Outcomes and complications of fetal tissue transplantation in Parkinson's disease.
This study was undertaken to investigate the outcomes, complication rates and risk factors of stereotactic intrastriatal neurotransplantation for Parkinson's disease (PD). Bilateral stereotactic neurotransplantation was performed (as previously described) in 60 patients with idiopathic PD. Clinical outcome was evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS). The incidence of complication was evaluated by retrospective analysis of the clinical outcomes of the transplanted patients. Patients demonstrated significant improvement in UPDRS scores 12 months after transplantation. Nine patients experienced adverse effects after neurotransplantation, 3 requiring surgical intervention. Patients showed a significant overall improvement and no greater incidence of risk than that of other intracranial procedures.
Jacques
D B
DB
Good Samaritan Hospital, Neurosciences Institute, Los Angeles, California 90017, USA.
Kopyov
O V
OV
Eagle
K S
KS
Carter
T
T
Lieberman
A
A
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology; D001927:Brain Diseases / Q000453:epidemiology / Q000209:etiology; D016380:Brain Tissue Transplantation / Q000009:adverse effects; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology; D003131:Combined Modality Therapy; D003560:Cysts / Q000453:epidemiology / Q000209:etiology; D005260:Female; D016332:Fetal Tissue Transplantation / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D012640:Seizures / Q000453:epidemiology / Q000209:etiology; D013238:Stereotaxic Techniques; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology; D016896:Treatment Outcome
D000978:Antiparkinson Agents