title: SB-203207 and SB-203208, two novel isoleucyl tRNA synthetase inhibitors from a Streptomyces sp. I. Fermentation, isolation and properties.
abstract: Two novel inhibitors of isoleucyl tRNA synthetase designated SB-203207 and SB-203208 have been detected in the culture of a new Streptomyces species. The fermentation, isolation and some properties of the inhibitors are described.
authors.affiliation: SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Harlow, Essex, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Stefanska
authors.forename: R
authors.initials: R
authors.lastname: Cassels
authors.forename: S J
authors.initials: SJ
authors.lastname: Ready
authors.forename: S R
authors.initials: SR
authors.lastname: Warr
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D007192:Indenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007533:Isoleucine-tRNA Ligase / Q000037:antagonists & inhibitors*; D008826:Microbial Sensitivity Tests; D051381:Rats; D013302:Streptomyces; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D007192:Indenes; C410786:SB 203207; C410787:SB 203208; D013449:Sulfonamides; D007533:Isoleucine-tRNA Ligase