title: Reversible alterations in brain metabolites during therapy for disseminated nocardiosis using proton magnetic resonance spectroscopy.
abstract: We report reversible abnormalities in magnetic resonance spectra acquired from a patient with AIDS undergoing antibiotic and corticosteroid therapy for disseminated nocardiosis, a rare opportunistic infection of immunosuppressed patients which can cause cerebral abscess formation. There was no clinical, CT or MRI evidence of HIV-1 encephalitis. MR spectra were acquired before and after treatment using a two-dimensional chemical shift imaging technique (TR 1500ms, TE 130ms). Prior to treatment, a rise in the choline to creatine ratio and a reduction in the N-acetylaspartate to creatine ratio were observed in MR spectra localized to areas of the left anteromedial centrum semiovale that appeared normal on MR imaging. After 16 weeks, the patient had recovered with complete resolution of the cerebral abscesses on MRI. The MR spectral abnormalities also returned to normal. Two months later, the patient had a relapse with focal neurological signs and further abscesses were demonstrated on MRI of the brain. The patient subsequently died and histopathological and microbiological findings at autopsy confirmed the clinical picture of a recurrence of cerebral nocardiosis with no evidence of HIV-1 encephalitis. This case illustrates reversible MR-measurable metabolite changes in the brain of an HIV-seropositive patient without HIV-1 encephalitis who underwent treatment for cerebral nocardiosis.
authors.affiliation: The Robert Steiner MRI Unit, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom. cmarcus@chu-reims.fr
authors.forename: C D
authors.initials: CD
authors.lastname: Marcus
authors.forename: S D
authors.initials: SD
authors.lastname: Taylor-Robinson
authors.forename: I J
authors.initials: IJ
authors.lastname: Cox
authors.forename: J
authors.initials: J
authors.lastname: Sargentoni
authors.forename: S
authors.initials: S
authors.lastname: Shaunak
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D001922:Brain Abscess / Q000378:metabolism / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009617:Nocardia Infections / Q000378:metabolism* / Q000473:pathology*; D009616:Nocardia asteroides; D011522:Protons; D016896:Treatment Outcome
chemical_list: D011522:Protons