Mechanical initiation of intervertebral disc degeneration.
METHODS
Mechanical testing of cadaveric lumbar motion segments.


OBJECTIVE
To test the hypothesis that minor damage to a vertebral body can lead to progressive disruption of the adjacent intervertebral disc.


BACKGROUND
Disc degeneration involves gross structural disruption as well as cell-mediated changes in matrix composition, but there is little evidence concerning which comes first. Comparatively minor damage to a vertebral body is known to decompress the adjacent discs, and this may adversely affect both structure and cell function in the disc.


METHODS
In this study, 38 cadaveric lumbar motion segments (mean age, 51 years) were subjected to complex mechanical loading to simulate typical activities in vivo while the distribution of compressive stress in the disc matrix was measured using a pressure transducer mounted in a needle 1.3 mm in diameter. "Stress profiles" were repeated after a controlled compressive overload injury had reduced motion segment height by approximately 1%. Moderate repetitive loading, appropriate for the simulation of light manual labor, then was applied to the damaged specimens for approximately 4 hours, and stress profilometry was repeated a third time. Discs then were sectioned and photographed.


RESULTS
Endplate damage reduced pressure in the adjacent nucleus pulposus by 25% +/- 27% and generated peaks of compressive stress in the anulus, usually posteriorly to the nucleus. Discs 50 to 70 years of age were affected the most. Repetitive loading further decompressed the nucleus and intensified stress concentrations in the anulus, especially in simulated lordotic postures. Sagittal plane sections of 15 of the discs showed an inwardly collapsing anulus in 9 discs, extreme outward bulging of the anulus in 11 discs, and complete radial fissures in 2 discs, 1 of which allowed posterior migration of nucleus pulposus. Comparisons with the results from tissue culture experiments indicated that the observed changes in matrix compressive stress would inhibit disc cell metabolism throughout the disc, and could lead to progressive deterioration of the matrix.


CONCLUSIONS
Minor damage to a vertebral body endplate leads to progressive structural changes in the adjacent intervertebral discs.
Adams
M A
MA
University of Bristol, United Kingdom.
Freeman
B J
BJ
Morrison
H P
HP
Nelson
I W
IW
Dolan
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena; D002102:Cadaver; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology; D007405:Intervertebral Disc Displacement / Q000473:pathology* / Q000503:physiopathology*; D008159:Lumbar Vertebrae / Q000293:injuries*; D008875:Middle Aged; D011312:Pressure; D016103:Spinal Fractures / Q000473:pathology* / Q000503:physiopathology*