Studies of ion-exchange resin complex of chloroquine phosphate.
High-potency adsorbates of chloroquine phosphate (CQP) were prepared by the batch method using a polyacrylic acid ion-exchange resin. Taste evaluation of the adsorbates shows significant masking of the bitterness of the drug. The complex formation was complete at pH 6.0. Stability studies at 37 degrees C, 45 degrees C, and 60 degrees C indicated that the complex was stable at all conditions for 1 month. In vitro release studies revealed complete drug elution from the complex at pH 1.2 and 2.0.
Agarwal
R
R
Panacea Biotec Limited, Punjab, India.
Mittal
R
R
Singh
A
A
D000180:Acrylic Resins; D000284:Administration, Oral; D000962:Antimalarials / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002738:Chloroquine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins; D013649:Taste
D000180:Acrylic Resins; D000962:Antimalarials; D007475:Ion Exchange Resins; C006903:carbopol 940; C023676:chloroquine diphosphate; D002738:Chloroquine