Triplet-state photophysics of aluminium phthalocyanine sensitizer in murine cancer cells.
Diffuse-reflectance laser flash photolysis has been used to record transient spectra and decay kinetics of the photodynamic therapy sensitizer disulfonated aluminium phthalocyanine in two murine cancer cell lines, P815 derived from white mouse mast cells, and EL4, a lymphoblast derived from black mouse lymphocytes. In contrast to results with bacterial cells and yeasts, no transient other than the triplet state of the sensitizer was detected, suggesting that unlike the case in microbes, Type I electron-transfer processes play no role in the photodestruction of the murine cells studied.
Oldham
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Departrment of Chemistry, Imperial College of Science, Technology and Medicine, London, UK.
Phillips
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D000535:Aluminum; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D007211:Indoles / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D007700:Kinetics; D008223:Lymphoma; D012515:Mast-Cell Sarcoma; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009942:Organometallic Compounds / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D010782:Photolysis; D017319:Photosensitizing Agents / Q000493:pharmacokinetics; D014407:Tumor Cells, Cultured
D007211:Indoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C060570:aluminum phthalocyanine; D000535:Aluminum