[Dysregulation of the genes controlling apoptosis in cancer development].
Apoptosis is a cellular self-destruction mechanism involved in a variety of biological events. Cancer is a disorder of autonomous cell proliferation and accumulation, which is associated with the failure to undergo apoptosis in response to appropriate stimuli. Inhibition of apoptosis may be a prerequisite or acquired biological feature of various cancer cells. Resistance to apoptosis is achieved either by an increase in apoptosis resistance or decrease in apoptosis sensitivity. Some of the hereditary cancer syndrome patients have mutations in the genes to induce apoptosis, eventually leading to inhibition of apoptosis and cancer development.
Asada
M
M
Department of Virology, National Children's Medical Research Center.
Mizutani
S
S
D017209:Apoptosis / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics