Lipid trafficking and sorting: how cholesterol is filling gaps.
Recent research has highlighted a role for cholesterol homeostasis in the regulation of trafficking and sorting of sphingolipids. This sorting may dictate the nature of the acyl chain species of phospholipids in the plasma membrane which, in turn, may govern the selective partitioning of these lipids into lateral domains. Recently, several proteins have been identified that play a role in the flow and sorting of all major lipid classes.
Hoekstra
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Department of Physiological Chemistry, University of Groningen, Groningen, 9713 AV, The Netherlands. d.hoekstra@med.rug.nl.
van IJzendoorn
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D000818:Animals; D001692:Biological Transport; D001693:Biological Transport, Active; D002352:Carrier Proteins; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D050356:Lipid Metabolism; D008562:Membrane Glycoproteins; D000077296:Niemann-Pick C1 Protein; D011506:Proteins / Q000378:metabolism; D013107:Sphingolipids / Q000378:metabolism
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; C106881:NPC1 protein, human; D000077296:Niemann-Pick C1 Protein; D011506:Proteins; D013107:Sphingolipids; D002784:Cholesterol