title: Susceptibilities of Yersinia pestis strains to 12 antimicrobial agents.
abstract: Ninety-two strains of Yersinia pestis recovered over a 21-year period were evaluated for susceptibility to traditional and newer antimicrobial agents. In vitro resistance was noted only against rifampin and imipenem (approximately 20% of strains). The most active compounds (MIC at which 90% of the isolates tested are inhibited) against Y. pestis were cefixime, ceftriaxone, trimethoprim-sulfamethoxazole, and trovafloxacin.
authors.affiliation: Microbial Diseases Laboratory, Division of Communicable Disease Control, California Department of Health Services, Berkeley, California 94704-1011, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Wong
authors.forename: J R
authors.initials: JR
authors.lastname: Barash
authors.forename: R F
authors.initials: RF
authors.lastname: Sandfort
authors.forename: J M
authors.initials: JM
authors.lastname: Janda
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D020682:Cefixime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015010:Yersinia pestis / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002443:Ceftriaxone; D020682:Cefixime