Cervical papanicolaou smear abnormalities and Chlamydia trachomatis in sexually active adolescent females.
OBJECTIVE
To examine the effect of cervical Chlamydia trachomatis infection on the prevalence of Papanicolaou (Pap) smear abnormalities in adolescent females.


METHODS
Retrospective study performed by examination of previously obtained cervical C. trachomatis cultures and Pap smear results.


METHODS
Urban adolescent health care clinic in the Bronx, New York.


METHODS
Sexually active females, aged 13 to 23 (mean age: 17.9 years), attending the clinic for evaluation of sexually transmitted diseases.


METHODS
Patients who had undergone a gynecological examination with performance of cervical Pap smears and culture for C. trachomatis were enrolled in the study.


METHODS
Determine the prevalence of cervical C. trachomatis infection and compare cervical smear abnormalities in those with and without infection.


RESULTS
Of a study population of 257 females, 24 patients (9.3%) were culture positive for C. trachomatis and 58 patients (22.6%) had significant cervical smear abnormalities, i.e., atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LGSIL), or high grade squamous intraepithelial lesion (HGSIL). The 24 patients infected with C. trachomatis showed the following cervical smear abnormalities: within normal limits-37.5%, benign cellular changes-41.7%, ASCUS-12. 5%, and LGSIL-8.3%. A total of 233 patients (90.7%) were culture negative for C. trachomatis and showed the following cervical smear abnormalities: within normal limits-37.3%, benign cellular changes-39.9%, ASCUS-13.3%, LGSIL-8.6%, and HGSIL-.9%. Statistical analysis suggested no significant differences between the two groups (P >.9 by the Kruskal-Wallace test).


CONCLUSIONS
The isolation of C. trachomatis from the cervix of sexually active adolescent females at a single point in time does not impact on the prevalence of significant cervical smear abnormalities.
Edelman
M
M
Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10467, USA.
Fox
A
A
Alderman
E
E
Neal
W
W
Shapiro
A
A
Silver
E J
EJ
Spigland
I
I
Suhrland
M J
MJ
D000293:Adolescent; D000294:Adolescent Behavior; D000328:Adult; D002584:Cervix Uteri / Q000382:microbiology / Q000473:pathology*; D002690:Chlamydia Infections / Q000150:complications* / Q000453:epidemiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D015995:Prevalence; D012189:Retrospective Studies; D012725:Sexual Behavior; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology