title: Plasma-circulating levels of natriuretic peptides in patients with bone and soft tissue injuries.
abstract: To evaluate the release and possible role of N-terminal end of atrial natriuretic factor (ANF) prohormone (proANF-1-30) and C-terminal end of ANF prohormone (aANP-1-28) in patients with soft tissue and bone injuries, 20 patients with soft tissue injuries, 18 bone-fractured patients, and 21 healthy controls were examined. Samples were collected from patients within 24 h after injury. Plasma level of proANF-1-30 and aANP-1-28 were higher in orthopedic patients than the soft tissue injury patients compared to controls (P < 0.005, P<0.05, respectively). proANF-1-30 was over 15-fold greater than aANP-1-28 in the healthy control samples. These data hypothesized that the concentration of proANF-1-30 may be related to tissue damages in man.
authors.affiliation: The University of Birmingham, Department of Surgery, BT15 2TT, Birmingham, United Kingdom.
authors.forename: G N
authors.initials: GN
authors.lastname: Onuoha
authors.forename: E K
authors.initials: EK
authors.lastname: Alpar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000276:immunology; D001842:Bone and Bones / Q000293:injuries*; D003238:Connective Tissue / Q000293:injuries*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014947:Wounds and Injuries / Q000097:blood
chemical_list: D009320:Atrial Natriuretic Factor