title: Structure and antiprotozoal activity of triterpenoid saponins from Glinus oppositifolius.
abstract: Two new triterpenoid saponins, glinosides A and B, isolated from the aerial parts of Glinus oppositifolius, have been characterized by 1D, 2D, NMR and high-resolution mass spectral (HRMS) techniques. Their structures were established respectively as 16-O-(beta-arabinopyranosyl)-3-oxo-12,16 beta,21 beta,22-tetrahydroxyhopane for glinoside A and 16-O-(beta-arabinopyranosyl)-3-oxo-12,16 beta,22-trihydroxyhopane for glinoside B. Results presented evidence that fractions had a better antiplasmodial activity (IC50 = 31.80 micrograms/ml) than pure glinoside A (IC50 = 42.30 micrograms/ml).
authors.forename: F
authors.initials: F
authors.lastname: Traore
authors.forename: R
authors.initials: R
authors.lastname: Faure
authors.forename: E
authors.initials: E
authors.lastname: Ollivier
authors.forename: M
authors.initials: M
authors.lastname: Gasquet
authors.forename: N
authors.initials: N
authors.lastname: Azas
authors.forename: L
authors.initials: L
authors.lastname: Debrauwer
authors.forename: A
authors.initials: A
authors.lastname: Keita
authors.forename: P
authors.initials: P
authors.lastname: Timon-David
authors.forename: G
authors.initials: G
authors.lastname: Balansard
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D012503:Saponins; D014315:Triterpenes