title: Paracetamol hepatotoxicity and alcohol consumption in deliberate and accidental overdose.
abstract: We studied the relationship between alcohol consumption and hepatotoxicity related to paracetamol ingestion both in cases of overdose with suicidal intent and in cases where paracetamol was apparently taken for therapeutic reasons. In a retrospective study of 553 patients admitted to a specialist liver unit between January 1987 and December 1993 with paracetamol-induced hepatotoxicity, there was no difference in the severity of the hepatotoxicity following either a deliberate or an inadvertent overdose. Heavy alcohol consumption was more common in males than females and more commonly associated with deliberate overdoses of >15 g. There was no correlation between alcohol consumption and severity of hepatotoxicity (mean INR and the serum creatinine levels over the first 7 days after the overdose). The significantly lower platelet count in heavy drinkers was probably the consequence of direct alcohol toxicity to the marrow. Overall there was a greater incidence of heavy alcohol consumption amongst therapeutic misadventure compared to deliberate overdose cases, but there was no difference between the two groups when amounts of <10 g/day were involved. Eleven (29%) patients in the therapeutic misadventure group were depressed, 10 of whom had previously attempted suicide. In conclusion, we were unable to demonstrate that heavy drinkers develop more severe hepatotoxicity following paracetamol overdose than non-drinkers, and from the material reported in this study, accidental overdose is a better defining term than therapeutic misadventure.
authors.affiliation: Institute of Liver Studies, King's College Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Makin
authors.forename: R
authors.initials: R
authors.lastname: Williams
mesh_terms: D000082:Acetaminophen / Q000506:poisoning*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000378:metabolism*; D018712:Analgesics, Non-Narcotic / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury; D003404:Creatinine / Q000097:blood; D003863:Depression / Q000150:complications; D062787:Drug Overdose; D004357:Drug Synergism; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors; D013406:Suicide, Attempted
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D003404:Creatinine