title: A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.
abstract: A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore was synthesized and evaluated as a potential antitumor agent. Cell cycle analysis with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. Herein described is the SAR summary of the substituent patterns on this pharmacophore template.
authors.affiliation: Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan. t-owa@hhc.eisai.co.jp
authors.forename: T
authors.initials: T
authors.lastname: Owa
authors.forename: T
authors.initials: T
authors.lastname: Okauchi
authors.forename: K
authors.initials: K
authors.lastname: Yoshimatsu
authors.forename: N H
authors.initials: NH
authors.lastname: Sugi
authors.forename: Y
authors.initials: Y
authors.lastname: Ozawa
authors.forename: T
authors.initials: T
authors.lastname: Nagasu
authors.forename: N
authors.initials: N
authors.lastname: Koyanagi
authors.forename: T
authors.initials: T
authors.lastname: Okabe
authors.forename: K
authors.initials: K
authors.lastname: Kitoh
authors.forename: H
authors.initials: H
authors.lastname: Yoshino
mesh_terms: D002453:Cell Cycle / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013449:Sulfonamides / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D013449:Sulfonamides