title: [The immunological efficacy of one, two and three inoculations against diphtheria in adults].
abstract: The outbreak of diphtheria in the Republic of Belarus developed in the presence of a sharp deficiency of immunity among the population aged 35 years and over. In connection with a higher initial immunity level resulting from vaccination made in one injection the minimum antibody level (> or = 0.01 I.U./ml) was found in 79.7% of the examinees among the population under 35 years. For the age group of 35-60 years vaccination in one and two injections proved to be insufficiently effective (the minimum protective antibody titer was found, respectively, in 64.3% and 63.3% of the vaccinees). To achieve the full protection of this group of the population, vaccination in three injections was necessary; after that the minimum protective antibody titer was found in 90.7%, the protective antibody titer (0.1 I.U./ml) was found in 53.5% and the highly protective antibody titer (1.0 I.U./ml) was found in 11.6% of the examinees. The low level of highly protected persons among vaccinees receiving three injections was due to a low dose of diphtheria toxoid (2 Lf) in adsorbed DT-m vaccine with reduced antigen content.
authors.affiliation: Research Institute of Microbiology and Epidemiology, Minsk, Belarus.
authors.forename: V L
authors.initials: VL
authors.lastname: Kolodkina
authors.forename: E V
authors.initials: EV
authors.lastname: Fel'dman
authors.forename: A M
authors.initials: AM
authors.lastname: Dronina
authors.forename: L P
authors.initials: LP
authors.lastname: Titov
authors.forename: A K
authors.initials: AK
authors.lastname: Kozhemiakin
authors.forename: D F
authors.initials: DF
authors.lastname: Zakharenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D003353:Corynebacterium diphtheriae / Q000276:immunology; D004165:Diphtheria / Q000517:prevention & control; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology*; D022422:Diphtheria-Tetanus Vaccine; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007114:Immunization / Q000379:methods / Q000706:statistics & numerical data; D008875:Middle Aged; D012044:Regression Analysis; D002094:Republic of Belarus; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology*; D013997:Time Factors; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D013745:Tetanus Toxoid; D017778:Vaccines, Combined
vernacular_title: Immunologicheskaia éffektivnost' odnoĭ, dvukh i trekh privitok protiv difterii u vzroslykh.