[Changes of collagenase activity in immune hepatic fibrosis following pig's serum injection and therapeutic effect of HanDanGanLe].
OBJECTIVE
To investigate the changes of collagenase activity in immune hepatic fibrosis following pig's serum injection and the therapeutic effect of HanDanGanLe.


METHODS
Pig's serum was injected intraperitoneally to Wistar rats to duplicate the hepatic fibrosis model due to immunologic injury. HanDanGanLe was used as therapeutic medicine and colchicine as control. The animals were killed at 12th week to detect hepatic collagenase activity, the staining semiquantity of hepatic collagenous fibre, and the content of hepatic collagen.


RESULTS
HanDanGanLe can increase collagenase activity, decrease the content of collagenous fibre and collagen in the liver. The beneficial effect achieved in HanDanGanLe-treatment group especially in high-dose group in comparison to colchicine-treatment group.


CONCLUSIONS
HanDanGanLe can effectively increase collagenase activity, improve collagen degradation, and abate hepatic fibrosis.
Lu
Y
Y
Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.
Lu
T
T
Cheng
M
M
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D003094:Collagen / Q000378:metabolism; D017364:Collagenases / Q000378:metabolism*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology* / Q000209:etiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013552:Swine
D004365:Drugs, Chinese Herbal; D003094:Collagen; D017364:Collagenases; D003078:Colchicine