title: NABC1 (BCAS1): alternative splicing and downregulation in colorectal tumors.
abstract: We have identified a new splicing variant of the gene "novel amplified in breast cancer 1," NABC1 (HGMW-approved symbol BCAS1). This variant, which we call NABC1_5B, uses a previously unidentified 135-bp exon. Also in this report, we confirm that NABC1 is overexpressed in breast tumors and show that both NABC1 and NABC1_5B are downregulated in colorectal tumors.
authors.affiliation: Ludwig Institute for Cancer Research, São Paulo, Brazil.
authors.forename: R G
authors.initials: RG
authors.lastname: Correa
authors.forename: A F
authors.initials: AF
authors.lastname: de Carvalho
authors.forename: N A
authors.initials: NA
authors.lastname: Pinheiro
authors.forename: A J
authors.initials: AJ
authors.lastname: Simpson
authors.forename: S J
authors.initials: SJ
authors.lastname: de Souza
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D001940:Breast / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism; D015536:Down-Regulation; D020224:Expressed Sequence Tags; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012007:Rectum / Q000378:metabolism
chemical_list: C113699:BCAS1 protein, human; D009363:Neoplasm Proteins