(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.
Gasparini
F
F
Nervous System Research, Novartis Pharma AG, Basel, Switzerland. fabrizio.gasparini@pharma.novartis.com
Inderbitzin
W
W
Francotte
E
E
Lecis
G
G
Richert
P
P
Dragic
Z
Z
Kuhn
R
R
Flor
P J
PJ
D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*
C119327:4-phosphonophenylglycine; D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; D005998:Glycine