The influence of new polyester block copolymer on morphology of hepatocytes of rats liver.
The liver is a complex organ with metabolic, excretory, and defence functions, so the effect of toxic polymers is often find in disorganisation of hepatic structure and may induce cell damage. In this study it is estimated the influence of recently synthesised multiblock copolymers based on poly/butylene terepthalate) and a dimerized fatty acid. The films of polymers were implanted intra-abdominally in 45 rats of Wistar breed covering the right lobe of liver. The specimens of liver were collected in 1, 3 and 6 day of experiment in order to be evaluated under microscope. The morphology of lobules, size and shape of hepatocytes, size and shape of nuclei's of hepatocytes, any infiltration of plasma cell were taken into account during examination. There have been no difference in morphology between specimens of liver from rats with implanted polymer and control group which could implicate their toxicity.
Prowans
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Clinic of General Surgery and Hand Surgery Pomeranian Medical University, Szczecin.
el Fray
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Deskur
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Dobrzycki
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W
D000005:Abdomen / Q000601:surgery; D000818:Animals; D001672:Biocompatible Materials; D007813:Laparotomy; D008099:Liver / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D011091:Polyesters / Q000494:pharmacology*; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
D001672:Biocompatible Materials; C059046:Hytrel; D011091:Polyesters