MHC-I expression in HTLV-1-positive and -negative cells.
The expression level of major histocompatibility class I (MHC-I) and the extent of down-regulation of MHC-I after an anti-MHC-I antibody treatment in numerous human T-cell leukemia virus type 1 (HTLV-1)-positive and -negative lymphocytic cell lines were examined. While there was no clear correlation between the expression level of MHC-I and the presence of HTLV-1 genome, a relatively low level of MHC-I down-regulation was generally induced in HTLV-1-positive cells by the antibody. The results may suggest the potential involvement of MHC-I in HTLV-1 leukemogenesis.
Yoshida
A
A
Department of Virology, The University of Tokushima School of Medicine, Tokushima 770-8503, Japan.
Miyaura
M
M
Sakurai
A
A
Fukumori
T
T
Fujita
M
M
Akari
H
H
Adachi
A
A
D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015153:Blotting, Western; D002460:Cell Line; D015536:Down-Regulation; D005805:Genes, MHC Class I; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism* / Q000821:virology
D000911:Antibodies, Monoclonal; D015395:Histocompatibility Antigens Class I