title: (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.
abstract: A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.
authors.affiliation: Nervous System Research, Novartis Pharma AG, Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com
authors.forename: F
authors.initials: F
authors.lastname: Gasparini
authors.forename: W
authors.initials: W
authors.lastname: Inderbitzin
authors.forename: E
authors.initials: E
authors.lastname: Francotte
authors.forename: G
authors.initials: G
authors.lastname: Lecis
authors.forename: P
authors.initials: P
authors.lastname: Richert
authors.forename: Z
authors.initials: Z
authors.lastname: Dragic
authors.forename: R
authors.initials: R
authors.lastname: Kuhn
authors.forename: P J
authors.initials: PJ
authors.lastname: Flor
mesh_terms: D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
chemical_list: C119327:4-phosphonophenylglycine; D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; D005998:Glycine