title: Mitochondrial-nuclear crosstalk is involved in oxygen-regulated gene expression in yeast.
abstract: The expression of several oxygen-regulated nuclear genes in the yeast Saccharomyces cerevisiae is affected by the mitochondrion. Recent evidence suggests two levels of mitochondrial involvement. On the one hand, mitochondrial respiratory function is essential for the anoxic induction of some hypoxic genes. On the other hand, the mitochondrial genome itself functions independently of its respiratory function, in the optimal expression of some aerobic genes. These findings suggest that the mitochondrion release at least two types of 'signals' that function in the expression of oxygen-regulated genes.
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309, USA.
authors.forename: R O
authors.initials: RO
authors.lastname: Poyton
authors.forename: C J
authors.initials: CJ
authors.lastname: Dagsgaard
mesh_terms: D000332:Aerobiosis / Q000235:genetics / Q000502:physiology; D000693:Anaerobiosis / Q000235:genetics / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*
chemical_list: D003576:Electron Transport Complex IV; D010100:Oxygen