title: Non-infectious lung complications are closely associated with chronic graft-versus-host disease: a single center study of incidence, risk factors and outcome.
abstract: Non-infectious lung complications (NILC) are frequent, influencing morbidity and mortality of patients after allogeneic BMT. Although the term NILC encompasses a number of different entities, an association with GVHD has been noted for almost all of them. Our study was directed towards assessing the incidence and risk factors for developing NILC, as well as the response to treatment and long-term outcome. Forty (14.7%) out of 272 patients surviving for more than 3 months after allogeneic BMT, developed lung complications fulfilling the criteria for NILC. The evaluation was based on clinical investigation, radiologic imaging, lung function tests, broncho-alveolar lavage and biopsies. Risk factors were assessed by univariate and multiple statistical regression models, where chronic GVHD proved to be the only significant risk factor for the development of NILC (P = 0.011). In three patients NILC developed in direct association with donor lymphocyte infusions. The majority of patients responded well to treatment with corticosteroids and immunosuppressive drugs. NILC had no adverse effect on survival. The frequency of NILC was low in autologous (5%) as compared with allogeneic transplants (14.7%) but this difference was not statistically significant. Bone Marrow Transplantation (2000) 25, 1263-1268.
authors.affiliation: Department of Haematology/Oncology, University of Ulm, Ulm, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Duncker
authors.forename: D
authors.initials: D
authors.lastname: Dohr
authors.forename: S
authors.initials: S
authors.lastname: Harsdorf
authors.forename: J
authors.initials: J
authors.lastname: Duyster
authors.forename: M
authors.initials: M
authors.lastname: Stefanic
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: M
authors.initials: M
authors.lastname: Treiber
authors.forename: B
authors.initials: B
authors.lastname: Hertenstein
authors.forename: J
authors.initials: J
authors.lastname: Novotny
authors.forename: R
authors.initials: R
authors.lastname: Arnold
authors.forename: H
authors.initials: H
authors.lastname: Heimpel
authors.forename: L
authors.initials: L
authors.lastname: Bergmann
authors.forename: D
authors.initials: D
authors.lastname: Bunjes
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000209:etiology* / Q000503:physiopathology; D006402:Hematologic Diseases / Q000628:therapy*; D006801:Humans; D015994:Incidence; D008171:Lung Diseases / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014184:Transplantation, Homologous