Cytotoxic cembrenolide diterpenes from the formosan soft coral lobophytum crassum.
A new cytotoxic cembrenolide diterpene, lobocrassolide (1), and a known cytotoxic cembrenolide, lobohedleolide (2), were isolated from the Formosan soft coral Lobophytum crassum. The structure of compound 1 was determined by 1D and 2D spectral analysis.
Duh
C Y
CY
Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
Wang
S K
SK
Huang
B T
BT
Dai
C F
CF
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001643:Bridged Bicyclo Compounds; D003603:Cytotoxins; D004224:Diterpenes; D005663:Furans; C412928:lobocrassolide; C409627:lobohedleolide