Mismatch negativity and N100 monitoring: potential clinical value and methodological advances.
Continuous long-term recording of brainstem (BAEPs), middle-latency (MLAEPs) and long-latency auditory evoked potentials, including the mismatch negativity (MMN), brings additional information on the immediate functional state and the outcome of patients in coma or recovering after surgery, in relation with clinical observations and therapeutics. A recently designed monitoring system is introduced, aimed at the continuous recording of late auditory potentials (N100 and MMN) as well as BAEPs and MLAEPs. Specific methodological aspects are emphasized. Long-term monitoring data from one patient recorded in the recovery room after surgery are displayed, allowing an illustration of the techniques used and of the problems raised.
Morlet
D
D
INSERM U280, Mental Process and Brain Activation, Neurological Hospital, Lyon, France. morlet@lyon151.inserm.fr
Bouchet
P
P
Fischer
C
C
D000328:Adult; D001139:Arnold-Chiari Malformation / Q000601:surgery; D001303:Auditory Cortex / Q000503:physiopathology; D001306:Auditory Pathways / Q000503:physiopathology; D001933:Brain Stem / Q000503:physiopathology; D003128:Coma / Q000503:physiopathology*; D003265:Contingent Negative Variation / Q000502:physiology*; D003422:Critical Care; D004569:Electroencephalography / Q000295:instrumentation*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D011183:Postoperative Complications / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*