Total synthesis of gigantetrocin A.
A highly efficient synthetic method for the trans-tetrahydrofuran (THF) ring building block was established and the title compound was synthesized in 19 steps from trans-1,4-dichloro-2-butene via a convergent route with a Wittig reaction as the key step.
Wang
Z M
ZM
Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
Tian
S K
SK
Shi
M
M
D000447:Aldehydes; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D004987:Ethers; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D005971:Glutamates / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D004987:Ethers; D005663:Furans; D005971:Glutamates; D007783:Lactones; C113059:gigantetracin A