title: Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.
abstract: Two analogues of bovine beta-casomorphin-7 and beta-casomorphin-5 containing a beta-homo phenylalanine in substitution of the phenylalanine in position 3 were synthesised and tested for their mu-opioid receptor affinity. The modification enhanced the mu receptor affinity 5-fold in the case of modified beta-CM-7 and 2-fold for modified beta-CM-5 when compared to the natural peptides.
authors.affiliation: Dipartinento di Scienza degli Alimenti, Università di Napoli Federico II, Portici, Italy. luilongo@unina.it
authors.forename: L
authors.initials: L
authors.lastname: Longobardo
authors.forename: D
authors.initials: D
authors.lastname: Melck
authors.forename: R
authors.initials: R
authors.lastname: Siciliano
authors.forename: A
authors.initials: A
authors.lastname: Santini
authors.forename: V
authors.initials: V
authors.lastname: Di Marzo
authors.forename: G
authors.initials: G
authors.lastname: Cammarota
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004723:Endorphins / Q000737:chemistry / Q000378:metabolism*; D010649:Phenylalanine / Q000737:chemistry*; D011485:Protein Binding; D051381:Rats; D017450:Receptors, Opioid, mu / Q000378:metabolism*
chemical_list: D004723:Endorphins; D017450:Receptors, Opioid, mu; D010649:Phenylalanine; C021968:beta-casomorphins