title: Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia.
abstract: Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical circuits that adaptively regulate sympathetic and cardiovascular activities.
authors.affiliation: Department of Medicine, Pulmonary and Critical Care Division, Long Island Jewish, Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA. asica@snet.net
authors.forename: A L
authors.initials: AL
authors.lastname: Sica
authors.forename: H E
authors.initials: HE
authors.lastname: Greenberg
authors.forename: S M
authors.initials: SM
authors.lastname: Scharf
authors.forename: D A
authors.initials: DA
authors.lastname: Ruggiero
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D002908:Chronic Disease; D015870:Gene Expression / Q000502:physiology; D017781:Genes, Immediate-Early / Q000502:physiology*; D006179:Gyrus Cinguli / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology*; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016760:Proto-Oncogene Proteins c-fos