title: Volume transmission as a mechanism of time-dependent sensitization to antidepressant therapy.
abstract: Administration of certain drugs such as antidepressants have been shown to produce a phenomenon known as time-dependent sensitization, a process in which the acute effects of the drugs sensitize and grow over time. While both preclinical and clinical studies have demonstrated time-dependent sensitization, it is still uncertain how it occurs. It is possible that the mechanism by which time-dependent sensitization occurs may be via a type of transmission in the brain known as volume transmission. Signals released via this transmission have properties that may explain the process of time-dependent sensitization.
authors.affiliation: Brain Sciences Institute, Swinburne University of Technology, Victoria, Australia. pnathan@bsi.swin.edu.au
authors.forename: P
authors.initials: P
authors.lastname: Nathan
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002490:Central Nervous System / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D000928:Antidepressive Agents