Radioimmunoscintigraphy of gastric adenocarcinomas with 99mTc-chimeric ccM4 antibody.
Fourteen patients with gastric lesions were studied for radioimmunoscintigraphy using the 99mTc-ccM4 chimeric antibody reactive with the human tumor-associated TAG72 antigen. These include 10 gastric adenocarcinomas, 3 gastric ulcers and 1 gastric lymphoma. Each patient received an infusion of 30-40 mCi 99mTc-ccM4 antibody. Gamma camera scans were performed at 12-h postadministration. All patients underwent operation after radioimmunoscintigraphy. All surgical specimens including gastric adenocarcinomas, lymphoma and ulcers were confirmed by histopathological studies. The 99mTc-ccM4 antibody was able to detect 6 out of 10 gastric adenocarcinomas (60%) by scans. Its accuracy was even 5 out of 6 (83%) in a group of patients with well/moderately-differentiated adenocarcinomas. In addition to the primary adenocarcinomatous lesions, the 99mTc-ccM4 antibody was also able to detect metastatic lesions in liver and lymph nodes. The smallest adenocarcinomatous lesion detected by scans was about 1 x 1 x 2 cm3. All four patients with gastric ulcers or lymphoma showed negative scan results. Therefore, the chimeric ccM4 antibody may be useful in radioimmunoscintigraphy of gastric adenocarcinomas, especially the well/moderately-differentiated adenocarcinomas.
Zhang
Y
Y
Department of Nuclear Medicine, Third Clinical College, Norman Bethune University of Medical Sciences, Jilin, Chian.
Ma
Q
Q
Zhao
J
J
Gao
F
F
Liu
S
S
Wang
Q
Q
Chen
Y
Y
Xiang
J
J
D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D051379:Mice; D016719:Radioimmunodetection; D011993:Recombinant Fusion Proteins; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging*; D013667:Technetium
D000951:Antigens, Neoplasm; D006023:Glycoproteins; D011993:Recombinant Fusion Proteins; C047052:tumor-associated antigen 72; D013667:Technetium