Pilot ascending dose tolerance study of parenterally administered 4-(2 hydroxyethyl)-1-piperazine ethane sulfonic acid (TVZ-7) in dogs.
We report a pilot toxicity study in healthy beagle dogs which revealed no significant adverse events for TVZ-7 given at i.v. doses up to 520 mg/kg/day. All treated dogs displayed calm behavior and maintained normal clinical laboratory values throughout the study. Increased bone marrow hypercellularity and extramedullary hematopoiesis was also noted in these dogs. Three other dogs with advanced spontaneously occurring tumors have also been dosed. No serious adverse events were reported in any of the dogs. This pilot study suggests that 4-(2 Hydroxyethyl)-1-piperazine ethane sulfonic acid may be used safely in planned human clinical trials.
Theodore
T R
TR
Integrated Biologics Research Laboratories, Inc., Osterville, Massachusetts 02655, USA.
Van Zandt
R L
RL
Carpenter
R H
RH
D017738:Alkanesulfonic Acids / Q000633:toxicity*; D000818:Animals; D002021:Buffers; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010879:Piperazines / Q000633:toxicity*; D013451:Sulfonic Acids / Q000008:administration & dosage / Q000633:toxicity*
D017738:Alkanesulfonic Acids; D002021:Buffers; D010879:Piperazines; D013451:Sulfonic Acids; C410687:TVZ 7