title: Decreasing risk of viral transfusion-transmitted diseases in Croatia.
abstract: OBJECTIVE
  To assess the risk of viral transfusion-transmitted infections in Croatia.
  
  
  METHODS
  The following parameters were analyzed: frequency of blood donations repeatedly reactive for HBsAg and anti-HCV (1993-1999); blood donations confirmed positive for HBsAg and anti-HCV (1997-1999), anti-HIV1/2, and syphilis reactivity (1993-1999); number of registered patients with hepatitis B and C; transfusion-associated hepatitis B and hepatitis C; and frequency of HBV, HCV and HIV markers in patients with congenital bleeding disorders (1993-1998).
  
  
  RESULTS
  The frequency of repeatedly reactive HBsAg and anti HCV markers and confirmed positive HBsAg, anti-HCV, and syphilis markers in donors blood decreased during the study, whereas the frequency of anti-HIV1/2 positivity did not change. The frequency of confirmed positive donors in 1999 was 0.068% for HBsAg, 0.035% for anti HCV, 0.002% for anti HIV1/2, and 0.0056% for syphilis. The number of patients with hepatitis B, hepatitis C, and transfusion-associated hepatitis B and C steadily decreased during the 1993-1998 period. The number of transfusion-associated hepatitis patients leveled off in 1997. From the beginning of the follow-up of AIDS patients in 1987, only 7 (2%) of hemophiliacs have been HIV-infected, all before 1990 and due to non-inactivated coagulation factor concentrates. There were no cases of transfusion-associated HIV2 infection in patients with congenital bleeding disorders or transfusion-associated HIV1 infection through transfusion of labile blood components.
  
  
  CONCLUSIONS
  The safety of transfusion therapy in Croatia has improved, and the present risks of viral transfusion transmitted diseases are very low.
authors.affiliation: Croatian Institute of Transfusion Medicine, Zagreb, Croatia. damir.grgicevic@hztm.tel.hr
authors.forename: D
authors.initials: D
authors.lastname: Grgicević
authors.forename: M
authors.initials: M
authors.lastname: Balija
authors.forename: D
authors.initials: D
authors.lastname: Pirc-Tiljak
authors.forename: I
authors.initials: I
authors.lastname: Mihaljević
authors.forename: I
authors.initials: I
authors.lastname: Gjenero-Margan
authors.forename: S
authors.initials: S
authors.lastname: Zupancić-Salek
authors.forename: P
authors.initials: P
authors.lastname: Macek
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission; D017523:Croatia / Q000453:epidemiology; D006509:Hepatitis B / Q000635:transmission; D006526:Hepatitis C / Q000635:transmission; D006801:Humans; D013587:Syphilis / Q000635:transmission; D065227:Transfusion Reaction; D014777:Virus Diseases / Q000453:epidemiology / Q000635:transmission*