title: Respiratory changes in vasovagal syncope.
abstract: BACKGROUND
  Respiratory changes accompany the cardiovascular changes during head-up, tilt test-induced vasovagal syncope.
  
  
  RESULTS
  Using the 45-minute 60 degrees head-up Westminster protocol, 29 patients were studied (mean age 53.9+/-20.0 years; 19 females). Two groups resulted: tilt-induced vasovagal syncope positive and negative. The cardiorespiratory parameters blood pressure (BP), heart rate (HR), tidal volume, and minute volume were measured. Comparisons of the cardiorespiratory parameters were made within the positive group and negative group, and then between the two groups. There were 14 in the positive group and 15 in the negative group. Baseline measurements were normalized to 1.0. Comparing the late tilt periods between the positive and negative groups, there were differences in BP (P < 0.002), HR (P < 0.002), tidal volume (P < 0.05), and minute volume (P < 0.002). In the positive group comparing early with late intervals: BP 1.11+/-0.09 versus 0.49+/-0.17, P < 0.0001; HR 1.18+/-0.12 versus 0.85+/-0.35, P < 0.009; tidal volume 1.39+/-0.34 versus 2.17+/-1.00, P < 0.015; and minute volume 1.24+/-0.26 versus 3.3+/-2.03, P < 0.0025. There were no comparable cardiorespiratory changes in the negative group.
  
  
  CONCLUSIONS
  There were significant differences in the respiratory and cardiovascular parameters measured between those who were positive and those who were negative for tilt-induced vasovagal syncope. Within the positive group, in addition to the falls in HR and BP, there were significant increases in minute volume and tidal volume during late tilt. This suggests that there may be a role for respiratory sensors in vasovagal syncope that may permit earlier and hence possibly more effective therapy for selected patients.
authors.affiliation: Department of Cardiology, London Chest Hospital, United Kingdom. a_kurbaan@hotmail.com
authors.forename: A S
authors.initials: AS
authors.lastname: Kurbaan
authors.forename: M
authors.initials: M
authors.lastname: Erickson
authors.forename: M E
authors.initials: ME
authors.lastname: Petersen
authors.forename: A C
authors.initials: AC
authors.lastname: Franzén
authors.forename: Z
authors.initials: Z
authors.lastname: Stack
authors.forename: T
authors.initials: T
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Sutton
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology; D005260:Female; D018475:Head-Down Tilt; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012119:Respiration; D019462:Syncope, Vasovagal / Q000209:etiology / Q000503:physiopathology*; D013990:Tidal Volume