Effects of intrapartum administration of invert sugar and D5LR on neonatal blood glucose levels.
OBJECTIVE
To compare the effects of D5LR and invert sugar administered intrapartum on neonatal blood glucose concentrations.


METHODS
This is a prospective, randomized, double-blind study. A total of 32 insulin-requiring diabetic patients were randomized to receive either intravenous 10% invert sugar or lactated Ringer's solution with 5% dextrose (D5LR). Regular insulin was given intravenously with an infusion pump to maintain the plasma glucose concentration between 60 and 90 mg/dl. Neonatal blood glucoses were measured at 30 minutes after birth, four times every hour, and thereafter as indicated. Student's t-test was used for continuous variables and Fisher's exact test was used for categorical data.


RESULTS
There were no differences in neonatal blood glucose levels, incidence of neonatal hypoglycemia, or length of neonatal hospital stay between the two groups.


CONCLUSIONS
Intrapartum administration of invert sugar is not associated with better neonatal homeostasis of glucose compared with using D5LR. Thus, given the expense of invert sugar, D5LR appears to be preferable for intrapartum control of maternal blood glucose.
Wright
T E
TE
Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, Albuquerque 67131, USA.
Martin
D
D
Qualls
C
C
Curet
L B
LB
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D005632:Fructose / Q000008:administration & dosage* / Q000378:metabolism; D005865:Gestational Age; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control; D007262:Infusions, Intravenous; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D010952:Plasma Substitutes / Q000008:administration & dosage; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy*; D011295:Prenatal Care; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D001786:Blood Glucose; D007328:Insulin; D010952:Plasma Substitutes; D005632:Fructose; C008133:invert sugar; D005947:Glucose