Serial analysis of MLL-AF4 chimeric message through successful bone marrow transplantation in a patient with t(4;11)-positive infant-ALL.
A 28-month-old girl with acute lymphoblastic leukemia (ALL) showing a t(4;11)(q21;q23) karyotype successfully underwent allogeneic bone marrow transplantation (BMT) at relapse. The chimeric MLL-AF4 message on her bone marrow (BM) specimens, examined by reverse transcriptase-polymerase chain reaction, was detectable at diagnosis, relapse, and just before BMT but became undetectable following BMT. She has since maintained complete remission. This observation suggests that detection of the chimeric message in BM may be useful to predict clinical outcome in patients with t(4;11) ALL.
Tabata
Y
Y
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan. tabata@ped.kpu-m.ac.jp
Hibi
S
S
Maruyama-Tabata
H
H
Tsunamoto
K
K
Todo
S
S
Sawada
T
T
Okamura
T
T
Kawa-Ha
K
K
Imashuku
S
S
D014408:Biomarkers, Tumor / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000502:physiology; D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005260:Female; D006801:Humans; D007223:Infant; D051788:Myeloid-Lymphoid Leukemia Protein; D009363:Neoplasm Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000628:therapy*; D011993:Recombinant Fusion Proteins / Q000235:genetics*; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; C113855:MLL-AF4 fusion protein, human; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D011993:Recombinant Fusion Proteins; D051788:Myeloid-Lymphoid Leukemia Protein