title: The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD170292.
abstract: The design, synthesis and biological actions of a novel, non-peptide CCK1 receptor agonist (PD 170292) which exhibits a similar pharmacological profile to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the structures of a peptide based CCK1 receptor selective agonist and a peptoid CCK2 receptor selective antagonist.
authors.affiliation: CCIPE-Faculte de Pharmacie, Montpellier, France.
authors.forename: N
authors.initials: N
authors.lastname: Bernad
authors.forename: B G
authors.initials: BG
authors.lastname: Burgaud
authors.forename: D C
authors.initials: DC
authors.lastname: Horwell
authors.forename: R A
authors.initials: RA
authors.lastname: Lewthwaite
authors.forename: J
authors.initials: J
authors.lastname: Martinez
authors.forename: M C
authors.initials: MC
authors.lastname: Pritchard
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002956:Citrulline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D034444:Peptoids; D051381:Rats; D011949:Receptors, Cholecystokinin / Q000819:agonists*
chemical_list: C414945:PD 170292; D034444:Peptoids; D011949:Receptors, Cholecystokinin; D002956:Citrulline; D000218:Adamantane