Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs.
We investigated the brains of non-demented individuals with mitral valve prolapse (MVP) and found evidence of Alzheimer-like lesions. This neuropathology consisted of premature presence of beta-amyloid-containing senile plaques (SP) without increased prevalence of neurofibrillary tangles. Low levels of SP occurred in 20 to 45- year-old subjects with MVP, and much greater densities were observed in subjects between 45 and 62 years of age. We also investigated the brains of adolescent Yorkshire pigs undergoing cardiopulmonary bypass surgery and likewise found evidence of Alzheimer-like neuropathology. This took the form of intraneuronal accumulation of beta-amyloid immunoreactivity and increasing numbers of Alz-50 immunoreactive neurons with reduced recovery of cardiac efficiency after the surgery. Based on prevailing concepts in Alzheimer's disease, it is feasible to hypothesize that cognitive dysfunction occurring after cardiopulmonary bypass surgery with coronary artery grafting or valve repair/replacement is a functional sequela of AD-like neuropathology. This postulate is based on the premise that an individual seeking such surgery would have pre-existing, elevated AD-like neuropathology to start with. It is further coupled with the probability that these forms of cardiovascular surgery exacerbate the extent and progression of AD-like neuropathology.
Sparks
D L
DL
Haldeman Laboratory for Alzheimer's Disease Research, Sun Health Research Institute, 10510 W. Santa Fe Drive, Sun City, AZ 85351, USA. lsparksd@mail.sunhealth.org
Gross
D R
DR
Hunsaker
J C
JC
D000328:Adult; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000941:Antigens / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry / Q000502:physiology; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003072:Cognition Disorders / Q000473:pathology; D003327:Coronary Disease / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D008945:Mitral Valve Prolapse / Q000473:pathology*; D009206:Myocardium / Q000473:pathology; D016874:Neurofibrillary Tangles / Q000473:pathology; D058225:Plaque, Amyloid / Q000473:pathology; D013552:Swine
C056167:Alzheimer's disease antigen; D016229:Amyloid beta-Peptides; D000941:Antigens