[Management of infertility following treatment of testicular tumors].
Testis cancer mainly affects patients in a reproductive age. Since at the present time recovery can be achieved in 84% of cases within ten years, there has been an increasing demand for paternity by these patients. In most cases, the preventive cryopreservation of spermatozoa and their subsequent use for assisted reproductive techniques can solve the problems connected with secretory infertility (no always reversible) caused by chemotherapy or radiotherapeutic treatment. Cryopreservation also allows to avoid the surgical taking of germinal cells either from testes or from seminal ducts in cases of anajeculation due to retroperineal lymphoadenectomy (present in 23.5-80% of cases). Failing the preventive cryopreservation, the surgical or microsurgical extraction of testis spermatozoa can be performed with success rates equal to 50%. Their use for intracytoplasmic sperm injection (ICSI) procedures presently seems to provide some encouraging results both for fertilization and pregnancy rates.
Colpi
G M
GM
Servizio di Andrologia, Ospedale S. Paolo, Milano.
Grugnetti
C
C
Mancini
M
M
D000970:Antineoplastic Agents / Q000009:adverse effects; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000209:etiology*; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D011247:Pregnancy / Q000706:statistics & numerical data; D011878:Radiotherapy / Q000009:adverse effects; D013094:Spermatozoa; D013736:Testicular Neoplasms / Q000628:therapy*
D000970:Antineoplastic Agents
Gestione dell'infertilità conseguente a trattamento per tumore del testicolo.