Brain tumors as second malignant neoplasms in patients with osteosarcoma treated with adjuvant and neoadjuvant chemotherapy: report of 2 cases.
A malignant, primary brain tumor developed as Second Malignant Neoplasm (SMN) in 2/490 long-term-survivor osteosarcoma patients treated at our Institute over a 20-yr period. They developed the brain tumor (one astrocytoma and one glioblastoma) 3 and 5 yr after treatment, (chemotherapy and surgery), for localized osteosarcoma of the extremity.
Longhi
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A
Department of Musculo-Skeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy. chemioterapia@ior.it
Gamberi
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Bacci
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G
D000328:Adult; D001254:Astrocytoma; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D001932:Brain Neoplasms; D017024:Chemotherapy, Adjuvant; D005909:Glioblastoma; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*