Bone metabolism: newer perspectives.
The general perception of bone is that of an inert material which provides the framework (skeleton) to support the rest of the body and organs. This concept is totally inaccurate. Bone is in fact a vital organ of the body. Structural stability only happens to be one of its many important functions. Bone is a dynamic connective tissue. Among the functions of bone are: (1) support of mechanical loads, (2) protection of vital organ, (3) haematopoiesis, (4) ionized mineral homeostasis, (5) regulation of tissue development, remodeling and repair through the synthesis of paracrine and autocrine factors, and (6) electrical capacitors. Cellular interaction between the 3 cell types and hormonal, physical and chemical signals controls bone health. The osteoblasts appear to communicate with the osteocytes and osteoclasts both directly and indirectly and coordinates cell activity. Mineral metabolism is a well recognised function of bone. However bone biomechanics and electrical function are little appreciated activities of bone.
Ghani
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AN
Ampang Putri Specialist Hospital, Kuala Lumpur.
D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology