title: Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists.
abstract: Quinazolin-4-one derivatives of methaqualone substituted at C-2 define a new class of noncompetitive antagonists at AMPA receptors.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, CT 06340, USA. chenab@pfizer.com
authors.forename: B L
authors.initials: BL
authors.lastname: Chenard
authors.forename: F S
authors.initials: FS
authors.lastname: Menniti
authors.forename: M J
authors.initials: MJ
authors.lastname: Pagnozzi
authors.forename: K D
authors.initials: KD
authors.lastname: Shenk
authors.forename: F E
authors.initials: FE
authors.lastname: Ewing
authors.forename: W M
authors.initials: WM
authors.lastname: Welch
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000187:drug effects / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology; D008702:Methaqualone / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D008702:Methaqualone