Long term changes in the visual fields of patients with temporal lobe epilepsy using vigabatrin.
OBJECTIVE
To study the long term changes in the concentric contraction of the visual field in patients with temporal lobe epilepsy on vigabatrin medication.


METHODS
Repeated Goldmann visual field examinations were compared in 27 patients with drug resistant temporal lobe epilepsy and concentric contraction of the visual field. Two groups were studied: 16 patients who had already stopped vigabatrin medication before surgery and 11 patients who continued vigabatrin medication.


RESULTS
Concentric contraction of the visual field did not change in 16 patients who stopped vigabatrin before the first examination; there was slight but significant progress in visual field loss in 11 patients who continued the use of vigabatrin.


CONCLUSIONS
Long term follow up of concentric contraction in this selected group of patients indicates that vigabatrin associated visual field loss is not reversible and that progression is possible when vigabatrin is continued.
Hardus
P
P
Department of Ophthalmology, Academic Hospital Groningen, The Netherlands.
Verduin
W M
WM
Postma
G
G
Stilma
J S
JS
Berendschot
T T
TT
van Veelen
C W
CW
D000927:Anticonvulsants / Q000627:therapeutic use*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D018709:Statistics, Nonparametric; D020888:Vigabatrin / Q000627:therapeutic use*; D058609:Visual Field Tests; D014794:Visual Fields / Q000187:drug effects*
D000927:Anticonvulsants; D020888:Vigabatrin