Involvement of nitric oxide (NO) in hypoglycaemic activity of tolbutamide.
The study was conducted to find the involvement of Nitric Oxide (NO) using L-arginine, a NO precursor and NG-methyl L-arginine a nitric oxide synthase inhibitor on tolbutamide activity in normal rabbits. L-arginine (25-300 mg/kg, body weight, oral) produced transient and dose dependent hypoglycaemia. When combined with tolbutamide (40 mg/kg, oral) it produced early and prolonged action. The effect of tolbutamide was blocked by NG-methyl L-arginine (5 mg/kg, body weight, oral). The results confirm the involvement of NO in tolbutamide activity and the possibility of using L-arginine as a supplement to antidiabetic drugs in blood glucose control.
Satyanarayana
S
S
Department of Pharmaceutical Sciences, College of Engineering, Andhra University, Visakhapatnam.
Krishnaiah
Y S
YS
Rao
B K
BK
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects*; D005260:Female; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide / Q000502:physiology*; D011817:Rabbits; D014044:Tolbutamide / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009569:Nitric Oxide; D001120:Arginine; D014044:Tolbutamide