Proton magnetic resonance spectroscopy of cerebrospinal fluid in neurodegenerative disease: indication of glial energy impairment in Huntington chorea, but not Parkinson disease.
Metabolite levels in cerebrospinal fluid from patients with Parkinson disease or Huntington chorea were compared with the levels in healthy controls using proton magnetic resonance spectroscopy. No significant differences were found for any metabolite measured in cerebrospinal fluid from patients with Parkinson disease compared to controls. Slight but significantly reduced levels of both lactate and citrate, however, were found in cerebrospinal fluid from patients with Huntington chorea compared to controls. This suggests possible impairment of both glycolysis and tricarboxylic acid cycle function. The reduction in lactate found in the present study may reflect neuronal loss. The decrease in citrate supports the theory of mitochondrial dysfunction in the brain of patients with Huntington chorea, but also suggests that there may be an important astrocytic component in this disease. If so, it would certainly have implications for neuronal function.
Gårseth
M
M
Department of Clinical Neuroscience, Section of Neurology, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Sonnewald
U
U
White
L R
LR
Rød
M
M
Zwart
J A
JA
Nygaard
O
O
Aasly
J
J
D000328:Adult; D000368:Aged; D019343:Citric Acid / Q000134:cerebrospinal fluid; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D019344:Lactic Acid / Q000134:cerebrospinal fluid; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000378:metabolism*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D011522:Protons; D012016:Reference Values
D011522:Protons; D019343:Citric Acid; D019344:Lactic Acid