title: Adjunctive thrombus aspiration and mechanical protection from distal embolization in primary percutaneous intervention for acute myocardial infarction.
abstract: Primary percutaneous intervention for acute occlusion of a native coronary artery may be complicated by distal embolization of plaque or thrombotic debris, with infarct extension. We tested the clinical application of a new therapeutic strategy combining maximal antiplatelet therapy, with glycoprotein IIb/IIIa inhibition, and adjunctive mechanical protection from distal embolization and direct aspiration of thrombus with a new balloon and catheter system (PercuSurgetrade mark). Successful aspiration of thrombus could be obtained in 7 out of 8 attempted procedures, with inability to negotiate the angulated take-off of the circumflex coronary artery in one patient. The current mechanical characteristics of the device, primarily developed for use in larger saphenous vein grafts, and certain caveats and limitations are discussed. New dedicated systems should be available in the near future for the native coronary circulation. Excellent immediate angiographic results were obtained in all treated patients, without evidence of loss of distal branches and no intraprocedural complications.
authors.affiliation: Section of Interventional Cardiology, Department of Cardiology "A. De Gasperis," Niguarda Hospital, Milan, Italy. bellig@tiscalinet.it
authors.forename: G
authors.initials: G
authors.lastname: Belli
authors.forename: A
authors.initials: A
authors.lastname: Pezzano
authors.forename: A M
authors.initials: AM
authors.lastname: De Biase
authors.forename: E
authors.initials: E
authors.lastname: Bonacina
authors.forename: P
authors.initials: P
authors.lastname: Silva
authors.forename: P
authors.initials: P
authors.lastname: Salvadè
authors.forename: G
authors.initials: G
authors.lastname: Piccalò
authors.forename: S
authors.initials: S
authors.lastname: Klugmann
mesh_terms: D000077284:Abciximab; D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000473:pathology / Q000601:surgery*; D004617:Embolism / Q000517:prevention & control*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012501:Saphenous Vein; D015607:Stents; D017131:Thrombectomy / Q000295:instrumentation*
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D000077284:Abciximab