title: Optimization and evaluation of the signal intensity change in multisection oxygen-enhanced MR lung imaging.
abstract: The behavior of the signal intensity in MRI of human lungs was investigated during inhalation of pure oxygen. Nine volunteers were examined, five using a breath-hold and four using a non-breath-hold technique. Four coronal slices were acquired in each volunteer using an inversion recovery turbo spin-echo sequence. The inversion time of the sequence was optimized for maximum contrast. Breathing of pure oxygen and room air was alternated in the volunteers. Breath-hold and non-breath-hold cases were compared. Breathing pure oxygen lead to a statistically significant signal intensity increase (up to 18%) compared to breathing room air. In addition, T(1) maps were acquired during breathing 100% oxygen and room air. Inhalation of pure oxygen reduced the mean T(1) time of the lungs from 1280 (+/-85) msec to 1224 (+/-139) msec without breath-hold and from 1219 (+/-176) to 1074 (+/-92) msec with breath-hold. Therefore, an optimized sequence and measurement protocol provided significant signal intensity changes utilizing 100% oxygen. Magn Reson Med 43:860-866, 2000.
authors.affiliation: Department of Diagnostic Radiology, Klinikum Grosshadern, University of Munich, Munich, Germany. ralf.loeffler@med.siemens.de
authors.forename: R
authors.initials: R
authors.lastname: Löffler
authors.forename: C J
authors.initials: CJ
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Peller
authors.forename: H
authors.initials: H
authors.lastname: Penzkofer
authors.forename: M
authors.initials: M
authors.lastname: Deimling
authors.forename: M
authors.initials: M
authors.lastname: Schwaiblmair
authors.forename: J
authors.initials: J
authors.lastname: Scheidler
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010100:Oxygen / Q000008:administration & dosage*; D010101:Oxygen Consumption; D012123:Pulmonary Ventilation; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D010100:Oxygen