A role for epithelial gammadelta T cells in tissue repair.
My colleagues and I have a long-term interest in interactions between intraepithelial gammadelta T cells and neighboring epithelial cells. We have focused our studies on interactions in the thymus, skin, and intestine, and are investigating the development, specificity, and function of these gammadelta T cells. Our results have defined unique properties of these cells and support a specialized role for epithelial gammadelta T cells in immune surveillance, wound repair, inflammation, and protection from malignancy.
Havran
W L
WL
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. havran@scripps.edu
D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D004847:Epithelial Cells / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000473:pathology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D012038:Regeneration; D012867:Skin / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology; D014945:Wound Healing
D016692:Receptors, Antigen, T-Cell, gamma-delta