title: A common T/C polymorphism in the promoter region of the beta T-cell receptor gene.
abstract: Polymorphisms in the T-cell receptor genes can provide important information for the study of the immune response system, particularly for autoimmune diseases. This report characterizes a common T to C polymorphism in the promoter of the beta 2 constant chain of the T-cell receptor, which abolishes a recognition site for BglII restriction endonuclease.
authors.affiliation: Department of Pathology, University of Milan, Ospedale S. Paolo via A. di Rudini 8, Milano, 20142, Italy. pasquale@mailserver.unimi.it
authors.forename: P
authors.initials: P
authors.lastname: Tripputi
authors.forename: D
authors.initials: D
authors.lastname: Graziani
authors.forename: R M
authors.initials: RM
authors.lastname: Alfano
authors.forename: B
authors.initials: B
authors.lastname: Cassani
authors.forename: G
authors.initials: G
authors.lastname: Coggi
mesh_terms: D000328:Adult; D000483:Alleles; D001426:Bacterial Proteins; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D019674:Genes, T-Cell Receptor beta / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011401:Promoter Regions, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; C024404:BglII endonuclease; D015252:Deoxyribonucleases, Type II Site-Specific