title: Trends in antiretroviral therapy and mother-infant transmission of HIV. The Women and Infants Transmission Study Group.
abstract: Trends in the vertical transmission rate of HIV and evolving antiretroviral usage between 1990 and 1998 within the Women and Infants Transmission Study were evaluated. A decline in mother-infant transmission was temporally associated with advances in therapy, especially when regimens including a protease inhibitor were included in the analysis.
authors.affiliation: Boston Medical Center, Department of Pediatrics, Boston University School of Medicine, Massachusetts, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Cooper
authors.forename: M
authors.initials: M
authors.lastname: Charurat
authors.forename: D N
authors.initials: DN
authors.lastname: Burns
authors.forename: W
authors.initials: W
authors.lastname: Blattner
authors.forename: R
authors.initials: R
authors.lastname: Hoff
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000635:transmission*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D009035:Mothers; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D011446:Prospective Studies; D015215:Zidovudine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D015215:Zidovudine