Lupene-type triterpenes from Periploca aphylla.
Two new lupane derivatives, 3beta,6alpha-dihydroxylup-20(29)-ene (1) and 6alpha-hydroxylup-20(29)-en-3beta-octadecanoate (2), have been isolated from the stems of Periploca aphylla, in addition to beta-sitosterol and lupeol. The structures of 1 and 2 were determined by spectral and chemical methods. Compound 1 showed strong inhibition of alpha-glucosidase type VI and a moderate antibacterial activity.
Mustafa
G
G
International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Anis
E
E
Ahmed
S
S
Anis
I
I
Ahmed
H
H
Malik
A
A
Shahzad-ul-Hassan
S
S
Choudhary
M I
MI
D001409:Bacillus cereus / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D011513:Proteus mirabilis / Q000187:drug effects; D012485:Salmonella typhi / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013297:Streptococcus pyogenes / Q000187:drug effects
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors