[The action of its own antibiotic on the producer of imbricin growing on an agarized medium].
The action of imbricin on its own producer Streptomyces imbricatus grown on an agarized medium was studied. Comparatively low concentrations of the antibiotic were shown to have a high lethal action on the streptomycete. The morphological and cultural features of S. imbricatus did not change under the action of imbricin while the variation with respect to the antibiotic production property markedly increased. After the strain exposure to 200 micrograms/ml of imbricin, a stable variant with the antibiotic potency 20 per cent higher than that of the initial organism was isolated.
Gorbunova
N A
NA
St. Petersburg State Chemico-Pharmaceutical Academy.
Iakovleva
E P
EP
D000362:Agar; D000935:Antifungal Agents / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology*; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D014644:Genetic Variation / Q000187:drug effects / Q000502:physiology; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000187:drug effects* / Q000254:growth & development; D013997:Time Factors
D000935:Antifungal Agents; D003470:Culture Media; D000362:Agar
Deĭstvie sobstvennogo antibiotika na produtsent imbritsina pri vyrashchivanii na agarizovannoĭ srede.