title: Osteoporosis: an unusual presentation of childhood Crohn's disease.
abstract: Osteoporosis is known to be associated with Crohn's disease. We report a 12-yr-old boy without a history of steroid use, in whom severe osteoporosis and multiple collapsed vertebrae were the presenting manifestations of Crohn's disease. After treatment of the Crohn's disease, he resumed normal growth and progressed through puberty. Concomitantly, he demonstrated a substantial recovery of vertebral bone mineral density and structure. Possible pathophysiological mechanisms underlying the osteoporosis and the subsequent improvement in bone density are discussed.
authors.affiliation: Division of Pediatric Endocrinology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
authors.forename: M
authors.initials: M
authors.lastname: Thearle
authors.forename: M
authors.initials: M
authors.lastname: Horlick
authors.forename: J P
authors.initials: JP
authors.lastname: Bilezikian
authors.forename: J
authors.initials: J
authors.lastname: Levy
authors.forename: J M
authors.initials: JM
authors.lastname: Gertner
authors.forename: L S
authors.initials: LS
authors.lastname: Levine
authors.forename: M
authors.initials: M
authors.lastname: Harbison
authors.forename: W
authors.initials: W
authors.lastname: Berdon
authors.forename: S E
authors.initials: SE
authors.lastname: Oberfield
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003424:Crohn Disease / Q000175:diagnosis* / Q000178:diet therapy* / Q000188:drug therapy; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007585:Jews; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D000077268:Pamidronate; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging
chemical_list: D000893:Anti-Inflammatory Agents; D004164:Diphosphonates; D000469:Alkaline Phosphatase; D000077268:Pamidronate; D008775:Methylprednisolone