha, beta, gamma, delta-Tetraphenylporphine-tetrasulfonic acid disulfonic acid salt tetrahydrate (Fe-TPPTS) and alpha, beta, gamma, delta-Tetrakis (4-N-trimethylaminophenyl) porphine, tetra (p-toluensulfonate (Fe-TTMAPP), express SOD mimicking activity. Examination was made of suppressive effects of human cancer cell lines by derivatives of chlorophyl. Fe-TPPTS and Fe-TTMAPP suppressed proliferation of the human ovarian cancer cell lines but Fe-chlorin e6-Na failed to suppress the proliferation. Lipid peroxide was increased by application of Fe-TPPTS and Fe-TTMAPP, but decreased by application of Fe-chlorin e6-Na. SOD activity of the cancer cells did not change by application of these drugs. TPPTS and TTMAPP have a cationic charge but Fe-chlorin e6-Na has an anionic charge. It is suggested that charge of these drugs relates to the suppressive effects of the cancer cell proliferation.
Kobayashi
Y
Y
Molecular Biology Laboratory, Kitasato University School of Medicine, Kanagawa, Japan.
Maniki
M
M
Nakamura
K
K
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002734:Chlorophyll / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D013482:Superoxide Dismutase / Q000494:pharmacology*
D000970:Antineoplastic Agents; D008054:Lipid Peroxides; D002734:Chlorophyll; D013482:Superoxide Dismutase