title: High incidence of laryngopharyngeal reflux in patients with head and neck cancer.
abstract: OBJECTIVE
  Laryngopharyngeal reflux may play a role in the etiology of squamous cell cancer of the head and neck and contribute to complications in head and neck cancer patients after surgery or during radiotherapy.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  To investigate the incidence of laryngopharyngeal and gastroesophageal reflux in patients with head and neck cancer, ambulatory 24-hour double-probe pH monitoring was performed in 24 untreated patients with laryngeal or pharyngeal squamous cell carcinoma. In addition, 10 patients who had been irradiated in the head and neck area were analyzed for reflux to study the effect of radiotherapy on reflux.
  
  
  RESULTS
  Only 4 of the 24 head and neck cancer patients (17%) had neither pathological laryngopharyngeal nor gastroesophageal reflux. Esophageal acid exposure was abnormal in five patients and acid exposure at the level of the upper esophageal sphincter was abnormal in four patients. Eleven patients had pathological reflux in both areas. Irradiated patients did not differ from the untreated patients considering the incidence of pathological laryngopharyngeal or gastroesophageal reflux.
  
  
  CONCLUSIONS
  The data obtained in this study indicate that reflux is a common event in head and neck cancer patients.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Academic Medical Center, University of Amsterdam, The Netherlands. copper@nki.nl
authors.forename: M P
authors.initials: MP
authors.lastname: Copper
authors.forename: C F
authors.initials: CF
authors.lastname: Smit
authors.forename: L D
authors.initials: LD
authors.lastname: Stanojcic
authors.forename: P P
authors.initials: PP
authors.lastname: Devriese
authors.forename: P F
authors.initials: PF
authors.lastname: Schouwenburg
authors.forename: L M
authors.initials: LM
authors.lastname: Mathus-Vliegen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D006258:Head and Neck Neoplasms / Q000150:complications*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007013:Hypopharynx / Q000503:physiopathology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies