title: Intrauterine infection, magnesium sulfate exposure and cerebral palsy in infants born between 26 and 30 weeks of gestation.
abstract: OBJECTIVE
  To identify prenatal events associated with cerebral palsy (CP) in infants born between 26 and 30 weeks of gestation.
  
  
  METHODS
  Case (n=22)-control (n=170) study was performed using a logistic regression model.
  
  
  RESULTS
  Significant association of intrauterine infection with increased risk of CP was found in a logistic regression model that controlled for abnormal FHR patterns, placental infection, fetal acidosis at birth (umbilical artery pH<7. 1), and low Apgar score (<7) (odds ratio (OR) 5.47, 95% confidence interval (CI) 1.46-20.4). Magnesium sulfate exposure was associated with decreased risk (OR 0.13, CI 0.03-0.66) after exclusion of premature rupture of the membranes and abruptio placentae. In the magnesium exposure group, cases were infants born less than 28 weeks of gestation (3/21 vs. 0/61, P=0.015).
  
  
  CONCLUSIONS
  In this case-control study, both intrauterine infection and magnesium sulfate exposure were significant factors related to the occurrence of cerebral palsy.
authors.affiliation: Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan. ymatsuda@ml.kch.kagoshima.kagoshima.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: S
authors.initials: S
authors.lastname: Kouno
authors.forename: Y
authors.initials: Y
authors.lastname: Hiroyama
authors.forename: K
authors.initials: K
authors.lastname: Kuraya
authors.forename: M
authors.initials: M
authors.lastname: Kamitomo
authors.forename: S
authors.initials: S
authors.lastname: Ibara
authors.forename: M
authors.initials: M
authors.lastname: Hatae
mesh_terms: D000037:Abruptio Placentae / Q000150:complications; D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000209:etiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D016015:Logistic Models; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008423:Maternal Age; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D018566:Pregnancy, High-Risk; D012307:Risk Factors; D014591:Uterine Diseases / Q000150:complications*
chemical_list: D008278:Magnesium Sulfate