title: Could treatment of pregnant mares prevent abortions due to equine piroplasmosis?
abstract: Treatment of pregnant mares to prevent abortions due to equine piroplasmosis is a novel idea practised empirically at some Thoroughbred studs in South Africa. This paper presents the results of an investigation to ascertain whether imidocarb dipropionate crosses the equine placenta. Three pregnant mares were injected intramuscularly with imidocarb and their foetuses were mechanically aborted at varying time intervals thereafter. Imidocarb was found in foetal blood at a level similar to that in the dam's blood, suggesting that imidocarb administered to the dam would be available for anti-parasitic activity in the foetal circulation. Uncertainty concerning the time of treatment to achieve the desired effect currently makes this a questionable exercise.
authors.affiliation: Department of Biology, Medical University of Southern Africa, Medunsa, South Africa.
authors.forename: B D
authors.initials: BD
authors.lastname: Lewis
authors.forename: B L
authors.initials: BL
authors.lastname: Penzhorn
authors.forename: D H
authors.initials: DH
authors.lastname: Volkmann
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control*; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001404:Babesiosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy* / Q000517:prevention & control; D006736:Horses; D007095:Imidocarb / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007273:Injections, Intramuscular / Q000662:veterinary; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000981:Antiprotozoal Agents; D007095:Imidocarb; C031719:imidocarb dipropionate