title: Multifactorial thrombotic-type microangiopathy with skin ulcers and hepatitis C infection.
abstract: The case of a patient with hepatitis C virus infection who presented with symmetric ulcers of the legs is reported. She was found to have type III mixed cryoglobulinemia, high titers of anticardiolipin antibodies, lupus anticoagulant, and a free protein S deficiency. To our knowledge, this is the first reported case of such an association. The role of these factors in the pathogenesis of skin lesions in the setting of hepatitis C virus infection is discussed.
authors.affiliation: Department of Internal Medicine, Hospital Marqués de Valdecilla, University of Cantabria, 39008, Santander, Spain
authors.initials: JL
authors.lastname: Hernández
authors.initials: R
authors.lastname: Zarrabeitia
authors.initials: H
authors.lastname: Fernández-Llaca
authors.initials: L
authors.lastname: Hortal
authors.initials: J
authors.lastname: González-Macías