title: Haemostasis in patients with Behçet's disease.
abstract: OBJECTIVE
  to determine whether Behçet's disease affects haemostatic function.
  
  
  METHODS
  University Hospital, Turkey.
  
  
  METHODS
  one hundred and twenty-seven consecutive patients with Behçet's disease, 34 of whom with a history of vascular involvement.
  
  
  METHODS
  prothrombin fragment 1+2 tissue plasminogen activator, protein S and C, antithrombin, fibrinogen, von Willebrand factor, thrombomodulin and prothrombin time (PT) were measured in patient plasma.
  
  
  RESULTS
  soluble thrombomodulin was significantly lower and von Willebrand factor (vWF) and tissue plasminogen activator (tPA) significantly higher in Behçet's patients. Patients with vascular involvement showed the highest levels of vWF and tPA. There was no activation of coagulation, not even in patients with an active disease at the time of sampling.
  
  
  CONCLUSIONS
  there were indirect signs of endothelial activity or damage, particularly in patients with vascular involvement. Coagulation was not activated.
authors.affiliation: Department of Surgery, Ankara University Hospital, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Demirer
authors.forename: N
authors.initials: N
authors.lastname: Sengül
authors.forename: M A
authors.initials: MA
authors.lastname: Yerdel
authors.forename: A
authors.initials: A
authors.lastname: Tüzüner
authors.forename: A T
authors.initials: AT
authors.lastname: Ulus
authors.forename: A
authors.initials: A
authors.lastname: Gürler
authors.forename: D
authors.initials: D
authors.lastname: Bergqvist
authors.forename: A
authors.initials: A
authors.lastname: Siegbahn
authors.forename: S
authors.initials: S
authors.lastname: Karacagil
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000378:metabolism; D001528:Behcet Syndrome / Q000097:blood*; D015415:Biomarkers; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000378:metabolism; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D012720:Severity of Illness Index; D018180:Thrombomodulin / Q000097:blood; D010959:Tissue Plasminogen Activator / Q000097:blood; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000991:Antithrombins; D015415:Biomarkers; D010446:Peptide Fragments; D011486:Protein C; D017293:Protein S; D018180:Thrombomodulin; C045879:prothrombin fragment 1.2; D014841:von Willebrand Factor; D011516:Prothrombin; D005340:Fibrinogen; D010959:Tissue Plasminogen Activator