title: CT in the selection of patients with abdominal or pelvic sarcoma for reoperative surgery.
abstract: BACKGROUND
  Retroperitoneal or visceral sarcoma may recur with disease limited to the abdomen and pelvis. In this clinical situation, further surgical treatments in an attempt to control the disease may be appropriate. CT is used to help select patients for additional surgical interventions.
  
  
  METHODS
  Preoperative abdominal and pelvic CT scans of 33 patients with recurrent sarcoma were reviewed retrospectively. All patients underwent reoperative surgery and, when appropriate, perioperative intraperitoneal chemotherapy. Patients were divided into two groups according to survival and disease status: alive with no evidence of disease (n = 7) and alive with disease or dead of disease (n = 26). Twenty-two CT indices were studied retrospectively for each patient and evaluated statistically.
  
  
  RESULTS
  The presence of large (greater than 5 cm) tumor volume in 3 of the 13 abdominopelvic regions resulted in a significant difference in the prognosis between the groups of patients. These findings included tumor in the left lower quadrant (p = 0.032), tumor in the pelvis (p = 0.008), and tumor in the distal jejunum (p = 0.032). Two other CT indices that showed a significant difference in survival between the groups were involvement of five abdominopelvic regions or fewer (p = 0.008) and a peritoneal cancer index of 15 or less (p = 0.03). A statistical approach using a tree-structured diagram showed that patients with tumor diameter greater than 5 cm in the pelvis accompanied by tumor involvement of more than one segment of small bowel had a 0% probability of postoperative disease-free survival. In contrast, patients with tumor diameter less than 5 cm in the pelvis on CT had an 86% probability of disease-free survival.
  
  
  CONCLUSIONS
  For patients with recurrent sarcoma, selection criteria were generated by a preoperative CT of the abdomen and pelvis. In this disease, CT was a reliable diagnostic test for predicting benefit from further surgical interventions and should be used in the future to help select patients for an aggressive versus a palliative approach.
authors.affiliation: The Washington Cancer Institute, Washington Hospital Center, DC 20010, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Pestieau
authors.forename: J S
authors.initials: JS
authors.lastname: Jelinek
authors.forename: D
authors.initials: D
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: Jacquet
authors.forename: P H
authors.initials: PH
authors.lastname: Sugarbaker
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D010386:Pelvic Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D011300:Preoperative Care; D012086:Reoperation; D012189:Retrospective Studies; D012509:Sarcoma / Q000000981:diagnostic imaging* / Q000401:mortality / Q000601:surgery*; D014057:Tomography, X-Ray Computed