Effect of Septilin--a herbal preparation on pharmacokinetics of carbamazepine in rabbits.
The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-administration of Septilin. We conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.
Garg
S K
SK
Department of Pharmacology, Postgraduate Institute Of Medical Education and Research, Chandigarh.
Islam
A S
AS
Kumar
N
N
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics*; D002220:Carbamazepine / Q000097:blood / Q000493:pharmacokinetics*; D004347:Drug Interactions; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics / Q000494:pharmacology*; D011817:Rabbits
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D010936:Plant Extracts; C047352:septilin; D002220:Carbamazepine