title: A case of severe dysexecutive syndrome consecutive to chronic bilateral pallidal stimulation.
abstract: In treatment for severe Parkinson's disease (PD), a recent procedure was developed which consists of implanting electrodes in the internal Globus Pallidus (GPi) for chronic electrical stimulation. The consequences on cognitive function of such an intervention are quite variable. Although most group studies observed no significant post-operative change, individual cases of post-operative cognitive impairment were reported. The present study reports the case of a PD patient who underwent bilateral implantation of deep brain stimulation electrodes in the GPi and who, after surgery, suffered from a severe dysexecutive syndrome. An extensive neuropsychological examination showed a selective negative effect of pallidal stimulation on tests assessing executive function. When the stimulation was turned off, the impairment was partly reversible. This observation emphasizes the role of the GPi in executive function.
authors.affiliation: Neurologie A, CHRU de Lille, Hôpital Salengro, 59037 Lille, Cedex, France. kdujardin@nordnet.fr
authors.forename: K
authors.initials: K
authors.lastname: Dujardin
authors.forename: P
authors.initials: P
authors.lastname: Krystkowiak
authors.forename: L
authors.initials: L
authors.lastname: Defebvre
authors.forename: S
authors.initials: S
authors.lastname: Blond
authors.forename: A
authors.initials: A
authors.lastname: Destée
mesh_terms: D001288:Attention; D003071:Cognition; D004599:Electric Stimulation Therapy / Q000009:adverse effects*; D004567:Electrodes, Implanted; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008568:Memory; D008875:Middle Aged; D009415:Nerve Net; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology* / Q000601:surgery*; D011597:Psychomotor Performance