[The effect of different infectious agents on the intensification of hematopoiesis during immunosuppression].
The action of Staphylococcus aureus, Escherichia coli and Herpes simplex virus on the hemopoiesis of mice with cytostatic myelosuppression was studied. The study revealed that the infection of the animals simultaneously with the action of cyclophosphamide considerably activated the processes leading to the restoration of hemopoiesis due to an increase in the mitotic activity of hemopoietic cells, the accelerated differentiation of hemopoietic precursor cells which could survive the cytostatic action and an increase in the functional activity of the hemopoiesis-producing microenvironment.
Karpova
M R
MR
Siberian State Medical University, Research Institute of Pharmacology, Tomsk, Russia.
Zvereva
I F
IF
Novitskiĭ
V V
VV
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology; D001772:Blood Cell Count / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000097:blood / Q000382:microbiology; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D006561:Herpes Simplex / Q000097:blood / Q000821:virology; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D007108:Immune Tolerance / Q000187:drug effects / Q000502:physiology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D013203:Staphylococcal Infections / Q000097:blood / Q000382:microbiology; D013211:Staphylococcus aureus / Q000472:pathogenicity*; D013997:Time Factors
D018906:Antineoplastic Agents, Alkylating; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide
Vliianie razlichnykh infektsionnykh agentov na usilenie krovetvoreniia v usloviiakh immunosupressii.