Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
Colostrum is the specific first diet of mammalian neonates and is rich in immunoglobulins, antimicrobial peptides, and growth factors. In this article we review some of these constituents of human and bovine colostrum in comparison with those of mature milk. Recent studies suggest that colostral fractions, or individual peptides present in colostrum, might be useful for the treatment of a wide variety of gastrointestinal conditions, including inflammatory bowel disease, nonsteroidal antiinflammatory drug-induced gut injury, and chemotherapy-induced mucositis. We therefore discuss the therapeutic possibilities of using whole colostrum, or individual peptides present in colostrum, for the treatment of various gastrointestinal diseases and the relative merits of the 2 approaches.
Playford
R J
RJ
Department of Gastroenterology, Imperial College School of Medicine, Hammersmith Hospital, London, UK. r.playford@ic.ac.uk
Macdonald
C E
CE
Johnson
W S
WS
D000818:Animals; D002417:Cattle; D003126:Colostrum / Q000737:chemistry*; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006133:Growth Substances / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D008892:Milk / Q000737:chemistry; D008895:Milk, Human / Q000737:chemistry*; D010455:Peptides / Q000302:isolation & purification / Q000627:therapeutic use; D011247:Pregnancy
D006133:Growth Substances; D010455:Peptides