The ontogeny of induction of c-fos in the rat SCN by a 5-HT(2A/2C) agonist.
The induction of c-fos in the suprachiasmatic nucleus (SCN) by the 5-HT(2A/2C) agonist, DOI was studied at mid-dark in neonatal rats. The number of cells expressing c-FOS immunoreactivity following DOI was low 3 days after birth, but increased rapidly over the next 3 days. By contrast, light exposure stimulated cells throughout this period. These results are consistent with the arrival of serotonergic afferents at the SCN and their role in the entrainment of rhythms.
Ferguson
S A
SA
Department of Obstetrics and Gynaecology, Medical School, University of Adelaide, Frome Road, Adelaide, South Australia, 5005, Australia.
Kennaway
D J
DJ
D000818:Animals; D002452:Cell Count; D002940:Circadian Rhythm / Q000502:physiology; D003624:Darkness; D005260:Female; D007215:Indophenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D010775:Photic Stimulation; D011247:Pregnancy; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000502:physiology*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013493:Suprachiasmatic Nucleus / Q000166:cytology / Q000254:growth & development / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D017366:Serotonin Receptor Agonists; C113896:dimethoxy-4-indophenyl-2-aminopropane; D007215:Indophenol