[Effect of the mutation process on formation of alkaloids in Penicillium roquefortii BKM F-141 and P. fellutanum BKM F-1073].
Mutant strains of Penicillium roquefortii VKM F-141 and P. Fellutanum VKM F-1073 were obtained by mutagenesis induced by ultraviolet irradiation, N-methyl-N-nitronitrosoguanidine and bromouracil. By the rates of alkaloid production, the mutant strains can be divided into three groups: 1) unable to synthesize alkaloids; 2) with a high rate of biosynthesis; 3) with changed alkaloid composition. Compounds not characteristic of wild-type cultures were found in alkaloid fractions of some mutant strains.
Buzilova
I G
IG
G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
Boĭchenko
D M
DM
Boĭchenko
L V
LV
Zelenkova
N F
NF
Arinbasarov
M U
MU
Baskunov
B P
BP
Reshetilova
T A
TA
D000470:Alkaloids / Q000096:biosynthesis*; D001976:Bromouracil / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D016296:Mutagenesis; D009154:Mutation; D010407:Penicillium / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D013045:Species Specificity; D014466:Ultraviolet Rays
D000470:Alkaloids; D008769:Methylnitronitrosoguanidine; D001976:Bromouracil
Vliianie mutatsionnogo protsessa na obrazovanie alkaloidov u Penicillium roquefortii BKM F-141 i P. fellutanum BKM F-1073.