title: Prevalence of hepatitis-G virus and hepatitis-C virus infection in patients with non-Hodgkin's lymphoma.
abstract: Several studies have reported that hepatitis-C virus may have a role in the development of non- Hodgkin's lymphoma. Hepatitis-G virus has hepatitis-C virus like characteristics. The possible association between hepatitis-G virus infection and non-Hodgkin's lymphoma is not clear. The aim of this study was to determine the prevalence of hepatitis-G virus and hepatitis-C virus infection in patients with non-Hodgkin's lymphoma without blood transfusion. Forty-four patients with non-Hodgkin's lymphoma were enrolled in the study. Serum samples derived from the patients were tested for antibodies against hepatitis-C virus by ELISA. Hepatitis-G virus and hepatitis-C virus RNA were detected by reverse transcription-polymerase chain reaction. Only two of 44 patients (5%) with non-Hodgkin's lymphoma were positive for Anti- HCV and hepatitis C virus RNA. One patient had low grade non-Hodgkin's lymphoma with follicular mixed histopathology while the other had intermediate grade with diffuse large cell histopathology. Hepatitis-G virus infection was detected in none of the patients. We concluded that hepatitis-G virus does not seem to be in association with non-Hodgkin's lymphoma.
authors.affiliation: Department of Medical Oncology, Başkent University Faculty of Medicine, 06490 Ankara, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Arican
authors.forename: T
authors.initials: T
authors.lastname: Sengezer
authors.forename: M
authors.initials: M
authors.lastname: Bozdayi
authors.forename: H
authors.initials: H
authors.lastname: Bozkaya
authors.forename: E
authors.initials: E
authors.lastname: Uçgül
authors.forename: D
authors.initials: D
authors.lastname: Dinçol
authors.forename: O
authors.initials: O
authors.lastname: Uzunalimoğlu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D018067:Flaviviridae; D006526:Hepatitis C / Q000453:epidemiology*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis
chemical_list: D012367:RNA, Viral