Sclerosing epithelioid fibrosarcoma: a cytogenetic, immunohistochemical, and ultrastructural study of an unusual histological variant.
A case of sclerosing epithelioid fibrosarcoma was studied. The tumor cells expressed vimentin, focally epithelial membrane antigen and CD34, contained cisternae of rough endoplasmic reticulum, large Golgi apparatus, many pinocytotic vesicles, and were devoid of basal lamina. Their composite karyotype was 45,Y,t(X;6)(q13;q15), t(6;13)(p11.2;q13),-22¿2/46,Y,t(X;6)(q13;q15),add(13)(p12), add(22)(q13)¿3/44 approximately 46,der(X)t(X;6)(q13;q21),-Y, t(13;14)(q10;q10),-22,add(22)(q13)¿7/46,XY¿8.
Donner
L R
LR
Department of Pathology, Scott & White Clinic and Memorial Hospital, Scott, Sherwood and Brindley Foundation, Texas A&M University System Health Science Center, College of Medicine, Temple, TX 76508, USA.
Clawson
K
K
Dobin
S M
SM
D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002999:Clone Cells; D005354:Fibrosarcoma / Q000737:chemistry / Q000145:classification / Q000276:immunology / Q000473:pathology*; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D019394:Ki-67 Antigen / Q000032:analysis; D007866:Leg; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D015534:Trans-Activators / Q000235:genetics
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D015534:Trans-Activators