title: [Effect of the mutation process on formation of alkaloids in Penicillium roquefortii BKM F-141 and P. fellutanum BKM F-1073].
abstract: Mutant strains of Penicillium roquefortii VKM F-141 and P. Fellutanum VKM F-1073 were obtained by mutagenesis induced by ultraviolet irradiation, N-methyl-N-nitronitrosoguanidine and bromouracil. By the rates of alkaloid production, the mutant strains can be divided into three groups: 1) unable to synthesize alkaloids; 2) with a high rate of biosynthesis; 3) with changed alkaloid composition. Compounds not characteristic of wild-type cultures were found in alkaloid fractions of some mutant strains.
authors.affiliation: G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow oblast, Russia.
authors.forename: I G
authors.initials: IG
authors.lastname: Buzilova
authors.forename: D M
authors.initials: DM
authors.lastname: Boĭchenko
authors.forename: L V
authors.initials: LV
authors.lastname: Boĭchenko
authors.forename: N F
authors.initials: NF
authors.lastname: Zelenkova
authors.forename: M U
authors.initials: MU
authors.lastname: Arinbasarov
authors.forename: B P
authors.initials: BP
authors.lastname: Baskunov
authors.forename: T A
authors.initials: TA
authors.lastname: Reshetilova
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis*; D001976:Bromouracil / Q000494:pharmacology; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D016296:Mutagenesis; D009154:Mutation; D010407:Penicillium / Q000187:drug effects / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D013045:Species Specificity; D014466:Ultraviolet Rays
chemical_list: D000470:Alkaloids; D008769:Methylnitronitrosoguanidine; D001976:Bromouracil
vernacular_title: Vliianie mutatsionnogo protsessa na obrazovanie alkaloidov u Penicillium roquefortii BKM F-141 i P. fellutanum BKM F-1073.