Polyoxygenated bipyridine, pyrrolylpyridine, and bipyrrole alkaloids from Speranskia tuberculata.
Five novel polyoxygenated alkaloids, speranculatines A-C (3-5), speranskilatine A (6), and speranberculatine A (7), have been isolated from Speranskia tuberculata. Compounds 3-5, 6, and 7, have bipyridine, pyrrolylpyridine, and bipyrrole skeletons, respectively. This is the first time that these three alkaloid structural types have been reported. The structures of 3-7 were elucidated by spectroscopic methods, including 2D NMR techniques and X-ray crystallographic analysis.
Shi
J G
JG
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100050, People's Republic of China. shijiangong@263.net
Wang
H Q
HQ
Wang
M
M
Yang
Y C
YC
Hu
W Y
WY
Zhou
G X
GX
D000470:Alkaloids / Q000737:chemistry*; D019665:Euphorbiaceae / Q000737:chemistry*; D005583:Fourier Analysis; D008958:Models, Molecular; D011725:Pyridines / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014961:X-Ray Diffraction
D000470:Alkaloids; D011725:Pyridines; D011758:Pyrroles