title: Cushing's syndrome associated with a chemodectoma and a carcinoid tumour.
abstract: We present a case of Cushing's syndrome where 111In-octreotide scanning provided evidence for the presence of two neuroendocrine tumours. Uptake in the right neck corresponded to a chemodectoma, but there was no change in the clinical condition or fall in ACTH levels following surgical resection. Uptake in the left chest was assumed to relate to a bronchial carcinoid, but a tumour could not initially be localized on magnetic resonance imaging (MRI), spiral CT scanning or on selective venous sampling. A 1 cm bronchial carcinoid tumour was identified post-mortem which immunostained for ACTH. This case demonstrates that 111ln-octreotide scanning is a useful technique for identifying the source of ectopic ACTH production in difficult cases of Cushing's syndrome. Reliance should not be placed solely on standard imaging techniques to localize the tumour prior to surgery. Although rare, the possibility of a non-ACTH secreting neuroendocrine tumour should also be considered in patients with ectopic ACTH syndrome, who have positive 111In-octreotide scans.
authors.affiliation: Department of Medicine, King's College Hospital, London, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Tremble
authors.forename: M
authors.initials: M
authors.lastname: Buxton-Thomas
authors.forename: D
authors.initials: D
authors.lastname: Hopkins
authors.forename: P
authors.initials: P
authors.lastname: Kane
authors.forename: D
authors.initials: D
authors.lastname: Bailey
authors.forename: P E
authors.initials: PE
authors.lastname: Harris
mesh_terms: D000328:Adult; D015901:Angiography, Digital Subtraction; D001984:Bronchial Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002276:Carcinoid Tumor / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D002339:Carotid Arteries; D003480:Cushing Syndrome / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D015282:Octreotide; D010236:Paraganglioma, Extra-Adrenal / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes; D015282:Octreotide