Enzymatic activity is not a precondition for the intracellular calcium increase mediated by mAbs specific for aminopeptidase N/CD13.
Navarrete Santos
A
A
Institute of Medical Immunology, Martin Luther University Halle, Germany. alexander.navarrete@medizin.uni-halle.de
Langner
J
J
Riemann
D
D
D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D018826:CD13 Antigens / Q000037:antagonists & inhibitors / Q000276:immunology / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000187:drug effects*; D006801:Humans; D006877:Hydroxamic Acids / Q000494:pharmacology; D017136:Ion Transport / Q000187:drug effects; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology; D020298:U937 Cells / Q000187:drug effects / Q000201:enzymology
D000911:Antibodies, Monoclonal; D006877:Hydroxamic Acids; D009363:Neoplasm Proteins; D009842:Oligopeptides; D011480:Protease Inhibitors; C063432:probestin; D018826:CD13 Antigens; D007930:Leucine; C012211:ubenimex; C010531:actinonin; D002118:Calcium