title: Heterogeneity in Paget disease of the bone.
abstract: Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease gene in this pedigree is not linked to the region on 18q, thus confirming linkage heterogeneity.
authors.affiliation: Park Nicollet Clinic and Department of Neurology, Hennepin County Medical Center, Minneapolis, MN, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Nance
authors.forename: F Q
authors.initials: FQ
authors.lastname: Nuttall
authors.forename: M J
authors.initials: MJ
authors.lastname: Econs
authors.forename: K W
authors.initials: KW
authors.lastname: Lyles
authors.forename: K D
authors.initials: KD
authors.lastname: Viles
authors.forename: J M
authors.initials: JM
authors.lastname: Vance
authors.forename: M A
authors.initials: MA
authors.lastname: Pericak-Vance
authors.forename: M C
authors.initials: MC
authors.lastname: Speer
mesh_terms: D000328:Adult; D000368:Aged; D002887:Chromosomes, Human, Pair 18; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000235:genetics*; D010375:Pedigree