title: Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.
abstract: We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.
authors.forename: P
authors.initials: P
authors.lastname: Dolara
authors.forename: B
authors.initials: B
authors.lastname: Corte
authors.forename: C
authors.initials: C
authors.lastname: Ghelardini
authors.forename: A M
authors.initials: AM
authors.lastname: Pugliese
authors.forename: E
authors.initials: E
authors.lastname: Cerbai
authors.forename: S
authors.initials: S
authors.lastname: Menichetti
authors.forename: A
authors.initials: A
authors.lastname: Lo Nostro
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000777:Anesthetics; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D012717:Sesquiterpenes; D013729:Terpenes; C014119:myrrh oil