[Cytotoxic and cytogenetic effects of radiation are modulated by introduction of RNA preparations obtained from various body tissues].
We studied the influence of various gamma-ray doses on the death pattern of Wistar rats and the changes in lethality after introduction of RNA isolated from various tissues in the organism. All studied RNA introduced into the irradiated animals proved to clearly stimulate repair of the cells damaged by radiation and to decrease both cytotoxic and cytogenetic effects of gamma-rays. The most pronounced effect on the cells was specific for RNA isolated from the matching tissue.
Vitvitskiĭ
V N
VN
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Soboleva
L S
LS
Shevchenko
V A
VA
D000818:Animals; D001854:Bone Marrow Cells / Q000737:chemistry / Q000187:drug effects / Q000528:radiation effects; D002417:Cattle; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D007413:Intestinal Mucosa / Q000737:chemistry; D007421:Intestine, Small / Q000737:chemistry / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009928:Organ Specificity; D012313:RNA / Q000737:chemistry / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors
D012313:RNA
Izemenenie tsitoksicheskogo i tsitogeneticheskogo éffektov radiatsii pri vvedenii v organizm preparatov RNA, vydelennykh iz raznykh tkaneĭ.