Potentiation of warfarin anticoagulation associated with topical methyl salicylate.
OBJECTIVE
To report a case of international normalized ratio (INR) elevation resulting from the administration of topical methyl salicylate in a patient whose INR was previously stable while she received warfarin anticoagulation.


METHODS
A 22-year-old white woman presented with an INR of 12.2 after applying a topical pain-relieving gel to her knees daily for eight days. The potentiation of the warfarin anticoagulation was attributed to the low-dose methyl salicylate contained in the product.


CONCLUSIONS
Methyl salicylate is systemically absorbed through the skin in measurable amounts, and may increase warfarin action by affecting vitamin K metabolism or by displacing warfarin from protein-binding sites. While several investigators have reported this interaction with use of high-dose methyl salicylate, this case indicates that a significant interaction can occur with the use of lower topical doses of methyl salicylate as well.


CONCLUSIONS
Healthcare providers and patients taking warfarin must be aware of the potential hazard of using topical methyl salicylate in combination with warfarin.
Joss
J D
JD
Department of Pharmaceutical Care, University of Iowa Health Care, Iowa City 52246, USA. jacqueline-joss@uiowa.edu
LeBlond
R F
RF
D000287:Administration, Topical; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects / Q000493:pharmacokinetics*; D004357:Drug Synergism; D005260:Female; D005404:Fixatives / Q000009:adverse effects / Q000493:pharmacokinetics*; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D019934:International Normalized Ratio; D009824:Ointments / Q000009:adverse effects / Q000493:pharmacokinetics; D012459:Salicylates / Q000009:adverse effects / Q000493:pharmacokinetics*; D014859:Warfarin / Q000009:adverse effects / Q000493:pharmacokinetics*
D000925:Anticoagulants; D005404:Fixatives; D009824:Ointments; D012459:Salicylates; D014859:Warfarin; C033069:methyl salicylate