Involvement of nitric oxide from nerves on diarrhea induced by castor oil in rats.
Nitric oxide (NO) is involved in the mechanism of castor oil-induced diarrhea. This study was performed to elucidate the source of NO. Diarrhea was induced by oral administration of castor oil in rats. Diarrhea was significantly inhibited by the pre-treatment with a relatively selective nerve NO synthase inhibitor, 7-nitroindazole. This effect was attenuated by the treatment with L-arginine. Capsaicin-sensitive afferent nerve degeneration did not affect the diarrhea. N(G)-Nitro-L-arginine methylester significantly inhibited diarrhea even in capsaicin-pretreated rats. These data suggest, at least in part, the involvement of NO from nerves on the diarrhea induced by castor oil in rats.
Uchida
M
M
Meiji Institute of Health Science, Odawara, Kanagawa, Japan.
Kato
Y
Y
Matsueda
K
K
Shoda
R
R
Muraoka
A
A
Yamato
S
S
D000818:Animals; D002368:Castor Oil / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009569:Nitric Oxide; D002368:Castor Oil; D019331:NG-Nitroarginine Methyl Ester