title: The basal SAR of a novel insulin receptor activator.
abstract: The synthesis and SAR of analogues prepared from novel insulin receptor activator 1 are described. Changes to the dihydroxyquinone core were not tolerated while functionalization of the two indoles contained in 1 resulted in little effect upon activation of the insulin receptor.
authors.affiliation: Basic Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA. blair_wood@merck.com
authors.forename: H B
authors.initials: HB
authors.lastname: Wood
authors.forename: R
authors.initials: R
authors.lastname: Black
authors.forename: G
authors.initials: G
authors.lastname: Salituro
authors.forename: D
authors.initials: D
authors.lastname: Szalkowski
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: D E
authors.initials: DE
authors.lastname: Moller
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.forename: A B
authors.initials: AB
authors.lastname: Jones
mesh_terms: D011972:Receptor, Insulin / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D011972:Receptor, Insulin