title: Clinicopathologic findings and results of surgical treatment in cardiac adenocarcinoma.
abstract: OBJECTIVE
  There is a great deal of controversy regarding the definition, classification, and staging of cardiac adenocarcinoma (CA). Recently, a shift from distal to proximal lesions has been documented in gastric cancer. We have stratified our cases of gastric cancer as CA, distal gastric cancer (DGC), and stump cancer (SC).
  
  
  METHODS
  Between 1986 and 1998, 450 patients with gastric cancer were operated on at our institute. The resectability rate was 81.6%. Of 367 patients, 48 were CA, 298 DGC, and 21 SC. These 3 groups were compared in terms of clinicopathologic factors and survival rates.
  
  
  RESULTS
  CA was significantly higher in male patients and showed a prevalence of the Lauren intestinal type. Regarding staging parameters, CA showed a higher rate of T3 tumors and of resection line involvement. Five-year survival rates were 23. 2% for CA, 45.0% for DGC, and 17.4% for SC.
  
  
  CONCLUSIONS
  A possible cause of the poor outcome of CA is presentation at a more advanced stage. CA was similar to SC as far as epidemiology, pathologic factors, and survival rates.
authors.affiliation: Institute of General Surgery, University of Florence, Italy. clin_chir_dc@unifi.it
authors.forename: L
authors.initials: L
authors.lastname: Bruno
authors.forename: G
authors.initials: G
authors.lastname: Nesi
authors.forename: F
authors.initials: F
authors.lastname: Montinaro
authors.forename: G
authors.initials: G
authors.lastname: Carassale
authors.forename: R
authors.initials: R
authors.lastname: Lassig
authors.forename: V
authors.initials: V
authors.lastname: Boddi
authors.forename: P
authors.initials: P
authors.lastname: Bechi
authors.forename: C
authors.initials: C
authors.lastname: Cortesini
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002299:Cardia / Q000601:surgery; D005260:Female; D005743:Gastrectomy / Q000401:mortality; D018530:Gastric Stump / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D016896:Treatment Outcome