Sucrose and quinine intake by maternally-deprived and control rhesus monkeys.
Clinical depression is often characterized by a loss of interest or pleasure in formerly enjoyable activities. Analogs of anhedonia are established in rats, but the generality of this phenomenon to other species is unknown. Maternally-deprived rhesus macaques show a wide range of behavioral abnormalities that are reversed by chronic antidepressant treatment. We tested consumption by maternally deprived versus control macaques of sweetened (seven sucrose concentrations) or bitter water (four quinine concentrations) versus plain water to evaluate a non-human primate model of depression for signs of anhedonia. All monkeys consumed more sweetened than tap water, but maternally-deprived monkeys had a diminished preference for sweetened water than did controls. However, maternally deprived animals consumed more bitter water than did controls. Baseline fluid consumption did not differ. The data suggest that 'anhedonia' in animal models may be secondary to a generally attenuated responsiveness to stimuli, rather than a unitary reduction in responsiveness to the appetitive properties of stimuli. We conclude that maternally-deprived rhesus monkeys do not display gustatory signs of anhedonia, but rather of insensitivity to gustatory stimuli.
Paul
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Department of Psychiatry, Division of Neurobiology and Behavior Research, Laboratory of Neurobehavioral Pharmacology and Immunology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA. ipaul@psychiatry.umsmed.edS
English
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Halaris
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D000818:Animals; D001070:Appetitive Behavior; D003863:Depression / Q000209:etiology / Q000523:psychology*; D004195:Disease Models, Animal; D005518:Food Preferences / Q000523:psychology*; D008253:Macaca mulatta; D008426:Maternal Deprivation; D011803:Quinine / Q000008:administration & dosage*; D012646:Self Administration; D013395:Sucrose / Q000008:administration & dosage*; D013649:Taste
D013395:Sucrose; D011803:Quinine