Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules.
An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine hit was conducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency.
Wang
W
W
BioChem Pharma Inc., Laval, Québec, Canada. wangwu@biochempharma.com
Préville
P
P
Morin
N
N
Mounir
S
S
Cai
W
W
Siddiqui
M A
MA
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D010619:Phenazines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D010619:Phenazines