title: Intravenous tPA in acute ischemic stroke related to internal carotid artery dissection.
abstract: The authors describe the outcomes in 11 patients who had acute ischemic stroke related to internal carotid artery (ICA) dissection and were treated with IV tissue plasminogen activator (tPA). One symptomatic intracerebral hemorrhage occurred 36 hours after tPA was given. The mean day 90 modified Rankin Scale (m-RS) score was 2.4 (+/-1.6). No death was observed at 3 months. Four patients of 11 (36.4%) made an excellent recovery (day 90 m-RS score: 0 to 1). This study demonstrates the feasibility of IV thrombolysis with tPA (0.8 mg/kg) in ischemic stroke related to ICA dissection within the first 7 hours.
authors.affiliation: Service d'Urgences Neurovasculaires, Hôpital Neurologique, Lyon, France. lderex@yahoo.com
authors.forename: L
authors.initials: L
authors.lastname: Derex
authors.forename: N
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: F
authors.initials: F
authors.lastname: Turjman
authors.forename: M
authors.initials: M
authors.lastname: Hermier
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: P
authors.initials: P
authors.lastname: Neuschwander
authors.forename: J C
authors.initials: JC
authors.lastname: Froment
authors.forename: P
authors.initials: P
authors.lastname: Trouillas
mesh_terms: D000328:Adult; D000368:Aged; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D020215:Carotid Artery, Internal, Dissection / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000627:therapeutic use*; D011859:Radiography; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator