title: A histopathological investigation on the effects of the bisphosphonate alendronate on resorptive phase following mucoperiosteal flap surgery in the mandible of rats.
abstract: BACKGROUND
  The present study was designed to examine histopathologically whether local delivery of aminobisphosphonate (alendronate) could be effective in preventing the alveolar bone resorption associated with mucoperiosteal flaps.
  
  
  METHODS
  Following mucoperiosteal flap elevation in the molar region of the rat mandible, a surgical pellet soaked with aminobisphosphonate was locally applied on the exposed bone surface and covered by flap. The determined parameters with a semi-quantitative subjective method for the histopathological evaluation were as follows: existing inflammatory cell infiltration of the related periodontal tissue; fibrotic component content and bundles of collagen fibers; the number and morphology of osteoclasts of the alveolar bone and interdental septum; existing resorption lacunae (osteoclast surfaces); and existing osteoblastic activity (forming surfaces).
  
  
  RESULTS
  The results showed that while there were no detectable statistically significant differences between the saline and alendronate-treated groups on the existing inflammatory cell infiltration (ICI), number of osteoclasts, and osteoblastic activity, the results for the fibrotic and collagen component, osteoclast morphologies, and existing resorption lacunae were statistically significant.
  
  
  CONCLUSIONS
  These results suggest that local application of the aminobisphosphonate alendronate can be used as an adjunct in therapy for reducing bone resorption following surgery. It can also be suggested for consideration that, even for the surgical approaches in dentistry where bone graft materials and/or dental implants are needed, using bisphosphonate may achieve a new dimension in periodontal therapy in the near future.
authors.affiliation: Ankara University Faculty of Dentistry, Department of Periodontology, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Kaynak
authors.forename: R
authors.initials: R
authors.lastname: Meffert
authors.forename: M
authors.initials: M
authors.lastname: Günhan
authors.forename: O
authors.initials: O
authors.lastname: Günhan
authors.forename: O
authors.initials: O
authors.lastname: Ozkaya
mesh_terms: D019386:Alendronate / Q000494:pharmacology* / Q000627:therapeutic use; D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000818:Animals; D016723:Bone Remodeling / Q000187:drug effects*; D008297:Male; D016555:Matched-Pair Analysis; D010006:Osteoblasts / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D051381:Rats
chemical_list: D019386:Alendronate