title: [Insulin resistance. Frequently administration errors are the source].
abstract: The term insulin resistance includes both physiological and pathological metabolic changes. Physiological insulin resistance, for example, is to be found in puberty or in advanced old age; additionally, it may be caused by endocrinological diseases. A pathologically elevated insulin requirement is to be found in the insulin resistance syndrome, type A (genetic) or type B (insulin receptor antibodies). In recent times, however, a massively elevated insulin requirement has been observed in increasing numbers of type 2 diabetics, in whom a subcutaneous insulin resistance is suspected--a condition that can be verified by various tests. The treatment of choice for breaking down this resistance is the intravenous administration of sufficiently high-dosed insulin that is as closely matched to the sugar profile as possible. In many cases the return to subcutaneous insulin--which again must be adequately high dosed--becomes possible during the further course of the disease. In addition, a case of insulin resistance caused by patient manipulation is described.
authors.affiliation: III. Medizinische Abteilung für Endokrinologie, Stoffwechsel und Angiologie, Krankenhaus München-Bogenhausen. mail@rendschmidt.de
authors.forename: T
authors.initials: T
authors.lastname: Rendschmidt
authors.forename: H J
authors.initials: HJ
authors.lastname: Lüddeke
authors.forename: R
authors.initials: R
authors.lastname: Renner
authors.forename: K D
authors.initials: KD
authors.lastname: Hepp
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects; D007333:Insulin Resistance; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
vernacular_title: Insulinresistenz. Häufig stecken Applikationsfehler dahinter.