title: Dose-volume analysis of different stereotactic radiotherapy mono-isocentric techniques.
abstract: Several stereotactic irradiation techniques, using Linacs with the patient in lying and sitting position and a Gamma Knife Unit, were compared with regard to mono-isocentric three-dimensional dose distributions. Three types of target volumes, a sphere and two ellipsoids, were used for the comparisons. All three targets were centered on a real head, reconstructed from transversal CT scans. The ARTEMIS 3D Treatment Planning System, developed by the Tenon Hospital, Paris, was used for the dosimetry and the dose-volume histogram (DVH) calculation. For the comparative study, several quantitative parameters were used, derived from the dose-volume histogram calculation. Differential DVHs were plotted for each target volume and beam arrangement. Irradiation techniques were compared by deriving quantitative parameters from the DVHs such as mean and integral dose delivered to the target and normal tissue irradiated, as well as by the relative volume of the examined areas. All techniques used in this study produced very similar dose distributions. The small differences confirm the capability of the studied techniques to produce the same irradiation effects. By changing from the spherical target shape to a more elliptical shape, more of the normal tissue was irradiated with higher doses. For elliptical cases we therefore identified a need for more conformal stereotactic planning.
authors.affiliation: University of Patras Medical School, Medical Physics Department, Rio Patras, Greece. ktheodor@med.upatras.gr
authors.forename: K
authors.initials: K
authors.lastname: Theodorou
authors.forename: K
authors.initials: K
authors.lastname: Platoni
authors.forename: D
authors.initials: D
authors.lastname: Lefkopoulos
authors.forename: C
authors.initials: C
authors.lastname: Kappas
authors.forename: M
authors.initials: M
authors.lastname: Schlienger
authors.forename: O
authors.initials: O
authors.lastname: Dahl
mesh_terms: D001932:Brain Neoplasms / Q000601:surgery; D019583:Dose Fractionation, Radiation; D006801:Humans; D010347:Patient Care Planning; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed