Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor.
Four of 10 patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony-stimulating factor. There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.
Openshaw
H
H
Department of Neurology, City of Hope National Medical Center, Duarte, CA 91010, USA. hopenshaw@coh.org
Stuve
O
O
Antel
J P
JP
Nash
R
R
Lund
B T
BT
Weiner
L P
LP
Kashyap
A
A
McSweeney
P
P
Forman
S
S
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D010243:Paralysis / Q000139:chemically induced / Q000188:drug therapy; D011994:Recombinant Proteins
D000893:Anti-Inflammatory Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D008775:Methylprednisolone