Methaqualone derivatives are potent noncompetitive AMPA receptor antagonists.
Quinazolin-4-one derivatives of methaqualone substituted at C-2 define a new class of noncompetitive antagonists at AMPA receptors.
Chenard
B L
BL
Central Research Division, Pfizer Inc., Groton, CT 06340, USA. chenab@pfizer.com
Menniti
F S
FS
Pagnozzi
M J
MJ
Shenk
K D
KD
Ewing
F E
FE
Welch
W M
WM
D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000187:drug effects / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology; D008702:Methaqualone / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*
D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D008702:Methaqualone