title: Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?
abstract: OBJECTIVE
  Obsessive-compulsive disorder (OCD) is a psychiatric condition for which strong evidence of a genetic component and serotonergic system involvement exists. Recent studies have shown that sumatriptan, a selective ligand of the serotonin (5-HT)(1Dbeta) autoreceptor, modifies OCD symptoms. The aim of this study was to investigate the presence of linkage disequilibrium between the 5-HT(1Dbeta) receptor gene, which has a variant caused by a silent G to C substitution at nucleotide 861 of the coding region, and OCD.
  
  
  METHODS
  DNA was collected from 67 probands who met DSM-IV criteria for OCD and from their living parents or siblings. Transmission Disequilibrium Test/sib-Transmission Disequilibrium Test analyses were then conducted with the DNA data.
  
  
  RESULTS
  Thirty-two families were informative for the analysis, which showed a preferential transmission of the G allele to the affected subjects.
  
  
  CONCLUSIONS
  If the results are confirmed, there may be important implications for the 5-HT(1Dbeta) receptor gene in the pathogenesis and treatment of OCD.
authors.affiliation: Neurogenetics Section, University of Toronto, Ontario, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Mundo
authors.forename: M A
authors.initials: MA
authors.lastname: Richter
authors.forename: F
authors.initials: F
authors.lastname: Sam
authors.forename: F
authors.initials: F
authors.lastname: Macciardi
authors.forename: J L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D017660:Autoreceptors / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000187:drug effects / Q000235:genetics*; D018170:Sumatriptan / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D017660:Autoreceptors; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D018170:Sumatriptan