title: 9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis.
abstract: 9-Benzylpurines with a variety of substituents in the 2-, 6- and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans-styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.
authors.affiliation: Department of Chemistry, University of Oslo, Norway.
authors.forename: A K
authors.initials: AK
authors.lastname: Bakkestuen
authors.forename: L L
authors.initials: LL
authors.lastname: Gundersen
authors.forename: G
authors.initials: G
authors.lastname: Langli
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: J M
authors.initials: JM
authors.lastname: Nolsøe
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000995:Antitubercular Agents; D011687:Purines