[Liposome-incorporated interferon. The design of liposomal interferon].
To develop bound interferon, purified phospholipids (PL), obtained from waste products of soy-bean oil production, were chosen as lipid carries. The method for the development of the liposomal interferon complex was proposed. As shown in this study, with regard to the composition of the most significant PL fractions the carrier obtained from waste products of soy-bean processing proved to be more acceptable for humans than egg-yolk PL, traditionally used in practical liposomology. The advantage of the purified concentrate of waste products of soy-bean oil production was its greater affinity with the PL fraction profile of human internal organs (the liver, the kidneys) than the composition of PL of animal origin. The dispersion and stability of interferon-containing liposomes was evaluated. The interferon incorporation coefficient of soy-bean PL proved to exceed that of egg-yolk PL.
Kalenik
T N
TN
Far-Eastern State Academy of Economy and Management, State Medical University, Vladivostok, Russia.
Motavkina
N S
NS
Vorob'ev
A A
AA
D000818:Animals; D002645:Chickens; D004337:Drug Carriers; D015195:Drug Design; D004355:Drug Stability; D004530:Egg Yolk; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D008081:Liposomes / Q000737:chemistry; D010743:Phospholipids / Q000032:analysis; D013024:Soybean Oil; D013055:Spectrophotometry, Infrared
D004337:Drug Carriers; D008081:Liposomes; D010743:Phospholipids; D013024:Soybean Oil; D007372:Interferons
Interferon, deponirovannyĭ v liposomy. Konstruirovanie liposomal'nogo interferona.