The effect of extracts of Cynomorium coccineum and Withania somnifera on gonadotrophins and ovarian follicles of immature Wistar rats.
The effects of water extracts of Cynomorium coccineum and Withania somnifera on ovarian follicular development and serum levels of FSH and LH were studied in immature 17-day-old and 25-day-old-Wistar rats. Water extracts of the plants were given to the animals per os in a dose of 47 mg/100 g body weight for 6 days. Serum levels of FSH and LH were measured by ELISA. Folliculogenesis was studied with a light microscope. In 25-day-old rats, extracts of both plants elicited significant changes in gonadotrophin levels coupled with a significant increase in ovarian weight and profound folliculogenesis. Numerous primary, secondary, tertiary and antral follicles were present. A distinct zona pellucida was not seen and the oocyte was often detached. In 17-day-old animals there was a significant increase-in body weight but without significant changes in the ovarian weight and folliculogenesis.
Al-Qarawi
A A
AA
Department of Veterinary Medicine, King Saud University, P.O. Box 1482, Buraidah, Kingdom of Saudi Arabia.
Abdel-Rahman
H A
HA
El-Badry
A A
AA
Harraz
F
F
Razig
N A
NA
Abdel-Magied
E M
EM
D000818:Animals; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D006080:Ovarian Follicle / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone