title: Immunomodulatory activity of hexapeptides related to proline rich peptide from colostrum.
abstract: Twelve analogues of an immunomodulatory hexapeptide YVPGFP (I) derived from Proline rich peptide (from colostrum) have been synthesized with modifications at positions 2, 4 and 6. In MLR assay one of the analogues exhibited approx 50% inhibition at 0.1 microg/mL concentration in contrast to prednisolone and I which caused around 70 and 20% suppression respectively, at the same concentration.
authors.affiliation: Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: B
authors.initials: B
authors.lastname: Kundu
authors.forename: A
authors.initials: A
authors.lastname: Puri
authors.forename: G
authors.initials: G
authors.lastname: Singh
authors.forename: R
authors.initials: R
authors.lastname: Sahai
authors.forename: L M
authors.initials: LM
authors.lastname: Tripathi
authors.forename: V M
authors.initials: VM
authors.lastname: Srivastava
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D003126:Colostrum / Q000737:chemistry*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D010455:Peptides / Q000737:chemistry*; D055232:Proline-Rich Protein Domains
chemical_list: D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010455:Peptides