The high production volume chemical challenge program: the relevance of the in vivo micronucleus assay.
The in vivo rodent bone marrow micronucleus assay (Mnt) has assumed a pivotal role in screening strategies for the identification of substances potentially carcinogenic to humans. The analysis of the results of the current international 5-year effort to provide toxicological data for high production volume chemicals will play a crucial role in developing future strategies for identifying health hazards. As part of that program, consideration is being given to accepting either in vitro genotoxicity data or results of the Mnt. The present analyses indicate that for hazard identification purposes that, in fact, in vitro genotoxicity test results, such as those derived from the Salmonella mutagenicity assay, may be an acceptable alternative.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA.
Cunningham
A R
AR
D000826:Animal Testing Alternatives; D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D016208:Databases, Factual; D015386:Hazardous Substances / Q000633:toxicity*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011237:Predictive Value of Tests; D013329:Structure-Activity Relationship
D002274:Carcinogens, Environmental; D015386:Hazardous Substances; D009153:Mutagens