Is the 5-HT(1Dbeta) receptor gene implicated in the pathogenesis of obsessive-compulsive disorder?
OBJECTIVE
Obsessive-compulsive disorder (OCD) is a psychiatric condition for which strong evidence of a genetic component and serotonergic system involvement exists. Recent studies have shown that sumatriptan, a selective ligand of the serotonin (5-HT)(1Dbeta) autoreceptor, modifies OCD symptoms. The aim of this study was to investigate the presence of linkage disequilibrium between the 5-HT(1Dbeta) receptor gene, which has a variant caused by a silent G to C substitution at nucleotide 861 of the coding region, and OCD.


METHODS
DNA was collected from 67 probands who met DSM-IV criteria for OCD and from their living parents or siblings. Transmission Disequilibrium Test/sib-Transmission Disequilibrium Test analyses were then conducted with the DNA data.


RESULTS
Thirty-two families were informative for the analysis, which showed a preferential transmission of the G allele to the affected subjects.


CONCLUSIONS
If the results are confirmed, there may be important implications for the 5-HT(1Dbeta) receptor gene in the pathogenesis and treatment of OCD.
Mundo
E
E
Neurogenetics Section, University of Toronto, Ontario, Canada.
Richter
M A
MA
Sam
F
F
Macciardi
F
F
Kennedy
J L
JL
D000328:Adult; D017660:Autoreceptors / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy / Q000235:genetics*; D011110:Polymorphism, Genetic; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin / Q000187:drug effects / Q000235:genetics*; D018170:Sumatriptan / Q000494:pharmacology / Q000627:therapeutic use
D017660:Autoreceptors; D044302:Receptor, Serotonin, 5-HT1B; D011985:Receptors, Serotonin; D018170:Sumatriptan