Population pharmacokinetics/pharmacodynamics modeling: parametric and nonparametric methods.
As clinicians acquire experience with the clinical and pharmacokinetic behavior of a drug, it is usually optimal to record this experience in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The role of population modeling is thus to describe and record clinical experience with the behavior of a drug in a certain group or population of patients or subjects.
Jelliffe
R
R
Laboratory of Applied Pharmacokinetics, USC School of Medicine, Los Angeles, USA.
Schumitzky
A
A
Van Guilder
M
M
D000465:Algorithms; D000583:Amikacin / Q000493:pharmacokinetics; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics; D001499:Bayes Theorem; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D010599:Pharmacokinetics; D018709:Statistics, Nonparametric; D014640:Vancomycin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D000583:Amikacin