title: 7alpha-hydroxytheonellasterol, a cytotoxic 4-methylene sterol from the Philippines sponge Theonella swinhoei.
abstract: A new 4-methylene sterol, 7alpha-hydroxytheonellasterol (3), was isolated from the Philippines sponge Theonella swinhoei, along with the known compounds theonellasterol (1) and bistheonellide A. The structure of 3 was elucidated by interpretation of its spectroscopic data, which were compared with those of 1.
authors.affiliation: Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212, USA.
authors.forename: A
authors.initials: A
authors.lastname: Qureshi
authors.forename: D J
authors.initials: DJ
authors.lastname: Faulkner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: C412852:7-hydroxytheonellasterol; D000970:Antineoplastic Agents; D018942:Macrolides; D013261:Sterols; C104924:bistheonellide A