Mercury intolerance in relation to superoxide dismutase, glutathione peroxidase, catalase, and the nitroblue tetrazolium responses.
Through percutaneous provocation with metallic mercury and phenyl mercuric acetate in patients stating the presence of subjective psychosomatic symptoms following dental amalgam treatment, it has been possible to categorize and score two extreme groups of patients, mercury-intolerant and mercury-tolerant patients reacting and not reacting, respectively, to low doses of mercury. The intolerant patients had a high psychosomatic score and the tolerant patients had a low or null score when exposed to low doses of the two mercury compounds. Determination of the scavenger enzymes superoxide dismutase, glutathione peroxidase, and catalase showed no significant differences between the mercury-intolerant and the mercury-tolerant patients and the controls. The activity of superoxide dismutase and the quantitative psychosomatic score elicited by either metallic mercury or phenyl mercuric acetate showed a positive correlation. On the other hand, analyses of the psychosomatic score and the areas under the curves of the nitroblue tetrazolium test response showed negative correlations. The results indicate that the oxidative metabolism and, in particular, superoxide dismutase may be perturbed in mercury-intolerant patients.
Marcusson
J A
JA
Department of Dermatology, Huddinge University Hospital, Huddinge, S-141 86, Sweden.
Carlmark
B
B
Jarstrand
C
C
D000368:Aged; D002374:Catalase / Q000378:metabolism*; D003723:Dental Amalgam / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D006968:Hypersensitivity, Delayed; D007202:Indicators and Reagents / Q000008:administration & dosage; D008297:Male; D008628:Mercury / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D009580:Nitroblue Tetrazolium / Q000008:administration & dosage; D011602:Psychophysiologic Disorders / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000378:metabolism*
D007202:Indicators and Reagents; D009580:Nitroblue Tetrazolium; D003723:Dental Amalgam; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D008628:Mercury