title: Stereotactic radiosurgery of cerebral arteriovenous malformations: appearance of perinidal T(2) hyperintensity signal as a predictor of favorable treatment response.
abstract: The purpose of this study was to analyze the significance of perinidal T(2) hyperintensity appearance after radiosurgery of arteriovenous malformations (AVMs), as a predictor of treatment response. Our initial experience with linear accelerator (LINAC) radiosurgery at University of California, Los Angeles, between 1990 and 1997 involved treatment of 129 patients affected by cerebral AVMs. Based upon availability of neuroimaging follow-up, 48 patients with 50 AVMs were selected for review. Forty (80%) of the AVMs underwent complete obliteration or significant reduction on follow-up MRI, on average 20 months after radiosurgery. Thirteen (72%) of 18 obliterated AVMs were associated with perinidal T(2) hyperintensity signal, on average 18 months (6-49) after radiosurgery. Ten (20%) of 50 AVMs (average volume 23.1 cm(3), ranging 7.5-46.5) were unchanged. Furthermore, only 3 AVMs in this group showed reversible T(2) signal changes. In patients with complete nidal obliteration, appearance of T(2) hyperintensity signal achieves 72% sensitivity in predicting successful treatment response.
authors.affiliation: Department of Neurosurgery and Radiation Oncology, School of Medicine, University of California, Los Angeles, USA. fmobin@pol.net
authors.forename: F
authors.initials: F
authors.lastname: Mobin
authors.forename: A A
authors.initials: AA
authors.lastname: De Salles
authors.forename: O
authors.initials: O
authors.lastname: Abdelaziz
authors.forename: C
authors.initials: C
authors.lastname: Cabatan-Awang
authors.forename: T
authors.initials: T
authors.lastname: Solberg
authors.forename: M
authors.initials: M
authors.lastname: Selch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016634:Radiosurgery; D012680:Sensitivity and Specificity; D013238:Stereotaxic Techniques; D016896:Treatment Outcome