title: [Pharmacological prophylaxis of gastroesophageal reflux. Incidence of pharyngocutaneous fistula after total laryngectomy].
abstract: Pharyngocutaneous fistula is a serious complication of total laryngectomy. This problem increases morbidity, prolongs hospitalization, and occasionally causes death. Numerous contributing factors have been implicated in fistula formation (1). We propose that gastroesophageal reflux, which often is subclinical, is an important trigger and should be prevented. We evaluated the effect of associating an antireflux agent like metoclopramide hydrochloride to our usual ranitidine of our protocol after total laryngectomy on reducing the incidence (p<0.05) of pharyngocutaneous fistula.
authors.affiliation: Servicio de ORL, Hospital Son Dureta, Palma de Mallorca, 07014, España.
authors.forename: P
authors.initials: P
authors.lastname: Sarría Echegaray
authors.forename: M
authors.initials: M
authors.lastname: Tomás Barberán
authors.forename: S
authors.initials: S
authors.lastname: Mas Mercant
authors.forename: R
authors.initials: R
authors.lastname: Soler Vilarrasa
authors.forename: A
authors.initials: A
authors.lastname: Romaguera Lliso
mesh_terms: D017577:Cutaneous Fistula / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D005260:Female; D005764:Gastroesophageal Reflux / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007825:Laryngectomy / Q000009:adverse effects*; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D010608:Pharyngeal Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D012189:Retrospective Studies
chemical_list: D018492:Dopamine Antagonists; D008787:Metoclopramide
vernacular_title: Profilaxis farmacológica del reflujo gastroesofágico. Incidencia de fístula faringocutánea tras laringuectomía total.