title: Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism.
abstract: Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH.
authors.affiliation: Health and Medical Center, Okayama University, Japan. oguogu@cc.okayama-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ogura
authors.forename: K
authors.initials: K
authors.lastname: Tobe
authors.forename: Y
authors.initials: Y
authors.lastname: Mimura
authors.forename: F
authors.initials: F
authors.lastname: Otsuka
authors.forename: T
authors.initials: T
authors.lastname: Yamauchi
authors.forename: A
authors.initials: A
authors.lastname: Imai
authors.forename: C
authors.initials: C
authors.lastname: Tsukamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Iwasaki
authors.forename: K
authors.initials: K
authors.lastname: Matsuura
mesh_terms: D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D006063:Chorionic Gonadotropin / Q000008:administration & dosage / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007006:Hypogonadism / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D007027:Hypothalamic Diseases / Q000150:complications* / Q000188:drug therapy; D020738:Leptin / Q000378:metabolism*; D008297:Male; D008596:Menotropins / Q000008:administration & dosage / Q000627:therapeutic use; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
chemical_list: D006063:Chorionic Gonadotropin; D020738:Leptin; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D008596:Menotropins