Enthalpies of solution of ampicillin, amoxycillin and their binary mixtures at 310.15 K.
Enthalpies of solutions of ampicillin, amoxycillin and their binary mixtures have been determined at pH 2, 5, and 7 using C-80 calorimeter. The systems showed endothermic behaviour; molar enthalpies of solutions of ampicillin were determined to be 13.32, 15.89 and 23.21 kJ mol(-1) and amoxycillin were 16.32, 18.45 and 26. 25 kJ mol(-1) at pH 2, 5, and 7, respectively. The excess molar enthalpies of solution have also been calculated to find any interaction between these two drugs.
Jain
D V
DV
University Institute of Pharmaceutical Sciences, Punjab University, 160014, Chandigharh, India.
Kashid
N
N
Kapoor
S
S
Chadha
R
R
D000658:Amoxicillin / Q000737:chemistry*; D000667:Ampicillin / Q000737:chemistry*; D002151:Calorimetry; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D006863:Hydrogen-Ion Concentration; D019999:Pharmaceutical Solutions; D013816:Thermodynamics
D004338:Drug Combinations; D019999:Pharmaceutical Solutions; D000667:Ampicillin; D000658:Amoxicillin