Homer: a link between neural activity and glutamate receptor function.
The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins. Homer proteins also self associate and function as adaptors to couple interacting proteins. Recent observations indicate a role for Homer complexes in signal transduction, synaptogenesis and receptor trafficking.
Xiao
B
B
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tu
J C
JC
Worley
P F
PF
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D000072233:Homer Scaffolding Proteins; D006801:Humans; D009474:Neurons / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology*; D017470:Receptors, Glutamate / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D009479:Neuropeptides; D017470:Receptors, Glutamate