title: Mechanical stress regulation and proliferation of rat mandibular condylar chondrocytes in vitro.
abstract: OBJECTIVE
  To study the proliferative changes of cultured rat mandibular condylar chondrocytes effected by mechanical stress.
  
  
  METHODS
  Flow cytometry (FCM) was used to explore the changes of cellular DNA content and cell cycles of passaged condylar chondrocytes.
  
  
  RESULTS
  FCM results indicated that proliferation of cultured rat mandibular condylar chondrocytes decreased with stress duration, with marked differences between the experimental and control groups.
  
  
  CONCLUSIONS
  Within given force duration and force range (0-207 g/an2), proliferation of rat mandibular condylar chondrocytes increased with force magnitude, reaching the maximum 6 hours after application of stress. Cellular proliferation decreased when the chondrocytes were cultured under continuous stress for 24 hours. The mechanism for these proliferation changes requires further study.
authors.affiliation: Department of Orthodontics, College of Stomatology, West China University of Medical Sciences, Chengdu, Sichuan, P. R. China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: S
authors.initials: S
authors.lastname: Luo
mesh_terms: D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D019902:Chondrocytes / Q000502:physiology*; D003799:Dental Stress Analysis; D005434:Flow Cytometry; D008335:Mandibular Condyle / Q000737:chemistry*; D051381:Rats; D013314:Stress, Mechanical