title: Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography.
abstract: Few studies have examined the correlation between change in carotid artery intima-media thickness (IMT) and change in coronary artery disease. In the Cholesterol Lowering Atherosclerosis Study, current nonsmoking men with coronary artery disease were randomized to colestipol-niacin or placebo. Among 133 subjects with baseline and on-trial coronary angiography and carotid ultrasonography, colestipol-niacin treatment significantly reduced progression of atherosclerosis by both end point measures (2-year average change in percent diameter stenosis by coronary angiography and rate of change in carotid IMT). Significant correlations between change in common carotid artery IMT and quantitative coronary angiographic measures of change were evident over all coronary artery lesions, and in mild/moderate (<50% diameter stenosis), but not severe (>/=50% diameter stenosis) coronary artery lesions. In mild/moderate lesions, correlations with change in common carotid IMT were: percent diameter stenosis (r=0.28, P=0.002), minimum lumen diameter (r=-0.28, P=0.002), and vessel edge roughness (r=0.25, P=0.003). While measures obtained by carotid ultrasonography and coronary angiography are correlated, they each assess different aspects of atherosclerosis change.
authors.affiliation: Atherosclerosis Research Unit, University of Southern California, Los Angeles, CA, USA. wmack@rcf.usc.edu
authors.forename: W J
authors.initials: WJ
authors.lastname: Mack
authors.forename: L
authors.initials: L
authors.lastname: LaBree
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: R H
authors.initials: RH
authors.lastname: Selzer
authors.forename: H N
authors.initials: HN
authors.lastname: Hodis
mesh_terms: D000328:Adult; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging*; D016893:Carotid Stenosis / Q000097:blood / Q000000981:diagnostic imaging* / Q000517:prevention & control; D003084:Colestipol / Q000627:therapeutic use; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000517:prevention & control; D018450:Disease Progression; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use; D015588:Observer Variation; D011379:Prognosis; D015203:Reproducibility of Results; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography; D014741:Video Recording
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D009525:Niacin; D003084:Colestipol