title: Stability of extemporaneous norfloxacin suspension.
abstract: The stability of norfloxacin as extemporaneous suspensions compounded from two brands of film-coated tablets (formulas I and II) was studied. The vehicle consisted of tragacanth, saccharin sodium, sorbitol solution, glycerin, paraben concentrate, peppermint spirit BP, purified water, and syrup USP. The final concentration of norfloxacin in the suspensions was 20 mg/ml. Formulas I and II were chemically stable for 28 days when stored in amber glass bottles at ambient temperature; however, their physical characteristics were different.
authors.affiliation: Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Boonme
authors.forename: N
authors.initials: N
authors.lastname: Phadoongsombut
authors.forename: P
authors.initials: P
authors.lastname: Phoomborplub
authors.forename: S
authors.initials: S
authors.lastname: Viriyasom
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000032:analysis; D009643:Norfloxacin / Q000008:administration & dosage* / Q000032:analysis; D013535:Suspensions; D013607:Tablets
chemical_list: D004791:Enzyme Inhibitors; D013535:Suspensions; D013607:Tablets; D009643:Norfloxacin