Interaction of amyloid precursor proteins and heme oxygenase.
Amyloid precursor protein generates the beta-amyloid peptide and is a member of a multigene family that contains at least two other gene products, known as amyloid precursor-like proteins. Heme oxygenase is an enzyme whose products are antioxidant and neuroprotective. The authors report that amyloid precursor protein and amyloid precursor-like protein bind to heme oxygenase to inhibit its enzymatic activity. Our findings suggest that decreased neuroprotection caused by amyloid precursor protein-heme oxygenase interactions influences neurotoxicity in Alzheimer disease.
Takahashi
M
M
Department of Neuroscience, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.
Snyder
S H
SH
D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D009498:Neurotoxins / Q000009:adverse effects; D018384:Oxidative Stress; D051381:Rats
D016564:Amyloid beta-Protein Precursor; D009498:Neurotoxins; D006419:Heme Oxygenase (Decyclizing)