Inhibition of neuraminidase with neuraminic acid C-glycosides.
Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15-30 microM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.
Wang
Q
Q
Department of Chemistry, Medicinal and Natural Products Chemistry and Chemical and Biochemical Engineering, The University of Iowa, Iowa City 52242, USA.
Wolff
M
M
Polat
T
T
Du
Y
Y
Linhardt
R J
RJ
D002021:Buffers; D003016:Clostridium perfringens / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D009438:Neuraminic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D002021:Buffers; D004791:Enzyme Inhibitors; D006027:Glycosides; D009438:Neuraminic Acids; D009439:Neuraminidase