Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.
We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.
Dolara
P
P
Corte
B
B
Ghelardini
C
C
Pugliese
A M
AM
Cerbai
E
E
Menichetti
S
S
Lo Nostro
A
A
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry*
D000777:Anesthetics; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012717:Sesquiterpenes; D013729:Terpenes; C014119:myrrh oil