The effect of oral sodium taurocholate on endotoxemia and intestinal anastomotic wound healing in rats with obstructive jaundice.
The effect of sodium taurocholate (ST) on endotoxemia and intestinal anastomotic wound healing in obstructive jaundice was evaluated in a rat model. A total of 108 Wistar rats were divided into three main groups. Thus, 36 animals were given ileal anastomosis (IA) alone (IA group), 36 were given IA with bile duct ligation (BDL) (IA + BDL group), and 36 were given IA with BDL and oral sodium taurocholate (ST) (IA + BDL + ST group). These three main groups were then divided into three equal subgroups, A, B, and C, which were killed on postoperative days (POD) 3, 5, and 9, respectively. In the IA + BDL + ST group, ST was administrated perioperatively and ceased from POD 5 onwards. The anastomotic hydroxyproline level and bursting pressure were significantly lower in the IA + BDL animals compared with the others on POD 3, 5, and 9 (P < 0.008). Endotoxemia was prominent in the IA + BDL group from POD 3 (P = 0.011). After ST was stopped, 42% of the AI + BDL + ST animals developed endotoxemia by POD 9 (P = 0.008). Anastomotic wound healing was better in the IA + BDL + ST group (P < 0.01). These findings suggest that endotoxemia and its adverse effects on wound healing in obstructive jaundice can be prevented by the oral administration of ST.
Sayan
M
M
Department of Surgery, University of Istanbul, Cerrahpasa Medical School, Aksaray, Istanbul, Turkey.
Alponat
A
A
Yavuz
N
N
Altinkaya
E
E
Göksel
S
S
Sariyar
M
M
D000714:Anastomosis, Surgical; D000818:Animals; D002779:Cholestasis / Q000503:physiopathology*; D019446:Endotoxemia / Q000503:physiopathology*; D005260:Female; D006909:Hydroxyproline / Q000378:metabolism; D007082:Ileum / Q000601:surgery; D007422:Intestines / Q000601:surgery*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013656:Taurocholic Acid / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D013656:Taurocholic Acid; D006909:Hydroxyproline