[The hypolipidemic action of antibiotic 86/88 (enniatin B) in a hepatoblastoma G2 cell culture].
A cyclodepsipeptide antibiotic 86/88 (enniatin B) with strong hypolipidemic action was isolated from the culture liquid of the fungus INA F-86/88 identified as Fusarium lateritium Nees var. stilboides (Wr.) Bilai. In the Hep G2 cell culture the antibiotic suppressed 14C-acetate incorporation into cholesterol (IC50 1.75 microM), cholesterol ethers (IC50 1 microM), triglycerides (IC50 1.3 microM) and free fatty acids (IC50 2.2 microM). The most pronounced effect of the drugs, i.e. the suppression of the cholesterol ethers synthesis is likely due not only to the ACAT inhibition but also to the inhibition of the triglyceride synthesis and the diminishing of the free fatty acids pool in the cells.
Trenin
A S
AS
Research Institute of New Antibiotics, Russian Academy of Medical Sciences, Moscow.
Tolstykh
I V
IV
Terekhova
L P
LP
Zenkova
V A
VA
Makarova
M O
MO
Gladkikh
E G
EG
Bychkova
O P
OP
Katrujha
G S
GS
Dudnik
Iu V
IuV
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D047630:Depsipeptides; D005670:Fusarium / Q000378:metabolism; D018197:Hepatoblastoma; D006801:Humans; D000960:Hypolipidemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008113:Liver Neoplasms; D008986:Mongolia; D010455:Peptides; D012988:Soil Microbiology; D014407:Tumor Cells, Cultured / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D000960:Hypolipidemic Agents; D010455:Peptides; C100264:enniatins
Gipolipidemicheskoe deĭstvie antibiotika 86/88 (énniatina B) v kul'ture kletok gepatoblastomy G2.