[p53 transgenic and knockout mice].
Li-Fraumeni syndrome(LFS) and its relation to the p53 gene and p53 gene transgenic and targeting mice are reviewed. LFS is a hereditary cancer-prone syndrome mainly with germ line mutation of p53 gene. p53 deficient mice, especially heterozygous mice, may serve as a model for human LFS, although there are several discrepancies between them. Carcinogenesis experiment using p53 deficient mice may be important to clarify the role of p53 in tumorigenesis in vivo.
Oda
H
H
Department of Pathology, Graduate School of Medicine, University of Tokyo.
D000818:Animals; D004195:Disease Models, Animal; D017353:Gene Deletion; D016158:Genes, p53 / Q000235:genetics* / Q000502:physiology; D018095:Germ-Line Mutation; D006579:Heterozygote; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics*; D008822:Mice, Transgenic / Q000235:genetics*