[Evaluation for biocompatibility of poly-(3-hydroxypropyl)-DL-aspartamide].
To evaluate the biocompatibility of poly-(3-hydroxypropyl)-DL-aspartamide(PHPA), we utilized the laboratory methods, including subcutaneous implantation, histological examination, blood biochemical and micronucleus test. Histological examination revealed a nonspecific foreign body reaction around the PHPA and a slight inflammation around the small blood vessels of the liver on the 13th day, but all these reactions diminished or disappeared gradually after 34 days of implantation. The structures and functions of liver and kidney were normal. The results indicate that PHPA possesses a good nature in biocompatibility.
Weng
L
L
Department of Histology and Embryology, Zhejiang University, Hangzhou.
Tang
G
G
Zhou
J
J
Wang
B
B
Zhou
T
T
Chen
Q
Q
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001672:Biocompatible Materials / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D006400:Hematocrit; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D010455:Peptides / Q000633:toxicity*
D001672:Biocompatible Materials; D010455:Peptides; C411105:poly(3-hydroxypropyl)aspartamide; D000410:Alanine Transaminase