title: The science of bonding: from first to sixth generation.
abstract: BACKGROUND
  Adhesive dentistry has revolutionized restorative dental practice during the past 30 years. Improved adhesive materials have made resin-based composite restorations more reliable and long-standing.
  
  
  CONCLUSIONS
  This article reviews the evolution of bonding from the first generation to current bonding materials. It discusses the composition and effectiveness of the various iterations. Current products are highlighted to improve clinical use and performance of the materials.
authors.affiliation: Tufts University School of Dental Medicine, Boston, Mass. 02111, USA.
authors.forename: G
authors.initials: G
authors.lastname: Kugel
authors.forename: M
authors.initials: M
authors.lastname: Ferrari
mesh_terms: D000269:Adhesives / Q000737:chemistry / Q000145:classification*; D003188:Composite Resins / Q000737:chemistry / Q000145:classification; D001840:Dental Bonding / Q000145:classification* / Q000379:methods; D003743:Dental Enamel / Q000648:ultrastructure; D003764:Dental Materials / Q000737:chemistry / Q000145:classification*; D003793:Dental Restoration, Permanent / Q000379:methods; D017220:Dentin-Bonding Agents / Q000737:chemistry / Q000145:classification; D006801:Humans
chemical_list: D000269:Adhesives; D003188:Composite Resins; D003764:Dental Materials; D017220:Dentin-Bonding Agents