title: A model of mechanobiologic and metabolic influences on bone adaptation.
abstract: Bone adaptation, the process through which bone mass is modified in the body, plays a key role in the development of osteoporosis. Bone adaptation is known to be influenced by both mechanical and metabolic stimuli. Previous studies have concentrated on changes in bone adaptation caused by mechanical stimuli (mechanobiologic influences), yet current treatments for osteoporosis depend significantly on metabolic influences. We develop a theoretical model of bone adaptation that accounts for both mechanobiologic and metabolic influences. We demonstrate the utility of this model using a simulation of the cellular processes of bone adaptation on a representative volume of cancellous bone. Our long-term objective is the development of a more comprehensive computational model that will aid in the study of osteoporosis and other bone diseases.
authors.affiliation: SRehabilitation Research and Development Center, Veterans Administration Palo Alto Health Care System, CA 94304-1200, USA. chernand@Stanford.edu
authors.forename: C J
authors.initials: CJ
authors.lastname: Hernandez
authors.forename: G S
authors.initials: GS
authors.lastname: Beaupré
authors.forename: D R
authors.initials: DR
authors.lastname: Carter
mesh_terms: D000222:Adaptation, Physiological; D001696:Biomechanical Phenomena; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism* / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D010024:Osteoporosis / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical