[Comparison between penicillin and amoxicillin-clavulanic acid for the treatment of recurrent tonsillopharyngitis in childhood].
Fifty-one children aged 2-14 years with recurrent tonsillopharyngitis, presenting dysphagia, fever and lymphadenitis, with more than two similar episodes in the last three years and showing a beta-hemolytic group A streptococci in the pharyngeal smear, were studied. They underwent random treatment for ten days with phenoxymethylpenicillin (40-60 mg/kg/day) (n = 28) or amoxicillin-clavulanic acid (20-40 mg/kg/day) (n = 23) taken orally three times a day. Clinical and bacteriological tests were carried out at 10 days and 2, 6 and 12 months post-treatment. The clinical and bacteriological results showed the superiority of the amoxicillin-clavulanic acid treatment both in the short term (disappearance of symptoms) and in the long term (decrease in recurrence). These results support the idea that betalactamases produced by the pharyngeal flora play an important role in the failures of penicillin.
Asensi
F
F
Servicios de Pediatría y Microbiología Clínica, Hospital Universitario La Fe, Avda. Campanar 21, 46009 Valencia.
López-Hontangas
J L
JL
Otero
M
M
Santos
M
M
Román
J
J
Pérez-Tamarit
D
D
D000293:Adolescent; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D006801:Humans; D010404:Penicillin V / Q000627:therapeutic use*; D010406:Penicillins / Q000627:therapeutic use*; D010612:Pharyngitis / Q000188:drug therapy*; D011446:Prospective Studies; D014069:Tonsillitis / Q000188:drug therapy*
D010406:Penicillins; D019980:Amoxicillin-Potassium Clavulanate Combination; D010404:Penicillin V
Comparación entre penicilina y amoxicilina-acido clavulánico para el tratamiento de la faringoamigdalitis recurrente en la infancia.