title: Intrathoracic fluid volumes and pulmonary function during orthotopic liver transplantation.
abstract: BACKGROUND
  Impaired pulmonary function is a frequent finding in patients undergoing orthotopic liver transplantation (OLT). Experimental data suggest an essential contribution of splanchnic ischemia and reperfusion as a result of intraoperative volume shifts, i.e., the accumulation of extravascular lung water (EVLW). Increases of intrathoracic blood volume (ITBV) and pulmonary blood volume (PBV) might additionally influence pulmonary capillary fluid filtration. The main objective of this study was to determine the intrathoracic volume changes during OLT and to test whether there were any relationships between intra- and extravascular volume shifts and pulmonary function, as determined by the calculation of venous admixture (QS/QT) and alveolar-arterial oxygen gradient (AaDO2).
  
  
  METHODS
  Twenty-five patients undergoing OLT were studied. Using the transpulmonary double indicator dilution method, ITBV, PBV, and EVLW were determined from the mean transit times and exponential decay times of the indocyanine green and the thermal indicator curves recorded simultaneously with a fiberoptic catheter in the descending aorta. Recordings were made after induction of anesthesia, at the end of the anhepatic stage, immediately after reperfusion, and 1 and 4 h postoperatively.
  
  
  RESULTS
  Significant increases in QS/QT related to changes of ITBV were observed after reperfusion. Only a minor impact on AaDO2 was perceived. EVLW remained constant during the study period.
  
  
  CONCLUSIONS
  Postreperfusion increases of ITBV influence pulmonary function, as demonstrated by the increase in QS/QT. However, they need not be associated with greater EVLW levels, and impact on oxygenation is less severe than assumed. Hence, sufficient mechanisms protecting oxygenation and stalling increased EVLW seem to be present during uncomplicated human OLT.
authors.affiliation: Department of Anesthesiology and General Intensive Care, University of Vienna, Austria.
authors.forename: C G
authors.initials: CG
authors.lastname: Krenn
authors.forename: W
authors.initials: W
authors.lastname: Plöchl
authors.forename: A
authors.initials: A
authors.lastname: Nikolic
authors.forename: P G
authors.initials: PG
authors.lastname: Metnitz
authors.forename: C
authors.initials: C
authors.lastname: Scheuba
authors.forename: C K
authors.initials: CK
authors.lastname: Spiss
authors.forename: H
authors.initials: H
authors.lastname: Steltzer
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D001826:Body Fluids / Q000378:metabolism*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007432:Intraoperative Period; D016031:Liver Transplantation; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011659:Pulmonary Gas Exchange; D013909:Thorax / Q000098:blood supply / Q000378:metabolism*