Comparison of vancomycin pharmacodynamics (1 g every 12 or 24 h) against methicillin-resistant staphylococci.
This study compared the duration of serum bactericidal activity for vancomycin, 1 g every 12 or 24 h at steady state, against methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci (MR-CNS). All four test isolates were susceptible to vancomycin with minimal inhibitory concentration (MIC) values of either 2 or 4 mg/l. Serum bactericidal titres (SBTs) were run in duplicate and serum bactericidal activity (SBA) was defined as the time points at which all subject SBTs were greater than or equal to 1:2. For the every 12-h regimen, SBA was 10-12 h. With the every 24-h regimen, the duration of SBA was 10-16 h for MRSA and 8-10 h for MR-CNS. The pharmacodynamic data suggest that for those with good renal function a Q12h dosing interval is most appropriate for MR-CNS or staphylococcal isolates with MICs of 4.
Lacy
M K
MK
Department of Pharmacy Practice, School of Pharmacy, The University of Kansas Medical Center, 3901 Rainbow Boulevard, 66160-7231, Kansas City, KS 66160-7231, USA. mlacy@kumc.edu
Tessier
P R
PR
Nicolau
D P
DP
Nightingale
C H
CH
Quintiliani
R
R
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics*; D001770:Blood Bactericidal Activity; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D011446:Prospective Studies; D013211:Staphylococcus aureus / Q000187:drug effects*; D014640:Vancomycin / Q000009:adverse effects / Q000493:pharmacokinetics*
D000900:Anti-Bacterial Agents; D014640:Vancomycin