Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants.
Through a literature search, we identified a total of 59 nuclear families with Hodgkin's disease (HD). The affected individuals in these families were HLA haplotyped. To evaluate the role of HLA-linked determinants of HD and investigate the mode of inheritance of familial HD, a combined segregation and linkage analysis was performed, together with a semi-parametric analysis of sib pairs. Amongst single locus models, a general single locus model showed no improvement over an additive model. However, a two locus additive model gave the best overall fit and a lod score of 3.55. We conclude that HD is most likely to be determined by both an HLA-associated major gene and other non-HLA genetic factors together with environmental effects.
Shugart
Y Y
YY
Center for Inherited Disease Research, Department of Pediatrics, Johns Hopkins University, Baltimore, MD 21224, USA. yyao@cidr.jhmi.edu
Collins
A
A
D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006689:Hodgkin Disease / Q000235:genetics*; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D009679:Nuclear Family
D006680:HLA Antigens