Acute hepatitis in adult Still's disease apparently resulting from oral iron substitution--a case report.
The authors report a case of a young woman with adult-onset Still's disease (AOSD) with massive hyperferritinaemia who developed acute florid hepatitis with intraparenchymatous histiocytic infiltration following oral iron substitution for presumed iron deficiency, which settled on withdrawal of the iron. This suggests that the iron exacerbated the macrophage hyperactivity which is presumed to be present in AOSD. Oral iron substitution in the acute phase of this disease may be inadvisable.
Maclachlan
D
D
University Department of Rheumatology, Basel, Switzerland. maclachlan@t-online.de
Tyndall
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A
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000740:Anemia / Q000150:complications / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000473:pathology; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D016706:Still's Disease, Adult-Onset / Q000150:complications*
D005293:Ferritins; D007501:Iron