Gene therapy for peripheral arterial disease.
Our understanding of the molecular biology of vascular disease is rapidly expanding, and this scientific growth has brought with it new opportunities for therapeutic intervention at the molecular and genetic levels. Although our tools for genetic manipulation in vivo and our knowledge of potential molecular targets are still crude and incomplete, the early application of these concepts to clinical problems is already underway, both in the pre-clinical and clinical arenas. The treatment of peripheral vascular disease, although greatly improved over recent decades by surgical and minimally-invasive techniques, remains limited by vascular proliferative lesions and by our inability to modulate the progression of native disease. This review explores some of the evolving concepts of therapeutic gene manipulation and their initial application in the peripheral circulation.
Mann
M J
MJ
Department of Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA. mmann@partners.org
D017130:Angioplasty / Q000009:adverse effects*; D001672:Biocompatible Materials; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000628:therapy; D015316:Genetic Therapy / Q000379:methods*; D006083:Graft Occlusion, Vascular; D006801:Humans; D006965:Hyperplasia; D018919:Neovascularization, Physiologic; D016491:Peripheral Vascular Diseases / Q000235:genetics / Q000473:pathology / Q000628:therapy*
D001672:Biocompatible Materials