Extracellular matrix components of the wall of umbilical cord vein and their alterations in pre-eclampsia.
Pre-eclampsia--edema, proteinuria, hypertension (EPH-gestosis) is one of the more common complications observed during pregnancy. The umbilical cord vein walls were taken from newborns delivered by healthy mothers (control material) and by mothers with polysymptomatic pre-eclampsia (investigated material). Normal saphenous vein walls were collected from adult subjects undergoing varicose vein surgery. The collagen content was measured by the assay of hydroxyproline. Elastin was determined according to Fastin Elastin Assay and gravimetrically. Glycosaminoglycans content was determined by uronic acids assay. The collagen content decreased in the pre-eclampsia material. The amount of soluble elastin increased in the investigated material. The insoluble elastin content decreased in the umbilical cord veins of newborns delivered by mothers with pre-eclampsia. Reconstructing the umbilical cord vein wall may disturb fetal blood flow and affect the vascular system in adulthood.
Romanowicz
L
L
Department of Biochemistry, Medical Academy of Białystok, Poland.
Sobolewski
K
K
D002809:Chondroitin Sulfates / Q000032:analysis; D003871:Dermatan Sulfate / Q000032:analysis; D004549:Elastin / Q000032:analysis; D005109:Extracellular Matrix / Q000737:chemistry*; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006493:Heparin / Q000032:analysis; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D007231:Infant, Newborn; D007632:Keratan Sulfate / Q000032:analysis; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D014471:Umbilical Veins / Q000737:chemistry* / Q000378:metabolism
D006025:Glycosaminoglycans; D003871:Dermatan Sulfate; D006820:Hyaluronic Acid; D006493:Heparin; D002809:Chondroitin Sulfates; D004549:Elastin; D007632:Keratan Sulfate; D006909:Hydroxyproline