[Neonatal hyperthyroidism in a premature infant born to a mother with Grave's disease].
BACKGROUND
Neonatal thyrotoxicosis is most commonly due to transplacental transfer of maternal thyroid-stimulating hormone receptor antibodies (TRAb). Bioassay of thyrotropin receptor antibodies may help to determine the risk for neonatal hyperthyroidism.


METHODS
Thyrotoxicosis developed in a premature infant born to a mother with Graves' disease, with a low level of TRAb by bioassay. The infant was treated with carbimazole for two months, until TRAb had disappeared.


CONCLUSIONS
Bioassay TRAb is not always reliable for predicting the development of neonatal hyperthyroidism in infants born to mothers with Graves' disease. Thyroid function should be measured in all these neonates.
Nicaise
C
C
Service de pédiatrie et néonatologie, CHU Nord, chemin des Bourrelys, Marseille, France.
Gire
C
C
Brémond
V
V
Minodier
P
P
Soula
F
F
d'Ercole
C
C
Palix
C
C
D000328:Adult; D001681:Biological Assay; D005260:Female; D006111:Graves Disease; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D011248:Pregnancy Complications; D011988:Receptors, Thyroid Hormone / Q000032:analysis* / Q000276:immunology; D011989:Receptors, Thyrotropin / Q000032:analysis* / Q000276:immunology; D013971:Thyrotoxicosis / Q000175:diagnosis / Q000209:etiology*
D011988:Receptors, Thyroid Hormone; D011989:Receptors, Thyrotropin
Hyperthyroïdie néonatale chez un prématuré né de mère atteinte d'une maladie de Basedow.