title: [Ultrastructure study of hepatocellular carcinoma treated by diamminedichloroplatinum].
abstract: OBJECTIVE
  To study the changes of the ultrastructure of hepatocellular carcinoma (HCC) after being treated by diamminedichloroplatinum.
  
  
  METHODS
  The changes of morphological feature of HCC treated by diamminedichloroplatinum were observed with transmission electron microscope.
  
  
  RESULTS
  The cells lost its specialized cell surface elements such as microvilli and cell-cell junctions. The nucleus chromatin condensed and segregated. The cytoplasm was hollow. The ribosomes on the endoplasmic reticulum reduced or lacked. The glycogen granules reduced. The mitochondria vacuolalized or produced flocculi, and the apoptotic bodies could be found.
  
  
  CONCLUSIONS
  The changes of the ultrastructure of HCC treated by diamminedichloroplatinum correspond with the procedure of programmed cell death. Apoptosis of HCC cells can be induced by diamminedichloroplatinum.
authors.affiliation: Cancer Hospital, Guangxi Medical University, Nanning 530021, China.
authors.forename: C
authors.initials: C
authors.lastname: Wei
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Liu
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin