[Teratogenicity study of sodium chlorite in rats by oral administration].
The teratogenicity of sodium chlorite (NaClO2) was assessed in Wistar rats (Crj: Wistar). Sodium chlorite dissolved in distilled water was given to pregnant Wistar rats by gavage once a day from day 6 through 15 of pregnancy at doses of 0, 25, 50 and 100 mg/kg/day. The pregnant rats were sacrificed on day 20 of pregnancy, and their fetuses were examined for malformations. Sodium chlorite caused decreased food consumption, anemia, sedation, hematuria, and death in the pregnant rats at 100 mg/kg, but no fetal effects, such as malformations or growth retardation, were observed even at 100 mg/kg. It was concluded that sodium chlorite has no teratogenicity in rats when administered orally. The no-observed-adverse-effect level was 50 mg/kg/day for pregnant rats and 100 mg/kg/day or more for rat fetuses.
Sakemi
K
K
sakemi@nihs.go.jp
Usami
M
M
Kurebayashi
H
H
Ohno
Y
Y
D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000740:Anemia / Q000139:chemically induced; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D006417:Hematuria / Q000139:chemically induced; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D002712:Chlorides; C001599:chlorite