title: Central nervous system Hodgkin's lymphoma without systemic manifestation: case report and review of the literature.
abstract: A 66-year-old woman treated for ocular myasthenia gravis with azathioprine for 12 years presented with a left fronto-parietal mass. Histology revealed primary Hodgkin's lymphoma of the central nervous system with CD30, Epstein-Barr virus (EBV) latent membrane protein and CD20-positive, CD45 (LCA)-negative Reed-Sternberg cells surrounded by T cells. Moreover, EBV-encoded RNA-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy chain CDR2 locus were detected.
authors.affiliation: Department of Neurology, University of Tübingen, Germany. ulrich.herrlinger@uni-tuebingen.de
authors.forename: U
authors.initials: U
authors.lastname: Herrlinger
authors.forename: K
authors.initials: K
authors.lastname: Klingel
authors.forename: R
authors.initials: R
authors.lastname: Meyermann
authors.forename: R
authors.initials: R
authors.lastname: Kandolf
authors.forename: E
authors.initials: E
authors.lastname: Kaiserling
authors.forename: R D
authors.initials: RD
authors.lastname: Kortmann
authors.forename: A
authors.initials: A
authors.lastname: Melms
authors.forename: M
authors.initials: M
authors.lastname: Skalej
authors.forename: J
authors.initials: J
authors.lastname: Dichgans
authors.forename: M
authors.initials: M
authors.lastname: Weller
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D016543:Central Nervous System Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D011859:Radiography; D016896:Treatment Outcome