N-acetyl-beta-D-glucosaminidase is not a predictor, but an indicator of kidney injury in patients with cardiac surgery.
The urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) was evaluated in terms of its ability to predict renal failure following open-heart surgery. Twenty-two patients were divided into three groups; 6 patients with post-operative renal failure (RF group), 9 without renal failure (non-RF group) and 7 who underwent non-cardiac surgery (non-ECC group). NAG levels during operation were significantly higher in the non-RF group than in the non-ECC group (2.28 +/- 0.50 U vs. 0.39 +/- 0.06 U, p < 0.01). NAG levels in the RF group were not significantly different from those in the non-ECC group (1.12 +/- 0.28 U/hr vs. 0.39 +/- 0.06 U/hr, p > 0.1), and in the non-RF group (1.12 +/- 0.28 U/hr vs. 2.28 +/- 0.50 U/hr, p > 0.1). Post-operative NAG levels were not significantly different between the RF and non-RF groups, whereas post-operative creatinine clearance values were significantly different (on 2, 6 and 7 post-operative day, p < 0.05). Our data suggest that the kidney is predisposed to renal failure by cardiopulmonary bypass and the chance of renal failure depends in some part on post-operative patient management.
Hamada
Y
Y
Second Department of Surgery, Gunma University School of Medicine, Japan.
Kanda
T
T
Anzai
T
T
Kobayashi
I
I
Morishita
Y
Y
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D015415:Biomarkers / Q000652:urine; D006348:Cardiac Surgical Procedures; D003404:Creatinine / Q000652:urine; D006801:Humans; D008875:Middle Aged; D011184:Postoperative Period; D011237:Predictive Value of Tests; D051437:Renal Insufficiency / Q000201:enzymology* / Q000652:urine
D015415:Biomarkers; D003404:Creatinine; D000118:Acetylglucosaminidase