title: (A)symptomatic necrotizing arteritis of the female genital tract.
abstract: OBJECTIVE
  The vasculitides represent a heterogenous set of disorders that differ in prognosis and response to therapy. Beside systemic vasculitides, the development of localized forms of arteritis is well known though uncommon and the etiopathogenesis is not yet definitely clear.
  
  
  METHODS
  Patients with necrotizing arteritis of the female genital tract proven by histology are studied in a retrospective analysis.
  
  
  RESULTS
  Three cases of necrotizing arteritis with histological features of panarteritis nodosa apparently confined to the female genital tract are presented. None of these patients had prior history of systemic vasculitis. The acute necrotizing vasculitis was confined only to the uterine cervix in two patients and involved all the internal genital organs in the third patient. The patients have been observed for up to 4 years without any therapy for these lesions and without any manifestation of systemic vasculitic progression.
  
  
  CONCLUSIONS
  It is to speculate that focal arteritis of the female genital tract is a benign form of panarteritis nodosa or moreover a totally different entity with identical morphogenesis but possibly different pathogenesis. Furthermore it seems to be important to be aware of the specificity of focal arteritis in female genital tract as distinct from the generalized form to prevent unnecessary surgical or chemotherapeutical therapy for this lesion. The benign entity of local arteritis in the female genital tract is discussed in contrast to the severe prognosis of systemic panarteritis nodosa.
authors.affiliation: Department of Obstetrics and Gynecology of the Johannes-Gutenberg University of Mainz, Mainz, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Pilch
authors.forename: U
authors.initials: U
authors.lastname: Schäffer
authors.forename: S
authors.initials: S
authors.lastname: Günzel
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: B
authors.initials: B
authors.lastname: Tanner
authors.forename: P
authors.initials: P
authors.lastname: Brockerhoff
authors.forename: P G
authors.initials: PG
authors.lastname: Knapstein
mesh_terms: D000368:Aged; D002584:Cervix Uteri / Q000098:blood supply; D005187:Fallopian Tubes / Q000098:blood supply; D005260:Female; D005836:Genitalia, Female / Q000098:blood supply*; D006801:Humans; D008595:Menorrhagia; D008875:Middle Aged; D009215:Myometrium / Q000098:blood supply; D010053:Ovary / Q000098:blood supply; D010488:Polyarteritis Nodosa / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D014592:Uterine Hemorrhage