Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects.
Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.
Jander
G
G
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Rahme
L G
LG
Ausubel
F M
FM
D000818:Animals; D001681:Biological Assay; D006801:Humans; D051379:Mice; D009036:Moths / Q000382:microbiology*; D016296:Mutagenesis; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence