title: Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.
authors.affiliation: Neuronal Cell Biology Laboratory, CME, K.U.Leuven and Flanders Interuniversitary Institute for Biotechnology (VIB4), Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Herreman
authors.forename: L
authors.initials: L
authors.lastname: Serneels
authors.forename: W
authors.initials: W
authors.lastname: Annaert
authors.forename: D
authors.initials: D
authors.lastname: Collen
authors.forename: L
authors.initials: L
authors.lastname: Schoonjans
authors.forename: B
authors.initials: B
authors.lastname: De Strooper
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology; D053829:Amyloid Precursor Protein Secretases; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000378:metabolism*; D004789:Enzyme Activation; D008565:Membrane Proteins / Q000172:deficiency* / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D053764:Presenilin-1; D053766:Presenilin-2; D013234:Stem Cells / Q000201:enzymology* / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D053764:Presenilin-1; D053766:Presenilin-2; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse