The genetics of Graves' disease.
Graves' disease is a complex autoimmune disorder in which several genetic susceptibility loci and environmental factors are likely to contribute to the development of disease. HLA and the CTLA-4 gene region have been established as susceptibility loci, although the magnitude of their contributions seems to vary between data sets and geographic populations. Genome-wide searches are beginning to identify new loci, including GD-1, GD-2, and GD-3, although these loci have only been found in one data set. Additional loci are likely to be identified via a combination of genome-wide linkage analysis and allelic association analysis of candidate genes.
Gough
S C
SC
Division of Medical Sciences, University of Birmingham, United Kingdom. s.c.gough@bham.ac.uk
D000069594:Abatacept; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000235:genetics; D060908:CTLA-4 Antigen; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D018796:Immunoconjugates; D008285:Major Histocompatibility Complex; D013602:T-Lymphocytes, Cytotoxic
D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D006680:HLA Antigens; D018796:Immunoconjugates; D000069594:Abatacept