[The effect of yeast glycans in experimental LPS-induced endotoxicosis].
The immunomodulating action of yeast glycans obtained from Rhodotorula rubra (rhonasan) and Sporobolomyces albo-rubescens (heteroglycan Sp-50) was studied under the conditions of experimental endotoxicosis in mice, induced by the injection of the sublethal dose of Escherichia coli lipopolysaccharide (LPS). In endotoxicosis glycans produced a protective effect, depending on the time of injection. The study demonstrated that after the injection of glycans the survival rate of the animals increased and the LPS-inhibited function of peritoneal macrophages and B lymphocytes was completely or partially restored.
Gurina
S V
SV
Chemico-Pharmaceutical Academy, St. Petersburg, Russia.
Fedorova
L G
LG
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D004353:Drug Evaluation, Preclinical; D019446:Endotoxemia / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D004926:Escherichia coli; D007111:Immunity, Cellular / Q000187:drug effects; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000633:toxicity*; D051379:Mice; D003904:Mitosporic Fungi; D011134:Polysaccharides / Q000627:therapeutic use*; D012248:Rhodotorula; D013997:Time Factors
D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D011134:Polysaccharides
Vliianie glikanov drozhzheĭ pri éksperimental'nom éndotoksikozom, vyzvannom LPS.