Acute respiratory distress syndrome: low-stretch ventilation improves survival.
In a recent major study, patients with acute respiratory distress syndrome or acute lung injury were randomly assigned to have their respirators set to deliver tidal volumes of either 6 mL/kg or a more-traditional 12 mL/kg. Mortality in the low-tidal-volume group was 31.0%, compared with 39.8% in the traditional-tidal-volume group, a 22% difference (P = .007).
Wiedemann
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Department of Pulmonary and Critical Care Medicine, Cleveland Clinic, USA. wiedemh@ccf.org
Arroliga
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AC
D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy*; D013990:Tidal Volume