[Protein folding with molecular chaperones:stochastic process under control].
Protein folding in a living cell occurs with the participation of specialized proteins, molecular shaperons. The functional role and molecular mechanism of action of shaperons are discussed. It is shown that shaperons can be considered as proteins that, upon interaction with the folding peptide chain, transform the spontaneous folding to a process controlled and regulated by cellular factors. Models describing these controlled phenomena are discussed.
Demchenko
A P
AP
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine.
D000818:Animals; D006801:Humans; D008958:Models, Molecular; D018832:Molecular Chaperones / Q000737:chemistry*; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*; D013269:Stochastic Processes
D018832:Molecular Chaperones; D011506:Proteins
Folding belka s molekuliarnymi shaperonami:stakhasticheskiĭ protsess pod kontrolem.