[Cutaneous, hepatic and hematologic manifestations due to nevirapine: DRESS syndrome?].
BACKGROUND
Manifestations similar to DRESS syndrome (drug rash with eosinophilia and systemic symptoms) may be induced by nevirapine.


METHODS
Three patients developed skin rash and general signs of liver dysfunction during the first 5 weeks after starting nevirapine. Laboratory tests showed elevated eosinophil counts and signs of inflammation simulating severe infection.


CONCLUSIONS
The incidence of DRESS syndrome is probably underestimated. No standard treatment has been proposed. In our 3 patients, parenteral corticosteroid therapy was successful, leading to a rapidly favorable clinical course although liver tests took longer to return to normal.
Sissoko
D
D
Service Régional Universitaire des Maladies infectieuses et du Voyageur, Tourcoing.
Ajana
F
F
de la Tribonnière
X
X
Baclet
V
V
Mouton
Y
Y
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001247:Asthenia / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury; D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007964:Leukocytosis / Q000139:chemically induced*; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D019829:Nevirapine / Q000009:adverse effects*; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects*; D013577:Syndrome
D019380:Anti-HIV Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine; D008775:Methylprednisolone
Manifestations cutanées, hépatiques et hématologiques liées à la névirapine: DRESS syndrome?