Development. PARallels in axis formation.
There is an intricate network of molecules called cell fate determinants that instruct the cells of the embryo to take on either an anterior or posterior fate. In a lively Perspective, Lehmann and her colleagues discuss new findings in the fruit fly that identify a key protein, PAR-1, which ensures that the cell fate determinants are themselves located in the correct region of the oocyte. In this way, the anterior-posterior axis is set up in the fruit fly egg before fertilization.
Morris
J
J
Developmental Genetics Program, Skirball Institute, Howard Hughes Medical Institute, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Lehmann
R
R
Navarro
C
C
D008841:Actin Cytoskeleton / Q000502:physiology; D000818:Animals; D019521:Body Patterning; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics / Q000502:physiology; D016764:Cell Polarity; D018385:Centrosome / Q000502:physiology; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D008870:Microtubules / Q000502:physiology; D009154:Mutation; D009865:Oocytes / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D019476:Insect Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D015534:Trans-Activators; C056478:bcd protein, Drosophila; C091675:osk protein, Drosophila; C069927:stau protein, Drosophila; D017346:Protein Serine-Threonine Kinases