title: Nutritional factors in high blood pressure.
abstract: Metabolism of Na+, Ca+ and Zn+ cations is clearly disturbed and involved in the development and maintenance of a hypertensive condition. These changes are closely related to each other; therefore, when their effects on primary hypertension (PH) are studied, they should always be globally (and not separately) considered. These changes of the aforementioned electrolytes in PH maintain a close, but unclear, relationship with various hormonal systems, mainly with the renin-angiotensin-aldosterone system. Daily control in the intake of these electrolytes (especially Na+ and Ca++) remains a cornerstone in the adjuvant treatment of PH. Na+ dietary restriction is indicated in hypertensives showing higher sensitivity to salt; in most cases they have low (70%) plasma renin activity (PRA) and belong to one of the following five groups: black, elderly, obese or diabetic (type 2) patients, and mixed blood young people from our community with low levels of PRA and serum ionic calcium. For best results, this moderate Na+ restriction (4-6 g of NaCl) should always be accompanied by an oral calcium supplement, or at least the assurance that the subject takes an appropriate amount of Ca++ (>800 mg/day) in his/her diet. Hypertensives with low PRA exhibit obvious changes of their calcium metabolism. We do not know the role of Zn++ in the development of PH; however, older hypertensives with very low PRA have high urinary excretion of Zn++ with low serum levels, a factor that could contribute to Zn++ depletion in these hypertensive patients. The oral administration of calcium corrects the Zn++ changes by a still unclear mechanism.
authors.affiliation: Service of Nephrology for Adults, Dr. Enrique Tejera Hospital, Carabobo University, Valencia, Venezuela.
authors.forename: J L
authors.initials: JL
authors.lastname: Zozaya
mesh_terms: D000375:Aging / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D002118:Calcium / Q000378:metabolism*; D019587:Dietary Supplements; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control; D009752:Nutritional Status / Q000502:physiology*; D012083:Renin / Q000097:blood; D012307:Risk Factors; D012964:Sodium / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D012964:Sodium; D012083:Renin; D015032:Zinc; D002118:Calcium