title: Yeast tissue phase of Emmonsia pasteuriana inoculated in golden hamster by intratesticular way.
abstract: The scope of our study was to present an experimental model reproducing the dimorphic yeast-like population (as for Histoplasma capsulatum, Blastomyces dermatitidis) similar to that observed in the cutaneous biopsy of an Italian woman who had never traveled abroad, being intravenous drug user and HIV positive for 10 years, finally infected with the new dimorphic fungus Emmonsia pasteuriana. Experimental inoculation was unsuccessful by intraperitoneal (i.p.) and intravenous (i.v.) ways in a mouse and in a guinea-pig model inoculated by cutaneous or subcutaneous routes, reason for that we chose the golden hamster, highly sensitive to dimorphic fungi as agents of systemic mycoses as histoplasmosis, blastomycosis, sporotrichosis, penicilliosis marneffei, paracoccidioidomycosis when the inoculation was done by intraperitoneal route. We inoculated young golden hamsters by i.p. and intratesticular ways. Only by this last route we reproduced an orchiepididymitis with necrosis, haemorrhages and a polymorphic yeast-like population similar to the polymorphism observed in the cutaneous biopsy of the patient. The intratesticular affinity of E. pasteuriana provided an interesting model for this infection.
authors.affiliation: Institut Pasteur, Unité de Mycologie, Paris, France.
authors.forename: E
authors.initials: E
authors.lastname: Drouhet
authors.forename: M
authors.initials: M
authors.lastname: Huerre
mesh_terms: D000328:Adult; D000818:Animals; D001706:Biopsy; D002912:Chrysosporium / Q000472:pathogenicity*; D006224:Cricetinae; D003881:Dermatomycoses / Q000150:complications / Q000382:microbiology; D004195:Disease Models, Animal; D005260:Female; D006679:HIV Seropositivity / Q000150:complications; D006801:Humans; D008297:Male; D008647:Mesocricetus; D051379:Mice; D009181:Mycoses / Q000150:complications / Q000503:physiopathology*; D013737:Testis