title: [Familial variability in the clinical expression of hand-foot-mouth disease].
abstract: Aim of the paper is to describe the variability of clinical symptoms in hand, foot and mouth disease, especially among patients belonging to the same family. In spring 1999, during an epidemic of hand, foot and mouth disease, nineteen cases were observed by the authors. In eight cases also some members of the family were affected. A great variability in the clinical expression of the disease, above all among the members of the same family were observed. No cases in children below twelve months or in elderly members of the family were found. Children below three years had more stressed general symptoms, but in no case hospitalization was necessary. Hand, foot and mouth disease does not always show vesicles and aphthae in the affected areas. Clinical expression can also be lacking, but in this case diagnosis can be made easy by the presence of an epidemic or of other cases in the same family.
authors.affiliation: Divisione Pediatrica, Ospedale S. Andrea, Vercelli.
authors.forename: A
authors.initials: A
authors.lastname: Guala
authors.forename: T
authors.initials: T
authors.lastname: Silvestri
authors.forename: F
authors.initials: F
authors.lastname: Festa
authors.forename: E
authors.initials: E
authors.lastname: Colombo
mesh_terms: D002675:Child, Preschool; D006232:Hand, Foot and Mouth Disease / Q000175:diagnosis* / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010375:Pedigree
vernacular_title: Variabilità intrafamiliare della malattia mani-piedi-bocca.