title: Decreased activity of hepatic alkaline protease in rats with carbon tetrachloride-induced liver cirrhosis.
abstract: To investigate the cause of accumulation of oxidised proteins in the livers of rats with carbon tetrachloride (CCl4) induced liver cirrhosis, the activity of alkaline protease (a high molecular weight, multisubunit cysteine proteinase) was determined in the cirrhotic livers. A significant decrease (P < 0.05) in the activity of hepatic alkaline protease was observed in the cirrhotic rats. Decreased activity of alkaline protease in the liver of cirrhotic rats may contribute to the accumulation of the oxidised proteins in the liver.
authors.affiliation: Department of Biochemistry, Christian Medical College, Vellore, India.
authors.forename: P
authors.initials: P
authors.lastname: Abraham
authors.forename: G
authors.initials: G
authors.lastname: Wilfred
authors.forename: B
authors.initials: B
authors.lastname: Ramakrishna
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology* / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000201:enzymology* / Q000473:pathology; D008297:Male; D010084:Oxidation-Reduction; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D011506:Proteins; D002251:Carbon Tetrachloride