Genetic heterogeneity of Usher syndrome.
Progress towards the understanding of the molecular basis of US has been substantial. Nine different loci have been found to be responsible and two have had the specific gene identified. This information is expected to lay the foundation for the eventual development of new treatment strategies. Usher syndrome is the combined loss of both of humans most important two senses and a better understanding of the genes involved should not only help the families with US but will also provide much needed basic information about the hearing and visual systems.
Kimberling
W J
WJ
Boys Town National Research Hospital, Omaha, Nebr., USA.
Orten
D
D
Pieke-Dahl
S
S
D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D003638:Deafness / Q000453:epidemiology / Q000235:genetics*; D020233:Gait Disorders, Neurologic / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000453:epidemiology / Q000235:genetics*; D009218:Myosins / Q000235:genetics; D012174:Retinitis Pigmentosa / Q000453:epidemiology / Q000235:genetics*; D013577:Syndrome; D014481:United States / Q000453:epidemiology
D009218:Myosins