[Examination and evaluation of sIL-6R, sgp130 in serum in patients with chronic hepatopathy].
OBJECTIVE
To observe the variation of soluble interleukin-6 receptor (sIL-6R) and soluble interleukin-6 receptor beta strands (sgp130) in patients with chronic hepatopath.


METHODS
We examined sIL-6R and sgp130 level in 40 patients with chronic hepatitis (CH), 15 with cirrhosis following hepatitis, and 35 normal controls (NC) in serum by enzyme linked immunosorbent assay (ELISA) method.


RESULTS
The content of sIL-6R and sgp130 in serum was higher in CH group (224.27 mug/L and 489.35 mug/L, respectively) than NC group (174.81 mug/L and 273.64 mug/L respectively). The two parameters above in patients with hepatocirrhosis were higher than those in patients with chronic hepatitis, and the content in order of quantity was severe>moderate>slight. There was significant difference among the three groups (P<0.05, P<0.01), and positive correlation between sIL-6R and sgp130 level (r=0.481, P<0.05), between sIL-6R, sgp130 level and total bilirubin level (r=0.417, r=0. 428, P<0.01). While sIL-6R, sgp130 was no significant correlation to ALT (r=0.173, r=0.182, P>0.05).


CONCLUSIONS
sIL-6R and sgp130 in serum are associated with the development of chronic hepatopath, and therefore can guide the assessment of prognosis.
Shang
J
J
Department of Digestive Disease, Peoples' Hospital of Henan Province, Zhengzhou 450003, China.
Xu
Y
Y
Zhang
H
H
D000328:Adult; D005260:Female; D006521:Hepatitis, Chronic / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D019947:Receptors, Interleukin-6 / Q000097:blood*
D019947:Receptors, Interleukin-6