Hypervitaminosis A and bone.
Animal, human, and in vitro data all indicate that excess vitamin A stimulates bone resorption and inhibits bone formation. This combination would be expected to produce bone loss and to contribute to osteoporosis development and may occur with relatively low vitamin A intake. It is possible that unappreciated hypervitaminosis A contributes to osteoporosis pathogenesis.
Binkley
N
N
Institute on Aging, University of Wisconsin, Madison 53706, USA.
Krueger
D
D
D000818:Animals; D001846:Bone Development / Q000187:drug effects; D001862:Bone Resorption / Q000209:etiology; D006801:Humans; D006986:Hypervitaminosis A / Q000150:complications*; D010024:Osteoporosis / Q000209:etiology*; D012176:Retinoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use
D012176:Retinoids