title: Subhypnotic dose of propofol for the prevention of nausea and vomiting during spinal anaesthesia for caesarean section.
abstract: This study was undertaken to evaluate the efficacy of subhypnotic doses of propofol for the prevention of nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia. In a randomized, double-blinded, placebo-controlled manner, 60 patients received intravenously lignocaine 0.1 mg/kg (for injection pain relief) followed by either placebo (Intralipid) or propofol at subhypnotic dose (1.0 mg/kg/h) (n = 30 of each) immediately after clamping of the fetal umbilical cord. Emetic episodes and safety assessments were performed during spinal anesthesia for caesarean section. The incidence of patients who were emesis-free in the intraoperative, post-delivery period was 37% with placebo and 77% with propofol, respectively (P = 0.001). No clinically important adverse events were observed in either group. In conclusion, a subhypnotic dose (1.0 mg/kg/h) of propofol is effective for preventing nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia.
authors.affiliation: Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Numazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Fujii
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage; D000932:Antiemetics / Q000627:therapeutic use; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007430:Intraoperative Care; D008012:Lidocaine / Q000008:administration & dosage; D008787:Metoclopramide / Q000627:therapeutic use; D010919:Placebos; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D012449:Safety
chemical_list: D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D000932:Antiemetics; D010919:Placebos; D008012:Lidocaine; D008787:Metoclopramide; D015742:Propofol