Assessment of antimycobacterial activity of a series of mainly marine derived natural products.
A series of mainly marine derived natural products were tested for their activities against Mycobacterium tuberculosis and M. avium. Of the thirty-nine compounds tested fifteen demonstrated minimum inhibition concentrations (MICs) of 32 micrograms/ml or less, and eleven had MICs of 16 micrograms/ml or less. The most active compound found in this study was the sponge derived metabolite axisonitrile-3 (MIC 2 micrograms/ml).
König
G M
GM
Institute for Pharmaceutical Biology, University of Bonn, Germany. g.koenig@uni-bonn.de
Wright
A D
AD
Franzblau
S G
SG
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D006801:Humans; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*
D000900:Anti-Bacterial Agents