title: Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists.
abstract: Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction and resulted in a series of 'carba' analogues. Potency in the VCAM-VLA-4 assay was sensitive to ring size and lower than that of the parent disulfide.
authors.affiliation: Roche Research Center, Hoffmann-La Roche Inc, Nutley, NJ 07110, USA. jefferson.tilley@roche.com
authors.forename: J
authors.initials: J
authors.lastname: Tilley
authors.forename: G
authors.initials: G
authors.lastname: Kaplan
authors.forename: N
authors.initials: N
authors.lastname: Fotouhi
authors.forename: B
authors.initials: B
authors.lastname: Wolitzky
authors.forename: K
authors.initials: K
authors.lastname: Rowan
mesh_terms: D039041:Integrin alpha4beta1; D016023:Integrins / Q000037:antagonists & inhibitors*; D018716:Molecular Mimicry; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D016201:Receptors, Lymphocyte Homing / Q000037:antagonists & inhibitors*; D019010:Vascular Cell Adhesion Molecule-1 / Q000187:drug effects*
chemical_list: D039041:Integrin alpha4beta1; D016023:Integrins; D010456:Peptides, Cyclic; D016201:Receptors, Lymphocyte Homing; D019010:Vascular Cell Adhesion Molecule-1