[The bone regeneration process under chymotrypsin exposure (an experimental study)].
Disturbance of femur diaphysis compact substance was induced experimentally in rabbits. In the course of the operation single administration of crystalline chimotripsin into the wound was performed and its influence on bony structures regeneration was studied. Methods of light and scanning electron microscopy revealed that reparative processes started earlier and were more active than that in control. This promotes regenerate formation and complete healing of bone defect. Intramuscular administration of proteolytic enzyme does not exert essential influence on bone regeneration.
Iarygin
N V
NV
Scientific Research Centre of Biomedical Technologies, Moscow.
Zoria
V I
VI
Doktorov
A A
AA
D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002918:Chymotrypsin / Q000494:pharmacology*; D003460:Crystallization; D018483:Diaphyses / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D005269:Femur / Q000187:drug effects / Q000293:injuries / Q000502:physiology; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013499:Surface Properties; D013997:Time Factors
D002918:Chymotrypsin
Protsess regeneratsii kosti pod vozdeĭstviem khimotripsina (éksperimental'noe issledovanie).