[Variants in the immune response to revaccination with diphtheria anatoxin in adults].
The immunological effectiveness of the revaccination (made in two injections) of 488 adults aged 18-67 years with diphtheria-tetanus toxoid is discussed; the parallel study of the results of this revaccination was carried out in the diphtheria toxin neutralization test on Vero cells and in the passive hemagglutination (PHA) test. The specific features of the dynamics of the increase of diphtheria antitoxic antibodies, depending on the initial immunity level, the age and the sex of revaccinated persons, were determined. Among persons with the low level of circulating antibodies before revaccination four variants of immune response to the injection of diphtheria toxoid were registered: variant 1--rapid reaction like in secondary immune response (53.6%); variant 2--delayed but effective reaction like in primary immune response (27.3%); variant 3--slow weak response (6.5%); and variant 4--the absence of effective immune response to immunization made in 2-3 injections (12.6%). The immunological and neutralizing properties of diphtheria antitoxic antibodies in the process of immunization made in 2 injections were evaluated. Persons with abnormal immune response (variants 3 and 4) produced defective antibodies, displaying immunological activity in the PHA test, but in most cases unable to neutralize diphtheria toxin in vitro when tested on Vero cells.
Demikhovskaia
E V
EV
Gromashevsky Research Institute of Epidemiology and Infectious Diseases, Kiev, Ukraine.
Chudnaia
L M
LM
Hardy
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology; D000907:Antibodies, Bacterial / Q000097:blood*; D003353:Corynebacterium diphtheriae / Q000276:immunology*; D004168:Diphtheria Toxoid / Q000276:immunology*; D022422:Diphtheria-Tetanus Vaccine; D006801:Humans; D007117:Immunization, Secondary / Q000706:statistics & numerical data; D008875:Middle Aged; D012727:Sex Characteristics; D013745:Tetanus Toxoid / Q000276:immunology; D013997:Time Factors; D017778:Vaccines, Combined / Q000276:immunology
D000907:Antibodies, Bacterial; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D013745:Tetanus Toxoid; D017778:Vaccines, Combined
Varianty immunnogo otveta na revaktsinatsiiu difteriĭnym anatoksinom u vzroslykh.