Detection of neuroendocrine feature about salivary adenoid cystic carcinoma.
OBJECTIVE
To study the possibility of neuroendocrine feature of salivary adenoid cystic carcinoma (SACC).


METHODS
Immunohistochemical staining was operated in SACC with S-100 protein, neurospecific enolase (NSE), chromogranin A, and synaptophysin, which are specific and correlative with neuroendocrine cells and neoplasias.


RESULTS
The positive expression of S-100, NSE, chromogranin, and synaptophysin were 42, 32, 8, and 7, respectively, in 50 cases of SACC.


CONCLUSIONS
Neuroendocrine feature in some SACC cells is possibly indicated.
Sun
C
C
Department of Oral and Maxillofacial Surgery, First Affiliated Hospital, China Medical University (CMU), P. R. China. stfbdc@pub.sy.ln,en
Zhong
M
M
Wang
Z
Z
Wang
Y
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D003528:Carcinoma, Adenoid Cystic / Q000737:chemistry / Q000473:pathology*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis*; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D009418:S100 Proteins; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase