Acute optic neuropathy and transverse myelopathy in patients with antiphospholipid antibody syndrome: favorable outcome after treatment with anticoagulants and glucocorticoids.
We describe two patients with established antiphospholipid syndrome, who during periods of subtherapeutic anticoagulation, developed acute optic neuropathy and transverse myelopathy. Treatment with optimal anticoagulation and high dose glucocorticoids was followed by resolution of the neurologic deficits.
Aziz
A
A
Department of Medicine, Louisiana State University Medical Center, New Orleans, USA.
Conway
M D
MD
Robertson
H J
HJ
Espinoza
L R
LR
Wilson
W A
WA
D000208:Acute Disease; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009901:Optic Nerve Diseases / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000188:drug therapy; D013118:Spinal Cord Diseases / Q000209:etiology*; D014859:Warfarin / Q000627:therapeutic use*
D000925:Anticoagulants; D005938:Glucocorticoids; D014859:Warfarin