title: Lethal photosensitization, autogenous bone, and e-PTFE membrane for the treatment of peri-implantitis: preliminary results.
abstract: This clinical study reports on the results of a new method in the treatment of peri-implantitis. The surfaces of 24 plasma flame-sprayed cylindric implants in 17 patients who were diagnosed with peri-implantitis were decontaminated with a combination of toluidine blue (100 micrograms/mL) and laser irradiation at a wavelength of 906 nm. Bone defects were filled with autogenous bone using e-PTFE membranes for retention of the grafting material. Premature membrane exposure occurred in all patients after an average of 3 weeks (+/- 10 days), which required immediate removal of the exposed membrane in 1 patient. Since the soft tissue showed minimal signs of inflammation, the membranes were left in situ for another 6 weeks in all other patients. The mean radiographic peri-implant bone gain was 2 mm +/- 1.90 mm after 9.5 months (maxilla 2.5 mm +/- 2.38 mm; mandible 1.9 mm +/- 1.87 mm). Two implants around which the initial bone defect had already reached the basket had to be removed after 10 months and 35 months, respectively, despite radiographic evidence of improvement of the peri-implant defect. The longer the membrane stayed in situ, the more bone was gained, as long as the membrane was covered by soft tissue (P = .01). However, the longer an exposed membrane was left in place, the smaller the resultant bone gain (P = .0001). Therefore, despite the absence of clinical signs of inflammation, exposed membranes should be removed immediately. The short-term results of this study corroborate the efficacy of the applied treatment method in prolonging the service time of dental implants involved with peri-implantitis.
authors.affiliation: Department of Oral Surgery, Dental School, University of Vienna, Austria. robert.haas@univie.ac.at
authors.forename: R
authors.initials: R
authors.lastname: Haas
authors.forename: M
authors.initials: M
authors.lastname: Baron
authors.forename: O
authors.initials: O
authors.lastname: Dörtbudak
authors.forename: G
authors.initials: G
authors.lastname: Watzek
mesh_terms: D016301:Alveolar Bone Loss / Q000628:therapy; D001421:Bacteria, Anaerobic / Q000187:drug effects / Q000528:radiation effects; D001861:Bone Regeneration; D004396:Coloring Agents / Q000494:pharmacology; D003666:Decontamination / Q000379:methods; D003758:Dental Implantation, Endosseous / Q000009:adverse effects / Q000379:methods; D015921:Dental Implants / Q000009:adverse effects* / Q000382:microbiology*; D004866:Equipment Contamination / Q000517:prevention & control; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008567:Membranes, Artificial; D010518:Periodontitis / Q000209:etiology / Q000628:therapy*; D017319:Photosensitizing Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene; D018709:Statistics, Nonparametric; D014048:Tolonium Chloride / Q000494:pharmacology; D016896:Treatment Outcome
chemical_list: D004396:Coloring Agents; D015921:Dental Implants; D008567:Membranes, Artificial; D017319:Photosensitizing Agents; D014048:Tolonium Chloride; D011138:Polytetrafluoroethylene