[Variability of hemagglutinin from strains of influenza virus A (H3N2), isolated in Russian from 1989 to 1999].
Analysis of 154 strains isolated in Russia and CIS countries in 1989-1999 showed that influenza virus A(H3N2) caused epidemics and epidemic rises 8 times, circulating together with A(H1N1) and B viruses. Antigenic drift was revealed using polyclonal and monoclonal antibodies. Analysis of antigenic properties of the viruses in the population showed that strains isolated during the same year were usually variants of one or rarely two reference strains. A drop of isolation rate of A(H3N2) strains on chick embryos in recent years was associated with increase in these strains' sensitivity to MDCK culture. Differences in amino acid sequences of epidemic and reference strain hemagglutinins were detected. The number of positions in which the changes were detected varied from 6 to 16 in all antigenic sites: A, B, C, D. and E.
Ivanova
V T
VT
Burtseva
E I
EI
Slepushkin
A N
AN
Oskerko
T A
TA
Varmanian
R V
RV
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry / Q000276:immunology; D002460:Cell Line; D002642:Chick Embryo; D004285:Dogs; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000737:chemistry*; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology; D008969:Molecular Sequence Data; D012426:Russia / Q000453:epidemiology; D017386:Sequence Homology, Amino Acid
D000956:Antigens, Viral; D019267:Hemagglutinin Glycoproteins, Influenza Virus
Izmenchivost' gemaggliutinina shtammov virusa grippa A(H3N2), izolirovannykh v rossii s 1989 po 1999 g.