Understanding the insertion of transporters and other membrane proteins.
Recent studies show that transporters integrate into the lipid bilayer using topogenic sequences present throughout the entire polypeptide chain. These topogenic sequences can act in unpredictable ways with new translocation/stop transfer activities. In addition, a new membrane-insertion pathway has been identified in bacteria with homologs in mitochondria and chloroplasts.
Dalbey
R E
RE
Department of Chemistry, Ohio State University, Columbus, 43210, USA. dalbey@chemistry.ohio-state.edu.
Chen
M
M
Jiang
F
F
Samuelson
J C
JC
D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*
D002352:Carrier Proteins; D008565:Membrane Proteins