[Role of CDC25 phosphatases in the control of proliferation].
Progression in cell cycle is controlled by CDKs (cyclin dependent kinases) and their cyclins regulatory subunits. In mammalian cells, three dual specificity phosphatases called CDC25 activate CDKs/cyclin complexes. The activity of CDC25 is regulated by phosphorylation and dephosphorylation events. CDC25 phosphatases also participate in cell cycle checkpoints activated in response to DNA damage. Two members of this family, CDC25 A and CDC25 B, have oncogenic properties, and their overexpression has been detected in various types of tumors.
Davezac
N
N
Laboratoire de biologie cellulaire et moléculaire du contrôle de la prolifération, université Paul-Sabatier, CNRS UMR 5088, Toulouse, France.
Ducommun
B
B
Baldin
V
V
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division / Q000502:physiology*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004249:DNA Damage; D004789:Enzyme Activation; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D010766:Phosphorylation; D020687:cdc25 Phosphatases / Q000235:genetics / Q000502:physiology*
D018844:Cyclin-Dependent Kinases; D020687:cdc25 Phosphatases
Rôle des phosphatases CDC25 dans le contrôle de la prolifération.