title: Pericyte migration from the vascular wall in response to traumatic brain injury.
abstract: Any perturbation of the blood brain barrier, whether from changes in cell physiology or from direct injury, may result in microvascular dysfunction and disease. We examined, at the ultrastructural level, microvascular pericyte responses in a well-defined model of traumatic brain injury in the rat. In areas close to the site of impact cortical pericytes underwent a number of changes within the first hour. Approximately 40% of pericytes migrated from their microvascular location. Migration occurred concomitant with a thinning of the abluminal surface of the basal lamina and an accumulation of the receptor for the urokinase plasminogen activator on the leading surface of the migrating cell. Migrated pericytes appeared viable and remained in a perivascular location in the adjacent neuropil. Nonmigrating pericytes in the same section displayed cytoplasmic alterations and nuclear chromatin changes consistent with a rapid degenerative process.
authors.affiliation: Department of Neurology, Detroit Medical Center, MI 48201, USA. pdduffy@med.wayne.edu
authors.forename: P
authors.initials: P
authors.lastname: Dore-Duffy
authors.forename: C
authors.initials: C
authors.lastname: Owen
authors.forename: R
authors.initials: R
authors.lastname: Balabanov
authors.forename: S
authors.initials: S
authors.lastname: Murphy
authors.forename: T
authors.initials: T
authors.lastname: Beaumont
authors.forename: J A
authors.initials: JA
authors.lastname: Rafols
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D001930:Brain Injuries / Q000473:pathology*; D002196:Capillaries / Q000473:pathology; D002465:Cell Movement; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D020286:Pericytes / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000502:physiology; D055293:Receptors, Urokinase Plasminogen Activator; D015854:Up-Regulation; D014949:Wounds, Nonpenetrating
chemical_list: C524900:Plaur protein, rat; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator