Beta-sheet modeling by helical surfaces.
We present a topological description of a beta-sheet in terms of a piece of helical surface. It requires only two easy-to-handle parameters: the twist, i.e. the turn of the helical surface per residue, and the coiling, which is a curvature along the strands or in the direction perpendicular to the strands of the sheet. This method applies fairly well to three- and four-strand sheets, forming a too limited structure to be able to build a barrel. From an analysis of beta-sheets derived from a structural database, we show that this picture can even be reduced to the use of one main value, the twist angle. The dependence of beta-sheet twisting on the number of strands in a sheet, and also on the length and direction of strands, has been demonstrated. The applications of such a description may include the rapid modeling of 3D structures.
Znamenskiy
D
D
Equipe Systèmes Moléculaires et Biologie Structurale, LMCP, CNRS UMR7590, Universités Paris 6 et Paris 7, Case 115, 75252 Paris cedex 05, France.
Le Tuan
K
K
Poupon
A
A
Chomilier
J
J
Mornon
J P
JP
D019295:Computational Biology / Q000379:methods; D003198:Computer Simulation; D016208:Databases, Factual; D008956:Models, Chemical; D011237:Predictive Value of Tests; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000145:classification
D011506:Proteins