title: Environmental radon daughters reveal pathognomonic changes in the brain proteins and lipids in patients with Alzheimer's disease and Parkinson's disease, and cigarette smokers.
abstract: This paper presents an investigation of the retention of environmental radon daughters, 210Po (alpha particle emitting radio-nuclide) and 210Bi (beta particle emitting radio-nuclide), in lipid and protein fractions of the cortical grey and subcortical white matter from the frontal and temporal brain lobes of patients who had suffered from Alzheimer's disease or Parkinson's disease, of cigarette smokers, and of control subjects. 210Po and 210Bi radioactivity increased tenfold in the cortical grey and subcortical white protein fraction in patients with Alzheimer's disease and smokers, and tenfold in the cortical grey and subcortical white lipid fraction in patients with Parkinson's disease. Free radicals generated by radon daughters may add to the severity of the radio-chemical injury to the brain astrocytes. The pathognomonic distribution of radon daughters to lipids in patients with Parkinson's disease and to proteins in patients with Alzheimer's disease was attributed to high chlorine affinity of radon daughters. The changes in the membrane protein pores, channels, and gates in patients with Alzheimer's disease and in the lipid bilayer in patients with Parkinson's disease are at the core of what the authors think are two systemic brain diseases.
authors.affiliation: Institute for Medical Research and Occupational Health, Zagreb, Croatia. momcilovic@imi.hr
authors.forename: B
authors.initials: B
authors.lastname: Momcilović
authors.forename: H A
authors.initials: HA
authors.lastname: Alkhatib
authors.forename: J A
authors.initials: JA
authors.lastname: Duerre
authors.forename: M A
authors.initials: MA
authors.lastname: Cooley
authors.forename: W M
authors.initials: WM
authors.lastname: Long
authors.forename: R T
authors.initials: RT
authors.lastname: Harris
authors.forename: G I
authors.initials: GI
authors.lastname: Lykken
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000378:metabolism* / Q000528:radiation effects; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism* / Q000528:radiation effects; D010300:Parkinson Disease / Q000378:metabolism*; D017687:Radon Daughters / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism*
chemical_list: D008055:Lipids; D009419:Nerve Tissue Proteins; D017687:Radon Daughters