[Dose-response relationship: relevance for medical practice].
Dose-finding studies are performed routinely in patients and--if appropriate surrogate models exist--also in healthy volunteers. Such studies aim at establishing the optimal dose range for further clinical studies on the efficacy and the risk-benefit ratio of a new drug. The dose-response relationship of a drug is most often described by a sigmoidal curve. Its parameters include the mean effective dose, the maximal effect and the steepness. Interpretation of such curves should be done in the context of the intended clinical indications of the drug. The risk-benefit ratio of a drug can be assessed by overlapping the dose-response curve of wanted and unwanted clinical effects, again, any overlapping (which can be described e.g. by the therapeutic index) should be seen in the context of the indication and available therapeutic alternatives.
Klinkhardt
U
U
Institut für Klinische Pharmakologie, Universitätsklinik Frankfurt am Main.
Harder
S
S
D016907:Adverse Drug Reaction Reporting Systems; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D016896:Treatment Outcome
D004364:Pharmaceutical Preparations
Dosis-Wirkungs-Beziehung: Relevanz für die ärztliche Praxis.