Evaluation of protein S-100 serum concentrations in healthy newborns and seven newborns with perinatal acidosis.
We measured Protein S-100 serum levels in 66 healthy newborns during the first week of life and in 7 newborns with perinatal acidosis. Normal values (n = 66) constantly ranged between 0.66 and 3.33 microg/l (2.5 and 97.5 percentiles) during the evaluation period.


CONCLUSIONS
Newborns with signs of hypoxic-ischaemic encephalopathy (HIE) after perinatal acidosis showed elevated Protein S-100 serum levels, whereas newborns without these signs had normal concentrations. S-100 might thus be a marker of central nervous system damage in newborns. Key words: Asphyxia, brain damage, neonate
Maschmann
J
J
Department of Neonatology University of Tuebingen, Germany. jens.maschmann@mail.uni-wuerzburg
Erb
Heinemann
M K
MK
Ziemer
G
G
Speer
C P
CP
D000138:Acidosis / Q000097:blood* / Q000150:complications; D001034:Apgar Score; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000209:etiology; D007231:Infant, Newborn; D011863:Radioimmunoassay; D009418:S100 Proteins / Q000097:blood*
D009418:S100 Proteins