title: Applications of supercritical fluid extraction and chromatography in forensic science.
abstract: Supercritical fluid technology is a rapidly expanding analytical technique. Here we give a brief insight into the background of supercritical fluid technology and how supercritical fluid extraction and supercritical fluid chromatography work in analysis. The applications of these two techniques in forensic science are known to be important. The main area of forensic use of supercritical fluid technology is in the sample preparation and separation of drugs of abuse particularly opiates, cannabinoids, cocaine and sedatives. Supercritical fluid technology can be used for both time-of-death-related drug analysis and for obtaining information relating to long term drug abuse. We also give a review of the use of supercritical fluids in two other major forensic areas, fingerprinting and the extraction and separation of explosives from both bombing events and gunshot residues. Overall we show that supercritical fluid technology is fast becoming a major part of forensic investigations and that it is an invaluable analysis technique.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Greater, Manchester, UK.
authors.forename: C
authors.initials: C
authors.lastname: Radcliffe
authors.forename: K
authors.initials: K
authors.lastname: Maguire
authors.forename: B
authors.initials: B
authors.lastname: Lockwood
mesh_terms: D002186:Cannabinoids / Q000032:analysis; D002845:Chromatography / Q000295:instrumentation* / Q000379:methods*; D003042:Cocaine / Q000032:analysis; D005554:Forensic Medicine / Q000379:methods*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis; D013287:Illicit Drugs / Q000032:analysis; D009294:Narcotics / Q000032:analysis; D014948:Wounds, Gunshot
chemical_list: D002186:Cannabinoids; D006993:Hypnotics and Sedatives; D013287:Illicit Drugs; D009294:Narcotics; D003042:Cocaine