[Development of a new method for preparing biologically active compounds based on the typed strain Streptomyces werraensis].
The regulatory function of a DNA fragment responsible for actinomycin resistance in the typed strain Streptomyces werraensis ATCC 1365, which produces a macrotetrolide antibiotic, was studied. Metabolic changes made this strain capable of producing an antibiotic complex, which comprises four biologically active compounds absent from the parent culture.
Rusanova
E P
EP
Lomonosov Moscow State University, Russia.
Alekhov
T A
TA
Fedorova
G B
GB
Katrukha
G S
GS
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D015373:Bacterial Typing Techniques; D004269:DNA, Bacterial / Q000235:genetics; D003609:Dactinomycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D018942:Macrolides; D013302:Streptomyces / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D018942:Macrolides; D003609:Dactinomycin
Razrabotka novogo metoda polucheniia biologicheski aktivnykh soedineniĭ na osnove tipovogo shtamma Streptomyces werraensis.