title: Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the republic of maldives cribrochalina species.
abstract: Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10(-5) to 10(-7) % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) (1)H and (13)C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 2(2) and the newly isolated cribrostatins 3-5 displayed antibacterial and/or antifungal activities.
authors.affiliation: Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287-2404, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: J C
authors.initials: JC
authors.lastname: Knight
authors.forename: J C
authors.initials: JC
authors.lastname: Collins
authors.forename: D L
authors.initials: DL
authors.lastname: Herald
authors.forename: R K
authors.initials: RK
authors.lastname: Pettit
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
authors.forename: V G
authors.initials: VG
authors.lastname: Young
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D018360:Crystallography, X-Ray; D006801:Humans; D007195:Indian Ocean Islands; D007546:Isoquinolines / Q000737:chemistry* / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011161:Porifera / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D007546:Isoquinolines; C412686:cribrostatin 3; C412688:cribrostatin 4; C412687:cribrostatin 5; C018106:mimosamycin