8-Difluoromethoxy-4-quinolone derivatives as anti-feline immunodeficiency virus (FIV) agents: important structural features for inhibitory activity of FIV replication.
The inhibitory activities of various 8-difluoromethoxy-4-quinolone derivatives against feline immunodeficiency virus (FIV) replication in the chronically infected cell line P-CrFK were investigated. Certain derivatives were found to inhibit FIV production from P-CrFK cells in a dose-dependent manner without exhibiting cytotoxic effects at inhibitory concentrations. Based on this study, the structures important for anti-FIV activity are suggested to be (i) a carboxyl group at position C-3, and (ii) an aromatic modification at position 4 of the C-7 piperazinyl moiety.
Kashiwase
H
H
Biological Research Laboratories, Sankyo Co., Ltd. Hiromachi, Tokyo ,Japan.
Katsube
T
T
Kimura
T
T
Nishigaki
T
T
Yamashita
M
M
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002415:Cats; D002478:Cells, Cultured; D003124:Colorimetry; D003588:Cytopathogenic Effect, Viral; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D016181:Feline Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects* / Q000502:physiology; D007202:Indicators and Reagents / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015363:Quinolones / Q000737:chemistry* / Q000627:therapeutic use; D013778:Tetrazolium Salts / Q000737:chemistry; D014779:Virus Replication / Q000187:drug effects
D000956:Antigens, Viral; D007202:Indicators and Reagents; D015363:Quinolones; D013778:Tetrazolium Salts