title: Cancer-related depression: Part II--Neurologic alterations and evolving approaches to psychopharmacology.
abstract: OBJECTIVE
  To describe evolving psychopharmacologic options for managing depression related to cancer.
  
  
  METHODS
  Literature review and case study.
  
  
  RESULTS
  Optimal recovery from depression requires early detection and selection of psychopharmacologic agents--singly or in combination--to address each depressive symptom.
  
  
  CONCLUSIONS
  Adequate psychopharmacologic management of depression requires consistent, informed involvement of healthcare professionals, patients, and caregivers. Patients and caregivers need to be prepared to assess responses to therapy, recognize adverse effects, manage minor side effects and threats to adherence, and seek appropriate assistance for adverse events, including drug-drug interactions.
  
  
  CONCLUSIONS
  Oncology nurses need to take an active role in assessing, documenting, and monitoring patients' responses to antidepressants, particularly during key phases (e.g., induction, substitutions, augmentation, withdrawal). Nurses also need to take an active role in screening patients for depression, preparing patients and caregivers for psychopharmacologic management of depression, and reinforcing these competencies regularly. Oncology nurses also can be instrumental in recognizing signs and symptoms of treatment resistance and addressing these issues appropriately. Because of the rapid pace of psychopharmacologic research, oncology nurses need to update knowledge continuously to provide safe care to depressed patients with cancer.
authors.affiliation: College of Nursing, University of Massachusetts, Boston, USA.
authors.forename: N C
authors.initials: NC
authors.lastname: Lovejoy
authors.forename: D
authors.initials: D
authors.lastname: Tabor
authors.forename: P
authors.initials: P
authors.lastname: Deloney
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000451:nursing / Q000503:physiopathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009369:Neoplasms / Q000451:nursing / Q000523:psychology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D009730:Nursing Assessment
chemical_list: D000928:Antidepressive Agents; D018377:Neurotransmitter Agents