The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292.
The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the structures of a peptide based CCK1 receptor selective agonist and a peptoid CCK2 receptor selective antagonist.
Bernad
N
N
CCIPE-Faculte de Pharmacie, Montpellier, France.
Burgaud
B G
BG
Horwell
D C
DC
Lewthwaite
R A
RA
Martinez
J
J
Pritchard
M C
MC
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002956:Citrulline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D034444:Peptoids; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000819:agonists*
C414945:PD 170292; D034444:Peptoids; D011949:Receptors, Cholecystokinin; D002956:Citrulline; D000218:Adamantane