Insulin resistance and hypertension. Patients in double jeopardy for cardiovascular disease.
Essential hypertension is prevalent among older individuals, and approximately 50% of persons with hypertension can be considered to have insulin resistance and hyperinsulinemia. It appears likely that insulin resistance and hyperinsulinemia predispose to, rather than result from, hypertension. Insulin resistance is associated with abnormalities in lipoprotein metabolism, hypercoagulability, and endothelial function, which probably account in part for the increased cardiovascular risk among hypertensive patients. To identify this subset of patients, all hypertensive patients should be screened for diabetes and lipid abnormalities. The presence of impaired glucose tolerance, diabetes, or hypertriglyceridemia and low HDL suggest the presence of insulin resistance. Insulin resistant patients, in particular, will benefit from exercise and weight loss.
McLaughlin
T
T
Department of Medicine, Stanford University School of Medicine, CA, USA.
Reaven
G
G
D000368:Aged; D002318:Cardiovascular Diseases / Q000503:physiopathology* / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000503:physiopathology* / Q000628:therapy; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D011379:Prognosis; D012307:Risk Factors
D008055:Lipids