Clinical response to gold as a circulating contact allergen.
In order to study the flare-up of contact allergy, 35 patients with a contact allergy to gold were given an intramuscular injection of 10 mg gold sodium thiomalate, i.e. the anti-rheumatic drug Myocrisin. Clinical reactions comprised an eczematous flare-up of previously positive patch tests to gold and of a previous dermatitis, which occurred in 80% and 26%, respectively; a toxicoderma-like rash in 46%; and a transient fever in 60%. With the antigen rapidly reaching the bloodstream, the technique provides an experimental human model for studying flare-up mechanisms in contact allergy.
Möller
H
H
Department of Dermatology, Lund University, Malmö University Hospital, Sweden. halvor.moller@derm.mas.lu.se
D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D004485:Eczema / Q000139:chemically induced; D005076:Exanthema / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000139:chemically induced; D012971:Gold Sodium Thiosulfate / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000175:diagnosis; D007273:Injections, Intramuscular; D008297:Male; D010328:Patch Tests; D012680:Sensitivity and Specificity
D012971:Gold Sodium Thiosulfate