title: Surgical management of intractable epilepsy in children with hemophilia.
abstract: Intracranial hemorrhage occurs in 2-8% of patients with hemophilia and can result in neurologic sequelae including seizure disorders. There is a paucity of data concerning the surgical treatment of epilepsy in children with hemophilia. We review our experience with 2 children who developed medically refractory seizure disorders. Both children underwent hemispherotomy, at 18 months (case 1) and 13 years of age (case 2), respectively. Perioperative management included continuous factor replacement. Both children tolerated surgical intervention without complications or increased neurologic deficit. Case 2 showed a 90% reduction in seizure frequency, and case 1 is seizure free. Surgical management of intractable epilepsy in children with hemophilia is safe and effective.
authors.affiliation: Departments of Surgery, Children's Medical Center, Medical College of Georgia, Augusta 30912, USA. dyeh@mail.mcg.edu
authors.forename: D J
authors.initials: DJ
authors.lastname: Yeh
authors.forename: M
authors.initials: M
authors.lastname: Lee
authors.forename: Y D
authors.initials: YD
authors.lastname: Park
authors.forename: J R
authors.initials: JR
authors.lastname: Smith
authors.forename: A L
authors.initials: AL
authors.lastname: Lightsey
mesh_terms: D001921:Brain / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000150:complications / Q000209:etiology; D002648:Child; D004828:Epilepsies, Partial / Q000209:etiology* / Q000601:surgery*; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology* / Q000601:surgery*; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D012086:Reoperation; D016896:Treatment Outcome