title: [Epidemiological risk factors for non-traumatic osteonecrosis].
abstract: Certain fractures and/or dislocations of the femoral head are known to cause arterial injury and result in post-traumatic osteonecrosis. However, the more complex etiology of non-traumatic osteonecrosis is multifactorial and includes chemotherapy, radiotherapy, thermal injuries, and especially coagulopathies, which are now commonly observed in these patients. Intravascular coagulation with fibrin thrombosis begins in the capillaries and sinusoids of the intraosseous microcirculation, and residual venous thrombosis is more likely to occur if there is coexistent hypofibrinolysis. Coagulopathies are intermediary events, which are always activated by some underlying etiologic risk factor(s). Conditions capable of triggering intravascular coagulation include familial thrombophilia (resistance to activated protein C, decreased protein C, protein S, or antithrombin III, and hyperhomocystinemia), hyperlipemia and embolic lipid (alcoholism and hypercortisonism), hypersensitivity reactions (allograft organ rejection, immune complexes, and antiphospholipid antibodies), bacterial endotoxic (Shwartzman) reactions and various viral infections, proteolytic enzymes (pancreatitis), tissue factor release (inflammatory bowel disease, malignancies, neurotrauma, and pregnancy), and other thrombophilic and hypofibrinolytic disorders. Currently known risk factors for non-traumatic osteonecrosis of the femoral head are described briefly in this review article.
authors.affiliation: Diagnostic Osteonecrosis Center and Research Foundation, Kelseyville, CA 95451, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Jones
mesh_terms: D000328:Adult; D015984:Causality; D005260:Female; D005271:Femur Head Necrosis / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D011247:Pregnancy; D012307:Risk Factors
vernacular_title: Epidemiologische Risikofaktoren für die nichttraumatische Osteonekrose.