Molecular determinants of presynaptic active zones.
The presynaptic cytoskeletal matrix (cytomatrix) assembled at active zones has been implicated in defining neurotransmitter release sites. Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins. These multidomain proteins are thought to organize the exocytotic and endocytotic machinery precisely at active zones.
Garner
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Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294-0021, USA. garner@nrc.uab.edu
Kindler
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Gundelfinger
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D000818:Animals; D004705:Endocytosis / Q000502:physiology; D005089:Exocytosis / Q000502:physiology; D009474:Neurons / Q000737:chemistry* / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000737:chemistry* / Q000378:metabolism*