Reticulate acropigmentation of Dohi: a case report of autosomal recessive inheritance.
Reticulate acropigmentation of Dohi is a rare dyschromic disorder that generally has an autosomal dominant pattern of inheritance. Most of the cases have primarily been described from Japan. Only a few similar cases have been described elsewhere. We describe 3 black siblings, one boy and two girls, who had progressive reticulate hyperpigmented and hypopigmented macules over the dorsa of hands and feet, which began in early childhood. There were no palmar pits or breaks of the epidermal rete ridge pattern nor was there a family history of any pigmentary skin diseases. Three skin biopsies were performed on one patient; a biopsy specimen from a hyperpigmented macule showed increased melanin in all epidermal levels tapering towards the surface, a second biopsy specimen from a hypopigmented macule showed much less melanin, but it had a similar distribution. A third specimen from a hyperpigmented macule for electron microscopy showed a moderate number of stage III and IV melanosomes in the cytoplasm of the melanocytes. To our knowledge, these patients are the first cases reported from the Middle East with an autosomal recessive pattern of inheritance, confirming previous reports.
Alfadley
A
A
Departments of Medicine and Pathology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudia Arabia.
Al Ajlan
A
A
Hainau
B
B
Pedersen
K T
KT
Al Hoqail
I
I
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000235:genetics* / Q000473:pathology; D017496:Hypopigmentation / Q000235:genetics* / Q000473:pathology; D008297:Male; D010375:Pedigree