Phosphorylated PmrA interacts with the promoter region of ugd in Salmonella enterica serovar typhimurium.
The Salmonella PmrA-PmrB system controls the expression of genes necessary for polymyxin B resistance. Four loci were previously identified as part of the regulon, and interaction of PmrA with the promoter region of three of them was observed. Here we characterized the interaction of PmrA with the promoter region of ugd, previously suggested to be regulated indirectly by PmrA. Our results indicate that PmrA controls the expression of ugd by interacting with a specific sequence in the promoter region of this gene.
Aguirre
A
A
Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
Lejona
S
S
Véscovi
E G
EG
Soncini
F C
FC
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001483:Base Sequence; D001665:Binding Sites; D004269:DNA, Bacterial; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D019779:Salmonella enterica / Q000201:enzymology* / Q000235:genetics; D014533:Uridine Diphosphate Glucose Dehydrogenase / Q000235:genetics*
D001426:Bacterial Proteins; D004269:DNA, Bacterial; C081902:pmrA protein, Bacteria; D014533:Uridine Diphosphate Glucose Dehydrogenase