title: [The action of pertussis vaccines and GMDP on the change in the enzymatic activity of macrophages from peritoneal exudate].
abstract: The influence of whole-cell and acellular pertussis vaccines, introduced both alone and in combination with N-acetylglucosaminylmuramyl-2-alanine-D-isoglutamine (GMDP) on the activity of two enzymes of peritoneal exudate macrophages (5'-nucleotidase and Na+K(+)-adenosine triphosphatase) was studied. The study revealed that both pertussis vaccines exhibited immunomodulating properties, these properties being most pronounced in whole-cell pertussis vaccine. The use of GMDP in combination with pertussis vaccines led to changes in the enzymatic activity of peritoneal exudate macrophages, which was indicative of a decrease in the immunomodulating action of pertussis preparations.
authors.affiliation: Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Ermolova
authors.forename: M V
authors.initials: MV
authors.lastname: Britsina
authors.forename: M N
authors.initials: MN
authors.lastname: Ozeretskovskaia
authors.forename: I B
authors.initials: IB
authors.lastname: Shepeleva
authors.forename: N S
authors.initials: NS
authors.lastname: Zakharova
mesh_terms: D015720:5'-Nucleotidase / Q000187:drug effects; D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000187:drug effects; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology*; D004305:Dose-Response Relationship, Drug; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000201:enzymology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000494:pharmacology*; D015164:Vaccines, Inactivated / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D010567:Pertussis Vaccine; D015164:Vaccines, Inactivated; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C063429:glucosaminylmuramyl-2-alanine-D-isoglutamine; D015720:5'-Nucleotidase; D000251:Adenosine Triphosphatases
vernacular_title: Izuchenie deĭstviia kokliushnykh vaktsin i GMDP na izmenenie fermentativnoĭ aktivnosti makrofagov peritoneal'nogo ékssudata.