[The use of insulin as carrier in targeted therapy].
Upon insulin binding to its receptor, the receptor-ligand complexes will be internalized into the target cell. The internalized insulin will leave the endosome and associate with the nuclear matrix. This process might be useful for targeted therapy. Some complex can link with the insulin be internalized into the target cell by insulin receptor-mediated endocytosis and enter the cell nuclei to cure some diseases.
Ou
X
X
Department of Nuclear Medicine, First Affiliated Hospital, West China University of Medicine Sciences, Chengdu.
Kuang
A
A
D002467:Cell Nucleus / Q000378:metabolism; D004337:Drug Carriers; D004705:Endocytosis; D018014:Gene Transfer Techniques; D007328:Insulin / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D011972:Receptor, Insulin / Q000378:metabolism*
D004337:Drug Carriers; D007328:Insulin; D011972:Receptor, Insulin