Evaluation of carrier agents for hyperpolarized xenon MRI.
Several biocompatible carrier agents, in which xenon is highly soluble and has a long T(1), were tested, and injected in living rats. These included saline, Intralipid suspension, perfluorocarbon emulsion and (129)Xe gas-filled liposomes. The T(1) of (129)Xe in these compounds ranged from 47 to 116 s. Vascular injection of these carrier agents was tolerated well, encouraging their use for further experiments in live animals. In vivo spectra, obtained from gas-filled liposomes and perfluorocarbon solutions, suggest that these carrier agents have potential for use in angiography and perfusion imaging.
Venkatesh
A K
AK
Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Zhao
L
L
Balamore
D
D
Jolesz
F A
FA
Albert
M S
MS
D000818:Animals; D004337:Drug Carriers; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D005466:Fluorocarbons; D008081:Liposomes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014978:Xenon / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014979:Xenon Isotopes
D004337:Drug Carriers; D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D005466:Fluorocarbons; D008081:Liposomes; D014979:Xenon Isotopes; D014978:Xenon