Test for fused-cell origin of tumors with Mus caroli carrying glucose-6-phosphate dehydrogenase cellular mosaicism.
A test system for examining the fused cell-origin of tumors was developed by application of Mus caroli carrying the X-chromosome inactivation cellular mosaicism for G6PD. A G6PD heterodimer pattern is expected if a tumor is initiated from a fused cell. Among tumors induced by subcutaneous injection of a high dose of MCA, three tumors exhibited a single G6PD phenotype and one tumor exhibited a multiple G6PD phenotype; however, the G6PD heterodimer pattern was not found. Although the results obtained were not conclusive, this system is thought to be useful for detecting a possible fused cell-origin of tumors.
Tanaka
K
K
Radiobiology Division, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan.
Ootsuyama
A
A
Tanooka
H
H
Ansell
J D
JD
D000818:Animals; D019281:Dimerization; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006579:Heterozygote; D008113:Liver Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000235:genetics*; D008748:Methylcholanthrene; D051379:Mice; D009030:Mosaicism; D014960:X Chromosome
D008748:Methylcholanthrene; D005954:Glucosephosphate Dehydrogenase