Subhypnotic dose of propofol for the prevention of nausea and vomiting during spinal anaesthesia for caesarean section.
This study was undertaken to evaluate the efficacy of subhypnotic doses of propofol for the prevention of nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia. In a randomized, double-blinded, placebo-controlled manner, 60 patients received intravenously lignocaine 0.1 mg/kg (for injection pain relief) followed by either placebo (Intralipid) or propofol at subhypnotic dose (1.0 mg/kg/h) (n = 30 of each) immediately after clamping of the fetal umbilical cord. Emetic episodes and safety assessments were performed during spinal anesthesia for caesarean section. The incidence of patients who were emesis-free in the intraoperative, post-delivery period was 37% with placebo and 77% with propofol, respectively (P = 0.001). No clinically important adverse events were observed in either group. In conclusion, a subhypnotic dose (1.0 mg/kg/h) of propofol is effective for preventing nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia.
Numazaki
M
M
Department of Anaesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.
Fujii
Y
Y
D000328:Adult; D000704:Analysis of Variance; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D000779:Anesthetics, Local / Q000008:administration & dosage; D000932:Antiemetics / Q000627:therapeutic use; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007430:Intraoperative Care; D008012:Lidocaine / Q000008:administration & dosage; D008787:Metoclopramide / Q000627:therapeutic use; D010919:Placebos; D020250:Postoperative Nausea and Vomiting / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects; D012449:Safety
D018686:Anesthetics, Intravenous; D000779:Anesthetics, Local; D000932:Antiemetics; D010919:Placebos; D008012:Lidocaine; D008787:Metoclopramide; D015742:Propofol