title: PDZ domains in synapse assembly and signalling.
abstract: Synaptic junctions are highly specialized structures designed to promote the rapid and efficient transmission of signals from the presynaptic terminal to the postsynaptic membrane within the central nervous system. Proteins containing PDZ domains play a fundamental organizational role at both the pre- and postsynaptic plasma membranes. This review focuses on recent advances in our understanding of the mechanisms underlying the assembly of synapses in the central nervous system.
authors.affiliation: Dept of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. garner@nrc.uab.edu
authors.forename: C C
authors.initials: CC
authors.lastname: Garner
authors.forename: J
authors.initials: J
authors.lastname: Nash
authors.forename: R L
authors.initials: RL
authors.lastname: Huganir
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000737:chemistry / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins