title: Stimulation of the small intestine by nutrients in relation to phase of the migrating motor complex.
abstract: BACKGROUND
  The relationship between the preceding phase of the migrating motor complex (MMC) and postprandial motility in the small intestine was studied.
  
  
  METHODS
  In eight healthy subjects small-bowel manometry was performed, and a 55-ml caloric liquid bolus (280 kJ) containing paracetamol and 14C-D-xylose was instilled into the duodenum during phase I and late phase II of the intestinal MMC, respectively, in randomized order. Blood samples were drawn at regular intervals and analysed for insulin, gastrin, glucose, paracetamol, and 14C-D-xylose.
  
  
  RESULTS
  After bolus administration during late phase II a phase-III-like activity succeeded by quiescence occurred in the duodenum in seven of eight subjects, whereas administration during phase I initiated irregular contractions in seven of eight subjects (P < 0.05). The caloric bolus induced a significant increase in serum insulin and gastrin. Areas under the curves for serum insulin, gastrin, glucose, paracetamol, and 14C-D-xylose were not modulated by the preceding phase of the MMC.
  
  
  CONCLUSIONS
  The present study shows that a nutrient bolus instilled into the intestinal lumen induces MMC-like activity when administered during late phase II. These findings provide further evidence of interference between MMC and postprandial motility.
authors.affiliation: Dept. of Medicine, Ullevål University Hospital, Oslo, Norway.
authors.forename: A W
authors.initials: AW
authors.lastname: Medhus
authors.forename: O
authors.initials: O
authors.lastname: Sandstad
authors.forename: J
authors.initials: J
authors.lastname: Bredesen
authors.forename: E
authors.initials: E
authors.lastname: Husebye
mesh_terms: D000082:Acetaminophen / Q000097:blood; D000328:Adult; D001786:Blood Glucose; D005766:Gastrointestinal Contents; D006801:Humans; D007421:Intestine, Small / Q000502:physiology*; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology; D013997:Time Factors; D014994:Xylose / Q000097:blood
chemical_list: D001786:Blood Glucose; D000082:Acetaminophen; D014994:Xylose