title: Orthopedic emergencies in cancer patients.
abstract: The most frequent orthopedic emergency in oncology patients is fracture. Stabilization of the entire fractured bone restores function and relieves pain. The site, quality, and extent of the lesion can identify impending fractures that should be stabilized. New methods of pelvic stabilization effectively bypass periacetabular bone deficiency. Spinal cord decompression is important to maintain neurologic function. Advances in segmental fixation of the spine have improved the outcome over what was achieved by radiation alone. Infection is common in neutropenic patients, and should be treated aggressively with antibiotics and drainage of abscesses of the musculoskeletal system. Extravasation of doxorubicin requires prompt local debridement to limit the extent of necrosis propagation. These treatments can effectively improve the quality of life of patients with metastatic cancer. They should be included as "best supportive care" for patients with more than 1 month to live.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: H H
authors.initials: HH
authors.lastname: Manglani
authors.forename: R A
authors.initials: RA
authors.lastname: Marco
authors.forename: A
authors.initials: A
authors.lastname: Picciolo
authors.forename: J H
authors.initials: JH
authors.lastname: Healey
mesh_terms: D000038:Abscess / Q000209:etiology / Q000473:pathology; D000671:Amputation, Surgical; D000970:Antineoplastic Agents / Q000009:adverse effects; D001170:Arthritis, Infectious / Q000209:etiology / Q000473:pathology; D001847:Bone Diseases / Q000209:etiology / Q000473:pathology; D004317:Doxorubicin / Q000009:adverse effects; D004630:Emergencies; D005598:Fractures, Spontaneous / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology / Q000473:pathology; D009369:Neoplasms / Q000150:complications*; D013117:Spinal Cord Compression / Q000209:etiology* / Q000473:pathology / Q000628:therapy
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin