[A 13-week subchronic oral toxicity study of Perilla extracts in F344 rats].
A 13-week subchronic oral toxicity study of Perilla extracts in drinking water containing 0%, 2.5%, 5% and 10% extracts was performed in both sexes of F344 rats. Rats were randomly divided into 4 groups each consisting of 10 males and 10 females. No animals died during the period of administration. There were no treatment-related changes in body weight gain or in hematological or blood biochemistry values. Nor were any treatment-related histopathological changes observed in the highest dose group. These findings indicate that ingestion of 10% Perilla extracts in drinking water for 13-week does not cause any toxicological changes in rats.
Yun
L
L
Onodera
H
H
Takagi
H
H
Koujitani
T
T
Yasuhara
K
K
Mitsumori
K
K
Hirose
M
M
D000284:Administration, Oral; D000818:Animals; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005503:Food Additives / Q000008:administration & dosage / Q000633:toxicity*; D019686:Lamiaceae / Q000737:chemistry; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013997:Time Factors
D005503:Food Additives; D010936:Plant Extracts