Role of prostaglandins in hypertension.
The role of prostaglandins (PGs) in hypertension (HT) is reviewed, emphasising their biochemical characteristics, physiological effects and functions, especially in the cardiovascular area, and the current evidence of their participation in the antihypertensive activity of a balanced mechanism to maintain normal blood pressure. Also, the clinical use of PGs and the future of such autacoids in the treatment of HT and other diseases or conditions is mentioned.
Colina-Chourio
J A
JA
Department of Physiology, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela.
Godoy-Godoy
N
N
Avila-Hernández
R M
RM
D000818:Animals; D012898:Autacoids / Q000627:therapeutic use; D015415:Biomarkers; D001794:Blood Pressure / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000378:metabolism / Q000503:physiopathology; D011453:Prostaglandins / Q000502:physiology*; D011982:Receptors, Prostaglandin / Q000378:metabolism; D014661:Vasoconstriction / Q000502:physiology
D012898:Autacoids; D015415:Biomarkers; D011453:Prostaglandins; D011982:Receptors, Prostaglandin