The causative H+/K+ ATPase antigen in the pathogenesis of autoimmune gastritis.
The gastric H+/K+ ATPase is the causative autoantigen recognized by CD4+ T cells that mediate autoimmune gastritis. Pathogenic CD4+ T cells are regulated by CD25+CD4+ T cells. Here, it is proposed that waves of activation and migration of antigen presenting cells and CD4+ T cells to and from the target organ and draining lymph node result in tissue damage.
Toh
B H
BH
Department of Pathology and Immunology, Monash University Medical School, Victoria, Australia. Ban-Hock.Toh@med.monash.edu.au
Sentry
J W
JW
Alderuccio
F
F
D017951:Antigen Presentation; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005756:Gastritis / Q000209:etiology* / Q000276:immunology*; D017506:H(+)-K(+)-Exchanging ATPase / Q000276:immunology*; D006801:Humans
D017506:H(+)-K(+)-Exchanging ATPase