New NO donors with antithrombotic and vasodilating activities, Part 29. N-(1-cyanocyclohexyl)-C-phenylnitrones and glyoxaldinitrones.
Six N-(1-cyanocyclohexyl)-C-phenylnitrones 4a-f (4b-f for the first time) and 22 glyoxaldinitrones 7a-v were prepared and tested for antithrombotic (p.o. administration to rats, 60 mg/kg) effects. Both classes of compounds exhibit considerable antithrombotic activities. Maximum inhibition of thrombus formation in arterioles (21%) was observed in N,N'-bis-2-phenylethylglyoxaldinitrone (7o) and N,N'-bis-4-nitrobenzylglyoxaldinitrone (7u). The compounds form only small amounts of nitric oxide in vitro by the addition of a Fe(3+)-porphyrine complex and an oxygen donor.
Camehn
R
R
Institut für Pharmazie, Freie Universität Berlin, Germany.
Rehse
K
K
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D003510:Cyclohexanes / Q000138:chemical synthesis*; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006037:Glyoxal / Q000031:analogs & derivatives*; D007834:Lasers; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000494:pharmacology; D009589:Nitrogen Oxides / Q000138:chemical synthesis*; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000494:pharmacology
D003510:Cyclohexanes; D005343:Fibrinolytic Agents; D020030:Nitric Oxide Donors; D009589:Nitrogen Oxides; D014665:Vasodilator Agents; C015388:nitrones; D006037:Glyoxal; D001241:Aspirin