9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis.
9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.
Bakkestuen
A K
AK
Department of Chemistry, University of Oslo, Norway.
Gundersen
L L
LL
Langli
G
G
Liu
F
F
Nolsøe
J M
JM
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*
D000995:Antitubercular Agents; D011687:Purines