Expression of interferon alpha/beta receptor in human hepatocellular carcinoma.
Interferon-alpha (IFNalpha) plays a crucial role in the antiproliferation and immunoregulatory activity through the specific cell surface receptor, interferon-alpha/beta receptor (IFNalpha/betaR). We examined the immunohistochemical expression of IFNalpha/betaR in 91 hepatocellular carcinoma (HCC), HCV-related chronic hepatitis (n=38) and cirrhosis (n=53), dysplastic nodules (n=5), and normal liver (n=9). The level of IFNalpha/betaR increased in chronic hepatitis and cirrhosis compared with normal liver. All the dysplastic nodules showed moderate or high expression. In HCCs, 26% (24/91) of patients showed high IFNalpha/betaR expression while the remaining 38% (35/91) showed moderate, and 35% (32/91) no or faint expression. Clinicopathological survey demonstrated a significant correlation between IFNalpha/betaR expression and differentiation of carcinoma (P=0.0008) although there was no correlation between IFNalpha/betaR expression in HCC and survival or disease-free survival. Thus, IFNalpha/betaR was expressed not only in chronic hepatitis or liver cirrhosis but in HCC and its expression was significantly correlated with tissue differentiation of carcinoma.
Kondo
M
M
Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Japan.
Nagano
H
H
Sakon
M
M
Yamamoto
H
H
Morimoto
O
O
Arai
I
I
Miyamoto
A
A
Eguchi
H
H
Dono
K
K
Nakamori
S
S
Umeshita
K
K
Wakasa
K
K
Ohmoto
Y
Y
Monden
M
M
D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D005260:Female; D019698:Hepatitis C, Chronic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D008103:Liver Cirrhosis / Q000276:immunology / Q000473:pathology; D008113:Liver Neoplasms / Q000737:chemistry / Q000276:immunology* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011230:Precancerous Conditions / Q000276:immunology* / Q000473:pathology; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000032:analysis*
D008565:Membrane Proteins; D017471:Receptors, Interferon; D053633:Receptor, Interferon alpha-beta