Antioxidative effects of Choi-oki-to and its ability to inhibit the progression of atheroma in KHC rabbits.
Agents which inhibit the oxidative modification of low density lipoprotein (LDL) have been thought to be helpful in preventing the formation of atherosclerotic lesions; the so called "oxidation hypothesis". To test this hypothesis, we examined the antioxidative activities of 127 Kampo medicines in vitro and their inhibitory effects on the development of atheromatous plaque formation in KHC rabbits, a model of spontaneous familial hypercholesterolemia. Some of the 127 Kampo medicines showed scavenging or antioxidative effects equal to or stronger than those of probucol in vitro. Choi joki to, which had the strongest antioxidative effects on LDL in vitro, was chosen for a study in vivo. After 24 weeks, 1 g/kg of Choi joki to successfully inhibited the progression of atherosclerotic lesions in KHC rabbits (P < 0.01). Further investigations regarding the antioxidative effects of Kampo medicines are expected.
Iizuka
A
A
Kampo & Pharmacognosy Laboratory, Tsumura & Co., Ibaraki, Japan.
Iijima
O T
OT
Kondo
K
K
Matsumoto
A
A
Itakura
H
H
Yoshie
F
F
Komatsu
Y
Y
Takeda
H
H
Matsumiya
T
T
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000378:metabolism*; D020835:Medicine, Kampo; D011817:Rabbits
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D008077:Lipoproteins, LDL