Three-dimensional MR imaging of pulmonary vessels and parenchyma with NC100150 injection (Clariscan).
The influence of increasing doses of NC100150 Injection (Clariscantrade mark) and echo times on visualization of pulmonary vessels and parenchyma was evaluated. The effects of 0.5, 1, 2, 4, and 8 mg Fe/kg NC100150 Injection and echo times (TE) of 1.1, 1.8, 2. 2, and 4.3 msec were determined in six dogs using breath-hold three-dimensional (3D) spoiled gradient-echo magnetic resonance (MR) sequence. At 2 mg Fe/kg and TE of 1.1 msec, the signal-to-noise ratio of the central pulmonary arteries and parenchyma was significantly increased (5.3 +/- 2.2 to 50.3 +/- 2.4) and (2.2 +/- 0. 9 to 6.4 +/- 1.1), respectively. Using the TE of 1.1 msec, signal intensity in the main arteries continued to increase with increasing dose. Moreover, the enhancement of pulmonary parenchyma and microvasculature had a positive dose response. 3D MR imaging with ultrashort echo time and 2 mg Fe/kg NC100150 Injection produces angiograms with strong vascular contrast and allows qualitative assessment of pulmonary parenchyma and microvasculature.
Bremerich
J
J
Department of Radiology, University of California San Francisco, San Francisco, California 94143-0628, USA.
Roberts
T P
TP
Wendland
M F
MF
Wyttenbach
R
R
Arheden
H
H
Reddy
G P
GP
Shafaghi
N
N
Higgins
C B
CB
Saeed
M
M
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D003911:Dextrans; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D052203:Ferrosoferric Oxide; D007089:Image Enhancement / Q000379:methods*; D007501:Iron; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis; D018810:Magnetic Resonance Angiography / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D010087:Oxides; D011336:Probability; D011651:Pulmonary Artery / Q000473:pathology*; D011652:Pulmonary Circulation; D012680:Sensitivity and Specificity
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide