title: Use of infrared attenuated total reflectance spectroscopy for the in vivo measurement of hydration level and silicone distribution in the stratum corneum following skin coverage by polymeric dressings.
abstract: The ability of wound dressings to hydrate the stratum corneum has been tested experimentally using attenuated total reflectance (ATR) infrared spectroscopy. A silicone gel dressing was able to hydrate the stratum corneum to the extent that its water content within the sampled volume was >60% after 5 h of contact compared with about 15% of normal exposed skin and about 30% for a highly permeable hydrophilic polyurethane dressing. An ATR method was devised to determine the presence and depth of penetration of silicone in the stratum corneum as a result of skin coverage by the polymeric dressing.
authors.affiliation: Smith and Nephew Group Research Centre, York Science Park, Heslington, York, UK.
authors.forename: M
authors.initials: M
authors.lastname: Branagan
authors.forename: D H
authors.initials: DH
authors.lastname: Chenery
authors.forename: S
authors.initials: S
authors.lastname: Nicholson
mesh_terms: D000465:Algorithms; D001458:Bandages; D006801:Humans; D020034:Silicone Gels; D012828:Silicones / Q000032:analysis*; D012867:Skin / Q000737:chemistry* / Q000378:metabolism*; D012869:Skin Absorption; D013055:Spectrophotometry, Infrared; D013997:Time Factors; D014867:Water / Q000032:analysis*
chemical_list: D020034:Silicone Gels; D012828:Silicones; D014867:Water