title: Biotransformation of lantadene A (22 beta-angeloyloxy-3-oxoolean-12-en-28-oic acid), the pentacyclic triterpenoid, by Alcaligenes faecalis.
abstract: A bacterial strain capable of biotransformation of lantadene A (22 beta-angeloyloxy-3-oxo-olean-12-en-28-oic acid), the pentacyclic hepatotoxin of lantana (Lantana camara var. aculeata) has been isolated from soil using lantadene A as the sole carbon source. The organism is Gram negative, rod shaped, motile, catalase positive and has been identified as Alcaligenes faecalis. The isolate has been found to be specific for lantadene A and did not utilize lantadene B. In studies using sucrose as an additional carbon source, A. faecalis elicited biotransformation of lantadene A to its trans isomer 22 beta-tigloyloxy-3-oxoolean-12-en-28-oic acid, designated as lantadene X and two other minor metabolites which could not be isolated in pure state.
authors.affiliation: Biochemistry Laboratory, Indian Veterinary Research Institute, Palampur, India.
authors.forename: A
authors.initials: A
authors.lastname: Singh
authors.forename: O P
authors.initials: OP
authors.lastname: Sharma
authors.forename: R K
authors.initials: RK
authors.lastname: Dawra
authors.forename: S S
authors.initials: SS
authors.lastname: Kanwar
authors.forename: S B
authors.initials: SB
authors.lastname: Mahato
mesh_terms: D000421:Alcaligenes / Q000254:growth & development / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D012987:Soil; D012988:Soil Microbiology
chemical_list: D012987:Soil; D009828:Oleanolic Acid; C019074:rehmannic acid