Time-dependent changes of tissue erythorbic acid concentrations in guinea pigs.
The concentrations of erythorbic acid(ErA) and L-ascorbic acid(AsA) in the tissues of guinea pigs orally administered AsA or ErA were measured over the passage of time using high-performance liquid chromatography. Guinea pigs were each administered 5 mg AsA or 100 mg ErA, and killed at a specified time thereafter. The AsA concentrations in the tissues of AsA-administered guinea pigs and the ErA concentrations in the tissues of ErA-administered guinea pigs increased for 3 h after the respective administrations and decreased thereafter in both groups. The AsA concentration in the tissues of AsA-administered guinea pigs tended to be similar to the sum of AsA and ErA concentrations in the ErA-administered guinea pigs within 3 h after administration.
Suzuki
E
E
Department of Human Biological Studies, Ochanomizu University, Tokyo, Japan.
Kurata
T
T
Miyake
N
N
Nishikawa
Y
Y
Arakawa
N
N
D000311:Adrenal Glands / Q000737:chemistry; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006168:Guinea Pigs; D007668:Kidney / Q000737:chemistry; D008099:Liver / Q000737:chemistry; D013154:Spleen / Q000737:chemistry; D013997:Time Factors
C005056:isoascorbic acid; D001205:Ascorbic Acid