title: Quinonic derivatives active against a virulent strain of Toxoplasma gondii. Synthesis of 2-methylfuro[2,3-g]- and [3,2-g]isoquinolinetriones.
abstract: 2-methylfuro[2,3-g]isoquinoline-4,7,9-trione (4) and 2-methylfuro[3,2-g]isoquinoline-4,6,9-trione (5) were prepared regiospecifically from 2-azadiene 9 and bromobenzofuran-4,7-diones 1 or 11. The activity of these two compounds and some other quinonic derivatives was evaluated in vitro against a virulent strain of Toxoplasma gondii. Compounds 4 and 7 were found to be as active as pyrimethamine.
authors.affiliation: Laboratoire de Chimie Organique EA 635, Université Claude Bernard, Faculté de Pharmacie, Lyon, France.
authors.forename: P
authors.initials: P
authors.lastname: Nebois
authors.forename: M E
authors.initials: ME
authors.lastname: Sarciron
authors.forename: B
authors.initials: B
authors.lastname: Bibal
authors.forename: B
authors.initials: B
authors.lastname: Bouammali
authors.forename: O
authors.initials: O
authors.lastname: Cherkaoui
authors.forename: F
authors.initials: F
authors.lastname: Pautet
authors.forename: A F
authors.initials: AF
authors.lastname: Pétavy
authors.forename: N
authors.initials: N
authors.lastname: Walchshofer
authors.forename: H
authors.initials: H
authors.lastname: Fillion
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D005663:Furans / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D009000:Monocytes / Q000187:drug effects / Q000469:parasitology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D014122:Toxoplasma / Q000187:drug effects* / Q000254:growth & development
chemical_list: D000981:Antiprotozoal Agents; D005663:Furans; D011804:Quinolines