[Contact dermatitis due to ethyl alcohol: how to perform patch tests?].
BACKGROUND
Ethyl alcohol sensitization is rare and can induce immediate contact urticaria or delayed eczema. Patch tests performed with ethanol can provoke an irritative reaction and are not well codified.


METHODS
We report on 4 cases of contact dermatitis due to alcohol in 4 women. Eczema was due to alcohol contained in the reservoir of a transdermal transfer system with estrogens in 2 cases and related to the application of alcoholized antiseptic lotions in the other 2 cases. In 2/4 cases we observed a co-sensitization with corticosteroids.


METHODS
Patch tests were performed with alcohol at 95 degrees diluted at 70 p. 100 and at 10 p. 100 in water and read after 20 minutes then on day 2 and day 4.


RESULTS
Positive results were obtained in 4/4 cases when alcohol was tested diluted at 70 p. 100 in water and in 3/4 cases when diluted at 10 p. 100 in water. No irritant reaction was observed in 140 negative controls.


CONCLUSIONS
Immediate after 20 minutes and delayed readings of patch tests performed with ethyl alcohol diluted at 70 p. 100 seem to be convenient in diagnosing cutaneous delayed hypersensitivity to alcohol. Co-sensitization between corticosteroids and alcohol could be due to an aldehyde deshydrogenase deficiency.
Barbaud
A
A
Service de Dermatologie, Hôpital Fournier, 36, quai de la Bataille, 54000 Nancy. a.barbaud@chu-nancy.fr
Trechot
P
P
Reichert-Penetrat
S
S
Schmutz
J
J
D000287:Administration, Topical; D000328:Adult; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000891:Anti-Infective Agents, Local / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D002648:Child; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004485:Eczema / Q000139:chemically induced; D000431:Ethanol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods*; D012997:Solvents / Q000009:adverse effects*; D014581:Urticaria / Q000139:chemically induced
D000891:Anti-Infective Agents, Local; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D012997:Solvents; D000431:Ethanol; D000444:Aldehyde Dehydrogenase
Eczéma de contact à l'alcool éthylique: comment réaliser les tests?