[The mechanisms of the curative action of systemic enzyme therapy].
Employment of the authors' highly sensitive biochemical method allowed the fact of resorption of proteolytic enzymes after their peroral ingestion to be confirmed, with a question having been raised as to further fate of proteinases and mechanisms of curative action of combined enzyme preparations. The analysis of relevant data from published literature and the results of the author's own studies permitted identifying the most important moments of realization of the systemic enzyme therapy effects, which are as follows: 1) activation of receptors on the surface of enterocytes; 2) formation of activated alpha 2-macroglobulin (alpha 2-M) under the action of proteinases from the intestines, and realization of catalytic activity of those enzymes involved in this restrictor of proteinases; 3) modulation of cell activity by complexes alpha 2-M-proteinase; 4) activation of the system of mononuclear phagocytes; 5) influence on the balance of bodily endogenous proteolytic systems.
Veremeenko
K N
KN
Dosenko
V E
VE
Kizim
A I
AI
Terzov
A I
AI
D004338:Drug Combinations; D004347:Drug Interactions; D010450:Endopeptidases / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006868:Hydrolysis; D010179:Pancreas / Q000201:enzymology; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism
D004338:Drug Combinations; D011956:Receptors, Cell Surface; D010450:Endopeptidases
O mekhanizmakh lechebnogo deĭstviia sistemnoĭ énzimoterapii.