Iron as a vulnerability factor in nigrostriatal degeneration in aging and Parkinson's disease.
Recent findings strengthen the connection between iron accumulation in the basal ganglia, oxidative stress and nigrostriatal degeneration. Oxidative stress appears to be elevated in the normal human substantia nigra in comparison with other brain regions, and further increases occur in Parkinson's disease. Accumulation of iron may contribute to degeneration of nigral dopamine neurons by catalyzing oxidative damage to cell components and also by perturbing the network of interactions that modulate cellular redox status.
Floor
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Department of Molecular Biosciences, University of Kansas, Lawrence 66045, USA. floor@ukans.edu
D000375:Aging; D003342:Corpus Striatum / Q000473:pathology*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007501:Iron / Q000378:metabolism* / Q000502:physiology*; D008954:Models, Biological; D009434:Neural Pathways / Q000473:pathology*; D009474:Neurons / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013378:Substantia Nigra
D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D007501:Iron