Corrected QT interval prolongation associated with intravenous haloperidol in acute coronary syndromes.
We report on three patients with acute coronary syndromes who developed QT interval prolongation associated with intravenous haloperidol use. One developed ventricular fibrillation. We also review 21 such patients from the literature. Haloperidol should be used with caution and QT intervals monitored closely in patients with coronary ischemia who may be prone to ventricular ectopy.
Douglas
P H
PH
Emory University School of Medicine, Atlanta, GA, USA.
Block
P C
PC
D000368:Aged; D000789:Angina, Unstable / Q000150:complications*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004562:Electrocardiography; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications*; D011595:Psychomotor Agitation / Q000150:complications / Q000188:drug therapy; D013577:Syndrome
D014150:Antipsychotic Agents; D006220:Haloperidol