title: In vivo gallbladder bile diffusion coefficient measurement by diffusion-weighted echo planar imaging in hamster fed normal and lithogenic diets.
abstract: It is shown that in vivo measurement of bile water apparent diffusion coefficient (ADC) by diffusion-weighted echo-planar imaging (EPI) in hamster gallbladder is possible providing motion artifact-free ADC values. These ADC values are used to estimate bile viscosity variation induced by normal diets, cholesterol gallstone-inducing diets, and an antilithiasic drug, and to determine if a link exists between bile viscosity and cholesterol gallstone formation. Measurements were performed at 4.7 T with respiratory triggering in five groups of hamsters fed a commercial (RC) or a semisynthetic (SSD) diet, a SSD containing 0.2% hyodeoxycholic acid (SSD+HDC) and two lithogenic diets (LD5, LD10). ADC decreased significantly in LD10 (2.15+/-0.07x 10(-3) mm(2)s(-1)) and SSD+HDC (2.03+/-0.04) compared to RC (2.40+/-0.05) but not in the most lithogenic LD5 diet (2.33+/-0.06). No direct relationship was found between bile viscosity and gallstone incidence; however, viscosity seems to be related to lipid contents of diets. Magn Reson Med 43:854-859, 2000.
authors.affiliation: Unité INSERM 350, Institut Curie, Centre Universitaire, Orsay, France. bernard.tiffon@curie.u-psud.fr
authors.forename: B
authors.initials: B
authors.lastname: Tiffon
authors.forename: M
authors.initials: M
authors.lastname: Parquet
authors.forename: S
authors.initials: S
authors.lastname: Dubrac
authors.forename: C
authors.initials: C
authors.lastname: Lutton
authors.forename: A
authors.initials: A
authors.lastname: Volk
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002769:Cholelithiasis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000009:adverse effects; D006224:Cricetinae; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D017352:Echo-Planar Imaging / Q000379:methods*; D005704:Gallbladder / Q000378:metabolism*; D008297:Male; D012680:Sensitivity and Specificity; D014783:Viscosity
chemical_list: D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary