Plasma cholesterol reduction by defatted soy ontjom (fermented with Neurospora intermedia) in rats fed a cholesterol-free diet.
To popularize defatted soy ontjom (DSB-ontjom, soy product fermented with Neurospora intermedia) as a new food, I examined the plasma cholesterol-reducing effects of DSB-ontjom and DSB in rats fed cholesterol-free diets and compared the efficiencies of these effects. DSB-ontjom greatly reduced the plasma cholesterol level and increased fecal steroid excretion as compared to DSB. DSB-ontjom was rich in pepsin-resistant protein having a high bile acid binding capacity and was abundant in isoflavone-aglycones, especially daizein. The dietary fiber (DF) of DSB-ontjom stimulated the production of short-chain fatty acids (SCFAs) by intestinal microflora. The effect of DSB-ontjom on plasma cholesterol reduction was attributed to the collaborative effects of pepsin-resistant-protein, isoflavone-aglycones and SCFA-producing DF in DSB-ontjom.
Matsuo
M
M
Faculty of General Education, Gifu Women's University, Japan.
D000818:Animals; D002352:Carrier Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000378:metabolism; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005285:Fermentation; D006913:Hydroxysteroid Dehydrogenases; D007422:Intestines / Q000382:microbiology*; D007529:Isoflavones / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins; D009491:Neurospora / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000378:metabolism / Q000627:therapeutic use*; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
D002352:Carrier Proteins; D002784:Cholesterol; D002791:Cholesterol, Dietary; D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D006913:Hydroxysteroid Dehydrogenases; D007529:Isoflavones; D008562:Membrane Glycoproteins; D030262:Soybean Proteins; C037643:bile acid binding proteins; C435496:AKR1C2 protein, human; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)