Exploitation of gene context.
Recently, a number of techniques have been proposed that use completely sequenced genomes for the function prediction of individual proteins encoded therein. They use the fusion of genes, their conserved location in operons or merely their co-occurrence in genomes to predict the existence of functional interactions between the proteins they encode. This type of information complements functional features that are predicted by classical homology-based search techniques.
Huynen
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European Molecular Biology Laboratory, Max-Delbrück-Centrum for Molecular Medicine, Heidelberg, Berlin-Buch, 69117, 13122, Germany. huynen@embl-heidelberg.de
Snel
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Lathe
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Bork
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D000818:Animals; D016678:Genome; D015894:Genome, Human; D006801:Humans; D011237:Predictive Value of Tests; D011506:Proteins / Q000235:genetics*; D017421:Sequence Analysis; D017385:Sequence Homology
D011506:Proteins