Transport between ER and Golgi.
In the last eighteen months, it has become clear that some classes of proteins are actively recruited into endoplasmic reticulum export carriers, whereas others are exported as bulk-flow cargo. Subsequent transport to the Golgi is mediated by tubulovesicular membranes. The anterograde membrane flow is compensated for by a retrograde pathway, which, in addition to the recycling of membrane and proteins to the endoplasmic reticulum, may play a role in anterograde cargo concentration.
Klumperman
J
J
Department of Cell Biology, Institute of Biomembranes, Center for Biomedical Genetics, University Medical Center, Utrecht, 3584 CX, The Netherlands. J.Klumperman@lab.azu.nl.
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D020755:Coat Protein Complex I / Q000378:metabolism; D018699:Coated Vesicles / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D012995:Solubility; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D020755:Coat Protein Complex I; D010750:Phosphoproteins; C106113:SEC31 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins