title: Adenoid basal carcinomas of the cervix: a unique morphological evolution with cell cycle correlates.
abstract: Adenoid basal carcinoma (ABC) is a rare cervical carcinoma of postmenopausal women composed of small basal-type (basaloid) cells with focal endocervical ("adenoid") differentiation. ABCs are associated with high-grade squamous intraepithelial lesions (HSIL) and contain integrated human papillomavirus type 16 DNA. However, ABCs have a favorable prognosis and do not metastasize. Five (5) ABCs were analyzed histologically for a marker distinguishing basal/ squamous from columnar (adenoid) differentiation (p63) and cell cycle activity (Ki-67), and compared with 20 cervical (CC) carcinomas. In contrast to other CCs, ABCs contained 4 distinct components, including (1) a classic HSIL; (2) a limited invasive component with squamoid maturation, often with a discrete layer of peripheral basal cells; (3) outgrowth of small basal cells from either HSIL or squamoid areas; (4) focal endocervical (adenoid) differentiation. ABCs showed distinct differences in cell cycle activity relative to CCs. Ki-67 positivity was high in associated HSILs but remained high and concentrated in the suprabasal cells of the invasive squamoid component of ABC. Moreover, proliferative index was variable to sharply reduced in areas of basaloid and adenoid differentiation, in contrast to conventional CCs. ABC is a unique neoplasm, not only by its transition through multiple phenotypes during invasion, but also by a proliferative index that is high in more mature neoplastic cells during the infiltrative process and reduced with progressive basal differentiation. The precise mechanism underlying this unique process of tumor evolution is unclear. However, the postmenopausal status of these patients suggests that host factors related to aging may influence tumor evolution and morphology after HPV 16 infection.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: A
authors.initials: A
authors.lastname: Cviko
authors.forename: B
authors.initials: B
authors.lastname: Briem
authors.forename: S R
authors.initials: SR
authors.lastname: Granter
authors.forename: A P
authors.initials: AP
authors.lastname: Pinto
authors.forename: T Y
authors.initials: TY
authors.lastname: Wang
authors.forename: Y C
authors.initials: YC
authors.lastname: Yang
authors.forename: B F
authors.initials: BF
authors.lastname: Chen
authors.forename: A
authors.initials: A
authors.lastname: Yang
authors.forename: E E
authors.initials: EE
authors.lastname: Sheets
authors.forename: F D
authors.initials: FD
authors.lastname: McKeon
authors.forename: C P
authors.initials: CP
authors.lastname: Crum
mesh_terms: D002280:Basal Cell Carcinoma / Q000473:pathology* / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000821:virology; D002453:Cell Cycle; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D027383:Papillomaviridae / Q000302:isolation & purification; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology
chemical_list: D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53