title: In vitro activity of eight fluoroquinolones against multiresistant Stenotrophomonas maltophilia.
abstract: We studied the activity of eight fluoroquinolones (norfloxacin, ciprofloxacin, grepafloxacin, trovafloxacin, gatifloxacin, clinafloxacin, PD-117596 and PD-138312) against 58 multiresistant Stenotrophomonas maltophilia clinical strains. Norfloxacin was the least active drug (MIC(90) = 128 mg/l). Grepafloxacin, trovafloxacin and gatifloxacin activity was moderately higher (MIC(90) = 8 mg/l) than ciprofloxacin (MIC(90) = 16 mg/l). The best activity was shown by clinafloxacin and PD-138312 (MIC(90) = 4 mg/l). The most resistant strains showed similar MICs against all the fluoroquinolones tested. The highest increase of activity of newer fluoroquinolones was observed against the most sensitive strains.
authors.affiliation: Departamento de Microbiología, Hospital Universitario de Salamanca, Paseo de San Vicente s/n, 37007 Salamanca.
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Hernández
authors.forename: M A
authors.initials: MA
authors.lastname: Manzanares
authors.forename: M N
authors.initials: MN
authors.lastname: Gutiérrez Zufiaurre
authors.forename: S
authors.initials: S
authors.lastname: Muñoz Criado
authors.forename: J L
authors.initials: JL
authors.lastname: Muñoz Bellido
authors.forename: J A
authors.initials: JA
authors.lastname: García-Rodríguez
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D024841:Fluoroquinolones; D006801:Humans; D020615:Stenotrophomonas maltophilia / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones