title: Transoral laser surgery for early glottic carcinoma.
abstract: This prospective study evaluates the oncological results of transoral laser surgery (TLS) for glottic carcinoma categorized Tis, T1 and T2 in a large, unselected group of 285 consecutive patients from a university-based referral center that uses transoral laser surgery as the standard approach to these tumors. Patients were treated between 1 January 1987 and 31 December 1996. Thirty-three patients had Tis disease, 174 T1 tumors and 113 T2. Main outcome measures were local control with initial therapy, ultimate local control, regional control, organ preservation, overall survival and cause-specific survival. The 5-year uncorrected actuarial survival for all 285 patients was 71.1%, and cause-specific actuarial survival was 98.7%. Local control with initial treatment was 85.9%, ultimate local control with salvage for local treatment failures 98.5%, and regional control 98.4%. In all, 94.3% had their larynges preserved after 5 years. Although favorable oncological results for early laryngeal carcinoma treated with laser surgery are supported this study, no definitive recommendations can be given for the best single treatment. Partial laryngectomies lead to the highest local control rates reported so far, radiotherapy is believed to preserve voice best and laser surgery is associated with time- and cost-effectiveness, low morbidity, fair local control rates and excellent re-treatment options in case of local failure. All specialists dealing with the treatment of early glottic carcinoma should be able to offer these different treatment modalities to their patients and to deal specifically with each patient's individual needs and preferences.
authors.affiliation: Department of Otorhinolaryngology, University of Cologne, Germany. hans.eckel@uni-koeln.de
authors.forename: H E
authors.initials: HE
authors.lastname: Eckel
authors.forename: W
authors.initials: W
authors.lastname: Thumfart
authors.forename: M
authors.initials: M
authors.lastname: Jungehülsing
authors.forename: C
authors.initials: C
authors.lastname: Sittel
authors.forename: E
authors.initials: E
authors.lastname: Stennert
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D005500:Follow-Up Studies; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D007828:Laryngoscopy / Q000379:methods; D053685:Laser Therapy / Q000379:methods; D009055:Mouth; D009367:Neoplasm Staging; D011446:Prospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome