I2-Imidazoline receptors and monoamine oxidase B enzyme sites in human brain: covariation with age.
An association between monoamino oxidase B enzyme (MAO-B) sites and I(2)-imidazoline receptors (I(2)-IR) has been established in human brain on the basis of correlational studies of radiolabelled binding sites. Because both MAO-B and I(2)-IR densities increase with aging, the age at death could be partially involved in the observed correlations. The evaluation of two independent but similar datasets demonstrated that the linear correlation between MAO-B and I(2)-IR densities dropped from 0.70 (P=0.02) and 0.41 (P=0.14) in the crude analyses to the negligible values of 0.07 (P=0.84) and 0.09 (P=0.75) when the age at death was controlled for in the statistical analyses. The results lead to conclude, contrary to former interpretations, that there is not any statistical association linking both MAO-B catalytic unit sites and I(2)-IR densities in the human brain.
Ballesteros
J
J
Department of Neurosciences, University of the Basque Country, E-48940 Leioa, Bizkaia, Spain.
Maeztu
A I
AI
Callado
L F
LF
Gutiérrez
M
M
García-Sevilla
J A
JA
Meana
J J
JJ
D000293:Adolescent; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D001665:Binding Sites / Q000502:physiology; D001921:Brain / Q000201:enzymology* / Q000378:metabolism / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002384:Catalysis / Q000187:drug effects; D002648:Child; D005260:Female; D006801:Humans; D019329:Idazoxan / Q000494:pharmacology; D054755:Imidazoline Receptors; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010848:Picolinic Acids / Q000494:pharmacology; D011955:Receptors, Drug / Q000378:metabolism*
D000317:Adrenergic alpha-Antagonists; D054755:Imidazoline Receptors; D008996:Monoamine Oxidase Inhibitors; D010848:Picolinic Acids; D011955:Receptors, Drug; C059303:lazabemide; D008995:Monoamine Oxidase; D019329:Idazoxan