title: Viral load in Indonesian patients with chronic liver disease and in blood donors infected with different subtypes of hepatitis C virus.
abstract: The viral load of different hepatitis C virus (HCV) subtypes, including the globally distributed HCV-1b and the unique Indonesian subtype HCV-1c, was analyzed using serum samples obtained from Indonesian blood donors and patients with chronic liver disease. The mean viral load of HCV-1c was comparable with that of HCV-1b, suggesting that HCV-1c is as pathogenic as HCV-1b. On the other hand, the mean viral load of HCV-2a was lower than that of HCV-1b or HCV-1c, with this result being consistent with previous observations. Interestingly, some HCV-2a strains were associated with a high viral load that was almost equivalent to that of HCV-1b and HCV-1c. This result implies the possibility that there exists a minor fraction of HCV-2a strains that cause higher levels of viremia compared with the majority of ordinary HCV-2a strains.
authors.affiliation: Tropical Disease Center, Airlangga University, Surabaya, Indonesia.
authors.forename: M I
authors.initials: MI
authors.lastname: Lusida
authors.lastname: Soetjipto
authors.forename: R
authors.initials: R
authors.lastname: Handajani
authors.forename: C A
authors.initials: CA
authors.lastname: Nidom
authors.lastname: Soemarto
authors.forename: S
authors.initials: S
authors.lastname: Darmadi
authors.forename: P
authors.initials: P
authors.lastname: Adi
authors.forename: M
authors.initials: M
authors.lastname: Fujii
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Ishido
authors.forename: H
authors.initials: H
authors.lastname: Hotta
mesh_terms: D000328:Adult; D001782:Blood Donors; D016174:Hepacivirus / Q000145:classification* / Q000472:pathogenicity; D019698:Hepatitis C, Chronic / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D019562:Viral Load; D014766:Viremia / Q000175:diagnosis / Q000821:virology
chemical_list: D012367:RNA, Viral