title: Assessment of the Sydney System in Helicobacter pylori-associated gastritis in children.
abstract: OBJECTIVE
  The aim of our study was to establish the usefulness of the Sydney System in grading H. pylori-associated chronic gastritis in biopsies from pediatric patients.
  
  
  METHODS
  Fifteen children (average age: 10.8 years) with histologically-proven gastritis were studied. Classification and grading of gastritis were performed according to the analogue visual scales described in the updated version of the Sydney System. A chart was specially designed to record the morphological grading in this study. Altogether, we studied 79 gastric biopsies.
  
  
  RESULTS
  Neutrophilic infiltrates were absent in 27 biopsies, mild in 35, and moderate in 17. This feature was not marked in any of the biopsies. Mononuclear infiltrates were mild in 38 biopsies, moderate in 36, and marked in 5. Density of H. pylori was mild in 39 biopsies, moderate in 27, and marked in 2. In three post-treatment biopsies belonging to the same patient, no H. pylori was observed. Additional 8 biopsies (7 from the body and 1 from the antrum) showed no H. pylori, although organisms were simultaneously present in other stomach sites. Lymphoid follicles were present in 19/79 biopsies. Intestinal metaplasia was not seen on slides stained with hematoxylin-eosin (HE). However, the Alcian blue-PAS stain revealed isolated positive cells in 8 out of 15 patients. None of the gastric biopsies showed mucosal atrophy.
  
  
  CONCLUSIONS
  The results show that the Sydney System is applicable for pediatric patients in case of H. pylori-associated gastritis. However, the number of biopsies recommended in the Sydney System seems excessive for this age group.
authors.affiliation: Hospital de Niños Sup. Sor María Ludovica Department of Pathology, La Plata, Buenos Aires, Argentina. patologi@netverk.com.ar
authors.forename: M C
authors.initials: MC
authors.lastname: Cohen
authors.forename: E
authors.initials: E
authors.lastname: Cueto Rúa
authors.forename: N
authors.initials: N
authors.lastname: Balcarce
authors.forename: J
authors.initials: J
authors.lastname: Donatone
authors.forename: R
authors.initials: R
authors.lastname: Drut
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000592:standards; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005069:Evaluation Studies as Topic; D005260:Female; D005756:Gastritis / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000473:pathology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D013270:Stomach / Q000473:pathology*