title: The compatibility and stability of octreotide acetate in the presence of diamorphine hydrochloride in polypropylene syringes.
abstract: Varying concentrations of octreotide acetate (Sandostatin) and diamorphine hydrochloride were prepared and stored in polypropylene syringes at 37 degrees C in the dark. The solutions were analysed for octreotide acetate content using a validated HPLC method at regular intervals over a 48-h period. The results indicate that octreotide acetate remains stable in the presence of diamorphine hydrochloride at 37 degrees C for 24 h. In addition, the solutions prepared maintained their clarity, with no signs of precipitation upon visual examination under normal light conditions.
authors.affiliation: Western General Hospital, Edinburgh.
authors.forename: H
authors.initials: H
authors.lastname: Fielding
authors.forename: N
authors.initials: N
authors.lastname: Kyaterekera
authors.forename: G G
authors.initials: GG
authors.lastname: Skellern
authors.forename: J N
authors.initials: JN
authors.lastname: Tettey
authors.forename: J R
authors.initials: JR
authors.lastname: McDade
authors.forename: Z
authors.initials: Z
authors.lastname: Msuya
authors.forename: D G
authors.initials: DG
authors.lastname: Watson
authors.forename: J
authors.initials: J
authors.lastname: Urie
mesh_terms: D000701:Analgesics, Opioid / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D004356:Drug Storage; D005765:Gastrointestinal Agents / Q000737:chemistry*; D003932:Heroin / Q000737:chemistry*; D006801:Humans; D015282:Octreotide / Q000737:chemistry*; D010166:Palliative Care; D013594:Syringes
chemical_list: D000701:Analgesics, Opioid; D004338:Drug Combinations; D005765:Gastrointestinal Agents; D003932:Heroin; D015282:Octreotide