Immunomodulatory activity of hexapeptides related to proline rich peptide from colostrum.
Twelve analogues of an immunomodulatory hexapeptide YVPGFP (I) derived from Proline rich peptide (from colostrum) have been synthesized with modifications at positions 2, 4 and 6. In MLR assay one of the analogues exhibited approx 50% inhibition at 0.1 microg/mL concentration in contrast to prednisolone and I which caused around 70 and 20% suppression respectively, at the same concentration.
Kundu
B
B
Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
Puri
A
A
Singh
G
G
Sahai
R
R
Tripathi
L M
LM
Srivastava
V M
VM
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D003126:Colostrum / Q000737:chemistry*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry*; D055232:Proline-Rich Protein Domains
D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010455:Peptides