title: Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease.
abstract: Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal vulnerability in Alzheimer disease, a chronic neurodegeneration. Such ectopic localization of various cyclins, cyclin-dependent kinases, and cyclin inhibitors in neurons can be seen as an attempt to re-enter the cell cycle. Given that primary neurons are terminally differentiated, any attempted re-entry into the cell division cycle in this postmitotic environment will be dysregulated. Since successful dysregulation of the cell cycle is also the hallmark of a neoplasm, early cell-cycle pathophysiology in Alzheimer disease may recruit oncogenic signal transduction mechanisms and, hence, can be viewed as an abortive neoplastic transformation.
authors.affiliation: Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: A K
authors.initials: AK
authors.lastname: Raina
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: C A
authors.initials: CA
authors.lastname: Rottkamp
authors.forename: M
authors.initials: M
authors.lastname: Monteiro
authors.forename: A
authors.initials: A
authors.lastname: Takeda
authors.forename: M A
authors.initials: MA
authors.lastname: Smith
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D016213:Cyclins / Q000502:physiology*; D006801:Humans; D009857:Oncogenes / Q000502:physiology*
chemical_list: D016213:Cyclins