title: Is trophoblastic thickness at the embryonic implantation site a new sign of negative evolution in first trimester pregnancy?
abstract: In this study a new sign to evaluate the evolution of pregnancy is described: the trophoblastic thickness at the embryonic implantation site. A prospective, observational study of 592 normal pregnancies with no known risk factors was carried out from January 1998 to February 1999. Serial ultrasound scans were performed from week 5 to week 12 of pregnancy. Trophoblastic thickness was measured at the embryonic implantation site to determine the significance of a difference in gestational age in weeks and a trophoblastic thickness of >/=3 mm in predicting poor prognosis in pregnancy outcome. The sensitivity of this sign in the prediction of spontaneous abortion was 82%, the specificity was 93%, the positive predictive value was 63% and the negative predictive value was 97%.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital Universitario Getafe, 28905 Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Bajo
authors.forename: F J
authors.initials: FJ
authors.lastname: Moreno-Calvo
authors.forename: L
authors.initials: L
authors.lastname: Martinez-Cortés
authors.forename: F J
authors.initials: FJ
authors.lastname: Haya
authors.forename: J
authors.initials: J
authors.lastname: Rayward
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D010064:Embryo Implantation; D005314:Embryonic and Fetal Development; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014327:Trophoblasts / Q000000981:diagnostic imaging* / Q000502:physiology*; D014463:Ultrasonography