EAE susceptibility in FVB mice.
The in vivo study of immunologic mechanisms in experimental allergic encephalomyelitis (EAE) requires, in some instances, the use of transgenic mice. As FVB mice represent a strain whose fertilized ova possess a relatively large pronucleus, this is a preferred strain in which to generate mice that are transgenic for a variety of genes. An important issue, then, is whether the FVB background supports the development of EAE. We report here that relapsing EAE is easily and reproducibly induced in FVB mice with whole myelin basic protein in complete Freund's adjuvant.
Baker
A M
AM
Departments of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA.
Grekova
M C
MC
Richert
J R
JR
D000818:Animals; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000276:immunology; D008822:Mice, Transgenic / Q000235:genetics* / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D013116:Spinal Cord / Q000276:immunology / Q000473:pathology / Q000503:physiopathology