title: [Extra-pyramidal syndrome induced by donepezil].
abstract: BACKGROUND
  The cholinergic hypothesis of Alzheimer's disease is the basis of a new class of drugs: acetylcholinesterase inhibitors. These drugs have few side effects, mainly digestive disorders.
  
  
  METHODS
  Extra-pyramidal side effects with severe gait disorders were observed in 3 patients with Alzheimer's dementia treated with donepezil. This drug was associated with paroxetine or a neuroleptic. In 2 of the 3 cases, the extra-pyramidal effects disappeared when donepezil was discontinued.
  
  
  CONCLUSIONS
  Extra-pyramidal syndromes in elderly subjects with cognitive impairment are difficult to interpret. The possible causes include interactions between acetylcholinesterase inhibitors, neuroleptics and serotonine reuptake inhibitors and Lewy body dementia.
authors.affiliation: Hôpital de Jour d'Evaluation Gériatrique et Gérontologique Saint-François, CHUR de Strasbourg.
authors.forename: D
authors.initials: D
authors.lastname: Carcenac
authors.forename: C
authors.initials: C
authors.lastname: Martin-Hunyadi
authors.forename: M
authors.initials: M
authors.lastname: Kiesmann
authors.forename: C
authors.initials: C
authors.lastname: Demuynck-Roegel
authors.forename: M
authors.initials: M
authors.lastname: Alt
authors.forename: F
authors.initials: F
authors.lastname: Kuntzmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000077265:Donepezil; D005260:Female; D006801:Humans; D007189:Indans / Q000009:adverse effects* / Q000627:therapeutic use; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil
vernacular_title: Syndrome extrapyramidal sous donepezil.