Triple-dose contrast-enhanced images in neurologically symptomatic HIV-positive patients.
Our purpose was to determine whether triple-dose delayed contrast-enhanced images would improve lesion detection in patients with symptomatic human immunodeficiency virus (HIV) infection. We reviewed 33 MRI studies on 29 patients. Single-dose immediate T1-weighted spin-echo (1x-T1) images were compared with delayed triple-dose images (D3x-T1). Two neuroradiologists decided which technique showed more lesions, increased lesion conspicuity and/or altered the radiologic diagnosis. The D3x-T1 technique improved lesion detection in 14 of 29 patients (48%). In two patients (7%), the improvement changed the radiologic diagnosis by showing new meningeal lesions.
Diaz-Marchan
P J
PJ
Baylor College of Medicine, Department of Radiology, Houston, TX 77030-3498, USA.
Huang
M L
ML
Jackson
E F
EF
Norton
R E
RE
Hayman
L A
LA
D000328:Adult; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology / Q000821:virology; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D011446:Prospective Studies
D003287:Contrast Media