title: [A cultured concentrated inactivated vaccine against tick-borne encephalitis studied during the immunization of children and adolescents].
abstract: The word deals with the results obtained in the study of the reactogenicity and immunological activity of concentrated and inactivated tissue-culture tick-borne encephalitis vaccine, manufactured by the Chumakov Institute of Poliomyelitis and Viral Encephalitides, in the immunization of children and adolescents. The vaccine proved to be moderately reactogenic and exhibited pronounced immunological activity. In 91.5% of the immunized children the fourfold increase of the antibody level was observed. On the basis of the data obtained in this study the tick-borne encephalitis vaccine was recommended for use in medical practice for the prophylaxis of tick-borne encephalitis among children and adolescents.
authors.affiliation: Tarasevich State Research Institute for Standardization and Control of Medical Biological Preparations, Moscow, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Pavlova
authors.forename: M A
authors.initials: MA
authors.lastname: Gorbunov
authors.forename: M S
authors.initials: MS
authors.lastname: Vorob'eva
authors.forename: A S
authors.initials: AS
authors.lastname: Karavanov
authors.forename: V P
authors.initials: VP
authors.lastname: Grachev
authors.forename: I P
authors.initials: IP
authors.lastname: Ladyshenskaia
authors.forename: M N
authors.initials: MN
authors.lastname: Rasshchepkina
authors.forename: L N
authors.initials: LN
authors.lastname: Mel'nikova
authors.forename: T M
authors.initials: TM
authors.lastname: Lebedeva
authors.forename: N A
authors.initials: NA
authors.lastname: Mel'nikov
authors.forename: A G
authors.initials: AG
authors.lastname: Gusmanova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Deviatkov
authors.forename: E V
authors.initials: EV
authors.lastname: Rozanova
authors.forename: M A
authors.initials: MA
authors.lastname: Mukachev
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D000914:Antibodies, Viral / Q000097:blood; D001317:Austria; D002648:Child; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control*; D006801:Humans; D007114:Immunization / Q000379:methods* / Q000706:statistics & numerical data; D007117:Immunization, Secondary / Q000379:methods / Q000706:statistics & numerical data; D012426:Russia; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000009:adverse effects / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
vernacular_title: Izuchenie kul'tural'noĭ kontsentrirovannoĭ inaktivirovannoĭ vaktsiny protiv kleshchevogo éntsefalita pri immunizatsii deteĭ i podrostkov.