[Parvovirus B19 infection mimicking drug-induced hypersensitivity syndrome].
BACKGROUND
Clinical manifestations of primary parvovirus B19 infection vary greatly. Epidermal megalerythema is the most common feature. We report a particular form resembling a drug-induced hypersensitivity reaction.


METHODS
A 19-year-old man had a scarlatiniform eruption associated with multiple node enlargement, elevated liver enzymes and a abnormal white cell count with mononucleosis and lymphopenia, similar to that observed in hypersensitivity reactions. Seroconversion and positive PCR search for viral DNA established the diagnosis of primary parvovirus B19 infection. The spontaneous course was favorable with no recurrence at one month.


CONCLUSIONS
The clinical features and laboratory findings in this case of parvovirus B19 infection closely resembled drug-induced hypersensitivity syndrome. The role of viral agents in the development of hypersensitivity reactions have been suggested. It is important to look for viral infections in clinical presentations mimicking drug-induced hypersensitivity.
Regnier
S
S
Service de Dermatologie, Hôpital Bichat, 46, rue Henri-Huchard, 75877 Paris Cedex 18.
Descamps
V
V
Boui
M
M
Lebrun-Vignes
B
B
Descamps
D
D
Grossin
M
M
Belaïch
S
S
Crickx
B
B
D000328:Adult; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005500:Follow-Up Studies; D006801:Humans; D007244:Infectious Mononucleosis / Q000821:virology; D007958:Leukocyte Count; D008099:Liver / Q000201:enzymology; D008199:Lymphadenitis / Q000821:virology; D008231:Lymphopenia / Q000821:virology; D008297:Male; D010322:Parvoviridae Infections / Q000175:diagnosis*; D016732:Parvovirus B19, Human
Primo-infection à Parvovirus B 19 mimant un syndrome d'hypersensibilité médicamenteuse.