Naproxen-induced leukocytoclastic vasculitis.
Cutaneous reactions to non-steroidal anti-inflammatory drugs (NSAIDs) are rare in spite of their wide use. Only a few cases of hypersensitivity angiitis related to naproxen have been described. We report the case of a 62-year-old woman in whom leukocytoclastic skin vasculitis, peripheral neuropathy and nephritis developed after a short naproxen treatment, and gradually regressed after discontinuation of the drug and under glucocorticoid therapy. In the light of the relevant literature, the clinical and laboratory features of this reversible condition are described.
Schapira
D
D
Department of Rheumatology, Rambam Medical Center and School of Medicine, Technion, Israel Institute of Technology, Haifa.
Balbir-Gurman
A
A
Nahir
A M
AM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects*; D009393:Nephritis / Q000139:chemically induced / Q000188:drug therapy; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000188:drug therapy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D009288:Naproxen; D011241:Prednisone