title: Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor.
abstract: The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.
authors.affiliation: Toyama Medical and Pharmaceutical University, Sugitani, Japan. takahata@ms.toyama-mpu.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Takahata
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Azer
authors.forename: A T
authors.initials: AT
authors.lastname: Eldefrawi
authors.forename: M E
authors.initials: ME
authors.lastname: Eldefrawi
mesh_terms: D000818:Animals; D001001:Anura; D011485:Protein Binding; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D014101:Torpedo
chemical_list: D011763:Pyrrolizidine Alkaloids; D011978:Receptors, Nicotinic