Post-transcriptional regulation of lung antioxidant enzyme gene expression.
It is an honor, and indeed fitting, to have a chapter on pulmonary oxygen toxicity included in a Festschrift for Dan Gilbert, whose contributions to the free radical theory of oxygen toxicity have been a catalyst to the last half-century of investigation in this field. There is cellular damage that results in pulmonary edema and even death if the increase in reactive oxygen species produced in the lung during exposure to hyperoxia is not counterbalanced by an increase in the cell's antioxidant defense systems. In this chapter experimental evidence will substantiate the importance of post-transcriptional regulation of antioxidant enzyme gene expression in animal models of pulmonary oxygen toxicity and tolerance to hyperoxia with special emphasis given to the role of manganese superoxide dismutase (MnSOD) synthesis, specific activity, and RNA half-life and to a proposed function of a MnSOD RNA-binding protein as a positive regulator in the control of translational efficiency.
Clerch
L B
LB
Georgetown University School of Medicine, Department of Pediatrics, Washington, DC 20007, USA. clerchlb@gusun.georgetown.edu
D000222:Adaptation, Physiological; D000818:Animals; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000201:enzymology*; D008954:Models, Biological; D011485:Protein Binding; D012323:RNA Processing, Post-Transcriptional; D013482:Superoxide Dismutase / Q000235:genetics* / Q000378:metabolism
D013482:Superoxide Dismutase