title: Radiotherapy in the management of cervical cancer in elderly patients.
abstract: OBJECTIVE
  To report treatment results and complications experienced by elderly patients treated with curatively intended radiotherapy for cancer of the uterine cervix.
  
  
  METHODS
  One hundred and fourteen elderly patients (median 75.5 years, range 70.0-85.9) consecutively referred for curative radiotherapy in the period 1987-1996 were prospectively followed with regard to tumour control and complications. The importance of age, stage (FIGO), tumour size, histology, tumour fixation, haemoglobin, concurrent disease, performance status (WHO) and type of radiotherapy were assessed using univariate and multivariate analyses.
  
  
  RESULTS
  Treatment was completed as planned in 68%, delayed in 29% and stopped prematurely in 3%. The frequency of grade 3 late complications was 11% and the actuarial probability at 5 years was 20%. Overall 5-year survival according to FIGO was 61% (I), 34% (II) and 25% (III). Cox multivariate analysis identified tumour size as independent prognostic factor for tumour control, disease-free survival and overall survival. FIGO stage was predictive for late grade 2 complications. We were unable to identify significant factors with respect to grade 3 complications. Age was not a significant parameter for any of the investigated endpoints.
  
  
  CONCLUSIONS
  Elderly patients in good performance status with advanced cancer of the uterine may tolerate radical radiotherapy with acceptable morbidity and reasonable survival. Radiotherapy may also be a good alternative in early stage disease for surgically unfit elderly patients.
authors.affiliation: Department of Oncology, Building 5, Aarhus University Hospital, DK-8000, Aarhus, Denmark.
authors.forename: J C
authors.initials: JC
authors.lastname: Lindegaard
authors.forename: I R
authors.initials: IR
authors.lastname: Thranov
authors.forename: S A
authors.initials: SA
authors.lastname: Engelholm
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D005260:Female; D006801:Humans; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011882:Radiotherapy, High-Energy; D016019:Survival Analysis; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*