title: [Tourette's syndrome and antidepressant therapy: exacerbation of nervous tics with paroxetine].
abstract: One possible side effect of selective serotonin re-uptake inhibitors (SSRI) is the exacerbation of nervous tics in a 12-year-old boy treated with tiapride following prescription of paroxetine for a depressive syndrome. Potential causal factors include residual cholinergic activity of paroxetine, the observably increased drive under paroxetine, metabolic properties, and protein binding. The problem of side effects under selective serotonin re-uptake inhibitors, as well as the issues of co-morbidity and co-medication in the treatment of nervous tics and Tourette's Syndrome are discussed.
authors.affiliation: Heckscher-Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters des Bezirks Oberbayern, München.
authors.forename: U
authors.initials: U
authors.lastname: Rüth
authors.forename: J
authors.initials: J
authors.lastname: Mayer-Rosa
authors.forename: D
authors.initials: D
authors.lastname: Schlamp
authors.forename: F J
authors.initials: FJ
authors.lastname: Freisleder
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D003863:Depression / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D016666:Fluvoxamine / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D017374:Paroxetine / Q000008:administration & dosage / Q000009:adverse effects*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D020323:Tics / Q000139:chemically induced* / Q000209:etiology; D005879:Tourette Syndrome / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome; D014299:Trimipramine / Q000627:therapeutic use
chemical_list: D000929:Antidepressive Agents, Tricyclic; D016666:Fluvoxamine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors; D014299:Trimipramine
vernacular_title: Tourette-Syndrom und Antidepressiva-Therapie: Exazerbation einer Ticstörung unter Paroxetin.