Progress toward the development of a vaccine to prevent Moraxella (Branhamella) catarrhalis infections.
Moraxella catarrhalis is a major cause of otitis media and respiratory disease. Vaccine development is at the antigen identification stage. This review examines the more promising antigens, including the 200K protein, the hemagglutinins, the lactoferrin-binding proteins, the UspA proteins, the CopB protein, the transferrin-binding proteins, the CD protein, the E protein and lipooligosaccharide conjugates. Clinical testing of some of these antigens should begin soon.
McMichael
J C
JC
Wyeth-Lederle Vaccines, 211 Bailey Road, West Henrietta, NY 14586-9728, USA.
D000818:Animals; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000302:isolation & purification; D001428:Bacterial Vaccines / Q000276:immunology*; D002352:Carrier Proteins / Q000737:chemistry / Q000302:isolation & purification; D027682:Cation Transport Proteins; D006388:Hemagglutinins / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D033862:Iron-Binding Proteins; D008070:Lipopolysaccharides / Q000276:immunology; D001936:Moraxella catarrhalis / Q000276:immunology* / Q000472:pathogenicity; D016870:Neisseriaceae Infections / Q000517:prevention & control*; D033863:Transferrin-Binding Proteins; D018074:Vaccines, Conjugate / Q000276:immunology
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D006388:Hemagglutinins; D033862:Iron-Binding Proteins; D008070:Lipopolysaccharides; D033863:Transferrin-Binding Proteins; C089675:UspA protein, Moraxella catarrhalis; D018074:Vaccines, Conjugate; C023023:lipid-linked oligosaccharides