Topographic mapping: organising by repulsion and competition?
The establishment of topographic maps of neuronal connections is believed to involve graded repulsion mediated by EphA receptors and ephrin-A ligands. Gene knockouts show that ephrin-A ligands do indeed have a crucial role in mapping, and that mechanisms in addition to graded repulsion must also be at work.
Wilkinson
D G
DG
Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, UK. dwilkin@nimr.mrc.ac.uk
D000818:Animals; D036384:Ephrin-A3; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009435:Synaptic Transmission
D036384:Ephrin-A3; D008565:Membrane Proteins