[The antimicrobial activity of nitric oxide and its role in the infectious process].
In this article information on an important role of nitric oxide (NO) in inhibiting the growth of a number of pathogenic microorganisms, including intracellular parasites, and their elimination from the host body is presented. Differences between the mechanisms of the production of NO and free-radical compounds having antimicrobial action are given. The regulation of the activity of constitutive NO-synthase and inducible NO-synthase and the relationship between the latter and the phagocytic activity and production of anti-inflammatory cytokines are described. An important role of NO in the development of the nonspecific resistance of the body is mentioned.
Bondarenko
V M
VM
Gamaleya Research Institute of Epidemiology and Microbiology, Moscow, Russia.
Vinogradov
N A
NA
Maleev
V V
VV
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001424:Bacterial Infections / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D007113:Immunity, Innate / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D009569:Nitric Oxide / Q000494:pharmacology* / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000502:physiology; D011528:Protozoan Infections / Q000276:immunology / Q000469:parasitology / Q000503:physiopathology*
D000890:Anti-Infective Agents; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase
Antimikrobnaia aktivnost' okisi azota i ee rol' v infektsionnom protsesse.