title: Classification of neurotoxic responses based on vulnerability of cellular sites.
abstract: An ideal classification of neurotoxic substances should link the vulnerable target of chemical attack to alterations in neural function. There is little basis for classifying agents based on their common use or physico-chemical properties. Outlined in this article are the principal cellular targets of substances that perturb the nervous system structure and function.
authors.affiliation: Department of Neurology, Albert Einstein College of Medicine, NY, USA.
authors.forename: H H
authors.initials: HH
authors.lastname: Schaumburg
authors.forename: P S
authors.initials: PS
authors.lastname: Spencer
mesh_terms: D000818:Animals; D006801:Humans; D009186:Myelin Sheath / Q000187:drug effects*; D009457:Neuroglia / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D020258:Neurotoxicity Syndromes / Q000145:classification* / Q000175:diagnosis; D009498:Neurotoxins / Q000145:classification* / Q000633:toxicity; D051381:Rats
chemical_list: D009498:Neurotoxins