[In vitro study of of the effects of cysteinyl leukotrienes on human vascular preparations].
Leukotrienes are 5-lipoxygenase-derived arachidonic acid metabolites. In addition to their bronchoconstrictor effects, leukotrienes are also important modulators of the vascular tone which may exert paradoxical effects. Indeed, depending on the vascular tone (in either the basal or norepinephrine-precontracted state), leukotrienes are capable of inducing either contraction or relaxation. These paradoxical effects of leukotrienes depend on the vascular bed and the species investigated. Since urinary LTE4 excretion is increased in various cardiovascular diseases, including arterial pulmonary hypertension or cardiac ischaemia, the study of the effects of leukotrienes on human vascular preparations is of interest. This article reviews the in vitro evidence linking cysteinyl leukotrienes to the modulation of the vascular tone on human vascular preparations.
Stanke-Labesque
F
F
Laboratoire de Pharmacologie, PCEBM, Faculté de Médecine, La Tronche, France.
Cracowski
J L
JL
Devillier
P
P
Bessard
G
G
D001808:Blood Vessels / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D017998:Leukotriene D4 / Q000096:biosynthesis / Q000494:pharmacology; D017999:Leukotriene E4 / Q000096:biosynthesis / Q000494:pharmacology; D015289:Leukotrienes / Q000096:biosynthesis / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*
D015289:Leukotrienes; D017998:Leukotriene D4; D017999:Leukotriene E4
Etude in vitro des effets des cystéinyl leucotriènes sur des préparations vasculaires d'origine humaine.