New lipids from the tunicate Cystodytes cf. dellechiajei, as PLA2 inhibitors.
Cystodytes cf. dellechiajei collected off Djerba furnished new lipids, sphingosines 1, as inhibitors of phospholipase A2, along with inactive homologous ceramides 2. Structures were determined by spectroscopic methods and chemical transformations.
Loukaci
A
A
Laboratoire de Chimie des Substances Naturelles, ESA 8041 CNRS, Museum National d'Histoire Naturelle, 63 Rue Buffon, F-75005 Paris, France.
Bultel-Poncé
V
V
Longeon
A
A
Guyot
M
M
D000818:Animals; D017839:Crotalus; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D008956:Models, Chemical; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D013110:Sphingosine / Q000737:chemistry / Q000494:pharmacology*; D014416:Tunisia; D014561:Urochordata / Q000737:chemistry*
D004791:Enzyme Inhibitors; D010741:Phospholipases A; D054467:Phospholipases A2; D013110:Sphingosine