title: Brain and ventricle instability during psychotic episodes of the schizophrenias.
abstract: Recent reports from serial brain scans suggest that the rate of ventricular expansion and/or brain atrophy may be accelerated in at least some schizophrenics. The authors assessed the effect of state changes upon such findings.Within-subject 3D MRIs were assessed for ventricular and brain volumes during periods of [partial] remission and of exacerbation of psychosis. Additional scans at comparable within-subject SAPS were used to assess rates of change in volumes that were independent of SAPS changes. Correlations of changes of ventricle and brain volumes vs. change of SAPS cores between scans revealed that ventricle volumes decreased during a period of psychotic exacerbation and increased at a time of [partial] remission (r(p)=-0.666; P<0.0005); conversely, brain volumes increased during psychotic exacerbation and decreased at [partial] remission (r(p)=+0.448; P=0.032). Scans at comparable SAPS scores suggested that the majority of patients had rates of ventricular expansion comparable to controls (0.9+/-0.6 cc/year), though two patients appeared to have rates of ventricular increase of 4.5+/-2. 1 cc/year (Lilliefores P=0.036; K-means clustering F=17.75). Exacerbation of psychosis in schizophrenia is accompanied by evidence of brain swelling, especially of periventricular brain, with encroachment of brain substance upon ventricular volumes. Controlled for state changes, the majority of schizophrenics show rates of ventricular expansion or brain atrophy indistinguishable from controls.
authors.affiliation: University of Louisville School of Medicine, Department of Psychiatry and Behavioral Sciences, Louisville, KY 40222, USA. garverdl@msn.com
authors.forename: D L
authors.initials: DL
authors.lastname: Garver
authors.forename: T R
authors.initials: TR
authors.lastname: Nair
authors.forename: J D
authors.initials: JD
authors.lastname: Christensen
authors.forename: J A
authors.initials: JA
authors.lastname: Holcomb
authors.forename: S J
authors.initials: SJ
authors.lastname: Kingsbury
mesh_terms: D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000175:diagnosis; D002552:Cerebral Ventricles / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology