[Percutaneous intrahepatic portosystemic shunting in the treatment of veno-occlusive disease of the liver after bone marrow transplantation].
Veno-occlusive disease of the liver is a frequent cause of morbidity and mortality after bone-marrow transplantation. Its clinical manifestations are primarily related to the development of portal hypertension and sinusoidal congestion. The efficacy of the different therapeutic options used is controversial. We present a 22-year-old woman with veno-occlusive liver disease histologically confirmed after autologous bone-marrow transplantation, with progressive alteration in liver biochemistry and ascites. She was treated by percutaneous intrahepatic portosystemic shunting. After the procedure there was a marked improvement in ascites and an increase in diuresis with liver function progressively returning to normal. The safety and efficacy of this approach in the treatment of patients with veno-occlusive liver disease should be evaluated in controlled studies.
Alvarez
R
R
Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón, Madrid.
Bañares
R
R
Casariego
J
J
Echenagusía
A
A
Simó
G
G
Alvarez
E
E
Serrano
D
D
Díez-Martín
J L
JL
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000209:etiology / Q000628:therapy*; D006801:Humans; D011170:Portasystemic Shunt, Surgical
Tratamiento de la enfermedad venooclusiva hepática tras trasplante de médula ósea mediante derivación portosistémica percutánea intrahepática.