title: Exposure to solvents in a synthetic leather manufacturing plant.
abstract: The objective of this study was to evaluate the exposure of synthetic leather workers to dimethylformamide (DMF), epichlorohydrin (ECH) and toluene, in a manufacturing plant. The correlation between biological and environmental monitoring for DMF was also investigated. Environmental monitoring of the three solvents included personal and area sampling based on time of day (morning and afternoon). Urine samples were taken at the end of the shift and urinary N-methylformamide (NMF) was then used to biologically monitor DMF levels. Results for solvent concentrations based on air sampling were considerably higher in area than in personal sampling. Of 41 area samples, 15 (36.6%) and five (12.2%) exceeded permissible exposure levels for DMF and ECH, respectively, compared with 22 (28.6%) and three (3.9%) based on 77 personal samples. Overall, urinary NMF concentrations were lower than the Biological Exposure Index (BEI) suggested by the American Conference of Governmental Industrial Hygienists (ACGIH). A significant correlation (r = 0.32; P < 0.05) was found between environmental and biological monitoring. Even though urinary NMF concentration was within permissible levels for Taiwan, the authors recommend that immediate measures be taken to decrease DMF and ECH concentrations in synthetic leather manufacturing plants.
authors.affiliation: Institute of Environmental Health, China Medical College, Taichung, Taiwan. wukuo@mail.cmc.edu.tw
authors.forename: H W
authors.initials: HW
authors.lastname: Kuo
authors.forename: Y S
authors.initials: YS
authors.lastname: Huang
authors.forename: J C
authors.initials: JC
authors.lastname: Lo
authors.forename: T J
authors.initials: TJ
authors.lastname: Cheng
authors.forename: M J
authors.initials: MJ
authors.lastname: Wu
mesh_terms: D000328:Adult; D004126:Dimethylformamide / Q000032:analysis*; D004811:Epichlorohydrin / Q000032:analysis*; D006801:Humans; D007221:Industry; D008297:Male; D008420:Manufactured Materials; D016273:Occupational Exposure / Q000032:analysis*; D012016:Reference Values; D012997:Solvents / Q000032:analysis*; D014050:Toluene / Q000032:analysis*; D016482:Urinalysis
chemical_list: D012997:Solvents; D004811:Epichlorohydrin; D014050:Toluene; D004126:Dimethylformamide