Expressions of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor on angiogenesis in intestinal-type gastric carcinoma.
We examined the clinical and pathological significance of thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) in human gastric carcinomas, in terms of intratumoral microvessel density (IMVD), P53 expression, and patient prognosis in a total of 128 patients. Mean IMVD was significantly higher in the carcinomas with dThdPase or VEGF expression than in carcinomas without the expression. The simultaneous expression of dThdPase and VEGF was correlated with increased IMVD of human gastric carcinomas. VEGF expression was associated with P53 expression and poor patient prognosis, but dThdPase expression was not.
Sakatani
T
T
First Department of Pathology, Faculty of Medicine, Tottori University, Yonago/Tottori 683-8503, Japan.
Okamoto
E
E
Tsujitani
S
S
Ikeguchi
M
M
Kaibara
N
N
Ito
H
H
D000236:Adenoma / Q000098:blood supply / Q000401:mortality / Q000473:pathology / Q000601:surgery; D016228:Endothelial Growth Factors / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008222:Lymphokines / Q000032:analysis*; D008297:Male; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D011379:Prognosis; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D013939:Thymidine Phosphorylase / Q000032:analysis*; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013939:Thymidine Phosphorylase