[The relationship of Helicobacter pylori to iron status--serum ferritin and hemoglobin. A seroepidemiologic survey of 2794 Danes].
We evaluated the influence of Helicobacter pylori (H. pylori) infection assessed by the levels of H. pylori serum IgG-antibodies, on iron status (serum ferritin and haemoglobin) in 2794 Danes (1425 men), aged 30-60 years. The seroprevalence of H. pylori antibodies increased with age (p < 0.01). Median serum ferritin levels were significantly lower in seropositive than in seronegative men and postmenopausal women (men 114 micrograms/L vs. 120 micrograms/L, p = 0.01; premenopausal women 37 micrograms/L vs. 40 micrograms/L, p = 0.13; postmenopausal women 63 micrograms/L vs. 77 micrograms/L, p = 0.02). Seropositive subjects had a higher prevalence of iron deficiency (serum ferritin < 15 micrograms/L) than seronegative subjects. H. pylori infection has a negative influence on iron status. We hypothesize that this may be caused by increased blood losses from the gastric mucosa.
Milman
N
N
Medicinsk afdeling, Centralsygehuset i Naestved.
Rosenstock
S J
SJ
Andersen
L P
LP
Jørgensen
T
T
Bonnevie
O
O
D000328:Adult; D000367:Age Factors; D000368:Aged; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005293:Ferritins / Q000097:blood*; D016481:Helicobacter Infections / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors
D006454:Hemoglobins; D007074:Immunoglobulin G; D005293:Ferritins
Helicobacter pyloris relation til jernstatus--serumferritin og haemoglobin. En seroepidemiologisk undersøgelse af 2.794 danskere.