[Lichen sclerosus - present-day hormonal therapy].
Several treatment modalities of lichen sclerosus have been described. Topical testosterone (2%) has been the therapy of choice with improvement of symptoms in 67-100% of the patients. Newer placebo-controlled studies report success rates for testosterone of 20% which is not much higher than for placebo (10%). Treatment with the very potent steroid-like clobetasol 0.05% has been shown to be much more effective with success rates of up to 75%, while corticosteroid-related side effects like skin atrophy have not been a major problem.
Küng
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Klinik für Endokrinologie, Departement für Frauenheilkunde, Universitätsspital Zürich, Schweiz. fkueng@dplanet.ch
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D002990:Clobetasol / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D018459:Lichen Sclerosus et Atrophicus / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D013739:Testosterone / Q000008:administration & dosage / Q000627:therapeutic use; D014845:Vulvar Diseases / Q000175:diagnosis / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006728:Hormones; D013739:Testosterone; D011374:Progesterone; D002990:Clobetasol
Lichen sclerosus - hormonelle Therapie heute.