Bile duct size does not predict success of portoenterostomy for biliary atresia.
OBJECTIVE
Presence of large bile ducts (>200 microm) at the portal end-plate has been suggested to predict success after portoenterostomy. The authors reviewed their patients with biliary atresia to test the hypothesis that bile duct size in patients with successful portoenterostomy was no different than in the patients with unsuccessful portoenterostomy.


METHODS
The authors reviewed the patients at their institution from 1989 to 1998 who had the diagnosis of biliary atresia (n = 38). A pathologist blinded to the results of the operation confirmed the measurements of the bile duct remnants.


RESULTS
Five of the 38 patients did not have a portoenterostomy. They underwent cholangiogram and liver biopsy and were evaluated for liver transplantation. All patients who underwent surgery (n = 33) had a Roux-en-y hepaticojejunostomy. Twenty-one patients had successful surgery (64%) and 12 patients (36%) had unsuccessful surgery. The average age at operation in the successful group was 50.9 +/- 3 days and in failures, 57.9 +/- 4 days (P = .16). Duct size at the portal end-plate was not different between the successes and failures. Two of the patients in the success group had no evidence of bile ducts grossly or histologically.


CONCLUSIONS
Children presenting early in infancy (<3 months) with biliary atresia should undergo a portoenterostomy regardless of the size of the bile ducts at the time of exploration.
Langenburg
S E
SE
Children's Hospital of Michigan, Department of Pediatric General and Thoracic Surgery, Detroit 48202, USA.
Poulik
J
J
Goretsky
M
M
Klein
A A
AA
Klein
M D
MD
D001652:Bile Ducts / Q000473:pathology*; D001656:Biliary Atresia / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011171:Portoenterostomy, Hepatic; D012189:Retrospective Studies; D017211:Treatment Failure