title: [P185 (Neu) oncoprotein in the prognosis of bladder carcinoma. Experience of 5 years].
abstract: OBJECTIVE
  To determine the utility of p185 oncogene in the biological characterization of transitional cell carcinoma and in the prediction of recurrence, and to analyze survival at 5 years mean follow-up.
  
  
  METHODS
  A prospective clinical cohort study was conducted on 81 patients. Tissue specimens were obtained between November 1992 and November 1993. The study comprised two groups: nontumoral bladder tissue specimens from 20 patients (group I) and tissue specimens from 61 patients with bladder carcinoma (group II). p185 expression was determined by enzyme immunoanalysis (EIA). A statistical analysis of the results was performed.
  
  
  RESULTS
  p185 oncoprotein levels were higher in patients with recurrence (1098.97 HNU/mg protein vs. 924.54 HNU/mg). Although higher levels of p185 were found in the patients that had died vs those who are alive, the differences were not statistically significant for overall survival or stratification by tumor grade or infiltration (p = 0.556; ns).
  
  
  CONCLUSIONS
  Determination of p185 oncoprotein was found to be useful in the prediction of tumor recurrence at 5 years mean follow-up.
authors.forename: J
authors.initials: J
authors.lastname: Moreno Sierra
authors.forename: M L
authors.initials: ML
authors.lastname: Maestro de las Casas
authors.forename: E
authors.initials: E
authors.lastname: Redondo González
authors.forename: C
authors.initials: C
authors.lastname: Fernández Pérez
authors.forename: V
authors.initials: V
authors.lastname: del Barco Barriuso
authors.forename: M T
authors.initials: MT
authors.lastname: Sanz Casla
authors.forename: E
authors.initials: E
authors.lastname: Blanco Jiménez
authors.forename: A
authors.initials: A
authors.lastname: Silmi Moyano
authors.forename: L
authors.initials: L
authors.lastname: Resel Estévez
mesh_terms: D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000401:mortality*
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases
vernacular_title: Oncoproteína P185 (Neu) en el pronóstico del carcinoma vesical. Experiencia a 5 años.