title: Electrophysiological recordings in pallidotomy localized to 3D stereoscopic imaging.
abstract: A quantitative on-line analysis of electrical activity in the pallidum of Parkinsonian patients has been developed to determine the focal point of lesioning. A 3D volume image system has been developed to display basal ganglia anatomy and coregister the electrophysiological data within the globus pallidus. Thirty patients undergoing 41 pallidotomies are presented. Neuronal activity from the pallidum is recorded using a semi-microelectrode. Based on this activity, lesioning is performed. Postlesion recordings are made to determine the necessity of additional lesioning. A stereoscopic 3D volume MR image system has been developed that along with on-line signal processing allows visualization of high neural activity in the pallidum and postlesion residual activity.
authors.affiliation: Division of Neurosurgery, UMDNJ-Robert Wood Johnson Medical, New Brunswick, NJ 08901-1977, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Lehman
authors.forename: E
authors.initials: E
authors.lastname: Micheli-Tzanakou
authors.forename: J
authors.initials: J
authors.lastname: Zheng
authors.forename: J L
authors.initials: JL
authors.lastname: Hamilton
mesh_terms: D000200:Action Potentials; D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000627:therapeutic use; D001479:Basal Ganglia / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods*; D003131:Combined Modality Therapy; D004576:Electromyography; D004598:Electrosurgery; D005071:Evoked Potentials; D005917:Globus Pallidus / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008839:Microelectrodes; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods*; D009474:Neurons / Q000502:physiology; D009862:Online Systems; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa