The problems of using the transmission/disequilibrium test to infer tight linkage.
Family-based association methods such as the transmission/disequilibrium test (TDT) have become very popular during the past few years, often being preferred to case-control studies because family-based approaches avoid the difficulties of ascertainment of appropriate populations of cases and controls for case-control studies. Significant TDT results indicate both linkage and allelic association. However, significant TDT results are often interpreted as implying tight linkage of marker and disease locus, and we shall argue here that, in general, this interpretation is not justified.
Whittaker
J C
JC
Department of Applied Statistics, University of Reading, 6FN, United Kingdom. j.c.whittaker@reading.ac.uk
Denham
M C
MC
Morris
A P
AP
D000483:Alleles; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data; D005787:Gene Frequency / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000453:epidemiology / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D009679:Nuclear Family; D015995:Prevalence; D015203:Reproducibility of Results