Influence of short-term repeated fasting on the longevity of female (NZB x NZW)F1 mice.
Caloric restriction in rodents is well known to retard the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many age-associated diseases. However, little is known about the influence of short-term repeated fasting on longevity. In this study, female (NZB x NZW)F1 mice were used to test the physiological effect of short-term repeated fasting (4 consecutive days, every 2 weeks). The results showed that fasting mice survived significantly longer than the full-fed mice, in spite of the fasting group having a heavier body weight than the control group. Mean survival times for fasting and control mice were 64.0+/-15.3 and 47.9+/-9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice.
Sogawa
H
H
Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan. sogawa@cephal.med.kyushu-u.ac.jp
Kubo
C
C
D000818:Animals; D005215:Fasting / Q000502:physiology*; D005260:Female; D007694:Killer Cells, Natural / Q000502:physiology; D008136:Longevity / Q000502:physiology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008814:Mice, Inbred NZB; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000494:pharmacology; D009929:Organ Size / Q000502:physiology; D011507:Proteinuria / Q000652:urine; D012016:Reference Values; D016019:Survival Analysis; D013997:Time Factors; D015430:Weight Gain
D008934:Mitogens