[The effect of protoplast formation on the antibiotic activity and composition of the actinomycin complex in a strain of Streptomyces galbus (F) subsp. achromogenes 695 and in its active variants].
Protoplasting and regeneration promoted variation by the antibiotic production property in Streptomyces galbus (F) subsp. achromogenes 695 and its active variants 695-3-2 and 695-3-2-206. Variant 695-P24 with the potency 2 times higher than that of the initial strain 695 revertants was selected. No variants lacking the capacity for biosynthesis of the main components of antibiotic A-695 were detected among the revertants still, protoplasting of strains 695-3-2-206 and 695-P24 resulted in formation of variants synthesizing new components of the actinomycin complex.
Iocheva
L D
LD
Faculty of Biology, St. Kl. Ochridsky Sofia University, Bulgaria.
Antonova-Nikolova
S K
SK
D000900:Anti-Bacterial Agents / Q000032:analysis / Q000096:biosynthesis*; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000096:biosynthesis*; D002855:Chromatography, Thin Layer; D003609:Dactinomycin / Q000032:analysis / Q000096:biosynthesis*; D014644:Genetic Variation / Q000502:physiology*; D011523:Protoplasts / Q000737:chemistry / Q000502:physiology*; D012038:Regeneration / Q000502:physiology; D013053:Spectrophotometry; D013302:Streptomyces / Q000737:chemistry / Q000502:physiology*
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D003609:Dactinomycin
Vliianie protoplastirovaniia na antibioticheskuiu aktivnost' i sostav aktinomitsinovogo kompleksa shtamma Streptomyces galbus (F) subsp. achromogenes 695 i ego aktivnykh variantov.