Etiology of autoimmunity.
Autoimmunity reflects the destruction of host tissue by the immune system. In my laboratory we are focused on understanding autoimmunity and the complex regulation of the autoimmune process. We believe that host defense mechanisms, which are normally activated to fight microorganisms, can malfunction and attack self. The role of cytokines and other host-elicited factors are a major focus of our group.
Sarvetnick
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Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA. noras@scripps.edu
D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology; D006801:Humans; D051379:Mice; D016688:Mice, Inbred NOD