Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol.
Introduction of a senecioyl group into shinjulactones B and C, and esterification of the diosphenol moiety in brusatol and brucein A enhanced inhibitory effect against Epstein-Barr virus early antigen activation.
Tamura
S
S
Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.
Fukamiya
N
N
Mou
X Y
XY
Mukainaka
T
T
Tokuda
H
H
Nishino
H
H
Tagahara
K
K
Koike
K
K
Lee
K H
KH
Okano
M
M
D000956:Antigens, Viral / Q000187:drug effects*; D004951:Esterification; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D010636:Phenols / Q000737:chemistry*; D013057:Spectrum Analysis
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D005419:Flavonoids; D010636:Phenols