title: Microscopic polyangiitis that presented liver dysfunction prior to noted renal manifestations.
abstract: In microscopic polyangiitis (MPA), renal manifestations are very common as first symptoms. Here, we report a case of MPA which presented liver dysfunction prior to noted renal manifestations. A 58-year-old woman was hospitalized because of a fever for 8 weeks. A laboratory examination revealed marked elevation of alkaline phosphatase and gamma-glutamyl transpeptidase, while blood urea nitrogen and creatinine levels remained normal. Although apparent renal dysfunction developed in this case soon after hospitalization, physicians should be aware of the variety of clinical manifestations in MPA. Moreover, antineutrophil cytoplasmic autoantibodies were found to be helpful for diagnosing MPA.
authors.affiliation: Department of Internal Medicine, Takanohara General Hospital, Nara.
authors.forename: T
authors.initials: T
authors.lastname: Nakamoto
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: Y
authors.initials: Y
authors.lastname: Yamane
authors.forename: S
authors.initials: S
authors.lastname: Iwasawa
authors.forename: M
authors.initials: M
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Kawanami
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Fukui
mesh_terms: D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology*; D008107:Liver Diseases / Q000209:etiology*; D008875:Middle Aged; D014657:Vasculitis / Q000150:complications* / Q000175:diagnosis*