title: The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection.
abstract: OBJECTIVE
  To determine amniotic fluid concentrations and correlations of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and leukocyte adhesion molecule-1 (LAM-1) in patients with and without intra-amniotic infection.
  
  
  METHODS
  Fourteen specimens with intra-amniotic infection and 45 without intra-amniotic infection were studied. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture. Amniotic fluid IL-6, ICAM-1, and LAM-1 levels were determined by an enzyme-linked immunoassay, and normalized by amniotic fluid creatinine levels.
  
  
  RESULTS
  Amniotic fluid concentrations of IL-6 and LAM-1 were significantly higher in patients with than without intra-amniotic infection. However, amniotic fluid ICAM-1 concentrations were not significantly different between two groups. Amniotic fluid IL-6, LAM-1, and ICAM-1 were positively correlated.
  
  
  CONCLUSIONS
  Our data indicate that amniotic fluid IL-6 is significantly associated with an increased adhesion molecule expression in intra-amniotic infection. However, LAM-1 plays a more important role than ICAM-1 in intra-amniotic infection.
authors.affiliation: Department of OB/GYN, Yale University School of Medicine, New Haven, CT 06525, USA. chaur-dong.hsu@yale.edu
authors.forename: C D
authors.initials: CD
authors.lastname: Hsu
authors.forename: K
authors.initials: K
authors.lastname: Aversa
authors.forename: E
authors.initials: E
authors.lastname: Meaddough
mesh_terms: D000653:Amniotic Fluid / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology
chemical_list: D015815:Cell Adhesion Molecules; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1