title: Sipandinolide: a butenolide including a novel type of carbon skeleton from Siparuna andina.
abstract: From a lipophilic extract of leaves of Siparuna andina (Monimiaceae), which exhibited antiplasmodial activity in vitro, two new compounds have been isolated: sipandinolide (1), a compound with a novel type of carbon skeleton and (-)-cis-3-acetoxy-4',5,7-trihydroxyflavanone (2). Their structures were established by spectroscopic methods; 2 showed moderate antiplasmodial activity whereas 1 was inactive.
authors.forename: K
authors.initials: K
authors.lastname: Jenett-Siems
authors.forename: K
authors.initials: K
authors.lastname: Siems
authors.forename: J
authors.initials: J
authors.lastname: Jakupovic
authors.forename: P N
authors.initials: PN
authors.lastname: Solis
authors.forename: M P
authors.initials: MP
authors.lastname: Gupta
authors.forename: F P
authors.initials: FP
authors.lastname: Mockenhaupt
authors.forename: U
authors.initials: U
authors.lastname: Bienzle
authors.forename: E
authors.initials: E
authors.lastname: Eich
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D007783:Lactones; C412408:sipandinolide; D002244:Carbon