title: [Immunoallergic reactions of drug origin: epidemiologic and clinical data].
abstract: Allergic and pseudoallergic reactions frequently occur in hospitalized patients and represent up to one-third of adverse drug reactions. Allergic reactions are unpredictable reactions, related to immunologic mechanisms. Pseudoallergic reactions mimic allergic reactions but no drug-specific antibody or T-cell proliferation can be demonstrated. Clinical presentations are numerous and heterogeneous, from a mild urticaria to a dramatic anaphylactic shock and an extensive bullous skin disease. A true diagnosis is rarely set up and the tools for it are lacking. In this review, we will focus on some epidemiological data concerning these reactions, including data on incidence, mortality and cost.
authors.affiliation: Clinique des Maladies Respiratoires, INSERM U454, IFR3, Hôpital Arnaud de Villeneuve, Montpellier, France.
authors.forename: P
authors.initials: P
authors.lastname: Demoly
authors.forename: D
authors.initials: D
authors.lastname: Messaad
authors.forename: S
authors.initials: S
authors.lastname: Benahmed
authors.forename: D
authors.initials: D
authors.lastname: Hillaire-Buys
authors.forename: J P
authors.initials: JP
authors.lastname: Blayac
authors.forename: P
authors.initials: P
authors.lastname: Godard
authors.forename: F B
authors.initials: FB
authors.lastname: Michel
authors.forename: J
authors.initials: J
authors.lastname: Bousquet
mesh_terms: D000818:Animals; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans
vernacular_title: Les réactions immuno-allergiques d'origine médicamenteuse: données épidémiologiques et cliniques.