Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase.
Mice deficient in phox (gp91(phox-/-)) or NOS2 (NOS2(-/-)) were infected with the agent of human granulocytic ehrlichiosis (HGE) to evaluate the importance of these pathways in the eradication of HGE bacteria. NOS2(-/-) mice had delayed clearance of the HGE agent in comparison to control or gp91(phox-/-) mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.
Banerjee
R
R
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Anguita
J
J
Fikrig
E
E
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D004536:Ehrlichia / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D016873:Ehrlichiosis / Q000201:enzymology / Q000209:etiology* / Q000276:immunology; D006098:Granulocytes / Q000201:enzymology / Q000276:immunology; D006801:Humans; D008562:Membrane Glycoproteins / Q000172:deficiency* / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; D019001:Nitric Oxide Synthase / Q000172:deficiency* / Q000235:genetics; D052247:Nitric Oxide Synthase Type II; D009584:Nitrogen / Q000378:metabolism
D017931:DNA Primers; D008562:Membrane Glycoproteins; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C056558:CYBB protein, human; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; D009584:Nitrogen