title: Lambert-Eaton myasthenic syndrome: electrodiagnostic findings and response to treatment.
abstract: The authors reviewed the incidence of cancer, repetitive nerve stimulation findings, and response to treatment in 73 patients with Lambert-Eaton myasthenic syndrome. Thirty-one patients (42%) had lung cancer, 29 small cell. Doubling of the compound motor action potential amplitude in three tested distal muscles was seen in only 41% of patients. Treatment with 3, 4-diaminopyridine produced moderate to marked self-reported functional improvement in 79% of the 53 treated patients.
authors.affiliation: Duke University Medical Center, Durham, NC 27710, USA. rtim@acpub.duke.edu
authors.forename: R W
authors.initials: RW
authors.lastname: Tim
authors.forename: J M
authors.initials: JM
authors.lastname: Massey
authors.forename: D B
authors.initials: DB
authors.lastname: Sanders
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077770:Amifampridine; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000188:drug therapy; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000175:diagnosis* / Q000188:drug therapy; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015221:Potassium Channels / Q000627:therapeutic use
chemical_list: D015221:Potassium Channels; D015761:4-Aminopyridine; D000077770:Amifampridine