[The mechanisms of the GABA-ergic regulation of beta-endorphin levels in the hypothalamic structures of prenatally stressed male rats].
The effect of GABA receptors agonists on the stress-induced beta-endorphin levels in the preoptic area and mediobasal hypothalamus of the intact and prenatally stressed male albino rats was studied. It has been found out that stimulation of GABAa-receptor complex by means of the muscimol leads to increasing of beta-endorphin levels in the preoptic area and mediobasal hypothalamus of the control animals. GABAb receptor activation by means of the baclofen decreases opioids level in the mediobasal hypothalamus. Prenatal stress eliminates stimulant effect of the muscimol on beta-endorphin levels in the investigated brain structures and leads to the opioid level decreasing after baclofen influence in preoptic area.
Tkachuk
S S
SS
Bukovinian State Medical Academy, Ministry of Public Health of Ukraine, Chernivtsi.
Pishak
V P
VP
Myslyts'kyĭ
V F
VF
D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology; D001923:Brain Chemistry / Q000187:drug effects; D005260:Female; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology; D007033:Hypothalamus, Middle / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011301:Preoptic Area / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D018079:Receptors, GABA / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D001615:beta-Endorphin / Q000032:analysis / Q000187:drug effects / Q000502:physiology*
D018755:GABA Agonists; D018079:Receptors, GABA; D009118:Muscimol; D001615:beta-Endorphin; D001418:Baclofen
Mekhanizmy HAMK-erhichnoï rehuliatsi rivniv beta-endorfinu v strukturakh hipotalamusa prenatal'no stressovanykh samtsiv shchuriv.