title: The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues.
abstract: A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated. All these compounds showed an average GI50 value in the range of 3.9-28.9 microM. SAR studies showed that the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity.
authors.affiliation: Department of Ophthalmology, School of Medicine, University of Washington, Seattle 98195-6485, USA.
authors.forename: V A
authors.initials: VA
authors.lastname: Kuksa
authors.forename: V A
authors.initials: VA
authors.lastname: Pavlov
authors.forename: P K
authors.initials: PK
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013095:Spermidine / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D013095:Spermidine