Leptin facilitates histamine release from the hypothalamus in rats.
We studied the effect of leptin on the release of histamine from the anterior hypothalamus using an in vivo microdialysis in anesthetized rats. Histamine release was significantly increased by leptin administration (1.3 mg/kg, i.p.) and kept at a high level for 4 h after the injection. The same dose of leptin significantly reduced food intake in another group of rats. This finding suggests that leptin activates the histaminergic system in the hypothalamus, which may contribute the expression of leptin-induced anorectic effect.
Morimoto
T
T
Department of Medical Physics, School of Allied Health Sciences, Faculty of Medicine, Osaka University, 565-0871, Osaka, Japan.
Yamamoto
Y
Y
Yamatodani
A
A
D000818:Animals; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000378:metabolism*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D017551:Microdialysis; D051381:Rats; D017208:Rats, Wistar
D020738:Leptin; D006632:Histamine