title: Age and gender differences in body composition, energy expenditure, and glucoregulation of adult rhesus monkeys.
abstract: The purpose of this study was to examine the relationship of age to body composition, glucoregulation, activity, and energy expenditure in male and female rhesus monkeys. The animals were studied in three groups, young adults (YA, 7-9 years), middle-aged adults (MA, 13-17 years), and older adults (OA, > 23 years) adults. OA had a lower (P < 0.05) lean body mass than the YA and MA. OA also had the lowest values (P < 0.06) for energy expenditure (kJ/minute). Age-related differences (P < 0.05) were observed in time spent resting and moving. The OA spent the most time resting and the least time in vertical movement. There was a trend towards an age-related decrease in acute insulin response to glucose, while other glucoregulatory parameters were not changed with age. These results are similar to findings in humans, providing further evidence that the rhesus monkey is an appropriate model of human aging.
authors.affiliation: Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715-1299, USA. jramsey@primate.wisc.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Ramsey
authors.forename: J L
authors.initials: JL
authors.lastname: Laatsch
authors.forename: J W
authors.initials: JW
authors.lastname: Kemnitz
mesh_terms: D000367:Age Factors; D000818:Animals; D001823:Body Composition; D004734:Energy Metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D010101:Oxygen Consumption; D012737:Sex Factors
chemical_list: D005947:Glucose