title: Triple-dose contrast-enhanced images in neurologically symptomatic HIV-positive patients.
abstract: Our purpose was to determine whether triple-dose delayed contrast-enhanced images would improve lesion detection in patients with symptomatic human immunodeficiency virus (HIV) infection. We reviewed 33 MRI studies on 29 patients. Single-dose immediate T1-weighted spin-echo (1x-T1) images were compared with delayed triple-dose images (D3x-T1). Two neuroradiologists decided which technique showed more lesions, increased lesion conspicuity and/or altered the radiologic diagnosis. The D3x-T1 technique improved lesion detection in 14 of 29 patients (48%). In two patients (7%), the improvement changed the radiologic diagnosis by showing new meningeal lesions.
authors.affiliation: Baylor College of Medicine, Department of Radiology, Houston, TX 77030-3498, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Diaz-Marchan
authors.forename: M L
authors.initials: ML
authors.lastname: Huang
authors.forename: E F
authors.initials: EF
authors.lastname: Jackson
authors.forename: R E
authors.initials: RE
authors.lastname: Norton
authors.forename: L A
authors.initials: LA
authors.lastname: Hayman
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D003287:Contrast Media