title: Segmental degradation of left ventricular wall motion after persistent coronary fistula in a posttransplantation patient: a case report and short review of literature.
abstract: A 50-year-old man received an orthotopic heart transplant because of severe coronary heart disease and congestive heart failure. Two years after the transplantation, a continuous murmur occurred at the left sternal edge after repeated endomyocardial biopsies. Echocardiography and coronary angiography revealed a dilated left anterior descending artery with a fistula to the right ventricle. The circumflex was large with an equally postero-lateral branch, and the right coronary artery was rather small with collaterals to the distal part of the left anterior descending branch. The patient had refused any intervention to close the fistula. The left ventricular levogram was normal. Two years later, in a follow-up angiogram, the left ventricular ejection fraction had decreased as a result of hypo- and akinesis of the apex and posterior wall. We suggest that this local wall motion disturbance derives from a steal phenomenon rather than being a sequela of rejection. The decrease in left ventricular ejection fraction was associated with shortness of breath upon moderate exercise. Standard heart failure medication relieved the patient's symptoms. The observation of local wall motion disturbances in this case, as well as conflicting views in the literature, raises the question whether postbiopsy coronary fistulas in transplant patients should be closed.
authors.affiliation: Department of Cardiology, University of Graz, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Gasser
authors.forename: H
authors.initials: H
authors.lastname: Koppel
authors.forename: O
authors.initials: O
authors.lastname: Luha
authors.forename: H
authors.initials: H
authors.lastname: Brussee
authors.forename: K
authors.initials: K
authors.lastname: Stoschitzky
authors.forename: K H
authors.initials: KH
authors.lastname: Tscheliessnigg
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004070:Digitalis / Q000627:therapeutic use; D004452:Echocardiography; D005500:Follow-Up Studies; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology; D016027:Heart Transplantation; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal; D010947:Plants, Toxic; D011183:Postoperative Complications; D016157:Vascular Fistula / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology; D016278:Ventricular Function, Right
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors