Endothelial cell autoantibodies are a marker of disease susceptibility in inflammatory bowel disease but apparently not linked to persistent measles virus infection.
Intestinal vasculitis caused by persistent measles virus infection of intestinal endothelial cells was described in Crohn's disease. Furthermore, endothelial cell autoantibodies have been demonstrated in inflammatory bowel disease (IBD). Autoantibodies against intestinal endothelial cells were visualized by indirect immunofluorescence in patients with IBD, in their healthy first-degree relatives, in patients with infectious enterocolitis, and in healthy, unrelated controls. In intestinal tissue specimens of 22 antibody-positive IBD patients a search for the measles virus genome was performed. Endothelial cell autoantibodies were significantly more frequent in patients with IBD, in both groups of first-degree relatives, and in patients with infectious enterocolitis than in the healthy controls (P = 0.0002 or less). The measles virus genome was found in none of the intestinal biopsies. Endothelial cell autoantibodies are not a genetic but rather an epigenetic (infectious) marker of disease susceptibility. The expression of these autoantibodies is unlikely to be triggered by a persistent measles virus infection.
Folwaczny
C
C
Medizinische Klinik, Klinikum Innenstadt, Ludwig-Maximilians Universität, Munich, Germany.
Loeschke
K
K
Schnettler
D
D
Jäger
G
G
Wiebecke
B
B
Hoelscher
M
M
Sauer
T
T
König
A
A
Endres
S P
SP
Fricke
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004198:Disease Susceptibility / Q000276:immunology; D004730:Endothelium, Vascular / Q000166:cytology* / Q000276:immunology*; D005192:Family Health; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D008297:Male; D008457:Measles / Q000097:blood*; D008875:Middle Aged
D001323:Autoantibodies; D015415:Biomarkers