Role of protein kinase C in cerebral vasospasm: past and future.
The possible role of protein kinase C in chronic cerebral vasospasm after subarachnoid hemorrhage has been suggested for a decade. Experimental results in vitro or in animal models support that protein kinase C is involved in the prolonged contraction of cerebral arteries similar to cerebral vasospasm. Activation of protein kinase C may interact with other signaling pathways such as myosin-light chain kinase, nitric oxide, intracellular Ca2+, and more recently protein tyrosine kinase and its substrates such as mitogen-activated protein kinase. A protein kinase C network may be activated during cerebral vasospasm.
Zhang
J H
JH
Department of Neurosurgery, University of Mississippi Medical Center, Jackson 39216, USA. jzhang@neurosurgery.umsmed.edu
D000818:Animals; D002536:Cerebral Arteries / Q000201:enzymology; D006801:Humans; D011493:Protein Kinase C / Q000378:metabolism*; D013345:Subarachnoid Hemorrhage / Q000201:enzymology; D020301:Vasospasm, Intracranial / Q000201:enzymology*
D011493:Protein Kinase C