title: Identification of T-helper cell epitopes in the hypervariable region of the nucleocapsid (N) protein of rinderpest virus (RPV) in cattle.
abstract: The proliferative responses to synthetic peptides by lymphocytes derived from rinderpest virus (RPV)-infected cattle, the natural host for RPV, were assayed by determining [3H]thymidine incorporation into the DNA. In eight out of twelve cattle tested, significant responses were detected to peptides representing amino acids 452-501 in the C-terminal hypervariable region of the virus nucleocapsid (N) protein. It appears that helper T-cell epitope(s) for cattle which can be broadly recognized within an MHC diverse population, exists in this region of the protein.
authors.affiliation: Institute for Animal Health, Pirbright Laboratory, Ash Road, Surrey, GU24 0NF, Woking, UK.
authors.forename: K
authors.initials: K
authors.lastname: Ohishi
authors.forename: H
authors.initials: H
authors.lastname: Kamata
authors.forename: K
authors.initials: K
authors.lastname: Yamanouchi
authors.forename: T
authors.initials: T
authors.lastname: Barrett
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D018984:Epitopes, T-Lymphocyte; D007114:Immunization; D008969:Molecular Sequence Data; D019251:Nucleocapsid / Q000276:immunology*; D010446:Peptide Fragments / Q000276:immunology*; D012302:Rinderpest virus / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism
chemical_list: D018984:Epitopes, T-Lymphocyte; D010446:Peptide Fragments; D013936:Thymidine