title: An investigation of the effect of 2 sedation regimens on patient mood state following upper extremity surgery using local anesthesia.
abstract: Sedation techniques for patients undergoing minor outpatient surgery frequently include a variety of intravenous agents. The present study was designed to look for differential effects of 2 different sedation regimens on perioperative mood states. Twenty-two patients undergoing upper extremity surgery using local anesthesia were randomized to receive either propofol or midazolam intravenously for intraoperative sedation. Subjects were asked to complete a Profile of Mood States survey before and after surgery. The results of this survey were examined for differences in mood between the 2 groups that may be attributable to differences in drug effect. No significant differences were identified between propofol or midazolam regarding their effect on patient mood. Patients in both groups experienced a reduction in perioperative anxiety.
authors.affiliation: Mayo Clinic, Rochester, Minn., USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Baker
authors.forename: C A
authors.initials: CA
authors.lastname: Benz
authors.forename: N A
authors.initials: NA
authors.lastname: Dalton
authors.forename: J J
authors.initials: JJ
authors.lastname: Smith
authors.forename: A N
authors.initials: AN
authors.lastname: Stillmunkes
authors.forename: B A
authors.initials: BA
authors.lastname: Elliott
authors.forename: E S
authors.initials: ES
authors.lastname: Thompson
mesh_terms: D000759:Adjuvants, Anesthesia / Q000009:adverse effects*; D000328:Adult; D000339:Affect / Q000187:drug effects*; D000772:Anesthesia, Local / Q000009:adverse effects* / Q000379:methods* / Q000451:nursing; D001132:Arm / Q000601:surgery*; D016292:Procedural Sedation / Q000009:adverse effects* / Q000379:methods* / Q000451:nursing; D005260:Female; D006801:Humans; D008297:Male; D008874:Midazolam / Q000009:adverse effects*; D015742:Propofol / Q000009:adverse effects*
chemical_list: D000759:Adjuvants, Anesthesia; D008874:Midazolam; D015742:Propofol