[DNA repeats and homologous recombination: a probable role for DNA methylation in genome stability of eukaryotic cells].
Homologous recombination between DNA repeats directly threatens the intact transmission of repeat-rich eukaryotic genomes through mitotic and meiotic cell divisions. Besides several other factors already known, DNA methylation might contribute, in some eukaryotes, to the limitation of crossover events between repeats. A strong inhibitory effect of DNA methylation has now been directly demonstrated, in the filamentous fungus Ascobolus. This therefore reinforces the question of the biological impact of this DNA modification on the recombinational stability of repeat-rich genomes, such as those of mammals.
Colot
V
V
Institut Jacques Monod, UMR 7592, Centre National de la Recherche Scientifique, Université Paris 7, France. colot@ijm.jussieu.fr
Maloisel
L
L
Rossignol
J L
JL
D000818:Animals; D001203:Ascomycota / Q000235:genetics; D004247:DNA / Q000235:genetics*; D019175:DNA Methylation; D004271:DNA, Fungal / Q000235:genetics; D016678:Genome; D006801:Humans; D011995:Recombination, Genetic; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*
D004271:DNA, Fungal; D004247:DNA
ADN répété et recombinaison homologue: un rôle probable de la méthylation de l'ADN dans la stabilité des génomes des cellules eucaryotes.