Beneficial effects of prostaglandin E(1) incorporated in lipid microspheres on liver injury and regeneration after 90% partial hepatectomy in rats.
The aim of this study was to assess how the administration of prostaglandin E(1) incorporated in lipid microspheres (Lipo PGE(1)) affects liver injury and regeneration after massive hepatectomy in rats. Two hundred and eight male Wistar rats underwent 90% partial hepatectomy. Lipo PGE(1) of 1, 10 or 30 microg/kg were administered intraperitoneally at 6 h prior to and 0 and 6 h after hepatectomy. Postoperative increases in serum GOT, total bilirubin, IL-6 and plasma endotoxin levels were significantly suppressed by Lipo PGE(1). The depressed phagocytic index and arterial ketone body ratio and hepatic DNA synthesis after 90% partial hepatectomy were significantly enhanced by Lipo PGE(1), which resulted in the improvement of survival. Lipo PGE(1) might bring about a protective effect on liver injury and an enhancement of liver regeneration after massive hepatectomy.
Ando
K
K
First Department of Surgery, School of Medicine, Chiba University, Japan.
Miyazaki
M
M
Shimizu
H
H
Okuno
A
A
Nakajima
N
N
D000527:Alprostadil / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D004731:Endotoxins / Q000097:blood; D006498:Hepatectomy; D007657:Ketone Bodies / Q000378:metabolism; D008055:Lipids / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D008863:Microspheres; D010587:Phagocytosis; D051381:Rats; D017208:Rats, Wistar; D015996:Survival Rate
D004731:Endotoxins; D007657:Ketone Bodies; D008055:Lipids; D001219:Aspartate Aminotransferases; D000527:Alprostadil