title: Comparison between critical pathway guidelines and management of deep-vein thrombosis: retrospective cohort study.
abstract: OBJECTIVE
  To compare the key steps of standard deep-vein thrombosis management with the critical pathway practice guidelines, and to assess the outcome of the treatment after 6 months.
  
  
  METHODS
  This retrospective cohort study (from January 1, 1997 to December 31, 1998) included 172 patients with uncomplicated deep-vein thrombosis of lower extremities, consecutively admitted via emergency room. The data were collected from the entry register in emergency room and medical charts. The outcome of therapy was assessed 6 months after the acute event.
  
  
  RESULTS
  A bolus dose of heparin was administered to 81 (46%) patients. The recommended initial heparin infusion rate at 1250 U/h was employed in only 26 (15%) patients. Time to activated partial thromboplastin time >60 s was met in 29 (17%) patients. All patients but one received heparin therapy longer than 96 h. The recommended time to a therapeutic international normalized ratio of less than 120 h was achieved in 134 (78%) patients, but the average length of a stay in the hospital exceeded the recommended 5. 5 days by 86%. Six months later, compressive ultrasonography revealed 44 (28.9%) cases of complete vein obstruction, 67 (44.1%) cases of partial recanalization and 41 (27%) cases with a normal finding. Recurrent thrombosis developed in 16 patients (10.5%) and acute pulmonary embolism in 4 (2.6%) patients.
  
  
  CONCLUSIONS
  Our results considerably differ from the critical pathway guidelines due to the lower initial heparin doses and longer diagnostic assessment of thrombosis etiology. Our approach to deep-vein thrombosis treatment was a combination of the critical pathway guidelines and the conventional regimen. The clinical outcome in our series did not differ significantly from the outcome after the conventional way of treatment.
authors.affiliation: Department of Medicine, Holy Ghost General Hospital, Zagreb, Croatia, nvucic@public.srce.hr
authors.forename: N
authors.initials: N
authors.lastname: Vucić
authors.forename: N
authors.initials: N
authors.lastname: Lang
authors.forename: S
authors.initials: S
authors.lastname: Balić
authors.forename: V
authors.initials: V
authors.lastname: Pilas
authors.forename: T
authors.initials: T
authors.lastname: Anić
authors.forename: V
authors.initials: V
authors.lastname: Nadinić
authors.forename: O
authors.initials: O
authors.lastname: Brborovic
mesh_terms: D015331:Cohort Studies; D019091:Critical Pathways; D005260:Female; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D012189:Retrospective Studies; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000628:therapy*
chemical_list: D006493:Heparin