title: [Analysis of the 32 bp deletion in the CCR5 chemokine receptor gene in people from Moscow, infected with HIV-1].
abstract: Chemokine receptors have recently been shown to mediate HIV-1 entry into cells. The chemokine receptor CCR5 plays a key role in this process. A 32-bp deletion within the coding region of the CCR5 gene generates a truncated nonfunctional receptor. In HIV-1-infected individuals homozygous for this mutation, disease progression is inhibited. We analyzed the frequencies of the deletion in HIV-1-infected seropositive individuals. No significant differences in allelic frequencies of the CCR5 gene between the control and general HIV-1-infected cohorts and within the latter group between the infected individuals and patients with AIDS symptoms were revealed.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.
authors.forename: M I
authors.initials: MI
authors.lastname: Shadrina
authors.forename: V M
authors.initials: VM
authors.lastname: Kapylov
authors.forename: O V
authors.initials: OV
authors.lastname: Miloserdova
authors.forename: P A
authors.initials: PA
authors.lastname: Slominskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Limborskaia
mesh_terms: D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1 / Q000302:isolation & purification; D006720:Homozygote; D006801:Humans; D009031:Moscow / Q000453:epidemiology; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D019713:Receptors, CCR5
vernacular_title: Analiz deletsii 21 pn v gene retseptora khemokinov CCR5 u lits, infitsirovannykh VICh-1, iz g. Moskvy.