title: Fetal endothelial cells express vascular cell adhesion molecule in the setting of chorioamnionitis.
abstract: OBJECTIVE
  In intrauterine infection, inflammatory mediators may be released into the fetal circulation prior to fetal infection. We hypothesize that, in chorioamnionitis, inflammation alters fetal blood vessels. To test this, fetal endothelial cells were examined for vascular cell adhesion molecule (VCAM).
  
  
  METHODS
  Umbilical cords (n = 9) from placentas with chorioamnionitis were immunostained for VCAM. Controls from preterm preeclamptic pregnancies (n = 7) without histologic inflammation were selected, and matched for gestational age and method of delivery. VCAM sections were reviewed by a pathologist blinded to clinical diagnoses.
  
  
  RESULTS
  All endothelial cells from each of the nine cords from placentas with chorioamnionitis had strong VCAM staining. Two of nine samples also had acute cord vasculitis. No cord endothelial cells from preeclamptic placentas demonstrated similar VCAM staining (p < 0.01).
  
  
  CONCLUSIONS
  Histologic chorioamnionitis was associated with VCAM expression of the umbilical cord vessels. In chorioamnionitis, inflammatory mediators may have entered the fetal circulation to activate endothelial cells. Intrauterine inflammation was not restricted to the chorioamnion, but also involved the fetal circulation.
authors.affiliation: Department of Obstetrics and Gynecology, University of Utah, Salt Lake City 84108, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Craven
authors.forename: K
authors.initials: K
authors.lastname: Ward
mesh_terms: D002821:Chorioamnionitis / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology* / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D014469:Umbilical Arteries / Q000166:cytology / Q000378:metabolism; D014471:Umbilical Veins / Q000166:cytology / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1