The metabolic hypothesis revisited.
High levels of CO are used to mimic the stimulatory response of the CSN initiated by hypoxia. Using light of different wavelengths we show that the stimulatory effects of high CO can be pinpointed to the cytochrome c oxidase in the mitochondrial respiratory chain. This supports the metabolic theory of oxygen sensing in the mitochondria.
Rozanov
C
C
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia 19104-6085, USA.
Roy
A
A
Mokashi
A
A
Osanai
S
S
Daudu
P
P
Storey
B
B
Lahiri
S
S
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism; D002344:Carotid Body / Q000378:metabolism*; D002415:Cats; D002628:Chemoreceptor Cells / Q000378:metabolism*; D003576:Electron Transport Complex IV / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism; D066298:In Vitro Techniques; D008928:Mitochondria / Q000378:metabolism; D008959:Models, Neurological; D010100:Oxygen / Q000378:metabolism*; D010477:Perfusion
D002248:Carbon Monoxide; D003576:Electron Transport Complex IV; D010100:Oxygen; D002118:Calcium