title: SAR studies of 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones as inhibitors of 4-hydroxyphenylpyruvate dioxygenase.
abstract: Inhibition studies of 4-hydroxyphenylpyruvate dioxygenase (HPPD) with various synthesized 2-o-substituted-benzoyl- and 2-alkanoyl-cyclohexane-1,3-diones suggest that the presence of a strongly electronegative group at the ortho position and the conformation of the benzene ring moiety on the benzoylcyclohexane-1,3-dione inhibitors are crucial for potent HPPD inhibition.
authors.affiliation: Department of Chemistry, Tunghai Christian University, Taichung, Taiwan, ROC.
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
authors.forename: C S
authors.initials: CS
authors.lastname: Wu
authors.forename: S W
authors.initials: SW
authors.lastname: Lin
authors.forename: D Y
authors.initials: DY
authors.lastname: Yang
mesh_terms: D015111:4-Hydroxyphenylpyruvate Dioxygenase / Q000037:antagonists & inhibitors*; D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002384:Catalysis; D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology; D013329:Structure-Activity Relationship; D013552:Swine
chemical_list: D000473:Alkanes; D003510:Cyclohexanes; D004791:Enzyme Inhibitors; D007659:Ketones; D015111:4-Hydroxyphenylpyruvate Dioxygenase