The synthesis and in vitro cytotoxic studies of novel oxa-spermidine derivatives and homologues.
A series of oxa-spermidine derivatives and homologues were prepared and their anticancer properties were evaluated. All these compounds showed an average GI50 value in the range of 3.9-28.9 microM. SAR studies showed that the presence of a sulphonamido functionality and the length of the alkyl chain are important factors for an enhanced activity.
Kuksa
V A
VA
Department of Ophthalmology, School of Medicine, University of Washington, Seattle 98195-6485, USA.
Pavlov
V A
VA
Lin
P K
PK
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013095:Spermidine / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D013095:Spermidine