title: EDIBLE: experimental design and information calculations in phylogenetics.
abstract: Although evolutionary inference from molecular sequences is a statistical problem, little attention has been paid to questions of experimental design. A computer program, EDIBLE, has been developed to perform likelihood calculations based on Markov process models of nucleotide substitution allied with phylogenetic trees, and from these to compute Fisher information measures under different experimental designs. These calculations can be used to answer questions of optimal experimental design in molecular phylogenetics.
  
  
  BACKGROUND
  Source code (ANSI C), executables and documentation for EDIBLE are available from http://ng-dec1.gen.cam. ac.uk/info/index.htmland 'downstream' Web pages.
  
  
  BACKGROUND
  N.Goldman@gen.cam.ac.uk
authors.affiliation: Department of Genetics, Downing Street, Cambridge CB2 3EH, UK.
authors.forename: T
authors.initials: T
authors.lastname: Massingham
authors.forename: N
authors.initials: N
authors.lastname: Goldman
mesh_terms: D016013:Likelihood Functions; D008390:Markov Chains; D010802:Phylogeny; D012984:Software