title: Understanding the insertion of transporters and other membrane proteins.
abstract: Recent studies show that transporters integrate into the lipid bilayer using topogenic sequences present throughout the entire polypeptide chain. These topogenic sequences can act in unpredictable ways with new translocation/stop transfer activities. In addition, a new membrane-insertion pathway has been identified in bacteria with homologs in mitochondria and chloroplasts.
authors.affiliation: Department of Chemistry, Ohio State University, Columbus, 43210, USA. dalbey@chemistry.ohio-state.edu.
authors.forename: R E
authors.initials: RE
authors.lastname: Dalbey
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: F
authors.initials: F
authors.lastname: Jiang
authors.forename: J C
authors.initials: JC
authors.lastname: Samuelson
mesh_terms: D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins