title: Hereditary pancreatitis. Historical perspectives.
abstract: Clinically, hereditary pancreatitis was not distinguishable from any other cause of pancreatitis. But astute clinical observations demonstrated an evolution toward chronic pancreatitis that could develop into carcinoma in some patients. A chromosomal abnormality was identified on chromosome 7q35, and then three separate genetic abnormalities were identified. It is now understood that a defect in trypsinogen is at the basis of the anomaly, and further developments should help identify new therapeutic approaches.
authors.affiliation: Department of Pediatrics, Mayo Medical School, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
authors.forename: J
authors.initials: J
authors.lastname: Perrault
mesh_terms: D002869:Chromosome Aberrations / Q000266:history*; D025063:Chromosome Disorders; D002897:Chromosomes, Human, Pair 7; D002908:Chronic Disease; D030342:Genetic Diseases, Inborn / Q000266:history*; D049673:History, 20th Century; D006801:Humans; D010195:Pancreatitis / Q000235:genetics / Q000266:history*