title: How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies.
abstract: The epsilon 4 allele of apolipoprotein E is a risk factor for Alzheimer's disease, but also a modulator of its clinical picture. In this paper, recent research in neuroimaging of aging and Alzheimer's disease in relation to apolipoprotein E is reviewed, emphasizing the advances but also the controversies. Further, the possible clinicopathological implications of these findings are discussed.
authors.affiliation: Department of Neurology, Kuopio University Hospital, P.O. Box 1777, 70211, Kuopio, Finland. maarit.lehtovirta@ktl.fi
authors.forename: M
authors.initials: M
authors.lastname: Lehtovirta
authors.forename: M P
authors.initials: MP
authors.lastname: Laakso
authors.forename: G B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: H
authors.initials: H
authors.lastname: Soininen
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000502:physiology*; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D011877:Radionuclide Imaging
chemical_list: D001057:Apolipoproteins E