The basal SAR of a novel insulin receptor activator.
The synthesis and SAR of analogues prepared from novel insulin receptor activator 1 are described. Changes to the dihydroxyquinone core were not tolerated while functionalization of the two indoles contained in 1 resulted in little effect upon activation of the insulin receptor.
Wood
H B
HB
Basic Chemistry, Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065, USA. blair_wood@merck.com
Black
R
R
Salituro
G
G
Szalkowski
D
D
Li
Z
Z
Zhang
Y
Y
Moller
D E
DE
Zhang
B
B
Jones
A B
AB
D011972:Receptor, Insulin / Q000819:agonists*; D013329:Structure-Activity Relationship
D011972:Receptor, Insulin