[The effect of the amine salt of 2,4-dichlorophenoxyacetic acid on the cluster- and colony-forming capacity of the bone marrow and on the mononuclear phagocyte system].
In experiments on 124 noninbred white rats weighing 180-200 g the influence of the intragastric administration of amino of 2,4-dichlorophenoxyacetic acid in doses of 2.0 and 20 mg/kg daily on the characteristics of their mononuclear phagocyte system was studied. The study revealed a decrease in the number of monocytic precursors in the marrow, an increase in their capacity for colony formation, the inhibited cell function on the periphery of the system simultaneously with the enhancement of oxidizing processes. The metabolic activation of cells was accompanied by their functional insufficiency, which led to the activation of monocytopoiesis and the increased migration of monocytes to peripheral blood.
Imel'baeva
E A
EA
Bashkir State Medical University, Ufa, Russia.
Teplova
S N
SN
Kamilov
F Kh
FKh
Kaiumova
A F
AF
D015084:2,4-Dichlorophenoxyacetic Acid / Q000008:administration & dosage / Q000633:toxicity*; D000588:Amines / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D005260:Female; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D017737:Macrophages, Peritoneal / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats
D000588:Amines; D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid
Vliianie aminnoĭ soli 2,4-dikhlorfenoksiuksusnoĭ kisloty na klaster- i kolonieobrazuiushchuiu sposobnost' kostnogo mozga i sistemu mononuklearnykh fagotsitov.