title: Fat distribution and health in obesity.
abstract: Although independent associations of visceral fat with the insulin resistance syndrome were previously reported in obese women, the importance of truncal subcutaneous fat in this syndrome is controversial. The method by which the various fat depots are measured may be the reason for the underlying controversy. In the past five years, we have used various methods to measure visceral versus subcutaneous fat distribution in Caucasian (C) and African-American (AA) women and have related it to insulin sensitivity (SI) and to blood lipids, particularly fasting serum triglyceride levels (TG). Elevated TG levels in obese women were best predicted by an increased amount of visceral fat, whereas the amounts of truncal and peripheral subcutaneous fat did not have an impact on them. These results were confirmed, regardless of the method used to measure the fat depots. Insulin resistance (low SI) in obese women was predicted by both an increase of visceral and of upper-body (truncal) subcutaneous fat. However, measurements of the entire visceral and truncal subcutaneous fat volumes may be needed to confirm this latter association.
authors.affiliation: Obesity Research Center, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA. jbal@columbia.edu
authors.forename: J B
authors.initials: JB
authors.lastname: Albu
authors.forename: A J
authors.initials: AJ
authors.lastname: Kovera
authors.forename: J A
authors.initials: JA
authors.lastname: Johnson
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D044383:Black People; D001823:Body Composition; D001824:Body Constitution; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology*; D012016:Reference Values; D012867:Skin; D012885:Skinfold Thickness; D014481:United States; D014781:Viscera; D044465:White People; D001741:Black or African American