Sterol carrier protein-2.
The compartmentalization of cholesterol metabolism implies target-specific cholesterol trafficking between the endoplasmic reticulum, plasma membrane, lysosomes, mitochondria and peroxisomes. One hypothesis has been that sterol carrier protein-2 (SCP2, also known as the non-specific lipid transfer protein) acts in cholesterol transport through the cytoplasm. Recent studies employing gene targeting in mice showed, however, that mice lacking SCP2 and the related putative sterol carrier known as SCPx, develop a defect in peroxisomal beta-oxidation. In addition, diminished peroxisomal alpha-oxidation of phytanic acid (3,7,11, 15-tetramethylhexadecanoic acid) in these null mice was attributed to the absence of SCP2 which has a number of properties supporting a function as carrier for fatty acyl-CoAs rather than for sterols.
Seedorf
U
U
Institute for Arteriosclerosis Research, Institute for Clinical Chemistry and Laboratory Medicine, Interdisciplinary Center for Clinical Research, Westphalian Wilhelms-University, Münster, Germany. seedorfu@uni-muenster.de
Ellinghaus
P
P
Roch Nofer
J
J
D000101:Acetyl-CoA C-Acetyltransferase / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000096:biosynthesis; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism*; D018390:Gene Targeting; D006801:Humans; D010084:Oxidation-Reduction; D010196:Pancreatic Elastase; D020675:Peroxisomes / Q000378:metabolism; D010831:Phytanic Acid / Q000378:metabolism; D010940:Plant Proteins; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D001647:Bile Acids and Salts; D002352:Carrier Proteins; D010940:Plant Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C072087:sterol carrier proteins; D010831:Phytanic Acid; D000101:Acetyl-CoA C-Acetyltransferase; D010196:Pancreatic Elastase; C017130:cholesterol-binding protein