Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria.
The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.
Takahashi
A
A
Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Japan.
Onodera
K
K
Shinoda
H
H
Mayanagi
H
H
D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced*; D051379:Mice; D009924:Organ Culture Techniques; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity*; D012886:Skull / Q000187:drug effects
C001419:hydroxyphenytoin; D010672:Phenytoin