Myosin regulatory light chain as a critical substrate of cell death: a hypothesis.
As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present work, we hypothesize that the most probable substrate for DAP kinase is regulatory light chain of myosin II, by phosphorylating which the kinase can transduct death signals.
Gerashchenko
B I
BI
Department of Biological Science, Faculty of Science, Hiroshima University, Higashi-Hiroshima, Japan. bogdan@ue.ipc.hiroshima-u.ac.jp
Murata-Hori
M
M
Hosoya
H
H
D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D002118:Calcium / Q000378:metabolism; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D002147:Calmodulin / Q000378:metabolism; D064550:Death-Associated Protein Kinases; D006367:HeLa Cells; D006801:Humans; D018994:Myosin Light Chains / Q000378:metabolism*; D013379:Substrate Specificity
D051017:Apoptosis Regulatory Proteins; D002147:Calmodulin; D018994:Myosin Light Chains; D064550:Death-Associated Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D002118:Calcium