Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives.
Cephalosporins with 3-pyazolylpyridinium at C-3 position, which is supposed to exhibit synergic activity of ceftazidime and cefoselis, were synthesized and their antibacterial activity against gram-positive and gram-negative was inspected.
Chang
K Y
KY
Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.
Kim
S H
SH
Nam
G
G
Seo
J H
JH
Kim
J H
JH
Ha
D C
DC
D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011726:Pyridinium Compounds / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D011726:Pyridinium Compounds; D000644:Quaternary Ammonium Compounds