title: Decreased superoxide dismutase expression and increased concentrations of lipid peroxide and prostaglandin F(2alpha) in the decidua of failed pregnancy.
abstract: To study the possible role of the superoxide radical and its scavenging system in the decidua of early pregnancy, superoxide dismutase (SOD) values and concentrations of lipid peroxide and prostaglandin F(2alpha) (PGF(2alpha)) were analysed in the decidua obtained from normal pregnancy and failed pregnancy. Failed pregnancy was divided into two groups; spontaneous abortion with or without vaginal bleeding. In the spontaneous abortion with vaginal bleeding, total SOD activities, Cu,Zn-SOD activities and Cu,Zn-SOD mRNA values in the decidua were significantly lower, and concentrations of lipid peroxide and PGF(2alpha) were significantly higher, than those in the normal pregnancy and the spontaneous abortion without vaginal bleeding. In contrast, activities and mRNA values of Mn-SOD were significantly higher in the spontaneous abortion with vaginal bleeding than the other two groups. There was no significant difference in all of these parameters between the normal pregnancy and the spontaneous abortion without vaginal bleeding. In conclusion, the decrease in Cu,Zn-SOD expression and the increase in lipid peroxide in the decidua could be involved in the termination of spontaneous abortion, mediated through the increase in PGF(2alpha) synthesis. In other words, Cu,Zn-SOD may contribute to the maintenance of pregnancy by preventing the accumulation of superoxide radicals that cause PGF(2alpha) synthesis.
authors.affiliation: Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Japan. obgyn@po.cc.yamaguchi-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Sugino
authors.forename: M
authors.initials: M
authors.lastname: Nakata
authors.forename: S
authors.initials: S
authors.lastname: Kashida
authors.forename: A
authors.initials: A
authors.lastname: Karube
authors.forename: S
authors.initials: S
authors.lastname: Takiguchi
authors.forename: H
authors.initials: H
authors.lastname: Kato
mesh_terms: D000022:Abortion, Spontaneous / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D003656:Decidua / Q000378:metabolism* / Q000473:pathology; D015237:Dinoprost / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis*; D011247:Pregnancy; D013482:Superoxide Dismutase / Q000096:biosynthesis*
chemical_list: D008054:Lipid Peroxides; D015237:Dinoprost; D013482:Superoxide Dismutase