Searching for genetic determinants in the new millennium.
Human genetics is now at a critical juncture. The molecular methods used successfully to identify the genes underlying rare mendelian syndromes are failing to find the numerous genes causing more common, familial, non-mendelian diseases. With the human genome sequence nearing completion, new opportunities are being presented for unravelling the complex genetic basis of non-mendelian disorders based on large-scale genome-wide studies. Considerable debate has arisen regarding the best approach to take. In this review I discuss these issues, together with suggestions for optimal post-genome strategies.
Risch
N J
NJ
Department of Genetics, Stanford University School of Medicine, California 94305-5120, USA.
D001709:Biotechnology; D019295:Computational Biology; D030342:Genetic Diseases, Inborn / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005826:Genetics, Medical / Q000639:trends*; D015894:Genome, Human; D006801:Humans