Antibody responses to sheep red blood cell and Brucella abortus antigens in a turkey line selected for increased body weight and its randombred control.
Turkeys from a randombred control line (RBC2) and its subline (F) selected for increased 16-wk BW were tested for primary and secondary antibody responses to SRBC antigen and Brucella abortus antigen (BA). Previous studies have shown that the F line was more susceptible to Pasteurella multocida and Newcastle disease virus than was the RBC2 line. Individuals from the RBC2 and F lines were intravenously injected with 1 mL 5% SRBC antigen or 0.1 mL undiluted BA at 4 and 6 wk of age; blood samples were collected at 0, 4, 7, and 10 d post-immunization. Total, IgG, and IgM titers were measured by agglutination assays. Compared with the RBC2 line, the F line had generally higher total anti-SRBC titers; the differences were significant at 14 d postprimary immunization (PPI) (females); at 10 d postsecondary immunization (PSI) (males); and 4, 7, and 10 d PSI (females) (P < or = 0.05). The F line also had higher IgM titers at 14 d PPI (females) and at 10 d PSI (males) (P < or = 0.05). For IgG titers, a line difference was evident in females at 4 and 10 d PSI (P < or = 0.05); the F line had higher titers than did the RBC2 line. For the antibody response to BA in males, the F line had lower total and IgM titers at 10 d PPI (P < 0.05) than did the RBC2 line. No significant line differences in response to the BA were found in total and IgM titers in female turkeys or in IgG titers in both sexes at any time. These results suggest that selection for fast growth rate of turkeys might have resulted in changes in humoral immunity to the SRBC antigen and BA.
Li
Z
Z
Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA.
Nestor
K E
KE
Saif
Y M
YM
Anderson
J W
JW
D000818:Animals; D000906:Antibodies / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology*; D001835:Body Weight / Q000235:genetics; D001947:Breeding; D002003:Brucella abortus / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007700:Kinetics; D008297:Male; D012641:Selection, Genetic; D012756:Sheep; D013045:Species Specificity; D014422:Turkeys / Q000235:genetics* / Q000276:immunology*
D000906:Antibodies; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M