Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia.
Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical circuits that adaptively regulate sympathetic and cardiovascular activities.
Sica
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Department of Medicine, Pulmonary and Critical Care Division, Long Island Jewish, Medical Center, Long Island Campus of the Albert Einstein College of Medicine, New Hyde Park, NY 11040, USA. asica@snet.net
Greenberg
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Scharf
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SM
Ruggiero
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DA
D000222:Adaptation, Physiological / Q000502:physiology; D000818:Animals; D002908:Chronic Disease; D015870:Gene Expression / Q000502:physiology; D017781:Genes, Immediate-Early / Q000502:physiology*; D006179:Gyrus Cinguli / Q000503:physiopathology; D002534:Hypoxia, Brain / Q000503:physiopathology*; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016760:Proto-Oncogene Proteins c-fos