Pilot study of IFN-gamma-induced specific hyposensitization for house dust mites in atopic dermatitis: IFN-gamma-induced immune deviation as a new therapeutic concept for atopic dermatitis.
IFN-gamma/IL-4 imbalance is a central immunologic defect which is responsible for increased IgE antibody response in atopic dermatitis. Effects of hyposensitization were controversial in atopic dermatitis. Reversed IFN-gamma/IL-4 balance was induced using IFN-gamma in atopic dermatitis and specific hyposensitization with house dust mites (HDM) was tried in the status of IFN-gamma-induced immune deviation. A total of 58 atopic dermatitis patients who had obvious allergy to HDM were selected in this study. IFN-gamma-induced hyposensitization for HDM was tried in 10 patients. Twenty-two patients received IFN-gamma therapy and six were treated by simple hyposensitization. Twenty were enrolled as control subjects. The clinical severity scores decreased effectively only by IFN-gamma-induced hyposensitization for HDM. Specific hyposensitization for HDM in the status of IFN-gamma-induced immune deviation successfully improved atopic dermatitis. HDM might play a pathogenic role in subpopulation of atopic dermatitis.
Noh
G
G
Department of Pediatrics, Sungkyunkwan University, School of Medicine, Seoul, Korea. atopyd@chollian.net
Lee
K Y
KY
D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D000818:Animals; D002469:Cell Separation; D002648:Child; D003876:Dermatitis, Atopic / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods; D004804:Eosinophils / Q000166:cytology / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000276:immunology / Q000627:therapeutic use*; D008297:Male; D008925:Mites / Q000276:immunology*; D010865:Pilot Projects
D000485:Allergens; D007073:Immunoglobulin E; D007371:Interferon-gamma