title: [Myasthenic syndrome induced by lithium].
abstract: BACKGROUND
  Lithium salts can induce a dysfunction of the neuromuscular junction.
  
  
  METHODS
  A patient given lithium for bipolar psychosis developed a state of major fatigue revealing a myasthenia syndrome which resolved progressively after lithium withdrawal.
  
  
  CONCLUSIONS
  In the literature, we found 4 cases of neuromuscular junction disorders in patients treated with lithium. A myasthenia syndrome was induced by lithium in 3 cases and underlying myasthenia was disclosed by lithium in the last one. The long-term course in our patient was in favor of an induced syndrome rather than underlying myasthenia. We discuss the pathophysiological mechanisms. Lithium is a commonly prescribed drug. Clinicians should be aware of the possibility of neuromuscular junction disorder in patients taking lithium who develop muscle fatigue.
authors.affiliation: Service de Neurologie, CHU Pontchaillou, Rennes.
authors.forename: T
authors.initials: T
authors.lastname: Ronzière
authors.forename: P
authors.initials: P
authors.lastname: Auzou
authors.forename: C
authors.initials: C
authors.lastname: Ozsancak
authors.forename: P
authors.initials: P
authors.lastname: Magnier
authors.forename: J
authors.initials: J
authors.lastname: Sénant
authors.forename: D
authors.initials: D
authors.lastname: Hannequin
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D018692:Antimanic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D001714:Bipolar Disorder / Q000188:drug therapy; D002220:Carbamazepine / Q000627:therapeutic use; D005221:Fatigue / Q000139:chemically induced; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000139:chemically induced; D009157:Myasthenia Gravis / Q000139:chemically induced*; D009469:Neuromuscular Junction / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D018692:Antimanic Agents; D001569:Benzodiazepines; D002220:Carbamazepine; D008094:Lithium
vernacular_title: Syndrome myasthénique induit par le lithium.