[Chemopreventive effect of tamoxifen on familial breast cancer].
Chemopreventive effect of tamoxifen on familial breast cancer was studied. As it is impossible to use medicines for prevention of human breast cancer in Japan, a lot of investigations on animals using natural foods like as green tea, seaweed etc has been done. Seaweed wakame was effective on breast cancer proliferation in rat. In this paper 3 reports(Fisher, Powles and Veronesi) were reviewed and the results of some Japanese investigations in chemoprevention on animals were introduced. In Fisher's report tamoxifen was effective on breast cancer prevention, however in other 2 reports no effects were noticed because of the difference of risk. Study of Tamoxifen And Raloxifene(STAR) was started by NSABP in 1999.
Funahashi
H
H
Dpt. of Surg. II, Nagoya Univ. Sch. of Med.
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000517:prevention & control*; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000517:prevention & control*; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use; D051381:Rats; D012624:Seaweed; D013629:Tamoxifen / Q000627:therapeutic use*; D013662:Tea
D004965:Estrogen Antagonists; D013662:Tea; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride