[Blood physiological resources and their role in physiological adaptation of the body to blood loss (based on the experimental data and calculations)].
In white rats, loss of about 66 +/- 3% of the blood volume results in an abrupt drop of the BP and arrest of the lung respiration. Introduction of a plasma substitute in the volume equal to the lost blood resulted in an increase of the BP and restoration of rhythmical respiration in 9 out of 14 experimental rats. Haematocrit after the blood loss and subsequent administration of the substitute was about 15%. Previously obtained data show that the Ht of about 15% decreases the oxygen transport to tissues. However, an increase in the lung ventilation, a shift of the haemoglobin dissociation curve to the right, an increase of oxygen extraction from the blood, and an increase in the minute blood volume by 50-100%, allow a sufficient oxygen transport to the organism tissues to be ensured at the Ht of about 15%. Thus, the reserve of the blood respiration function of the blood remaining after a life-threatening blood loss plays an important physiological role in replenishing the volume of the lost blood with the plasma substitute and in survival of the organism.
Ivanov
K P
KP
Pavlov Institute of Physiology of the Russian Acad. Sci., St. Petersburg, Russia.
D000818:Animals; D001794:Blood Pressure; D001802:Blood Substitutes / Q000494:pharmacology; D001810:Blood Volume / Q000502:physiology*; D006400:Hematocrit; D020896:Hypovolemia / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration
D001802:Blood Substitutes; D010100:Oxygen
Fiziologicheskie rezervy krovi i ikh rol' v fiziologicheskoĭ adaptatsii organizma k krovopotere (po rezul'tatam éksperimentov i raschetov).