title: New insights into the thyroid-stimulating hormone receptor. The major antigen of Graves' disease.
abstract: The receptor for thyroid-stimulating hormone is one of the most interesting hormone-binding sites because of its close association with common human diseases, including thyroid nodules and Graves' hyperthyroidism. This article discusses the structure and biosynthetic processing of this elusive glycoprotein, whose paucity and instability have impeded its isolation from natural sources. Topics include cleavage and subunit structure, variant species, and structural modeling, the thyroid-stimulating hormone receptor as the major autoantigen in Graves' disease, and a summary of recent efforts to replicate the symptoms of this uniquely human disease in animal models.
authors.affiliation: Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA. PGraves@smtplink.mssm.edu
authors.forename: P N
authors.initials: PN
authors.lastname: Graves
authors.forename: T F
authors.initials: TF
authors.lastname: Davies
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology*; D004195:Disease Models, Animal; D015870:Gene Expression; D006111:Graves Disease / Q000276:immunology*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011989:Receptors, Thyrotropin / Q000737:chemistry / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D011994:Recombinant Proteins
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D011989:Receptors, Thyrotropin; D011994:Recombinant Proteins