title: Prediction of permanent hearing loss in high-risk preterm infants at term age.
abstract: The aim of this series was to assess hearing screenings; auditory brainstem responses (ABR), transient evoked otoacoustic emissions (TEOAE) and free field auditory responses (FF) for the prediction of permanent bilateral hearing loss in high-risk preterm infants at term post-conceptional age. A total of 51 preterm infants (gestational age < 34 weeks, birth weight < 1500 g) underwent examinations at term and hearing, speech and neurological development were followed up until a corrected age of 18 months. Significant hearing defects were verified by broader ABR examinations under sedation and by clinical ward observation including responsiveness to sounds and enhancement of hearing using an amplification device. Seven bilateral fails in ABR were found, together with nine bilateral fails in TEOAE and four fails in FF screening at term age. Six preterm infants were later confirmed to have a significant permanent bilateral hearing loss, four of whom had also cerebral palsy. Bilateral failure in ABR screening predicted hearing loss with a sensitivity of 100% and a specificity of 98%, TEOAE with a sensitivity of 50% and a specificity of 84% and in the FF examination at the levels of 50% and 98%, respectively.
  
  
  CONCLUSIONS
  Transient evoked otoacoustic emissions alone seem not to be so applicable to the neonatal screening of hearing in high-risk preterm infants as shown earlier in full-term infants, possibly because a hearing defect may be due to retrocochlear damage. Consequently, auditory brainstem response screening seems to be more suitable for very low birth weight preterm infants.
authors.affiliation: Department of Paediatrics, University of Oulu, Finland. marita.valkama@oulu.fi
authors.forename: A M
authors.initials: AM
authors.lastname: Valkama
authors.forename: K T
authors.initials: KT
authors.lastname: Laitakari
authors.forename: E U
authors.initials: EU
authors.lastname: Tolonen
authors.forename: M R
authors.initials: MR
authors.lastname: Väyrynen
authors.forename: L K
authors.initials: LK
authors.lastname: Vainionpää
authors.forename: M E
authors.initials: ME
authors.lastname: Koivisto
mesh_terms: D003638:Deafness / Q000175:diagnosis*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D015997:Neonatal Screening; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity