Clinical significance of the DNA index in hematogenous dissemination of aneuploid colorectal cancer.
The DNA index (DI), defined as the ratio of the G0/G1 channel number of tumor cells to the G0/G1 channel number of stromal cells, was analyzed in 121 aneuploid colorectal cancers. In patients with aneuploid tumors, a high DI significantly correlated with tumor penetration beyond the proper muscle layer, positive vascular invasion, and the presence of liver metastasis. This observation led us to conclude that a high DI is likely to be associated with hematogenous dissemination in aneuploid colorectal cancer.
Yamamoto
T
T
Second Department of Surgery, Mie University School of Medicine, Tsu, Japan.
Matsumoto
K
K
Yamamoto
J
J
Kitagawa
T
T
Miki
C
C
Iriyama
K
K
Suzuki
H
H
D000782:Aneuploidy; D003106:Colon / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology*; D016193:G1 Phase / Q000502:physiology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D012007:Rectum / Q000473:pathology; D016192:Resting Phase, Cell Cycle / Q000502:physiology