title: [IgG and IgA immunoglobulins in helicobacter pylori infections of children with chronic dyspepsia before and after two week triple drug therapy].
abstract: The aim of this study was to investigate whether serological techniques, ELISA and Western blot, are useful in monitoring treatment of H. pylori-associated chronic dyspeptic symptoms in children. We observed a correlation between a decrease in the anti-H. pylori IgG titer and an effective treatment. So, our results suggested that the ELISA assay conducted with a glycine H. pylori extract can be a good noninvasive assay for monitoring the effectiveness of the therapy. By using the Western blot method, we showed some variation in the specificity of anti-H. pylori IgG produced before and after treatment. However, this variation was not correlated with the effectiveness of the therapy.
authors.affiliation: Zakład Biologii Infekcyjnej, Instytut Mikrobiologii i Immunologii, Uniwersytet Lódzki.
authors.forename: M
authors.initials: M
authors.lastname: Lawnik
authors.forename: E
authors.initials: E
authors.lastname: Czkwianianc
authors.forename: M
authors.initials: M
authors.lastname: Chmiela
authors.forename: I
authors.initials: I
authors.lastname: Płaneta-Małecka
authors.forename: W
authors.initials: W
authors.lastname: Rudnicka
mesh_terms: D000293:Adolescent; D000658:Amoxicillin / Q000008:administration & dosage; D001729:Bismuth / Q000008:administration & dosage; D015153:Blotting, Western; D002648:Child; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004415:Dyspepsia / Q000175:diagnosis* / Q000188:drug therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage; D008991:Monitoring, Physiologic / Q000379:methods; D011899:Ranitidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D012698:Serologic Tests / Q000379:methods*
chemical_list: D008795:Metronidazole; C073340:ranitidine bismuth citrate; D000658:Amoxicillin; D011899:Ranitidine; D001729:Bismuth
vernacular_title: Immunoglobuliny IgG i IgA w zakazeniach Helicobacter pylori dzieci z przewlekła dyspepsja przed i po dwutygodniowej trójlekowej terapii.