Electrochemotherapy with bleomycin in the treatment of hypernephroma metastasis: case report and literature review.
A metastasis of hypernephroma was treated by electrochemotherapy with bleomycin. Electrochemotherapy consists of chemotherapy followed by local application of electric pulses to the tumor in order to increase drug delivery to the cells. In the course of a four-week treatment period, the subcutaneous metastasis of the hypernephroma was treated with three sessions of electrochemotherapy, each consisting of 9-10 runs of 8 electric pulses, 10 min after intravenous injection of bleomycin. This treatment resulted in stabilization of the tumor volume for 12 months, whereas the subcutaneous metastasis next to the electrochemotherapy-treated one that did not receive electric pulses progressed immediately.
Sersa
G
G
Institute of Oncology, Ljubljana, Slovenia. gsersa@onko-i.si
Cufer
T
T
Cemazar
M
M
Rebersek
M
M
Zvonimir
R
R
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary* / Q000601:surgery; D016503:Drug Delivery Systems; D004560:Electricity; D017809:Fatal Outcome; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000556:secondary*
D000903:Antibiotics, Antineoplastic; D000964:Antimetabolites, Antineoplastic; D001761:Bleomycin