Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40.
Given the importance of responding to infections with the right defensive strategy, much interest has focused on cytokine differentiation in CD4+ T cells. However, relatively little is known of the logistics of T-cell help for B cells. Here, Lucy Walker and colleagues propose key roles for CD28 and OX40 in coordinating the selection, expansion and migration of CD4+ T cells to B-cell follicles.
Walker
L S
LS
MRC Centre for Immune Regulation, University of Birmingham, UK. walker@itsa.uesf.edu
Gulbranson-Judge
A
A
Flynn
S
S
Brocker
T
T
Lane
P J
PJ
D000818:Animals; D018106:CD28 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002448:Cell Adhesion / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D018858:Germinal Center / Q000276:immunology; D006801:Humans; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology*
D018106:CD28 Antigens; D053262:Receptors, OX40; D018124:Receptors, Tumor Necrosis Factor; C505716:TNFRSF4 protein, human; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7