The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats.
Deficit in active and inhibitory avoidance behaviour has been found in pentylenetetrazole (PTZ)-kindled rats. This supports the view that memory deficit is an integral part of epilepsy. In the present study we examined the effect of the GABA B antagonist CGP 36742 on memory deficit induced by PTZ-kindling in shuttle-box- and step-down-trained rats. The retention in CGP 36742-treated animals was significantly improved compared to the kindled controls. The mechanisms of action of CGP 36742 is considered. The favourable effect of the GABA B antagonist in cases of amnesia provoked by PTZ-kindling might be of interest in clinical practice.
Genkova-Papazova
M G
MG
Laboratory CNS Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. bl. 23, 1113, Sofia, Bulgaria. books@iph.bio.acad.bg
Petkova
B
B
Shishkova
N
N
Lazarova-Bakarova
M
M
D000647:Amnesia / Q000209:etiology / Q000517:prevention & control*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced / Q000150:complications / Q000523:psychology*; D018756:GABA Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D007696:Kindling, Neurologic; D008297:Male; D009943:Organophosphorus Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar
D018756:GABA Antagonists; D009943:Organophosphorus Compounds; C079148:(3-aminopropyl)(n-butyl)phosphinic acid; D010433:Pentylenetetrazole