[Xenografts and the probability of viral zoonotic risk: reflections based on the sanitary control of a pig population free from specific pathogenic organisms and risk analysis].
An analysis of the risk factors involved has been made and a classical approach has been adopted, consisting of at least six stages. In the context of risk assessment and identification of potential danger, the pathogenic agents in the pig have been identified and those which are potentially pathogenic to man have been indicated. The risk of spreading, and exposure to certain pathogenic agents (SEPA) varies depending on the nature of the donor organs. The risk factors should be managed by a quality-control approach, which at the sanitary level should consist of controlling all production levels in the pig population, from rearing to slaughtering, and the subsequent removal of vital organs and tissue for xenotransplantation or xenografts. The personnel involved should also undergo rigorous medical examination.
Vannier
P
P
Afssa, Ploufragan, France.
Carriolet
R
R
D000822:Animal Husbandry / Q000592:standards; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D006801:Humans; D006920:Hygiene; D009181:Mycoses / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D010273:Parasitic Diseases, Animal / Q000517:prevention & control / Q000635:transmission; D011786:Quality Control; D018570:Risk Assessment; D012307:Risk Factors; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology / Q000517:prevention & control* / Q000635:transmission; D014183:Transplantation, Heterologous / Q000009:adverse effects*; D014777:Virus Diseases / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D015047:Zoonoses / Q000635:transmission
X¿enogreffes et probabilit¿e du risque viral zoonotique: r¿eflexions ¿a partir de la ma¿itrise sanitaire des porcs exempts d'organismes pathog¿enes sp¿ecifi¿es et analyse du risque.