Protein S-100beta: a biochemical marker for increased intracranial pressure in pigs with acute hepatic failure.
BACKGROUND
Acute hepatic failure (AHF) may cause encephalopathy. Intracranial pressure (ICP) is frequently monitored to guide therapy, but such monitoring may cause intracerebral haemorrhagic complications. We hypothesize that determination of serum levels of S-100beta, a protein synthesized in astroglial cells, will provide useful clinical information on the presence and extent of intracranial hypertension in AHF.


METHODS
Continuous intraparenchymatous ICP monitoring and serial S-100beta measurements in serum were performed in 11 Norwegian Landrace pigs with surgically induced AHF and in 4 sham-operated controls.


RESULTS
ICP increased hour by hour in the devascularized pigs in parallel with increased serum levels of protein S-100beta. In the sham-operated controls S-100beta was not detectable at any time point.


CONCLUSIONS
Serum levels of S-100beta are increased early in experimental AHF. Determination of protein S-100beta may provide useful information on the presence and extent of intracranial hypertension in AHF.
Ytrebø
L M
LM
Dept. of Surgery, Tromsø University Hospital, Norway.
Ingebrigtsen
T
T
Nedredal
G I
GI
Elvenes
O P
OP
Korvald
C
C
Romner
B
B
Revhaug
A
A
D000818:Animals; D015415:Biomarkers / Q000097:blood; D019586:Intracranial Hypertension / Q000175:diagnosis* / Q000209:etiology; D017114:Liver Failure, Acute / Q000097:blood / Q000150:complications*; D009414:Nerve Growth Factors; D011237:Predictive Value of Tests; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013552:Swine
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins