title: Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary?
abstract: OBJECTIVE
  The objective of this study was to find readily ascertainable intraoperative pathologic indicators that would discriminate a subgroup of early corpus cancers that would not require lymphadenectomy or adjuvant radiotherapy.
  
  
  METHODS
  Between 1984 and 1993, a total of 328 patients with endometrioid corpus cancer, grade 1 or 2 tumor, myometrial invasion < or =50%, and no intraoperative evidence of macroscopic extrauterine spread were treated surgically. Pelvic lymphadenectomy was performed in 187 cases (57%), and nodes were positive in nine cases (5%). Adjuvant radiotherapy was administered to 65 patients (20%). Median follow-up was 88 months.
  
  
  RESULTS
  The 5-year overall cancer-related and recurrence-free survivals were 97% and 96%, respectively. Primary tumor diameter and lymphatic or vascular invasion significantly affected longevity. No patient with tumor diameter < or =2 cm had positive lymph nodes or died of disease.
  
  
  CONCLUSIONS
  Patients who have International Federation of Gynecology and Obstetrics grade 1 or 2 endometrioid corpus cancer with greatest surface dimension < or =2 cm, myometrial invasion < or =50%, and no intraoperative evidence of macroscopic disease can be treated optimally with hysterectomy only.
authors.affiliation: Department of Obstetrics and Gynecology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mariani
authors.forename: M J
authors.initials: MJ
authors.lastname: Webb
authors.forename: G L
authors.initials: GL
authors.lastname: Keeney
authors.forename: M G
authors.initials: MG
authors.lastname: Haddock
authors.forename: G
authors.initials: G
authors.lastname: Calori
authors.forename: K C
authors.initials: KC
authors.lastname: Podratz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009215:Myometrium / Q000473:pathology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D010388:Pelvis; D010537:Peritoneum / Q000473:pathology; D011183:Postoperative Complications; D011379:Prognosis; D011832:Radiation Injuries; D016019:Survival Analysis