title: Early perioperative results and surgical recurrence after strictureplasty and miniresection for complicated Crohn's disease.
abstract: OBJECTIVE
  Strictureplasty (SP) or miniresective 'bowel-sparing' techniques (MR) can prevent the risk of intestinal stomia and short bowel syndrome in patients affected by Crohn's disease (CD). The aim of this study was to analyze the perioperative morbidity and mortality in 104 of 138 consecutive patients treated for CD complications using bowel-sparing techniques. We also considered the factors that may be related to the risk of perioperative complications and the long-term outcome.
  
  
  METHODS
  One hundred and four patients were treated with SP and/or MR and then included in a prospectively maintained database. The factors claimed to influence perioperative complications were analyzed using Fisher's exact test for categorical observations and the Mann-Whitney U test for continuous variables. A multivariate analysis, using logistic regression, and a long-term time-to-event analysis using the Kaplan-Meier function, were also performed.
  
  
  RESULTS
  Perioperative mortality was nil. In relation to the 6 postoperative complications (5.8%), 4 patients underwent minimal bowel resection (MR), 1 a MR with SP, and 1 SP alone. Three of these patients (2.9%) needed reoperation for septic complications, and 3 (2.9%) were treated as outpatients for enterocutaneous fistulas. A correlation (p < 0.05) was found between low serum hemoglobin levels and postoperative complications at univariate and multivariate analyses. The 5-year surgical recurrence-free rate was 75% overall, 73% for patients treated with SP, 78% with MR, and 77% with MR + SP.
  
  
  CONCLUSIONS
  Postoperative complications are not related to conservative or miniresective surgery even when active disease is present at the resection margins or the site of SP. The higher risk reported for patients with low serum hemoglobin and hematocrit levels suggests that surgeons should consider using preoperative iron and vitamin support, parenteral nutrition and erythropoietin therapy, when necessary, in those cases. Our postoperative morbidity, mortality and long-term surgical recurrence rate results support the efficacy and safety of SP and MR surgery in the treatment of complicated CD.
authors.affiliation: Division of General Surgery, Ospedale 'Luigi Sacco', Università degli Studi di Milano, Italia.
authors.forename: G M
authors.initials: GM
authors.lastname: Sampietro
authors.forename: M
authors.initials: M
authors.lastname: Cristaldi
authors.forename: T
authors.initials: T
authors.lastname: Porretta
authors.forename: G
authors.initials: G
authors.lastname: Montecamozzo
authors.forename: P
authors.initials: P
authors.lastname: Danelli
authors.forename: A M
authors.initials: AM
authors.lastname: Taschieri
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications* / Q000601:surgery*; D013505:Digestive System Surgical Procedures; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins