Adverse effects of paclitaxel in patients with alcohol abuse histories.
Paclitaxel is a taxane antineoplastic agent formulated in polyoxyethylated castor oil (Cremophor El) and dehydrated alcohol. This case report describes the development of central nervous system toxicity and threatened sobriety related to the alcohol content in a paclitaxel infusion. Nurses need to be aware of the alcohol contained in paclitaxel and other drugs used in oncology practice and document previous and current alcohol use prior to beginning therapy. Alternative chemotherapy regimens may need to be offered to patients with alcohol abuse histories.
Henderson-Martin
B
B
D000437:Alcoholism / Q000150:complications*; D000438:Alcohols / Q000009:adverse effects / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000737:chemistry; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000188:drug therapy* / Q000451:nursing; D002626:Chemistry, Pharmaceutical; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000451:nursing; D008297:Male; D008875:Middle Aged; D009859:Oncology Nursing / Q000379:methods; D017239:Paclitaxel / Q000009:adverse effects* / Q000737:chemistry
D000438:Alcohols; D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel