Hydrodynamic modelling of stress.
This work is a qualitative study of an organism's physiological adaptative response to stress. The experimental data were selected from a previous study leading to the conclusion that stress may be considered as a topological retraction within a vital space that must be more precisely defined. The experimental methodology uses rat poisoning by neurotoxins. The control parameter is the intensity of the toxic doses. Measured parameters are the animals' survival rate and the kinetics of cerebral acetylcholinesterase activity. The results, when expressed as a function of the inverted doses, show a characteristic evolution. The pattern of the curve closely resembles a vortex profile. This analogy is studied more extensively in both the physical and biological domains. These findings help to clarify the concept of biological stress which presents the same vectorial properties as hydrodynamic vorticity. In particular, the dissipation of stress and the dissipation of vorticity seem to obey the same laws. This observation is valid for both diffusion and convection processes. The decompensation phase of stress could be compared with the instability and turbulence in flows. Our approach in this paper is mainly to establish a general and phenomenological description of the stress response fitting experimental observations.
Viret
J
J
CRSSA, La Tronche, France.
Grimaud
L
L
Jimenez
J
J
D000110:Acetylcholinesterase / Q000378:metabolism; D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008962:Models, Theoretical; D009498:Neurotoxins / Q000633:toxicity; D011041:Poisoning / Q000503:physiopathology; D051381:Rats; D013312:Stress, Physiological / Q000150:complications / Q000503:physiopathology*
D009498:Neurotoxins; D000110:Acetylcholinesterase