[Prenatal diagnosis of conotruncal heart diseases. Results in 337 cases].
Prenatal diagnosis of conotroncal disease has developed by examination of the great arteries during morphological foetal ultrasonic scanning in the second term of pregnancy. This study reports the results of a series of 337 of these malformations diagnosed in the foetus over five and a half years. Their incidence with respect to all foetal cardiac malformations is 16.2%. Tetralogy of Fallot and pulmonary atresia with ventricular septal defect make up 56% of these cases, vascular malposition 16%, coarctation with or without interruption of the aortic arch 14%, truncus arteriosus 9% and agenesis of the pulmonary valves 5%. A karyotypic anomaly was found in 28 cases (8.2%) and, in the foetus with a normal standard karyotype, deletion of chromosome 22q11 was identified in 54 out of 237 cases. There was an associated polymalformative syndrome in 29 cases (8.3%). The training of obstetricians has increased the number of antenatal diagnoses of conotroncal abnormalities. Prenatal counselling should be given by a pluridisciplinary team because the association of these malformations with chromosomal abnormalities or with syndromes difficult to diagnose is common.
Boudjemline
Y
Y
Service de cardiologie pédiatrique, hôpital Necker-Enfants-malades, Paris.
Fermont
L
L
Le Bidois
J
J
Fraisse
A
A
Kachaner
J
J
Villain
E
E
Sidi
D
D
Bonnet
D
D
D018376:Cardiovascular Abnormalities / Q000000981:diagnostic imaging* / Q000196:embryology* / Q000235:genetics; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000196:embryology* / Q000235:genetics; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000196:embryology; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D018633:Pulmonary Atresia / Q000150:complications / Q000000981:diagnostic imaging / Q000196:embryology; D013771:Tetralogy of Fallot / Q000000981:diagnostic imaging / Q000196:embryology; D016216:Ultrasonography, Prenatal
Diagnostic prénatal des cardiopathies conotroncales. A propos de 337 cas.