Growth hormone and markers of immune function in children with renal transplants.
Lymphocyte subsets and T cell activation markers were measured in ten children with renal transplants for up to 1 year before and during their 1st year of recombinant human growth hormone (rhGH) treatment. The number of lymphocytes, helper or cytotoxic T cells or natural killer cells, and the T cell expression of CD25, CD26 and HLA-DR antigens were not altered by rhGH. B cell numbers declined both before and during treatment. There was no difference in lymphocyte subset numbers between children with and without rejection episodes.
Maxwell
H
H
Department of Paediatric Nephrology, Institute of Child Health, London, UK. heather.maxwell@yorkhill.scot.nhs.uk
Amlot
P
P
Rees
L
L
D000293:Adolescent; D015415:Biomarkers; D001772:Blood Cell Count / Q000187:drug effects; D002648:Child; D005260:Female; D006084:Graft Rejection / Q000139:chemically induced* / Q000453:epidemiology; D013006:Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D018655:Lymphocyte Count / Q000187:drug effects; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000032:analysis
D015415:Biomarkers; D007166:Immunosuppressive Agents; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D019382:Human Growth Hormone; D013006:Growth Hormone