Neonatal lupus erythematosus.
Neonatal lupus erythematosus (NLE) is a rare disease characterized by the transplacental passage from the mother to the fetus of autoantibodies, in particular anti-Ro(SS-A), anti-La(SS-B), or both. The majority of infants with NLE exhibit isolated congenital heart block, cutaneous lesions analogous to those of adult subacute cutaneous lupus erythematosus, or both. We report a case of NLE in a 3-month-old male infant, born to a clinically asymptomatic mother, presenting small, annular, erythematous plaques with sharp, hyperkeratotic borders and central clearing localized at the eyebrow region. Both the infant and the mother were positive for anti-Ro(SS-A).
Corona
R
R
Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy.
Angelo
C
C
Cacciaguerra
M G
MG
Conti
G
G
De Pità
O
O
Coletti
V
V
el Hachem
M
M
Paradisi
M
M
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis
D001323:Autoantibodies