title: Endogenous mediators and thrombophilia.
abstract: Platelets are one of the most important components of primary haemostasis. Since they lack a nucleus, their functional characteristics are determined at the time of production. The role of platelets in thrombosis is further modified by the interaction with vascular mediators that are endogenously produced in response to a variety of stimuli. This chapter discusses the factors that influence platelet production, the interaction with endogenous mediators, and the potential therapeutic benefits achieved by modifying this interaction in the clinical setting.
authors.affiliation: Centre for Vascular Biology and Medicine, Department of Medicine, University College London, UK.
authors.forename: J F
authors.initials: JF
authors.lastname: Martin
authors.forename: R E
authors.initials: RE
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Mathur
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000166:cytology / Q000502:physiology; D004730:Endothelium, Vascular / Q000737:chemistry / Q000473:pathology / Q000502:physiology; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009569:Nitric Oxide / Q000097:blood / Q000494:pharmacology / Q000502:physiology; D015539:Platelet Activation; D019851:Thrombophilia / Q000097:blood* / Q000378:metabolism*; D013927:Thrombosis / Q000097:blood / Q000209:etiology; D014665:Vasodilator Agents / Q000097:blood / Q000494:pharmacology
chemical_list: D014665:Vasodilator Agents; D009569:Nitric Oxide