[Intracellular cAMP involvement in the synchronized activity of noradrenaline in response to evoked release of the transmitter quanta in the frog synapses].
An analogue of cyclic AMP (db-cAMP) penetrating into the frog neuromuscular junction's cell, as well as the adenylyl cyclase activator forskolin, and inhibitor of nucleotide-depending phosphodiesterase isobutilmethylxantine alter the kinetics of the quanta secretion resulting in synchronizing of the process of the transmitter release. Following a db-cAMP preliminary action, no such synchronizing of the transmitter release occurred. Action of noradrenaline on the time course of the secretion seems to be realised through activation of presynaptic beta-adrenoreceptors, augmentation of the adenylyl cyclase activity, and the rise of the intracellular cAMP.
Bukharaeva
E A
EA
Kazan State Medical University.
Samigullin
D V
DV
Nikol'skiĭ
E E
EE
Vyskocil
F
F
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D003994:Bucladesine / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004558:Electric Stimulation; D004594:Electrophysiology; D004789:Enzyme Activation; D009469:Neuromuscular Junction / Q000378:metabolism / Q000648:ultrastructure; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D011895:Rana ridibunda; D013569:Synapses / Q000378:metabolism* / Q000502:physiology / Q000648:ultrastructure
D018377:Neurotransmitter Agents; D010726:Phosphodiesterase Inhibitors; D005576:Colforsin; D003994:Bucladesine; D000242:Cyclic AMP; D000262:Adenylyl Cyclases; D015056:1-Methyl-3-isobutylxanthine; D009638:Norepinephrine
Uchastie vnutrikletochnogo tsAMF v realizatsii sinkhroniziruiushchego deĭstviia noradrenalina na vyzvannoe osvobozhdeniie kvantov mediatora v sinapsakh liagushki.