[Nitrogen oxide storage as a factor of adaptive defence].
Adaptation to environmental factors possesses multiple NO-dependent protective effects and stimulates the NO storage. An adaptation to a mild stress was shown to reduce the death rate in rats from 57% to 8% and to prevent a heat shock-induced hypotension and endothelial overactivation. Treatment of the rats with the NO-synthase inhibitor L-NNA interfered with the NO storage and formation of protective effects, while the NO donor dinitrosyl iron complex facilitated the NO storage and simulated the adaptive defence. The data obtained suggest an important role of the NO storage in adaptive defence of the organism.
Smirin
B V
BV
Research Institute of General Pathology and Pathophysiology of the Russian Acad. Med. Sci., Russia, Moscow.
Pokidyshev
D A
DA
Malyshev
I Iu
IIu
Vanin
A F
AF
Manukhina
E B
EB
D000222:Adaptation, Physiological; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D018869:Heat-Shock Response; D007103:Immobilization; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology; D009126:Muscle Relaxation; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000378:metabolism* / Q000401:mortality / Q000503:physiopathology
D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D009589:Nitrogen Oxides; D019335:Nitroarginine; D009569:Nitric Oxide; C073661:dinitrosyl iron complex; D007501:Iron; D019001:Nitric Oxide Synthase
Deponirovanie oksida azota kak faktor adaptivnoĭ zashchity]