title: Prevalence of gestational diabetes mellitus in polycystic ovarian syndrome (PCOS) patients pregnant after ovulation induction with gonadotrophins.
abstract: Our aims were: 1. To investigate if women with PCOS who become pregnant using gonadotrophins have a higher incidence of gestational diabetes mellitus (GDM) compared to spontaneously pregnant matched control women, 2. To compare the prevalence of GDM in PCOS women with that in women with hypo/eugonadotrophic hypogonadism and in unexplained infertility and 3. To investigate differences in pregnancy outcomes between the groups. This was a retrospective case-control study. Women with PCOS were matched with a control by age, BMI, and ethnicity. There were 60 women with PCOS, 11 with hypogonadotrophic hypogonadism, 6 with eugonadotrophic hypogonadism, and 12 with unexplained infertility. Control women were those who attended a major public hospital for antenatal care and delivery We found no difference in the prevalence of GDM between the PCOS (22%) and the controls (17%) or between the PCOS and other groups. Women with GDM (diet or insulin controlled) had a significantly higher BMI than women without GDM (p = 0.019). There was no difference in pregnancy outcomes between the groups. There was a significant dependence of babies' birthweight on mother's BMI (p<0.001).
authors.affiliation: Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Vollenhoven
authors.forename: S
authors.initials: S
authors.lastname: Clark
authors.forename: G
authors.initials: G
authors.lastname: Kovacs
authors.forename: H
authors.initials: H
authors.lastname: Burger
authors.forename: D
authors.initials: D
authors.lastname: Healy
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000453:epidemiology*; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D014739:Victoria / Q000453:epidemiology
chemical_list: D006062:Gonadotropins