title: [A senile case of acute necrotizing myopathy presenting prolonged severe muscle paralysis due to high dose glucocorticoid and muscle relaxant].
abstract: An 82-year old man was admitted with dyspnea, productive cough and wheezing. In addition to antibiotics (meropenem trihydrate 0.5 g/day), glucocorticoids (hydrocortisone 1.250 mg, methylpredonisolone 4.250 mg) were administered for the severe bronchospasms. Since his respiratory condition deteriorated, he underwent mechanical ventilation using a muscle relaxant (vecuronium bromide, total dose 776 mg) in combination with high dose glucocorticoid. As his pneumonia improved on the 10th hospital day, we started weaning him from the ventilator. However, we were unable to complete weaning from the ventilator because of prolonged quadriplegia and paralysis of the respiratory muscles. A few days later, myoglobinuria appeared. Electrophysiological examinations suggested the involvement of both neuromuscular junctions and muscles. Muscle biopsy showed rhabdomyolysis. Acute necrotizing myopathy was diagnosed due to high doses of glucocorticoid, muscle relaxant, or both. He required about 3 months to be weaned from the mechanical ventilation, and another 3 months to leave the hospital. Based on our experience, we should consider acute myopathy as an adverse effect of glucocorticoids, muscle relaxants or both in elderly patients who require mechanical ventilation.
authors.affiliation: Department of Respiratory Medicine and Neurology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Okuma
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: K
authors.initials: K
authors.lastname: Noto
authors.forename: M
authors.initials: M
authors.lastname: Katae
authors.forename: T
authors.initials: T
authors.lastname: Dambara
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuchi
mesh_terms: D000208:Acute Disease; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects*; D011014:Pneumonia / Q000628:therapy; D011782:Quadriplegia / Q000139:chemically induced*; D012121:Respiration, Artificial; D012133:Respiratory Paralysis / Q000139:chemically induced; D012206:Rhabdomyolysis / Q000139:chemically induced*; D016896:Treatment Outcome; D014673:Vecuronium Bromide / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D003473:Neuromuscular Nondepolarizing Agents; D014673:Vecuronium Bromide; D006854:Hydrocortisone; D008775:Methylprednisolone