Control of cell behaviour by signalling through Eph receptors and ephrins.
Eph receptor tyrosine kinases and ephrins mediate contact-dependent cell interactions that regulate the repulsion and adhesion mechanisms involved in the guidance and assembly of cells. Recent work has revealed a role of overlapping Eph receptor and ephrin expression in modulating neuronal growth cone repulsion, and has shown that bidirectional activation restricts intermingling and communication between cell populations. In addition, progress has been made in understanding how Eph receptors and ephrins control cell adhesion.
Mellitzer
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Division of Developmental Neurobiology, National Institute for Medical Research, Mill Hill, NW7 1AA, UK.
Xu
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Wilkinson
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DG
D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D036382:Ephrin-A1; D036387:Ephrin-B1; D008565:Membrane Proteins / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011506:Proteins / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D036224:Receptor, EphB4; D036081:Receptors, Eph Family; D015398:Signal Transduction / Q000502:physiology*
D036382:Ephrin-A1; D036387:Ephrin-B1; D008565:Membrane Proteins; D011506:Proteins; D020794:Receptor Protein-Tyrosine Kinases; D036224:Receptor, EphB4; D036081:Receptors, Eph Family