title: HIF-1 is essential for multilineage hematopoiesis in the embryo.
authors.affiliation: Department of Pathology, University of Chicago, IL 60637, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Adelman
authors.forename: E
authors.initials: E
authors.lastname: Maltepe
authors.forename: M C
authors.initials: MC
authors.lastname: Simon
mesh_terms: D000818:Animals; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator; D015687:Cell Hypoxia / Q000235:genetics / Q000502:physiology; D002678:Chimera; D003114:Colony-Forming Units Assay; D016207:Cytokines / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D016228:Endothelial Growth Factors / Q000494:pharmacology; D005260:Female; D005311:Fetal Hypoxia / Q000235:genetics / Q000503:physiopathology; D006410:Hematopoiesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D066298:In Vitro Techniques; D008222:Lymphokines / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy; D018336:Receptors, Aryl Hydrocarbon; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D015017:Yolk Sac / Q000166:cytology
chemical_list: C497397:Arnt protein, mouse; D016207:Cytokines; D004268:DNA-Binding Proteins; D016228:Endothelial Growth Factors; C497443:Hif1a protein, mouse; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines; D009687:Nuclear Proteins; D018336:Receptors, Aryl Hydrocarbon; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D051784:Aryl Hydrocarbon Receptor Nuclear Translocator