title: The application of single cell gel electrophoresis or Comet assay to human monitoring studies.
abstract: OBJECTIVE
  In the search of new human genotoxic biomarkers, the single cell gel electrophoresis assay has been proposed as a sensible alternative.
  
  
  METHODS
  This technique detects principally single strand breaks as well as alkali-labile and repair-retarded sites.
  
  
  RESULTS
  Herein we present our experience using the single cell gel electrophoresis assay in human population studies, both occupationally and environmentally exposed.
  
  
  CONCLUSIONS
  We discuss the assay feasibility as a genotoxic biomarker.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM).
authors.forename: M
authors.initials: M
authors.lastname: Valverde
authors.forename: P
authors.initials: P
authors.lastname: Ostrosky-Wegman
authors.forename: E
authors.initials: E
authors.lastname: Rojas
authors.forename: T
authors.initials: T
authors.lastname: Fortoul
authors.forename: F
authors.initials: F
authors.lastname: Meneses
authors.forename: M
authors.initials: M
authors.lastname: Ramírez
authors.forename: F
authors.initials: F
authors.lastname: Díaz-Barriga
authors.forename: M
authors.initials: M
authors.lastname: Cebrian
mesh_terms: D015415:Biomarkers / Q000032:analysis; D020552:Comet Assay; D004781:Environmental Exposure; D006801:Humans; D008800:Mexico; D008991:Monitoring, Physiologic; D016273:Occupational Exposure; D014505:Urban Population
chemical_list: D015415:Biomarkers