title: Treatment of perioral rhytides: a comparison of dermabrasion and superpulsed carbon dioxide laser.
abstract: OBJECTIVE
  To directly compare the cosmetic outcome and adverse effects of dermabrasion and superpulsed carbon dioxide laser for the treatment of perioral rhytides.
  
  
  METHODS
  Subjects were randomly assigned to receive treatment with carbon dioxide laser resurfacing to one side of the perioral area and dermabrasion to the other side in a prospective, comparative clinical study. The duration of follow-up by blinded observers was 4 months.
  
  
  METHODS
  University hospital-based dermatologic surgery clinic.
  
  
  METHODS
  Fifteen healthy fair-skinned volunteers with moderate to severe perioral rhytides and no history of prior cosmetic surgical procedures to the same anatomic area.
  
  
  METHODS
  One half of the perioral area was treated with the LX-20SP Novapulse carbon dioxide laser (Luxar Corp, Bothell, Wash), and the other half was treated with dermabrasion using either a hand engine-driven diamond fraise or a medium-grade drywall sanding screen (3M Corp, St Paul, Minn).
  
  
  METHODS
  Improvement in rhytides, patients' subjective reports of postoperative pain, time to reepithelialization, degree of postoperative crusting, and duration of postoperative erythema were observed for both methods. Standardized scoring systems were used to quantify outcome measures. Paired t tests were used for statistical comparisons of the 2 resurfacing methods.
  
  
  RESULTS
  The difference in rhytide scores for the 2 methods was not statistically significant (P= .35) at 4 months. Less postoperative crusting and more rapid reepithelialization were noted with the dermabrasion-treated skin. Postoperative erythema was of longer duration on laser-treated skin. Patients reported less pain with dermabrasion treatment. Subtle differences that were difficult to quantify were also noted between the methods.
  
  
  CONCLUSIONS
  Both dermabrasion and carbon dioxide laser resurfacing are effective in the treatment of perioral rhytides. Both methods have unique advantages and disadvantages.
authors.affiliation: Department of Surgery, Boston University School of Medicine and Boston Medical Center, Massachusetts, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Holmkvist
authors.forename: G S
authors.initials: GS
authors.lastname: Rogers
mesh_terms: D000328:Adult; D000368:Aged; D003869:Dermabrasion / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008046:Lip / Q000601:surgery*; D008875:Middle Aged; D011446:Prospective Studies; D015595:Skin Aging; D016896:Treatment Outcome