title: New biologically active rubiginones from Streptomyces sp.
abstract: Four new polyketides, named rubiginone D2 (2), 4-O-acetyl-rubiginone D2 (3), rubiginone H (6) and rubiginone I (7) were isolated from the cultures of Streptomyces sp. (strain Gö N1/5). Their structures were established by a detailed spectroscopic analysis. The absolute configuration of 3 was determined by derivatization with chiral acids (Helmchen's method). The rubiginones inhibit the growth of some Gram-positive bacteria and are cytostatically active against different tumor cell lines.
authors.affiliation: Institut für Organische Chemie, Universität Göttingen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Puder
authors.forename: A
authors.initials: A
authors.lastname: Zeeck
authors.forename: W
authors.initials: W
authors.lastname: Beil
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013237:Stereoisomerism; D013302:Streptomyces; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000095602:Angucyclines and Angucyclinones
chemical_list: D000880:Anthraquinones; D000900:Anti-Bacterial Agents; C066105:rubiginones; D000095602:Angucyclines and Angucyclinones