[The current concepts of the pathogenesis of Mönckeberg-type arteriosclerosis].
On the basis of experimental researches the circuit of pathogenesis of Mönckeberg's arteriosclerosis--one of the most widespread types of arteriosclerosis is offered. The most important mechanisms realized during development of this pathological process, following: 1) actions of the injuring factor cause necrobiotic change of vascular wall cells; 2) activation of proteolytic enzymes, disturbance of balance between proteinases and their natural inhibitors results in destruction of extracellular matrix fibers and excessive stimulation by products limited proteolysis of vascular wall cell; 3) infringements of intracellular ion homeostasis at the expense of the mentioned below factors exhaust energy systems (last in case of metabolic poison action can be primary are damaged); 4) infringements in system of blood, in particular, in calcium homeostasis, blood coagulation, lipid spectrum promote additional damage of vascular wall cells; 5) dystrophic and metastatic calcification of media; 6) development "unspecific mesenchymal reaction", including fibrosis and sclerosis, in damage zone of vascular wall.
Byts'
Iu V
IuV
A. A. Bogomoletz National Medical University, Ministry of Public Health of Ukraine, Kiev.
Holdobina
O V
OV
Dosenko
V Ie
VIe
Dudko
M O
MO
Larionova
N A
NA
D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology / Q000209:etiology* / Q000473:pathology; D002114:Calcinosis / Q000201:enzymology / Q000473:pathology; D004195:Disease Models, Animal; D009336:Necrosis; D010447:Peptide Hydrolases / Q000378:metabolism; D012598:Sclerosis; D017540:Tunica Media / Q000201:enzymology / Q000473:pathology
D010447:Peptide Hydrolases
Suchasni uiavlennia pro patohenez arteriosklerozu menkeberhivs'koho typu.