The impact of chirality of the fluorinated volatile inhalation anaesthetics on their clinical applications.
This review discusses the various chromatographic enantioseparation methods on an analytical and preparative scale for fluorinated inhalation anaesthetics used clinically, namely halothane, enflurane, desflurane and isoflurane. The differences in the pharmacodynamics and pharmacokinetics between the enantiomers of those anaesthetics are presented. It can be concluded that using a single enantiomer for these fluorinated anaesthetics is advantageous over using the racemic mixture. The racemic switch to a single enantiomer for these fluorinated volatile anaesthetics offers a more effective and safe general anaesthetic.
Aboul-Enein
H Y
HY
Bioanalytical and Drug Development Laboratory, Biological and Medical Research Department, MBC-03, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Saudi Arabia. enein@kfshrc.edu.sa
Bojarski
J
J
Szymura-Oleksiak
J
J
D018685:Anesthetics, Inhalation / Q000737:chemistry* / Q000494:pharmacology*; D017611:Fluorine Compounds / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism
D018685:Anesthetics, Inhalation; D017611:Fluorine Compounds