Pharmacological prophylaxis of post-traumatic epilepsy.
Early and late epileptic seizures are a frequent complication of severe head traumas. The administration of anticonvulsant drugs immediately after head injury is commonly implemented as a prophylactic measure; however, there is a lack of consensus on the usefulness of prophylaxis with anticonvulsants for the prevention of late post-traumatic epilepsy (PTE). The inconsistent evidence accumulated so far from clinical studies, most nonrandomised and uncontrolled in design, and the limited knowledge of the processes underlying post-traumatic epileptogenesis, do not warrant empirical pharmacological prophylaxis with long term administration of conventional anticonvulsants. Phenytoin and phenobarbital (phenobarbitone) are used to a large extent in this indication. As a general rule, a benefit/risk analysis in individual patients should drive prophylactic drug prescription in PTE as it can have potential detrimental effects on a patient's recovery. New compounds, such as free-radical scavengers and antiperoxidants, show encouraging experimental results, but their clinical use is still very limited.
Iudice
A
A
Department of Neurosciences, Section of Neurology, University of Pisa, Italy. a.iudice@neuro.med.unipi.it
Murri
L
L
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D012640:Seizures / Q000188:drug therapy
D000927:Anticonvulsants