[Prognostic factors in the treatment of advanced cervical cancer. A retrospective study].
BACKGROUND
The value of prognostic factors in patients with advanced cervix carcinoma treated by radiotherapy was assessed in a retrospective study.


METHODS
From January 1977 through December 1990, 261 patients (average age 60 years) were treated at the Radiotherapy Department of the University of Turin. Distribution by stage was: 142 T2b (54%), 8 T3a (3%), 98 T3b (38%) and 13 T4 (5%). 83% of the patients underwent radiotherapy alone; the total dose was 45-88 Gy in 91 patients (42%) with poor clinical conditions, 60-75 Gy in 121 (56%) and 75-80 Gy in 5 cases. 17% of the patients was treated by surgery combined with radiotherapy. The median follow-up was 50 months (minimum 2, maximum 177 months).


RESULTS
The 5-year NED survival and local control were 42% (52% for T2b, 33% for T3 and 15% for T4). The severe (G3-G4) complication rate was very low (1.9%).


CONCLUSIONS
In our series, the prognostic factors which significantly influenced survival in the uni-variate analysis were: advanced T stage, contemporary infiltration of parametrium and vagina, nodal status, non squamous neoplasm, younger age and the absence of brachytherapy in the radiotherapy alone protocol.
Sacco
M
M
Dipartimento di Discipline Medico-Chirurgiche, Università degli Studi, Torino.
Tessa
M
M
Rampino
M
M
Ragona
R
R
Airaldi
C
C
Nassisi
D
D
Rondi
N
N
Gatti
M
M
Garnero
G
G
Rotta
P
P
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
Fattori prognostici nel trattamento del cervicocarcinoma in stadio localmente avanzato. Studio retrospettivo.