title: Rational manipulation of oxygen delivery.
abstract: BACKGROUND
  Optimization of oxygen delivery remains the best method to prevent and the only way to treat common intensive care unit syndromes such as sepsis, multiple organ dysfunction, and acute lung injury. This paper reviews the elements of oxygen delivery, describes how clinical interventions work through those elements to alter oxygen delivery, reviews theoretical and empirical data relating to manipulation of each element, and distinguishes between therapeutic means and clinical endpoints in the care of the critically ill.
  
  
  METHODS
  Recent literature is reviewed. Relevant equations are detailed. Computer models and patient data illustrate key points.
  
  
  RESULTS
  Clinical interventions intended to improve oxygen delivery all work through at least one of seven variables (oxygen saturation, hemoglobin concentration, heart rate, mean arterial blood pressure, systemic vascular resistance, end-diastolic volume, and ejection fraction). Because interventions that increase oxygen delivery are always accompanied by physiologic costs, cavalier application of any therapy in the intensive care unit may actually decrease oxygen delivery, harming the critically ill patient. Various clinical indicators may be used as endpoints to guide therapy.
  
  
  CONCLUSIONS
  While a systematic consideration of the elements of oxygen delivery reveals weaknesses in experimental evidence guiding optimal treatment of shock, reasonable strategies as well as avoidable pitfalls emerge from the data. Furthermore, facility with each of the elements of oxygen delivery makes ICU management easier to teach and to apply.
authors.affiliation: UCLA Division of General Surgery, Los Angeles, California 90095, USA.
authors.forename: T
authors.initials: T
authors.lastname: Blinman
authors.forename: M
authors.initials: M
authors.lastname: Maggard
mesh_terms: D000208:Acute Disease / Q000628:therapy*; D003422:Critical Care / Q000379:methods*; D006801:Humans; D010102:Oxygen Inhalation Therapy / Q000379:methods*