Evolution: hox genes and the cellared wine principle.
Two Drosophila Hox genes involved in segmentation, fushi tarazu and bicoid, appear to have acquired these roles by functional divergence from classical homeotic genes. Recent results indicate how genes with critical functions in development can evolve completely different functions among species.
Gibson
G
G
Department of Genetics, North Carolina State University, Raleigh 27695-7614, USA. ggibson@unity.ncsu.edu
D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D019143:Evolution, Molecular; D051717:Fushi Tarazu Transcription Factors; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics
D029721:Drosophila Proteins; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D015534:Trans-Activators; C056478:bcd protein, Drosophila; C497169:ftz protein, Drosophila