title: Effects of mimosine on fiber shedding, follicle activity, and fiber regrowth in Spanish goats.
abstract: Ten 2-yr-old Spanish wethers (58.2 +/- 7.21 kg BW) were used to determine effects of 2-d intravenous infusion of mimosine (beginning on January 8) on fiber shedding, follicle activity, and fiber regrowth. Primary and secondary follicle activity on d 0 were 43 +/- 6.2% and 96 +/- 1.7%, respectively. Five wethers were infused with mimosine at 120 mg/(kg BW x d) and the other five received saline. At 7 to 10 d after the start of infusion, all five goats infused with mimosine exhibited shedding, whereas shedding by controls was not observed. Cashmere fiber shedding score (5-point scale: 1 = no shedding, 5 = excessive shedding) on d 4 was greater for mimosine goats than for controls (1.2 vs 2.0; P < .001), and shedding score for wethers receiving mimosine was greater (P < .05) on d 12, 16, and 20 than on d 0 and 4 (4.1 to 4.6 vs 1.4 and 2.0). Guard hair shedding score for goats receiving mimosine was greatest (P < .01) among the days after infusion for d 12 and greater (P < .01) on d 16 than on d 0 and 4. Nonetheless, cashmere fiber yield from combed fleece of mimosine goats (average of 73%) was much greater than for a clipping of the uncombed side (average of 28%) when the cashmere fiber shedding score exceeded 4.0. Secondary follicle activity on d 12 was lower (P < .01) for mimosine than for control wethers (6.8 vs 67.7%), and secondary follicle activity for mimosine-infused goats on d 12 was lower (P < .01) than on d 0 (98.9%), 4 (98.3%), and 20 (99.5%). Mimosine infusion resulted in no detectable fiber regrowth in wk 4 to 7 after the start of infusion, but regrowth rate in the following two 4-wk periods was similar for mimosine and control wethers. In conclusion, 2-d intravenous infusion of mimosine at 120 mg/(kg BW x d) in the winter induced cashmere shedding but had less effect on guard hairs, suggesting future potential use of chemicals such as mimosine to remove cashmere fiber.
authors.affiliation: E (Kika) de la Garza Institute for Goat Research, Langston University, OK 73050, USA.
authors.forename: J
authors.initials: J
authors.lastname: Luo
authors.forename: A J
authors.initials: AJ
authors.lastname: Litherland
authors.forename: T
authors.initials: T
authors.lastname: Sahlu
authors.forename: R
authors.initials: R
authors.lastname: Puchala
authors.forename: M
authors.initials: M
authors.lastname: Lachica
authors.forename: A L
authors.initials: AL
authors.lastname: Goetsch
mesh_terms: D000818:Animals; D006041:Goats / Q000502:physiology*; D006197:Hair / Q000187:drug effects* / Q000254:growth & development; D018859:Hair Follicle / Q000187:drug effects / Q000254:growth & development; D008297:Male; D008898:Mimosine / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D008898:Mimosine