Stability of extemporaneous norfloxacin suspension.
The stability of norfloxacin as extemporaneous suspensions compounded from two brands of film-coated tablets (formulas I and II) was studied. The vehicle consisted of tragacanth, saccharin sodium, sorbitol solution, glycerin, paraben concentrate, peppermint spirit BP, purified water, and syrup USP. The final concentration of norfloxacin in the suspensions was 20 mg/ml. Formulas I and II were chemically stable for 28 days when stored in amber glass bottles at ambient temperature; however, their physical characteristics were different.
Boonme
P
P
Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
Phadoongsombut
N
N
Phoomborplub
P
P
Viriyasom
S
S
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000032:analysis; D009643:Norfloxacin / Q000008:administration & dosage* / Q000032:analysis; D013535:Suspensions; D013607:Tablets
D004791:Enzyme Inhibitors; D013535:Suspensions; D013607:Tablets; D009643:Norfloxacin