[The immunomodulating and antitoxic properties of preparations of lipopolysaccharides from representatives of the genus Francisella].
The study of the biological properties of lipopolysaccharides (LPS) of bacteria of the genus Francisella (F. tularensis, F. novicida, F. novicida-like, F. philomiragia) revealed that the preparation of Francisella LPS possessed immunomodulating and antitoxic properties in the absence of toxicity. At the same time the structure of LPS (S or R) was found to produce an essential effect of the immunobiological activity of this molecule. Thus, the S-forms of LPS proved to be more effective as immunomodulators and the R-forms of LPS, as antagonists of classical endotoxins.
Maslova
N N
NN
Research Institute for Plague Control, Rostov-on-Don, Russia.
Pavlovich
N V
NV
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000992:Antitoxins / Q000494:pharmacology*; D004731:Endotoxins / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005603:Francisella / Q000276:immunology* / Q000472:pathogenicity; D007114:Immunization / Q000379:methods; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D051381:Rats; D012486:Salmonella typhimurium; D013997:Time Factors; D014774:Virulence / Q000276:immunology
D000276:Adjuvants, Immunologic; D000992:Antitoxins; D004731:Endotoxins; D008070:Lipopolysaccharides
Immunomoduliruiushchie i antitoksicheskie svoĭstva preparatov lipopolisakharidov predstaviteleĭ roda Francisella.