Improvement of ischaemia-reperfusion injury by lazaroid U74389G in rat lung transplantation model.
The effect of lazaroid 74389G on ischaemia-perfusion injury in a rat lung transplantation model was investigated using three administration methods. In all groups, the University of Wisconsin (UW) solution was used as a flush and preservation solution at 4 degrees C, and lungs were stored for 12 h. Group I rats (controls) were not given any lazaroid treatment. In group II, lazaroid U74389G was added to the UW solution (100 micromol/l). In group III, lazaroid (10 mg/kg) was intravenously injected in the donors 30 min before lung ischaemia. Group IV received lazaroid treatment by the combined methods of groups II and III. In all the experimental groups (II-IV), recipient rats were given lazaroid (6 mg/kg) intravenously 30 min before reperfusion. Lazaroid improved the gas exchange function (groups II, III and IV), reduced the tissue lipid peroxides (group II) and ameliorated histologic lung damage (group II). The results thus seemed to be better in group II than in groups III and IV.
Kuwaki
K
K
Department of Thoracic and Cardiovascular Surgery, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Komatsu
K
K
Sohma
H
H
Abe
T
T
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004195:Disease Models, Animal; D016040:Lung Transplantation; D008297:Male; D011281:Pregnatrienes / Q000627:therapeutic use*; D051381:Rats; D011917:Rats, Inbred Lew; D015427:Reperfusion Injury / Q000517:prevention & control*
D000975:Antioxidants; D011281:Pregnatrienes; C074965:U 74389F