title: Pyrrolo[3,2,1-ij]quinoline derivatives, a 5-HT2c receptor agonist with selectivity over the 5-HT2a receptor: potential therapeutic applications for epilepsy and obesity.
abstract: A series of pyrrolo[3,2,1-ij]quinoline derivatives was synthesized, evaluated for their activity against the 5-HT2c and 5-HT2a, receptors and found to be agonists at 5-HT2c with selectivity over 5-HT2a.
authors.affiliation: NPS Allelix Corp., Mississauga, ON, Canada. misaac@allelix.com
authors.forename: M
authors.initials: M
authors.lastname: Isaac
authors.forename: A
authors.initials: A
authors.lastname: Slassi
authors.forename: A
authors.initials: A
authors.lastname: O'Brien
authors.forename: L
authors.initials: L
authors.lastname: Edwards
authors.forename: N
authors.initials: N
authors.lastname: MacLean
authors.forename: D
authors.initials: D
authors.lastname: Bueschkens
authors.forename: D K
authors.initials: DK
authors.lastname: Lee
authors.forename: K
authors.initials: K
authors.lastname: McCallum
authors.forename: I
authors.initials: I
authors.lastname: De Lannoy
authors.forename: L
authors.initials: L
authors.lastname: Demchyshyn
authors.forename: R
authors.initials: R
authors.lastname: Kamboj
mesh_terms: D019440:Anti-Obesity Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D019440:Anti-Obesity Agents; D000927:Anticonvulsants; D011758:Pyrroles; D011804:Quinolines; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists