Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains.
Definition of cellular responses to cytokines often involves cross-communication through their respective receptors. Here, signaling by interferon-gamma (IFN-gamma) is shown to depend on the IFN-alpha/beta receptor components. Although these IFNs transmit signals through distinct receptor complexes, the IFN-alpha/beta receptor component, IFNAR1, facilitates efficient assembly of IFN-gamma-activated transcription factors. This cross talk is contingent on a constitutive subthreshold IFN-alpha/beta signaling and the association between the two nonligand-binding receptor components, IFNAR1 and IFNGR2, in the caveolar membrane domains. This aspect of signaling cross talk by IFNs may apply to other cytokines.
Takaoka
A
A
Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Mitani
Y
Y
Suemori
H
H
Sato
M
M
Yokochi
T
T
Noguchi
S
S
Tanaka
N
N
Taniguchi
T
T
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004268:DNA-Binding Proteins / Q000378:metabolism; D019281:Dimerization; D004686:Encephalomyocarditis virus / Q000187:drug effects / Q000502:physiology; D007370:Interferon Type I / Q000378:metabolism*; D016898:Interferon-alpha / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D016899:Interferon-beta / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology; D007371:Interferon-gamma / Q000378:metabolism* / Q000494:pharmacology; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D008565:Membrane Proteins; D051379:Mice; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D020239:Receptor Cross-Talk; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon / Q000235:genetics / Q000378:metabolism*; D011994:Recombinant Proteins; D050794:STAT1 Transcription Factor; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism; D000096743:Interferon gamma Receptor
D004268:DNA-Binding Proteins; D007370:Interferon Type I; D016898:Interferon-alpha; D016899:Interferon-beta; D007371:Interferon-gamma; D053613:Janus Kinase 1; D053614:Janus Kinase 2; D008565:Membrane Proteins; D019000:Phosphotyrosine; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D053633:Receptor, Interferon alpha-beta; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D050794:STAT1 Transcription Factor; D015534:Trans-Activators; D000096743:Interferon gamma Receptor; C508032:Ifnar1 protein, mouse; C494080:Stat1 protein, mouse; C507905:Jak1 protein, mouse; C507926:Jak2 protein, mouse