Antifungal substances against pathogenic fungi, talaroconvolutins, from talaromyces convolutus.
The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans. In the course of a search for the active compounds, four new tetramic acid derivatives, talaroconvolutins A (1), B (2), C (3), and D (4), were isolated along with ZG-1494alpha (5), and mitorubrin derivatives. The structures of talaroconvolutins A-D (1-4) were established on the basis of spectroscopic and chemical investigations and chemical correlations. The antifungal activity of the talaroconvolutins against the pathogenic fungi Aspergillus fumigates, Aspergillus niger, C. albicans, and Cryptococcus neoformans was determined.
Suzuki
S
S
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Hosoe
T
T
Nozawa
K
K
Kawai
K i
Ki
Yaguchi
T
T
Udagawa
S
S
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology*; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology*
D000935:Antifungal Agents; D009281:Naphthalenes; D011753:Pyrones