title: Maintenance of intestinal epithelium structural integrity and mucosal leukocytes during chemotherapy by oral administration of muramyl tripeptide phosphatidylethanolamine.
abstract: The systemic administration of doxorubicin (DXR) decreases the number of epithelial cells and leukocytes in the small intestine of mice. Oral administration of muramyl tripeptide phosphatidylethanolamine (MTP-PE) prevented both disruption of intestinal architecture, and a decrease in the number of macrophages, and it induced the expression of IL-6, G-CSF, GM-CSF, and TNF-alpha in the intestinal tissue. The data suggest that the oral administration of MTP-PE can prevent chemotherapy-induced toxicity to the intestinal mucosa and hence infections due to translocation of aerobic bacteria from the intestine to the blood.
authors.affiliation: Department of Cell Biology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Killion
authors.forename: C D
authors.initials: CD
authors.lastname: Bucana
authors.forename: R
authors.initials: R
authors.lastname: Radinsky
authors.forename: Z
authors.initials: Z
authors.lastname: Dong
authors.forename: T
authors.initials: T
authors.lastname: O'Reilly
authors.forename: G
authors.initials: G
authors.lastname: Bilbe
authors.forename: L
authors.initials: L
authors.lastname: Tarcsay
authors.forename: I J
authors.initials: IJ
authors.lastname: Fidler
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D016207:Cytokines / Q000235:genetics; D004317:Doxorubicin / Q000633:toxicity; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007962:Leukocytes / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010714:Phosphatidylethanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D010714:Phosphatidylethanolamines; D012333:RNA, Messenger; C037144:mifamurtide; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D004317:Doxorubicin