Prevalence of CCR5 and CCR2 HIV-coreceptor gene polymorphisms in Belgium.
Polymorphisms of the chemokine receptor genes CCR5 and CCR2 are associated with resistance to HIV-1 infection or delayed progression to AIDS. Few data are available on their combined prevalence in healthy subjects; we therefore examined the occurrence of CCR5-Delta32 and CCR2-64I polymorphisms in a sample of 310 healthy Belgians. Allele frequencies were 0.119 and 0.074 for CCR5-Delta32 and CCR2-64I, respectively. Genotype distributions for both polymorphisms were found to be in accordance with Hardy-Weinberg equilibrium, but a significant (p = 0.002) linkage disequilibrium between CCR5-Delta32 and CCR2-64I was observed. The high prevalence of CCR5-Delta32 and CCR2-64I in Belgians may need to be taken into account in the design of studies of antiretroviral treatments.
Struyf
F
F
Laboratory of Virology, Department of Microbiology and Immunology, Rega Institute for Medical Research, Leuven, Belgium. frank.struyf@uz.kuleuven.ac.be
Thoelen
I
I
Charlier
N
N
Keyaerts
E
E
Van der Donck
I
I
Wuu
J
J
Van Ranst
M
M
D001530:Belgium; D005787:Gene Frequency; D005838:Genotype; D015497:HIV-1; D006801:Humans; D011110:Polymorphism, Genetic; D015995:Prevalence; D054390:Receptors, CCR2; D019713:Receptors, CCR5 / Q000235:genetics*; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine / Q000235:genetics*; D044465:White People / Q000235:genetics
C515334:CCR2 protein, human; D054390:Receptors, CCR2; D019713:Receptors, CCR5; D019707:Receptors, Chemokine; D018121:Receptors, Cytokine