title: Blood type and family cancer history in relation to precancerous gastric lesions.
abstract: BACKGROUND
  The increased odds of stomach cancer among subjects with blood type A have been reported in epidemiological studies.
  
  
  OBJECTIVE
  To study the relation of family history of gastric cancer and ABO blood type with precancerous gastric lesions in a high-risk area for stomach cancer. Subjects and setting We examined 3400 adults aged 35-64 in a population-based gastric endoscopic screening in a county in China with one of the highest rates of stomach cancer in the world.
  
  
  METHODS
  In this cross-sectional study, data on family cancer history, ABO blood type and other characteristics of the participants were obtained by interview and blood test. Responses were compared between those with the most advanced gastric lesions, dysplasia (DYS) or intestinal metaplasia (IM), versus those with chronic atrophic gastritis (CAG) or superficial gastritis (SG).
  
  
  RESULTS
  The prevalence odds ratio (OR) for blood type A relative to other types was 1.39 (95% CI : 1.12-1.73) for DYS and 1.28 (95% CI : 1.06-1.53) for IM. The OR associated with parental history of stomach cancer was 1.88 (95% CI : 1.20-2.95) for DYS, but the numbers were too small to evaluate aggregation among siblings. The combined OR associated with blood type A and a parental of history of gastric cancer was 2.61 (95% CI : 1.59-4.30) for DYS and 1.46 (95% CI : 0.93-2.31) for IM.
  
  
  CONCLUSIONS
  The findings suggest that genetic factors play a role in developing precancerous gastric lesions.
authors.affiliation: National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: W C
authors.initials: WC
authors.lastname: You
authors.forename: J L
authors.initials: JL
authors.lastname: Ma
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: M H
authors.initials: MH
authors.lastname: Gail
authors.forename: Y S
authors.initials: YS
authors.lastname: Chang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: Y R
authors.initials: YR
authors.lastname: Hu
authors.forename: J F
authors.initials: JF
authors.lastname: Fraumeni
authors.forename: G W
authors.initials: GW
authors.lastname: Xu
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D003430:Cross-Sectional Studies; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011230:Precancerous Conditions / Q000235:genetics*; D015995:Prevalence; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology
chemical_list: D000017:ABO Blood-Group System