title: SprE levels are growth phase regulated in a sigma(S)-dependent manner at the level of translation.
abstract: SprE regulates sigma(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is sigma(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and sigma(S) function within a regulatory feedback loop.
authors.affiliation: Department of Molecular Biology, Princeton University, NJ 08544, USA.
authors.forename: K E
authors.initials: KE
authors.lastname: Gibson
authors.forename: T J
authors.initials: TJ
authors.lastname: Silhavy
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D004268:DNA-Binding Proteins; D004926:Escherichia coli / Q000254:growth & development*; D029968:Escherichia coli Proteins; D015964:Gene Expression Regulation, Bacterial; D014176:Protein Biosynthesis; D012808:Sigma Factor / Q000378:metabolism*; D014157:Transcription Factors
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D012808:Sigma Factor; D014157:Transcription Factors; C098923:rssB protein, E coli; C069567:sigma factor KatF protein, Bacteria