Pethidine reverses morphine-induced delirium.
A young patient had unexpected and prolonged postoperative delirium apparently associated with morphine-induced biliary colic. Naloxone had no therapeutic effect, but a small dose of pethidine produced a dramatic return to lucidity. Unrecognized biliary spasm should be considered as a cause of agitation in the recovery room in postoperative patients who have received morphine.
McLoughlin
P D
PD
Department of Anaesthesia, Royal Perth Hospital, Western Australia.
D000293:Adolescent; D017109:Akathisia, Drug-Induced / Q000209:etiology; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D000762:Anesthesia Recovery Period; D001660:Biliary Tract Diseases / Q000139:chemically induced; D003085:Colic / Q000139:chemically induced; D003693:Delirium / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008614:Meperidine / Q000627:therapeutic use*; D009020:Morphine / Q000009:adverse effects*; D009270:Naloxone / Q000627:therapeutic use; D009292:Narcotic Antagonists / Q000627:therapeutic use; D011997:Recovery Room
D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D009270:Naloxone; D009020:Morphine; D008614:Meperidine