[Analysis of the 32 bp deletion in the CCR5 chemokine receptor gene in people from Moscow, infected with HIV-1].
Chemokine receptors have recently been shown to mediate HIV-1 entry into cells. The chemokine receptor CCR5 plays a key role in this process. A 32-bp deletion within the coding region of the CCR5 gene generates a truncated nonfunctional receptor. In HIV-1-infected individuals homozygous for this mutation, disease progression is inhibited. We analyzed the frequencies of the deletion in HIV-1-infected seropositive individuals. No significant differences in allelic frequencies of the CCR5 gene between the control and general HIV-1-infected cohorts and within the latter group between the infected individuals and patients with AIDS symptoms were revealed.
Shadrina
M I
MI
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
Kapylov
V M
VM
Miloserdova
O V
OV
Slominskiĭ
P A
PA
Limborskaia
S A
SA
D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000302:isolation & purification; D006720:Homozygote; D006801:Humans; D009031:Moscow / Q000453:epidemiology; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion
D019713:Receptors, CCR5
Analiz deletsii 21 pn v gene retseptora khemokinov CCR5 u lits, infitsirovannykh VICh-1, iz g. Moskvy.