Non-specific viral infections as possible synchronising events of the manifestation of type 1 diabetes.
Four cases of simultaneous manifestation of Type 1 diabetes in two members of the same household are reported. In all cases, a flu-like infection preceded diabetes onset. Surprisingly, despite simultaneous development of insulin dependency, insulin requirements were strikingly different at 3 months in all cases. These observations suggest that increased insulin resistance during infection may cause insulin deficiency in individuals with widely varying residual beta cell activity.
Wasmuth
H E
HE
German Diabetes Research Institute at the University of Düsseldorf, Germany.
Hess
G
G
Viergutz
C
C
Henrichs
H R
HR
Martin
S
S
Kolb
H
H
D003922:Diabetes Mellitus, Type 1 / Q000209:etiology* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D007333:Insulin Resistance; D008297:Male; D014777:Virus Diseases / Q000150:complications*
D007328:Insulin