Total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' found in Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor.
The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has been achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated.
Takahata
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H
Toyama Medical and Pharmaceutical University, Sugitani, Japan. takahata@ms.toyama-mpu.ac.jp
Takahashi
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S
Azer
N
N
Eldefrawi
A T
AT
Eldefrawi
M E
ME
D000818:Animals; D001001:Anura; D011485:Protein Binding; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis* / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*; D014101:Torpedo
D011763:Pyrrolizidine Alkaloids; D011978:Receptors, Nicotinic