title: Non-electrostatic complexes with DNA: towards novel synthetic gene delivery systems.
abstract: We have developed new DNA complexing amphiphile based on Hoechst 33258 interaction with DNA grooves. The synthesis and physicochemical characterisation of lipid/DNA complexes, as compared to that of classical lipopolyamine for gene delivery, are described and discussed.
authors.affiliation: UMR-7001 ENSCP/CNRS/Aventis Pharma Gencell, Vitry sur Seine, France.
authors.forename: J
authors.initials: J
authors.lastname: Soto
authors.forename: M
authors.initials: M
authors.lastname: Bessodes
authors.forename: B
authors.initials: B
authors.lastname: Pitard
authors.forename: P
authors.initials: P
authors.lastname: Mailhe
authors.forename: D
authors.initials: D
authors.lastname: Scherman
authors.forename: G
authors.initials: G
authors.lastname: Byk
mesh_terms: D006690:Bisbenzimidazole / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D004996:Ethidium / Q000737:chemistry; D005456:Fluorescent Dyes; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D006860:Hydrogen Bonding; D008055:Lipids; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005456:Fluorescent Dyes; D008055:Lipids; D000644:Quaternary Ammonium Compounds; D004247:DNA; D004996:Ethidium; D006690:Bisbenzimidazole