title: Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules.
abstract: An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency.
authors.affiliation: BioChem Pharma Inc., Laval, Québec, Canada. wangwu@biochempharma.com
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Préville
authors.forename: N
authors.initials: N
authors.lastname: Morin
authors.forename: S
authors.initials: S
authors.lastname: Mounir
authors.forename: W
authors.initials: W
authors.lastname: Cai
authors.forename: M A
authors.initials: MA
authors.lastname: Siddiqui
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D010619:Phenazines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D010619:Phenazines