Multifactorial thrombotic-type microangiopathy with skin ulcers and hepatitis C infection.
The case of a patient with hepatitis C virus infection who presented with symmetric ulcers of the legs is reported. She was found to have type III mixed cryoglobulinemia, high titers of anticardiolipin antibodies, lupus anticoagulant, and a free protein S deficiency. To our knowledge, this is the first reported case of such an association. The role of these factors in the pathogenesis of skin lesions in the setting of hepatitis C virus infection is discussed.
Hernández
JL
Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, 39008, Santander, Spain
Zarrabeitia
R
Fernández-Llaca
H
Hortal
L
González-Macías
J