title: [Analysis of peculiarities in nucleotides disposition in the origin of chromosome replication-oriC from Escherichia coli].
abstract: Along with symmetrical features (palindromes, direct and inverted repeats), periodicities in the disposition of nucleotides in the origin of chromosome replication oriC from E. coli were studied by means of Fourier analysis. Peaks corresponding to the periods T = 2, 17, 95-100 nucleotides are the highest in the Fourier spectrum of oriC. Peaks corresponding to the periods T = 3, 11, 19, 13, 24, 27, 28, 41, 79-81 nucleotides are also prominent, but not so high. Thus, the main periodicities of the oriC spectrum of are not multiple of the B-DNA sugar-phosphate backbone period, which destabilize DNA at oriC and contributes to the spontaneous unwinding of DNA. The differences between the Fourier spectrum of oriC and those of regions adjacent to oriC are demonstrated.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: N G
authors.initials: NG
authors.lastname: Esipova
authors.forename: G I
authors.initials: GI
authors.lastname: Kutuzova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Makeev
authors.forename: G K
authors.initials: GK
authors.lastname: Frank
authors.forename: A V
authors.initials: AV
authors.lastname: Balandina
authors.forename: D E
authors.initials: DE
authors.lastname: Kamashev
authors.forename: V L
authors.initials: VL
authors.lastname: Karpov
mesh_terms: D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics*; D009711:Nucleotides / Q000737:chemistry / Q000235:genetics; D018741:Replication Origin / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D004269:DNA, Bacterial; D009711:Nucleotides
vernacular_title: Analiz osobennosteĭ raspredeleniia nukleotidov na uchastke nachala replikatsii khromosomy-oriC iz Escherichia coli.