title: The role of preoperative chemotherapy in the treatment of infantile fibrosarcoma.
abstract: Infantile fibrosarcoma (IFS) is a rare tumor most often affecting the extremities of infants and young children. Unlike its adult counterpart, IFS has a low potential for metastatic spread, and surgical extirpation alone has therefore resulted in an excellent prognosis. The amputation rate, however, exceeds 50%. The dramatic response in 2 recent cases to preoperative chemotherapy, given in an attempt to avoid amputation, prompted this report and a review of the literature.
authors.affiliation: Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, Providence, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Kurkchubasche
authors.forename: E G
authors.initials: EG
authors.lastname: Halvorson
authors.forename: E N
authors.initials: EN
authors.lastname: Forman
authors.forename: R M
authors.initials: RM
authors.lastname: Terek
authors.forename: W S
authors.initials: WS
authors.lastname: Ferguson
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001132:Arm; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005354:Fibrosarcoma / Q000151:congenital* / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide