Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury.
1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down-regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor kappa B and c-jun), Bcl-2 family members and caspases.
Coulson
E J
EJ
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Reid
K
K
Murray
S S
SS
Cheema
S S
SS
Bartlett
P F
PF
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D016923:Cell Death / Q000502:physiology; D015536:Down-Regulation / Q000235:genetics; D006801:Humans; D009474:Neurons / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology*; D014157:Transcription Factors; D014947:Wounds and Injuries / Q000473:pathology*
D048868:Adaptor Proteins, Signal Transducing; C504649:PSIP1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors