title: Inhibition of neuraminidase with neuraminic acid C-glycosides.
abstract: Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15-30 microM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.
authors.affiliation: Department of Chemistry, Medicinal and Natural Products Chemistry and Chemical and Biochemical Engineering, The University of Iowa, Iowa City 52242, USA.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Wolff
authors.forename: T
authors.initials: T
authors.lastname: Polat
authors.forename: Y
authors.initials: Y
authors.lastname: Du
authors.forename: R J
authors.initials: RJ
authors.lastname: Linhardt
mesh_terms: D002021:Buffers; D003016:Clostridium perfringens / Q000187:drug effects / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006027:Glycosides / Q000138:chemical synthesis / Q000494:pharmacology; D009438:Neuraminic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
chemical_list: D002021:Buffers; D004791:Enzyme Inhibitors; D006027:Glycosides; D009438:Neuraminic Acids; D009439:Neuraminidase