Widespread countervailing genomic responses induced by chemotherapy or radiation as a cause of therapeutic failure.
If chemotherapy or ionizing radiation induce widespread genomic responses tending to circumvent or antagonize their ability to kill malignant cells, an additional cause for therapeutic failure would be suggested. There is evidence that some agents evoke extensive countervailing genomic activity, the nature and extent of which can be assessed with the use of 'gene chips'.
Anderson
K M
KM
Departments of Medicine, Rush Medical College, Chicago, IL, USA.
Alrefai
W A
WA
Anderson
C A
CA
Bonomi
P
P
Harris
J E
JE
D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D016678:Genome; D006801:Humans; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents