title: Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.
abstract: Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.
authors.affiliation: Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Pearson
authors.forename: M
authors.initials: M
authors.lastname: Feldman
authors.forename: B H
authors.initials: BH
authors.lastname: Iglewski
authors.forename: A
authors.initials: A
authors.lastname: Prince
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology; D004195:Disease Models, Animal; D005798:Genes, Bacterial; D008025:Ligases; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D018410:Pneumonia, Bacterial / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D011552:Pseudomonas Infections / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; C081237:LasI protein, Pseudomonas aeruginosa; D014157:Transcription Factors; D008025:Ligases; C096955:RHLI protein, Pseudomonas aeruginosa