title: Preoperative endoscopic ultrasonography in patients with gastric cancer.
abstract: OBJECTIVE
  There is a need to assess the accuracy of endoscopic ultrasonography (EUS) in the diagnosis and staging of gastric cancer, especially in the early and very advanced stages of the disease when the therapeutic approach is still controversial.
  
  
  METHODS
  A retrospective study was performed on 79 patients with gastric cancer in order to compare the stage defined by preoperative EUS with that assessed histopathologically. All patients underwent laparotomy for final diagnosis, staging, and eventually treatment. The results of EUS were correlated with the histologic findings of the resected specimens.
  
  
  RESULTS
  In the uT1 group, which corresponds to early gastric cancer, the diagnosis was histologically confirmed in 85.7% of the cases. In patients with advanced tumors defined as uT3-uT4, i.e., tumors infiltrating the serosa or neighboring structures, the diagnostic concordance was 91.1%. In contrast, concordance for less advanced lesions confined to the muscular layer was only 31.2%. As regards the lymph nodes, they were defined metastatic in 31 patients and confirmed to be histologically involved in 77.4%. In contrast, when the lymph nodes were assessed as negative at EUS, they proved to be metastatic in more than half the cases.
  
  
  CONCLUSIONS
  From the data it appears that EUS has proven to be valuable in correctly staging most of the patients. EUS shows not only tumor depth and local spread but also the passage from a pathologic to a normal wall and lymph node metastasis. EUS appears to represent an important advance in the staging and follow-up of patients with gastric cancer. Instruments and techniques will continue to evolve, but the next level of research should be designed to show that the improved staging provided by EUS has clinical utility and can affect patient outcome. It is noteworthy that the highest accuracy of EUS has been shown in those conditions (uT1 and uT3-4) which currently are under consideration for a therapeutic approach that differs from the standard one.
authors.affiliation: Centro Riferimento Oncologico della Basilicata, Rionero in Vulture PZ, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Mancino
authors.forename: F
authors.initials: F
authors.lastname: Bozzetti
authors.forename: A
authors.initials: A
authors.lastname: Schicchi
authors.forename: M
authors.initials: M
authors.lastname: Schiavo
authors.forename: P
authors.initials: P
authors.lastname: Spinelli
authors.forename: S
authors.initials: S
authors.lastname: Andreola
mesh_terms: D005260:Female; D005743:Gastrectomy / Q000379:methods; D005773:Gastroscopy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D014463:Ultrasonography / Q000379:methods