[Alterations of arterial vessel wall properties in hyperparathyroidism].
Alterations of arterial vessel wall function are associated with increased cardiovascular morbidity and can be measured by noninvasive ultrasound techniques. There is increasing evidence that hyperparathyroidism contributes not only to structural changes of the cardiovascular system but to disturbances in functional arterial vessel wall properties. It has been shown that elevated concentrations of parathyroid hormone are associated with decreased arterial distensibility and increased intima-media thickness in patients with renal insufficiency. A permissive role of parathyroid hormone in the pathogenesis of uremic vessel wall changes has been discussed. The endothelium is a newly recognized target organ of parathyroid hormone. In patients with primary hyperparathyroidism endothelial dysfunction has been demonstrated, that seems to be reversible after parathyroidectomy. Effects on arterial vessel wall function may contribute to increased blood pressure observed in hyperparathyroidism. The complex cardiovascular effects of parathyroid hormone and changes in vascular tone, arterial distensibility and endothelial function in hyperparathyroidism are discussed.
Kosch
M
M
Medizinische Poliklinik, Westfälischen Wilhelms-Universität Münster. koschm@uni-muenster.de
Hausberg
M
M
Kisters
K
K
Barenbrock
M
M
D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications* / Q000503:physiopathology; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000009:adverse effects*; D017539:Tunica Intima / Q000503:physiopathology; D017540:Tunica Media / Q000503:physiopathology
D010281:Parathyroid Hormone
Funktionelle Gefässwandveränderungen bei Hyperparathyreoidismus.