The role of amniotic fluid interleukin-6, and cell adhesion molecules, intercellular adhesion molecule-1 and leukocyte adhesion molecule-1, in intra-amniotic infection.
OBJECTIVE
To determine amniotic fluid concentrations and correlations of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), and leukocyte adhesion molecule-1 (LAM-1) in patients with and without intra-amniotic infection.


METHODS
Fourteen specimens with intra-amniotic infection and 45 without intra-amniotic infection were studied. Intra-amniotic infection was defined as the presence of a positive amniotic fluid culture. Amniotic fluid IL-6, ICAM-1, and LAM-1 levels were determined by an enzyme-linked immunoassay, and normalized by amniotic fluid creatinine levels.


RESULTS
Amniotic fluid concentrations of IL-6 and LAM-1 were significantly higher in patients with than without intra-amniotic infection. However, amniotic fluid ICAM-1 concentrations were not significantly different between two groups. Amniotic fluid IL-6, LAM-1, and ICAM-1 were positively correlated.


CONCLUSIONS
Our data indicate that amniotic fluid IL-6 is significantly associated with an increased adhesion molecule expression in intra-amniotic infection. However, LAM-1 plays a more important role than ICAM-1 in intra-amniotic infection.
Hsu
C D
CD
Department of OB/GYN, Yale University School of Medicine, New Haven, CT 06525, USA. chaur-dong.hsu@yale.edu
Aversa
K
K
Meaddough
E
E
D000653:Amniotic Fluid / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000382:microbiology
D015815:Cell Adhesion Molecules; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1