Update on antiendotoxin therapies.
Endotoxin has been implicated in the processes that can lead to organ failure and death after surgery and critical illness. While there are no currently available commercial therapies directed against endotoxin, many have been tried or are in an experimental stage. In this article we outline past, present and future approaches to anti-endotoxin therapy.
Stephens
R
R
Centre for Anaesthesia, Middlesex Hospital, London.
Hamilton-Davies
C
C
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000992:Antitoxins / Q000276:immunology / Q000627:therapeutic use*; D004731:Endotoxins / Q000009:adverse effects / Q000037:antagonists & inhibitors / Q000276:immunology; D016905:Gram-Negative Bacterial Infections / Q000628:therapy; D006801:Humans; D009102:Multiple Organ Failure / Q000209:etiology; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000517:prevention & control
D000911:Antibodies, Monoclonal; D000992:Antitoxins; D004731:Endotoxins