title: [Sleep apnea syndrome in acromegaly. Treatment and development-- retrospective analysis].
abstract: In total 56 subjects with acromegaly (37 men and 19 females) were examined in attempt to find sleep apnoea syndrome (SAS). The examination consisted of clinical examination and of all-night monitoring MESAM4 or polyMESAM. The diagnosis of SAS was established in 76.4% of subjects: 31 men and 11 females, average age 51.8 (SD +/- 9.6) years. The average ODI (oxygen desaturation index--number of oxygen saturation drops per 1 hour of sleep) of SAS patients was 29.2 (+/- 20.7). The therapy of SAS was recommended to 27 patients: sleeping position on the side (3 patients), reduction of the weight (8 patients), change of hypnotic drug (1 patient) and CPAP--continuous positive airway pressure (24 patients). CPAP titration was performed in 18 patients (in one subject the titration was repeated 4 years later). CPAP was titrated within all-night polysomnography in 10 subjects and in 9 subjects using self adjusting CPAP. Primary acceptance of CPAP was 94.4%. The average CPAP pressure was 7.8 (+/- 2.1) mbar. The theoretical duration of CPAP use was 546.6 (+/- 533.7) days. Long term compliance was considered as sufficient (weekly 25 hours or more) in 66.7% of patients. Ten patients underwent important acromegaly therapy or its change during the follow up and the improvement or the disappearance of SAS symptoms occurred in 6 of them.
authors.affiliation: Neurologická klinika a, 1. lékarské fakulty Univerzity Karlovy, Praha, Czech Republic.
authors.forename: K
authors.initials: K
authors.lastname: Sonka
authors.forename: V
authors.initials: V
authors.lastname: Weiss
authors.forename: S
authors.initials: S
authors.lastname: Dostálová
authors.forename: M
authors.initials: M
authors.lastname: Pretl
authors.forename: J
authors.initials: J
authors.lastname: Marek
authors.forename: D
authors.initials: D
authors.lastname: Horínek
authors.forename: E
authors.initials: E
authors.lastname: Faltýnová
authors.forename: P
authors.initials: P
authors.lastname: Rambousek
authors.forename: P
authors.initials: P
authors.lastname: Busek
authors.forename: V
authors.initials: V
authors.lastname: Hána
mesh_terms: D000172:Acromegaly / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D012189:Retrospective Studies; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000175:diagnosis / Q000628:therapy
vernacular_title: Spánkový apnoický syndrom (SAS) u akromegalie. Lécení a vývoj--retrospektivní analýza.