title: Elevated urinary albumin excretion is not linked to the angiotensin I-converting enzyme gene polymorphism in clinically healthy subjects.
abstract: An elevated urinary albumin excretion (UAE) in non-diabetic subjects without renal or cardiovascular disease has been shown to be predictive of ischaemic heart disease. An insertion (I)/deletion (D) polymorphism in the angiotensin I-converting enzyme (ACE) gene has been identified and the D allele may be associated with cardiovascular disease. The aim of this study was to find a potential linkage between this polymorphism and elevated UAE. For studies of UAE and cardiovascular pathophysiology, a highly selected population sample has been identified comprising all clinically healthy subjects aged 40-65 years with elevated UAE in a dipstick negative urinary sample (n = 27) from The Copenhagen City Heart Study. Neither the ACE genotype distribution (p = 0.12) nor the D and I allele frequencies (p = 0.69) differed significantly between subjects with elevated UAE and a matched normoalbuminuric control group (n = 46). Elevated UAE in clinically healthy subjects is not linked to the ACE gene polymorphism.
authors.affiliation: Medical Department P, State University Hospital, Copenhagen, Denmark. pclausen@rh.dk
authors.forename: P
authors.initials: P
authors.lastname: Clausen
authors.forename: J S
authors.initials: JS
authors.lastname: Jensen
authors.forename: K
authors.initials: K
authors.lastname: Borch-Johnsen
authors.forename: G
authors.initials: G
authors.lastname: Jensen
authors.forename: B
authors.initials: B
authors.lastname: Feldt-Rasmussen
mesh_terms: D000419:Albuminuria / Q000235:genetics* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A